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Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Carriage of Clostridium difficile by Wild Urban Norway Rats (Rattus norvegicus) and Black Rats (Rattus rattus)  

Science Journals Connector (OSTI)

...Carriage of Clostridium difficile by Wild Urban Norway Rats (Rattus norvegicus) and Black Rats (Rattus rattus) Chelsea G. Himsworth a b David...objective of this study was to determine whether urban rats (Rattus spp.) from Vancouver, Canada, carry...

Chelsea G. Himsworth; David M. Patrick; Sunny Mak; Claire M. Jardine; Patrick Tang; J. Scott Weese

2013-12-06T23:59:59.000Z

2

ECOLOGY OF NORWAY RATS (RATTUS NORVEGICUS) IN RELATION TO CONSERVATION AND MANAGEMENT OF SEABIRDS ON KISKA ISLAND,  

E-Print Network [OSTI]

ECOLOGY OF NORWAY RATS (RATTUS NORVEGICUS) IN RELATION TO CONSERVATION AND MANAGEMENT OF SEABIRDS to predation by introduced Norway rats (Rattus norvegicus). In 2001 and 2002 the auklet colony experienced the lowest reproductive success ever recorded for auklets. Norway rats have been suggested as the cause

Jones, Ian L.

3

Differences Between Golden Hamsters (Mesocricetus auratus) and Norway Rats (Rattus norvegicus) in Preference for the Sole Diet That  

E-Print Network [OSTI]

- ferred the food with the unfamiliar flavor. In contrast, Norway rats (Rattus norvegicus) examined under found that, in a variety of circumstances, rats exhibited robust reductions in preference for the foodDifferences Between Golden Hamsters (Mesocricetus auratus) and Norway Rats (Rattus norvegicus

Galef Jr., Bennett G.

4

IMPACTS OF INTRODUCED NORWAY RATS (RATTUS NORVEGICUS) ON LEAST AUKLETS (AETHIA PUSILLA) BREEDING AT KISKA ISLAND,  

E-Print Network [OSTI]

IMPACTS OF INTRODUCED NORWAY RATS (RATTUS NORVEGICUS) ON LEAST AUKLETS (AETHIA PUSILLA) BREEDING 2004 #12;ii ABSTRACT I quantified impacts of non-indigenous Norway rats on Least Auklets breeding at Kiska Island. Little direct evidence of rat predation was found in my productivity crevices

Jones, Ian L.

5

Lack of Interference in Long-Term Memory for Socially Learned Food Preferences in Rats (Rattus norvegicus)  

E-Print Network [OSTI]

Lack of Interference in Long-Term Memory for Socially Learned Food Preferences in Rats (Rattus had no measurable effect on rats' socially learned food preferences. The stability of socially-identifying cues that either come from particles of recently eaten food clinging to the fur of a rat or escape from

Galef Jr., Bennett G.

6

Copyright 1998 Psychonomic Society, Inc. 76 Colonies of Norway rats (Rattus norvegicus) in large  

E-Print Network [OSTI]

so may allow rats to find food efficiently. Other fac- tors that could have favored path following these traits al- lowed rats to orient in the environment and to economi- cally gather food from spatially separated food patches. Empirical support for the hypothesis that rats can use paths to economically forage

Timberlake, William D.

7

E-Print Network 3.0 - anaesthetized female rat Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: rattus, (22 female, 8 male; 1 escaped before sexing); 4 were Norway rats, Rattus norvegicus (1 female, 3... rats handled under anaesthetic was four out of nine,...

8

Experimental Inoculation of Male Rats with Coxiella burnetii: Successful Infection but No Transmission to Cage Mates  

Science Journals Connector (OSTI)

...Microbiology Experimental Inoculation of Male Rats with Coxiella burnetii: Successful Infection...study was to investigate whether brown rats (Rattus norvegicus) can be experimentally...cage mates occurs. Fourteen male brown rats (wild type) were intratracheally or intranasally...

Marieke Opsteegh; Lenny Hogerwerf; Stephane Nooijen; Cecile Dam-Deisz; Lianne de Heer; Chantal Reusken; Annemarie Bouma; Hendrik-Jan Roest; Mirjam Nielen; Joke van der Giessen

2012-06-08T23:59:59.000Z

9

Explaining social learning of food preferences without aversions: an evolutionary simulation model of Norway rats  

Science Journals Connector (OSTI)

...evolutionary simulation model of Norway rats Jason Noble * Peter M. Todd Elio Tucif...Lentzeallee 94, 14195, Berlin, Germany Norway rats (Rattus norvegicus) transmit preferences...smelling each other's breath. However, rats fail to learn aversions, acquiring a preference...

2001-01-01T23:59:59.000Z

10

Characterization and Mapping of the Gene Conferring Resistance to Rift Valley Fever Virus Hepatic Disease in WF.LEW Rats  

E-Print Network [OSTI]

Rift Valley Fever Virus is a plebovirus that causes epidemics and epizootics in sub-Saharan African countries but has expanded to Egypt and the Arabian Peninsula. The laboratory rat (Rattus norvegicus) is susceptible to RVFV and has been shown...

Callicott, Ralph J.

2010-01-14T23:59:59.000Z

11

Cloning and sequencing of full-length MCT1 and a smaller splice variant from rat colon tissues  

Science Journals Connector (OSTI)

...preferred metabolic fuel providing about 60% of the colonocytes energy requirements. In vivo studies have correlated butyrate levels...sequence that was previously reported for the lung tissues of the Norway rats (Rattus norvegicus). The sequence of the smaller fragment...

Praveen K. Rathinavelu; Qiao Tong; Madhusudhanan Narasimhan; Vazhaikurichi M. Rajendran; Henry J. Binder; and Appu Rathinavelu

2005-05-01T23:59:59.000Z

12

Anim. Behav., 1997, 54, 705714 Socially acquired information reduces Norway rats' latencies to find food  

E-Print Network [OSTI]

rats, Rattus norvegicus, look for food and what foods they eat. The present studies were undertaken to determine whether rats could also use information acquired from conspecifics to determine when food had forager. Furthermore, naive rats that had been trained to eat a food, but not naive rats trained to avoid

Galef Jr., Bennett G.

13

Assessing the effects of Norway rats on auklet breeding success and survival at Sirius Point, Kiska  

E-Print Network [OSTI]

Assessing the effects of Norway rats on auklet breeding success and survival at Sirius Point, Kiska-8141 FAX: (709) 737-2410 e-mail: carie@mun.ca #12;Eggleston and Jones Kiska auklet-rat monitoring in 2006 2 Introduction The presence of introduced Norway rats (Rattus norvegicus) has been implicated as a possible

Jones, Ian L.

14

A Theoretically Based Model of Rat Personality with Implications for Welfare  

E-Print Network [OSTI]

A Theoretically Based Model of Rat Personality with Implications for Welfare Becca Franks*, E. Tory from zoo-housed primates and laboratory rats has suggested that it may be applicable to nonhuman animal behavior as well. Building on these initial studies, we collected data on 60 rats, Rattus norvegicus

Champagne, Frances A.

15

Effects of environmental stability and demonstrator age on social learning of food preferences by young Norway rats  

E-Print Network [OSTI]

online 25 August 2004; MS. number: A9636) We used socially learned food preferences of Norway rats. However, food choices of rats that were moved daily from one cage to another and fed at unpredictable learning of food preferences by Norway rats, Rattus norvegicus, a species that has served for several

Galef Jr., Bennett G.

16

The laboratory rat strains most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia  

E-Print Network [OSTI]

Rats History The laboratory rat strains most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia and the family Muridae. Adult rats generally weigh between 200 and 400 g, with males significantly larger than

Shihadeh, Alan

17

Invasive rats and recent colonist birds partially compensate for the loss of endemic New Zealand pollinators  

Science Journals Connector (OSTI)

...research-article Research articles 1001 60 Invasive rats and recent colonist birds partially compensate...species in New Zealand, the invasive ship rat (Rattus rattus) and the recent colonist...invasive mammalian predators (such as ship rats Rattus rattus, stoats Mustela ermina and...

2012-01-01T23:59:59.000Z

18

E-Print Network 3.0 - alternative diet therapy Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Ecology ; Geosciences 37 Lack of Interference in Long-Term Memory for Socially Learned Food Preferences in Rats (Rattus norvegicus) Summary: provided each observer with ad...

19

E-Print Network 3.0 - anticoagulant-susceptible norway rats Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Gary Greenberg Summary: rats will acquire the traditional pattern of behavior. Food Preference and Poison Avoidance by Norway... - tions of Norway rats (Rattus...

20

E-Print Network 3.0 - adult rats effects Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

1995 Summary: Society of New Zealand 1995 291 Ranging behaviour of forest-dwelling ship rats, Rattus rattus, and effects... second aim was to investigate the effect of the...

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Detection of Zoonotic Pathogens and Characterization of Novel Viruses Carried by Commensal Rattus norvegicus in New York City  

Science Journals Connector (OSTI)

...SignalP 4.1, all of which were accessed through the ExPASy web portal (http://www.expasy.org). RNA secondary structures...doi: 10.1093/molbev/mss075 . 75. Zuker M . 2003. Mfold web server for nucleic acid folding and hybridization prediction...

Cadhla Firth; Meera Bhat; Matthew A. Firth; Simon H. Williams; Matthew J. Frye; Peter Simmonds; Juliette M. Conte; James Ng; Joel Garcia; Nishit P. Bhuva; Bohyun Lee; Xiaoyu Che; Phenix-Lan Quan; W. Ian Lipkin

2014-10-01T23:59:59.000Z

22

Detection of Zoonotic Pathogens and Characterization of Novel Viruses Carried by Commensal Rattus norvegicus in New York City  

Science Journals Connector (OSTI)

...0.023 () L.-interrogans 16 (12) Brain (0/133) Bladder (1/97) Kidney...0/133) Bladder/urine (0/133) Brain (6/133) Kidney (7/133) Liver...fecal samples), Rickettsia spp. (brain, kidney, serum, and spleen samples...

Cadhla Firth; Meera Bhat; Matthew A. Firth; Simon H. Williams; Matthew J. Frye; Peter Simmonds; Juliette M. Conte; James Ng; Joel Garcia; Nishit P. Bhuva; Bohyun Lee; Xiaoyu Che; Phenix-Lan Quan; W. Ian Lipkin

2014-10-01T23:59:59.000Z

23

Detection of Zoonotic Pathogens and Characterization of Novel Viruses Carried by Commensal Rattus norvegicus in New York City  

Science Journals Connector (OSTI)

...swabs (Puritan Medical Products Company, Guilford, ME), and fecal pellets...Cueto GR and Suarez OV. 2009. Changes in rodent communities according...2010. Potential influence of climate change on vector-borne and zoonotic...

Cadhla Firth; Meera Bhat; Matthew A. Firth; Simon H. Williams; Matthew J. Frye; Peter Simmonds; Juliette M. Conte; James Ng; Joel Garcia; Nishit P. Bhuva; Bohyun Lee; Xiaoyu Che; Phenix-Lan Quan; W. Ian Lipkin

2014-10-01T23:59:59.000Z

24

Detection of Zoonotic Pathogens and Characterization of Novel Viruses Carried by Commensal Rattus norvegicus in New York City  

Science Journals Connector (OSTI)

...genera and adopted a minimum-energy RNA secondary structure that...on discarded food scraps and household waste, the presence of common...captured in an urban area of Japan. Parasitol. Res. 100 :1417-1420...infection of pets within a household with three Bartonella species...

Cadhla Firth; Meera Bhat; Matthew A. Firth; Simon H. Williams; Matthew J. Frye; Peter Simmonds; Juliette M. Conte; James Ng; Joel Garcia; Nishit P. Bhuva; Bohyun Lee; Xiaoyu Che; Phenix-Lan Quan; W. Ian Lipkin

2014-10-01T23:59:59.000Z

25

Marine Ornithology 41: 4148 (2013) Bond et al.: Crested Auklet survival with Norway Rats 41  

E-Print Network [OSTI]

Marine Ornithology 41: 41­48 (2013) Bond et al.: Crested Auklet survival with Norway Rats 41 (Jones et al. 2008, Towns et al. 2011). Introduced rats (Rattus spp.) cause reduced breeding success al. 2008, Lavers et al. 2010). However, deciphering and quantifying the effect of rats on seabird

Jones, Ian L.

26

Rats  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Rats Rats Nature Bulletin No. 81 August 31, 1946 Forest Preserve District of Cook County Clayton F. Smith, President Roberts Mann, Superintendent of Conservation RATS Rats and men have been at war since the dawn of history. The "cradle of mankind" Central Asia, apparently was also the place of origin of the rat. From there, living and traveling with man, it has spread over the globe. In the United States today there are about as many rats as there are people. Cur common rat is the Norway or brown rat which arrived here from Europe before the Revolutionary War. Fiercer and more cunning, it soon exterminated the black rat and the roof rat which had migrated here with the early colonists and thrived. The black rat -- which is glossy black above, smaller and more slender -- and the roof rat, a close relative, are found now only rarely in some of the southern states, although still common in tropical America.

27

A new way to study teaching in animals: despite demonstrable benefits, rat dams do not teach their young what to eat  

E-Print Network [OSTI]

by mothers would be effective, if it occurred. We examined food choices of rat dams trained to eat one of twoA new way to study teaching in animals: despite demonstrable benefits, rat dams do not teach taught are large. Here, we determined, first, whether Rattus novegicus dams would modify their food

Galef Jr., Bennett G.

28

E-Print Network 3.0 - adult rats rattus Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Ecology ; Biology and Medicine 29 Historical Mammal Extinction on Christmas Island (Indian Ocean) Correlates with Introduced Infectious Disease Summary: . A case in point is...

29

E-Print Network 3.0 - albino rats rattus Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Streeper, N. M. (2002). Thermoregulatory behavior in infant Norway ... Source: Blumberg, Mark - Department of Psychology, University of Iowa Collection: Biology and Medicine 34...

30

Supplement 22, Part 5, Parasite-Subject Catalogue, Parasites: Arthropoda and Miscellaneous Phyla  

E-Print Network [OSTI]

(64) , 37-67 Rattus rattus: Lelydorp, Surinam Rattus rattus frugivorus: Brokubaka, Surinam Afrolistrophorus mediolineatus sp. n. Fain, ?., 1976, Acta Zool. et Path. Antverpi- ensia (64), 37-67 bandicoot rat: Ban Thenon, 18 Km NW Kieng- Kwang...

Zidar, Judith A.; Shaw, Judith H.; Hanfman, Deborah T.; Kirby, Margie D.; Rayburn, Jane D.; Edwards, Shirley J.; Hood, Martha W.

1981-01-01T23:59:59.000Z

31

Index of /images/rat/rat.seq  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

rat/rat.seq rat/rat.seq Parent Directory rat.seq.1.tif rat.seq.10.tif rat.seq.100.tif rat.seq.101.tif rat.seq.102.tif rat.seq.103.tif rat.seq.104.tif rat.seq.105.tif rat.seq.106.tif rat.seq.107.tif rat.seq.108.tif rat.seq.109.tif rat.seq.11.tif rat.seq.110.tif rat.seq.111.tif rat.seq.112.tif rat.seq.113.tif rat.seq.114.tif rat.seq.115.tif rat.seq.116.tif rat.seq.117.tif rat.seq.118.tif rat.seq.119.tif rat.seq.12.tif rat.seq.120.tif rat.seq.121.tif rat.seq.122.tif rat.seq.123.tif rat.seq.124.tif rat.seq.125.tif rat.seq.126.tif rat.seq.127.tif rat.seq.128.tif rat.seq.129.tif rat.seq.13.tif rat.seq.130.tif rat.seq.131.tif rat.seq.132.tif rat.seq.133.tif rat.seq.134.tif rat.seq.135.tif rat.seq.136.tif rat.seq.137.tif rat.seq.138.tif rat.seq.139.tif rat.seq.14.tif rat.seq.140.tif rat.seq.141.tif rat.seq.142.tif

32

Rat Deterrent  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Rat Deterrent Rat Deterrent Name: mike Location: N/A Country: N/A Date: N/A Question: my friends have a house with a basement, they have seen rats coming from cider blocks that are open at the top ,and on inspection with a mirror seem to go all the down to the foundation, i suggested maybe putting moth balls down the blocks to help out if they are coming from the botton up, they have a new baby in the house, will this hurt anyone or cause harm? thanks Replies: Moth balls are not going to hurt anyone, but they are not going to solve the problem either. Rats are serious pests that will not be deterred by moth balls and a permanent solution, sealing up access points after removing the rats, will be needed. J. Elliott Stuff the holes with steel wool. It's not poisonous, it's cheap, and rats can't chew through it.

33

E-Print Network 3.0 - als3p protects mice Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

to mice and rats. In Utah, house mice (Mus musculus) and Norway rats (Rattus... of house mice and Norway rats. House mice are ... Source: Berryman Institute, Department of...

34

RATS VERSUS PEOPLE Rats equal twice  

E-Print Network [OSTI]

from rats to man and to other animals. Amebiasis, infectious jaun- dice, Salmonella food poison- ing, and tapeworm infections are spread by rats. The germs are transmitted to man by polluted_food and water. Rat. Rats will gnaw through almost anything in their path to obtain food. Hard substances ~ like concrete

35

E-Print Network 3.0 - acyltransferase-2 protects mice Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Utah, house mice (Mus musculus) and Norway rats (Rattus... of house mice and Norway rats. House mice are ... Source: Berryman Institute, Department of Fisheries and Wildlife, Utah...

36

Controlling Rats and Mice  

E-Print Network [OSTI]

House rats and mice eat and contaminate human and animal food, and they damage and destroy property. This leaflet explains how to identify rats and mice by their droppings, runways, food crumbs and noises. Various control methods are discussed....

Texas Wildlife Services

2007-03-13T23:59:59.000Z

37

Maze preferences in naive rats produced by injection of ribonucleic acid from trained rats  

Science Journals Connector (OSTI)

One group of rats was trained with food reward to choose ... was extracted from the brains of these trained rats and was injected into untrained rats. On subsequent unreinforced test trials the untrained rats sho...

Allan L. Jacobson; Frank R. Babich; Suzanne Bubash; Carolyn Goren

1966-01-01T23:59:59.000Z

38

9 - Production of Transgenic Rats  

Science Journals Connector (OSTI)

The procedures for production of transgenic rats, in comparison to transgenic mice, while widely used are less available. The rat is a very important species for the production of animal models of human disease and physiology. In many ways, the rat is model of choice for studies of human disease. There is more than a century of papers published with extensive phenotypic data from the rat. With more than 250 strains of rat which include inbred strains, congenics, mutants, transgenics, and now targeted loss of function mutations, there are important animals available for the study of cardiopulmonary disease and physiology, renal disease, and physiology.

Philip Iannaccone; Vasiliy Galat

2014-01-01T23:59:59.000Z

39

Super Rat Poison Man  

E-Print Network [OSTI]

Bob Square Tie. But Zheng Xiaoyu, the deposed head of China's State Food and Drug Administration begs to be excused. A rat poison manufacturer here in China applied for permission to name some of its products after him, partly because he's corrupt...

Hacker, Randi; Tsutsui, William

2007-04-04T23:59:59.000Z

40

Impulsive Rats are Less Vedran Lovic1  

E-Print Network [OSTI]

Impulsive Rats are Less Maternal Vedran Lovic1 Daniela J. Palombo2 Alison S. Fleming3 1 Department and physiology. Previously, we found that compared to mother- reared (MR) female rats, rats reared without(1), 11�42]. We also found that AR rats are more action impulsive and have reduced attentional capacities

Sokolowski, Marla

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Base 10 RATS Cycles and Arbitrarily Long Base 10 RATS Cycles  

Science Journals Connector (OSTI)

John Conway invented a digital game called RATS [1], an acronym for Reverse, Add, Then Sort. A game of RATS produces a sequence of positive integers. The ... nondecreasing order. The first number in a RATS sequen...

Curtis Cooper; Robert E. Kennedy

1999-01-01T23:59:59.000Z

42

Role of Prostaglandins in Experimental Ischemic Brain Edema in Hypertensive Rats: TXA2 Priority in Hypertensive Rats  

Science Journals Connector (OSTI)

Hypertensive rats are known to be more susceptible to ischemic insults than normotensive rats [1, 2], but the reason...

S. Sugimoto; A. Terashi; Y. Katayama; M. Mizoguchi; T. Soeda; K. Inamura

1985-01-01T23:59:59.000Z

43

Live Demo: Spiking ratSLAM: Rat Hippocampus Cells in Spiking Neural Hardware  

E-Print Network [OSTI]

complex mazes and remember the location of home and food, rats take advantage a cells in the hippocampusLive Demo: Spiking ratSLAM: Rat Hippocampus Cells in Spiking Neural Hardware F. Galluppi l , J Abstract-We will demonstrate a model of rat hippocampus place, grid and Border cells implemented

Kuehnlenz, Kolja

44

Social Influences on Rat Spatial Choice Social Influences on Rat Spatial Choice  

E-Print Network [OSTI]

of spatial working memory paradigms using pairs of laboratory rats foraging together for food depleted of food by the other rat. The latter effect is based on working memory for the choices madeSocial Influences on Rat Spatial Choice Social Influences on Rat Spatial Choice Michael F. Brown

Cook, Robert

45

Chronic stress elevates telomerase activity in rats  

Science Journals Connector (OSTI)

...Chronic stress elevates telomerase activity in rats Annaliese K. Beery 1 * Jue Lin 2 Joshua...unpredictable stress on telomerase activity in male rats. Telomerase activity was 54 per cent higher in stressed rats than in controls, and associated with stress-related...

2012-01-01T23:59:59.000Z

46

THE BEHAVIOR OF THE LABORATORY RAT  

E-Print Network [OSTI]

-living rats and their young can de- termine which foods the young come to eat. I then describe very briefly ANALOGUE Avoidance by young wild rats of a food that adults of their colony have learned to avoid eatingTHE BEHAVIOR OF THE LABORATORY RAT A Handbook with Tests Edited by IAN Q. WHISHAW BRYAN KOl

Galef Jr., Bennett G.

47

Gene therapy in alcoholic rats  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

70 70 Sept. 9, 2001 Gene Therapy Reduces Drinking in "Alcoholic" Rats UPTON, NY - Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have shown that increasing the level of a brain protein important for transmitting pleasure signals can turn rats that prefer alcohol into light drinkers, and those with no preference into near teetotalers. The findings, published in the first September 2001 issue of the Journal of Neurochemistry (Vol. 78, No. 5), may have implications for the prevention and treatment of alcoholism in humans. "This is a preliminary study, but when you see a rat that chooses to drink 80 to 90 percent of its daily fluid as alcohol, and then three days later it's down to 20 percent, that's a dramatic drop in alcohol intake - a very clear change in behavior," said Panayotis Thanos, the lead researcher. "This gives us great hope that we can refine this treatment for future clinical use."

48

E-Print Network 3.0 - adult male rats Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

rats Search Powered by Explorit Topic List Advanced Search Sample search results for: adult male rats...

49

E-Print Network 3.0 - adult female rats Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

rats Search Powered by Explorit Topic List Advanced Search Sample search results for: adult female rats...

50

Diurnal Variations in Lymphocyte Subpopulations in Lymphoid Organs of Rats with Genetic Catalepsy and Wistar Rats  

Science Journals Connector (OSTI)

Parameters of the immune status of the thymus and spleen in rats with genetic catalepsy were lower compared to those in Wistar rats. Diurnal variations in cell subpopulations of lymphoid ... strains. Behavioral c...

N. G. Panteleeva; N. I. Gryazeva

2004-03-01T23:59:59.000Z

51

Modulation of rat behaviour by using a rat-like robot  

Science Journals Connector (OSTI)

In this paper, we study the response of a rat to a rat-like robot capable of generating different types of behaviour (stressful, friendly, neutral). Experiments are conducted in an open-field where a rat-like robot called WR-4 is put together with live rats. The activity level of each rat subject is evaluated by scoring its locomotor activity and frequencies of performing rearing (rising up on its hind limbs) and body grooming (body cuddling and head curling) actions, whereas the degree of preference of that is indicated by the robotrat distance and the frequency of contacting WR-4. The moving speed and behaviour of WR-4 are controlled in real-time based on the feedback from rat motion. The activity level and degree of preference of rats for each experimental condition are analysed and compared to understand the influence of robot behaviour. The results of this study show that the activity level and degree of preference of the rat decrease when exposed to a stressful robot, and increase when the robot exhibit friendly behaviour, suggesting that a rat-like robot can modulate rat behaviour in a controllable, predictable way.

Qing Shi; Hiroyuki Ishii; Shinichi Kinoshita; Atsuo Takanishi; Satoshi Okabayashi; Naritoshi Iida; Hiroshi Kimura; Shigenobu Shibata

2013-01-01T23:59:59.000Z

52

Ethanol Consumption by Rat Dams During Gestation,  

E-Print Network [OSTI]

Ethanol Consumption by Rat Dams During Gestation, Lactation and Weaning Increases Ethanol examined effects of ethanol consumption in rat dams during gestation, lactation, and weaning on voluntary ethanol consumption by their adolescent young. We found that exposure to an ethanol-ingesting dam

Galef Jr., Bennett G.

53

Weaninqc in Rats: 11. Pup Behavior Patterns  

E-Print Network [OSTI]

Weaninqc in Rats: 11. Pup Behavior Patterns EDDA THIELS JEFFREY R. ALBERTS Department of Psychology Hanover, New Hampshire In this study, litters of rat pups and their mothers were continuously video that period. Prior to the onset of solid food intake (Day 18). pups spent most of their active time suckling

54

Weaning in Rats: I. Maternal Behavior  

E-Print Network [OSTI]

Weaning in Rats: I. Maternal Behavior CATHERINE P. CRAMER Department of Psychology Dartmouth videorecordings of Norway rat dams and their litters. Time spent nursing declined steadily after Day 20 foods. Weaning is the transition between these two forms of subsistence and constitutes an essential

55

The Metabolism of Americium in the Rat  

E-Print Network [OSTI]

t _ 'mE METABOLISM OF AMERICIUM IN THE RAT* By K. G. Scott,The distri :.1). tl.on of americium in the bone was studied,48A THE METABOLISM OF AMERICIUM IN THE RAT By K. G. Scott,

Scott, K.G.

2010-01-01T23:59:59.000Z

56

Arrhythmias in Rat Hearts Exposed to Pulsed Ultrasound  

E-Print Network [OSTI]

Arrhythmias in Rat Hearts Exposed to Pulsed Ultrasound After Intravenous Injection of a Contrast. Conduction complex and heart lesion data were recorded from 20 rats that received intravenous injections of 0 rats. When ultrasound exposure was halted, arrhythmias ceased but reoccurred in 4 of the 10 rats when

Illinois at Urbana-Champaign, University of

57

Perinatal Undernutrition: Accumulation of Catecholamines in Rat Brain  

E-Print Network [OSTI]

of the pregnant· rats consumed food containing 8 per- cent protein: half were fed 24 percent protein (6). ThusPerinatal Undernutrition: Accumulation of Catecholamines in Rat Brain Abstract. Brains of rats in the brains of rats (2) and children (3). This decrease could reflect changes in the number of neurons

Wurtman, Richard

58

Supplement 22, Part 5, Parasite-Subject Catalogue, Parasites: Arthropoda And Miscellaneous Phyla  

E-Print Network [OSTI]

-67 Rattus sabanus vociferans: Gunong Benom, Pahang, Malaysia Afrolistrophorus maculatus ssp. rattus ssp. n. Fain, ?., 1976, Acta Zool. et Path. Antverpi- ensia (64) , 37-67 Rattus rattus: Lelydorp, Surinam Rattus rattus frugivorus: Brokubaka, Surinam...

Edwards, Shirley J.; Hood, Martha W.; Shaw, Judith H.; Rayburn, Jane D.; Kirby, Margie D.; Hanfman, Deborah T.; Zidar, Judith A.

1981-01-01T23:59:59.000Z

59

Arginine metabolism in enterocytes of diabetic rats  

E-Print Network [OSTI]

Diabetic rats and patients exhibit decreased plasma arginine concentrations. Arginine is important in numerous cellular pathways, including the synthesis of nitric oxide and the release of insulin from pancreatic ? cells. At present, little...

Morrow, Natalie Anne

2012-06-07T23:59:59.000Z

60

The Metabolism of Curium in the RAT  

E-Print Network [OSTI]

G. , "The Metabolism of Americium in the Rat", Jour. Clin.of the metabOlism of americium has been reported in.is also radloacti ve. Americium and curium are not available

Hamilton, J.

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

TRACTOGRAPHY OF FORNIX, CINGULUM, AND CORPUS CALLOSUM IN RAT BRAIN  

E-Print Network [OSTI]

was performed and visually inspected for anatomical correctness according to a rat atlas brain. Values of Trace as the effects of pharmacological drugs on white matter. DISCUSSION Figure 4: Trace, FA, RD, and AD Figure 1: Rat

62

Effect of heparin on activity of oxidative enzyme systems of liver microsomes in healthy rats and rats with experimental glomerulonephritis  

Science Journals Connector (OSTI)

To study the effect of heparin on activity of the oxidative enzyme systems of the liver microsomes of healthy rats and of rats with glomerulonephritis the hexobarbital test was carried...450 in the liver and the ...

Z. T. Samoilova; V. V. Klimenko

1978-04-01T23:59:59.000Z

63

Neutron-induced Mammary Neoplasms in the Rat  

Science Journals Connector (OSTI)

...female Sprague-Dawley rat. Other workers have established a linear relationship...female Sprague-Dawley rat. Other workers have established a linear relationship...irradiated several groups of rats at the Oak Ridge Health Physics Reactor to a single...

Howard H. Vogel, Jr. and Robert Zaldvar

1972-05-01T23:59:59.000Z

64

The influence of magnesium deficiency on inflammatory reaction in rats  

E-Print Network [OSTI]

The influence of magnesium deficiency on inflammatory reaction in rats Régine DELAIGUE, P. DUCHENE, France. Summary. The inflammatory reactions obtained in magnesium-deficient rats, by injecting of inflammatory reactions observed in magnesium- deficient rats could not be explained only by histamine

Paris-Sud XI, Université de

65

Fatal attraction in rats infected with Toxoplasma gondii  

Science Journals Connector (OSTI)

...research-article Fatal attraction in rats infected with Toxoplasma gondii M. Berdoy...manipulates the behaviour of its intermediate rat host in order to increase its chance of...cycle. Here we report that, although rats have evolved anti-predator avoidance...

2000-01-01T23:59:59.000Z

66

Graded Effects of Proteinuria on HDL Structure in Nephrotic Rats  

E-Print Network [OSTI]

Graded Effects of Proteinuria on HDL Structure in Nephrotic Rats Gregory C. Shearer,* John W isolated from rats with massive proteinuria is depleted in apolipoprotein E (apoE). It is unknown at what on apolipoproteins other than apoE. Two models of albuminuria were used in Sprague-Dawley rats: Adriamycin

Hammock, Bruce D.

67

SCHOOLS INTEGRATED PEST MANAGEMENT (IPM) FOR RATS *Important Note*  

E-Print Network [OSTI]

SCHOOLS INTEGRATED PEST MANAGEMENT (IPM) FOR RATS AND MICE *Important Note* According on school grounds. INTRODUCTION Rats and mice can be a major pest problem in schools. They damage food, books, documents, and clothing. Damage to a structure occurs when rats and mice gnaw on structural

Liskiewicz, Maciej

68

Motherless Rats Show Deficits in Maternal Behavior Towards  

E-Print Network [OSTI]

Motherless Rats Show Deficits in Maternal Behavior Towards Fostered Pups Daniela J. Palombo1.fleming@utoronto.ca ABSTRACT: Complete maternal deprivation in rats, through artificial rearing (AR), produces deficits 52: 142�148, 2010. Keywords: rat; artificial rearing; early experience; development; maternal

Sokolowski, Marla

69

Spatial working memory in rats: no differences between the sexes  

Science Journals Connector (OSTI)

...November 1999 research-article Spatial working memory in rats: no differences between the sexes Susan D Healy 1 2...spatial learning and memory abilities of male and female rats. The rats were tested across a number of consecutive days during...

1999-01-01T23:59:59.000Z

70

Placental 11 -Hydroxysteroid Dehydrogenase in Dahl and Spontaneously Hypertensive Rats  

E-Print Network [OSTI]

Placental 11 -Hydroxysteroid Dehydrogenase in Dahl and Spontaneously Hypertensive Rats Karla Mazancova, Ivan Miksik, Jaroslav Kunes, and Jiri´ Pa´ cha Studies in normotensive rats showed that excessive hypertensive (SHR) and Dahl salt-sensitive rats (DS) and their normotensive counterparts Wistar-Kyoto (WKY

Miksik, Ivan

71

Original article Digestion and fermentation of proteins in rats fed  

E-Print Network [OSTI]

Original article Digestion and fermentation of proteins in rats fed keratin, albumin, cooked casein) Summary ― Dietary cooked casein promotes colon cancer in rats. We speculated and tested (hydrolysed or not) and bovine serum albumin (oxidized or not) was measured in rats. Protein fermentation

Boyer, Edmond

72

Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 2. Colistin  

Science Journals Connector (OSTI)

...Characterization of Nebulized Antimicrobial Agents in Rats: 2. Colistin Aline Vidal Lacerda Gontijo...intrapulmonary administration of colistin sulfate in rats. Colistin was infused or delivered in...dose of 0.35 mg/kg of body weight in rats, and plasma drug concentrations were measured...

Aline Vidal Lacerda Gontijo; Nicolas Grgoire; Isabelle Lamarche; Patrice Gobin; William Couet; Sandrine Marchand

2014-05-05T23:59:59.000Z

73

ESTROGEN-GONADOTROPIN INTERACTION IN POSTNATAL FEMALE RATS,  

E-Print Network [OSTI]

ESTROGEN-GONADOTROPIN INTERACTION IN POSTNATAL FEMALE RATS, AND THE INDUCTION OF ANOVULATORY) - ---- SUMMARY Ten days old female Sprague-Dawley rats were treated with bilateral adrenalectomy (ADX,474 lowered serum levels of LH and FSH. Another group of female rats was treated with LC.I. 46,474 from day 5

Paris-Sud XI, Université de

74

Anthocyanins in Black Raspberries Prevent Esophageal Tumors in Rats  

Science Journals Connector (OSTI)

...Raspberries Prevent Esophageal Tumors in Rats Li-Shu Wang 1 Stephen S. Hecht 3 Steven...N-nitrosomethylbenzylamine (NMBA)-induced tumors in the rat esophagus. Using bioassay-directed fractionation...chemopreventive activity of BRB in vivo. F344 rats consumed diets containing either (a...

Li-Shu Wang; Stephen S. Hecht; Steven G. Carmella; Nanxiong Yu; Bethany Larue; Cassandra Henry; Colleen McIntyre; Claudio Rocha; John F. Lechner; Gary D. Stoner

2009-01-01T23:59:59.000Z

75

Huddling and Independent Feeding of Neonatal Rats Can be  

E-Print Network [OSTI]

during testing. Hall (1979) has shown that when food-deprived newborn rats ingest milk delivered throughHuddling and Independent Feeding of Neonatal Rats Can be Facilitated by a Conditioned Change CHRISTINA L. WILLIAMS Barnard College of Columbia University New York, New York Infant rat pups were exposed

Sullivan, Regina M.

76

Weaning in the Norway Rat: Relation Between Sucklinqc and-  

E-Print Network [OSTI]

of milk to exclusive ingestion of solid food in weaning-age rat pups (Babicky, Ostadalova, ParizekWeaning in the Norway Rat: Relation Between Sucklinqc and- Milk, and Suckling and Independent examined in rat pups the relation between the decline of suckling and the emergence of independent

77

Scatter hoarding by kangaroo rats (Dipodomys merriami) and  

E-Print Network [OSTI]

discovery increases with spacing and with proximity to perennial shrubs. Nine kangaroo rats cached dyed food was more secure from pilferage than food initially scattered, and yet kangaroo rats were observedScatter hoarding by kangaroo rats (Dipodomys merriami) and pilferage from their caches Martin Daly

Jacobs, Lucia

78

Studies of Social Learning in Norway Rats: A Brief Review  

E-Print Network [OSTI]

in the transmission of karncd food preferences from adult rats to their young. The 2nd examines the possibility that the habit of diving in shallow watcr for food is socially transmitted from I rat to iJnother. In the decadesStudies of Social Learning in Norway Rats: A Brief Review BENNETT G. GALEF, JR. DC/Jartment 0/ P

Galef Jr., Bennett G.

79

Morphological peculiarities of juxtaglomerular apparatus of the kidney in rats with hereditary stress-induced arterial hypertension (NISAG rats)  

Science Journals Connector (OSTI)

Structure of juxtaglomerular apparatus of the kidney in NISAG rats and morphometric parameters of renin-producing juxtaglomerular,...

N. P. Kazarinov; M. D. Shmerling

1999-05-01T23:59:59.000Z

80

Viability of adult rat skin following 13 Mev proton irradiation  

E-Print Network [OSTI]

then removed from suspension by centrifugation and washed twice in Smith's chick heart growth media. 33 All cells removed from the biopsy by this enzyme dissection were placed in culture to check viability. Two Rose chambers con- taining the first scraping... Dissipation . Diagram ? Proton Energy Dissipation 17 17 Cell Suspension Filter Tube. Exploded View of Rose Chamber 24 Rat 822, Gross Appearance 37 SB. Rat 822, Skin Section. 38 Rat 771, Gross Appearance 37 Rat 771, Skin Section. 38 7A. 7B. Rat 835...

Caraway, Bobby Lamar

1966-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Circulating Rat Platelets in Lethally X-radiated Mice Given Rat Bone Marrow  

Science Journals Connector (OSTI)

...MAKINODAN,ANDC. C. CONGDON (Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennestee) By the use of immunohematological...given injections of rat bone marrow. These same workers also identified a distinctive chromo some in dividing...

L. H. Smith; T. Makinodan; and C. C. Congdon

1957-06-01T23:59:59.000Z

82

Percutaneous penetration of uranium in rats after a contamination on intact or wounded skin  

Science Journals Connector (OSTI)

......hairless rats. Percutaneous penetration through wounded skin towards...1157-1165. Percutaneous penetration of uranium in rats after a...hairless rats. Percutaneous penetration through wounded skin towards...Kinetics Male Metabolic Clearance Rate Models, Biological Radiometry......

F. Petitot; C. Gautier; A. M. Moreels; S. Frelon; F. Paquet

2007-11-01T23:59:59.000Z

83

E-Print Network 3.0 - aged rat erectile Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Receptors in the Diabetic Rat Serap Gur... nucleotides in erectile function in diabetic rats. Materials and Methods: A total of 60 adult male rats were... at age 50 years.9 Since...

84

Three-dimensional space: locomotory style explains memory differences in rats and hummingbirds  

Science Journals Connector (OSTI)

...locomotory style explains memory differences in rats and hummingbirds I. Nuri Flores-Abreu 1 T. Andrew...In the cubic mazes in which we trained and tested rats and hummingbirds, rats moved more vertically than horizontally, whereas...

2014-01-01T23:59:59.000Z

85

intestine of the holoxenic rat. In each group of rats, the bile acid composition observed in the small intestine and in the bile is different.  

E-Print Network [OSTI]

intestine of the holoxenic rat. In each group of rats, the bile acid composition observed in the small intestine and in the bile is different. When holoxenic and gnotoxenic rats were provided was not observed in the gnotoxenic rat : therefore, presence of deoxycholic acid does not appear to be necessary

Paris-Sud XI, Université de

86

E-Print Network 3.0 - adult rat dentate Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

dentate spikes were collected in the still alert rat and during slow- wave sleep. Two types... from 4 rats with similar medio-lateral and longitudinal electrode ... Source:...

87

Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Nicotine in Rat Brain Tissue by Use of Nanospray Desorption Electrospray Ionization Mass Spectrometry. Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption...

88

E-Print Network 3.0 - african giant rat Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

rat mhanga ant bear pofu eland (largest... milia. I dislike rhinoceroses, giant rats, buffalo, and zebras. 12; 3. Kuna vivutio gani vya watalii... of the antelopes)...

89

E-Print Network 3.0 - anesthetized male rats Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

male rats Search Powered by Explorit Topic List Advanced Search Sample search results for: anesthetized male rats Page: << < 1 2 3 4 5 > >> 1 Preparation of Immediately Centrifuged...

90

E-Print Network 3.0 - adult rat sciatic Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

SCHMALBRUCH, H. (1984). Motoneurone death after sciatic nerve section in newborn rats. J... Nerve Injury on the Expression of Heat Shock Proteins in Developing Rat ......

91

E-Print Network 3.0 - acute rat infarct Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

dog) heal slower than small ones (rat, mouse). Miura et al 40 showed... infarction in rats. J Mol Cell Cardiol 1997, ... Source: Murry, Chuck - Center for Cardiovascular Biology...

92

E-Print Network 3.0 - adult rat hepatocytes Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

sources Hepatocytes. Hepatocytes were isolated from 180-g to 220-g Sprague Dawley male rats using... . SUMMARY Micropatterned hepatocytes co-cultured with rat KCs, fibroblasts, or...

93

E-Print Network 3.0 - adult rat liver Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

from normal rat liver and incubated for 3 or 16 hours with increasing doses... of carbon tetrachloride (CCl4). Rat ... Source: Groningen, Rijksuniversiteit - Centre for...

94

Structures of the rat complement regulator CrrY  

Science Journals Connector (OSTI)

The structure of rat CrrY1-4 determined in two distinct crystal forms shows a pronounced bend at the interface between domains 3 and 4.

Roversi, P.

2011-06-23T23:59:59.000Z

95

Uranium biokinetics in gavaged young adult female rats.  

E-Print Network [OSTI]

??Blood, liver, kidney, femur, and ovaries were assayed from female Wistar rats following oral administration of uranyl nitrate. Three uranium concentrations were studied for six (more)

Keizer, Philip John

1986-01-01T23:59:59.000Z

96

Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo  

SciTech Connect (OSTI)

Human response to isoproterenol induced cardiac injury was evaluated by gene and protein pathway changes in human heart slices, and compared to rat heart slices and rat heart in vivo. Isoproterenol (10 and 100 ?M) altered human and rat heart slice markers of oxidative stress (ATP and GSH) at 24 h. In this in vivo rat study (0.5 mg/kg), serum troponin concentrations increased with lesion severity, minimal to mild necrosis at 24 and 48 h. In the rat and the human heart, isoproterenol altered pathways for apoptosis/necrosis, stress/energy, inflammation, and remodeling/fibrosis. The rat and human heart slices were in an apoptotic phase, while the in vivo rat heart exhibited necrosis histologically and further progression of tissue remodeling. In human heart slices genes for several heat shock 70 kD members were altered, indicative of stress to mitigate apoptosis. The stress response included alterations in energy utilization, fatty acid processing, and the up-regulation of inducible nitric oxide synthase, a marker of increased oxidative stress in both species. Inflammation markers linked with remodeling included IL-1?, Il-1?, IL-6 and TNF? in both species. Tissue remodeling changes in both species included increases in the TIMP proteins, inhibitors of matrix degradation, the gene/protein of IL-4 linked with cardiac fibrosis, and the gene Ccl7 a chemokine that induces collagen synthesis, and Reg3b a growth factor for cardiac repair. This study demonstrates that the initial human heart slice response to isoproterenol cardiac injury results in apoptosis, stress/energy status, inflammation and tissue remodeling at concentrations similar to that in rat heart slices. - Highlights: Human response to isoproterenol induced cardiac injury evaluated in heart slices. Isoproterenol altered apoptosis, energy, inflammation and remodeling pathways. Human model verified by comparison to rat heart slices and rat heart in vivo. Human and rat respond to isoproterenol at similar concentrations in vitro.

Herrmann, Julia E.; Heale, Jason; Bieraugel, Mike; Ramos, Meg [Drug Safety Evaluation, Allergan Inc., 2525 Dupont Dr, Irvine, CA 92612 (United States); Fisher, Robyn L. [Vitron Inc., Tucson, AZ (United States); Vickers, Alison E.M., E-mail: vickers_alison@allergan.com [Drug Safety Evaluation, Allergan Inc., 2525 Dupont Dr, Irvine, CA 92612 (United States)

2014-01-15T23:59:59.000Z

97

Interaction of Tomato Lycopene and Ketosamine against Rat Prostate Tumorigenesis  

Science Journals Connector (OSTI)

...with 12 h light: 12 h dark cycle. The animals were...necropsied immediately on discovery. Rats that were going...ad libitum maintenance energy consumption level for...Wistar-Unilever rats receiving energy-balanced experimental...powder, lycopene, or energy-restricted diets...

Valeri V. Mossine; Pankaj Chopra; and Thomas P. Mawhinney

2008-06-01T23:59:59.000Z

98

Lymphatic Pathways from the Tail in Rats and Mice  

Science Journals Connector (OSTI)

...from the Tail in Rats and Mice Arnfinn Engeset * Enok Tjotta ( Norsk Hydro's Institute for Cancer Research, Norwegian Radium Hospital...from the Tail in Rats and Mice ARNFINNENGESET*ANDENOKTJ TTA (Norsk Hydro's Institute for Cancer Research, Norwegian Radium Hospital...

Arnfinn Engeset and Enok Tjtta

1960-06-01T23:59:59.000Z

99

Acceleration of wound healing in young and aged rats  

E-Print Network [OSTI]

Wound healing in the aged is delayed. A 6 mm punch biopsy wound heals in 13 days in a 3 month old rat, but takes 21 days to heal in a 2 year old rat. It is our belief that this impairment in healing may be due in part to a macrophage defect present...

Maxwell, Bryan Douglas

2012-06-07T23:59:59.000Z

100

REINFORCEMENT LEARNING APPROACHES TO INSTRUMENTAL CONTINGENCY DEGRADATION IN RATS  

E-Print Network [OSTI]

REINFORCEMENT LEARNING APPROACHES TO INSTRUMENTAL CONTINGENCY DEGRADATION IN RATS Alain Dutech1 of the consequences of an action. Rats with lesions of the medial prefrontal cortex do not adapt their instrumental response in a Skinner box when food delivery becomes unrelated to lever pressing. This indicates a role

Boyer, Edmond

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Inconclusive Experiment with Rats By Bill Menke, December 1, 2013  

E-Print Network [OSTI]

Inconclusive Experiment with Rats By Bill Menke, December 1, 2013 The New York Times recently of genetically-modified corn. The Times article says: The editor of the journal, Food and Chemical Toxicology the paper's main result, that rats fed genetically-modified, herbicide-resistant corn have a higher incident

Menke, William

102

Modeling Interactions of the Rat's Place and Head Direction Systems  

E-Print Network [OSTI]

Modeling Interactions of the Rat's Place and Head Direction Systems A. David Redish and David S in a set of experiments by Sharp et al. (1990). 1 The Sharp et al., 1990 experiment Rats spent multiple sessions finding food scattered randomly on the floor of a black cylin­ drical arena with a white cue card

Touretzky, David S.

103

The Norway rat4 Bennett G. Galef6  

E-Print Network [OSTI]

1 1 2 3 The Norway rat4 5 Bennett G. Galef6 7 8 9 Department of Psychology, development, domestication, food choice,31 learning, olfaction, reproduction, social learning, taste of smell.48 49 Synopsis50 #12;3 Norway rats served for many decades as the main subject species

Galef Jr., Bennett G.

104

A DELAYED NONLINEAR PBPK MODEL FOR GENISTEIN DOSIMETRY IN RATS  

E-Print Network [OSTI]

A DELAYED NONLINEAR PBPK MODEL FOR GENISTEIN DOSIMETRY IN RATS #3; MICHAEL G. ZAGER y , HIEN T endocrine-related e#11;ects such as reduced birth weight in rats and humans. In its conjugated form], including soybean-derived foods with high genistein concentrations, such as tofu and soy-derived infant

105

Averaging of Temporal Memories by Rats Dale N. Swanton  

E-Print Network [OSTI]

Averaging of Temporal Memories by Rats Dale N. Swanton Villanova University Cynthia M. Gooch University of Pennsylvania School of Medicine Matthew S. Matell Villanova University Rats were trained on a mixed fixed-interval schedule in which stimulus A (tone or light) indicated food availability after 10

Matell, Matthew S.

106

Lithium treatment reduces morphine self-administration in addict rats  

Science Journals Connector (OSTI)

... Lithium also has been shown to interact with morphine: it can sometimes reduce morphine-induced ... mice7'8 and potentiate morphine analgesia in rats9. We have therefore investigated the possibility that lithium may affect the amount of voluntary ingestion of morphine by addict rats.

MICHAL TOMKIEWICZ; HANNAH STEINBERG

1974-11-15T23:59:59.000Z

107

The Energy Expenditure of Rats Bearing Walker Carcinoma 256  

Science Journals Connector (OSTI)

...the law of conservation of energy holds true for the animal body...010 0.010 0.100 731 The Energy Expenditure of Rats Bearing...product which is difficult to mix. Samples to be burned were...nitro.. Mmir@iiet al. "Energy Expenditure of Tumorous Rats...

G. B. Mider; L. D. Fenninger; F. L. Haven; and J. J. Morton

1951-09-01T23:59:59.000Z

108

Ethylene Production by Subcellular Particles from Rat Liver, Rat Intestinal Mucosa and Penicillium Digitatum  

Science Journals Connector (OSTI)

... been reported that all fruits, without exception, give off ethylene1. While the production of ethylene by fruits and certain micro-organisms has been the subject of extensive investigation over the ... virtually ignored. Recently, Kakanov2 provided evidence that both normal rats and pig ascarids produce ethylene. Although no attempt was made to remove ...

G. RAM CHANDRA; MARY SPENCER

1963-01-26T23:59:59.000Z

109

! !-q ~ i,. Altered Peripheral and Brainstem Auditory Function in Aged Rats  

E-Print Network [OSTI]

-related hearing lossin rats. INTRODUC~IION Behavioral and anatomical studies indicate that the decreased auditory

Knight, Robert T.

110

THE EFFECTS OF HANDLING ON EPISODIC RELEASE OF LH IN IMMATURE RATS  

E-Print Network [OSTI]

THE EFFECTS OF HANDLING ON EPISODIC RELEASE OF LH IN IMMATURE RATS Pamela C. B. MacKINNON Jeannine development immature female rats between 4-30 days of age and male rats from 6 days of age to adulthood rats, which were killed by decapitation, had serum levels > 7.o ng NIH- LH-SI3/ml (MATTOCK and Mac

Paris-Sud XI, Université de

111

The Roles of Accumbal Dopamine D1 and D2 Receptors in Maternal Memory in Rats  

E-Print Network [OSTI]

The Roles of Accumbal Dopamine D1 and D2 Receptors in Maternal Memory in Rats Mayte Parada of Toronto Female rats show enhanced maternal responsiveness toward their young if they have had maternal-Z-flupenthixol, into the NA shell of postpartum female rats. Sulpiride-infused rats showed a significantly longer latency

Sokolowski, Marla

112

initial rise in respiratory quotient (RQ) was also similar in both groups. However, in rats  

E-Print Network [OSTI]

initial rise in respiratory quotient (RQ) was also similar in both groups. However, in rats fed in rats fed the TC diet the decline in RQ was more progressive and began its decrease only 3-4 h after ad libitum to two groups of eight male Wister rats. Rats fed the TD diet showed the first significant

Paris-Sud XI, Université de

113

Available online at www.sciencedirect.com `Conformity' in Norway rats?  

E-Print Network [OSTI]

with `demonstrator' rats that have eaten that food. Such observer rats will eat as much unpalatable or presumably toxic food after interacting with demonstrator rats that have eaten them as they would if they hadAvailable online at www.sciencedirect.com `Conformity' in Norway rats? BENNETT G. GALEF & ELAIN E

Galef Jr., Bennett G.

114

Comparison of sex-steroid synthesis between neonatal and adult rat hippocampus  

E-Print Network [OSTI]

Comparison of sex-steroid synthesis between neonatal and adult rat hippocampus Shimpei Higo a,1-steroid metabolism in male rat hippo- campus between postnatal 10-day old (P10) and young adult stages. We also 10-day male Wistar rats (P10) and young adult rats (12 weeks old) were purchased from Saitama Experi

Kawato, Suguru

115

Urinary metabolites of busulfan in the rat  

SciTech Connect (OSTI)

After ip administration of 15 mg/kg (1,4-/sup 14/C)busulfan to rats, the urinary excretion was 70% of the total radioactivity after 72 hr. Three major metabolites were isolated and quantified by HPLC. Of the total radioactivity in the urine, unchanged busulfan was excreted as a minor amount (6%) and the following metabolites were identified as: 3-hydroxysulfolane (39%), tetrahydrothiophene 1-oxide (20%), and sulfolane (13%) using GC/MS and NMR spectroscopy. The cytotoxicity of busulfan and its major metabolites was examined using a V79 Chinese hamster cell line.

Hassan, M.; Ehrsson, H.

1987-05-01T23:59:59.000Z

116

Ultrastructural development of the rat corpus luteum  

E-Print Network [OSTI]

hitehoiise q r ~ T stiiy y of tne ultr structu. "e of the d. velopin' corpus lu eum cells;ias carried out. The rats::ere sacrificed according to their st-, -. e of estrous, eiid their ovaries removed immediately before dicath. The tissue was fixed in 25... glutaraldehyde which was buffered i;ith s-collidine, and was post fixed i? osmium tetroxide. Embedding was in i'araglas. Both pre and postovulatory tissue were studied. with the electron microscope, and cell types observed in each of' the two tissues...

Bailey, John Franklin

2012-06-07T23:59:59.000Z

117

The Effects of Aging on Spatial Memory Reconsolidation in Rats B. Jones , E. Bukoski , L. Nadel , JM. Fellous  

E-Print Network [OSTI]

rats which were mildly food deprived. Y Y Pretraining List Training: rats learn a list of 3 feeders (eThe Effects of Aging on Spatial Memory Reconsolidation in Rats 1 2 2 2,3 B. Jones , E. Bukoski , L in young rats but not in aged rats 1. Introduction £ £ £ £ £ Memory reconsolidation is the process by which

Fellous, Jean-Marc

118

The neurological effects of brevetoxin on neonatal rats  

SciTech Connect (OSTI)

We have investigated the neuroexcitatory and neurodegenerative effects of brevetoxin on neonatal rats. Brevetoxin, a marine-biotoxin that has been implicated in several seafood poisoning incidents, is produced by the dinoflagellate Gymnodinium brevis. Four studies were done: dose response, northern analysis, immunohistochemistry and neurodegeneration. We found that neonatal rats are much more sensitive to brevetoxin than adult rats. The effectiveness of c-fos as a biomarker is being investigated, because of the high basal expression in young animals. The neurodegeneration, although not available yet, should provide valuable information.

Tapley, S.R.; Ramsdell, J.S.; Xi, D. [Medical Univ. of South Carolina, Charleston, SC (United States)] [and others

1994-12-31T23:59:59.000Z

119

Eusociality in African mole-rats: new insights from patterns of genetic relatedness in the Damaraland mole-rat (Cryptomys damarensis)  

Science Journals Connector (OSTI)

...research-article Eusociality in African mole-rats: new insights from patterns of genetic relatedness in the Damaraland mole-rat (Cryptomys damarensis) Tamsin M. Burland...discovery of eusociality in the naked mole-rat, it was proposed that inbreeding and high...

2002-01-01T23:59:59.000Z

120

Guide to A Successful Rat's Mouth Tailgate This guide was developed to assist student organizations in the Organized Student Tailgate Area (Rat's Mouth).  

E-Print Network [OSTI]

9/28/2011 Guide to A Successful Rat's Mouth Tailgate This guide was developed to assist student organizations in the Organized Student Tailgate Area (Rat's Mouth). Please note there will be FAU staff present, student organizations will be assigned to a space in the Rat's Mouth. You may not set-up on or cook on any

Fernandez, Eduardo

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

AMPA-receptor mediated plasticity within the rat spinal cord  

E-Print Network [OSTI]

Previous research from our laboratory has demonstrated that the spinal cord is capable of a simple form of instrumental learning. In this instrumental learning paradigm, rats typically receive a complete spinal transection at the second thoracic...

Hoy, Kevin Corcoran

2009-05-15T23:59:59.000Z

122

Metabolic properties in stroked rats revealed by relaxation-enhanced...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

metabolic properties via 1 H MRS at ultra-high fields. Metabolic properties in stroked rats revealed by relaxation-enhanced MR spectroscopy at 21.1 T Noam Shemesh 1 , Jens T...

123

Preexposure sensitizes rats to the reinforcing effects of cocaine  

E-Print Network [OSTI]

PREEXPOSURE SENSITIZES RATS TO THE REINFORCING EFFECTS OF COCAINE A Thesis by BRIAN ARTHUR HORGER Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE May 1990 Major Subject: Psychology PREEXPOSURE SENSITIZES RATS TO THE REINFORCING EFFECTS OF COCAINE A Thesis by BRIAN ARTHUR HORGER Approved as to style and content by: Susan Sch nk ' (Chair of Committee) ~, r, :. ). ~+~~- ?- : Jack R...

Horger, Brian Arthur

2012-06-07T23:59:59.000Z

124

Non-essential amino acid metabolism in rats  

E-Print Network [OSTI]

NON-ESSENTIAL AMINO ACID METABOLISM IN RATS A Thesis by JAMES DARRELL CROOKS, JR. Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement for the degree of MASTER OF SCIENCE May 1971 Major Subject...: Animal Nutrition O 4 0 E ? NON ESSENTIAL AMINO ACID METABOLISM IN RATS A Thesis by JAMES DARRELL CROOKS& JR. Approved as to style and content by: (Chairman of Committee) (Member) (Head of Department) (Member) May 197 1 ABSTRACT Non...

Crooks, James Darrell

2012-06-07T23:59:59.000Z

125

Intracellular protein degradation in cultured rat muscle cells  

E-Print Network [OSTI]

1982 Major Subject: Biochemistry INTRACELLULAR PROTEIN DEGRADATION IN CULTURED RAT MUSCLE CELLS A Thesis by GWENDOLYN BETH MILLER Approved as to style and content by: hairman of Committee) p I 'P) (Member) (M r) (Head of Department) August... 1982 "BOGS-'. 4( 3 3q ABSTRACT Intracellular Protein Degradation in Cultured Rat Muscle Cells (August 1982) Gwendolyn Beth Miller, B. S. , Texas Asm Dniversity Chairman of Advisory Committee: Dr. J. martyn Gunn Intra:elMlar protein degradation...

Miller, Gwendolyn Beth

1982-01-01T23:59:59.000Z

126

Susceptibility of immature rats to seizures induced by unsymmetrical dimethylhydrazine  

E-Print Network [OSTI]

SUSCEPTIBILITY OF IMMATURE RATS TO SEIZURES INDUCED BY UNSYMMETRICAL DIMETHYLHYDRAZINE A Thesis By DALE DUAINE BOYD Submitted to the Graduate School of the Agricultural and Mechanical College of Texas in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE August 1963 Major Subject: Laboratory Animal Medicine SUSCEPTIBILITY Of IMMATURE RATS TO SEIZURES INDUCED BY UNSYMMETRICAL DIMETHYLHYDRAZINE A Thesis By DALE DUAINE BOYD Approved as to style and content...

Boyd, Dale Duaine

2012-06-07T23:59:59.000Z

127

The effect of fear on gregariousness and exploration in rats  

E-Print Network [OSTI]

THE EFFECT OF FEAR ON GREGARIOUSNESS AND EXPLORATION IN RATS A Thesis by BERGIE WAYNE ANDERSON Submitted to the Graduate College of Texas A & N University in partial fulfillment of the requirement for the degree of MASTER OF SCIENCE August... 1973 Major Subject: Psychology THE EFFECT OF FEAR ON GREGARIOUSNESS AND EXPLORATION IN RATS A Thesis by BERGIE WAYNE ANDERSON Approved as to style and content by: / / (Chairman of Co 'ttee) ( ( )&ember ) (I(cad of D artment) ( Hember...

Anderson, Bergie Wayne

2012-06-07T23:59:59.000Z

128

Toxicologic and biochemical effects of extracts from Karwinskia humboldtiana on the albino rat  

E-Print Network [OSTI]

) received empty gelatin capsules once each week for seven weeks. Group IV-C contained six control rats, and these rats were not fed Ch-3. The treated rats in Group IV-A and the control rats in Group IV-C were fed Purina Rat Chow ad libitum throughout... the study. The treated animals in Group IV-A were individually killed by decapitation and necropsied when it appeared they were in a moribund condition. Rats in Groups IV-B and IV-C were killed and necropsied on the BBth day. Blood samples were collected...

Wheeler, Michael Hugh

1970-01-01T23:59:59.000Z

129

Comparison of amitriptyline metabolism in hepatocytes from streptozocin-induced diabetic rats and from non-diabetic rats  

Science Journals Connector (OSTI)

Biotransformation of amitriptyline (AMI) was studied at different intervals in freshly isolated hepatocytes from healthy or streptozocin-induced diabetic rats in order to investigate the influence of ... HPLC ana...

F. Coudor; A. Besson; R. Shrivastava; A. Chevalier

1997-02-01T23:59:59.000Z

130

Historical Mammal Extinction on Christmas Island (Indian Ocean) Correlates with Introduced Infectious Disease  

E-Print Network [OSTI]

Historical Mammal Extinction on Christmas Island (Indian Ocean) Correlates with Introduced. A case in point is the extinction of the endemic Christmas Island rat (Rattus macleari): although it has on Christmas Island (Indian Ocean) Correlates with Introduced Infectious Disease. PLoS ONE 3(11): e3602. doi:10

DeSalle, Rob

131

Blood-ethanol levels predict amount of ethanol consumption by rats  

Science Journals Connector (OSTI)

A previous report that low-drinker rats develop higher peak blood-ethanol levels than high-drinker rats following intraperitoneal ethanol is confirmed. Further, a strong correlation occurred between blood-ethanol

Steven Belenko; Stephen C. Woods

1975-12-01T23:59:59.000Z

132

E-Print Network 3.0 - adult cotton rats Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

cotton rats Search Powered by Explorit Topic List Advanced Search Sample search results for: adult cotton rats Page: << < 1 2 3 4 5 > >> 1 BioOne sees sustainable scholarly...

133

Mineral utilization of malted sorghum and corn with added crayfish in rats  

Science Journals Connector (OSTI)

Forty adult rats were used to study the mineral balances of malted and unmalted wet- or dry-milled sorghum and corn combined with crayfish and fed rats for ... for the entire study period. Malting and wet milling

Ikemefuna C. Obizoba

1989-06-01T23:59:59.000Z

134

E-Print Network 3.0 - aging pregnant rats Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

native forest, regardless of logging history, than in exotic forest of any age. Young ship rats (age... set near a permanent colony. Pregnant female Nor- way rats were trapped in...

135

E-Print Network 3.0 - adult rat central Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

136

E-Print Network 3.0 - adult rats exposed Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

137

E-Print Network 3.0 - adult rat offspring Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

138

E-Print Network 3.0 - adult rats tested Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

139

E-Print Network 3.0 - adult rats potential Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

140

E-Print Network 3.0 - adult rats relationship Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

E-Print Network 3.0 - adult rats efeito Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

142

E-Print Network 3.0 - adult rats treated Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

143

E-Print Network 3.0 - adult rats fed Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

144

Percutaneous penetration of uranium in rats after a contamination on intact or wounded skin  

Science Journals Connector (OSTI)

......Hoover M. D. Implanted depleted uranium fragments cause soft...muscles of rats. Environ. Health Perspect (2002) 110...Biokinetics and dosimetry of depleted uranium (DU) in rats implanted...international conference on Health Effects of Incorporated......

F. Petitot; C. Gautier; A. M. Moreels; S. Frelon; F. Paquet

2007-11-01T23:59:59.000Z

145

Accumulation and Distribution of Uranium in Rats after Implantation with Depleted Uranium Fragments  

Science Journals Connector (OSTI)

......Rats after Implantation with Depleted Uranium Fragments Guoying Zhu 1 * Mingguang...and distribution of uranium in depleted uranium (DU) implanted rats. Materials...of chronic exposure to DU. Depleted uranium|Bone|Kidney|Distribution......

Guoying Zhu; Mingguang Tan; Yulan Li; Xiqiao Xiang; Heping Hu; Shuquan Zhao

2009-05-01T23:59:59.000Z

146

The Reproductive Effects in Rats after Chronic Oral Exposure to Low-dose Depleted Uranium  

Science Journals Connector (OSTI)

......Oral Exposure to Low-dose Depleted Uranium Yuhui Hao Rong Li * Yanbing...study evaluated the effects of depleted uranium (DU) on reproduction in rats...effects were obvious in F1 rats. Depleted uranium|Ingestion|Reproductive effects......

Yuhui Hao; Rong Li; Yanbing Leng; Jiong Ren; Jing Liu; Guoping Ai; Hui Xu; Yongping Su; Tianmin Cheng

2012-05-01T23:59:59.000Z

147

E-Print Network 3.0 - alpha-chlorohydrin-induced infertile rats...  

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chlorohydrin-induced infertile rats Search Powered by Explorit Topic List Advanced Search Sample search results for: alpha-chlorohydrin-induced infertile rats Page: << < 1 2 3 4 5...

148

E-Print Network 3.0 - anesthetized spinal rats Sample Search...  

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spinal rats Search Powered by Explorit Topic List Advanced Search Sample search results for: anesthetized spinal rats Page: << < 1 2 3 4 5 > >> 1 JOURNAL OF NEUROTRAUMA Volume 19,...

149

E-Print Network 3.0 - age-increasing offspring rats Sample Search...  

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increasing offspring rats Search Powered by Explorit Topic List Advanced Search Sample search results for: age-increasing offspring rats Page: << < 1 2 3 4 5 > >> 1 Epigenetics and...

150

E-Print Network 3.0 - adolescent male rats Sample Search Results  

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male rats Search Powered by Explorit Topic List Advanced Search Sample search results for: adolescent male rats Page: << < 1 2 3 4 5 > >> 1 Back to the future: The...

151

E-Print Network 3.0 - alloxan-induced diabetic rats Sample Search...  

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rats Search Powered by Explorit Topic List Advanced Search Sample search results for: alloxan-induced diabetic rats Page: << < 1 2 3 4 5 > >> 1 Localization of Na,K-ATPase ...

152

E-Print Network 3.0 - anesthetized female rats Sample Search...  

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female rats Search Powered by Explorit Topic List Advanced Search Sample search results for: anesthetized female rats Page: << < 1 2 3 4 5 > >> 1 08102005 09:50 AMCH 2000(4) Page...

153

E-Print Network 3.0 - adult rat ventricular Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ventricular Page: << < 1 2 3 4 5 > >> 1 CONTRAST AGENT-INDUCED CARDIAC ARRHYTHMIAS IN RATS James F. Zachary Summary: each rat was exposed for a second time to pulsed ultrasound...

154

E-Print Network 3.0 - alloxan diabetic rats Sample Search Results  

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diabetic rats Search Powered by Explorit Topic List Advanced Search Sample search results for: alloxan diabetic rats Page: << < 1 2 3 4 5 > >> 1 Glucokinase Is the Likely Mediator...

155

E-Print Network 3.0 - african mole rats Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

mole rats Search Powered by Explorit Topic List Advanced Search Sample search results for: african mole rats Page: << < 1 2 3 4 5 > >> 1 MAMMALIAN SPECIES No. 756, pp. 15, 3 figs....

156

E-Print Network 3.0 - adult rat pancreas Sample Search Results  

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-expressing vector as 5 doses between 27 and 39 h after the first dose of HGF into young adult rats (data not shown... , Thyroid, Spleen, and Colon in Rats in Vivo Cuihua ......

157

Methods For Simultaneous Optical And Electrical Measurement Of Neurovascular Coupling in Awake Rats  

Science Journals Connector (OSTI)

Development of an implantable EEG and diffuse optical imaging probe for longitudinal measurements in awake rats to investigate neurovascular coupling.

Sutin, Jason; Wu, Weicheng; Ruvinskaya, Lana; Franceschini, Maria Angela

158

E-Print Network 3.0 - aging female rats Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

DAMAGE POTENTIAL OF THREE RODENT SPECIES ON Summary: : 0.39 0.03g; female cotton rats: 0.34 0.03g; male roof rats:0.25 0.04g; female roof rats:0... .26 0.04g;...

159

Serum proteins in magnesium-deficient rat Y. RAYSSIGUIER P. LARVOR Y. AUGUSTI J. DURLACH  

E-Print Network [OSTI]

Serum proteins in magnesium-deficient rat Y. RAYSSIGUIER P. LARVOR Y. AUGUSTI J. DURLACH (1 Cochin, Paris Summary. Hypoproteinemia appears early in the magnesium-deficient rat with a drop in serum. In the magnesium-deficient rat, we have shown serum protein modifications related to immunologic and allergic

Paris-Sud XI, Université de

160

Amygdaloid and non-amygdaloid fear both influence avoidance of risky foraging in hungry rats  

Science Journals Connector (OSTI)

...influence avoidance of risky foraging in hungry rats Earnest Kim 1 Eun Joo Kim 1 Regina Yeh...therefore of interest that we have found in rats living for extended periods in a semi-naturalistic...semi-naturalistic closed economy in which rats lived for extended periods [17,18...

2014-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
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to obtain the most current and comprehensive results.


161

CHANGES IN OVARIAN FUNCTION ASSOCIATED WITH OXYTOCIN INJECTION TO IMMATURE RATS  

E-Print Network [OSTI]

CHANGES IN OVARIAN FUNCTION ASSOCIATED WITH OXYTOCIN INJECTION TO IMMATURE RATS AL-JANABI AS YOUSIF) in heifers and castrated adult male rats. With respect to ovarian function, several investigators (Arm: 50 (a) or 250 (b) mp per day per animal. 1. Experimental groups group 1: rats treated with oxytocin

Paris-Sud XI, Université de

162

Ecological constraints drive social evolution in the African molerats  

Science Journals Connector (OSTI)

...social evolution in the African mole-rats C. G. Faulkes 1 * N. C. Bennett 2 M...Town, South Africa The African mole-rats (family Bathyergidae) are subterranean...to the social species. The naked mole-rat (Heterocephalus glaber) is ancestral...

1997-01-01T23:59:59.000Z

163

JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR INCREASED EATING IN RATS DEPRIVED OF RUNNING'  

E-Print Network [OSTI]

JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR INCREASED EATING IN RATS DEPRIVED OF RUNNING' DAVID PREMACK2 AND ANNE J. PREMACK UNIVERSITY OF MISSOURI Daily food intake in rats was temporarily the rat is deprived of a behavior that recurrently comprises a large part of its total daily actiyity

Premack, David

164

The effects of adrenalectomy and corticosterone replacement on maternal memory in postpartum rats  

E-Print Network [OSTI]

The effects of adrenalectomy and corticosterone replacement on maternal memory in postpartum rats M prime rats to behave maternally, although hormonal changes are not necessary for these behaviors with corticosterone or vehicle pellets being given to adrenalectomized rats. Pups were removed immediately following

Sokolowski, Marla

165

Soluble epoxide hydrolase inhibitor, t-TUCB, protects against myocardial ischaemic injury in rats  

E-Print Network [OSTI]

Soluble epoxide hydrolase inhibitor, t-TUCB, protects against myocardial ischaemic injury in rats in male Wistar rats. Cardioprotection was assessed by measuring elecrocardiographic (EKG), serum lactate-induced myo- cardial ischaemic injury in rats. This study provides a preliminary confirmation of the efficacy

Hammock, Bruce D.

166

Polymorphism in Soluble Epoxide Hydrolase and Blood Pressure in Spontaneously Hypertensive Rats  

E-Print Network [OSTI]

Polymorphism in Soluble Epoxide Hydrolase and Blood Pressure in Spontaneously Hypertensive Rats in prehypertensive (4 to 5 weeks old) spontaneously hypertensive rats of the Heidelberg SP substrain (SHR [Heid expression with matched Wistar-Kyoto (WKY [Heid]) rats. Less expression of the gene encoding sEH (EPHX2

Hammock, Bruce D.

167

Simulated shift work in rats perturbs multiscale regulation of locomotor activity  

Science Journals Connector (OSTI)

...articles 1004 16 30 22 Simulated shift work in rats perturbs multiscale regulation of locomotor...hypothesis, we studied activity fluctuations of rats in a simulated shift work protocol that...fractal activity patterns in SCN-lesioned rats [7] and in elderly humans with AD and...

2014-01-01T23:59:59.000Z

168

Analysis of the connectional organization of neural systems associated with the hippocampus in rats  

Science Journals Connector (OSTI)

...systems associated with the hippocampus in rats Gully A. P. C. Burns Malcolm P. Young...uponTyne NE1 7RU, UK The hippocampus of the rat enjoys a central significance for researchers...connectivity of the hippocampal system in the rat, and analysed the resulting data. Analyses...

2000-01-01T23:59:59.000Z

169

Training rats to search and alert on contraband odors James Ottoa,*  

E-Print Network [OSTI]

Training rats to search and alert on contraband odors James Ottoa,* , Michael F. Brownb , William experiments that were conducted to test a new concept using rats to detect contraband odors, such as explosives, drugs, or prohibited foodstuffs. Under this concept, the trained alerting behavior of rats

Cook, Robert

170

Differential regulation of muscle and liver insulin receptors by energy restriction in growing rats  

E-Print Network [OSTI]

Differential regulation of muscle and liver insulin receptors by energy restriction in growing rats and liver in growing rats undergoing an energy restriction. The influence of plasma insulin was investigated. Animals and treatments. ― Male Sprague Dawley rats, housed in individual cages under controlled

Paris-Sud XI, Université de

171

Water balance in rats exposed to chronic centrifugation RUDY M. ORTIZ AND CHARLES E. WADE  

E-Print Network [OSTI]

Water balance in rats exposed to chronic centrifugation RUDY M. ORTIZ AND CHARLES E. WADE Life; accepted in final form 22 February 2000 Ortiz, Rudy M., and Charles E. Wade. Water balance in rats exposed was conducted to determine the effects of chronic centrifugation on water bal- ance. Eight Sprague-Dawley rats

Ortiz, Rudy M.

172

PARADOXICAL ROLE OF ANGIOTENSIN II TYPE 2 RECEPTORS IN RESISTANCE ARTERIES OF OLD RATS.  

E-Print Network [OSTI]

PARADOXICAL ROLE OF ANGIOTENSIN II TYPE 2 RECEPTORS IN RESISTANCE ARTERIES OF OLD RATS. #Frederic vasodilatory and antitrophic properties are well accepted. Nevertheless, in hypertensive rats AT2R stimulation hypothesized that AT2R function might be altered in old rats resistance arteries. Mesenteric resistance

Paris-Sud XI, Université de

173

Early Adversity Alters Attention and Locomotion in Adult SpragueDawley Rats  

E-Print Network [OSTI]

Early Adversity Alters Attention and Locomotion in Adult Sprague�Dawley Rats Christie Burton the effects of prenatal stress and its interaction with artificial rearing (AR) on adult rat behavior by their mothers or in the AR paradigm, with or without stroking stimulation. In adulthood, rats were tested

Sokolowski, Marla

174

The effects of early rearing environment on the hormonal induction of maternal behavior in virgin rats  

E-Print Network [OSTI]

rats Marko Novakov, Alison S. Fleming* Psychology Department, University of Toronto at Mississauaga rearing paradigm (AR), on the hormonal induction of maternal behavior (MB) in female Sprague�Dawley rats. Between postnatal days (PND) 4 and 18, rat pups were raised either with their mothers (MR) or artificially

Sokolowski, Marla

175

Is alpha-Pinene a Substrate for Permeability-Glycoprotein in Wood Rats?  

E-Print Network [OSTI]

Is alpha-Pinene a Substrate for Permeability- Glycoprotein in Wood Rats? Adam K. Green & Shannon L Media, Inc. 2006 Abstract alpha-Pinene is the dominant monoterpene in Juniperus monosperma. Wood rat generalist, and Sprague-Dawley rats, and (2) in Caco-2 cells that over express Pgp. We also measured Pgp

Mladenoff, David

176

Could rats really grow as big as sheep?1 By Katy Marriott2  

E-Print Network [OSTI]

Could rats really grow as big as sheep?1 By Katy Marriott2 3 You've been following the news this week, you may have heard that sheep-sized rats will soon be rampaging through our4 towns and cities. Yes, that's right. Rats. As big as sheep.5 6 Or at least, that's what some of the papers would have

South Bohemia, University of

177

Motorsensory convergence in object localization: a comparative study in rats and humans  

Science Journals Connector (OSTI)

...object localization: a comparative study in rats and humans Guy Horev 1 2 Avraham Saig 1...process of tactile perception, we trained rats and humans in similar object localization...used by the two species. We found that rats integrated temporally related sensory inputs...

2011-01-01T23:59:59.000Z

178

Promotion of Endodontic Lesions in Rats by a Novel Extraradicular Biofilm Model Using Obturation Materials  

Science Journals Connector (OSTI)

...Microbiology Promotion of Endodontic Lesions in Rats by a Novel Extraradicular Biofilm Model...in vivo extraradicular biofilm model in rats and to identify and quantify extraradicular...mandibular first molars of male Wistar rats to their oral environment. Four weeks...

Katsutaka Kuremoto; Yuichiro Noiri; Takuya Ishimoto; Naomichi Yoneda; Reiko Yamamoto; Hazuki Maezono; Takayoshi Nakano; Mikako Hayashi; Shigeyuki Ebisu

2014-04-18T23:59:59.000Z

179

A UA study shows how an active marihuana ingredient preserves vision in rats with retinosis pigmentosa  

E-Print Network [OSTI]

A UA study shows how an active marihuana ingredient preserves vision in rats with retinosis strong vision-preserving effects in rats with a form of autosomal dominant retinitis pigmentosa, administered in rats suffering from this disease, had 40 percent more rows of photoreceptors and 70 percent

Escolano, Francisco

180

Mammalian microevolution in action: adaptive edaphic genomic divergence in blind subterranean molerats  

Science Journals Connector (OSTI)

...divergence in blind subterranean mole-rats Andrei Polyakov 1 2 Alex Beharav 1 Aaron...examined in 20 individuals of the blind mole-rat, Spalax galili, one of four allospecies...superspecies of blind subterranean mole-rats in Israel. We compared 10 individuals...

2004-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Dietary fiber and cholesterol and bile acid metabolism in axenic (germfree) and holoxenic (conventional) rats. III.  

E-Print Network [OSTI]

(conventional) rats. III. Effect of non-sterilized pectin E. SACQUET, C. LEPRINCE, M. RIOTTOT P. RAIBAUD-en-Josas, France. Summary. Axenic (germfree) and holoxenic (conventional) rats were given a pectin- containing diet and large intestine of both germfree and conventional rats. Pectin decreased the absorption coefficient

Paris-Sud XI, Université de

182

Thyroid hormone regulates Na+ currents in cultured hippocampal neurons from postnatal rats  

Science Journals Connector (OSTI)

...cultured hippocampal neurons from postnatal rats O. Potthoff I. D. Dietzel * * To whom...currents in hippocampal neurons from newborn rats. Thus, the well known effects of thyroid...cultured hippocampal neurons from postnatal rats. | The causes for mental retardation due...

1997-01-01T23:59:59.000Z

183

A simple system for nutritional studies with chronic consumption of liquid diet in rats  

E-Print Network [OSTI]

Short note A simple system for nutritional studies with chronic consumption of liquid diet in rats to rats without any loss by evapora- tion is described. A liquid diet stirred continuously is offered to rats in water bottles. The diet is made available to the animals without any clotting throughout the 24

Paris-Sud XI, Université de

184

Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats  

E-Print Network [OSTI]

rats Kathleen Guglielmino,1 Kaleena Jackson,1 Todd R. Harris,2 Vincent Vu,3 Hua Dong,2 Gavin Dutrow,3 provides cardioprotection in hypergly- cemic rats. Am J Physiol Heart Circ Physiol 303: H853­H862, 2012 cardiac myocyte struc- ture and function in hyperglycemic rats. University of California- Davis-type 2

Hammock, Bruce D.

185

DRD2 Gene Transfer Into the Nucleus Accumbens Core of the Alcohol Preferring and Nonpreferring Rats  

E-Print Network [OSTI]

DRD2 Gene Transfer Into the Nucleus Accumbens Core of the Alcohol Preferring and Nonpreferring Rats in alcohol intake in Sprague Dawley rats. This overexpression of DRD2 reduced alcohol consumption in a two) and -nonpreferring (NP) rats. In addition, micro­positron emission tomography imaging was used at the completion

Homes, Christopher C.

186

The population genetic structure of the facultatively sexual parasitic nematode Strongyloides ratti in wild rats  

Science Journals Connector (OSTI)

...parasitic nematode Strongyloides ratti in wild rats M.C. Fisher M.E. Viney * * Author...parasitic nematode Strongyloides ratti in wild rats. In the UK, S. ratti reproduces predominantly...substantial genetic diversity was detected. Most rats were infected with a genotypic mixture...

1998-01-01T23:59:59.000Z

187

see commentary on page 1537 Artery calcification in uremic rats is increased by a  

E-Print Network [OSTI]

see commentary on page 1537 Artery calcification in uremic rats is increased by a low protein diet investigate medial artery calcification in adult rats made uremic by feeding a synthetic diet containing 0 increases the frequency and extent of medial artery calcification in uremic rats without significantly

Price, Paul A.

188

Enduring Effects of Early Life Stress on Firing Patterns of Hippocampal and Thalamocortical Neurons in Rats  

E-Print Network [OSTI]

in Rats: Implications for Limbic Epilepsy Idrish Ali1 , Patrick O'Brien1 , Gaurav Kumar1 , Thomas Zheng1-induced epileptogenesis in rats, but the underlying mechanisms are not well understood. Recent studies indicate of hippocampus as well as thalamic and cortical neurons. Eight week old male Wistar rats, previously exposed

Boyer, Edmond

189

Modulation of Biotransformation Systems and ABC Transporters by Benznidazole in Rats  

Science Journals Connector (OSTI)

...and ABC Transporters by Benznidazole in Rats Virginia G. Perdomo a Juan P. Rigalli...systems and ABC transporters was evaluated in rats. Expression of cytochrome P-450 (CYP3A...proteins in liver from BZL-treated rats were observed without changes in kidney...

Virginia G. Perdomo; Juan P. Rigalli; Silvina S. M. Villanueva; Mara L. Ruiz; Marcelo G. Luquita; Claudia G. Echenique; Viviana A. Catania

2013-07-22T23:59:59.000Z

190

The effects of ovariectomy on binge eating proneness in adult female rats Kelly L. Klump a,  

E-Print Network [OSTI]

)/binge eating prone (BEP) rat model. We predicted that palatable food consumption would significantly increase after ovariectomy in all rats because ovarian hormones generally suppress food intake. If differences and BEP rats would be eliminated or diminished after ovariectomy. Changes in palatable food (PF) intake

Sisk, Cheryl

191

Binge Eating Proneness Emerges During Puberty in Female Rats: A Longitudinal Study  

E-Print Network [OSTI]

little difference in palatable food intake between BER and BEP rats during pre-early pubertyBinge Eating Proneness Emerges During Puberty in Female Rats: A Longitudinal Study Kelly L. Klump eating during puberty in a rat model. We predicted that there would be minimal differences in binge

Sisk, Cheryl

192

Activities of amino acid metabolizing enzymes in the stomach and small intestine of developing rats  

E-Print Network [OSTI]

Activities of amino acid metabolizing enzymes in the stomach and small intestine of developing rats in the stomach and small intestine of developing rats. Despite the common embryonic origin of the intestine, significant metabolic changes take place in the rat ; these are enhanced by profound alterations in the size

Boyer, Edmond

193

Affective Analgesia Following Muscarinic Activation of the Ventral Tegmental Area in Rats  

E-Print Network [OSTI]

Affective Analgesia Following Muscarinic Activation of the Ventral Tegmental Area in Rats Robert G stimulation. Vocalization afterdischarges (VADs) are a validated model of the affective response of rats: Cholinergic activation of the brain reward circuit produced a preferential suppression of rats' affective

Borszcz, George S.

194

ARTICLE IN PRESS Oxalate, calcium and ash intake and excretion balances in fat sand rats  

E-Print Network [OSTI]

chelates Ca2+ , reducing Ca2+ availability in food and plasma (Concon, 1988). However, fat sand rats canARTICLE IN PRESS Oxalate, calcium and ash intake and excretion balances in fat sand rats (Psammomys Fat sand rats Psammomys obesus feed exclusively on plants of the family Chenopodiaceae, which contain

Vatnick, Itzick

195

that rats learn from conspecifics which foods are preferable by expe-  

E-Print Network [OSTI]

that rats learn from conspecifics which foods are preferable by expe- riencing the pairing of a distinctive (not necessarily novel) food odor with an odorous constituent of rat's breath (carbon disulfide used in humans, at least one of the elements of the as- sociation (the carbon disulfide in rats' breath

Gluck, Mark

196

Behavioural Processes, 13 (1986) 29-37 RUNNING AND DRINKING BY RATS OUTSIDE THE SCHEDULE SESSION  

E-Print Network [OSTI]

Behavioural Processes, 13 (1986) 29-37 Elsevier 29 RUNNING AND DRINKING BY RATS OUTSIDE by rats outside the schedule session. Behav. Processes 13: 29-37. Two experiments measured the effects of a contingency schedule relating running and eating on the behavior of rats during an "experimental hour

Timberlake, William D.

197

Ultrasonic vocalizations and social learning of food preferences by female Norway rats  

E-Print Network [OSTI]

Ultrasonic vocalizations and social learning of food preferences by female Norway rats BENNETT G the pair members were separated. However, the influence of demonstrator rats on food choices social learning of food preferences in Norway rats. ? 2004 The Association for the Study of Animal

Galef Jr., Bennett G.

198

JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR TIME HORIZONS IN RATS: THE EFFECT OF OPERANT  

E-Print Network [OSTI]

-independent access to less costly food at the average delay shown by the earned-time group. Rats in the matched to less costly food. Two of the earned-time rats showed an increased time horizon relative to that shown of food, progressive-ratio schedule, patches, lever press, rats In foraging for food, animals distribute

Timberlake, William D.

199

Social Transmission of Food Preferences: An Adaptation for Weaning in Rats  

E-Print Network [OSTI]

Social Transmission of Food Preferences: An Adaptation for Weaning in Rats Bennett G. Galef, Jr. Mc (Galef, 1976, 1977; Galef & Clark, 1971), Young rats seeking their first meals of solid food of adult conspecifics in locating solid foods. Thus, consideration of the problems faced by weanling rats

Galef Jr., Bennett G.

200

Yahoo! Health News: Rat Whiskers Give Clues to Blinking Disorder Yahoo! My Yahoo! Mail  

E-Print Network [OSTI]

Yahoo! Health News: Rat Whiskers Give Clues to Blinking Disorder Yahoo! My Yahoo! Mail Search · Encyclopedia A-Z · Health News via RSS · Recipes HealthDay All HealthDay News Rat Whiskers Give Clues, Feb. 2 (HealthDayNews) -- A rat's whiskers may hold vital clues to a debilitating human disorder

Kleinfeld, David

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Neural planning classifier for rats using stability Anonymous Author(s)  

E-Print Network [OSTI]

050 051 052 053 Neural planning classifier for rats using stability selection Anonymous Author(s) Affiliation Address email Abstract Neural excitation patterns were collected for rats performing one of two or task 1. If the classifier could distinguish between tasks, it may suggest that rats employ planning

de Freitas, Nando

202

ORIGINAL INVESTIGATION Attenuation of saccharin-seeking in rats by orexin/hypocretin  

E-Print Network [OSTI]

and reinstatement of sucrose-seeking elicited by sucrose-paired cues in food-restricted rats. Because sucrose rats were fed ad libitum or food-restricted and trained to self-administer saccharin. We determined similarly in food-restricted and ad libitum-fed rats. Conclusions These results indicate that signaling

Aston-Jones, Gary

203

Effects of 900 MHz radiofrequency on corticosterone, emotional memory and neuroinflammation in middle-aged rats.  

E-Print Network [OSTI]

in middle-aged rats. Marc Bouji, Anthony Lecomte, Yannick Hode, René de Seze, Anne-Sophie Villégier ABSTRACT) in the rat's brain after a single exposure to 900 MHz global system for mobile (GSM) signal, suggesting a potential inflammatory process. While this result was obtained in adult rats, no data is currently available

Boyer, Edmond

204

Current Flow in Vibrissa Motor Cortex Can Phase-Lock With Exploratory Rhythmic Whisking in Rat  

E-Print Network [OSTI]

that locks to this behavioral output. Rats were trained to whisk in air in search of a food reward. The EMGCurrent Flow in Vibrissa Motor Cortex Can Phase-Lock With Exploratory Rhythmic Whisking in Rat Kurt-lock with exploratory rhythmic whisking in rat. J Neurophysiol 92: 1700­1707, 2004. First published April 7, 2004; 10

Kleinfeld, David

205

Steiner Redish Supplemental Behavioral and neurophysiological correlates of regret in rat  

E-Print Network [OSTI]

Steiner Redish Supplemental 1 Behavioral and neurophysiological correlates of regret in rat whether rats were waiting for a specific tone before leaving, we measured the time spent at each zone encounter over all rats, over all sessions. Graph shows number of seconds spent waiting as a function

Cai, Long

206

Anim. Behav., 1996, 51, 765771 Use of foraging trails by Norway rats  

E-Print Network [OSTI]

was affected by the number of times it had been traversed by a rat on its way to and from food, but not by the amount of food a rat ate before depositing a trail. There was no evidence that trails contained information that would allow a rat to move directly towards food rather than directly away from it. Possible

Galef Jr., Bennett G.

207

5-Hydroxy-L-tryptophan suppresses food intake in food-deprived and stressed rats  

E-Print Network [OSTI]

5-Hydroxy-L-tryptophan suppresses food intake in food-deprived and stressed rats Ahmed Amera , Jeff consumption and tissue 5-HTP levels among rats subjected to two different hyperphagic stimuli, food in a 1- h feeding test in food-deprived rats. In this study, both serotonin and 5-HTP exhibited anorectic

Wurtman, Richard

208

Effect of a putative ER antagonist, MPP, on food intake in cycling and ovariectomized rats  

E-Print Network [OSTI]

Effect of a putative ER antagonist, MPP, on food intake in cycling and ovariectomized rats Jessica treatment alone is not sufficient to normalize food intake and weight gain in OVX rats, and progesterone plays a crucial role in controlling food intake in the female rat. Acting as an indirect control of meal

Hull, Elaine

209

Rat anterodorsal thalamic head direction neurons depend upon dynamic visual signals to select anchoring  

E-Print Network [OSTI]

Rat anterodorsal thalamic head direction neurons depend upon dynamic visual signals to select., 21, RC154,1­5]. Anterodorsal thalamic head direction cells were recorded while the rat foraged vantage point and separated by 90°. The rat was then disoriented in darkness, the cards were rotated by 90

Arleo, Angelo

210

Visual discrimination pretraining facilitates subsequent visual-cue-toxicosis conditioning in rats  

E-Print Network [OSTI]

to visually-novel foods. We found that rats which had been pretrained to use visual features of their foodVisual discrimination pretraining facilitates subsequent visual-cue-toxicosis conditioning in rats, Colorado 80309 #12;Abstract The present experiments were undertaken to determine whether rats, pre trained

Galef Jr., Bennett G.

211

Appetite, 1989, 13, 81-92 Enduring Social Enhancement of Rats' Preferences for  

E-Print Network [OSTI]

with rats have demonstrated substantial short-term social enhancement of preferences for foods (Galef, 1986 a choice between two approximately equipalatable foods (diets A and B), "observer" rats that had eachAppetite, 1989, 13, 81-92 Enduring Social Enhancement of Rats' Preferences for the Palatable

Galef Jr., Bennett G.

212

Sex and species differences in spatial memory in food-storing kangaroo rats  

E-Print Network [OSTI]

Sex and species differences in spatial memory in food-storing kangaroo rats CYNTHIA L. BARKLEY differences in spatial memory in two species of kangaroo rats that are predicted by foraging ecology. Merriam's kangaroo rat, Dipodomys merriami, a scatter hoarder that hoards intensively, showed ac- curate memory

Jacobs, Lucia

213

A single-unit analysis of reciprocal relationships between the lateral and medial hypothalamus in rats  

E-Print Network [OSTI]

in rats T. ROESCH Bernadette F?LIX Laboratoire de Physiologie des Centres Nerveux Université Pierre et units was studied in chronic awake and ketamine-anaesthetized rats. Ketamine appeared to decrease as 1939, Heterington and Ranson induced hyperphagia in rats by making electrolytic lesions

Boyer, Edmond

214

Monosodium Glutamate but not Linoleic Acid Differentially Activates Gustatory Neurons in the Rat Geniculate Ganglion  

E-Print Network [OSTI]

Monosodium Glutamate but not Linoleic Acid Differentially Activates Gustatory Neurons in the Rat) from gustatory neurons in the rat geniculate ganglion and none to free fatty acids. Accordingly, we recorded single-cell responses from geniculate ganglion gustatory neurons in anesthetized male rats to MSG

Hull, Elaine

215

Adrenalectomy eliminates the extinction spike in autoshaping with rats Brian L. Thomasa  

E-Print Network [OSTI]

rats are not required to press the lever in order to obtain food, they nonetheless approach and contactAdrenalectomy eliminates the extinction spike in autoshaping with rats Brian L. Thomasa , Mauricio rats, investigated the effect of adrenalectomy (ADX) on the invigoration of lever-contact performance

Cooper, Brenton G.

216

The influence of an essential fatty acid deficient-diet on the reproductive performance of female rats  

E-Print Network [OSTI]

rats Iris A. PARLANTI Liliana C. ORELLANA 1° Cátedra de Histología, Embriolo!ía y Genética, Facultad de Cbrdoba, Argentina. Summary. Several parameters of the reproductive function were studied in albino rats differences between EFAD and EFAS rats in any of the estrous cycle parameters studied. The EFAD rats showed

Paris-Sud XI, Université de

217

Calcium and -Tocopherol Suppress Cured Meat Promotion of Chemically-Induced Colon Carcinogenesis in Rats and Reduce  

E-Print Network [OSTI]

in Rats and Reduce Associated Biomarkers in Human Volunteers Fabrice H.F. Pierre1,7, Océane C.B. Martin1 and increases specific biomarkers in the colon of rats. Objectives: To investigate whether cured meat modulates preneoplastic lesions in rats, and associated biomarkers in rats and in humans. Design: Six additives (calcium

Paris-Sud XI, Université de

218

Salirasib (farnesyl thiosalicylic acid) for brain tumor treatment: a convection-enhanced drug delivery study in rats  

Science Journals Connector (OSTI)

...convection-enhanced drug delivery study in rats Liat Goldberg 1 Aharon Ocherashvilli 2...of the Ras oncogene in a 9L gliosarcoma rat model. The drug we used was salirasib...tumor growth rate in salirasib-treated rats relative to vehicle-treated rats as well...

Liat Goldberg; Aharon Ocherashvilli; Dianne Daniels; David Last; Zvi R. Cohen; Gregory Tamar; Yoel Kloog; Yael Mardor

2008-11-01T23:59:59.000Z

219

Body retention and tissue distribution of59Fe and 54Mn in newborn rats fed iron-supplemented cow's milk  

E-Print Network [OSTI]

Body retention and tissue distribution of59Fe and 54Mn in newborn rats fed iron-supplemented cow distribution has been studied in newborn rats. Six-day old rats, divided into three groups were artificially retention in newborn rats, whereas it enhanced 59Fe deposition in the liver and the intestinal wall and

Boyer, Edmond

220

Rats assess degree of relatedness from human odors Erin M. Ables a,b,, Leslie M. Kay a  

E-Print Network [OSTI]

Rats assess degree of relatedness from human odors Erin M. Ables a,b,, Leslie M. Kay a , Jill M objective odor qualities we tested odor similarity using rats in a habituation­discrimination paradigm. Rats compared. Because rats investigate novel odors longer than familiar odors, we were able to determine which

Mateo, Jill M.

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Sexual differences in the expression of copper deficiency in rats  

SciTech Connect (OSTI)

The present investigation was undertaken to establish whether the severity of copper deficiency in rats fed diets containing fructose is affected by the presence and type of endogenous sex hormones. Intact and castrated male rats and intact and ovariectomized females were fed from weaning a copper-deficient diet (0.6 ppm) containing 62% fructose for 8 weeks. Regardless of castration, male rats were anemic, exhibited heart hypertrophy, and died of the deficiency. However, castration ameliorated the anemia and delayed the mortality. In contrast, none of the females died of the deficiency. It is suggested that in addition to the sex of the animal, levels of testosterone in the male may also play a role in the severity of copper deficiency.

Fields, M.; Lewis, C.G.; Beal, T.; Scholfield, D.; Patterson, K.; Smith, J.C.; Reiser, S.

1987-11-01T23:59:59.000Z

222

Blocking long term consolidation of extinction in rats with puromycin  

E-Print Network [OSTI]

BLOCKING LONG T RN CONSOLIDATION CF EXTINCTION IN RATS NITH PURO", 1YCIN A Thesis by WILLIAM. JOS PH BROUSSARD Submitted to the Graduate College of Texas A%51 University in Partial fulfillment of the requirement for the degree of I". ASTHR... OF SCIBNC August 1972 )major Subject: Psychology BLOCKING LONG TERM CONSOLIDATION OF EXTINCTION IN RATS WI ' H PUROMYCIN A Thesis WILLIAM JOSEPH BROUSSARD Approved as to style and content by~ c'F, ~ g, Chairman of Co j. ttee H o e ar men Mem er...

Broussard, William Joseph

2012-06-07T23:59:59.000Z

223

A targeted multiplexed proteomic investigation identifies ketamine-induced changes in immune markers in rat serum and expression changes in protein kinases/phosphatases in rat brain  

Science Journals Connector (OSTI)

A targeted multiplexed proteomic investigation identifies ketamine-induced changes in immune markers in rat serum and expression changes in protein kinases/phosphatases in rat brain ... Here we investigated proteomic changes in brain and serum after acute treatment of rats with ketamine using two targeted proteomic profiling methods. ... Multiplex immunoassay profiling of serum identified altered levels of IL-4, TNF? and FGF-9, suggesting a link between ketamine exposure and peripheral inflammation and growth factor dysregulation. Selected reaction monitoring mass spectrometry (SRM-MS) profiling of rat brain tissue found that proteomic changes occurred in the frontal cortex and to a greater extent in the hippocampus. ...

Hendrik Wesseling; Hassan Rahmoune; Mark Tricklebank; Paul C. Guest; Sabine Bahn

2014-11-02T23:59:59.000Z

224

Neutron-induced Mammary Neoplasms in the Rat  

Science Journals Connector (OSTI)

...Research, Inc. May 1972 research-article Neutron-induced Mammary Neoplasms in the Rat...Medicine, Memphis, Tennessee 38103 Fission neutrons are effective in producing mammary neoplasms...does not hold after exposure to fission neutrons, at least from 10 to 250 rads, in single...

Howard H. Vogel, Jr. and Robert Zaldvar

1972-05-01T23:59:59.000Z

225

Hypoxia Stimulates Vesicular ATP Release From Rat Osteoblasts  

E-Print Network [OSTI]

Hypoxia Stimulates Vesicular ATP Release From Rat Osteoblasts ISABEL R. ORRISS,1 GILLIAN E. KNIGHT, University of Surrey, Guildford, UK Many neuronal and non-neuronal cell types release ATP in a controlled manner. After release, extracellular ATP (or, following hydrolysis, ADP) acts on cells in a paracrine

Burnstock, Geoffrey

226

Regional neurohypophysial and hypothalamic blood flow in rats during hypercapnia  

SciTech Connect (OSTI)

Regional cerebral blood flow (rCBF) was measured in the neurohypophysis and hypothalamus in normocapnic and hypercapnic rats using (/sup 14/C)isopropyliodoamphetamine. Rats were surgically prepared using nitrous oxide and halothane and placed in plaster restraining casts. Hypercapnia was produced by increasing the fractional concentration of inspired CO/sub 2/ (FICO/sub 2/). rCBF in normocapnic rats was higher in the paraventricular nucleus, supraoptic nucleus, median eminence, and neural lobe than rates previously measured by use of diffusible tracers. During hypercapnia blood flow increased linearly with arterial PCO/sub 2/ (PACO/sub 2/) in all regions except the median eminence and neural lobe, which were not affected by hypercapnia. When rats were pretreated with phentolamine (1 mg/kg) to block the alpha-adrenergic receptors, blood flow in the median eminence and neural lobe increased significantly during hypercapnia. We conclude that blood flow in the cell bodies of the paraventricular nucleus and supraoptic nucleus is regulated differently during hypercapnia than blood flow in the nerve terminals in the median eminence and neural lobe. Furthermore, vasodilation produced by increased CO/sub 2/ is offset by alpha-receptor stimulation in the median eminence and neural lobe.

Bryan, R.M. Jr.; Myers, C.L.; Page, R.B.

1988-08-01T23:59:59.000Z

227

Characterization of a plasma membrane zinc transporter in rat brain  

E-Print Network [OSTI]

Ireland Ltd. Keywords: Ion transport; Membrane vesicles; Excitotoxicity; Zinc homeostasis; TransitionCharacterization of a plasma membrane zinc transporter in rat brain Robert A. Colvin* Department transport in the brain. This report provides convincing evidence of a zinc transporter in plasma membrane

228

Methamphetamine self-administration in rats developmentally exposed to lead  

E-Print Network [OSTI]

to examine the effects of perinatal lead exposure on adult self-administration of intravenous (i.v.) methamphetamine across all relevant transition points of drug addiction. Adult female rats were administered a 16-mg lead or a control solution for 30 days...

Rocha, Angelica

2009-05-15T23:59:59.000Z

229

Single Glucose Biofuel Cells Implanted in Rats Power Electronic Devices  

E-Print Network [OSTI]

Single Glucose Biofuel Cells Implanted in Rats Power Electronic Devices A. Zebda1,2 , S. Cosnier1 the first implanted glucose biofuel cell (GBFC) that is capable of generating sufficient power from a mammal further developments. Following recent developments in nano- and biotechnology, state-of-the-art biofuel

Boyer, Edmond

230

Cholesterol Metabolism in Rats Bearing Morris Hepatoma 7777  

Science Journals Connector (OSTI)

...diet of D & G laboratory chow (Price-Wilhoite Co., Frederick...triacylglycerols into tubes and then heating with 2 ml of 2% H2S04 in methanol...The latter was prepared by heating 3 ml of serum from control rats...Silver Nitrate-TLC. J. Am. Oil Chem. Soc., 42: 87-90...

M. R. Grigor; M. L. Blank; and Fred Snyder

1973-08-01T23:59:59.000Z

231

Facial Wiping in the Rat Fetus: Variation of Chemosensory  

E-Print Network [OSTI]

how variation in stimulus parameters of lemon odor infusion (concentration, volume, and infusion time) affected the wiping response of E20 rat fetuses. Infusions of higher concentration or greater volume of stimulation. Intraoral infusion of chemosensory fluids with strong olfactory components, such as lemon extract

Robinson, Scott R.

232

Impairment of Timing Behavior after Prolonged Alcohol Consumption in Rats  

Science Journals Connector (OSTI)

...and performance of DRL 30 days after alcohol was omitted from the diet. Twenty-four male Sprague-Dawley rats (Carworth CFE strain), 90 days old, were reduced to 85 percent of their body weights (when they were fed freely) and were trained to press...

Don W. Walker; Gerhard Freund

1973-11-09T23:59:59.000Z

233

JNK and IKK? phosphorylation is reduced by glucocorticoids in adipose tissue from insulin-resistant rats  

Science Journals Connector (OSTI)

AbstractObjectives Peripheral insulin resistance (IR) is one of the main side effects caused by glucocorticoid (GC)-based therapies, and the molecular mechanisms of GC-induced IR are not yet fully elucidated. Thus, we aimed to investigate the effects of dexamethasone treatment on the main components of insulin and inflammatory signaling in the adipose tissue of rats. Materials/methods Male Wistar rats received daily injections of dexamethasone (1mg/kg body weight (b.w.), intraperitoneally (i.p.)) for 5 days (DEX), whereas control rats received saline (CTL). The metabolic status was investigated, and the epididymal fat fragments were collected for lipolysis and western blot analyses. Results The DEX rats became hyperglycemic, hyperinsulinemic, insulin resistant and glucose intolerant, compared with the CTL rats (Prats (Prats after an oral bolus of glucose (Prats (Prats (Prats induced by dexamethasone administration have PKB and IRS-1 activity attenuated in epididymal fat without increases in the phosphorylation of the proinflammatory signals JNK and IKK?.

Katia Motta; Amanda Marreiro Barbosa; Franciane Bobinski; Antonio Carlos Boschero; Alex Rafacho

2015-01-01T23:59:59.000Z

234

Comparative metabolism of phenobarbitone in the rat (CFE) and mouse (CF1)  

Science Journals Connector (OSTI)

The fate of orally administered [14C]phenobarbitone (40 mg/kg) was studied comparatively in CFE rats and CF1 mice. Metabolism and elimination were rapid. Hydroxylation was more complete in rats than in mice but the major metabolite in both species was p-hydroxyphenobarbitone, which was excreted mostly in the urine in both free and conjugated form. Unmetabolized phenobarbitone was excreted in the urine of both rat and mouse. Two minor metabolites appeared to be common to both species. The effect of pretreatment with non-radioactive phenobarbitone on the metabolism of [14C]phenobarbitone was minimal in the rat but afforded a twofold increase in p-hydroxylation in the mouse (in vivo). Despite the good yield of p-hydroxyphenobarbitone in the intact rat, [14C]phenobarbitone was not metabolized by liver-microsomal preparations from either untreated or phenobarbitone-induced rats.

J.V. Crayford; D.H. Hutson

1980-01-01T23:59:59.000Z

235

Brain reward deficits accompany withdrawal (hangover) from acute ethanol in rats  

E-Print Network [OSTI]

stimulation reward: effects of ethanol. Alcohol Clin Exp Resstimulus produced by ethanol withdrawal. J Pharmacol Expthe "anxiogenic" response to ethanol withdrawal in the rat.

Schulteis, Gery; Liu, Jian

2006-01-01T23:59:59.000Z

236

Actinomycin D and the Regulation of Apoferritin Synthesis in Rat Liver  

Science Journals Connector (OSTI)

... Male albino rats of tho Sherman strain weighing 150-250 g were fasted for 18 h in metabolism cages, lightly ...

YOSHIO YOSHINO; JAMES MANIS; DAVID SCHACHTER

1966-04-30T23:59:59.000Z

237

E-Print Network 3.0 - awake rats achieving Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

<< < 1 2 3 4 5 > >> 1 Anticorrelated resting-state functional connectivity in awake rat brain Zhifeng Liang, Jean King, Nanyin Zhang Summary: Anticorrelated resting-state...

238

E-Print Network 3.0 - adult rat brain Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

brain Search Powered by Explorit Topic List Advanced Search Sample search results for: adult rat brain Page: << < 1 2 3 4 5 > >> 1 Damageduring prenataldevelopmentof certainbrain...

239

E-Print Network 3.0 - adult rat retina Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: adult rat retina Page: << < 1 2 3 4 5 > >> 1 Developmental Brain Research 102 1997 267273 Research report Summary: of synaptophysin, synapsin I and...

240

E-Print Network 3.0 - adult rats neuroprotection Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

magnocellular nucleus basalis: neuroprotection by Ca(2... levels in rats: effects on brain 5-HT1A receptors and behavioral coping with stress in adult offspring... in adult...

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Supersensitive?-adrenergic receptors are down-regulated in rat brain by mianserin administration  

Science Journals Connector (OSTI)

Experiments were undertaken to determine whether alterations in rat brain monoaminergic tone influence the manner in which mianserin administration modifies?-adrenergic receptor function. Whereas the chronic admi...

A. Pilc; S. J. Enna

1987-01-01T23:59:59.000Z

242

E-Print Network 3.0 - adult rat prefrontal Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mem. Summary: of prefrontal neural activity in the rat to the acquisition of trace fear conditioning using microinfusions... was performed on a total of 120 adult male...

243

E-Print Network 3.0 - alloxan-treated rats beneficial Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in a panel of 11 different inbred rat strains to evaluate the genetic variance Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo...

244

E-Print Network 3.0 - atrophic fetal rat Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

lesion, but the effects of interventions that Summary: included 77 motoneurons from 19 rats. The transected group that received fetal tissue trans- plants... of fetal spinal cord...

245

E-Print Network 3.0 - acutely dissociated rat Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: h or 15 d after pellet removal. We confirmed that acute morphine in naive rats produced a marked... .Inratsthathadspontaneouswithdrawalafter24hor15d,theactivityofVTAD...

246

E-Print Network 3.0 - adult rat sensory Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

>> 1 ELECTRICAL STIMULATION REDUCES AGE RELATED ATROPHY AND WEAKNESS IN EDL MUSCLES OF RATS Summary: the atrophy and weakness. We electrically stimulated EDL muscles of adult and...

247

E-Print Network 3.0 - anterior repositioned rat Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Task? Evidence for Distinct Contributions to a Movement Vector Summary: ). Discussion Rats were trained to navigate to a fixed hidden platform, after which the pool was...

248

E-Print Network 3.0 - adult rat cardiomyocytes Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Grafts Summary: and Results--Cardiomyocytes from fetal, neonatal, or adult inbred rats were grafted into normal myocardium... and resuspended in 70 L of serum-free medium...

249

E-Print Network 3.0 - adult rat lung Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

different volumes of inflation." J. Acoust. Soc... -dependent impedance of lungs from rats, rabbits, and pigs ... Source: Illinois at Urbana-Champaign, University of -...

250

E-Print Network 3.0 - audiogenic rat strain Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

recruitment during the development of audiogenic kindling in seizure susceptible Wistar rats... -Cairasco, N., 2000. Audiogenic kindling in the Wistar ... Source: Bruno, John P. -...

251

Sorbitol accumulation in male and female rats consuming starch or fructose diets with or without copper  

SciTech Connect (OSTI)

The present study was designed to examine the relationship between the sex of the rats, tissue sorbitol accumulation and copper deficiency in rats consuming dietary fructose. Rats were provided with a diet containing either 62.7% fructose or starch, and either 6.0 or 0.6 {mu}g copper/g for three weeks. Hepatic copper concentration of all rats consuming the copper-deficient diets was about 40% of copper sufficient rats. Hepatic, renal and thymic sorbitol concentrations were significantly elevated in males consuming the fructose, copper-deficient diet when compared to all other dietary groups regardless of the sex of the rat. Hepatic, renal the thymic fructose concentrations were significantly higher in rats eating fructose as compared to female rats. Hepatic glucose concentration was higher in males and females consuming the fructose, copper-deficient diet when compared to all other dietary groups. Renal glucose concentration was elevated in males as compared to females. These results demonstrate that the pathology and complications of copper deficiency in the male rat consuming fructose closely parallel aberration in tissue sorbitol accumulation.

Lewis, C.G.; Fields, M.; Beal, T. (Dept. of Agriculture, Beltsville, MD (USA))

1989-02-09T23:59:59.000Z

252

PyRAT (python radiography analysis tool): overview  

SciTech Connect (OSTI)

PyRAT was developed as a quantitative tool for robustly characterizing objects from radiographs to solve problems such as the hybrid nonlinear inverse problem. The optimization software library that was used is the nonsmooth optimization by MADS algorithm (NOMAD). Some of PyRAT's features are: (1) hybrid nonlinear inverse problem with calculated x-ray spectrum and detector response; (2) optimization based inversion approach with goal of identifying unknown object configurations - MVO problem; (3) using functionalities of Python libraries for radiographic image processing and analysis; (4) using the Tikhonov regularization method of linear inverse problem to recover partial information of object configurations; (5) using a priori knowledge of problem solutions to define feasible region and discrete neighbor for the MVO problem - initial data analysis + material library {yields} a priori knowledge; and (6) using the NOMAD (C++ version) software in the object.

Armstrong, Jerawan C [Los Alamos National Laboratory; Temple, Brian A [Los Alamos National Laboratory; Buescher, Kevin L [Los Alamos National Laboratory

2011-01-14T23:59:59.000Z

253

PyRAT - python radiography analysis tool (u)  

SciTech Connect (OSTI)

PyRAT is a radiography analysis tool used to reconstruction images of unknown 1-0 objects. The tool is written in Python and developed for use on LINUX and Windows platforms. The tool is capable of performing nonlinear inversions of the images with minimal manual interaction in the optimization process. The tool utilizes the NOMAD mixed variable optimization tool to perform the optimization.

Temple, Brian A [Los Alamos National Laboratory; Buescher, Kevin L [Los Alamos National Laboratory; Armstrong, Jerawan C [Los Alamos National Laboratory

2011-01-14T23:59:59.000Z

254

Monosodium glutamate induced testicular lesions in rats (histological study)  

Science Journals Connector (OSTI)

AbstractObjective Monosodium glutamate (MSG) commonly consumed as a flavor enhancer and food additive in most soup, salad, and processed meat. The present study was designed to investigate the effect of MSG on testes of young male Wistar rats (n=30). Materials and methods They were randomly assigned into One control group C (n=10) received distilled water and two treatment groups A and B (n=10) were given oral daily doses of MSG 30 and 60g/kg body weight respectively for 2 months. Results The body weight of rats was significantly increased and mainly histological alterations which included of hyaline material in the lumina of the seminiferous tubules and interstitial tissues and exfoliation of spermatocytes and spermatids in treated group. Many cells of the different types of spermatogenesis appeared necrotic with pyknotic nuclei. Dilated congested blood vessels and vacuolar degeneration were also been observed in the cells of seminiferous tubules in the treated group B. Conclusions MSG may have some deleterious effects on the testes of Wistar rats and by extension may contribute to the causes of male infertility. Thus, it is important to reconsider the usage of MSG as a flavor enhancer.

Aisha D. Alalwani

2014-01-01T23:59:59.000Z

255

Influence of daily feeding within a limited time on weight, digestive transit and cholesterol turnover in adult rats  

E-Print Network [OSTI]

turnover in adult rats T. MAGOT, F. CHEVALLIER Laboratoire de Physiologie de la Nutrition (*),), Université de Paris-Sud, Bâtiment 447 91405 Orsay Cedex, France. Summary. Rats were trained to a single daily the first hour. This value defined the average volumic capacity of the full stomach of our rats. Body weight

Paris-Sud XI, Université de

256

Systemic Administration of a Conditionally Replicating Adenovirus, Targeted to Angiogenesis, Reduced Lung Metastases Burden in Cotton Rats  

Science Journals Connector (OSTI)

...Reduced Lung Metastases Burden in Cotton Rats Michael Peled 1 2 4 Aviv Shaish 1 2 Avi...AdPPE3x-E1 was also tested in a cotton rat lung metastases model. Results: The replication...reduced the lung metastases burden in a cotton rat model by 55, compared with saline-treated...

Michael Peled; Aviv Shaish; Avi Katav; Shoshana Greenberger; Iris Barshack; Reshef Tal; Livnat Bangio; Eyal Breitbart; Dror Harats

2009-03-01T23:59:59.000Z

257

Effect of various modifications in the diet on ileal epithelium renewal in germ-free and conventional rats  

E-Print Network [OSTI]

-free and conventional rats J. C. MESLIN, E. SACQUET M. RIOTTOT Michèle SEREZAT Station de Recherches de Nutrition, 1.N) and conventional (CV) rats fed with a semi-synthetic diet in the following forms : a) pellets steri- lized by autoclaving (Pel. Au. diet) ; b) powder sterilized by gamma irradiation ; when given to the rats, its weight

Paris-Sud XI, Université de

258

Preweanling Rats Solve the Morris Water Task via Directional Navigation Katherine G. Akers, Felicha T. Candelaria, and Derek A. Hamilton  

E-Print Network [OSTI]

Preweanling Rats Solve the Morris Water Task via Directional Navigation Katherine G. Akers, Felicha T. Candelaria, and Derek A. Hamilton University of New Mexico Adult rats show a preference preweanling rats with a newly developed ability to perform the water task also solve the task via directional

Hamilton, Derek

259

Dietary Supplementation with Silymarin Inhibits 3,2?-Dimethyl-4-AminobiphenylInduced Prostate Carcinogenesis in Male F344 Rats  

Science Journals Connector (OSTI)

...2-Dimethyl-4-Aminobiphenyl-Induced Prostate Carcinogenesis in Male F344 Rats Hiroyuki Kohno 1 Requests for reprints: Hiroyuki...induced prostatic carcinogenesis in male F344 rats. Experimental Design: Male F344 rats were given s.c. injections of DMAB (25 mg...

Hiroyuki Kohno; Rikako Suzuki; Shigeyuki Sugie; Hiroyuki Tsuda; Takuji Tanaka

2005-07-01T23:59:59.000Z

260

Dissociable Effects of Lesions to the Perirhinal Cortex and the Postrhinal Cortex on Memory for Context and Objects in Rats  

E-Print Network [OSTI]

for Context and Objects in Rats G. Norman and M. J. Eacott University of Durham Memory for the context. Sham-operated rats explore familiar objects appearing in incongruent but familiar contexts more than appeared. At short delays, perirhinal cortex-lesioned rats were unimpaired on memory for object in context

Wagner, Anthony

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Higher doses of bisphosphonates further improve bone mass, architecture, and strength but not the tissue material properties in aged rats  

E-Print Network [OSTI]

but not the tissue material properties in aged rats Mohammad Shahnazari a , Wei Yao a , WeiWei Dai a , Bob Wang in aged osteopenic rats to explain how bone material and bone mass may be affected by the dose of bisphosphonates (BP) and contribute to their anti- fracture efficacy. Eighteen-month old female rats underwent

Ritchie, Robert

262

Beacon Training in a Water Maze Can Facilitate and Compete With Subsequent Room Cue Learning in Rats  

E-Print Network [OSTI]

in Rats William Timberlake, Susan A. Sinning, and Joseph K. Leffel Indiana University In Stage 1 of 4 experiments in which rats completed a water-maze blocking procedure, experimental groups were trained to use examined Tolman, Ritchie, and Kalish's (1946) conclusion that rats learned the loca- tion of a reward

Indiana University

263

Diffusion Tensor Imaging to Track Changes in Skeletal Muscle Architecture of Sarcopenic Rats I. S. Masad1,2  

E-Print Network [OSTI]

Diffusion Tensor Imaging to Track Changes in Skeletal Muscle Architecture of Sarcopenic Rats I. S dimensions (MD) and characteristics of the rat soleus muscle are investigated using DTI. Methods: Experimental setup: Eighteen Fisher 344 male rats were divided into four groups based on their age at the time

McQuade, D. Tyler

264

Environmental levels of oestrogenic and antiandrogenic compounds feminize digit ratios in male rats and their unexposed male progeny  

Science Journals Connector (OSTI)

...compounds feminize digit ratios in male rats and their unexposed male progeny Jacques...studied the effect on adult male Wistar rat digit ratios of a gestational exposure to...dimorphism of digit ratios in the Wistar rat, and we found that BPA alone or in combination...

2013-01-01T23:59:59.000Z

265

Synergistic Antitumor Response of Interleukin 2 with Melphalan in Isolated Limb Perfusion in Soft Tissue SarcomaBearing Rats  

Science Journals Connector (OSTI)

...Perfusion in Soft Tissue Sarcoma-Bearing Rats Saske Hoving 1 Flavia Brunstein 1 Gisela...well-established ILP in soft tissue sarcoma-bearing rats (BN175). ILP with either IL-2 or melphalan...melphalan|isolated limb perfusion|rat|soft tissue sarcoma| Introduction We...

Saske Hoving; Flavia Brunstein; Gisela aan de Wiel-Ambagtsheer; Sandra T. van Tiel; Gert de Boeck; Ernst A. de Bruijn; Alexander M.M. Eggermont; Timo L.M. ten Hagen

2005-05-15T23:59:59.000Z

266

Influence of oral MCT or LCT load on glycemia in Wistar and Zucker rats and in guinea pigs  

E-Print Network [OSTI]

Influence of oral MCT or LCT load on glycemia in Wistar and Zucker rats and in guinea pigs A. BACH! to C12) in non-fasting Wistar rats induced a decrease in plasma levels of lactate, pyruvate and glucose load. Post-MCT hypoglycemia was also observed in previously fasting rats and was definitely determined

Paris-Sud XI, Université de

267

Effect of different modifications of a semi-synthetic diet on bile acid metabolism in axenic and holoxenic rats  

E-Print Network [OSTI]

and holoxenic rats E. SACQUET C. LEPRINCE, M. RIOTTOT Laboratoire des animaux sans germes du C. N. R. S., I. N. R. A., 78350, Jouy-en-Josas. Summary. Axenic (germfree) and holoxenic (conventional) rats were fed was offered to the rats in the form of pellets and the irradiated diet in the form of a paste. Important

Boyer, Edmond

268

The degree of bone mineralization is maintained with single intravenous bisphosphonates in aged estrogen-deficient rats and  

E-Print Network [OSTI]

estrogen-deficient rats and is a strong predictor of bone strength Wei Yao a , Zhiqiang Cheng a , Kurt J rats were ovariectomized and treated with a single dose of risedronate (intravenous, iv, 500 g was not changed with OVX or with anti-resorptive treatments. In conclusion, in the aged estrogen-deficient rat

Ritchie, Robert

269

Treatment with 8-OH-DPAT attenuates the weight loss associated with activity-based anorexia in female rats  

E-Print Network [OSTI]

in female rats Deann P.D. Atchley, Lisa A. Eckel Program in Neuroscience and Department of Psychology the effects of pharmacological manipulation of the 5-HT system in female rats exposed to conditions that promote activity-based anorexia (ABA). In this animal model of anorexia nervosa, rats are food restricted

Hull, Elaine

270

Role of Residual Olfactory Cues in the Determination of Feeding Site Selection and Exploration Patterns of Domestic Rats  

E-Print Network [OSTI]

of feeding on solid food, weanling domesticated rat pups exhibit a strong preference for a relatively rats at a feeding location, to attract weanlings to a food source utilized by conspecifics Patterns of Domestic Rats Bennett G. Galef, Jr., and Linda Heiber McMaster University, Hamilton, Canada

Galef Jr., Bennett G.

271

Association learning-dependent increases in acetylcholine release in the rat auditory cortex during auditory classical conditioning  

E-Print Network [OSTI]

Association learning-dependent increases in acetylcholine release in the rat auditory cortex during of acetylcholine (ACh) in the pri- mary auditory cortex in rats. Samples of ACh were collected via microdialysis in the conditioning group as rats acquired the CR, but did not change in the control group, which did not acquire a CR

Weinberger, Norman M.

272

Influence of photoperiod on the time of birth in the rat. IV. Effects of an imposed feeding rhythm  

E-Print Network [OSTI]

et al., 1980 ; Miyabo et al., 1980). Periodic food distribution has often been utilized in ratsInfluence of photoperiod on the time of birth in the rat. IV. Effects of an imposed feeding rhythm on the time of birth in rats, the onset of fetus expulsion was determined in six experimental groups. Under

Boyer, Edmond

273

Estrogen increases the taste threshold for sucrose in rats Kathleen S. Curtis *, Jennifer M. Stratford, Robert J. Contreras  

E-Print Network [OSTI]

' preferences for sweet foods are affected by hormonal fluctuations across the reproductive cycle. In rats in these differences as well. Feeding fluctuates across the estrus cycle in rats, with lowest levels of food intake associated with high levels of estrogen [15,25]. Moreover, ovariectomized rats consume more food than do

Hull, Elaine

274

Anim. Behav., 1995, 49, 403409 Groups of naive rats learn to select nutritionally adequate foods faster than  

E-Print Network [OSTI]

Anim. Behav., 1995, 49, 403­409 Groups of naive rats learn to select nutritionally adequate foods weanling rats offered a choice of four foods (three both relatively palatable and protein- deficient diet from an array of adequate and deficient foods than would rat pups weaning in isolation. We offered

Galef Jr., Bennett G.

275

LEARNING AND MOTIVATION 21, 153-163 (I!%)) Winning Isn't Everything: Rats Need Only Food Deprivation  

E-Print Network [OSTI]

LEARNING AND MOTIVATION 21, 153-163 (I!%)) Winning Isn't Everything: Rats Need Only Food determinant of efficient performance on the radial maze. Food-de- prived and nondeprived rats were run on a large-platformed, S-arm radial maze that was either baited or unbaited. Food-deprived rats that were

Timberlake, William D.

276

Background, But Not Foreground, Spatial Cues Are Taken as References for Head Direction Responses by Rat Anterodorsal  

E-Print Network [OSTI]

. In recordings in which rats forage for food in cylindrical enclosures, rotation of a contrasted card along by Rat Anterodorsal Thalamus Neurons Michae¨ l B. Zugaro, Alain Berthoz, and Sidney I. Wiener Centre before and after the group of objects was rotated. (The rat was disoriented in total darkness between

Sereno, Martin

277

Anim. Behav., 1991,41,295-301 Information centres of Norway rats: sites for information exchange and  

E-Print Network [OSTI]

interacting, both members of a pair of rats, each of which had just eaten a different, novel food exhibited to impart about available foods) and 'observer' rats (i.e. naive animals that were given the opportunity, observer rats exhibit enhanced preferences for the foods eaten by their respective demonstrators (Galef

Galef Jr., Bennett G.

278

~nlfl1. &/IlW. 19H7. 35, ~ Paper ~H5 Hungry rats' following of conspecifics to food  

E-Print Network [OSTI]

~nlfl1. &/IlW. 19H7. 35, ~ Paper ~H5 Hungry rats' following of conspecifics to food depends the conditions under which a hungry rat would sponta- neously follow a recently fed conspecitic to food food more frequently than they would follow recently fed rats that had eaten an undesir- able food

Galef Jr., Bennett G.

279

Failure to find aversive marking of toxic foods by Norway rats BENNETT G. GALEF, JR, SHANNON PRETTY & ELAINE E. WHISKIN  

E-Print Network [OSTI]

Failure to find aversive marking of toxic foods by Norway rats BENNETT G. GALEF, JR, SHANNON PRETTY in an area soiled by demonstrators that had not learned to avoid the food, the naive rats ate an equal amount rats to learn socially to avoid foods in areas that conspecifics soil after becoming ill. ? 2006

Galef Jr., Bennett G.

280

The Behavioral Deficit Observed Following Noncontingent Shock in Spinalized Rats Is Prevented by the Protein Synthesis Inhibitor  

E-Print Network [OSTI]

The Behavioral Deficit Observed Following Noncontingent Shock in Spinalized Rats Is Prevented. Crown, and James W. Grau Texas A&M University Spinalized rats that receive shock when 1 hind limb. Rats that receive shock independent of leg position (noncontingent shock) do not exhibit an increase

Grau, James

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Research Report Effects of ethanol consumption by adult female rats on subsequent  

E-Print Network [OSTI]

Research Report Effects of ethanol consumption by adult female rats on subsequent consumption January 2004 Abstract We used a two-bottle choice test to measure voluntary ethanol consumption by adolescent rats that had lived with ethanol-consuming or water-consuming adult conspecifics. We found

Galef Jr., Bennett G.

282

pH dependence and compartmentalization of zinc transported across plasma membrane of rat cortical neurons  

E-Print Network [OSTI]

pH dependence and compartmentalization of zinc transported across plasma membrane of rat corticalH dependence and compartmental- ization of zinc transported across plasma membrane of rat cortical neurons. Am; ion transport; transition elements; primary culture IT IS KNOWN THAT Zn2 can enter neurons by two

283

Dietary L-arginine supplementation reduces fat mass in diet-induced obese rats  

E-Print Network [OSTI]

rats continued to be fed their same respective diets and received drinking water containing either 1.51% L-arginine-HCl or 2.55% alanine (isonitrogenous control) (n=8/treatment group). Twelve weeks after the initiation of the arginine treatment, rats...

Jobgen, Wenjuan Shi

2009-06-02T23:59:59.000Z

284

TURNING BACK THE CLOCK: CGP55845 REVERSES MILD COGNITIVE IMPAIRMENT IN FISCHER 344 RATS  

E-Print Network [OSTI]

= 10) F344 rats. Animals were given CGP55845 40 minutes prior to testing in the odor discrimination task. This task is particularly useful for pharmacological studies, since it allows for a within subjects design. Although only a subset of aged rats...

Mayse, Jeffrey

2011-01-11T23:59:59.000Z

285

Improved rat genome gene prediction by integration of ESTs with RNA-Seq information  

Science Journals Connector (OSTI)

......from three rat tissues-bone marrow, brain and kidney-with EST data to improve the...data from three rat tissues (kidney, brain and bone marrow) into a gene prediction...experiments Tissues from bone marrow, brain and kidney were harvested from BN or Sprague......

Liping Li; Enguo Chen; Chun Yang; Jun Zhu; Pushkala Jayaraman; Jeffrey De Pons; Catherine C. Kaczorowski; Howard J. Jacob; Andrew S. Greene; Matthew R. Hodges; Allen W. Cowley; Jr; Mingyu Liang; Haiming Xu; Pengyuan Liu; Yan Lu

2015-01-01T23:59:59.000Z

286

A Sucrose-rich Diet Induces Mutations in the Rat Colon  

Science Journals Connector (OSTI)

...the genotoxic response in the rat...the overall energy and carbohydrate...the mutation frequency at the cII...nitrogen until storage at C. The...increases mutation frequencies. Biochem...the genotoxic response in the rat...the overall energy and carbohydrate...the mutation frequency at the cII...

Lars O. Dragsted; Bahram Daneshvar; Ulla Vogel; Herman N. Autrup; Hkan Wallin; Lotte Risom; Peter Mller; Anne M. Mlck; Max Hansen; Henrik E. Poulsen; and Steffen Loft

2002-08-01T23:59:59.000Z

287

Improved rat genome gene prediction by integration of ESTs with RNA-Seq information  

Science Journals Connector (OSTI)

......from three rat tissues-bone marrow, brain and kidney-with EST data to improve the...data from three rat tissues (kidney, brain and bone marrow) into a gene prediction...experiments Tissues from bone marrow, brain and kidney were harvested from BN or Sprague......

Liping Li; Enguo Chen; Chun Yang; Jun Zhu; Pushkala Jayaraman; Jeffrey De Pons; Catherine C. Kaczorowski; Howard J. Jacob; Andrew S. Greene; Matthew R. Hodges; Allen W. Cowley; Jr; Mingyu Liang; Haiming Xu; Pengyuan Liu; Yan Lu

2014-10-01T23:59:59.000Z

288

MAGNESIUM ABSORPTION IN THE CCUM OF RATS RELATED TO VOLATILE FATTY ACIDS PRODUCTION  

E-Print Network [OSTI]

MAGNESIUM ABSORPTION IN THE C?CUM OF RATS RELATED TO VOLATILE FATTY ACIDS PRODUCTION Y. RAYSSIGUIER RELATIONS ENTRE L'ABSORPTION C,4ECALE DE MAGNESIUM CHEZ LE RAT ET LA PRODUCTION D'ACIDES GRAS VOLATILS du caecum, pH, acides gras volatils, activité microbienne. Introduction The mode of magnesium

Paris-Sud XI, Université de

289

Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel  

Science Journals Connector (OSTI)

...agar supplemented with either IL-3 or SLF. The threshold concentration of growth...murine IL-3 (1 to 500 pg/mI) or rat SLF (0.3 to 100 ng/mi). Triplicate cultures...Zsebo (Amgen) for murine GM-CSF, rat SLF, human G-CSF, human IL-6, and human...

LL Isom; KS De Jongh; DE Patton; BF Reber; J Offord; H Charbonneau; K Walsh; AL Goldin; WA Catterall

1992-05-08T23:59:59.000Z

290

Structural and functional effects of social isolation on the hippocampus of rats with traumatic brain injury  

Science Journals Connector (OSTI)

Abstract Social isolation has significant long-term psychological and physiological consequences. Both social isolation and traumatic brain injury (TBI) alter normal brain function and structure. However, the influence of social isolation on recovery from TBI is unclear. This study aims to evaluate if social isolation exacerbates the anatomical and functional deficits after TBI in young rats. Juvenile male rats were divided into four groups; sham operated control with social contacts, sham control with social isolation, TBI with social contacts, and TBI with social isolation. During four weeks after brain injury in juvenile rats, we evaluated the animal behaviors by T-maze and open-field tests, recorded brain activity with electrocorticograms and assessed structural changes by histological procedures in the hippocampal dentate gyrus, CA1, and CA3 areas. Our findings revealed significant memory impairments and hyperactivity conditions in rats with TBI and social isolation compared to the other groups. Histological assessments showed an increase of the mean number of dark neurons, apoptotic cells, and caspase-3 positive cells in all tested areas of the hippocampus in TBI rats with and without social isolation compared to sham rats. Furthermore, social isolation significantly increased the number of dark cells, apoptotic neurons, and caspase-3 positive cells in the hippocampal CA3 region in rats with TBI. This study indicates the harmful effect of social isolation on anatomical and functional deficits induced by TBI in juvenile rats. Prevention of social isolation may improve the outcome of TBI.

Babak Khodaie; Ahmad Ali Lotfinia; Milad Ahmadi; Mahmoud Lotfinia; Maryam Jafarian; Fariba Karimzadeh; Philippe Coulon; Ali Gorji

2015-01-01T23:59:59.000Z

291

The harmful effects of late-onset alcohol consumption on cortical bone in aged rats  

E-Print Network [OSTI]

This study looked at the effects of late-onset alcohol consumption for 8 weeks on the aged rat model (15 months old). Thirty 15 month old female Fisher 344 rats were divided into three diet groups: Alcohol (n=9), pair-fed (n=9), and pellet (n=6...

Bowlin, Julie Lee

2012-06-07T23:59:59.000Z

292

Restraint stress exacerbates alcohol-induced reproductive toxicity in male rats  

Science Journals Connector (OSTI)

Abstract Cumulative exposure to multiple stresses may lead to aggravating the toxicity of each stress, qualitatively or quantitatively altering biological responses because of toxicological interaction. In this study, we intended to determine the possible effects of restraint stress on reproductive toxicity due to ethanol usage in male rats. Early pubertal male Wistar rats were subjected to either restraint stress (5h/day) or alcohol intoxication (2mg/kg body weight) or both for 60 days. Body weights of control and experimental rats were similar during the 60 days of this study. Testes were harvested, weighed, and prepared for enzyme assays, and cauda epididymides were isolated for the determination of density, motility, and viability of stored spermatozoa. Restraint stress or alcohol treatment significantly reduced testis weight and caused significant reductions in steroidogenesis and spermatogenesis. Mean density, motility, and viability of stored spermatozoa were reduced in experimental rats. Plasma testosterone concentrations in rats subjected to restraint stress or alcohol were decreased compared with those of controls, concomitant with increased concentrations of LH and FSH in experimental rats. These data suggest that sub-chronic exposure to restraint stress or alcohol contribute to reduce testicular and epididymal function in exposed rats. The study also suggests that restraint stress exacerbates alcohol-induced reproductive toxicity inrats.

P. Hari Priya; B.P. Girish; P. Sreenivasula Reddy

2014-01-01T23:59:59.000Z

293

Daptomycin plus fosfomycin: a synergistic combination in experimental implant-associated MRSA-osteomyelitis in rats  

Science Journals Connector (OSTI)

...in experimental implant-associated MRSA-osteomyelitis in rats T. Lingscheid 1 W. Poeppl 1 D. Bernitzky 1 Luzia Veletzky...Staphylococcus aureus (MRSA). Infection was induced in tibiae of rats by insertion of a bacterial inoculum (1-5108 CFU/ml) of...

T. Lingscheid; W. Poeppl; D. Bernitzky; Luzia Veletzky; Manuel Kussmann; R. Plasenzotti; H. Burgmann

2014-11-17T23:59:59.000Z

294

A connectionist model of spatial learning in the rat Thomas Strosslin  

E-Print Network [OSTI]

A connectionist model of spatial learning in the rat Thomas Str¨osslin April 14, 2004 #12. In subsequent visits, they can recall this information and thus avoid dangerous places or find again a food". In the late 1940s, theoretical considerations have led researchers to the conclusion that rats establish

Gerstner, Wulfram

295

Time of birth and daily activity mediated by feeding rhythms in the pregnant rat  

E-Print Network [OSTI]

Time of birth and daily activity mediated by feeding rhythms in the pregnant rat M. J. BOSC, Agnès studied in rats submitted to different feeding rhythms. Animals, put under 14 h of light and 10 h to one of five groups. Group C was fed ad libitum, and groups 2PF, 9PF, 14PF and 21 PF had food available

Boyer, Edmond

296

Behavioral/Systems/Cognitive Rat Orbitofrontal Cortex Separately Encodes Response and  

E-Print Network [OSTI]

Behavioral/Systems/Cognitive Rat Orbitofrontal Cortex Separately Encodes Response and Outcome units from rat lateral OFC during performance of a task in which the encoding of an expected rewarding the presence of neuronal correlates of rewards, such as foods or liq- uids, and of the sensory cues

Holland, Peter

297

RESEARCH ARTICLE Open Access Circadian signatures in rat liver: from gene  

E-Print Network [OSTI]

RESEARCH ARTICLE Open Access Circadian signatures in rat liver: from gene expression to pathways is entrained to environmental factors including light, food and stress. Transcriptional analyses of circadian performed pathway activity level analysis on a rich time series of transcriptional profiling in rat liver

Androulakis, Ioannis (Yannis)

298

Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes  

E-Print Network [OSTI]

Review Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 379 7.3. Positive emotionality: food intake and responsivity to psychostimulants: Received 2 May 2009 Received in revised form 12 August 2009 Accepted 13 August 2009 Keywords: Mouse Rat

Kalueff, Allan V.

299

A Heterogeneous Population Code for Elapsed Time in Rat Medial Agranular Cortex  

E-Print Network [OSTI]

A Heterogeneous Population Code for Elapsed Time in Rat Medial Agranular Cortex Matthew S. Matell of behavior are largely unknown. Here we recorded from medial agranular cortex neurons in rats while in estimating the time of food availability, robust responding typically bracketed the expected duration

Matell, Matthew S.

300

In the radial-arm maze (RAM; Olton & Samuelson, 1976), rats accurately discriminate between locations  

E-Print Network [OSTI]

In the radial-arm maze (RAM; Olton & Samuelson, 1976), rats accurately discriminate between the efficiency with which they deplete the small bits of food placed at the end of each maze arm prior to each containing the RAM. For example, Zoladek and Roberts (1978) showed that blinded rats performed at levels

Cook, Robert

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Quantitative Analysis of Peristaltic and Segmental Motion In Vivo in the Rat Small Intestine Using Dynamic  

E-Print Network [OSTI]

Quantitative Analysis of Peristaltic and Segmental Motion In Vivo in the Rat Small Intestine Using the utility of MRI to quan- titatively analyze these motions in the jejunum region of anes- thetized rats (N 6- and microscale mixing of the food chyme. Both peristaltic and segmental motions are essential for the absorption

Brasseur, James G.

302

Elevation of Plasma Tryptophan by Insulin in Rat By J. D. Fernstrom and R. J. Wurtman  

E-Print Network [OSTI]

Elevation of Plasma Tryptophan by Insulin in Rat By J. D. Fernstrom and R. J. Wurtman The concentration of tryptophan in rat doses of glucagon (1 mg/kg) reduce plasma increases by 30-40/0o 2 hr after in most foods8 and its unique role in several important physiologic functions. Tryptophan is a pre- cursor

Wurtman, Richard

303

The impact of binge drinking on the young growing female rat skeleton  

E-Print Network [OSTI]

, on the actively growing skeleton. The objective of this study was to determine whether or not binge drinking impacts the normal growth process of the young growing female rat skeleton. Twelve, four-week-old, female rats were paired to form an ethanol group and a...

Gallagher, Sharon Lee

2012-06-07T23:59:59.000Z

304

Effect of Transplantation of Human Fetal Tissues on Prooxidant-Antioxidant Equilibrium in the Liver and Blood Rats after Partial Hepatectomy in Rats  

Science Journals Connector (OSTI)

We studied the effect of transplantation of fetal liver cells and postnuclear cytoplasmic fraction from human fetal soft tissues on the prooxidant-antioxidant equilibrium in the liver and blood of rats after part...

V. I. Grishchenko; Yu. V. Nikitchenko

2001-10-01T23:59:59.000Z

305

Effect of ovariectomy on the proliferative capacity of intrahepatic rat cholangiocytes  

Science Journals Connector (OSTI)

Abstract Background & Aims: We evaluated the effects of ovariectomy (OVX) and estrogen replacement treatment on cholangiocyte proliferation induced by bile duct ligation (BDL). Methods: BDL (2 weeks) was performed in ovariectomized rats and the proliferative and apoptotic activity compared with normal, with BDL control rats, and with BDL OVX rats treated with 17-? estradiol. Results: OVX induced a significant (P nick-end labeling (TUNEL) and Fas positivity were markedly enhanced, indicating activation of Fas-mediated apoptosis. Administration of 17-? estradiol during BDL in OVX rats induced a normalization of bile duct mass, ER expression, cholangiocyte proliferation, and apoptosis (Fas and TUNEL) in comparison with untreated BDL rats. Conclusions: Our findings support the role of endogenous estrogens in sustaining the enhanced proliferative and secretory activities of cholangiocytes in cholestasis. On the basis of these data, the hypothesis of an estrogenic functional deficiency in chronic cholestatic liver diseases should merit careful attention. GASTROENTEROLOGY 2002;123:336-344

Domenico Alvaro; Alessandro Gigliozzi; Adolfo F. Attili; Paolo Onori; Antonio Franchitto; Antonella Vetuschi; Shannon Glaser; Gene Le Sage; Gianfranco Alpini; Sergio Morini; Eugenio Gaudio

2002-01-01T23:59:59.000Z

306

Absence of an Effect of Dietary Corn Oil Content on Plasma Prolactin, Progesterone, and 17?-Estradiol in Female Sprague-Dawley Rats  

Science Journals Connector (OSTI)

...of age, fed 5% com oil (3 rats: A; C; E) or 24% com oil (3 rats: B; D; F...the late- afternoon peak (Chart 3). Examination...cycle were found with peak concentra tions at proestrus...the rats fed 5% corn oil and 27% in the rats...

William C. Wetsel; Adrianne E. Rogers; Adrienne Rutledge; and Wendell W. Leavitt

1984-04-01T23:59:59.000Z

307

Male Wistar rats are more susceptible to lasting social anxiety than Wild-type Groningen rats following social defeat stress during adolescence  

Science Journals Connector (OSTI)

Adolescence is an important period for the development of adult social competences. Social stress during adolescence may contribute not only to an inadequate social development but also to adult vulnerability to social anxiety. There seems to be a clear individual differentiation, however, in the vulnerability to the long-term negative consequences of social stress. The current study further explores this individual vulnerability and is aimed at the influence of social stress during adolescence on adult social anxiety and its context specificity. Rats from different strains (Wistar and Wild-type Groningen rats) were exposed to the resident-intruder paradigm five times during 10min each in the period between postnatal day 45 and 58. Three and 7 weeks later, the animals were re-exposed to the context in the presence of either a dominant male or an anestrous female behind a wire mesh screen. Wistar rats that were socially defeated spent less time exploring the social stimulus in comparison with socially defeated Wild-type rats and their non-defeated controls. We conclude that the stressed Wistar rat shows signs of generalized social anxiety indicating that the Wistar rat can be considered as a vulnerable phenotype to effects of adolescent social stress.

Jose Vidal; Bauke Buwalda; Jaap M. Koolhaas

2011-01-01T23:59:59.000Z

308

Proteomic analysis of rat cerebral cortex following subchronic acrolein toxicity  

SciTech Connect (OSTI)

Acrolein, a member of reactive ?,?-unsaturated aldehydes, is a major environmental pollutant. Acrolein is also produced endogenously as a toxic by-product of lipid peroxidation. Because of high reactivity, acrolein may mediate oxidative damages to cells and tissues. It has been shown to be involved in a wide variety of pathological states including pulmonary, atherosclerosis and neurodegenerative diseases. In this study we employed proteomics approach to investigate the effects of subchronic oral exposures to 3 mg/kg of acrolein on protein expression profile in the brain of rats. Moreover effects of acrolein on malondialdehyde (MDA) levels and reduced glutathione (GSH) content were investigated. Our results revealed that treatment with acrolein changed levels of several proteins in diverse physiological process including energy metabolism, cell communication and transport, response to stimulus and metabolic process. Interestingly, several differentially over-expressed proteins, including ?-synuclein, enolase and calcineurin, are known to be associated with human neurodegenerative diseases. Changes in the levels of some proteins were confirmed by Western blot. Moreover, acrolein increases the level of MDA, as a lipid peroxidation biomarker and decreased GSH concentrations, as a non-enzyme antioxidant in the brain of acrolein treated rats. These findings suggested that acrolein induces the oxidative stress and lipid peroxidation in the brain, and so that may contribute to the pathophysiology of neurological disorders. - Highlights: Acrolein intoxication increased lipid peroxidation and deplete GSH in rat brain. Effect of acrolein on protein levels of cerebral cortex was analyzed by 2DE-PAGE. Levels of a number of proteins with different biological functions were increased.

Rashedinia, Marzieh; Lari, Parisa [Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad (Iran, Islamic Republic of); Abnous, Khalil, E-mail: Abnouskh@mums.ac.r [Pharmaceutical Research Center, Department of Medicinal Chemistry, Mashhad University of Medical Sciences, Mashhad (Iran, Islamic Republic of); Hosseinzadeh, Hossein, E-mail: Hosseinzadehh@mums.ac.ir [Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad (Iran, Islamic Republic of)

2013-10-01T23:59:59.000Z

309

Sodium alterations in isolated rat heart during cardioplegic arrest  

SciTech Connect (OSTI)

Triple-quantum-filtered (TQF) Na nuclear magnetic resonance (NMR) without chemical shift reagent is used to investigate Na derangement in isolated crystalloid perfused rat hearts during St. Thomas cardioplegic (CP) arrest. The extracellular Na contribution to the NMR TQF signal of a rat heart is found to be 73 {+-} 5%, as determined by wash-out experiments at different moments of ischemia and reperfusion. With the use of this contribution factor, the estimated intracellular Na ([Na{sup +}]{sub i}) TQF signal is 222 {+-} 13% of preischemic level after 40 min of CP arrest and 30 min of reperfusion, and the heart rate pressure product recovery is 71 {+-} 8%. These parameters are significantly better than for stop-flow ischemia: 340 {+-} 20% and 6 {+-} 3%, respectively. At 37{degrees}C, the initial delay of 15 min in [Na{sup +}]{sub i} growth occurs during CP arrest along with reduced growth later ({approximately}4.0%/min) in comparison with stop-flow ischemia ({approximately}6.7%/min). The hypothermia (21{degrees}C, 40 min) for the stop-flow ischemia and CP dramatically decreases the [Na{sup +}]{sub i} gain with the highest heart recovery for CP ({approximately}100%). These studies confirm the enhanced sensitivity of TQF NMR to [Na{sup +}]{sub i} and demonstrate the potential of NMR without chemical shift reagent to monitor [Na{sup +}]{sub i} derangements. 48 refs., 7 figs., 1 tab.

Schepkin, V.D.; Choy, I.O.; Budinger, T.F. [Lawrence Berkeley National Lab., CA (United States)

1996-12-01T23:59:59.000Z

310

Developmental effects of inhalation exposure to 2-bromopropane in rats  

Science Journals Connector (OSTI)

2-Bromopropane (2-BP), known as a reproductive and hematopoietic toxicant in humans, was assessed for developmental toxicity. SpragueDawley rats were exposed by inhalation to 2-BP at a concentration of 0 (control), 125, 250, 500, or 1000ppm for 6h per day, 7 days per week during 2 weeks of the pre-mating period, during the mating period until copulation and during the period of gestation days 019. After parturition, dams were allowed to breast feed their pups until postnatal day 4. 2-BP exposure resulted in no signs of maternal toxicity as assessed by clinical observations and body weight gain. On the other hand, the inhalation exposure to 1000ppm markedly decreased the number of pups born, although the number of implantations did not decrease. No effect of 2-BP on pups weights or survival until postnatal day 4 was found. It was found that the repeated inhalation exposure of rats to 1000ppm 2-BP induced fetal lethality during the post-implantation period.

Tetsuya Takeuchi; Hirokazu Okuda; Heihachiro Arito; Kasuke Nagano; Seigo Yamamoto; Taijiro Matsushima

2004-01-01T23:59:59.000Z

311

Ozone induces glucose intolerance and systemic metabolic effects in young and aged brown Norway rats  

SciTech Connect (OSTI)

Air pollutants have been associated with increased diabetes in humans. We hypothesized that ozone would impair glucose homeostasis by altering insulin signaling and/or endoplasmic reticular (ER) stress in young and aged rats. One, 4, 12, and 24 month old Brown Norway (BN) rats were exposed to air or ozone, 0.25 or 1.0 ppm, 6 h/day for 2 days (acute) or 2 d/week for 13 weeks (subchronic). Additionally, 4 month old rats were exposed to air or 1.0 ppm ozone, 6 h/day for 1 or 2 days (time-course). Glucose tolerance tests (GTT) were performed immediately after exposure. Serum and tissue biomarkers were analyzed 18 h after final ozone for acute and subchronic studies, and immediately after each day of exposure in the time-course study. Age-related glucose intolerance and increases in metabolic biomarkers were apparent at baseline. Acute ozone caused hyperglycemia and glucose intolerance in rats of all ages. Ozone-induced glucose intolerance was reduced in rats exposed for 13 weeks. Acute, but not subchronic ozone increased ?{sub 2}-macroglobulin, adiponectin and osteopontin. Time-course analysis indicated glucose intolerance at days 1 and 2 (2 > 1), and a recovery 18 h post ozone. Leptin increased day 1 and epinephrine at all times after ozone. Ozone tended to decrease phosphorylated insulin receptor substrate-1 in liver and adipose tissues. ER stress appeared to be the consequence of ozone induced acute metabolic impairment since transcriptional markers of ER stress increased only after 2 days of ozone. In conclusion, acute ozone exposure induces marked systemic metabolic impairments in BN rats of all ages, likely through sympathetic stimulation. - Highlights: Air pollutants have been associated with increased diabetes in humans. Acute ozone exposure produces profound metabolic alterations in rats. Age influences metabolic risk factors in aging BN rats. Acute metabolic effects are reversible and repeated exposure reduces these effects. Ozone metabolic effects are only slightly exacerbated in geriatric rats.

Bass, V. [Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Gordon, C.J.; Jarema, K.A.; MacPhail, R.C. [Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Cascio, W.E. [Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Phillips, P.M. [Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Ledbetter, A.D.; Schladweiler, M.C. [Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Andrews, D. [Research Cores Unit, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Miller, D. [Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC (United States); Doerfler, D.L. [Research Cores Unit, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Kodavanti, U.P., E-mail: kodavanti.urmila@epa.gov [Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States)

2013-12-15T23:59:59.000Z

312

09/08/2006 06:18 PMLocal News Updates -Rats can teach humans something about jetlag -The Boston Globe Page 1 of 2http://www.boston.com/news/globe/city_region/breaking_news/2006/09/rats_can_teach.html  

E-Print Network [OSTI]

09/08/2006 06:18 PMLocal News Updates - Rats can teach humans something about jetlag -The Boston Globe Page 1 of 2http://www.boston.com/news/globe/city_region/breaking_news/2006/09/rats, September 7, 2006 Rats can teach humans something about jetlag By Andrew Ryan, Globe Correspondent Rats

Siegelmann , Hava T

313

Effects of Pyrimidine Nucleoside Phosphorylase Inhibitors on Hepatic Fluoropyrimidine Elimination in the Rat  

Science Journals Connector (OSTI)

...Louis, MO). Ion-exchange resins were obtained...min before the addition of the fluoropyrimidine...sequential cation-exchange and anion- exchange...rat liver. The demonstration that 2,4-DHP...Separation by ion exchange chromatography...

Frank P. LaCreta; Barbour S. Warren; and Walter M. Williams

1989-05-15T23:59:59.000Z

314

Regulation of Endothelial Phenotype in Rat Soleus Muscle Feed Arteries: Influence of Aging and Exercise Training  

E-Print Network [OSTI]

oxide (NO) pathway in the skeletal muscle vasculature. The major purpose of this dissertation is to determine the mechanisms that mediate age-related endothelial dysfunction in rat soleus feed artery (SFA) and determine whether exercise training...

Trott, Daniel Wayne

2012-02-14T23:59:59.000Z

315

Ontogenesis of alpha-amylase in rat parotid gland during postnatal development  

Science Journals Connector (OSTI)

Changes in ?-amylase (?-1,4-glucan-4-glucanohydrolase, EC 3.2.1.1) of parotid gland were investigated during postnatal development of the rat. Modifications in amylase activity after birth allow the distinctio...

S. L. Bellavia; E. G. Sanz; N. T. Vermouth; L. Rins; A. Aoki

1981-01-01T23:59:59.000Z

316

Effect of sexual steroids upon ontogeny of alpha-amylase of rat parotid gland  

Science Journals Connector (OSTI)

The effect of gonadectomy (at the 10th day of life) and treatment with sexual steroids (during the first month) upon development of alpha-amylase activity in rat parotid gland has been...

S. L. Bellavia; E. G. Sanz; N. T. Vermouth

1982-04-01T23:59:59.000Z

317

Alpha-amylase inhibitor increases plasma 3-hydroxybutyric acid in food-restricted rats  

Science Journals Connector (OSTI)

The effect on energy metabolism of delayed absorption of starch by inhibition of ?-amylase was examined by considering levels of plasma glucose and 3-hydroxybutyric acid (3-OHBA) in rats. Addition of ?-amylase...

T. Doi; H. Yoshimatsu; I. Katsuragi; M. Kurokawa; H. Takahashi; A. Motoshio

1995-06-14T23:59:59.000Z

318

Use of Sulphonamides in the Treatment of Pleuro-pneumonia-like Organisms in Rats  

Science Journals Connector (OSTI)

... passages. This is followed by anorexia and gradual loss of weight. The hair becomes roughened and the rat takes on the typical appearance of a sick animal. In the ...

R. T. CHARLES; O. REES

1958-04-26T23:59:59.000Z

319

Impact of Ghrelin Receptor Antagonism on Nicotine and Cocaine Drug Reactivity in Rats  

E-Print Network [OSTI]

than do rats that were repeatedly exposed to vehicle. This could be indicative of how ghrelin is known to reorganize inputs in the reward pathway particularly in the VTA, to result in neural activation (sensitization) (Abizaid et al., 2006b...

Clifford, Patrick Shane

2013-05-01T23:59:59.000Z

320

Obstructive Jaundice in Rats: Cause of Spatial Memory Deficits with Recovery after Biliary Decompression  

Science Journals Connector (OSTI)

Children with end-stage liver disease have been found to have cognitive deficits. The aim of this study was to examine whether cholestatic jaundice causes spatial deficits in rats and if these cognitive defici...

Li-Tung Huang M.D.; Chih-Sung Hsieh M.D.; Ming-Huei Chou M.D.

2004-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

E-Print Network 3.0 - albino rat anatomical Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

E-Mail karger@karger.ch Summary: Prc3 Oc 1 Caviness 1975 Mouse - C57 40 3 1 3a 46 2 17 18a 41 22 Zilles et al.1980 Albino rat... organization, function, development, and...

322

E-Print Network 3.0 - albino rats exposed Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

E-Mail karger@karger.ch Summary: Prc3 Oc 1 Caviness 1975 Mouse - C57 40 3 1 3a 46 2 17 18a 41 22 Zilles et al.1980 Albino rat... organization, function, development, and...

323

The effect of food restriction and simulated microgravity on the rat skeleton  

E-Print Network [OSTI]

on the skeleton. This food deficit combined with microgravity could create an additive loss of bone for astronauts. Forty eight Sprague-Dawley adult male rats were subjected to hindlimb suspension (HLS), to simulate the weightless environment of outer space...

Currado, Alicia Anne

2012-06-07T23:59:59.000Z

324

Acquisition of cocaine and heroin self-administration in rats developmentally exposed to lead  

E-Print Network [OSTI]

, female rats were gavaged daily with 0 or 16 mg lead for 30 days prior to breeding with nonexposed males. Metal administration continued through pregnancy and lactation and was discontinued at weaning (postnatal day [PND] 21). Animals born to control...

Rocha, Angelica

2005-08-29T23:59:59.000Z

325

Characterizing strain in the proximal rat tibia during electrical muscle stimulation  

E-Print Network [OSTI]

electrical muscle stimulation as an exercise countermeasure for hindlimb unloading in rats. A mathematical relationship between strain and torque was established for the exercise during a 28 day period of hindlimb unloading. The strain generated during...

Vyvial, Brent Aron

2007-09-17T23:59:59.000Z

326

Cocaine hypophagia and hyperlocomotion in rats before and after exposure to a high-fat diet  

E-Print Network [OSTI]

Relatively few studies have examined the effects of psychostimulants in obese subjects. Using the dietary obese rat model, the present experiments determined the reductions in food intake (hypophagia) and increases in locomotion (hyperlocomotion...

Ho, Dao Hong

2005-02-17T23:59:59.000Z

327

Beneficial effects of dietary L-arginine supplementation to diabetic rats  

E-Print Network [OSTI]

Diabetic rats exhibit decrease in plasma arginine, NO synthesis and tetrahydrobiopterin in endothelial cells (EC). Treatment with L-arginine may be beneficial for enhancing NO synthesis in diseases associated with endothelial dysfunction. However...

Kohli, Ripla

2004-09-30T23:59:59.000Z

328

E-Print Network 3.0 - adult rats spinalized Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Search Sample search results for: adult rats spinalized Page: << < 1 2 3 4 5 > >> 1 Brain Research 918 (2001) 101106 www.elsevier.comlocatebres Summary: play a minor role in...

329

E-Print Network 3.0 - adult rat spinal Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Advanced Search Sample search results for: adult rat spinal Page: << < 1 2 3 4 5 > >> 1 Brain Research 918 (2001) 101106 www.elsevier.comlocatebres Summary: play a minor role in...

330

E-Print Network 3.0 - adult wistar rats Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

(C3H RIII)F1... 344Tox fdr FDRL fds Food and Drug Research Laboratories stock rats fis Fischer fmf Fischer 344Mai f... :(LE) lee Leeds albino lev Long-Evans lew Lewis lwj...

331

E-Print Network 3.0 - albinus rat wistar Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

(C3H RIII)F1... 344Tox fdr FDRL fds Food and Drug Research Laboratories stock rats fis Fischer fmf Fischer 344Mai f... :(LE) lee Leeds albino lev Long-Evans lew Lewis lwj...

332

E-Print Network 3.0 - adult rat heart Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

heart Search Powered by Explorit Topic List Advanced Search Sample search results for: adult rat heart Page: << < 1 2 3 4 5 > >> 1 doi:10.1152ajpheart.00114.2006 291:496-506,...

333

E-Print Network 3.0 - acetate-salt hypertensive rats Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

hypertensive rats Page: << < 1 2 3 4 5 > >> 1 ISSN: 1524-4563 Copyright 2005 American Heart Association. All rights reserved. Print ISSN: 0194-911X. Online Summary: hypertensive...

334

Effects of depleted uranium after short-term exposure on vitamin D metabolism in rat  

Science Journals Connector (OSTI)

Uranium is a natural radioactive heavy metal. Its ... brain. Effects of an acute contamination by depleted uranium (DU) were investigated in vivo on...3 biosynthetic pathway. Rats received an intragastric adminis...

E. Tissandie; Y. Guguen; J. M. A. Lobaccaro; F. Paquet

2006-08-01T23:59:59.000Z

335

Clinical diagnostic indicators of renal and bone damage in rats intramuscularly injected with depleted uranium  

Science Journals Connector (OSTI)

......intramuscularly injected with depleted uranium S. Fukuda 1 M. Ikeda 1 M...related to kidney and bone in depleted uranium (DU)-injected rats were...injected is low. INTRODUCTION Depleted uranium (DU) accumulates like natural......

S. Fukuda; M. Ikeda; M. Chiba; K. Kaneko

2006-06-01T23:59:59.000Z

336

E-Print Network 3.0 - anesthetized lactating rats Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in situ and force in the rat plantaris muscle during repeated Effect of lactate infusion on M... .physiology.orgDownloadedfrom 12;Effect of lactate infusion on M-wave...

337

Evaluation of HIV-1 Tat induced neurotoxicity in rat cortical cell culture  

Science Journals Connector (OSTI)

In a substantial number of cases, Human Immunodeficiency Virus type 1 (HIV-1) infection causes neuronal cell loss and ... loss. Here we studied the effect of HIV-1 Tat in primary rat neuronal cells as a ... cell ...

Aleida Prez; Albert W. Probert; Kevin K. W. Wang

2001-01-01T23:59:59.000Z

338

Rat Lung Macrophage Tumor Cytotoxin Production: Impairment by Chronic in Vivo Cigarette Smoke Exposure  

Science Journals Connector (OSTI)

...macrophage cytotoxin production and investigated...MATERIALS AND METHODS Animals. Experimental...nonsmokers. Our method measures cytotoxin production from large populations...not restore the production to control levels...24, 33), hydrogen peroxide in rats...

David A. Flick; Ricardo J. Gonzalez-Rothi; J. Ocie Harris; and George E. Gifford

1985-11-01T23:59:59.000Z

339

E-Print Network 3.0 - adult rat testis Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

5, 8492 2000 Journals of Reproduction and Fertility Summary: in blood (Table 1). In rats, the concentration of oestradiol in rete testis fluid is approximately 250 pg... in the...

340

E-Print Network 3.0 - acid-deficient hairless rat Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

G. Galef6 7 8 9 Department of Psychology... of smell.48 49 Synopsis50 12;3 Norway rats served for many decades as the main subject species... of research papers were52...

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Antihyperglycemic and antihyperlipidemic properties of aqueous root extract of Icacina senegalensis in alloxan induced diabetic rats  

Science Journals Connector (OSTI)

AbstractObjective To evaluate the antidiabetic and hypolipidemic activity of aqueous root extract of Icacina senegalensis (I. senegalensis) in alloxan-induced diabetic rats. Method Blood glucose levels of alloxan-induced diabetic rats were monitored after the administration of I. senegalensis extract (100, 200 and 400 mg/kg) to diabetic rats for 14 d. Different biochemical parameters, serum cholesterol, serum triglyceride, high density lipoprotein, low density lipoprotein and very low density lipoprotein were also examined. Results Treatment of alloxan diabetic rats with the extract showed significant (P<0.05) activity. The activity of the extract was comparable to that of the standard drug, glinbeclamide. Conclusions The results suggest that the root extract of I. senegalensis possesses antidiabetic and hypolipidemic properties, which might be a potential source for isolation of new orally active agent in the treatment of diabetes and its associated complications.

GC Akuodor; PM Udia; A Bassey; KC Chilaka; OA Okezie

2014-01-01T23:59:59.000Z

342

Toward whole-body optical imaging of rats using single-photon counting fluorescence tomography  

Science Journals Connector (OSTI)

We used single-photon counting (SPC) detection for diffuse fluorescence tomography to image nanomolar (nM) concentrations of reporter dyes through a rat. Detailed phantom data are...

Leblond, Frederic; Tichauer, Kenneth M; Holt, Robert W; El-Ghussein, Fadi; Pogue, Brian W

2011-01-01T23:59:59.000Z

343

Impact of Ghrelin and Cocaine on Intracranial Self-Stimulation in Rats  

E-Print Network [OSTI]

pairing of both on rate-frequency curves, maximal response rate, and threshold (the frequency that produces 50% of the maximal response rate) obtained during intracranial self-stimulation (ICSS) of the medial forebrain bundle (MFB). In this task, rats...

Kniffin, Tracey C

2012-07-11T23:59:59.000Z

344

The effect of Zoledronate treatment timing on lumbar and caudal vertebrae in ovariectomized rats  

E-Print Network [OSTI]

Introduction: While there have been numerous studies demonstrating the effect of bisphosphonates in rats as either a preventative treatment or recovering treatment for osteoporosis, few have directly compared the two ...

Ruchelsman, Michal (Michal Aliza)

2007-01-01T23:59:59.000Z

345

E-Print Network 3.0 - adult rat somatosensory Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Stimulus-driven response dynamics of the whiskerbarrel-cortex system in awake behaving rats Summary: the barrel region of primary somatosensory cortex in adult female Long-Evans...

346

E-Print Network 3.0 - adult rat optic Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the Summary: ; Hill et al., 1986; Hill and Przekop, 1988; Ye et al., 1993). Thus, adult rats that have been... ganglion neurons that innervate a single taste bud (Krimm and Hill,...

347

Two new species of Gliricola (Phthiraptera: Gyropidae) from the spiny tree rat, Mesomys hispidus, in Peru.  

E-Print Network [OSTI]

Two new species of Gliricola, G. woodmani and G. halli (Phthiraptera: Gyropidae), are described and illustrated for specimens from the spiny tree rat, Mesomys hispidus (Rodentia: Echimyidae), in Peru. Resumen--Se ...

Price, Roger D.; Timm, Robert M.

1993-06-01T23:59:59.000Z

348

The energy costs of sexual dimorphism in mole-rats are morphological not behavioural  

Science Journals Connector (OSTI)

...January 2006 research-article The energy costs of sexual dimorphism in mole-rats...mammals have directly compared the energy costs of reproductive activities between...sexes for either species. The energy cost of dimorphism is most likely to...

2006-01-01T23:59:59.000Z

349

Excitation of Rat Cerebellar Golgi Cells by Ethanol: Further Characterization of the Mechanism  

E-Print Network [OSTI]

Excitation of Rat Cerebellar Golgi Cells by Ethanol: Further Characterization of the Mechanism Background: Studies with rodents suggest that acute ethanol exposure impairs information flow through of action of ethanol. Methods: Computer modeling techniques and patch-clamp electrophysiological recordings

De Schutter, Erik

350

Tyrosine Transaminase: Development of Daily Rhythm in Liver of Neonatal Rat  

Science Journals Connector (OSTI)

...Present address: U.S. Geological Survey, Water Resources Division, Tallahassee, Flor-ida 32304. 18 September 1968 Female CFE rats (Carworth) were obtained during the second week of pregnancy. During gestation and at all times thereafter, the animals...

Eva Honova; Sanford A. Miller; Richard A. Ehrenkranz; Anna Woo

1968-11-29T23:59:59.000Z

351

Immunity to Viral Leukemia in Rats and the Routes of Transmission from Mother to Offspring  

Science Journals Connector (OSTI)

...Leukemia in Rats and the Routes of Transmission from Mother to Offspring1...vitro, and (c) the routes by which anti-GLV...tissue culture cell line G, which replicates...pre- and postnatal routes of transmission, quantitative experiments...

Harry L. Ioachim; Steven E. Keller; Martin L. Gimovsky; and Sue Shepherd

1973-03-01T23:59:59.000Z

352

E-Print Network 3.0 - adult rat sacral Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

capensis) from Cape Town. Used with the permission of the pho... . Georychus capensis (Pallas, 1778) Cape Mole-rat Mus capensis Pallas, 1778:172. Type locality ... Source: Hayssen,...

353

Characterization of biliary conjugates of 4,4'-methylenedianiline in male versus female rats  

SciTech Connect (OSTI)

4,4'-Methylenedianiline (4,4'-diaminodiphenylmethane; DAPM) is an aromatic diamine used in the production of numerous polyurethane foams and epoxy resins. Previous studies in rats revealed that DAPM initially injures biliary epithelial cells of the liver, that the toxicity is greater in female than in male rats, and that the toxic metabolites of DAPM are excreted into bile. Since male and female rats exhibit differences in the expression of both phase I and phase II enzymes, our hypothesis was that female rats either metabolize DAPM to more toxic metabolites or have a decreased capacity to conjugate metabolites to less toxic intermediates. Our objective was thus to isolate, characterize, and quantify DAPM metabolites excreted into bile in both male and female bile duct-cannulated Sprague Dawley rats. The rats were gavaged with [{sup 14}C]-DAPM, and the collected bile was subjected to reversed-phase HPLC with radioisotope detection. Peaks eluting from HPLC were collected and analyzed using electrospray MS and NMR spectroscopy. HPLC analysis indicated numerous metabolites in both sexes, but male rats excreted greater amounts of glutathione and glucuronide conjugates than females. Electrospray MS and NMR spectra of HPLC fractions revealed that the most prominent metabolite found in bile of both sexes was a glutathione conjugate of an imine metabolite of a 4'-nitroso-DAPM. Seven other metabolites were identified, including acetylated, cysteinyl-glycine, glutamyl-cysteine, glycine, and glucuronide conjugates. While our prior studies demonstrated increased covalent binding of DAPM in the liver and bile of female compared to male rats, in these studies, SDS-PAGE with autoradiography revealed 4-5 radiolabeled protein bands in the bile of rats treated with [{sup 14}C]-DAPM. In addition, these bands were much more prominent in female than in male rats. These studies thus suggest that a plausible mechanism for the increased sensitivity of female rats to DAPM toxicity may be decreased conjugation of reactive DAPM metabolites, leading to greater levels of protein adduct formation.

Chen, Kan; Cole, Richard B. [Department of Chemistry, University of New Orleans, New Orleans, LA (United States); Santa Cruz, Vicente [Department of Pathology, University of Texas Medical Branch, Galveston, TX (United States); Blakeney, Ernest W. [Department of Chemistry, Centenary College, Shreveport, LA (United States); Kanz, Mary F. [Department of Pathology, University of Texas Medical Branch, Galveston, TX (United States); Dugas, Tammy R. [Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center-Shreveport, 1501 Kings Highway, Shreveport, LA 71130 (United States)], E-mail: tdugas@lsuhsc.edu

2008-10-15T23:59:59.000Z

354

Effect of dietary cysteine, methionine, and sterculic acid on fatty acid distribution in rat adipose tissue  

E-Print Network [OSTI]

EFFECT OF DIETARY CYSTEINE, MFTHIONINE, AND STERCULIC ACID ON FATTY ACID DISTRIBUTION IN RAT ADIPOSE TISSUE A Thesis By MARY FRANCES BROTZE Submitted to the Graduate College of the Texas A(M University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE January 1968 Major Subject: BIOCHEMISTRY EFFECT OF DIETARY CYSTEINE, METHIONINE, AND STERCULIC ACID ON FATTY ACID DISTRIBUTION IN RAT ADIPOSE TISSUE A Thesis MAaY FRANCES BRC ~ '!E Approved as to style...

Brotze, Mary Frances

2012-06-07T23:59:59.000Z

355

The effects of radiation on spermatogenesis in the albino rat as determined by semen analysis  

E-Print Network [OSTI]

rate all could be significant factors. Total body X-irradiation (470 r) in rats produced minimal alterations in the testes, namely depletion of spermatogonia (Gunn, et al. , 1960). 17 18 The effect of whole-body radiation on fertility of male rats...) Figure 22. Effect of Radiation on Weight Change (Chronic). no irradiation, demonstrated steady weekly increases through the investigation period. The average body weight of these animals at the initiation of this study was approximately 510 grams...

Lawson, Rommon Loy

1964-01-01T23:59:59.000Z

356

Systematics of the southern races of two species of kangaroo rats (Dipodomys compactus and D. ordi)  

E-Print Network [OSTI]

SYSTEMATICS OF THE SOUTHERN RACES OF TWO SPECIES OF KANGAROO RATS (DIPODOMYS COMPACTUS AND D. ORDI) A Thesis by GEORGE DAVIS BAUMGARDNER Submitted to the Graduate Colleqe of Texas A&M University in partial fulfillment o- the requirement... for the deqree of MASTER OF SCIENCE May 1979 Major Subject: Nildlife and Fisheries Sciences SYSTEMATICS OF THE SOUTHERN RACES OF TWO SPECIES OF KANGAROO RATS (DIPODOMYS COMPACTUS AND D. ORDI) A Thesis by GEORGE DAVIS BAUMGARDNER Approved as to style...

Baumgardner, George D

2012-06-07T23:59:59.000Z

357

Effect of exercise training and dietary fat on rat adipose tissue lipolysis and morphology  

E-Print Network [OSTI]

EFFECT OF EXERCISE TRAINING AND DIETARY FAT ON RAT ADIPOSE TISSUE LIPOLYSIS AND MORPHOLOGY A Thesis by SONIA BARSTAD NEALZ Submitted to the Office of Graduate Studies of Texas ASM University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE May 1989 Major Subject: Nutrition EFFECT OF EXERCISE TRAINING AND DIETARY FAT ON RAT ADIPOSE TISSUE LIPOLYSIS AND MORPHOLOGY A Thesis by SONIA BARSTAD NEALE Approved as to style and content by: Karen S. Kubena (Co...

Neale, Sonia Barstad

2012-06-07T23:59:59.000Z

358

Copper induced osteopenia and its relationship to the development of postmenopausal osteoporosis in the rat  

E-Print Network [OSTI]

COPPER INDUCED OSTEOPENIA AND ITS RELATIONSHIP TO THE DEVELOPMENT OF POSTMENOPAUSAL OSTEOPOROSIS IN THE RAT A Thesis CINDY DEANN YEE Submitted to the Office of Graduate Studies of Texas ASM University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE August 1992 Major Subject: Nutrition COPPER INDUCED OSTEOPENIA AND ITS RELATIONSHIP TO THE DEVELOPMENT OF POSTMENOPAUSAL OSTEOPOROSIS IN THE RAT A Thesis CINDY DEANN YEE Approved as to style and content...

Yee, Cindy Deann

2012-06-07T23:59:59.000Z

359

The effects of chronic dietary cobalt exposure on behavior and metallothionein levels in the adult rat  

E-Print Network [OSTI]

THE EFFECTS OF CHRONIC DIETARY COBALT EXPOSURE ON BEH'AVIOR AND METALLOTHIONEIN LEVELS IN THE ADULT RAT A Thesis by MICHAEL FRANCIS HARE Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement... for the degree of MASTER OF SCIENCE December 198$ Major Subject: Psychology THE EFFECTS OF CHRONIC DIETARY COBALT EXPOSURE ON BEHAVIOR AND METALLOTHIONEIN LEVELS IN THE ADULT RAT A Thesis by MICHAEL FRANCIS HARE Approved as to style and content by...

Hare, Michael Francis

2012-06-07T23:59:59.000Z

360

The effects of dietary phenylalanine supplementation on ochratoxicosis in normal and partially nephrectomized rats  

E-Print Network [OSTI]

THE EFFECTS OF DIETARY PHENYLALANINE SUPPLEMENTATION ON OCHRATOXICOSIS IN NORMAL AND PARTIALLY NEPHRECTOMIZED RATS A Thesis By RUGER WILLIAM PARKER Submitted to the Graduate College of Texas AKM University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE December lg83 Magor SubJect: Epidemiology THE EFFECTS OF DIETARY PHENYLALANINE SUPPLEMENTATION ON OCHRATOXICOSIS IN NORMAL AND PARTIALLY NEPHRECTOMIZEU RATS A Thesis by ROGER WILLIAM PARKER Approved...

Parker, Roger William

2012-06-07T23:59:59.000Z

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

3-Methylhistidine excretion as an index of dietary protein adequacy in the rat  

E-Print Network [OSTI]

3-METHYLHISTIDINE EXCRETION AS AN INDEX OF DIETARY PROTEIiV ADEQUACY IN THE RAT A Thesis by REBECCA KAY KIRBY Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement for the degree of MASTER... OF SCIENCE August 1980 Major Subject: Biochemistry and Biophysics 3-METHYLHISTIDINE EXCRETION AS AN INDEX OF DIETARY PROTEIN ADEQUACY IN THE RAT A Thesis by REBECCA KAY KIRBY Approved as to style and content by: (Chairman of Committee) (Member...

Kirby, Rebecca Kay

2012-06-07T23:59:59.000Z

362

The effect of stress on the pulsatile pattern of luteinizing hormone in the ovariectomized rat  

E-Print Network [OSTI]

THE EFFECT OF STRESS ON THE PULSATILE PATTERN OF LUTEINIZING HORMONE IN THE OVARIECTOMIZEO RAT A Thesis by KATHRYN LOUISE FARR Submitted to the Graduate College of Texas ASM University in partial fulfillment of the requirement for the degree... of MASTER OF SCIENCE August 1982 Major Subject: Physiology of Reproduction THE EFFECT OF STRESS ON THE PULSATILE PATTERN OF LUTEINIZING HORMONE IN THE OVARIECTOMIZEO RAT A Thesis by KATHRYN LOUISE FARR Approved as to style and content by: Chairman...

Farr, Kathryn Louise

2012-06-07T23:59:59.000Z

363

The quantification of oxygen toxicity by the technique of cellulose acetate electrophoresis of rat serum proteins  

E-Print Network [OSTI]

THE QUANTIFICATION OF OXYGEN TOXICITY BY THE TECHNIQUE OF CELLULOSE ACETATE ELECTROPHORESIS OF RAT SERUM PROTEINS A Thesis by MARCIA WAGNER BARKER Submitted to the Graduate College of Texas A&ii University in partial fulfillment... of the requirement for the degree of MASTER OF SCIENCE December 1979 Major Subject: Biology THE QUANTIFICATION OF OXYGEN TOXICITY BY THE TECHNIQUE OF CELLULOSE ACETATE ELECTROPHORESIS OF RAT SERUM PROTEINS A Thesis by MARCIA WAGNER BARKER Approved...

Barker, Marcia Wagner

2012-06-07T23:59:59.000Z

364

Magnesium and pyridoxine intake and mineral content of selected tissues and physical development in rats  

E-Print Network [OSTI]

MAGNESIUM AND PYRIDOXINE INTAKE MINERAL CONTENT OF SELECTED TISSUES PHYSICAL DEVELOPMENT IN RATS A Thesis by SU S AN ELA I NE EDGAR Submitted to the Graduate College of Texas A8rM University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE August 1986 Major Subject: Nutrition MAGNESIUM AND PYRIDOXINE INTAKE MINERAL CONTENT OF SELECTED TISSUES PHYS ICAL DEVELOPMENT IN RATS A Thesis by SUSAN ELAINE EDGAR Approved as to style and content by: 'KAREN...

Edgar, Susan Elaine

2012-06-07T23:59:59.000Z

365

Metabonomic Study of Chinese Medicine Shuanglong Formula as an Effective Treatment for Myocardial Infarction in Rats  

Science Journals Connector (OSTI)

A metabonomics-based approach is presented to assess the holistic efficacy of Shuanglong Formula (SLF) for myocardial infarction (MI) in rats. ... The metabonomic results correlating to biochemical and histopathological assay revealed that the bitherapy SLF exerted synergistic therapeutic efficacies to exhibit a better effect on MI compared to Panax ginseng (PG) or Salvia miltiorrhiza (SM). ... A UPLC/TOF-MS-based metabonomic study was conducted to assess the holistic efficacy of Traditional Chinese Medicine Shuanglong Formula (SLF) for myocardial infarction in rats. ...

Xiaoping Liang; Xi Chen; Qionglin Liang; Hongyang Zhang; Ping Hu; Yiming Wang; Guoan Luo

2010-11-22T23:59:59.000Z

366

Sodium and potassium levels in the serum of acutely irradiated and non-irradiated rats  

E-Print Network [OSTI]

SODIUM AND POTASSIUM LEVELS IN THE SERUM OF ACUTELY IRRADIATED AND NON-IRRADIATED RATS A Thesis By DAVID PRESTON SHEPHERD Submitted to the Graduate College of the Texas ARM University in partial fulfillment of the requirements for the degree... of MASTER OF SCIENCE August 1967 Major Subject: Zoology SODIUM AND POTASSIUM LEVELS IN THE SERUM OF ACUTELY IRRADIATED AND NON-IRRADIATED RATS A Thesis By DAVID PRESTON SHEPHERD Approved as to style and content by: (Chairman of Committee) (Head...

Shepherd, David Preston

2012-06-07T23:59:59.000Z

367

Mycophenolate mofetil attenuates pulmonary arterial hypertension in rats  

SciTech Connect (OSTI)

Pulmonary arterial hypertension (PAH) is characterized by abnormal proliferation of smooth muscle cells (SMCs), leading to occlusion of pulmonary arterioles, right ventricular (RV) hypertrophy, and death. We investigated whether mycophenolate mofetil (MMF), a potent immunosuppresssant, prevents the development of monocrotaline (MCT)-induced PAH in rats. MMF effectively decreased RV systolic pressure and RV hypertrophy, and reduced the medial thickness of pulmonary arteries. MMF significantly inhibited the number of proliferating cell nuclear antigen (PCNA)-positive cells, infiltration of macrophages, and expression of P-selectin and interleukin-6 on the endothelium of pulmonary arteries. The infiltration of T cells and mast cells was not affected by MMF. In vitro experiments revealed that mycophenolic acid (MPA), an active metabolite of MMF, dose-dependently inhibited proliferation of human pulmonary arterial SMCs. MMF attenuated the development of PAH through its anti-inflammatory and anti-proliferative properties. These findings provide new insight into the potential role of immunosuppressants in the treatment of PAH.

Suzuki, Chihiro [Division of Cardiovascular Sciences, Department of Organ Regeneration, Shinshu University Graduate School of Medicine, Matsumoto (Japan); Takahashi, Masafumi [Division of Cardiovascular Sciences, Department of Organ Regeneration, Shinshu University Graduate School of Medicine, Matsumoto (Japan)]. E-mail: masafumi@sch.md.shinshu-u.ac.jp; Morimoto, Hajime [Division of Cardiovascular Sciences, Department of Organ Regeneration, Shinshu University Graduate School of Medicine, Matsumoto (Japan); Izawa, Atsushi [Division of Cardiovascular Sciences, Department of Organ Regeneration, Shinshu University Graduate School of Medicine, Matsumoto (Japan); Ise, Hirohiko [Division of Cardiovascular Sciences, Department of Organ Regeneration, Shinshu University Graduate School of Medicine, Matsumoto (Japan); Hongo, Minoru [Department of Cardiovascular Medicine, Shinshu University School of Health Sciences, Matsumoto (Japan); Hoshikawa, Yasushi [Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai (Japan); Ito, Takayuki [Department of Cardiovascular Medicine, Jichi Medical School, Tochigi (Japan); Miyashita, Hiroshi [Department of Cardiovascular Medicine, Jichi Medical School, Tochigi (Japan); Kobayashi, Eiji [Division of Organ Replacement Research, Jichi Medical School, Tochigi (Japan); Shimada, Kazuyuki [Department of Cardiovascular Medicine, Jichi Medical School, Tochigi (Japan); Ikeda, Uichi [Division of Cardiovascular Sciences, Department of Organ Regeneration, Shinshu University Graduate School of Medicine, Matsumoto (Japan)

2006-10-20T23:59:59.000Z

368

Effects of insulin on messenger RNA activities in rat liver  

SciTech Connect (OSTI)

Liver poly(A) RNA, isolated from adrenalectomized rats after insulin treatment, was translated in a nuclease-treated lysate of rabbit reticulocytes and quantitated for both total activity and the capacity to synthesize the insulin-inducible enzyme tyrosine amino-transferase. Analysis of the translated products from poly(A) RNA isolated 1 h after insulin treatment showed a 2.7-fold increase in activity of tyrosine aminotransferase mRNA. During the same interval, the capacity of poly(A) RNA to direct the synthesis of total protein in lysates also changed, showing a 30 to 40% increase in translational activity/unit of RNA. Increased translatability was apparent in all fractions of poly(A) RNA separated by centrifugation on sucrose gradients. Insulin thus appears to mediated a generalized changed in mRNAs leading to increased capacity for translation; induction of tyrosine aminotransferase may reflect unusual sensitivity to this effect of the hormone.

Hill, R.E. (Univ. of Tennessee, Oak Ridge); Lee, K.L.; Kenney, F.T.

1981-02-25T23:59:59.000Z

369

RApid Temporal Survey - RATS I: Overview and first results  

E-Print Network [OSTI]

We present the aim and first results of the RApid Temporal Survey (RATS) made using the Wide Field Camera on the Isaac Newton Telescope. Our initial survey covers 3 square degrees, reaches a depth of V~22.5 and is sensitive to variations on timescales as short as 2 minutes: this is a new parameter space. Each field was observed for over 2 hours in white light, with 12 fields being observed in total. Our initial analysis finds 46 targets which show significant variations. Around half of these systems show quasi-sinusoidal variations: we believe they are contact or short period binaries. We find 4 systems which show variations on a timescale less than 1 hour. The shortest period system has a period of 374 sec. We find two systems which show a total eclipse. Further photometric and spectroscopic observations are required to fully identify the nature of these systems. We outline our future plans and objectives.

Gavin Ramsay; Pasi Hakala

2005-03-07T23:59:59.000Z

370

Deterministic dynamics of neural activity during absence seizures in rats  

Science Journals Connector (OSTI)

The study of brain electrical activities in terms of deterministic nonlinear dynamics has recently received much attention. Forbidden ordinal patterns (FOP) is a recently proposed method to investigate the determinism of a dynamical system through the analysis of intrinsic ordinal properties of a nonstationary time series. The advantages of this method in comparison to others include simplicity and low complexity in computation without further model assumptions. In this paper, the FOP of the EEG series of genetic absence epilepsy rats from Strasbourg was examined to demonstrate evidence of deterministic dynamics during epileptic states. Experiments showed that the number of FOP of the EEG series grew significantly from an interictal to an ictal state via a preictal state. These findings indicated that the deterministic dynamics of neural networks increased significantly in the transition from the interictal to the ictal states and also suggested that the FOP measures of the EEG series could be considered as a predictor of absence seizures.

Gaoxiang Ouyang; Xiaoli Li; Chuangyin Dang; Douglas A. Richards

2009-04-29T23:59:59.000Z

371

Toxicity of depleted uranium on isolated rat kidney mitochondria  

Science Journals Connector (OSTI)

Background Kidney is known as the most sensitive target organ for depleted uranium (DU) toxicity in comparison to other organs. Although the oxidative stress and mitochondrial damage induced by DU has been well investigated, the precise mechanism of DU-induced nephrotoxicity has not been thoroughly recognized yet. Methods Kidney mitochondria were obtained using differential centrifugation from Wistar rats and mitochondrial toxicity endpoints were then determined in both in vivo and in vitro uranyl acetate (UA) exposure cases. Results Single injection of UA (0, 0.5, 1 and 2mg/kg, i.p.) caused a significant increase in blood urea nitrogen and creatinine levels. Isolated mitochondria from the UA-treated rat kidney showed a marked elevation in oxidative stress accompanied by mitochondrial membrane potential (MMP) collapse as compared to control group. Incubation of isolated kidney mitochondria with UA (50, 100 and 200?M) manifested that UA can disrupt the electron transfer chain at complex II and III that leads to induction of reactive oxygen species (ROS) formation, lipid peroxidation, and glutathione oxidation. Disturbances in oxidative phosphorylation were also demonstrated through decreased ATP concentration and ATP/ADP ratio in UA-treated mitochondria. In addition, UA induced a significant damage in mitochondrial outer membrane. Moreover, MMP collapse, mitochondrial swelling and cytochrome c release were observed following the UA treatment in isolated mitochondria. General significance Both our in vivo and in vitro results showed that UA-induced nephrotoxicity is linked to the impairment of electron transfer chain especially at complex II and III which leads to subsequent oxidative stress.

Fatemeh Shaki; Mir-Jamal Hosseini; Mahmoud Ghazi-Khansari; Jalal Pourahmad

2012-01-01T23:59:59.000Z

372

Dose-Response Effect of Charged Carbon Beam on Normal Rat Retina Assessed by Electroretinography  

SciTech Connect (OSTI)

Purpose: To compare the effects of carbon beam irradiation with those of proton beam irradiation on the physiology of the retina of rats. Methods and Materials: Eight-week-old Wister rats were used. The right eyes were irradiated with carbon beam (1, 2, 4, 8, and 16 Gy) or proton beam (4, 8, 16, and 24 Gy) with the rats under general anesthesia. Electroretinograms were recorded 1, 3, 6, and 12 months after the irradiation, and the amplitudes of the a and b waves were compared with those of control rats. Results: The amplitude of b waves was reduced more than that of a waves at lower irradiation doses with both types of irradiation. With carbon ion irradiation, the amplitudes of the b wave were significantly reduced after radiation doses of 8 and 16 Gy at 6 months and by radiation doses of 4, 8, and 16 Gy at 12 months. With proton beam irradiation, the b-wave amplitudes were significantly reduced after 16 and 24 Gy at 6 months and with doses of 8 Gy or greater at 12 months. For the maximum b-wave amplitude, a significant difference was observed in rats irradiated with carbon beams of 4 Gy or more and with proton beams of 8 Gy or more at 12 months after irradiation. Conclusions: These results indicate that carbon beam irradiation is about two times more damaging than proton beam irradiation on the rat retina at the same dose.

Mizota, Atsushi, E-mail: mizota-a@med.teikyo-u.ac.j [Department of Ophthalmology, Teikyo University School of Medicine, Tokyo (Japan); Department of Ophthalmology, Juntendo University Urayasu Hospital, Urayasu (Japan); Tanaka, Minoru [Department of Ophthalmology, Juntendo University Urayasu Hospital, Urayasu (Japan); Kubota, Mariko; Negishi, Hisanari [Department of Ophthalmology, National Hospital Organization Chiba Medical Center, Chiba (Japan); Watanabe, Emiko [Department of Ophthalmology, Teikyo University School of Medicine, Tokyo (Japan); Tsuji, Hiroshi; Miyahara, Nobuyuki; Furusawa, Yoshiya [National Institute of Radiological Sciences, Chiba (Japan)

2010-12-01T23:59:59.000Z

373

Effect of inhalation exposure to 2-bromopropane on the nervous system in rats  

Science Journals Connector (OSTI)

Exposure to 2-bromopropane (2-BP) is suspected to have adverse effects on the nervous system. The aim of this study was to investigate whether the exposure of rats to 2-BP had neurotoxic effects using histological and electrophysiological studies. Wistar strain male rats were exposed daily to either 100 or 1000 ppm 2-BP or to fresh air for 8 h a day for 12 weeks. Body weight was measured before exposure and every 2 weeks. Motor nerve conduction velocity (MCV) and distal latency (DL) were measured before exposure and every 4 weeks during exposure. Histological examination of the nervous system was also performed. Exposure of rats (n=9) to 1000 ppm resulted in suppression of body weight gain and a significant decrease in brain weight compared to the control (n=9). Electrophysiological measurements showed a significant decrease in MCV in 1000 ppm exposed rats at 8 weeks and significant prolongation of DL at 8 and 12 weeks. Abnormalities of the myelin sheath were detected in the common peroneal nerves. In 100-ppm exposed rats (n=9), no significant changes were noted in body weight and the peripheral nerve. In conclusions, long-term exposure to 1000 ppm of 2-BP may result in peripheral neuropathy in rats.

Xiaozhong Yu; Gaku Ichihara; Junzoh Kitoh; Zhenlin Xie; Eiji Shibata; Michihiro Kamijima; Nobuyuki Asaeda; Naomi Hisanaga; Yasuhiro Takeuchi

1999-01-01T23:59:59.000Z

374

Respiratory patterns reflect different levels of aggressiveness and emotionality in Wild-type Groningen rats  

Science Journals Connector (OSTI)

Abstract Respiratory patterns represent a promising physiological index for assessing emotional states in preclinical studies. Since disturbed emotional regulation may lead to forms of excessive aggressiveness, in this study we investigated the hypothesis that rats that differ largely in their level of aggressive behavior display matching alterations in respiration. Respiration was recorded in male high-aggressive (HA, n=8) and non-aggressive (NA, n=8) Wild-type Groningen rats using whole-body plethysmography. Subsequently, anxiety-related behaviors were evaluated in the elevated plus maze and social avoidanceapproach tests. During respiratory testing, HA rats showed elevated basal respiratory rate, reduced sniffing, exaggerated tachypnoeic response to an acoustic stimulus and a larger incidence of sighs. In addition, HA rats spent less time in the open arms of the plus maze and displayed higher levels of social avoidance behavior compared to NA rats. These findings indicate that HA rats are characterized by alterations in respiratory functioning and behavior that are overall indicative of an anxiety-like phenotype.

Luca Carnevali; Eugene Nalivaiko; Andrea Sgoifo

2014-01-01T23:59:59.000Z

375

Automated whole-genome multiple alignment of rat, mouse, and human  

SciTech Connect (OSTI)

We have built a whole genome multiple alignment of the three currently available mammalian genomes using a fully automated pipeline which combines the local/global approach of the Berkeley Genome Pipeline and the LAGAN program. The strategy is based on progressive alignment, and consists of two main steps: (1) alignment of the mouse and rat genomes; and (2) alignment of human to either the mouse-rat alignments from step 1, or the remaining unaligned mouse and rat sequences. The resulting alignments demonstrate high sensitivity, with 87% of all human gene-coding areas aligned in both mouse and rat. The specificity is also high: <7% of the rat contigs are aligned to multiple places in human and 97% of all alignments with human sequence > 100kb agree with a three-way synteny map built independently using predicted exons in the three genomes. At the nucleotide level <1% of the rat nucleotides are mapped to multiple places in the human sequence in the alignment; and 96.5% of human nucleotides within all alignments agree with the synteny map. The alignments are publicly available online, with visualization through the novel Multi-VISTA browser that we also present.

Brudno, Michael; Poliakov, Alexander; Salamov, Asaf; Cooper, Gregory M.; Sidow, Arend; Rubin, Edward M.; Solovyev, Victor; Batzoglou, Serafim; Dubchak, Inna

2004-07-04T23:59:59.000Z

376

Effects of subchronic inhalation exposure to carbon black nanoparticles in the nasal airways of laboratory rats  

Science Journals Connector (OSTI)

The nose can be an efficient filter for inhaled gases, vapours and particles that may be harmful to the lung. Nasal airways may also be targets for injury caused by inhaled toxicants. To investigate the nasal toxicity of carbon black nanoparticles (CB), rats were exposed to 0, 1, 7 or 50 mg/m³ of high surface area CB (HSCB; primary particle size 17 nm; particle surface area 300 m²/g) for 6 h/day, 5 days/week for 13 week. Additional rats were exposed to 50 mg/m³ of low surface area CB (LSCB; primary particle size 70 nm; particle surface area 37 m²/g). Rats were sacrificed 1 day, 13 week, or 11 months postexposure (PE). Rats exposed to mid- or high-dose HSCB had nasal inflammatory and epithelial lesions at one day PE. HSCB-induced nasal inflammation resolved by 13 week PE, but some nasal epithelial lesions were still present in rats at 11 months after high-dose HSCB exposure. Low-dose HSCB or high-dose LSCB induced only minimal epithelial lesions that were resolved by 13 week PE. Results indicate that incidence, severity, and persistence of CB-induced nasal toxicity in rats is dependent on exposure concentration, particle surface area, and time PE. Effects of inhaled CB on human nasal airways are yet to be determined.

Priya Santhanam; James G. Wagner; Alison Elder; Robert Gelein; Janet M. Carter; Kevin E. Driscoll; Gunter Oberdorster; Jack R. Harkema

2008-01-01T23:59:59.000Z

377

Eur J Nucl Med Mol Imaging. Author manuscript Assessment of insulin resistance in fructose-fed rats with 125  

E-Print Network [OSTI]

in fructose-fed rats with 125 I-6-deoxy-6-iodo-D-glucose, a new tracer of glucose transport Perret Pascale 1 was to assess variations in glucose transport in rats with I-6-Deoxy-6-Iodo-D-glucose (6DIG), a new tracer protocol, in awake control and insulin-resistant fructose-fed rats. The tracer was injected at steady state

Paris-Sud XI, Université de

378

Phase cphalique de scrtion d'insuline et varit des aliments au cours du repas chez le rat  

E-Print Network [OSTI]

Phase céphalique de sécrétion d'insuline et variété des aliments au cours du repas chez le rat and varied meals in rat. Immunologically reactive insulin levels were determined in freely-moving normal rats. It was shown that in a varied meal (tests 11 and 111), the ingestion of each new food was immediately followed

Boyer, Edmond

379

Differences in pulmonary responses of rats, other animals, and humans to chronic inhalation of silica and other particles  

SciTech Connect (OSTI)

The pulmonary carcinogenicity of quartz in rats supports the plausibility of silica-induced lung cancer in humans. However, pulmonary responses of rats to dusts differ from those of other rodents, and may differ from those of humans. Dust-exposed rats have a greater propensity than mice or hamsters for epithelial hyperplasia, metaplasia, and fibrosis. Lung tumors occur in rats, but not mice or hamsters, treated with quartz, or exposed chronically to several other dusts. There are few opportunities for directly comparing the susceptibilities of rats and humans to dust-induced lung tumors. Because of the uncertain human responses to silica and many other particles, the negative human lung cancer response to coal dust may provide the best opportunity to calibrate responses of rats against those of humans. Historical dust lung burdens in coal miners were in the range of those associated with carcinogenicity in rats exposed to several dusts, but the carcinogenicity of coal dust in rats is unknown. The usefulness of tumor data from rats for predicting human lung cancer risk from inhaled silica and other dusts remains uncertain.

Mauderly, J.L.

1993-12-31T23:59:59.000Z

380

The effects of exercise and dietary fat on calcium, magnesium, iron, and zinc on selected tissues in rats  

E-Print Network [OSTI]

and had a 12-hour photoperiod. Cages were lined with woodchip bedding, and stainless steel feeders were used. Design Following a three-day acclimation period, during which rats were fed the control diet, the rats were weighed and randomly assigned... the reliability of exhaustive swimming in the laboratory rat. Male albino rats exhibited exercise oxygen consumption of 2. 7 times the resting level in a no-weight applied condition after swimming for 5 to 30 minutes. At a load of 2% body weight, oxygen...

Nguyen, Thuy Huong

1989-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Influences of TNT-Food Pairings on the Performance of Mine Detection Rats in Early Training Stages.  

E-Print Network [OSTI]

?? Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling (APOPO), a Belgian nongovernmental organization headquartered in Tanzania, trains giant African pouched rats (Cricetomys gambianus) to detect land mines and (more)

Edwards, Timothy L.

2013-01-01T23:59:59.000Z

382

Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats  

SciTech Connect (OSTI)

Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. The presence of BPA in urine of > 90% of Americans aged 6-60 suggests ubiquitous and frequent exposure. The current study used LC/MS/MS to measure serum pharmacokinetics of aglycone (active) and conjugated (inactive) BPA in adult and neonatal Sprague-Dawley rats by oral and injection routes. Deuterated BPA was used to avoid issues of background contamination. Linear pharmacokinetics were observed in adult rats treated orally in the range of 0-200 {mu}g/kg bw. Evidence for enterohepatic recirculation of conjugated, but not aglycone, BPA was observed in adult rats. Significant inverse relationships were observed between postnatal age and measures of internal exposures to aglycone BPA and its elimination. In neonatal rats treated orally, internal exposures to aglycone BPA were substantially lower than from subcutaneous injection. The results reinforce the critical role for first-pass Phase II metabolism of BPA in gut and liver after oral exposure that attenuates internal exposure to the aglycone form in rats of all ages. The internal exposures to aglycone BPA observed in adult and neonatal rats following a single oral dose of 100 {mu}g/kg bw are inconsistent with effects mediated by classical estrogen receptors based on binding affinities. However, an impact on alternative estrogen signaling pathways that have higher receptor affinity cannot be excluded in neonatal rats. These findings emphasize the importance of matching aglycone BPA internal dosimetry with receptor affinities in experimental animal studies reporting toxicity.

Doerge, Daniel R., E-mail: daniel.doerge@fda.hhs.go [Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079 (United States); Twaddle, Nathan C.; Vanlandingham, Michelle [Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079 (United States); Fisher, Jeffrey W. [Department of Environmental Health Sciences, College of Public Health, University of Georgia, Athens, GA 30602 (United States)

2010-09-01T23:59:59.000Z

383

Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats  

Science Journals Connector (OSTI)

?Using the olfactory bulbectomy model of depression, we examined the antidepressant-like activity of 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats. Bulbectomized rats required a significantly greater numb...

J. M. Wieronska; B. Szewczyk; P. Branski; A. Palucha; A. Pilc

2002-09-01T23:59:59.000Z

384

Effects of Timing and Quantity of Chronic Dietary Ethanol Consumption on Azoxymethane-induced Colonic Carcinogenesis and Azoxymethane Metabolism in Fischer 344 Rats  

Science Journals Connector (OSTI)

...Dose-Response Relationship, Drug Energy Intake Ethanol toxicity Male Rats Rats...in previous studies to energy wastage associated with ethanol metabolism (29). The...feeding, possibly due to energy wastage by ethanol metabolism (29). Bottom...

Stanley R. Hamilton; Ock Soon Sohn; and Emerich S. Fiala

1987-08-15T23:59:59.000Z

385

Delay Discounting in Lewis and Fischer 344 Rats: Implications for the Use of an Adjusting-amount Procedure to Detect Between-strain Differences  

E-Print Network [OSTI]

Strain-related behavioral differences may facilitate investigation of the genetic and neurochemical determinants of delay discounting. Previous researchers report that Lewis rats make more impulsive choices than Fischer 344 rats, although the size...

Stein, Jeff S.

2010-07-21T23:59:59.000Z

386

Effects on food intake following stimulation of alpha1- and alpha2-adrenoceptors within the hypothalamic paraventricular nucleus of dietary-obese and dietary-resistant rats.  

E-Print Network [OSTI]

??Rats fed diets high in fat and sucrose exhibit varying degrees of obesity. Studies have sought to define differences between dietary-obese (DIO) rats and dietary-resistant (more)

McMahon, Lance Richard

2012-01-01T23:59:59.000Z

387

Effect of acute and chronic ethanol administration on the content of coenzymes linked to energy transfer in the liver of rats fed standard or low-protein diet  

Science Journals Connector (OSTI)

1) In rats fed a standard diet or a protein restricted diet the effect of acute and chronic ethanol administrati...

Hiroshi Kono M.D.; J. Ch. Bode M.D.; G. A. Martini M.D.

1979-06-01T23:59:59.000Z

388

Effects on food intake following stimulation of alpha1- and alpha2-adrenoceptors within the hypothalamic paraventricular nucleus of dietary-obese and dietary-resistant rats  

E-Print Network [OSTI]

Rats fed diets high in fat and sucrose exhibit varying degrees of obesity. Studies have sought to define differences between dietary-obese (DIO) rats and dietary-resistant (DR) rats which may contribute to the cause or development of obesity...

McMahon, Lance Richard

2012-06-07T23:59:59.000Z

389

Use of Microdosing and Accelerator Mass Spectrometry To Evaluate the Pharmacokinetic Linearity of a Novel Tricyclic GyrB/ParE Inhibitor in Rats  

Science Journals Connector (OSTI)

...Novel Tricyclic GyrB/ParE Inhibitor in Rats Michael A. Malfatti a Victoria Lao a Courtney...preclinical drug candidate (GP-4) in rats as a step toward human microdosing studies...pharmacological dose was assessed in Sprague-Dawley rats. Plasma PKs over the 3 pharmacological...

Michael A. Malfatti; Victoria Lao; Courtney L. Ramos; Voon S. Ong; Kenneth W. Turteltaub

2014-08-18T23:59:59.000Z

390

Enhanced Survival and Cure of F98 GliomaBearing Rats following Intracerebral Delivery of Carboplatin in Combination with Photon Irradiation  

Science Journals Connector (OSTI)

...Survival and Cure of F98 Glioma-Bearing Rats following Intracerebral Delivery of Carboplatin...for the treatment of F98 glioma-bearing rats. Experimental Design: Carboplatin (20...i.c. by CED to F98 glioma-bearing rats, 13 days after stereotactic implantation...

Julia Rousseau; Caroline Boudou; Rolf F. Barth; Jacques Balosso; Franois Estve; Hlne Elleaume

2007-09-01T23:59:59.000Z

391

Gestational and early postnatal dietary NaCl levels affect NaCl intake, but not stimulated water intake, by adult rats  

E-Print Network [OSTI]

intake, by adult rats Kathleen S. Curtis, Eric G. Krause, Donna L. Wong, and Robert J. Contreras affect NaCl intake, but not stimulated water intake, by adult rats. Am J Physiol Regul Integr Comp examined body fluid regulation by weanling (21­25 days) and adult ( 60 days) male rats that were offspring

Hull, Elaine

392

Endogenous N-nitroso compounds, and their precursors, present in bacon, do not initiate or promote aberrant crypt foci in the colon of rats  

E-Print Network [OSTI]

aberrant crypt foci in the colon of rats Parnaud G. 1 , Pignatelli B. 2 , Peiffer G. 1 , Taché S. 1 increase fecal NOC levels and colon carcinogenesis was tested in 175 F344 rats. Initiation was assessed by the number of aberrant crypt foci (ACF) in the colon of rats, 45 days after the start of a high-fat bacon

Paris-Sud XI, Université de

393

Antisense to NPY-Y1 Demonstrates that Y1 Receptors in the Hypothalamus Underlie NPY Hypothermia and Feeding in Rats  

Science Journals Connector (OSTI)

...Underlie NPY Hypothermia and Feeding in Rats F. J. Lopez-Valpuesta J. W. Nyce...physiological responses. In the unrestrained rat, the ventromedial hypothalamus (VMH...implanted bilaterally in the brain of 19 rats, 0.4 or 0.8 g per 0.8 l of the phosphorothioate...

1996-01-01T23:59:59.000Z

394

Efficacy of Fosfomycin Compared to Vancomycin in Treatment of Implant-Associated Chronic Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats  

Science Journals Connector (OSTI)

...Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats Wolfgang Poeppl a Tilman Lingscheid a...MRSA) osteomyelitis in an experimental rat model. The proximal tibiae were inoculated...controlled animal study using an experimental rat model of chronic implant-associated MRSA...

Wolfgang Poeppl; Tilman Lingscheid; Dominik Bernitzky; Uwe Y. Schwarze; Oliver Donath; Thomas Perkmann; Nicolas Kozakowski; Roberto Plasenzotti; Gottfried Reznicek; Heinz Burgmann

2014-06-16T23:59:59.000Z

395

Dietary apigenin and naringenin protect against colon carcinogenesis by lowering high multiplicity aberrant crypt foci and enhancing apoptosis in azoxymethane-treated rats  

E-Print Network [OSTI]

investigated the potentially protective effects of four citrus flavonoids and one limonoid mixture against the promotion stage of chemically-induced colon cancer in rats. Male SD rats (n =60; 10 rats/group) were assigned to receive diets containing 0...

Leonardi, Tety

2006-08-16T23:59:59.000Z

396

Facilitation of efficient search of an unbaited radial-arm maze in rats by D1, but not D2, dopamine receptors  

E-Print Network [OSTI]

). This finding is in accord with other evidence that rats without food reward perform similarly to rewardedFacilitation of efficient search of an unbaited radial-arm maze in rats by D1, but not D2, dopamine conditioned preparatory behaviors in rats. We provide added evidence that increased D1 receptor activation

Timberlake, William D.

397

BurrowView Seeing the world through the eyes of rats Jo Agila Bitsch Link, Gregor Fabritius, Muhammad Hamad Alizai, Klaus Wehrle  

E-Print Network [OSTI]

BurrowView ­ Seeing the world through the eyes of rats J´o ´Agila Bitsch Link, Gregor FabritiusView, an application that tracks the movement of rats in their natural habitat and reconstructs the under- ground to the information quality. Our system is able to reconstruct paths up to a resolution of 20 cm, the length of a rat

398

Fluid mechanical consequences of pendular activity, segmentation, and pyloric1 outflow in the proximal duodenum of the rat and the guinea pig2  

E-Print Network [OSTI]

in the proximal duodenum of the rat and the guinea pig2 3 Clément de Loubens1* , Roger G. Lentle2 , Richard J Alimentaires, INRA, AgroParisTech, CBAI 78850 Thiverval Grignon,6 France7 2 Institute of Food, Nutrition of the rat and guinea pig.22 During pendular activity in the rat duodenum, the flow was pulsatile

Boyer, Edmond

399

ATTRACTIVENESS OF CARBON DISULFIDE TO WILD NORWAY RATS J. RUSSELL MASON, U.S. Deparunent of Agriculture, Animal and Plant Health Inspection Service, Denver Wildlife  

E-Print Network [OSTI]

Heiber 1976). When faced with a choice among several novel foods, naive (observer) rats choose novelATTRACTIVENESS OF CARBON DISULFIDE TO WILD NORWAY RATS J. RUSSELL MASON, U.S. Deparunent) increases the attractiveness of feeding stations to rats and mice. Bait consumption is also increased

Galef Jr., Bennett G.

400

RApid Temporal Survey - RATS II: Followup observations of 4 newly discovered short period variables  

E-Print Network [OSTI]

The RApid Temporal Survey (RATS) is a survey to detect objects whose optical intensity varies on timescales of less than ~70 min. In our pilot dataset taken with the INT and the Wide Field Camera in Nov 2003 we discovered nearly 50 new variable objects. Many of these varied on timescales much longer than 1 hr. However, only 4 objects showed a modulation on a timescale of 1 hour or less. This paper presents followup optical photometry and spectroscopy of these 4 objects. We find that RAT J0455+1305 is a pulsating (on a period of 374 sec) subdwarf B (sdB) star of the EC 14026 type. We have modelled its spectrum and determine Teff = 29,200+/- 1900K and log g = 5.2+/-0.3 which locates it on the cool edge of the EC 14026 instability strip. It has a modulation amplitude which is one of the highest of any known EC 14026 star. Based on their spectra, photometric variability and their infra-red colours, we find that RAT J0449+1756, RAT J0455+1254 and RAT J0807+1510 are likely to be SX Phe stars - dwarf Delta Sct stars. Our results show that our observing strategy is a good method for finding rare pulsating stars.

Gavin Ramsay; Ralf Napiwotzki; Pasi Hakala; Harry Lehto

2006-06-26T23:59:59.000Z

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Palatable food avoidance and acceptance learning with different stressors in female rats  

Science Journals Connector (OSTI)

Stress activates the hypothalamuspituitaryadrenal (HPA) axis leading to the release of glucocorticoids (GC). Increased activity of the HPA axis and GC exposure has been suggested to facilitate the development of obesity and metabolic syndrome. Nonetheless, different stressors can produce distinct effects on food intake and may support different directions of food learning e.g. avoidance or acceptance. This study examined whether interoceptive (LiCl and exendin-4) and restraint stress (RS) support similar or distinct food learning. Female rats were exposed to different stressors after their consumption of a palatable food (butter icing). After four palatable foodstress pairings, distinct intakes of the butter icing were observed in rats treated with different stressors. Rats that received butter icing followed by intraperitoneal injections of LiCl (42.3mg/kg) and exendin-4 (10?g/kg) completely avoided the palatable food with subsequent presentations. In contrast, rats experiencing RS paired with the palatable food increased their consumption of butter icing across trials and did so to a greater degree than rats receiving saline injections. These data indicate that interoceptive and psychosocial stressors support conditioned food avoidance and acceptance, respectively. Examination of c-Fos immunoreactivity revealed distinct neural activation by interoceptive and psychosocial stressors that could provide the neural basis underlying opposite direction of food acceptance learning.

N.-C. Liang; M.E. Smith; T.H. Moran

2013-01-01T23:59:59.000Z

402

Effects of inhaled 1-bromopropane vapor on rat metabolism  

Science Journals Connector (OSTI)

Wistar male rats were exposed to 1-bromopromane (1-BP) vapor for 6 h a day, 5 days a week, for 3 and 4 weeks (1500 ppm) and 1 day, and 4 and 12 weeks (700 ppm). After the exposures, 1-BP and its metabolites were measured temporally. In the samples obtained from the 700 ppm exposures, hematological and biochemical examinations in blood and measurements of hepatic cytochromes P450 were carried out. 1-BP in blood decreased rapidly to the detection limit within 0.7 h. On the other hand, bromine ion persisted longer in both blood and urine; the biological half-life of bromine ion was 4.715.0 days in blood and 5.07.5 days in urine. Glycidol was detected in the urine samples. Based on the experimental results, the metabolic pathway of 1-BP was discussed. Hepatic cytochromes P450, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in blood decreased significantly with 1-BP exposure, but other enzyme activities did not differ significantly.

Toru Ishidao; Naoki Kunugita; Yukiko Fueta; Keiichi Arashidani; Hajime Hori

2002-01-01T23:59:59.000Z

403

The Circulation of Malignant Lymphoid Cells in Thoracic Duct Lymph of Rats with Lymphosarcoma and Lymphatic Leukemia  

Science Journals Connector (OSTI)

...fistulae were estab lished in four groups of rats, including untreated...Prairie City, Quebec, Canada. Four groups of rats were investigated...is required to clarify this point. Although the experimental...Goldenberg |W tfk1 2 3 1 HO00 00 lift (IOOP M M* a I AA XX 14 17...

B. K. Sinha and Gerald J. Goldenberg

1970-09-01T23:59:59.000Z

404

Metabolic Basis for the Protective Effect of the Antioxidant Ethoxyquin on Aflatoxin B1 Hepatocarcinogenesis in the Rat  

Science Journals Connector (OSTI)

...George Washington University Medical Center. To whom requests for...George Washington University Medical Center, 2300 Eye St., NW...rats/cage) under controlled lighting and tem perature. Control animals were fed a diet of powdered Medical Research Council 41B rat and...

H. George Mandel; Margaret M. Manson; David J. Judah; Janet L. Simpson; Jonathan A. Green; Lesley M. Forrester; C. Roland Wolf; and Gordon E. Neal

1987-10-01T23:59:59.000Z

405

Deregulation of Hepatic Insulin Sensitivity Induced by Central Lipid Infusion in Rats Is Mediated by Nitric Oxide  

E-Print Network [OSTI]

Deregulation of Hepatic Insulin Sensitivity Induced by Central Lipid Infusion in Rats Is Mediated effect of central lipid overload. Thus we infused rats for 24 hours into carotid artery towards brain). Principal Findings: Lipids infusion led to hepatic insulin-resistance partly related to a decreased

Routh, Vanessa H.

406

Neutral sphingomyelinase inhibition participates to the benefits of N-acetylcysteine treatment in post-myocardial infarction failing heart rats  

E-Print Network [OSTI]

treatment in post- myocardial infarction failing heart rats Christophe ADAMY1,2,9 , Paul MULDER3,4,9 , Lara-MI failing heart rat Key words: chronic heart failure; glutathione; N-acetylcysteine; neutral, we showed that the left ventricle (LV) of human failing heart was depleted in total glutathione by 54

Paris-Sud XI, Université de

407

Dietary Calcium and Vitamin D Modulate 1,2-Dimethylhydrazine-induced Colonic Carcinogenesis in the Rat  

Science Journals Connector (OSTI)

...c. injections of either vehicle or DMH (20 mg/kg body weight...after 15 weeks of exposure to vehicle or DMH, before development...observations, international ecological data (25) as well as two...DMH- treated rats and 6-8 vehicle-treated rats/dietary group...

Michael D. Sitrin; Allan G. Halline; Cyril Abrahams; and Thomas A. Brasitus

1991-10-15T23:59:59.000Z

408

This information sheet is for the care and use of laboratory rodents (including rats, mice, hamsters, guinea pigs & gerbils).  

E-Print Network [OSTI]

This information sheet is for the care and use of laboratory rodents (including rats, mice, transmission is thought to occur by the fecal- oral route through contamination of food or water, or by direct. The source of infection can be from any of the following: rats, mice, voles, hedgehogs, gerbils, squirrels

Wood, Marcelo A.

409

The effects of forced nest-site feeding on the food preferences of wild rat pups at weaning*  

E-Print Network [OSTI]

The effects of forced nest-site feeding on the food preferences of wild rat pups at weaning preferences of wild rat pups during weaning. The results indicated that although food preferences during reported below examined the role of the ingestion of food samples at the nest site on the feeding

Galef Jr., Bennett G.

410

Belg. J. Zool., 135 (supplement) : 69-75 December 2005 Noki or dassie-rat (Petromus typicus) feeding ecology  

E-Print Network [OSTI]

Belg. J. Zool., 135 (supplement) : 69-75 December 2005 Noki or dassie-rat (Petromus typicus author : Galen B. Rathbun, e-mail : grathbun@calacademy.org ABSTRACT. The noki or dassie-rat (Petromus and stems. Relatively few plants and plant parts were avoided. There was no indication that food was cached

411

Obese and lean Zucker rats demonstrate differential sensitivity to rates of food reinforcement in a choice procedure  

Science Journals Connector (OSTI)

The obese Zucker rat carries two recessive fa alleles that result in the expression of an obese phenotype. Obese Zuckers have higher food intake than lean controls in free-feed studies in which rats have ready access to a large amount of one type of food. The present study examined differences in obese and lean Zucker rats using concurrent schedules of reinforcement, which more ecologically models food selection using two food choices that have limited, but generally predictable availability. Lever-pressing of ten lean (Fa/Fa or Fa/fa) and ten obese (fa/fa) Zucker rats was placed under three concurrent variable interval variable interval (conc VI VI) schedules of sucrose and carrot reinforcement, in which the programmed reinforcer ratios for 45-mg food pellets were 5:1, 1:1, and 1:5. Allocation of responses to the two food alternatives was characterized using the generalized matching equation, which allows sensitivity to reinforcer rates (a) and bias toward one alternative (log k) to be quantified. All rats showed a bias toward sucrose, though there were no differences between lean and obese Zucker rats. In addition, obese Zucker rats exhibited higher sensitivity to reinforcement rates than lean rats. This efficient pattern of responding was related to overall higher deliveries of food pellets. Effective matching for food, then, may be another behavioral pattern that contributes to an obese phenotype.

Jessica L. Buckley; Erin B. Rasmussen

2012-01-01T23:59:59.000Z

412

LCAPCI-MSMS Method for the Tissue Distribution of Viaminate After Oral Administrations to Rats  

Science Journals Connector (OSTI)

......After Oral Administrations to Rats Ling Cao 1 2 Feng Zheng 1 Pengcheng Ma 3 * Wenying Liu 1 * Di Sun 1 Xuan Chen 1 Yanwei Lai 1 Meng...Oral Administrations to Rats Ling Cao1,2, Feng Zheng1, Pengcheng Ma3,*, Wenying Liu1,*, Di Sun1, Xuan Chen1, Yanwei......

Ling Cao; Feng Zheng; Pengcheng Ma; Wenying Liu; Di Sun; Xuan Chen; Yanwei Lai; Meng Gou

2008-09-01T23:59:59.000Z

413

Acetyldinaline: A New Oral Cytostatic Drug with Impressive Differential Activity against Leukemic Cells and Normal Stem CellsPreclinical Studies in a Relevant Rat Model for Human Acute Myelocytic Leukemia  

Science Journals Connector (OSTI)

...v. cellular transfer within the Brown Norway rat strain. Cytologically and cytochemically...and treated BNML rats into normal Brown Norway rats results in death of rats from leukemia...effect on mitochondria and thus on the energy metabolism of the cells but the precise...

H. M. El-Beltagi; A. C. M. Martens; P. Lelieveld; E. A. Haroun; and A. Hagenbeek

1993-07-01T23:59:59.000Z

414

Application of synchrotron radiation computed microtomography for quantification of bone microstructure in human and rat bones  

SciTech Connect (OSTI)

This work aims to evaluate histomorphometric quantification by synchrotron radiation computed microto-mography in bones of human and rat specimens. Bones specimens are classified as normal and pathological (for human samples) and irradiated and non-irradiated samples (for rat ones). Human bones are specimens which were affected by some injury, or not. Rat bones are specimens which were irradiated, simulating radiotherapy procedures, or not. Images were obtained on SYRMEP beamline at the Elettra Synchrotron Laboratory in Trieste, Italy. The system generated 14 {mu}m tomographic images. The quantification of bone structures were performed directly by the 3D rendered images using a home-made software. Resolution yielded was excellent what facilitate quantification of bone microstructures.

Parreiras Nogueira, Liebert; Barroso, Regina Cely; Pereira de Almeida, Andre; Braz, Delson; Almeida, Carlos Eduardo de; Borba de Andrade, Cherley; Tromba, Giuliana [Nuclear Instrumentation Laboratory / COPPE / UFRJ, P.O. Box 68509, 21945-970, Rio de Janeiro (Brazil); Physics Institute / State University of Rio de Janeiro, 20550-900, Rio de Janeiro (Brazil); Nuclear Instrumentation Laboratory / COPPE / UFRJ, P.O. Box 68509, 21945-970, Rio de Janeiro (Brazil); Laboratory of Radiological Sciences / State University of Rio de Janeiro, Rio de Janeiro (Brazil); Sincrotrone Trieste SCpA, Strada Statale S.S. 14 km 163.5, 34012 Basovizza, Trieste (Italy)

2012-05-17T23:59:59.000Z

415

Species-specific toxicity of troglitazone on rats and human by gel entrapped hepatocytes  

SciTech Connect (OSTI)

Troglitazone, despite passing preclinical trials on animals, was shortly withdrawn from market due to its severe hepatotoxicity in clinic. As rat hepatocyte monolayer consistently showed sensitive troglitazone toxicity as human hepatocyte monolayer in contrast to the species-specific toxicity in vivo, this paper utilized both hepatocytes in three-dimensional culture of gel entrapment to reflect the species difference on hepatotoxicity. Rat hepatocytes in gel entrapment did not show obvious cellular damage even under a long-term exposure for 21 days while gel entrapped human hepatocytes significantly displayed oxidative stress, steatosis, mitochondrial damage and cell death at a short exposure for 4 days. As a result, the detected species-specific toxicity of troglitazone between gel entrapped rat and human hepatocytes consisted well with the situation in vivo but was in a sharp contrast to the performance of two hepatocytes by monolayer culture. Such contradictory toxicity of rat hepatocytes between monolayer and gel entrapment culture could be explained by the fact that troglitazone was cleared more rapidly in gel entrapment than in monolayer culture. Similarly, the differential clearance of troglitazone in rat and human might also explain its species-specific toxicity. Therefore, gel entrapment of hepatocytes might serve as a platform for evaluation of drug toxicity at early stage of drug development by reducing costs, increasing the likelihood of clinical success and limiting human exposure to unsafe drugs. -- Highlights: ? Species-specific toxicity of troglitazone reflected by rat/human hepatocytes ? 3D hepatocytes in 21 days long-term culture used for drug hepatotoxicity ? Oversensitive toxicity in hepatocyte monolayer by slow troglitazone clearance.

Shen, Chong [College of Materials Science and Chemical Engineering, Zhejiang University, Zhejiang 310027 (China)] [College of Materials Science and Chemical Engineering, Zhejiang University, Zhejiang 310027 (China); Meng, Qin, E-mail: mengq@zju.edu.cn [College of Materials Science and Chemical Engineering, Zhejiang University, Zhejiang 310027 (China)] [College of Materials Science and Chemical Engineering, Zhejiang University, Zhejiang 310027 (China); Zhang, Guoliang [Institute of Biological and Environmental Engineering, Zhejiang University of Technology, Zhejiang 310012 (China)] [Institute of Biological and Environmental Engineering, Zhejiang University of Technology, Zhejiang 310012 (China)

2012-01-01T23:59:59.000Z

416

The inability of rats to synthesize linoleic acid from cis-2-octenoic acid  

E-Print Network [OSTI]

THE INABILITY OF RATS TO SYNTHESI2E LINOLEIC ACID FROM CIS-2-OCTENOIC ACID A Thesis Robert Eugene Anderson Submitted to the Graduate College of the Texas A g: M University in partia1 fulfillment of the requirerents for the degree of MASTER... OF SCIENCE January 1965 Major Subjeot: Bioohemistry THE INABILITY OF RATS TQ SYNTHESIEE LINOLEIC ACID FROM CIS-2E)CTENOIC ACID A Thesis Robert, Eugene Anderson Approved as to style and content by: Chair n of Committee)~ (Head of Depart~ant, Member...

Anderson, Robert Eugene

2012-06-07T23:59:59.000Z

417

A study of the effect of restricted diets in the male albino rat  

E-Print Network [OSTI]

CLon exxpertment metabolic rate was also osti mated by means ?f serum clearance of radioactive I?dine. This determination was ne during tho twenty fourth week of the superi ment on five animals from each Creatment group. Each rat was infected intraperitoneally...CLon exxpertment metabolic rate was also osti mated by means ?f serum clearance of radioactive I?dine. This determination was ne during tho twenty fourth week of the superi ment on five animals from each Creatment group. Each rat was infected intraperitoneally...

Griffin, Travis Barton

2012-06-07T23:59:59.000Z

418

Effects of stress odors on escape-avoidance learning in rats  

E-Print Network [OSTI]

and Brown(1969) tested four g. cups of rats in exploration of an open field maze. 'The g cups were; anosmic as a r esult of ablation of the lfactory bulb; b 1 in ' d; anosmic and blinded; and contro 1 anima 1 s . Litho 'gh ti c f ir st thr ee groups... and Brown(1969) tested four g. cups of rats in exploration of an open field maze. 'The g cups were; anosmic as a r esult of ablation of the lfactory bulb; b 1 in ' d; anosmic and blinded; and contro 1 anima 1 s . Litho 'gh ti c f ir st thr ee groups...

Sears, Judy Embry

2012-06-07T23:59:59.000Z

419

Toxicity of polychlorinated diphenyl ethers in Hydra attenuata and in rat whole embryo culture  

E-Print Network [OSTI]

TOXICITY OF POLYCHLORINATED DIPHENYL ETHERS IN HYDRA A?TENUATA AND IN RAT WHOLE EMBRYO CULTURE A Thesis by MARION CAROL BECKER Submitted to the Office of Graduate Studies of Texas A8cM University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE May 1991 Major Subject: Toxicology TOXICITY OF POLYCHLORINATED DIPHENYL ETHERS IN HYDRA A1TENUATA AND IN RAT WHOLE EMBRYO CULTURE by MARION CAROL BECKER Approved as to style and content by: Stephen H. S (Ca...

Becker, Marion Carol

2012-06-07T23:59:59.000Z

420

Chronic cellular responses of rat skin to 13 Mev proton irradiation  

E-Print Network [OSTI]

CHRONIC CELLULAR RESPONSES OF RAT SKIN TO 13 MEV PROTON IRRADIATION A Thesis by DONALD KING HINKLE, D. V. M. Submitted to the Graduate College of the Texas AErM University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE August 1966 Major Subject: Laboratory Animal Medicine CHRONIC CELLULAR RESPONSES OF RAT SKIN TO 13 MEV PROTON IRRADIATION A Thesis by DONALD KING HINKLE, D. V. M. Submitted to the Graduate College of the Texas ARM University in partial...

Hinkle, Donald King

2012-06-07T23:59:59.000Z

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Hippocampal phosphoproteomics of F344 rats exposed to 1-bromopropane  

Science Journals Connector (OSTI)

Abstract 1-Bromopropane (1-BP) is neurotoxic in both experimental animals and human. To identify phosphorylated modification on the unrecognized post-translational modifications of proteins and investigate their role in 1-BP-induced neurotoxicity, changes in hippocampal phosphoprotein expression levels were analyzed quantitatively in male F344 rats exposed to 1-BP inhalation at 0, 400, or 1000ppm for 8h/day for 1 or 4weeks. Hippocampal protein extracts were analyzed qualitatively and quantitatively by Pro-Q Diamond gel staining and SYPRO Ruby staining coupled with two-dimensional difference in gel electrophoresis (2D-DIGE), respectively, as well as by matrix-assisted laser-desorption ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) to identify phosphoproteins. Changes in selected proteins were further confirmed by Manganese II (Mn2+)-Phos-tag SDS-polyacrylamide gel electrophoresis (SDS-PAGE). Bax and cytochrome c protein levels were determined by western blotting. Pro-Q Diamond gel staining combined with 2D-DIGE identified 26 phosphoprotein spots (p<0.05), and MALDI-TOF/MS identified 18 up-regulated proteins and 8 down-regulated proteins. These proteins are involved in the biological process of response to stimuli, metabolic processes, and apoptosis signaling. Changes in the expression of phosphorylated 14-3-3 ? were further confirmed by Mn2+-Phos-tag SDS-PAGE. Western blotting showed overexpression of Bax protein in the mitochondria with down-regulation in the cytoplasm, whereas cytochrome c expression was high in the cytoplasm but low in the mitochondria after 1-BP exposure. Our results suggest that the pathogenesis of 1-BP-induced hippocampal damage involves inhibition of antiapoptosis process. Phosphoproteins identified in this study can potentially serve as biomarkers for 1-BP-induced neurotoxicity.

Zhenlie Huang; Sahoko Ichihara; Shinji Oikawa; Jie Chang; Lingyi Zhang; Shijie Hu; Hanlin Huang; Gaku Ichihara

2014-01-01T23:59:59.000Z

422

Metabolism and disposition of 1-bromopropane in rats and mice following inhalation or intravenous administration  

Science Journals Connector (OSTI)

Workplace exposure to 1-bromopropane (1-BrP) can potentially occur during its use in spray adhesives, fats, waxes, and resins. 1-BrP may be used to replace ozone depleting solvents, resulting in an increase in its annual production in the US, which currently exceeds 1 million pounds. The potential for human exposure to 1-BrP and the reports of adverse effects associated with potential occupational exposure to high levels of 1-BrP have increased the need for the development of biomarkers of exposure and an improved understanding of 1-BrP metabolism and disposition. In this study, the factors influencing the disposition and biotransformation of 1-BrP were examined in male F344 rats and B6C3F1 mice following inhalation exposure (800ppm) or intravenous administration (5, 20, and 100mg/kg). [1,2,3-13C]1-BrP and [1-14C]1-BrP were administered to enable characterization of urinary metabolites using NMR spectroscopy, LCMS/MS, and HPLC coupled radiochromatography. Exhaled breath volatile organic chemicals (VOC), exhaled CO2, urine, feces, and tissues were collected for up to 48h post-administration for determination of radioactivity distribution. Rats and mice exhaled a majority of the administered dose as either VOC (4072%) or 14CO2 (1030%). For rats, but not mice, the percentage of the dose exhaled as VOC increased between the mid (?50%) and high (?71%) dose groups; while the percentage of the dose exhaled as 14CO2 decreased (19 to 10%). The molar ratio of exhaled 14CO2 to total released bromide, which decreased as dose increased, demonstrated that the proportion of 1-BrP metabolized via oxidation relative to pathways dependent on glutathione conjugation is inversely proportional to dose in the rat. [14C]1-BrP equivalents were recovered in urine (1317%, rats; 1423% mice), feces (rats and mice administered i.v. 5 to 100mg/kg [14C]1-BrP. Metabolites characterized in urine of rats and mice include N-acetyl-S-propylcysteine, N-acetyl-3-(propylsulfinyl)alanine, N-acetyl-S-(2-hydroxypropyl)cysteine, 1-bromo-2-hydroxypropane-O-glucuronide, N-acetyl-S-(2-oxopropyl)cysteine, and N-acetyl-3-[(2-oxopropyl)sulfinyl]alanine. These metabolites may be formed following oxidation of 1-bromopropane to 1-bromo-2-propanol and bromoacetone and following subsequent glutathione conjugation with either of these compounds. Rats pretreated with 1-aminobenzotriazole (ABT), a potent inhibitor of P450 excreted less in urine (?30%), exhaled as 14CO2 (?80%), or retained in liver (?90%), with a concomitant increase in radioactivity expired as VOC (?52%). Following ABT pretreatment, rat urinary metabolites were reduced in number from 10 to 1, N-acetyl-S-propylcysteine, which accounted for >90% of the total urinary radioactivity in ABT pretreated rats. Together, these data demonstrate a role for cytochrome P450 and glutathione in the dose-dependent metabolism and disposition of 1-BrP in the rat.

C.E. Garner; S.C.J. Sumner; J.G. Davis; J.P. Burgess; Y. Yueh; J. Demeter; Q. Zhan; J. Valentine; A.R. Jeffcoat; L.T. Burka; J.M. Mathews

2006-01-01T23:59:59.000Z

423

Metabolism and disposition of 1-bromopropane in rats and mice following inhalation or intravenous administration  

SciTech Connect (OSTI)

Workplace exposure to 1-bromopropane (1-BrP) can potentially occur during its use in spray adhesives, fats, waxes, and resins. 1-BrP may be used to replace ozone depleting solvents, resulting in an increase in its annual production in the US, which currently exceeds 1 million pounds. The potential for human exposure to 1-BrP and the reports of adverse effects associated with potential occupational exposure to high levels of 1-BrP have increased the need for the development of biomarkers of exposure and an improved understanding of 1-BrP metabolism and disposition. In this study, the factors influencing the disposition and biotransformation of 1-BrP were examined in male F344 rats and B6C3F1 mice following inhalation exposure (800 ppm) or intravenous administration (5, 20, and 100 mg/kg). [1,2,3-{sup 13}C]1-BrP and [1-{sup 14}C]1-BrP were administered to enable characterization of urinary metabolites using NMR spectroscopy, LC-MS/MS, and HPLC coupled radiochromatography. Exhaled breath volatile organic chemicals (VOC), exhaled CO{sub 2}, urine, feces, and tissues were collected for up to 48 h post-administration for determination of radioactivity distribution. Rats and mice exhaled a majority of the administered dose as either VOC (40-72%) or {sup 14}CO{sub 2} (10-30%). For rats, but not mice, the percentage of the dose exhaled as VOC increased between the mid ({approx} 50%) and high ({approx} 71%) dose groups; while the percentage of the dose exhaled as {sup 14}CO{sub 2} decreased (19 to 10%). The molar ratio of exhaled {sup 14}CO{sub 2} to total released bromide, which decreased as dose increased, demonstrated that the proportion of 1-BrP metabolized via oxidation relative to pathways dependent on glutathione conjugation is inversely proportional to dose in the rat. [{sup 14}C]1-BrP equivalents were recovered in urine (13-17%, rats; 14-23% mice), feces (< 2%), or retained in the tissues and carcass (< 6%) of rats and mice administered i.v. 5 to 100 mg/kg [{sup 14}C]1-BrP. Metabolites characterized in urine of rats and mice include N-acetyl-S-propylcysteine, N-acetyl-3-(propylsulfinyl)alanine, N-acetyl-S-(2-hydroxypropyl)cysteine, 1-bromo-2-hydroxypropane-O-glucuronide, N-acetyl-S-(2-oxopropyl)cysteine, and N-acetyl-3-[(2-oxopropyl)sulfinyl]alanine. These metabolites may be formed following oxidation of 1-bromopropane to 1-bromo-2-propanol and bromoacetone and following subsequent glutathione conjugation with either of these compounds. Rats pretreated with 1-aminobenzotriazole (ABT), a potent inhibitor of P450 excreted less in urine ({down_arrow}30%), exhaled as {sup 14}CO2 ({down_arrow}80%), or retained in liver ({down_arrow}90%), with a concomitant increase in radioactivity expired as VOC ({up_arrow}52%). Following ABT pretreatment, rat urinary metabolites were reduced in number from 10 to 1, N-acetyl-S-propylcysteine, which accounted for > 90% of the total urinary radioactivity in ABT pretreated rats. Together, these data demonstrate a role for cytochrome P450 and glutathione in the dose-dependent metabolism and disposition of 1-BrP in the rat.

Garner, C.E. [Department of Drug Metabolism and Disposition, RTI International, Research Triangle Park, NC 27709 (United States)]. E-mail: cegarner@rti.org; Sumner, S.C.J. [Department of Drug Metabolism and Disposition, RTI International, Research Triangle Park, NC 27709 (United States); Davis, J.G. [Department of Drug Metabolism and Disposition, RTI International, Research Triangle Park, NC 27709 (United States); Burgess, J.P. [Department of Drug Metabolism and Disposition, RTI International, Research Triangle Park, NC 27709 (United States); Yueh, Y. [Department of Drug Metabolism and Disposition, RTI International, Research Triangle Park, NC 27709 (United States); Demeter, J. [Department of Drug Metabolism and Disposition, RTI International, Research Triangle Park, NC 27709 (United States); Zhan, Q. [Department of Drug Metabolism and Disposition, RTI International, Research Triangle Park, NC 27709 (United States); Valentine, J. [Department of Drug Metabolism and Disposition, RTI International, Research Triangle Park, NC 27709 (United States); Jeffcoat, A.R. [Department of Drug Metabolism and Disposition, RTI International, Research Triangle Park, NC 27709 (United States); Burka, L.T. [National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 (United States); Mathews, J.M. [Department of Drug Metabolism and Disposition, RTI International, Research Triangle Park, NC 27709 (United States)

2006-08-15T23:59:59.000Z

424

Flow Cytometric Analysis of the Effect of Sodium Chloride on Gastric Cancer Risk in the Rat  

Science Journals Connector (OSTI)

...rats by gavage. Twenty-four h later, animals were...The mucosa appears to lift away from the underlying...weight at various time points after treatment with a...treatment at the earlier time points. Analysis of variance...cycle, at various time points after treat ment. Chart...

Gail Charnley and Steven R. Tannenbaum

1985-11-01T23:59:59.000Z

425

Lipogenic activity of some hepatic enzymes in rat : effects of dietary protein level, insulin and cortisol  

E-Print Network [OSTI]

Lipogenic activity of some hepatic enzymes in rat : effects of dietary protein level, insulin-DH), malic enzyme (ME), acetyl CoA carboxylase (Ac CoAcx) and fatty acid synthetase (FAS) was studied a minimum 8 days after the beginning of high protein intake. This low lipogenic enzyme activity level

Boyer, Edmond

426

Concomitant elevations in serum sialytransferase activity and sialic acid content in rats with metastasizing mammary tumors  

Science Journals Connector (OSTI)

...D. Kitts, Can. J. Anim. Sci. 41, 1 (1961); C. A. Alison and W. D. Kitts, J. Anim. Sci. 23, 1155 (1964). 6...tumors have reached 1 to 2 cm in average diameter, or as other-wise stated, the rats were anesthetized with ether and the tissues...

RJ Bernacki; U Kim

1977-02-11T23:59:59.000Z

427

Promotion of Growth and Differentiation of Rat Ductular Oval Cells in Primary Culture  

Science Journals Connector (OSTI)

...ad libitum until killing at 4 weeks (10). Production of Monoclonal...Components Hepatocytes (unli-lIKS ,).BALB/c mice were immunized...29). After 3, 6, and 9 weeks, IO6 hepatocytes in saline...isolated from rats maintained for 4 weeks on a 3'-Me- DAB diet by...

Lucie Germain; Micheline Nol; Henriette Gourdeau; and Normand Marceau

1988-01-15T23:59:59.000Z

428

Magnetic Injection of Nanoparticles into Rat Inner Ears at a Human Head Working Distance  

E-Print Network [OSTI]

t57 1 Magnetic Injection of Nanoparticles into Rat Inner Ears at a Human Head Working Distance: azeem@umd.edu Due to the physics of magnetic fields and forces, any single magnet will always attract or pull-in magnetically-responsive particles. However, there are a variety of clinical needs where

Shapiro, Benjamin

429

A biologically inspired meta-control navigation system for the Psikharpax rat robot  

Science Journals Connector (OSTI)

A biologically inspired navigation system for the mobile rat-like robot named Psikharpax is presented, allowing for self-localization and autonomous navigation in an initially unknown environment. The ability of parts of the model (e.g. the strategy selection mechanism) to reproduce rat behavioral data in various maze tasks has been validated before in simulations. But the capacity of the model to work on a real robot platform had not been tested. This paper presents our work on the implementation on the Psikharpax robot of two independent navigation strategies (a place-based planning strategy and a cue-guided taxon strategy) and a strategy selection meta-controller. We show how our robot can memorize which was the optimal strategy in each situation, by means of a reinforcement learning algorithm. Moreover, a context detector enables the controller to quickly adapt to changes in the environmentrecognized as new contextsand to restore previously acquired strategy preferences when a previously experienced context is recognized. This produces adaptivity closer to rat behavioral performance and constitutes a computational proposition of the role of the rat prefrontal cortex in strategy shifting. Moreover, such a brain-inspired meta-controller may provide an advancement for learning architectures in robotics.

K Caluwaerts; M Staffa; S N'Guyen; C Grand; L Doll; A Favre-Flix; B Girard; M Khamassi

2012-01-01T23:59:59.000Z

430

Loss of hippocampal theta rhythm results in spatial memory deficit in the rat  

Science Journals Connector (OSTI)

...N.V., J COMP PHYSL PSYCHOL 56 : 339 ( 1953 ). CONRAD, LCA, CONNECTIONS OF MEDIAN AND DORSAL RAPHE NUCLEI IN RAT - AUTORADIOGRAPHIC...and Education Administration of the U.S. Depart-ment of Agriculture (12-14-3001-758), and by the College of Agricultural...

J Winson

1978-07-14T23:59:59.000Z

431

Uptake and retention kinetics of para-fluorine-18-fluorobenzylguanidine in isolated rat heart  

SciTech Connect (OSTI)

Para-[{sup 18}F]fluorobenzylguanidine ([{sup 18}F]PFBG) is a newly developed tracer for imaging myocardial sympathetic neuronal innervation. This study investigated the uptake and retention mechanisms of [{sup 18}F]PFBG in perfused, isolated rat heart. 31 refs., 3 figs., 2 tabs.

Berry, C.R.; Garg, P.K.; Zalutsky, M.R. [North Carolina State Univ., Raleigh, NC (United States)]|[Duke Univ. Medical Center, Durham, NC (United States)] [and others

1996-12-01T23:59:59.000Z

432

Beneficial Effects of Hematopoietic Growth Factor Therapy in Chronic Ischemic Stroke in Rats  

E-Print Network [OSTI]

Beneficial Effects of Hematopoietic Growth Factor Therapy in Chronic Ischemic Stroke in Rats Li. Vania Apkarian, PhD; John A. Kessler, MD Background and Purpose--Stroke is the leading cause of adult disability worldwide. Currently, there is no effective treatment for stroke survivors. Stem cell factor (SCF

Apkarian, A. Vania

433

Establishing a rodent (Fischer 344 rat) model of mild cognitive impairment in aging  

E-Print Network [OSTI]

and memory deficits emerge in some people by middle-age while others remain largely cognitively-intact even at advanced chronological ages. The goal of this thesis is to establish a Fischer 344 (F344) rat model with some features of human cognitive aging...

LaSarge, Candi Lynn

2009-05-15T23:59:59.000Z

434

Effects of chronic cadmium exposure on the conditioned reinforcing properties of morphine and fentanyl in rats  

E-Print Network [OSTI]

. In these experiments adult male rats were exposed ad libitum for 40 days to 100 ppm cadmium chloride through their diet, or an identical diet with no added cadmium. CPP was conducted in a 2-chamber apparatus in which all drugs were paired with the least-preferred side...

Miller, Dennis K

2012-06-07T23:59:59.000Z

435

The effect of moderate alcohol intake on bone mineral density of ovariectomized rats  

E-Print Network [OSTI]

-week-old female rats were divided into six groups, four treatment and two control. Two of the treatment groups and one of the control groups underwent surgery to remove the ovaries in order to induce estrogen deficiency and simulate menopause. The treatment groups...

Shipley, Debra Lynn

2012-06-07T23:59:59.000Z

436

The effects of bicuculline on cocaine self-administration in male rats developmentally exposed to lead  

E-Print Network [OSTI]

: The present study examined the effects of perinatal lead-exposure on cocaine self-administration after a GABAA antagonist pre-treatment. Methods: Female rats were exposed to a regimen of 16 mg lead daily for 30 days prior to breeding with un-exposed males...

Valles, Rodrigo, Jr.

2004-09-30T23:59:59.000Z

437

Associative tolerance to nicotine analgesia in the rat: tail-flick and hot-plate assays  

E-Print Network [OSTI]

development phase, or both. In Experiment 1, Sprague-Dawley male rats (N = 32) were habituated to mock tests and then injected with various nicotine doses and tested for nociception. It was found that nicotine produced analgesia in a dose dependent manner...

Reynoso, Jose T.

2012-06-07T23:59:59.000Z

438

Behavioral Assays to Study Sensorimotor Deficit and Recovery in Rats Following Middle Cerebral Artery Occlusion  

E-Print Network [OSTI]

was to determine whether or not there is a correlation between performance during the corner test and ischemic volume. In this study, 16 acyclic (reproductively senescent) rats were used and assigned to one of two groups: one group received estrogen treatment after...

Roman-Cruz, Glorian M.

2010-07-14T23:59:59.000Z

439

Response of thymus lymphocytes to streptozotocin-induced diabetes and exogenous vitamin C administration in rats  

Science Journals Connector (OSTI)

......Hibino Y. Orally administrated ascorbic acid suppressed neuronal damage and modifies expression of SVCT2 and GLUT1 in the brain of diabetic rats with cerebral ischemia-reperfusion. Nutrients. (2014) 6:1554-1577. 41 Owu D U , Antai A B, Udofia......

Dil?ad Ozerkan,; Nesrin Ozsoy; Suna Cebesoy

2014-12-01T23:59:59.000Z

440

The Effects of Alcohol and Age on Astrocytes In Female Rats Following an Inflammatory Stimulus  

E-Print Network [OSTI]

------+ + + + + + + + + - - - + + + - - - MMP- 2 #0;? * Optica l Density Control Control+LPS Control+EtOH Control+LPS+EtOH Optica l Density Fig 6. MMP-2 lytic activity decreases in astrocytes derived from reproductive senescent female rats. LPS decreased MMP-2 lytic activity...

Simpson, Ashley

2009-09-30T23:59:59.000Z

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

A Glucose BioFuel Cell Implanted in Rats Philippe Cinquin1  

E-Print Network [OSTI]

A Glucose BioFuel Cell Implanted in Rats Philippe Cinquin1 *, Chantal Gondran2 , Fabien Giroud2 powerful ones, Glucose BioFuel Cells (GBFCs), are based on enzymes electrically wired by redox mediators applications. Citation: Cinquin P, Gondran C, Giroud F, Mazabrard S, Pellissier A, et al. (2010) A Glucose BioFuel

Paris-Sud XI, Université de

442

Rat injury model under controlled field-relevant primary blast conditions: Acute response to a wide  

E-Print Network [OSTI]

1 1 Rat injury model under controlled field-relevant primary blast conditions: Acute response.edu Keywords: Traumatic Brain Injury, Primary Blast, Mortality, Cellular Membrane Permeability, Lung Injury the risk of sustaining blast induced injury by military personnel and civilians. The blast injury

Farritor, Shane

443

Memantine Protects Rats Treated with Intrathecal Methotrexate from Developing Spatial Memory Deficits  

Science Journals Connector (OSTI)

...research-article Cancer Therapy: Preclinical Memantine Protects Rats Treated with Intrathecal...New York Purpose: To test whether memantine can prevent methotrexate-induced cognitive...methotrexate. We then tested whether memantine, an antagonist of the N-methyl-d-aspartate...

Peter D. Cole; Veena Vijayanathan; Nafeeza F. Ali; Mark E. Wagshul; Eric J. Tanenbaum; Jeremy Price; Vidhi Dalal; Maria E. Gulinello

2013-08-15T23:59:59.000Z

444

The adenovirus major late transcription factor activates the rat gamma-fibrinogen promoter  

Science Journals Connector (OSTI)

...lanes 2 and 7 to 12).-y-FBG mutants A-95, A-39, and A-24 were constructed by cloning the Bst XI/Bst EUI, Eco RI/Bst EUI, and Hae III/Bst EII fragment, respectively, of rat y-FBG into pUC18 by means of standard cloning procedures...

LA Chodosh; RW Carthew; JG Morgan; GR Crabtree; PA Sharp

1987-10-30T23:59:59.000Z

445

Regional Distribution of the Locomotor Pattern-Generating Network in the Neonatal Rat Spinal Cord  

E-Print Network [OSTI]

Regional Distribution of the Locomotor Pattern-Generating Network in the Neonatal Rat Spinal Cord K/NMA, and was evidence of a distributed organization of unit generators inmonitored via hindlimb flexor (peroneal, Winnipeg, Manitoba R3E 0W3, Canada Cowley, K. C. and B. J. Schmidt. Regional distribution of the rhythmic

Manitoba, University of

446

Comparative Analysis of the -Like Globin Clusters in Mouse, Rat, and Human Chromosomes Indicates a  

E-Print Network [OSTI]

to GenBank/EMBL under accession no. AY016022.] Genome sequencing projects and comparative genome analysesComparative Analysis of the -Like Globin Clusters in Mouse, Rat, and Human Chromosomes Indicates -globin pseudogene. Comparative sequence analysis with the functional -globin loci at human Chromosome 16p

Miller, Webb

447

Regression of Glioma in Rat Models by Intranasal Application of Parvovirus H-1  

Science Journals Connector (OSTI)

...digitized using a Leica DMRBE fluorescent microscope (Leica) equipped...infection of immunocompetent rats led to induction of H-1PV-neutralizing...indicated: (1) olfactory bulbs, (2) frontal cortex/caudate...signals). A, area of olfactory bulbs; B, tumor area; C, cerebellum...

Irina Kiprianova; Nadja Thomas; Ali Ayache; Manuel Fischer; Barbara Leuchs; Michle Klein; Jean Rommelaere; and Jrg R. Schlehofer

2011-08-15T23:59:59.000Z

448

Inhalation developmental toxicology studies: Teratology study of tetrahydrofuran in mice and rats: Final report  

SciTech Connect (OSTI)

Tetrahydrofuran (THF), a four-carbon cyclic ether, is widely used as an industrial solvent. Although it has been used in large quantities for many years, few long-term toxicology studies, and no reproductive or developmental studies, have been conducted on THF. This study addresses the potential for THF to cause developmental toxicity in rodents by exposing Sprague-Dawley rats and Swiss (CD-1) mice to 0, 600, 1800, or 5000 ppm tetrahydrofuran (THF) vapors, 6 h/day, 7 dy/wk. Each treatment group consisted of 10 virgin females (for comparison), and approx.33 positively mated rats or mice. Positively mated mice were exposed on days 6--17 of gestation (dg), and rats on 6--19 dg. The day of plug or sperm detection was designated as O dg. Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice (rats, 20 dg; mice, 18 dg). Implants were enumerated and their status recorded and live fetuses were examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. 27 refs., 6 figs., 23 tabs.

Mast, T.J.; Evanoff, J.J.; Stoney, K.H.; Westerberg, R.B.; Rommereim, R.L.; Weigel, R.J.

1988-08-01T23:59:59.000Z

449

Metabolism of 210Po in rats: volatile 210Po in excreta  

Science Journals Connector (OSTI)

......Laboratories, Atomic Energy of Canada Limited...as it emits high-energy alpha particles...stayed and in his own home. Release of volatile...Laboratories, Atomic Energy of Canada Limited...rat, their daily consumption of food and water...efficiency was 98.6 % (average of five replicates......

Chunsheng Li; Baki Sadi; Heather Wyatt; Michelle Bugden; Nicholas Priest; Diana Wilkinson; Gary H. Kramer

2010-07-01T23:59:59.000Z

450

Mineral bone composition and some elements of calcium metabolism in magnesium-deficient growing rats  

E-Print Network [OSTI]

Mineral bone composition and some elements of calcium metabolism in magnesium-deficient growing-Chomponelle, Theix, 63110 Beaumont, France. Summary. (1) Magnesium deficiency was induced in Sprague-Dawley male rats of deprivation. (3) The leg bones were fragmented as shown in figure 1. Their magnesium content had decreased

Paris-Sud XI, Université de

451

Effect of Cancer on the in Vivo Energy State of Rat Liver and Skeletal Muscle  

Science Journals Connector (OSTI)

...Effect of Cancer on the in Vivo Energy State of Rat Liver and Skeletal...Effects of fructose on the energy metabolism and acid-base status...Effect of fasting and acute ethanol administration on the energy state of in vivo liver as measured...

Alison L. Schneeberger; R. Terry Thompson; Albert A. Driedger; Richard J. Finley; and Richard I. Inculet

1989-03-01T23:59:59.000Z

452

Regulation of metabolism during lactation in the rat D. H. WILLIAMSON  

E-Print Network [OSTI]

the lactose and protein and a high proportion of the lipid con- tained in rat milk are synthesized within, in particular, milk production, appears to depend on two hormo- nes, prolactin and insulin. Secretion responsible for regula- tion of insulin secretion from the pancreas. The apparent paradox in lactation

Boyer, Edmond

453

Gender Differences in Transcriptional Signature of Developing Rat Testes and Ovaries following Embryonic  

E-Print Network [OSTI]

Dioxins are persistent organic pollutants interfering with endocrine systems and causing reproductive,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) on reproductive function of male and female offspring in the rat with a special fertility of the progeny. We choose a global gene expression approach using Affymetrix microarray analysis

Paris-Sud XI, Université de

454

Comparative morphology and tumourigenicity of human hepatocellular carcinoma cell lines in athymic rats and mice  

Science Journals Connector (OSTI)

Four human hepatoma cell lines PLC/PRF/5, Hep G2, Sk-Hep 1 and Mahlavu were inoculated subcutaneously into athymic Balb/c nude mice and N/NIH outbred nude rats, producing well encapsulated tumours. The 4 hepat...

Daniel Shouval; Lucia Schuger; Itzhak S. Levij; Lola M. Reid

1988-01-01T23:59:59.000Z

455

Identifying Neural Correlates of Tinnitus: Consequences of Acoustic Trauma on Inferior Colliculus Activity in Unanesthetized Rats  

E-Print Network [OSTI]

in spontaneous neural activity in the inferior colliculus of awake, freely moving rats following acoustic trauma. We were able to measure levels of spontaneous activity (SA) following acoustic trauma with the use of both single unit electrophysiology and 14C-2...

Kennon-McGill, Stefanie

2014-08-31T23:59:59.000Z

456

Level of osteopenia and bone recovery in alcohol-fed adolescent rats  

E-Print Network [OSTI]

consumption on young, actively growing adolescent bones have not been done. The objective of this study was to determine the level of bone recovery, if any, once an adolescent ceases alcohol consumption. Fifty, 4-week old, female, Sprague-Dawley rats were...

Spears, Heather Lynae

2012-06-07T23:59:59.000Z

457

Cache Decision Making: The Effects of Competition on Cache Decisions in Merriam's Kangaroo Rat (Dipodomys merriami)  

E-Print Network [OSTI]

Cache Decision Making: The Effects of Competition on Cache Decisions in Merriam's Kangaroo Rat (Dipodomys merriami) Stephanie D. Preston and Lucia F. Jacobs University of California, Berkeley Caching food the risk of pilferage. However, little is known about how food-storing animals determine the risk

Jacobs, Lucia

458

Cerebral perfusion and oxygenation are impaired by folate deficiency in rat: absolute measurements  

E-Print Network [OSTI]

Cerebral perfusion and oxygenation are impaired by folate deficiency in rat: absolute measurements University, Boston, Massachusetts, USA; 3 Institute of Biochemistry, Food Science and Nutrition, Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel

Fantini, Sergio

459

Chorda tympani nerve transection alters linoleic acid taste discrimination by male and female rats  

E-Print Network [OSTI]

Chorda tympani nerve transection alters linoleic acid taste discrimination by male and female rats in revised form 17 May 2006; accepted 8 June 2006 Abstract Taste is intimately associated with food choice foods. We measured the taste threshold for linoleic acid (LA), an essential free fatty acid found

Hull, Elaine

460

ORIGINAL INVESTIGATION Role of orexin/hypocretin in conditioned sucrose-seeking in rats  

E-Print Network [OSTI]

ORIGINAL INVESTIGATION Role of orexin/hypocretin in conditioned sucrose-seeking in rats Angie M-seeking, especially for highly salient food and drug rewards. We reasoned that this system may be strongly engaged during periods of reward restriction, includ- ing food restriction. Objectives This study examined

Aston-Jones, Gary

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Induced Hypothermia During Resuscitation from Hemorrhagic Shock Attenuates Microvascular Inflammation in the Rat Mesenteric Microcirculation  

E-Print Network [OSTI]

INDUCED HYPOTHERMIA DURING RESUSCITATION FROM HEMORRHAGIC SHOCK ATTENUATES MICROVASCULAR INFLAMMATION IN THE RAT MESENTERIC MICROCIRCULATION BY GARRETT NICHOLAS COYAN BS, UNIVERSITY OF MICHIGAN, 2009 Submitted to the graduate degree... program in Clinical Research and the Graduate Faculty of the University of Kansas in partial fulfillment of the requirements for the degree of Master of Science. ________________________________ Chairperson Edward F. Ellerbeck, MD, MPH...

Coyan, Garrett Nicholas

2013-08-31T23:59:59.000Z

462

Effects of dietary fat, fiber and carcinogen on fecal diacylglcyerols in the rat  

E-Print Network [OSTI]

of physiological modifiers such as diet and carcinogen on fecal DAG mass and composition have not been reported. We designed a 2 x 2 x 2 factorial study (2 fats: corn oil 'I and fish oil; 2 fibers: pectin and 'Cellulose; with and without carcinogen). Rats were...

Pickering, Jennifer Sharon

1996-01-01T23:59:59.000Z

463

Resveratrol improves ifosfamide-induced Fanconi syndrome in rats  

SciTech Connect (OSTI)

Regarding the mechanisms of ifosfamide (IFO)-induced urinary toxicity, several hypotheses have been put forward, among which oxidative stress and depletion of glutathione are suggested. This investigation elucidates the role of free radicals in IFO-induced toxicity and the protection by resveratrol, a natural phytoalexin. Wistar albino rats were injected intraperioneally with saline (0.9% NaCl; control), saline + resveratrol (RVT; 10 mg/kg/day), ifosfamide (IFO; 50 mg/kg/day) or IFO + RVT for 5 days. Urine was collected for 24 h during the 5th day, and at the 120th h after the first injections, animals were killed by decapitation and trunk blood was collected. Lactate dehydrogenase (LDH) activity, total antioxidant capacity (AOC) and pro-inflammatory cytokines TNF-{alpha}, IL-{beta} and IL-6 were assayed in plasma samples. Kidney and bladder tissues were obtained for biochemical and histological analysis. Formation of reactive oxygen species in the tissue samples was monitored by using chemiluminescence (CL) technique with luminol and lucigenin probes. The results demonstrated that IFO induced a Fanconi syndrome characterized by increased urinary sodium, phosphate, glucose and protein, along with increased serum creatinine and urea levels. On the other hand, RVT markedly ameliorated the severity of renal dysfunction induced by IFO. Furthermore IFO caused a significant decrease in plasma AOC, which was accompanied with significant increases in the levels of the pro-inflammatory mediators and LDH activity, while RVT treatment reversed all these biochemical indices. In the saline-treated IFO group, glutathione levels were decreased significantly, while the malondialdehyde levels, myeloperoxidase activity and collagen content were increased in both tissues, which were in parallel with the increases in CL values. In the RVT-treated IFO group, all of these oxidant responses were prevented significantly. Our results suggest that IFO causes oxidative damage in the renal and bladder tissues and resveratrol, via its antioxidant effects, protects these tissues. Therefore, its therapeutic role in preventing the development of chemotherapeutic drug-induced major toxicity in the urinary system requires further elucidation.

Sehirli, Ozer [Marmara University, School of Pharmacy, Department of Pharmacology, Tibbiye Cad. 34668 Istanbul (Turkey); Sakarcan, Abdullah [USC School of Medicine, Division of Pediatric Nephrology, Columbia, SC (United States); Velioglu-Oguenc, Ayliz [Marmara University, Vocational School of Health Related Professions, Istanbul (Turkey); Cetinel, Sule [Marmara University, School of Medicine, Department of Histology-Embryology, Istanbul (Turkey); Gedik, Nursal [Marmara University, School of Medicine, Department of Physiology, Istanbul (Turkey); Yegen, Berrak C. [Kasimpasa Military Hospital, Department of Biochemistry, Istanbul (Turkey); Sener, Goeksel [Marmara University, School of Pharmacy, Department of Pharmacology, Tibbiye Cad. 34668 Istanbul (Turkey)]. E-mail: gsener@marmara.edu.tr

2007-07-01T23:59:59.000Z

464

Studies on Pentoxifylline and Tocopherol Combination for Radiation-Induced Heart Disease in Rats  

SciTech Connect (OSTI)

Purpose: To investigate whether the application of pentoxifylline (PTX) and tocopherol l (Vit. E) could modify the development of radiation-induced heart disease and downregulate the expression of transforming growth factor (TGF)-{beta}1mRNA in rats. Methods and Materials: A total of 120 Sprague-Dawley rats were separated into four groups: control group, irradiated group, experimental group 1, and experiment group 2. Supplementation was started 3 days before irradiation; in experimental group 1, injection of PTX (15 mg/kg/d) and Vit. E (5.5 mg/kg/d) continued till the 12th week postirradiation, whereas in experimental group 2 it was continued until the 24th week postirradiation. All rats were administrated a single dose of 20 Gy irradiation to the heart except the control group. Histopathologic evaluation was performed at various time points (Days 1, 2, 4, 8, and 12 and 24th week) up to 24 weeks after irradiation. Changes of levels of TGF-{beta}1 mRNA expression were also investigated at the same time points using competitive polymerase chain reaction. Results: Compared with the irradiated group, levels of TGF-{beta}1 mRNA of the rat hearts were relatively low in the two experimental groups on the 12th week postirradiation. In experimental group 1, there was a rebound expression of TGF-{beta}1 mRNA on the 24th week postirradiation, whereas that of the experimental group 2 remained low (p < 0.05). The proportions of collagen fibers of the two experimental groups were lower than that of irradiated group (p < 0.05). A rebound could be observed in the experimental group 1. Conclusion: PTX and Vit. E downregulated the expression of TGF-{beta}1 mRNA. The irradiated rat hearts showed a marked pathologic response to the drugs. The withdrawal of drugs in the 12th week postirradiation could cause rebound effects of the development of fibrosis.

Liu Hui [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Xiong Mai [Department of Cardiac Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong (China); Xia Yunfei; Cui Nianji; Lu Rubiao [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Deng Ling [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Pathology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Lin Yuehao [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Clinical Laboratory, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Rong Tiehua [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Thoracic Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China)], E-mail: esophagus2003@yahoo.com.cn

2009-04-01T23:59:59.000Z

465

Myocardial kinetics of carbon-11-epinephrine in the isolated working rat heart  

SciTech Connect (OSTI)

The kinetics of EPI were studied in the isolated rat heart model to evaluate {sup 11}C-epinephrine (EPI) as a radiotracer for the assessment of sympathetic neuronal function in the heart. Isolated rat hearts were perfused in a working mode. Carbon-11-EPI was added to the perfusate during wash-in period of 20 min, followed by a washout period of 40 min. Radioactivity in the heart was externally monitored and time-activity curves were recorded as a function of time. Effluent samples were collected throughout each study to determine the fraction of {sup 11}C radioactivity as intact tracer. Time-activity curves of control hearts showed that {sup 11}C-EPI is taken up and retained by the myocardium. Desipramine inhibition (DMI) of uptake-1 resulted in a significant decrease in myocardial uptake and retention of {sup 11}C-EPI by 91% compared to controls. Addition of DMI to the perfusion medium during washout did not affect kinetics of {sup 11}C-EPI compared to control hearts. Reserpine pretreated rat hearts also showed significant decrease in tracer retention of 95% compared to controls. The metabolic data showed that, in control conditions, about 61% of {sup 11}C-EPI taken up by the rat heart is rapidly metabolized and released. Carbon-11-EPI traces sympathetic nerve terminals in the isolated rat heart. Uptake blockade by DMI and reserpine suggest that uptake and storage of {sup 11}C-EPI appear to be similar to that of norepinephrine. However, the prominent metabolic pathway warrants further consideration. These results suggest that {sup 11}C-EPI may be a suitable radiolabeled tracer for the evaluation of sympathetic vesicular function of the heart by PET. 23 refs., 3 figs., 3 tabs.

Nguyen, N.T.B.; DeGrado, T.R.; Chakraborty, P. [Univ. of Michigan, Ann Arbor, MI (United States)] [and others

1997-05-01T23:59:59.000Z

466

Study of the potential oxidative stress induced by six solvents in the rat brain  

Science Journals Connector (OSTI)

The mechanisms of action involved in the neurotoxicity of solvents are poorly understood. In vitro studies have suggested that the effects of some solvents might be due to the formation of reactive oxygen species (ROS). This study assesses hydroxyl radical (OH) generation and measures malondialdehyde (MDA) levels in the cerebral tissue of rats exposed to six solvents (n-hexane, n-octane, toluene, n-butylbenzene, cyclohexane and 1,2,4-trimethylcyclohexane). Three of these solvents have been shown to generate ROS in studies carried out in vitro on granular cell cultures from rat cerebellum. We assessed OH production by quantifying the rate of formation of 3,4-dihydroxybenzoic acid using a trapping agent, 4-hydroxybenzoic acid, infused via the microdialysis probe, into the prefrontal cortex of rats exposed intraperitoneally to the solvents. Extracellular MDA was quantified in microdialysates collected from the prefrontal cortex of rats exposed, 6h/day for ten days, to 1000ppm of the solvents (except for n-butylbenzene, generated at 830ppm) in inhalation chambers. Tissue levels of free and total MDA were measured in different brain structures for rats acutely (intraperitoneal route) and sub-acutely (inhalation) exposed to solvents. None of the six solvents studied increased the production of hydroxyl radicals in the prefrontal cortex after acute administration. Nor did they increase extracellular or tissue levels of MDA after 10 days inhalation exposure. On the other hand, a decrease in the concentrations of free MDA in brain structures was observed after acute administration of n-hexane, 1,2,4-trimethylcyclohexane, toluene and n-butylbenzene. Therefore, data of this study carried out in vivo did not confirm observations made in vitro on cell cultures.

Monique Chalansonnet; Nathalie Carabin; Stphane Boucard; Frdric Cosnier; Herv Nunge; Franois Gagnaire

2013-01-01T23:59:59.000Z

467

Aniline-induced nitrosative stress in rat spleen: Proteomic identification of nitrated proteins  

SciTech Connect (OSTI)

Aniline exposure is associated with toxicity to the spleen which is characterized by splenomegaly, hyperplasia, fibrosis, and a variety of sarcomas on chronic exposure in rats. However, mechanisms by which aniline elicits splenotoxic responses are not well understood. Earlier we have shown that aniline exposure leads to increased nitration of proteins in the spleen. However, nitrated proteins remain to be characterized. Therefore, in the current study using proteomic approaches, we focused on characterizing the nitrated proteins in the spleen of aniline-exposed rats. Aniline exposure led to increased tyrosine nitration of proteins, as determined by 2D Western blotting with anti-3-nitrotyrosine specific antibody, compared to the controls. The analyzed nitrated proteins were found in the molecular weight range of 27.7 to 123.6 kDa. A total of 37 nitrated proteins were identified in aniline-treated and control spleens. Among them, 25 were found only in aniline-treated rats, 11 were present in both aniline-treated and control rats, while one was found in controls only. The nitrated proteins identified mainly represent skeletal proteins, chaperones, ferric iron transporter, enzymes, nucleic acids binding protein, and signaling and protein synthesis pathways. Furthermore, aniline exposure led to significantly increased iNOS mRNA and protein expression in the spleen, suggesting its role in increased reactive nitrogen species formation and contribution to increased nitrated proteins. The identified nitrated proteins provide a global map to further investigate alterations in their structural and functional properties, which will lead to a better understanding of the role of protein nitration in aniline-mediated splenic toxicity. - Highlights: > Proteomic approaches are used to identify nitrated proteins in the spleen. > Twenty five nitrated proteins were found only in the spleen of aniline-treated rats. > Aniline exposure led to increased iNOS mRNA and protein expression in the spleen. > Results support the role of nitrosative stress in splenic toxicity of aniline.

Fan Xiuzhen; Wang Jianling [Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 (United States); Soman, Kizhake V. [Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 (United States); Ansari, G.A.S. [Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 (United States); Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 (United States); Khan, M. Firoze, E-mail: mfkhan@utmb.edu [Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 (United States)

2011-08-15T23:59:59.000Z

468

Age-related alterations in brain ?1-adrenoceptors of hypertensive rats: Their possible role in the development of arterial hypertensionof hypertensive rats: Their possible role in the development of arterial hypertension  

Science Journals Connector (OSTI)

The binding of labeled agonist (3H-prazosin) to ?1...-receptors in the frontal cortex, hypothalamus, and medulla oblongata of hypertensive (NISAG) and normotensive (Wistar) rats of different age is studied to elu...

G. T. Shishkina; A. L. Markel'

1995-07-01T23:59:59.000Z

469

Effect of theo-polyphenols ( ) on function of trans-membranous signal system of acute ischemic myocardium in rats) on function of trans-membranous signal system of acute ischemic myocardium in rats  

Science Journals Connector (OSTI)

Objective...: To observe the effect of theo-polyphenols (TP) on function of trans-membranous signal of acute ischemic myocardium in rats.Methods...: Model of myocardial ischemia was established. ...

Ke Yongsheng; Liu Zhaofang; Zhao Zhendong

1999-09-01T23:59:59.000Z

470

Periadolescent oral manganese exposure affects conditioned place preference by cocaine and conditioned place aversion by lithium chloride in rats  

E-Print Network [OSTI]

Manganese neurotoxicity compromises basal ganglia functions that could affect the limbic system and drug sensitivity. Male rats were orally exposed to manganese chloride (0, 100, 200 mg/kg/day Mn) for 15 days starting at postnatal day (PND) 28...

Lee, Samuel Ming Hin

2013-02-22T23:59:59.000Z

471

Quantifying the strain response in the rat tibia during simulated resistance training used as a disuse countermeasure  

E-Print Network [OSTI]

loss. This study used a hindlimb unloaded (HU) rat model to simulate microgravity and a muscle stimulation countermeasure to simulate resistive exercise. Uniaxial strain gages were implanted on the antero-medial aspect of the proximal tibia to measure...

Jeffery, Jay Melvin

2009-05-15T23:59:59.000Z

472

Quantifying the strain response in the rat tibia during simulated resistance training used as a disuse countermeasure  

E-Print Network [OSTI]

loss. This study used a hindlimb unloaded (HU) rat model to simulate microgravity and a muscle stimulation countermeasure to simulate resistive exercise. Uniaxial strain gages were implanted on the antero-medial aspect of the proximal tibia to measure...

Jeffery, Jay Melvin

2008-10-10T23:59:59.000Z

473

Creatine phosphate as energy source in the cerulein-stimulated rat pancreas study by31P nuclear magnetic resonance  

Science Journals Connector (OSTI)

Stimulation of the rat exocrine pancreas by cerulein induces a variety of cellular processes, some of which require the expenditure of energy. In this study, changes in the amounts of various energy metabolite...

S. Aired; Y. Creach; C. Palevody; J. Esclassan

1991-09-01T23:59:59.000Z

474

Retinal ganglion cell survival and axon regeneration in WldS transgenic rats after optic nerve crush and lens injury  

E-Print Network [OSTI]

Abstract Background We have previously shown that the slow Wallerian degeneration mutation, whilst delaying axonal degeneration after optic nerve crush, does not protect retinal ganglion cell (RGC) bodies in adult rats. To test the effects of a...

Lorber, Barbara; Tassoni, Alessia; Bull, Natalie D; Moschos, Marilita M; Martin, Keith R

2012-06-06T23:59:59.000Z

475

Memantine, amantadine, and L-deprenyl potentiate the action of L-DOPA in monoamine-depleted rats  

Science Journals Connector (OSTI)

Some treatments used for Parkinson's disease attenuate locomotor depression in rats treated with reserpine and ?-methyl-p-tyrosine. In the present study memantine (2.5, 5.0mg/kg), ... 100 mg/kg). At higher doses,...

G. Skuza; Z. Rogoz; G. Quack; W. Danysz

1994-01-01T23:59:59.000Z

476

Distribution of Liposomes into Brain and Rat Brain Tumor Models by Convection-Enhanced Delivery Monitored with Magnetic Resonance Imaging  

Science Journals Connector (OSTI)

...Convection-Enhanced Delivery Monitored with Magnetic Resonance Imaging Ryuta Saito...B, T 1-weighted coronal magnetic resonance image of a 9L-2 rat...assistance, Dr. David Newitt (Magnetic Resonance Science Center, University of California...

Ryuta Saito; John R. Bringas; Tracy R. McKnight; Michael F. Wendland; Christoph Mamot; Daryl C. Drummond; Dmitri B. Kirpotin; John W. Park; Mitchel S. Berger; and Krys S. Bankiewicz

2004-04-01T23:59:59.000Z

477

The effect of irradiation-induced hyposalivation on dental caries induction in rats fed high or low-sucrose diet  

Science Journals Connector (OSTI)

The effects of X-ray irradiation to the salivary glands on the induction of dental caries were examined in specific pathogen-free Sprague-Dawley rats fed either a high (containing 56% sucrose) or a low-sucrose...

Tatsuo Hashida D.D.S.; Ph. D.; Tadashi Sasai D.D.S.

1994-12-01T23:59:59.000Z

478

Hemodynamic responses in rat brain during transcranial direct current stimulation: a functional near-infrared spectroscopy study  

Science Journals Connector (OSTI)

In the present study, we monitored hemodynamic responses in rat brains during transcranial direct current stimulation (tDCS) using functional near-infrared spectroscopy (fNIRS). Seven...

Han, Chang-Hee; Song, Hyuna; Kang, Yong-Guk; Kim, Beop-Min; Im, Chang-Hwan

2014-01-01T23:59:59.000Z

479

The role of constrictor prostanoids in the development of aortic coarctation-induced hypertension in male and female rats  

E-Print Network [OSTI]

function and arterial blood pressure (MAP) during development of aortic coarctation-induced hypertension (HT). M and F rats, (15-18 wks.) in four groups: normotensive (NT), hypertensive (HT), ovariectomized (OVX), and OVX estrogen-replaced (OE), underwent...

Baltzer, Wendy Irene

2005-02-17T23:59:59.000Z

480

Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies  

Science Journals Connector (OSTI)

This review will summarize the pharmacological properties and physiological regulation of neuroactive steroids, with a particular focus on divergent neuroactive steroid responses to stress and ethanol in rats, mi...

Patrizia Porcu; A. Leslie Morrow

2014-09-01T23:59:59.000Z

Note: This page contains sample records for the topic "rat rattus norvegicus" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

The Effects of Habitat Fragmentation on the Behavior of the Cotton Rat (Sigmodon hispidus):Phase II  

SciTech Connect (OSTI)

The authors studied the movements of cotton rats and cotton mice in experimental landscapes at the SRS in order to determine the effects of fragmentation and connectivity between habitat patches on dispersal movements and population dynamics. Densities between connected and isolated patches were not different. Small patches tended to support higher densities. Cotton rats were more common in corridors than expected and cotton mice were more likely to leave by a corridor.

Barrett, G.W.; Drelin, E.A.; Mabry, K.E.

2001-07-01T23:59:59.000Z

482

Effects of whole-body irradiation on the development of Nippostrongylus brasiliensis (Travassos, 1914) Lane, 1923, in rats  

E-Print Network [OSTI]

EFFECTS OF WHOLE-BODY IRRADIATION ON THE DEVELOPMENT OF NIPPOSTRONGYLUS BSASILIENSIS (SSAVASSOS, 1414) LANE, 1923, IN RATS A Thesis By Gilbert Wayne Gatlin Submitted to the Graduate College of the Texas A&M University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE August 1966 Major Subject Zoolocay EFFECTS OF WHOLE-BODY IRRADIATION ON THE DEVELOPMENT OF NIPPOSTRONGYLUS ~SSASIEIEN IS (IlViVASSOS, 19144 LANE, 1923, IN RATS A Thesis By Gilbert Wayne Gatlin...

Gatlin, Gilbert Wayne

2012-06-07T23:59:59.000Z

483

The effect of temperature and oxygen level on the production of testosterone, androstenedione and progesterone by rat testis in vitro  

E-Print Network [OSTI]

THE EFFECT OF TEMPERATURE AND OXYGEN LEVEL ON THE PRODUCTION OF TESTOSTERONE, ANDROSTFNEDIONE AND PROGESTERONE BY RAT TESTIS IN VITRO A Thesis by PETER ANTHONY DUDLEY Submitted to the Graduate College of the Texas A%M University in partial... fulfillment of the requirements for the degree of MASTER OF SCIENCE January 1969 Major Subject: Physiology of Reproduction THE EFFECT OF TEMPERATURE AND OXYGEN LEVEL ON THE PRODUCTION OF TESTOSTERONE, ANDROSTENEDIONE AND PROGESTERONE BY RAT TESTIS...

Dudley, Peter Anthony

2012-06-07T23:59:59.000Z

484

Short term effects of commercial polychlorinated biphenyl (PCB) mixtures and individual PCB congeners in female Sprague-Dawley rats  

E-Print Network [OSTI]

SHORT TERM EFFECTS OF COMMERCIAL POLYCHLORINATED BIPHENYL (PCB) MIXTURFS AND INDIVIDUAL PCB CONGENERS IN FEMALE SPRAGUE-DAWLEY RATS A Thesis by YU-CHYU CHEN Submitted to the Office of Graduate Studies of Texas A&M University in partial... fulfillment of the requirements for the degree of MASTER OF SCIENCE December 1992 Major subject: Toxicology SHORT TERM EFFECTS OF COMMERCIAL POLYCHLORINATED BIPHENYL (PCB) MIXTURES AND INDIVIDUAL PCB CONGENERS IN FEMALE SPRAGUE-DAWLEY RATS A Thesis...

Chen, Yu-Chyu

2012-06-07T23:59:59.000Z

485

Development of [11C]MFTC for PET Imaging of Fatty Acid Amide Hydrolase in Rat and Monkey Brains  

Science Journals Connector (OSTI)

Development of [11C]MFTC for PET Imaging of Fatty Acid Amide Hydrolase in Rat and Monkey Brains ... Positron emission tomography (PET) summation images of rat brains showed high radioactivity in the frontal cortex, cerebellum, and hippocampus, which was consistent with the regional distribution pattern of FAAH in rodent brain. ... Pretreatment with MFTC or FAAH-selective URB597 significantly reduced the uptake in the brain. ...

Katsushi Kumata; Joji Yui; Akiko Hatori; Jun Maeda; Lin Xie; Masanao Ogawa; Tomoteru Yamasaki; Yuji Nagai; Yoko Shimoda; Masayuki Fujinaga; Kazunori Kawamura; Ming-Rong Zhang

2014-11-14T23:59:59.000Z

486

Effect of the environmental enrichment on the severity of psychological dependence and voluntary methamphetamine consumption in methamphetamine withdrawn rats  

Science Journals Connector (OSTI)

Abstract Previously results have been shown that chronic methamphetamine causes dependence, withdrawal syndrome and drug craving. Also, environmental enrichment (EE) has been shown protective effects in several animal models of addiction. This study evaluated effect of the EE on the anxiety-depression profile and voluntary METH consumption in METH-dependent rats after abstinence. The rats were chronically treated with bi-daily doses (2mg/kg, at 12h intervals) of METH over a period of 14 days. METH dependent rats reared in standard environment (SE) or EE during spontaneous METH withdrawal which lasted 30 days. Then, the rats were tested for anxiety (the elevated plus maze-EPM) and depression (forced swim test-FST) and also voluntary consumption of METH using a two-bottle choice paradigm (TBC). The results showed that the EE rats exhibited an increase in EPM open arm time and entries (Prats than the SE group during 2 periods of the intake of drug (P<0.05). Environmental enrichment seems to be one of the strategies in reduction of behavioral deficits and the risk of relapse induced by METH withdrawal.

Samira Hajheidari; Hossein Miladi-Gorji; Imanollah Bigdeli

2015-01-01T23:59:59.000Z

487

Blood risk factor metabolites associated with heart disease and myocardial fatty acids in copper-deficient male and female rats  

SciTech Connect (OSTI)

Intact and castrated males and intact and ovariectomized female rats were fed a copper-deficient diet in order to establish whether the protection provided in females against cardiovascular pathology and mortality is due to endogenous sex hormones, and different levels of blood lipids and/or myocardial fatty acids. Seventy-three male and female rats were assigned to a copper-deficient diet (0.6 {mu}g of copper/g diet) containing 62% fructose for 8 weeks. Twelve of the male rats underwent castration and 12 of the females were ovariectomized. All animals exhibited high levels of plasma cholesterol, triglycerides, and uric acid, which were neither affected by the sex of the rat nor by the surgical treatment. The composition of fatty acids of the myocardium was similar in males and females. Except for those animals that were sacrificed by us, all other male rats died of heart pathology. In contrast, none of the female rats exhibited heart pathology and none died of the deficiency. It is suggested that heart pathology and mortality in copper deficiency are sex related and not due to high levels of plasma cholesterol, triglycerides, and uric acid or to differences in myocardial fatty acid composition.

Fields, M.; Lewis, C.; Beal, T. (Georgetown Univ. Medical School, WA (USA)); Berlin, E.; Kliman, P.G.; Peters, R.C. (Department of Agriculture, Beltsville, MD (USA))

1989-07-01T23:59:59.000Z

488

Effects of Resistance Trainging and -hydroxy--methylbutyrate (HMB) on Muscle Fiber CSA and Lean Body Mass in Aged Rats: A DTI and DEXA Study  

E-Print Network [OSTI]

Body Mass in Aged Rats: A DTI and DEXA Study I. S. Masad1,2 , Y-M. Park3 , S-R. Lee3 , J. M. Wilson3 strength and lean body mass (LBM) [7, 8], were investigated in a pre-clinical model of aged rats during resistance training (RT). Methods: Experimental setup: Sixteen 19-month-old Sprague-Dawley female rats were

McQuade, D. Tyler

489

Rat parotid cell function in vitro following x irradiation in vivo  

SciTech Connect (OSTI)

The effect of X irradiation on rat parotid acinar cell function was evaluated in vitro 1, 3, and 7 days following in vivo exposure to 2000 R. Several cellular functions were followed: protein secretion (amylase release), ion movement (K/sup +/ efflux and reuptake), amino acid transport (..cap alpha..-amino(/sup 14/C)isobutyric acid), and an intermediary metabolic response ((/sup 14/C)glucose oxidation). In addition both the morphologic appearance and in vivo saliva secretory ability of parotid cells were assessed. Our results demonstrate that surviving rat parotid acinar cells, isolated and studied in vitro 1-7 days following 2000 R, remain functionally intact despite in vivo diminution of secretory function.

Bodner, L.; Kuyatt, B.L.; Hand, A.R.; Baum, B.J.

1984-02-01T23:59:59.000Z

490

Effect of nonylphenol on male reproduction: Analysis of rat epididymal biochemical markers and antioxidant defense enzymes  

SciTech Connect (OSTI)

The mechanism by which nonylphenol (NP) interferes with male reproduction is not fully elucidated. Therefore, the present study was conducted to evaluate the effect of NP on male reproductive organ's weight, sperm characteristics, and to elucidate the nature and mechanism of action of NP on the epididymis. Adult male Wistar rats were gavaged with NP, dissolved in corn oil, at 0, 100, 200 or 300 mg/kg/day for 30 consecutive days. Control rats were gavaged with vehicle (corn oil) alone. Body weight did not show any significant change while, absolute testes and epididymides weights were significantly decreased. Sperm count in cauda and caput/corpus epididymides, and sperm motility was significantly decreased. Daily sperm production was significantly decreased in a dose-related manner. Sperm transit time in cauda epididymis was significantly decreased by 300 mg/kg, while in the caput/corpus epididymis it was significantly decreased by 200 and 300 mg/kg of NP. Plasma LDH was significantly increased while; plasma testosterone was significantly decreased in a dose-related pattern. In the epididymal sperm, NP decreased acrosome integrity, ??m and 5?-nucleotidase activity. Hydrogen peroxide (H{sub 2}O{sub 2}) production and LPO were significantly increased in a dose-related pattern. The activities of SOD, CAT and GPx were significantly decreased in the epididymal sperm. In conclusion, this study revealed that NP treatment impairs spermatogenesis and has a cytotoxic effect on epididymal sperm. It disrupts the prooxidant and antioxidant balance. This leads oxidative stress in epididymal sperms of rat. Moreover, the reduction in sperm transit time may affect sperm quality and fertility potential. -- Highlights: ? The nature and mechanism of action of NP on rat epididymis were elucidated. ? NP decreased sperm count, motility, daily sperm production and sperm transit time. ? NP decreased sperm acrosome integrity, ??m and 5?-nucleotidase activity. ? Plasma LDH was significantly increased and testosterone was significantly decreased. ? NP induced oxidative stress in epididymal sperm.

Aly, Hamdy A.A., E-mail: hamdyaali@yahoo.com [Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah (Saudi Arabia); Domnech, scar [Department of Physical Chemistry, Faculty of Pharmacy, Barcelona University (Spain)] [Department of Physical Chemistry, Faculty of Pharmacy, Barcelona University (Spain); Banjar, Zainy M. [Department of Medical Biology, School of Medicine, King Abdulaziz University, Jeddah (Saudi Arabia)] [Department of Medical Biology, School of Medicine, King Abdulaziz University, Jeddah (Saudi Arabia)

2012-06-01T23:59:59.000Z

491

The postnatal development of the sex organs in prenatally and early postnatally irradiated male albino rats  

E-Print Network [OSTI]

days of age and a sub- sequent regeneration between 105 and 185 days of age. Beaumont (1962) reported that in males receiving 100r X-rays on gestational day 17. 5, which corresponds very closely with day 18 irradiates in this study, it 41 appeared.... Bagg concludes, "the results so far indicate that gamma-ray irradiation is a physical agent adapted to the study of experimentally produced developmental arrests in mammalian embryos. " Hanson (1922) reported that male albino rats which were...

Ricks, Robert Clinton

1964-01-01T23:59:59.000Z

492

Effect of freezing on the coupling of VIP receptors to adenylate cyclase in rat liver membranes  

SciTech Connect (OSTI)

In fresh rat liver plasma membranes high affinity VIP receptors were specifically labelled with (/sup 125/I) helodermin and were well coupled to adenylate cyclase while low affinity VIP receptors were not. After freezing and thawing low affinity VIP receptors were also coupled to adenylate cyclase. This modification of adenylate cyclase activation was specific for the VIP response as freezing and thawing did not modify Gpp(NH)p, NaF and glucagon stimulations. 26 references, 3 figures, 1 table.

Robberecht, P.; Waelbroeck, M.; De Neef, P.; Camus, J.C.; Gourlet, P.; Christophe, J.

1988-01-01T23:59:59.000Z

493

Inhalation of 1-Bromopropane Causes Excitation in the Central Nervous System of Male F344 Rats  

Science Journals Connector (OSTI)

The present study investigates the effects of 1-bromopropane (1BP) on animal behavior to determine the extent of toxicity to the central nervous system (CNS). We measured the spontaneous locomotor activity (SLA) of rats before and after 3 weeks of exposure to 1BP for 8h per day. In control and 10ppm groups, the SLA values were similar to pre-exposure levels on post-exposure Day 1 and thereafter. However, the SLA values in the 50 and 200ppm groups were higher than pre-exposure levels. Open-field behavior was evaluated after exposure and freezing time decreased with exposure to increasing concentrations of 1BP. Ambulation and rearing scores in the exposed groups were higher than control values, particularly in the 50 and 200ppm groups. The frequency of defecation and urination decreased almost dose-dependently. Exposure to 501000ppm of 1BP did not affect passive avoidance behavior examined using a step-through type apparatus. The amount of time swimming in the water maze test was not affected in the controls, or groups exposed to 50 and 200ppm 1BP, but that in the 1000ppm group was increased compared with control. Exposure at 501000ppm dose-dependently decreased the traction performance of rats, indicating decreased muscle strength. We found that 10200ppm of 1BP exposure did not affect motor coordination determined by rota-rod performance. The increased SLA values and open-field activity support the notion that 1BP has excitatory effects on the CNS of F344 male rats. In addition, 1BP reduced the grip or muscle strength of the rats. Memory function was not disordered and the motor coordination of all four limbs remained normal.

Takeshi Honma; Megumi Suda; Muneyuki Miyagawa

2003-01-01T23:59:59.000Z

494

Changes in neurotransmitter receptor expression levels in rat brain after 4-week exposure to 1-bromopropane  

Science Journals Connector (OSTI)

1-Bromopropane (1-BP), an alternative to ozone-depleting solvents, exhibits neurotoxicity and reproductive toxicity in animals and humans. The present study investigated the effects of exposure to 1-BP on expression of neurotransmitter receptor genes in the rat brain to explore possible biomarkers for central neurotoxicity and find brain regions sensitive for microarray analysis. Thirty-six F344 rats were divided at random into four equal groups of nine and exposed to 1-BP at 0, 400, 800 and 1000ppm for 8h/day; 7 days/week for 4 weeks. Total RNA from different brain regions was extracted and real-time PCR was conducted to quantify the mRNA levels of serotonin, dopamine and GABA receptors. Western blot analysis for specific regions of interest was also carried out to determine the protein levels. The mRNAs of 5HTr2a, D2R and \\{GABAa1\\} were down regulated in a 1-BP dose-dependent manner in the hippocampus. The mRNA levels of 5HTr1a, 5HTr2a, D1R and \\{GABAa1\\} were significantly decreased in the cortex of rats exposed to 800ppm, but not to 1000ppm. The mRNAs of 5HTr1a and 5HTr3a in the pons-medulla were decreased in rats exposed to 400ppm or higher concentrations. The mRNA expression of D2R in the hippocampus and 5HTr1a and 5HTr3a in the pons-medulla oblongata were the most sensitive indicators of 1-BP neurotoxicity. The results suggest that mRNA expression analysis is useful in identifying brain regions susceptible to 1-BP, as well as providing potential biomarkers for central nervous system toxicity.

Sahabudeen Sheik Mohideen; Sahoko Ichihara; Shameema Banu; Fang Liu; Junzoh Kitoh; Gaku Ichihara

2009-01-01T23:59:59.000Z

495

Collateral circulation prevents masticatory muscle impairment in rat middle cerebral artery occlusion model  

Science Journals Connector (OSTI)

The rat suture middle cerebral artery occlusion (MCAO) is a frequently used animal model for investigating the mechanisms of ischemic brain injury. During suture MCAO, transection of the external carotid artery (ECA) potentially restrains blood flow and impairs masticatory muscle and other ECA-supported territories, consequently influencing post-operation animal survival. This study investigates the effect of ECA transection on the hemodynamic alterations using a novel synchrotron radiation angiography technique and magnetic resonance imaging.

Yuan, F.

2014-10-01T23:59:59.000Z

496

Lipidomic changes in rat liver after long-term exposure to ethanol  

SciTech Connect (OSTI)

Alcoholic liver disease (ALD) is a serious health problem with significant morbidity and mortality. In this study we examined the progression of ALD along with lipidomic changes in rats fed ethanol for 2 and 3 months to understand the mechanism, and identify possible biomarkers. Male Fischer 344 rats were fed 5% ethanol or caloric equivalent of maltose-dextrin in a Lieber-DeCarli diet. Animals were killed at the end of 2 and 3 months and plasma and livers were collected. Portions of the liver were fixed for histological and immunohistological studies. Plasma and the liver lipids were extracted and analyzed by nuclear magnetic resonance (NMR) spectroscopy. A time dependent fatty infiltration was observed in the livers of ethanol-fed rats. Mild inflammation and oxidative stress were observed in some ethanol-fed rats at 3 months. The multivariate and principal component analysis of proton and phosphorus NMR spectroscopy data of extracted lipids from the plasma and livers showed segregation of ethanol-fed groups from the pair-fed controls. Significant hepatic lipids that were increased by ethanol exposure included fatty acids and triglycerides, whereas phosphatidylcholine (PC) decreased. However, both free fatty acids and PC decreased in the plasma. In liver lipids unsaturation of fatty acyl chains increased, contrary to plasma, where it decreased. Our studies confirm that over-accumulation of lipids in ethanol-induced liver steatosis accompanied by mild inflammation on long duration of ethanol exposure. Identified metabolic profile using NMR lipidomics could be further explored to establish biomarker signatures representing the etiopathogenesis, progression and/or severity of ALD. - Highlights: > Long term exposure to ethanol was studied. > A nuclear magnetic resonance (NMR) spectroscopy based lipidomic approach was used. > We examined the clustering pattern of the NMR data with principal component analysis. > NMR data were compared with histology and immunohistochemistry data. > Biochemical parameters were compared with the observed NMR lipid data.

Fernando, Harshica; Bhopale, Kamlesh K. [Department of Pathology, University of Texas Medical Branch, Galveston, TX, 77555 (United States); Kondraganti, Shakuntala [Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, 77555 (United States); Kaphalia, Bhupendra S. [Department of Pathology, University of Texas Medical Branch, Galveston, TX, 77555 (United States); Shakeel Ansari, G.A., E-mail: sansari@utmb.edu [Department of Pathology, University of Texas Medical Branch, Galveston, TX, 77555 (United States); Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, 77555 (United States)

2011-09-01T23:59:59.000Z

497

Herbal Formula-3 inhibits food allergy in rats by stabilizing mast cells through modulating calcium mobilization  

Science Journals Connector (OSTI)

AbstractBackground The prevalence of food allergy has increased dramatically during the last three decades, but currently there was no effective therapy except avoidance of allergen. This study aimed to investigate the effect of a modified Chinese herbal formula, Formula-3, on mast cell degranulation and the anti-allergic activity in both animal and cell models. Methods With OVA-sensitized food allergic model in BrownNorway rats, we checked tissue injury in the small intestines by H&E staining. The Th2 cytokine levels and IgE production in serum or supernatant of the intestinal mucosa homogenates were analyzed by ELISA. Meanwhile, rat peritoneal mast cell activation and degranulation were examined by Toluidine Blue Stain and the release of histamine was measured. Furthermore, the regulation of Formula-3 on Ca2+ mobilization was investigated by probing intracellular Ca2+ with fluo-4 fluorescence. The direct effect of Formula-3 on mast cell stabilization was also studied in RBL-2H3 cell line. Results In vivo Formula-3 administration significantly reduced tissue damage in the small intestines of rat and suppressed Th2 cytokine secretion and IgE production. We demonstrated that Formula-3 treatment significantly suppressed Fc?R1-mediated mast cell degranulation no matter in OVA-challenged allergic rats or IgE-sensitized RBL-2H3 cell line. Furthermore, Formula-3 significantly decreased Ca2+ influx through store-operated calcium channels (SOCs) evoked by dinitrophenyl-BSA or thapsigargin in mast cells. Conclusion Taken together, our data indicate that Formula-3 stabilizes mast cells by suppressing Fc?R1-induced Ca2+ mobilization mainly through inhibiting Ca2+ entry via SOCs, thus exerting a protective effect against OVA-sensitized food allergy.

Bo Yang; Jianjie Li; Xiaoyu Liu; Li Ma; Li Deng; Jie Liu; Zhigang Liu; Qiongmei Ji

2013-01-01T23:59:59.000Z

498

Vaccination protects rats from methamphetamine-induced impairment of behavioral responding for food  

Science Journals Connector (OSTI)

Abstract (+)-Methamphetamine (METH) addiction is a chronic disease that interferes with fundamental brain-mediated behaviors and biological functions like eating. These studies present preclinical efficacy and safety profiles for a METH conjugate vaccine (ICKLH-SMO9) designed to treat METH abuse. ICKLH-SMO9 efficacy and safety were assessed over a 16-week period by monitoring general health and stability of responding in a food maintained behavioral paradigm. Male SpragueDawley rats were trained to lever press for food reinforcers until stable behavior was established. Rats (n=9/group) were then immunized with 100?g of a control antigenic carrier protein (ICKLH-Cys) or ICKLH-SMO9 in Alhydrogel adjuvant, with booster immunizations at 4, 8 and 12weeks. Health, immunization site and behavior were assessed daily. No adverse effects were found. During weeks 1416, when antibody titers and METH affinity (Kd=13.91.7nM) were maximal, all rats received progressively higher METH doses (0.33.0mg/kg) every 34days, followed by behavioral testing. Even though the lower METH doses from 0.3 to 1.0mg/kg produced no impairment in food maintained behavior, 3.0-mg/kg in control rats showed significantly (p<0.05) reduced response rates and number of reinforcers earned, as well as reduced food intake. In sharp contrast, the ICKLH-SMO9 group showed no changes in food maintained behavior at any METH dose, even though METH serum concentrations showed profound increases due to anti-METH antibody binding. These findings suggest the ICKLH-SMO9 vaccine is effective and safe at reducing adverse METH-induced effects, even at high METH doses.

Daniela Redi-Bettschen; Sherri L. Wood; Melinda G. Gunnell; C. Michael West; Rama R. Pidaparthi; F. Ivy Carroll; Bruce E. Blough; S. Michael Owens

2013-01-01T23:59:59.000Z

499

The CCKB antagonist CI988 reduces food intake in fasted rats via a dopamine mediated pathway  

Science Journals Connector (OSTI)

Studies have shown a reduction of food intake following peripheral and brain injection of CCK. However, it remains to be established whether endogenous central CCK is involved in the regulation of food intake. We investigated the role of central CCK in the regulation of food intake by pharmacological manipulation of the CCKB (CCK2) receptor system. Intracerebroventricularly (ICV) cannulated male Sprague Dawley rats were fasted for 24h and received an ICV injection of the CCKB receptor antagonist CI988 at a dose of 10nmol or 49nmol or vehicle. Another group received two consecutive ICV injections consisting of the corticotropin-releasing factor (CRF) receptor-1 (CRF1) antagonist, CP376395 (3nmol) or the CRF2 receptor antagonist, K41498 (2nmol) alone, or followed by CI988 (49nmol). Lastly, another group of rats received an intraperitoneal (IP) injection of the dopamine antagonist, flupentixol (?197 and ?493nmol/kg) alone, or followed by CI988 (49nmol, ICV). Cumulative food intake was assessed for 11h. Vehicle injected rats showed a robust feeding response. CI988 at 49nmol reduced food intake by 30% starting at 2h post injection. CP376395 and K41498 had no effect on food intake. Flupentixol injected IP at a dose of 197 and 493nmol/kg alone did not modulate food intake whereas the higher dose blocked the CI988-induced reduction of feeding. During the dark phase, CI988 had no effect on food intake in unfasted rats. In summary, CCKB signaling is involved in the regulation of food intake after a fast likely by downstream dopamine signaling.

Lisa Frommelt; Vanessa Lembke; Tobias Hofmann; Miriam Goebel-Stengel; Hubert Mnnikes; Bertram Wiedenmann; Burghard F. Klapp; Andreas Stengel; Peter Kobelt

2013-01-01T23:59:59.000Z

500

Impulsive-choice patterns for food in genetically lean and obese Zucker rats  

Science Journals Connector (OSTI)

Behavioral-economic studies have shown that differences between lean and obese Zuckers in food consumption depend on the response requirement for food. Since a response requirement inherently increases the delay to reinforcement, differences in sensitivity to delay may also be a relevant mechanism of food consumption in the obese Zucker rat. Furthermore, the endocannabinoid neurotransmitter system has been implicated in impulsivity, but studies that attempt to characterize the effects of cannabinoid drugs (e.g., rimonabant) on impulsive choice may be limited by floor effects. The present study aimed to characterize impulsive-choice patterns for sucrose using an adjusting-delay procedure in genetically lean and obese Zuckers. Ten lean and ten obese Zucker rats chose between one lever that resulted in one pellet after a standard delay (either 1s or 5s) and a second lever that resulted in two or three pellets after an adjusting delay. After behavior stabilized under baseline, rimonabant (010mg/kg) was administered prior to some choice sessions in the two-pellet condition. Under baseline, obese Zuckers made more impulsive choices than leans in three of the four standard-delay/pellet conditions. Additionally, in the 2-pellet condition, rimonabant increased impulsive choice in lean rats in the 1-s standard-delay condition; however, rimonabant decreased impulsive choice in obese rats in the 1-s and 5-s standard-delay conditions. These data suggest that genetic factors that influence impulsive choice are stronger in some choice conditions than others, and that the endocannabinoid system may be a relevant neuromechanism.

Steven R. Boomhower; Erin B. Rasmussen; Tiffany S. Doherty

2013-01-01T23:59:59.000Z