Sample records for rat neth er

  1. Large-scale Nanostructure Simulations from X-ray Scattering Data On Graphics Processor Clusters

    E-Print Network [OSTI]

    Sarje, Abhinav

    2012-01-01T23:59:59.000Z

    X-ray Scattering Data On Graphics Processor Clusters Abhinavaccelerators. General purpose graphics processors o?er ?nethe form factors on graphics processors. Form Factor Kernel

  2. OoEr

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarlyEnergyDepartment ofDepartment ofof EnergyYou$0.C. 20545 OCT 28 1% - :NEW;ORAU 89/K-79OoEr 1325.8

  3. Estrogen receptor alpha 36 (ER-36) and other novel spliced ERs are widely expressed in ER-66-negative breast tumors

    E-Print Network [OSTI]

    of ER are examined using qPCR in ER-negative cell lines MCF7 MDA-MB-231 SKBR3 MCF7/218 (MC-20)(F-10-66-neagtive SKBR3 cells and ER-66-positive MCF7/218cells. A novel spliced form of ER is detected by WB using anti-ER(MC-20) antibody in ER-66- negative MDA-MB-231 and SKBR3 cell lines. 4. A novel

  4. Protein folding in the ER.

    SciTech Connect (OSTI)

    Stevens, F. J.; Argon, Y.; Biosciences Division; Univ. of Chicago

    1999-10-01T23:59:59.000Z

    The endoplasmic reticulum (ER) is a major protein folding compartment for secreted, plasma membrane and organelle proteins. Each of these newly-synthesized polypeptides folds in a deterministic process, affected by the unique conditions that exist in the ER. An understanding of protein folding in the ER is a fundamental biomolecular challenge at two levels. The first level addresses how the amino acid sequence programs that polypeptide to efficiently arrive at a particular fold out of a multitude of alternatives, and how different sequences obtain similar folds. At the second level are the issues introduced by folding not in the cytosol, but in the ER, including the risk of aggregation in a molecularly crowded environment, accommodation of post-translational modifications and the compatibility with subsequent intracellular trafficking. This review discusses both the physicochemical and cell biological constraints of folding, which are the challenges that the ER molecular chaperones help overcome.

  5. BIOENERGI ER BLEVET MODERNE 4DECEMBER 2003

    E-Print Network [OSTI]

    at bruge biomasse til energi. Opfyring med brænde og opvarmning med halmfyr eller biogas er kendte, biogas og bioethanol. Bioenergi er den eneste vedvarende energikilde, der findes i fast, flydende og

  6. Energy and Society ER100/PPC184/ER200/PPC284, Fall 2014

    E-Print Network [OSTI]

    Kammen, Daniel M.

    of the process. If the article comes from New York Times, Wall Street Journal, Economist, Time, etc Timeliness1 Energy and Society ER100/PPC184/ER200/PPC284, Fall 2014 Problem Set #2 Total Points: 100 for ER100/PPC184 120 for ER200/PPC284 Topics covered: Energy and development, Combustion, Exponential growth

  7. af biobraendsler er: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Society (ER100PP184ER200PP284) Topics: Personal energy audit, the grid, nuclear, fracking Renewable Energy Websites Summary: Energy and Society (ER100PP184ER200PP284)...

  8. Tank 241-ER-311, grab samples, ER311-98-1, ER311-98-2, ER311-98-3 analytical results for the final report

    SciTech Connect (OSTI)

    FULLER, R.K.

    1999-02-24T23:59:59.000Z

    This document is the final report for catch tank 241-ER-311 grab samples. Three grab samples ER311-98-1, ER311-98-2 and ER311-98-3 were taken from East riser of tank 241-ER-311 on August 4, 1998 and received by the 222-S Laboratory on August 4, 1998. Analyses were performed in accordance with the Compatibility Grab Sampling and Analysis Plan (TSAP) (Sasaki, 1998)and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) (Mulkey and Miller, 1997). The analytical results are presented in the data summary report (Table 1). No notification limits were exceeded.

  9. Energy and Society (ER100/PP184/ER200/PP284) Topics: Personal energy audit, the grid, nuclear, fracking

    E-Print Network [OSTI]

    Kammen, Daniel M.

    Energy and Society (ER100/PP184/ER200/PP284) Topics: Personal energy audit, the grid, nuclear and Society (ER100/PP184/ER200/PP284) Topics: Personal energy audit, the grid, nuclear, fracking Due Nov. 7 [ER100/PP184], 120 [ER200/PP284] Personal Energy Audit [40 POINTS TOTAL] How much energy do you

  10. Two-quasiparticle structures and isomers in {sup 168}Er, {sup 170}Er, and {sup 172}Er

    SciTech Connect (OSTI)

    Dracoulis, G. D.; Lane, G. J. [Department of Nuclear Physics, R.S.P.E, Australian National University, Canberra ACT 0200 (Australia); Kondev, F. G.; Chiara, C. J. [Nuclear Engineering Division, Argonne National Laboratory, Argonne, Illinois 60439 (United States); Watanabe, H. [RIKEN Nishina Center, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Seweryniak, D.; Zhu, S.; Carpenter, M. P.; Janssens, R. V. F.; Lauritsen, T.; Lister, C. J.; McCutchan, E. A. [Physics Division, Argonne National Laboratory, Argonne, Illinois 60439 (United States); Stefanescu, I. [Physics Division, Argonne National Laboratory, Argonne, Illinois 60439 (United States); Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742 (United States)

    2010-05-15T23:59:59.000Z

    The stable and neutron-rich isotopes {sup 168}Er, {sup 170}Er, and {sup 172}Er have been studied with Gammasphere using inelastic excitation with energetic {sup 136}Xe beams. The previously assigned structures based on the proposed K{sup p}i=4{sup -} isomeric intrinsic states in both {sup 168}Er and {sup 170}Er have been re-evaluated and an equivalent band identified in {sup 172}Er. In {sup 170}Er, the identification of a K{sup p}i=6{sup -} band with transitions close in energy to those of the 4{sup -} band leads to a modified interpretation, since the overlap would have compromised previous analyses. The g{sub K}-g{sub R} values for the 4{sup -} bands deduced from the in-band gamma-ray intensities for the sequence of isotopes suggest a predominantly two-neutron configuration in {sup 168}Er, an equally mixed two-neutron, two-proton configuration in {sup 170}Er, and a two-proton configuration in {sup 172}Er. A comprehensive decay scheme for the previously proposed 6{sup +} isomer in {sup 172}Er has also been established, as well as band structures built on this isomer that closely resemble the 6{sup +} and 7{sup -} two-neutron structures known in the isotone {sup 174}Yb. The implied K hindrances are discussed. The main decay path of the 6{sup +} isomer occurs through the newly identified 4{sup -} isomer. The measured lifetimes of the 4{sup -} and 6{sup +} isomers in {sup 172}Er are 57(3) and 822(90) ns, respectively. Multiquasiparticle calculations support the suggested configuration changes across the isotopic chain.

  11. Solstrling er temaet i denne boka. Alt liv er avhengig av solstrling sola gir liv, og sola er

    E-Print Network [OSTI]

    Sahay, Sundeep

    #12;Solstrling er temaet i denne boka. Alt liv er avhengig av solstrling sola gir liv, og sola solstrlingens betydning for vr helse og gi en naturfaglig bakgrunn for hvordan en br styre sine solvaner. Sola de viktigste, og at det innebrer en strre risiko hvis en ikke lar sola skinne p kroppen. I

  12. Energy and Society (ER100/PP184/ER200/PP284) Topics: PV, Wind, environmental justice

    E-Print Network [OSTI]

    Kammen, Daniel M.

    Energy and Society (ER100/PP184/ER200/PP284) Topics: PV, Wind, environmental justice Due Nov. 21 [ER200/PP284] - 1 - 1. Comparing PV costs across the US [24 points] In this question we are going to compare the costs of generating electricity using solar energy in different parts of the United States. a

  13. Ternary Dy-Er-Al magnetic refrigerants

    DOE Patents [OSTI]

    Gschneidner, K.A. Jr.; Takeya, Hiroyuki

    1995-07-25T23:59:59.000Z

    A ternary magnetic refrigerant material comprising (Dy{sub 1{minus}x}Er{sub x})Al{sub 2} for a magnetic refrigerator using the Joule-Brayton thermodynamic cycle spanning a temperature range from about 60K to about 10K, which can be adjusted by changing the Dy to Er ratio of the refrigerant. 29 figs.

  14. Ternary Dy-Er-Al magnetic refrigerants

    DOE Patents [OSTI]

    Gschneidner, Jr., Karl A. (Ames, IA); Takeya, Hiroyuki (Ibaraki, JP)

    1995-07-25T23:59:59.000Z

    A ternary magnetic refrigerant material comprising (Dy.sub.1-x Er.sub.x)Al.sub.2 for a magnetic refrigerator using the Joule-Brayton thermodynamic cycle spanning a temperature range from about 60K to about 10K, which can be adjusted by changing the Dy to Er ratio of the refrigerant.

  15. Energy and Society (ER100/PP184/ER200/PP284) Topics: Personal energy audit, nuclear, fracking, LCA

    E-Print Network [OSTI]

    Kammen, Daniel M.

    Energy and Society (ER100/PP184/ER200/PP284) Topics: Personal energy audit, nuclear, fracking, LCA and Society (ER100/PP184/ER200/PP284) Topics: Personal energy audit, nuclear, fracking, LCA Due Nov. 6100/PP184], 105 [ER200/PP284] Personal Energy Audit [40 POINTS TOTAL] How much energy do you consume

  16. Characterization of the ER stress checkpoint in mammalian cells

    E-Print Network [OSTI]

    Chen, Meifan

    2011-01-01T23:59:59.000Z

    role in oxidative protein folding in the endoplasmiccellular demand for protein folding and ER capacity has beenlipids. To ensure proper protein folding within the ER, the

  17. An ab initio-based ErHe interatomic potential in hcp Er

    SciTech Connect (OSTI)

    Yang, Li; ye, Yeting; Fan, K. M.; Shen, Huahai; Peng, Shuming; Long, XG; Zhou, X. S.; Zu, Xiaotao; Gao, Fei

    2014-09-01T23:59:59.000Z

    We have developed an empirical erbium-helium (Er-He) potential by fitting to the results calculated from ab initio method. Based on the electronic hybridization between Er and He atoms, an s-band model, along with a repulsive pair potential, has been derived to describe the Er-He interaction. The atomic configurations and the formation energies of single He defects, small He interstitial clusters (Hen) and He-vacancy (HenV ) clusters obtained by ab initio calculations are used as the fitting database. The binding energies and relative stabilities of the HnVm clusters are studied by the present potential and compared with the ab initio calculations. The Er-He potential is also applied to study the migration of He in hcp-Er at different temperatures, and He clustering is found to occur at 600 K in hcp Er crystal, which may be due to the anisotropic migration behavior of He interstitials.

  18. ARM CLASIC ER2 CRS/EDOP

    SciTech Connect (OSTI)

    Gerald Heymsfield

    2010-12-20T23:59:59.000Z

    Data was taken with the NASA ER-2 aircraft with the Cloud Radar System and other instruments in conjunction with the DOE ARM CLASIC field campaign. The flights were near the SGP site in north Central Oklahoma and targeted small developing convection. The CRS is a 94 GHz nadir pointing Doppler radar. Also on board the ER-2 was the Cloud Physics Lidar (CPL). Seven science flights were conducted but the weather conditions did not cooperate in that there was neither developing convection, or there was heavy rain.

  19. Low temperature properties of some Er-rich intermetallic compounds

    SciTech Connect (OSTI)

    K.A. Gshneidner,jr; A.O. Pecharsky; L.Hale; V.K. Pecharsky

    2004-09-30T23:59:59.000Z

    The low temperature volumetric heat capacity ({approx}3.5 to 350 K) and magnetic susceptibility ({approx}4 to 320 K) of Er{sub 3}Rh, Er{sub 3}Ir, Er{sub 3}Pt, Er{sub 2}Al, and Er{sub 2}Sn have been measured. All of the compounds order antiferromagnetically (or ferrimagnetically), and most exhibit more than one magnetic ordering transition. The volumetric heat capacities in general are smaller than those of the prototype magnetic regenerator materials, except for Er{sub 3}Ir in the 12 to 14 K temperature range.

  20. DOE/ER-0214 February 1985

    E-Print Network [OSTI]

    DOE/ER-0214 Magnetic Program Fusion Plan February 1985 U.S. Department of Energy Office of Energy Research Washington, D.C. 20585 #12;U.S. DEPARTMENT OF ENERGY Office of Energy Research February 1985, available resources, and the nation's need for future energy sources. #12;PREFACE During the past few years

  1. Kenya (Rpublique du) Admission 1 er

    E-Print Network [OSTI]

    Montréal, Université de

    2014-04-14 Kenya (République du) Admission 1 er cycle Programmes à capacité d'accueil limitée : complément d'informations Seuils requis selon les programmes Détails sur le test Kenya Certificate

  2. Unique ER Cistromes Control Cell Type-Specific Gene Regulation

    E-Print Network [OSTI]

    Brown, Myles

    -specific E2 regulation of gene expression in MCF7 and U2OS- ER cells, we compared the ER binding sites on DNA a critical role in defining the ER cistrome in MCF7 cells, it is not expressed in U2OS-ER cells, and forkhead-specific effects, however, remains to be explained. We have compared the gene expres- sion profile of the MCF7

  3. Rotational band properties in {sup 165}Er

    SciTech Connect (OSTI)

    Wang, S. T. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Graduate University of Chinese Academy of Sciences, Beijing 100049 (China); Zhou, X. H.; Zhang, Y. H.; Zheng, Y.; Liu, M. L.; Chen, L.; Zhang, N. T.; Hua, W.; Guo, S.; Qiang, Y. H.; Li, G. S.; Ding, B. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Shi, Y.; Xu, F. R. [School of Physics, and State Key Laboratory of Nuclear Physics and Technology, Peking University, Beijing 100871 (China)

    2011-07-15T23:59:59.000Z

    High-spin states in {sup 165}Er have been studied experimentally using the {sup 160}Gd({sup 9}Be, 4n) reaction at beam energies of 42 and 45 MeV. The previously known bands based on the 5/2{sup +}[642], 5/2{sup -}[523], and 11/2{sup -}[505] configurations are extended to (49/2{sup +}), (45/2{sup -}), and (31/2{sup -}) states, respectively. The rotational bands in {sup 165}Er generally show gradual alignment processes, indicating strong band interactions associated with the i{sub 13/2} neutron alignments. The band properties are compared with those in the neighboring nuclei and discussed within the framework of the cranked shell model.

  4. ER-12-1 completion report

    SciTech Connect (OSTI)

    Russell, C.E.; Gillespie, D.; Cole, J.C.; Drellack, S.L. [and others

    1996-12-01T23:59:59.000Z

    The objective of drillhole ER-12-1 was to determine the hydrogeology of paleozoic carbonate rocks and of the Eleana Formation, a regional aquitard, in an area potentially downgradient from underground nuclear testing conducted in nearby Rainier Mesa. This objective was addressed through the drilling of well ER-12-1 at N886,640.26 E640,538.85 Nevada Central Coordinates. Drilling of the 1094 m (3588 ft) well began on July 19, 1991 and was completed on October 17, 1991. Drilling problems included hole deviation and hole instability that prevented the timely completion of this borehole. Drilling methods used include rotary tri-cone and rotary hammer drilling with conventional and reverse circulation using air/water, air/foam (Davis mix), and bentonite mud. Geologic cuttings and geophysical logs were obtained from the well. The rocks penetrated by the ER-12-1 drillhole are a complex assemblage of Silurian, Devonian, and Mississippian sedimentary rocks that are bounded by numerous faults that show substantial stratigraphic offset. The final 7.3 m (24 ft) of this hole penetrated an unusual intrusive rock of Cretaceous age. The geology of this borehole was substantially different from that expected, with the Tongue Wash Fault encountered at a much shallower depth, paleozoic rocks shuffled out of stratigraphic sequence, and the presence of an altered biotite-rich microporphyritic igneous rock at the bottom of the borehole. Conodont CAI analyses and rock pyrolysis analyses indicate that the carbonate rocks in ER-12-1, as well as the intervening sheets of Eleana siltstone, have been thermally overprinted following movement on the faults that separate them. The probable source of heat for this thermal disturbance is the microporphyritic intrusion encountered at the bottom of the hole, and its age establishes that the major fault activity must have occurred prior to 102.3+0.5 Ma (middle Cretaceous).

  5. DOE/ER--0547T DE92

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinan antagonist Journal Article: Crystal structureComposite-- Energy,Converting to5994DOEFinal ReportER--0547T

  6. ER85773 | netl.doe.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed NewcatalystNeutronEnvironment >Dange1·DangerEPADetection R. De Souza 1ER85773

  7. Energy and Society (ER100/PP184/ER200/PP284) Topics: PV, Wind, environmental justice

    E-Print Network [OSTI]

    Kammen, Daniel M.

    ? [2 points] ii. [ER200/PP286 only] Relative to using average utility rates, how could time-of-use (TOU. How might our results for the levelized cost of PV electricity differ if we were considering utility-scale installations instead of residential-scale rooftop installations? List and explain three other factors we would

  8. IOWA STAT-er CHATTER Winter 2009/2010

    E-Print Network [OSTI]

    ://main.acsevents.org/site/TR/RelayForLife/ RFLFY10MW?team_id=568827&pg=team&fr_id= 22852 Intramural Sports Update Mark McKelvey The STAT-ers wereIOWA STAT-er CHATTER Winter 2009/2010 "All The 's That's Fit to Print" 1 From the Office of the President Lisa Bramer This summer began an exciting new era for the STAT-ers as Snedecor Hall

  9. An Improved Algorithm for Quanti er Elimination Over Real Closed ...

    E-Print Network [OSTI]

    assumption that each polynomial in the input depend ..... We call this procedure uniform quanti er elim- .... and describe the inputs, outputs and complexities of.

  10. Final Technical Report for Award # ER64999

    SciTech Connect (OSTI)

    Metcalf, William W. [University of Illinois

    2014-10-08T23:59:59.000Z

    This report provides a summary of activities for Award # ER64999, a Genomes to Life Project funded by the Office of Science, Basic Energy Research. The project was entitled "Methanogenic archaea and the global carbon cycle: a systems biology approach to the study of Methanosarcina species". The long-term goal of this multi-investigator project was the creation of integrated, multiscale models that accurately and quantitatively predict the role of Methanosarcina species in the global carbon cycle under dynamic environmental conditions. To achieve these goals we pursed four specific aims: (1) genome sequencing of numerous members of the Order Methanosarcinales, (2) identification of genomic sources of phenotypic variation through in silico comparative genomics, (3) elucidation of the transcriptional networks of two Methanosarcina species, and (4) development of comprehensive metabolic network models for characterized strains to address the question of how metabolic models scale with genetic distance.

  11. Comparative activation of estrogen receptor alpha (er alpha) by endocrine disruptors

    E-Print Network [OSTI]

    Wu, Fei

    2009-05-15T23:59:59.000Z

    -dependent,. These results demonstrate that various ER ligands differentially activate ER? in breast cancer cells and transgenic mice, and their activities are dependent on ER? variants, promoter-, cell-context and selective use of different Sp proteins, suggesting...

  12. Electron spin resonance study of Er-concentration effect in GaAs;Er,O containing charge carriers

    SciTech Connect (OSTI)

    Elmasry, F. [Graduate School of Science, Kobe University, 1-1 Rokkodai-cho, Nada, Kobe 657-8501 (Japan); Okubo, S. [Molecular Photoscience Research Center, Kobe University, 1-1 Rokkodai-cho, Nada, Kobe 657-8501 (Japan); Ohta, H., E-mail: hoht@kobe-u.ac.jp [Graduate School of Science, Kobe University, 1-1 Rokkodai-cho, Nada, Kobe 657-8501 (Japan); Molecular Photoscience Research Center, Kobe University, 1-1 Rokkodai-cho, Nada, Kobe 657-8501 (Japan); Fujiwara, Y. [Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871 (Japan)

    2014-05-21T23:59:59.000Z

    Er-concentration effect in GaAs;Er,O containing charge carriers (n-type, high resistance, p-type) has been studied by X-band Electron spin resonance (ESR) at low temperature (4.7?K?Er,O without carrier. The local structure around Er-2O centers is not affected by carriers because similar angular dependence of g-values was observed in both cases (with/without carrier). For temperature dependence, linewidth and lineshape analysis suggested the existence of Er dimers with antiferromagnetic exchange interaction of about 7?K. Moreover, drastic decrease of ESR intensity for C signal in p-type sample was observed and it correlates with the decrease of photoluminescence (PL) intensity. Possible model for the Er-2O trap level in GaAs:Er,O is discussed from the ESR and PL experimental results.

  13. RATS VERSUS PEOPLE Rats equal twice

    E-Print Network [OSTI]

    from rats to man and to other animals. Amebiasis, infectious jaun- dice, Salmonella food poison- ing, and tapeworm infections are spread by rats. The germs are transmitted to man by polluted_food and water. Rat. Rats will gnaw through almost anything in their path to obtain food. Hard substances ~ like concrete

  14. Balanced Ero1 activation and inactivation establishes ER redox homeostasis

    E-Print Network [OSTI]

    Kim, Sunghwan

    The endoplasmic reticulum (ER) provides an environment optimized for oxidative protein folding through the action of Ero1p, which generates disulfide bonds, and Pdi1p, which receives disulfide bonds from Ero1p and transfers ...

  15. Ozone induces glucose intolerance and systemic metabolic effects in young and aged brown Norway rats

    SciTech Connect (OSTI)

    Bass, V. [Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Gordon, C.J.; Jarema, K.A.; MacPhail, R.C. [Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Cascio, W.E. [Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Phillips, P.M. [Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Ledbetter, A.D.; Schladweiler, M.C. [Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Andrews, D. [Research Cores Unit, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Miller, D. [Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC (United States); Doerfler, D.L. [Research Cores Unit, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Kodavanti, U.P., E-mail: kodavanti.urmila@epa.gov [Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States)

    2013-12-15T23:59:59.000Z

    Air pollutants have been associated with increased diabetes in humans. We hypothesized that ozone would impair glucose homeostasis by altering insulin signaling and/or endoplasmic reticular (ER) stress in young and aged rats. One, 4, 12, and 24 month old Brown Norway (BN) rats were exposed to air or ozone, 0.25 or 1.0 ppm, 6 h/day for 2 days (acute) or 2 d/week for 13 weeks (subchronic). Additionally, 4 month old rats were exposed to air or 1.0 ppm ozone, 6 h/day for 1 or 2 days (time-course). Glucose tolerance tests (GTT) were performed immediately after exposure. Serum and tissue biomarkers were analyzed 18 h after final ozone for acute and subchronic studies, and immediately after each day of exposure in the time-course study. Age-related glucose intolerance and increases in metabolic biomarkers were apparent at baseline. Acute ozone caused hyperglycemia and glucose intolerance in rats of all ages. Ozone-induced glucose intolerance was reduced in rats exposed for 13 weeks. Acute, but not subchronic ozone increased ?{sub 2}-macroglobulin, adiponectin and osteopontin. Time-course analysis indicated glucose intolerance at days 1 and 2 (2 > 1), and a recovery 18 h post ozone. Leptin increased day 1 and epinephrine at all times after ozone. Ozone tended to decrease phosphorylated insulin receptor substrate-1 in liver and adipose tissues. ER stress appeared to be the consequence of ozone induced acute metabolic impairment since transcriptional markers of ER stress increased only after 2 days of ozone. In conclusion, acute ozone exposure induces marked systemic metabolic impairments in BN rats of all ages, likely through sympathetic stimulation. - Highlights: Air pollutants have been associated with increased diabetes in humans. Acute ozone exposure produces profound metabolic alterations in rats. Age influences metabolic risk factors in aging BN rats. Acute metabolic effects are reversible and repeated exposure reduces these effects. Ozone metabolic effects are only slightly exacerbated in geriatric rats.

  16. Opiate activity in the rat prefrontal cortex: modulation of ventral tegmental area dopaminergic influence on cortical efferent neurons

    E-Print Network [OSTI]

    St. Mary, John Steven

    1986-01-01T23:59:59.000Z

    OPIATE ACTIVITY IN THE RAT PREFRONTAL CORTEX: MODULATION OF VENTRAL TEGMENTAL AREA DOPAMINERGIC INFLUENCE ON CORTICAL EFFERENT NEURONS A Thesis by JOHN STEVEN ST. MARY Submitted to the Graduate College of Texas A&M University in partial... Thesis by JOHN STEVEN ST. MARY Approved as to style and content by: Steven Peterson (Chairman of Committee) Robert Matthews (- '" j'pj") Ger a ((~Fe g (Mem er) George Chion (Member) December 1986 ABSTRACT Opiate Activity in the Rat...

  17. Coordination of Endoplasmic Reticulum (ER) Signaling During Maize Seed Development

    SciTech Connect (OSTI)

    Boston, Rebecca S.

    2010-11-20T23:59:59.000Z

    Seed storage reserves represent one of the most important sources of renewable fixed carbon and nitrogen found in nature. Seeds are well-adapted for diverting metabolic resources to synthesize storage proteins as well as enzymes and structural proteins needed for their transport and packaging into membrane bound storage protein bodies. Our underlying hypothesis is that the endoplasmic reticulum (ER) stress response provides the critical cellular control of metabolic flux required for optimal accumulation of storage reserves in seeds. This highly conserved response is a cellular mechanism to monitor the protein folding environment of the ER and restore homeostasis in the presence of unfolded or misfolded proteins. In seeds, deposition of storage proteins in protein bodies is a highly specialized process that takes place even in the presence of mutant proteins that no longer fold and package properly. The capacity of the ER to deposit these aberrant proteins in protein bodies during a period that extends several weeks provides an excellent model for deconvoluting the ER stress response of plants. We have focused in this project on the means by which the ER senses and responds to functional perturbations and the underlying intracellular communication that occurs among biosynthetic, trafficking and degradative pathways for proteins during seed development.

  18. ER=EPR, GHZ, and the Consistency of Quantum Measurements

    E-Print Network [OSTI]

    Susskind, Leonard

    2014-01-01T23:59:59.000Z

    This paper illustrates various aspects of the ER=EPR conjecture.It begins with a brief heuristic argument, using the Ryu-Takayanagi correspondence, for why entanglement between black holes implies the existence of Einstein-Rosen bridges. The main part of the paper addresses a fundamental question: Is ER=EPR consistent with the standard postulates of quantum mechanics? Naively it seems to lead to an inconsistency between observations made on entangled systems by different observers. The resolution of the paradox lies in the properties of multiple black holes, entangled in the Greenberger-Horne-Zeilinger pattern. The last part of the paper is about entanglement as a resource for quantum communication. ER=EPR provides a way to visualize protocols like quantum teleportation. In some sense teleportation takes place through the wormhole, but as usual, classical communication is necessary to complete the protocol.

  19. ER=EPR, GHZ, and the Consistency of Quantum Measurements

    E-Print Network [OSTI]

    Leonard Susskind

    2014-12-29T23:59:59.000Z

    This paper illustrates various aspects of the ER=EPR conjecture.It begins with a brief heuristic argument, using the Ryu-Takayanagi correspondence, for why entanglement between black holes implies the existence of Einstein-Rosen bridges. The main part of the paper addresses a fundamental question: Is ER=EPR consistent with the standard postulates of quantum mechanics? Naively it seems to lead to an inconsistency between observations made on entangled systems by different observers. The resolution of the paradox lies in the properties of multiple black holes, entangled in the Greenberger-Horne-Zeilinger pattern. The last part of the paper is about entanglement as a resource for quantum communication. ER=EPR provides a way to visualize protocols like quantum teleportation. In some sense teleportation takes place through the wormhole, but as usual, classical communication is necessary to complete the protocol.

  20. Pahute Mesa Well Development and Testing Analyses for Wells ER-20-7, ER-20-8 #2, and ER-EC-11, Revision 1

    SciTech Connect (OSTI)

    Greg Ruskauff

    2011-12-01T23:59:59.000Z

    This report analyzes the following data collected from ER-20-7, ER-20-8 No.2, and ER-EC-11 during WDT operations: (1) Chemical indicators of well development (Section 2.0); (2) Static hydraulic head (Section 3.0); (3) Radiochemistry and geochemistry (Section 4.0); (4) Drawdown observed at locations distal to the pumping well (Section 5.0); and (5) Drilling water production, flow logs, and temperature logs (Section 6.0). The new data are further considered with respect to existing data as to how they enhance or change interpretations of groundwater flow and transport, and an interim small-scale conceptual model is also developed and compared to Phase I concepts. The purpose of well development is to remove drilling fluids and drilling-associated fines from the formation adjacent to a well so samples reflecting ambient groundwater water quality can be collected, and to restore hydraulic properties near the well bore. Drilling fluids can contaminate environmental samples from the well, resulting in nonrepresentative measurements. Both drilling fluids and preexisting fines in the formation adjacent to the well can impede the flow of water from the formation to the well, creating artifacts in hydraulic response data measured in the well.

  1. TALN 2011, Montpellier, 27 juin --1er juillet 2011

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    TALN 2011, Montpellier, 27 juin -- 1er juillet 2011 Développement de ressources pour le persan.fr Résumé. Nous présentons une nouvelle version de PerLex, lexique morphologique du persan, une nouvel étique- teur morphosyntaxique librement disponible pour le persan. Après avoir développé une

  2. ALGEBRA LINEAL I 1er Curso de CC. Fisicas.

    E-Print Network [OSTI]

    Guijarro, Luis

    ALGEBRA LINEAL I 1er Curso de CC. Fisicas. Examen Final. 4 de Febrero de 2008. Apellidos: Nombre subespacio complementario de S1 S2. 4. Hallar la matriz en la base canonica de una aplicacion lineal f : R

  3. Economic Impact Report BInghamton UnIvERsIty

    E-Print Network [OSTI]

    Suzuki, Masatsugu

    Economic Impact Report 2007 #12;BInghamton UnIvERsIty 8:1 return on investment The term "return will be returned to the state economy and $6 to the local economy -- delivering an economic impact of $8.65 billion as an engine of economic growth that improves the financial health of our region and state. EconomIc Impact

  4. Video Entity Resolution: Applying ER Techniques for Smart Video Surveillance

    E-Print Network [OSTI]

    Kalashnikov, Dmitri V.

    buildings, smart grid, and so on. In this paper, we focus on smart surveillance systems wherein video improvements on how the building is used. One of the key challenges in building smart surveillance systemsVideo Entity Resolution: Applying ER Techniques for Smart Video Surveillance Liyan Zhang Ronen

  5. ERS 14.2 Emissions Monitoring, 4/3/95 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    ERS 14.2 Emissions Monitoring, 4395 ERS 14.2 Emissions Monitoring, 4395 The objective of this surveillance is to verify that the contractor is monitoring emissions of...

  6. Requirements for ER reorganization and proliferation by HMG-CoA reductase

    E-Print Network [OSTI]

    Federovitch, Christine Marie

    2007-01-01T23:59:59.000Z

    the ER overload response or EOR. It was discovered as acharacteristic of both UPR and EOR, lending some credenceto the idea that EOR may be involved in some types of ER

  7. ER Membrane Protein Complex Required for Nuclear Fusion Davis T.W. Ng and Peter Walter

    E-Print Network [OSTI]

    Walter, Peter

    ER Membrane Protein Complex Required for Nuclear Fusion Davis T.W. Ng and Peter Walter Department is localized to the luminal (i.e., noncytoplasmic) face of the ER mem- brane, yet nuclear fusion must initiate of Sec63p, Sec71p, and Sec72p plays a central role in mediating nuclear mem- brane fusion and requires ER

  8. In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases

    E-Print Network [OSTI]

    Hebert, Daniel N.

    In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases 1377 C. Protein folding 1378 II. Protein Translocation, Folding, and Quality Control in the Endoplasmic Reticulum 1379 A. Protein targeting to the ER 1379 B. Chaperone-assisted protein folding in the ER 1379 C

  9. TALN 2011, Montpellier, 27 juin --1er juillet 2011

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    TALN 2011, Montpellier, 27 juin -- 1er juillet 2011 Développement de ressources pour le persan : le persan, une version corrigée et partiellement réannotée du corpus étiqueté BijanKhan (BijanKhan, 2004) et MEltfa, un nouvel étiqueteur morphosyntaxique librement disponible pour le persan. Après avoir développé

  10. ALGEBRA LINEAL I 1er Curso de CC. Fisicas.

    E-Print Network [OSTI]

    Guijarro, Luis

    ALGEBRA LINEAL I 1er Curso de CC. Fisicas. Examen Extraordinario. 14 de Septiembre de 2006 un vector u perpendicular a L. b) Hallar la matriz de la aplicacion lineal f : R3 R3 consistente en la simetria ortogonal respecto al plano de ecuacion 2x+y = 0. (Se trata de la aplicacion lineal

  11. ALGEBRA LINEAL I 1er Curso de CC. Fisicas.

    E-Print Network [OSTI]

    Guijarro, Luis

    ALGEBRA LINEAL I 1er Curso de CC. Fisicas. Examen Final. 9 de Febrero de 2006. Apellidos: Nombrex2 +10 = 0. 2. Dado el sistema de ecuaciones lineales: x -y +2z = 2 x +y -z = 1 2x +az = c 3x +y +bz la base canonica de R2 de una aplicacion lineal de R2 en R2 , tal que f(1, 1) = (0, 1) f(-1, 1

  12. EPR = ER and Scattering Amplitude as Entanglement Entropy Change

    E-Print Network [OSTI]

    Shigenori Seki; Sang-Jin Sin

    2014-04-03T23:59:59.000Z

    We study the causal structure of the minimal surface of the four-gluon scattering, and find a world-sheet wormhole parametrized by Mandelstam variables, thereby demonstrate the EPR = ER relation for gluon scattering. We also propose that scattering amplitude is the change of the entanglement entropy by generalizing the holographic entanglement entropy of Ryu-Takayanagi to the case where two regions are divided in space-time.

  13. Final Report DE-FG02-07ER64416

    SciTech Connect (OSTI)

    Seymour, Joseph D.

    2014-02-01T23:59:59.000Z

    The document provides the Final Report for DE-FG02-07ER64416 on the use of magnetic resonance (MR) methods to quantify transport in porous media impacted by biological and chemical processes. Products resulting from the research in the form of peer reviewed publications and conference presentations are presented. The research correlated numerical simulations and MR measurements to test simulation methodology. Biofilm and uranium detection by MR was demonstrated.

  14. Tunable, diode side-pumped Er:YAG laser

    DOE Patents [OSTI]

    Hamilton, C.E.; Furu, L.H.

    1997-04-22T23:59:59.000Z

    A discrete-element Er:YAG laser, side pumped by a 220 Watt peak-power InGaAs diode array, generates >500 mWatts at 2.94 {micro}m, and is tunable over a 6 nm range near about 2.936 {micro}m. The oscillator is a plano-concave resonator consisting of a concave high reflector, a flat output coupler, a Er:YAG crystal and a YAG intracavity etalon, which serves as the tuning element. The cavity length is variable from 3 cm to 4 cm. The oscillator uses total internal reflection in the Er:YAG crystal to allow efficient coupling of the diode emission into the resonating modes of the oscillator. With the tuning element removed, the oscillator produces up to 1.3 Watts of average power at 2.94 {micro}m. The duty factor of the laser is 6.5% and the repetition rate is variable up to 1 kHz. This laser is useful for tuning to an atmospheric transmission window at 2.935 {micro}m (air wavelength). The laser is also useful as a spectroscopic tool because it can access several infrared water vapor transitions, as well as transitions in organic compounds. Other uses include medical applications (e.g., for tissue ablation and uses with fiber optic laser scalpels) and as part of industrial effluent monitoring systems. 4 figs.

  15. Tunable, diode side-pumped Er: YAG laser

    DOE Patents [OSTI]

    Hamilton, Charles E. (Bellevue, WA); Furu, Laurence H. (Modesto, CA)

    1997-01-01T23:59:59.000Z

    A discrete-element Er:YAG laser, side pumped by a 220 Watt peak-power InGaAs diode array, generates >500 mWatts at 2.94 .mu.m, and is tunable over a 6 nm range near about 2.936 .mu.m. The oscillator is a plano-concave resonator consisting of a concave high reflector, a flat output coupler, a Er:YAG crystal and a YAG intracavity etalon, which serves as the tuning element. The cavity length is variable from 3 cm to 4 cm. The oscillator uses total internal reflection in the Er:YAG crystal to allow efficient coupling of the diode emission into the resonating modes of the oscillator. With the tuning element removed, the oscillator produces up to 1.3 Watts of average power at 2.94 .mu.m. The duty factor of the laser is 6.5% and the repetition rate is variable up to 1 kHz. This laser is useful for tuning to an atmospheric transmission window at 2.935 .mu.m (air wavelength). The laser is also useful as a spectroscopic tool because it can access several infrared water vapor transitions, as well as transitions in organic compounds. Other uses include medical applications (e.g., for tissue ablation and uses with fiber optic laser scalpels) and as part of industrial effluent monitoring systems.

  16. Completion Report for Well Cluster ER-6-1

    SciTech Connect (OSTI)

    Bechtel Nevada

    2004-10-01T23:59:59.000Z

    Well Cluster ER-6-1 was constructed for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Division at the Nevada Test Site, Nye County, Nevada. This work was initiated as part of the Groundwater Characterization Project, now known as the Underground Test Area Project. The well cluster is located in southeastern Yucca Flat. Detailed lithologic descriptions with stratigraphic assignments for Well Cluster ER-6-1 are included in this report. These are based on composite drill cuttings collected every 3 meters and conventional core samples taken below 639 meters, supplemented by geophysical log data. Detailed petrographic, chemical, and mineralogical studies of rock samples were conducted on 11 samples to resolve complex interrelationships between several of the Tertiary tuff units. Additionally, paleontological analyses by the U.S. Geological Survey confirmed the stratigraphic assignments below 539 meters within the Paleozoic sedimentary section. All three wells in the Well ER-6-1 cluster were drilled within the Quaternary and Tertiary alluvium section, the Tertiary volcanic section, and into the Paleozoic sedimentary section.

  17. Completion report for well ER-3-2

    SciTech Connect (OSTI)

    NONE

    1995-12-01T23:59:59.000Z

    Well ER-3-2 was drilled for the U.S. Department of Energy, Nevada Operations Office (DOE/NV), in support of the Nevada Environmental Restoration Project (NV ERP) at the Nevada Test Site. IT Corporation (IT) was the principal environmental contractor for the project. The roles and responsibilities of IT and other contractors involved in the project are described in the Raytheon Services Nevada (RSN) Drilling Program and the Underground Test Area Operable Unit Project Management Plan. The well will become part of the Underground Test Area (UGTA) monitoring well network.

  18. Lifetimes of negative parity states in {sup 168}Er

    SciTech Connect (OSTI)

    Genilloud, L. [Institut de Physique, Universite de Fribourg, Perolles, CH-1700 Fribourg, (Switzerland)] [Institut de Physique, Universite de Fribourg, Perolles, CH-1700 Fribourg, (Switzerland); Jolie, J. [Institut de Physique, Universite de Fribourg, Perolles, CH-1700 Fribourg, (Switzerland)] [Institut de Physique, Universite de Fribourg, Perolles, CH-1700 Fribourg, (Switzerland); Boerner, H. G. [Institut Laue-Langevin, F-38042 Grenoble Cedex 9, (France)] [Institut Laue-Langevin, F-38042 Grenoble Cedex 9, (France); Lehmann, H. [Institut Laue-Langevin, F-38042 Grenoble Cedex 9, (France)] [Institut Laue-Langevin, F-38042 Grenoble Cedex 9, (France); Becvar, F. [Faculty of Mathematics and Physics, Charles University, CZ-180 00 Prague 8, (Czech Republic)] [Faculty of Mathematics and Physics, Charles University, CZ-180 00 Prague 8, (Czech Republic); Krticka, M. [Faculty of Mathematics and Physics, Charles University, CZ-180 00 Prague 8, (Czech Republic)] [Faculty of Mathematics and Physics, Charles University, CZ-180 00 Prague 8, (Czech Republic); Zamfir, N. V. [WNSL, Yale University, New Haven, Connecticut 06520 (United States) [WNSL, Yale University, New Haven, Connecticut 06520 (United States); Clark University, Worcester, Massachusetts 01610 (United States); Casten, R. F. [WNSL, Yale University, New Haven, Connecticut 06520 (United States)] [WNSL, Yale University, New Haven, Connecticut 06520 (United States)

    2000-09-01T23:59:59.000Z

    Using the GRID method the lifetimes of 12 states belonging to four negative parity bands in {sup 168}Er were measured at the high flux reactor of the Institut Laue-Langevin (ILL). For K{sup {pi}}=0{sub 1}{sup -} and K{sup {pi}}=2{sub 1}{sup -} bands the absolute E1 transitions are in agreement with those obtained within the framework of the sdf IBA-1 model and their octupole vibrational character is confirmed. (c) 2000 The American Physical Society.

  19. Photoluminescence and positron annihilation spectroscopy investigation of (Ge, Er) codoped Si oxides deposited by magnetron sputtering

    SciTech Connect (OSTI)

    Heng, C. L.; Chelomentsev, E.; Peng, Z. L.; Mascher, P. [Department of Engineering Physics and Centre for Emerging Device Technologies, McMaster University, Hamilton, Ontario L8S 4K1 (Canada); Simpson, P. J. [Department of Physics and Astronomy, University of Western Ontario, London, Ontario N6A 3K7 (Canada)

    2009-01-01T23:59:59.000Z

    We have investigated the nature of violet-blue emission from (Ge, Er) codoped Si oxides (Ge+Er+SiO{sub 2}) using photoluminescence (PL) and positron annihilation spectroscopy (PAS) measurements. The PL spectra and PAS analysis for a control Ge-doped SiO{sub 2} (Ge+SiO{sub 2}) indicate that Ge-associated neutral oxygen vacancies (Ge-NOV) are likely responsible for the major emission in the violet-blue band. For Ge+Er+SiO{sub 2}, both Ge-NOV and GeO color centers are believed to be responsible for the emission band. The addition of Er has a significant influence on the emission, which is discussed in terms of Er-concentration-related structural change in the Ge+Er+SiO{sub 2}.

  20. Er/Si (111) interface intermixing investigation using core level photoemission

    SciTech Connect (OSTI)

    Haderbache, L.; Wetzel, P.; Pirri, C.; Peruchetti, J.C.; Bolmont, D.; Gewinner, G. (Laboratoire de Physique et de Spectroscopie Electronique, Faculte des Sciences et Techniques 4, rue des Freres Lumiere, 68093-Mulhouse Cedex (France))

    1990-07-23T23:59:59.000Z

    We present in this letter Si 2{ital p} core level photoemission measurements on the Er/Si (111) interface formed at room temperature. These spectroscopic data are compared with those measured on amorphous silicide films for various Er concentrations grown by coevaporation of Er and Si species at room temperature under ultrahigh vacuum conditions. This study reveals a strong interaction between Er and the Si (111) substrate even at very low coverage. A mixed interface is observed with silicide formation up to 6 monolayers of deposited metal which corresponds to the onset of erbium metal overgrowth. The Er concentration in the interfacial silicide is found to increase as a function of the deposited Er thickness. A model for the interface is proposed and discussed.

  1. Specific features of the nonradiative relaxation of Er{sup 3+} ions in epitaxial Si structures

    SciTech Connect (OSTI)

    Kudryavtsev, K. E., E-mail: konstantin@ipmras.ru; Kryzhkov, D. I.; Antonov, A. V.; Shengurov, D. V.; Shmagin, V. B.; Krasilnik, Z. F. [Russian Academy of Sciences, Institute for Physics of Microstructures (Russian Federation)

    2014-12-15T23:59:59.000Z

    The specific features of the nonradiative relaxation of Er{sup 3+} ions in Si:Er layers grown by sublimation molecular-beam epitaxy (SMBE) are studied. In Si:Er/Si diode structures containing precipitation-type emitting centers, a resonance photoresponse at the wavelength ? ? 1.5 ?m is observed, which is indicative of the nonradiative relaxation of Er3+ ions via the energy back-transfer mechanism. Saturation of the erbium-related photocurrent is for the first time observed at high temperatures. This allows estimation of the concentration of Er centers that undergo relaxation via the above-mentioned back-transfer mechanism (N{sub 0} ? 5 10{sup 16} cm{sup ?3}). In terms of order of magnitude, the estimated concentration N{sub 0} corresponds to the concentration of optically active Er ions upon excitation of the Si:Er layers by means of the recombination mechanism. The features of the nonradiative relaxation of Er{sup 3+} ions in Si:Er/Si structures with different types of emitting centers are analyzed.

  2. Completion Report for Well ER-2-1

    SciTech Connect (OSTI)

    Bechtel Nevada

    2004-10-01T23:59:59.000Z

    Well ER-2-1 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (formerly Nevada Operations Office), in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in February and March of 2003, as part of a hydrogeologic investigation program for the Yucca Flat/Climax Mine Corrective Action Unit in the northeastern portion of the Nevada Test Site. Well ER-2-1 was drilled as part of the Yucca Flat Corrective Action Unit Phase I drilling initiative. The well is located in north central Yucca Flat within Area 2 of the Nevada Test Site, and provided information regarding the radiological and physical environment near underground nuclear tests conducted in a saturated volcanic aquifer setting. Detailed lithologic descriptions with stratigraphic assignments are included in this report. These are based on composite drill cuttings collected every 3 meters and 83 sidewall samples taken at various depths between 113.7 and 754.4 meters, supplemented by geophysical log data. Detailed petrographic, chemical, and mineralogical studies of rock samples were conducted on 27 samples of drill cuttings. The well was collared in tuffaceous alluvium, and penetrated Tertiary-age tuffs of the Timber Mountain and Paintbrush Groups, Calico Hills and Wahmonie Formations, Crater Flat Group, Grouse Canyon Formation, before reaching total depth in the Tunnel Bed Formation.

  3. Properties of the rotational bands in {sup 161}Er

    SciTech Connect (OSTI)

    Chen, L.; Zhou, X. H.; Wang, S. T.; Zhang, N. T.; Zhou, H. B.; Li, G. S.; Wang, H. X.; Ding, B. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Graduate University of Chinese Academy of Sciences, Beijing 100049 (China); Zhang, Y. H.; Zheng, Y.; Liu, M. L.; Ma, F.; Fang, Y. D.; Hua, W.; Guo, S.; Qiang, Y. H.; Lei, X. G.; Guo, Y. X. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Zhu, L. H.; Wu, X. G. [China Institute of Atomic Energy, Beijing 102413 (China)

    2011-03-15T23:59:59.000Z

    High-spin states in {sup 161}Er have been studied experimentally using the {sup 150}Nd({sup 16}O,5n) reaction at a beam energy of 86 MeV. The 5/2{sup +}[642], 3/2{sup -}[521], and 11/2{sup -}[505] bands are extended up to high-spin states, and particularly the {alpha}=-1/2 branch of the ground state 3/2{sup -}[521] band is revised significantly. The relatively enhanced E1 transitions from the 3/2{sup -}[521] band to the 5/2{sup +}[642] band are observed. The band properties are analyzed within the framework of a triaxial particle-rotor model, and near-prolate shape and triaxial deformation are proposed to the 3/2{sup -}[521] and 5/2{sup +}[642] bands, respectively. Signature inversion occurs in the 3/2{sup -}[521] band after the band crossing in {sup 161}Er, and the systematics of the signature inversion associated with the 3/2{sup -}[521] configuration are discussed. By analyzing the properties of the relatively enhanced E1 transitions, it is found that the R(E1/E2) values show angular momentum dependence before the band crossing, and these enhanced E1 transitions could be attributed to octupole softness.

  4. Completion Report for Well ER-8-1

    SciTech Connect (OSTI)

    Bechtel Nevada

    2004-11-01T23:59:59.000Z

    Well ER-8-1 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in October and November of 2002 as part of a Hydrogeologic investigation program for the Yucca Flat/Climax Mine Corrective Action Unit in the northeastern portion of the Nevada Test Site. Well ER-8-1 is located at the north end of Yucca Flat approximately 580 meters south-southeast of the surface exposure of the Climax granitic intrusive. Detailed lithologic descriptions with stratigraphic assignments are included in this report. These are based on composite drill cuttings samples collected every 3 meters, and 21 sidewall samples taken at various depths between 351.1 and 573.0 meters, supplemented by incomplete geophysical log data. Detailed petrographic, geochemical, and mineralogical studies of rock samples were conducted on 22 samples of drill cuttings. Drilling began in tuffaceous alluvium, and the borehole penetrated Tertiary age bedded tuffs of the Volcanics of Oak Spring Butte and carbonate sediments of Paleozoic age, which were encountered at a depth of 334 meters. The borehole unexpectedly penetrated granite at the depth of 538.9 meters in which drilling was stopped. Contact metamorphic rocks and intrusive dikes associated with the Cretaceous-age granitic intrusive and at least one significant fault zone were encountered.

  5. LM Glasfiber er verdens strste pro-ducent af vinger til vindmller.

    E-Print Network [OSTI]

    LM Glasfiber er verdens største pro- ducent af vinger til vindmøller. Udvikling og afprøvning af mekaniske test", forklarer civilinge- niør Torben Jacobsen fra LM Glasfiber. LM Glasfiber i Lunderskov er internationale vindmølle-fabrikanter. Torben Jacobsen kom til LM Glasfiber fra Risø, hvor han var tilknyttet

  6. Electrical properties of Er-doped In0.53Ga0.47As

    E-Print Network [OSTI]

    Burke, Peter G.; Lu, Hong; Rudawski, Nicholas G.; Gossard, Arthur G.; Bahk, Je-Hyeong; Bowers, John E.

    2011-01-01T23:59:59.000Z

    03C117-3 Burke et al. : Electrical properties of Er-doped InElectrical properties of Er-doped In 0.53 Ga 0.47 As PeterBahk and John E. Bowers Electrical and Computer Engineering

  7. EPR = ER and Scattering Amplitude as Entanglement Entropy Change

    E-Print Network [OSTI]

    Seki, Shigenori

    2014-01-01T23:59:59.000Z

    Alday and Maldacena have found an exact minimal surface of open string world-sheet describing a gluon scattering. We study the causal structure of that minimal surface in AdS of position space, and find a world-sheet wormhole parametrized by Mandelstam variables. If we figure a gluon as an open string in AdS, the ribbon connecting the two strings always pass the world-sheet wormhole, demonstrating the EPR = ER for gluon scattering. Since entanglement is caused by an interaction, one can ask what is the relation between entanglement entropy and the scattering amplitude. We propose an answer by generalizing the holographic entanglement entropy (EE) of Ryu-Takayanagi to the case where two regions are divided in space-time and interpret the result as the change of EE.

  8. Controlling Rats and Mice

    E-Print Network [OSTI]

    Texas Wildlife Services

    2007-03-13T23:59:59.000Z

    at least 18 inches off the ground. 18? 18? TCE?Wildlife Services P.O. Box 100410 ? San Antonio, Texas 78201-1710 Rat-proofing Whenever it can be accomplished at a rea- sonable cost, rat-proofing is recommended as the most permanent means of control...

  9. Completion Report for Well ER-EC-1

    SciTech Connect (OSTI)

    Townsend, M.J.

    2000-12-01T23:59:59.000Z

    Well ER-EC-1 was drilled for the U.S. Department of Energy, Nevada Operations Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the spring of 1999 as part of the U.S. Department of Energy's hydrogeologic investigation well program in the Western Pahute Mesa - Oasis Valley region just west of the Test Site. A 44.5-centimeter surface hole was drilled and cased off to the depth 675.1 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 1,524.0 meters. A preliminary composite, static, water level was measured at the depth of approximately 566.3 meters prior to installation of the completion string. One completion string with three isolated, slotted intervals was installed in the well. Detailed lithologic descriptions with preliminary stratigraphic assignments are included in the report. These are based on composite drill cuttings collected every 3 meters and 31 sidewall samples taken at various depths below 680 meters, supplemented by geophysical log data. Detailed chemical and mineralogical studies of rock samples are in progress. The well penetrated Tertiary-age lava and tuff of the Timber Mountain Group, the Paintbrush Group, the Calico Hills Formation, the Crater Flat Group, and the Volcanics of Quartz Mountain. The preliminary geologic interpretation of data from Well ER-EC-1 indicates the presence of a structural trough or bench filled with a thick section of post-Rainier Mesa lava. These data also suggest that this site is located on a buried structural ridge that may separate the Silent Canyon and Timber Mountain caldera complexes.

  10. Completion Report for Well ER-18-2

    SciTech Connect (OSTI)

    Bechtel Nevada

    2003-09-01T23:59:59.000Z

    Well ER-18-2 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well, located on Buckboard Mesa in the western part of the Nevada Test Site, was drilled in the spring of 1999 as part of the U.S. Department of Energy's hydrogeologic investigation well program in the Western Pahute Mesa - Oasis Valley region just west of the Test Site. A 44.5-centimeter surface hole was drilled and cased off to the depth 408.1 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 762.0 meters. A preliminary composite, static, water level was measured at the depth of approximately 369.7 meters approximately two months after the completion string was installed. One completion string with three isolated, slotted intervals was installed in the well. Detailed lithologic descriptions with preliminary stratigraphic assignments are included in the report. These are based on composite drill cuttings collected every 3 meters and 15 sidewall samples taken at various depths below 420 meters, supplemented by geophysical log data and results of detailed chemical and mineralogical studies of rock samples. The upper part of the well penetrated Tertiary-age basalt, underlain by tuffaceous moat-filling sediments interbedded with ash-flow tuff units of the Thirsty Canyon Group and the Beatty Wash Formation. The lower half of the drill hole penetrated ash-flow tuff of the mafic-rich Ammonia Tanks Tuff. The geologic interpretation of data from Well ER-18-2 indicates that this site is located inside the structural margin of the Ammonia Tanks caldera.

  11. Carrier transfer from InAs quantum dots to ErAs metal nanoparticles

    SciTech Connect (OSTI)

    Haughn, C. R.; Chen, E. Y.; Zide, J. M. O.; Doty, M. F., E-mail: doty@udel.edu [Department of Materials Science and Engineering, University of Delaware, Newark, Delaware 19716 (United States); Steenbergen, E. H.; Bissell, L. J.; Eyink, K. G. [AFRL/RXAN, Wright Patterson AFB, Ohio 45433 (United States)

    2014-09-08T23:59:59.000Z

    Erbium arsenide (ErAs) is a semi-metallic material that self-assembles into nanoparticles when grown in GaAs via molecular beam epitaxy. We use steady-state and time-resolved photoluminescence to examine the mechanism of carrier transfer between indium arsenide (InAs) quantum dots and ErAs nanoparticles in a GaAs host. We probe the electronic structure of the ErAs metal nanoparticles (MNPs) and the optoelectronic properties of the nanocomposite and show that the carrier transfer rates are independent of pump intensity. This result suggests that the ErAs MNPs have a continuous density of states and effectively act as traps. The absence of a temperature dependence tells us that carrier transfer from the InAs quantum dots to ErAs MNPs is not phonon assisted. We show that the measured photoluminescence decay rates are consistent with a carrier tunneling model.

  12. Are entangled particles connected by wormholes? Support for the ER=EPR conjecture from entropy inequalities

    E-Print Network [OSTI]

    Gharibyan, Hrant

    2013-01-01T23:59:59.000Z

    If spacetime is built out of quantum bits, does the shape of space depend on how the bits are entangled? The ER=EPR conjecture relates the entanglement entropy of a collection of black holes to the cross sectional area of Einstein-Rosen (ER) bridges (or wormholes) connecting them. We show that the geometrical entropy of classical ER bridges satisfies the subadditivity, triangle, strong subadditivity, and CLW inequalities. These are nontrivial properties of entanglement entropy, so this is evidence for ER=EPR. We further show that the entanglement entropy associated to classical ER bridges has nonpositive interaction information. This is not a property of entanglement entropy, in general. For example, the entangled four qubit pure state |GHZ_4>=(|0000>+|1111>)/\\sqrt{2} has positive interaction information, so this state cannot be described by a classical ER bridge. Large black holes with massive amounts of entanglement between them can fail to have a classical ER bridge if they are built out of |GHZ_4> states....

  13. Completion Report for Well ER-7-1

    SciTech Connect (OSTI)

    Bechtel Nevada

    2004-11-01T23:59:59.000Z

    Well ER-7-1 was drilled for the U.S. Department of Energy's National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in January and February 2003, as part of a hydrogeologic investigation program in Yucca Flat. A 47.0-centimeter surface hole was drilled and cased off to a depth of 541.0 meters below the surface. The hole diameter was then decreased to 31.8 centimeters for drilling to a total depth of 762.0 meters. Detailed lithologic descriptions with stratigraphic assignments are included in this report. These are based on composite drill cuttings collected every 3 meters, and 62 sidewall samples taken at various depths below 85.3 meters, supplemented by geophysical log data. Detailed petrographic, chemical, and mineralogical studies were conducted on 22 samples of cuttings. The well was collared in Quaternary surficial deposits and penetrated a thick section of Tertiary-age volcanic deposits before terminating in carbonate rocks of Paleozoic-age.

  14. Completion Report for Wells ER-20-8 and ER-20-8#2 Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    SciTech Connect (OSTI)

    NSTec Environmental Management

    2011-02-28T23:59:59.000Z

    Wells ER-20-8 and ER-20-8#2 were drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada National Security Site (formerly Nevada Test Site), Nye County, Nevada. The holes were drilled in July and August 2009, as part of the Pahute Mesa Phase II drilling program. The primary purpose of these wells was to provide detailed hydrogeologic information in the Tertiary volcanic section that will help address uncertainties within the Pahute MesaOasis Valley hydrostratigraphic framework model. They may also be used as long-term monitoring wells.

  15. DEPART:tvIENT OF ENERG Y EERE PROJ ECT MANAGEMENT CEN T ER NEPA...

    Broader source: Energy.gov (indexed) [DOE]

    tvIENT OF ENERG Y EERE PROJ ECT MANAGEMENT CEN T ER NEPA DETERlIlINAIION RECIPIENT;County of Montgomery Page 1 of2 STATE: PA R liO i PROJELi TITLE: Montgomery County (PA):...

  16. Mitigating Bu er Over ows by Operating System Randomization 1 Monica Chew Dawn Song

    E-Print Network [OSTI]

    Song, Dawn

    of Bu#11;er Over ow A di#11;erent approach can be used to solve each of the three necessary conditions for successful exploits. These approaches were chosen with the goal of increasing the work factor for successful

  17. Electrical properties of Er-doped In0.53Ga0.47As

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    semiconductors doped with rare- earth elements is of signi?applications. 4 However, rare-earth elements, such as Er,pos- sibility of using rare-earth elements for doping narrow

  18. Are entangled particles connected by wormholes? Evidence for the ER = EPR conjecture from entropy inequalities

    E-Print Network [OSTI]

    Gharibyan, Hrant

    If spacetime is built out of quantum bits, does the shape of space depend on how the bits are entangled? The ER = EPR conjecture relates the entanglement entropy of a collection of black holes to the cross sectional area ...

  19. Magnetic Properties of RB66 (R = Gd, Tb, Ho, Er, and Lu)

    SciTech Connect (OSTI)

    Kim, Hyunsoo; Budko, Serguei; ATanatar, Makariy; Avdashchenko, D.V.; Matovnikov, A.V.; Mitroshenkov, N.V.; Novikov, V.V.; Prozorov, Ruslan

    2012-05-17T23:59:59.000Z

    We report magnetic susceptibility measurements of RB66 (R = Gd, Tb, Ho, Er, and Lu) boron-rich rare earth containing borides down to 50 mK. The data suggest a spin glass low temperature state for RB66 (R = Gd, Tb, Ho, and Er) with the freezing temperatures below 1 K. The magnetic properties appear to be influenced by the anisotropy of the magnetic moments, probably via the crystalline electric field effects.

  20. Ris har udgivet en rapport om moderne bioenergi. Den slr fast, at biomasse er en

    E-Print Network [OSTI]

    Risø har udgivet en rapport om moderne bioenergi. Den slår fast, at biomasse er en ligeså værdifuld eventyret med moderne bioenergi i hovedrollen. På Risø skubber vi eventyret i gang ved at udvikle nye større skala, end man troede det muligt for bare få år siden. Andre perspektiver for bioenergien er

  1. Rare earth focused ion beam implantation utilizing Er and Pr liquid alloy ion sources

    E-Print Network [OSTI]

    Steckl, Andrew J.

    Pr,10,11 Eu,12 Dy,13 Er,13­15 and Tm16 doped GaN. Rare earth elements were added during growthRare earth focused ion beam implantation utilizing Er and Pr liquid alloy ion sources L. C. Chao, B write implantation. © 1999 American Vacuum Society. S0734-211X 99 08306-7 I. INTRODUCTION Rare earth

  2. At skrive speciale eller ph.d.-afhandling p Ris er en mulighed

    E-Print Network [OSTI]

    forskningsmiljø- et. Det er en god ballast at have med i det senere karriereforløb". Når seniorforsker Jimmy Bak for Optik og Fluid Dynamik udbyder Jimmy Bak et forskningsprojekt som del af et ph.d.-studie. Projektet, der ugen. Side 11 >> E-mail: jimmy.bak@risoe.dk "Som vejleder vil jeg påstå, at udfor- dringen ikke kun er

  3. Influence of Bi on the Er luminescence in yttrium-erbium disilicate thin films

    SciTech Connect (OSTI)

    Scarangella, Adriana [MATIS-IMM CNR, Via S. Sofia 64, 95123 Catania (Italy); Dipartimento di Fisica e Astronomia, Universit di Catania, Via S. Sofia 64, 95123 Catania (Italy); Miritello, Maria, E-mail: maria.miritello@ct.infn.it [MATIS-IMM CNR, Via S. Sofia 64, 95123 Catania (Italy); Priolo, Francesco [MATIS-IMM CNR, Via S. Sofia 64, 95123 Catania (Italy); Dipartimento di Fisica e Astronomia, Universit di Catania, Via S. Sofia 64, 95123 Catania (Italy); Scuola Superiore di Catania, Universit di Catania, Via Valdisavoia 9, 95123 Catania (Italy)

    2014-09-28T23:59:59.000Z

    The influence of bismuth on erbium optical properties at 1.54??m has been investigated in yttrium-erbium disilicate thin films synthesized by magnetron co-sputtering and implanted with two Bi different doses. The Bi depth distribution and the evolution of its oxidation states after annealing treatments at 1000?C in two atmospheres, O{sub 2} and N{sub 2}, have been investigated. It was found that only in O{sub 2} the Bi{sup 3+} valence state is prevalent, thanks to the enhanced Bi mobility in the oxidizing ambient, as demonstrated by Rutherford backscattering spectrometry. At lower Bi content, although the formation of Bi{sup 0} metallic nanoparticles that are deleterious non radiative channels for Er luminescence, efficient energy transfer from Bi to Er has been obtained only in O{sub 2}. It is due to the excitation of ultraviolet broad Bi{sup 3+} absorption band and the energy transfer to Er ions. We have evaluated that in this case, Er effective excitation cross section increased by a factor of 5 in respect with the one for direct Er absorption at 488?nm. At higher Bi dose, this mechanism is absent, but an increased Er optical efficiency at 1.54??m has been observed under resonant excitation. It is due to the contribution of a fraction of Er ions having an increased lifetime. This phenomenon is associated with the formation of Bi agglomerates, induced at higher Bi doses, which well isolate Er from non-radiative quenching centers. The increased decay time assures higher optical efficiency at 1.54??m.

  4. Completion Report for Well ER-EC-2A

    SciTech Connect (OSTI)

    M. J. Townsend

    2002-03-01T23:59:59.000Z

    Well ER-EC-2A was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office, in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in January and February of 2000 as part of a hydrogeologic investigation program in the Pahute Mesa - Oasis Valley region just west of the Nevada Test Site. A 44.5-centimeter surface hole was drilled and cased off to a depth of 412.9 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 1,516.1 meters. One completion string with three isolated slotted intervals was installed in the well. A preliminary composite, static water level was measured at the depth of 228.0 meters, approximately two months after installation of the completion string. Detailed lithologic descriptions with preliminary stratigraphic assignments are included in this report. These are based on composite drill cuttings collected every 3 meters, and 81 sidewall samples taken at various depths below 212 meters, supplemented by geophysical log data. Detailed petrographic, chemical, and mineralogical studies of rock samples were conducted on 30 samples. The well was collared in rhyolite lava and penetrated Tertiary-age lava and tuff of the Volcanics of Fortymile Canyon and the Timber Mountain Group. The preliminary geologic interpretation of borehole data indicates that this well was drilled within the margins of the buried Rainier Mesa and Ammonia Tanks calderas, and that caldera collapse in this area was deeper than expected, resulting in a section of Volcanics of Fortymile Canyon (caldera-filling deposit) that is much thicker than expected.

  5. Completion Report for Well ER-EC-4

    SciTech Connect (OSTI)

    M. J. Townsend

    2000-09-01T23:59:59.000Z

    Well ER-EC-4 was drilled for the US Department of Energy, Nevada Operations Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the summer of 1999 as part of the U.S Department of Energy's hydrogeologic investigation well program in the Western Pahute Mesa - Oasis Valley region just west of the Test Site. A 44.5-centimeter surface hole was drilled and cased off to a depth of 263.7 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 1,062.8 meters. One completion string with three isolated slotted intervals was installed in the well. A preliminary composite, static, water level was measured at the depth of 228.3 meters, two months after installation of the completion string. Detailed lithologic descriptions with preliminary stratigraphic assignments are included in the report. These are based on composite drill cuttings collected every 3 meters, and 35 sidewall samples taken at various depths below 286.5 meters, supplemented by geophysical log data. Detailed chemical and mineralogical studies of rock samples are in progress. The well was collared in basalt and penetrated Tertiary-age lava and tuff of the Thirsty Canyon Group, the Volcanics of Fortymile Canyon, and the Timber Mountain Group. The preliminary geologic interpretation of data from this well helps pinpoint the location of the western margin of the Timber Mountain caldera complex in the southern Nevada volcanic field.

  6. Completion Report for Well ER-EC-5

    SciTech Connect (OSTI)

    Bechtel Nevada

    2004-10-01T23:59:59.000Z

    Well ER-EC-5 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the summer of 1999 as part of the U.S. Department of Energy's hydrogeologic investigation program in the Western Pahute Mesa - Oasis Valley region just west of the Nevada Test Site. A 44.5-centimeter surface hole was drilled and cased off to a depth of 342.6 meters below ground surface. The borehole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 762.0 meters. One completion string with three isolated slotted intervals was installed in the well. A preliminary composite, static water level was measured at the depth of 309.9 meters, 40 days after installation of the completion string. Detailed lithologic descriptions with stratigraphic assignments are included in the report. These are based on composite drill cuttings collected every 3 meters, and 18 sidewall samples taken at various depths below 349.6 meters, supplemented by geophysical log data and results from detailed chemical and mineralogical analyses of rock samples. The well penetrated Tertiary-age tuffs of the Thirsty Canyon Group, caldera moat-filling sedimentary deposits, lava of the Beatty Wash Formation, and landslide breccia and tuffs of the Timber Mountain Group. The well reached total depth in welded ashflow tuff of the Ammonia Tanks Tuff after penetrating 440.1 meters of this unit, which is also the main water-producing unit in the well. The geologic interpretation of data from this well constrains the western margin of the Ammonia Tanks caldera to the west of the well location.

  7. Completion report for Well ER-EC-6

    SciTech Connect (OSTI)

    M. J. Townsend

    2000-05-01T23:59:59.000Z

    Well ER-EC-6 was drilled for the U.S. Department of Energy, Nevada Operations Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the spring of 1999 as part of the DOE's hydrogeologic investigation well program in the Western Pahute Mesa - Oasis Valley region just west of the Nevada Test Site. A 66-centimeter surface hole was drilled and cased off to the depth of 485.1 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 1,524.0 meters. A preliminary composite, static, water level was measured at the depth of approximately 434.6 meters prior to installation of the completion string. One completion string with four isolated, slotted intervals was installed in the well. Detailed lithologic descriptions with preliminary stratigraphic assignments are included in the report. These are based on composite drill cuttings collected every 3 meters and 33 sidewall samples taken at various depths below 504.4 meters, supplemented by geophysical log data. Detailed chemical and mineralogical studies of rock samples are in progress. The well penetrated Tertiary-age lava and tuff of the Timber Mountain Group, the Paintbrush Group, the Calico Hills Formation, and the Volcanics of Quartz Mountain. Intense hydrothermal alteration was observed below the depth of 640 m. The preliminary geologic interpretation indicates that this site may be located on a buried structural ridge that separates the Silent Canyon and Timber Mountain caldera complexes.

  8. Completion Report for Well ER-EC-7

    SciTech Connect (OSTI)

    Bechtel Nevada

    2004-10-01T23:59:59.000Z

    Well ER-EC-7 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the summer of 1999 as part of the Department of Energy's hydrogeologic investigation program in the Western Pahute Mesa - Oasis Valley region just west of the Test Site. A 44.5-centimeter surface hole was drilled and cased off to a depth of 265.8 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 422.5 meters. The planned depth of 762 meters was not reached due to borehole stability problems. One completion string with two isolated slotted intervals was installed in the well. A preliminary composite, static, water level was measured at the depth of 227.8 meters, 20 days after installation of the completion string. Detailed lithologic descriptions with stratigraphic assignments are included in the report. These are based on composite drill cuttings, supplemented by geophysical log data, and incorporating data from detailed chemical and mineralogical studies of rock samples. Beneath a thin alluvial deposit, the well penetrated 410 meters of lava and bedded tuff of the Volcanics of Fortymile Canyon Group, deposited in the Timber Mountain caldera moat after caldera collapse. The geologic interpretation of data from this well provides information on the thickness, lithologic composition, and hydrogeologic character of moat-filling rocks in the southern portion of the Timber Mountain caldera complex in the southwestern Nevada volcanic field.

  9. Completion Report for Well ER-EC-8

    SciTech Connect (OSTI)

    Bechtel Nevada

    2004-10-01T23:59:59.000Z

    Well ER-EC-8 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the summer of 1999 as part of the U.S. Department of Energy's hydrogeologic investigation program in the Western Pahute Mesa - Oasis Valley region just west of the Nevada Test Site. A 44.5-centimeter surface hole was drilled and cased off to a depth of 129.8 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 609.6 meters. One completion string with three isolated slotted intervals was installed in the well. A preliminary composite, static water level was measured at the depth of 98.4 meters, 24 days after installation of the completion string. Detailed lithologic descriptions with stratigraphic assignments are included in the report. These are based on evaluation of composite drill cuttings collected every 3 meters, and 20 sidewall samples taken at various depths below 157.9 meters, supplemented by geophysical log data and results of detailed chemical and mineralogical studies of rock samples. Drilling began in Tertiary-age tuff of the Thirsty Canyon Group, and penetrated tuffs of the Beatty Wash Formation, tuff of Buttonhook Wash, and the upper portion of the Ammonia Tanks Tuff. The geologic interpretation of data from this well helps define the location of the western margin of the Timber Mountain caldera complex in the southwestern Nevada volcanic field. Geologic and hydrologic data from the well will aid in development of models to predict groundwater flow and contaminant migration within and near the Nevada Test Site.

  10. Completion Report for Well ER-12-2

    SciTech Connect (OSTI)

    Bechtel Nevada

    2004-11-01T23:59:59.000Z

    Well ER-12-2 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. The well was drilled from November 2002 to January 2003 as part of a hydrogeologic investigation program for the Yucca Flat Corrective Action Unit. The overall purpose of the well was to gather subsurface data to better characterize the hydrogeology in the northwestern portion of Yucca Flat. The well was drilled to total measured depth of 2,097.9 meters. The 131.1-centimeter-diameter borehole was left open (i.e., uncased) below the base of the intermediate casing at 901.6 meters. A piezometer string was installed outside the surface casing to a depth of 176.4 meters to monitor a zone of perched water. Data gathered during and shortly after hole construction include composite drill cuttings samples collected every 3 meters, sidewall core samples from 7 depths, various geophysical logs, and water level measurements. These data indicate that the well penetrated, in descending order, 137.5 meters of Quaternary and Tertiary alluvium, 48.8 meters of Tertiary volcanic rocks, 289.6 meters of Mississippian Chainman Shale, and 1,622.5 meters of Mississippian and Upper Devonian Eleana Formation consisting of shale, argillite, sandstone, quartzite, and limestone. Forty-seven days after the well was drilled the water level inside the main hole was tagged at the depth of 65.43 meters, and the water level inside the piezometer string was tagged at 127.14 meters.

  11. Pahute Mesa Well Development and Testing Analyses for Wells ER-20-8 and ER-20-4, Nevada National Security Site, Nye County, Nevada, Revision 0

    SciTech Connect (OSTI)

    Greg Ruskauff and Sam Marutzky

    2012-09-01T23:59:59.000Z

    Wells ER-20-4 and ER-20-8 were drilled during fiscal year (FY) 2009 and FY 2010 (NNSA/NSO, 2011a and b). The closest underground nuclear test detonations to the area of investigation are TYBO (U-20y), BELMONT (U-20as), MOLBO (U-20ag), BENHAM (U-20c), and HOYA (U-20 be) (Figure 1-1). The TYBO, MOLBO, and BENHAM detonations had working points located below the regional water table. The BELMONT and HOYA detonation working points were located just above the water table, and the cavity for these detonations are calculated to extend below the water table (Pawloski et al., 2002). The broad purpose of Wells ER-20-4 and ER-20-8 is to determine the extent of radionuclide-contaminated groundwater, the geologic formations, groundwater geochemistry as an indicator of age and origin, and the water-bearing properties and hydraulic conditions that influence radionuclide migration. Well development and testing is performed to determine the hydraulic properties at the well and between other wells, and to obtain groundwater samples at the well that are representative of the formation at the well. The area location, wells, underground nuclear detonations, and other features are shown in Figure 1-1. Hydrostratigraphic cross sections A-A, B-B, C-C, and D-D are shown in Figures 1-2 through 1-5, respectively.

  12. Electrospun nanofibers of Er{sup 3+}-doped TiO{sub 2} with photocatalytic activity beyond the absorption edge

    SciTech Connect (OSTI)

    Zheng, Yali; Wang, Wenzhong, E-mail: wzwang@mail.sic.ac.cn

    2014-02-15T23:59:59.000Z

    Er{sup 3+}-doped TiO{sub 2} nanofibers with different Er{sup 3+} contents were prepared via electrospinning and characterized by X-ray diffraction, scanning electron microscopy, ultravioletvisible diffuse reflectance spectroscopy and photocurrent measurement. Photocatalytic activities of the as-prepared samples were evaluated by the decolorization of methyl orange aqueous solution under simulated solar light irradiation. The results indicated that the photocatalytic activity of Er{sup 3+}-doped TiO{sub 2} nanofibers was much higher than that of the undoped one, and the optimal dosage of Er{sup 3+} at 1 mol% achieved the highest degradation rate. Moreover, the photocatalytic activity of Er{sup 3+}-doped TiO{sub 2} nanofibers under the irradiation of light with the wavelength beyond the absorption edge of TiO{sub 2} was explored by the decolorization of a dye, rhodamine B and the photodegradation of a typical colorless pollutant, phenol. The results further revealed the mechanism of the enhanced photocatalytic activity through Er{sup 3+} doping in TiO{sub 2} nanofibers. - Graphical abstract: Display Omitted - Highlights: ?Er{sup 3+}:TiO{sub 2} nanofibers with different Er{sup 3+} contents were prepared via electrospinning. ?The photocatalytic activity of Er{sup 3+}:TiO{sub 2} was much higher than that of undoped one. ?Er{sup 3+}:TiO{sub 2} could be activated by the light with wavelength beyond the absorption edge.

  13. Reservoir analysis model for battlefield operations

    E-Print Network [OSTI]

    Sullivan, Garrett James

    1988-01-01T23:59:59.000Z

    RESERVOIR ANALYSIS MODEL FOR BATTLEFIELD OPERATIONS A Thesis by GARRETT JAMES SULLIVAN Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE December 1988... Major Subject: Civil Engineering RESERVOIR ANALYSIS MODEL FOR BATTLEFIELD OPERATIONS A Thesis by GARRETT JAMES SULLIVAN Approved as to style and content by: Ralp A. Wurbs (Chair of Committee) mes (N er) neth tr ek Nem e Charles . a es...

  14. Carrier transport properties of nanocrystalline Er{sub 3}N@C{sub 80}

    SciTech Connect (OSTI)

    Sun, Yong, E-mail: sun@ele.kyutech.ac.jp; Maeda, Yuki; Sezaimaru, Hiroki; Sakaino, Masamichi [Department of Applied Science for Integrated System Engineering, Kyushu Institute of Technology, Senshuimachi, Tobata, Kitakyushu, Fukuoka 804-8550 (Japan); Kirimoto, Kenta [Department of Electrical and Electronic Engineering, Kitakyushu National College of Technology, 5-20-1 shii, Kokuraminami, Kitakyushu, Fukuoka 802-0985 (Japan)

    2014-07-21T23:59:59.000Z

    Electrical transport properties of the nanocrystalline Er{sub 3}N@C{sub 80} with fcc crystal structure were characterized by measuring both temperature-dependent d.c. conductance and a.c. impedance. The results showed that the Er{sub 3}N@C{sub 80} sample has characteristics of n-type semiconductor and an electron affinity larger than work function of gold metal. The Er{sub 3}N@C{sub 80}/Au interface has an ohmic contact behavior and the contact resistance was very small as compared with bulk resistance of the Er{sub 3}N@C{sub 80} sample. The charge carriers in the sample were thermally excited from various trapped levels and both acoustic phonon and ionic scatterings become a dominant process in different temperature regions, respectively. At temperatures below 250?K, the activation energy of the trapped carrier was estimated to be 35.5?meV, and the ionic scattering was a dominant mechanism. On the other hand, at temperatures above 350?K, the activation energy was reduced to 15.9?meV, and the acoustic phonon scattering was a dominant mechanism. In addition, a polarization effect from the charge carrier was observed at low frequencies below 2.0 MHz, and the relative intrinsic permittivity of the Er{sub 3}N@C{sub 80} nanocrystalline lattice was estimated to be 4.6 at frequency of 5.0 MHz.

  15. Super Rat Poison Man

    E-Print Network [OSTI]

    Hacker, Randi; Tsutsui, William

    2007-04-04T23:59:59.000Z

    Bob Square Tie. But Zheng Xiaoyu, the deposed head of China's State Food and Drug Administration begs to be excused. A rat poison manufacturer here in China applied for permission to name some of its products after him, partly because he's corrupt...

  16. Magnetic and superconducting phase diagrams in ErNi2B2C

    SciTech Connect (OSTI)

    Galvis, J.A.; Crespo, M.; Guillamon, I.; Suderow, Hermann; Vieira, S.; Garcia Hernandez, M.; Budko, Serguei; Canfield, Paul

    2012-03-30T23:59:59.000Z

    We present measurements of the superconducting upper critical field Hc2(T) and the magneticphasediagram of the superconductor ErNi2B2C made with a scanning tunneling microscope (STM). The magnetic field was applied in the basal plane of the tetragonal crystal structure. We have found large gapless regions in the superconductingphasediagram of ErNi2B2C, extending between different magnetic transitions. A close correlation between magnetic transitions and Hc2(T) is found, showing that superconductivity is strongly linked to magnetism.

  17. Audit Report: ER-L-02-01 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustionImprovement3--Logistical5/08 Attendance List fromER-L-02-01 Audit Report: ER-L-02-01 February

  18. Ice Classification in the Southern Ocean Using ERS-1 Scatterometer David S.Early, David G. Long

    E-Print Network [OSTI]

    Long, David G.

    Ice Classification in the Southern Ocean Using ERS-1 Scatterometer Data David S.Early, David G for classifying Southern Ocean sea ice from enhanced resolution ERS-1 scat- terometer images is presented of a measure of the anisotropy, is used to further help delineate sea ice types. Ice 'l'ype Backscatter feange

  19. Towards an Er-doped Si nanocrystal sensitized waveguide laser the thin line between gain and loss

    E-Print Network [OSTI]

    Polman, Albert

    somehow be eliminated from this scheme, the fabrication of low-cost Si based Er doped optical amplifiers1 Towards an Er-doped Si nanocrystal sensitized waveguide laser ­ the thin line between gain-doped Si nanocrystal co-doped SiO2, a composite material that can potentially be fabricated using a VLSI

  20. Extending ER Models to Capture Database Transformations to Build Data Sets for Data Mining

    E-Print Network [OSTI]

    Ordonez, Carlos

    transformation tables in abstract form can be useful not only for optimizing the generation of new data sets stages of data transformation, mathematical functions and the powerful SQL CASE statement, which doesExtending ER Models to Capture Database Transformations to Build Data Sets for Data Mining Carlos

  1. Environmental and Resource Studies Program Books, Maps & Videos Available For Use in ERS Courses

    E-Print Network [OSTI]

    Fox, Michael

    (organized by category, sorted by title) Books are located in ESC A204, and are available to be signed out) Otonabee Region Conservation Report Peterborough and the Kawarthas Practical Organic Chemistry PrinciplesEnvironmental and Resource Studies Program Books, Maps & Videos Available For Use in ERS Courses

  2. Excellent optical thermometry based on short-wavelength upconversion emissions in Er3

    E-Print Network [OSTI]

    Cao, Wenwu

    Excellent optical thermometry based on short-wavelength upconversion emissions in Er3 Yb3 codoped (Doc. ID 175753); published November 22, 2012 Excited by a 980 nm laser, upconversion emissions coupled levels, which can emit the shortest wavelength emissions for optical thermometry known so far

  3. Optical ampli ers in broadcast optical networks: A Yatindra Nath Singh, miete

    E-Print Network [OSTI]

    Singh Yatindra Nath

    Optical ampli ers in broadcast optical networks: A survey Yatindra Nath Singh, miete Department@ee.iitd.ernet.in Abstract Optical data networks are needed to meet ever increasing bandwidth re- quirements. Broadcast optical networks can provide easy and reliable imple- mentation of optical networks, but due to limited

  4. Propostes temes del treball sobre ER Treball sobre una font d'energia renovable

    E-Print Network [OSTI]

    Batiste, Oriol

    Propostes temes del treball sobre ER Treball sobre una font d'energia renovable Estudi de l'estat de desenvolupament, la implantaci´o i evoluci´o hist`orica d'u- na font d'energia renovable concreta: · Solar fotovoltaica · Solar trmica · Biocombustibiles · Elica Treball sobre una tecnologia espec

  5. Magnetism of Ho and Er Atoms on Close-Packed Metal Surfaces F. Donati,1

    E-Print Network [OSTI]

    Thévenaz, Jacques

    Magnetism of Ho and Er Atoms on Close-Packed Metal Surfaces F. Donati,1 A. Singha,1 S. Stepanow,2 C; published 3 December 2014) We investigated the magnetic properties of individual Ho atoms adsorbed on the (111) surface of Pt, which have been recently claimed to display single ion magnetic behavior

  6. ALGEBRA LINEAL I 1er Curso de CC. Fisicas. Examen Final. 4 de Febrero de 2005.

    E-Print Network [OSTI]

    Guijarro, Luis

    ALGEBRA LINEAL I 1er Curso de CC. Fisicas. Examen Final. 4 de Febrero de 2005. Apellidos: Nombre aplicacion lineal f : R3 R3 tal que Kerf = Nf x -y = 0 y -z = 0 Imf x + 2y + 3z = 0. 4. Sean L, U y B

  7. Evaluation of ERS Scatterometer soil moisture products over a half-degree region in Southwestern France

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    . Based on a high resolution soil moisture simulation (1km²) validated at the local scale, the ERS in the water and energy exchanges between the land surface and the atmosphere. Several authors have shown027231 #12;Aeronautics and Space Administration (NASA) sensors such as the AMSR-E radiometer (since 2002

  8. DEPARTIIIENT OF ENERGY EE RE PROJECT MANAG EM ENT CENT ER NEPA...

    Broader source: Energy.gov (indexed) [DOE]

    Irmo u.s. DEPARTIIIENT OF ENERGY EE RE PROJECT MANAG EM ENT CENT ER NEPA DETElThIINAIION PROJECT TITl.E: Irma Charing Cross Sidewalk Project ARRA-EECBG Page 1 of2 fJ Wl G) STATE:...

  9. NEWS FOR ECE ILLINOIS ALUMNI AND FRIENDS WINtER 20092010

    E-Print Network [OSTI]

    Liu, Gang "Logan"

    to study renewable energy 2 ECE news briefs 3 Andreas Cangellaris named head of ECE ILLINOIS 4 ArchitectNEWS FOR ECE ILLINOIS ALUMNI AND FRIENDS WINtER 2009­2010 Also in this issue: Goddard receives 2009­2010 To alumni and friends of ECE ILLINOIS, Speaking at a special session on scientific

  10. DEPARTMENT OF THE ARMY ER 11-1-XXX U.S. Army Corps of Engineers

    E-Print Network [OSTI]

    US Army Corps of Engineers

    #12;DEPARTMENT OF THE ARMY ER 11-1-XXX U.S. Army Corps of Engineers CECW-EV Washington, D.C. 20314 Military Sales (FMS), and any other Federal funded programs with a total project cost of $1 million or more

  11. 500 ZENITNovEmbEr2010 Warmte-eilandeffect van de stad Utrecht

    E-Print Network [OSTI]

    Brandsma, Theo

    500 ZENITNovEmbEr2010 Warmte-eilandeffect van de stad Utrecht Foto: Eclipse Ballooning, www waargenomen opwarming van de aarde. Het KNMI heeft daarom mobiele metingen ver- richt in de stad Utrecht. De indicatie van het effect van het warmte-eiland van de stad Utrecht op de temperatuur in De Bilt. W armte

  12. Een robotvogel die zo natuurge-trouw vliegt dat andere vogels er

    E-Print Network [OSTI]

    Twente, Universiteit

    bewegen. Die spieren kun je niet allemaal nabootsen in een kleine robot. Dus komt er flink wat analyse aan te pas om toch een robot te ontwerpen die levensecht vliegt. Die van Nijenhuis vliegt op een accu en.clearflightsolutions.com DOOR Christian Jongeneel fOtOgRafie Gijs van Ouwerkerk spin-Off RObOtvOGel "In de varianten valk en

  13. Gain Improvement of Er-doped Amplifiers for the Feedback Filters

    E-Print Network [OSTI]

    Song, Xiaomin

    2012-02-14T23:59:59.000Z

    contrast between these two materials and the electro-optical properties of Ti: LiNbO3. Furthermore, waveguide gain is introduced through selective surface erbium (Er) doping which yields high quality loss-compensated or even amplifying waveguides without...

  14. RisNyt NO1 2005 "Det globale brintsamfund er et langsigtet

    E-Print Network [OSTI]

    bæredygtigt brint- samfund. Arbejdet udføres under European Fuel Cell and Hydrogen Platform, som er på vej med." Sådan beskriver afdelings- chef Hans Larsen budskabet fra International Hydrogen Day i Berlin, hvor han gaffeltruck. Amtet har bevilget 3,75 millioner kr. i årene 2004-2006 til Hydrogen Innovation & Research Centre

  15. 76 PostErs EMBnet.journal 19.B An ontology describing congenital heart defects data

    E-Print Network [OSTI]

    76 PostErs EMBnet.journal 19.B An ontology describing congenital heart defects data Charalampos interests: the authors have declared that no competing interests exist. Abstract Congenital heart defects (CHDs) are a group of diseases characterized by a structural anomaly of the heart that is pre- sent

  16. Synthesis of multiferroic Er-Fe-O thin films by atomic layer and chemical vapor deposition

    SciTech Connect (OSTI)

    Mantovan, R., E-mail: roberto.mantovan@mdm.imm.cnr.it; Vangelista, S.; Wiemer, C.; Lamperti, A.; Tallarida, G. [Laboratorio MDM IMM-CNR, I-20864 Agrate Brianza (MB) (Italy); Chikoidze, E.; Dumont, Y. [GEMaC, Universit de Versailles St. Quentin en Yvelines-CNRS, Versailles (France); Fanciulli, M. [Laboratorio MDM IMM-CNR, I-20864 Agrate Brianza (MB) (Italy); Dipartimento di Scienza dei Materiali, Universit di Milano Bicocca, Milano (Italy)

    2014-05-07T23:59:59.000Z

    R-Fe-O (R?=?rare earth) compounds have recently attracted high interest as potential new multiferroic materials. Here, we report a method based on the solid-state reaction between Er{sub 2}O{sub 3} and Fe layers, respectively grown by atomic layer deposition and chemical vapor deposition, to synthesize Er-Fe-O thin films. The reaction is induced by thermal annealing and evolution of the formed phases is followed by in situ grazing incidence X-ray diffraction. Dominant ErFeO{sub 3} and ErFe{sub 2}O{sub 4} phases develop following subsequent thermal annealing processes at 850?C in air and N{sub 2}. Structural, chemical, and morphological characterization of the layers are conducted through X-ray diffraction and reflectivity, time-of-flight secondary ion-mass spectrometry, and atomic force microscopy. Magnetic properties are evaluated by magnetic force microscopy, conversion electron Mssbauer spectroscopy, and vibrating sample magnetometer, being consistent with the presence of the phases identified by X-ray diffraction. Our results constitute a first step toward the use of cost-effective chemical methods for the synthesis of this class of multiferroic thin films.

  17. Effect of Er doping on the structural and magnetic properties of cobalt-ferrite

    SciTech Connect (OSTI)

    Prathapani, Sateesh; Vinitha, M.; Das, D., E-mail: ddse@uohyd.ernet.in [School of Engineering Sciences and Technology, University of Hyderabad, Hyderabad 500046 (India); Jayaraman, T. V. [Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, Nebraska 68588 (United States)

    2014-05-07T23:59:59.000Z

    Nanocrystalline particulates of Er doped cobalt-ferrites CoFe{sub (2?x)}Er{sub x}O{sub 4} (0???x???0.04), were synthesized, using sol-gel assisted autocombustion method. Co-, Fe-, and Er- nitrates were the oxidizers, and malic acid served as a fuel and chelating agent. Calcination (400600?C for 4?h) of the precursor powders was followed by sintering (1000?C for 4?h) and structural and magnetic characterization. X-ray diffraction confirmed the formation of single phase of spinel for the compositions x?=?0, 0.01, and 0.02; and for higher compositions an additional orthoferrite phase formed along with the spinel phase. Lattice parameter of the doped cobalt-ferrites was higher than that of pure cobalt-ferrite. The observed red shift in the doped cobalt-ferrites indicates the presence of induced strain in the cobalt-ferrite matrix due to large size of the Er{sup +3} compared to Fe{sup +3}. Greater than two-fold increase in coercivity (?66?kA/m for x?=?0.02) was observed in doped cobalt-ferrites compared to CoFe{sub 2}O{sub 4} (?29?kA/m)

  18. Melting of small Arctic ice caps observed from ERS scatterometer time series

    E-Print Network [OSTI]

    Smith, Laurence C.

    Melting of small Arctic ice caps observed from ERS scatterometer time series Laurence C. Smith,1 of melt onset can be observed over small ice caps, as well as the major ice sheets and multi-year sea ice for 14 small Arctic ice caps from 19922000. Interannual and regional variability in the timing of melt

  19. CW-Pumped Evanescent Amplification Based on Side-Polished Fiber with Heavily Er3

    E-Print Network [OSTI]

    Shy,Jow-Tsong

    CW-Pumped Evanescent Amplification Based on Side-Polished Fiber with Heavily Er3þ -Doped Glass) A novel diffractive-pumping scheme is proposed to improve the evanescent amplification using blazed fiber grating for the first time. We also investigate the cw-pumped evanescent amplification at 1.55 mm

  20. Creating your Own Marketing Plan Part 1: CVs Res mes & Co erCVs, Resumes, & Cover

    E-Print Network [OSTI]

    Puglisi, Joseph

    Creating your Own Marketing Plan Part 1: CVs Res mes & Co erCVs, Resumes, & Cover Letters Tim for communicating fit Special Addition: what happens to your resume? Anything else?y g 2Affymetrix Confidential #12's perspective)p p ) 6Affymetrix Confidential #12;Creating Your Own Marketing Plan I:Plan I: CV's, Resumes

  1. ? "Y SILF: WE,ASIiER ? Mailed Mov. 15, 1934 A Science Service Feature

    E-Print Network [OSTI]

    of polr?er, t o the humidity and under extreme atmosi3heric conditions t?cy mount t o 30 per Cent. According t o the United States Bureau of Standards this idea sulting from the lubrication of the sprint be obtained under conditions of high humidity.a ( A l l rights reserved by Science Service, Inc,) u - - I

  2. 954ER4 Specification 4 ports RS-232 PCI-Express Serial cards

    E-Print Network [OSTI]

    Berns, Hans-Gerd

    954ER4 Specification 4 ports RS-232 PCI-Express Serial cards FEATURES 4 independent RS-232 serial ports with communication speeds up to 230 921 ­­­­Kbps Designed to meet PCI-Express Base Specification PC system. Majority of today's motherboard no longer come with serial ports or only have one port

  3. That which does not kill me makes me stronger: adapting to chronic ER stress

    E-Print Network [OSTI]

    Bedwell, David M.

    by activating signal transduction cascades that improve protein folding. One example of such a cascade is the unfolded protein response (UPR), which senses protein folding stress in the endoplasmic reticulum (ER) and leads to improvement in the protein folding and proces- sing capacity of the organelle. A central

  4. The electroluminescence mechanism of Er{sup 3+} in different silicon oxide and silicon nitride environments

    SciTech Connect (OSTI)

    Rebohle, L., E-mail: l.rebohle@hzdr.de; Wutzler, R.; Braun, M.; Helm, M.; Skorupa, W. [Institute of Ion Beam Physics and Materials Research, Helmholtz-Zentrum Dresden - Rossendorf, Bautzner Landstrae 400, 01328 Dresden (Germany); Berencn, Y.; Ramrez, J. M.; Garrido, B. [Dept. Electrnica, Mart i Franqus 1, Universitat de Barcelona, 08028 Barcelona (Spain); Hiller, D. [IMTEK, Faculty of Engineering, Albert-Ludwigs-University Freiburg, Georges-Khler-Allee 103, 79110 Freiburg (Germany)

    2014-09-28T23:59:59.000Z

    Rare earth doped metal-oxide-semiconductor (MOS) structures are of great interest for Si-based light emission. However, several physical limitations make it difficult to achieve the performance of light emitters based on compound semiconductors. To address this point, in this work the electroluminescence (EL) excitation and quenching mechanism of Er-implanted MOS structures with different designs of the dielectric stack are investigated. The devices usually consist of an injection layer made of SiO{sub 2} and an Er-implanted layer made of SiO{sub 2}, Si-rich SiO{sub 2}, silicon nitride, or Si-rich silicon nitride. All structures implanted with Er show intense EL around 1540?nm with EL power efficiencies in the order of 2??10{sup ?3} (for SiO{sub 2}:Er) or 2??10{sup ?4} (all other matrices) for lower current densities. The EL is excited by the impact of hot electrons with an excitation cross section in the range of 0.51.5??10{sup ?15?}cm{sup ?2}. Whereas the fraction of potentially excitable Er ions in SiO{sub 2} can reach values up to 50%, five times lower values were observed for other matrices. The decrease of the EL decay time for devices with Si-rich SiO{sub 2} or Si nitride compared to SiO{sub 2} as host matrix implies an increase of the number of defects adding additional non-radiative de-excitation paths for Er{sup 3+}. For all investigated devices, EL quenching cross sections in the 10{sup ?20} cm{sup 2} range and charge-to-breakdown values in the range of 110 C cm{sup ?2} were measured. For the present design with a SiO{sub 2} acceleration layer, thickness reduction and the use of different host matrices did not improve the EL power efficiency or the operation lifetime, but strongly lowered the operation voltage needed to achieve intense EL.

  5. Selective emission and luminescence of Er{sub 2}O{sub 3} under intense laser excitation

    SciTech Connect (OSTI)

    Marchenko, V M; Studenikin, M I [A M Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow (Russian Federation); Iskhakova, L D [Fiber Optics Research Center, Russian Academy of Sciences, Moscow (Russian Federation)

    2013-09-30T23:59:59.000Z

    The microstructure of Er{sub 2}O{sub 3} polycrystals synthesised by laser heating is studied. The synthesis of erbium silicate (Er{sub 2}SiO{sub 5}) layers was observed upon interaction of Er{sub 2}O{sub 3} and SiO{sub 2} melts. The dependences of the selective emission (SE) and luminescence spectra of Er{sub 2}O{sub 3} polycrystals in the range 200 1700 nm on the intensity of laser-thermal (at the wavelength ? = 10.6 ?m) and resonant laser (? ? 975 nm) excitation are investigated. The emission of heated Er{sub 2}O{sub 3} polycrystals arises as a result of multiphonon relaxation of absorbed energy and is a superposition of the SE at the electronic-vibrational transitions of Er{sup 3+} ions and the thermal radiation of the crystal lattice. The shape of the SE spectra of Er{sub 2}O{sub 3} polycrystals in the range 400 1700 nm almost does not change upon laser-thermal heating from 300 to 1500 K and subsequent cooling and corresponds to the absorption spectra of Er{sup 3+} ions. With increasing temperature, the thermal radiation intensity increases faster than the SE intensity, and the shape of the Er{sub 2}O{sub 3} spectrum becomes closer to the calculated spectrum of a blackbody. The anti-Stokes luminescence spectra of Er{sup 3+} ions formed under intense laser excitation of the {sup 4}I{sub 11/2} level are explained by additional SE caused by heating of the crystal matrix due to the Stokes losses. A difference between the SE and luminescence spectra is observed at low intensities of resonant laser excitation and low temperatures, when only the Stokes luminescence occurs. The temperature dependences of the SE and luminescence spectra of Er{sub 2}O{sub 3} upon laser excitation testify to the fundamental role played by the interaction of the electronic f-shell of Er{sup 3+} ions with crystal lattice vibrations in the processes of multiphonon radiative and nonradiative relaxation. The laser-thermal synthesis is promising for inprocess variation of the chemical composition of rare-earth samples. (interaction of laser radiation with matter)

  6. High multi-photon visible upconversion emissions of Er{sup 3+} singly doped BiOCl microcrystals: A photon avalanche of Er{sup 3+} induced by 980?nm excitation

    SciTech Connect (OSTI)

    Li, Yongjin; Song, Zhiguo, E-mail: songzg@kmust.edu.cn; Li, Chen; Wan, Ronghua; Qiu, Jianbei; Yang, Zhengwen; Yin, Zhaoyi; Yang, Yong; Zhou, Dacheng; Wang, Qi [School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093 (China)] [School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093 (China)

    2013-12-02T23:59:59.000Z

    Under 980?nm excitation, high multi-photon upconversion (UC) emission from the {sup 2}H{sub 11/2}/{sup 4}S{sub 3/2} (green) and {sup 4}F{sub 9/2} (red) levels of Er{sup 3+} ions were observed from Er{sup 3+} singly doped BiOCl microcrystals. These high-energy excited states were populated by a three to ten photon UC process conditionally, which depended on the pump power density and the Er{sup 3+} ion doping concentration, characterizing as a hetero-looping enhanced energy transfer avalanche UC process. UC emission lifetime and Raman analysis suggest that the unusual UC phenomena are initiated by the new and intense phonon vibration modes of BiOCl lattices due to Er{sup 3+} ions doping.

  7. Lasing characteristics of Er/sup 3 +/-doped silica fibers from 1553 up to 1603 nm

    SciTech Connect (OSTI)

    Kimura, Y.; Nakazawa, M.

    1988-07-15T23:59:59.000Z

    The laser oscillations from 1553 up to 1603 nm have been demonstrated in Er/sup 3 +/-doped silica fibers with a doping rate of 2500 ppm. Wide changes in laser oscillation wavelengths are due to broad splitting of the upper sublevels in the /sup 4/I/sub 152/ manifold, caused by the random structure of the silica matrix. It has been shown that unpumped parts of the Er/sup 3 +/ ions in the end pumped fiber laser configuration play an important role in the wavelength changes of the laser oscillation. For an absorbed pump power of 320 mW at 514 nm, output power of 0.5 mW was obtained at 1603 nm.

  8. The Theory of High Energy Collision Processes - Final Report DOE/ER/40158-1

    SciTech Connect (OSTI)

    Wu, Tai, T.

    2011-09-15T23:59:59.000Z

    In 1984, DOE awarded Harvard University a new Grant DE-FG02-84ER40158 to continue their support of Tai Tsun Wu as Principal Investigator of research on the theory of high energy collision processes. This Grant was renewed and remained active continuously from June 1, 1984 through November 30, 2007. Topics of interest during the 23-year duration of this Grant include: the theory and phenomenology of collision and production processes at ever higher energies; helicity methods of QED and QCD; neutrino oscillations and masses; Yang-Mills gauge theory; Beamstrahlung; Fermi pseudopotentials; magnetic monopoles and dyons; cosmology; classical confinement; mass relations; Bose-Einstein condensation; and large-momentum-transfer scattering processes. This Final Report describes the research carried out on Grant DE-FG02-84ER40158 for the period June 1, 1984 through November 30, 2007. Two books resulted from this project and a total of 125 publications.

  9. Photonic crystal light emitting diode based on Er and Si nanoclusters co-doped slot waveguide

    SciTech Connect (OSTI)

    Lo Savio, R.; Galli, M.; Liscidini, M.; Andreani, L. C. [Dipartimento di Fisica, Universit di Pavia, Via Bassi 6, 27100 Pavia (Italy); Franz, G.; Iacona, F.; Miritello, M. [MATIS-IMM CNR and Dipartimento di Fisica e Astronomia, Universit di Catania, via S. Sofia 64, 95123 Catania (Italy); Irrera, A. [CNR-IPCF, Viale Ferdinando Stagno d'Alcontres 37, 98158 Messina (Italy); Sanfilippo, D.; Piana, A. [ST Microelectronics, Stradale Primosole 50, 95121 Catania (Italy); Priolo, F. [MATIS-IMM CNR and Dipartimento di Fisica e Astronomia, Universit di Catania, via S. Sofia 64, 95123 Catania (Italy); Scuola Superiore di Catania, Universit di Catania, Via Valdisavoia 9, 95123 Catania (Italy)

    2014-03-24T23:59:59.000Z

    We report on the design, fabrication, and electro-optical characterization of a light emitting device operating at 1.54??m, whose active layer consists of silicon oxide containing Er-doped Si nanoclusters. A photonic crystal (PhC) is fabricated on the top-electrode to enhance the light extraction in the vertical direction, and thus the external efficiency of the device. This occurs if a photonic mode of the PhC slab is resonant with the Er emission energy, as confirmed by theoretical calculations and experimental analyses. We measure an increase of the extraction efficiency by a factor of 3 with a high directionality of light emission in a narrow vertical cone. External quantum efficiency and power efficiency are among the highest reported for this kind of material. These results are important for the realization of CMOS-compatible efficient light emitters at telecom wavelengths.

  10. IA --"-IScience Service Featuse 'I WHY T i E IJEAYIiER ?

    E-Print Network [OSTI]

    No. 591 April 3 IA --"-IScience Service Featuse 'I WHY T i E IJEAYIiER ? II city located oa the Ice.pp';g a% Bidialo, The ice c h i l l s a t h i n laye:. of a i r aver the Sake aridto laewwd. NOW$ vhen r may be srrfficionl t o produce a sheet cloud and g i ~ eBuffalo a day not oalg dwnt arid chilly Lu

  11. Amorphous Diamond Flat Panel Displays - Final Report of ER-LTR CRADA project with SI Diamond Technology

    E-Print Network [OSTI]

    Ager III, Joel W.

    1998-01-01T23:59:59.000Z

    Department of Energy under a CRADA (Cooperative Research andnm in size. Page 4 of 7 SIDT CRADA Final Report In order toFinal report of ER-LTR CRADA Project Lawrence Berkeley

  12. Activation of calcium-sensing receptor increases TRPC3 expression in rat cardiomyocytes

    SciTech Connect (OSTI)

    Feng, Shan-Li [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)] [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China); Sun, Ming-Rui [Department of Pharmacology, Qiqihaer Medical College, Qiqihaer 160001 (China)] [Department of Pharmacology, Qiqihaer Medical College, Qiqihaer 160001 (China); Li, Ting-Ting; Yin, Xin [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)] [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China); Xu, Chang-Qing [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China)] [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Sun, Yi-Hua, E-mail: syh200415@126.com [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)] [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)

    2011-03-11T23:59:59.000Z

    Research highlights: {yields} Calcium-sensing receptor (CaR) activation stimulates TRP channels. {yields} CaR promoted transient receptor potential C3 (TRPC3) expression. {yields} Adult rat ventricular myocytes display capacitative calcium entry (CCE), which was operated by TRPCs. {yields} TRPC channels activation induced by CaR activator sustained the increased [Ca{sup 2+}]{sub i} to evoke cardiomyocytes apoptosis. -- Abstract: Transient receptor potential (TRP) channels are expressed in cardiomyocytes, which gate a type of influx of extracellular calcium, the capacitative calcium entry. TRP channels play a role in mediating Ca{sup 2+} overload in the heart. Calcium-sensing receptors (CaR) are also expressed in rat cardiac tissue and promote the apoptosis of cardiomyocytes by Ca{sup 2+} overload. However, data about the link between CaR and TRP channels in rat heart are few. In this study, reverse transcriptase polymerase chain reaction (RT-PCR) and Western blotting were used to examine the expression of the TRP canonical proteins TRPC1 and TRPC3 in adult and neonatal rat cardiomyocytes. Laser scan confocal microscopy was used to detect intracellular [Ca{sup 2+}]{sub i} levels in isolated adult rat ventricular myocytes. The results showed that, in adult rat cardiomyocytes, the depletion of Ca{sup 2+} stores in the endoplasmic/sarcoplasmic reticulum (ER/SR) by thapsigargin induced a transient increase in [Ca{sup 2+}]{sub i} in the absence of [Ca{sup 2+}]{sub o} and the subsequent restoration of [Ca{sup 2+}]{sub o} sustained the increased [Ca{sup 2+}]{sub i} for a few minutes, whereas, the persisting elevation of [Ca{sup 2+}]{sub i} was reduced in the presence of the TRPC inhibitor SKF96365. The stimulation of CaR by its activator gadolinium chloride (GdCl{sub 3}) or spermine also resulted in the same effect and the duration of [Ca{sup 2+}]{sub i} increase was also shortened in the absence of [Ca{sup 2+}]{sub o}. In adult and neonatal rat cardiomyocytes, GdCl{sub 3} increased the expression of TRPC3 mRNA and protein, which were reversed by SKF96365 but not by inhibitors of the L-type channels and the Na{sup +}/Ca{sup 2+} exchangers. However, GdCl{sub 3} had no obvious effect on the expression of TRPC1 protein. These results suggested that CaR stimulation induced activation of TRP channels and promoted the expression of TRPC3, but not TRPC1, that sustained the increased [Ca{sup 2+}]{sub i}.

  13. Audit Report: ER-B-00-03 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energyon ArmedWaste andAccess to OUO AccessOpportunity |Report:892 Auditthe IdahoER-B-00-03

  14. Audit Report: ER-B-95-05 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energyon ArmedWaste andAccess to OUO AccessOpportunity |Report:892 AudittheER-B-95-05 Audit

  15. Audit Report: ER-B-95-06 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energyon ArmedWaste andAccess to OUO AccessOpportunity |Report:892 AudittheER-B-95-05

  16. Audit Report: ER-B-96-02 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energyon ArmedWaste andAccess to OUO AccessOpportunity |Report:892 AudittheER-B-95-052 Audit

  17. Audit Report: ER-B-97-03 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energyon ArmedWaste andAccess to OUO AccessOpportunity |Report:892 AudittheER-B-95-052

  18. Audit Report: ER-B-98-01 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energyon ArmedWaste andAccess to OUO AccessOpportunity |Report:892 AudittheER-B-95-0528-01

  19. Audit Report: ER-B-98-02 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energyon ArmedWaste andAccess to OUO AccessOpportunity |Report:892 AudittheER-B-95-0528-012

  20. Audit Report: ER-B-98-05 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energyon ArmedWaste andAccess to OUO AccessOpportunity |Report:892ER-B-98-05 Audit Report:

  1. Audit Report: ER-B-98-07 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energyon ArmedWaste andAccess to OUO AccessOpportunity |Report:892ER-B-98-05 Audit

  2. Audit Report: ER-B-98-08 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energyon ArmedWaste andAccess to OUO AccessOpportunity |Report:892ER-B-98-05 Audit8-08 Audit

  3. Audit Report: ER-B-98-09 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energyon ArmedWaste andAccess to OUO AccessOpportunity |Report:892ER-B-98-05 Audit8-08

  4. Y-12ers earn degrees through Friday Academy | Y-12 National Security

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLasDelivered energy consumption byAbout SRNL Home SRNLSecurityNationalComplex ers earn

  5. Absence of exchange interaction between localized magnetic moments and conduction-electrons in diluted Er{sup 3+} gold-nanoparticles

    SciTech Connect (OSTI)

    Lesseux, G. G., E-mail: lesseux@ifi.unicamp.br; Urbano, R. R. [Instituto de Fsica Gleb Wataghin, UNICAMP, 13083-859 Campinas, So Paulo (Brazil); Iwamoto, W. [Instituto de Fsica Gleb Wataghin, UNICAMP, 13083-859 Campinas, So Paulo (Brazil); Instituto de Fsica, UFU, 38400-902 Uberlndia, Minas Gerais (Brazil); Garca-Flores, A. F. [Centro de Cincias Naturais e Humanas, UFABC, 09210-971 Santo Andr, So Paulo (Brazil); Rettori, C. [Instituto de Fsica Gleb Wataghin, UNICAMP, 13083-859 Campinas, So Paulo (Brazil); Centro de Cincias Naturais e Humanas, UFABC, 09210-971 Santo Andr, So Paulo (Brazil)

    2014-05-07T23:59:59.000Z

    The Electron Spin Resonance (ESR) of diluted Er{sup 3+} magnetic ions in Au nanoparticles (NPs) is reported. The NPs were synthesized by reducing chloro triphenyl-phosphine gold(I) and erbium(III) trifluoroacetate. The Er{sup 3+} g-value along with the observed hyperfine splitting indicate that the Er{sup 3+} impurities are in a local cubic symmetry. Furthermore, the Er{sup 3+} ESR spectra show that the exchange interaction between the 4f and the conduction electrons (ce) is absent or negligible in Au{sub 1x}Er{sub x} NPs, in contrast to the ESR results in bulk Au{sub 1x}Er{sub x}. Therefore, the nature of this interaction needs to be reexamined at the nano scale range.

  6. Coupling of Er light emissions to plasmon modes on In{sub 2}O{sub 3}: Sn nanoparticle sheets in the near-infrared range

    SciTech Connect (OSTI)

    Matsui, Hiroaki, E-mail: hiroaki@ee.t.u-tokyo.ac.jp; Tabata, Hitoshi [Department of Bioengineering, The University of Tokyo, 1-3-7 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan); Department of Electrical Engineering and Information Systems, The University of Tokyo, 1-3-7 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan); Badalawa, Wasanthamala; Nomura, Wataru; Yatsui, Takashi; Ohtsu, Motoichi [Department of Electrical Engineering and Information Systems, The University of Tokyo, 1-3-7 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan); Hasebe, Takayuki [Central Customs Laboratory, Ministry of Finance, 5-3-6 Kashiwanoha, Kashiwa, Chiba 270-0882 (Japan); Furuta, Shinya [Tomoe Works Co. Ltd., 1-3-6 Namiyoke, Minato-ku, Osaka 552-0001 (Japan)

    2014-07-28T23:59:59.000Z

    Near-infrared Er photoluminescence (PL) is markedly modified using a plasmonic In{sub 2}O{sub 3}: Sn nanoparticle (NP) sheet. Modeling and optical measurements reveal the presence of different electric fields (E-field) in the NP sheet. The local E-field excited at the interface between the NP sheet and Er-emitting layer of ZnO contributes significantly towards the spectral modifications of Er PL due to matching with the photon energy of Er PL. We also determine the critical temperature for Er PL modifications, which is related to the energy transfer efficiency between Er transition dipoles in ZnO and the plasmon modes on the NP sheet.

  7. Er{sup 3+}/Yb{sup 3+}co-doped bismuth molybdate nanosheets upconversion photocatalyst with enhanced photocatalytic activity

    SciTech Connect (OSTI)

    Adhikari, Rajesh; Gyawali, Gobinda; Cho, Sung Hun [Research Center for Eco-Multifunctional Nanomaterials, Sun Moon University (Korea, Republic of); Narro-Garca, R. [Centro de Investigaciones en ptica, A. P.1-948, Len, Gto. 37150, Mxico (Mexico); Sekino, Tohru [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University (Japan); Lee, Soo Wohn, E-mail: swlee@sunmoon.ac.kr [Research Center for Eco-Multifunctional Nanomaterials, Sun Moon University (Korea, Republic of)

    2014-01-15T23:59:59.000Z

    In this paper, we report the microwave hydrothermal synthesis of Er{sup 3+}/Yb{sup 3+} co-doped Bi{sub 2}MoO{sub 6} upconversion photocatalyst. Crystal structure, morphology, elemental composition, optical properties and BET surface area were analyzed in detail. Infrared to visible upconversion luminescence at 532 nm and 546 nm of the co-doped samples was investigated under excitation at 980 nm. The results revealed that the co-doping of Er{sup 3+}/Yb{sup 3+} into Bi{sub 2}MoO{sub 6} exhibited enhanced photocatalytic activity for the decomposition of rhodamine B under simulated solar light irradiation. Enhanced photocatalytic activity can be attributed to the energy transfer between Er{sup 3+}/Yb{sup 3+} and Bi{sub 2}MoO{sub 6} via infrared to visible upconversion from Er{sup 3+}/Yb{sup 3+} ion and higher surface area of the Bi{sub 2}MoO{sub 6} nanosheets. Therefore, this synthetic approach may exhibit a better alternative to fabricate upconversion photocatalyst for integral solar light absorption. - Graphical abstract: Schematic illustration of the upconversion photocatalysis. Display Omitted - Highlights: Er{sup 3+}/Yb{sup 3+} co-doped Bi{sub 2}MoO{sub 6} upconversion photocatalyst is successfully synthesized. We obtained the nanosheets having high surface area. Upconversion of IR to visible light was confirmed. Upconversion phenomena can be utilized for effective photocatalysis.

  8. Atelier " i l ti ri e e l i e e ilie lli i el " e re er t ire e ri

    E-Print Network [OSTI]

    Passot, Thierry

    Atelier " i l ti ri e e l i e e ilie lli i el " e re er t ire e ri A r e i ti e A r e l i e ti l i e et le r l e e l er et re l i " le i ti e" i i t er e i i e r le l r e elle ti te relle t et r r el t li #12; Atelier " i l ti ri e e l i e e ilie lli i el " e re er t ire e ri

  9. The role of Nb in intensity increase of Er ion upconversion luminescence in zirconia

    SciTech Connect (OSTI)

    Smits, K., E-mail: smits@cfi.lu.lv; Sarakovskis, A.; Grigorjeva, L.; Millers, D. [Institute of Solid State Physics, University of Latvia, 8 Kengaraga Str., Riga LV1063 (Latvia); Grabis, J. [Institute of Inorganic Chemistry, Riga Technical University, Salaspils-1 LV2169 (Latvia)

    2014-06-07T23:59:59.000Z

    It is found that Nb co-doping increases the luminescence and upconversion luminescence intensity in rare earth doped zirconia. Er and Yb-doped nanocrystalline samples with or without Nb co-doping were prepared by sol-gel method and thermally annealed to check for the impact of phase transition on luminescence properties. Phase composition and grain sizes were examined by X-ray diffraction; the morphology was checked by scanning- and high-resolution transmission electron microscopes. Both steady-state and time-resolved luminescence were studied. Comparison of samples with different oxygen vacancy concentrations and different Nb concentrations confirmed the known assumption that oxygen vacancies are the main agents for tetragonal or cubic phase stabilization. The oxygen vacancies quench the upconversion luminescence; however, they also prevent agglomeration of rare-earth ions and/or displacement of rare-earth ions to grain surfaces. It is found that co-doping with Nb ions significantly (>20 times) increases upconversion luminescence intensity. Hence, ZrO{sub 2}:Er:Yb:Nb nanocrystals may show promise for upconversion applications.

  10. Atomistic simulation of Er irradiation induced defects in GaN nanowires

    SciTech Connect (OSTI)

    Ullah, M. W., E-mail: mohammad.ullah@helsinki.fi; Kuronen, A.; Djurabekova, F.; Nordlund, K. [Department of Physics, University of Helsinki, P.O. Box 64, FIN-00014 (Finland); Stukowski, A. [Technische Universitt Darmstadt, 64287 Darmstadt (Germany)

    2014-09-28T23:59:59.000Z

    Classical molecular dynamics simulation was used to irradiate a GaN nanowire with rear-earth erbium (Er). Ten cumulative irradiations were done using an ion energy of 37.5?keV on a 10??10?nm{sup 2} surface area which corresponds to a fluence of 1??10{sup 13?}cm{sup ?2}. We studied the location and types of defects produced in the irradiation. Er implantation leads to a net positive (expansion) strain in the nanowire and especially at the top region a clear expansion has been observed in the lateral and axial directions. The lattice expansion is due to the hydrostatic strain imposed by a large number of radiation induced defects at the top of the NW. Due to the large surface-to-volume ratio, most of the defects were concentrated at the surface region, which suggests that the experimentally observed yellow luminescence (YL) in ion implanted GaN NWs arises from surface defects. We observed big clusters of point defects and vacancy clusters which are correlated with stable lattice strain and the YL band, respectively.

  11. The {beta}-Decay Properties of Scissors Mode 1{sup +} States in {sup 164}Er

    SciTech Connect (OSTI)

    Yildirim, Z.; Kuliev, A.; Ozkan, S. [Sakarya University, Department of Physics, 54100, Sakarya (Turkey); Guliyev, E. [Institute of Physics, Academy of Sciences, H. Cavid Avenue 33, Baku (Azerbaijan); Institut fur Kernphysik, Technische Universitat Darmstadt, Darmstadt (Germany)

    2008-11-11T23:59:59.000Z

    The beta decay properties of collective I{sup {pi}}K = 1{sup +}1 states in doubly even deformed {sup 164}Er nuclei are investigated in the framework of the rotational invariant random-phase approximation. It is shown that an essential decrease of the rate of the allowed {beta}-decay to the excited 1{sup +}-states as compared with that to the ground state may be due to the orbital nature of the states. The model Hamiltonian includes restoring rotational invariance of the deformed single particle Hamiltonian forces and the spin-spin interactions. The analytical expressions for the Gamov-Teller (G-T) and Fermi (F) decay matrix elements are derived. The single-particle energies were obtained from the Warsaw deformed Woods-Saxon potential with deformation parameter {delta}{sub 2} = 0.24. The numerical results for {beta}{sup +} transition from {sup 164}Tm to {sup 164}Er indicate the importance of using rotational invariant Hamiltonian to explain experimental data.

  12. High-power, hybrid Er:fiber/Tm:fiber frequency comb source in the 2 {\\mu}m wavelength region

    E-Print Network [OSTI]

    Adler, Florian

    2012-01-01T23:59:59.000Z

    We present a 2-\\mum frequency comb based on a reliable mode-locked Er:fiber laser with 100 MHz repetition rate. After shifting the spectrum of the amplified Er:fiber comb to longer wavelengths, a single-clad Tm/Ho:fiber is used as a self-pumped pre-amplifier to generate a coherent and broadband spectrum centered at 1.93 \\mum. Subsequently, a cladding-pumped Tm:fiber amplifier boosts the system to a maximum output power of 4.8 W at 1.96 \\mum. After compression in a compact grating compressor, our amplified Er:fiber/Tm:fiber hybrid system delivers as much as 2.9 W with a pulse duration of 141 fs. The system's comb properties are examined via heterodyne measurement.

  13. In-situ observation of ErD2 formation during D2 loading via neutron diffraction.

    SciTech Connect (OSTI)

    Browning, James Frederick (Oak Ridge National Laboratory, Oak Ridge, TN); Llobet, Anna (Los Alamos National Laboratory, Los Alamos, NM); Snow, Clark Sheldon; Rodriguez, Mark Andrew; Wixom, Ryan R.

    2010-09-01T23:59:59.000Z

    In an effort to better understand the structural changes occurring during hydrogen loading of erbium target materials, we have performed in situ D{sub 2} loading of erbium metal (powder) at temperature (450 C) with simultaneous neutron diffraction analysis. This experiment tracked the conversion of Er metal to the {alpha} erbium deuteride (solid-solution) phase and then into the {beta} (fluorite) phase. Complete conversion to ErD{sub 2.0} was accomplished at 10 Torr D{sub 2} pressure with deuterium fully occupying the tetrahedral sites in the fluorite lattice.

  14. Specific features of self-compensation in Er{sub x}Sn{sub 1-x}Se solid solutions

    SciTech Connect (OSTI)

    Huseynov, J. I., E-mail: cih_58@mail.ru; Murguzov, M. I.; Ismayilov, Sh. S. [Azerbaijan State Pedagogical University (Azerbaijan)

    2013-03-15T23:59:59.000Z

    The effect of doping and degree of compensation on the conductivity activation energy {Delta}E{sub i} in Er{sub x}Sn{sub 1-x}Se has been investigated. The carrier concentration decreases at a low doping level in the case of low and moderate compensations. It is found that, beginning with x {>=} 0.005 at % Er, carriers in the solid solutions under study change sign, depending on the amount of substituted erbium in the SnSe samples that is in equilibrium with the selenium phase. This phenomenon can be explained in terms of the concepts of the self-compensation of donors in the Sn sublattice.

  15. Mechanisms of coactivation of estrogen receptor alpha (ER alpha)- and ER alpha/Sp-mediated gene transactivation by vitamin D receptor interacting protein 205 (DRIP205) in breast cancer cells

    E-Print Network [OSTI]

    Wu, Qian

    2009-05-15T23:59:59.000Z

    Vitamin D interacting protein 205 (DRIP205) is a mediator complex protein that anchors the complex to the estrogen receptor (ER) and other nuclear receptors (NRs). In ZR-75 breast cancer cells treated with 17?-estradiol (E2) and transfected with a...

  16. IFP --Oil & Gas Science and Technology --(Script : 1er specimen) --1 --Oil & Gas Science and Technology --rev. IFP, Vol. xx (2009), No X, pp. 00-00

    E-Print Network [OSTI]

    Boyer, Edmond

    IFP -- Oil & Gas Science and Technology -- (Script : 1er specimen) -- 1 -- Oil & Gas Science2010 Author manuscript, published in "Oil & Gas Science and Technology - Rev. IFP, 65, 3 (2010) 435-444" DOI : 10.2516/ogst/2010007 #12;IFP -- Oil & Gas Science and Technology -- (Script : 1er specimen) -- 2

  17. Scanning Hall Probe Imaging of ErNi2B2C

    SciTech Connect (OSTI)

    Bluhm, Hendrik; Sebastian, Suchitra; Guikema, Janice W.; Fisher, I.R.; Moler, Kathryn A.; /Stanford U., Appl. Phys. Dept.

    2005-12-02T23:59:59.000Z

    We report scanning Hall probe imaging of ErNi{sub 2}B{sub 2}C in the superconducting, antiferromagnetic, and weakly ferromagnetic regimes in magnetic fields up to 20 Oe, well below H{sub c1}, with two results. First, imaging isolated vortices shows that they spontaneously rearrange on cooling through the antiferromagnetic transition temperature T{sub N} = 6 K to pin on twin boundaries, forming a striped pattern. Second, a weak, random magnetic signal appears in the ferromagnetic phase below T{sub WFM} = 2.3 K, and no spontaneous vortex lattice is present down to 1.9 K. We conclude that ferromagnetism coexists with superconductivity either by forming small ferromagnetic domains or with oscillatory variation of the magnetization on sub-penetration depth length scales.

  18. Completion Report for Model Evaluation Well ER-11-2: Corrective Action Unit 98: Frenchman Flat

    SciTech Connect (OSTI)

    NSTec Underground Test Area and Boreholes Programs and Operations

    2013-01-22T23:59:59.000Z

    Model Evaluation Well ER-11-2 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of Nevada Environmental Management Operations at the Nevada National Security Site (formerly known as the Nevada Test Site). The well was drilled in August 2012 as part of a model evaluation program in the Frenchman Flat area of Nye County, Nevada. The primary purpose of the well was to provide detailed geologic, hydrogeologic, chemical, and radionuclide data that can be used to test and build confidence in the applicability of the Frenchman Flat Corrective Action Unit flow and transport models for their intended purpose. In particular, this well was designed to provide data to evaluate the uncertainty in model forecasts of contaminant migration from the upgradient underground nuclear test PIN STRIPE, conducted in borehole U-11b in 1966. Well ER-11-2 will provide information that can be used to refine the Phase II Frenchman Flat hydrostratigraphic framework model if necessary, as well as to support future groundwater flow and transport modeling. The main 31.1-centimeter (cm) hole was drilled to a total depth of 399.6 meters (m). A completion casing string was not set in Well ER-11-2. However, a piezometer string was installed in the 31.1-cm open hole. The piezometer is composed of 7.3-cm stainless-steel tubing hung on 6.0-cm carbon-steel tubing via a crossover sub. The piezometer string was landed at 394.5 m, for monitoring the lower tuff confining unit. Data collected during and shortly after hole construction include composite drill cuttings samples collected every 3.0 m, various geophysical logs, water quality (including tritium and other test-related radionuclides) measurements, and water level measurements. The well penetrated 42.7 m of Quaternary and Tertiary alluvium and 356.9 m of Tertiary volcanic rock. The water-level measured in the piezometer string on September 25, 2012, was 353.8 m below ground surface. No tritium above levels detectable by field methods were encountered in this hole. No well development or hydrologic testing was conducted in this well immediately after completion, and future well development, sampling, and hydrologic testing planned for this well will be limited due to the diameter of the piezometer string. The stratigraphy, general lithology, and the water level are as expected, but the section of geology encountered is higher than expected due to faulting. No tritium above the minimum detection limit of the field equipment was detected because the target aquifer (the Topopah Spring aquifer) at Well ER-11-2 is structurally higher than expected and thus unsaturated.

  19. Microwave multimode memory with an Er$^{3+}$:Y$_2$SiO$_5$ spin ensemble

    E-Print Network [OSTI]

    S. Probst; H. Rotzinger; A. V. Ustinov; P. A. Bushev

    2015-01-30T23:59:59.000Z

    Interfacing photonic and solid-state qubits within a hybrid quantum architecture offers a promising route towards large scale distributed quantum computing. In that respect, hybrid quantum systems combining circuit QED with ions doped into solids are an attractive platform. There, the ions serve as coherent memory elements and reversible conversion elements of microwave to optical qubits. Among many possible spin-doped solids, erbium ions offer the unique opportunity of a coherent conversion of microwave photons into the telecom C-band at $1.54\\,\\mu$m employed for long distance communication. In our work, we perform a time-resolved electron spin resonance study of an Er$^{3+}$:Y$_2$SiO$_5$ spin ensemble at milli-Kelvin temperatures and demonstrate multimode storage and retrieval of up to 16 coherent microwave pulses. The memory efficiency is measured to be 10$^{-4}$ at the coherence time of $T_2=5.6\\,\\mu$s.

  20. Genome sequence of the Brown Norway rat yields insights into

    E-Print Network [OSTI]

    Pachter, Lior

    Genome sequence of the Brown Norway rat yields insights into mammalian evolution Rat Genome Norway (BN) rat strain. The sequence represents a high-quality `draft' covering over 90% of the genome

  1. Postdoctoral fellowship in ore-deposit geology/igneous geochemistry Marie-Curie Initial Training Network ABYSS (ER1)

    E-Print Network [OSTI]

    Demouchy, Sylvie

    Postdoctoral fellowship in ore-deposit geology/igneous geochemistry Marie-Curie Initial Training Network ABYSS (ER1) Training network on reactive geological systems from the mantle to the abyssal sub-Cu-PGE deposits Requirements: Candidates must hold PhD in geology/geochemistry This fellowship is for a period

  2. ER 100/200, PP C184/284 GSI Section Notes Energy & Society Section Week 5: Thermodynamics

    E-Print Network [OSTI]

    Kammen, Daniel M.

    . Property Diagrams and Power Cycles V. Additional Material, Terms, and Variables VI. Practice Problems I form to another. As an equation, this is simply: Esystem = 0 = Ein ­ Eout #12;ER 100/200, PP C184 system its change in energy will be the balance between the heat transferred to (Qin) and the work done

  3. Project Transformation E.R. Bachmann & P.L. McDowell MV 4202 Page 1 of 14

    E-Print Network [OSTI]

    McDowell, Perry

    Project Transformation E.R. Bachmann & P.L. McDowell MV 4202 Page 1 of 14 7. Projection Transformations · Projection Transformations Projections transform three dimensional eye coordinates into points in three dimensional clip coordinates - Three dimensional object coordinates are projected onto

  4. Controls on Eurasian coastal sea ice formation, melt onset and decay from ERS scatterometry: regional contrasts and effects of river

    E-Print Network [OSTI]

    Smith, Laurence C.

    first-year sea ice (FYI) are observed in the Eurasian Arctic using the C-band (5.3 GHz) European RemoteControls on Eurasian coastal sea ice formation, melt onset and decay from ERS scatterometry and Kolyma rivers. Melt onset of the sea ice surface is associated with abrupt changes in s0 40, with values

  5. Final report for DOE-FG02-02ER54688: Study of nonlinear interactions between counterpropagating shear Alfven waves

    SciTech Connect (OSTI)

    Carter, T A

    2006-11-16T23:59:59.000Z

    Final report for DOE Plasma Physics Junior Faculty Development award DOE-FG02-02ER54688. Reports on research undertaken from 8/1/2002 until 5/15/2006, investigating nonlinear interactions between Alfven waves in a laboratory experiment.

  6. Effects of soil moisture and water depth on ERS SAR backscatter measurements from an Alaskan wetland complex

    E-Print Network [OSTI]

    Turetsky, Merritt

    2009 Accepted 17 April 2009 Keywords: Wetlands Boreal region Synthetic aperture radar Water level SoilEffects of soil moisture and water depth on ERS SAR backscatter measurements from an Alaskan was negatively correlated to water depth in all open (non-forested) wetlands when water table levels were more

  7. Faculty Profiles School of ElEctrical EnginEEring & computEr SciEncE

    E-Print Network [OSTI]

    Faculty Profiles School of ElEctrical EnginEEring & computEr SciEncE #12;circuits Patrick Chiang interconnects; robust, near-threshold computing); power-constrained, wireless medical electronics Notable: NSF circuits and components; embedded passives; interconnects and electronic packaging; signal integrity

  8. ER -AHR-ARNT Protein-Protein Interactions Mediate Estradiol-dependent Transrepression of Dioxin-inducible Gene Transcription*

    E-Print Network [OSTI]

    Perdew, Gary

    ER -AHR-ARNT Protein-Protein Interactions Mediate Estradiol- dependent Transrepression of Dioxin binding a wide variety of environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and halogenated aromatic hydrocarbons (HAHs) (5), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin, TCDD

  9. ISodotY of PetroIeumEr@nwrsI Petroleum Reservoir Simulation in a Virtual Environment

    E-Print Network [OSTI]

    a'4P w ._ m I I ISodotY of PetroIeumEr@nwrsI SPE 29118 Petroleum Reservoir Simulation in a VirtualSPE Member TM paperwas preperedfor presentationat the 13fh SPE Sym~ium on ReservoirSimulationheld in San, 1S2245SPEUT. ABSTRACT In this paper, we describe an approach to combining a reservoir simulation

  10. TOWARDS AN ER-DOPED SI NANOCRYSTAL SENSITIZED WAVEGUIDE LASER THE THIN LINE BETWEEN GAIN AND LOSS

    E-Print Network [OSTI]

    Kik, Pieter

    and waveguide. If the pump laser could somehow be eliminated from this scheme, the fabrication of low-cost SiTOWARDS AN ER-DOPED SI NANOCRYSTAL SENSITIZED WAVEGUIDE LASER ­ THE THIN LINE BETWEEN GAIN AND LOSS-doped SiO2, a composite material that can potentially be fabricated using a VLSI compatible process

  11. Investigation on upconversion photoluminescence of Bi3TiNbO9:Er3 Hengzhi Chen a

    E-Print Network [OSTI]

    Cao, Wenwu

    ) photons. There is a very high Yb-Er energy transfer efficiency [11]. The biggest hindrance of using UC for Condensed Matter Science and Technology, Department of Physics, Harbin Institute of Technology, Harbin role in device miniaturization. Doping high refractive index dielectric materials with rare-earth (RE

  12. Transformation E.R. Bachmann & P.L. McDowell MV 4202 Page 1 of3

    E-Print Network [OSTI]

    McDowell, Perry

    Transformation E.R. Bachmann & P.L. McDowell MV 4202 Page 1 of3 5. Transformations Overview window coordinates Modeling Transformations Projection Transformation Perspective Division Viewport Transformation Object Coordinates x, y, z, w Modelview Matrix Projection Matrix Eye Coordinates Clip Coordinates

  13. Dichlorodiphenyltrichloroethane technical mixture regulates cell cycle and apoptosis genes through the activation of CAR and ER? in mouse livers

    SciTech Connect (OSTI)

    Kazantseva, Yuliya A.; Yarushkin, Andrei A. [Institute of Molecular Biology and Biophysics SB RAMS, Novosibirsk, Timakova str., 2, 630117 (Russian Federation); Pustylnyak, Vladimir O., E-mail: pustylnyak@ngs.ru [Institute of Molecular Biology and Biophysics SB RAMS, Novosibirsk, Timakova str., 2, 630117 (Russian Federation); Novosibirsk State University, Novosibirsk, Pirogova str., 2, 630090 (Russian Federation)

    2013-09-01T23:59:59.000Z

    Dichlorodiphenyltrichloroethane (DDT) is a widely used organochlorine pesticide and a xenoestrogen that promotes rodent hepatomegaly and tumours. A recent study has shown significant correlation between DDT serum concentration and liver cancer incidence in humans, but the underlying mechanisms remain elusive. We hypothesised that a mixture of DDT isomers could exert effects on the liver through pathways instead of classical ERs. The acute effects of a DDT mixture containing the two major isomers p,p?-DDT (85%) and o,p?-DDT (15%) on CAR and ER? receptors and their cell cycle and apoptosis target genes were studied in mouse livers. ChIP results demonstrated increased CAR and ER? recruitment to their specific target gene binding sites in response to the DDT mixture. The results of real-time RT-PCR were consistent with the ChIP data and demonstrated that the DDT was able to activate both CAR and ER? in mouse livers, leading to target gene transcriptional increases including Cyp2b10, Gadd45?, cMyc, Mdm2, Ccnd1, cFos and E2f1. Western blot analysis demonstrated increases in cell cycle progression proteins cMyc, Cyclin D1, CDK4 and E2f1 and anti-apoptosis proteins Mdm2 and Gadd45?. In addition, DDT exposure led to Rb phosphorylation. Increases in cell cycle progression and anti-apoptosis proteins were accompanied by a decrease in p53 content and its transcriptional activity. However, the DDT was unable to stimulate the ?-catenin signalling pathway, which can play an important role in hepatocyte proliferation. Thus, our results indicate that DDT treatment may result in cell cycle progression and apoptosis inhibition through CAR- and ER?-mediated gene activation in mouse livers. These findings suggest that the proliferative and anti-apoptotic conditions induced by CAR and ER? activation may be important contributors to the early stages of hepatocarcinogenesis as produced by DDT in rodent livers. - Highlights: DDT activated both CAR and ER? and their cell cycle and apoptosis target genes. DDT produced increases in cell cycle and anti-apoptosis proteins and decrease in p53. DDT mixture was unable to stimulate the ?-catenin signalling pathway in mouse livers.

  14. Local structure around Er{sup 3+} in SiO{sub 2}-HfO{sub 2} glassy waveguides using EXAFS

    SciTech Connect (OSTI)

    Afify, N. D.; Dalba, G.; Armellini, C.; Ferrari, M.; Rocca, F.; Kuzmin, A. [Dipartimento di Fisica, Universita degli Studi di Trento, Via Sommarive 14, I-38100 Povo (Trento) (Italy); IFN-CNR, Istituto di Fotonica e Nanotecnologie del Consiglio Nazionale delle Ricerche, Sezione FBK-CeFSA di Trento, Via alla Cascata 56/C, I-38100 Povo (Trento) (Italy); Institute of Solid State Physics, University of Latvia, LV-1063 RIGA (Latvia)

    2007-07-01T23:59:59.000Z

    Er{sup 3+}-doped SiO{sub 2}-HfO{sub 2} glassy waveguides with HfO{sub 2} concentrations ranging from 10 to 50 mol % were prepared using the sol-gel route and deposited on v-SiO{sub 2} substrates using the dip-coating technique. The local environment around Er{sup 3+} ions was determined from Er L{sub 3}-edge extended x-ray-absorption fine-structure (EXAFS) measurements. The first coordination shell around Er{sup 3+} ions is composed of oxygen atoms. Hafnium is the main constituent of the second coordination shell of Er{sup 3+}, differing from the cases of pure SiO{sub 2} and SiO{sub 2}-TiO{sub 2} glassy hosts, in which silicon is the main atomic species. The local structure around Er{sup 3+} ions has been found to be independent on HfO{sub 2} concentration within the studied composition range. This fact implies that Er{sup 3+} ions are preferentially dispersed in HfO{sub 2}-rich regions of the glassy waveguide, even at the lowest HfO{sub 2} concentration. For all samples, no Er{sup 3+}-Er{sup 3+} coordination shell has been detected by EXAFS. The presented structural results allow us to understand some spectroscopic properties typical of Er{sup 3+}-doped SiO{sub 2} glassy waveguides co-doped with HfO{sub 2}.

  15. Water Retrieval by Norway Rats: Behavior as Deduction

    E-Print Network [OSTI]

    Wallace, R J

    1998-01-01T23:59:59.000Z

    1948). Burrows and feeding of the Norway a radial Mammalogy,Object retrieval preferences of Norway rats: An evolutionaryinedible objects by Norway rats: Motivational interactions

  16. albino rats rattus: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia Biology and...

  17. albino rat cfn: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia Biology and...

  18. albino wistar rats: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia Biology and...

  19. albino rats exposed: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia Biology and...

  20. albino rat anatomical: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia Biology and...

  1. The crystal structure of {pi}-ErBO{sub 3}: New single-crystal data for an old problem

    SciTech Connect (OSTI)

    Pitscheider, Almut [Institut fuer Allgemeine, Anorganische und Theoretische Chemie, Leopold-Franzens-Universitaet Innsbruck, Innrain 52a, A-6020 Innsbruck (Austria); Kaindl, Reinhard [Institut fuer Mineralogie und Petrographie, Leopold-Franzens-Universitaet Innsbruck, Innrain 52, A-6020 Innsbruck (Austria); Oeckler, Oliver [Department Chemie, Ludwig-Maximilians-Universitaet Muenchen, Butenandtstrasse 5-13, D-81377 Muenchen (Germany); Huppertz, Hubert, E-mail: Hubert.Huppertz@uibk.ac.a [Institut fuer Allgemeine, Anorganische und Theoretische Chemie, Leopold-Franzens-Universitaet Innsbruck, Innrain 52a, A-6020 Innsbruck (Austria)

    2011-01-15T23:59:59.000Z

    Single crystals of the orthoborate {pi}-ErBO{sub 3} were synthesized from Er{sub 2}O{sub 3} and B{sub 2}O{sub 3} under high-pressure/high-temperature conditions of 2 GPa and 800 {sup o}C in a Walker-type multianvil apparatus. The crystal structure was determined on the basis of single-crystal X-ray diffraction data, collected at room temperature. The title compound crystallizes in the monoclinic pseudowollastonite-type structure, space group C2/c, with the lattice parameters a=1128.4(2) pm, b=652.6(2) pm, c=954.0(2) pm, and {beta}=112.8(1){sup o} (R{sub 1}=0.0124 and wR{sub 2}=0.0404 for all data). -- graphical abstract: The first satisfying single-crystal structure determination of {pi}-ErBO{sub 3} sheds light on the extensively discussed structure of {pi}-orthoborates. The application of light pressure during the solid state synthesis yielded in high-quality crystals, due to pressure-induced crystallization. Research highlights: {yields} High-quality single crystals of {pi}-ErBO{sub 3} were prepared via high-pressure-induced crystallization. {yields} At least five different space groups for the rare-earth {pi}-orthoborates are reported. {yields} {pi}-ErBO{sub 3} is isotypic to the pseudowollastonite-type CaSiO{sub 3}. {yields} Remaining ambiguities regarding the structure of the rare-earth {pi}-orthoborates are resolved.

  2. Calcium-sensing receptor activation contributed to apoptosis stimulates TRPC6 channel in rat neonatal ventricular myocytes

    SciTech Connect (OSTI)

    Sun, Yi-hua [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)] [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China); Li, Yong-quan [Harbin Medical University, Harbin 150086 (China)] [Harbin Medical University, Harbin 150086 (China); Feng, Shan-li [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)] [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China); Li, Bao-xin; Pan, Zhen-wei [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China)] [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China); Xu, Chang-qing [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China)] [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Li, Ting-ting [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)] [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China); Yang, Bao-feng, E-mail: syh200415@yahoo.com.cn [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China)] [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China)

    2010-04-16T23:59:59.000Z

    Capacitative calcium entry (CCE) refers to the influx of calcium through plasma membrane channels activated on depletion of endoplasmic sarcoplasmic/reticulum (ER/SR) Ca{sup 2+} stores, which is performed mainly by the transient receptor potential (TRP) channels. TRP channels are expressed in cardiomyocytes. Calcium-sensing receptor (CaR) is also expressed in rat cardiac tissue and plays an important role in mediating cardiomyocyte apoptosis. However, there are no data regarding the link between CaR and TRP channels in rat heart. In this study, in rat neonatal myocytes, by Ca{sup 2+} imaging, we found that the depletion of ER/SR Ca{sup 2+} stores by thapsigargin (TG) elicited a transient rise in cytoplasmic Ca{sup 2+} ([Ca{sup 2+}]{sub i}), followed by sustained increase depending on extracellular Ca{sup 2+}. But, TRP channels inhibitor (SKF96365), not L-type channels or the Na{sup +}/Ca{sup 2+} exchanger inhibitors, inhibited [Ca{sup 2+}]{sub i} relatively high. Then, we found that the stimulation of CaR with its activator gadolinium chloride (GdCl{sub 3}) or by an increased extracellular Ca{sup 2+}([Ca{sup 2+}]{sub o}) increased the concentration of intracelluar Ca{sup 2+}, whereas, the sustained elevation of [Ca{sup 2+}]{sub i} was reduced in the presence of SKF96365. Similarly, the duration of [Ca{sup 2+}]{sub i} increase was also shortened in the absence of extracellular Ca{sup 2+}. Western blot analysis showed that GdCl{sub 3} increased the expression of TRPC6, which was reversed by SKF96365. Additionally, SKF96365 reduced cardiomyocyte apoptosis induced by GdCl{sub 3}. Our results suggested that CCE exhibited in rat neonatal myocytes and CaR activation induced Ca{sup 2+}-permeable cationic channels TRPCs to gate the CCE, for which TRPC6 was one of the most likely candidates. TRPC6 channel was functionally coupled with CaR to enhance the cardiomyocyte apoptosis.

  3. Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats

    SciTech Connect (OSTI)

    Banu, Sakhila K. [Reproductive Endocrinology and Cell Signaling Laboratory, Texas A and M University, TAMU 4458, College Station, Texas 77843 (United States); Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, TAMU 4458, College Station, Texas 77843 (United States); Interdisciplinary Faculties of Toxicology and Reproductive Biology, Texas A and M University, TAMU 4458, College Station, Texas 77843 (United States)], E-mail: skbanu@cvm.tamu.edu; Samuel, Jawahar B. [Department of Zoology, St. John's College, Palayamkottai, 627 002 (India); Arosh, Joe A. [Reproductive Endocrinology and Cell Signaling Laboratory, Texas A and M University, TAMU 4458, College Station, Texas 77843 (United States); Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, TAMU 4458, College Station, Texas 77843 (United States); Burghardt, Robert C. [Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, TAMU 4458, College Station, Texas 77843 (United States); Interdisciplinary Faculties of Toxicology and Reproductive Biology, Texas A and M University, TAMU 4458, College Station, Texas 77843 (United States); Aruldhas, Michael M. [Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600113 (India)], E-mail: aruldhasmm@yahoo.com

    2008-10-15T23:59:59.000Z

    Hexavalent chromium (Cr-VI) is used in a wide range of industries. Cr-VI from chromate industries and atmospheric emissions contribute to the Cr contamination in the environment. Cr is a reproductive metal toxicant that can traverse the placental barrier and cause a wide range of fetal effects including ovotoxicity. Therefore, the goal of this study was to investigate the basic mechanisms involved in Cr(VI)-induced ovotoxicity, and the protective role of vitamin C on ovarian follicular development and function in Cr(VI)-induced reproductive toxicity using both in vivo and in vitro approaches. Lactating rats received potassium dichromate (200 mg/L) with or without vitamin C (500 mg/L), through drinking water from postpartum days 1-21. During postnatal days (PND) 1-21 the pups received Cr(VI) via the mother's milk. Pups from both control and treatment groups were continued on regular diet and water from PND-21 onwards, and euthanized on PND-21, -45 and -65. Cr(VI) decreased steroidogenesis, GH and PRL, increased FSH and did not alter LH. Cr(VI) delayed puberty, decreased follicle number, and extended estrous cycle. Spontaneously immortalized rat granulosa cells were treated with 12.5 {mu}M (IC{sub 50}) potassium dichromate for 12 and 24 h, with or without vitamin C pre-treatment. Cr(VI) decreased the mRNA expressions of StAR, SF-1, 17{beta}-HSD-1, 17{beta}-HSD-2, FSHR, LHR, ER{alpha} and ER{beta}. Vitamin C pre-treatment protected ovary and granulosa cells from the deleterious effects of Cr(VI) toxicity, both in vivo and in vitro. Therefore, Cr(VI) toxicity could be a potential risk to the reproductive system in developing females, and vitamin C plays a protective role against Cr(VI)-induced ovotoxicity.

  4. Ethanol Consumption by Rat Dams During Gestation,

    E-Print Network [OSTI]

    Galef Jr., Bennett G.

    Ethanol Consumption by Rat Dams During Gestation, Lactation and Weaning Increases Ethanol examined effects of ethanol consumption in rat dams during gestation, lactation, and weaning on voluntary ethanol consumption by their adolescent young. We found that exposure to an ethanol-ingesting dam

  5. The Metabolism of Americium in the Rat

    E-Print Network [OSTI]

    Scott, K.G.

    2010-01-01T23:59:59.000Z

    t _ 'mE METABOLISM OF AMERICIUM IN THE RAT* By K. G. Scott,The distri :.1). tl.on of americium in the bone was studied,48A THE METABOLISM OF AMERICIUM IN THE RAT By K. G. Scott,

  6. Analysis of Well ER-6-2 Testing, Yucca Flat FY 2004 Testing Program, Nevada Test Site, Nye County, Nevada, Rev. No.: 0

    SciTech Connect (OSTI)

    Greg Ruskauff

    2005-07-01T23:59:59.000Z

    This report documents the analysis of data collected for Well ER-6-2 during fiscal year (FY) 2004 Yucca Flat well development and testing program (herein referred to as the ''testing program''). Participants in Well ER-6-2 field development and hydraulic testing activities were: Stoller-Navarro Joint Venture (SNJV), Bechtel Nevada (BN), Desert Research Institute (DRI), Los Alamos National Laboratory (LANL), Lawrence Livermore National Laboratory (LLNL), U.S. Geological Survey (USGS), and the University of Nevada, Las Vegas-Harry Reid Center (UNLV-HRC). The analyses of data collected from the Well ER-6-2 testing program were performed by the SNJV.

  7. Final Technical Report for Award DE-FG02-98ER41080

    SciTech Connect (OSTI)

    Chen, Alan

    2014-11-14T23:59:59.000Z

    The prime motivation of the project at McMaster University was to carry out the critical evaluation and compilation of Nuclear Structure and Decay data, and of nuclear astrophysics data with continued participation in the United States Nuclear Data Program (US-NDP). A large body of evaluated and compiled structure data were supplied for databases such as ENSDF, XUNDL, NSR, etc. residing on webpage of National Nuclear Data Center of the Brookhaven National Laboratory, Upton, New York, USA. Thermonuclear reaction rates of importance to stellar explosions, such as novae, x-ray bursts and supernovae, were evaluated as well. This effort was closely coupled to our ongoing experimental effort, which took advantage of radioactive ion beam and stable beam facilities worldwide to study these key reaction rates. This report contains brief descriptions of the various activities together with references to all the publications in peer-reviewed journals which were the result of work carried out with the award DE-FG02-98-ER41080, during 1998-2013.

  8. Helium release and microstructural changes in Er(D,T)2-x3Hex films).

    SciTech Connect (OSTI)

    Gelles, D. S. (Pacific Northwest National Laboratory, Richland, WA); Browning, James Frederick; Snow, Clark Sheldon; Banks, James Clifford; Mangan, Michael A.; Rodriguez, Mark Andrew; Brewer, Luke N.; Kotula, Paul Gabriel

    2007-12-01T23:59:59.000Z

    Er(D,T){sub 2-x} {sup 3}He{sub x}, erbium di-tritide, films of thicknesses 500 nm, 400 nm, 300 nm, 200 nm, and 100 nm were grown and analyzed by Transmission Electron Microscopy, X-Ray Diffraction, and Ion Beam Analysis to determine variations in film microstructure as a function of film thickness and age, due to the time-dependent build-up of {sup 3}He in the film from the radioactive decay of tritium. Several interesting features were observed: One, the amount of helium released as a function of film thickness is relatively constant. This suggests that the helium is being released only from the near surface region and that the helium is not diffusing to the surface from the bulk of the film. Two, lenticular helium bubbles are observed as a result of the radioactive decay of tritium into {sup 3}He. These bubbles grow along the [111] crystallographic direction. Three, a helium bubble free zone, or 'denuded zone' is observed near the surface. The size of this region is independent of film thickness. Four, an analysis of secondary diffraction spots in the Transmission Electron Microscopy study indicate that small erbium oxide precipitates, 5-10 nm in size, exist throughout the film. Further, all of the films had large erbium oxide inclusions, in many cases these inclusions span the depth of the film.

  9. THERMODYNAMIC AND KINETIC MODELING OF ADVANCED NUCLEAR FUELS - FINAL LDRD-ER REPORT

    SciTech Connect (OSTI)

    Turchi, P

    2011-11-28T23:59:59.000Z

    This project enhanced our theoretical capabilities geared towards establishing the basic science of a high-throughput protocol for the development of advanced nuclear fuel that should couple modern computational materials modeling and simulation tools, fabrication and characterization capabilities, and targeted high throughput performance testing experiments. The successful conclusion of this ER project allowed us to upgrade state-of-the-art modeling codes, and apply these modeling tools to ab initio energetics and thermodynamic assessments of phase diagrams of various mixtures of actinide alloys, propose a tool for optimizing composition of complex alloys for specific properties, predict diffusion behavior in diffusion couples made of actinide and transition metals, include one new equation in the LLNL phase-field AMPE code, and predict microstructure evolution during alloy coring. In FY11, despite limited funding, the team also initiated an experimental activity, with collaboration from Texas A&M University by preparing samples of nuclear fuels in bulk forms and for diffusion couple studies and metallic matrices, and performing preliminary characterization.

  10. Letter Report: Borehole Flow and Horizontal Hydraulic Conductivity with Depth at Well ER-12-4

    SciTech Connect (OSTI)

    Phil L. Oberlander; Charles E. Russell

    2005-12-31T23:59:59.000Z

    Borehole flow and fluid temperature during pumping were measured at well ER-12-4 at the Nevada Test Site in Nye County, Nevada. This well was constructed to characterize the carbonate aquifer. The well is cased from land surface to the total depth at 1,132 m (3,713 ft bgs) below ground surface (bgs). The screened section of the well consists of alternating sections of slotted well screen and blank casing from 948 to 1,132 m bgs (3,111 to 3,713 ft bgs). Borehole flow velocity (LT-1) with depth was measured with an impeller flowmeter from the top of the screened section to the maximum accessible depth while the well was pumped and under ambient conditions. A complicating factor to data interpretation is that the well was not filter packed and there is upward and downward vertical flow in the open annulus under ambient and pumping conditions. The open annulus in the well casing likely causes the calculated borehole flow rates being highly nonrepresentative of inflow from the formation. Hydraulic conductivities calculated under these conditions would require unsupportable assumptions and would be subject to very large uncertainties. Borehole hydraulic conductivities are not presented under these conditions.

  11. Analysis of ER-12-3 FY 2005 Hydrologic Testing, Nevada Test Site, Nye County, Nevada, Rev. No.: 0

    SciTech Connect (OSTI)

    Bill Fryer

    2006-07-01T23:59:59.000Z

    This report documents the analysis of data collected for ER-12-3 during the fiscal year (FY) 2005 Rainier Mesa/Shoshone Mountain well development and hydraulic testing program (herein referred to as the ''testing program''). Well ER-12-3 was constructed and tested as a part of the Corrective Action Unit (CAU) 99, Rainier Mesa/Shoshone Mountain, Phase I drilling program during FY 2005. These activities were conducted on behalf of the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO) for the Underground Test Area (UGTA) Project. As shown on Figure 1-1, ER-12-3 is located in central Rainier Mesa, in Area 12 of the Nevada Test Site (NTS). Figure 1-2 shows the well location in relation to the tunnels under Rainier Mesa. The well was drilled to a total depth (TD) of 4,908 feet (ft) below ground surface (bgs) (surface elevation 7,390.8 ft above mean sea level [amsl]) in the area of several tunnels mined into Rainier Mesa that were used historically for nuclear testing (NNSA/NSO, 2006). The closest nuclear test to the well location was YUBA (U-12b.10), conducted in the U-12b Tunnel approximately 1,529 ft northeast of the well site. The YUBA test working point elevation was located at approximately 6,642 ft amsl. The YUBA test had an announced yield of 3.1 kilotons (kt) (SNJV, 2006b). The purpose of this hydrogeologic investigation well is to evaluate the deep Tertiary volcanic section below the tunnel level, which is above the regional water table, and to provide information on the section of the lower carbonate aquifer-thrust plate (LCA3) located below the Tertiary volcanic section (SNJV, 2005b). Details on the drilling and completion program are presented in the ''Completion Report for Well ER-12-3 Corrective Action Unit 99: Rainier Mesa - Shoshone Mountain'' (NNSA/NSO, 2006). Development and hydraulic testing of ER-12-3 took place between June 3 and July 22, 2005. The development objectives included removing residual drilling fluids and improving the hydraulic connection of the well within the lower carbonate aquifer (LCA). The hydraulic testing objectives focused on obtaining further hydrogeologic, geochemical, and radiochemical data for the site. Details on the data collected during the testing program are presented in the report ''Rainier Mesa Well ER-12-3 Data Report for Well Development and Hydraulic Testing'' (SNJV, 2006b). Participants in ER-12-3 testing activities were: Stoller-Navarro Joint Venture (SNJV), Bechtel Nevada (BN), Desert Research Institute (DRI), Los Alamos National Laboratory (LANL), Lawrence Livermore National Laboratory (LLNL), and the U.S. Geological Survey (USGS). Stoller-Navarro Joint Venture served as the lead contractor responsible for providing site supervision, development and testing services, and waste management services; BN provided construction and engineering support services; DRI provided well logging services and participated in groundwater sampling and laboratory analyses; LANL and LLNL participated in groundwater sampling and laboratory analyses; and the USGS performed laboratory analyses. Analyses of data from the ER-12-3 testing program presented in this document were performed by SNJV except as noted.

  12. Completion Report for the Well ER-6-2 Site Corrective Action Unit 97: Yucca Flat - Climax Mine

    SciTech Connect (OSTI)

    NSTec Environmental Management

    2008-03-01T23:59:59.000Z

    Well ER-6-2 and its satellite hole, Well ER-6-2 No.1, were drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. Well ER-6-2 was drilled in two stages in 1993 and 1994; the satellite hole, Well ER-6-2 No.1 was drilled nearby in 1993 but was abandoned. The wells were drilled as part of a hydrogeologic investigation program for the Yucca Flat-Climax Mine Corrective Action Unit Number 97, in the northeastern portion of the Nevada Test Site. The wells are located in Yucca Flat, within Area 6 of the Nevada Test Site. The wells provided information regarding the radiological and hydrogeological environment in a potentially down-gradient position from tests conducted in northern and central Yucca Flat. Construction of Well ER-6-2 began with a 1.2-meter-diameter surface conductor hole, which was drilled and cased off to a depth of 30.8 meters below the surface. A 50.8-centimeter diameter surface hole was then rotary drilled to the depth of 578.5 meters and cased off to the depth of 530.4 meters. The hole diameter was then reduced to 27.0 centimeters, and the borehole was advanced to a temporary depth of 611.4 meters. The borehole was conventionally cored to a total depth of 1,045 meters with a diameter of 14.0 centimeters. Borehole sloughing required cementing and re-drilling of several zones. The open-hole completion accesses the lower carbonate aquifer, the CP thrust fault, and the upper clastic confining unit. A fluid level depth of 543.2 meters was most recently measured in the open borehole in September 2007. No radionuclides were encountered during drilling. The satellite hole Well ER-6-2 No.1 was drilled approximately 15.2 meters north of Well ER-6-2 on the same drill pad. This was planned to be used as an observation well during future hydrologic testing at Well ER-6-2; however, the satellite hole was abandoned at the depth of 399 meters due to stuck drill pipe, and was subsequently cemented to the surface. Detailed lithologic descriptions with stratigraphic assignments in this report are based on composite drill cuttings samples collected every 3 meters, cores taken between the depths of 619.3 and 1,042.4 meters, and geophysical log data. Stratigraphic assignments within the Paleozoic section are based on paleontological analyses. The well was collared in alluvium and at 30.8 meters penetrated Paleozoic carbonate rocks. These consisted of dolostone with minor shale and limestone of the Bonanza King Formation, and limestone with minor quartzite, sandstone, and dolostone assigned to the Guilmette Formation. The borehole reached total depth in a shale unit assigned to the Chainman Shale. The units below the Bonanza King Formation are overturned due to faulting and folding and, therefore, are stratigraphically upside-down.

  13. Q values for neutrinoless double-electron capture in {sup 96}Ru, {sup 162}Er, and {sup 168}Yb

    SciTech Connect (OSTI)

    Eliseev, S.; Blaum, K. [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, D-69117 Heidelberg (Germany); Nesterenko, D. [Department of Physics, St. Petersburg State University, RU-198504 St. Petersburg (Russian Federation); Block, M.; Herfurth, F.; Minaya Ramirez, E. [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Planckstrasse 1, D-64291 Darmstadt (Germany); Droese, C.; Schweikhard, L. [Institut fuer Physik, Ernst-Moritz-Arndt-Universitaet, D-17487 Greifswald (Germany); Novikov, Yu. N. [Petersburg Nuclear Physics Institute, Gatchina, RU-188300 St. Petersburg (Russian Federation); Zuber, K. [Institut fuer Kern- und Teilchenphysik, Technische Universitaet, D-01069 Dresden (Germany)

    2011-03-15T23:59:59.000Z

    The Q values of the neutrinoless double-electron capture transitions in {sup 96}Ru, {sup 162}Er, and {sup 168}Yb have been determined by Penning-trap mass-ratio measurements. Based on our new high-precision results for the Q values, neither of these transitions shows a resonant enhancement of the capture rate. At present, this excludes these nuclides from the list of suitable candidates in the search for neutrinoless double-electron capture.

  14. Silver nanoparticles enhanced luminescence properties of Er{sup 3+} doped tellurite glasses: Effect of heat treatment

    SciTech Connect (OSTI)

    Fares, Hssen; Frid, Mokhtar [Laboratoire de Physico-Chimie des Matriaux Minraux et leurs Applications, Centre National de Recherches en Sciences des Matriaux, B.P. 95 Hammam-Lif, 2050 (Tunisia); Elhouichet, Habib, E-mail: habib.elhouichet@fst.rnu.tn [Laboratoire de Physico-Chimie des Matriaux Minraux et leurs Applications, Centre National de Recherches en Sciences des Matriaux, B.P. 95 Hammam-Lif, 2050 (Tunisia); Department of Physics, Sciences Faculty of Tunis, University Tunis ElManar 2092 (Tunisia); Gelloz, Bernard [Graduate School of Engineering, Nagoya University, 2-24-16 Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8603 (Japan)

    2014-09-28T23:59:59.000Z

    Tellurite glasses doped Er{sup 3+} ions and containing Silver nanoparticles (Ag NPs) are prepared using melt quenching technique. The nucleation and growth of Ag NPs were controlled by a thermal annealing process. The X-ray diffraction pattern shows no sharp peak indicating an amorphous nature of the glasses. The presence of Ag NPs is confirmed from transmission electron microscopy micrograph. Absorption spectra show typical surface plasmon resonance (SPR) band of Ag NPs within the 510550?nm range in addition to the distinctive absorption peaks of Er{sup 3+} ions. The Judd-Ofelt (J-O) intensity parameters, oscillator strengths, spontaneous transition probabilities, branching ratios, and radiative lifetimes were successfully calculated based on the experimental absorption spectrum and the J-O theory. It was found that the presence of silver NPs nucleated and grown during the heat annealing process improves both of the photoluminescence (PL) intensity and the PL lifetime relative to the {sup 4}I{sub 13/2}???{sup 4}I{sub 15/2} transition. Optimum PL enhancement was obtained after 10?h of heat-treatment. Such enhancements are mainly attributed to the strong local electric field induced by SPR of silver NPs and also to energy transfer from the surface of silver NPs to Er{sup 3+} ions, whereas the quenching is ascribed to the energy transfer from Er{sup 3+} ions to silver NPs. Using the Mc Cumber method, absorption cross-section, calculated emission cross-section, and gain cross-section for the {sup 4}I{sub 13/2} ? {sup 4}I{sub 15/2} transition were determined and compared for the doped and co-doped glasses. The present results indicate that the glass heat-treated for 10?h has good prospect as a gain medium applied for 1.53??m band broad and high-gain erbium-doped fiber amplifiers.

  15. Gain dynamics in a soft X-ray laser ampli er perturbed by a strong injected X-ray eld

    SciTech Connect (OSTI)

    Wang, Yong [Colorado State University, Fort Collins] [Colorado State University, Fort Collins; Wang, Shoujun [Colorado State University, Fort Collins] [Colorado State University, Fort Collins; Oliva, E [Laboratoire de Physique des Gaz et des Gaz et des Plasmas] [Laboratoire de Physique des Gaz et des Gaz et des Plasmas; Lu, L [Laboratoire de Physique des Gaz et des Gaz et des Plasmas] [Laboratoire de Physique des Gaz et des Gaz et des Plasmas; Berrill, Mark A [ORNL] [ORNL; Yin, Liang [Colorado State University, Fort Collins] [Colorado State University, Fort Collins; Nejdl, J [Colorado State University, Fort Collins] [Colorado State University, Fort Collins; Luther, Brad [Colorado State University, Fort Collins] [Colorado State University, Fort Collins; Proux, C [Laboratoire dOptique Appliquee, ENSTA, CNRS, Ecole Polytechnique] [Laboratoire dOptique Appliquee, ENSTA, CNRS, Ecole Polytechnique; Le, T. T. [Laboratoire de Physique des Gaz et des Gaz et des Plasmas] [Laboratoire de Physique des Gaz et des Gaz et des Plasmas; Dunn, James [Lawrence Livermore National Laboratory (LLNL)] [Lawrence Livermore National Laboratory (LLNL); Ros, D [Laboratoire de Physique des Gaz et des Gaz et des Plasmas] [Laboratoire de Physique des Gaz et des Gaz et des Plasmas; Zeitoun, Philippe [cole Polytechnique] [cole Polytechnique; Rocca, Jorge [Colorado State University, Fort Collins] [Colorado State University, Fort Collins

    2014-01-01T23:59:59.000Z

    Seeding soft X-ray plasma ampli ers with high harmonics has been demonstrated to generate high-brightness soft X-ray laser pulses with full spatial and temporal coherence. The interaction between the injected coherent eld and the swept-gain medium has been modelled. However, no exper- iment has been conducted to probe the gain dynamics when perturbed by a strong external seed eld. Here, we report the rst X-ray pump X-ray probe measurement of the nonlinear response of a plasma ampli er perturbed by a strong soft X-ray ultra-short pulse. We injected a sequence of two time-delayed high-harmonic pulses (l518.9 nm) into a collisionally excited nickel-like molybdenum plasma to measure with femto-second resolution the gain depletion induced by the saturated ampli cation of the high-harmonic pump and its subsequent recovery. The measured fast gain recovery in 1.5 1.75 ps con rms the possibility to generate ultra-intense, fully phase-coherent soft X-ray lasers by chirped pulse ampli cation in plasma ampli ers.

  16. Spectroscopic properties of Er{sup 3+} doped lead telluroborate glasses for 1.5 ?m broadband amplifiers

    SciTech Connect (OSTI)

    Vijayakumar, R., E-mail: mari-ram2000@yahoo.com; Arunkumar, S., E-mail: mari-ram2000@yahoo.com; Vijayakumar, M., E-mail: mari-ram2000@yahoo.com; Marimuthu, K., E-mail: mari-ram2000@yahoo.com [Department of Physics, Gandhigram Rural Institute ? Deemed University, Gandhigram - 624302 (India)

    2014-04-24T23:59:59.000Z

    Er{sup 3+} doped lead telluroborate glasses (xEPTB) with the composition 25B{sub 2}O{sub 3}-(25-x)TeO{sub 2}-25PbO-10Bi{sub 2}O{sub 3}-15CdO-xEr{sub 2}O{sub 3} (where x=0.1, 0.5, 1 and 2 wt%) have been prepared and characterised using NIR luminescence and decay measurements for 1.5 ?m broadband amplifier applications. Judd-Ofelt intensity parameters have been derived to predict radiative properties of the {sup 4}I{sub 13/2}?{sup 4}I{sub 15/2} emission transition. The larger values of stimulated emission cross-section (?P), FWHM, gain bandwidth (?G), radiative lifetime (?{sup cal}), quantum efficiency (?) of the 1EPTB glass suggest their potential use in broadband amplifiers. The effect of RE ion concentration and OH{sup ?} content on the lifetime of {sup 4}I{sub 13/2}?{sup 4}I{sub 15/2} transition and the energy transfer mechanism of Er{sup 3+} ions have also been discussed and reported in the present study.

  17. Optical absorption and fluorescence properties of Er{sup 3+}/Yb{sup 3+} codoped lead bismuth alumina borate glasses

    SciTech Connect (OSTI)

    Goud, K. Krishna Murthy, E-mail: krishnamurthy.phy@gmail.com; Reddy, M. Chandra Shekhar, E-mail: krishnamurthy.phy@gmail.com; Rao, B. Appa, E-mail: krishnamurthy.phy@gmail.com [Dept. of Physics, Osmania University, Hyderabad-500007, Andhra Pradesh (India)

    2014-04-24T23:59:59.000Z

    Lead bismuth alumina borate glasses codoped with Er{sup 3+}/Yb{sup 3+} were prepared by melt quenching technique. Optical absorption, FTIR and photoluminescence spectra of these glasses have been studied. Judd-Ofelt theory has been applied to to the f ? f transitions for evaluating ?{sub 2}, ?{sub 4} and ?{sub 6} parameters. Radiative properties like branching ratio ?{sub r} and the radiative life time ?{sub R} have been determined on the basis of Judd-Ofelt theory. Upconversion emissions have been observed under 980nm laser excitation at room temperature. Green and red up-conversion emissions are centered at 530, 550 and 656 nm corresponding to {sup 2}H{sub 11/2}?{sup 4}I{sub 15/2}, {sup 4}S{sub 3/2}?{sup 4}I{sub 15/2} and {sup 4}F{sub 9/2}?{sup 4}I{sub 15/2} transitions of Er{sup 3+} respectively. The results obtained are discussed quantitatively based on the energy transfer between Yb{sup 3+} and Er{sup 3+}.

  18. Photoluminescence properties and energy levels of RE (RE?=?Pr, Sm, Er, Tm) in layered-CaZnOS oxysulfide

    SciTech Connect (OSTI)

    Zhang, Zhi-Jun, E-mail: zhangzj@mail.sic.ac.cn [Key Laboratory of Transparent Opto-Functional Inorganic Materials of Chinese Academy of Sciences, Shanghai Institute of Ceramics, Shanghai 200050 (China); Feng, Ang; Chen, Xiang-Yang [Key Laboratory of Transparent Opto-Functional Inorganic Materials of Chinese Academy of Sciences, Shanghai Institute of Ceramics, Shanghai 200050 (China); University of Chinese Academy of Sciences, Beijing 100039 (China); Zhao, Jing-Tai, E-mail: jtzhao@mail.sic.ac.cn [Key Laboratory of Transparent Opto-Functional Inorganic Materials of Chinese Academy of Sciences, Shanghai Institute of Ceramics, Shanghai 200050 (China); School of Materials Science and Engineering, Shanghai University, Shanghai 200072 (China)

    2013-12-07T23:59:59.000Z

    RE{sup 3+} (RE?=?Pr, Sm, Er, Tm)-activated CaZnOS samples were prepared by a solid-state reaction method at high temperature, and their photoluminescence properties were investigated. Doping with RE{sup 3+} (RE?=?Pr, Sm, Er, Tm) into layered-CaZnOS resulted in typical RE{sup 3+} (RE?=?Pr, Sm, Er, Tm) f-f line absorptions and emissions, as well as the charge transfer band of Sm{sup 3+} at about 3.3?eV. The energy level scheme containing the position of the 4f and 5d levels of all divalent and trivalent lanthanide ions with respect to the valence and conduction bands of CaZnOS has been constructed based on the new data presented in this work, together with the data from literature on Ce{sup 3+} and Eu{sup 2+} doping in CaZnOS. The detailed energy level scheme provides a platform for interpreting the optical spectra and could be used to comment on the valence stability of the lanthanide ions in CaZnOS.

  19. Interaction of Ce{sub 1?x}Er{sub x}O{sub 2?y} nanoparticles with SiO{sub 2}-effect of temperature and atmosphere

    SciTech Connect (OSTI)

    Kepinski, L., E-mail: L.Kepinski@int.pan.wroc.pl; Krajczyk, L.; Mista, W.

    2014-01-15T23:59:59.000Z

    Morphology, microstructure and phase evolution of homogeneous, nanocrystalline Ce{sub 1?x}Er{sub x}O{sub 2?x/2} mixed oxide (x=0.3 and 0.5), prepared by microemulsion method, supported on amorphous SiO{sub 2} was studied in oxidizing and reducing atmosphere by XRD, TEM, SEM-EDS and N{sub 2} adsorption. The system is structurally and chemically stable in the oxidizing atmosphere up to 1000 C, exhibiting only a small increase of the mean crystallite size of the oxide to ?4 nm. At 1100 C formation of Er silicate with unusual structure isomorphic with y-Y{sub 2}Si{sub 2}O{sub 7} (yttrialite), stabilized by Ce{sup 4+} ions was observed. In the reducing atmosphere the Ce{sub 1?x}Er{sub x}O{sub 2?x/2} reacted with SiO{sub 2} already at 900 C, due to high affinity of the reduced Ce{sup 3+} to form a silicate phase. At higher temperature the silicate crystallized into the tetragonal, low temperature A-(Ce{sub 1?x}Er{sub x}){sub 2}Si{sub 2}O{sub 7} polymorph. Such systems, containing nanocrystalline silicate particles with Er{sup 3+} ions placed in well defined sites embedded in silica matrix, may be interesting as highly efficient active components of optical waveguides amplifiers integrated with Si microelectronics. The nanocrystalline CeErO/SiO{sub 2} system prepared by the impregnation of the silica with the aqueous solution of nitrates appeared to be chemically inhomogeneous and less stable in both oxidising and reducing atmosphere. - Graphical abstract: Structure evolution of Ce{sub 0.5}Er{sub 0.5}O{sub 1.75} in air and in H{sub 2}. Display Omitted - Highlights: Homogeneous 3 nm Ce{sub 1?x}Er{sub x}O{sub 2?y} particles were prepared and uniformly dispersed on SiO{sub 2}. Er diffusion to SiO{sub 2} determines the stability of the mixed oxide in air to ?1000 C. Spreading of Ce{sub 1?x}Er{sub x}O{sub 2?y} onto SiO{sub 2} occurs in hydrogen at 900 C. Nanocrystalline A-(Ce,Er){sub 2}Si{sub 2}O{sub 7} silicate forms in H{sub 2} at 1100 C.

  20. Identification of remediation needs and technology development focus areas for the Environmental Restoration (ER) Project at Sandia National Laboratories/New Mexico (SNL/NM)

    SciTech Connect (OSTI)

    Tucker, M.D. [Sandia National Labs., Albuquerque, NM (United States). Site Restoration Technology Program Office; Valdez, J.M.; Khan, M.A. [IT Corp., Albuquerque, NM (United States)

    1995-06-01T23:59:59.000Z

    The Environmental Restoration (ER) Project has been tasked with the characterization, assessment, remediation and long-term monitoring of contaminated waste sites at Sandia National Laboratories/New Mexico (SNL/NM). Many of these sites will require remediation which will involve the use of baseline technologies, innovative technologies that are currently under development, and new methods which will be developed in the near future. The Technology Applications Program (TAP) supports the ER Project and is responsible for development of new technologies for use at the contaminated waste sites, including technologies that will be used for remediation and restoration of these sites. The purpose of this report is to define the remediation needs of the ER Project and to identify those remediation needs for which the baseline technologies and the current development efforts are inadequate. The area between the remediation needs and the existing baseline/innovative technology base represents a technology gap which must be filled in order to remediate contaminated waste sites at SNL/NM economically and efficiently. In the first part of this report, the remediation needs of the ER Project are defined by both the ER Project task leaders and by TAP personnel. The next section outlines the baseline technologies, including EPA defined Best Demonstrated Available Technologies (BDATs), that are applicable at SNL/NM ER sites. This is followed by recommendations of innovative technologies that are currently being developed that may also be applicable at SNL/NM ER sites. Finally, the gap between the existing baseline/innovative technology base and the remediation needs is identified. This technology gap will help define the future direction of technology development for the ER Project.

  1. Role of estrogen receptor alpha (ER alpha) insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells

    E-Print Network [OSTI]

    Zhang, Shu

    2009-05-15T23:59:59.000Z

    ROLE OF ESTROGEN RECEPTOR ? (ER?) IN INSULIN-LIKE GROWTH FACTOR (IGF)-I-INDUCED RESPONSES IN MCF-7 BREAST CANCER CELLS A Dissertation by SHU ZHANG Submitted to the Office of Graduate Studies of Texas A&M University in partial... fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY December 2007 Major Subject: Toxicology ROLE OF ESTROGEN RECEPTOR ? (ER?) IN INSULIN-LIKE GROWTH FACTOR (IGF)-I-INDUCED RESPONSES IN MCF-7 BREAST CANCER CELLS A Dissertation...

  2. Final Report for DOE Grant DE-FG02-06ER64160 Retrieval of Cloud Properties and Direct Testing of Cloud and Radiation Parameterizations using ARM Observations.

    SciTech Connect (OSTI)

    Donovan, David Patrick [KNMI

    2013-07-26T23:59:59.000Z

    This report briefly summaries the work performed at KNMI under DOE Grant DE-FG02-06ER64160 which, in turn was conducted in support of DOE Grant DE-FG02-90ER61071 lead by E. Clothieux of Penn. State U. The specific work at KNMI revolved around the development and application of the EarthCARE simulator to ground-based multi-sensor simulations.

  3. WBS-FOR CREATING AN ER-MODEL Let A(Ei) = the set of attributes of entity-set an Ei.

    E-Print Network [OSTI]

    Kundu, Sukhamay

    WBS-FOR CREATING AN ER-MODEL Let A(Ei) = the set of attributes of entity-set an Ei. Let A from each Ei partici- pating in Rj, can interact multiple times, then we need a pri- mary key among FOR CREATING ER-MODELS Identify name and A(Ei) for each Ei Identify a primary key for each Ei Identify name

  4. Intermittent hypoxia induces the proliferation of rat vascular smooth muscle cell with the increases in epidermal growth factor family and erbB2 receptor

    SciTech Connect (OSTI)

    Kyotani, Yoji, E-mail: cd147@naramed-u.ac.jp [Department of Pharmacology, Nara Medical University School of Medicine, Kashihara 634-8521 (Japan); Department of Pharmacy, Nara Medical University Hospital, Kashihara 634-8522 (Japan); Ota, Hiroyo [Second Department of Internal Medicine, Nara Medical University School of Medicine, Kashihara 634-8522 (Japan); Department of Biochemistry, Nara Medical University School of Medicine, Kashihara 634-8521 (Japan); Itaya-Hironaka, Asako; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo [Department of Biochemistry, Nara Medical University School of Medicine, Kashihara 634-8521 (Japan); Zhao, Jing; Ozawa, Kentaro; Nagayama, Kosuke; Ito, Satoyasu [Department of Pharmacology, Nara Medical University School of Medicine, Kashihara 634-8521 (Japan); Takasawa, Shin [Department of Biochemistry, Nara Medical University School of Medicine, Kashihara 634-8521 (Japan); Kimura, Hiroshi [Second Department of Internal Medicine, Nara Medical University School of Medicine, Kashihara 634-8522 (Japan); Uno, Masayuki [Department of Pharmacy, Nara Medical University Hospital, Kashihara 634-8522 (Japan); Yoshizumi, Masanori [Department of Pharmacology, Nara Medical University School of Medicine, Kashihara 634-8521 (Japan)

    2013-11-15T23:59:59.000Z

    Obstructive sleep apnea is characterized by intermittent hypoxia (IH), and associated with cardiovascular diseases, such as stroke and heart failure. These cardiovascular diseases have a relation to atherosclerosis marked by the proliferation of vascular smooth muscle cells (VSMCs). In this study, we investigated the influence of IH on cultured rat aortic smooth muscle cell (RASMC). The proliferation of RASMC was significantly increased by IH without changing the level of apoptosis. In order to see what induces RASMC proliferation, we investigated the influence of normoxia (N)-, IH- and sustained hypoxia (SH)-treated cell conditioned media on RASMC proliferation. IH-treated cell conditioned medium significantly increased RASMC proliferation compared with N-treated cell conditioned medium, but SH-treated cell conditioned medium did not. We next investigated the epidermal growth factor (EGF) family as autocrine growth factors. Among the EGF family, we found significant increases in mRNAs for epiregulin (ER), amphiregulin (AR) and neuregulin-1 (NRG1) in IH-treated cells and mature ER in IH-treated cell conditioned medium. We next investigated the changes in erbB family receptors that are receptors for ER, AR and NRG1, and found that erbB2 receptor mRNA and protein expressions were increased by IH, but not by SH. Phosphorylation of erbB2 receptor at Tyr-1248 that mediates intracellular signaling for several physiological effects including cell proliferation was increased by IH, but not by SH. In addition, inhibitor for erbB2 receptor suppressed IH-induced cell proliferation. These results provide the first demonstration that IH induces VSMC proliferation, and suggest that EGF family, such as ER, AR and NRG1, and erbB2 receptor could be involved in the IH-induced VSMC proliferation. - Highlights: ?In vitro system for intermittent hypoxia (IH) and sustained hypoxia (SH). ?IH, but not SH, induces the proliferation of rat vascular smooth muscle cell. ?Epiregulin mRNA and protein are up-regulated in IH, but not in SH. ?IH-induced erbB2 phosphorylation is attenuated by erbB2 inhibitor. ?EGF family and erbB2 receptor may be involved in IH-induced cell proliferation.

  5. Completion Report for Model Evaluation Well ER-5-5: Corrective Action Unit 98: Frenchman Flat

    SciTech Connect (OSTI)

    NSTec Underground Test Area and Boreholes Programs and Operations

    2013-01-18T23:59:59.000Z

    Model Evaluation Well ER-5-5 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of Nevada Environmental Management Operations at the Nevada National Security Site (formerly known as the Nevada Test Site). The well was drilled in July and August 2012 as part of a model evaluation well program in the Frenchman Flat area of Nye County, Nevada. The primary purpose of the well was to provide detailed geologic, hydrogeologic, chemical, and radiological data that can be used to test and build confidence in the applicability of the Frenchman Flat Corrective Action Unit flow and transport models for their intended purpose. In particular, this well was designed to obtain data to evaluate the uncertainty in model forecasts of contaminant migration from the upgradient underground nuclear test MILK SHAKE, conducted in Emplacement Hole U-5k in 1968, which were considered to be uncertain due to the unknown extent of a basalt lava-flow aquifer present in this area. Well ER-5-5 is expected to provide information to refine the Phase II Frenchman Flat hydrostratigraphic framework model, if necessary, as well as to support future groundwater flow and transport modeling. The 31.1-centimeter (cm) diameter hole was drilled to a total depth of 331.3 meters (m). The completion string, set at the depth of 317.2 m, consists of 16.8-cm stainless-steel casing hanging from 19.4-cm carbon-steel casing. The 16.8-cm stainless-steel casing has one slotted interval open to the basalt lava-flow aquifer and limited intervals of the overlying and underlying alluvial aquifer. A piezometer string was also installed in the annulus between the completion string and the borehole wall. The piezometer is composed of 7.3-cm stainless-steel tubing suspended from 6.0-cm carbon-steel tubing. The piezometer string was landed at 319.2 m, to monitor the basalt lava-flow aquifer. Data collected during and shortly after hole construction include composite drill cuttings samples collected every 3.0 m, various geophysical logs, preliminary water quality measurements, and water-level measurements. The well penetrated 331.3 m of QuaternaryTertiary alluvium, including an intercalated layer of saturated basalt lava rubble. No well development or hydrologic testing was conducted in this well immediately after completion; however, a preliminary water level was measured in the piezometer string at the depth of 283.4 m on September 25, 2012. No tritium above the minimum detection limit of the field instruments was detected in this hole. Future well development, sampling, and hydrologic testing planned for this well will provide more accurate hydrologic information for this site. The stratigraphy, general lithology, and water level were as expected, though the expected basalt lava-flow aquifer is basalt rubble and not the dense, fractured lava as modeled. The lack of tritium transport is likely due to the difference in hydraulic properties of the basalt lava-flow rubble encountered in the well, compared to those of the fractured aquifer used in the flow and transport models.

  6. Idaho National Engineering Laboratory (INEL) Environmental Restoration (ER) Program Baseline Safety Analysis File (BSAF)

    SciTech Connect (OSTI)

    NONE

    1995-09-01T23:59:59.000Z

    The Baseline Safety Analysis File (BSAF) is a facility safety reference document for the Idaho National Engineering Laboratory (INEL) environmental restoration activities. The BSAF contains information and guidance for safety analysis documentation required by the U.S. Department of Energy (DOE) for environmental restoration (ER) activities, including: Characterization of potentially contaminated sites. Remedial investigations to identify and remedial actions to clean up existing and potential releases from inactive waste sites Decontamination and dismantlement of surplus facilities. The information is INEL-specific and is in the format required by DOE-EM-STD-3009-94, Preparation Guide for U.S. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports. An author of safety analysis documentation need only write information concerning that activity and refer to BSAF for further information or copy applicable chapters and sections. The information and guidance provided are suitable for: {sm_bullet} Nuclear facilities (DOE Order 5480-23, Nuclear Safety Analysis Reports) with hazards that meet the Category 3 threshold (DOE-STD-1027-92, Hazard Categorization and Accident Analysis Techniques for Compliance with DOE Order 5480.23, Nuclear Safety Analysis Reports) {sm_bullet} Radiological facilities (DOE-EM-STD-5502-94, Hazard Baseline Documentation) Nonnuclear facilities (DOE-EM-STD-5502-94) that are classified as {open_quotes}low{close_quotes} hazard facilities (DOE Order 5481.1B, Safety Analysis and Review System). Additionally, the BSAF could be used as an information source for Health and Safety Plans and for Safety Analysis Reports (SARs) for nuclear facilities with hazards equal to or greater than the Category 2 thresholds, or for nonnuclear facilities with {open_quotes}moderate{close_quotes} or {open_quotes}high{close_quotes} hazard classifications.

  7. Enhanced 1.53??m emission of Er{sup 3+} ions in phosphate glass via energy transfer from Cu{sup +} ions

    SciTech Connect (OSTI)

    Jimnez, Jos A., E-mail: jose.jimenez@unf.edu [Department of Chemistry, University of North Florida, Jacksonville, Florida 32224 (United States); Sendova, Mariana [Optical Spectroscopy and Nano-Materials Lab, New College of Florida, Sarasota, Florida 34243 (United States)

    2014-07-21T23:59:59.000Z

    Optimizing the efficiency of Er{sup 3+} emission in the near-infrared telecommunication window in glass matrices is currently a subject of great interest in photonics research. In this work, Cu{sup +} ions are shown to be successfully stabilized at a high concentration in Er-containing phosphate glass by a single-step melt-quench method, and demonstrated to transfer energy to Er{sup 3+} thereby enhancing the near-infrared emission about 15 times. The spectroscopic data indicate an energy conversion process where Cu{sup +} ions first absorb photons broadly around 360?nm and subsequently transfer energy from the Stokes-shifted emitting states to resonant Er{sup 3+} absorption transitions in the visible. Consequently, the Er{sup 3+} electronic excited states decay and the {sup 4}I{sub 3/2} metastable state is populated, leading to the enhanced emission at 1.53??m. Monovalent copper ions are thus recognized as sensitizers of Er{sup 3+} ions, suggesting the potential of Cu{sup +} co-doping for applications in the telecommunications, solar cells, and solid-state lasing realizable under broad band near-ultraviolet optical pumping.

  8. Magnetic properties and magnetocaloric effects of Gd{sub x}Er{sub 1?x}Ga (0???x???1) compounds

    SciTech Connect (OSTI)

    Zheng, X. Q.; Wang, L. C.; Wu, R. R.; Hu, F. X.; Sun, J. R.; Shen, B. G., E-mail: shenbg@aphy.iphy.ac.cn [Institute of Physics, State key laboratory for Magnetism, Chinese Academy of Sciences, Beijing 100190 (China); Chen, J. [Beijing Institute of Aerospace Testing Technology, China Aerospace Science and Technology Corporation, Beijing 100074 (China)

    2014-05-07T23:59:59.000Z

    We carefully studied the magnetic properties and magnetocaloric effect of Gd{sub x}Er{sub 1-x}Ga (0???x???1) compounds. The Gd{sub x}Er{sub 1-x}Ga compounds undergo two magnetic transitions with temperature increasing: spin-reorientation or antiferromagnetic-to-ferromagnetic (FM) transition and FM-to-paramagnetic transition. As the content of Gd increases from 0 to 1, the transition temperature in low temperature region changes from 15?K to 66?K and the Curie temperature increases obviously from 30?K to 181.9?K. Although the maximum value of magnetic entropy change (?S{sub M}) for Gd{sub x}Er{sub 1?x}Ga decreases with the increase of x, the refrigerant capacity (RC) improves remarkably compared with that of ErGa compound. Table-like ?S{sub M} curves are observed for the compounds with x?=?0.1, 0.2, 0.3, and 0.4, which are very useful for real cooling applications. And Gd{sub 0.2}Er{sub 0.8}Ga and Gd{sub 0.3}Er{sub 0.7}Ga compounds show better magnetocaloric features than others in this series under considerations of both ?S{sub M} and RC. The results of this series of compounds show us a possible way to design and improve the magnetic refrigerant materials by making some substitutions.

  9. Long-range ferromagnetic order induced by a donor impurity band exchange in SnO{sub 2}:Er{sup 3+} nanoparticles

    SciTech Connect (OSTI)

    Aragn, F. H.; Coaquira, J. A. H. [Ncleo de Fsica Aplicada, Institute of Physics, University of Braslia, Braslia DF 70910-900 (Brazil); Chitta, V. A. [Instituto de Fsica, Universidade de So Paulo, So Paulo, SP 05508-000 (Brazil); Hidalgo, P. [Faculdade Gama-FGA, Sector Central Gama, Universidade de Braslia, Braslia, DF72405-610 (Brazil); Brito, H. F. [Instituto de Qumica, Universidade de So Paulo, So Paulo, SP 05508-000 (Brazil)

    2013-11-28T23:59:59.000Z

    In this work, the structural and magnetic properties of Er-doped SnO{sub 2} (SnO{sub 2}:Er) nanoparticles are reported. The SnO{sub 2}:Er nanoparticles have been synthesized by a polymer precursor method with Er content from 1.0% to 10.0%. X-ray diffraction results indicate the formation of only the rutile-type structure in all samples. The estimated mean crystallite size shows a decrease from ?10 to ?4?nm when the Er content is increased from 1.0% to 10.0%. The particle size values have been corroborated by transmission electron microscopy technique. The thermal dependence of the magnetization is consistent with the 3+ oxidation state of erbium ions for all samples. A strong paramagnetic-like behavior coexisting with a ferromagnetic phase has been determined for samples with Er content below 5.0%. Above this concentration, only a paramagnetic behavior has been determined. Isothermal magnetization curves are consistent with the occurrence of long-range ferromagnetic order mediated by donor electrons forming bound magnetic polarons which overlap to produce a spin-split impurity band.

  10. Upcoversion performance improvement of NaYF{sub 4}:Yb, Er by Sn codoping: Enhanced emission intensity and reduced decay time

    SciTech Connect (OSTI)

    Yu, Han, E-mail: fjfzyh@fzu.edu.cn [College of Materials Science and Engineering, Fuzhou University, Fuzhou, Fujian 350108 (China); Cao, Wenbing [College of Materials Science and Engineering, Fuzhou University, Fuzhou, Fujian 350108 (China); Huang, Qingming [Instrumentation Analysis and Research Center, Fuzhou University, Fuzhou, Fujian 350002 (China); Ma, En [Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002 (China); Zhang, Xinqi [Instrumentation Analysis and Research Center, Fuzhou University, Fuzhou, Fujian 350002 (China); Yu, Jianchang [College of Materials Science and Engineering, Fuzhou University, Fuzhou, Fujian 350108 (China)

    2013-11-15T23:59:59.000Z

    In this manuscript we report a phenomenon that upconversion emission intensity of Er{sup 3+} was enhanced while decay time constant was decreased obviously by Sn codoping with Yb/Er into hexagonal NaYF{sub 4} synchronously. X-ray powder diffiraction, field emission scanning electron microscope, transmission electron microscopy, X-ray photoelectron spectroscopy, electron spin-resonance spectroscopy and upconversion emission spectra were employed to explore the relation of crystal structure and properties. From these characterizations we found that symmetry of the rare earth ion local crystal field could be tuned by different Sn codoping concentration. For the variable valence property of Sn the local crystal field asymmetry and emission intensity of NaYF{sub 4}:Yb, Er arrived to the maximum when 3 mol% Sn was codoped, while decay time was reduced. The study of this changing tends of upconversion emission intensity and decay time constant may be helpful for design and fabrication of high performance upconversion materials. - Graphical abstract: Variable-valenced Sn is introduced with Yb/Er into NaFY{sub 4} to tune structure and local crystal field. Upconversion emission intensity of Er{sup 3+} was enhanced while decay time constant was decreased. Display Omitted - Highlights: NaYF{sub 4}: Yb, Er was codoped with different concentration Sn. Upconversion emission intensity was enhanced while decay time constant was decreased. Introduction of variable-valenced Sn is effective to tune structure and crystal field of NaFY{sub 4}.

  11. Structural and ambient/sub-ambient temperature magnetic properties of Er-substituted cobalt-ferrites synthesized by sol-gel assisted auto-combustion method

    SciTech Connect (OSTI)

    Prathapani, Sateesh [School of Engineering Sciences and Technology, University of Hyderabad, Hyderabad 500046 (India); Department of Metallurgical Engineering and Materials Science, IIT-Bombay, Mumbai 400076 (India); Jayaraman, Tanjore V., E-mail: ddas@uohyd.ernet.in, E-mail: tvjayaraman@gmail.com [Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, Nebraska 68588 (United States); Varaprasadarao, Eswara K. [Department of Metallurgical Engineering and Materials Science, IIT-Bombay, Mumbai 400076 (India); Das, Dibakar, E-mail: ddas@uohyd.ernet.in, E-mail: tvjayaraman@gmail.com [School of Engineering Sciences and Technology, University of Hyderabad, Hyderabad 500046 (India)

    2014-07-14T23:59:59.000Z

    Er-substituted cobalt-ferrites CoFe{sub 2?x}Er{sub x}O{sub 4} (0???x???0.04) were synthesized by sol-gel assisted auto-combustion method. The precursor powders were calcined at 673873?K for 4?h, subsequently pressed into pellets and sintered at 1273?K for 4?h. X-ray diffraction (XRD) confirmed the presence of the spinel phase for all the compositions and, additional orthoferrite phase for higher compositions (x?=?0.03 and 0.04). The XRD spectra and the Transmission Electron Microscopy micrographs indicate that the nanocrystalline particulates of the Er-substituted cobalt ferrites have crystallite size of ?120200?nm. The magnetization curves show an increase in saturation magnetization (M{sub S}) and coercivity (H{sub C}) for Er-substituted cobalt-ferrites at sub-ambient temperatures. M{sub S} for CoFe{sub 2}O{sub 4}, CoFe{sub 0.99}Er{sub 0.01}O{sub 4}, CoFe{sub 0.98}Er{sub 0.02}O{sub 4}, and CoFe{sub 0.97}Er{sub 0.03}O{sub 4} peak at 89.7?Am{sup 2}/kg, 89.3?Am{sup 2}/kg, 88.8?Am{sup 2}/kg, and 87.1?Am{sup 2}/kg, respectively, at a sub-ambient temperature of ?150?K. H{sub C} substantially increases with decrease in temperature for all the compositions, while it peaks at x?=?0.01?0.02 at all temperatures. The combination of Er contentx???0.02 and the temperature?5?K provides the maximum H{sub C}???984?kA/m. Er-substituted cobalt-ferrites have higher cubic anisotropy constant, K{sub 1}, compared to pure cobalt-ferrite at ambient/sub-ambient temperatures. K{sub 1} gradually increases for all compositions in the temperature decreasing from 300 to 100?K. While K{sub 1} peaks at ?150?K for pure cobalt-ferrite, it peaks at ?50?K for CoFe{sub 0.99}Er{sub 0.01}O{sub 4}, CoFe{sub 0.98}Er{sub 0.02}O{sub 4}, and CoFe{sub 0.96}Er{sub 0.04}O{sub 4}. The M{sub S} (?88.7?Am{sup 2}/kg), at 5?K, for Er substituted cobalt-ferrite is close to the highest values reported for Sm and Gd substituted cobalt-ferrites. The M{sub S} (?83.5?Am{sup 2}/kg) at 300?K for Er-substituted cobalt-ferrite is the highest among the lanthanide series element substituted cobalt-ferrites. The H{sub C} (at 5?K) for Er substituted cobalt-ferrite is close to the highest values observed for La, Ce, Nd, Sm, and Gd substituted cobalt-ferrites.

  12. Arginine metabolism in enterocytes of diabetic rats

    E-Print Network [OSTI]

    Morrow, Natalie Anne

    2002-01-01T23:59:59.000Z

    Diabetic rats and patients exhibit decreased plasma arginine concentrations. Arginine is important in numerous cellular pathways, including the synthesis of nitric oxide and the release of insulin from pancreatic ? cells. At present, little...

  13. The Metabolism of Curium in the RAT

    E-Print Network [OSTI]

    Hamilton, J.

    2010-01-01T23:59:59.000Z

    G. , "The Metabolism of Americium in the Rat", Jour. Clin.of the metabOlism of americium has been reported in.is also radloacti ve. Americium and curium are not available

  14. Special features of the excitation spectra and kinetics of photoluminescence of the Si{sub 1-x}Ge{sub x}:Er/Si structures with relaxed heterolayers

    SciTech Connect (OSTI)

    Krasilnikova, L. V., E-mail: Luda@ipm.sci-nnov.ru; Yablonskiy, A. N.; Stepikhova, M. V.; Drozdov, Yu. N. [Russian Academy of Sciences, Institute for Physics of Microstructures (Russian Federation); Shengurov, V. G. [Lobachevsky State University, Physicotechnical Research Institute (Russian Federation); Krasilnik, Z. F. [Russian Academy of Sciences, Institute for Physics of Microstructures (Russian Federation)

    2010-11-15T23:59:59.000Z

    Luminescent properties of heteroepitaxial Si{sub 1-x}Ge{sub x}:Er/Si structures with relaxed heterolayers are studied. The results of combined studies of the excitation spectra and kinetics of photoluminescence (PL) are used to single out the components providing the largest contribution to the PL signal of the Si{sub 1-x}Ge{sub x}:Er/Si structures in the wavelength region of 1.54 {mu}m. It is shown that relaxation of elastic stresses in the Si{sub 1-x}Ge{sub x}:Er heterolayer affects only slightly the kinetic characteristics of erbium luminescence and manifests itself in insignificant contribution of the defects and defect-impurity complexes to the luminescent response of the Si{sub 1-x}Ge{sub x}:Er/Si structures. In the excitation spectra of the erbium PL, special features related to the possibility of the rare-earth impurity excitation at energies lower than the band gap of the Si{sub 1} {sub -x}Ge{sub x} solid solution are revealed. It is shown that a peak the width of which depends on the band gap of the solid solution and the extent of its relaxation is observed in the excitation spectra of the erbium-related PL in the Si{sub 1-x}Ge{sub x}:Er/Si structures in the wavelength region of 1040-1050 nm. The observed specific features are accounted for by involvement of intermediate levels in the band gap of the Si{sub 1-x}Ge{sub x}:Er solid solution in the process of excitation of an Er{sup 3+} ion.

  15. Final Report for DOE grant project FG02-07ER41458 [Dense Quark Matter in Magnetic Fields

    SciTech Connect (OSTI)

    Incera, Vivian

    2012-01-24T23:59:59.000Z

    Final Report for DOE grant DE-FG02-07ER41458. This grant was originally a three-year project. However, this final report summarizes the results of the first two years, as at the end of the second year of the grant the PIs moved to a new university and the grant was closed. The work done under the first two years of the DOE grant led to several papers and presentations. It also served to train one undergraduate and three graduate students.

  16. Huntingtin is required for ER-to-Golgi transport and for secretory vesicle fusion at the plasma membrane

    E-Print Network [OSTI]

    Brandstaetter, Hemma; Kruppa, Antonina J.; Buss, Folma

    2014-10-31T23:59:59.000Z

    et al., 2009; Presley et al., 1997; Roghi and Allan, 1999). To determine whether compromising dynein activity affects the ER-to-Golgi GFP-hGH transport assay, we performed siRNA knockdown of the dynein associated intermediate chain (DIC... cells. Nature. 389:81-85. Roghi, C., and V.J. Allan. 1999. Dynamic association of cytoplasmic dynein heavy chain 1a with the Golgi apparatus and intermediate compartment. J Cell Sci. 112 ( Pt 24):4673-4685. Sahlender, D.A., R.C. Roberts, S.D. Arden...

  17. Completion Report for Well ER-20-4 Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    SciTech Connect (OSTI)

    NSTec Environmental Management

    2011-04-30T23:59:59.000Z

    Well ER-20-4 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada National Security Site, Nye County, Nevada. The well was drilled in August and September 2010 as part of the Pahute Mesa Phase II drilling program. The primary purpose of the well was to investigate the possibility of radionuclide transport from up-gradient underground nuclear tests conducted in central Pahute Mesa. This well also provided detailed hydrogeologic information in the Tertiary volcanic section that will help reduce uncertainties within the Pahute Mesa-Oasis Valley hydrostratigraphic framework model.

  18. Identification of the {gamma}-vibrational band built on the 11/2{sup -}[505] orbital in {sup 165}Er

    SciTech Connect (OSTI)

    Wang, S. T. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Graduate University of Chinese Academy of Sciences, Beijing 100049 (China); Zhou, X. H.; Zhang, Y. H.; Sun, Z. Y.; Zheng, Y.; Liu, M. L.; Chen, L.; Zhang, N. T.; Hu, J.; Ma, F.; Hua, W.; Guo, S.; Qiang, Y. H.; Ma, L.; Fang, Y. D.; Li, G. S.; Zhou, H. B.; Ding, B.; Wang, H. X.; Lei, X. G. [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China)

    2011-09-15T23:59:59.000Z

    Excited states in {sup 165}Er have been populated using the {sup 160}Gd({sup 9}Be, 4n) reaction at beam energies of 42 and 45 MeV. A band consisting of two levels at excitation energies of 1317.6 and 1505.9 keV, both of which decay strongly to the 11/2{sup -}[505] band, is observed and assigned as the {gamma}-vibrational band built on the 11/2{sup -}[505] configuration. In addition, a newly identified level is proposed as a three-quasiparticle state.

  19. Final Technical Report DOE Award DE-FG02-07ER41515 QUEST Camera Short Term Maintenance

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinan antagonist Journal Article: Crystal structureComposite--FOR IMMEDIATEDOE Award DE-FG02-07ER41515 QUEST

  20. ER2 Instrumentation and Measurements for CLASIC (Cloud Land Surface Interaction Campaign) June-2007 SGP {Author-Jimmy Voyles}

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed NewcatalystNeutronEnvironment >Dange1·DangerEPADetection R. De Souza 1 ,ER2

  1. TRACTOGRAPHY OF FORNIX, CINGULUM, AND CORPUS CALLOSUM IN RAT BRAIN

    E-Print Network [OSTI]

    was performed and visually inspected for anatomical correctness according to a rat atlas brain. Values of Trace as the effects of pharmacological drugs on white matter. DISCUSSION Figure 4: Trace, FA, RD, and AD Figure 1: Rat

  2. Discrimination between energy transfer and back transfer processes for GaAs host and Er luminescent dopants using electric response analysis

    SciTech Connect (OSTI)

    Ishii, Masashi, E-mail: ISHII.Masashi@nims.go.jp [National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0047 (Japan); Koizumi, Atsushi; Fujiwara, Yasufumi [Division of Materials and Manufacturing Science, Graduate School of Engineering Osaka University, Suita, Osaka 565-0871 (Japan); Takeda, Yoshikazu [Nagoya Industrial Science Research Institute, Nagoya, Aichi 464-0819 (Japan)

    2014-04-07T23:59:59.000Z

    The energy transfer and back transfer processes of GaAs co-doped with Er and O (GaAs:Er,O) were experimentally distinguished by using a frequency response analysis of the AC photocurrent. The results were achieved by using the difference in the frequency dispersion between (1) the dispersion of the energy transfer, which is triggered by the trapping of free charges in the GaAs host and is represented with the Debye relaxation response and (2) the dispersion of the energy back transfer, which is induced by non-radiative transition of 4f bound electrons in the Er dopants and is described with a Lorentzian. The Debye relaxation response found in GaAs:Er,O provided a charge trapping time that was dependent on temperature, which was well correlated with the thermal quenching property of intense intra-4f-shell luminescence. The spectral shape of the Lorentzian dependence on the temperature was explained with the thermal excitation of Er 4f electrons and release of trapped charges in GaAs. The thermal excitation and release of charges consistently explained the characteristics of weak 4f luminescence in low- and high-temperature regions, respectively.

  3. Luminescence thermometry below room temperature via up-conversion emission of Y{sub 2}O{sub 3}:Yb{sup 3+},Er{sup 3+} nanophosphors

    SciTech Connect (OSTI)

    Lojpur, V.; Nikoli?, G.; Drami?anin, M. D., E-mail: dramican@vinca.rs [Vin?a Institute of Nuclear Sciences, University of Belgrade, P.O. Box 522, Belgrade 11001 (Serbia)

    2014-05-28T23:59:59.000Z

    This study explores potential of Er{sup 3+}-Yb{sup 3+} doped phosphors for up-conversion luminescence thermometry in the temperature range from 10?K to 300?K. Yttrium oxide nanopowder doped with trivalent ytterbium and erbium ions (Y{sub 1.97}Yb{sub 0.02}Er{sub 0.01}O{sub 3}) was prepared by hydrothermal synthesis as an example. The intensity ratios of up-conversion emissions from thermally coupled {sup 2}H{sub 11/2} and {sup 4}S{sub 3/2} levels of Er{sup 3+} show strong temperature dependence (in the range 150?K300?K) with much higher relative sensitivity than those reported for thermometry above room temperature with Er{sup 3+}-Yb{sup 3+} based up-conversion materials. The maximal value of relative sensitivity is 5.28%K{sup ?1} at 150?K, with temperature resolution ranging from 0.81?K to 0.06?K. In addition, the intensity ratios of emission from thermally non-coupled Er{sup 3+} levels ({sup 2}H{sub 9/2} and {sup 4}F{sub 9/2}) and from {sup 4}S{sub 3/2} also show temperature dependence that can be approximated with an exponential function. With these up-conversion emission ratios, it is possible measure temperature in the range of 10?K to 300?K with excellent sensitivity and resolution.

  4. Optical properties and energy transfer processes of Ho{sup 3+}/Er{sup 3+}- codoped fluorotellurite glass under 1550?nm excitation for 2.0??m applications

    SciTech Connect (OSTI)

    Huang, Feifei; Liu, Xueqiang [Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China); Graduate School of Chinese Academy of Sciences, Beijing 100039 (China); Hu, Lili; Chen, Danping, E-mail: dpchen2008@aliyun.com [Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China)

    2014-07-21T23:59:59.000Z

    This paper investigates 2.0??m emission properties and energy transfer processes in the Er{sup 3+}/Ho{sup 3+} codoped fluorotellurite glass. The measured absorption spectra demonstrate that the codoped sample can be pumped by 1550?nm excitation efficiently. Judd-Ofelt and radiative parameters are calculated and discussed. Intensive 2.0??m emission originating from Ho{sup 3+}: {sup 5}I{sub 7}?{sup 5}I{sub 8} transition is observed and a long lifetime (11?ms) of the {sup 5}I{sub 7} level is measured when Ho{sup 3+} ions are sensitized by Er{sup 3+} ions. Meanwhile, the upconversion spectra of the Er{sup 3+} singly and codoped samples are obtained and the energy transfer processes of the two ions is discussed based on the change of the upconversion emissions. The microscopic interaction parameters of the phonon-assisted (Er{sup 3+}: {sup 4}I{sub 13/2}?Ho{sup 3+}:{sup 5}I{sub 7}) process are calculated and the microparameter reaches as high as 10.1??10{sup ?41} cm{sup 6}/s. Hence, these results indicate that this Ho{sup 3+}/Er{sup 3+} codoped fluorotellurite glass will be a suitable material for developing solid state laser around 2.0??m.

  5. FInal Report: DE-FG02-04ER41310 "Elementary Particle Physics"

    SciTech Connect (OSTI)

    Izen, Joseph M. [University of Texas at Dallas] [University of Texas at Dallas; Ishak-Boushaki, Mustapha [University of Texas at Dallas] [University of Texas at Dallas

    2013-10-18T23:59:59.000Z

    ATLAS and the LHC are delivering on the promise of discovery physics at the high energy frontier. Using 4.8 fb^-1 of 2011 ?s=7 TeV data and the first 5.8 fb?1 of 2012 ?s=8 TeV data, ATLAS published the observation of a new particle with a mass of 126 GeV with a significance of 5.9? that is compatible with a Standard Model (SM) Higgs. The LHC is outperforming intial projections for the 2012 run, and ATLAS is on track to integrate ~20 fb^(-1) of proton-proton collisions in 2012 before Long Shutdown 1 (LS1) begins in Spring 2013. University of Texas at Dallas (UTD) physicists will complete work on two ATLAS analyses this fall. The first is the search for the gauge bosons of a hypothesized dark sector. For 2011 data, UTD is responsible for the ?dark photon?search in the electron-jet channel, and we are looking forward to an expanded leadership role in the dark photon search using the full 2012 data set. Our second analysis interest is the study of X/Y/Z exotic states having cc ? content, which builds on our experience in this field from the BABAR experiment After completing a measurement of the Xc(3872) production cross section this fall, we will search for evidence of the Z(4430)+ which is reported by Belle but not confirmed by BABAR. The UTD group has played a strong role in ATLAS operations, with group members serving as Pixel Run Coordinator, ATLAS Shift Leader, and Pixel/Inner Detector Shifter. For most of the current 3-year funding cycle, a group member coordinated the development of the Pixel DAQ code, and another continues to build and maintain the data quality monitoring (DQM) application that is used by the Inner Detector control room shifter. Additionally, members of our group take Pixel on-call expert shifts for DQM and DAQ. We led an optoboard lifetime study to assess concerns of premature on-detector VCSEL failure using the Pixel working prototype detector at CERN. Physicists based at UTD participated through Pixel Offline DQM and ATLAS Distributed Computing Operations Shifts (ADCoS) During Summer 2012, UTD joined upgrade activities in preparation for LS1. We took a major role in the testing of Electro-Readout (ER) Bundle testing for new Service Quarter Panels (nSQP?s), and we developed two utilities to measure the timing jitter and bit error rate of the Pixel readout chain for use commissioning Pixel detector upgrades. During BABAR?s heyday, the UTD group pioneered the use of e^+ e^- annihilation events with hard Initial State Radiation (ISR) to study the charm threshold region, and we carried out the first BABAR double-cc ? analysis. Our most recent ISR paper, written in collaboration with A. Palano (Bari) is Exclusive Production of Ds^+ Ds^-, D_S^(*+) Ds^-, and Ds^(*+) Ds^(*-) via e+ e- Annihilation with Initial-State-Radiation was published in Physical Review D 82, 052004 (2010). Work continues on a study of ISR ?c^+ ?c^- production, and a new search to establish and study double-ss ? production is starting.

  6. The influence of magnesium deficiency on inflammatory reaction in rats

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    The influence of magnesium deficiency on inflammatory reaction in rats Régine DELAIGUE, P. DUCHENE, France. Summary. The inflammatory reactions obtained in magnesium-deficient rats, by injecting of inflammatory reactions observed in magnesium- deficient rats could not be explained only by histamine

  7. Completion Report for Well ER-EC-14, Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    SciTech Connect (OSTI)

    None

    2013-03-05T23:59:59.000Z

    Well ER-EC-14 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Management Operations Underground Test Area (UGTA) Activity at the Nevada National Security Site (NNSS; formerly Nevada Test Site), Nye County, Nevada. The well was drilled in September and October 2012, as part of the Central and Western Pahute Mesa Corrective Action Unit Phase II drilling program. The primary purpose of the well was to provide detailed hydrogeologic information for the Fortymile Canyon composite hydrostratigraphic unit in the Timber Mountain moat area, within the Timber Mountain caldera complex, that will help address uncertainties within the Pahute MesaOasis Valley hydrostratigraphic framework model. The main 55.9-centimeter (cm) hole was drilled to a total depth of 325.5 meters (m) and cased with 40.6-cm casing to 308.1 m. The hole diameter was then decreased to 37.5 cm, and drilling continued to a total depth of 724.8 m. The completion casing string, set to the depth of 690.9 m, consists of 16.8-cm stainless-steel casing hanging from 19.4-cm carbon-steel casing. The stainless-steel casing has two slotted intervals open to the Rainier Mesa Tuff. Two piezometer strings were installed in Well ER-EC-14. Both piezometer strings, each with one slotted interval, consist of 6.0-cm carbon-steel tubing at the surface, then cross over to 7.3-cm stainless-steel tubing just above the water table. The shallow piezometer string was landed at 507.8 m, and the deep piezometer string was landed at 688.6 m. Both piezometer strings are set to monitor groundwater within moderately to densely welded Rainier Mesa Tuff. Data collected during and shortly after hole construction include composite drill cuttings samples collected every 3.0 m, various geophysical logs, water quality (including tritium and other radionuclides) measurements, and water level measurements. The well penetrated 15.2 m of alluvium and 709.6 m of Tertiary volcanic rocks. The stratigraphy and general lithology were not as expected due to the position of Well ER-EC-14 relative to the buried caldera margins of the Timber Mountain caldera complex. The well is located inside the Rainier Mesa caldera, but outside the younger Ammonia Tanks caldera. On November 5, 2012, a preliminary fluid level in the shallow piezometer string was measured at the depth of 311.8 m. This water level depth was taken before installation of the bridge plug (to be placed within the main completion casing to separate the two slotted zones). Well development, hydrologic testing, and sampling, will be conducted at a later date. No tritium above levels detectable by field methods were encountered in this hole. All Fluid Management Plan (FMP) requirements for Well ER-EC-14 were met. Analysis of monitoring samples and FMP confirmatory samples indicated that fluids generated during drilling at Well ER-EC-14 met the FMP criteria for discharge to an unlined sump or designated infiltration area. All sanitary and hydrocarbon waste generated was properly handled and disposed of.

  8. In-situ time-of-flight neutron diffraction of ErD2 (beta phase) formation during D2 loading.

    SciTech Connect (OSTI)

    Browning, James Frederick (Oak Ridge National Laboratory, Oak Ridge, TN); Llobet, Anna (Los Alamos National Laboratory, Los Alamos, NM); Snow, Clark Sheldon; Rodriguez, Mark Andrew; Wixom, Ryan R.

    2008-06-01T23:59:59.000Z

    In an effort to better understand the structural changes occurring during hydrogen loading of erbium target materials, we have performed D{sub 2} loading of erbium metal (powder) with simultaneous neutron diffraction analysis. This experiment tracked the conversion of Er metal to the {alpha} erbium deuteride (solid-solution) phase and then on to the {beta} (fluorite) phase. Complete conversion to ErD{sub 2.0} was accomplished at 10 Torr D{sub 2} pressure with deuterium fully occupying the tetrahedral sites in the fluorite lattice. Increased D{sub 2} pressure (up to 500 Torr at 450 C) revealed {approx}10 % deuterium occupation of the octahedral sites. Subsequent vacuum pumping of the sample at 450 C removed octahedral site occupancy while maintaining tetrahedral deuterium occupancy, thereby yielding stoichiometric ErD{sub 2.0} {beta} phase.

  9. Viability of adult rat skin following 13 Mev proton irradiation

    E-Print Network [OSTI]

    Caraway, Bobby Lamar

    1966-01-01T23:59:59.000Z

    then removed from suspension by centrifugation and washed twice in Smith's chick heart growth media. 33 All cells removed from the biopsy by this enzyme dissection were placed in culture to check viability. Two Rose chambers con- taining the first scraping... Dissipation . Diagram ? Proton Energy Dissipation 17 17 Cell Suspension Filter Tube. Exploded View of Rose Chamber 24 Rat 822, Gross Appearance 37 SB. Rat 822, Skin Section. 38 Rat 771, Gross Appearance 37 Rat 771, Skin Section. 38 7A. 7B. Rat 835...

  10. DE-FG02-08ER64658 (OASIS) - Final Technical Report

    SciTech Connect (OSTI)

    Sharman, Jonathan

    2013-09-05T23:59:59.000Z

    Project OASIS (Operation of Advanced Structures, Interfaces and Sub-components for MEAs) was a 12 month project that ran from 1st September 2008 to 31st August 2009, and was managed by the Department of Energy Office of Science, Chicago Office, as Award No DE-FG02-08ER64658, with Johnson Matthey Fuel Cells Inc. as the sole contractor. The project was completed on schedule, with technical successes (details below) and payment of the full grant award made by DOE. The aim of the project was the development of membrane electrode assemblies (MEAs) for H2/air polymer electrolyte membrane (PEM) fuel cells that would give higher performance under hot/dry and dry operating conditions, ideally with no loss of performance under wet conditions. Reducing or eliminating the need for humidifying the incoming gases will allow significant system cost and size reduction for many fuel cell applications including automotive, stationary and back-up power, and portable systems. Portable systems are also of particular interest in military markets. In previous work Johnson Matthey Fuel Cells had developed very stable, corrosion-resistant catalysts suitable for resisting degradation by carbon corrosion in particular. These materials were applied within the OASIS project as they are considered necessary for systems such as automotive where multiple start-stop events are experienced. These catalysts were contrasted with more conventional materials in the design of catalyst layers and novel microporous layers (MPLs) and gas diffusion layer (GDL) combinations were also explored. Early on in the work it was shown how much more aggressive high temperature operation is than dry operation. At the same humidity, tests at 110?C caused much more dehydration than tests at 80?C and the high temperature condition was much more revealing of improvements made to MEA design. Alloy catalysts were introduced and compared with Pt catalysts with a range of particle sizes. It was apparent that the larger particle sizes of the alloy catalysts led to a reduction in performance that offset much of their kinetic advantage. The Pt-only materials clearly showed that small particles are beneficial to good performance under hot/dry conditions, because of their higher surface area, although they are known to be less stable to cyclic operation. An ex-situ water vapour sorption technique was developed that showed a very clear correlation with in-cell performance: catalyst powders that absorbed more water gave better performance in-cell. It was shown that alloy catalysts could give a 25 mV advantage over Pt-only at 1 Acm-2. GDL design was also shown to influence performance and more permeable GDLs on the anode allowed better membrane hydration and therefore conductivity. A very impermeable GDL on the cathode caused cathode flooding even under dry conditions, but a novel cathode MPL incorporating ionomer and operating at 110?C, 33/17% RH showed a 150 mV gain at 800 mAcm-2 over the conventional MPL. This project has increased the understanding of the factors that influence performance loss under dry conditions, including the development of an insightful ex-situ characterisation technique (Dynamic Vapour Sorption). All the approaches investigated can be readily implemented in state-of the-art MEAs, although optimisation would be needed to integrate the new designs with existing MEA types and to tune to the exact range of operating conditions. The work is thus expected to benefit the public by feeding through more condition-tolerant production MEAs to a range of applications and thereby accelerate the commercialisation of fuel cell technology. In summary, a number of specific catalyst, catalyst layer, MPL and GDL improvements were made during this project. Often the best designs under dry conditions translated to some performance loss under wet conditions, but compromise situations were also found where dry performance was improved with no loss of wet performance.

  11. Completion Report for Well ER-EC-13 Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    SciTech Connect (OSTI)

    NSTec Environmental Management

    2011-05-31T23:59:59.000Z

    Well ER-EC-13 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, in support of the Nevada Environmental Restoration Project at the Nevada National Security Site (formerly Nevada Test Site), Nye County, Nevada. The well was drilled in October 2010 as part of the Pahute Mesa Phase II drilling program. A main objective was to provide detailed hydrogeologic information for the Fortymile Canyon composite unit hydrostratigraphic unit in the Timber Mountain moat area, within the Timber Mountain caldera complex, that will help address uncertainties within the Pahute MesaOasis Valley hydrostratigraphic framework model. This well may also be used as a long-term monitoring well.

  12. Well Completion Report for Well ER-20-11, Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    SciTech Connect (OSTI)

    NSTec Environmental Management

    2013-02-27T23:59:59.000Z

    Well ER-20-11 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Management Operations Underground Test Area (UGTA) Activity at the Nevada National Security Site (formerly Nevada Test Site), Nye County, Nevada. The well was drilled in September 2012 as part of the Central and Western Pahute Mesa Corrective Action Unit Phase II drilling program. Well ER-20-11 was constructed to further investigate the nature and extent of radionuclidecontaminated groundwater encountered in two nearby UGTA wells, to help define hydraulic and transport parameters for the contaminated Benham aquifer, and to provide data for the UGTA hydrostratigraphic framework model. The 44.5-centimeter (cm) surface hole was drilled to a depth of 520.0 meters (m) and cased with 34.0-cm casing to 511.5 m. The hole diameter was then decreased to 31.1 cm, and the borehole was drilled to a total depth of 915.6 m. The hole was completed to allow access for hydrologic testing and sampling in the target aquifer, which is a lava-flow aquifer known as the Benham aquifer. The completion casing string, set to the depth of 904.3 m, consists of a string of 6?-inch (in.) stainless-steel casing hanging from a string of 7?-in. carbon-steel casing. The stainless-steel casing has one slotted interval at 796.3 to 903.6 m. One piezometer string was installed, which consists of 2?-in. stainless-steel tubing that hangs from 2?-in. carbon-steel tubing via a crossover sub. This string was landed at 903.8 m and is slotted in the interval 795.3 to 903.1 m. Data collected during and shortly after hole construction include composite drill cuttings samples collected every 3.0 m, various geophysical logs, fluid samples (for groundwater chemistry analysis and tritium measurements), and water-level measurements. The well penetrated 915.6 m of Tertiary volcanic rock, including one saturated lava flow aquifer. Measurements on samples taken from the undeveloped well indicated elevated tritium levels within the Benham aquifer. The maximum tritium level measured with field equipment was 146,131 picocuries per liter from a sample obtained at the depth of 912.0 m. The fluid level was measured in the piezometer string at a depth of 504.5 m on September 26, 2012. All Fluid Management Plan (FMP) requirements for Well ER-20-11 were met. Analysis of monitoring samples and FMP confirmatory samples indicated that fluids generated during drilling at Well ER-20-11 met the FMP criteria for discharge to an unlined sump or designated infiltration area. Well development, hydrologic testing, and sampling will be conducted at a later date.

  13. Completion Report for Well ER-EC-15 Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    SciTech Connect (OSTI)

    NSTec Environmental Management

    2011-05-31T23:59:59.000Z

    Well ER-EC-15 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada National Security Site (formerly known as the Nevada Test Site), Nye County, Nevada. The well was drilled in October and November 2010, as part of the Pahute Mesa Phase II drilling program. The primary purpose of the well was to provide detailed hydrogeologic information in the Tertiary volcanic section in the area between Pahute Mesa and the Timber Mountain caldera complex that will help address uncertainties within the Pahute MesaOasis Valley hydrostratigraphic model. In particular, the well was intended to help define the structural position and hydraulic parameters of volcanic aquifers potentially down-gradient from underground nuclear tests on Pahute Mesa. It may also be used as a long-term monitoring well.

  14. Completion Report for Well ER-EC-12 Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    SciTech Connect (OSTI)

    NSTec Environmental Management

    2011-04-30T23:59:59.000Z

    Well ER-EC-12 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada National Security Site (formerly known as the Nevada Test Site), Nye County, Nevada. The well was drilled in June and July 2010 as part of the Pahute Mesa Phase II drilling program. The primary purpose of the well was to provide detailed hydrogeologic information in the Tertiary volcanic section in the area between Pahute Mesa and the Timber Mountain caldera complex that will help address uncertainties within the Pahute MesaOasis Valley hydrostratigraphic model. In particular, the well was intended to help define the structural position and hydraulic parameters for volcanic aquifers potentially down-gradient from historic underground nuclear tests on Pahute Mesa. It may also be used as a long-term monitoring well.

  15. Relativistic energy density functionals: Low-energy collective states of {sup 240}Pu and {sup 166}Er

    SciTech Connect (OSTI)

    Li, Z. P. [Physics Department, Faculty of Science, University of Zagreb, 10000 Zagreb (Croatia); State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing 100871 (China); School of Physical Science and Technology, Southwest University, Chongqing 400715 (China); Niksic, T.; Vretenar, D. [Physics Department, Faculty of Science, University of Zagreb, 10000 Zagreb (Croatia); Ring, P. [State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing 100871 (China); Physik-Department der Technischen Universitaet Muenchen, D-85748 Garching (Germany); Meng, J. [State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing 100871 (China); School of Physics and Nuclear Energy Engineering, Beihang University, Beijing 100191 (China)

    2010-06-15T23:59:59.000Z

    The empirical relativistic density-dependent, point-coupling energy density functional, adjusted exclusively to experimental binding energies of a large set of deformed nuclei with Aapprox =150-180 and Aapprox =230-250, is tested with spectroscopic data for {sup 166}Er and {sup 240}Pu. Starting from constrained self-consistent triaxial relativistic Hartree-Bogoliubov calculations of binding energy maps as functions of the quadrupole deformation in the beta-gamma plane, excitation spectra and E2 transition probabilities are calculated as solutions of the corresponding microscopic collective Hamiltonian in five dimensions for quadrupole vibrational and rotational degrees of freedom and compared with available data on low-energy collective states.

  16. Role of silicon excess in Er-doped silicon-rich nitride light emitting devices at 1.54??m

    SciTech Connect (OSTI)

    Ramrez, J. M., E-mail: jmramirez@el.ub.edu; Berencn, Y.; Garrido, B. [MIND-IN2UB, Department Electrnica, Universitat de Barcelona, Mart i Franqus 1, Barcelona 08028 (Spain); Cueff, S. [Institut des Nanotechnologies de Lyon, cole Centrale de Lyon, cully 69134 (France); Labb, C. [Centre de Recherche sur les Ions, les Matriaux et la Photonique (CIMAP), UMR 6252 CNRS/CEA/Ensicaen/UCBN, Caen 14050 (France)

    2014-08-28T23:59:59.000Z

    Erbium-doped silicon-rich nitride electroluminescent thin-films emitting at 1.54??m have been fabricated and integrated within a metal-oxide-semiconductor structure. By gradually varying the stoichiometry of the silicon nitride, we uncover the role of silicon excess on the optoelectronic properties of devices. While the electrical transport is mainly enabled in all cases by Poole-Frenkel conduction, power efficiency and conductivity are strongly altered by the silicon excess content. Specifically, the increase in silicon excess remarkably enhances the conductivity and decreases the charge trapping; however, it also reduces the power efficiency. The main excitation mechanism of Er{sup 3+} ions embedded in silicon-rich nitrides is discussed. The optimum Si excess that balances power efficiency, conductivity, and charge trapping density is found to be close to 16%.

  17. Single and two-photon fluorescence control of Er{sup 3+} ions by phase-shaped femtosecond laser pulse

    SciTech Connect (OSTI)

    Zhang, Shian, E-mail: sazhang@phy.ecnu.edu.cn; Ding, Jingxin; Lu, Chenhui; Jia, Tianqing; Sun, Zhenrong, E-mail: zrsun@phy.ecnu.edu.cn [State Key Laboratory of Precision Spectroscopy, and Department of Physics, East China Normal University, Shanghai 200062 (China)] [State Key Laboratory of Precision Spectroscopy, and Department of Physics, East China Normal University, Shanghai 200062 (China); Xu, Shuwu [State Key Laboratory of Precision Spectroscopy, and Department of Physics, East China Normal University, Shanghai 200062 (China) [State Key Laboratory of Precision Spectroscopy, and Department of Physics, East China Normal University, Shanghai 200062 (China); School of Science, Nantong University, Nantong 226007 (China); Qiu, Jianrong [State Key Laboratory of Luminescent Materials and Devices, and Institute of Optical Communication Materials, South China University of Technology, Wushan Road 381, Guangzhou 510640 (China)] [State Key Laboratory of Luminescent Materials and Devices, and Institute of Optical Communication Materials, South China University of Technology, Wushan Road 381, Guangzhou 510640 (China)

    2014-01-06T23:59:59.000Z

    We experimentally demonstrate the control of the single and two-photon fluorescence (SPF and TPF) in Er{sup 3+} ions by shaping the femtosecond laser pulse with a ? or square phase modulation. With the low laser intensity (8.4??10{sup 10}?W/cm{sup 2}), SPF keeps a constant while TPF is effectively suppressed by the two control schemes. With the high laser intensity (1.2??10{sup 13}?W/cm{sup 2}), both SPF and TPF are simultaneously enhanced or suppressed by the ? phase modulation, and SPF is enhanced while TPF is effectively suppressed by the square phase modulation. The up/down-conversion fluorescence enhancement, suppression, or tuning by the optical control method can greatly expand its applications in various related fields.

  18. ErAs:,,InGaAs...1-x,,InAlAs...x alloy power generator modules Gehong Zeng,a

    E-Print Network [OSTI]

    Bowers, John

    p-type ErAs:InGaAs alloy thermoelectric elements. The thermoelectric properties of the materials power and efficiency of a thermoelectric generator module depend largely on the material. Thermoelectric properties can be improved by introducing nanometer scale structure into materials.2 In this way

  19. Final Report for Grant DE-FG02-91ER40690 for the period 12/1/2010 to 4/30/2014

    SciTech Connect (OSTI)

    Kass, R.; Durkin, L.; Hill, C.; Braaten, E.; Mathur, S.; Raby, S.; Shigemitsu, J.; Gan, K.; Kagan, H.; Hughes, R.; Winer, B.; Honscheid, K.

    2014-07-22T23:59:59.000Z

    This is the #12;final report for The Ohio State University high energy physics grant DE-FG02- 91ER40690. The activities of the various Tasks are briefy summarized over the previous grant period. The support from the Department of Energy is greatly appreciated.

  20. FLGESKJEMA FOR SKERE TIL PPU TEACH FIRST NORWAY Dersom du har utdanning som ikke er tatt ved UiO, m du skrive ut dette skjemaet og

    E-Print Network [OSTI]

    Løw, Erik

    F?LGESKJEMA FOR S?KERE TIL PPU TEACH FIRST NORWAY Dersom du har utdanning som ikke er tatt ved Ui søke PPU Teach First Norway i Søknadsweb. Ditt navn: Fødselsnr: Jeg har søkt om fagdidaktikk i

  1. Ion irradiation damage in k-doped silica probed by the Er3+ luminescence lifetime at 1.535 pm4

    E-Print Network [OSTI]

    Polman, Albert

    irradiation.' Furthermore, silica-basedop- tical fibers are the standard in telecommunicationtechnol- ogy the effectof MeV ion irradiation damage on the optical propertiesof Er-doped silica films is studied. Erbium-doped silica glasshas recently attracted attention becauseof its use in optical fiber amplifiers.5'6Erbium

  2. The Lujan Center is a national user facility funded by Basic Energy Sciences of the Department of Energy which o ers capability for basic and applied neutron scattering

    E-Print Network [OSTI]

    of Energy which o ers capability for basic and applied neutron scattering relevant to national security are the domain of the low-Q scattering intrument, LQD. These well-established neutron techniques probe long Matter, Local Structure, and Nanomaterials The Lujan Neutron Scattering Center encompasses a set

  3. Optical doping of vwaveguide materials by MeV Er implantation A. Polman,a) D. C. Jacobson, D. J. Eaglesham, Ft. C. Kistler, and J. M. Poate

    E-Print Network [OSTI]

    Polman, Albert

    ions into micron-thick silica and phosphosilicate glass films and 1200-A-thick S&N4 films is studied materials in this planar technology are silica, phosphosilicate glass, and silicon nitride. The silica- based glasses, depending on annealing treatment and Er concentration. Silicon nitride films show lower

  4. 12me Colloque National AIP PRIMECA Le Mont Dore -29 Mars-1er avril 2011 DE SYSML A MODELICA : AIDE A LA FORMALISATION DE

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    12me Colloque National AIP PRIMECA Le Mont Dore - 29 Mars- 1er avril 2011 1 DE SYSML A MODELICA lequel l'approche de l'ingnierie systme base sur les modles est utilise. SysML et Modelica sont les graphique et visuelle alors que Modelica est un langage textuel destin la simulation des modles. Dans le

  5. Butz, T. and von Stryk, O.: Modelling and Simulation of ER and MR Fluid Dampers 1 ZAMM Z. angew. Math. Mech. 78 (1998) 0, 122

    E-Print Network [OSTI]

    Stryk, Oskar von

    Butz, T. and von Stryk, O.: Modelling and Simulation of ER and MR Fluid Dampers 1 ZAMM · Z. angew. Math. Mech. 78 (1998) 0, 1­22 Butz, T.; von Stryk, O. Modelling and Simulation of Electro, phenomenological models, numerical simulation, pas- sive suspension MSC (1991): 65C20, 76A05 1 Introduction Electro

  6. Guided wave absorption and uorescence in epitaxial Er:BaTiO3 on MgO D.M. Gilla,*, G.M. Fordb

    E-Print Network [OSTI]

    Ho, Seng-Tiong

    . Keywords: Er:BaTiO3; Fluorescence; Luminescence 1. Introduction The development of low-cost composite waveguides fabricated in erbium-doped thin-®lm epitaxial BaTiO3. Luminescence transient measurements indicate strategies toward the realization of this type of opto-electronic circuit. Proposed designs of hybrid opto

  7. Social Influences on Food Choices of Norway Rats and Mate Choices of Japanese Quail

    E-Print Network [OSTI]

    Galef, Jr., Bennett G.

    2001-01-01T23:59:59.000Z

    ecology and sociology of the Norway rat . Bethesda: U.S. De-food stealing by young Norway rats. Journal of Comparativesufficient diet by Norway rats. Journal of Comparative

  8. Demography of auklets Aethia spp. in relation to introduced Norway rats Rattus norvegicus at Kiska

    E-Print Network [OSTI]

    Jones, Ian L.

    Demography of auklets Aethia spp. in relation to introduced Norway rats Rattus norvegicus at Kiska................................................................................................4 Norway Rat Abundance and Distribution .........................................................5................................................................................................6 Norway Rat Abundance and Distribution.........................................................7

  9. Dose Dependent Response to Cyclodextrin Infusion in a Rat Model of Verapamil Toxicity

    E-Print Network [OSTI]

    Mottram, Allan R.; Bryant, Sean M; Aks, Steven E

    2012-01-01T23:59:59.000Z

    Effect of cyclodextrin infusion in a rat model of verapamilresuscitation with a lipid infusion shifts the dose-responseResponse to Cyclodextrin Infusion in a Rat Model of

  10. E-Print Network 3.0 - adult rats effects Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in Norway rats and von Frisch's (1967) extraordinary demonstrations of social effects on food selection... observed that Norway rats born to a colony whose adults had learned to...

  11. E-Print Network 3.0 - adult rat brain Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Image Analysis... Cytochem 44:981-987,19%) KEY WORDS: Immunohistochemistry; Image analysis; GABAAre- ceptor; Rat; Brain... density in postfixed thin sections of rat...

  12. Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Nicotine in Rat Brain Tissue by Use of Nanospray Desorption Electrospray Ionization Mass Spectrometry. Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption...

  13. E-Print Network 3.0 - adult rat liver Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    from normal rat liver and incubated for 3 or 16 hours with increasing doses... of carbon tetrachloride (CCl4). Rat ... Source: Groningen, Rijksuniversiteit - Centre for...

  14. Suppressed serum prolactin in sinoaortic-denervated rats

    SciTech Connect (OSTI)

    Alexander, N.; Melmed, S.; Morris, M.

    1987-02-01T23:59:59.000Z

    The authors investigated the effect of arterial baroreceptor deafferentation on serum and pituitary prolactin (PRL) and on catecholamines in median eminence (ME) and anterior and posterior pituitaries. Male Wistar rats were sinoaortic denervated (SAD) or sham operated (SO). Three days after surgery serum prolactin, measured by radioimmunoassay, was suppressed in SAD rats, and dopamine (DA) and norepinephrine (NE) concentrations, measured by radioenzymatic or high-performance liquid chromatography electron capture methods, were significantly reduced in ME of SAD rats. Simultaneously, anterior pituitary of SAD rats had significant increases in both catecholamines, whereas posterior pituitary showed no changes. Four hours after surgery serum PRL was also reduced in SAD rats, but no changes in ME catecholamines were found. Mean arterial pressure (MAP) and heart rate were measured before and after injection of bromocriptine in SAD and SO rats 3 days after surgery. Bromocriptine markedly suppressed serum PRL in both groups and reduced MAP from 144 +/- 10 to 84 +/- 5 and from 116 +/- 2 to 99 +/- 3 in SAD and SO rats, respectively; heart rate was reduced in SAD rats. They conclude that the SAD rat is a model of hypertension with suppressed serum PRL and that interruption of arterial baroreceptor nerves suppresses PRL secretion probably by modulating tuberoinfundibular turnover of catecholamines.

  15. adult rat vestibular: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    stimulate cell proliferation in adult rat vestibular sensory epithelia, as does the infusion of transforming growth factor alpha (TGF ) plus insulin. We sought to determine...

  16. Uranium biokinetics in gavaged young adult female rats.

    E-Print Network [OSTI]

    Keizer, Philip John

    1986-01-01T23:59:59.000Z

    ??Blood, liver, kidney, femur, and ovaries were assayed from female Wistar rats following oral administration of uranyl nitrate. Three uranium concentrations were studied for six (more)

  17. Completion Report for Well ER-EC-11 Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    SciTech Connect (OSTI)

    NSTec Environmental Management

    2010-12-01T23:59:59.000Z

    Well ER-EC-11 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, in support of the Nevada Environmental Restoration Project at the Nevada National Security Site (formerly Nevada Test Site), Nye County, Nevada. The well was drilled in September and October 2009 as part of the Pahute Mesa Phase II drilling program. A main objective was to investigate radionuclide migration down-gradient from Well Cluster ER-20-5 and Well ER-20-7 and across the northern Timber Mountain moat structural zone into the area referred to as the Bench, between Pahute Mesa and the Timber Mountain caldera complex. A secondary purpose of the well was to provide detailed hydrogeologic information for the shallow- to intermediate-depth Tertiary volcanic section in the Bench area. This well also provided detailed hydrogeologic information in the Tertiary volcanic section to reduce uncertainties within the Pahute Mesa-Oasis Valley hydrostratigraphic framework model (Bechtel Nevada, 2002). The main 52.1-centimeter hole was drilled to a depth of 507.5 meters and then opened to a diameter of 66.0 centimeters. It was cased with 50.8-centimeter casing to 504.9 meters. The hole diameter was then decreased to 47.0 centimeters, and drilling continued to a total depth of 979.3 meters. It was then cased with 34.0-centimeter casing set at 965.5 meters. The hole diameter was then decreased to 31.1 centimeters and the borehole was drilled to a total depth of 1,264.3 meters. The completion casing string, set to the depth of 1,262.5 meters, consists of 19.4-centimeter stainless-steel casing hanging from 19.4-centimeter carbon-steel casing. The stainless-steel casing has two slotted intervals open to the Tiva Canyon and Topopah Spring aquifers. Four piezometer strings were installed in Well ER-EC-11. A string of carbon-steel 6.0-centimeter tubing with one slotted interval was inserted outside the 50.8-centimeter casing, within the 66.0-centimeter borehole for access to the Timber Mountain aquifer, and landed at 475.3 meters. A second string of 6.0-centimeter tubing with one slotted interval was inserted outside the 34.0-centimeter casing, within the 47.0-centimeter borehole for access to the Benham aquifer, and landed at 911.7 meters. A third piezometer string consists of 7.3-centimeter stainless-steel tubing that hangs from 6.0-centimeter carbon-steel tubing via a crossover sub. This string was landed at 1,029.5 meters to monitor the Tiva Canyon aquifer. The deepest string of 7.3-centimeter tubing was landed at 1,247.8 meters to monitor the Topopah Spring aquifer. Data collected during and shortly after hole construction include composite drill cuttings samples collected every 3.0 meters, 67 percussion gun and rotary sidewall core samples, various geophysical logs, fluid samples (for groundwater chemistry analysis and tritium measurements), and water-level measurements. The well penetrated 1,264.3 meters of Tertiary volcanic rock, including three saturated welded-tuff aquifers and one saturated lava-flow aquifer. A water level was measured in the Timber Mountain aquifer at 449.6 meters, during open-hole geophysical logging on September 20, 2009. The fluid level measured after the total depth was reached and the upper aquifer was cased off was 450.0 meters when measured in the open borehole on October 17, 2009. Measurements on samples taken from the undeveloped well indicated that tritium levels averaging approximately 12,430 picocuries per liter (less than Safe Drinking Water Act levels) were encountered within the Benham aquifer. Tritium was below the minimum detectable activity concentration for samples collected from the Tiva Canyon aquifer and the Topopah Spring aquifer.

  18. Mid-infrared frequency comb spanning an octave based on an Er fiber laser and difference-frequency generation

    E-Print Network [OSTI]

    Fritz Keilmann; Sergiu Amarie

    2012-03-22T23:59:59.000Z

    We describe a coherent mid-infrared continuum source with 700 cm-1 usable bandwidth, readily tuned within 600 - 2500 cm-1 (4 - 17 \\mum) and thus covering much of the infrared "fingerprint" molecular vibration region. It is based on nonlinear frequency conversion in GaSe using a compact commercial 100-fs-pulsed Er fiber laser system providing two amplified near-infrared beams, one of them broadened by a nonlinear optical fiber. The resulting collimated mid-infrared continuum beam of 1 mW quasi-cw power represents a coherent infrared frequency comb with zero carrier-envelope phase, containing about 500,000 modes that are exact multiples of the pulse repetition rate of 40 MHz. The beam's diffraction-limited performance enables long-distance spectroscopic probing as well as maximal focusability for classical and ultraresolving near-field microscopies. Applications are foreseen also in studies of transient chemical phenomena even at ultrafast pump-probe scale, and in high-resolution gas spectroscopy for e.g. breath analysis.

  19. Near infrared and upconversion luminescence behaviour of Er{sup 3+}/Yb{sup 3+} codoped boro-tellurite glasses

    SciTech Connect (OSTI)

    Maheshvaran, K. [Department of Physics, Gandhigram Rural Institute - Deemed University, Gandhigram - 624302, India and Department of Physics, K.S. Rangasamy College of Technology, Trichengode - 637215 (India); Arunkumar, S., E-mail: mari-ram2000@yahoo.com; Vijayakumar, R., E-mail: mari-ram2000@yahoo.com; Marimuthu, K., E-mail: mari-ram2000@yahoo.com [Department of Physics, Gandhigram Rural Institute ? Deemed University, Gandhigram - 624302 (India)

    2014-04-24T23:59:59.000Z

    The broadband NIR and upconversion luminescence behavior in a new series of Er{sup 3+}/Yb{sup 3+} codoped TeO{sub 2}-B{sub 2}O{sub 3}-SrO-BaO-Li{sub 2}O-LiF glasses have been studied exciting at a wavelength of 980 nm using semiconductor laser. A broadband emission is observed from 1450 to 1650 nm with a full width at half maximum (FWHM) around 165 nm in 0.5wt% Yb{sup 3+} ion content E0.5YLTB glass. The radiative parameters such as transition probability (A), stimulated emission cross-section (?{sup E}), experimental and calculated branching ratios (?{sub R}), optical gain width (?{sub p}FWHM) and radiative lifetime (?{sub cal}) have been calculated for the {sup 4}I{sub 13/2}?{sup 4}I{sub 15/2} NIR emission. Upconversion luminescence spectra of the prepared glasses have been studied and the ESA and ET processes have also been discussed and reported.

  20. Low Lying Magnetic and Electric Dipole Strength Distribution in the Even-Even 164-170Er

    SciTech Connect (OSTI)

    Ertugral, F.; Kuliev, A. A. [Sakarya University, Physics Department, Adapazari (Turkey); Guliyev, E. [Institute of Physics, National Academy of Sciences, H.Cavid Avenue 33, Baku (Azerbaijan)

    2007-04-23T23:59:59.000Z

    Quasiparticle random-phase approximation calculations, where rotational and translational invariance are restored selfconsistently by using separable effective forces, are presented for the ground state dipole response in the even-even 164-170Er isotopes. We consider the 1+ vibrations generated by the isovector spin-spin interactions and the isoscalar and isovector quadrupole type separable forces restoring the broken symmetry by a deformed mean field. It has been shown that restoration of the broken rotational and translational symmetry of the Hamiltonian essentially decrease the B(M1) and the B(E1) values of the low lying 1+ and 1- states and increase the collectivization of the scissors mode and the electric dipole mode excitations in the spectroscopic energy region. The resulting M1 and E1 spectrum are compared with available experimental data. The calculated dipole strengths summed in the energy range 1.8-4 MeV are in agreement with the relevant experimental data. In this nuclei theory predicts many more low-lying 1+ and 1- states than experiment.

  1. Thermal conductivity of Er{sup +3}:Y{sub 2}O{sub 3} films grown by atomic layer deposition

    SciTech Connect (OSTI)

    Raeisi Fard, Hafez; Hess, Andrew; Pashayi, Kamyar; Borca-Tasciuc, Theodorian, E-mail: borcat@rpi.edu [Mechanical, Aerospace and Nuclear Engineering Department, Rensselaer Polytechnic Institute, Troy, New York 12180 (United States)] [Mechanical, Aerospace and Nuclear Engineering Department, Rensselaer Polytechnic Institute, Troy, New York 12180 (United States); Becker, Nicholas; Proslier, Thomas; Pellin, Michael [Material Sciences Division, Argonne National Laboratory 9700 S. Cass Avenue, Lemont, Illinois 60439 (United States)] [Material Sciences Division, Argonne National Laboratory 9700 S. Cass Avenue, Lemont, Illinois 60439 (United States)

    2013-11-04T23:59:59.000Z

    Cross-plane thermal conductivity of 800, 458, and 110?nm erbium-doped crystalline yttria (Er{sup +3}:Y{sub 2}O{sub 3}) films deposited via atomic layer deposition was measured using the 3? method at room temperature. Thermal conductivity results show 16-fold increase in thermal conductivity from 0.49?W m{sup ?1}K{sup ?1} to 8?W m{sup ?1}K{sup ?1} upon post deposition annealing, partially due to the suppression of the number of the -OH/H{sub 2}O bonds in the films after annealing. Thermal conductivity of the annealed film was ?70% lower than undoped bulk single crystal yttria. The cumulative interface thermal resistivity of substrate-Er{sup +3}:Y{sub 2}O{sub 3}-metal heater was determined to be ?2.5??10{sup ?8} m{sup 2} K/W.

  2. Temperature of broadband anti-Stokes white emission in LiYbP{sub 4}O{sub 12}: Er nanocrystals

    SciTech Connect (OSTI)

    Marciniak, L., E-mail: l.marciniak@int.pan.wroc.pl; Strek, W.; Hreniak, D. [Institute of Low Temperature and Structure Research, Polish Academy of Sciences, 50-422 Wroc?aw (Poland); Guyot, Y. [Institute Light Matter (ILM), UMR5306 CNRS-University Lyon1, University of Lyon, 69622 Villeurbanne (France)

    2014-10-27T23:59:59.000Z

    The up-conversion emission of LiYb{sub 0.99}Er{sub 0.01}P{sub 4}O{sub 12} nanocrystals was investigated in vacuum upon the focused beam of infrared laser excitation. The intense white broad band emission was observed above the threshold power of 800 mW. An increase of excitation power results in enhancement of temperature of emitting nanocrystals. The temperature of nanocrystals was determined following the thermally equilibrated f-f emission transitions of Er{sup 3+} ions. The highest measured temperature of white emission was determined to be about 900?K. It is concluded that the black body radiation is not responsible for the white broad band emission.

  3. Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo

    SciTech Connect (OSTI)

    Herrmann, Julia E.; Heale, Jason; Bieraugel, Mike; Ramos, Meg [Drug Safety Evaluation, Allergan Inc., 2525 Dupont Dr, Irvine, CA 92612 (United States); Fisher, Robyn L. [Vitron Inc., Tucson, AZ (United States); Vickers, Alison E.M., E-mail: vickers_alison@allergan.com [Drug Safety Evaluation, Allergan Inc., 2525 Dupont Dr, Irvine, CA 92612 (United States)

    2014-01-15T23:59:59.000Z

    Human response to isoproterenol induced cardiac injury was evaluated by gene and protein pathway changes in human heart slices, and compared to rat heart slices and rat heart in vivo. Isoproterenol (10 and 100 ?M) altered human and rat heart slice markers of oxidative stress (ATP and GSH) at 24 h. In this in vivo rat study (0.5 mg/kg), serum troponin concentrations increased with lesion severity, minimal to mild necrosis at 24 and 48 h. In the rat and the human heart, isoproterenol altered pathways for apoptosis/necrosis, stress/energy, inflammation, and remodeling/fibrosis. The rat and human heart slices were in an apoptotic phase, while the in vivo rat heart exhibited necrosis histologically and further progression of tissue remodeling. In human heart slices genes for several heat shock 70 kD members were altered, indicative of stress to mitigate apoptosis. The stress response included alterations in energy utilization, fatty acid processing, and the up-regulation of inducible nitric oxide synthase, a marker of increased oxidative stress in both species. Inflammation markers linked with remodeling included IL-1?, Il-1?, IL-6 and TNF? in both species. Tissue remodeling changes in both species included increases in the TIMP proteins, inhibitors of matrix degradation, the gene/protein of IL-4 linked with cardiac fibrosis, and the gene Ccl7 a chemokine that induces collagen synthesis, and Reg3b a growth factor for cardiac repair. This study demonstrates that the initial human heart slice response to isoproterenol cardiac injury results in apoptosis, stress/energy status, inflammation and tissue remodeling at concentrations similar to that in rat heart slices. - Highlights: Human response to isoproterenol induced cardiac injury evaluated in heart slices. Isoproterenol altered apoptosis, energy, inflammation and remodeling pathways. Human model verified by comparison to rat heart slices and rat heart in vivo. Human and rat respond to isoproterenol at similar concentrations in vitro.

  4. SUPPLEMENTAL FIGURES Fig. S1. The ER inhibitor ICI 182,780, decreases PR-mediated gene expression in T47D

    E-Print Network [OSTI]

    Hergenrother, Paul J.

    but not OHT inhibits E2-ER-dependent growth of MCF7ERHA cells. MCF7ERHA cells were maintained for 4 days in 6x. S5. TPSF does not down-regulate the level of Muc1. MCF-7 cells were maintained and plated on the levels of AR and GR. The cell lines used and cell growth conditions were those employed in the dose

  5. VOLUME 78, NUMBER 22 P HY S I CA L REV I EW L E T T ER S 2 JUNE 1997 Stability Ordering of Cycle Expansions

    E-Print Network [OSTI]

    Dettmann, Carl

    dysL 1 · · · L k d . (1) The sum is over all distinct nonrepeating combinations of prime cyclesVOLUME 78, NUMBER 22 P HY S I CA L REV I EW L E T T ER S 2 JUNE 1997 Stability Ordering of Cycle, Australia (Received 3 December 1996) We propose that cycle expansions be ordered with respect to stability

  6. Emission intensity in the visible and IR spectral ranges from Si-based structures formed by direct bonding with simultaneous doping with erbium (Er) and europium (Eu)

    SciTech Connect (OSTI)

    Mezdrogina, M. M., E-mail: margaret.m@mail.ioffe.ru; Kostina, L. S.; Beliakova, E. I.; Kuzmin, R. V. [Russian Academy of Sciences, Ioffe Physical-Technical Institute (Russian Federation)] [Russian Academy of Sciences, Ioffe Physical-Technical Institute (Russian Federation)

    2013-09-15T23:59:59.000Z

    The photo- and electroluminescence spectra of silicon-based structures formed by direct bonding with simultaneous doping with rare-earth metals are studied. It is shown that emission in the visible and IR spectral ranges can be obtained from n-Si:Er/p-Si and n-Si:Eu/p-Si structures fabricated by the method suggested in the study. The results obtained make this method promising for the fabrication of optoelectronic devices.

  7. A DELAYED NONLINEAR PBPK MODEL FOR GENISTEIN DOSIMETRY IN RATS

    E-Print Network [OSTI]

    A DELAYED NONLINEAR PBPK MODEL FOR GENISTEIN DOSIMETRY IN RATS #3; MICHAEL G. ZAGER y , HIEN T on laboratory animals and human volunteers [4], and critical literature reviews [32]. Phytoestrogens, a class endocrine-related e#11;ects such as reduced birth weight in rats and humans. In its conjugated form

  8. Energy transfer characteristics of silicate glass doped with Er{sup 3+}, Tm{sup 3+}, and Ho{sup 3+} for ?2 ?m emission

    SciTech Connect (OSTI)

    Li, Ming; Liu, Xueqiang [Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China) [Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China); Graduate School of Chinese Academy of Sciences, Beijing 100039 (China); Guo, Yanyan [College of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022 (China)] [College of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022 (China); Hu, Lili [Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China)] [Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China); Zhang, Junjie [College of Materials Science and Engineering, China Jiliang University, Hangzhou 310 018 (China)] [College of Materials Science and Engineering, China Jiliang University, Hangzhou 310 018 (China)

    2013-12-28T23:59:59.000Z

    A Er{sup 3+}/Tm{sup 3+}/Ho{sup 3+} tri-doped silicate glass with good thermal stability is prepared by melt-quenching method. Efficient ?2 ?m emission is observed under 808 nm laser excitation. It is found that the 2.0 ?m emission of Ho{sup 3+} can be enhanced under the excitation at 808 nm by incorporating Er{sup 3+} and Tm{sup 3+}. Based on the measurement of absorption spectra, the JuddOfelt intensity parameters, radiation emission probability, and branching ratio are calculated to evaluate the spectroscopic properties simultaneously. The maximum value of emission cross section of Ho{sup 3+} is 3.54 10{sup ?21} cm{sup 2} at 2008 nm. Additionally, the phonon assistance and the micro-parameters in the energy transfer process are quantitatively analyzed by using Dexter model. The energy transfer coefficient from Tm{sup 3+} to Ho{sup 3+} can reach as high as 21.44 10{sup ?40} cm{sup 6}/s, respectively. The emission property together with good thermal property indicates that Er{sup 3+}/Tm{sup 3+}/Ho{sup 3+} tri-doped silicate glass is a potential kind of laser glass for efficient 2 ?m laser.

  9. Impacts of the Norway Rat on the auklet breeding colony at Sirius Point, Kiska

    E-Print Network [OSTI]

    Jones, Ian L.

    Impacts of the Norway Rat on the auklet breeding colony at Sirius Point, Kiska Island, Alaska-3239 FAX: (709) 737-3018 e-mail: x19hlm@mun.ca #12;Major and Jones Impacts of the Norway Rat... 2 Fresh rat during World War II (Atkinson, 1985). It is believed that the Norway Rat (Rattus norvegicus

  10. Rat Trachea Dose Distribution Model Using MCNPTM

    E-Print Network [OSTI]

    Almanza, Christian

    2010-01-15T23:59:59.000Z

    formed the trachea. The outer cylinder represented the outer part of the rat trachea with a radius of 0.1 cm, and the other cylinder, with a radius of 0.075 cm, represented the inner part of the trachea. The trachea was the volume that is not shared... tallies provided a more sound result for both the 22? and 45?calculations, as the calculated relative error was below 0.1 and, therefore is generally reliable by MCNP TM standards. However, neither of the *F8 tallies were below the 0.1 reference value...

  11. Ultrastructural development of the rat corpus luteum

    E-Print Network [OSTI]

    Bailey, John Franklin

    1971-01-01T23:59:59.000Z

    througn semi-micro dissection of the ovary, tissue differentation in some fields of view was d. ifficult and classification as to cell type was virtually impossible. By comparison of intracellular structure and. inclusions with the work of previous...hitehoiise q r ~ T stiiy y of tne ultr structu. "e of the d. velopin' corpus lu eum cells;ias carried out. The rats::ere sacrificed according to their st-, -. e of estrous, eiid their ovaries removed immediately before dicath. The tissue was fixed in 25...

  12. DOE/ER-0442

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed Newcatalyst phases onOrganizationElectronic Reading2Q)382 THE HUMAN GENOME2 Executive

  13. DJS CLAIM ER

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed Newcatalyst phases onOrganization FY Middle SchoolARM-TR-01468This4t c 5 "NEUTR

  14. Analysis of FY 2005/2006 Hydrologic Testing and Sampling Results for Well ER-12-4, Nevada Test Site, Nye County, Nevada, Rev. No.: 0

    SciTech Connect (OSTI)

    Bill Fryer

    2006-09-01T23:59:59.000Z

    This report documents the analysis of data collected for ER-12-4 during the fiscal year (FY) 2005 Rainier Mesa/Shoshone Mountain well development and hydraulic testing program (herein referred to as the ''testing program'') and hydraulic response data from the FY 2006 Sampling Program. Well ER-12-4 was constructed and tested as a part of the Corrective Action Unit (CAU) 99, Rainier Mesa/Shoshone Mountain, Phase I drilling program during FY 2005. These activities were conducted on behalf of the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO) for the Underground Test Area (UGTA) Subproject. As shown on Figure 1-1, ER-12-4 is located in central Rainier Mesa, in Area 12 of the Nevada Test Site (NTS). Figure 1-2 shows the well location in relation to the tunnels under Rainier Mesa. The well was drilled to a total depth (TD) of 3,715 feet (ft) below ground surface (bgs) (surface elevation 6,883.7 ft above mean sea level [amsl]) in the area of several tunnels mined into Rainier Mesa that were used historically for nuclear testing (NNSA/NSO, 2006). The closest nuclear test to the well location was MIGHTY OAK (U-12t.08), conducted in the U-12t Tunnel approximately 475 ft north of the well site. The MIGHTY OAK test working point elevation was located at approximately 5,620 ft amsl. The MIGHTY OAK test had an announced yield of ''less than 20 kilotons'' (DOE/NV, 2000). The purpose of this hydrogeologic investigation well is to evaluate the deep Tertiary volcanic section below the tunnel level, which is above the regional water table, and to provide information on the section of the lower carbonate aquifer - thrust plate (LCA3), located below the Tertiary volcanic section (SNJV, 2005b). Details on the drilling and completion program are presented in the ''Completion Report for Well ER-12-4 Corrective Action Unit 99: Rainier Mesa-Shoshone Mountain'' (NNSA/NSO, 2006). Participants in ER-12-4 testing activities were: Stoller-Navarro Joint Venture (SNJV), Bechtel Nevada (BN), Desert Research Institute (DRI), Los Alamos National Laboratory (LANL), Lawrence Livermore National Laboratory (LLNL), and the U.S. Geological Survey (USGS). Stoller-Navarro Joint Venture served as the lead contractor responsible for providing site supervision, development and testing services, and waste management services; BN provided construction and engineering support services; DRI provided well logging services and participated in groundwater sampling and laboratory analyses; LANL and LLNL participated in groundwater sampling and laboratory analyses; and the USGS performed laboratory analyses. Analyses of data from the ER-12-4 testing program presented in this document were performed by SNJV except as noted. These same contractors participated in the FY 2006 Sampling Program.

  15. Frequency upconversion in Er{sup 3+} doped Y{sub 2}O{sub 3} nanophosphor:Yb{sup 3+} sensitization and tailoring effect of Li{sup +} ion

    SciTech Connect (OSTI)

    Mishra, K. [Laser and Spectroscopy Laboratory, Department of Physics, Banaras Hindu University, Varanasi 221005 (India); Singh, S.K., E-mail: sunilcfsl@gmail.com [Department of Physics, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005 (India); Singh, A.K. [School of Materials Science and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005 (India); Rai, S.B., E-mail: sbrai49@yahoo.co.in [Laser and Spectroscopy Laboratory, Department of Physics, Banaras Hindu University, Varanasi 221005 (India)

    2013-10-15T23:59:59.000Z

    Graphical abstract: - Highlights: Dual mode luminescence behavior of Er{sup 3+} in oxide phosphor. Sensitization through Yb{sup 3+} codoping, and tailoring effect of lithium ion. Phosphors for lighting and display applications. - Abstract: Er{sup 3+} doped Y{sub 2}O{sub 3} nanophosphor has been synthesized using solution combustion technique and further characterized for structure and optical properties. Optical properties of Er{sup 3+} ion have been studied both through frequency upconversion (UC) as well as through fluorescence (excitation, emission, and CIE co-ordinate analysis) processes. Further to enhance the UC emission of Er{sup 3+} ions, a two step process has been used. In the first step, Yb{sup 3+} ion has been co-doped, which acts as the sensitizer for Er{sup 3+} through energy transfer process. In the second step, different concentrations of Li{sup +} ions have been co-doped in the Er{sup 3+}/Yb{sup 3+}:Y{sub 2}O{sub 3} system. Fourier transform infrared analysis, and X-ray diffraction (XRD) followed by Le-Bail refinement of the XRD data reveal that the co-doping of Li{sup +} ion decreases unit cell parameter, increases the particle size, and removes the quenching centers (like OH, NO{sub x}, etc.), which all together causes a significant enhancement in UC emission. Optimum UC luminescence is attained for 5 mol% Li{sup +} doping concentration beyond which a quenching in UC emission is observed. This combined approach, i.e. Yb{sup 3+} sensitization and Li{sup +} ion tailoring simultaneously enhances the UC emission intensity of Er{sup 3+} several times in yttria matrix effectively. The strategy can be generalized in other hosts also which could help in the development of efficient photonic materials for lighting and display devices.

  16. AMPA-receptor mediated plasticity within the rat spinal cord

    E-Print Network [OSTI]

    Hoy, Kevin Corcoran

    2009-05-15T23:59:59.000Z

    Previous research from our laboratory has demonstrated that the spinal cord is capable of a simple form of instrumental learning. In this instrumental learning paradigm, rats typically receive a complete spinal transection at the second thoracic...

  17. adult rats rattus: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 IMPACTS OF INTRODUCED NORWAY RATS (RATTUS NORVEGICUS) ON LEAST AUKLETS (AETHIA PUSILLA) BREEDING AT KISKA ISLAND,...

  18. Solution Processed MoS2-PVA Composite for Sub-Bandgap Mode-Locking of a Wideband Tunable Ultrafast Er:Fiber Laser

    E-Print Network [OSTI]

    Zhang, Meng; Howe, Richard C. T.; Woodward, Robert I.; Kelleher, Edmund J. R.; Torrisi, Felice; Hu, Guohua; Popov, Sergei V.; Taylor, J. Roy; Hasan, Tawfique

    2014-11-11T23:59:59.000Z

    with stable, picosecond pulses, tunable from 1535 nm to 1565 nm 2 Solution Processed MoS2-PVA Composite for Sub-Bandgap Mode-Locking of a Wideband Tunable Ultrafast Er:Fiber Laser Meng Zhang1, Richard C. T. Howe2, Robert I. Woodward1... ! to! relaxation! of! thermalized! electron! and!phonon! distribution! [3].! This! combination! of!properties!makes!MoS2!a!suitable!saturable!absorber!(SA)! for! ultrafast! mode+locked! pulsed! lasers,! with!the! potential! for! pulse! generation! at...

  19. Identification of LAMBDA-like systems in Er{sup 3+}:Y{sub 2}SiO{sub 5} and observation of electromagnetically induced transparency

    SciTech Connect (OSTI)

    Baldit, E.; Bencheikh, K.; Monnier, P.; Briaudeau, S.; Levenson, J. A.; Crozatier, V.; Lorgere, I.; Bretenaker, F.; Le Goueet, J. L.; Guillot-Noeel, O.; Goldner, Ph. [Laboratoire de Photonique et de Nanstructures, CNRS-UPR 20, 91460 Marcoussis (France); Laboratoire Aime Cotton, CNRS-UPR 3321, University Paris-Sud, Bat. 505, 91405 Orsay Cedex (France); Laboratoire de Chimie de la Matiere Condensee de Paris, CNRS-UMR 7574, ENSCP, 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05 (France)

    2010-04-01T23:59:59.000Z

    Electromagnetically induced transparency (EIT) is reported in a solid-state material doped with erbium ions. In this paper we introduce the spectroscopic investigations we have conducted in order to identify the adequate LAMBDA-like three-level systems in Er{sup 3+}:Y{sub 2}SiO{sub 5} crystal, relevant for the demonstration of EIT. These results pave the way for nonlinear and quantum optics applications based on EIT at the telecom wavelength around 1.5 mum.

  20. Intracellular protein degradation in cultured rat muscle cells

    E-Print Network [OSTI]

    Miller, Gwendolyn Beth

    1982-01-01T23:59:59.000Z

    1982 Major Subject: Biochemistry INTRACELLULAR PROTEIN DEGRADATION IN CULTURED RAT MUSCLE CELLS A Thesis by GWENDOLYN BETH MILLER Approved as to style and content by: hairman of Committee) p I 'P) (Member) (M r) (Head of Department) August... 1982 "BOGS-'. 4( 3 3q ABSTRACT Intracellular Protein Degradation in Cultured Rat Muscle Cells (August 1982) Gwendolyn Beth Miller, B. S. , Texas Asm Dniversity Chairman of Advisory Committee: Dr. J. martyn Gunn Intra:elMlar protein degradation...

  1. Non-essential amino acid metabolism in rats

    E-Print Network [OSTI]

    Crooks, James Darrell

    2012-06-07T23:59:59.000Z

    NON-ESSENTIAL AMINO ACID METABOLISM IN RATS A Thesis by JAMES DARRELL CROOKS, JR. Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement for the degree of MASTER OF SCIENCE May 1971 Major Subject...: Animal Nutrition O 4 0 E ? NON ESSENTIAL AMINO ACID METABOLISM IN RATS A Thesis by JAMES DARRELL CROOKS& JR. Approved as to style and content by: (Chairman of Committee) (Member) (Head of Department) (Member) May 197 1 ABSTRACT Non...

  2. Preexposure sensitizes rats to the reinforcing effects of cocaine

    E-Print Network [OSTI]

    Horger, Brian Arthur

    2012-06-07T23:59:59.000Z

    PREEXPOSURE SENSITIZES RATS TO THE REINFORCING EFFECTS OF COCAINE A Thesis by BRIAN ARTHUR HORGER Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE May 1990 Major Subject: Psychology PREEXPOSURE SENSITIZES RATS TO THE REINFORCING EFFECTS OF COCAINE A Thesis by BRIAN ARTHUR HORGER Approved as to style and content by: Susan Sch nk ' (Chair of Committee) ~, r, :. ). ~+~~- ?- : Jack R...

  3. Arginine and Conjugated Linoleic Acid Reduce Fat Mass in Rats

    E-Print Network [OSTI]

    Nall, Jennifer L.

    2010-10-12T23:59:59.000Z

    ARGININE AND CONJUGATED LINOLEIC ACID REDUCE FAT MASS IN RATS A Thesis by JENNIFER LYNN NALL Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree... of MASTER OF SCIENCE May 2008 Major Subject: Nutrition ARGININE AND CONJUGATED LINOLEIC ACID REDUCE FAT MASS IN RATS A Thesis by JENNIFER LYNN NALL Submitted to the Office of Graduate Studies Texas A...

  4. Neuroendocrine effects of acute nickel chloride administration in rats

    SciTech Connect (OSTI)

    Clemons, G.K.; Garcia, J.F.

    1981-01-01T23:59:59.000Z

    An sc injection of nickel chloride (20 and 10 mg/kg) led to a profound and consistent increase of circulating prolactin (PRL) levels after 1 day and lasted for 4 days (p < 0.001) in male rats. Increases in insulin levels occurred 1 and 2 days postinjection. The nickel-induced PRL rise could be abolished by a simultaneous administration of 2-bromo-..cap alpha..-ergocryptine (CB 154). In vitro incubation of pituitaries from rats that received 20 mg/kg of nickel chloride 48 hr prior to sacrifice released more PRL into the culture medium, as well as contained more PRL in the final tissue than did the pituitaries from control animals. The hypothalamic extracts (HE) obtained from hypothalami of nickel-injected rats were tested also in vitro on normal rat pituitaries and the results showed that the HE from such rats released more PRL and therefore had less prolactin-inhibiting factor (PIF) than the HE obtained from control rats. The results show that nickel chloride has effects on the endocrine system that (a) last considerably longer than previously reported, (b) are mediated through the neuroendocrine system, and (c) instead of specifically inhibiting PRL secretion from the pituitary promote high circulating PRL levels lasting from 1 to 4 days.

  5. Toxicologic and biochemical effects of extracts from Karwinskia humboldtiana on the albino rat

    E-Print Network [OSTI]

    Wheeler, Michael Hugh

    1970-01-01T23:59:59.000Z

    ) received empty gelatin capsules once each week for seven weeks. Group IV-C contained six control rats, and these rats were not fed Ch-3. The treated rats in Group IV-A and the control rats in Group IV-C were fed Purina Rat Chow ad libitum throughout... the study. The treated animals in Group IV-A were individually killed by decapitation and necropsied when it appeared they were in a moribund condition. Rats in Groups IV-B and IV-C were killed and necropsied on the BBth day. Blood samples were collected...

  6. Analysis of nanostructure and nanochemistry by ASAXS: Accessing phase composition of oxyfluoride glass ceramics doped with Er{sup 3+}/Yb{sup 3+}

    SciTech Connect (OSTI)

    Haas, Sylvio; Hoell, Armin; Wurth, Roman; Ruessel, Christian; Boesecke, Peter; Vainio, Ulla [Institute of Applied Materials, Helmholtz-Zentrum Berlin fuer Materialien und Energie, Albert-Einstein-Strasse 15, D-12489 Berlin (Germany); Otto-Schott-Institut fuer Glaschemie, Friedrich-Schiller-Universitaet Jena, Fraunhoferstrasse 6, D-07743 Jena (Germany); European Synchrotron Radiation Facility (ESRF), 6 Rue Jules Horowitz, BP 220, 38043 Grenoble Cedex 9 (France); HASYLAB at DESY, Notkestrasse 85, D-22607 Hamburg (Germany)

    2010-05-01T23:59:59.000Z

    Here, we describe the analysis of the nanostructure and average chemical compositions of each phase present in an oxyfluoride glass ceramic, which is composed of fluoride nanocrystals and an oxide glass matrix. The overall composition of the oxyfluoride glass ceramic as prepared is 21.1%SiO{sub 2} 6.5%B{sub 2}O{sub 3} 7.0%Al{sub 2}O{sub 3} 21.0%PbF{sub 2} 14.3%CdF{sub 2} 11.0%YbF{sub 3} 0.5%ErF{sub 3} 11.0%PbO 7.6%CdO(mole %). Nanocrystals begin to grow at temperatures above the glass transformation temperature at 678 K as observed by x-ray diffraction. We report results from anomalous small-angle x-ray scattering taken at energies of x-ray absorption edges of Er, Yb, Pb, and Cd. By nonlinear regression of the scattering curves obtained from different edges simultaneously, the nanocrystals were found to be describable as polydisperse spheroids. The length of the smaller axis was found to be 6.4+-1.4 nm while the larger axis was found to be 17.7+-3.9 nm. By analyzing the scattering contrast as a function of the x-ray energy we found cadmium only in the glass matrix.

  7. Er{sup 3+}-doped strontium lithium bismuth borate glasses for broadband 1.5 {mu}m emission - optical properties

    SciTech Connect (OSTI)

    Rajesh, D.; Balakrishna, A.; Ratnakaram, Y. C. [Department of Physics, Sri Venkateswara University, Tirupati-517502 (India)

    2013-02-05T23:59:59.000Z

    Strontium lithium bismuth borate glasses (SLBiB) doped with various concentrations of Er{sup 3+} were prepared using conventional melt quench technique and investigated their optical properties. The amorphous nature of the prepared glass samples was confirmed by X-ray diffraction and SEM analysis. Optical properties were studied by measuring the optical absorption and near infrared luminescence spectra at room temperature. Judd-Ofelt (J-O) theory has been applied for the f.f transitions of Er{sup 3+} ions to evaluate J-O intensity parameters, {Omega}{lambda} ({lambda} = 2, 4 and 6). Using the J-O intensity parameters, radiative properties such as transition probabilities (A{sub R}), branching ratios ({beta}) and radiative lifetimes ({tau}) are estimated for certain transitions. From the emission spectra, peak emission-cross sections ({sigma}{sub p}) and products of stimulated emission cross-section and full width at half maximum ({sigma}{sub p} Multiplication-Sign FWHM) were calculated for the observed emission transition, {sup 4}I{sub 13/2}{yields}{sup 4}I{sub 15/2}.

  8. Synthesis of solid solution Er{sub 2-x}Ce{sub x}W{sub 3}O{sub 12} and studies of their thermal expansion behavior.

    SciTech Connect (OSTI)

    Wu, M. M.; Cheng, Y. Z.; Peng, J.; Xiao, X. L.; Chen, D. F.; Kiyanagi, R.; Fieramosca, J. S.; Short, S.; Jorgensen, J.; Hu, Z. B.; Graduate Univ. Chinese Academy of Sciences; China Inst. of Atomic Energy

    2007-01-30T23:59:59.000Z

    The syntheses and structures of Er{sub 2-x}Ce{sub x}W{sub 3}O{sub 12} were studied. It was found that pure phases could form only for 0.0 {le} x {le} 0.4 and 1.5 {le} x {le} 2.0. Compounds with 0 {le} x {le} 0.4 have the hydrated orthorhombic structure at room temperature and transform to unhydrated orthorhombic one above 135 C whereas samples with 1.5 {le} x {le} 2.0 crystallize in monoclinic structure. Thermal expansion properties of Er{sub 2-x}Ce{sub x}W{sub 3}O{sub 12} were studied with high temperature X-ray powder diffraction. Samples with 0 {le} x {le} 0.4 exhibit negative thermal expansion in temperature range of 200-800 C and higher cerium content leads to more negative thermal expansion coefficient. However, compounds with 1.5 {le} x {le} 2.0 show positive thermal expansion owing to the edge-sharing polyhedra.

  9. Temperature dependence of Er{sup 3+} ionoluminescence and photoluminescence in Gd{sub 2}O{sub 3}:Bi nanopowder

    SciTech Connect (OSTI)

    Boruc, Zuzanna, E-mail: z.boruc@stud.elka.pw.edu.pl; Fetli?ski, Bartosz; Kaczkan, Marcin; Malinowski, Micha? [Institute of Microelectronics and Optoelectronics, Warsaw University of Technology, ul. Koszykowa 75, 00-662 Warsaw (Poland); Gawlik, Grzegorz [Institute of Electronic Materials Technology, ul. Wolczynska 133, 01-919 Warsaw (Poland)

    2014-06-15T23:59:59.000Z

    Ionoluminescence (IL) and photoluminescence (PL) of trivalent erbium ions (Er{sup 3+}) in Gd{sub 2}O{sub 3} nanopowder host activated with Bi{sup 3+} ions has been studied in order to establish the link between changes in luminescent spectra and temperature of the sample material. IL measurements have been performed with H{sub 2}{sup +} 100 keV ion beam bombarding the target material for a few seconds, while PL spectra have been collected for temperatures ranging from 20?C to 700?C. The PL data was used as a reference in determining the temperature corresponding to IL spectra. The collected data enabled the definition of empirical formula based on the Boltzmann distribution, which allows the temperature to be determined with a maximum sensitivity of 9.7 10{sup ?3}?C{sup ?1}. The analysis of the Er{sup 3+} energy level structure in terms of tendency of the system to stay in thermal equilibrium, explained different behaviors of the line intensities. This work led to the conclusion that temperature changes during ion excitation can be easily defined with separately collected PL spectra. The final result, which is empirical formula describing dependence of fluorescence intensity ratio on temperature, raises the idea of an application of method in temperature control, during processes like ion implantation and some nuclear applications.

  10. Final Technical Report for DOE DE-FG02-05ER54831 "Laboratory Studies of Dynamos."

    SciTech Connect (OSTI)

    Forest, Cary B. [UW-Madison

    2014-11-06T23:59:59.000Z

    Laboratory Studies of Dynamos: Executive Summary. The self-generation of magnetic #12;fields by astrophysical bodies like planets, stars, accretion disks, galaxies, and even galaxy clusters arises due to a mechanism referred to as a homogeneous dynamo. It is quite simple to demonstrate the generation of a magnetic fi#12;eld from a rotating copper disk coupled with a coil of wire, a device known as the homopolar dynamo. The device works like a magnetic fi#12;eld ampli#12;er with a feedback circuit: the differential rotation of a metal disk past an infinitesimally small seed magnetic field induces currents in the disk which, when coupled to a coil winding, can amplify the #12;field until it becomes strong enough to slow the rotation of the disk. What is remarkable is that the same type of circuit may be achieved in a flowing conducting fluid such as a liquid metal in the case of planetary dynamos or a plasma in the case of astrophysical dynamos. The complexity of describing planetary and stellar dynamos despite their ubiquity and the plethora of observational data from the Earth and the Sun motivates the demonstration of a laboratory homogenous dynamo. To create a homogenous dynamo, one #12;first needs a su#14;fficiently large, fast flow of a highly conducting fluid that the velocity shear in the fluid can bend magnetic #12;field lines. With a high Rm-flow, the magnetic fi#12;eld can be ampli#12;ed by the stretching action provided by di#11;fferential rotation. The other critical ingredient is a flow geometry that provides feedback so that the ampli#12;ed #12;eld reinforces the initial in#12;nitesimal seed #12;field - a mechanism that recreates the feedback provided by the coil of wire in the homopolar dynamo. In the Madison Dynamo Experiment, this combination of magnetic ampli#12;cation and feedback is feasible in the simple geometry of two counter-rotating helical vortices in a 1 meter-diameter spherical vessel #12;lled with liquid sodium. For an optimal helical pitch of the flow the threshold for exciting a dynamo is predicted from laminar flow modeling to be at peak flow speeds of 5 m/s. Liquid metals tend to have viscosities similar to that of water yielding inviscid flows. Whereas the timescale for the dynamo instability is on the resistive dissipation time, the timescale for hydrodynamic instability of the shear layer is quite short meaning that the shear layer required to generate the magnetic #12;eld is broken up by Kelvin-Helmholtz instabilities. The eddies generated by large-scale flow drive instabilities at progressively smaller scale giving rise to a cascade of turbulent eddies driven at the largest scale of the experiment. The major contribution of the Madison Dynamo Experiment has been quantifying the role this turbulence plays in the generation of magnetic #12;elds. Overall, the Madison Dynamo Experiment has now operated for about 1 decade and carried out experiments related to magnetic fi#12;eld generation by turbulent flows of liquid metal. The principle thrust of research and indeed the main scienti#12;fic outcomes are related to how turbulent flows create and transport magnetic fi#12;elds.

  11. E-Print Network 3.0 - awake behaving rats Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    rats Search Powered by Explorit Topic List Advanced Search Sample search results for: awake behaving rats Page: << < 1 2 3 4 5 > >> 1 Stimulus-driven response dynamics of the...

  12. E-Print Network 3.0 - adult rat central Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

  13. E-Print Network 3.0 - adult rat posterodorsal Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

  14. E-Print Network 3.0 - adult rats relate Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

  15. E-Print Network 3.0 - adult rats exposed Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

  16. E-Print Network 3.0 - adult rat offspring Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

  17. E-Print Network 3.0 - adult rats tested Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

  18. E-Print Network 3.0 - adult rats potential Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

  19. E-Print Network 3.0 - adult rats relationship Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

  20. E-Print Network 3.0 - adult rats efeito Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

  1. E-Print Network 3.0 - adult rats treated Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

  2. E-Print Network 3.0 - adult rat type Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult rats deposited urine...

  3. E-Print Network 3.0 - acid-deficient hairless rat Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    with hairless rat skin mounted... of the gel was made by contact with a Kodak BioMax MR film (France). Animals Female hairless rats (OFA... as to obtain 20 mg b-lactoglobulin per...

  4. E-Print Network 3.0 - adult rat pancreas Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    -expressing vector as 5 doses between 27 and 39 h after the first dose of HGF into young adult rats (data not shown... , Thyroid, Spleen, and Colon in Rats in Vivo Cuihua ......

  5. Effect of Mn doping on structural and magnetic susceptibility of C-type rare earth nano oxides Er{sub 2?x}Mn{sub x}O{sub 3}

    SciTech Connect (OSTI)

    Heiba, Zein K. [Ain Shams University, Faculty of Science, Physics Department, Cairo (Egypt) [Ain Shams University, Faculty of Science, Physics Department, Cairo (Egypt); Taif University, Faculty of Science, Physics Department (Saudi Arabia); Mohamed, Mohamed Bakr, E-mail: mbm1977@yahoo.com [Ain Shams University, Faculty of Science, Physics Department, Cairo (Egypt); Fuess, H. [Materials Science, Darmstadt University of Technology, D-64289 Darmstadt (Germany)] [Materials Science, Darmstadt University of Technology, D-64289 Darmstadt (Germany)

    2012-12-15T23:59:59.000Z

    Graphical abstract: Display Omitted Highlights: ? Er{sub 2?x}Mn{sub x}O{sub 3} (0.0 ? x ? 0.20) prepared by solgel method. ? The change in lattice parameter is not linear with x due to the change in crystallite size with doping. ? Anomalous concentration dependence is found in magnetic susceptibility. ? The effective magnetic moment ?{sub eff} is found to decrease with composition parameter x. ? Superexchange interactions between Er ions depending on the amount of Mn or Er in different sites. -- Abstract: The manganese doped rare earth oxides Er{sub 2?x}Mn{sub x} O{sub 3} (0.0 ? x ? 0.20) were synthesized by a solgel process and analyzed by X-ray diffraction using Rietveld refinement methods. A single phase solid solution is formed up to x = 0.15 while for x ? 0.2 a manganese oxide phase appears in the diffraction pattern. Preferential cationic distribution between the non-equivalent sites 8b and 24d of space group Ia3{sup } is found for all samples but to a different extent. The octahedral volume and average bond length of Er{sub 1}-O for 8b site decrease while both octahedral volume and bond length of Er{sub 2}-O for 24d site increase. Magnetization measurements were done in the temperature range 5300 K. The effective magnetic moment ?{sub eff} is found to decrease with composition parameter x, except for sample x = 0.05 where the magnetization is enhanced. The Curie-Weiss paramagnetic temperatures indicate antiferromagnetic interaction.

  6. Circadian rhythms on hypothalamicpituitaryadrenal axis hormones and cytokines of collagen induced arthritis in rats

    E-Print Network [OSTI]

    Li, Shao

    with corresponding circadian fluctuations in cytokines in a rat model of collagen-induced arthritis (CIA). CIA adjuvant at the left foot. On day 33, in both the CIA and the control rats, circulating adrenocorticotropin-rhythmometry. The results showed that plasma corticosterone in CIA rats had a trough at 18:00 and reached a peak at 06

  7. Assessing the effects of Norway rats on auklet breeding success and survival at Sirius Point, Kiska

    E-Print Network [OSTI]

    Jones, Ian L.

    Assessing the effects of Norway rats on auklet breeding success and survival at Sirius Point, Kiska Introduction The presence of introduced Norway rats (Rattus norvegicus) has been implicated as a possible sightings of Norway rats at Sirius Point Colony during the late 1980s and early 1990s. Furthermore

  8. Marine Ornithology 41: 4148 (2013) Bond et al.: Crested Auklet survival with Norway Rats 41

    E-Print Network [OSTI]

    Jones, Ian L.

    Marine Ornithology 41: 41­48 (2013) Bond et al.: Crested Auklet survival with Norway Rats 41 in the Aleutians (Bailey 1993, Ebbert & Byrd 2002). Another introduced predator, the Norway rat Rattus norvegicus AND REPRODUCTIVE SUCCESS OF CRESTED AUKLETS AETHIA CRISTATELLA IN THE PRESENCE OF INTRODUCED NORWAY RATS RATTUS

  9. Variations in the diet of introduced Norway rats (Rattus norvegicus) inferred using stable isotope analysis

    E-Print Network [OSTI]

    Jones, Ian L.

    Variations in the diet of introduced Norway rats (Rattus norvegicus) inferred using stable isotope predators; island ecosystem conservation; stable isotope analysis; Norway rats; diet. Correspondence Heather of introduced Norway rats Rattus norvegicus has raised concerns for the fate of the large least auklet Aethia

  10. Stimulus Control of Maternal Responsiveness to Norway Rat (Rattus norvegicus) Pup Ultrasonic Vocalizations

    E-Print Network [OSTI]

    Stimulus Control of Maternal Responsiveness to Norway Rat (Rattus norvegicus) Pup Ultrasonic be considered a specialization of Norway rats and other small rodents. When removed from the nest and placed in a cool environment, infant Norway rats emit USVs. These vocalizations range from 30 to 50 k

  11. Serum proteins in magnesium-deficient rat Y. RAYSSIGUIER P. LARVOR Y. AUGUSTI J. DURLACH

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Serum proteins in magnesium-deficient rat Y. RAYSSIGUIER P. LARVOR Y. AUGUSTI J. DURLACH (1 Cochin, Paris Summary. Hypoproteinemia appears early in the magnesium-deficient rat with a drop in serum. In the magnesium-deficient rat, we have shown serum protein modifications related to immunologic and allergic

  12. Dietary L-arginine supplementation reduces fat mass in diet-induced obese rats

    E-Print Network [OSTI]

    Jobgen, Wenjuan Shi

    2009-06-02T23:59:59.000Z

    This study was conducted to test the hypothesis that dietary arginine supplementation reduces fat mass in diet-induced obese rats. Male Sprague-Dawley rats were fed either low- or high-fat diets for 15 wks (16 rats/diet). Thereafter, lean or obese...

  13. E-Print Network 3.0 - aging female rats Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    DAMAGE POTENTIAL OF THREE RODENT SPECIES ON Summary: : 0.39 0.03g; female cotton rats: 0.34 0.03g; male roof rats:0.25 0.04g; female roof rats:0... .26 0.04g;...

  14. Inhalation developmental toxicology studies: Acetonitrile in rats. Final report

    SciTech Connect (OSTI)

    Mast, T.J.; Weigel, R.J.; Westerberg, R.B.; Boyd, P.J.; Hayden, B.K.; Evanoff, J.J.; Rommereim, R.L.

    1994-02-01T23:59:59.000Z

    The potential for acetonitrile to cause developmental toxicity was assessed in Sprague-Dawley rats exposed to 0, 100, 400, or 1200 ppM acetonitrile, 6 hours/day, 7 days/week. Exposure of rats to these concentrations of acetonitrile resulted in mortality in the 1200 ppM group (2/33 pregnant females; 1/10 non-pregnant females). However, there were no treatment-related effects upon body weights or reproduction indices at any exposure level, nor was there a significant increase in the incidence of fetal malformations or variations. The only effect observed in the fetuses was a slight, but not statiscally significant, exposure-correlated increase in the incidence of supernumerary ribs. Determination of acetonitrile and cyanide concentrations in maternal rat blood showed that acetonitrile concentration in the blood increased with exposure concentration for all exposed maternal rats. Detectable amounts of cyanide in the blood were found only in the rats exposed to 1200 ppM acetonitrile ({approximately}2 {mu}g cyanide/g of blood).

  15. Sexual differences in the expression of copper deficiency in rats

    SciTech Connect (OSTI)

    Fields, M.; Lewis, C.G.; Beal, T.; Scholfield, D.; Patterson, K.; Smith, J.C.; Reiser, S.

    1987-11-01T23:59:59.000Z

    The present investigation was undertaken to establish whether the severity of copper deficiency in rats fed diets containing fructose is affected by the presence and type of endogenous sex hormones. Intact and castrated male rats and intact and ovariectomized females were fed from weaning a copper-deficient diet (0.6 ppm) containing 62% fructose for 8 weeks. Regardless of castration, male rats were anemic, exhibited heart hypertrophy, and died of the deficiency. However, castration ameliorated the anemia and delayed the mortality. In contrast, none of the females died of the deficiency. It is suggested that in addition to the sex of the animal, levels of testosterone in the male may also play a role in the severity of copper deficiency.

  16. Wideband saturable absorption in few-layer molybdenum diselenide (MoSe2) for Q-switching Yb-, Er- and Tm-doped fiber lasers

    E-Print Network [OSTI]

    Woodward, R I; Runcorn, T H; Hu, G; Torrisi, F; Kelleher, E J R; Hasan, T

    2015-01-01T23:59:59.000Z

    We fabricate a free-standing molybdenum diselenide (MoSe2) saturable absorber by embedding liquid-phase exfoliated few-layer MoSe2 flakes into a polymer film. The MoSe2-polymer composite is used to Q-switch fiber lasers based on ytterbium (Yb), erbium (Er) and thulium (Tm) gain fiber, producing trains of microsecond-duration pulses with kilohertz repetition rates at 1060 nm, 1566 nm and 1924 nm, respectively. Such operating wavelengths correspond to sub-bandgap saturable absorption in MoSe2, which is explained in the context of edge-states, building upon studies of other semiconducting transition metal dichalcogenide (TMD)-based saturable absorbers. Our work adds few-layer MoSe2 to the growing catalog of TMDs with remarkable optical properties, which offer new opportunities for photonic devices.

  17. Analysis of In situ Observations of Cloud Microphysics from M-PACE Final Report, DOE Grant Agreement No. DE-FG02-06ER64168

    SciTech Connect (OSTI)

    Michael R. Poellot

    2009-01-09T23:59:59.000Z

    This report summarizes the findings and accomplishments of work performed under DOE Grant Agreement No. DE-FG02-06ER64168. The focus of the work was the analysis of in situ observations collected by the University of North Dakota Citation research aircraft during the Mixed-Phase Arctic Cloud Experiment (M-PACE). This project was conducted in 2004 along the North Slope of Alaska. The objectives of the research were: to characterize certain microphysical properties of clouds sampled during M-PACE, including spatial variability, precipitation formation, ice multiplication; to examine instrument performance and certain data processing algorithms; and to collaborate with other M-PACE investigators on case study analyses. A summary of the findings of the first two objectives is given here in parts 1 and 2; full results are contained in reports listed in part 3 of this report. The collaborative efforts are described in the publications listed in part 3.

  18. Synthesis and characterization of ultrafine Ln{sub 2}Ti{sub 2}O{sub 7} (Ln = Sm, Gd, Dy, Er) pyrochlore oxides by stearic acid method

    SciTech Connect (OSTI)

    Zhang Weiguang, E-mail: zhangweiguang68@yahoo.com.cn [Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, Huaiyin Normal University, Jiangsu Province, 223300 (China); Zhang Lili; Zhong Hui [Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, Huaiyin Normal University, Jiangsu Province, 223300 (China); Lu Lude; Yang Xujie [Materials Chemistry Laboratory, Nanjing University of Science and Technology, Nanjing 210094 (China); Wang Xin, E-mail: wangx@mail.njust.edu.cn [Materials Chemistry Laboratory, Nanjing University of Science and Technology, Nanjing 210094 (China)

    2010-02-15T23:59:59.000Z

    Stearic acid method (SAM) was developed to synthesize series of pyrochlore Ln{sub 2}Ti{sub 2}O{sub 7} (Ln = Sm, Gd, Dy, Er) nanocrystals. The synthesis process was monitored by X-ray diffraction, Thermal-gravimetric-differential thermal analysis and Fourier Transform InfraRed methods. Comparing with traditional solid-state reaction (SSR), Ln{sub 2}Ti{sub 2}O{sub 7} can be synthesized at relatively low temperature (700-800 deg. C) with shortened reaction time (2-4 h). The average particle size of Ln{sub 2}Ti{sub 2}O{sub 7} was greatly reduced (ca. 40 nm) and the BET surface area was increased (ca. 12 m{sup 2}/g) by using SAM. From the X-ray diffraction patterns, we found that Ln has an effect on the crystal structure of Ln{sub 2}Ti{sub 2}O{sub 7}, every lattice peak shifted to larger angle slightly with the increasing atomic number of Ln. Also, the lattice constant of Ln{sub 2}Ti{sub 2}O{sub 7} was calculated by Jade.5 and found it decreased along with the decrease of ionic radius of Ln{sup 3+}. The morphology of obtained Ln{sub 2}Ti{sub 2}O{sub 7} was determined by transmission electron microscopy technique. Results showed that the obtained Ln{sub 2}Ti{sub 2}O{sub 7} were all square-like and the interplanar distance of Ln{sub 2}Ti{sub 2}O{sub 7} (Ln = Sm, Gd, Dy, Er) according to (111) plane was 0.65, 0.64, 0.63, and 0.62 nm respectively, which was measured from High Resolution Transmission Electron Microscopy images. Possible reason for this phenomenon was presented.

  19. Experimental cross sections of 165Ho(?,n)168Tm and 166Er(?,n)169Yb for optical potential studies relevant for the astrophysical ?-process

    E-Print Network [OSTI]

    Jan Glorius; Kerstin Sonnabend; Joachim Goerres; Daniel Robertson; Michael Knoerzer; Antonios Kontos; Thomas Rauscher; Ren Reifarth; Anne Sauerwein; Edward Stech; Wanpeng Tan; Tanija Thomas; Michael Wiescher

    2014-07-07T23:59:59.000Z

    Background: Optical potentials are crucial ingredients for the prediction of nuclear reaction rates needed in simulations of the astrophysical \\gamma-process. Associated uncertainties are particularly large for reactions involving \\alpha-particles. This includes (\\gamma,\\alpha) reactions which are of special importance in the \\gamma-process. Purpose: The measurement of (\\alpha,n) reactions allows for an optimization of currently used \\alpha-nucleus potentials. The reactions 165Ho(\\alpha,n) and 166Er(\\alpha,n) probe the optical model in a mass region where \\gamma-process calculations exhibit an underproduction of p nuclei which is not yet understood. Method: To investigate the energy-dependent cross sections of the reactions 165Ho(\\alpha,n) and 166Er(\\alpha,n) close to the reaction threshold, self-supporting metallic foils were irradiated with \\alpha-particles using the FN tandem Van de Graaff accelerator at University of Notre Dame. The induced activity was determined afterwards by monitoring the specific \\beta-decay channels. Results: Hauser-Feshbach predictions with a widely used global \\alpha-potential describe the data well at energies where the cross sections are almost exclusively sensitive to the \\alpha-widths. Increasing discrepancies appear towards the reaction threshold at lower energy. Conclusions: The tested global \\alpha-potential is suitable at energies above 14 MeV, while a modification seems necessary close to the reaction threshold. Since the \\gamma- and neutron width show non-negligible impact on the predictions, complementary data are required to judge whether or not the discrepancies found can to be solely assigned to the \\alpha-width.

  20. Enhanced 2.7 ?m emission from Er{sup 3+} doped oxyfluoride tellurite glasses for a diode-pump mid-infrared laser

    SciTech Connect (OSTI)

    Zhang, F. F.; Yuan, J.; Chen, D. D.; Qian, Q.; Zhang, Q. Y., E-mail: qyzhang@scut.edu.cn [State Key Laboratory of Luminescence Materials and Devices, and Institute of Optical Communication Materials, South China University of Technology, Guangzhou 510641 (China); Zhang, W. J. [Shandong Provincial Key Laboratory of Preparation and Measurement of Building Materials, University of Jinan, Jinan 250022 (China)] [Shandong Provincial Key Laboratory of Preparation and Measurement of Building Materials, University of Jinan, Jinan 250022 (China)

    2014-04-15T23:59:59.000Z

    The influence of fluoride and shielding gas (O{sub 2} or Ar) on the physical and spectroscopic properties of Er{sup 3+} doped TeO{sub 2}-ZnO-ZnF{sub 2} glass system is investigated. The larger electronegativity of F than O accounts for the gradual decrease of refractive index, density, and J-O parameters with increasing ZnF{sub 2}. An analysis on Fourier transform infrared transmission spectra reveals that the absorption coefficient of OH{sup ?} around 3 ?m as low as 0.247 cm{sup ?1} can be achieved when 30 mol% ZnF{sub 2} containing sample is treated with Ar gas during glass melting process. The reduction of OH{sup ?} groups combined with the low multiphonon relaxation rate (207 s{sup ?1}) contributes to the enhanced emissions at 1.5 and 2.7 ?m, along with prolonged lifetimes of {sup 4}I{sub 11/2} and {sup 4}I{sub 13/2} levels. A high branching ratio (17.95%) corresponding to the Er{sup 3+}: {sup 4}I{sub 11/2} ? {sup 4}I{sub 13/2} transition, the large absorption and emission cross section (0.44 10{sup ?20} cm{sup 2} and 0.45 10{sup ?20} cm{sup 2}), and good gain cross section demonstrate that oxyfluoride tellurite glass could be a promising material for a diode-pump 2.7 ?m fiber laser.

  1. Apport de l'imagerie radar SAR-ERS l'analyse de la gomtrie de la dformation rcente dans les monts Bni Snassen (Maroc) PANGEA No. 45/46 Hassan Tabyaoui et al. June / December 2009

    E-Print Network [OSTI]

    Boyer, Edmond

    monts Béni Snassen (Maroc) PANGEA No. 45/46 Hassan Tabyaoui et al. June / December 2009 18 Apport de l (Maroc nord-oriental) Contribution of the imagery radar SAR-ERS to the analysis of the geometry Modélisation, Equipe Risques Naturels, Aménagement des Territoires et Environnement, BP 1223, Taza-Gare, Maroc

  2. Magnetic properties and magnetocaloric effect in the RCu{sub 2}Si{sub 2} and RCu{sub 2}Ge{sub 2} (R?=?Ho, Er) compounds

    SciTech Connect (OSTI)

    Mo, Zhao-Jun [School of Material Science and Engineering, Hebei University of Technology, Tianjin (China); Key laboratory of cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing (China); Shen, Jun, E-mail: jshen@mail.ipc.ac.cn, E-mail: tangcc@hebut.edu.cn; Wu, Jian-Feng [Key laboratory of cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing (China); Yan, Li-Qin; Wang, Li-Chen; Sun, Ji-rong; Shen, Bao-Gen [State Key Laboratory of Magnetism, Beijing National Laboratory for Condensed Matter, Physics and Institute of Physics, Chinese Academy of Sciences, Beijing (China); Gao, Xin-Qiang; Tang, Cheng-Chun, E-mail: jshen@mail.ipc.ac.cn, E-mail: tangcc@hebut.edu.cn [School of Material Science and Engineering, Hebei University of Technology, Tianjin (China)

    2014-02-21T23:59:59.000Z

    The magnetic properties and magnetocaloric effect (MCE) in RCu{sub 2}Si{sub 2} and RCu{sub 2}Ge{sub 2} (R?=?Ho, Er) compounds have been investigated. All these compounds possess an antiferromagnetic (AFM)-paramagnetic (PM) transition around their respective Neel temperatures. The RCu{sub 2}Si{sub 2} compounds undergo spin-glassy behavior above Neel temperature. Furthermore, a field-induced metamagnetic transition from AFM to ferromagnetic (FM) states is observed in these compounds. The calculated magnetic entropy changes show that all RCu{sub 2}Si{sub 2} and RCu{sub 2}Ge{sub 2} (R?=?Ho, Er) compounds, especially, ErCu{sub 2}Si{sub 2} exhibits large MCEs with no thermal hysteresis and magnetic hysteresis loss. The value of ??S{sub M}{sup max} reaches 22.8?J/Kg K for magnetic field changes from 0 to 5?T. In particular, for field changes of 1 and 2?T, the giant reversible magnetic entropy changes ??S{sub M}{sup max} are 8.3 and 15.8?J/kg K at 2.5?K, which is lower than the boiling point of helium. The low-field giant magnetic entropy change, together with ignorable thermal hysteresis and field hysteresis loss of ErCu{sub 2}Si{sub 2} compound is expected to have effective applications in low temperature magnetic refrigeration.

  3. The laboratory rat strains most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia

    E-Print Network [OSTI]

    Shihadeh, Alan

    and the nude rat. Uses Despite the fear that rats invoke in people they actually make quiet, gentle pets rate 70-115 Food consumption 5-6g/100g/d Water consumption 10-12ml/100g/d Breeding onset Male 65-110d

  4. Regional neurohypophysial and hypothalamic blood flow in rats during hypercapnia

    SciTech Connect (OSTI)

    Bryan, R.M. Jr.; Myers, C.L.; Page, R.B.

    1988-08-01T23:59:59.000Z

    Regional cerebral blood flow (rCBF) was measured in the neurohypophysis and hypothalamus in normocapnic and hypercapnic rats using (/sup 14/C)isopropyliodoamphetamine. Rats were surgically prepared using nitrous oxide and halothane and placed in plaster restraining casts. Hypercapnia was produced by increasing the fractional concentration of inspired CO/sub 2/ (FICO/sub 2/). rCBF in normocapnic rats was higher in the paraventricular nucleus, supraoptic nucleus, median eminence, and neural lobe than rates previously measured by use of diffusible tracers. During hypercapnia blood flow increased linearly with arterial PCO/sub 2/ (PACO/sub 2/) in all regions except the median eminence and neural lobe, which were not affected by hypercapnia. When rats were pretreated with phentolamine (1 mg/kg) to block the alpha-adrenergic receptors, blood flow in the median eminence and neural lobe increased significantly during hypercapnia. We conclude that blood flow in the cell bodies of the paraventricular nucleus and supraoptic nucleus is regulated differently during hypercapnia than blood flow in the nerve terminals in the median eminence and neural lobe. Furthermore, vasodilation produced by increased CO/sub 2/ is offset by alpha-receptor stimulation in the median eminence and neural lobe.

  5. Characterization of a plasma membrane zinc transporter in rat brain

    E-Print Network [OSTI]

    Ireland Ltd. Keywords: Ion transport; Membrane vesicles; Excitotoxicity; Zinc homeostasis; TransitionCharacterization of a plasma membrane zinc transporter in rat brain Robert A. Colvin* Department transport in the brain. This report provides convincing evidence of a zinc transporter in plasma membrane

  6. PROTECTIVE EFFECTS OF VERAPAMIL AGAINST HEXACHLOROBUTADIENE NEPHROTOXICITY IN RATS

    E-Print Network [OSTI]

    E. Moghtadai Khorasgani; K. Manochehri; M. Hosseini

    In order to evaluate the protective effect of verapamil against hexachlorobutadiene (HCBD) nephrotoxicity, 30 adult Wistar albino rats were divided into five equal groups, A, B, C, D and E and were given intra-peritonially corn oil (I ml/kg; control), HCBD (50 mg/kg), verapamil (50 g/kg) with HCBD

  7. Hypoxia Stimulates Vesicular ATP Release From Rat Osteoblasts

    E-Print Network [OSTI]

    Burnstock, Geoffrey

    Hypoxia Stimulates Vesicular ATP Release From Rat Osteoblasts ISABEL R. ORRISS,1 GILLIAN E. KNIGHT, University of Surrey, Guildford, UK Many neuronal and non-neuronal cell types release ATP in a controlled manner. After release, extracellular ATP (or, following hydrolysis, ADP) acts on cells in a paracrine

  8. Single Glucose Biofuel Cells Implanted in Rats Power Electronic Devices

    E-Print Network [OSTI]

    Boyer, Edmond

    Single Glucose Biofuel Cells Implanted in Rats Power Electronic Devices A. Zebda1,2 , S. Cosnier1 the first implanted glucose biofuel cell (GBFC) that is capable of generating sufficient power from a mammal further developments. Following recent developments in nano- and biotechnology, state-of-the-art biofuel

  9. Susceptibility of immature rats to seizures induced by unsymmetrical dimethylhydrazine

    E-Print Network [OSTI]

    Boyd, Dale Duaine

    1963-01-01T23:59:59.000Z

    . Bain. Convulsant hydrazides I. In vito and in vivo inhibition of vitamin B6 enzymes by convulsive hydrazides. J. Pharmacol. Exp. Ther. 119:255-262 (1957). 8. Baxter, C. F. , and E. Roberts. Elevation of gamma-aminobutyric acid in rat brain...

  10. Original article Digestion and fermentation of proteins in rats fed

    E-Print Network [OSTI]

    Boyer, Edmond

    Original article Digestion and fermentation of proteins in rats fed keratin, albumin, cooked casein the hypothesis that cooking reduces the digestibility of casein, and increases the yield of bacterial me transfer and fermentation in the caecum. The caecal digestion of casein (cooked or not), ker- atin

  11. Facial Wiping in the Rat Fetus: Variation of Chemosensory

    E-Print Network [OSTI]

    Robinson, Scott R.

    how variation in stimulus parameters of lemon odor infusion (concentration, volume, and infusion time) affected the wiping response of E20 rat fetuses. Infusions of higher concentration or greater volume of stimulation. Intraoral infusion of chemosensory fluids with strong olfactory components, such as lemon extract

  12. Aardvark hunt in Kenya Gaten B. Rat}rUin

    E-Print Network [OSTI]

    I I i Aardvark hunt in Kenya Gaten B. Rat}rUin Dept of Omittrologr & Mamrnalogr, Catifomia Academy eactrirg science as a Peace Corps Volunteer at Mirogi $conOary Scnou in Sou*r Nyanza District or Kenya of Kenya in Nairobi. 14 #12;

  13. Characterization and Mapping of the Gene Conferring Resistance to Rift Valley Fever Virus Hepatic Disease in WF.LEW Rats

    E-Print Network [OSTI]

    Callicott, Ralph J.

    2010-01-14T23:59:59.000Z

    168 271 164 218 243 142 154 268 168 271 164 218 243 142 D6Rat46 D6Rat68 D6Rat105 D6Rat74 D6Rat144 D6Rat135 D6Rat124 D6Rat116 D6Rat1 155 278 246 253 185 169 260 152 238 155 278 244 255 181 169 260... 220 242 181 349 134 177 256 132 131 160 165 216 242 181 349 134 177 256 132 133 148 159 220 248 203 349 126 175 246 138 171 160 163 214 248 203 349 126 175 246 138 171 160 163 214 248 203 349...

  14. Hemodynamic characterization of chronic bile duct-ligated rats: effect of pentobarbital sodium

    SciTech Connect (OSTI)

    Lee, S.S.; Girod, C.; Braillon, A.; Hadengue, A.; Lebrec, D.

    1986-08-01T23:59:59.000Z

    Systemic and splanchnic hemodynamics of the chronic bile duct-ligated rat were characterized by radioactive microspheres. Conscious and pentobarbital sodium-anesthetized, bile duct-ligated and sham-operated rats had cardiac output and regional organ blood flows determined. The conscious bile duct-ligated rat compared with the sham-operated showed a hyperdynamic circulation with an increased cardiac output and portal tributary blood flow. Pentobarbital sodium anesthesia induced marked hemodynamic changes in both sham-operated and bile duct-ligated rats. The latter group was especially sensitive to its effects; thus, comparison of cardiac output and portal tributary blood flow between anesthetized bile duct-ligated and sham-operated rats showed no significant differences. The authors conclude that the rat with cirrhosis due to chronic bile duct ligation is an excellent model for hemodynamic investigations but should be studied in the conscious state, since pentobarbital sodium anesthesia eliminated the hyperdynamic circulation.

  15. Structural and thermoelectric properties of BaRCo{sub 4}O{sub 7} (R = Dy, Ho, Er, Tm, Yb, and Lu)

    SciTech Connect (OSTI)

    Wong-Ng, W.; Yan, Y.; Liu, G. [Ceramics Division, NIST, Gaithersburg, Maryland 20899 (United States); Xie, W.; Tritt, T. [Department of Physics, Clemson University, Greensville, South Carolina 29634 (United States); Kaduk, J. [Illinois Institute of Technology, Chicago, Illinois 60616 (United States); Thomas, E. [Air Force Research Laboratory, Wright Pattersen, Ohio 45433 (United States)

    2011-12-01T23:59:59.000Z

    The structure and thermoelectric properties of a series of barium lanthanide cobaltites, BaRCo{sub 4}O{sub 7} (R = Dy, Ho, Er, Tm, Yb, and Lu), which were prepared using the spark plasma synthesis technique, have been investigated. The space group of these compounds was re-determined and confirmed to be P31c instead of the reported P6{sub 3}mc. The lattice parameters a and c range from 6.26279(2) Angst to 6.31181(6) Angst , and from 10.22468(6) Angst to 10.24446(15) Angst for R = Lu to Dy, respectively. The crystal structure of BaRCo{sub 4}O{sub 7} is built up from Kagome sheets of CoO{sub 4} tetrahedra, linked by triangular layers of CoO{sub 4} tetrahedra. The values of figure of merit (ZT) of the BaRCo{sub 4}O{sub 7} samples were determined to be around 0.02 at 800 K. X-ray diffraction patterns of these samples have been determined and submitted to the Powder Diffraction File.

  16. Magnetic and dielectric behavior of the spin-chain compound Er{sub 2}BaNiO{sub 5} well below its Nel temperature

    SciTech Connect (OSTI)

    Basu, Tathamay; Singh, Kiran; Sampathkumaran, E. V. [Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400005 (India); Mohapatra, N. [School of Basic Sciences, Indian Institute of Technology Bhubaneshwar, Bhubaneshwar 751013 (India)

    2014-09-21T23:59:59.000Z

    We have recently reported that the Haldane spin-chain system, Er{sub 2}BaNiO{sub 5}, undergoing antiferromagnetic order below (T{sub N}=) 32?K, is characterized by the onset of ferroelectricity near 60?K due to magnetoelectric coupling induced by short-range magnetic-order within spin-chains. We have carried out additional magnetic and dielectric studies to understand the properties well below T{sub N}. We emphasize here on the following: (i) A strong frequency dependent behaviors of ac magnetic susceptibility and complex dielectric properties have been observed at much lower temperatures (<8?K), that is, reentrant multiglass-like phenomenon, naturally suggesting the existence of an additional transition well below T{sub N}. (ii) Magnetoelectric phase coexistence is observed at very low temperature (e.g., T?=?2?K), where the high-field magnetoelectric phase is partially arrested on returning to zero magnetic field after a cycling through metamagnetic transition.

  17. Origin of periodic domain structure in Er{sup 3+}-doped beta'-(Sm,Gd){sub 2}(MoO{sub 4}){sub 3} crystal lines patterned by laser irradiations in glasses

    SciTech Connect (OSTI)

    Suzuki, Futoshi; Honma, Tsuyoshi [Department of Materials Science and Technology, Nagaoka University of Technology, 1603-1 Kamitomioka-cho, Nagaoka 940-2188 (Japan); Komatsu, Takayuki, E-mail: komatsu@mst.nagaokaut.ac.j [Department of Materials Science and Technology, Nagaoka University of Technology, 1603-1 Kamitomioka-cho, Nagaoka 940-2188 (Japan)

    2010-04-15T23:59:59.000Z

    Er{sup 3+}-doped beta'-(Sm,Gd){sub 2}(MoO{sub 4}){sub 3} crystal lines are patterned on the surface of Er{sub 2}O{sub 3}-Gd{sub 2}O{sub 3}-Sm{sub 2}O{sub 3}-MoO{sub 3}-B{sub 2}O{sub 3} glasses by continuous-wave Yb:YVO{sub 4} laser irradiations (wavelength: 1080 nm, power: 1.3 W, scanning speeds: 5 {mu}m/s), and the origin of the periodicity of self-organized domain structures with high and low refractive index regions in crystal lines is examined from polarized optical microscope (POM) observations, micro-Raman scattering spectrum, and photoluminescence spectrum measurements. It is found that the periodicity of domain structures changes largely depending on Er{sub 2}O{sub 3} content, i.e., the length of high (bright color in POM observations) and low (dark color) refractive index regions increases with increasing Er{sub 2}O{sub 3} content and homogeneous crystal lines with no periodic domain structures are patterned in Er{sub 2}O{sub 3}-Sm{sub 2}O{sub 3}-MoO{sub 3}-B{sub 2}O{sub 3} glass with no Gd{sub 2}O{sub 3}. Considering that the degree of ferroelasticities in beta'-(Sm,Gd){sub 2}(MoO{sub 4}){sub 3} crystals decreases due to the incorporation of Er{sup 3+} ions, it is demonstrated that the origin of periodic domain structures in laser-patterned lines is due to spontaneous strains in ferroelastic beta'-(Sm,Gd){sub 2}(MoO{sub 4}){sub 3} crystals. - Graphical abstract: This figure shows the polarized optical photographs (top view) for the lines patterned by laser irradiations with the power of P=1.3 W and the scanning speed of S=5 {mu}m/s in xEr{sub 2}O{sub 3}-(18.25-x)Gd{sub 2}O{sub 3}-3Sm{sub 2}O{sub 3}-63.75MoO{sub 3}-15B{sub 2}O{sub 3} (mol%) glasses. This figure indicates that the periodicity of domain structures in beta'-(Sm,Gd){sub 2}(MoO{sub 4}){sub 3} crystal lines, i.e., the lengths of bright (high refractive index) and dark (low refractive index) color regions, changes depending on the amount of Er{sub 2}O{sub 3} addition. It is demonstrated that the origin of the periodicity of domain structures is due to spontaneous strains in ferroelastic beta'-(Sm,Gd){sub 2}(MoO{sub 4}){sub 3} crystals.

  18. Fine tunable red-green upconversion luminescence from glass ceramic containing 5%Er{sup 3+}:NaYF{sub 4} nanocrystals under excitation of two near infrared femtosecond lasers

    SciTech Connect (OSTI)

    Shang, Xiaoying; Cheng, Wenjing; Zhou, Kan; Ma, Jing; Feng, Donghai; Zhang, Shian; Sun, Zhenrong; Jia, Tianqing, E-mail: tqjia@phy.ecnu.edu.cn [State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai 200062 (China); Chen, Ping; Qiu, Jianrong [State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027 (China)

    2014-08-14T23:59:59.000Z

    In this paper, we report fine tunable red-green upconversion luminescence of glass ceramic containing 5%Er{sup 3+}: NaYF{sub 4} nanocrystals excited simultaneously by two near infrared femtosecond lasers. When the glass ceramic was irradiated by 800?nm femtosecond laser, weak red emission centered at 670?nm was detected. Bright red light was observed when the fs laser wavelength was tuned to 1490?nm. However, when excited by the two fs lasers simultaneously, the sample emitted bright green light centered at 550?nm, while the red light kept the same intensity. The dependences of the red and the green light intensities on the two pump lasers are much different, which enables us to manipulate the color emission by adjusting the two pump laser intensities, respectively. We present a theoretical model of Er{sup 3+} ions interacting with two fs laser fields, and explain well the experimental results.

  19. Upconversion and pump saturation mechanisms in Er{sup 3+}/Yb{sup 3+} co-doped Y{sub 2}Ti{sub 2}O{sub 7} nanocrystals

    SciTech Connect (OSTI)

    Wang, Fengxiao; Song, Feng, E-mail: fsong@nankai.edu.cn; Zhang, Gong; Han, Yingdong; Li, Qiong; Tian, Jianguo [School of Physics, Nankai University, Tianjin 300071 (China); The Key Laboratory of Weak Light Nonlinear Photonics, Ministry of Education, Nankai University, Tianjin 300457 (China); Ming, Chengguo [The Key Laboratory of Weak Light Nonlinear Photonics, Ministry of Education, Nankai University, Tianjin 300457 (China); Physics Department, School of Sciences, Tianjin University of Science and Technology, Tianjin 300457 (China)

    2014-04-07T23:59:59.000Z

    The Er{sup 3+}/Yb{sup 3+} co-doped Y{sub 2}Ti{sub 2}O{sub 7} nanocrystals were synthesized by the solgel method. X-ray diffraction, transmission electronic microscopy, and photoluminescence spectra were measured to verify the Y{sub 2}Ti{sub 2}O{sub 7} nanocrystalline produced in the sample annealed at 800?C. The anomalous slopes of the fitted line in the log-log plots for upconversion emissions and the pump-saturation effect of near-infrared emission were observed in the nanocrystalline samples. A theoretical model of practical Er{sup 3+}/Yb{sup 3+} co-doped system based on the rate equations were put forward and explained the experimental phenomena well.

  20. E-Print Network 3.0 - african mole rats Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    18 Trees of the "Madsen" data set Morphological topology Summary: Rat Capybara Rabbit Elephant Shrew Hedgehog Mole Sloth Opossum Kangaroo 12;Mitochondrial topology... Hedgehog...

  1. Brain reward deficits accompany withdrawal (hangover) from acute ethanol in rats

    E-Print Network [OSTI]

    Schulteis, Gery; Liu, Jian

    2006-01-01T23:59:59.000Z

    stimulation reward: effects of ethanol. Alcohol Clin Exp Resstimulus produced by ethanol withdrawal. J Pharmacol Expthe "anxiogenic" response to ethanol withdrawal in the rat.

  2. E-Print Network 3.0 - aged rat vocal Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Medicine 96 SOCIAL LEARNING IN NON-PRIMATE MAMMALS Bennett G. Galef Summary: , elephants, food choice, hamsters, mate choice, meekats, poison avoidance, predator avoidance, rats......

  3. E-Print Network 3.0 - adult rat prefrontal Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mem. Summary: of prefrontal neural activity in the rat to the acquisition of trace fear conditioning using microinfusions... was performed on a total of 120 adult male...

  4. E-Print Network 3.0 - alloxan-treated rats beneficial Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in a panel of 11 different inbred rat strains to evaluate the genetic variance Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo...

  5. E-Print Network 3.0 - adult rats neuroprotection Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    magnocellular nucleus basalis: neuroprotection by Ca(2... levels in rats: effects on brain 5-HT1A receptors and behavioral coping with stress in adult offspring... in adult...

  6. E-Print Network 3.0 - awake rats achieving Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    << < 1 2 3 4 5 > >> 1 Anticorrelated resting-state functional connectivity in awake rat brain Zhifeng Liang, Jean King, Nanyin Zhang Summary: Anticorrelated resting-state...

  7. Sorbitol accumulation in male and female rats consuming starch or fructose diets with or without copper

    SciTech Connect (OSTI)

    Lewis, C.G.; Fields, M.; Beal, T. (Dept. of Agriculture, Beltsville, MD (USA))

    1989-02-09T23:59:59.000Z

    The present study was designed to examine the relationship between the sex of the rats, tissue sorbitol accumulation and copper deficiency in rats consuming dietary fructose. Rats were provided with a diet containing either 62.7% fructose or starch, and either 6.0 or 0.6 {mu}g copper/g for three weeks. Hepatic copper concentration of all rats consuming the copper-deficient diets was about 40% of copper sufficient rats. Hepatic, renal and thymic sorbitol concentrations were significantly elevated in males consuming the fructose, copper-deficient diet when compared to all other dietary groups regardless of the sex of the rat. Hepatic, renal the thymic fructose concentrations were significantly higher in rats eating fructose as compared to female rats. Hepatic glucose concentration was higher in males and females consuming the fructose, copper-deficient diet when compared to all other dietary groups. Renal glucose concentration was elevated in males as compared to females. These results demonstrate that the pathology and complications of copper deficiency in the male rat consuming fructose closely parallel aberration in tissue sorbitol accumulation.

  8. PyRAT - python radiography analysis tool (u)

    SciTech Connect (OSTI)

    Temple, Brian A [Los Alamos National Laboratory; Buescher, Kevin L [Los Alamos National Laboratory; Armstrong, Jerawan C [Los Alamos National Laboratory

    2011-01-14T23:59:59.000Z

    PyRAT is a radiography analysis tool used to reconstruction images of unknown 1-0 objects. The tool is written in Python and developed for use on LINUX and Windows platforms. The tool is capable of performing nonlinear inversions of the images with minimal manual interaction in the optimization process. The tool utilizes the NOMAD mixed variable optimization tool to perform the optimization.

  9. Integrated transcriptomic and proteomic evaluation of gentamicin nephrotoxicity in rats

    SciTech Connect (OSTI)

    Com, Emmanuelle, E-mail: emmanuelle.com@univ-rennes1.fr [sanofi-aventis R and D, Disposition Safety and Animal Research, Vitry-sur-Seine (France) [sanofi-aventis R and D, Disposition Safety and Animal Research, Vitry-sur-Seine (France); INSERM U625, Proteomics Core Facility Biogenouest, Rennes (France); Boitier, Eric; Marchandeau, Jean-Pierre [sanofi-aventis R and D, Disposition Safety and Animal Research, Vitry-sur-Seine (France)] [sanofi-aventis R and D, Disposition Safety and Animal Research, Vitry-sur-Seine (France); Brandenburg, Arnd [Genedata AG, Basel (Switzerland)] [Genedata AG, Basel (Switzerland); Schroeder, Susanne [Nycomed GmbH, Barsbttel (Germany)] [Nycomed GmbH, Barsbttel (Germany); Hoffmann, Dana; Mally, Angela [University of Wrzburg, Department of Toxicology, University of Wrzburg, Wrzburg (Germany)] [University of Wrzburg, Department of Toxicology, University of Wrzburg, Wrzburg (Germany); Gautier, Jean-Charles [sanofi-aventis R and D, Disposition Safety and Animal Research, Vitry-sur-Seine (France)] [sanofi-aventis R and D, Disposition Safety and Animal Research, Vitry-sur-Seine (France)

    2012-01-01T23:59:59.000Z

    Gentamicin is an aminoglycoside antibiotic, which induces renal tubular necrosis in rats. In the context of the European InnoMed PredTox project, transcriptomic and proteomic studies were performed to provide new insights into the molecular mechanisms of gentamicin-induced nephrotoxicity. Male Wistar rats were treated with 25 and 75 mg/kg/day subcutaneously for 1, 3 and 14 days. Histopathology observations showed mild tubular degeneration/necrosis and regeneration and moderate mononuclear cell infiltrate after long-term treatment. Transcriptomic data indicated a strong treatment-related gene expression modulation in kidney and blood cells at the high dose after 14 days of treatment, with the regulation of 463 and 3241 genes, respectively. Of note, the induction of NF-kappa B pathway via the p38 MAPK cascade in the kidney, together with the activation of T-cell receptor signaling in blood cells were suggestive of inflammatory processes in relation with the recruitment of mononuclear cells in the kidney. Proteomic results showed a regulation of 163 proteins in kidney at the high dose after 14 days of treatment. These protein modulations were suggestive of a mitochondrial dysfunction with impairment of cellular energy production, induction of oxidative stress, an effect on protein biosynthesis and on cellular assembly and organization. Proteomic results also provided clues for potential nephrotoxicity biomarkers such as AGAT and PRBP4 which were strongly modulated in the kidney. Transcriptomic and proteomic data turned out to be complementary and their integration gave a more comprehensive insight into the putative mode of nephrotoxicity of gentamicin which was in accordance with histopathological findings. -- Highlights: ? Gentamicin induces renal tubular necrosis in rats. ? The mechanisms of gentamicin nephrotoxicity remain still elusive. ? Transcriptomic and proteomic analyses were performed to study this toxicity in rats. ? Transcriptomic and proteomic data turned out to be complementary and are integrated. ? A more comprehensive putative model of nephrotoxicity of gentamicin is presented.

  10. Analysis of Hydraulic Responses from the ER-6-1 Multiple-Well Aquifer Test, Yucca Flat FY 2004 Testing Program, Nevada Test Site, Nye County, Nevada, Rev. No.: 0

    SciTech Connect (OSTI)

    Greg Ruskauff

    2005-06-01T23:59:59.000Z

    This report documents the interpretation and analysis of the hydraulic data collected for the Fiscal Year (FY) 2004 Multiple-Well Aquifer Test-Tracer Test (MWAT-TT) conducted at the ER-6-1 Well Cluster in Yucca Flat Corrective Action Unit (CAU) 97, on the Nevada Test Site (NTS). The MWAT-TT was performed to investigate CAU-scale groundwater flow and transport processes related to the transport of radionuclides from sources on the NTS through the Lower Carbonate Aquifer (LCA) Hydrostratigraphic Unit (HSU). The ER-6-1 MWAT-TT was planned and executed by contractor participants for the Underground Test Area (UGTA) Project of the Environmental Restoration (ER) program of the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO). Participants included Stoller-Navarro Joint Venture (SNJV), the Environmental Engineering Services Contractor; Bechtel Nevada (BN); the Desert Research Institute (DRI); Los Alamos National Laboratory; and the University of Nevada, Las Vegas-Harry Reid Center. The SNJV team consists of the S.M. Stoller Corporation, Navarro Research and Engineering, Battelle Memorial Institute, INTERA Inc., and Weston Solutions, Inc. The MWAT-TT was implemented according to the ''Underground Test Area Project, ER-6-1 Multi-Well Aquifer Test - Tracer Test Plan'' (SNJV, 2004a) issued in April 2004. The objective of the aquifer test was to determine flow processes and local hydraulic properties for the LCA through long-term constant-rate pumping at the well cluster. This objective was to be achieved in conjunction with detailed sampling of the composite tracer breakthrough at the pumping well, as well as with depth-specific sampling and logging at multiple wells, to provide information for the depth-discrete analysis of formation hydraulic properties, particularly with regard to fracture properties.

  11. 891070-9932/142014IEEE sEptEmbEr 2014 IEEE rObOtICs & AUtOmAtION mAGAZINE By Yaroslav Tenzer, Leif P. Jentoft, and Robert D. Howe

    E-Print Network [OSTI]

    891070-9932/14©2014IEEE sEptEmbEr 2014 · IEEE rObOtICs & AUtOmAtION mAGAZINE · The Feel of MEMS available for a wide range of robotics and human-interface applications. Background Tactile sensing, such as the location of object contacts on the robot hand and contact pressure distribution, are believed

  12. Ag{sub 2}O dependent up-conversion luminescence properties in Tm{sup 3+}/Er{sup 3+}/Yb{sup 3+} co-doped oxyfluorogermanate glasses

    SciTech Connect (OSTI)

    Hu, Yuebo [Faculty of Mechanical and Electrical Engineering, Kunming University of Science and Technology, Kunming 650500 (China); Qiu, Jianbei, E-mail: qiu@kmust.edu.cn; Song, Zhiguo; Zhou, Dacheng [Key Laboratory of Advanced Materials in Rare and Precious and Non-ferrous Metals, Ministry of Education, Key Laboratory of Advanced Materials of Yunnan Province, Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093 (China)

    2014-02-28T23:59:59.000Z

    Up-conversion (UC) luminescence properties of Ag/Tm{sup 3+}/Er{sup 3+}/Yb{sup 3+} co-doped oxyfluorogermanate glasses have been studied to assess the effective role of silver nanoparticles as a sensitizer for Tm{sup 3+} and Er{sup 3+} ions. The X-ray diffraction patterns obtained in this work do not reveal any crystalline phase in the glass. However, the absorption spectra reveal that surface plasmons resonance band of Ag undergoes a distinct split with two maxima and a very broad absorption peak with a background that extends toward the near infrared (NIR) with the increasing of Ag{sub 2}O added concentration. Transmission electron microscope images confirm that silver nanoparticles have been precipitated from matrix glasses and show their distribution, size, and shapes. In addition, changes in UC luminescence intensity of four emission bands 476, 524, 546, and 658?nm corresponding to {sup 1}G{sub 4} ? {sup 3}H{sub 6} (Tm{sup 3+}), ({sup 2}H{sub 11/2}, {sup 4}S{sub 3/2}) ? {sup 4}I{sub 15/2} (Er{sup 3+}), and {sup 4}F{sub 9/2} ? {sup 4}I{sub 15/2} (Er{sup 3+}) transitions, respectively, as a function of silver addition to the base composition have been measured under 980?nm excitation. It is confirmed that Ag{sub 2}O added concentration plays an important role in increasing the UC luminescence intensity; however, further increase in Ag{sub 2}O added concentration reduces the intensity.

  13. Bifunction in Er{sup 3+}/Yb{sup 3+} co-doped BaTi{sub 2}O{sub 5}Gd{sub 2}O{sub 3} glasses prepared by aerodynamic levitation method

    SciTech Connect (OSTI)

    Zhang, Minghui [State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050 (China); University of Chinese Academy of Sciences, Beijing 100039 (China); Yu, Jianding; Pan, Xiuhong [State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050 (China); Cheng, Yuxing [State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050 (China); University of Chinese Academy of Sciences, Beijing 100039 (China); Liu, Yan, E-mail: liuyan@mail.sic.ac.cn [State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050 (China)

    2013-11-15T23:59:59.000Z

    Graphical abstract: - Highlights: Novel BaTi{sub 2}O{sub 5}Gd{sub 2}O{sub 3} based glasses have been prepared by aerodynamic levitation. The obtained glasses show high thermal stability with T{sub g} = 763.3 C. Er{sup 3+}/Yb{sup 3+} co-doped glasses show strong upconversion based on a two-photon process. Red emission is stronger than green emissions for EBT by high Yb{sup 3+} concentration. Magnetic ions are paramagnetic and the distribution is homogeneous in the glasses. - Abstract: Novel Er{sup 3+}/Yb{sup 3+} co-doped BaTi{sub 2}O{sub 5}Gd{sub 2}O{sub 3} spherical glasses have been fabricated by aerodynamic levitation method. The thermal stability, upconversion luminescence, and magnetic properties of the present glass have been studied. The glasses show high thermal stability with 763.3 C of the onset temperature of the glass transition. Red and green emissions centered at 671 nm, 548 nm and 535 nm are obtained at 980 nm excitation. The upconversion is based on a two-photon process by energy transfer, excited-state absorption, and energy back transfer. Yb{sup 3+} ions are more than Er{sup 3+} ions in the glass, resulting in efficient energy back transfer from Er{sup 3+} to Yb{sup 3+}. So the red emission is stronger than the green emissions. Magnetization curves indicate that magnetic rare earth ions are paramagnetic and the distribution is homogeneous and random in the glass matrix. Aerodynamic levitation method is an efficient way to prepare glasses with homogeneous rare earth ions.

  14. Influence of core size on the upconversion luminescence properties of spherical Gd{sub 2}O{sub 3}:Yb{sup 3+}/Er{sup 3+}@SiO{sub 2} particles with core-shell structures

    SciTech Connect (OSTI)

    Zheng, Kezhi; Liu, Zhenyu; Liu, Ye; Song, Weiye; Qin, Weiping, E-mail: wpqin@jlu.edu.cn [State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012 (China)

    2013-11-14T23:59:59.000Z

    Spherical SiO{sub 2} particles with different sizes (30, 80, 120, and 180?nm) have been coated with Gd{sub 2}O{sub 3}:Yb{sup 3+}/Er{sup 3+} layers by a heterogeneous precipitation method, leading to the formation of core-shell structural Gd{sub 2}O{sub 3}:Yb{sup 3+}/Er{sup 3+}@SiO{sub 2} particles. The samples were characterized by using X-ray diffraction, field emission scanning electron microscopy, transmission electron microscopy, upconversion (UC) emission spectra, and fluorescent dynamical analysis. The obtained core-shell particles have perfect spherical shape with narrow size distribution. Under the excitation of 980?nm diode laser, the core-shell samples showed size-dependent upconversion luminescence (UCL) properties. The inner SiO{sub 2} cores in core-shell samples were proved to have limited effect on the total UCL intensities of Er{sup 3+} ions. The UCL intensities of core-shell particles were demonstrated much higher than the values obtained in pure Gd{sub 2}O{sub 3}:Yb{sup 3+}/Er{sup 3+} with the same phosphor volume. The dependence of the specific area of a UCL shell on the size of its inner SiO{sub 2} particle was calculated and analyzed for the first time. It was confirmed that the surface effect came from the outer surfaces of emitting shells is dominant in influencing the UCL property in the core-shell samples. Three-photon UC processes for the green emissions were observed in the samples with small sizes of SiO{sub 2} cores. The results of dynamical analysis illustrated that more nonradiative relaxation occurred in the core-shell samples with smaller SiO{sub 2} core sizes.

  15. Bitumen fume-induced gene expression profile in rat lung

    SciTech Connect (OSTI)

    Gate, Laurent [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France)]. E-mail: laurent.gate@inrs.fr; Langlais, Cristina [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Micillino, Jean-Claude [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Nunge, Herve [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Bottin, Marie-Claire [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Wrobel, Richard [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Binet, Stephane [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France)

    2006-08-15T23:59:59.000Z

    Exposure to bitumen fumes during paving and roofing activities may represent an occupational health risk. To date, most of the studies performed on the biological effect of asphalt fumes have been done with regard to their content in carcinogenic polycyclic aromatic hydrocarbons (PAH). In order to gain an additional insight into the mechanisms of action of bitumen fumes, we studied their pulmonary effects in rodents following inhalation using the microarray technology. Fisher 344 rats were exposed for 5 days, 6 h/day to bitumen fumes generated at road paving temperature (170 {sup o}C) using a nose-only exposition device. With the intention of studying the early transcriptional events induced by asphalt fumes, lung tissues were collected immediately following exposure and gene expression profiles in control and exposed rats were determined by using oligonucleotide microarrays. Data analysis revealed that genes involved in lung inflammatory response as well as genes associated with PAH metabolization and detoxification were highly expressed in bitumen-exposed animals. In addition, the expression of genes related to elastase activity and its inhibition which are associated with emphysema was also modulated. More interestingly genes coding for monoamine oxidases A and B involved in the metabolism of neurotransmitters and xenobiotics were downregulated in exposed rats. Altogether, these data give additional information concerning the bitumen fumes biological effects and would allow to better review the health effects of occupational asphalt fumes exposure.

  16. Albumin extravasation rates in tissues of anesthetized and unanesthetized rats

    SciTech Connect (OSTI)

    Renkin, E.M.; Joyner, W.L.; Gustafson-Sgro, M.; Plopper, G.; Sibley, L.

    1989-05-01T23:59:59.000Z

    Bovine serum albumin (BSA) labeled with /sup 131/I was injected intravenously in chronically prepared, unanesthetized rats and into pentobarbital-anesthetized rats that had received 2 ml 5% BSA to help sustain plasma volume. Initial uptake rates (clearances) in skin, skeletal muscles, diaphragm, and heart (left ventricle) were measured over 1 h. BSA labeled with /sup 125/I was injected terminally to correct for intravascular /sup 131/I-BSA. Observed clearances were in the following order in both groups of animals: heart much greater than diaphragm approximately equal to skin greater than resting skeletal muscles. Differences between unanesthetized and anesthetized animals were small and inconsistently directed. Our results suggest that the lower albumin clearances reported in the literature for anesthetized rats are not the result of their immobility or any direct effect of anesthesia on albumin transport in these tissues. The lower transport rates appear to result indirectly from changes produced by anesthesia and/or surgery in controllable parameters such as plasma volume and intravascular protein mass.

  17. Impacts of the Norway Rat on the auklet breeding colony at Sirius Point, Kiska Island, Alaska in 2003

    E-Print Network [OSTI]

    Jones, Ian L.

    Impacts of the Norway Rat on the auklet breeding colony at Sirius Point, Kiska Island, Alaska of the Norway rat (Rattus norvegicus) onto Kiska Island, Aleutian Islands, Alaska, in the 1940s (Murie 1959 and to investigate the biology and demography of the Norway rat population. Moors and Atkinson (1984) suggested

  18. Auklet Demography and the Influence of Norway rats at Kiska Island report on results of monitoring to 2009

    E-Print Network [OSTI]

    Jones, Ian L.

    Auklet Demography and the Influence of Norway rats at Kiska Island ­ report on results METHODS 4 AUKLET PRODUCTIVITY 4 TIMING OF BREEDING 5 AUKLET SURVIVAL 6 NORWAY RAT ABUNDANCE 10 NORWAY RAT ABUNDANCE AND DISTRIBUTION 10 VEGETATION CHANGES 11 DISCUSSION 11 LEAST AUKLET

  19. Maternal Responsiveness to Infant Norway Rat (Rattus norvegicus) Ultrasonic Vocalizations During the Maternal Behavior Cycle and After

    E-Print Network [OSTI]

    Maternal Responsiveness to Infant Norway Rat (Rattus norvegicus) Ultrasonic Vocalizations During environment, Norway rat (Rattus norvegicus) pups emit ultrasonic vocalizations that can elicit maternal search is particularly important in altricial species such as the Norway rat in which infants rely on the mother

  20. ECOLOGY OF NORWAY RATS (RATTUS NORVEGICUS) IN RELATION TO CONSERVATION AND MANAGEMENT OF SEABIRDS ON KISKA ISLAND,

    E-Print Network [OSTI]

    Jones, Ian L.

    ECOLOGY OF NORWAY RATS (RATTUS NORVEGICUS) IN RELATION TO CONSERVATION AND MANAGEMENT OF SEABIRDS to predation by introduced Norway rats (Rattus norvegicus). In 2001 and 2002 the auklet colony experienced the lowest reproductive success ever recorded for auklets. Norway rats have been suggested as the cause

  1. pH dependence and compartmentalization of zinc transported across plasma membrane of rat cortical neurons

    E-Print Network [OSTI]

    pH dependence and compartmentalization of zinc transported across plasma membrane of rat corticalH dependence and compartmental- ization of zinc transported across plasma membrane of rat cortical neurons. Am; ion transport; transition elements; primary culture IT IS KNOWN THAT Zn2 can enter neurons by two

  2. Water balance in rats exposed to chronic centrifugation RUDY M. ORTIZ AND CHARLES E. WADE

    E-Print Network [OSTI]

    Ortiz, Rudy M.

    was observed, the lack of a change in %TBW among the three measurement periods or in water flux over the 12Water balance in rats exposed to chronic centrifugation RUDY M. ORTIZ AND CHARLES E. WADE Life; accepted in final form 22 February 2000 Ortiz, Rudy M., and Charles E. Wade. Water balance in rats exposed

  3. The impact of binge drinking on the young growing female rat skeleton

    E-Print Network [OSTI]

    Gallagher, Sharon Lee

    1997-01-01T23:59:59.000Z

    , on the actively growing skeleton. The objective of this study was to determine whether or not binge drinking impacts the normal growth process of the young growing female rat skeleton. Twelve, four-week-old, female rats were paired to form an ethanol group and a...

  4. DRD2 Gene Transfer Into the Nucleus Accumbens Core of the Alcohol Preferring and Nonpreferring Rats

    E-Print Network [OSTI]

    Homes, Christopher C.

    in alcohol intake in Sprague Dawley rats. This overexpression of DRD2 reduced alcohol consumption in a two that high levels of DRD2 are causally associated with a reduction in alcohol consumption and may serve Tomography (PET) Gene Therapy. ETHANOL STIMULATES BOTH dopamine (DA) neurons and DA release in the rat

  5. Research Report Effects of ethanol consumption by adult female rats on subsequent

    E-Print Network [OSTI]

    Galef Jr., Bennett G.

    Research Report Effects of ethanol consumption by adult female rats on subsequent consumption January 2004 Abstract We used a two-bottle choice test to measure voluntary ethanol consumption by adolescent rats that had lived with ethanol-consuming or water-consuming adult conspecifics. We found

  6. PMSG responsiveness during adult life after partial oogonia destruction with misulban in the rat embryo

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    sensitive to X-ray irradiation in the last period of division, i.e. about day 15 of pregnancy in the rat-month old female rats were bred under standard conditions of light (14 h light―10 h dark) and food

  7. MAGNESIUM ABSORPTION IN THE CCUM OF RATS RELATED TO VOLATILE FATTY ACIDS PRODUCTION

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    MAGNESIUM ABSORPTION IN THE C?CUM OF RATS RELATED TO VOLATILE FATTY ACIDS PRODUCTION Y. RAYSSIGUIER RELATIONS ENTRE L'ABSORPTION C,4ECALE DE MAGNESIUM CHEZ LE RAT ET LA PRODUCTION D'ACIDES GRAS VOLATILS du caecum, pH, acides gras volatils, activité microbienne. Introduction The mode of magnesium

  8. Plasticity in the Rat Posterior Auditory Field Following Nucleus Basalis Stimulation

    E-Print Network [OSTI]

    Kilgard, Michael P.

    Plasticity in the Rat Posterior Auditory Field Following Nucleus Basalis Stimulation Amanda C. Plasticity in the rat posterior auditory field following nucleus basalis stimulation. J Neurophysiol 98: 253 have been shown to cause frequency-specific plasticity in both primary and secondary cortical areas

  9. Activation of orexin signal in basal forebrain facilitates the emergence from sevoflurane anesthesia in rat

    E-Print Network [OSTI]

    anesthesia in rat Hailong Dong 1 , Jiyuan Niu 1 , Binxiao Su, Zhenghua Zhu, Yan Lv, Yizhi Li, Lize Xiong t Orexinergic system may play an important role in the regulation of anesthesiaarousal. However, which region, induction and emergence time to sevoflurane anesthesia in rats. Either orexin-A or orexin-B was injected

  10. Relaxation Time Constants and Apparent Diffusion Coefficients of Rat Retina at 7 Tesla

    E-Print Network [OSTI]

    Duong, Timothy Q.

    Relaxation Time Constants and Apparent Diffusion Coefficients of Rat Retina at 7 Tesla Govind Nair* and ADC of the rat eyes were measured at 50 3 50 3 800 lm at 7 Tesla. Profiles of T1, T2, T2* and ADC

  11. Catheterization of the Hepatic Artery Via the Left Common Carotid Artery in Rats

    SciTech Connect (OSTI)

    Li Xiao [West China Hospital, Sichuan University, Department of Radiology (China); Wang Yixiang, J. [AstraZeneca R and D (United Kingdom); Zhou Xiangping [West China Hospital, Sichuan University, Department of Radiology (China)], E-mail: xiangpingzhou46@163.com; Guan Yongsong; Tang Chengwei [West China Hospital, Sichuan University, Department of Gastroenterology (China)

    2006-12-15T23:59:59.000Z

    The commonly used approach for rat hepatic artery catheterization is via the gastroduodenal artery, which is ligated after the procedure. A new method of rat hepatic artery catheterization via the left common carotid artery (LCCA) is described. The LCCA is repaired after catheterization. The catheterization procedures included the following: (1) opening the rat's abdominal cavity and exposing the portion of abdominal aorta at the level of the celiac trunk; (2) separating and exposing the LCCA; inserting a microguidewire and microcatheter set into the LCCA via an incision; after placement into the descending aorta, the microguidewire and microcatheter are maneuvered into the hepatic artery under direct vision; (3) after transcatheter therapy, the catheter is withdrawn and the incision at the LCCA is repaired. This technique was employed on 60 male Sprague-Dawley rats with diethylnitrosamine-induced liver cancer, using a 3F microguidewire and microcatheter set. Selective hepatic artery catheterization was successfully performed in 57 rats. One rat died during the operation and five rats died within 7 days after the procedure. It is envisaged that as experience increases, the catheterization success rate will increase and the death rate will decrease. A new approach for selective hepatic artery catheterization via the LCCA in rats is introduced, which makes repeat catheterization of this artery possible and allows large embolization particles to be delivered by using a 3F catheter.

  12. Proteomic analysis of rat cerebral cortex following subchronic acrolein toxicity

    SciTech Connect (OSTI)

    Rashedinia, Marzieh; Lari, Parisa [Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad (Iran, Islamic Republic of); Abnous, Khalil, E-mail: Abnouskh@mums.ac.r [Pharmaceutical Research Center, Department of Medicinal Chemistry, Mashhad University of Medical Sciences, Mashhad (Iran, Islamic Republic of); Hosseinzadeh, Hossein, E-mail: Hosseinzadehh@mums.ac.ir [Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad (Iran, Islamic Republic of)

    2013-10-01T23:59:59.000Z

    Acrolein, a member of reactive ?,?-unsaturated aldehydes, is a major environmental pollutant. Acrolein is also produced endogenously as a toxic by-product of lipid peroxidation. Because of high reactivity, acrolein may mediate oxidative damages to cells and tissues. It has been shown to be involved in a wide variety of pathological states including pulmonary, atherosclerosis and neurodegenerative diseases. In this study we employed proteomics approach to investigate the effects of subchronic oral exposures to 3 mg/kg of acrolein on protein expression profile in the brain of rats. Moreover effects of acrolein on malondialdehyde (MDA) levels and reduced glutathione (GSH) content were investigated. Our results revealed that treatment with acrolein changed levels of several proteins in diverse physiological process including energy metabolism, cell communication and transport, response to stimulus and metabolic process. Interestingly, several differentially over-expressed proteins, including ?-synuclein, enolase and calcineurin, are known to be associated with human neurodegenerative diseases. Changes in the levels of some proteins were confirmed by Western blot. Moreover, acrolein increases the level of MDA, as a lipid peroxidation biomarker and decreased GSH concentrations, as a non-enzyme antioxidant in the brain of acrolein treated rats. These findings suggested that acrolein induces the oxidative stress and lipid peroxidation in the brain, and so that may contribute to the pathophysiology of neurological disorders. - Highlights: Acrolein intoxication increased lipid peroxidation and deplete GSH in rat brain. Effect of acrolein on protein levels of cerebral cortex was analyzed by 2DE-PAGE. Levels of a number of proteins with different biological functions were increased.

  13. Final Report for DOE Grant DE-FG02-03ER25579; Development of High-Order Accurate Interface Tracking Algorithms and Improved Constitutive Models for Problems in Continuum Mechanics with Applications to Jetting

    SciTech Connect (OSTI)

    Puckett, Elbridge Gerry [U.C. Davis, Department of Mathematics; Miller, Gregory Hale [.C. Davis, Department of Chemical Engineering

    2012-10-14T23:59:59.000Z

    Much of the work conducted under the auspices of DE-FG02-03ER25579 was characterized by an exceptionally close collaboration with researchers at the Lawrence Berkeley National Laboratory (LBNL). For example, Andy Nonaka, one of Professor Miller's graduate students in the Department of Applied Science at U. C. Davis (UCD) wrote his PhD thesis in an area of interest to researchers in the Applied Numerical Algorithms Group (ANAG), which is a part of the National Energy Research Supercomputer Center (NERSC) at LBNL. Dr. Nonaka collaborated closely with these researchers and subsequently published the results of this collaboration jointly with them, one article in a peer reviewed journal article and one paper in the proceedings of a conference. Dr. Nonaka is now a research scientist in the Center for Computational Sciences and Engineering (CCSE), which is also part of the National Energy Research Supercomputer Center (NERSC) at LBNL. This collaboration with researchers at LBNL also included having one of Professor Puckett's graduate students in the Graduate Group in Applied Mathematics (GGAM) at UCD, Sarah Williams, spend the summer working with Dr. Ann Almgren, who is a staff scientist in CCSE. As a result of this visit Sarah decided work on a problem suggested by the head of CCSE, Dr. John Bell, for her PhD thesis. Having finished all of the coursework and examinations required for a PhD, Sarah stayed at LBNL to work on her thesis under the guidance of Dr. Bell. Sarah finished her PhD thesis in June of 2007. Writing a PhD thesis while working at one of the University of California (UC) managed DOE laboratories is long established tradition at UC and Professor Puckett has always encouraged his students to consider doing this. Another one of Professor Puckett's graduate students in the GGAM at UCD, Christopher Algieri, was partially supported with funds from DE-FG02-03ER25579 while he wrote his MS thesis in which he analyzed and extended work originally published by Dr. Phillip Colella, the head of ANAG, and some of his colleagues. Chris Algieri is now employed as a staff member in Dr. Bill Collins' Climate Science Department in the Earth Sciences Division at LBNL working with computational models of climate change. Finally, it should be noted that the work conducted by Professor Puckett and his students Sarah Williams and Chris Algieri and described in this final report for DOE grant # DE-FC02-03ER25579 is closely related to work performed by Professor Puckett and his students under the auspices of Professor Puckett's DOE SciDAC grant DE-FC02-01ER25473 An Algorithmic and Software Framework for Applied Partial Differential Equations: A DOE SciDAC Integrated Software Infrastructure Center (ISIC). Dr. Colella was the lead PI for this SciDAC grant, which was comprised of several research groups from DOE national laboratories and five university PI's from five different universities. In theory Professor Puckett tried to use funds from the SciDAC grant to support work directly involved in implementing algorithms developed by members of his research group at UCD as software that might be of use to Puckett's SciDAC CoPIs. (For example, see the work reported in Section 2.2.2 of this final report.) However, since there is considerable lead time spent developing such algorithms before they are ready to become `software' and research plans and goals change as the research progresses, Professor Puckett supported each member of his research group partially with funds from the SciDAC APDEC ISIC DE-FC02-01ER25473 and partially with funds from this DOE MICS grant DE-FC02-03ER25579. This has necessarily resulted in a significant overlap of project areas that were funded by both grants. In particular, both Sarah Williams and Chris Algieri were supported partially with funds from grant # DE-FG02-03ER25579, for which this is the final report, and in part with funds from Professor Puckett's DOE SciDAC grant # DE-FC02-01ER25473. For example, Sarah Williams received support from DE-FC02- 01ER25473 and DE-FC02-03ER25579, both while at UCD taking cla

  14. miller-er-99.PDF

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched5 Industrial Carbon CaptureFY08 Joint JOULE J. NoremI Prepared by. .,Analysis of

  15. The oncogenic action of ionizing radiation on rat skin

    SciTech Connect (OSTI)

    Burns, F.J.; Garte, S.J.

    1992-01-01T23:59:59.000Z

    The multistage theory of carcinogenesis specifies that cells progress to cancer through a series of discrete, irreversible genetic alterations, but data on radiation-induced cancer incidence in rat skin suggests that an intermediate repairable alteration may occur. Data are presented on cancer induction in rat skin exposed to an electron beam (LET=0.34 keV/[mu]), a neon ion beam (LET=45) or an argon ion beam (LET=125). The rats were observed for tumors at least 78 weeks with squamous and basal cell carcinomas observed. The total cancer yield was fitted by the quadratic equation, and the equation parameters were estimated by linear regression for each type of radiation. Analysis of the DNA from the electron-induced carcinomas indicated that K-ras and/or c-myc oncogenes were activated. In situ hybridization indicated that the cancers contain subpopulations of cells with differing amounts of c-myc and H-ras amplification. The results are consistent with the idea that ionizing radiation produces stable, carcinogenically relevant lesions via 2 repairable events at low LET and via a non-repairable linked event pathway at high LET; either pathway may advance the cell by 1 stage. The proliferative response of rat epidermis following exposure to ionizing radiation was quantified by injection of [sup 14]C-thymidine. The return of these cells to S-phase a second time was detected by a second label ([sup 3]H). When the labeled cells were in G1-phase, the dorsal skin was irradiated with X-rays. All labeling indices were determined. The [sup 14]C labeling index was constant and unaffected by the radiation. The proportion of all cells entering S-phase averaged 3.5% at 18 hr and increased after 44, 52 and 75 hr to average levels of 11.8%, 5. 3%, and 6.6% at 0, 10 and 25 Gy respectively. The proportion of S-phase cells labeled with [sup 14]C increased after 42 hr and remained relatively constant thereafter.

  16. Organization and evolution of the rat tyrosine hydroxylase gene

    SciTech Connect (OSTI)

    Brown, E.R.; Coker, G.T. III; O'Malley, K.L.

    1987-08-11T23:59:59.000Z

    This report describes the organization of the rat tyrosine hydroxylase (TH) gene and compares its structure with the human phenylalanine hydroxylase gene. Both genes are single copy and contain 13 exons separated by 12 introns. Remarkably, the positions of 10 out 12 intron/exon boundaries are identical for the two genes. These results support the idea that these hydroxylases genes are members of a gene family which has a common evolutionary origin. The authors predict that this ancestral gene would have encoded exons similar to those of TH prior to evolutionary drift to other members of this gene family.

  17. Final Technical Report "Catalytic Hydrogenation of Carbon Monoxide and Olefin Oxidation" Grant number : DE-FG02-86ER13615

    SciTech Connect (OSTI)

    Wayland, B.B.

    2009-08-31T23:59:59.000Z

    Title: Catalytic Hydrogenation of Carbon Monoxide and Olefin Oxidation Grant No. DE-FG02-86ER13615 PI: Wayland, B. B. (wayland@sas.upenn.edu) Abstract Development of new mechanistic strategies and catalyst materials for activation of CO, H2, CH4, C2H4, O2, and related substrates relevant to the conversion of carbon monoxide, alkanes, and alkenes to organic oxygenates are central objectives encompassed by this program. Design and synthesis of metal complexes that manifest reactivity patterns associated with potential pathways for the hydrogenation of carbon monoxide through metallo-formyl (M-CHO), dimetal ketone (M-C(O)-M), and dimetal dionyl (M-C(O)-C(O)-M) species is one major focus. Hydrocarbon oxidation using molecular oxygen is a central goal for methane activation and functionalization as well as regioselective oxidation of olefins. Discovery of new reactivity patterns and control of selectivity are pursued through designing new metal complexes and adjusting reaction conditions. Variation of reaction media promotes distinct reaction pathways that control both reaction rates and selectivities. Dimetalloradical diporphyrin complexes preorganize transition states for substrate reactions that involve two metal centers and manifest large rate increases over mono-metalloradical reactions of hydrogen, methane, and other small molecule substrates. Another broad goal and recurring theme of this program is to contribute to the thermodynamic database for a wide scope of organo-metal transformations in a range of reaction media. One of the most complete descriptions of equilibrium thermodynamics for organometallic reactions in water and methanol is emerging from the study of rhodium porphyrin substrate reactions in aqueous and alcoholic media. Water soluble group nine metalloporphyrins manifest remarkably versatile substrate reactivity in aqueous and alcoholic media which includes producing rhodium formyl (Rh-CHO) and hydroxy methyl (Rh-CH2OH) species. Exploratory directions for this program include expending new strategies for anti-Markovnikov addition of water, alcohols, and amines with olefins, developing catalytic reactions of CO to give formamides and formic esters, and evaluating the potential for coupling reactions of CO to produce organic building blocks.

  18. Sodium alterations in isolated rat heart during cardioplegic arrest

    SciTech Connect (OSTI)

    Schepkin, V.D.; Choy, I.O.; Budinger, T.F. [Lawrence Berkeley National Lab., CA (United States)

    1996-12-01T23:59:59.000Z

    Triple-quantum-filtered (TQF) Na nuclear magnetic resonance (NMR) without chemical shift reagent is used to investigate Na derangement in isolated crystalloid perfused rat hearts during St. Thomas cardioplegic (CP) arrest. The extracellular Na contribution to the NMR TQF signal of a rat heart is found to be 73 {+-} 5%, as determined by wash-out experiments at different moments of ischemia and reperfusion. With the use of this contribution factor, the estimated intracellular Na ([Na{sup +}]{sub i}) TQF signal is 222 {+-} 13% of preischemic level after 40 min of CP arrest and 30 min of reperfusion, and the heart rate pressure product recovery is 71 {+-} 8%. These parameters are significantly better than for stop-flow ischemia: 340 {+-} 20% and 6 {+-} 3%, respectively. At 37{degrees}C, the initial delay of 15 min in [Na{sup +}]{sub i} growth occurs during CP arrest along with reduced growth later ({approximately}4.0%/min) in comparison with stop-flow ischemia ({approximately}6.7%/min). The hypothermia (21{degrees}C, 40 min) for the stop-flow ischemia and CP dramatically decreases the [Na{sup +}]{sub i} gain with the highest heart recovery for CP ({approximately}100%). These studies confirm the enhanced sensitivity of TQF NMR to [Na{sup +}]{sub i} and demonstrate the potential of NMR without chemical shift reagent to monitor [Na{sup +}]{sub i} derangements. 48 refs., 7 figs., 1 tab.

  19. Effect of anesthesia on glucose production and utilization in rats

    SciTech Connect (OSTI)

    Penicaud, L.; Ferre, P.; Kande, J.; Leturque, A.; Issad, T.; Girard, J.

    1987-03-01T23:59:59.000Z

    This study was undertaken to determine the effects of pentobarbital anesthesia (50 mg/kg ip) on glucose kinetics and individual tissue glucose utilization in vivo, in chronically catheterized rats. Glucose turnover studies were carried out using (3-/sup 3/H) glucose as tracer. A transient hyperglycemia and an increased glucose production were observed 3 min after induction of anesthesia. However, 40 min after induction of anesthesia, glycemia returned to the level observed in awake animals, whereas glucose turnover was decreased by 30% as compared with unanesthetized rats. These results are discussed with regard to the variations observed in plasma insulin, glucagon, and catecholamine levels. Glucose utilization by individual tissues was studied by the 2-(1-/sup 3/H) deoxyglucose technique. A four- to fivefold decrease in glucose utilization was observed in postural muscles (soleus and adductor longus), while in other nonpostural muscles (epitrochlearis, tibialis anterior, extensor digitorum longus, and diaphragm) and other tissues (white and brown adipose tissues) anesthesia did not modify the rate of glucose utilization. A decrease in glucose utilization was also observed in the brain.

  20. Luminescence properties of light-emitting diodes based on GaAs with the up-conversion Y{sub 2}O{sub 2}S:Er,Yb luminophor

    SciTech Connect (OSTI)

    Gruzintsev, A. N., E-mail: gran@ipmt-hpm.ac.ru [Russian Academy of Sciences, Institute of Problems of Microelectronics Technology (Russian Federation); Barthou, C.; Benalloul, P. [Institute des NanoSciences (France)

    2008-03-15T23:59:59.000Z

    Y{sub 2}O{sub 2}S luminophors doped with Er{sup 3+} and Yb{sup 3+} ions are produced by means of solid-phase synthesis and deposited onto standard AL123A infrared light-emitting diodes. When excited with 940 nm radiation from a light-emitting diode, the structures exhibit intense visible up-conversion luminescence. A maximal brightness of 2340 cd/m{sup 2} of green and red up-conversion luminescence at corresponding wavelengths around 550 and 600 nm is observed for the Y{sub 2}O{sub 2}S compound doped with 2 at % Er{sup 3+} ions and 6 at % Yb{sup 3+} ions. The ratio of the intensity of green (or red) up-conversion luminescence to the intensity of infrared Stokes luminescence increases with increasing applied voltage. The efficiency of visible emission of the light-emitting diode structures is {eta} = 1.2 lm/W at an applied voltage of 1.5 V.

  1. E-Print Network 3.0 - anesthetized lactating rats Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in situ and force in the rat plantaris muscle during repeated Effect of lactate infusion on M... .physiology.orgDownloadedfrom 12;Effect of lactate infusion on M-wave...

  2. E-Print Network 3.0 - alpha-macroglobulin rat alpha Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    hormones such as ACTH, corticosterone, cytokines of IL-1beta, IL-6, and TNF-alpha in CIA rats were... .4. Diurnal variations of IL-1beta, TNF-alpha and IL-6 In our study, serum...

  3. E-Print Network 3.0 - adult rat left Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Norway rats born to a colony whose adults had learned to avoid ingesting a particular poison... bait would not eat that bait. He hypothesized that adult ... Source: Galef Jr.,...

  4. E-Print Network 3.0 - adult wistar rats Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (C3H RIII)F1... 344Tox fdr FDRL fds Food and Drug Research Laboratories stock rats fis Fischer fmf Fischer 344Mai f... :(LE) lee Leeds albino lev Long-Evans lew Lewis lwj...

  5. E-Print Network 3.0 - albinus rat wistar Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (C3H RIII)F1... 344Tox fdr FDRL fds Food and Drug Research Laboratories stock rats fis Fischer fmf Fischer 344Mai f... :(LE) lee Leeds albino lev Long-Evans lew Lewis lwj...

  6. E-Print Network 3.0 - adult rat heart Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    heart Search Powered by Explorit Topic List Advanced Search Sample search results for: adult rat heart Page: << < 1 2 3 4 5 > >> 1 doi:10.1152ajpheart.00114.2006 291:496-506,...

  7. E-Print Network 3.0 - acetate-salt hypertensive rats Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    hypertensive rats Page: << < 1 2 3 4 5 > >> 1 ISSN: 1524-4563 Copyright 2005 American Heart Association. All rights reserved. Print ISSN: 0194-911X. Online Summary: hypertensive...

  8. E-Print Network 3.0 - adult rats spinalized Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Search Sample search results for: adult rats spinalized Page: << < 1 2 3 4 5 > >> 1 Brain Research 918 (2001) 101106 www.elsevier.comlocatebres Summary: play a minor role in...

  9. E-Print Network 3.0 - adult rat spinal Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Advanced Search Sample search results for: adult rat spinal Page: << < 1 2 3 4 5 > >> 1 Brain Research 918 (2001) 101106 www.elsevier.comlocatebres Summary: play a minor role in...

  10. The effect of Zoledronate treatment timing on lumbar and caudal vertebrae in ovariectomized rats

    E-Print Network [OSTI]

    Ruchelsman, Michal (Michal Aliza)

    2007-01-01T23:59:59.000Z

    Introduction: While there have been numerous studies demonstrating the effect of bisphosphonates in rats as either a preventative treatment or recovering treatment for osteoporosis, few have directly compared the two ...

  11. The Lower Keys marsh rabbit and silver rice rat: steps toward recovery

    E-Print Network [OSTI]

    Perry, Neil Desmond

    2006-10-30T23:59:59.000Z

    be detrimentally impacted by hardwood encroachment into salt-marsh habitats. For LKMR recovery, I recommend management to resist hardwood encroachment, together with active predator control. I surveyed 36 locations on 18 islands for SRRs, capturing rats on 12...

  12. E-Print Network 3.0 - adult rat sacral Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    capensis) from Cape Town. Used with the permission of the pho... . Georychus capensis (Pallas, 1778) Cape Mole-rat Mus capensis Pallas, 1778:172. Type locality ... Source: Hayssen,...

  13. Effects of insulin on messenger RNA activities in rat liver

    SciTech Connect (OSTI)

    Hill, R.E. (Univ. of Tennessee, Oak Ridge); Lee, K.L.; Kenney, F.T.

    1981-02-25T23:59:59.000Z

    Liver poly(A) RNA, isolated from adrenalectomized rats after insulin treatment, was translated in a nuclease-treated lysate of rabbit reticulocytes and quantitated for both total activity and the capacity to synthesize the insulin-inducible enzyme tyrosine amino-transferase. Analysis of the translated products from poly(A) RNA isolated 1 h after insulin treatment showed a 2.7-fold increase in activity of tyrosine aminotransferase mRNA. During the same interval, the capacity of poly(A) RNA to direct the synthesis of total protein in lysates also changed, showing a 30 to 40% increase in translational activity/unit of RNA. Increased translatability was apparent in all fractions of poly(A) RNA separated by centrifugation on sucrose gradients. Insulin thus appears to mediated a generalized changed in mRNAs leading to increased capacity for translation; induction of tyrosine aminotransferase may reflect unusual sensitivity to this effect of the hormone.

  14. The effects of radiation on spermatogenesis in the albino rat as determined by semen analysis

    E-Print Network [OSTI]

    Lawson, Rommon Loy

    1964-01-01T23:59:59.000Z

    rate all could be significant factors. Total body X-irradiation (470 r) in rats produced minimal alterations in the testes, namely depletion of spermatogonia (Gunn, et al. , 1960). 17 18 The effect of whole-body radiation on fertility of male rats...) Figure 22. Effect of Radiation on Weight Change (Chronic). no irradiation, demonstrated steady weekly increases through the investigation period. The average body weight of these animals at the initiation of this study was approximately 510 grams...

  15. Sodium and potassium levels in the serum of acutely irradiated and non-irradiated rats

    E-Print Network [OSTI]

    Shepherd, David Preston

    1967-01-01T23:59:59.000Z

    SODIUM AND POTASSIUM LEVELS IN THE SERUM OF ACUTELY IRRADIATED AND NON-IRRADIATED RATS A Thesis By DAVID PRESTON SHEPHERD Submitted to the Graduate College of the Texas ARM University in partial fulfillment of the requirements for the degree... of MASTER OF SCIENCE August 1967 Major Subject: Zoology SODIUM AND POTASSIUM LEVELS IN THE SERUM OF ACUTELY IRRADIATED AND NON-IRRADIATED RATS A Thesis By DAVID PRESTON SHEPHERD Approved as to style and content by: (Chairman of Committee) (Head...

  16. Copper induced osteopenia and its relationship to the development of postmenopausal osteoporosis in the rat

    E-Print Network [OSTI]

    Yee, Cindy Deann

    1992-01-01T23:59:59.000Z

    COPPER INDUCED OSTEOPENIA AND ITS RELATIONSHIP TO THE DEVELOPMENT OF POSTMENOPAUSAL OSTEOPOROSIS IN THE RAT A Thesis CINDY DEANN YEE Submitted to the Office of Graduate Studies of Texas ASM University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE August 1992 Major Subject: Nutrition COPPER INDUCED OSTEOPENIA AND ITS RELATIONSHIP TO THE DEVELOPMENT OF POSTMENOPAUSAL OSTEOPOROSIS IN THE RAT A Thesis CINDY DEANN YEE Approved as to style and content...

  17. Tissue magnesium and calcium concentration in relation to magnesium and calcium intake in rats

    E-Print Network [OSTI]

    Pinkham, Carrie Stanton

    2012-06-07T23:59:59.000Z

    TISSUE MAGNESIUM AND CALCIUM CONCENTRATION IN RELATION TO MAGNESIUM AND CALCIUM INTAKE IN RATS A Thesis by CARRIE STANTON PINKRAM Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirerrents... for the degree of MASTER OF SCIENCE August 1987 Major Subject: Nutrition TISSUE MAGNESIUM AND CALCIUM CONCENTRATION IN RELATION TO MAGNESIUM AND CALCIUM INTAKE IN RATS A Thesis by CARRIE STANTON PINKHAM Approved as to style and content by: Karen S...

  18. Magnesium and pyridoxine intake and mineral content of selected tissues and physical development in rats

    E-Print Network [OSTI]

    Edgar, Susan Elaine

    2012-06-07T23:59:59.000Z

    MAGNESIUM AND PYRIDOXINE INTAKE MINERAL CONTENT OF SELECTED TISSUES PHYSICAL DEVELOPMENT IN RATS A Thesis by SU S AN ELA I NE EDGAR Submitted to the Graduate College of Texas A8rM University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE August 1986 Major Subject: Nutrition MAGNESIUM AND PYRIDOXINE INTAKE MINERAL CONTENT OF SELECTED TISSUES PHYS ICAL DEVELOPMENT IN RATS A Thesis by SUSAN ELAINE EDGAR Approved as to style and content by: 'KAREN...

  19. LES TYROSINASES CUTANES CHEZ LE RAT. MODIFICATIONS AU COURS DU DVELOPPEMENT

    E-Print Network [OSTI]

    Boyer, Edmond

    LES TYROSINASES CUTAN?ES CHEZ LE RAT. MODIFICATIONS AU COURS DU D?VELOPPEMENT ET PENDANT LE CYCLE Sciences appliquées, 69621 Villeurbanne 1 1 R?SUM? Nous avons effectué l'étude des tyrosinases de la peau chez le Rat. Ces tyrosinases sont mises en évidence, après électrophorèse par réaction de Dopa sur gel

  20. Prolactin and aging: X-irradiated and estrogen-induced rat mammary tumorigenesis

    SciTech Connect (OSTI)

    Ito, A.; Naito, M.; Watanabe, H.; Yokoro, K.

    1984-07-01T23:59:59.000Z

    Both sexes of inbred WF rats at either 8 or 28-60 weeks of age were exposed to 200 rad whole-body radiation, 2.5 or 5.0 mg 17 beta-estradiol (E2), or both agents The female rats treated with E2 alone or with both X-rays and E2 at 8 weeks of age showed a high incidence of mammary carcinomas (MCA), a large increase in pituitary weight, and a rise in serum prolactin (PRL) levels. However, the same treatments to males did not induce MCA despite a moderate increase in both pituitary weight and serum PRL. Ovariectomy prior to E2 treatment failed to modify the occurrence of MCA or pituitary tumors. When X-rays and E2 were given to female rats at 28-60 weeks of age, pituitary weight, serum PRL levels, and the incidence of MCA were unaffected. When the E2 pellet was kept for the first 24 weeks and withdrawn during the last 12 weeks, the incidence of MCA, pituitary weight, and serum PRL was low. It was concluded that: 1) the pituitary glands of young female rats were susceptible to E2 treatment but were insensitive in older females, and 2) the occurrence of MCA in female rats appeared to be promoted by elevated PRL levels secreted by E2-induced pituitary tumors. Mammary tissue of male rats was less sensitive to PRL levels in the development of MCA.

  1. Ovariectomized Sprague-Dawley and Long-Evans rats release prolactin differently in response to estrogen

    SciTech Connect (OSTI)

    Lawson, D.M.; Sensui, N.; Gala, R.R.

    1984-01-30T23:59:59.000Z

    Mature female Sprague-Dawley (SD) and Long-Evans (LE) rats were ovariectomized (OVX), and given a single sc injection of either 25 or 100 ..mu..g polyestradiol phosphate (PEP); seven days later blood samples were withdrawn at two hour intervals from 1100 to 2100 hours to detect the presence of an afternoon surge of prolactin (PRL). Other groups of OVX rats of both strains also treated with PEP were sampled before and at 2, 5, 10 and 30 min after iv administration of 1 ..mu..g synthetic thyrotropin releasing hormone (TRH). Pituitary (AP) and uterine weights were determined following sacrifice one day after TRH treatment. The AP homogenates and plasma samples were assayed for PRL by radioimmunoassay. Rats of both strains had afternoon PRL surges and in both strains the magnitude and/or duration of the surges were enhanced by the higher dose of PEP. However, within each PEP dose LE rats released significantly more PRL during the surge than did SD drats. Rats of both strains also rleased PRL in response to TRH and this response was enhanced in both strains by the higher of the two doses of PEP. These data not only show that strain differences exist in estrogen-induced or mediated PRL release in the rat but also indicate that the differences are not uniform.

  2. Anti-inflammatory activity of methyl palmitate and ethyl palmitate in different experimental rat models

    SciTech Connect (OSTI)

    Saeed, Noha M. [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo (Egypt)] [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo (Egypt); El-Demerdash, Ebtehal [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt)] [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt); Abdel-Rahman, Hanaa M. [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo (Egypt)] [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo (Egypt); Algandaby, Mardi M. [Department of Biology (Botany), Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia)] [Department of Biology (Botany), Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia); Al-Abbasi, Fahad A. [Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia)] [Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia); Abdel-Naim, Ashraf B., E-mail: abnaim@pharma.asu.edu.eg [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt)

    2012-10-01T23:59:59.000Z

    Methyl palmitate (MP) and ethyl palmitate (EP) are naturally occurring fatty acid esters reported as inflammatory cell inhibitors. In the current study, the potential anti-inflammatory activity of MP and EP was evaluated in different experimental rat models. Results showed that MP and EP caused reduction of carrageenan-induced rat paw edema in addition to diminishing prostaglandin E2 (PGE2) level in the inflammatory exudates. In lipopolysaccharide (LPS)-induced endotoxemia in rats, MP and EP reduced plasma levels of tumor necrosis factor-? (TNF-?) and interleukin-6 (IL-6). MP and EP decreased NF-?B expression in liver and lung tissues and ameliorated histopathological changes caused by LPS. Topical application of MP and EP reduced ear edema induced by croton oil in rats. In the same animal model, MP and EP reduced neutrophil infiltration, as indicated by decreased myeloperoxidase (MPO) activity. In conclusion, this study demonstrates the effectiveness of MP and EP in combating inflammation in several experimental models. -- Highlights: ? Efficacy of MP and EP in combating inflammation was displayed in several models. ? MP and EP reduced carrageenan-induced rat paw edema and prostaglandin E2 level. ? MP and EP decreased TNF-? and IL-6 levels in experimental endotoxemia. ? MP and EP reduced NF-?B expression and histological changes in rat liver and lung. ? MP and EP reduced croton oil-induced ear edema and neutrophil infiltration.

  3. Dose-Response Effect of Charged Carbon Beam on Normal Rat Retina Assessed by Electroretinography

    SciTech Connect (OSTI)

    Mizota, Atsushi, E-mail: mizota-a@med.teikyo-u.ac.j [Department of Ophthalmology, Teikyo University School of Medicine, Tokyo (Japan); Department of Ophthalmology, Juntendo University Urayasu Hospital, Urayasu (Japan); Tanaka, Minoru [Department of Ophthalmology, Juntendo University Urayasu Hospital, Urayasu (Japan); Kubota, Mariko; Negishi, Hisanari [Department of Ophthalmology, National Hospital Organization Chiba Medical Center, Chiba (Japan); Watanabe, Emiko [Department of Ophthalmology, Teikyo University School of Medicine, Tokyo (Japan); Tsuji, Hiroshi; Miyahara, Nobuyuki; Furusawa, Yoshiya [National Institute of Radiological Sciences, Chiba (Japan)

    2010-12-01T23:59:59.000Z

    Purpose: To compare the effects of carbon beam irradiation with those of proton beam irradiation on the physiology of the retina of rats. Methods and Materials: Eight-week-old Wister rats were used. The right eyes were irradiated with carbon beam (1, 2, 4, 8, and 16 Gy) or proton beam (4, 8, 16, and 24 Gy) with the rats under general anesthesia. Electroretinograms were recorded 1, 3, 6, and 12 months after the irradiation, and the amplitudes of the a and b waves were compared with those of control rats. Results: The amplitude of b waves was reduced more than that of a waves at lower irradiation doses with both types of irradiation. With carbon ion irradiation, the amplitudes of the b wave were significantly reduced after radiation doses of 8 and 16 Gy at 6 months and by radiation doses of 4, 8, and 16 Gy at 12 months. With proton beam irradiation, the b-wave amplitudes were significantly reduced after 16 and 24 Gy at 6 months and with doses of 8 Gy or greater at 12 months. For the maximum b-wave amplitude, a significant difference was observed in rats irradiated with carbon beams of 4 Gy or more and with proton beams of 8 Gy or more at 12 months after irradiation. Conclusions: These results indicate that carbon beam irradiation is about two times more damaging than proton beam irradiation on the rat retina at the same dose.

  4. S I M O N F RASE R U N I V ERS I T Y E N V I R O N M E N T A L H E A L T H & S A F E T Y

    E-Print Network [OSTI]

    S I M O N F RASE R U N I V ERS I T Y E N V I R O N M E N T A L H E A L T H & S A F E T Y Rodent the Plan. The plan was last updated on April 22, 2009. #12;S I M O N F RASE R U N I V ERS I T Y E N V I R O N M E N T A L H E A L T H & S A F E T Y EHS April 22, 2009 3/10 Table of Contents 1 INTRODUCTION

  5. The effects of exercise and dietary fat on calcium, magnesium, iron, and zinc on selected tissues in rats

    E-Print Network [OSTI]

    Nguyen, Thuy Huong

    1989-01-01T23:59:59.000Z

    and had a 12-hour photoperiod. Cages were lined with woodchip bedding, and stainless steel feeders were used. Design Following a three-day acclimation period, during which rats were fed the control diet, the rats were weighed and randomly assigned... the reliability of exhaustive swimming in the laboratory rat. Male albino rats exhibited exercise oxygen consumption of 2. 7 times the resting level in a no-weight applied condition after swimming for 5 to 30 minutes. At a load of 2% body weight, oxygen...

  6. Differences in pulmonary responses of rats, other animals, and humans to chronic inhalation of silica and other particles

    SciTech Connect (OSTI)

    Mauderly, J.L.

    1993-12-31T23:59:59.000Z

    The pulmonary carcinogenicity of quartz in rats supports the plausibility of silica-induced lung cancer in humans. However, pulmonary responses of rats to dusts differ from those of other rodents, and may differ from those of humans. Dust-exposed rats have a greater propensity than mice or hamsters for epithelial hyperplasia, metaplasia, and fibrosis. Lung tumors occur in rats, but not mice or hamsters, treated with quartz, or exposed chronically to several other dusts. There are few opportunities for directly comparing the susceptibilities of rats and humans to dust-induced lung tumors. Because of the uncertain human responses to silica and many other particles, the negative human lung cancer response to coal dust may provide the best opportunity to calibrate responses of rats against those of humans. Historical dust lung burdens in coal miners were in the range of those associated with carcinogenicity in rats exposed to several dusts, but the carcinogenicity of coal dust in rats is unknown. The usefulness of tumor data from rats for predicting human lung cancer risk from inhaled silica and other dusts remains uncertain.

  7. Electronic energy-level structure, correlation crystal-field effects, and f-f transition intensities of Er{sup 3+} in Cs{sub 3}Lu{sub 2}Cl{sub 9}

    SciTech Connect (OSTI)

    Luethi, S.R.; Guedel, H.U. [Departement fuer Chemie und Biochemie, Universitaet Bern, Freiestrasse 3, CH-3000 Bern 9 (Switzerland)] [Departement fuer Chemie und Biochemie, Universitaet Bern, Freiestrasse 3, CH-3000 Bern 9 (Switzerland); Hehlen, M.P. [Optical Sciences Laboratory, The University of Michigan, 1301 Beal Avenue, Ann Arbor, Michigan 48109-2122 (United States)] [Optical Sciences Laboratory, The University of Michigan, 1301 Beal Avenue, Ann Arbor, Michigan 48109-2122 (United States); Quagliano, J.R. [Chemical Science and Technology Division, Los Alamos National Laboratory, Mail stop E543, Los Alamos, New Mexico 87545 (United States)] [Chemical Science and Technology Division, Los Alamos National Laboratory, Mail stop E543, Los Alamos, New Mexico 87545 (United States)

    1998-06-01T23:59:59.000Z

    Single crystals of 1{percent} Er{sup 3+}-doped Cs{sub 3}Lu{sub 2}Cl{sub 9} were grown using the Bridgman technique. From highly resolved polarized absorption spectra measured at 10 and 16 K, and upconversion luminescence and excitation spectra measured at 4.2 K, 114 crystal-field levels from 27 {sup 2S+1}L{sub J}(4f{sup 11}) multiplets of Er{sup 3+} were assigned. 111 of these were used for a semiempirical computational analysis. A Hamiltonian including only electrostatic, spin-orbit, and one-particle crystal-field interactions (C{sub 3v}) yielded a root-mean-square standard deviation of 159.8thinspcm{sup {minus}1} and could not adequately reproduce the experimental crystal-field energies. The additional inclusion of two- and three-body atomic interactions, giving a Hamiltonian with 16 atomic and 6 crystal-field parameters, greatly reduced the rms standard deviation to 22.75thinspcm{sup {minus}1}. The further inclusion of the correlation crystal-field interaction {cflx g}{sub 10A}{sup 4} again lowered the rms standard deviation to a final value of 17.98thinspcm{sup {minus}1} and provided substantial improvement in the calculated crystal-field splittings of mainly the J=9/2 or J=11/2 multiplets. However, the calculated baricenter energies of some excited-state multiplets deviate from their respective experimental values, and improvements in the atomic part of the effective Hamiltonian are required to correct this deficiency of the model. On the basis of the calculated electronic wave functions, the 12 electric-dipole intensity parameters (C{sub 3v}) of the total transition dipole strength were obtained from a fit to 95 experimental crystal-field transition intensities. The overall agreement between experimental and calculated intensities is fair. The discrepancies are most likely a result of using the approximate C{sub 3v} rather than the actual C{sub 3} point symmetry of Er{sup 3+} in Cs{sub 3}Lu{sub 2}Cl{sub 9} in the calculations. {copyright} {ital 1998} {ital The American Physical Society}

  8. Comparative Metabolism of Carbon Tetrachloride in Rats, Mice and Hamsters Using Gas Uptake and PBPK Modeling

    SciTech Connect (OSTI)

    Thrall, Karla D. (BATTELLE (PACIFIC NW LAB)); Vucelick, Mark E. (FLUOR HANFORD, INC); Gies, Richard A. (BATTELLE (PACIFIC NW LAB)); Zangar, Richard C. (BATTELLE (PACIFIC NW LAB)); Weitz, Karl K. (BATTELLE (PACIFIC NW LAB)); Poet, Torka S. (BATTELLE (PACIFIC NW LAB)); Springer, David L. (BATTELLE (PACIFIC NW LAB)); Grant, Donna M. (BATTELLE (PACIFIC NW LAB)); Benson, Janet M. (Inhalation Toxicology Research Institute)

    2000-08-25T23:59:59.000Z

    No study has comprehensively compared the rate of metabolism of carbon tetrachloride (CCl4) across species. Therefore, the in vivo metabolism of CCl4 was evaluated using groups of male animals (F344 rats, B6C3F1 mice, and Syrian hamsters) exposed to 40-1800 ppm CCl4 in a closed, recirculating gas-uptake system. For each species, an optimal fit of the family of uptake curves was obtained by adjusting Michaelis-Menten metabolic constants Km (affinity) and Vmax (capacity) using a physiologically based pharmacokinetic (PBPK) model. The results show that the mouse has a slightly higher capacity and lower affinity for metabolizing CCl4 compared to the rat, while the hamster has a higher capacity and lower affinity than either rat or mouse. A comparison of the Vmax to Km ratio, normalized for mg of liver protein (L/hr/mg) across species indicates that hamsters metabolize more CCl4 than either rats or mice, and should be more susceptible to CCl4-induced hepatotoxicity. These species comparisons were evaluated against toxicokinetic studies conducted in animals exposed by nose-only inhalation to 20 ppm 14C-labeled CCl4 for 4 hours. The toxicokinetic study results are consistent with the in vivo rates of metabolism, with rats eliminating less radioactivity associated with metabolism (14CO2 and urine/feces) and more radioactivity associated with the parent compound (radioactivity trapped on charcoal) compared to either hamsters or mice. The in vivo metabolic constants determined here, together with in vitro constants determined using rat, mouse, hamster and human liver microsomes, were used to estimate human in vivo metabolic rates of 1.49 mg/hr/kg body weight and 0.25 mg/L for Vmax and Km, respectively. Normalizing the rate of metabolism (Vmax/Km) by mg liver protein, the rate of metabolism of CCl4 differs across species, with hamster > mouse& > rat > human.

  9. Inhalation carcinogenicity study with nickel metal powder in Wistar rats

    SciTech Connect (OSTI)

    Oller, Adriana R. [NiPERA, 2605 Meridian Parkway, Suite 200, Durham, NC 27713 (United States)], E-mail: aoller@nipera.org; Kirkpatrick, Daniel T.; Radovsky, Ann [WIL Research Laboratories, LLC, 1407 George Road, Ashland, OH 44805 8946 (United States); Bates, Hudson K. [NiPERA, 2605 Meridian Parkway, Suite 200, Durham, NC 27713 (United States)

    2008-12-01T23:59:59.000Z

    Epidemiological studies of nickel refinery workers have demonstrated an association between increased respiratory cancer risk and exposure to certain nickel compounds (later confirmed in animal studies). However, the lack of an association found in epidemiological analyses for nickel metal remained unconfirmed for lack of robust animal inhalation studies. In the present study, Wistar rats were exposed by whole-body inhalation to 0, 0.1, 0.4, and 1.0 mg Ni/m{sup 3} nickel metal powder (MMAD = 1.8 {mu}m, GSD = 2.4 {mu}m) for 6 h/day, 5 days/week for up to 24 months. A subsequent six-month period without exposures preceded the final euthanasia. High mortality among rats exposed to 1.0 mg Ni/m{sup 3} nickel metal resulted in the earlier termination of exposures in this group. The exposure level of 0.4 mg Ni/m{sup 3} was established as the MTD for the study. Lung alterations associated with nickel metal exposure included alveolar proteinosis, alveolar histiocytosis, chronic inflammation, and bronchiolar-alveolar hyperplasia. No increased incidence of neoplasm of the respiratory tract was observed. Adrenal gland pheochromocytomas (benign and malignant) in males and combined cortical adenomas/carcinomas in females were induced in a dose-dependent manner by the nickel metal exposure. The incidence of pheochromocytomas was statistically increased in the 0.4 mg Ni/m{sup 3} male group. Pheochromocytomas appear to be secondary to the lung toxicity associated with the exposure rather than being related to a direct nickel effect on the adrenal glands. The incidence of cortical tumors among 0.4 mg Ni/m{sup 3} females, although statistically higher compared to the concurrent controls, falls within the historical control range; therefore, in the present study, this tumor is of uncertain relationship to nickel metal exposure. The lack of respiratory tumors in the present animal study is consistent with the findings of the epidemiological studies.

  10. Spatially selected synthesis of LaF{sub 3} and Er{sup 3+}-doped CaF{sub 2} crystals in oxyfluoride glasses by laser-induced crystallization

    SciTech Connect (OSTI)

    Kusatsugu, M.; Kanno, M.; Honma, T. [Department of Materials Science and Technology, Nagaoka University of Technology, 1603-1 Kamitomioka-cho, Nagaoka 940-2188 (Japan); Komatsu, T. [Department of Materials Science and Technology, Nagaoka University of Technology, 1603-1 Kamitomioka-cho, Nagaoka 940-2188 (Japan)], E-mail: komatsu@mst.nagaokaut.ac.jp

    2008-05-15T23:59:59.000Z

    Oxyfluoride glasses with a small amount of NiO are prepared using a conventional melt quenching technique, and the spatially selected crystallization of LaF{sub 3} and CaF{sub 2} crystals is induced on the glass surface by irradiations of continuous wave lasers with a wavelength of {lambda}=1064 or 1080 nm. Dots and lines including LaF{sub 3} crystals are patterned by heat-assisted (300 deg. C) laser irradiations ({lambda}=1064 nm) with a power of P=1 W and an irradiation time of 10 s for dots and a scanning speed of S=5 {mu}m/s for lines. Lines consisting of CaF{sub 2} crystals are also patterned in an ErF{sub 3}-doped oxyfluoride glass by laser irradiations ({lambda}=1080 nm) with a power of P=1.7 W and a scanning speed of S=2 {mu}m/s, and the incorporation of Er{sup 3+} ions into CaF{sub 2} crystals is confirmed from micro-photoluminescence spectrum measurements. It is proposed that the lines patterned by laser irradiations in this study are consisted of the composite of LaF{sub 3} or CaF{sub 2} nanocrystals and SiO{sub 2}-based oxide glassy phase. It is demonstrated that a combination of Ni{sup 2+}-dopings and laser irradiations is effective in spatially selected local crystallizations of fluorides in oxyfluoride glasses. - Graphical abstract: This figure shows the polarization optical and confocal scanning laser micrographs for lines obtained by laser irradiations with a laser power of P=1.7 W and a scanning speed of S=2 {mu}m/s in an oxyfluoride glass. It is proposed that the line consists of the composite of CaF{sub 2} nanocrystals and oxide glassy phase. This is the first demonstration on the patterning of fluoride crystals in glass by laser irradiations.

  11. In vitro dermal absorption of pyrethroid pesticides in human and rat skin

    SciTech Connect (OSTI)

    Hughes, Michael F., E-mail: hughes.michaelf@epa.go [Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Edwards, Brenda C. [Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States)

    2010-07-15T23:59:59.000Z

    Dermal exposure to pyrethroid pesticides can occur during manufacture and application. This study examined the in vitro dermal absorption of pyrethroids using rat and human skin. Dermatomed skin from adult male Long Evans rats or human cadavers was mounted in flow-through diffusion cells, and radiolabeled bifenthrin, deltamethrin or cis-permethrin was applied in acetone to the skin. Fractions of receptor fluid were collected every 4 h. At 24 h, the skins were washed with soap and water to remove unabsorbed chemical. The skin was then solubilized. Two additional experiments were performed after washing the skin; the first was tape-stripping the skin and the second was the collection of receptor fluid for an additional 24 h. Receptor fluid, skin washes, tape strips and skin were analyzed for radioactivity. For rat skin, the wash removed 53-71% of the dose and 26-43% remained in the skin. The cumulative percentage of the dose at 24 h in the receptor fluid ranged from 1 to 5%. For human skin, the wash removed 71-83% of the dose and 14-25% remained in the skin. The cumulative percentage of the dose at 24 h in the receptor fluid was 1-2%. Tape-stripping removed 50-56% and 79-95% of the dose in rat and human skin, respectively, after the wash. From 24-48 h, 1-3% and about 1% of the dose diffused into the receptor fluid of rat and human skin, respectively. The pyrethroids bifenthrin, deltamethrin and cis-permethrin penetrated rat and human skin following dermal application in vitro. However, a skin wash removed 50% or more of the dose from rat and human skin. Rat skin was more permeable to the pyrethroids than human skin. Of the dose in skin, 50% or more was removed by tape-stripping, suggesting that permeation of pyrethroids into viable tissue could be impeded. The percentage of the dose absorbed into the receptor fluid was considerably less than the dose in rat and human skin. Therefore, consideration of the skin type used and fractions analyzed are important when using in vitro dermal absorption data for risk assessment.

  12. Correction par voie nutritionnelle d'un excs d'acides gras insaturs dans les lipides corporels du rat en croissance

    E-Print Network [OSTI]

    Boyer, Edmond

    ). Hydrogenated coconut oil was a very effective substance for rapidly decreasing levels of reserve lipid linoleic acids in body lipids of growing rat. The use of hydrogenated coconut oil as a putative substance for correcting an excess of unsaturated fatty acids in reserve lipids was tested in growing rats. Young rats

  13. Dietary apigenin and naringenin protect against colon carcinogenesis by lowering high multiplicity aberrant crypt foci and enhancing apoptosis in azoxymethane-treated rats

    E-Print Network [OSTI]

    Leonardi, Tety

    2006-08-16T23:59:59.000Z

    investigated the potentially protective effects of four citrus flavonoids and one limonoid mixture against the promotion stage of chemically-induced colon cancer in rats. Male SD rats (n =60; 10 rats/group) were assigned to receive diets containing 0...

  14. Physiologically based Pharmacokinetic Modeling of 1,4-Dioxane in Rats, Mice, and Humans

    SciTech Connect (OSTI)

    Sweeney, Lisa M.; Thrall, Karla D.; Poet, Torka S.; Corley, Rick; Weber, Thomas J.; Locey, B. J.; Clarkson, Jacquelyn; Sager, S.; Gargas, M. L.

    2008-01-01T23:59:59.000Z

    ABSTRACT 1,4-Dioxane (CAS No. 123-91-1) is used primarily as a solvent or as a solvent stabilizer. It can cause lung, liver and kidney damage at sufficiently high exposure levels. Two physiologically-based pharmacokinetic (PBPK) models of 1,4-dioxane and its major metabolite, hydroxyethoxyacetic acid (HEAA), were published in 1990. These models have uncertainties and deficiencies that could be addressed and the model strengthened for use in a contemporary cancer risk assessment for 1,4-dioxane. Studies were performed to fill data gaps and reduce uncertainties pertaining to the pharmacokinetics of 1,4-dioxane and HEAA in rats, mice, and humans. Three types of studies were performed:partition coefficient measurements, blood time course in mice, and in vitro pharmacokinetics using rat, mouse, and human hepatocytes. Updated PBPK models were developed based on these new data and previously available data. The optimized rate of metabolism for the mouse was significantly higher than the value previously estimated. The optimized rat kinetic parameters were similar to those in the 1990 models. Only two human studies were identified. Model predictions were consistent with one study, but did not fit the second as well. In addition, a rat nasal exposure was completed. The results confirmed water directly contacts rat nasal tissues during drinking water under bioassays. Consistent with previous PBPK models, nasal tissues were not specifically included in the model. Use of these models will reduce the uncertainty in future 1,4-dioxane risk assessments.

  15. Final report for Texas A&M University Group Contribution to DE-FG02-09ER25949/DE-SC0002505: Topology for Statistical Modeling of Petascale Data (and ASCR-funded collaboration between Sandia National Labs, Texas A&M University and University of Utah)

    SciTech Connect (OSTI)

    Rojas, Joseph Maurice [Texas A& M University

    2013-02-27T23:59:59.000Z

    We summarize the contributions of the Texas A\\&M University Group to the project (DE-FG02-09ER25949/DE-SC0002505: Topology for Statistical Modeling of Petascale Data - an ASCR-funded collaboration between Sandia National Labs, Texas A\\&M U, and U Utah) during 6/9/2011 -- 2/27/2013.

  16. S T U D EN T A ND EN R OLM EN T S ER V I CE S DI V IS IO N In order to assist departments and colleges with their planning cycle for 2014-15 and beyond,

    E-Print Network [OSTI]

    Saskatchewan, University of

    Page | 1 S T U D EN T A ND EN R OLM EN T S ER V I CE S DI V IS IO N In order to assist departments: Key Dates and Deadlines for 2014-15 DATE: March 28, 2014 #12;Page | 2 S T U D EN T A ND EN R OLM EN

  17. Extracellular calcium sensing in rat aortic vascular smooth muscle cells

    SciTech Connect (OSTI)

    Smajilovic, Sanela [Laboratory of Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet (Denmark); Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen (Denmark); Hansen, Jakob Lerche [Laboratory of Molecular and Cellular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet (Denmark); Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen (Denmark); Christoffersen, Tue E.H. [Laboratory of Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet (Denmark); Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen (Denmark)] (and others)

    2006-10-06T23:59:59.000Z

    Extracellular calcium (Ca2+o) can act as a first messenger in many cell types through a G protein-coupled receptor, calcium-sensing receptor (CaR). It is still debated whether the CaR is expressed in vascular smooth muscle cells (VSMCs). Here, we report the expression of CaR mRNA and protein in rat aortic VSMCs and show that Ca2+o stimulates proliferation of the cells. The effects of Ca2+o were attenuated by pre-treatment with MAPK kinase 1 (MEK1) inhibitor, as well as an allosteric modulator, NPS 2390. Furthermore, stimulation of the VSMCs with Ca2+o-induced phosphorylation of ERK1/2, but surprisingly did not cause inositol phosphate accumulation. We were not able to conclusively state that the CaR mediates Ca2+o-induced cell proliferation. Rather, an additional calcium-sensing mechanism may exist. Our findings may be of importance with regard to atherosclerosis, an inflammatory disease characterized by abnormal proliferation of VSMCs and high local levels of calcium.

  18. Deregulation of Hepatic Insulin Sensitivity Induced by Central Lipid Infusion in Rats Is Mediated by Nitric Oxide

    E-Print Network [OSTI]

    Routh, Vanessa H.

    Deregulation of Hepatic Insulin Sensitivity Induced by Central Lipid Infusion in Rats Is Mediated effect of central lipid overload. Thus we infused rats for 24 hours into carotid artery towards brain). Principal Findings: Lipids infusion led to hepatic insulin-resistance partly related to a decreased

  19. Neutral sphingomyelinase inhibition participates to the benefits of N-acetylcysteine treatment in post-myocardial infarction failing heart rats

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    treatment in post- myocardial infarction failing heart rats Christophe ADAMY1,2,9 , Paul MULDER3,4,9 , Lara-MI failing heart rat Key words: chronic heart failure; glutathione; N-acetylcysteine; neutral, we showed that the left ventricle (LV) of human failing heart was depleted in total glutathione by 54

  20. Methods for testing the strength of cancellous bone and tested method effects on cortical bone in the ovariectomized rat

    E-Print Network [OSTI]

    Ruhmann, Sean Phillip

    1998-01-01T23:59:59.000Z

    In this study, two mechanical testing procedures were developed to test the strength of cancellous bone from the proximal tibia of the rat, the "punch method" and the "whole slice method". These were used to quantify the effect of ovariectomy on rat...

  1. Cardiovascular changes in unanesthetized and ketamine-anesthetized Sprague-Dawley rats exposed to 2. 8-GHz radiofrequency radiation

    SciTech Connect (OSTI)

    Jauchem, J.R.; Frei, M.R. (United States Air Force School of Aerospace Medicine, Brooks Air Force Base, TX (USA))

    1991-01-01T23:59:59.000Z

    Sprague-Dawley rats were exposed to 2.8-GHz radiofrequency radiation, first while unanesthetized and then while anesthetized with ketamine (150 mg/kg.I.M.). Irradiation at a power density of 60 mW/cm2 (whole-body average specific absorption rate of approximately 14 W/kg) was conducted for sufficient duration to increase colonic temperature from 38.5 to 39.5 degrees C. The time required for the temperature increase was significantly longer in the anesthetized state. During irradiation, heart rate increased significantly both with and without anesthesia, while mean arterial blood pressure increased only when the rats were unanesthetized. The heart rate increase in the anesthetized state contrasts with a lack of change in a previous study of Fischer rats. This difference between anesthetized Sprague-Dawley and Fischer rats should be considered when comparing cardiovascular data obtained from these two strains of rats.

  2. Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease

    SciTech Connect (OSTI)

    Wolff, J.A.; Fisher, L.J.; Xu, L.; Jinnah, H.A.; Rosenberg, M.B.; Shimohama, S.; Gage, F.H. (Univ. of California School of Medicine, La Jolla (USA)); Langlais, P.J. (Univ. of California School of Medicine, La Jolla (USA) School of Medicine and Veterans Administration Medical Center, La Jolla (USA) San Diego State Univ., CA (USA)); Iuvone, P.M. (Emory Univ., Atlanta, GA (USA)); O'Malley, K.L. (Washington Univ. School of Medicine, St. Louis, MO (USA))

    1989-11-01T23:59:59.000Z

    Rat fibroblasts were infected with a retroviral vector containing the cDNA for rat tyrosine hydroxylase. A TH-positive clone was identified by biochemical assay and immunohistochemical staining. When supplemented in vitro with pterin cofactors required for TH activity, these cells produced L-dopa and released it into the cell cultured medium. Uninfected control cells and fibroblasts infected with the TH vector were grafted separately to the caudate of rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. Only grafts containing TH-expressing fibroblasts were found to reduce rotational asymmetry. These results have general implications for the application of gene therapy to human neurological disease and specific implications for Parkinson disease.

  3. Chronic cellular responses of rat skin to 13 Mev proton irradiation

    E-Print Network [OSTI]

    Hinkle, Donald King

    1966-01-01T23:59:59.000Z

    CHRONIC CELLULAR RESPONSES OF RAT SKIN TO 13 MEV PROTON IRRADIATION A Thesis by DONALD KING HINKLE, D. V. M. Submitted to the Graduate College of the Texas AErM University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE August 1966 Major Subject: Laboratory Animal Medicine CHRONIC CELLULAR RESPONSES OF RAT SKIN TO 13 MEV PROTON IRRADIATION A Thesis by DONALD KING HINKLE, D. V. M. Submitted to the Graduate College of the Texas ARM University in partial...

  4. The inability of rats to synthesize linoleic acid from cis-2-octenoic acid

    E-Print Network [OSTI]

    Anderson, Robert Eugene

    2012-06-07T23:59:59.000Z

    THE INABILITY OF RATS TO SYNTHESI2E LINOLEIC ACID FROM CIS-2-OCTENOIC ACID A Thesis Robert Eugene Anderson Submitted to the Graduate College of the Texas A g: M University in partia1 fulfillment of the requirerents for the degree of MASTER... OF SCIENCE January 1965 Major Subjeot: Bioohemistry THE INABILITY OF RATS TQ SYNTHESIEE LINOLEIC ACID FROM CIS-2E)CTENOIC ACID A Thesis Robert, Eugene Anderson Approved as to style and content by: Chair n of Committee)~ (Head of Depart~ant, Member...

  5. Effect of passive and active immunization against somatostatin in growing rats and cattle

    E-Print Network [OSTI]

    Lawrence, Mark Elliott

    1985-01-01T23:59:59.000Z

    as in Exp. 1. Rats were infused daily with . 50 ml of either anti-SS or NGS and weighed every fifth day. Antiserum used to infuse treatment rats was the same used in Exp. l. 81ood samples were taken via cannula on d 5, 10, 15 and 20 of the experiment... calculated on 10 determinations of four plasma samples containing 1, 6, 10 and 30 ng GH/ml was 2, 3. 5, 6. 5, and 22. 8% respectively. The interassay coefficient of variation calculated on determination of the same four plasma samples in four different...

  6. Toxicity of polychlorinated diphenyl ethers in Hydra attenuata and in rat whole embryo culture

    E-Print Network [OSTI]

    Becker, Marion Carol

    1991-01-01T23:59:59.000Z

    TOXICITY OF POLYCHLORINATED DIPHENYL ETHERS IN HYDRA A?TENUATA AND IN RAT WHOLE EMBRYO CULTURE A Thesis by MARION CAROL BECKER Submitted to the Office of Graduate Studies of Texas A8cM University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE May 1991 Major Subject: Toxicology TOXICITY OF POLYCHLORINATED DIPHENYL ETHERS IN HYDRA A1TENUATA AND IN RAT WHOLE EMBRYO CULTURE by MARION CAROL BECKER Approved as to style and content by: Stephen H. S (Ca...

  7. Systematics of the southern races of two species of kangaroo rats (Dipodomys compactus and D. ordi)

    E-Print Network [OSTI]

    Baumgardner, George D

    1979-01-01T23:59:59.000Z

    University Chairman of Advisory Committee: Dr. David J. Schmidly The systematics of two species of kangaroo rats (g D~*d ~ ) f o y d * t!l* M * reviewed. Nongeographic and geographic variation was assessed among 63 samples (representing approximately... and that more than one biological species may occur 'n the area. These above studies imply tnat the ktngaroo rats from the barrier islands of Texas and H ' o ( f d t ~D' d 9 P T ', 1999( are specifically distinct from populations on the tt T ' 1 d ( f d t...

  8. Associative tolerance to nicotine analgesia in the rat: tail-flick and hot-plate assays

    E-Print Network [OSTI]

    Reynoso, Jose T.

    2012-06-07T23:59:59.000Z

    studies (e. g. , Miller, Rotenberg, 8c Adir, 1977; Sastry et al. , 1995) of intravenous (i. v. ) nicotine injections (0. 08, 0. 40, 0. 8 mg/kg and 1mg/kg respectively) in the rat (Sprague-Dawley and Fischer F344) indicate that it is rapidly... and extensively distributed and absorbed into the blood, brain, liver, and kidneys, and that it rapidly reaches peak concentrations. Sastry et al. (1995) reported peak nicotine levels in the rat brain, kidneys and liver were reached within five to ten minutes...

  9. 3-Methylhistidine excretion as an index of dietary protein adequacy in the rat

    E-Print Network [OSTI]

    Kirby, Rebecca Kay

    2012-06-07T23:59:59.000Z

    . Landmann The excretion of the amino acid, 3-methylhistidine (Nz-methyl- histidine, 3-MeHis), in urine has been shown to correlate with skel- etal muscle breakdown. In the rat, tissues such as skin, viscera, and liver in addition to skeletal muscle...-MeHis indicates the degree of catabolism of body proteins in rats (3). In addition to the contzibution of skeletal muscle, the higher turnover rate of skin, visceza, and liver contributes significantly to whole body protein breakdown in small...

  10. Synthesis, structure and properties of the oxychalcogenide series A{sub 4}O{sub 4}TiSe{sub 4} (A=Sm, Gd, Tb, Dy, Ho, Er and Y)

    SciTech Connect (OSTI)

    Tuxworth, A.J.; Evans, J.S.O., E-mail: john.evans@durham.ac.uk

    2014-02-15T23:59:59.000Z

    Seven oxyselenide materials have been synthesised with composition A{sub 4}O{sub 4}TiSe{sub 4} (A=Sm, GdEr, Y) via solid state reactions of A{sub 2}O{sub 3}, TiSe{sub 2} and Se at 900 C. They are all isostructural with Gd{sub 4}O{sub 4}TiSe{sub 4}. Structures have been refined from powder X-ray diffraction data and have monoclinic C2/m symmetry with unit cell parameters of a?15.7 , b?3.75 , c?9.65 and ??117.5. They contain infinite ribbons of edge-sharing A{sub 4}O and A{sub 3}TiO tetrahedra 4 units wide, which are linked by chains of TiSe{sub 4}O{sub 2} edge-sharing octahedra. Compositions A=GdHo, Y are semiconductors with conductivities 13 Sm{sup ?1} at 300 K, with electronic band gaps of between 0.25 and 0.37 eV. Magnetic susceptibility is reported from 1.8 K to 300 K for compositions A=GdHo. Rare earth moments appear to order antiferromagnetically at low temperatures with Gd and Tb showing evidence of ferromagnetism due to spin canting over a narrow temperature range close to T{sub N}. - Graphical abstract: Illustration of the A{sub 4}O{sub 4}TiSe{sub 4} crystal structure (C2/m symmetry), A{sub 4}O and A{sub 3}TiO edge sharing tetrahedral ribbons in red, chains of edge-sharing TiSe{sub 4}O{sub 2} in blue. Rare earth=green, titanium=blue, selenium=yellow, and oxygen=red. Display Omitted - Highlights: Seven materials with A{sub 4}O{sub 4}TiSe{sub 4} (A=Sm, GdEr, Y) have been synthesised as bulk phases for the first time. Materials are semiconductors and order antiferromagnetically at ?4 K. Structure contains M{sub 4}O tetrahedral ribbons and TiSe{sub 4}O{sub 2} 1D octahedral chains.

  11. Uptake and retention kinetics of para-fluorine-18-fluorobenzylguanidine in isolated rat heart

    SciTech Connect (OSTI)

    Berry, C.R.; Garg, P.K.; Zalutsky, M.R. [North Carolina State Univ., Raleigh, NC (United States)]|[Duke Univ. Medical Center, Durham, NC (United States)] [and others

    1996-12-01T23:59:59.000Z

    Para-[{sup 18}F]fluorobenzylguanidine ([{sup 18}F]PFBG) is a newly developed tracer for imaging myocardial sympathetic neuronal innervation. This study investigated the uptake and retention mechanisms of [{sup 18}F]PFBG in perfused, isolated rat heart. 31 refs., 3 figs., 2 tabs.

  12. Beneficial Effects of Hematopoietic Growth Factor Therapy in Chronic Ischemic Stroke in Rats

    E-Print Network [OSTI]

    Apkarian, A. Vania

    Beneficial Effects of Hematopoietic Growth Factor Therapy in Chronic Ischemic Stroke in Rats Li. Vania Apkarian, PhD; John A. Kessler, MD Background and Purpose--Stroke is the leading cause of adult disability worldwide. Currently, there is no effective treatment for stroke survivors. Stem cell factor (SCF

  13. The Effects of Alcohol and Age on Astrocytes In Female Rats Following an Inflammatory Stimulus

    E-Print Network [OSTI]

    Simpson, Ashley

    2009-09-30T23:59:59.000Z

    ------+ + + + + + + + + - - - + + + - - - MMP- 2 #0;? * Optica l Density Control Control+LPS Control+EtOH Control+LPS+EtOH Optica l Density Fig 6. MMP-2 lytic activity decreases in astrocytes derived from reproductive senescent female rats. LPS decreased MMP-2 lytic activity...

  14. Rat injury model under controlled field-relevant primary blast conditions: Acute response to a wide

    E-Print Network [OSTI]

    Farritor, Shane

    1 1 Rat injury model under controlled field-relevant primary blast conditions: Acute response.edu Keywords: Traumatic Brain Injury, Primary Blast, Mortality, Cellular Membrane Permeability, Lung Injury the risk of sustaining blast induced injury by military personnel and civilians. The blast injury

  15. A Glucose BioFuel Cell Implanted in Rats Philippe Cinquin1

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    A Glucose BioFuel Cell Implanted in Rats Philippe Cinquin1 *, Chantal Gondran2 , Fabien Giroud2 powerful ones, Glucose BioFuel Cells (GBFCs), are based on enzymes electrically wired by redox mediators applications. Citation: Cinquin P, Gondran C, Giroud F, Mazabrard S, Pellissier A, et al. (2010) A Glucose BioFuel

  16. Imaging Oxygen Consumption in Forepaw Somatosensory Stimulation in Rats Under Isoflurane Anesthesia

    E-Print Network [OSTI]

    Duong, Timothy Q.

    Imaging Oxygen Consumption in Forepaw Somatosensory Stimulation in Rats Under Isoflurane Anesthesia consumption, indicative of partial coupling of CBF and CMRO2. This study describes a useful forepaw. Following Fox et al.'s (2) initial study with positron emission tomography (PET), stimulus- evoked CMRO2

  17. Diffuse Optical Tomography of Cerebral Blood Flow, Oxygenation, and Metabolism in Rat During Focal Ischemia

    E-Print Network [OSTI]

    Yodh, Arjun G.

    of oxygen consumption (CMRO2). Temporary (60-minute) MCAO was performed on five rats. Ischemic changes--Cerebral metabolic rate of oxygen consumption. Diffuse optical tomography (DOT) of the brain is an attractive new complementary to those of magnetic resonance imaging (MRI) and positron emission tomog- raphy (PET), and holds

  18. anticoagulant-susceptible norway rats: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    anticoagulant-susceptible norway rats First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Assessing the...

  19. Effect of fermentable carbohydrates on volatile fatty acids, ammonia and mineral absorption in the rat caecum

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    intestine on caecal digestion and absorption have been studied in the rat. Even in diets lacking these carbo of the urea nitrogen was used in bacterial protein synthesis. Arteriovenous differences in the caecum showed, for which hydrolysing enzymes are lacking or poorly efficient in the small i ntesti ne. These carbohydrates

  20. UPTAKE OF [3H]-COLCHICINE INTO BRAIN AND LIVER OF MOUSE, RAT, AND CHICK

    E-Print Network [OSTI]

    Bennett, Edward L.

    2010-01-01T23:59:59.000Z

    by M.R. Rosenzweig and E.l. Bennett, Cambridge, MA: The MITJ.F. , D.W. landry, E.l. Bennett, and M.E. Jarvik. long-termRAT,AND CHICK Edward L. Bennett, Marie Hebert Alberti, and

  1. Inhalation developmental toxicology studies: Teratology study of acetone in mice and rats: Final report

    SciTech Connect (OSTI)

    Mast, T.J.; Evanoff, J.J.; Rommereim, R.L.; Stoney, K.H.; Weigel, R.J.; Westerberg, R.B.

    1988-11-01T23:59:59.000Z

    Acetone, an aliphatic ketone, is a ubiquitous industrial solvent and chemical intermediate; consequently, the opportunity for human exposure is high. The potential for acetone to cause developmental toxicity was assessed in Sprague-Dawley rats exposed to 0, 440, 2200, or 11000 ppm, and in Swiss (CD-1) mice exposed to 0, 440, 2200, and 6600 ppm acetone vapors, 6 h/day, 7 days/week. Each of the four treatment groups consisted of 10 virgin females (for comparison), and approx.32 positively mated rats or mice. Positively mated mice were exposed on days 6-17 of gestation (dg), and rats on 6-19 dg. The day of plug or sperm detection was designated as 0 dg. Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice (rats, 20 dg; mice, 18 dg). Implants were enumerated and their status recorded. Live fetuses were sexed and examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. 46 refs., 6 figs., 27 tabs.

  2. Mineral bone composition and some elements of calcium metabolism in magnesium-deficient growing rats

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Mineral bone composition and some elements of calcium metabolism in magnesium-deficient growing-Chomponelle, Theix, 63110 Beaumont, France. Summary. (1) Magnesium deficiency was induced in Sprague-Dawley male rats of deprivation. (3) The leg bones were fragmented as shown in figure 1. Their magnesium content had decreased

  3. Effect of dietary baobab oil on the hepatic ?-9 desaturase in the rat.

    E-Print Network [OSTI]

    Boyer, Edmond

    baobab seed oil (BO) or heated baobab oil (HBO) or a mixture of palm and sun- flower oils (MO). HeatEffect of dietary baobab oil on the hepatic ?-9 desaturase in the rat. JP Blond A Andrianaivo- seille Cedex 13, France) Refined baobab seed oil is consumed by the Mal- agasy population (inhabitants

  4. Regulation of metabolism during lactation in the rat D. H. WILLIAMSON

    E-Print Network [OSTI]

    Boyer, Edmond

    the lactose and protein and a high proportion of the lipid con- tained in rat milk are synthesized within, in particular, milk production, appears to depend on two hormo- nes, prolactin and insulin. Secretion responsible for regula- tion of insulin secretion from the pancreas. The apparent paradox in lactation

  5. Resveratrol Improves Survival, Hemodynamics and Energetics in a Rat Model of Hypertension Leading to

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Resveratrol Improves Survival, Hemodynamics and Energetics in a Rat Model of Hypertension Leading and vascular function as well as cardiac and skeletal muscle energy metabolism were assessed in a hypertensive/kg/day; HS-RSV) was given for 8 weeks after hypertension and cardiac hypertrophy were established (which

  6. Gender Differences in Transcriptional Signature of Developing Rat Testes and Ovaries following Embryonic

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Dioxins are persistent organic pollutants interfering with endocrine systems and causing reproductive,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) on reproductive function of male and female offspring in the rat with a special fertility of the progeny. We choose a global gene expression approach using Affymetrix microarray analysis

  7. 5-Hydroxy-L-tryptophan suppresses food intake in food-deprived and stressed rats

    E-Print Network [OSTI]

    Wurtman, Richard

    - hydroxy-L-tryptophan (5-HTP), serotonin's immediate intracellular precursor, has been thought inhibitor to protect 5-HTP from destruction outside the brain. We have examined the effect of 5-HTP on food consumption and tissue 5-HTP levels among rats subjected to two different hyperphagic stimuli, food

  8. A study of the effect of restricted diets in the male albino rat

    E-Print Network [OSTI]

    Griffin, Travis Barton

    1961-01-01T23:59:59.000Z

    CLon exxpertment metabolic rate was also osti mated by means ?f serum clearance of radioactive I?dine. This determination was ne during tho twenty fourth week of the superi ment on five animals from each Creatment group. Each rat was infected intraperitoneally...

  9. Induced Hypothermia During Resuscitation from Hemorrhagic Shock Attenuates Microvascular Inflammation in the Rat Mesenteric Microcirculation

    E-Print Network [OSTI]

    Coyan, Garrett Nicholas

    2013-08-31T23:59:59.000Z

    INDUCED HYPOTHERMIA DURING RESUSCITATION FROM HEMORRHAGIC SHOCK ATTENUATES MICROVASCULAR INFLAMMATION IN THE RAT MESENTERIC MICROCIRCULATION BY GARRETT NICHOLAS COYAN BS, UNIVERSITY OF MICHIGAN, 2009 Submitted to the graduate degree... program in Clinical Research and the Graduate Faculty of the University of Kansas in partial fulfillment of the requirements for the degree of Master of Science. ________________________________ Chairperson Edward F. Ellerbeck, MD, MPH...

  10. Grid Cells and Theta as Oscillatory Interference: Electrophysiological Data From Freely Moving Rats

    E-Print Network [OSTI]

    Burgess, Neil

    Grid Cells and Theta as Oscillatory Interference: Electrophysiological Data From Freely Moving Rats, regular firing patterns by medial entorhinal cortical (mEC) grid cells in terms of the interference specific relationships between the intrinsic firing frequency and spa- tial scale of grid cell firing

  11. Polycyclic Aromatic Hydrocarbons Present in Cigarette Smoke Cause Bone Loss in an Ovariectomized Rat Model

    E-Print Network [OSTI]

    Waldman, Stephen D.

    of epidemiological studies have suggested that cigarette smoking is a risk factor for osteoporosis. Benzo- (a and fragility seen in smoking-related osteoporosis. In this study four groups of 9-month-old Sprague-Dawley rats; Ovariectomy (ovx); Estrogen; Osteoporosis. Introduction Epidemiological studies have focused

  12. Some histological manifestations in the vitamin B b12 sdeficient newborn rat

    E-Print Network [OSTI]

    Jones, Carroll Christian

    1954-01-01T23:59:59.000Z

    &dna;, . and spieen 1n duced by a materw?l v1tamin Rl? deficiency 1? the ?suborn albino rat, 4 secondary porno a Ips to co"lpga e the '?Jot'. , +t dif faro loca bot'i&en the hearts, livorn and '. . Tdnevs of novborn offspring oi' v'to oin Q2 deficient mothers...

  13. Effects of dietary fat, fiber and carcinogen on fecal diacylglcyerols in the rat

    E-Print Network [OSTI]

    Pickering, Jennifer Sharon

    1996-01-01T23:59:59.000Z

    of physiological modifiers such as diet and carcinogen on fecal DAG mass and composition have not been reported. We designed a 2 x 2 x 2 factorial study (2 fats: corn oil 'I and fish oil; 2 fibers: pectin and 'Cellulose; with and without carcinogen). Rats were...

  14. Studies on Pentoxifylline and Tocopherol Combination for Radiation-Induced Heart Disease in Rats

    SciTech Connect (OSTI)

    Liu Hui [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Xiong Mai [Department of Cardiac Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong (China); Xia Yunfei; Cui Nianji; Lu Rubiao [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Radiotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Deng Ling [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Pathology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Lin Yuehao [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Clinical Laboratory, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China); Rong Tiehua [State Key Laboratory of Oncology in South China, Guangzhou, Guangdong (China); Department of Thoracic Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong (China)], E-mail: esophagus2003@yahoo.com.cn

    2009-04-01T23:59:59.000Z

    Purpose: To investigate whether the application of pentoxifylline (PTX) and tocopherol l (Vit. E) could modify the development of radiation-induced heart disease and downregulate the expression of transforming growth factor (TGF)-{beta}1mRNA in rats. Methods and Materials: A total of 120 Sprague-Dawley rats were separated into four groups: control group, irradiated group, experimental group 1, and experiment group 2. Supplementation was started 3 days before irradiation; in experimental group 1, injection of PTX (15 mg/kg/d) and Vit. E (5.5 mg/kg/d) continued till the 12th week postirradiation, whereas in experimental group 2 it was continued until the 24th week postirradiation. All rats were administrated a single dose of 20 Gy irradiation to the heart except the control group. Histopathologic evaluation was performed at various time points (Days 1, 2, 4, 8, and 12 and 24th week) up to 24 weeks after irradiation. Changes of levels of TGF-{beta}1 mRNA expression were also investigated at the same time points using competitive polymerase chain reaction. Results: Compared with the irradiated group, levels of TGF-{beta}1 mRNA of the rat hearts were relatively low in the two experimental groups on the 12th week postirradiation. In experimental group 1, there was a rebound expression of TGF-{beta}1 mRNA on the 24th week postirradiation, whereas that of the experimental group 2 remained low (p < 0.05). The proportions of collagen fibers of the two experimental groups were lower than that of irradiated group (p < 0.05). A rebound could be observed in the experimental group 1. Conclusion: PTX and Vit. E downregulated the expression of TGF-{beta}1 mRNA. The irradiated rat hearts showed a marked pathologic response to the drugs. The withdrawal of drugs in the 12th week postirradiation could cause rebound effects of the development of fibrosis.

  15. Myocardial kinetics of carbon-11-epinephrine in the isolated working rat heart

    SciTech Connect (OSTI)

    Nguyen, N.T.B.; DeGrado, T.R.; Chakraborty, P. [Univ. of Michigan, Ann Arbor, MI (United States)] [and others

    1997-05-01T23:59:59.000Z

    The kinetics of EPI were studied in the isolated rat heart model to evaluate {sup 11}C-epinephrine (EPI) as a radiotracer for the assessment of sympathetic neuronal function in the heart. Isolated rat hearts were perfused in a working mode. Carbon-11-EPI was added to the perfusate during wash-in period of 20 min, followed by a washout period of 40 min. Radioactivity in the heart was externally monitored and time-activity curves were recorded as a function of time. Effluent samples were collected throughout each study to determine the fraction of {sup 11}C radioactivity as intact tracer. Time-activity curves of control hearts showed that {sup 11}C-EPI is taken up and retained by the myocardium. Desipramine inhibition (DMI) of uptake-1 resulted in a significant decrease in myocardial uptake and retention of {sup 11}C-EPI by 91% compared to controls. Addition of DMI to the perfusion medium during washout did not affect kinetics of {sup 11}C-EPI compared to control hearts. Reserpine pretreated rat hearts also showed significant decrease in tracer retention of 95% compared to controls. The metabolic data showed that, in control conditions, about 61% of {sup 11}C-EPI taken up by the rat heart is rapidly metabolized and released. Carbon-11-EPI traces sympathetic nerve terminals in the isolated rat heart. Uptake blockade by DMI and reserpine suggest that uptake and storage of {sup 11}C-EPI appear to be similar to that of norepinephrine. However, the prominent metabolic pathway warrants further consideration. These results suggest that {sup 11}C-EPI may be a suitable radiolabeled tracer for the evaluation of sympathetic vesicular function of the heart by PET. 23 refs., 3 figs., 3 tabs.

  16. Anesthesia with propofol induces insulin resistance systemically in skeletal and cardiac muscles and liver of rats

    SciTech Connect (OSTI)

    Yasuda, Yoshikazu; Fukushima, Yuji; Kaneki, Masao [Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospitals for Children, Harvard Medical School, Boston, MA 02114 (United States)] [Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospitals for Children, Harvard Medical School, Boston, MA 02114 (United States); Martyn, J.A. Jeevendra, E-mail: jmartyn@partners.org [Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospitals for Children, Harvard Medical School, Boston, MA 02114 (United States)] [Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospitals for Children, Harvard Medical School, Boston, MA 02114 (United States)

    2013-02-01T23:59:59.000Z

    Highlights: ? Propofol, as a model anesthetic drug, induced whole body insulin resistance. ? Propofol anesthesia decreased glucose infusion rate to maintain euglycemia. ? Propofol decreased insulin-mediated glucose uptake in skeletal and cardiac muscles. ? Propofol increased hepatic glucose output confirming hepatic insulin resistance. -- Abstract: Hyperglycemia together with hepatic and muscle insulin resistance are common features in critically ill patients, and these changes are associated with enhanced inflammatory response, increased susceptibility to infection, muscle wasting, and worsened prognosis. Tight blood glucose control by intensive insulin treatment may reduce the morbidity and mortality in intensive care units. Although some anesthetics have been shown to cause insulin resistance, it remains unknown how and in which tissues insulin resistance is induced by anesthetics. Moreover, the effects of propofol, a clinically relevant intravenous anesthetic, also used in the intensive care unit for sedation, on insulin sensitivity have not yet been investigated. Euglycemic hyperinsulinemic clamp study was performed in rats anesthetized with propofol and conscious unrestrained rats. To evaluate glucose uptake in tissues and hepatic glucose output [{sup 3}H]glucose and 2-deoxy[{sup 14}C]glucose were infused during the clamp study. Anesthesia with propofol induced a marked whole-body insulin resistance compared with conscious rats, as reflected by significantly decreased glucose infusion rate to maintain euglycemia. Insulin-stimulated tissue glucose uptake was decreased in skeletal muscle and heart, and hepatic glucose output was increased in propofol anesthetized rats. Anesthesia with propofol induces systemic insulin resistance along with decreases in insulin-stimulated glucose uptake in skeletal and heart muscle and attenuation of the insulin-mediated suppression of hepatic glucose output in rats.

  17. Final Report for U.S. DOE GRANT No. DEFG02-96ER41015 November 1, 2010 - April 30, 2013 entitled HIGH ENERGY ACCELERATOR AND COLLIDING BEAM USER GROUP at the UNIVERSITY of MARYLAND

    SciTech Connect (OSTI)

    Hadley, Nicholas [University of Maryland College Park; Jawahery, Abolhassan [University of Maryland College Park; Eno, Sarah C [University of Maryland College Park; Skuja, Andris [University of Maryland College Park; Baden, Andrew [University of Maryland College Park; Roberts, Douglas [University of Maryland College Park

    2013-07-26T23:59:59.000Z

    We have #12;finished the third year of a three year grant cycle with the U.S. Department of Energy for which we were given a #12;five month extension (U.S. D.O.E. Grant No. DEFG02-96ER41015). This document is the fi#12;nal report for this grant and covers the period from November 1, 2010 to April 30, 2013. The Maryland program is administered as a single task with Professor Nicholas Hadley as Principal Investigator. The Maryland experimental HEP group is focused on two major research areas. We are members of the CMS experiment at the LHC at CERN working on the physics of the Energy Frontier. We are also analyzing the data from the Babar experiment at SLAC while doing design work and R&D towards a Super B experiment as part of the Intensity Frontier. We have recently joined the LHCb experiment at CERN. We concluded our activities on the D#31; experiment at Fermilab in 2009.

  18. Modeling of optical amplifier waveguide based on silicon nanostructures and rare earth ions doped silica matrix gain media by a finite-difference time-domain method: comparison of achievable gain with Er3+ or Nd3+ ions dopants

    E-Print Network [OSTI]

    Cardin, Julien; Dufour, Christian; Gourbilleau, Fabrice

    2015-01-01T23:59:59.000Z

    A comparative study of the gain achievement is performed in a waveguide optical amplifier whose active layer is constituted by a silica matrix containing silicon nanograins acting as sensitizer of either neodymium ions (Nd 3+) or erbium ions (Er 3+). Due to the large difference between population levels characteristic times (ms) and finite-difference time step (10 --17 s), the conventional auxiliary differential equation and finite-difference time-domain (ADE-FDTD) method is not appropriate to treat such systems. Consequently, a new two loops algorithm based on ADE-FDTD method is presented in order to model this waveguide optical amplifier. We investigate the steady states regime of both rare earth ions and silicon nanograins levels populations as well as the electromagnetic field for different pumping powers ranging from 1 to 10 4 mW.mm-2. Furthermore, the three dimensional distribution of achievable gain per unit length has been estimated in this pumping range. The Nd 3+ doped waveguide shows a higher gross...

  19. Measurement of g-factors of ground and excited optical states of Er3+ in YLiF4 and LuLiF4 in zero dc magnetic field by photon echo method

    E-Print Network [OSTI]

    Lisin, V N; Samartsev, V V

    2014-01-01T23:59:59.000Z

    New scheme of definition of g-factors as ground as excited optical states of a paramagnetic ion in zero external constant magnetic field has been proposed and experimentally realized in optical systems in which Zeeman Effect is manifested. A pulse of a weak magnetic field leads to occurrence of relative phase shifts of the excited dipoles and, as consequence, to modulation of a photon echo waveform if magnetic pulse (MP) overlaps in time with echo-pulse. The modulation periods of the waveform depend on polarization of the laser light, which excites the photon echo. The values of these periods for {\\sigma}- and {\\pi}- laser light polarization have been measured and then the g-factors of the ground 4I15/2 and excited 4F9/2 states of the Er3+ ion in the LuLiF4 and the YLiF4 matrices have been determined. Values of the g-factors have been compared with the known literary data.

  20. DOE 5700.6C, 10CFR830.120, DOE-ER-STD-6001-92, and Covey-based TQM: A historical perspective on current issues in research environments

    SciTech Connect (OSTI)

    Bodnarczuk, M.

    1994-06-01T23:59:59.000Z

    Three years ago there were no standards or published guidelines for quality in research environments. Today, one standard has been published, and three guidelines documents are in final draft form and about to be published. In this paper, I describe the events that led to the writing of DOE 5700.6C, 10CFR830.120, and DOE-ER-STD-6001-92, focusing on the cultural barriers that arose (largely in the community of quality assurance professionals) during this process. I go on to describe why I believe that implementing DOE 5700.6C and 10CFR830.120 must be pushed even further toward an approach that embodies the Malcolm Baldrige National Quality Award and why even this is not far enough. The reason is because the most crucial aspect of successfully implementing a quality initiative is to base it on a cohesive, unified foundation of organizational and individual values and beliefs. Stephen Covey`s 7 Habits of Highly Effective People and Principle Centered Leadership provide such a foundations.

  1. Retinal ganglion cell survival and axon regeneration in WldS transgenic rats after optic nerve crush and lens injury

    E-Print Network [OSTI]

    Lorber, Barbara; Tassoni, Alessia; Bull, Natalie D; Moschos, Marilita M; Martin, Keith R

    2012-06-06T23:59:59.000Z

    Abstract Background We have previously shown that the slow Wallerian degeneration mutation, whilst delaying axonal degeneration after optic nerve crush, does not protect retinal ganglion cell (RGC) bodies in adult rats. To test the effects of a...

  2. Redescription of the enigmatic long-tailed rat Sigmodontomys aphrastus (Cricetidae: Sigmodontinae) with comments on taxonomy and natural history

    E-Print Network [OSTI]

    McCain, Christy M.; Timm, Robert M.; Weksler, Marcelo

    2007-08-01T23:59:59.000Z

    Sigmodontomys aphrastus, the long-tailed rat, is an exceedingly rare rodent species from montane regions of Central and South America of which very little is known ecologically or systematically. It has been variously ...

  3. The role of constrictor prostanoids in the development of aortic coarctation-induced hypertension in male and female rats

    E-Print Network [OSTI]

    Baltzer, Wendy Irene

    2005-02-17T23:59:59.000Z

    function and arterial blood pressure (MAP) during development of aortic coarctation-induced hypertension (HT). M and F rats, (15-18 wks.) in four groups: normotensive (NT), hypertensive (HT), ovariectomized (OVX), and OVX estrogen-replaced (OE), underwent...

  4. Quantifying the strain response in the rat tibia during simulated resistance training used as a disuse countermeasure

    E-Print Network [OSTI]

    Jeffery, Jay Melvin

    2009-05-15T23:59:59.000Z

    loss. This study used a hindlimb unloaded (HU) rat model to simulate microgravity and a muscle stimulation countermeasure to simulate resistive exercise. Uniaxial strain gages were implanted on the antero-medial aspect of the proximal tibia to measure...

  5. Quantifying the strain response in the rat tibia during simulated resistance training used as a disuse countermeasure

    E-Print Network [OSTI]

    Jeffery, Jay Melvin

    2008-10-10T23:59:59.000Z

    loss. This study used a hindlimb unloaded (HU) rat model to simulate microgravity and a muscle stimulation countermeasure to simulate resistive exercise. Uniaxial strain gages were implanted on the antero-medial aspect of the proximal tibia to measure...

  6. Effect of dietary protein quality on fractional rates of muscle protein synthesis and catabolism in the rat

    E-Print Network [OSTI]

    Roeder, Richard Anthony

    1979-01-01T23:59:59.000Z

    EFFECT OF DIETARY PROTEIN QUALITY ON FRACTIONAL RATES OF MUSCLE PROTEIN SYNTHESIS AND CATABOLISM IN THE RAT A Thesis by RICHARD ANTHONY ROEDER Submitted to the Graduate College of Texas A8cM University in partial fulfillment... of the requirement for the degree of MASTER OF SCIENCE August 1979 Major Subject: Animal Nutrition EFFECT OF DIETARY PROTEIN QUALITY ON FRACTIONAL RATES OF MUSCLE PROTEIN SYNTHESIS AND CATABOLISM IN THE RAT A Thesis by RICHARD ANTHONY ROEDER Approved...

  7. The effects of a suboptimal intake of magnesium with soy protein concentrate on parturition, growth, and viability in the rat

    E-Print Network [OSTI]

    Carson, Sonja D'Awn

    2012-06-07T23:59:59.000Z

    THE EFFECTS OF A SUBOPTIMAL INTAKE OF MAGNESIUM WITH SOY PROTEIN CONCENTRATE ON PARTURITION, GROWTH, AND VIABILITY IN THE RAT A Thesis by SONJA D'AWN CARSON Submitted to the Graduate College of Texas AEM University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE December 1985 Major Subject: Nutrition THE EFFECTS OF A SUBOPTIMAL INTAKE OF MAGNESIUM WITH SOY PROTEIN CONCENTRATE ON PARTURITIONe GROWTH, AND VIABILITY IN THE RAT A Thesis by SONJA D'AWN CARSON...

  8. Short term effects of commercial polychlorinated biphenyl (PCB) mixtures and individual PCB congeners in female Sprague-Dawley rats

    E-Print Network [OSTI]

    Chen, Yu-Chyu

    1992-01-01T23:59:59.000Z

    SHORT TERM EFFECTS OF COMMERCIAL POLYCHLORINATED BIPHENYL (PCB) MIXTURFS AND INDIVIDUAL PCB CONGENERS IN FEMALE SPRAGUE-DAWLEY RATS A Thesis by YU-CHYU CHEN Submitted to the Office of Graduate Studies of Texas A&M University in partial... fulfillment of the requirements for the degree of MASTER OF SCIENCE December 1992 Major subject: Toxicology SHORT TERM EFFECTS OF COMMERCIAL POLYCHLORINATED BIPHENYL (PCB) MIXTURES AND INDIVIDUAL PCB CONGENERS IN FEMALE SPRAGUE-DAWLEY RATS A Thesis...

  9. The Effects of Habitat Fragmentation on the Behavior of the Cotton Rat (Sigmodon hispidus):Phase II

    SciTech Connect (OSTI)

    Barrett, G.W.; Drelin, E.A.; Mabry, K.E.

    2001-07-01T23:59:59.000Z

    The authors studied the movements of cotton rats and cotton mice in experimental landscapes at the SRS in order to determine the effects of fragmentation and connectivity between habitat patches on dispersal movements and population dynamics. Densities between connected and isolated patches were not different. Small patches tended to support higher densities. Cotton rats were more common in corridors than expected and cotton mice were more likely to leave by a corridor.

  10. An investigation of the potentiating effects of ethanol on a chronic exposure of rats to 1,1,1-trichloroethane

    E-Print Network [OSTI]

    Walker, DeWayne Harold

    1973-01-01T23:59:59.000Z

    AN INVESTIGATION OF THE POTENTIATING EFFECTS OF ETHANOL ON A CHRONIC EXPOSURE OF RATS TO 1, 1&I-TRICHLOROETHANE A Thesis by DEWAYNE HAROLD WALKER Submitted to the Graduate College of Texas AFM University in partial fulfillment... of the requirement for the degree of MASTER OF SCIENCE August 1973 Major Subject: Laboratory Animal Medicine AN INVESTIGATION OF THE POTENTIATING EFFECTS OF ETHANOL ON A CHRONIC EXPOSURE OF RATS TQ 1&1, 1-TRICHLOROETHANE A Thesis by DENAYNE HAROLD WALKER...

  11. Blood risk factor metabolites associated with heart disease and myocardial fatty acids in copper-deficient male and female rats

    SciTech Connect (OSTI)

    Fields, M.; Lewis, C.; Beal, T. (Georgetown Univ. Medical School, WA (USA)); Berlin, E.; Kliman, P.G.; Peters, R.C. (Department of Agriculture, Beltsville, MD (USA))

    1989-07-01T23:59:59.000Z

    Intact and castrated males and intact and ovariectomized female rats were fed a copper-deficient diet in order to establish whether the protection provided in females against cardiovascular pathology and mortality is due to endogenous sex hormones, and different levels of blood lipids and/or myocardial fatty acids. Seventy-three male and female rats were assigned to a copper-deficient diet (0.6 {mu}g of copper/g diet) containing 62% fructose for 8 weeks. Twelve of the male rats underwent castration and 12 of the females were ovariectomized. All animals exhibited high levels of plasma cholesterol, triglycerides, and uric acid, which were neither affected by the sex of the rat nor by the surgical treatment. The composition of fatty acids of the myocardium was similar in males and females. Except for those animals that were sacrificed by us, all other male rats died of heart pathology. In contrast, none of the female rats exhibited heart pathology and none died of the deficiency. It is suggested that heart pathology and mortality in copper deficiency are sex related and not due to high levels of plasma cholesterol, triglycerides, and uric acid or to differences in myocardial fatty acid composition.

  12. Synthesis, structural characterization and Mssbauer study of LnV{sub 0.5}Fe{sub 0.5}O{sub 3} perovskites (Ln = Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho and Er)

    SciTech Connect (OSTI)

    Ivashita, Flvio F.; Biondo, Valdecir; Bellini, Jusmar V.; Paesano, Andrea [Departamento de Fsica, Universidade Estadual de Maring, Av. Colombo 5790, 87.020-900 Maring, PR (Brazil)] [Departamento de Fsica, Universidade Estadual de Maring, Av. Colombo 5790, 87.020-900 Maring, PR (Brazil); Blanco, M. Cecilia; Fuertes, Valeria C.; Pannunzio-Miner, Elisa V. [INFIQC-CONICET, Departamento de Fisicoqumica, Facultad de Ciencias Qumicas, Universidad Nacional de Crdoba, X5000HUA Crdoba (Argentina)] [INFIQC-CONICET, Departamento de Fisicoqumica, Facultad de Ciencias Qumicas, Universidad Nacional de Crdoba, X5000HUA Crdoba (Argentina); Carbonio, Ral E., E-mail: carbonio@fcq.unc.edu.ar [INFIQC-CONICET, Departamento de Fisicoqumica, Facultad de Ciencias Qumicas, Universidad Nacional de Crdoba, X5000HUA Crdoba (Argentina)

    2012-09-15T23:59:59.000Z

    Graphical abstract: Mssbauer spectra taken at 200 K for the Y(V{sub 0.5}Fe{sub 0.5})O{sub 3} orthoferrivanadate synthesized by arc-melting. Highlights: ? LnFe{sub 0.5}V{sub 0.5}O{sub 3} were synthesized by the first time for most of the rare-earth elements. ? These orthoferrivanadates crystallize metastably with the perovskite structure. ? Iron and vanadium are trivalent stabilized in these solid solutions. ? The Mssbauer quadrupolar splitting is correlated with the tolerance factor. ? Below 100 K, these perovskites undergo a crystallographic phase transformation. -- Abstract: Perovskites LnV{sub 0.5}Fe{sub 0.5}O{sub 3} (Ln = Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho and Er) were synthesized by rapid solidification from arc-melted samples and characterized by the study of their crystal structure and hyperfine properties. These metastable solid solutions crystallized in the Pbnm symmetry, with the iron and vanadium cations randomly distributed in the transition metal octahedral sites. Depending on the lanthanide present at the A site of the perovskite, iron is present with two valences (i.e., Fe{sup 3+} and Fe{sup 2+}). The volume of the unit cell for these perovskites increases linearly with the lanthanide ionic radius, as the perovskite approaches its ideal structure. At room temperature, the quadrupolar splitting of the trivalent paramagnetic Mssbauer component works as an indirect measurement for the Goldshmidt tolerance factor. Close to or below 100 K, these perovskites undergo a crystallographic phase transformation, probably due to orbital ordering of the V{sup 3+} cations, originating two different magnetic iron sites.

  13. Protective effects of tocotrienols against lipid-induced nephropathy in experimental type-2 diabetic rats by modulation in TGF-? expression

    SciTech Connect (OSTI)

    Siddiqui, Shabeena [Department of Biochemistry, Lipid Metabolism Laboratory, Jamia Hamdard (Hamdard University), New Delhi 110062 (India); Ahsan, Haseeb [Department of Biochemistry, Faculty of Dentistry, Jamia Millia Islamia, New Delhi 110025 (India); Khan, Mohammad Rashid [Department of Biochemistry, Lipid Metabolism Laboratory, Jamia Hamdard (Hamdard University), New Delhi 110062 (India); Siddiqui, Waseem A., E-mail: wasiddiqui01@gmail.com [Department of Biochemistry, Lipid Metabolism Laboratory, Jamia Hamdard (Hamdard University), New Delhi 110062 (India)

    2013-12-01T23:59:59.000Z

    Dyslipidemia is common in patients with diabetes mellitus (DM) and is considered a risk factor for the progression of diabetic nephropathy (DN). Hyperlipidemia and hyperglycemia act synergistically to induce renal injury. The present study was designed to investigate the protective effects of tocotrienols as tocotrienol-rich fraction (TRF) extracted from palm (PO) and rice bran oils (RBO) against lipid induced nephropathy in type-2 diabetic rats and its probable molecular mechanism. Male Wistar rats (175200 g) were divided into four groups. The first group served as diabetic control, while the second and third groups received PO-TRF and RBO-TRF, respectively by gavage over a period of sixteen weeks post-induction of diabetes. The fourth group comprised of age-matched rats that served as normal control. The effects of TRF on serum lipid profile, oxidative stress markers, expression of TGF-?, fibronectin and collagen type IV were analyzed in the kidney of diabetic rats. Treatment with PO-TRF and RBO-TRF significantly improved glycemic status, serum lipid profile and renal function in type-2 diabetic rats. In addition, TRF supplementation down-regulated the expression of TGF-?, fibronectin and collagen type IV in the kidney of diabetic rats. Transforming growth factor-? (TGF-?) plays a critical role in progression of DN, but its modulation by tocotrienols in DN remains unexplored. TRF ameliorated lipid induced nephropathy in type-2 diabetes by its hypoglycemic, hypolipidemic and antioxidant activities as well as by modulation of TGF-? to prevent increased expression of collagen type IV and fibrinogen. We finally propose a mechanism for the expression of molecular markers that are significant in the events leading to diabetic nephropathy and its modulation by tocotrienols/TRF. - Highlights: The nephroprotective effect of TRF in type-2 diabetic rats was investigated. Treatment with TRF improved glycemic status, lipid profile and renal functions in rats. TRF down-regulated the expression of TGF-?, fibronectin and collagen in rats' kidney. TRF ameliorated nephropathy by hypoglycemic, hypolipidemic and antioxidant activity. Tocotrienols modulate the expression of TGF-? in DN in type-2 diabetic rats.

  14. Effect of freezing on the coupling of VIP receptors to adenylate cyclase in rat liver membranes

    SciTech Connect (OSTI)

    Robberecht, P.; Waelbroeck, M.; De Neef, P.; Camus, J.C.; Gourlet, P.; Christophe, J.

    1988-01-01T23:59:59.000Z

    In fresh rat liver plasma membranes high affinity VIP receptors were specifically labelled with (/sup 125/I) helodermin and were well coupled to adenylate cyclase while low affinity VIP receptors were not. After freezing and thawing low affinity VIP receptors were also coupled to adenylate cyclase. This modification of adenylate cyclase activation was specific for the VIP response as freezing and thawing did not modify Gpp(NH)p, NaF and glucagon stimulations. 26 references, 3 figures, 1 table.

  15. Comparative effects of sodium channel blockers in short term rat whole embryo culture

    SciTech Connect (OSTI)

    Nilsson, Mats F, E-mail: Mats.Nilsson@farmbio.uu.se [Department of Pharmaceutical Biosciences, Uppsala University (Sweden); Skld, Anna-Carin; Ericson, Ann-Christin; Annas, Anita; Villar, Rodrigo Palma [AstraZeneca R and D Sdertlje (Sweden); Cebers, Gvido [AstraZeneca R and D, iMed, 141 Portland Street, Cambridge, MA 02139 (United States); Hellmold, Heike; Gustafson, Anne-Lee [AstraZeneca R and D Sdertlje (Sweden); Webster, William S [Department of Anatomy and Histology, University of Sydney (Australia)

    2013-10-15T23:59:59.000Z

    This study was undertaken to examine the effect on the rat embryonic heart of two experimental drugs (AZA and AZB) which are known to block the sodium channel Nav1.5, the hERG potassium channel and the L-type calcium channel. The sodium channel blockers bupivacaine, lidocaine, and the L-type calcium channel blocker nifedipine were used as reference substances. The experimental model was the gestational day (GD) 13 rat embryo cultured in vitro. In this model the embryonic heart activity can be directly observed, recorded and analyzed using computer assisted image analysis as it responds to the addition of test drugs. The effect on the heart was studied for a range of concentrations and for a duration up to 3 h. The results showed that AZA and AZB caused a concentration-dependent bradycardia of the embryonic heart and at high concentrations heart block. These effects were reversible on washout. In terms of potency to cause bradycardia the compounds were ranked AZB > bupivacaine > AZA > lidocaine > nifedipine. Comparison with results from previous studies with more specific ion channel blockers suggests that the primary effect of AZA and AZB was sodium channel blockage. The study shows that the short-term rat whole embryo culture (WEC) is a suitable system to detect substances hazardous to the embryonic heart. - Highlights: Study of the effect of sodium channel blocking drugs on embryonic heart function We used a modified method rat whole embryo culture with image analysis. The drugs tested caused a concentration dependent bradycardia and heart block. The effect of drugs acting on multiple ion channels is difficult to predict. This method may be used to detect cardiotoxicity in prenatal development.

  16. X-ray intravital microscopy for functional imaging in rat hearts using synchrotron radiation coronary microangiography

    SciTech Connect (OSTI)

    Umetani, K. [Japan Synchrotron Radiation Research Institute, SPring-8, Sayo-cho, Sayo-gun, Hyogo 679-5198 (Japan); Fukushima, K. [National Cerebral and Cardiovascular Center Hospital, Fujishirodai, Suita-shi, Osaka 565-8565 (Japan)

    2013-03-15T23:59:59.000Z

    An X-ray intravital microscopy technique was developed to enable in vivo visualization of the coronary, cerebral, and pulmonary arteries in rats without exposure of organs and with spatial resolution in the micrometer range and temporal resolution in the millisecond range. We have refined the system continually in terms of the spatial resolution and exposure time. X-rays transmitted through an object are detected by an X-ray direct-conversion type detector, which incorporates an X-ray SATICON pickup tube. The spatial resolution has been improved to 6 {mu}m, yielding sharp images of small arteries. The exposure time has been shortened to around 2 ms using a new rotating-disk X-ray shutter, enabling imaging of beating rat hearts. Quantitative evaluations of the X-ray intravital microscopy technique were extracted from measurements of the smallest-detectable vessel size and detection of the vessel function. The smallest-diameter vessel viewed for measurements is determined primarily by the concentration of iodinated contrast material. The iodine concentration depends on the injection technique. We used ex vivo rat hearts under Langendorff perfusion for accurate evaluation. After the contrast agent is injected into the origin of the aorta in an isolated perfused rat heart, the contrast agent is delivered directly into the coronary arteries with minimum dilution. The vascular internal diameter response of coronary arterial circulation is analyzed to evaluate the vessel function. Small blood vessels of more than about 50 {mu}m diameters were visualized clearly at heart rates of around 300 beats/min. Vasodilation compared to the control was observed quantitatively using drug manipulation. Furthermore, the apparent increase in the number of small vessels with diameters of less than about 50 {mu}m was observed after the vasoactive agents increased the diameters of invisible small blood vessels to visible sizes. This technique is expected to offer the potential for direct investigation of mechanisms of vascular dysfunctions.

  17. Iron supplementation at high altitudes induces inflammation and oxidative injury to lung tissues in rats

    SciTech Connect (OSTI)

    Salama, Samir A., E-mail: salama.3@buckeyemail.osu.edu [High Altitude Research Center, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia); Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11751 (Egypt); Department of Pharmacology and GTMR Unit, College of Clinical Pharmacy, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia); Omar, Hany A. [Department of Pharmacology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514 (Egypt); Maghrabi, Ibrahim A. [Department of Clinical Pharmacy, College of Clinical Pharmacy, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia); AlSaeed, Mohammed S. [Department of Surgery, College of Medicine, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia); EL-Tarras, Adel E. [High Altitude Research Center, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia)

    2014-01-01T23:59:59.000Z

    Exposure to high altitudes is associated with hypoxia and increased vulnerability to oxidative stress. Polycythemia (increased number of circulating erythrocytes) develops to compensate the high altitude associated hypoxia. Iron supplementation is, thus, recommended to meet the demand for the physiological polycythemia. Iron is a major player in redox reactions and may exacerbate the high altitudes-associated oxidative stress. The aim of this study was to explore the potential iron-induced oxidative lung tissue injury in rats at high altitudes (6000 ft above the sea level). Iron supplementation (2 mg elemental iron/kg, once daily for 15 days) induced histopathological changes to lung tissues that include severe congestion, dilatation of the blood vessels, emphysema in the air alveoli, and peribronchial inflammatory cell infiltration. The levels of pro-inflammatory cytokines (IL-1?, IL-6, and TNF-?), lipid peroxidation product and protein carbonyl content in lung tissues were significantly elevated. Moreover, the levels of reduced glutathione and total antioxidant capacity were significantly reduced. Co-administration of trolox, a water soluble vitamin E analog (25 mg/kg, once daily for the last 7 days of iron supplementation), alleviated the lung histological impairments, significantly decreased the pro-inflammatory cytokines, and restored the oxidative stress markers. Together, our findings indicate that iron supplementation at high altitudes induces lung tissue injury in rats. This injury could be mediated through excessive production of reactive oxygen species and induction of inflammatory responses. The study highlights the tissue injury induced by iron supplementation at high altitudes and suggests the co-administration of antioxidants such as trolox as protective measures. - Highlights: Iron supplementation at high altitudes induced lung histological changes in rats. Iron induced oxidative stress in lung tissues of rats at high altitudes. Iron increased the levels of IL-1?, IL-6 and TNF-? in lung tissues at high altitudes. Trolox alleviated the iron-induced histological and biochemical changes to the lungs.

  18. The postnatal development of the sex organs in prenatally and early postnatally irradiated male albino rats

    E-Print Network [OSTI]

    Ricks, Robert Clinton

    1964-01-01T23:59:59.000Z

    days of age and a sub- sequent regeneration between 105 and 185 days of age. Beaumont (1962) reported that in males receiving 100r X-rays on gestational day 17. 5, which corresponds very closely with day 18 irradiates in this study, it 41 appeared.... Bagg concludes, "the results so far indicate that gamma-ray irradiation is a physical agent adapted to the study of experimentally produced developmental arrests in mammalian embryos. " Hanson (1922) reported that male albino rats which were...

  19. Effects of chronic cadmium exposure on the conditioned reinforcing properties of morphine and fentanyl in rats

    E-Print Network [OSTI]

    Miller, Dennis K

    1997-01-01T23:59:59.000Z

    &M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved as to style and content by: ck R. Nation (C ir of Committee) Gerald D. Frye (Member) Paul J. Wellman (Member) Paul J. Wellman (Head of Department... the metal (Nation, Livermore, Bratton, & Schenk, 1996). A similar attenuation was shown with repeated cocaine exposure--the development of locomotor sensitization. Rats that received chronic cadmium exposure required more cocaine administration sessions...

  20. Effects of Nicotine Exposure on In Vitro Metabolism of Chlorpyrifos in Male Sprague-Dawley Rats

    SciTech Connect (OSTI)

    Lee, Sookwang; Busby, Andrea L.; Timchalk, Charles; Poet, Torka S.

    2009-01-30T23:59:59.000Z

    Chlorpyrifos (CPF) is a common organophosphate (OP) insecticide which is metabolized by CYP450s to the neurotoxic metabolite, chlorpyrifos-oxon (CPF-oxon) and a non-toxic metabolite, 3,5,6-trichloro-2-pyridinol (TCP). The objective of this study was to quantify the effect of repeated in vivo nicotine exposures on CPF in vitro metabolism and marker substrate activities in rats. Male Sprague-Dawley rats were dosed subcutaneously with 1 mg nicotine/kg/, for up to 10 days. Animals showed signs of cholinergic crisis after the initial nicotine doses, but exhibited adaptation after a couple days of treatment. Rats were sacrificed on selected days 4 or 24 hr after the last nicotine-treatment. While CYP450 reduced CO spectra were not different across the treatments, the single nicotine dose group showed a 2-fold increase in CYP2E1 marker substrate (p-nitrophenol) activity 24 hr after a single nicotine treatment compared to saline controls. Conversely, repeated nicotine treatments resulted in decreased EROD marker substrate activity 4 hr after the 7th day of treatment. CPF-oxon Vmax and Km did not show significant changes across the different nicotine treatment groups. The Vmax describing the metabolism of CPF to TCP was increased on all groups (days 1, 7, and 10) 24 hr after nicotine treatment but were unchanged 4 hr after nicotine treatment. Results of this in vitro study suggest that repeated nicotine exposure (i.e., from smoking) may result in altered metabolism of CPF. Future in vivo experiments based on these results will be conducted to ascertain the impact of in vivo nicotine exposures on CPF metabolism in rats.

  1. Some histological manifestations in the early postnatal vitamin B?? deficient albino rat

    E-Print Network [OSTI]

    Johnson, Elmer Marshall

    1955-01-01T23:59:59.000Z

    rats were slightly smeller in sine. Ilistologically the cortex was reduced in thickness ?nd therefore in total volume There was a considerable increase in intercellular space which was often filled with connective tissue and sometimes blood..., The renal corpus- cles were characterised by an increase in the space between Bowman's capsule and the glomerulus (I~'ig, 7). The loops of Henle in the medul- lary region showed reduoed lumina. The convoluted tubules (pr obably due to the fatty...

  2. Characterizing strain in the proximal rat tibia during electrical muscle stimulation

    E-Print Network [OSTI]

    Vyvial, Brent Aron

    2007-09-17T23:59:59.000Z

    of model EA-06-015SE-120 strain gage (23) . .................................... 16 Figure 8. Schematic diagram of the Wheatstone bridge circuit (23) ................................. 17 Figure 9. Diagram of a hindlimb unloaded rat (17... of the gage increases due to a reduction in cross-sectional area of the grid elements; however, the change in resistance is too small to measure directly. Therefore, the gage is connected to three known resistors in a Wheatstone Bridge circuit, to which...

  3. Rat lymphoma cell bioassay for prolactin: observations on its use and comparison with radioimmunoassay

    SciTech Connect (OSTI)

    Dawson, D.M.; Sensui, N.; Haisenleder, D.H.; Gala, R.R.

    1982-12-27T23:59:59.000Z

    The rat Nb/sub 2/ node lymphoma cell bioassay (BA) for prolactin (PRL) was validated for use in our laboratories. During the course of this validation we observed that rat prolactin (NIAMDD-RP-1) stimulated cell division by as much as 16.5 fold over the range of 0.04 to 40.0 ng/ml at the end of 72 hours of incubation. We also observed a dose related increase in the size of the lymphoma cells. Prolactin concentrations in rat plasma, serum, anterior pituitary (AP) homogenates and milk were measured by both radioimmunoassay (RIA) and BA. In individual BA's there was parallelism between samples and standard; but when several dilutions of the same plasma and pituitary homogenates were assayed repeatedly, higher PRL levels were consistently observed for the more concentrated samples. At low or moderate levels of plasma PRL there was excellent agreement between RIA and BA; however, at high levels plasma PRL bioactivity exceeded radioimmunoactivity by a small, but significant, amount. A comparison of pituitary PRL concentrations measured by RIA and BA were in good agreement when homogenization was done at pH 10.6. However, when homogenization was done at pH 7.6, slightly but significantly more PRL was extracted when assayed by BA than when assayed by RIA.

  4. Physiological effects following administration of Citrus aurantium for 28 days in rats

    SciTech Connect (OSTI)

    Hansen, Deborah K., E-mail: deborah.hansen@fda.hhs.gov [Division of Personalized Nutrition and Medicine, U.S. FDA/NCTR, 3900 NCTR Rd., Jefferson, AR 72079 (United States); George, Nysia I. [Division of Personalized Nutrition and Medicine, U.S. FDA/NCTR, 3900 NCTR Rd., Jefferson, AR 72079 (United States)] [Division of Personalized Nutrition and Medicine, U.S. FDA/NCTR, 3900 NCTR Rd., Jefferson, AR 72079 (United States); White, Gene E. [Toxicological Pathology Associates, 3900 NCTR Rd., Jefferson, AR 72079 (United States)] [Toxicological Pathology Associates, 3900 NCTR Rd., Jefferson, AR 72079 (United States); Pellicore, Linda S. [Office of New Drugs, U.S. FDA/Center for Drug Evaluation and Research, 10903 New Hampshire Ave., Silver Spring, MD 20903 (United States)] [Office of New Drugs, U.S. FDA/Center for Drug Evaluation and Research, 10903 New Hampshire Ave., Silver Spring, MD 20903 (United States); Abdel-Rahman, Ali; Fabricant, Daniel [Office of Nutrition, Labeling and Dietary Supplements, U.S. FDA/Center for Food Safety and Nutrition, HFS-810, College Park, MD 20740 (United States)] [Office of Nutrition, Labeling and Dietary Supplements, U.S. FDA/Center for Food Safety and Nutrition, HFS-810, College Park, MD 20740 (United States)

    2012-06-15T23:59:59.000Z

    Background: Since ephedra-containing dietary supplements were banned from the US market, manufacturers changed their formulations by eliminating ephedra and replacing with other botanicals, including Citrus aurantium, or bitter orange. Bitter orange contains, among other compounds, synephrine, a chemical that is chemically similar to ephedrine. Since ephedrine may have cardiovascular effects, the goal of this study was to investigate the cardiovascular effects of various doses of bitter orange extract and pure synephrine in rats. Method: Female SpragueDawley rats were dosed daily by gavage for 28 days with synephrine from two different extracts. One extract contained 6% synephrine, and the other extract contained 95% synephrine. Doses were 10 or 50 mg synephrine/kg body weight from each extract. Additionally, caffeine was added to these doses, since many dietary supplements also contain caffeine. Telemetry was utilized to monitor heart rate, blood pressure, body temperature and QT interval in all rats. Results and conclusion: Synephrine, either as the bitter orange extract or as pure synephrine, increased heart rate and blood pressure. Animals treated with 95% synephrine showed minimal effects on heart rate and blood pressure; more significant effects were observed with the bitter orange extract suggesting that other components in the botanical can alter these physiological parameters. The increases in heart rate and blood pressure were more pronounced when caffeine was added. None of the treatments affected uncorrected QT interval in the absence of caffeine.

  5. Intestinal permeability and bacterial translocation following small bowel transplantation in the rat

    SciTech Connect (OSTI)

    Grant, D.; Hurlbut, D.; Zhong, R.; Wang, P.Z.; Chen, H.F.; Garcia, B.; Behme, R.; Stiller, C.; Duff, J. (University of Western Ontario (Canada))

    1991-08-01T23:59:59.000Z

    In addition to its role in absorbing nutrients, the intestinal mucosa provides an important barrier against toxins and bacteria in the bowel lumen. The present study evaluated gut barrier function following orthotopic (in continuity) intestinal grafting in rats. Graft histology, intestinal permeability, and bacterial translocation to the grafted mesenteric lymph nodes, the host's liver, and the host's spleen were assessed on the 3rd, 5th, and 7th postoperative days. The study group received no immunosuppression after allotransplantation. The two control groups included rats with isografts and rats with cyclosporine-treated allografts. On the 7th POD, the study animals had moderate transmural inflammation due to rejection, with normal histology in the isografts and CsA-treated allografts; increased intestinal permeability, measured by urinary excretion of oral 51Cr-EDTA (P less than 0.01); and increased number of bacteria in the MLN and spleen (P less than 0.05). The number of bacteria in the MLN and spleen of the study group positively correlated with the changes in intestinal permeability (P less than 0.05). Rejection of the orthotopic intestinal graft leads to increased intestinal permeability and bacterial translocation from the lumen of the graft to the host's reticuloendothelial system. Measures to improve gut barrier function and antibiotic therapy during rejection episodes may help reduce the incidence of septic complications after intestinal grafting.

  6. Immunocompetent syngeneic cotton rat tumor models for the assessment of replication-competent oncolytic adenovirus

    SciTech Connect (OSTI)

    Steel, Jason C.; Morrison, Brian J.; Mannan, Poonam [Cancer Gene Therapy Section, Metabolism Branch, Center for Cancer Research, National Cancer Institute, Mark O. Hatfield Clinical Research Center, Room 4-5330, 10 Center Drive, Bethesda, MD 20892-1457, National Institutes of Health, Maryland (United States); Abu-Asab, Mones S. [Ultrastructural Pathology, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Maryland (United States); Wildner, Oliver [Department of Molecular and Medical Virology, Ruhr University Bochum (Germany); Miles, Brian K.; Yim, Kevin C. [Virion Systems, Inc., Rockville, Maryland (United States); Ramanan, Vijay [Cancer Gene Therapy Section, Metabolism Branch, Center for Cancer Research, National Cancer Institute, Mark O. Hatfield Clinical Research Center, Room 4-5330, 10 Center Drive, Bethesda, MD 20892-1457, National Institutes of Health, Maryland (United States); Prince, Gregory A. [Virion Systems, Inc., Rockville, Maryland (United States); Morris, John C. [Cancer Gene Therapy Section, Metabolism Branch, Center for Cancer Research, National Cancer Institute, Mark O. Hatfield Clinical Research Center, Room 4-5330, 10 Center Drive, Bethesda, MD 20892-1457, National Institutes of Health, Maryland (United States)], E-mail: jmorris@mail.nih.gov

    2007-12-05T23:59:59.000Z

    Oncolytic adenoviruses as a treatment for cancer have demonstrated limited clinical activity. Contributing to this may be the relevance of preclinical animal models used to study these agents. Syngeneic mouse tumor models are generally non-permissive for adenoviral replication, whereas human tumor xenograft models exhibit attenuated immune responses to the vector. The cotton rat (Sigmodon hispidus) is susceptible to human adenovirus infection, permissive for viral replication and exhibits similar inflammatory pathology to humans with adenovirus replicating in the lungs, respiratory passages and cornea. We evaluated three transplantable tumorigenic cotton rat cell lines, CCRT, LCRT and VCRT as models for the study of oncolytic adenoviruses. All three cells lines were readily infected with adenovirus type-5-based vectors and exhibited high levels of transgene expression. The cell lines supported viral replication demonstrated by the induction of cytopathogenic effect (CPE) in tissue culture, increase in virus particle numbers and assembly of virions seen on transmission electron microscopy. In vivo, LCRT and VCRT tumors demonstrated delayed growth after injection with replicating adenovirus. No in vivo antitumor activity was seen in CCRT tumors despite in vitro oncolysis. Adenovirus was also rapidly cleared from the CCRT tumors compared to LCRT and VCRT tumors. The effect observed with the different cotton rat tumor cell lines mimics the variable results of human clinical trials highlighting the potential relevance of this model for assessing the activity and toxicity of oncolytic adenoviruses.

  7. Cardiac catecholamines in rats fed copper deficient or copper adequate diets containing fructose or starch

    SciTech Connect (OSTI)

    Scholfield, D.J.; Fields, M.; Beal, T.; Lewis, C.G.; Behall, K.M. (Dept. og Agriculture, Beltsville, MD (USA))

    1989-02-09T23:59:59.000Z

    The symptoms of copper (Cu) deficiency are known to be more severe when rats are fed a diet with fructose (F) as the principal carbohydrate. Mortality, in males, due to cardiac abnormalities usually occurs after five weeks of a 62% F, 0.6 ppm Cu deficient diet. These effects are not observed if cornstarch (CS) is the carbohydrate (CHO) source. Studies with F containing diets have shown increased catecholamine (C) turnover rates while diets deficient in Cu result in decreased norepinephrine (N) levels in tissues. Dopamine B-hydroxylase (EC 1.14.17.1) is a Cu dependent enzyme which catalyzes the conversion of dopamine (D) to N. An experiment was designed to investigate the effects of CHO and dietary Cu on levels of three C in cardiac tissue. Thirty-two male and female Sprague-Dawley rats were fed Cu deficient or adequate diets with 60% of calories from F or CS for 6 weeks. N, epinephrine (E) and D were measured by HPLC. Statistical analysis indicates that Cu deficiency tends to decrease N levels, while having the reverse effect on E. D did not appear to change. These findings indicate that Cu deficiency but not dietary CHO can affect the concentration of N and E in rat cardiac tissue.

  8. 30 UWBUSINESS by Ed KromEr

    E-Print Network [OSTI]

    Kaminsky, Werner

    ." Penny Arcade's readership was already impressive and impassioned. And growing like kudzu. But given

  9. for Pulsed Power & erElectronics|Texas

    E-Print Network [OSTI]

    Gelfond, Michael

    University began in the early 70's with stud- ies in high beta, controlled thermonuclear fusion accelerators, nuclear fusion, nuclear weap- ons effects and lightning simulations, industrial manufacturing

  10. Final Technical Report, DOE/ER/64323

    SciTech Connect (OSTI)

    Valocchi, Albert J. [University of Illinois, Dept of Civil & Environ Engr] University of Illinois, Dept of Civil & Environ Engr

    2013-06-05T23:59:59.000Z

    The DOE SciDAC program funded a team that developed PFLOTRAN, the next-generation (â??peta-scaleâ??) massively parallel, multiphase, multicomponent reactive flow and transport code. These codes are required to improve understanding and risk management of subsurface contaminant migration and geological sequestration of carbon dioxide. The important fate and transport processes occurring in the subsurface span a wide range of spatial and temporal scales, and involve nonlinear interactions among many different chemical constituents. Due to the complexity of this problem, modeling subsurface processes normally requires simplifying assumptions. However, tools of advanced scientific computing that have been used in other areas such as energy and materials research can also help address challenging problems in the environmental and geoscience fields. The overall project was led by Los Alamos National Laboratory and included Argonne, Oak Ridge and Pacific Northwest National Laboratories, in addition to the University of Illinois. This report summarizes the results of the research done at the University of Illinois, which focused on improvements to the underlying physical and computational modeling of certain transport and mixing processes.

  11. for Multir ovi eliver er vice

    E-Print Network [OSTI]

    Shaikh, Anees

    in s s an s m n an an s an n s m s i mains a a sin i as primary i i ma in a nsis s s m s a i s n a ma s n i i s s s m i s a m i i a i s a n s as a n n is i i n s s i s m i in sin is ma imi s n ima i a a i a s a a i ima

  12. Explorewww.trentu.ca/ers Environmental

    E-Print Network [OSTI]

    Fox, Michael

    environmental research, natural resource conservation, environmental planning and assessment, water and waste management, and social advocacy. Why Trent? Be part of the Canadian standard for environmental inquiry Learn such as environmental law and forest management Study abroad and take advantage of research placements Enjoy

  13. Final Scientific Report for ER41087

    SciTech Connect (OSTI)

    Hiller, John R. [University of Minnesota-Duluth] [University of Minnesota-Duluth

    2013-08-23T23:59:59.000Z

    The primary focus of the work was the development of methods for the nonperturbative solution of quantum chromodynamics (QCD) in a form that yields wave functions for the eigenstates, from which hadronic properties can be computed. The principal approach was to use a light-front Hamiltonian formulation. In light-front coordinates, t+z/c plays the role of time, with t the ordinary time, z a space direction, and c the speed of light. This leads to a relativistic formulation that retains useful characteristics of nonrelativistic treatments. A bound state of many constituents can be represented by wave functions that define probabilities for each possible arrangement of internal momenta. These functions satisfy integral equations that can be approximated numerically to yield a matrix representation. The matrix problem can be solved by iterative methods. The approximate wave functions can then be used to compute properties of the bound state. Methods have been developed for model theories and gauge theories, including quantum electrodynamics and theories that are supersymmetric. The work has required the development of new numerical algorithms and computer codes for singular integral equations and eigenvalue problems. A key aspect of the work is the construction of practical procedures for nonperturbative regularization and renormalization. Two methods of regularization have been studied. One is the addition of heavy Pauli--Villars (PV) particles to the Lagrangian, with their metrics and couplings tuned to provide the necessary cancellations in the regularization. The other method of regularization is the addition of supersymmetric partners, to extend a theory to a supersymmetric form. The supersymmetric theories were solved by the supersymmetric discrete light-cone quantization (SDLCQ) method. The most significant accomplishments of the project were the SDLCQ calculation of direct evidence for a Maldacena duality conjecture, construction of a practical light-front quantization for QED in an arbitrary covariant gauge, and invention of the light-front coupled-cluster method, designed to eliminate the need for Fock-space truncations.

  14. Final Report for DOE Award ER25756

    SciTech Connect (OSTI)

    Kesselman, Carl

    2014-11-17T23:59:59.000Z

    The SciDAC-funded Center for Enabling Distributed Petascale Science (CEDPS) was established to address technical challenges that arise due to the frequent geographic distribution of data producers (in particular, supercomputers and scientific instruments) and data consumers (people and computers) within the DOE laboratory system. Its goal is to produce technical innovations that meet DOE end-user needs for (a) rapid and dependable placement of large quantities of data within a distributed high-performance environment, and (b) the convenient construction of scalable science services that provide for the reliable and high-performance processing of computation and data analysis requests from many remote clients. The Center is also addressing (c) the important problem of troubleshooting these and other related ultra-high-performance distributed activities from the perspective of both performance and functionality

  15. ChaptEr 1 Earth's Closest Neighbors

    E-Print Network [OSTI]

    Landweber, Laura

    , but most of it is in the form of very small dust particles or very small stones. Much of this dust and sand cause impressive fireball events, our atmosphere prevents almost all of them from reaching the ground missile launch events and nuclear explosions. Mr. S. B. Semenov Gets Blown off His Porch Allow me

  16. E.R. Daviesa , M. Atiquzzamanb

    E-Print Network [OSTI]

    Atiquzzaman, Mohammed

    . Then there are the variants on the main projection-based transforms theme: how useful and different are structural indexing, geometric hashing, projection-based transforms, and indeed, the origi- nal Hough transform (HT)? And has. Conventional HTs find con- siderable difficulty with such images, missing some over- lapping components

  17. DOE/ER--0547T DE92

    Office of Scientific and Technical Information (OSTI)

    Office, Environment, Safety, Ikislmstl A r'a,v 1. tml (;, Lo,s' A htmos Natiomtl and Health Division, Environmental Programs Laloratm'v, l.t,.l)i'lI.,A..t11(.-86237(), l,os...

  18. Microsoft Word - westwater_er.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: VegetationEquipment SurfacesResource Program PreliminaryA TrimodalRECENTMicrophysicalRobert D.2004 North

  19. NASA is operating two Lockheed ER-2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Opticalhttp://www.fnal.gov/directorate/nalcal/nalcal02_07_05_files/nalcal.gif Directorate - Events -Science (SC) 8is

  20. DOE/ER/06035--7

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed Newcatalyst phases onOrganizationElectronic Reading2Q)382 THE HUMAN GENOME2