Sample records for rat neth er

  1. Large-scale Nanostructure Simulations from X-ray Scattering Data On Graphics Processor Clusters

    E-Print Network [OSTI]

    Sarje, Abhinav

    2012-01-01T23:59:59.000Z

    X-ray Scattering Data On Graphics Processor Clusters Abhinavaccelerators. General purpose graphics processors o?er ?nethe form factors on graphics processors. Form Factor Kernel

  2. OoEr

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA group currentBradleyTableSelling7 AugustAFRICAN .METALS~ c3ppY-.I ' Y{OoEr 1325.8

  3. Estrogen receptor alpha 36 (ER-36) and other novel spliced ERs are widely expressed in ER-66-negative breast tumors

    E-Print Network [OSTI]

    of ER are examined using qPCR in ER-negative cell lines MCF7 MDA-MB-231 SKBR3 MCF7/218 (MC-20)(F-10-66-neagtive SKBR3 cells and ER-66-positive MCF7/218cells. A novel spliced form of ER is detected by WB using anti-ER(MC-20) antibody in ER-66- negative MDA-MB-231 and SKBR3 cell lines. 4. A novel

  4. Protein folding in the ER.

    SciTech Connect (OSTI)

    Stevens, F. J.; Argon, Y.; Biosciences Division; Univ. of Chicago

    1999-10-01T23:59:59.000Z

    The endoplasmic reticulum (ER) is a major protein folding compartment for secreted, plasma membrane and organelle proteins. Each of these newly-synthesized polypeptides folds in a deterministic process, affected by the unique conditions that exist in the ER. An understanding of protein folding in the ER is a fundamental biomolecular challenge at two levels. The first level addresses how the amino acid sequence programs that polypeptide to efficiently arrive at a particular fold out of a multitude of alternatives, and how different sequences obtain similar folds. At the second level are the issues introduced by folding not in the cytosol, but in the ER, including the risk of aggregation in a molecularly crowded environment, accommodation of post-translational modifications and the compatibility with subsequent intracellular trafficking. This review discusses both the physicochemical and cell biological constraints of folding, which are the challenges that the ER molecular chaperones help overcome.

  5. Energy and Society (ER100/PP184/ER200/PP284) Topics: PV, Wind, environmental justice

    E-Print Network [OSTI]

    Kammen, Daniel M.

    the levelized cost of electricity. [5 points] #12;Energy and Society (ER100/PP184/ER200/PP284) Topics: PV, Wind Points: 102 [ER100/PP184], 113 [ER200/PP284] - 2 - 2. Wind Power Analysis [18 points grad, 10 pointsEnergy and Society (ER100/PP184/ER200/PP284) Topics: PV, Wind, environmental justice Due Nov. 21

  6. BIOENERGI ER BLEVET MODERNE 4DECEMBER 2003

    E-Print Network [OSTI]

    , biogas og bioethanol. Bioenergi er den eneste vedvarende energikilde, der findes i fast, flydende og

  7. Energy and Society ER100/PPC184/ER200/PPC284, Fall 2014

    E-Print Network [OSTI]

    Kammen, Daniel M.

    of the process. If the article comes from New York Times, Wall Street Journal, Economist, Time, etc Timeliness1 Energy and Society ER100/PPC184/ER200/PPC284, Fall 2014 Problem Set #2 Total Points: 100 for ER100/PPC184 120 for ER200/PPC284 Topics covered: Energy and development, Combustion, Exponential growth

  8. af biobraendsler er: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Society (ER100PP184ER200PP284) Topics: Personal energy audit, the grid, nuclear, fracking Renewable Energy Websites Summary: Energy and Society (ER100PP184ER200PP284)...

  9. alleviates er stress: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Society (ER100PP184ER200PP284) Topics: Personal energy audit, the grid, nuclear, fracking Renewable Energy Websites Summary: Energy and Society (ER100PP184ER200PP284)...

  10. Tank 241-ER-311, grab samples, ER311-98-1, ER311-98-2, ER311-98-3 analytical results for the final report

    SciTech Connect (OSTI)

    FULLER, R.K.

    1999-02-24T23:59:59.000Z

    This document is the final report for catch tank 241-ER-311 grab samples. Three grab samples ER311-98-1, ER311-98-2 and ER311-98-3 were taken from East riser of tank 241-ER-311 on August 4, 1998 and received by the 222-S Laboratory on August 4, 1998. Analyses were performed in accordance with the Compatibility Grab Sampling and Analysis Plan (TSAP) (Sasaki, 1998)and the Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) (Mulkey and Miller, 1997). The analytical results are presented in the data summary report (Table 1). No notification limits were exceeded.

  11. er 1, 2012 (v ctrical Engi

    E-Print Network [OSTI]

    Meyers, Steven D.

    digital c one or m above a dependin Deadline Contac er 1, 2012 (v searc Post-Doct ctrical Engi y invites

  12. Energy and Society (ER100/PP184/ER200/PP284) Topics: PV, Wind, environmental justice

    E-Print Network [OSTI]

    Kammen, Daniel M.

    Energy and Society (ER100/PP184/ER200/PP284) Topics: PV, Wind, environmental justice Due Nov. 21) Topics: PV, Wind, environmental justice Due Nov. 21, in class, or before 5pm outside 310 Barrows Fall

  13. Solstrling er temaet i denne boka. Alt liv er avhengig av solstrling sola gir liv, og sola er

    E-Print Network [OSTI]

    Sahay, Sundeep

    #12;Solstråling er temaet i denne boka. Alt liv er avhengig av solstråling ­ sola gir liv, og sola solstrålingens betydning for vår helse og gi en naturfaglig bakgrunn for hvordan en bør styre sine solvaner. Sola de viktigste, og at det innebærer en større risiko hvis en ikke lar sola skinne på kroppen. I

  14. Energy and Society ER100/PPC184/ER200/PPC284, Fall 2014

    E-Print Network [OSTI]

    Kammen, Daniel M.

    countries with average annual per capita energy consumption rates under 1 TOE)? [5 points] 2. Exponential, poverty and gender The chapter "Energy and Poverty" from the 2002 World Energy Outlook, states "...theEnergy and Society ER100/PPC184/ER200/PPC284, Fall 2014 Problem Set #2 Total Points: 100 for ER100

  15. Ternary Dy-Er-Al magnetic refrigerants

    DOE Patents [OSTI]

    Gschneidner, K.A. Jr.; Takeya, Hiroyuki

    1995-07-25T23:59:59.000Z

    A ternary magnetic refrigerant material comprising (Dy{sub 1{minus}x}Er{sub x})Al{sub 2} for a magnetic refrigerator using the Joule-Brayton thermodynamic cycle spanning a temperature range from about 60K to about 10K, which can be adjusted by changing the Dy to Er ratio of the refrigerant. 29 figs.

  16. Ternary Dy-Er-Al magnetic refrigerants

    DOE Patents [OSTI]

    Gschneidner, Jr., Karl A. (Ames, IA); Takeya, Hiroyuki (Ibaraki, JP)

    1995-07-25T23:59:59.000Z

    A ternary magnetic refrigerant material comprising (Dy.sub.1-x Er.sub.x)Al.sub.2 for a magnetic refrigerator using the Joule-Brayton thermodynamic cycle spanning a temperature range from about 60K to about 10K, which can be adjusted by changing the Dy to Er ratio of the refrigerant.

  17. Characterization of the ER stress checkpoint in mammalian cells

    E-Print Network [OSTI]

    Chen, Meifan

    2011-01-01T23:59:59.000Z

    role in oxidative protein folding in the endoplasmiccellular demand for protein folding and ER capacity has beenlipids. To ensure proper protein folding within the ER, the

  18. In vitro analysis of ER-associated protein degradation

    E-Print Network [OSTI]

    Garza, Renee Marie

    2008-01-01T23:59:59.000Z

    required for ER-associated degradation. Nat Cell Biol, 3,Cue1p in ubiquitination and degradation at the ER surface.1999) Measuring protein degradation with green fluorescent

  19. An ab initio-based Er–He interatomic potential in hcp Er

    SciTech Connect (OSTI)

    Yang, Li; ye, Yeting; Fan, K. M.; Shen, Huahai; Peng, Shuming; Long, XG; Zhou, X. S.; Zu, Xiaotao; Gao, Fei

    2014-09-01T23:59:59.000Z

    We have developed an empirical erbium-helium (Er-He) potential by fitting to the results calculated from ab initio method. Based on the electronic hybridization between Er and He atoms, an s-band model, along with a repulsive pair potential, has been derived to describe the Er-He interaction. The atomic configurations and the formation energies of single He defects, small He interstitial clusters (Hen) and He-vacancy (HenV ) clusters obtained by ab initio calculations are used as the fitting database. The binding energies and relative stabilities of the HnVm clusters are studied by the present potential and compared with the ab initio calculations. The Er-He potential is also applied to study the migration of He in hcp-Er at different temperatures, and He clustering is found to occur at 600 K in hcp Er crystal, which may be due to the anisotropic migration behavior of He interstitials.

  20. Environmental release summary (ERS) database CY 1997

    SciTech Connect (OSTI)

    Gleckler, B.P.

    1998-07-01T23:59:59.000Z

    This report discusses the Environmental Release Summary (ERS) database. The current needs of the Effluent and Environmental database is continually modified to fulfill monitoring (EEM) program (managed by Waste Management Federal Services of Hanford, Incorporated, Air and Water Services Organization). Changes are made to accurately calculate current releases, to affect how past releases are calculated. This document serves as a snap-shot of the database and software for the CY-1997 data and releases. This document contains all of the relevant data for calculating radioactive-airborne and liquid effluent. The ERS database is the official repository for the CY-1997 ERS release reports and the settings used to generate those reports. As part of the Tri-Party Agreement, FDH is committed to provide a hard copy of the ERS database for Washington State Department of Ecology, upon request. This document also serves as that hard copy for the last complete calendar year.

  1. Low temperature properties of some Er-rich intermetallic compounds

    SciTech Connect (OSTI)

    K.A. Gshneidner,jr; A.O. Pecharsky; L.Hale; V.K. Pecharsky

    2004-09-30T23:59:59.000Z

    The low temperature volumetric heat capacity ({approx}3.5 to 350 K) and magnetic susceptibility ({approx}4 to 320 K) of Er{sub 3}Rh, Er{sub 3}Ir, Er{sub 3}Pt, Er{sub 2}Al, and Er{sub 2}Sn have been measured. All of the compounds order antiferromagnetically (or ferrimagnetically), and most exhibit more than one magnetic ordering transition. The volumetric heat capacities in general are smaller than those of the prototype magnetic regenerator materials, except for Er{sub 3}Ir in the 12 to 14 K temperature range.

  2. Kenya (Rpublique du) Admission 1 er

    E-Print Network [OSTI]

    Montréal, Université de

    2014-04-14 Kenya (République du) Admission 1 er cycle Programmes à capacité d'accueil limitée : complément d'informations Seuils requis selon les programmes Détails sur le test Kenya Certificate

  3. Explorewww.trentu.ca/ers Environmental

    E-Print Network [OSTI]

    Fox, Michael

    environmental research, natural resource conservation, environmental planning and assessment, water and wasteExplorewww.trentu.ca/ers Explore Your Passion Environmental and Resource Studies/Science. Trent. You. #12;LEARNING TO MAKE A WORLD OF DIFFERENCE.TM Career Conscious Skills in environmental studies

  4. DOE/ER-0214 February 1985

    E-Print Network [OSTI]

    DOE/ER-0214 Magnetic Program Fusion Plan February 1985 U.S. Department of Energy Office of Energy Research Washington, D.C. 20585 #12;U.S. DEPARTMENT OF ENERGY Office of Energy Research February 1985, available resources, and the nation's need for future energy sources. #12;PREFACE During the past few years

  5. Correlations in Multiparticle Markus Ringn' er

    E-Print Network [OSTI]

    Ringnér, Markus

    Production Markus Ringn' er Department of Theoretical Physics Lund University, Sweden Thesis for the degree, with the permission of the Faculty of Mathematics and Natural Sciences of Lund University, for public criticism field which should survive fragmentation is presented. Inspired by the Feynman­Wilson gas analogy

  6. Unique ER Cistromes Control Cell Type-Specific Gene Regulation

    E-Print Network [OSTI]

    Brown, Myles

    -specific E2 regulation of gene expression in MCF7 and U2OS- ER cells, we compared the ER binding sites on DNA a critical role in defining the ER cistrome in MCF7 cells, it is not expressed in U2OS-ER cells, and forkhead-specific effects, however, remains to be explained. We have compared the gene expres- sion profile of the MCF7

  7. The ER-associated degradation (ERAD) pathway directs ubiquitin-mediated degradation of a variety of ER-associated

    E-Print Network [OSTI]

    Hampton, Randy

    476 The ER-associated degradation (ERAD) pathway directs ubiquitin-mediated degradation carboxypeptidase Y DER degradation in the ER ERAD ER-associated degradation FPP farnesyl pyrophosphate HMGR 3-hydroxy 3-methylglutaryl-CoA reductase HRD HMG-CoA reductase degradation SCAP SREBP cleavage

  8. ER-12-1 completion report

    SciTech Connect (OSTI)

    Russell, C.E.; Gillespie, D.; Cole, J.C.; Drellack, S.L. [and others

    1996-12-01T23:59:59.000Z

    The objective of drillhole ER-12-1 was to determine the hydrogeology of paleozoic carbonate rocks and of the Eleana Formation, a regional aquitard, in an area potentially downgradient from underground nuclear testing conducted in nearby Rainier Mesa. This objective was addressed through the drilling of well ER-12-1 at N886,640.26 E640,538.85 Nevada Central Coordinates. Drilling of the 1094 m (3588 ft) well began on July 19, 1991 and was completed on October 17, 1991. Drilling problems included hole deviation and hole instability that prevented the timely completion of this borehole. Drilling methods used include rotary tri-cone and rotary hammer drilling with conventional and reverse circulation using air/water, air/foam (Davis mix), and bentonite mud. Geologic cuttings and geophysical logs were obtained from the well. The rocks penetrated by the ER-12-1 drillhole are a complex assemblage of Silurian, Devonian, and Mississippian sedimentary rocks that are bounded by numerous faults that show substantial stratigraphic offset. The final 7.3 m (24 ft) of this hole penetrated an unusual intrusive rock of Cretaceous age. The geology of this borehole was substantially different from that expected, with the Tongue Wash Fault encountered at a much shallower depth, paleozoic rocks shuffled out of stratigraphic sequence, and the presence of an altered biotite-rich microporphyritic igneous rock at the bottom of the borehole. Conodont CAI analyses and rock pyrolysis analyses indicate that the carbonate rocks in ER-12-1, as well as the intervening sheets of Eleana siltstone, have been thermally overprinted following movement on the faults that separate them. The probable source of heat for this thermal disturbance is the microporphyritic intrusion encountered at the bottom of the hole, and its age establishes that the major fault activity must have occurred prior to 102.3+0.5 Ma (middle Cretaceous).

  9. ER85773 | netl.doe.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power AdministrationField Campaign:INEA :Work4/11 ENVIROISSUES PAGEMesoscopy andAbout UsER85773

  10. DOE/ER--0547T DE92

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItem Not Found Item Not Found The itemAIR57451 Clean Energy5655994DP-1513 . D iER--0547T

  11. Energy and Society ER100/PPC184/ER200/PPC284, Fall 2014

    E-Print Network [OSTI]

    Kammen, Daniel M.

    CO2 (in $/ton CO2) over time. Assume a GHG emission rate of 530g CO2/kWh from the natural gas power CO2 for the society (as represented by these four entities) on an annual basis. A net benefit/PP184 120 for ER200/PP284 Topics covered: NPV, Energy efficiency, Electricity grid, Learning curve 1

  12. An Improved Algorithm for Quanti er Elimination Over Real Closed ...

    E-Print Network [OSTI]

    assumption that each polynomial in the input depend ..... We call this procedure uniform quanti er elim- .... and describe the inputs, outputs and complexities of.

  13. ER85357_Phase2_Eltron | netl.doe.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Unconventional High Temperature Nanofiltration for Produced Water Treatment Last Reviewed 6252013 DE-10ER85357 Goal The project goal is to further develop a proprietary,...

  14. RisNyt NO2 2005 1313 Demand response er som at kbe benzin

    E-Print Network [OSTI]

    RisøNyt NO2 2005 1313 Demand response er som at købe benzin når den er billigst Af Leif Sønderberg tankstationen og købe mest muligt benzin når prisen er lavest. Sådan er Demand Response, som vi også vil opleve at ændre på dette er Demand Response (DR), hvor man inden for korte tids- intervaller skal agere på

  15. Final Technical Report for Award # ER64999

    SciTech Connect (OSTI)

    Metcalf, William W. [University of Illinois

    2014-10-08T23:59:59.000Z

    This report provides a summary of activities for Award # ER64999, a Genomes to Life Project funded by the Office of Science, Basic Energy Research. The project was entitled "Methanogenic archaea and the global carbon cycle: a systems biology approach to the study of Methanosarcina species". The long-term goal of this multi-investigator project was the creation of integrated, multiscale models that accurately and quantitatively predict the role of Methanosarcina species in the global carbon cycle under dynamic environmental conditions. To achieve these goals we pursed four specific aims: (1) genome sequencing of numerous members of the Order Methanosarcinales, (2) identification of genomic sources of phenotypic variation through in silico comparative genomics, (3) elucidation of the transcriptional networks of two Methanosarcina species, and (4) development of comprehensive metabolic network models for characterized strains to address the question of how metabolic models scale with genetic distance.

  16. Ozone induces glucose intolerance and systemic metabolic effects in young and aged brown Norway rats

    SciTech Connect (OSTI)

    Bass, V. [Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Gordon, C.J.; Jarema, K.A.; MacPhail, R.C. [Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Cascio, W.E. [Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Phillips, P.M. [Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Ledbetter, A.D.; Schladweiler, M.C. [Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Andrews, D. [Research Cores Unit, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Miller, D. [Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC (United States); Doerfler, D.L. [Research Cores Unit, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Kodavanti, U.P., E-mail: kodavanti.urmila@epa.gov [Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States)

    2013-12-15T23:59:59.000Z

    Air pollutants have been associated with increased diabetes in humans. We hypothesized that ozone would impair glucose homeostasis by altering insulin signaling and/or endoplasmic reticular (ER) stress in young and aged rats. One, 4, 12, and 24 month old Brown Norway (BN) rats were exposed to air or ozone, 0.25 or 1.0 ppm, 6 h/day for 2 days (acute) or 2 d/week for 13 weeks (subchronic). Additionally, 4 month old rats were exposed to air or 1.0 ppm ozone, 6 h/day for 1 or 2 days (time-course). Glucose tolerance tests (GTT) were performed immediately after exposure. Serum and tissue biomarkers were analyzed 18 h after final ozone for acute and subchronic studies, and immediately after each day of exposure in the time-course study. Age-related glucose intolerance and increases in metabolic biomarkers were apparent at baseline. Acute ozone caused hyperglycemia and glucose intolerance in rats of all ages. Ozone-induced glucose intolerance was reduced in rats exposed for 13 weeks. Acute, but not subchronic ozone increased ?{sub 2}-macroglobulin, adiponectin and osteopontin. Time-course analysis indicated glucose intolerance at days 1 and 2 (2 > 1), and a recovery 18 h post ozone. Leptin increased day 1 and epinephrine at all times after ozone. Ozone tended to decrease phosphorylated insulin receptor substrate-1 in liver and adipose tissues. ER stress appeared to be the consequence of ozone induced acute metabolic impairment since transcriptional markers of ER stress increased only after 2 days of ozone. In conclusion, acute ozone exposure induces marked systemic metabolic impairments in BN rats of all ages, likely through sympathetic stimulation. - Highlights: • Air pollutants have been associated with increased diabetes in humans. • Acute ozone exposure produces profound metabolic alterations in rats. • Age influences metabolic risk factors in aging BN rats. • Acute metabolic effects are reversible and repeated exposure reduces these effects. • Ozone metabolic effects are only slightly exacerbated in geriatric rats.

  17. Comparative activation of estrogen receptor alpha (er alpha) by endocrine disruptors

    E-Print Network [OSTI]

    Wu, Fei

    2009-05-15T23:59:59.000Z

    -dependent,. These results demonstrate that various ER ligands differentially activate ER? in breast cancer cells and transgenic mice, and their activities are dependent on ER? variants, promoter-, cell-context and selective use of different Sp proteins, suggesting...

  18. Opiate activity in the rat prefrontal cortex: modulation of ventral tegmental area dopaminergic influence on cortical efferent neurons

    E-Print Network [OSTI]

    St. Mary, John Steven

    1986-01-01T23:59:59.000Z

    OPIATE ACTIVITY IN THE RAT PREFRONTAL CORTEX: MODULATION OF VENTRAL TEGMENTAL AREA DOPAMINERGIC INFLUENCE ON CORTICAL EFFERENT NEURONS A Thesis by JOHN STEVEN ST. MARY Submitted to the Graduate College of Texas A&M University in partial... Thesis by JOHN STEVEN ST. MARY Approved as to style and content by: Steven Peterson (Chairman of Committee) Robert Matthews (- '" j'pj") Ger a ((~Fe g (Mem er) George Chion (Member) December 1986 ABSTRACT Opiate Activity in the Rat...

  19. Electron spin resonance study of Er-concentration effect in GaAs;Er,O containing charge carriers

    SciTech Connect (OSTI)

    Elmasry, F. [Graduate School of Science, Kobe University, 1-1 Rokkodai-cho, Nada, Kobe 657-8501 (Japan); Okubo, S. [Molecular Photoscience Research Center, Kobe University, 1-1 Rokkodai-cho, Nada, Kobe 657-8501 (Japan); Ohta, H., E-mail: hoht@kobe-u.ac.jp [Graduate School of Science, Kobe University, 1-1 Rokkodai-cho, Nada, Kobe 657-8501 (Japan); Molecular Photoscience Research Center, Kobe University, 1-1 Rokkodai-cho, Nada, Kobe 657-8501 (Japan); Fujiwara, Y. [Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871 (Japan)

    2014-05-21T23:59:59.000Z

    Er-concentration effect in GaAs;Er,O containing charge carriers (n-type, high resistance, p-type) has been studied by X-band Electron spin resonance (ESR) at low temperature (4.7?K?Er,O without carrier. The local structure around Er-2O centers is not affected by carriers because similar angular dependence of g-values was observed in both cases (with/without carrier). For temperature dependence, linewidth and lineshape analysis suggested the existence of Er dimers with antiferromagnetic exchange interaction of about 7?K. Moreover, drastic decrease of ESR intensity for C signal in p-type sample was observed and it correlates with the decrease of photoluminescence (PL) intensity. Possible model for the Er-2O trap level in GaAs:Er,O is discussed from the ESR and PL experimental results.

  20. Balanced Ero1 activation and inactivation establishes ER redox homeostasis

    E-Print Network [OSTI]

    Kim, Sunghwan

    The endoplasmic reticulum (ER) provides an environment optimized for oxidative protein folding through the action of Ero1p, which generates disulfide bonds, and Pdi1p, which receives disulfide bonds from Ero1p and transfers ...

  1. Coordination of Endoplasmic Reticulum (ER) Signaling During Maize Seed Development

    SciTech Connect (OSTI)

    Boston, Rebecca S.

    2010-11-20T23:59:59.000Z

    Seed storage reserves represent one of the most important sources of renewable fixed carbon and nitrogen found in nature. Seeds are well-adapted for diverting metabolic resources to synthesize storage proteins as well as enzymes and structural proteins needed for their transport and packaging into membrane bound storage protein bodies. Our underlying hypothesis is that the endoplasmic reticulum (ER) stress response provides the critical cellular control of metabolic flux required for optimal accumulation of storage reserves in seeds. This highly conserved response is a cellular mechanism to monitor the protein folding environment of the ER and restore homeostasis in the presence of unfolded or misfolded proteins. In seeds, deposition of storage proteins in protein bodies is a highly specialized process that takes place even in the presence of mutant proteins that no longer fold and package properly. The capacity of the ER to deposit these aberrant proteins in protein bodies during a period that extends several weeks provides an excellent model for deconvoluting the ER stress response of plants. We have focused in this project on the means by which the ER senses and responds to functional perturbations and the underlying intracellular communication that occurs among biosynthetic, trafficking and degradative pathways for proteins during seed development.

  2. ER=EPR, GHZ, and the Consistency of Quantum Measurements

    E-Print Network [OSTI]

    Leonard Susskind

    2014-12-29T23:59:59.000Z

    This paper illustrates various aspects of the ER=EPR conjecture.It begins with a brief heuristic argument, using the Ryu-Takayanagi correspondence, for why entanglement between black holes implies the existence of Einstein-Rosen bridges. The main part of the paper addresses a fundamental question: Is ER=EPR consistent with the standard postulates of quantum mechanics? Naively it seems to lead to an inconsistency between observations made on entangled systems by different observers. The resolution of the paradox lies in the properties of multiple black holes, entangled in the Greenberger-Horne-Zeilinger pattern. The last part of the paper is about entanglement as a resource for quantum communication. ER=EPR provides a way to visualize protocols like quantum teleportation. In some sense teleportation takes place through the wormhole, but as usual, classical communication is necessary to complete the protocol.

  3. Pahute Mesa Well Development and Testing Analyses for Wells ER-20-7, ER-20-8 #2, and ER-EC-11, Revision 1

    SciTech Connect (OSTI)

    Greg Ruskauff

    2011-12-01T23:59:59.000Z

    This report analyzes the following data collected from ER-20-7, ER-20-8 No.2, and ER-EC-11 during WDT operations: (1) Chemical indicators of well development (Section 2.0); (2) Static hydraulic head (Section 3.0); (3) Radiochemistry and geochemistry (Section 4.0); (4) Drawdown observed at locations distal to the pumping well (Section 5.0); and (5) Drilling water production, flow logs, and temperature logs (Section 6.0). The new data are further considered with respect to existing data as to how they enhance or change interpretations of groundwater flow and transport, and an interim small-scale conceptual model is also developed and compared to Phase I concepts. The purpose of well development is to remove drilling fluids and drilling-associated fines from the formation adjacent to a well so samples reflecting ambient groundwater water quality can be collected, and to restore hydraulic properties near the well bore. Drilling fluids can contaminate environmental samples from the well, resulting in nonrepresentative measurements. Both drilling fluids and preexisting fines in the formation adjacent to the well can impede the flow of water from the formation to the well, creating artifacts in hydraulic response data measured in the well.

  4. Blocking long term consolidation of extinction in rats with puromycin

    E-Print Network [OSTI]

    Broussard, William Joseph

    1972-01-01T23:59:59.000Z

    OF SCIBNC August 1972 )major Subject: Psychology BLOCKING LONG TERM CONSOLIDATION OF EXTINCTION IN RATS WI ' H PUROMYCIN A Thesis WILLIAM JOSEPH BROUSSARD Approved as to style and content by~ c'F, ~ g, Chairman of Co j. ttee H o e ar men Mem er..., snd Joseph . "lagyvary, this manuscript would have been considerably longer in taking shape. The author e. ,pecially wishes to call attention to his wife. If tolerance, patience, and encourageme. , t can be considered part of a higher education...

  5. Video Entity Resolution: Applying ER Techniques for Smart Video Surveillance

    E-Print Network [OSTI]

    Kalashnikov, Dmitri V.

    buildings, smart grid, and so on. In this paper, we focus on smart surveillance systems wherein video improvements on how the building is used. One of the key challenges in building smart surveillance systemsVideo Entity Resolution: Applying ER Techniques for Smart Video Surveillance Liyan Zhang Ronen

  6. Economic Impact Report BInghamton UnIvERsIty

    E-Print Network [OSTI]

    Suzuki, Masatsugu

    Economic Impact Report 2007 #12;BInghamton UnIvERsIty 8:1 return on investment The term "return will be returned to the state economy and $6 to the local economy -- delivering an economic impact of $8.65 billion as an engine of economic growth that improves the financial health of our region and state. EconomIc Impact

  7. ALGEBRA LINEAL I 1er Curso de CC. Fisicas.

    E-Print Network [OSTI]

    Guijarro, Luis

    ´ALGEBRA LINEAL I 1er Curso de CC. F´isicas. Examen Final. 4 de Febrero de 2008. Apellidos: Nombre subespacio complementario de S1 S2. 4. Hallar la matriz en la base can´onica de una aplicaci´on lineal f : R

  8. Dette er en overskrift > Grn forskning -Status og perspektiver 1

    E-Print Network [OSTI]

    #12;> Grøn forskning - Status og perspektiver2 indhold forord 3 1. indledning 4 2. Danmark som Det er regeringens ambition at gøre Danmark til en grøn vækstnation. Vi har et godt udgangspunkt, men vision, at Danmark udvikler sig til et internationalt center for grøn forskning og innovation. Denne

  9. ccsd00001676, Epitaxy and growth of titanium bu er layers

    E-Print Network [OSTI]

    ccsd­00001676, version 1 ­ 16 Jun 2004 Epitaxy and growth of titanium bu#11;er layers on Al 2 O 3 de Lourmel, 75015 Paris, France Abstract The structure and growth of thin #12;lms of titanium on #11 [2110] and Ti[1010] k Al 2 O 3 [1100] epitaxy of the #11; phase of titanium reported before for thick

  10. Effects of material growth technique and Mg doping on Er{sup 3+} photoluminescence in Er-implanted GaN

    SciTech Connect (OSTI)

    Kim, S.; Henry, R. L.; Wickenden, A. E.; Koleske, D. D.; Rhee, S. J.; White, J. O.; Myoung, J. M.; Kim, K.; Li, X.; Coleman, J. J. (and others)

    2001-07-01T23:59:59.000Z

    Photoluminescence (PL) and photoluminescence excitation (PLE) spectroscopies have been carried out at 6 K on the {similar_to}1540 nm {sup 4}I{sub 13/2}{endash}{sup 4}I{sub 15/2} emissions of Er{sup 3+} in Er-implanted and annealed GaN. These studies revealed the existence of multiple Er{sup 3+} centers and associated PL spectra in Er-implanted GaN films grown by metalorganic chemical vapor deposition, hydride vapor phase epitaxy, and molecular beam epitaxy. The results demonstrate that the multiple Er{sup 3+}PL centers and below-gap defect-related absorption bands by which they are selectively excited are universal features of Er-implanted GaN grown by different techniques. It is suggested that implantation-induced defects common to all the GaN samples are responsible for the Er site distortions that give rise to the distinctive, selectively excited Er{sup 3+}PL spectra. The investigations of selectively excited Er{sup 3+}PL and PLE spectra have also been extended to Er-implanted samples of Mg-doped GaN grown by various techniques. In each of these samples, the so-called violet-pumped Er{sup 3+}PL band and its associated broad violet PLE band are significantly enhanced relative to the PL and PLE of the other selectively excited Er{sup 3+}PL centers. More importantly, the violet-pumped Er{sup 3+}PL spectrum dominates the above-gap excited Er{sup 3+}PL spectrum of Er-implanted Mg-doped GaN, whereas it was unobservable under above-gap excitation in Er-implanted undoped GaN. These results confirm the hypothesis that appropriate codopants can increase the efficiency of trap-mediated above-gap excitation of Er{sup 3+} emission in Er-implanted GaN. {copyright} 2001 American Institute of Physics.

  11. Comparative activation of estrogen receptor alpha (er alpha) by endocrine disruptors 

    E-Print Network [OSTI]

    Wu, Fei

    2009-05-15T23:59:59.000Z

    Estrogen receptor ? (ER?) is a ligand activated transcription factor. Many widely used synthetic compounds and natural chemicals can activate ER?. The compounds investigated in this study include 17?-estradiol (E2), diethylstilbestrol (DES...

  12. Structure-Based Virtual Screening for Plant-Based ER -Selective Ligands as

    E-Print Network [OSTI]

    Brinton, Roberta Diaz

    * Department of Molecular Pharmacology & Toxicology and the Program in Neuroscience, School of Pharmacy. Two nuclear receptors for estrogen (ERs), ERR and ER , have been identified. In the central nervous

  13. PROC. NETH. ENTOMOL. SOC. MEET. -VOLUME 19 -2008 31 Denis Michez

    E-Print Network [OSTI]

    Rasmont, Pierre

    of different wild bees. Bees constitute a monophyletic group including 16,000 species in seven families a monophyletic group including more than 16,000 described species and seven families currently acknowledged. In this presentation, we propose an overview of one key group in the bee phylogeny: the Melittidae s.l. We show

  14. Technical Report No. 480 CE: The Classi er Estimator Framework for Data mining

    E-Print Network [OSTI]

    Dalkilic, Mehmet

    Technical Report No. 480 CE: The Classi er Estimator Framework for Data mining Mehmet M. Dalkilic a coherent framework for data mining in the relational model. Observing that data mining depends on two. The classi er indicates the target of the data mining investigation. The classi er may be di cult to express

  15. 10 FUGLE O G N ATUR 0408 f alle vore rovfugle er Hedehgen

    E-Print Network [OSTI]

    Thorup, Kasper

    Danmark, at et større antal fugle har fået vingemærker, men også i bl.a. Tyskland, Holland og Frankrig, og Afrika. Hedehøgen er blevet en sjælden fugl i Danmark, og den er gået tilbage i store dele af dens yngleområde, ikke mindst i Danmark. Vi er stort set på bar bund, når vi taler om, hvorvidt Hedehøgens

  16. ER Membrane Protein Complex Required for Nuclear Fusion Davis T.W. Ng and Peter Walter

    E-Print Network [OSTI]

    Walter, Peter

    ER Membrane Protein Complex Required for Nuclear Fusion Davis T.W. Ng and Peter Walter Department is localized to the luminal (i.e., noncytoplasmic) face of the ER mem- brane, yet nuclear fusion must initiate of Sec63p, Sec71p, and Sec72p plays a central role in mediating nuclear mem- brane fusion and requires ER

  17. In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases

    E-Print Network [OSTI]

    Hebert, Daniel N.

    In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases 1377 C. Protein folding 1378 II. Protein Translocation, Folding, and Quality Control in the Endoplasmic Reticulum 1379 A. Protein targeting to the ER 1379 B. Chaperone-assisted protein folding in the ER 1379 C

  18. RATS VERSUS PEOPLE Rats equal twice

    E-Print Network [OSTI]

    , ----= -, - paper car ton s, and wooden containers are easily damaged. #12;By Starting Fires Rats start fires by damaging the insu- lation of electric wiring. A survey of 39 cities showed that 530 fires were started

  19. ALGEBRA LINEAL I 1er Curso de CC. Fisicas.

    E-Print Network [OSTI]

    Guijarro, Luis

    ´ALGEBRA LINEAL I 1er Curso de CC. F´isicas. Examen Extraordinario. 14 de Septiembre de 2006 un vector u perpendicular a L. b) Hallar la matriz de la aplicaci´on lineal f : R3 R3 consistente en la simetr´ia ortogonal respecto al plano de ecuaci´on 2x+y = 0. (Se trata de la aplicaci´on lineal

  20. ALGEBRA LINEAL I 1er Curso de CC. Fisicas.

    E-Print Network [OSTI]

    Guijarro, Luis

    ´ALGEBRA LINEAL I 1er Curso de CC. F´isicas. Examen Final. 9 de Febrero de 2006. Apellidos: Nombrex2 +10 = 0. 2. Dado el sistema de ecuaciones lineales: x -y +2z = 2 x +y -z = 1 2x +az = c 3x +y +bz la base can´onica de R2 de una aplicaci´on lineal de R2 en R2 , tal que f(1, 1) = (0, 1) f(-1, 1

  1. DRH/BPE/BDCS 1er PELICHET Marie

    E-Print Network [OSTI]

    Mesbah, Mounir

    12ème GAYTE Marie 13ème REY Marie-Bénédicte 14ème CONILLEAU Claire 15ème ZOUAOUI Karen 1/12 #12 FAKERI TABRIZI Ali 22e ROMERO RAMIREZ Miguel 23e CREUS TOMAS Jordi 24e DUBOIS Swan 25e MOVAHEDI Zeinab 26 8ème PIERRE Juliette 9ème FRAS François 10ème BOUDET Sophie 11ème HAMIE Ali 1er MEYER Robert 2ème

  2. Final Report DE-FG02-07ER64416

    SciTech Connect (OSTI)

    Seymour, Joseph D.

    2014-02-01T23:59:59.000Z

    The document provides the Final Report for DE-FG02-07ER64416 on the use of magnetic resonance (MR) methods to quantify transport in porous media impacted by biological and chemical processes. Products resulting from the research in the form of peer reviewed publications and conference presentations are presented. The research correlated numerical simulations and MR measurements to test simulation methodology. Biofilm and uranium detection by MR was demonstrated.

  3. Tunable, diode side-pumped Er: YAG laser

    DOE Patents [OSTI]

    Hamilton, Charles E. (Bellevue, WA); Furu, Laurence H. (Modesto, CA)

    1997-01-01T23:59:59.000Z

    A discrete-element Er:YAG laser, side pumped by a 220 Watt peak-power InGaAs diode array, generates >500 mWatts at 2.94 .mu.m, and is tunable over a 6 nm range near about 2.936 .mu.m. The oscillator is a plano-concave resonator consisting of a concave high reflector, a flat output coupler, a Er:YAG crystal and a YAG intracavity etalon, which serves as the tuning element. The cavity length is variable from 3 cm to 4 cm. The oscillator uses total internal reflection in the Er:YAG crystal to allow efficient coupling of the diode emission into the resonating modes of the oscillator. With the tuning element removed, the oscillator produces up to 1.3 Watts of average power at 2.94 .mu.m. The duty factor of the laser is 6.5% and the repetition rate is variable up to 1 kHz. This laser is useful for tuning to an atmospheric transmission window at 2.935 .mu.m (air wavelength). The laser is also useful as a spectroscopic tool because it can access several infrared water vapor transitions, as well as transitions in organic compounds. Other uses include medical applications (e.g., for tissue ablation and uses with fiber optic laser scalpels) and as part of industrial effluent monitoring systems.

  4. Tunable, diode side-pumped Er:YAG laser

    DOE Patents [OSTI]

    Hamilton, C.E.; Furu, L.H.

    1997-04-22T23:59:59.000Z

    A discrete-element Er:YAG laser, side pumped by a 220 Watt peak-power InGaAs diode array, generates >500 mWatts at 2.94 {micro}m, and is tunable over a 6 nm range near about 2.936 {micro}m. The oscillator is a plano-concave resonator consisting of a concave high reflector, a flat output coupler, a Er:YAG crystal and a YAG intracavity etalon, which serves as the tuning element. The cavity length is variable from 3 cm to 4 cm. The oscillator uses total internal reflection in the Er:YAG crystal to allow efficient coupling of the diode emission into the resonating modes of the oscillator. With the tuning element removed, the oscillator produces up to 1.3 Watts of average power at 2.94 {micro}m. The duty factor of the laser is 6.5% and the repetition rate is variable up to 1 kHz. This laser is useful for tuning to an atmospheric transmission window at 2.935 {micro}m (air wavelength). The laser is also useful as a spectroscopic tool because it can access several infrared water vapor transitions, as well as transitions in organic compounds. Other uses include medical applications (e.g., for tissue ablation and uses with fiber optic laser scalpels) and as part of industrial effluent monitoring systems. 4 figs.

  5. COMPLETION REPORT FOR WELL CLUSTER ER-5-3

    SciTech Connect (OSTI)

    BECHTEL NEVADA

    2005-12-01T23:59:59.000Z

    Well Cluster ER-5-3 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This cluster of 3 wells was drilled in 2000 and 2001 as part of a hydrogeologic investigation program in Frenchman Flat. The first borehole in the cluster, Well ER-5-3, was drilled in February and March 2000. A 47.0-centimeter surface hole was drilled and cased off to the depth of 374.8 meters. The hole diameter was decreased to 31.1 centimeters for drilling to a total depth of 794.3 meters within welded ash-flow tuff. A piezometer string with 1 slotted interval was installed in the annulus of the surface casing, open to the saturated alluvium. A completion string with 2 slotted intervals was installed in the main hole, open to saturated alluvium and to the welded tuff aquifer. A second piezometer string with 1 slotted interval open to the welded-tuff aquifer was installed outside the completion string. Well ER-5-3 No.2 was drilled about 30 meters west of the first borehole in March 2000, and was recompleted in March 2001. A 66.0-centimeter hole was drilled and cased off to the depth of 613.8 meters. The hole diameter was decreased to 44.5 centimeters and the borehole was drilled and cased off to the depth of 849.0 meters. The hole diameter was decreased once more to 31.1 centimeters for drilling to a total depth of 1,732.2 meters in dolomite. A completion string open to the dolomite (lower carbonate aquifer) was installed. Well ER-5-3 No.3 was drilled approximately 30 meters north of the first 2 boreholes in February 2001. A 66.0-centimeter hole was drilled and cased off to the depth of 36.6 meters, then the main 25.1-centimeter-diameter hole was drilled to a total depth of 548.6 meters in alluvium. A slotted stainless-steel tubing string was installed in the saturated alluvium. A preliminary composite, static water level was measured at the depth of 282.6 meters, prior to development and hydrologic testing. Detailed lithologic descriptions and stratigraphic assignments are included in the report. These are based on composite drill cuttings collected every 3 meters, and 120 sidewall samples taken at various depths below 91 meters in Wells ER-5-3 and ER-5-3 No.2, supplemented by geophysical log data. The wells penetrated Quaternary/Tertiary alluvium to the depth of 622.4 meters, and an 8.5-meter-thick basalt flow was encountered within the alluvium. Tertiary tuff was penetrated to the depth of approximately 1,425.9 meters, where the top of the lower carbonate aquifer was tagged in Well ER-5-3 No.2.

  6. Controlling Rats and Mice

    E-Print Network [OSTI]

    Texas Wildlife Services

    2007-03-13T23:59:59.000Z

    at least 18 inches off the ground. 18? 18? TCE?Wildlife Services P.O. Box 100410 ? San Antonio, Texas 78201-1710 Rat-proofing Whenever it can be accomplished at a rea- sonable cost, rat-proofing is recommended as the most permanent means of control...

  7. Lifetimes of negative parity states in {sup 168}Er

    SciTech Connect (OSTI)

    Genilloud, L. [Institut de Physique, Universite de Fribourg, Perolles, CH-1700 Fribourg, (Switzerland)] [Institut de Physique, Universite de Fribourg, Perolles, CH-1700 Fribourg, (Switzerland); Jolie, J. [Institut de Physique, Universite de Fribourg, Perolles, CH-1700 Fribourg, (Switzerland)] [Institut de Physique, Universite de Fribourg, Perolles, CH-1700 Fribourg, (Switzerland); Boerner, H. G. [Institut Laue-Langevin, F-38042 Grenoble Cedex 9, (France)] [Institut Laue-Langevin, F-38042 Grenoble Cedex 9, (France); Lehmann, H. [Institut Laue-Langevin, F-38042 Grenoble Cedex 9, (France)] [Institut Laue-Langevin, F-38042 Grenoble Cedex 9, (France); Becvar, F. [Faculty of Mathematics and Physics, Charles University, CZ-180 00 Prague 8, (Czech Republic)] [Faculty of Mathematics and Physics, Charles University, CZ-180 00 Prague 8, (Czech Republic); Krticka, M. [Faculty of Mathematics and Physics, Charles University, CZ-180 00 Prague 8, (Czech Republic)] [Faculty of Mathematics and Physics, Charles University, CZ-180 00 Prague 8, (Czech Republic); Zamfir, N. V. [WNSL, Yale University, New Haven, Connecticut 06520 (United States) [WNSL, Yale University, New Haven, Connecticut 06520 (United States); Clark University, Worcester, Massachusetts 01610 (United States); Casten, R. F. [WNSL, Yale University, New Haven, Connecticut 06520 (United States)] [WNSL, Yale University, New Haven, Connecticut 06520 (United States)

    2000-09-01T23:59:59.000Z

    Using the GRID method the lifetimes of 12 states belonging to four negative parity bands in {sup 168}Er were measured at the high flux reactor of the Institut Laue-Langevin (ILL). For K{sup {pi}}=0{sub 1}{sup -} and K{sup {pi}}=2{sub 1}{sup -} bands the absolute E1 transitions are in agreement with those obtained within the framework of the sdf IBA-1 model and their octupole vibrational character is confirmed. (c) 2000 The American Physical Society.

  8. Completion report for well ER-3-2

    SciTech Connect (OSTI)

    NONE

    1995-12-01T23:59:59.000Z

    Well ER-3-2 was drilled for the U.S. Department of Energy, Nevada Operations Office (DOE/NV), in support of the Nevada Environmental Restoration Project (NV ERP) at the Nevada Test Site. IT Corporation (IT) was the principal environmental contractor for the project. The roles and responsibilities of IT and other contractors involved in the project are described in the Raytheon Services Nevada (RSN) Drilling Program and the Underground Test Area Operable Unit Project Management Plan. The well will become part of the Underground Test Area (UGTA) monitoring well network.

  9. Photoluminescence and positron annihilation spectroscopy investigation of (Ge, Er) codoped Si oxides deposited by magnetron sputtering

    SciTech Connect (OSTI)

    Heng, C. L.; Chelomentsev, E.; Peng, Z. L.; Mascher, P. [Department of Engineering Physics and Centre for Emerging Device Technologies, McMaster University, Hamilton, Ontario L8S 4K1 (Canada); Simpson, P. J. [Department of Physics and Astronomy, University of Western Ontario, London, Ontario N6A 3K7 (Canada)

    2009-01-01T23:59:59.000Z

    We have investigated the nature of violet-blue emission from (Ge, Er) codoped Si oxides (Ge+Er+SiO{sub 2}) using photoluminescence (PL) and positron annihilation spectroscopy (PAS) measurements. The PL spectra and PAS analysis for a control Ge-doped SiO{sub 2} (Ge+SiO{sub 2}) indicate that Ge-associated neutral oxygen vacancies (Ge-NOV) are likely responsible for the major emission in the violet-blue band. For Ge+Er+SiO{sub 2}, both Ge-NOV and GeO color centers are believed to be responsible for the emission band. The addition of Er has a significant influence on the emission, which is discussed in terms of Er-concentration-related structural change in the Ge+Er+SiO{sub 2}.

  10. Control of cell division by nutrients, and ER stress signaling in Saccharomyces cerevisiae

    E-Print Network [OSTI]

    Guo, Jinbai

    2007-09-17T23:59:59.000Z

    /glucose deprivation, elevated protein synthesis, expression of misfolded proteins and blocked secretory pathway (Lee, 1992). Mutations impairing the client protein folding or chemicals that disturb the protein folding can cause ER stress (Gething and Sambrook, 1992... cells have evolved specific signaling pathways and effector mechanisms to deal with ER stress. By the late 1980s, it had been known that there is a 13 specific link between manipulations that perturb protein folding in the ER and the induction...

  11. Specific features of the nonradiative relaxation of Er{sup 3+} ions in epitaxial Si structures

    SciTech Connect (OSTI)

    Kudryavtsev, K. E., E-mail: konstantin@ipmras.ru; Kryzhkov, D. I.; Antonov, A. V.; Shengurov, D. V.; Shmagin, V. B.; Krasilnik, Z. F. [Russian Academy of Sciences, Institute for Physics of Microstructures (Russian Federation)

    2014-12-15T23:59:59.000Z

    The specific features of the nonradiative relaxation of Er{sup 3+} ions in Si:Er layers grown by sublimation molecular-beam epitaxy (SMBE) are studied. In Si:Er/Si diode structures containing precipitation-type emitting centers, a resonance photoresponse at the wavelength ? ? 1.5 ?m is observed, which is indicative of the nonradiative relaxation of Er3+ ions via the energy back-transfer mechanism. Saturation of the erbium-related photocurrent is for the first time observed at high temperatures. This allows estimation of the concentration of Er centers that undergo relaxation via the above-mentioned back-transfer mechanism (N{sub 0} ? 5 × 10{sup 16} cm{sup ?3}). In terms of order of magnitude, the estimated concentration N{sub 0} corresponds to the concentration of optically active Er ions upon excitation of the Si:Er layers by means of the recombination mechanism. The features of the nonradiative relaxation of Er{sup 3+} ions in Si:Er/Si structures with different types of emitting centers are analyzed.

  12. Completion Report for Well ER-2-1

    SciTech Connect (OSTI)

    Bechtel Nevada

    2004-10-01T23:59:59.000Z

    Well ER-2-1 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (formerly Nevada Operations Office), in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in February and March of 2003, as part of a hydrogeologic investigation program for the Yucca Flat/Climax Mine Corrective Action Unit in the northeastern portion of the Nevada Test Site. Well ER-2-1 was drilled as part of the Yucca Flat Corrective Action Unit Phase I drilling initiative. The well is located in north central Yucca Flat within Area 2 of the Nevada Test Site, and provided information regarding the radiological and physical environment near underground nuclear tests conducted in a saturated volcanic aquifer setting. Detailed lithologic descriptions with stratigraphic assignments are included in this report. These are based on composite drill cuttings collected every 3 meters and 83 sidewall samples taken at various depths between 113.7 and 754.4 meters, supplemented by geophysical log data. Detailed petrographic, chemical, and mineralogical studies of rock samples were conducted on 27 samples of drill cuttings. The well was collared in tuffaceous alluvium, and penetrated Tertiary-age tuffs of the Timber Mountain and Paintbrush Groups, Calico Hills and Wahmonie Formations, Crater Flat Group, Grouse Canyon Formation, before reaching total depth in the Tunnel Bed Formation.

  13. Completion Report for Well ER-8-1

    SciTech Connect (OSTI)

    Bechtel Nevada

    2004-11-01T23:59:59.000Z

    Well ER-8-1 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in October and November of 2002 as part of a Hydrogeologic investigation program for the Yucca Flat/Climax Mine Corrective Action Unit in the northeastern portion of the Nevada Test Site. Well ER-8-1 is located at the north end of Yucca Flat approximately 580 meters south-southeast of the surface exposure of the Climax granitic intrusive. Detailed lithologic descriptions with stratigraphic assignments are included in this report. These are based on composite drill cuttings samples collected every 3 meters, and 21 sidewall samples taken at various depths between 351.1 and 573.0 meters, supplemented by incomplete geophysical log data. Detailed petrographic, geochemical, and mineralogical studies of rock samples were conducted on 22 samples of drill cuttings. Drilling began in tuffaceous alluvium, and the borehole penetrated Tertiary age bedded tuffs of the Volcanics of Oak Spring Butte and carbonate sediments of Paleozoic age, which were encountered at a depth of 334 meters. The borehole unexpectedly penetrated granite at the depth of 538.9 meters in which drilling was stopped. Contact metamorphic rocks and intrusive dikes associated with the Cretaceous-age granitic intrusive and at least one significant fault zone were encountered.

  14. 2001 4232 -0 Aerospace EngineeringBokadia and Valasek SEV ER E W EATH ER AV O ID AN C E

    E-Print Network [OSTI]

    Valasek, John

    2001 ­ 4232 -0 Aerospace EngineeringBokadia and Valasek SEV ER E W EATH ER AV O ID AN C E U SIN G IN FO R M ED H EU R ISTIC SEAR C H AIAA-2001-4232 Sangeeta Bokadia and Dr. John Valasek Aerospace Engineering AIAA GN&C Conference, Montreal, Canada 7 August 2001 #12;2001 ­ 4232 -1 Aerospace Engineering

  15. Pieter Kik OASIS Workshop, Italy 2002 Towards an Er doped Si nanocrystal sensitized WG laser -

    E-Print Network [OSTI]

    Kik, Pieter

    Pieter Kik ­ OASIS Workshop, Italy 2002 Towards an Er doped Si nanocrystal sensitized WG laser Physics Amsterdam, The Netherlands #12;Pieter Kik ­ OASIS Workshop, Italy 2002 Er fiber amplifiersSiO2 broad energy bands allowed abs(458nm) 2×10-16 cm2 use cheap pump diode? #12;Pieter Kik ­ OASIS

  16. Nearly quantum-noise-limited timing jitter from miniature Er:Yb:glass lasers

    E-Print Network [OSTI]

    Keller, Ursula

    Nearly quantum-noise-limited timing jitter from miniature Er:Yb:glass lasers A. Schlatter, B. Rudin Received January 4, 2005 We report on nearly quantum-limited timing-jitter performance of two passively mode-locked Er:Yb:glass lasers with a repetition rate of 10 GHz. The relative timing jitter of both

  17. Exploiting Hysteresis in a CMOS Bu er Radu M. Secareanu, Victor Adler, and Eby G. Friedman

    E-Print Network [OSTI]

    Friedman, Eby G.

    tapered bu ers 2 6 have been proposed. Approaches for driving highly resis- tive RC lines for optimal placement, sizing, and power dissipation. A CMOS in- verter driving a distributed RC line is shown@ece.rochester.edu, adler@ece.rochester.edu, friedman@ece.rochester.edu Abstract| A high drive CMOS bu er circuit character

  18. PO*WW*ER mobile treatment unit process hazards analysis

    SciTech Connect (OSTI)

    Richardson, R.B.

    1996-06-01T23:59:59.000Z

    The objective of this report is to demonstrate that a thorough assessment of the risks associated with the operation of the Rust Geotech patented PO*WW*ER mobile treatment unit (MTU) has been performed and documented. The MTU was developed to treat aqueous mixed wastes at the US Department of Energy (DOE) Albuquerque Operations Office sites. The MTU uses evaporation to separate organics and water from radionuclides and solids, and catalytic oxidation to convert the hazardous into byproducts. This process hazards analysis evaluated a number of accident scenarios not directly related to the operation of the MTU, such as natural phenomena damage and mishandling of chemical containers. Worst case accident scenarios were further evaluated to determine the risk potential to the MTU and to workers, the public, and the environment. The overall risk to any group from operation of the MTU was determined to be very low; the MTU is classified as a Radiological Facility with low hazards.

  19. Completion Report for Well ER-EC-1

    SciTech Connect (OSTI)

    Townsend, M.J.

    2000-12-01T23:59:59.000Z

    Well ER-EC-1 was drilled for the U.S. Department of Energy, Nevada Operations Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the spring of 1999 as part of the U.S. Department of Energy's hydrogeologic investigation well program in the Western Pahute Mesa - Oasis Valley region just west of the Test Site. A 44.5-centimeter surface hole was drilled and cased off to the depth 675.1 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 1,524.0 meters. A preliminary composite, static, water level was measured at the depth of approximately 566.3 meters prior to installation of the completion string. One completion string with three isolated, slotted intervals was installed in the well. Detailed lithologic descriptions with preliminary stratigraphic assignments are included in the report. These are based on composite drill cuttings collected every 3 meters and 31 sidewall samples taken at various depths below 680 meters, supplemented by geophysical log data. Detailed chemical and mineralogical studies of rock samples are in progress. The well penetrated Tertiary-age lava and tuff of the Timber Mountain Group, the Paintbrush Group, the Calico Hills Formation, the Crater Flat Group, and the Volcanics of Quartz Mountain. The preliminary geologic interpretation of data from Well ER-EC-1 indicates the presence of a structural trough or bench filled with a thick section of post-Rainier Mesa lava. These data also suggest that this site is located on a buried structural ridge that may separate the Silent Canyon and Timber Mountain caldera complexes.

  20. Carrier transfer from InAs quantum dots to ErAs metal nanoparticles

    SciTech Connect (OSTI)

    Haughn, C. R.; Chen, E. Y.; Zide, J. M. O.; Doty, M. F., E-mail: doty@udel.edu [Department of Materials Science and Engineering, University of Delaware, Newark, Delaware 19716 (United States); Steenbergen, E. H.; Bissell, L. J.; Eyink, K. G. [AFRL/RXAN, Wright Patterson AFB, Ohio 45433 (United States)

    2014-09-08T23:59:59.000Z

    Erbium arsenide (ErAs) is a semi-metallic material that self-assembles into nanoparticles when grown in GaAs via molecular beam epitaxy. We use steady-state and time-resolved photoluminescence to examine the mechanism of carrier transfer between indium arsenide (InAs) quantum dots and ErAs nanoparticles in a GaAs host. We probe the electronic structure of the ErAs metal nanoparticles (MNPs) and the optoelectronic properties of the nanocomposite and show that the carrier transfer rates are independent of pump intensity. This result suggests that the ErAs MNPs have a continuous density of states and effectively act as traps. The absence of a temperature dependence tells us that carrier transfer from the InAs quantum dots to ErAs MNPs is not phonon assisted. We show that the measured photoluminescence decay rates are consistent with a carrier tunneling model.

  1. Endoplasmic reticulum stress is involved in arsenite-induced oxidative injury in rat brain

    SciTech Connect (OSTI)

    Lin, Anya M.Y. [Department of Physiology, National Yang-Ming University, Taipei, Taiwan (China); Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan (China); Chao, P.L.; Fang, S.F.; Chi, C.W. [Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan (China); Yang, C.H. [Department of Oncology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan (China)], E-mail: chihyang@ntu.edu.tw

    2007-10-15T23:59:59.000Z

    The mechanism underlying sodium arsenite (arsenite)-induced neurotoxicity was investigated in rat brain. Arsenite was locally infused in the substantia nigra (SN) of anesthetized rat. Seven days after infusion, lipid peroxidation in the infused SN was elevated and dopamine level in the ipsilateral striatum was reduced in a concentration-dependent manner (0.3-5 nmol). Furthermore, local infusion of arsenite (5 nmol) decreased GSH content and increased expression of heat shock protein 70 and heme oxygenase-1 in the infused SN. Aggregation of {alpha}-synuclein, a putative pathological protein involved in several CNS neurodegenerative diseases, was elevated in the arsenite-infused SN. From the breakdown pattern of {alpha}-spectrin, both necrosis and apoptosis were involved in the arsenite-induced neurotoxicity. Pyknotic nuclei, cellular shrinkage and cytoplasmic disintegration, indicating necrosis, and TUNEL-positive cells and DNA ladder, indicating apoptosis was observed in the arsenite-infused SN. Arsenite-induced apoptosis was mediated via two different organelle pathways, mitochondria and endoplasmic reticulum (ER). For mitochondrial activation, cytosolic cytochrome c and caspase-3 levels were elevated in the arsenite-infused SN. In ER pathway, arsenite increased activating transcription factor-4, X-box binding protein 1, C/EBP homologues protein (CHOP) and cytosolic immunoglobulin binding protein levels. Moreover, arsenite reduced procaspase 12 levels, an ER-specific enzyme in the infused SN. Taken together, our study suggests that arsenite is capable of inducing oxidative injury in CNS. In addition to mitochondria, ER stress was involved in the arsenite-induced apoptosis. Arsenite-induced neurotoxicity clinically implies a pathophysiological role of arsenite in CNS neurodegeneration.

  2. Super Rat Poison Man

    E-Print Network [OSTI]

    Hacker, Randi; Tsutsui, William

    2007-04-04T23:59:59.000Z

    Bob Square Tie. But Zheng Xiaoyu, the deposed head of China's State Food and Drug Administration begs to be excused. A rat poison manufacturer here in China applied for permission to name some of its products after him, partly because he's corrupt...

  3. Completion Report for Wells ER-20-8 and ER-20-8#2 Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    SciTech Connect (OSTI)

    NSTec Environmental Management

    2011-02-28T23:59:59.000Z

    Wells ER-20-8 and ER-20-8#2 were drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada National Security Site (formerly Nevada Test Site), Nye County, Nevada. The holes were drilled in July and August 2009, as part of the Pahute Mesa Phase II drilling program. The primary purpose of these wells was to provide detailed hydrogeologic information in the Tertiary volcanic section that will help address uncertainties within the Pahute Mesa–Oasis Valley hydrostratigraphic framework model. They may also be used as long-term monitoring wells.

  4. FUNDRAISING AND GIFT ACCEPTANCE University Policy No: ER4105 Classification: External Relations

    E-Print Network [OSTI]

    Victoria, University of

    1 FUNDRAISING AND GIFT ACCEPTANCE University Policy No: ER4105 Classification: External Relations.01 For Gifts-in-kind to the Library or to the University of Victoria Art Collection, authority may be delegated

  5. Ingefr p tropiske er Af projektleder, seniorforsker, ph.d. Axel Dalberg Poulsen,

    E-Print Network [OSTI]

    og et stort øko- nomisk potentiale. I tropiske lande bruges mange flere arter end i Danmark. De Danmark. #12;242 Endvidere indsamledes frø, som senere er spiret i vækst- huse i Den Kongelige Botaniske

  6. Ris har udgivet en rapport om moderne bioenergi. Den slr fast, at biomasse er en

    E-Print Network [OSTI]

    ressource som vind, og at Danmark vil kunne spille en væsentlig rolle i udviklingen af den teknologi, der, både til det danske samfund og den øvrige verden. Samtidig er Danmark verdens største

  7. Influence of Bi on the Er luminescence in yttrium-erbium disilicate thin films

    SciTech Connect (OSTI)

    Scarangella, Adriana [MATIS-IMM CNR, Via S. Sofia 64, 95123 Catania (Italy); Dipartimento di Fisica e Astronomia, Università di Catania, Via S. Sofia 64, 95123 Catania (Italy); Miritello, Maria, E-mail: maria.miritello@ct.infn.it [MATIS-IMM CNR, Via S. Sofia 64, 95123 Catania (Italy); Priolo, Francesco [MATIS-IMM CNR, Via S. Sofia 64, 95123 Catania (Italy); Dipartimento di Fisica e Astronomia, Università di Catania, Via S. Sofia 64, 95123 Catania (Italy); Scuola Superiore di Catania, Università di Catania, Via Valdisavoia 9, 95123 Catania (Italy)

    2014-09-28T23:59:59.000Z

    The influence of bismuth on erbium optical properties at 1.54??m has been investigated in yttrium-erbium disilicate thin films synthesized by magnetron co-sputtering and implanted with two Bi different doses. The Bi depth distribution and the evolution of its oxidation states after annealing treatments at 1000?°C in two atmospheres, O{sub 2} and N{sub 2}, have been investigated. It was found that only in O{sub 2} the Bi{sup 3+} valence state is prevalent, thanks to the enhanced Bi mobility in the oxidizing ambient, as demonstrated by Rutherford backscattering spectrometry. At lower Bi content, although the formation of Bi{sup 0} metallic nanoparticles that are deleterious non radiative channels for Er luminescence, efficient energy transfer from Bi to Er has been obtained only in O{sub 2}. It is due to the excitation of ultraviolet broad Bi{sup 3+} absorption band and the energy transfer to Er ions. We have evaluated that in this case, Er effective excitation cross section increased by a factor of 5 in respect with the one for direct Er absorption at 488?nm. At higher Bi dose, this mechanism is absent, but an increased Er optical efficiency at 1.54??m has been observed under resonant excitation. It is due to the contribution of a fraction of Er ions having an increased lifetime. This phenomenon is associated with the formation of Bi agglomerates, induced at higher Bi doses, which well isolate Er from non-radiative quenching centers. The increased decay time assures higher optical efficiency at 1.54??m.

  8. At skrive speciale eller ph.d.-afhandling p Ris er en mulighed

    E-Print Network [OSTI]

    forskningsmiljø- et. Det er en god ballast at have med i det senere karriereforløb". Når seniorforsker Jimmy Bak for Optik og Fluid Dynamik udbyder Jimmy Bak et forskningsprojekt som del af et ph.d.-studie. Projektet, der ugen. Side 11 >> E-mail: jimmy.bak@risoe.dk "Som vejleder vil jeg påstå, at udfor- dringen ikke kun er

  9. Completion Report for Well ER-EC-2A

    SciTech Connect (OSTI)

    M. J. Townsend

    2002-03-01T23:59:59.000Z

    Well ER-EC-2A was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Operations Office, in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in January and February of 2000 as part of a hydrogeologic investigation program in the Pahute Mesa - Oasis Valley region just west of the Nevada Test Site. A 44.5-centimeter surface hole was drilled and cased off to a depth of 412.9 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 1,516.1 meters. One completion string with three isolated slotted intervals was installed in the well. A preliminary composite, static water level was measured at the depth of 228.0 meters, approximately two months after installation of the completion string. Detailed lithologic descriptions with preliminary stratigraphic assignments are included in this report. These are based on composite drill cuttings collected every 3 meters, and 81 sidewall samples taken at various depths below 212 meters, supplemented by geophysical log data. Detailed petrographic, chemical, and mineralogical studies of rock samples were conducted on 30 samples. The well was collared in rhyolite lava and penetrated Tertiary-age lava and tuff of the Volcanics of Fortymile Canyon and the Timber Mountain Group. The preliminary geologic interpretation of borehole data indicates that this well was drilled within the margins of the buried Rainier Mesa and Ammonia Tanks calderas, and that caldera collapse in this area was deeper than expected, resulting in a section of Volcanics of Fortymile Canyon (caldera-filling deposit) that is much thicker than expected.

  10. Completion Report for Well ER-EC-4

    SciTech Connect (OSTI)

    M. J. Townsend

    2000-09-01T23:59:59.000Z

    Well ER-EC-4 was drilled for the US Department of Energy, Nevada Operations Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the summer of 1999 as part of the U.S Department of Energy's hydrogeologic investigation well program in the Western Pahute Mesa - Oasis Valley region just west of the Test Site. A 44.5-centimeter surface hole was drilled and cased off to a depth of 263.7 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 1,062.8 meters. One completion string with three isolated slotted intervals was installed in the well. A preliminary composite, static, water level was measured at the depth of 228.3 meters, two months after installation of the completion string. Detailed lithologic descriptions with preliminary stratigraphic assignments are included in the report. These are based on composite drill cuttings collected every 3 meters, and 35 sidewall samples taken at various depths below 286.5 meters, supplemented by geophysical log data. Detailed chemical and mineralogical studies of rock samples are in progress. The well was collared in basalt and penetrated Tertiary-age lava and tuff of the Thirsty Canyon Group, the Volcanics of Fortymile Canyon, and the Timber Mountain Group. The preliminary geologic interpretation of data from this well helps pinpoint the location of the western margin of the Timber Mountain caldera complex in the southern Nevada volcanic field.

  11. Completion Report for Well ER-EC-5

    SciTech Connect (OSTI)

    Bechtel Nevada

    2004-10-01T23:59:59.000Z

    Well ER-EC-5 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the summer of 1999 as part of the U.S. Department of Energy's hydrogeologic investigation program in the Western Pahute Mesa - Oasis Valley region just west of the Nevada Test Site. A 44.5-centimeter surface hole was drilled and cased off to a depth of 342.6 meters below ground surface. The borehole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 762.0 meters. One completion string with three isolated slotted intervals was installed in the well. A preliminary composite, static water level was measured at the depth of 309.9 meters, 40 days after installation of the completion string. Detailed lithologic descriptions with stratigraphic assignments are included in the report. These are based on composite drill cuttings collected every 3 meters, and 18 sidewall samples taken at various depths below 349.6 meters, supplemented by geophysical log data and results from detailed chemical and mineralogical analyses of rock samples. The well penetrated Tertiary-age tuffs of the Thirsty Canyon Group, caldera moat-filling sedimentary deposits, lava of the Beatty Wash Formation, and landslide breccia and tuffs of the Timber Mountain Group. The well reached total depth in welded ashflow tuff of the Ammonia Tanks Tuff after penetrating 440.1 meters of this unit, which is also the main water-producing unit in the well. The geologic interpretation of data from this well constrains the western margin of the Ammonia Tanks caldera to the west of the well location.

  12. Completion report for Well ER-EC-6

    SciTech Connect (OSTI)

    M. J. Townsend

    2000-05-01T23:59:59.000Z

    Well ER-EC-6 was drilled for the U.S. Department of Energy, Nevada Operations Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the spring of 1999 as part of the DOE's hydrogeologic investigation well program in the Western Pahute Mesa - Oasis Valley region just west of the Nevada Test Site. A 66-centimeter surface hole was drilled and cased off to the depth of 485.1 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 1,524.0 meters. A preliminary composite, static, water level was measured at the depth of approximately 434.6 meters prior to installation of the completion string. One completion string with four isolated, slotted intervals was installed in the well. Detailed lithologic descriptions with preliminary stratigraphic assignments are included in the report. These are based on composite drill cuttings collected every 3 meters and 33 sidewall samples taken at various depths below 504.4 meters, supplemented by geophysical log data. Detailed chemical and mineralogical studies of rock samples are in progress. The well penetrated Tertiary-age lava and tuff of the Timber Mountain Group, the Paintbrush Group, the Calico Hills Formation, and the Volcanics of Quartz Mountain. Intense hydrothermal alteration was observed below the depth of 640 m. The preliminary geologic interpretation indicates that this site may be located on a buried structural ridge that separates the Silent Canyon and Timber Mountain caldera complexes.

  13. Completion Report for Well ER-EC-7

    SciTech Connect (OSTI)

    Bechtel Nevada

    2004-10-01T23:59:59.000Z

    Well ER-EC-7 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the summer of 1999 as part of the Department of Energy's hydrogeologic investigation program in the Western Pahute Mesa - Oasis Valley region just west of the Test Site. A 44.5-centimeter surface hole was drilled and cased off to a depth of 265.8 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 422.5 meters. The planned depth of 762 meters was not reached due to borehole stability problems. One completion string with two isolated slotted intervals was installed in the well. A preliminary composite, static, water level was measured at the depth of 227.8 meters, 20 days after installation of the completion string. Detailed lithologic descriptions with stratigraphic assignments are included in the report. These are based on composite drill cuttings, supplemented by geophysical log data, and incorporating data from detailed chemical and mineralogical studies of rock samples. Beneath a thin alluvial deposit, the well penetrated 410 meters of lava and bedded tuff of the Volcanics of Fortymile Canyon Group, deposited in the Timber Mountain caldera moat after caldera collapse. The geologic interpretation of data from this well provides information on the thickness, lithologic composition, and hydrogeologic character of moat-filling rocks in the southern portion of the Timber Mountain caldera complex in the southwestern Nevada volcanic field.

  14. Completion Report for Well ER-EC-8

    SciTech Connect (OSTI)

    Bechtel Nevada

    2004-10-01T23:59:59.000Z

    Well ER-EC-8 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the summer of 1999 as part of the U.S. Department of Energy's hydrogeologic investigation program in the Western Pahute Mesa - Oasis Valley region just west of the Nevada Test Site. A 44.5-centimeter surface hole was drilled and cased off to a depth of 129.8 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 609.6 meters. One completion string with three isolated slotted intervals was installed in the well. A preliminary composite, static water level was measured at the depth of 98.4 meters, 24 days after installation of the completion string. Detailed lithologic descriptions with stratigraphic assignments are included in the report. These are based on evaluation of composite drill cuttings collected every 3 meters, and 20 sidewall samples taken at various depths below 157.9 meters, supplemented by geophysical log data and results of detailed chemical and mineralogical studies of rock samples. Drilling began in Tertiary-age tuff of the Thirsty Canyon Group, and penetrated tuffs of the Beatty Wash Formation, tuff of Buttonhook Wash, and the upper portion of the Ammonia Tanks Tuff. The geologic interpretation of data from this well helps define the location of the western margin of the Timber Mountain caldera complex in the southwestern Nevada volcanic field. Geologic and hydrologic data from the well will aid in development of models to predict groundwater flow and contaminant migration within and near the Nevada Test Site.

  15. Pahute Mesa Well Development and Testing Analyses for Wells ER-20-8 and ER-20-4, Nevada National Security Site, Nye County, Nevada, Revision 0

    SciTech Connect (OSTI)

    Greg Ruskauff and Sam Marutzky

    2012-09-01T23:59:59.000Z

    Wells ER-20-4 and ER-20-8 were drilled during fiscal year (FY) 2009 and FY 2010 (NNSA/NSO, 2011a and b). The closest underground nuclear test detonations to the area of investigation are TYBO (U-20y), BELMONT (U-20as), MOLBO (U-20ag), BENHAM (U-20c), and HOYA (U-20 be) (Figure 1-1). The TYBO, MOLBO, and BENHAM detonations had working points located below the regional water table. The BELMONT and HOYA detonation working points were located just above the water table, and the cavity for these detonations are calculated to extend below the water table (Pawloski et al., 2002). The broad purpose of Wells ER-20-4 and ER-20-8 is to determine the extent of radionuclide-contaminated groundwater, the geologic formations, groundwater geochemistry as an indicator of age and origin, and the water-bearing properties and hydraulic conditions that influence radionuclide migration. Well development and testing is performed to determine the hydraulic properties at the well and between other wells, and to obtain groundwater samples at the well that are representative of the formation at the well. The area location, wells, underground nuclear detonations, and other features are shown in Figure 1-1. Hydrostratigraphic cross sections A-A’, B-B’, C-C’, and D-D’ are shown in Figures 1-2 through 1-5, respectively.

  16. Electrospun nanofibers of Er{sup 3+}-doped TiO{sub 2} with photocatalytic activity beyond the absorption edge

    SciTech Connect (OSTI)

    Zheng, Yali; Wang, Wenzhong, E-mail: wzwang@mail.sic.ac.cn

    2014-02-15T23:59:59.000Z

    Er{sup 3+}-doped TiO{sub 2} nanofibers with different Er{sup 3+} contents were prepared via electrospinning and characterized by X-ray diffraction, scanning electron microscopy, ultraviolet–visible diffuse reflectance spectroscopy and photocurrent measurement. Photocatalytic activities of the as-prepared samples were evaluated by the decolorization of methyl orange aqueous solution under simulated solar light irradiation. The results indicated that the photocatalytic activity of Er{sup 3+}-doped TiO{sub 2} nanofibers was much higher than that of the undoped one, and the optimal dosage of Er{sup 3+} at 1 mol% achieved the highest degradation rate. Moreover, the photocatalytic activity of Er{sup 3+}-doped TiO{sub 2} nanofibers under the irradiation of light with the wavelength beyond the absorption edge of TiO{sub 2} was explored by the decolorization of a dye, rhodamine B and the photodegradation of a typical colorless pollutant, phenol. The results further revealed the mechanism of the enhanced photocatalytic activity through Er{sup 3+} doping in TiO{sub 2} nanofibers. - Graphical abstract: Display Omitted - Highlights: ?Er{sup 3+}:TiO{sub 2} nanofibers with different Er{sup 3+} contents were prepared via electrospinning. ?The photocatalytic activity of Er{sup 3+}:TiO{sub 2} was much higher than that of undoped one. ?Er{sup 3+}:TiO{sub 2} could be activated by the light with wavelength beyond the absorption edge.

  17. Bisphenol-A rapidly enhanced passive avoidance memory and phosphorylation of NMDA receptor subunits in hippocampus of young rats

    SciTech Connect (OSTI)

    Xu Xiaohong, E-mail: xuxh63@zjnu.cn; Li Tao; Luo Qingqing; Hong Xing; Xie Lingdan; Tian Dong

    2011-09-01T23:59:59.000Z

    Bisphenol-A (BPA), an endocrine disruptor, is found to influence development of brain and behaviors in rodents. The previous study indicated that perinatal exposure to BPA impaired learning-memory and inhibited N-methyl-D-aspartate receptor (NMDAR) subunits expressions in hippocampus during the postnatal development in rats; and in cultured hippocampal neurons, BPA rapidly promotes dynamic changes in dendritic morphology through estrogen receptor-mediated pathway by concomitant phosphorylation of NMDAR subunit NR2B. In the present study, we examined the rapid effect of BPA on passive avoidance memory and NMDAR in the developing hippocampus of Sprague-Dawley rats at the age of postnatal day 18. The results showed that BPA or estradiol benzoate (EB) rapidly extended the latency to step down from the platform 1 h after footshock and increased the phosphorylation levels of NR1, NR2B, and mitogen-activated extracellular signal-regulated kinase (ERK) in hippocampus within 1 h. While 24 h after BPA or EB treatment, the improved memory and the increased phosphorylation levels of NR1, NR2B, ERK disappeared. Furthermore, pre-treatment with an estrogen receptors (ERs) antagonist, ICI182,780, or an ERK-activating kinase inhibitor, U0126, significantly attenuated EB- or BPA-induced phosphorylations of NR1, NR2B, and ERK within 1 h. These data suggest that BPA rapidly enhanced short-term passive avoidance memory in the developing rats. A non-genomic effect via ERs may mediate the modulation of the phosphorylation of NMDAR subunits NR1 and NR2B through ERK signaling pathway. - Highlights: > BPA rapidly extended the latency to step down from platform 1 h after footshock. > BPA rapidly increased pNR1, pNR2B, and pERK in hippocampus within 1 h. > ERs antagonist or MEK inhibitor attenuated BPA-induced pNR1, pNR2B, and pERK.

  18. Green emission from Er-doped GaN grown by molecular beam epitaxy on Si substrates

    E-Print Network [OSTI]

    Steckl, Andrew J.

    Green emission from Er-doped GaN grown by molecular beam epitaxy on Si substrates R. Birkhahn and A grown by MBE on sapphire substrates. In this letter, we report on Er-doped GaN growth experiments on Si Er-doped -GaN thin films grown on Si 111 . The GaN was grown by molecular beam epitaxy using solid

  19. Carrier transport properties of nanocrystalline Er{sub 3}N@C{sub 80}

    SciTech Connect (OSTI)

    Sun, Yong, E-mail: sun@ele.kyutech.ac.jp; Maeda, Yuki; Sezaimaru, Hiroki; Sakaino, Masamichi [Department of Applied Science for Integrated System Engineering, Kyushu Institute of Technology, Senshuimachi, Tobata, Kitakyushu, Fukuoka 804-8550 (Japan); Kirimoto, Kenta [Department of Electrical and Electronic Engineering, Kitakyushu National College of Technology, 5-20-1 shii, Kokuraminami, Kitakyushu, Fukuoka 802-0985 (Japan)

    2014-07-21T23:59:59.000Z

    Electrical transport properties of the nanocrystalline Er{sub 3}N@C{sub 80} with fcc crystal structure were characterized by measuring both temperature-dependent d.c. conductance and a.c. impedance. The results showed that the Er{sub 3}N@C{sub 80} sample has characteristics of n-type semiconductor and an electron affinity larger than work function of gold metal. The Er{sub 3}N@C{sub 80}/Au interface has an ohmic contact behavior and the contact resistance was very small as compared with bulk resistance of the Er{sub 3}N@C{sub 80} sample. The charge carriers in the sample were thermally excited from various trapped levels and both acoustic phonon and ionic scatterings become a dominant process in different temperature regions, respectively. At temperatures below 250?K, the activation energy of the trapped carrier was estimated to be 35.5?meV, and the ionic scattering was a dominant mechanism. On the other hand, at temperatures above 350?K, the activation energy was reduced to 15.9?meV, and the acoustic phonon scattering was a dominant mechanism. In addition, a polarization effect from the charge carrier was observed at low frequencies below 2.0 MHz, and the relative intrinsic permittivity of the Er{sub 3}N@C{sub 80} nanocrystalline lattice was estimated to be 4.6 at frequency of 5.0 MHz.

  20. The electroluminescence mechanism of Er³? in different silicon oxide and silicon nitride environments

    SciTech Connect (OSTI)

    Rebohle, L., E-mail: l.rebohle@hzdr.de; Wutzler, R.; Braun, M.; Helm, M.; Skorupa, W. [Institute of Ion Beam Physics and Materials Research, Helmholtz-Zentrum Dresden - Rossendorf, Bautzner Landstraße 400, 01328 Dresden (Germany); Berencén, Y.; Ramírez, J. M.; Garrido, B. [Dept. Electrònica, Martí i Franquès 1, Universitat de Barcelona, 08028 Barcelona (Spain); Hiller, D. [IMTEK, Faculty of Engineering, Albert-Ludwigs-University Freiburg, Georges-Köhler-Allee 103, 79110 Freiburg (Germany)

    2014-09-28T23:59:59.000Z

    Rare earth doped metal-oxide-semiconductor (MOS) structures are of great interest for Si-based light emission. However, several physical limitations make it difficult to achieve the performance of light emitters based on compound semiconductors. To address this point, in this work the electroluminescence (EL) excitation and quenching mechanism of Er-implanted MOS structures with different designs of the dielectric stack are investigated. The devices usually consist of an injection layer made of SiO? and an Er-implanted layer made of SiO?, Si-rich SiO?, silicon nitride, or Si-rich silicon nitride. All structures implanted with Er show intense EL around 1540 nm with EL power efficiencies in the order of 2 × 10?³ (for SiO?:Er) or 2 × 10??(all other matrices) for lower current densities. The EL is excited by the impact of hot electrons with an excitation cross section in the range of 0.5–1.5 × 10?¹?cm?². Whereas the fraction of potentially excitable Er ions in SiO? can reach values up to 50%, five times lower values were observed for other matrices. The decrease of the EL decay time for devices with Si-rich SiO? or Si nitride compared to SiO? as host matrix implies an increase of the number of defects adding additional non-radiative de-excitation paths for Er³?. For all investigated devices, EL quenching cross sections in the 10?²? cm² range and charge-to-breakdown values in the range of 1–10 C cm?² were measured. For the present design with a SiO? acceleration layer, thickness reduction and the use of different host matrices did not improve the EL power efficiency or the operation lifetime, but strongly lowered the operation voltage needed to achieve intense EL.

  1. In tobacco leaf epidermal cells, the integrity of protein export from the endoplasmic reticulum and of ER export sites

    E-Print Network [OSTI]

    In tobacco leaf epidermal cells, the integrity of protein export from the endoplasmic reticulum and of ER export sites depends on active COPI machinery Giovanni Stefano1, , Luciana Renna1, , Laurent between COPI and COPII for the maintenance of ER protein export, the mechanisms by which COPI influences

  2. Vacancy-type defects in Er-doped GaN studied by a monoenergetic positron beam

    SciTech Connect (OSTI)

    Uedono, A.; Shaoqiang, C.; Jongwon, S.; Ito, K.; Nakamori, H.; Honda, N.; Tomita, S.; Akimoto, K.; Kudo, H. [Institute of Applied Physics, University of Tsukuba, Tsukuba, Ibaraki, 305-8573 (Japan); Ishibashi, S. [Research Institute for Computational Sciences, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, 305-8568 (Japan)

    2008-05-15T23:59:59.000Z

    A relationship between intra-4f transitions of Er and vacancy-type defects in Er-doped GaN was studied by using a monoenergetic positron beam. Doppler broadening spectra of the annihilation radiation were measured for Er-doped GaN grown by molecular beam epitaxy. A clear correlation between the defect concentration and the photoluminescence (PL) intensity was observed. The major defect species detected by positrons was identified as a Ga vacancy V{sub Ga}, and its concentration increased with increasing Er concentration [Er]. For the sample with [Er]=3.3 at. %, the maximum integrated intensity of PL was observed. The V{sub Ga} concentration was above 10{sup 18} cm{sup -3} and additional vacancies such as divacancies started to be introduced at this Er concentration. For the sample with higher [Er], the PL intensity decreased, and the mean size of vacancies decreased due to an introduction of precipitates and/or metastable phases.

  3. Ice Classification in the Southern Ocean Using ERS-1 Scatterometer David S.Early, David G. Long

    E-Print Network [OSTI]

    Long, David G.

    Ice Classification in the Southern Ocean Using ERS-1 Scatterometer Data David S.Early, David G for classifying Southern Ocean sea ice from enhanced resolution ERS-1 scat- terometer images is presented of a measure of the anisotropy, is used to further help delineate sea ice types. Ice 'l'ype Backscatter feange

  4. Towards an Er-doped Si nanocrystal sensitized waveguide laser the thin line between gain and loss

    E-Print Network [OSTI]

    Polman, Albert

    somehow be eliminated from this scheme, the fabrication of low-cost Si based Er doped optical amplifiers1 Towards an Er-doped Si nanocrystal sensitized waveguide laser ­ the thin line between gain-doped Si nanocrystal co-doped SiO2, a composite material that can potentially be fabricated using a VLSI

  5. Defect production in strained p-type Si{sub 1-x}Ge{sub x} by Er implantation

    SciTech Connect (OSTI)

    Mamor, M. [Instituut voor Kern-en Stralingsfysica and INPAC, Katholieke Universiteit Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Department of Physics, Sultan Qaboos University, P.O. Box 50, Muscat 123, Sultanate of Oman (Oman); Pipeleers, B.; Vantomme, A. [Instituut voor Kern-en Stralingsfysica and INPAC, Katholieke Universiteit Leuven, Celestijnenlaan 200D, B-3001 Leuven (Belgium); Auret, F. D. [Department of Physics, University of Pretoria, Pretoria 0002 (South Africa)

    2011-01-01T23:59:59.000Z

    Strained p-Si{sub 1-x}Ge{sub x} (x=5.3%, 10.2%, and 15.4%) was irradiated at room temperature with 160 keV {sup 166}Er{sup 2+} ions to a fluence of 1x10{sup 10} or 3x10{sup 13} Er/cm{sup 2}. The defects induced by ion implantation were investigated experimentally using high-resolution x-ray diffraction, Rutherford backscattering and channeling spectroscopy, and deep level transient spectroscopy. X-ray diffraction indicates that the damage induced by Er implantation produces a slight perpendicular expansion of the SiGe lattice. For all compositions, channeling measurements reveal that Er implantation in p-Si{sub 1-x}Ge{sub x} to a fluence of 3x10{sup 13} Er/cm{sup 2} induces an amorphous region below the Si{sub 1-x}Ge{sub x} surface. Annealing at 850 deg. C for 30 s, results in a reduction in damage density, a relaxation of the implantation-induced perpendicular expansion of the SiGe lattice in the implanted region, while a more pronounced relaxation of the compressive strain SiGe is observed for higher Ge content (x=0.10 and 0.15). On the other hand, for the annealed SiGe samples that were implanted with Er at the fluence of 10{sup 10} Er/cm{sup 2}, the compressive strain in the SiGe layer is nearly completely retained. Deep level transient spectroscopy studies indicate that two prominent defects with discrete energy levels above the valence band are introduced during Er implantation. Their activation energy was found to decrease with increasing Ge content. However, the relatively large local strain induced by high fluence Er implantation reduces the activation energy by 40 meV with respect to the low fluence Er implanted p-Si{sub 1-x}Ge{sub x}. This shift (40 meV) in the activation energy remains constant regardless of the Ge content, suggesting that the Si{sub 1-x}Ge{sub x} layers remained fully strained after Er implantation. The observed defects are further compared to those introduced by alpha particle irradiation and electron beam metal deposition. The results indicate that defects introduced by Er implantation have similar electronic properties as those of defects detected after electron beam deposition and alpha particle irradiation. Therefore, it is concluded that these defects are due to the Er implantation-induced damage and not to the Er species specifically.

  6. 500 ZENITNovEmbEr2010 Warmte-eilandeffect van de stad Utrecht

    E-Print Network [OSTI]

    Brandsma, Theo

    500 ZENITNovEmbEr2010 Warmte-eilandeffect van de stad Utrecht Foto: Eclipse Ballooning, www waargenomen opwarming van de aarde. Het KNMI heeft daarom mobiele metingen ver- richt in de stad Utrecht. De indicatie van het effect van het warmte-eiland van de stad Utrecht op de temperatuur in De Bilt. W armte

  7. Gain Improvement of Er-doped Amplifiers for the Feedback Filters

    E-Print Network [OSTI]

    Song, Xiaomin

    2012-02-14T23:59:59.000Z

    contrast between these two materials and the electro-optical properties of Ti: LiNbO3. Furthermore, waveguide gain is introduced through selective surface erbium (Er) doping which yields high quality loss-compensated or even amplifying waveguides without...

  8. Een robotvogel die zo natuurge-trouw vliegt dat andere vogels er

    E-Print Network [OSTI]

    Twente, Universiteit

    bewegen. Die spieren kun je niet allemaal nabootsen in een kleine robot. Dus komt er flink wat analyse aan te pas om toch een robot te ontwerpen die levensecht vliegt. Die van Nijenhuis vliegt op een accu en.clearflightsolutions.com DOOR Christian Jongeneel fOtOgRafie Gijs van Ouwerkerk spin-Off RObOtvOGel "In de varianten valk en

  9. RisNyt NO1 2005 "Det globale brintsamfund er et langsigtet

    E-Print Network [OSTI]

    bæredygtigt brint- samfund. Arbejdet udføres under European Fuel Cell and Hydrogen Platform, som er på vej med." Sådan beskriver afdelings- chef Hans Larsen budskabet fra International Hydrogen Day i Berlin, hvor han gaffeltruck. Amtet har bevilget 3,75 millioner kr. i årene 2004-2006 til Hydrogen Innovation & Research Centre

  10. 76 PostErs EMBnet.journal 19.B An ontology describing congenital heart defects data

    E-Print Network [OSTI]

    76 PostErs EMBnet.journal 19.B An ontology describing congenital heart defects data Charalampos interests: the authors have declared that no competing interests exist. Abstract Congenital heart defects (CHDs) are a group of diseases characterized by a structural anomaly of the heart that is pre- sent

  11. Synthesis of multiferroic Er-Fe-O thin films by atomic layer and chemical vapor deposition

    SciTech Connect (OSTI)

    Mantovan, R., E-mail: roberto.mantovan@mdm.imm.cnr.it; Vangelista, S.; Wiemer, C.; Lamperti, A.; Tallarida, G. [Laboratorio MDM IMM-CNR, I-20864 Agrate Brianza (MB) (Italy); Chikoidze, E.; Dumont, Y. [GEMaC, Université de Versailles St. Quentin en Yvelines-CNRS, Versailles (France); Fanciulli, M. [Laboratorio MDM IMM-CNR, I-20864 Agrate Brianza (MB) (Italy); Dipartimento di Scienza dei Materiali, Università di Milano Bicocca, Milano (Italy)

    2014-05-07T23:59:59.000Z

    R-Fe-O (R?=?rare earth) compounds have recently attracted high interest as potential new multiferroic materials. Here, we report a method based on the solid-state reaction between Er{sub 2}O{sub 3} and Fe layers, respectively grown by atomic layer deposition and chemical vapor deposition, to synthesize Er-Fe-O thin films. The reaction is induced by thermal annealing and evolution of the formed phases is followed by in situ grazing incidence X-ray diffraction. Dominant ErFeO{sub 3} and ErFe{sub 2}O{sub 4} phases develop following subsequent thermal annealing processes at 850?°C in air and N{sub 2}. Structural, chemical, and morphological characterization of the layers are conducted through X-ray diffraction and reflectivity, time-of-flight secondary ion-mass spectrometry, and atomic force microscopy. Magnetic properties are evaluated by magnetic force microscopy, conversion electron Mössbauer spectroscopy, and vibrating sample magnetometer, being consistent with the presence of the phases identified by X-ray diffraction. Our results constitute a first step toward the use of cost-effective chemical methods for the synthesis of this class of multiferroic thin films.

  12. Effect of Er doping on the structural and magnetic properties of cobalt-ferrite

    SciTech Connect (OSTI)

    Prathapani, Sateesh; Vinitha, M.; Das, D., E-mail: ddse@uohyd.ernet.in [School of Engineering Sciences and Technology, University of Hyderabad, Hyderabad 500046 (India); Jayaraman, T. V. [Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, Nebraska 68588 (United States)

    2014-05-07T23:59:59.000Z

    Nanocrystalline particulates of Er doped cobalt-ferrites CoFe{sub (2?x)}Er{sub x}O{sub 4} (0???x???0.04), were synthesized, using sol-gel assisted autocombustion method. Co-, Fe-, and Er- nitrates were the oxidizers, and malic acid served as a fuel and chelating agent. Calcination (400–600?°C for 4?h) of the precursor powders was followed by sintering (1000?°C for 4?h) and structural and magnetic characterization. X-ray diffraction confirmed the formation of single phase of spinel for the compositions x?=?0, 0.01, and 0.02; and for higher compositions an additional orthoferrite phase formed along with the spinel phase. Lattice parameter of the doped cobalt-ferrites was higher than that of pure cobalt-ferrite. The observed red shift in the doped cobalt-ferrites indicates the presence of induced strain in the cobalt-ferrite matrix due to large size of the Er{sup +3} compared to Fe{sup +3}. Greater than two-fold increase in coercivity (?66?kA/m for x?=?0.02) was observed in doped cobalt-ferrites compared to CoFe{sub 2}O{sub 4} (?29?kA/m)

  13. That which does not kill me makes me stronger: adapting to chronic ER stress

    E-Print Network [OSTI]

    Bedwell, David M.

    by activating signal transduction cascades that improve protein folding. One example of such a cascade is the unfolded protein response (UPR), which senses protein folding stress in the endoplasmic reticulum (ER) and leads to improvement in the protein folding and proces- sing capacity of the organelle. A central

  14. Global observations of UV-absorbing aerosols from ERS-2/GOME Data

    E-Print Network [OSTI]

    Graaf, Martin de

    Global observations of UV-absorbing aerosols from ERS-2/GOME Data Martin de Graaf Piet Stammes Absorbing Aerosol Index ­ Theory GOME AAI results Conclusions & Outlook #12; Absorbing Aerosol Index; Rayleigh (multiple) scattering clouds aerosols surface Top Of Atmosphere incoming radiation outgoing

  15. ? "Y SILF: WE,ASIiER ? Mailed Mov. 15, 1934 A Science Service Feature

    E-Print Network [OSTI]

    of polr?er, t o the humidity and under extreme atmosi3heric conditions t?cy mount t o 30 per Cent. According t o the United States Bureau of Standards this idea sulting from the lubrication of the sprint be obtained under conditions of high humidity.a ( A l l rights reserved by Science Service, Inc,) u - - I

  16. Imrovements to Platt's SMO Algorithm for SVM Classi er Design 1

    E-Print Network [OSTI]

    Keerthi, S. Sathiya

    Imrovements to Platt's SMO Algorithm for SVM Classi#12;er Design 1 S.S. Keerthi S.K. Shevade CÃ?ciency in Platt's Sequential Minimal Optimization (SMO) algorithm that is caused by the use of a single threshold have been suggested[9,4,7,3,6]. Platt's Sequential Minimization Algorithm (SMO)[9,11] is an important

  17. MinErAl prEpArAtion EnginEEring

    E-Print Network [OSTI]

    Hartman, Chris

    MinErAl prEpArAtion EnginEEring College of Engineering and Mines Department of Mining ­ 36 credits The mineral preparation engineering program offers specialization in the processes used to concentrate target minerals and remove undesir- able material from mined ore. Interdisciplinary study

  18. TOWARDS A SEMASIOLOGICAL ACCOUNT OF EVIDENTIALS: AN ENUNCIATIVE APPROACH OF ER IN MODERN WESTERN ARMENIAN

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    TOWARDS A SEMASIOLOGICAL ACCOUNT OF EVIDENTIALS: AN ENUNCIATIVE APPROACH OF ­ER IN MODERN WESTERN ARMENIAN Anaïd Donabédian Modern Western Armenian1 (henceforth MWA) has a specific form of completed past observed in MWA coincide with those found in descriptions of Balkan and Caucasian languages, commonly

  19. Environmental and Resource Studies Program Books, Maps & Videos Available For Use in ERS Courses

    E-Print Network [OSTI]

    Fox, Michael

    Environmental and Resource Studies Program Books, Maps & Videos Available For Use in ERS Courses find and/or purchase it. We will try to accommodate every request, but resources are generally Bioenergetics 3.0 Focus on Peatlands and Peat Mosses Forest Ecology Forest Ecology- Foundation for Sustainable

  20. ALGEBRA LINEAL I 1er Curso de CC. Fisicas. Examen Final. 4 de Febrero de 2005.

    E-Print Network [OSTI]

    Guijarro, Luis

    ´ALGEBRA LINEAL I 1er Curso de CC. F´isicas. Examen Final. 4 de Febrero de 2005. Apellidos: Nombre aplicaci´on lineal f : R3 R3 tal que Kerf = Nf x -y = 0 y -z = 0 Imf x + 2y + 3z = 0. 4. Sean L, U y B

  1. Evaluation of ERS Scatterometer soil moisture products over a half-degree region in Southwestern France

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    . Based on a high resolution soil moisture simulation (1km²) validated at the local scale, the ERS in the water and energy exchanges between the land surface and the atmosphere. Several authors have shown027231 #12;Aeronautics and Space Administration (NASA) sensors such as the AMSR-E radiometer (since 2002

  2. SMG on SMP Clusters: Performance Issues Sue Goudy, Lorie Liebrock, and Steve Scha#er

    E-Print Network [OSTI]

    SMG on SMP Clusters: Performance Issues Sue Goudy, Lorie Liebrock, and Steve Scha#er New Mexico Institute of Mining and Technology Socorro, New Mexico 87801 spgoudy@nmt.edu February 3, 2003 Abstract be a high speed interconnect as in Intel Teraflops or some relatively slow connection such as ethernet

  3. Extending ER Models to Capture Database Transformations to Build Data Sets for Data Mining

    E-Print Network [OSTI]

    Ordonez, Carlos

    transformation tables in abstract form can be useful not only for optimizing the generation of new data sets stages of data transformation, mathematical functions and the powerful SQL CASE statement, which doesExtending ER Models to Capture Database Transformations to Build Data Sets for Data Mining Carlos

  4. Multi-date ERS tandem interferogram analysis: application to alpine glaciers

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Multi-date ERS tandem interferogram analysis: application to alpine glaciers Lionel Bombrun, Ivan P.landes@insa-strasbourg.fr Abstract--Temperate glaciers are an indicator of the local effects of global climate change. For economical to detect significant changes and to constrain glacier flow models. In this paper, five descending one

  5. 25RIS N Y T 2/01 Fremtidens mlle er stor og vindomsust

    E-Print Network [OSTI]

    avancerede forsknings- og udviklingsområder, vi overhovedet har i Danmark. siger Peter Hjuler Jensen (tv). Vi avancerede forsknings- og udviklingsområder, vi overhovedet har i Danmark. Man kan så glæde sig over, at Dan århundrede stædigt har holdt fast ved, at vindenergi er værd at satse på, står Danmark stærkt. Det gæl- der

  6. "Omprioriteringen af Riss forskningsvirke er en enestende chance for endelig at

    E-Print Network [OSTI]

    at give Danmark et selvstændigt nationalt forskningscenter, der på én gang er forank- ret i grundforskning omprioriteringen af Risøs forsknings- virke betyder til gengæld en enestå- ende chance for endelig at give Danmark haft Danmarks udvikling på sinde Allerede i sine studieår, hvor Haldor Topsøe læste på Danmarks

  7. Indledning Velkommen til Microsoft . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Side 4 Inspiration Vi er drevet af passion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Side 8

    E-Print Network [OSTI]

    Hunt, Galen

    af software og it-løsninger . Siden 1990 har Microsoft været repræsenteret i Danmark, hvor vi i dag Danmark kombinerer det bedste fra to verdener: det ameri- kanske fokus på performance og talentudvikling,fleksibilitetogklaremålervoresDNA. Hos Microsoft Danmark er vi 450 medarbejdere med vidt forskellige baggrunde og kompetenc

  8. Salt Accumulation in the Loessial Sequence in the Be'er Sheva Basin, Israel

    E-Print Network [OSTI]

    Gvirtzman, Haim

    Salt Accumulation in the Loessial Sequence in the Be'er Sheva Basin, Israel MORDECKAIMAGARr / Evidence of climatic changes is recorded in the salt content of the surface sediments in arid zones, In wetter periods airborne salts are removed downward by leaching to the groundwater, whereas in drier

  9. Propostes temes del treball sobre ER Treball sobre una font d'energia renovable

    E-Print Network [OSTI]

    Batiste, Oriol

    Propostes temes del treball sobre ER Treball sobre una font d'energia renovable Estudi de l'estat de desenvolupament, la implantaci´o i evoluci´o hist`orica d'u- na font d'energia renovable concreta: · Solar fotovoltaica · Solar trmica · Biocombustibiles · Elica Treball sobre una tecnologia espec

  10. UC Santa Cruz Review / Fall 2005 17 er plants by converting waste

    E-Print Network [OSTI]

    Zhang, Yi

    UC Santa Cruz Review / Fall 2005 17 er plants by converting waste heat to electricity. But first's engine will be wasted as heat, while only one- third will actually be used to get you where you want so that "hot" electrons that have absorbed energy from a heat source can flow more easily than "cold

  11. Magnetism of Ho and Er Atoms on Close-Packed Metal Surfaces F. Donati,1

    E-Print Network [OSTI]

    Thévenaz, Jacques

    Magnetism of Ho and Er Atoms on Close-Packed Metal Surfaces F. Donati,1 A. Singha,1 S. Stepanow,2 C; published 3 December 2014) We investigated the magnetic properties of individual Ho atoms adsorbed on the (111) surface of Pt, which have been recently claimed to display single ion magnetic behavior

  12. Excellent optical thermometry based on short-wavelength upconversion emissions in Er3

    E-Print Network [OSTI]

    Cao, Wenwu

    Excellent optical thermometry based on short-wavelength upconversion emissions in Er3 Yb3 codoped (Doc. ID 175753); published November 22, 2012 Excited by a 980 nm laser, upconversion emissions coupled levels, which can emit the shortest wavelength emissions for optical thermometry known so far

  13. Melting of small Arctic ice caps observed from ERS scatterometer time series

    E-Print Network [OSTI]

    Smith, Laurence C.

    Melting of small Arctic ice caps observed from ERS scatterometer time series Laurence C. Smith,1 of melt onset can be observed over small ice caps, as well as the major ice sheets and multi-year sea ice for 14 small Arctic ice caps from 1992­2000. Interannual and regional variability in the timing of melt

  14. Selective modification of the Er3 4 I112 branching ratio by energy

    E-Print Network [OSTI]

    Polman, Albert

    an investigation of Er3 photoluminescence in Y2O3 waveguides codoped with Eu3 . As a function of europium show that this is due to an energy transfer from the 4 I11/24 I13/2 transition in erbium to europium/2 emission is obtained for europium concentrations between 0.1 and 0.3 at. %. In addition

  15. Activation of calcium-sensing receptor increases TRPC3 expression in rat cardiomyocytes

    SciTech Connect (OSTI)

    Feng, Shan-Li [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)] [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China); Sun, Ming-Rui [Department of Pharmacology, Qiqihaer Medical College, Qiqihaer 160001 (China)] [Department of Pharmacology, Qiqihaer Medical College, Qiqihaer 160001 (China); Li, Ting-Ting; Yin, Xin [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)] [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China); Xu, Chang-Qing [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China)] [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Sun, Yi-Hua, E-mail: syh200415@126.com [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)] [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)

    2011-03-11T23:59:59.000Z

    Research highlights: {yields} Calcium-sensing receptor (CaR) activation stimulates TRP channels. {yields} CaR promoted transient receptor potential C3 (TRPC3) expression. {yields} Adult rat ventricular myocytes display capacitative calcium entry (CCE), which was operated by TRPCs. {yields} TRPC channels activation induced by CaR activator sustained the increased [Ca{sup 2+}]{sub i} to evoke cardiomyocytes apoptosis. -- Abstract: Transient receptor potential (TRP) channels are expressed in cardiomyocytes, which gate a type of influx of extracellular calcium, the capacitative calcium entry. TRP channels play a role in mediating Ca{sup 2+} overload in the heart. Calcium-sensing receptors (CaR) are also expressed in rat cardiac tissue and promote the apoptosis of cardiomyocytes by Ca{sup 2+} overload. However, data about the link between CaR and TRP channels in rat heart are few. In this study, reverse transcriptase polymerase chain reaction (RT-PCR) and Western blotting were used to examine the expression of the TRP canonical proteins TRPC1 and TRPC3 in adult and neonatal rat cardiomyocytes. Laser scan confocal microscopy was used to detect intracellular [Ca{sup 2+}]{sub i} levels in isolated adult rat ventricular myocytes. The results showed that, in adult rat cardiomyocytes, the depletion of Ca{sup 2+} stores in the endoplasmic/sarcoplasmic reticulum (ER/SR) by thapsigargin induced a transient increase in [Ca{sup 2+}]{sub i} in the absence of [Ca{sup 2+}]{sub o} and the subsequent restoration of [Ca{sup 2+}]{sub o} sustained the increased [Ca{sup 2+}]{sub i} for a few minutes, whereas, the persisting elevation of [Ca{sup 2+}]{sub i} was reduced in the presence of the TRPC inhibitor SKF96365. The stimulation of CaR by its activator gadolinium chloride (GdCl{sub 3}) or spermine also resulted in the same effect and the duration of [Ca{sup 2+}]{sub i} increase was also shortened in the absence of [Ca{sup 2+}]{sub o}. In adult and neonatal rat cardiomyocytes, GdCl{sub 3} increased the expression of TRPC3 mRNA and protein, which were reversed by SKF96365 but not by inhibitors of the L-type channels and the Na{sup +}/Ca{sup 2+} exchangers. However, GdCl{sub 3} had no obvious effect on the expression of TRPC1 protein. These results suggested that CaR stimulation induced activation of TRP channels and promoted the expression of TRPC3, but not TRPC1, that sustained the increased [Ca{sup 2+}]{sub i}.

  16. Selective emission and luminescence of Er{sub 2}O{sub 3} under intense laser excitation

    SciTech Connect (OSTI)

    Marchenko, V M; Studenikin, M I [A M Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow (Russian Federation); Iskhakova, L D [Fiber Optics Research Center, Russian Academy of Sciences, Moscow (Russian Federation)

    2013-09-30T23:59:59.000Z

    The microstructure of Er{sub 2}O{sub 3} polycrystals synthesised by laser heating is studied. The synthesis of erbium silicate (Er{sub 2}SiO{sub 5}) layers was observed upon interaction of Er{sub 2}O{sub 3} and SiO{sub 2} melts. The dependences of the selective emission (SE) and luminescence spectra of Er{sub 2}O{sub 3} polycrystals in the range 200 – 1700 nm on the intensity of laser-thermal (at the wavelength ? = 10.6 ?m) and resonant laser (? ? 975 nm) excitation are investigated. The emission of heated Er{sub 2}O{sub 3} polycrystals arises as a result of multiphonon relaxation of absorbed energy and is a superposition of the SE at the electronic-vibrational transitions of Er{sup 3+} ions and the thermal radiation of the crystal lattice. The shape of the SE spectra of Er{sub 2}O{sub 3} polycrystals in the range 400 – 1700 nm almost does not change upon laser-thermal heating from 300 to 1500 K and subsequent cooling and corresponds to the absorption spectra of Er{sup 3+} ions. With increasing temperature, the thermal radiation intensity increases faster than the SE intensity, and the shape of the Er{sub 2}O{sub 3} spectrum becomes closer to the calculated spectrum of a blackbody. The anti-Stokes luminescence spectra of Er{sup 3+} ions formed under intense laser excitation of the {sup 4}I{sub 11/2} level are explained by additional SE caused by heating of the crystal matrix due to the Stokes losses. A difference between the SE and luminescence spectra is observed at low intensities of resonant laser excitation and low temperatures, when only the Stokes luminescence occurs. The temperature dependences of the SE and luminescence spectra of Er{sub 2}O{sub 3} upon laser excitation testify to the fundamental role played by the interaction of the electronic f-shell of Er{sup 3+} ions with crystal lattice vibrations in the processes of multiphonon radiative and nonradiative relaxation. The laser-thermal synthesis is promising for inprocess variation of the chemical composition of rare-earth samples. (interaction of laser radiation with matter)

  17. High multi-photon visible upconversion emissions of Er{sup 3+} singly doped BiOCl microcrystals: A photon avalanche of Er{sup 3+} induced by 980?nm excitation

    SciTech Connect (OSTI)

    Li, Yongjin; Song, Zhiguo, E-mail: songzg@kmust.edu.cn; Li, Chen; Wan, Ronghua; Qiu, Jianbei; Yang, Zhengwen; Yin, Zhaoyi; Yang, Yong; Zhou, Dacheng; Wang, Qi [School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093 (China)] [School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093 (China)

    2013-12-02T23:59:59.000Z

    Under 980?nm excitation, high multi-photon upconversion (UC) emission from the {sup 2}H{sub 11/2}/{sup 4}S{sub 3/2} (green) and {sup 4}F{sub 9/2} (red) levels of Er{sup 3+} ions were observed from Er{sup 3+} singly doped BiOCl microcrystals. These high-energy excited states were populated by a three to ten photon UC process conditionally, which depended on the pump power density and the Er{sup 3+} ion doping concentration, characterizing as a hetero-looping enhanced energy transfer avalanche UC process. UC emission lifetime and Raman analysis suggest that the unusual UC phenomena are initiated by the new and intense phonon vibration modes of BiOCl lattices due to Er{sup 3+} ions doping.

  18. Photonic crystal light emitting diode based on Er and Si nanoclusters co-doped slot waveguide

    SciTech Connect (OSTI)

    Lo Savio, R.; Galli, M.; Liscidini, M.; Andreani, L. C. [Dipartimento di Fisica, Università di Pavia, Via Bassi 6, 27100 Pavia (Italy); Franzò, G.; Iacona, F.; Miritello, M. [MATIS-IMM CNR and Dipartimento di Fisica e Astronomia, Università di Catania, via S. Sofia 64, 95123 Catania (Italy); Irrera, A. [CNR-IPCF, Viale Ferdinando Stagno d'Alcontres 37, 98158 Messina (Italy); Sanfilippo, D.; Piana, A. [ST Microelectronics, Stradale Primosole 50, 95121 Catania (Italy); Priolo, F. [MATIS-IMM CNR and Dipartimento di Fisica e Astronomia, Università di Catania, via S. Sofia 64, 95123 Catania (Italy); Scuola Superiore di Catania, Università di Catania, Via Valdisavoia 9, 95123 Catania (Italy)

    2014-03-24T23:59:59.000Z

    We report on the design, fabrication, and electro-optical characterization of a light emitting device operating at 1.54??m, whose active layer consists of silicon oxide containing Er-doped Si nanoclusters. A photonic crystal (PhC) is fabricated on the top-electrode to enhance the light extraction in the vertical direction, and thus the external efficiency of the device. This occurs if a photonic mode of the PhC slab is resonant with the Er emission energy, as confirmed by theoretical calculations and experimental analyses. We measure an increase of the extraction efficiency by a factor of 3 with a high directionality of light emission in a narrow vertical cone. External quantum efficiency and power efficiency are among the highest reported for this kind of material. These results are important for the realization of CMOS-compatible efficient light emitters at telecom wavelengths.

  19. Paleocene and Lower Eocene Ostracoda from the Umm er Radhuma Formation of Suadi Arabia

    E-Print Network [OSTI]

    Al-Furiah, A. A. F.

    1983-09-21T23:59:59.000Z

    °53'24" E. to lat 27 0 59' N., long 45°2748" E.). The rate of deposition was greater to the north of the reference sec- tion, shown by the thickness in Safaniya W-3. The upper contact of the Umm er Rad- 2 The University of Kansas Paleontological... Contributions—Paper 107 Table 1. Thicknesses (in feet) of the Umm er Radhuma Formation based on Well Measurements. Well Lat. Long. Thick-ness ST-23 23°36' 51°17' 1,105 S-I132 23°44' 48°53' 1,130 G. Uthmaniyah VV-4 25°113' 49°00' 880 S-710 VVVV 25°13' 48°21' 680...

  20. PROBLEMES ER (TERMODIN`AMICA) Els problemes proposats pretenen exemplificar les implicacions dels principis b`asics

    E-Print Network [OSTI]

    Batiste, Oriol

    PROBLEMES ER (TERMODIN`AMICA) Els problemes proposats pretenen exemplificar les implicacions dels principis b`asics de la termodin`amica en processos de conversi´o d'energia rellevants per a l

  1. Amorphous Diamond Flat Panel Displays - Final Report of ER-LTR CRADA project with SI Diamond Technology

    E-Print Network [OSTI]

    Ager III, Joel W.

    1998-01-01T23:59:59.000Z

    Department of Energy under a CRADA (Cooperative Research andnm in size. Page 4 of 7 SIDT CRADA Final Report In order toFinal report of ER-LTR CRADA Project Lawrence Berkeley

  2. Genome sequence of the Brown Norway rat yields insights into

    E-Print Network [OSTI]

    Pachter, Lior

    Genome sequence of the Brown Norway rat yields insights into mammalian evolution Rat Genome Norway (BN) rat strain. The sequence represents a high-quality `draft' covering over 90% of the genome

  3. Water Retrieval by Norway Rats: Behavior as Deduction

    E-Print Network [OSTI]

    Wallace, R J

    1998-01-01T23:59:59.000Z

    1948). Burrows and feeding of the Norway a radial Mammalogy,Object retrieval preferences of Norway rats: An evolutionaryinedible objects by Norway rats: Motivational interactions

  4. albino rats rattus: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia Biology and...

  5. albino rat cfn: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia Biology and...

  6. albino wistar rats: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia Biology and...

  7. albino rats exposed: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia Biology and...

  8. albino rat anatomical: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia Biology and...

  9. Physics Today Shlomo Alexander

    E-Print Network [OSTI]

    Witten, Thomas A.

    of Electrical and Electronics Engineers. The nuclear medicine division of Mallinckrodt Inc, in Petten, The Neth

  10. Inner Mongolia Bayannao er Fuhui Wind Power Co Ltd | Open Energy

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual Siteof Energy 2,AUDIT REPORTEnergyFarms AHefeiHydroenergyInformation Bayannao er Fuhui

  11. Audit Report: ER-B-00-03 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed off Energy.gov. Are you0 ARRA NewslettersPartnership1/08DOE/IG-0930 Audit Report:ER-B-00-03 Audit

  12. Audit Report: ER-B-95-04 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed off Energy.gov. Are you0 ARRA NewslettersPartnership1/08DOE/IG-0930 Audit Report:ER-B-00-03

  13. Audit Report: ER-B-98-05 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed off Energy.gov. Are you0 ARRA NewslettersPartnership1/08DOE/IG-0930 Audit5-06 AuditER-B-98-05 Audit

  14. Audit Report: ER-B-98-07 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed off Energy.gov. Are you0 ARRA NewslettersPartnership1/08DOE/IG-0930 Audit5-06 AuditER-B-98-05

  15. Audit Report: ER-B-98-08 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed off Energy.gov. Are you0 ARRA NewslettersPartnership1/08DOE/IG-0930 Audit5-06 AuditER-B-98-058-08

  16. Combined Final Technical Report 04ER86191 H2Cryo.pdf

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItem Not Found Item Not Found The itemAIR57451 Clean Energy Technologies A!FG02-04ER86191

  17. Audit Report: ER-B-95-05 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation3 AuditMA-95-02ER-B-95-05 Audit

  18. Audit Report: ER-B-96-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation3 AuditMA-95-02ER-B-95-05

  19. Audit Report: ER-B-97-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation3 AuditMA-95-02ER-B-95-057-02 Audit

  20. Audit Report: ER-B-98-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation3 AuditMA-95-02ER-B-95-057-02 Audit2

  1. Audit Report: ER-B-98-03 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation3 AuditMA-95-02ER-B-95-057-02

  2. Audit Report: ER-B-98-06 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation38-06 Audit Report: ER-B-98-06 April

  3. Audit Report: ER-B-98-07 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation38-06 Audit Report: ER-B-98-06

  4. USACE ER 200-2-2 Procedures for Implementing NEPA | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro IndustriesTown of Ladoga, IndianaTurtle Airships JumpTypefor Africa |Green6NFCRCOpenSEIA|ER

  5. Absence of exchange interaction between localized magnetic moments and conduction-electrons in diluted Er{sup 3+} gold-nanoparticles

    SciTech Connect (OSTI)

    Lesseux, G. G., E-mail: lesseux@ifi.unicamp.br; Urbano, R. R. [Instituto de Física “Gleb Wataghin,” UNICAMP, 13083-859 Campinas, São Paulo (Brazil); Iwamoto, W. [Instituto de Física “Gleb Wataghin,” UNICAMP, 13083-859 Campinas, São Paulo (Brazil); Instituto de Física, UFU, 38400-902 Uberlândia, Minas Gerais (Brazil); García-Flores, A. F. [Centro de Ciências Naturais e Humanas, UFABC, 09210-971 Santo André, São Paulo (Brazil); Rettori, C. [Instituto de Física “Gleb Wataghin,” UNICAMP, 13083-859 Campinas, São Paulo (Brazil); Centro de Ciências Naturais e Humanas, UFABC, 09210-971 Santo André, São Paulo (Brazil)

    2014-05-07T23:59:59.000Z

    The Electron Spin Resonance (ESR) of diluted Er{sup 3+} magnetic ions in Au nanoparticles (NPs) is reported. The NPs were synthesized by reducing chloro triphenyl-phosphine gold(I) and erbium(III) trifluoroacetate. The Er{sup 3+} g-value along with the observed hyperfine splitting indicate that the Er{sup 3+} impurities are in a local cubic symmetry. Furthermore, the Er{sup 3+} ESR spectra show that the exchange interaction between the 4f and the conduction electrons (ce) is absent or negligible in Au{sub 1–x}Er{sub x} NPs, in contrast to the ESR results in bulk Au{sub 1–x}Er{sub x}. Therefore, the nature of this interaction needs to be reexamined at the nano scale range.

  6. Coupling of Er light emissions to plasmon modes on In{sub 2}O{sub 3}: Sn nanoparticle sheets in the near-infrared range

    SciTech Connect (OSTI)

    Matsui, Hiroaki, E-mail: hiroaki@ee.t.u-tokyo.ac.jp; Tabata, Hitoshi [Department of Bioengineering, The University of Tokyo, 1-3-7 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan); Department of Electrical Engineering and Information Systems, The University of Tokyo, 1-3-7 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan); Badalawa, Wasanthamala; Nomura, Wataru; Yatsui, Takashi; Ohtsu, Motoichi [Department of Electrical Engineering and Information Systems, The University of Tokyo, 1-3-7 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan); Hasebe, Takayuki [Central Customs Laboratory, Ministry of Finance, 5-3-6 Kashiwanoha, Kashiwa, Chiba 270-0882 (Japan); Furuta, Shinya [Tomoe Works Co. Ltd., 1-3-6 Namiyoke, Minato-ku, Osaka 552-0001 (Japan)

    2014-07-28T23:59:59.000Z

    Near-infrared Er photoluminescence (PL) is markedly modified using a plasmonic In{sub 2}O{sub 3}: Sn nanoparticle (NP) sheet. Modeling and optical measurements reveal the presence of different electric fields (E-field) in the NP sheet. The local E-field excited at the interface between the NP sheet and Er-emitting layer of ZnO contributes significantly towards the spectral modifications of Er PL due to matching with the photon energy of Er PL. We also determine the critical temperature for Er PL modifications, which is related to the energy transfer efficiency between Er transition dipoles in ZnO and the plasmon modes on the NP sheet.

  7. Er{sup 3+}/Yb{sup 3+}co-doped bismuth molybdate nanosheets upconversion photocatalyst with enhanced photocatalytic activity

    SciTech Connect (OSTI)

    Adhikari, Rajesh; Gyawali, Gobinda; Cho, Sung Hun [Research Center for Eco-Multifunctional Nanomaterials, Sun Moon University (Korea, Republic of); Narro-García, R. [Centro de Investigaciones en Óptica, A. P.1-948, León, Gto. 37150, México (Mexico); Sekino, Tohru [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University (Japan); Lee, Soo Wohn, E-mail: swlee@sunmoon.ac.kr [Research Center for Eco-Multifunctional Nanomaterials, Sun Moon University (Korea, Republic of)

    2014-01-15T23:59:59.000Z

    In this paper, we report the microwave hydrothermal synthesis of Er{sup 3+}/Yb{sup 3+} co-doped Bi{sub 2}MoO{sub 6} upconversion photocatalyst. Crystal structure, morphology, elemental composition, optical properties and BET surface area were analyzed in detail. Infrared to visible upconversion luminescence at 532 nm and 546 nm of the co-doped samples was investigated under excitation at 980 nm. The results revealed that the co-doping of Er{sup 3+}/Yb{sup 3+} into Bi{sub 2}MoO{sub 6} exhibited enhanced photocatalytic activity for the decomposition of rhodamine B under simulated solar light irradiation. Enhanced photocatalytic activity can be attributed to the energy transfer between Er{sup 3+}/Yb{sup 3+} and Bi{sub 2}MoO{sub 6} via infrared to visible upconversion from Er{sup 3+}/Yb{sup 3+} ion and higher surface area of the Bi{sub 2}MoO{sub 6} nanosheets. Therefore, this synthetic approach may exhibit a better alternative to fabricate upconversion photocatalyst for integral solar light absorption. - Graphical abstract: Schematic illustration of the upconversion photocatalysis. Display Omitted - Highlights: • Er{sup 3+}/Yb{sup 3+} co-doped Bi{sub 2}MoO{sub 6} upconversion photocatalyst is successfully synthesized. • We obtained the nanosheets having high surface area. • Upconversion of IR to visible light was confirmed. • Upconversion phenomena can be utilized for effective photocatalysis.

  8. Atelier " i l ti ri e e l i e e ilie lli i el " e re er t ire e ri

    E-Print Network [OSTI]

    Passot, Thierry

    Atelier " i l ti ri e e l i e e ilie lli i el " e re er t ire e ri A r e i ti e A r e l i e ti l i e et le r l e e l er et re l i " le i ti e" i i t er e i i e r le l r e elle ti te relle t et r r el t li #12; Atelier " i l ti ri e e l i e e ilie lli i el " e re er t ire e ri

  9. The role of Nb in intensity increase of Er ion upconversion luminescence in zirconia

    SciTech Connect (OSTI)

    Smits, K., E-mail: smits@cfi.lu.lv; Sarakovskis, A.; Grigorjeva, L.; Millers, D. [Institute of Solid State Physics, University of Latvia, 8 Kengaraga Str., Riga LV1063 (Latvia); Grabis, J. [Institute of Inorganic Chemistry, Riga Technical University, Salaspils-1 LV2169 (Latvia)

    2014-06-07T23:59:59.000Z

    It is found that Nb co-doping increases the luminescence and upconversion luminescence intensity in rare earth doped zirconia. Er and Yb-doped nanocrystalline samples with or without Nb co-doping were prepared by sol-gel method and thermally annealed to check for the impact of phase transition on luminescence properties. Phase composition and grain sizes were examined by X-ray diffraction; the morphology was checked by scanning- and high-resolution transmission electron microscopes. Both steady-state and time-resolved luminescence were studied. Comparison of samples with different oxygen vacancy concentrations and different Nb concentrations confirmed the known assumption that oxygen vacancies are the main agents for tetragonal or cubic phase stabilization. The oxygen vacancies quench the upconversion luminescence; however, they also prevent agglomeration of rare-earth ions and/or displacement of rare-earth ions to grain surfaces. It is found that co-doping with Nb ions significantly (>20 times) increases upconversion luminescence intensity. Hence, ZrO{sub 2}:Er:Yb:Nb nanocrystals may show promise for upconversion applications.

  10. Atomistic simulation of Er irradiation induced defects in GaN nanowires

    SciTech Connect (OSTI)

    Ullah, M. W., E-mail: mohammad.ullah@helsinki.fi; Kuronen, A.; Djurabekova, F.; Nordlund, K. [Department of Physics, University of Helsinki, P.O. Box 64, FIN-00014 (Finland); Stukowski, A. [Technische Universität Darmstadt, 64287 Darmstadt (Germany)

    2014-09-28T23:59:59.000Z

    Classical molecular dynamics simulation was used to irradiate a GaN nanowire with rear-earth erbium (Er). Ten cumulative irradiations were done using an ion energy of 37.5?keV on a 10?×?10?nm{sup 2} surface area which corresponds to a fluence of 1?×?10{sup 13?}cm{sup ?2}. We studied the location and types of defects produced in the irradiation. Er implantation leads to a net positive (expansion) strain in the nanowire and especially at the top region a clear expansion has been observed in the lateral and axial directions. The lattice expansion is due to the hydrostatic strain imposed by a large number of radiation induced defects at the top of the NW. Due to the large surface-to-volume ratio, most of the defects were concentrated at the surface region, which suggests that the experimentally observed yellow luminescence (YL) in ion implanted GaN NWs arises from surface defects. We observed big clusters of point defects and vacancy clusters which are correlated with stable lattice strain and the YL band, respectively.

  11. Monitoring change in the Bering Glacier region, Alaska: Using Landsat TM and ERS-1 imagery

    SciTech Connect (OSTI)

    Payne, J.F. [Bureau of Land Management, Anchorage, AK (United States); Coffeen, M. [Bureau of Land Management, Glennallen, AK (United States); Macleod, R.D. [Ducks Unlimited, Inc., Sacramento, CA (United States)] [and others

    1997-06-01T23:59:59.000Z

    The Bering Glacier is the largest (5,180 km{sup 2}) and longest (191 km) glacier in continental North America. This glacier is one of about 200 temperate glaciers in the Alaska/Canada region that are known to surge. Surges at the Bering Glacier typically occur on a 20-30 year cycle. The objective of this project was to extract information regarding the position of the terminus of the glacier from historic aerial photography, early 20{sup th} century ground photography, Landsat Thematic Mapper (TM) satellite data, and European Space Agency, Synthetic Aperture RADAR (ERS-1 SAR) data and integrate it into a single digital database that would lend itself to change detection analysis. ERS-1 SAR data was acquired from six dates between 1992-95 and was terrain corrected and co-registered A single Landsat TM image from June 1991 was used as the base image for classifying land cover types. Historic locations of the glacier terminus were generated using traditional photo interpretation techniques from aerial and ground photography. The result of this platform combination, along with the historical data, is providing land managers with the unique opportunity to generate complete assessments of glacial movement this century and determine land cover changes which may impact wildlife and recreational opportunities.

  12. High-power, hybrid Er:fiber/Tm:fiber frequency comb source in the 2 {\\mu}m wavelength region

    E-Print Network [OSTI]

    Adler, Florian

    2012-01-01T23:59:59.000Z

    We present a 2-\\mum frequency comb based on a reliable mode-locked Er:fiber laser with 100 MHz repetition rate. After shifting the spectrum of the amplified Er:fiber comb to longer wavelengths, a single-clad Tm/Ho:fiber is used as a self-pumped pre-amplifier to generate a coherent and broadband spectrum centered at 1.93 \\mum. Subsequently, a cladding-pumped Tm:fiber amplifier boosts the system to a maximum output power of 4.8 W at 1.96 \\mum. After compression in a compact grating compressor, our amplified Er:fiber/Tm:fiber hybrid system delivers as much as 2.9 W with a pulse duration of 141 fs. The system's comb properties are examined via heterodyne measurement.

  13. Ethanol Consumption by Rat Dams During Gestation,

    E-Print Network [OSTI]

    Galef Jr., Bennett G.

    Ethanol Consumption by Rat Dams During Gestation, Lactation and Weaning Increases Ethanol examined effects of ethanol consumption in rat dams during gestation, lactation, and weaning on voluntary ethanol consumption by their adolescent young. We found that exposure to an ethanol-ingesting dam

  14. Investigation of the use of an Er:YAG laser and a fluoride glass fiber for laser angioplasty

    E-Print Network [OSTI]

    Kwark, Bongsin

    1989-01-01T23:59:59.000Z

    INVESTIGATION OF THE USE OF AN ER:YAG LASER AND A FLUORIDE ClLASS FIBER FOR LASER ANGIOPLASTY A Thes&s BONC'SIN KA'ARK Submitted to the Office of Clraduate Sturlies of Texas A&M University in partial fulfillment of the requirements... for the degree of 'tIASTER OF SGIEVCE December Iqg9 Major Subject: Electrical Engineering INVESTIGATION OF THE IJSE OF AN ER:YAG LASER. AND A FLUORIDE GLASS FIBER FOR LASER ANGIOPLASTY A Thesis bi BONGSIN I~AVARI~ Approved as to style and content by: ry...

  15. Calcium-sensing receptor activation contributed to apoptosis stimulates TRPC6 channel in rat neonatal ventricular myocytes

    SciTech Connect (OSTI)

    Sun, Yi-hua [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)] [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China); Li, Yong-quan [Harbin Medical University, Harbin 150086 (China)] [Harbin Medical University, Harbin 150086 (China); Feng, Shan-li [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)] [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China); Li, Bao-xin; Pan, Zhen-wei [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China)] [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China); Xu, Chang-qing [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China)] [Department of Pathophysiology, Harbin Medical University, Harbin 150086 (China); Li, Ting-ting [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China)] [Department of Clinical Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086 (China); Yang, Bao-feng, E-mail: syh200415@yahoo.com.cn [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China)] [Department of Pharmacology, Harbin Medical University, Harbin 150086 (China)

    2010-04-16T23:59:59.000Z

    Capacitative calcium entry (CCE) refers to the influx of calcium through plasma membrane channels activated on depletion of endoplasmic sarcoplasmic/reticulum (ER/SR) Ca{sup 2+} stores, which is performed mainly by the transient receptor potential (TRP) channels. TRP channels are expressed in cardiomyocytes. Calcium-sensing receptor (CaR) is also expressed in rat cardiac tissue and plays an important role in mediating cardiomyocyte apoptosis. However, there are no data regarding the link between CaR and TRP channels in rat heart. In this study, in rat neonatal myocytes, by Ca{sup 2+} imaging, we found that the depletion of ER/SR Ca{sup 2+} stores by thapsigargin (TG) elicited a transient rise in cytoplasmic Ca{sup 2+} ([Ca{sup 2+}]{sub i}), followed by sustained increase depending on extracellular Ca{sup 2+}. But, TRP channels inhibitor (SKF96365), not L-type channels or the Na{sup +}/Ca{sup 2+} exchanger inhibitors, inhibited [Ca{sup 2+}]{sub i} relatively high. Then, we found that the stimulation of CaR with its activator gadolinium chloride (GdCl{sub 3}) or by an increased extracellular Ca{sup 2+}([Ca{sup 2+}]{sub o}) increased the concentration of intracelluar Ca{sup 2+}, whereas, the sustained elevation of [Ca{sup 2+}]{sub i} was reduced in the presence of SKF96365. Similarly, the duration of [Ca{sup 2+}]{sub i} increase was also shortened in the absence of extracellular Ca{sup 2+}. Western blot analysis showed that GdCl{sub 3} increased the expression of TRPC6, which was reversed by SKF96365. Additionally, SKF96365 reduced cardiomyocyte apoptosis induced by GdCl{sub 3}. Our results suggested that CCE exhibited in rat neonatal myocytes and CaR activation induced Ca{sup 2+}-permeable cationic channels TRPCs to gate the CCE, for which TRPC6 was one of the most likely candidates. TRPC6 channel was functionally coupled with CaR to enhance the cardiomyocyte apoptosis.

  16. Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats

    SciTech Connect (OSTI)

    Banu, Sakhila K. [Reproductive Endocrinology and Cell Signaling Laboratory, Texas A and M University, TAMU 4458, College Station, Texas 77843 (United States); Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, TAMU 4458, College Station, Texas 77843 (United States); Interdisciplinary Faculties of Toxicology and Reproductive Biology, Texas A and M University, TAMU 4458, College Station, Texas 77843 (United States)], E-mail: skbanu@cvm.tamu.edu; Samuel, Jawahar B. [Department of Zoology, St. John's College, Palayamkottai, 627 002 (India); Arosh, Joe A. [Reproductive Endocrinology and Cell Signaling Laboratory, Texas A and M University, TAMU 4458, College Station, Texas 77843 (United States); Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, TAMU 4458, College Station, Texas 77843 (United States); Burghardt, Robert C. [Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, TAMU 4458, College Station, Texas 77843 (United States); Interdisciplinary Faculties of Toxicology and Reproductive Biology, Texas A and M University, TAMU 4458, College Station, Texas 77843 (United States); Aruldhas, Michael M. [Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600113 (India)], E-mail: aruldhasmm@yahoo.com

    2008-10-15T23:59:59.000Z

    Hexavalent chromium (Cr-VI) is used in a wide range of industries. Cr-VI from chromate industries and atmospheric emissions contribute to the Cr contamination in the environment. Cr is a reproductive metal toxicant that can traverse the placental barrier and cause a wide range of fetal effects including ovotoxicity. Therefore, the goal of this study was to investigate the basic mechanisms involved in Cr(VI)-induced ovotoxicity, and the protective role of vitamin C on ovarian follicular development and function in Cr(VI)-induced reproductive toxicity using both in vivo and in vitro approaches. Lactating rats received potassium dichromate (200 mg/L) with or without vitamin C (500 mg/L), through drinking water from postpartum days 1-21. During postnatal days (PND) 1-21 the pups received Cr(VI) via the mother's milk. Pups from both control and treatment groups were continued on regular diet and water from PND-21 onwards, and euthanized on PND-21, -45 and -65. Cr(VI) decreased steroidogenesis, GH and PRL, increased FSH and did not alter LH. Cr(VI) delayed puberty, decreased follicle number, and extended estrous cycle. Spontaneously immortalized rat granulosa cells were treated with 12.5 {mu}M (IC{sub 50}) potassium dichromate for 12 and 24 h, with or without vitamin C pre-treatment. Cr(VI) decreased the mRNA expressions of StAR, SF-1, 17{beta}-HSD-1, 17{beta}-HSD-2, FSHR, LHR, ER{alpha} and ER{beta}. Vitamin C pre-treatment protected ovary and granulosa cells from the deleterious effects of Cr(VI) toxicity, both in vivo and in vitro. Therefore, Cr(VI) toxicity could be a potential risk to the reproductive system in developing females, and vitamin C plays a protective role against Cr(VI)-induced ovotoxicity.

  17. IFP --Oil & Gas Science and Technology --(Script : 1er specimen) --1 --Oil & Gas Science and Technology --rev. IFP, Vol. xx (2009), No X, pp. 00-00

    E-Print Network [OSTI]

    Boyer, Edmond

    2009-01-01T23:59:59.000Z

    IFP -- Oil & Gas Science and Technology -- (Script : 1er specimen) -- 1 -- Oil & Gas Science2010 Author manuscript, published in "Oil & Gas Science and Technology - Rev. IFP, 65, 3 (2010) 435-444" DOI : 10.2516/ogst/2010007 #12;IFP -- Oil & Gas Science and Technology -- (Script : 1er specimen) -- 2

  18. Optical Temperature Sensor Using Infrared-to-Visible-Frequency Upconversion in Er This article has been downloaded from IOPscience. Please scroll down to see the full text article.

    E-Print Network [OSTI]

    Cao, Wenwu

    Optical Temperature Sensor Using Infrared-to-Visible-Frequency Upconversion in Er 3+ /Yb 3. 8 (2011) 087804 Optical Temperature Sensor Using Infrared-to-Visible-Frequency Upconversion in Er3 State University, University Park, Pennsylvania 16802, USA (Received 24 May 2011) An optical temperature

  19. Completion Report for Model Evaluation Well ER-11-2: Corrective Action Unit 98: Frenchman Flat

    SciTech Connect (OSTI)

    NSTec Underground Test Area and Boreholes Programs and Operations

    2013-01-22T23:59:59.000Z

    Model Evaluation Well ER-11-2 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of Nevada Environmental Management Operations at the Nevada National Security Site (formerly known as the Nevada Test Site). The well was drilled in August 2012 as part of a model evaluation program in the Frenchman Flat area of Nye County, Nevada. The primary purpose of the well was to provide detailed geologic, hydrogeologic, chemical, and radionuclide data that can be used to test and build confidence in the applicability of the Frenchman Flat Corrective Action Unit flow and transport models for their intended purpose. In particular, this well was designed to provide data to evaluate the uncertainty in model forecasts of contaminant migration from the upgradient underground nuclear test PIN STRIPE, conducted in borehole U-11b in 1966. Well ER-11-2 will provide information that can be used to refine the Phase II Frenchman Flat hydrostratigraphic framework model if necessary, as well as to support future groundwater flow and transport modeling. The main 31.1-centimeter (cm) hole was drilled to a total depth of 399.6 meters (m). A completion casing string was not set in Well ER-11-2. However, a piezometer string was installed in the 31.1-cm open hole. The piezometer is composed of 7.3-cm stainless-steel tubing hung on 6.0-cm carbon-steel tubing via a crossover sub. The piezometer string was landed at 394.5 m, for monitoring the lower tuff confining unit. Data collected during and shortly after hole construction include composite drill cuttings samples collected every 3.0 m, various geophysical logs, water quality (including tritium and other test-related radionuclides) measurements, and water level measurements. The well penetrated 42.7 m of Quaternary and Tertiary alluvium and 356.9 m of Tertiary volcanic rock. The water-level measured in the piezometer string on September 25, 2012, was 353.8 m below ground surface. No tritium above levels detectable by field methods were encountered in this hole. No well development or hydrologic testing was conducted in this well immediately after completion, and future well development, sampling, and hydrologic testing planned for this well will be limited due to the diameter of the piezometer string. The stratigraphy, general lithology, and the water level are as expected, but the section of geology encountered is higher than expected due to faulting. No tritium above the minimum detection limit of the field equipment was detected because the target aquifer (the Topopah Spring aquifer) at Well ER-11-2 is structurally higher than expected and thus unsaturated.

  20. Transformation E.R. Bachmann & P.L. McDowell MV 4202 Page 1 of3

    E-Print Network [OSTI]

    McDowell, Perry

    Transformation E.R. Bachmann & P.L. McDowell MV 4202 Page 1 of3 5. Transformations Overview window coordinates Modeling Transformations Projection Transformation Perspective Division Viewport Transformation Object Coordinates x, y, z, w Modelview Matrix Projection Matrix Eye Coordinates Clip Coordinates

  1. DEPARTMENT OF THE ARMY ER 11-1-321 U.S. Army Corps of Engineers Change 1

    E-Print Network [OSTI]

    US Army Corps of Engineers

    Appendix C Sample Content of VE Plan and Work Breakdown Structure to Appendix C Scheduling Requirements to ER 11-1-321, 28 February 2005, a. Corrects VE study applicability for total project cost from $2M to $1M, Paragraph 2. b. Changes Paragraph 5. Definitions. Glossary inserted in Appendices replaces

  2. Postdoctoral fellowship in ore-deposit geology/igneous geochemistry Marie-Curie Initial Training Network ABYSS (ER1)

    E-Print Network [OSTI]

    Demouchy, Sylvie

    Postdoctoral fellowship in ore-deposit geology/igneous geochemistry Marie-Curie Initial Training Network ABYSS (ER1) Training network on reactive geological systems from the mantle to the abyssal sub-Cu-PGE deposits Requirements: Candidates must hold PhD in geology/geochemistry This fellowship is for a period

  3. 112 IEEE MICROWAVE AND GUIDED WAVE LETI'ERS, VOL. 4, NO. 4, APRIL 1994 Planar Amplifier Array With Improved

    E-Print Network [OSTI]

    York, Robert A.

    -wave applications demanding large output power, with low-noise, high- efficiency, and solid-state reliability the amplifier measurements and device requirements. A simple resistive feedback amplifier was designed, using112 IEEE MICROWAVE AND GUIDED WAVE LETI'ERS, VOL. 4, NO. 4, APRIL 1994 Planar Amplifier Array

  4. Utilisation des archives ERS pour la dtection de mouvements de glaciers rocheux dans les Alpes franaises par interfromtrie

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Utilisation des archives ERS pour la détection de mouvements de glaciers rocheux dans les Alpes semblait pertinente pour détecter le fluage des glaciers rocheux. Dans cette étude nous nous intéressons à la détection des mouvements des glaciers rocheux sur la totalité des Alpes françaises. Pour cela nous

  5. ER 100/200, PP C184/284 GSI Section Notes Energy & Society Section Week 5: Thermodynamics

    E-Print Network [OSTI]

    Kammen, Daniel M.

    . Property Diagrams and Power Cycles V. Additional Material, Terms, and Variables VI. Practice Problems I form to another. As an equation, this is simply: Esystem = 0 = Ein ­ Eout #12;ER 100/200, PP C184 system its change in energy will be the balance between the heat transferred to (Qin) and the work done

  6. Sjaggeren, der hopper rundt i haven og spiser af vinterens udbud af rdne bler, er ankommet fra

    E-Print Network [OSTI]

    Thorup, Kasper

    , rovfugle, ænder, gæs og vadefugle passerer hen over Danmark i træksæso- nerne. Nogle af dem yngler i Danmark, andre er her kun som vintergæster, men langt størstedelen passerer bare igennem landet. Kun en lille andel af de danske arter forbliver hele deres liv inden for Danmarks grænser (Bønløkke et al. i

  7. Final report for DOE-FG02-02ER54688: Study of nonlinear interactions between counterpropagating shear Alfven waves

    SciTech Connect (OSTI)

    Carter, T A

    2006-11-16T23:59:59.000Z

    Final report for DOE Plasma Physics Junior Faculty Development award DOE-FG02-02ER54688. Reports on research undertaken from 8/1/2002 until 5/15/2006, investigating nonlinear interactions between Alfven waves in a laboratory experiment.

  8. MGS MAG/ER observations at the magnetic pileup boundary of Mars: draping enhancement and low frequency waves

    E-Print Network [OSTI]

    California at Berkeley, University of

    MGS MAG/ER observations at the magnetic pileup boundary of Mars: draping enhancement and low Propulsion Laboratory, 4800 Oak Grove Drive, Pasadena, CA 91109, USA Received 26 November 2002; received in revised form 19 March 2003; accepted 24 April 2003 Abstract The magnetic pileup boundary (MPB) is a sharp

  9. Nanocomposites of Semimetallic ErAs Nanoparticles Epitaxially Embedded within InGaAlAs-based Semiconductors for Thermoelectric Materials

    E-Print Network [OSTI]

    GaAlAs-based Semiconductors for Thermoelectric Materials J.M.O. Zide', G. Zeng2, J.H. Bahk2, W. Kim3, S. L. Singer3, DAs nanoparticles which are epitaxially embedded within InGaAlAs-based semiconductors. The properties. In one geometry, barriers of InGaAlAs, a wider bandgap semiconductor, are introduced into an Er

  10. ISodotY of PetroIeumEr@nwrsI Petroleum Reservoir Simulation in a Virtual Environment

    E-Print Network [OSTI]

    a'4P w ._ m I I ISodotY of PetroIeumEr@nwrsI SPE 29118 Petroleum Reservoir Simulation in a VirtualSPE Member TM paperwas preperedfor presentationat the 13fh SPE Sym~ium on ReservoirSimulationheld in San, 1S2245SPEUT. ABSTRACT In this paper, we describe an approach to combining a reservoir simulation

  11. Octave-spanning supercontinuum generation for an er-doped fiber laser frequency comb at a 1 ghz repetition rate

    E-Print Network [OSTI]

    Chao, David

    We developed a 1 GHz Er-doped femtosecond fiber laser system providing 2nJ pulses at [equivalence relation symbol]100fs durations and demonstrated octave-spanning supercontinuum generation from 1µm - 2.4µm that is suitable ...

  12. TOWARDS AN ER-DOPED SI NANOCRYSTAL SENSITIZED WAVEGUIDE LASER THE THIN LINE BETWEEN GAIN AND LOSS

    E-Print Network [OSTI]

    Kik, Pieter

    and waveguide. If the pump laser could somehow be eliminated from this scheme, the fabrication of low-cost SiTOWARDS AN ER-DOPED SI NANOCRYSTAL SENSITIZED WAVEGUIDE LASER ­ THE THIN LINE BETWEEN GAIN AND LOSS-doped SiO2, a composite material that can potentially be fabricated using a VLSI compatible process

  13. Dichlorodiphenyltrichloroethane technical mixture regulates cell cycle and apoptosis genes through the activation of CAR and ER? in mouse livers

    SciTech Connect (OSTI)

    Kazantseva, Yuliya A.; Yarushkin, Andrei A. [Institute of Molecular Biology and Biophysics SB RAMS, Novosibirsk, Timakova str., 2, 630117 (Russian Federation); Pustylnyak, Vladimir O., E-mail: pustylnyak@ngs.ru [Institute of Molecular Biology and Biophysics SB RAMS, Novosibirsk, Timakova str., 2, 630117 (Russian Federation); Novosibirsk State University, Novosibirsk, Pirogova str., 2, 630090 (Russian Federation)

    2013-09-01T23:59:59.000Z

    Dichlorodiphenyltrichloroethane (DDT) is a widely used organochlorine pesticide and a xenoestrogen that promotes rodent hepatomegaly and tumours. A recent study has shown significant correlation between DDT serum concentration and liver cancer incidence in humans, but the underlying mechanisms remain elusive. We hypothesised that a mixture of DDT isomers could exert effects on the liver through pathways instead of classical ERs. The acute effects of a DDT mixture containing the two major isomers p,p?-DDT (85%) and o,p?-DDT (15%) on CAR and ER? receptors and their cell cycle and apoptosis target genes were studied in mouse livers. ChIP results demonstrated increased CAR and ER? recruitment to their specific target gene binding sites in response to the DDT mixture. The results of real-time RT-PCR were consistent with the ChIP data and demonstrated that the DDT was able to activate both CAR and ER? in mouse livers, leading to target gene transcriptional increases including Cyp2b10, Gadd45?, cMyc, Mdm2, Ccnd1, cFos and E2f1. Western blot analysis demonstrated increases in cell cycle progression proteins cMyc, Cyclin D1, CDK4 and E2f1 and anti-apoptosis proteins Mdm2 and Gadd45?. In addition, DDT exposure led to Rb phosphorylation. Increases in cell cycle progression and anti-apoptosis proteins were accompanied by a decrease in p53 content and its transcriptional activity. However, the DDT was unable to stimulate the ?-catenin signalling pathway, which can play an important role in hepatocyte proliferation. Thus, our results indicate that DDT treatment may result in cell cycle progression and apoptosis inhibition through CAR- and ER?-mediated gene activation in mouse livers. These findings suggest that the proliferative and anti-apoptotic conditions induced by CAR and ER? activation may be important contributors to the early stages of hepatocarcinogenesis as produced by DDT in rodent livers. - Highlights: • DDT activated both CAR and ER? and their cell cycle and apoptosis target genes. • DDT produced increases in cell cycle and anti-apoptosis proteins and decrease in p53. • DDT mixture was unable to stimulate the ?-catenin signalling pathway in mouse livers.

  14. The crystal structure of {pi}-ErBO{sub 3}: New single-crystal data for an old problem

    SciTech Connect (OSTI)

    Pitscheider, Almut [Institut fuer Allgemeine, Anorganische und Theoretische Chemie, Leopold-Franzens-Universitaet Innsbruck, Innrain 52a, A-6020 Innsbruck (Austria); Kaindl, Reinhard [Institut fuer Mineralogie und Petrographie, Leopold-Franzens-Universitaet Innsbruck, Innrain 52, A-6020 Innsbruck (Austria); Oeckler, Oliver [Department Chemie, Ludwig-Maximilians-Universitaet Muenchen, Butenandtstrasse 5-13, D-81377 Muenchen (Germany); Huppertz, Hubert, E-mail: Hubert.Huppertz@uibk.ac.a [Institut fuer Allgemeine, Anorganische und Theoretische Chemie, Leopold-Franzens-Universitaet Innsbruck, Innrain 52a, A-6020 Innsbruck (Austria)

    2011-01-15T23:59:59.000Z

    Single crystals of the orthoborate {pi}-ErBO{sub 3} were synthesized from Er{sub 2}O{sub 3} and B{sub 2}O{sub 3} under high-pressure/high-temperature conditions of 2 GPa and 800 {sup o}C in a Walker-type multianvil apparatus. The crystal structure was determined on the basis of single-crystal X-ray diffraction data, collected at room temperature. The title compound crystallizes in the monoclinic pseudowollastonite-type structure, space group C2/c, with the lattice parameters a=1128.4(2) pm, b=652.6(2) pm, c=954.0(2) pm, and {beta}=112.8(1){sup o} (R{sub 1}=0.0124 and wR{sub 2}=0.0404 for all data). -- graphical abstract: The first satisfying single-crystal structure determination of {pi}-ErBO{sub 3} sheds light on the extensively discussed structure of {pi}-orthoborates. The application of light pressure during the solid state synthesis yielded in high-quality crystals, due to pressure-induced crystallization. Research highlights: {yields} High-quality single crystals of {pi}-ErBO{sub 3} were prepared via high-pressure-induced crystallization. {yields} At least five different space groups for the rare-earth {pi}-orthoborates are reported. {yields} {pi}-ErBO{sub 3} is isotypic to the pseudowollastonite-type CaSiO{sub 3}. {yields} Remaining ambiguities regarding the structure of the rare-earth {pi}-orthoborates are resolved.

  15. Arginine metabolism in enterocytes of diabetic rats

    E-Print Network [OSTI]

    Morrow, Natalie Anne

    2002-01-01T23:59:59.000Z

    Diabetic rats and patients exhibit decreased plasma arginine concentrations. Arginine is important in numerous cellular pathways, including the synthesis of nitric oxide and the release of insulin from pancreatic ? cells. At present, little...

  16. Purification of sulfide oxidase from rat liver

    E-Print Network [OSTI]

    Pu, Lixia

    1994-01-01T23:59:59.000Z

    The present study represents an initial investigative effort to purify sulfide oxidase from rat liver. Two methods to determine sulfide oxidase activity have been established and both are based on measuring substrate disappearance of sulfide. Both...

  17. THE BEHAVIOR OF THE LABORATORY RAT

    E-Print Network [OSTI]

    Galef Jr., Bennett G.

    , Alaska, at 60 degrees North latitude, where rats feed on human garbage, to South Georgia Island, at 55 members that had survived their ini- tial contact with the poisoned bait and had learned to avoid eating

  18. The protein pheromone Er-1 of the ciliate Euplotes raikovi stimulates human T-cell activity: Involvement of interleukin-2 system

    SciTech Connect (OSTI)

    Cervia, Davide, E-mail: d.cervia@unitus.it [Department for Innovation in Biological, Agro-food and Forest systems (DIBAF), University of Tuscia, Viterbo (Italy) [Department for Innovation in Biological, Agro-food and Forest systems (DIBAF), University of Tuscia, Viterbo (Italy); Department of Biomedical and Clinical Sciences, “Luigi Sacco” University Hospital, University of Milan, Milano (Italy); Catalani, Elisabetta; Belardinelli, Maria Cristina [Department for Innovation in Biological, Agro-food and Forest systems (DIBAF), University of Tuscia, Viterbo (Italy)] [Department for Innovation in Biological, Agro-food and Forest systems (DIBAF), University of Tuscia, Viterbo (Italy); Perrotta, Cristiana [Department of Biomedical and Clinical Sciences, “Luigi Sacco” University Hospital, University of Milan, Milano (Italy)] [Department of Biomedical and Clinical Sciences, “Luigi Sacco” University Hospital, University of Milan, Milano (Italy); Picchietti, Simona [Department for Innovation in Biological, Agro-food and Forest systems (DIBAF), University of Tuscia, Viterbo (Italy)] [Department for Innovation in Biological, Agro-food and Forest systems (DIBAF), University of Tuscia, Viterbo (Italy); Alimenti, Claudio [Department of Environmental and Natural Sciences, University of Camerino, Camerino (Italy)] [Department of Environmental and Natural Sciences, University of Camerino, Camerino (Italy); Casini, Giovanni; Fausto, Anna Maria [Department for Innovation in Biological, Agro-food and Forest systems (DIBAF), University of Tuscia, Viterbo (Italy)] [Department for Innovation in Biological, Agro-food and Forest systems (DIBAF), University of Tuscia, Viterbo (Italy); Vallesi, Adriana [Department of Environmental and Natural Sciences, University of Camerino, Camerino (Italy)] [Department of Environmental and Natural Sciences, University of Camerino, Camerino (Italy)

    2013-02-01T23:59:59.000Z

    Water-soluble protein signals (pheromones) of the ciliate Euplotes have been supposed to be functional precursors of growth factors and cytokines that regulate cell–cell interaction in multi-cellular eukaryotes. This work provides evidence that native preparations of the Euplotes raikovi pheromone Er-1 (a helical protein of 40 amino acids) specifically increases viability, DNA synthesis, proliferation, and the production of interferon-?, tumor necrosis factor-?, interleukin (IL)-1?, IL-2, and IL-13 in human Jurkat T-cells. Also, Er-1 significantly decreases the mRNA levels of the ? and ? subunits of IL-2 receptor (IL-2R), while the mRNA levels of the ? subunit appeared to be not affected. Jurkat T-cell treatments with Er-1 induced the down-regulation of the IL-2R? subunit by a reversible and time-dependent endocytosis, and increased the levels of phosphorylation of the extracellular signal-regulated kinases (ERK). The cell-type specificity of these effects was supported by the finding that Er-1, although unable to directly influence the growth of human glioma U-373 cells, induced Jurkat cells to synthesize and release factors that, in turn, inhibited the U-373 cell proliferation. Overall, these findings imply that Er-1 coupling to IL-2R and ERK immuno-enhances T-cell activity, and that this effect likely translates to an inhibition of glioma cell growth. -- Highlights: ? Euplotes pheromone Er-1 increases the growth of human Jurkat T-cells. ? Er-1 increases the T-cell production of specific cytokines. ? Er-1 activates interleukin-2 receptor and extracellular signal-regulated kinases. ? The immuno-enhancing effect of Er-1 on Jurkat cells translates to an inhibition of human glioma cell growth.

  19. Inland EmpIrE mErchandIsE Exports calIfornIa statE UnIvErsIty fUllErton

    E-Print Network [OSTI]

    de Lijser, Peter

    Inland EmpIrE mErchandIsE Exports calIfornIa statE UnIvErsIty fUllErton 20122012 CSUF Mihaylo University, Fullerton An Overview and Analysis of Inland Empire Exports #12;novEmbEr 2011 InstItUtE for EconomIc and EnvIronmEntal stUdIEs33 #12;Inland EmpIrE mErchandIsE Exports calIfornIa statE UnIvErsIty f

  20. Analysis of Well ER-6-2 Testing, Yucca Flat FY 2004 Testing Program, Nevada Test Site, Nye County, Nevada, Rev. No.: 0

    SciTech Connect (OSTI)

    Greg Ruskauff

    2005-07-01T23:59:59.000Z

    This report documents the analysis of data collected for Well ER-6-2 during fiscal year (FY) 2004 Yucca Flat well development and testing program (herein referred to as the ''testing program''). Participants in Well ER-6-2 field development and hydraulic testing activities were: Stoller-Navarro Joint Venture (SNJV), Bechtel Nevada (BN), Desert Research Institute (DRI), Los Alamos National Laboratory (LANL), Lawrence Livermore National Laboratory (LLNL), U.S. Geological Survey (USGS), and the University of Nevada, Las Vegas-Harry Reid Center (UNLV-HRC). The analyses of data collected from the Well ER-6-2 testing program were performed by the SNJV.

  1. Helium release and microstructural changes in Er(D,T)2-x3Hex films).

    SciTech Connect (OSTI)

    Gelles, D. S. (Pacific Northwest National Laboratory, Richland, WA); Browning, James Frederick; Snow, Clark Sheldon; Banks, James Clifford; Mangan, Michael A.; Rodriguez, Mark Andrew; Brewer, Luke N.; Kotula, Paul Gabriel

    2007-12-01T23:59:59.000Z

    Er(D,T){sub 2-x} {sup 3}He{sub x}, erbium di-tritide, films of thicknesses 500 nm, 400 nm, 300 nm, 200 nm, and 100 nm were grown and analyzed by Transmission Electron Microscopy, X-Ray Diffraction, and Ion Beam Analysis to determine variations in film microstructure as a function of film thickness and age, due to the time-dependent build-up of {sup 3}He in the film from the radioactive decay of tritium. Several interesting features were observed: One, the amount of helium released as a function of film thickness is relatively constant. This suggests that the helium is being released only from the near surface region and that the helium is not diffusing to the surface from the bulk of the film. Two, lenticular helium bubbles are observed as a result of the radioactive decay of tritium into {sup 3}He. These bubbles grow along the [111] crystallographic direction. Three, a helium bubble free zone, or 'denuded zone' is observed near the surface. The size of this region is independent of film thickness. Four, an analysis of secondary diffraction spots in the Transmission Electron Microscopy study indicate that small erbium oxide precipitates, 5-10 nm in size, exist throughout the film. Further, all of the films had large erbium oxide inclusions, in many cases these inclusions span the depth of the film.

  2. Letter Report: Borehole Flow and Horizontal Hydraulic Conductivity with Depth at Well ER-12-3

    SciTech Connect (OSTI)

    P. Oberlander; C. Russell

    2005-09-01T23:59:59.000Z

    Borehole flow and fluid temperature during pumping were measured at well ER-12-3 at the Nevada Test Site in Nye County, Nevada. This well was constructed to characterize the carbonate aquifer. The well is cased from land surface to the total depth at 1,487 m (4,880 ft) below ground surface (bgs). Slotted screen is placed in an upper screened section from 1,095 to 1,160 m bgs (3,591 to 3,805 ft bgs) and in the lower screened section from 1,278 to 1,474 m bgs (4,191 to 4,834 ft bgs). Borehole flow velocity (LT-1) with depth was measured with an impeller flowmeter from the top of the screened section to the maximum accessible depth while the well was pumped and under ambient conditions. A complicating factor to data interpretation is that the well was not filter packed and there is significant upward and downward vertical flow in the open annulus under ambient and pumping conditions. The open annulus and large vertical flow velocities in the well casing result in the measured borehole flow rates being potentially highly nonrepresentative of conditions in the aquifer. Hydraulic conductivities calculated under these conditions would require unsupportable assumptions and would be subject to very large uncertainties. Borehole hydraulic conductivities are not presented under these conditions.

  3. Letter Report: Borehole Flow and Horizontal Hydraulic Conductivity with Depth at Well ER-12-4

    SciTech Connect (OSTI)

    Phil L. Oberlander; Charles E. Russell

    2005-12-31T23:59:59.000Z

    Borehole flow and fluid temperature during pumping were measured at well ER-12-4 at the Nevada Test Site in Nye County, Nevada. This well was constructed to characterize the carbonate aquifer. The well is cased from land surface to the total depth at 1,132 m (3,713 ft bgs) below ground surface (bgs). The screened section of the well consists of alternating sections of slotted well screen and blank casing from 948 to 1,132 m bgs (3,111 to 3,713 ft bgs). Borehole flow velocity (LT-1) with depth was measured with an impeller flowmeter from the top of the screened section to the maximum accessible depth while the well was pumped and under ambient conditions. A complicating factor to data interpretation is that the well was not filter packed and there is upward and downward vertical flow in the open annulus under ambient and pumping conditions. The open annulus in the well casing likely causes the calculated borehole flow rates being highly nonrepresentative of inflow from the formation. Hydraulic conductivities calculated under these conditions would require unsupportable assumptions and would be subject to very large uncertainties. Borehole hydraulic conductivities are not presented under these conditions.

  4. Final Technical Report for Award DE-FG02-98ER41080

    SciTech Connect (OSTI)

    Chen, Alan

    2014-11-14T23:59:59.000Z

    The prime motivation of the project at McMaster University was to carry out the critical evaluation and compilation of Nuclear Structure and Decay data, and of nuclear astrophysics data with continued participation in the United States Nuclear Data Program (US-NDP). A large body of evaluated and compiled structure data were supplied for databases such as ENSDF, XUNDL, NSR, etc. residing on webpage of National Nuclear Data Center of the Brookhaven National Laboratory, Upton, New York, USA. Thermonuclear reaction rates of importance to stellar explosions, such as novae, x-ray bursts and supernovae, were evaluated as well. This effort was closely coupled to our ongoing experimental effort, which took advantage of radioactive ion beam and stable beam facilities worldwide to study these key reaction rates. This report contains brief descriptions of the various activities together with references to all the publications in peer-reviewed journals which were the result of work carried out with the award DE-FG02-98-ER41080, during 1998-2013.

  5. Completion Report for the Well ER-6-2 Site Corrective Action Unit 97: Yucca Flat - Climax Mine

    SciTech Connect (OSTI)

    NSTec Environmental Management

    2008-03-01T23:59:59.000Z

    Well ER-6-2 and its satellite hole, Well ER-6-2 No.1, were drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. Well ER-6-2 was drilled in two stages in 1993 and 1994; the satellite hole, Well ER-6-2 No.1 was drilled nearby in 1993 but was abandoned. The wells were drilled as part of a hydrogeologic investigation program for the Yucca Flat-Climax Mine Corrective Action Unit Number 97, in the northeastern portion of the Nevada Test Site. The wells are located in Yucca Flat, within Area 6 of the Nevada Test Site. The wells provided information regarding the radiological and hydrogeological environment in a potentially down-gradient position from tests conducted in northern and central Yucca Flat. Construction of Well ER-6-2 began with a 1.2-meter-diameter surface conductor hole, which was drilled and cased off to a depth of 30.8 meters below the surface. A 50.8-centimeter diameter surface hole was then rotary drilled to the depth of 578.5 meters and cased off to the depth of 530.4 meters. The hole diameter was then reduced to 27.0 centimeters, and the borehole was advanced to a temporary depth of 611.4 meters. The borehole was conventionally cored to a total depth of 1,045 meters with a diameter of 14.0 centimeters. Borehole sloughing required cementing and re-drilling of several zones. The open-hole completion accesses the lower carbonate aquifer, the CP thrust fault, and the upper clastic confining unit. A fluid level depth of 543.2 meters was most recently measured in the open borehole in September 2007. No radionuclides were encountered during drilling. The satellite hole Well ER-6-2 No.1 was drilled approximately 15.2 meters north of Well ER-6-2 on the same drill pad. This was planned to be used as an observation well during future hydrologic testing at Well ER-6-2; however, the satellite hole was abandoned at the depth of 399 meters due to stuck drill pipe, and was subsequently cemented to the surface. Detailed lithologic descriptions with stratigraphic assignments in this report are based on composite drill cuttings samples collected every 3 meters, cores taken between the depths of 619.3 and 1,042.4 meters, and geophysical log data. Stratigraphic assignments within the Paleozoic section are based on paleontological analyses. The well was collared in alluvium and at 30.8 meters penetrated Paleozoic carbonate rocks. These consisted of dolostone with minor shale and limestone of the Bonanza King Formation, and limestone with minor quartzite, sandstone, and dolostone assigned to the Guilmette Formation. The borehole reached total depth in a shale unit assigned to the Chainman Shale. The units below the Bonanza King Formation are overturned due to faulting and folding and, therefore, are stratigraphically upside-down.

  6. Silver nanoparticles enhanced luminescence properties of Er{sup 3+} doped tellurite glasses: Effect of heat treatment

    SciTech Connect (OSTI)

    Fares, Hssen; Férid, Mokhtar [Laboratoire de Physico-Chimie des Matériaux Minéraux et leurs Applications, Centre National de Recherches en Sciences des Matériaux, B.P. 95 Hammam-Lif, 2050 (Tunisia); Elhouichet, Habib, E-mail: habib.elhouichet@fst.rnu.tn [Laboratoire de Physico-Chimie des Matériaux Minéraux et leurs Applications, Centre National de Recherches en Sciences des Matériaux, B.P. 95 Hammam-Lif, 2050 (Tunisia); Department of Physics, Sciences Faculty of Tunis, University Tunis ElManar 2092 (Tunisia); Gelloz, Bernard [Graduate School of Engineering, Nagoya University, 2-24-16 Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8603 (Japan)

    2014-09-28T23:59:59.000Z

    Tellurite glasses doped Er{sup 3+} ions and containing Silver nanoparticles (Ag NPs) are prepared using melt quenching technique. The nucleation and growth of Ag NPs were controlled by a thermal annealing process. The X-ray diffraction pattern shows no sharp peak indicating an amorphous nature of the glasses. The presence of Ag NPs is confirmed from transmission electron microscopy micrograph. Absorption spectra show typical surface plasmon resonance (SPR) band of Ag NPs within the 510–550?nm range in addition to the distinctive absorption peaks of Er{sup 3+} ions. The Judd-Ofelt (J-O) intensity parameters, oscillator strengths, spontaneous transition probabilities, branching ratios, and radiative lifetimes were successfully calculated based on the experimental absorption spectrum and the J-O theory. It was found that the presence of silver NPs nucleated and grown during the heat annealing process improves both of the photoluminescence (PL) intensity and the PL lifetime relative to the {sup 4}I{sub 13/2}???{sup 4}I{sub 15/2} transition. Optimum PL enhancement was obtained after 10?h of heat-treatment. Such enhancements are mainly attributed to the strong local electric field induced by SPR of silver NPs and also to energy transfer from the surface of silver NPs to Er{sup 3+} ions, whereas the quenching is ascribed to the energy transfer from Er{sup 3+} ions to silver NPs. Using the Mc Cumber method, absorption cross-section, calculated emission cross-section, and gain cross-section for the {sup 4}I{sub 13/2} ? {sup 4}I{sub 15/2} transition were determined and compared for the doped and co-doped glasses. The present results indicate that the glass heat-treated for 10?h has good prospect as a gain medium applied for 1.53??m band broad and high-gain erbium-doped fiber amplifiers.

  7. Gain dynamics in a soft X-ray laser ampli er perturbed by a strong injected X-ray eld

    SciTech Connect (OSTI)

    Wang, Yong [Colorado State University, Fort Collins] [Colorado State University, Fort Collins; Wang, Shoujun [Colorado State University, Fort Collins] [Colorado State University, Fort Collins; Oliva, E [Laboratoire de Physique des Gaz et des Gaz et des Plasmas] [Laboratoire de Physique des Gaz et des Gaz et des Plasmas; Lu, L [Laboratoire de Physique des Gaz et des Gaz et des Plasmas] [Laboratoire de Physique des Gaz et des Gaz et des Plasmas; Berrill, Mark A [ORNL] [ORNL; Yin, Liang [Colorado State University, Fort Collins] [Colorado State University, Fort Collins; Nejdl, J [Colorado State University, Fort Collins] [Colorado State University, Fort Collins; Luther, Brad [Colorado State University, Fort Collins] [Colorado State University, Fort Collins; Proux, C [Laboratoire d’Optique Applique´e, ENSTA, CNRS, Ecole Polytechnique] [Laboratoire d’Optique Applique´e, ENSTA, CNRS, Ecole Polytechnique; Le, T. T. [Laboratoire de Physique des Gaz et des Gaz et des Plasmas] [Laboratoire de Physique des Gaz et des Gaz et des Plasmas; Dunn, James [Lawrence Livermore National Laboratory (LLNL)] [Lawrence Livermore National Laboratory (LLNL); Ros, D [Laboratoire de Physique des Gaz et des Gaz et des Plasmas] [Laboratoire de Physique des Gaz et des Gaz et des Plasmas; Zeitoun, Philippe [École Polytechnique] [École Polytechnique; Rocca, Jorge [Colorado State University, Fort Collins] [Colorado State University, Fort Collins

    2014-01-01T23:59:59.000Z

    Seeding soft X-ray plasma ampli ers with high harmonics has been demonstrated to generate high-brightness soft X-ray laser pulses with full spatial and temporal coherence. The interaction between the injected coherent eld and the swept-gain medium has been modelled. However, no exper- iment has been conducted to probe the gain dynamics when perturbed by a strong external seed eld. Here, we report the rst X-ray pump X-ray probe measurement of the nonlinear response of a plasma ampli er perturbed by a strong soft X-ray ultra-short pulse. We injected a sequence of two time-delayed high-harmonic pulses (l518.9 nm) into a collisionally excited nickel-like molybdenum plasma to measure with femto-second resolution the gain depletion induced by the saturated ampli cation of the high-harmonic pump and its subsequent recovery. The measured fast gain recovery in 1.5 1.75 ps con rms the possibility to generate ultra-intense, fully phase-coherent soft X-ray lasers by chirped pulse ampli cation in plasma ampli ers.

  8. Spectroscopic properties of Er{sup 3+} doped lead telluroborate glasses for 1.5 ?m broadband amplifiers

    SciTech Connect (OSTI)

    Vijayakumar, R., E-mail: mari-ram2000@yahoo.com; Arunkumar, S., E-mail: mari-ram2000@yahoo.com; Vijayakumar, M., E-mail: mari-ram2000@yahoo.com; Marimuthu, K., E-mail: mari-ram2000@yahoo.com [Department of Physics, Gandhigram Rural Institute ? Deemed University, Gandhigram - 624302 (India)

    2014-04-24T23:59:59.000Z

    Er{sup 3+} doped lead telluroborate glasses (xEPTB) with the composition 25B{sub 2}O{sub 3}-(25-x)TeO{sub 2}-25PbO-10Bi{sub 2}O{sub 3}-15CdO-xEr{sub 2}O{sub 3} (where x=0.1, 0.5, 1 and 2 wt%) have been prepared and characterised using NIR luminescence and decay measurements for 1.5 ?m broadband amplifier applications. Judd-Ofelt intensity parameters have been derived to predict radiative properties of the {sup 4}I{sub 13/2}?{sup 4}I{sub 15/2} emission transition. The larger values of stimulated emission cross-section (?P), FWHM, gain bandwidth (?G), radiative lifetime (?{sup cal}), quantum efficiency (?) of the 1EPTB glass suggest their potential use in broadband amplifiers. The effect of RE ion concentration and OH{sup ?} content on the lifetime of {sup 4}I{sub 13/2}?{sup 4}I{sub 15/2} transition and the energy transfer mechanism of Er{sup 3+} ions have also been discussed and reported in the present study.

  9. Optical absorption and fluorescence properties of Er{sup 3+}/Yb{sup 3+} codoped lead bismuth alumina borate glasses

    SciTech Connect (OSTI)

    Goud, K. Krishna Murthy, E-mail: krishnamurthy.phy@gmail.com; Reddy, M. Chandra Shekhar, E-mail: krishnamurthy.phy@gmail.com; Rao, B. Appa, E-mail: krishnamurthy.phy@gmail.com [Dept. of Physics, Osmania University, Hyderabad-500007, Andhra Pradesh (India)

    2014-04-24T23:59:59.000Z

    Lead bismuth alumina borate glasses codoped with Er{sup 3+}/Yb{sup 3+} were prepared by melt quenching technique. Optical absorption, FTIR and photoluminescence spectra of these glasses have been studied. Judd-Ofelt theory has been applied to to the f ? f transitions for evaluating ?{sub 2}, ?{sub 4} and ?{sub 6} parameters. Radiative properties like branching ratio ?{sub r} and the radiative life time ?{sub R} have been determined on the basis of Judd-Ofelt theory. Upconversion emissions have been observed under 980nm laser excitation at room temperature. Green and red up-conversion emissions are centered at 530, 550 and 656 nm corresponding to {sup 2}H{sub 11/2}?{sup 4}I{sub 15/2}, {sup 4}S{sub 3/2}?{sup 4}I{sub 15/2} and {sup 4}F{sub 9/2}?{sup 4}I{sub 15/2} transitions of Er{sup 3+} respectively. The results obtained are discussed quantitatively based on the energy transfer between Yb{sup 3+} and Er{sup 3+}.

  10. Photoluminescence properties and energy levels of RE (RE?=?Pr, Sm, Er, Tm) in layered-CaZnOS oxysulfide

    SciTech Connect (OSTI)

    Zhang, Zhi-Jun, E-mail: zhangzj@mail.sic.ac.cn [Key Laboratory of Transparent Opto-Functional Inorganic Materials of Chinese Academy of Sciences, Shanghai Institute of Ceramics, Shanghai 200050 (China); Feng, Ang; Chen, Xiang-Yang [Key Laboratory of Transparent Opto-Functional Inorganic Materials of Chinese Academy of Sciences, Shanghai Institute of Ceramics, Shanghai 200050 (China); University of Chinese Academy of Sciences, Beijing 100039 (China); Zhao, Jing-Tai, E-mail: jtzhao@mail.sic.ac.cn [Key Laboratory of Transparent Opto-Functional Inorganic Materials of Chinese Academy of Sciences, Shanghai Institute of Ceramics, Shanghai 200050 (China); School of Materials Science and Engineering, Shanghai University, Shanghai 200072 (China)

    2013-12-07T23:59:59.000Z

    RE{sup 3+} (RE?=?Pr, Sm, Er, Tm)-activated CaZnOS samples were prepared by a solid-state reaction method at high temperature, and their photoluminescence properties were investigated. Doping with RE{sup 3+} (RE?=?Pr, Sm, Er, Tm) into layered-CaZnOS resulted in typical RE{sup 3+} (RE?=?Pr, Sm, Er, Tm) f-f line absorptions and emissions, as well as the charge transfer band of Sm{sup 3+} at about 3.3?eV. The energy level scheme containing the position of the 4f and 5d levels of all divalent and trivalent lanthanide ions with respect to the valence and conduction bands of CaZnOS has been constructed based on the new data presented in this work, together with the data from literature on Ce{sup 3+} and Eu{sup 2+} doping in CaZnOS. The detailed energy level scheme provides a platform for interpreting the optical spectra and could be used to comment on the valence stability of the lanthanide ions in CaZnOS.

  11. Cardiopulmonary Function in RatsWith Lung Hemorrhage

    E-Print Network [OSTI]

    Illinois at Urbana-Champaign, University of

    Cardiopulmonary Function in RatsWith Lung Hemorrhage Induced by Pulsed Ultrasound Exposure Jeffery using superthreshold exposure conditions known to produce sig- nificant lung hemorrhage. Methods. In 1 in the left lung of each rat. In a second group of 6 rats, 5 foci of ultrasound-induced hemorrhage were

  12. Interaction of Ce{sub 1?x}Er{sub x}O{sub 2?y} nanoparticles with SiO{sub 2}-effect of temperature and atmosphere

    SciTech Connect (OSTI)

    Kepinski, L., E-mail: L.Kepinski@int.pan.wroc.pl; Krajczyk, L.; Mista, W.

    2014-01-15T23:59:59.000Z

    Morphology, microstructure and phase evolution of homogeneous, nanocrystalline Ce{sub 1?x}Er{sub x}O{sub 2?x/2} mixed oxide (x=0.3 and 0.5), prepared by microemulsion method, supported on amorphous SiO{sub 2} was studied in oxidizing and reducing atmosphere by XRD, TEM, SEM-EDS and N{sub 2} adsorption. The system is structurally and chemically stable in the oxidizing atmosphere up to 1000 °C, exhibiting only a small increase of the mean crystallite size of the oxide to ?4 nm. At 1100 °C formation of Er silicate with unusual structure isomorphic with y-Y{sub 2}Si{sub 2}O{sub 7} (yttrialite), stabilized by Ce{sup 4+} ions was observed. In the reducing atmosphere the Ce{sub 1?x}Er{sub x}O{sub 2?x/2} reacted with SiO{sub 2} already at 900 °C, due to high affinity of the reduced Ce{sup 3+} to form a silicate phase. At higher temperature the silicate crystallized into the tetragonal, low temperature A-(Ce{sub 1?x}Er{sub x}){sub 2}Si{sub 2}O{sub 7} polymorph. Such systems, containing nanocrystalline silicate particles with Er{sup 3+} ions placed in well defined sites embedded in silica matrix, may be interesting as highly efficient active components of optical waveguides amplifiers integrated with Si microelectronics. The nanocrystalline Ce–Er–O/SiO{sub 2} system prepared by the impregnation of the silica with the aqueous solution of nitrates appeared to be chemically inhomogeneous and less stable in both oxidising and reducing atmosphere. - Graphical abstract: Structure evolution of Ce{sub 0.5}Er{sub 0.5}O{sub 1.75} in air and in H{sub 2}. Display Omitted - Highlights: • Homogeneous 3 nm Ce{sub 1?x}Er{sub x}O{sub 2?y} particles were prepared and uniformly dispersed on SiO{sub 2}. • Er diffusion to SiO{sub 2} determines the stability of the mixed oxide in air to ?1000 °C. • Spreading of Ce{sub 1?x}Er{sub x}O{sub 2?y} onto SiO{sub 2} occurs in hydrogen at 900 °C. • Nanocrystalline A-(Ce,Er){sub 2}Si{sub 2}O{sub 7} silicate forms in H{sub 2} at 1100 °C.

  13. Final Report for DOE Grant DE-FG02-06ER64160 Retrieval of Cloud Properties and Direct Testing of Cloud and Radiation Parameterizations using ARM Observations.

    SciTech Connect (OSTI)

    Donovan, David Patrick [KNMI

    2013-07-26T23:59:59.000Z

    This report briefly summaries the work performed at KNMI under DOE Grant DE-FG02-06ER64160 which, in turn was conducted in support of DOE Grant DE-FG02-90ER61071 lead by E. Clothieux of Penn. State U. The specific work at KNMI revolved around the development and application of the EarthCARE simulator to ground-based multi-sensor simulations.

  14. Role of estrogen receptor alpha (ER alpha) insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells

    E-Print Network [OSTI]

    Zhang, Shu

    2009-05-15T23:59:59.000Z

    ROLE OF ESTROGEN RECEPTOR ? (ER?) IN INSULIN-LIKE GROWTH FACTOR (IGF)-I-INDUCED RESPONSES IN MCF-7 BREAST CANCER CELLS A Dissertation by SHU ZHANG Submitted to the Office of Graduate Studies of Texas A&M University in partial... fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY December 2007 Major Subject: Toxicology ROLE OF ESTROGEN RECEPTOR ? (ER?) IN INSULIN-LIKE GROWTH FACTOR (IGF)-I-INDUCED RESPONSES IN MCF-7 BREAST CANCER CELLS A Dissertation...

  15. WBS-FOR CREATING AN ER-MODEL Let A(Ei) = the set of attributes of entity-set an Ei.

    E-Print Network [OSTI]

    Kundu, Sukhamay

    WBS-FOR CREATING AN ER-MODEL · Let A(Ei) = the set of attributes of entity-set an Ei. · Let A from each Ei partici- pating in Rj, can interact multiple times, then we need a pri- mary key among FOR CREATING ER-MODELS Identify name and A(Ei) for each Ei Identify a primary key for each Ei Identify name

  16. Completion Report for Model Evaluation Well ER-5-5: Corrective Action Unit 98: Frenchman Flat

    SciTech Connect (OSTI)

    NSTec Underground Test Area and Boreholes Programs and Operations

    2013-01-18T23:59:59.000Z

    Model Evaluation Well ER-5-5 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of Nevada Environmental Management Operations at the Nevada National Security Site (formerly known as the Nevada Test Site). The well was drilled in July and August 2012 as part of a model evaluation well program in the Frenchman Flat area of Nye County, Nevada. The primary purpose of the well was to provide detailed geologic, hydrogeologic, chemical, and radiological data that can be used to test and build confidence in the applicability of the Frenchman Flat Corrective Action Unit flow and transport models for their intended purpose. In particular, this well was designed to obtain data to evaluate the uncertainty in model forecasts of contaminant migration from the upgradient underground nuclear test MILK SHAKE, conducted in Emplacement Hole U-5k in 1968, which were considered to be uncertain due to the unknown extent of a basalt lava-flow aquifer present in this area. Well ER-5-5 is expected to provide information to refine the Phase II Frenchman Flat hydrostratigraphic framework model, if necessary, as well as to support future groundwater flow and transport modeling. The 31.1-centimeter (cm) diameter hole was drilled to a total depth of 331.3 meters (m). The completion string, set at the depth of 317.2 m, consists of 16.8-cm stainless-steel casing hanging from 19.4-cm carbon-steel casing. The 16.8-cm stainless-steel casing has one slotted interval open to the basalt lava-flow aquifer and limited intervals of the overlying and underlying alluvial aquifer. A piezometer string was also installed in the annulus between the completion string and the borehole wall. The piezometer is composed of 7.3-cm stainless-steel tubing suspended from 6.0-cm carbon-steel tubing. The piezometer string was landed at 319.2 m, to monitor the basalt lava-flow aquifer. Data collected during and shortly after hole construction include composite drill cuttings samples collected every 3.0 m, various geophysical logs, preliminary water quality measurements, and water-level measurements. The well penetrated 331.3 m of Quaternary–Tertiary alluvium, including an intercalated layer of saturated basalt lava rubble. No well development or hydrologic testing was conducted in this well immediately after completion; however, a preliminary water level was measured in the piezometer string at the depth of 283.4 m on September 25, 2012. No tritium above the minimum detection limit of the field instruments was detected in this hole. Future well development, sampling, and hydrologic testing planned for this well will provide more accurate hydrologic information for this site. The stratigraphy, general lithology, and water level were as expected, though the expected basalt lava-flow aquifer is basalt rubble and not the dense, fractured lava as modeled. The lack of tritium transport is likely due to the difference in hydraulic properties of the basalt lava-flow rubble encountered in the well, compared to those of the fractured aquifer used in the flow and transport models.

  17. Idaho National Engineering Laboratory (INEL) Environmental Restoration (ER) Program Baseline Safety Analysis File (BSAF)

    SciTech Connect (OSTI)

    NONE

    1995-09-01T23:59:59.000Z

    The Baseline Safety Analysis File (BSAF) is a facility safety reference document for the Idaho National Engineering Laboratory (INEL) environmental restoration activities. The BSAF contains information and guidance for safety analysis documentation required by the U.S. Department of Energy (DOE) for environmental restoration (ER) activities, including: Characterization of potentially contaminated sites. Remedial investigations to identify and remedial actions to clean up existing and potential releases from inactive waste sites Decontamination and dismantlement of surplus facilities. The information is INEL-specific and is in the format required by DOE-EM-STD-3009-94, Preparation Guide for U.S. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports. An author of safety analysis documentation need only write information concerning that activity and refer to BSAF for further information or copy applicable chapters and sections. The information and guidance provided are suitable for: {sm_bullet} Nuclear facilities (DOE Order 5480-23, Nuclear Safety Analysis Reports) with hazards that meet the Category 3 threshold (DOE-STD-1027-92, Hazard Categorization and Accident Analysis Techniques for Compliance with DOE Order 5480.23, Nuclear Safety Analysis Reports) {sm_bullet} Radiological facilities (DOE-EM-STD-5502-94, Hazard Baseline Documentation) Nonnuclear facilities (DOE-EM-STD-5502-94) that are classified as {open_quotes}low{close_quotes} hazard facilities (DOE Order 5481.1B, Safety Analysis and Review System). Additionally, the BSAF could be used as an information source for Health and Safety Plans and for Safety Analysis Reports (SARs) for nuclear facilities with hazards equal to or greater than the Category 2 thresholds, or for nonnuclear facilities with {open_quotes}moderate{close_quotes} or {open_quotes}high{close_quotes} hazard classifications.

  18. Enhanced 1.53??m emission of Er{sup 3+} ions in phosphate glass via energy transfer from Cu{sup +} ions

    SciTech Connect (OSTI)

    Jiménez, José A., E-mail: jose.jimenez@unf.edu [Department of Chemistry, University of North Florida, Jacksonville, Florida 32224 (United States); Sendova, Mariana [Optical Spectroscopy and Nano-Materials Lab, New College of Florida, Sarasota, Florida 34243 (United States)

    2014-07-21T23:59:59.000Z

    Optimizing the efficiency of Er{sup 3+} emission in the near-infrared telecommunication window in glass matrices is currently a subject of great interest in photonics research. In this work, Cu{sup +} ions are shown to be successfully stabilized at a high concentration in Er-containing phosphate glass by a single-step melt-quench method, and demonstrated to transfer energy to Er{sup 3+} thereby enhancing the near-infrared emission about 15 times. The spectroscopic data indicate an energy conversion process where Cu{sup +} ions first absorb photons broadly around 360?nm and subsequently transfer energy from the Stokes-shifted emitting states to resonant Er{sup 3+} absorption transitions in the visible. Consequently, the Er{sup 3+} electronic excited states decay and the {sup 4}I{sub 3/2} metastable state is populated, leading to the enhanced emission at 1.53??m. Monovalent copper ions are thus recognized as sensitizers of Er{sup 3+} ions, suggesting the potential of Cu{sup +} co-doping for applications in the telecommunications, solar cells, and solid-state lasing realizable under broad band near-ultraviolet optical pumping.

  19. Magnetic properties and magnetocaloric effects of Gd{sub x}Er{sub 1?x}Ga (0???x???1) compounds

    SciTech Connect (OSTI)

    Zheng, X. Q.; Wang, L. C.; Wu, R. R.; Hu, F. X.; Sun, J. R.; Shen, B. G., E-mail: shenbg@aphy.iphy.ac.cn [Institute of Physics, State key laboratory for Magnetism, Chinese Academy of Sciences, Beijing 100190 (China); Chen, J. [Beijing Institute of Aerospace Testing Technology, China Aerospace Science and Technology Corporation, Beijing 100074 (China)

    2014-05-07T23:59:59.000Z

    We carefully studied the magnetic properties and magnetocaloric effect of Gd{sub x}Er{sub 1-x}Ga (0???x???1) compounds. The Gd{sub x}Er{sub 1-x}Ga compounds undergo two magnetic transitions with temperature increasing: spin-reorientation or antiferromagnetic-to-ferromagnetic (FM) transition and FM-to-paramagnetic transition. As the content of Gd increases from 0 to 1, the transition temperature in low temperature region changes from 15?K to 66?K and the Curie temperature increases obviously from 30?K to 181.9?K. Although the maximum value of magnetic entropy change (?S{sub M}) for Gd{sub x}Er{sub 1?x}Ga decreases with the increase of x, the refrigerant capacity (RC) improves remarkably compared with that of ErGa compound. Table-like ?S{sub M} curves are observed for the compounds with x?=?0.1, 0.2, 0.3, and 0.4, which are very useful for real cooling applications. And Gd{sub 0.2}Er{sub 0.8}Ga and Gd{sub 0.3}Er{sub 0.7}Ga compounds show better magnetocaloric features than others in this series under considerations of both ?S{sub M} and RC. The results of this series of compounds show us a possible way to design and improve the magnetic refrigerant materials by making some substitutions.

  20. Long-range ferromagnetic order induced by a donor impurity band exchange in SnO{sub 2}:Er{sup 3+} nanoparticles

    SciTech Connect (OSTI)

    Aragón, F. H.; Coaquira, J. A. H. [Núcleo de Física Aplicada, Institute of Physics, University of Brasília, Brasília DF 70910-900 (Brazil); Chitta, V. A. [Instituto de Física, Universidade de São Paulo, São Paulo, SP 05508-000 (Brazil); Hidalgo, P. [Faculdade Gama-FGA, Sector Central Gama, Universidade de Brasília, Brasília, DF72405-610 (Brazil); Brito, H. F. [Instituto de Química, Universidade de São Paulo, São Paulo, SP 05508-000 (Brazil)

    2013-11-28T23:59:59.000Z

    In this work, the structural and magnetic properties of Er-doped SnO{sub 2} (SnO{sub 2}:Er) nanoparticles are reported. The SnO{sub 2}:Er nanoparticles have been synthesized by a polymer precursor method with Er content from 1.0% to 10.0%. X-ray diffraction results indicate the formation of only the rutile-type structure in all samples. The estimated mean crystallite size shows a decrease from ?10 to ?4?nm when the Er content is increased from 1.0% to 10.0%. The particle size values have been corroborated by transmission electron microscopy technique. The thermal dependence of the magnetization is consistent with the 3+ oxidation state of erbium ions for all samples. A strong paramagnetic-like behavior coexisting with a ferromagnetic phase has been determined for samples with Er content below 5.0%. Above this concentration, only a paramagnetic behavior has been determined. Isothermal magnetization curves are consistent with the occurrence of long-range ferromagnetic order mediated by donor electrons forming bound magnetic polarons which overlap to produce a spin-split impurity band.

  1. Upcoversion performance improvement of NaYF{sub 4}:Yb, Er by Sn codoping: Enhanced emission intensity and reduced decay time

    SciTech Connect (OSTI)

    Yu, Han, E-mail: fjfzyh@fzu.edu.cn [College of Materials Science and Engineering, Fuzhou University, Fuzhou, Fujian 350108 (China); Cao, Wenbing [College of Materials Science and Engineering, Fuzhou University, Fuzhou, Fujian 350108 (China); Huang, Qingming [Instrumentation Analysis and Research Center, Fuzhou University, Fuzhou, Fujian 350002 (China); Ma, En [Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002 (China); Zhang, Xinqi [Instrumentation Analysis and Research Center, Fuzhou University, Fuzhou, Fujian 350002 (China); Yu, Jianchang [College of Materials Science and Engineering, Fuzhou University, Fuzhou, Fujian 350108 (China)

    2013-11-15T23:59:59.000Z

    In this manuscript we report a phenomenon that upconversion emission intensity of Er{sup 3+} was enhanced while decay time constant was decreased obviously by Sn codoping with Yb/Er into hexagonal NaYF{sub 4} synchronously. X-ray powder diffiraction, field emission scanning electron microscope, transmission electron microscopy, X-ray photoelectron spectroscopy, electron spin-resonance spectroscopy and upconversion emission spectra were employed to explore the relation of crystal structure and properties. From these characterizations we found that symmetry of the rare earth ion local crystal field could be tuned by different Sn codoping concentration. For the variable valence property of Sn the local crystal field asymmetry and emission intensity of NaYF{sub 4}:Yb, Er arrived to the maximum when 3 mol% Sn was codoped, while decay time was reduced. The study of this changing tends of upconversion emission intensity and decay time constant may be helpful for design and fabrication of high performance upconversion materials. - Graphical abstract: Variable-valenced Sn is introduced with Yb/Er into NaFY{sub 4} to tune structure and local crystal field. Upconversion emission intensity of Er{sup 3+} was enhanced while decay time constant was decreased. Display Omitted - Highlights: • NaYF{sub 4}: Yb, Er was codoped with different concentration Sn. • Upconversion emission intensity was enhanced while decay time constant was decreased. • Introduction of variable-valenced Sn is effective to tune structure and crystal field of NaFY{sub 4}.

  2. Improved Laboratory Transition Probabilities for Er II and Applications to the Erbium Abundances of the Sun and Five r-Process Rich, Metal-Poor Stars

    E-Print Network [OSTI]

    J. E. Lawler; C. Sneden; J. J. Cowan; J. -F. Wyart; I. I. Ivans; J. S. Sobeck; M. H. Stockett; E. A. Den Hartog

    2008-04-28T23:59:59.000Z

    Recent radiative lifetime measurements accurate to +/- 5% (Stockett et al. 2007, J. Phys. B 40, 4529) using laser-induced fluorescence (LIF) on 8 even-parity and 62 odd-parity levels of Er II have been combined with new branching fractions measured using a Fourier transform spectrometer (FTS) to determine transition probabilities for 418 lines of Er II. This work moves Er II onto the growing list of rare earth spectra with extensive and accurate modern transition probability measurements using LIF plus FTS data. This improved laboratory data set has been used to determine a new solar photospheric Er abundance, log epsilon = 0.96 +/- 0.03 (sigma = 0.06 from 8 lines), a value in excellent agreement with the recommended meteoric abundance, log epsilon = 0.95 +/- 0.03. Revised Er abundances have also been derived for the r-process-rich metal-poor giant stars CS 22892-052, BD+17 3248, HD 221170, HD 115444, and CS 31082-001. For these five stars the average Er/Eu abundance ratio, = 0.42, is in very good agreement with the solar-system r-process ratio. This study has further strengthened the finding that r-process nucleosynthesis in the early Galaxy which enriched these metal-poor stars yielded a very similar pattern to the r-process which enriched later stars including the Sun.

  3. Structural and ambient/sub-ambient temperature magnetic properties of Er-substituted cobalt-ferrites synthesized by sol-gel assisted auto-combustion method

    SciTech Connect (OSTI)

    Prathapani, Sateesh [School of Engineering Sciences and Technology, University of Hyderabad, Hyderabad 500046 (India); Department of Metallurgical Engineering and Materials Science, IIT-Bombay, Mumbai 400076 (India); Jayaraman, Tanjore V., E-mail: ddas@uohyd.ernet.in, E-mail: tvjayaraman@gmail.com [Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, Nebraska 68588 (United States); Varaprasadarao, Eswara K. [Department of Metallurgical Engineering and Materials Science, IIT-Bombay, Mumbai 400076 (India); Das, Dibakar, E-mail: ddas@uohyd.ernet.in, E-mail: tvjayaraman@gmail.com [School of Engineering Sciences and Technology, University of Hyderabad, Hyderabad 500046 (India)

    2014-07-14T23:59:59.000Z

    Er-substituted cobalt-ferrites CoFe{sub 2?x}Er{sub x}O{sub 4} (0???x???0.04) were synthesized by sol-gel assisted auto-combustion method. The precursor powders were calcined at 673–873?K for 4?h, subsequently pressed into pellets and sintered at 1273?K for 4?h. X-ray diffraction (XRD) confirmed the presence of the spinel phase for all the compositions and, additional orthoferrite phase for higher compositions (x?=?0.03 and 0.04). The XRD spectra and the Transmission Electron Microscopy micrographs indicate that the nanocrystalline particulates of the Er-substituted cobalt ferrites have crystallite size of ?120–200?nm. The magnetization curves show an increase in saturation magnetization (M{sub S}) and coercivity (H{sub C}) for Er-substituted cobalt-ferrites at sub-ambient temperatures. M{sub S} for CoFe{sub 2}O{sub 4}, CoFe{sub 0.99}Er{sub 0.01}O{sub 4}, CoFe{sub 0.98}Er{sub 0.02}O{sub 4}, and CoFe{sub 0.97}Er{sub 0.03}O{sub 4} peak at 89.7?Am{sup 2}/kg, 89.3?Am{sup 2}/kg, 88.8?Am{sup 2}/kg, and 87.1?Am{sup 2}/kg, respectively, at a sub-ambient temperature of ?150?K. H{sub C} substantially increases with decrease in temperature for all the compositions, while it peaks at x?=?0.01?0.02 at all temperatures. The combination of Er content—x???0.02 and the temperature—?5?K provides the maximum H{sub C}???984?kA/m. Er-substituted cobalt-ferrites have higher cubic anisotropy constant, K{sub 1}, compared to pure cobalt-ferrite at ambient/sub-ambient temperatures. K{sub 1} gradually increases for all compositions in the temperature decreasing from 300 to 100?K. While K{sub 1} peaks at ?150?K for pure cobalt-ferrite, it peaks at ?50?K for CoFe{sub 0.99}Er{sub 0.01}O{sub 4}, CoFe{sub 0.98}Er{sub 0.02}O{sub 4}, and CoFe{sub 0.96}Er{sub 0.04}O{sub 4}. The M{sub S} (?88.7?Am{sup 2}/kg), at 5?K, for Er substituted cobalt-ferrite is close to the highest values reported for Sm and Gd substituted cobalt-ferrites. The M{sub S} (?83.5?Am{sup 2}/kg) at 300?K for Er-substituted cobalt-ferrite is the highest among the lanthanide series element substituted cobalt-ferrites. The H{sub C} (at 5?K) for Er substituted cobalt-ferrite is close to the highest values observed for La, Ce, Nd, Sm, and Gd substituted cobalt-ferrites.

  4. Investigation of the use of an Er:YAG laser and a fluoride glass fiber for laser angioplasty 

    E-Print Network [OSTI]

    Kwark, Bongsin

    1989-01-01T23:59:59.000Z

    is attracting the attention of inany invest&- gators, 'I]. Although many lasers ( c. y. , Ar ion. Nd: YAC(, and excimer) have been tried for laser angioplasty, no clear winner has enierged. Recently it has been suggested that the erbium: yttrium aluminum...INVESTIGATION OF THE USE OF AN ER:YAG LASER AND A FLUORIDE ClLASS FIBER FOR LASER ANGIOPLASTY A Thes&s BONC'SIN KA'ARK Submitted to the Office of Clraduate Sturlies of Texas A&M University in partial fulfillment of the requirements...

  5. Completion Report for Well ER-20-4 Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    SciTech Connect (OSTI)

    NSTec Environmental Management

    2011-04-30T23:59:59.000Z

    Well ER-20-4 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada National Security Site, Nye County, Nevada. The well was drilled in August and September 2010 as part of the Pahute Mesa Phase II drilling program. The primary purpose of the well was to investigate the possibility of radionuclide transport from up-gradient underground nuclear tests conducted in central Pahute Mesa. This well also provided detailed hydrogeologic information in the Tertiary volcanic section that will help reduce uncertainties within the Pahute Mesa-Oasis Valley hydrostratigraphic framework model.

  6. Final Report for DOE grant project FG02-07ER41458 [Dense Quark Matter in Magnetic Fields

    SciTech Connect (OSTI)

    Incera, Vivian

    2012-01-24T23:59:59.000Z

    Final Report for DOE grant DE-FG02-07ER41458. This grant was originally a three-year project. However, this final report summarizes the results of the first two years, as at the end of the second year of the grant the PIs moved to a new university and the grant was closed. The work done under the first two years of the DOE grant led to several papers and presentations. It also served to train one undergraduate and three graduate students.

  7. Huntingtin is required for ER-to-Golgi transport and for secretory vesicle fusion at the plasma membrane

    E-Print Network [OSTI]

    Brandstaetter, Hemma; Kruppa, Antonina J.; Buss, Folma

    2014-10-31T23:59:59.000Z

    et al., 2009; Presley et al., 1997; Roghi and Allan, 1999). To determine whether compromising dynein activity affects the ER-to-Golgi GFP-hGH transport assay, we performed siRNA knockdown of the dynein associated intermediate chain (DIC... cells. Nature. 389:81-85. Roghi, C., and V.J. Allan. 1999. Dynamic association of cytoplasmic dynein heavy chain 1a with the Golgi apparatus and intermediate compartment. J Cell Sci. 112 ( Pt 24):4673-4685. Sahlender, D.A., R.C. Roberts, S.D. Arden...

  8. Social Influences on Food Choices of Norway Rats and Mate Choices of Japanese Quail

    E-Print Network [OSTI]

    Galef, Jr., Bennett G.

    2001-01-01T23:59:59.000Z

    ecology and sociology of the Norway rat . Bethesda: U.S. De-food stealing by young Norway rats. Journal of Comparativesufficient diet by Norway rats. Journal of Comparative

  9. Demography of auklets Aethia spp. in relation to introduced Norway rats Rattus norvegicus at Kiska

    E-Print Network [OSTI]

    Jones, Ian L.

    Demography of auklets Aethia spp. in relation to introduced Norway rats Rattus norvegicus at Kiska................................................................................................4 Norway Rat Abundance and Distribution .........................................................5................................................................................................6 Norway Rat Abundance and Distribution.........................................................7

  10. Discrimination between energy transfer and back transfer processes for GaAs host and Er luminescent dopants using electric response analysis

    SciTech Connect (OSTI)

    Ishii, Masashi, E-mail: ISHII.Masashi@nims.go.jp [National Institute for Materials Science (NIMS), Tsukuba, Ibaraki 305-0047 (Japan); Koizumi, Atsushi; Fujiwara, Yasufumi [Division of Materials and Manufacturing Science, Graduate School of Engineering Osaka University, Suita, Osaka 565-0871 (Japan); Takeda, Yoshikazu [Nagoya Industrial Science Research Institute, Nagoya, Aichi 464-0819 (Japan)

    2014-04-07T23:59:59.000Z

    The energy transfer and back transfer processes of GaAs co-doped with Er and O (GaAs:Er,O) were experimentally distinguished by using a frequency response analysis of the AC photocurrent. The results were achieved by using the difference in the frequency dispersion between (1) the dispersion of the energy transfer, which is triggered by the trapping of free charges in the GaAs host and is represented with the Debye relaxation response and (2) the dispersion of the energy back transfer, which is induced by non-radiative transition of 4f bound electrons in the Er dopants and is described with a Lorentzian. The Debye relaxation response found in GaAs:Er,O provided a charge trapping time that was dependent on temperature, which was well correlated with the thermal quenching property of intense intra-4f-shell luminescence. The spectral shape of the Lorentzian dependence on the temperature was explained with the thermal excitation of Er 4f electrons and release of trapped charges in GaAs. The thermal excitation and release of charges consistently explained the characteristics of weak 4f luminescence in low- and high-temperature regions, respectively.

  11. Luminescence thermometry below room temperature via up-conversion emission of Y{sub 2}O{sub 3}:Yb{sup 3+},Er{sup 3+} nanophosphors

    SciTech Connect (OSTI)

    Lojpur, V.; Nikoli?, G.; Drami?anin, M. D., E-mail: dramican@vinca.rs [Vin?a Institute of Nuclear Sciences, University of Belgrade, P.O. Box 522, Belgrade 11001 (Serbia)

    2014-05-28T23:59:59.000Z

    This study explores potential of Er{sup 3+}-Yb{sup 3+} doped phosphors for up-conversion luminescence thermometry in the temperature range from 10?K to 300?K. Yttrium oxide nanopowder doped with trivalent ytterbium and erbium ions (Y{sub 1.97}Yb{sub 0.02}Er{sub 0.01}O{sub 3}) was prepared by hydrothermal synthesis as an example. The intensity ratios of up-conversion emissions from thermally coupled {sup 2}H{sub 11/2} and {sup 4}S{sub 3/2} levels of Er{sup 3+} show strong temperature dependence (in the range 150?K–300?K) with much higher relative sensitivity than those reported for thermometry above room temperature with Er{sup 3+}-Yb{sup 3+} based up-conversion materials. The maximal value of relative sensitivity is 5.28%K{sup ?1} at 150?K, with temperature resolution ranging from 0.81?K to 0.06?K. In addition, the intensity ratios of emission from thermally non-coupled Er{sup 3+} levels ({sup 2}H{sub 9/2} and {sup 4}F{sub 9/2}) and from {sup 4}S{sub 3/2} also show temperature dependence that can be approximated with an exponential function. With these up-conversion emission ratios, it is possible measure temperature in the range of 10?K to 300?K with excellent sensitivity and resolution.

  12. Optical properties and energy transfer processes of Ho{sup 3+}/Er{sup 3+}- codoped fluorotellurite glass under 1550?nm excitation for 2.0??m applications

    SciTech Connect (OSTI)

    Huang, Feifei; Liu, Xueqiang [Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China); Graduate School of Chinese Academy of Sciences, Beijing 100039 (China); Hu, Lili; Chen, Danping, E-mail: dpchen2008@aliyun.com [Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China)

    2014-07-21T23:59:59.000Z

    This paper investigates 2.0??m emission properties and energy transfer processes in the Er{sup 3+}/Ho{sup 3+} codoped fluorotellurite glass. The measured absorption spectra demonstrate that the codoped sample can be pumped by 1550?nm excitation efficiently. Judd-Ofelt and radiative parameters are calculated and discussed. Intensive 2.0??m emission originating from Ho{sup 3+}: {sup 5}I{sub 7}?{sup 5}I{sub 8} transition is observed and a long lifetime (11?ms) of the {sup 5}I{sub 7} level is measured when Ho{sup 3+} ions are sensitized by Er{sup 3+} ions. Meanwhile, the upconversion spectra of the Er{sup 3+} singly and codoped samples are obtained and the energy transfer processes of the two ions is discussed based on the change of the upconversion emissions. The microscopic interaction parameters of the phonon-assisted (Er{sup 3+}: {sup 4}I{sub 13/2}?Ho{sup 3+}:{sup 5}I{sub 7}) process are calculated and the microparameter reaches as high as 10.1?×?10{sup ?41} cm{sup 6}/s. Hence, these results indicate that this Ho{sup 3+}/Er{sup 3+} codoped fluorotellurite glass will be a suitable material for developing solid state laser around 2.0??m.

  13. FInal Report: DE-FG02-04ER41310 "Elementary Particle Physics"

    SciTech Connect (OSTI)

    Izen, Joseph M. [University of Texas at Dallas] [University of Texas at Dallas; Ishak-Boushaki, Mustapha [University of Texas at Dallas] [University of Texas at Dallas

    2013-10-18T23:59:59.000Z

    ATLAS and the LHC are delivering on the promise of discovery physics at the high energy frontier. Using 4.8 fb^-1 of 2011 ?s=7 TeV data and the first 5.8 fb?1 of 2012 ?s=8 TeV data, ATLAS published the observation of a new particle with a mass of 126 GeV with a significance of 5.9? that is compatible with a Standard Model (SM) Higgs. The LHC is outperforming intial projections for the 2012 run, and ATLAS is on track to integrate ~20 fb^(-1) of proton-proton collisions in 2012 before Long Shutdown 1 (LS1) begins in Spring 2013. University of Texas at Dallas (UTD) physicists will complete work on two ATLAS analyses this fall. The first is the search for the gauge bosons of a hypothesized dark sector. For 2011 data, UTD is responsible for the ?dark photon?search in the electron-jet channel, and we are looking forward to an expanded leadership role in the dark photon search using the full 2012 data set. Our second analysis interest is the study of X/Y/Z exotic states having cc ? content, which builds on our experience in this field from the BABAR experiment After completing a measurement of the Xc(3872) production cross section this fall, we will search for evidence of the Z(4430)+ which is reported by Belle but not confirmed by BABAR. The UTD group has played a strong role in ATLAS operations, with group members serving as Pixel Run Coordinator, ATLAS Shift Leader, and Pixel/Inner Detector Shifter. For most of the current 3-year funding cycle, a group member coordinated the development of the Pixel DAQ code, and another continues to build and maintain the data quality monitoring (DQM) application that is used by the Inner Detector control room shifter. Additionally, members of our group take Pixel on-call expert shifts for DQM and DAQ. We led an optoboard lifetime study to assess concerns of premature on-detector VCSEL failure using the Pixel working prototype detector at CERN. Physicists based at UTD participated through Pixel Offline DQM and ATLAS Distributed Computing Operations Shifts (ADCoS) During Summer 2012, UTD joined upgrade activities in preparation for LS1. We took a major role in the testing of Electro-Readout (ER) Bundle testing for new Service Quarter Panels (nSQP?s), and we developed two utilities to measure the timing jitter and bit error rate of the Pixel readout chain for use commissioning Pixel detector upgrades. During BABAR?s heyday, the UTD group pioneered the use of e^+ e^- annihilation events with hard Initial State Radiation (ISR) to study the charm threshold region, and we carried out the first BABAR double-cc ? analysis. Our most recent ISR paper, written in collaboration with A. Palano (Bari) is Exclusive Production of Ds^+ Ds^-, D_S^(*+) Ds^-, and Ds^(*+) Ds^(*-) via e+ e- Annihilation with Initial-State-Radiation was published in Physical Review D 82, 052004 (2010). Work continues on a study of ISR ?c^+ ?c^- production, and a new search to establish and study double-ss ? production is starting.

  14. Completion Report for Well ER-EC-14, Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    SciTech Connect (OSTI)

    None

    2013-03-05T23:59:59.000Z

    Well ER-EC-14 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Management Operations Underground Test Area (UGTA) Activity at the Nevada National Security Site (NNSS; formerly Nevada Test Site), Nye County, Nevada. The well was drilled in September and October 2012, as part of the Central and Western Pahute Mesa Corrective Action Unit Phase II drilling program. The primary purpose of the well was to provide detailed hydrogeologic information for the Fortymile Canyon composite hydrostratigraphic unit in the Timber Mountain moat area, within the Timber Mountain caldera complex, that will help address uncertainties within the Pahute Mesa–Oasis Valley hydrostratigraphic framework model. The main 55.9-centimeter (cm) hole was drilled to a total depth of 325.5 meters (m) and cased with 40.6-cm casing to 308.1 m. The hole diameter was then decreased to 37.5 cm, and drilling continued to a total depth of 724.8 m. The completion casing string, set to the depth of 690.9 m, consists of 16.8-cm stainless-steel casing hanging from 19.4-cm carbon-steel casing. The stainless-steel casing has two slotted intervals open to the Rainier Mesa Tuff. Two piezometer strings were installed in Well ER-EC-14. Both piezometer strings, each with one slotted interval, consist of 6.0-cm carbon-steel tubing at the surface, then cross over to 7.3-cm stainless-steel tubing just above the water table. The shallow piezometer string was landed at 507.8 m, and the deep piezometer string was landed at 688.6 m. Both piezometer strings are set to monitor groundwater within moderately to densely welded Rainier Mesa Tuff. Data collected during and shortly after hole construction include composite drill cuttings samples collected every 3.0 m, various geophysical logs, water quality (including tritium and other radionuclides) measurements, and water level measurements. The well penetrated 15.2 m of alluvium and 709.6 m of Tertiary volcanic rocks. The stratigraphy and general lithology were not as expected due to the position of Well ER-EC-14 relative to the buried caldera margins of the Timber Mountain caldera complex. The well is located inside the Rainier Mesa caldera, but outside the younger Ammonia Tanks caldera. On November 5, 2012, a preliminary fluid level in the shallow piezometer string was measured at the depth of 311.8 m. This water level depth was taken before installation of the bridge plug (to be placed within the main completion casing to separate the two slotted zones). Well development, hydrologic testing, and sampling, will be conducted at a later date. No tritium above levels detectable by field methods were encountered in this hole. All Fluid Management Plan (FMP) requirements for Well ER-EC-14 were met. Analysis of monitoring samples and FMP confirmatory samples indicated that fluids generated during drilling at Well ER-EC-14 met the FMP criteria for discharge to an unlined sump or designated infiltration area. All sanitary and hydrocarbon waste generated was properly handled and disposed of.

  15. Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Nicotine in Rat Brain Tissue by Use of Nanospray Desorption Electrospray Ionization Mass Spectrometry. Imaging Nicotine in Rat Brain Tissue by Use of Nanospray Desorption...

  16. E-Print Network 3.0 - adult rat liver Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    from normal rat liver and incubated for 3 or 16 hours with increasing doses... of carbon tetrachloride (CCl4). Rat ... Source: Groningen, Rijksuniversiteit - Centre for...

  17. adult rat vestibular: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    stimulate cell proliferation in adult rat vestibular sensory epithelia, as does the infusion of transforming growth factor alpha (TGF ) plus insulin. We sought to determine...

  18. Suppressed serum prolactin in sinoaortic-denervated rats

    SciTech Connect (OSTI)

    Alexander, N.; Melmed, S.; Morris, M.

    1987-02-01T23:59:59.000Z

    The authors investigated the effect of arterial baroreceptor deafferentation on serum and pituitary prolactin (PRL) and on catecholamines in median eminence (ME) and anterior and posterior pituitaries. Male Wistar rats were sinoaortic denervated (SAD) or sham operated (SO). Three days after surgery serum prolactin, measured by radioimmunoassay, was suppressed in SAD rats, and dopamine (DA) and norepinephrine (NE) concentrations, measured by radioenzymatic or high-performance liquid chromatography electron capture methods, were significantly reduced in ME of SAD rats. Simultaneously, anterior pituitary of SAD rats had significant increases in both catecholamines, whereas posterior pituitary showed no changes. Four hours after surgery serum PRL was also reduced in SAD rats, but no changes in ME catecholamines were found. Mean arterial pressure (MAP) and heart rate were measured before and after injection of bromocriptine in SAD and SO rats 3 days after surgery. Bromocriptine markedly suppressed serum PRL in both groups and reduced MAP from 144 +/- 10 to 84 +/- 5 and from 116 +/- 2 to 99 +/- 3 in SAD and SO rats, respectively; heart rate was reduced in SAD rats. They conclude that the SAD rat is a model of hypertension with suppressed serum PRL and that interruption of arterial baroreceptor nerves suppresses PRL secretion probably by modulating tuberoinfundibular turnover of catecholamines.

  19. Chemical Renal Denervation in the Rat

    SciTech Connect (OSTI)

    Consigny, Paul M., E-mail: paul.consigny@av.abbott.com; Davalian, Dariush, E-mail: dariush.davalian@av.abbott.com [Abbott Vascular, Innovation Incubator (United States); Donn, Rosy, E-mail: rosy.donn@av.abbott.com; Hu, Jie, E-mail: jie.hu@av.abbott.com [Abbott Vascular, Bioanalytical and Material Characterization (United States); Rieser, Matthew, E-mail: matthew.j.rieser@abbvie.com; Stolarik, DeAnne, E-mail: deanne.f.stolarik@abbvie.com [Abbvie, Analytical Pharmacology (United States)

    2013-12-03T23:59:59.000Z

    Introduction: The recent success of renal denervation in lowering blood pressure in drug-resistant hypertensive patients has stimulated interest in developing novel approaches to renal denervation including local drug/chemical delivery. The purpose of this study was to develop a rat model in which depletion of renal norepinephrine (NE) could be used to determine the efficacy of renal denervation after the delivery of a chemical to the periadventitial space of the renal artery. Methods: Renal denervation was performed on a single renal artery of 90 rats (n = 6 rats/group). The first study determined the time course of renal denervation after surgical stripping of a renal artery plus the topical application of phenol in alcohol. The second study determined the efficacy of periadventitial delivery of hypertonic saline, guanethidine, and salicylic acid. The final study determined the dose–response relationship for paclitaxel. In all studies, renal NE content was determined by liquid chromatography–mass spectrometry. Results: Renal NE was depleted 3 and 7 days after surgical denervation. Renal NE was also depleted by periadventitial delivery of all agents tested (hypertonic saline, salicylic acid, guanethidine, and paclitaxel). A dose response was observed after the application of 150 ?L of 10{sup ?5} M through 10{sup ?2} M paclitaxel. Conclusion: We developed a rat model in which depletion of renal NE was used to determine the efficacy of renal denervation after perivascular renal artery drug/chemical delivery. We validated this model by demonstrating the efficacy of the neurotoxic agents hypertonic saline, salicylic acid, and guanethidine and increasing doses of paclitaxel.

  20. Up-conversion luminescence in Er{sup 3+}/Yb{sup 3+}-codoped PbTiO{sub 3} perovskite obtained via Pechini method

    SciTech Connect (OSTI)

    Lemos, F.C.D. [Departamento de Quimica, Universidade Federal do Rio Grande do Norte, C.P. 1605 CEP 59078-970, Natal, RN (Brazil); Melo, D.M.A. [Departamento de Quimica, Universidade Federal do Rio Grande do Norte, C.P. 1605 CEP 59078-970, Natal, RN (Brazil); Silva, J.E.C. da [Campus de Araguaina, Universidade Federal do Tocantins, R. Humberto de Campus, 508, B. Sao Joao, CEP 77807-060, Araguaina, TO (Brazil)]. E-mail: jecs@uft.edu.br

    2005-01-04T23:59:59.000Z

    Efficient infrared-to-visible conversion by Er{sup 3+}/Yb{sup 3+}-codoped PbTiO{sub 3} perovskite will be reported. The process is observed under 980 nm laser diode (GAs:Si) excitation and results in the generation of green ({approx}555 nm) and red ({approx}655 nm) emission. The main mechanism that allows for up-conversion is attributed the energy transfer among Yb and Er ions in excited states. The power up-conversion efficiency for red emission is predominant in this material. The results illustrate the large potential of this new class of material for photonic applications involving optoelectronics devices.

  1. DE-FG02-08ER64658 (OASIS) - Final Technical Report

    SciTech Connect (OSTI)

    Sharman, Jonathan

    2013-09-05T23:59:59.000Z

    Project OASIS (Operation of Advanced Structures, Interfaces and Sub-components for MEAs) was a 12 month project that ran from 1st September 2008 to 31st August 2009, and was managed by the Department of Energy Office of Science, Chicago Office, as Award No DE-FG02-08ER64658, with Johnson Matthey Fuel Cells Inc. as the sole contractor. The project was completed on schedule, with technical successes (details below) and payment of the full grant award made by DOE. The aim of the project was the development of membrane electrode assemblies (MEAs) for H2/air polymer electrolyte membrane (PEM) fuel cells that would give higher performance under hot/dry and dry operating conditions, ideally with no loss of performance under wet conditions. Reducing or eliminating the need for humidifying the incoming gases will allow significant system cost and size reduction for many fuel cell applications including automotive, stationary and back-up power, and portable systems. Portable systems are also of particular interest in military markets. In previous work Johnson Matthey Fuel Cells had developed very stable, corrosion-resistant catalysts suitable for resisting degradation by carbon corrosion in particular. These materials were applied within the OASIS project as they are considered necessary for systems such as automotive where multiple start-stop events are experienced. These catalysts were contrasted with more conventional materials in the design of catalyst layers and novel microporous layers (MPLs) and gas diffusion layer (GDL) combinations were also explored. Early on in the work it was shown how much more aggressive high temperature operation is than dry operation. At the same humidity, tests at 110?C caused much more dehydration than tests at 80?C and the high temperature condition was much more revealing of improvements made to MEA design. Alloy catalysts were introduced and compared with Pt catalysts with a range of particle sizes. It was apparent that the larger particle sizes of the alloy catalysts led to a reduction in performance that offset much of their kinetic advantage. The Pt-only materials clearly showed that small particles are beneficial to good performance under hot/dry conditions, because of their higher surface area, although they are known to be less stable to cyclic operation. An ex-situ water vapour sorption technique was developed that showed a very clear correlation with in-cell performance: catalyst powders that absorbed more water gave better performance in-cell. It was shown that alloy catalysts could give a 25 mV advantage over Pt-only at 1 Acm-2. GDL design was also shown to influence performance and more permeable GDLs on the anode allowed better membrane hydration and therefore conductivity. A very impermeable GDL on the cathode caused cathode flooding even under dry conditions, but a novel cathode MPL incorporating ionomer and operating at 110?C, 33/17% RH showed a 150 mV gain at 800 mAcm-2 over the conventional MPL. This project has increased the understanding of the factors that influence performance loss under dry conditions, including the development of an insightful ex-situ characterisation technique (Dynamic Vapour Sorption). All the approaches investigated can be readily implemented in state-of the-art MEAs, although optimisation would be needed to integrate the new designs with existing MEA types and to tune to the exact range of operating conditions. The work is thus expected to benefit the public by feeding through more condition-tolerant production MEAs to a range of applications and thereby accelerate the commercialisation of fuel cell technology. In summary, a number of specific catalyst, catalyst layer, MPL and GDL improvements were made during this project. Often the best designs under dry conditions translated to some performance loss under wet conditions, but compromise situations were also found where dry performance was improved with no loss of wet performance.

  2. Ultrastructural development of the rat corpus luteum

    E-Print Network [OSTI]

    Bailey, John Franklin

    1971-01-01T23:59:59.000Z

    ' -GCL ttlrcughoLL't r and in concci -ated focal points, in the cytoclasm. The c-. "ccnt=ationls took on the conf igLLration of -whorls 3, 1?' "Je e;. i1?i?n tile nate Dale, Oilee, 1/ie pa'raSOI&e were ?lost numerous 4-6 days after ovLllati on, but i.... er. The buffer u' ilizec. was s-colli- dine Cock solut! on which . ;as prepared as 2. 67 ca. ts s-coll c i!6 & 9 part, hyd rochlor ic acid, ? nd BG. "j3 part" distilled water. Sucrose was added to th. 's fixative-buffer solution at the rate of 0...

  3. Ultrastructural development of the rat corpus luteum 

    E-Print Network [OSTI]

    Bailey, John Franklin

    1971-01-01T23:59:59.000Z

    ' -GCL ttlrcughoLL't r and in concci -ated focal points, in the cytoclasm. The c-. "ccnt=ationls took on the conf igLLration of -whorls 3, 1?' "Je e;. i1?i?n tile nate Dale, Oilee, 1/ie pa'raSOI&e were ?lost numerous 4-6 days after ovLllati on, but i.... er. The buffer u' ilizec. was s-colli- dine Cock solut! on which . ;as prepared as 2. 67 ca. ts s-coll c i!6 & 9 part, hyd rochlor ic acid, ? nd BG. "j3 part" distilled water. Sucrose was added to th. 's fixative-buffer solution at the rate of 0...

  4. Relativistic energy density functionals: Low-energy collective states of {sup 240}Pu and {sup 166}Er

    SciTech Connect (OSTI)

    Li, Z. P. [Physics Department, Faculty of Science, University of Zagreb, 10000 Zagreb (Croatia); State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing 100871 (China); School of Physical Science and Technology, Southwest University, Chongqing 400715 (China); Niksic, T.; Vretenar, D. [Physics Department, Faculty of Science, University of Zagreb, 10000 Zagreb (Croatia); Ring, P. [State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing 100871 (China); Physik-Department der Technischen Universitaet Muenchen, D-85748 Garching (Germany); Meng, J. [State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing 100871 (China); School of Physics and Nuclear Energy Engineering, Beihang University, Beijing 100191 (China)

    2010-06-15T23:59:59.000Z

    The empirical relativistic density-dependent, point-coupling energy density functional, adjusted exclusively to experimental binding energies of a large set of deformed nuclei with Aapprox =150-180 and Aapprox =230-250, is tested with spectroscopic data for {sup 166}Er and {sup 240}Pu. Starting from constrained self-consistent triaxial relativistic Hartree-Bogoliubov calculations of binding energy maps as functions of the quadrupole deformation in the beta-gamma plane, excitation spectra and E2 transition probabilities are calculated as solutions of the corresponding microscopic collective Hamiltonian in five dimensions for quadrupole vibrational and rotational degrees of freedom and compared with available data on low-energy collective states.

  5. Role of silicon excess in Er-doped silicon-rich nitride light emitting devices at 1.54??m

    SciTech Connect (OSTI)

    Ramírez, J. M., E-mail: jmramirez@el.ub.edu; Berencén, Y.; Garrido, B. [MIND-IN2UB, Department Electrònica, Universitat de Barcelona, Martí i Franquès 1, Barcelona 08028 (Spain); Cueff, S. [Institut des Nanotechnologies de Lyon, École Centrale de Lyon, Écully 69134 (France); Labbé, C. [Centre de Recherche sur les Ions, les Matériaux et la Photonique (CIMAP), UMR 6252 CNRS/CEA/Ensicaen/UCBN, Caen 14050 (France)

    2014-08-28T23:59:59.000Z

    Erbium-doped silicon-rich nitride electroluminescent thin-films emitting at 1.54??m have been fabricated and integrated within a metal-oxide-semiconductor structure. By gradually varying the stoichiometry of the silicon nitride, we uncover the role of silicon excess on the optoelectronic properties of devices. While the electrical transport is mainly enabled in all cases by Poole-Frenkel conduction, power efficiency and conductivity are strongly altered by the silicon excess content. Specifically, the increase in silicon excess remarkably enhances the conductivity and decreases the charge trapping; however, it also reduces the power efficiency. The main excitation mechanism of Er{sup 3+} ions embedded in silicon-rich nitrides is discussed. The optimum Si excess that balances power efficiency, conductivity, and charge trapping density is found to be close to 16%.

  6. Single and two-photon fluorescence control of Er{sup 3+} ions by phase-shaped femtosecond laser pulse

    SciTech Connect (OSTI)

    Zhang, Shian, E-mail: sazhang@phy.ecnu.edu.cn; Ding, Jingxin; Lu, Chenhui; Jia, Tianqing; Sun, Zhenrong, E-mail: zrsun@phy.ecnu.edu.cn [State Key Laboratory of Precision Spectroscopy, and Department of Physics, East China Normal University, Shanghai 200062 (China)] [State Key Laboratory of Precision Spectroscopy, and Department of Physics, East China Normal University, Shanghai 200062 (China); Xu, Shuwu [State Key Laboratory of Precision Spectroscopy, and Department of Physics, East China Normal University, Shanghai 200062 (China) [State Key Laboratory of Precision Spectroscopy, and Department of Physics, East China Normal University, Shanghai 200062 (China); School of Science, Nantong University, Nantong 226007 (China); Qiu, Jianrong [State Key Laboratory of Luminescent Materials and Devices, and Institute of Optical Communication Materials, South China University of Technology, Wushan Road 381, Guangzhou 510640 (China)] [State Key Laboratory of Luminescent Materials and Devices, and Institute of Optical Communication Materials, South China University of Technology, Wushan Road 381, Guangzhou 510640 (China)

    2014-01-06T23:59:59.000Z

    We experimentally demonstrate the control of the single and two-photon fluorescence (SPF and TPF) in Er{sup 3+} ions by shaping the femtosecond laser pulse with a ? or square phase modulation. With the low laser intensity (8.4?×?10{sup 10}?W/cm{sup 2}), SPF keeps a constant while TPF is effectively suppressed by the two control schemes. With the high laser intensity (1.2?×?10{sup 13}?W/cm{sup 2}), both SPF and TPF are simultaneously enhanced or suppressed by the ? phase modulation, and SPF is enhanced while TPF is effectively suppressed by the square phase modulation. The up/down-conversion fluorescence enhancement, suppression, or tuning by the optical control method can greatly expand its applications in various related fields.

  7. Well Completion Report for Well ER-20-11, Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    SciTech Connect (OSTI)

    NSTec Environmental Management

    2013-02-27T23:59:59.000Z

    Well ER-20-11 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Management Operations Underground Test Area (UGTA) Activity at the Nevada National Security Site (formerly Nevada Test Site), Nye County, Nevada. The well was drilled in September 2012 as part of the Central and Western Pahute Mesa Corrective Action Unit Phase II drilling program. Well ER-20-11 was constructed to further investigate the nature and extent of radionuclidecontaminated groundwater encountered in two nearby UGTA wells, to help define hydraulic and transport parameters for the contaminated Benham aquifer, and to provide data for the UGTA hydrostratigraphic framework model. The 44.5-centimeter (cm) surface hole was drilled to a depth of 520.0 meters (m) and cased with 34.0-cm casing to 511.5 m. The hole diameter was then decreased to 31.1 cm, and the borehole was drilled to a total depth of 915.6 m. The hole was completed to allow access for hydrologic testing and sampling in the target aquifer, which is a lava-flow aquifer known as the Benham aquifer. The completion casing string, set to the depth of 904.3 m, consists of a string of 6?-inch (in.) stainless-steel casing hanging from a string of 7?-in. carbon-steel casing. The stainless-steel casing has one slotted interval at 796.3 to 903.6 m. One piezometer string was installed, which consists of 2?-in. stainless-steel tubing that hangs from 2?-in. carbon-steel tubing via a crossover sub. This string was landed at 903.8 m and is slotted in the interval 795.3 to 903.1 m. Data collected during and shortly after hole construction include composite drill cuttings samples collected every 3.0 m, various geophysical logs, fluid samples (for groundwater chemistry analysis and tritium measurements), and water-level measurements. The well penetrated 915.6 m of Tertiary volcanic rock, including one saturated lava flow aquifer. Measurements on samples taken from the undeveloped well indicated elevated tritium levels within the Benham aquifer. The maximum tritium level measured with field equipment was 146,131 picocuries per liter from a sample obtained at the depth of 912.0 m. The fluid level was measured in the piezometer string at a depth of 504.5 m on September 26, 2012. All Fluid Management Plan (FMP) requirements for Well ER-20-11 were met. Analysis of monitoring samples and FMP confirmatory samples indicated that fluids generated during drilling at Well ER-20-11 met the FMP criteria for discharge to an unlined sump or designated infiltration area. Well development, hydrologic testing, and sampling will be conducted at a later date.

  8. Completion Report for Well ER-EC-12 Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    SciTech Connect (OSTI)

    NSTec Environmental Management

    2011-04-30T23:59:59.000Z

    Well ER-EC-12 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada National Security Site (formerly known as the Nevada Test Site), Nye County, Nevada. The well was drilled in June and July 2010 as part of the Pahute Mesa Phase II drilling program. The primary purpose of the well was to provide detailed hydrogeologic information in the Tertiary volcanic section in the area between Pahute Mesa and the Timber Mountain caldera complex that will help address uncertainties within the Pahute Mesa–Oasis Valley hydrostratigraphic model. In particular, the well was intended to help define the structural position and hydraulic parameters for volcanic aquifers potentially down-gradient from historic underground nuclear tests on Pahute Mesa. It may also be used as a long-term monitoring well.

  9. Completion Report for Well ER-EC-15 Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    SciTech Connect (OSTI)

    NSTec Environmental Management

    2011-05-31T23:59:59.000Z

    Well ER-EC-15 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada National Security Site (formerly known as the Nevada Test Site), Nye County, Nevada. The well was drilled in October and November 2010, as part of the Pahute Mesa Phase II drilling program. The primary purpose of the well was to provide detailed hydrogeologic information in the Tertiary volcanic section in the area between Pahute Mesa and the Timber Mountain caldera complex that will help address uncertainties within the Pahute Mesa–Oasis Valley hydrostratigraphic model. In particular, the well was intended to help define the structural position and hydraulic parameters of volcanic aquifers potentially down-gradient from underground nuclear tests on Pahute Mesa. It may also be used as a long-term monitoring well.

  10. Completion Report for Well ER-EC-13 Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    SciTech Connect (OSTI)

    NSTec Environmental Management

    2011-05-31T23:59:59.000Z

    Well ER-EC-13 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, in support of the Nevada Environmental Restoration Project at the Nevada National Security Site (formerly Nevada Test Site), Nye County, Nevada. The well was drilled in October 2010 as part of the Pahute Mesa Phase II drilling program. A main objective was to provide detailed hydrogeologic information for the Fortymile Canyon composite unit hydrostratigraphic unit in the Timber Mountain moat area, within the Timber Mountain caldera complex, that will help address uncertainties within the Pahute Mesa–Oasis Valley hydrostratigraphic framework model. This well may also be used as a long-term monitoring well.

  11. Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo

    SciTech Connect (OSTI)

    Herrmann, Julia E.; Heale, Jason; Bieraugel, Mike; Ramos, Meg [Drug Safety Evaluation, Allergan Inc., 2525 Dupont Dr, Irvine, CA 92612 (United States); Fisher, Robyn L. [Vitron Inc., Tucson, AZ (United States); Vickers, Alison E.M., E-mail: vickers_alison@allergan.com [Drug Safety Evaluation, Allergan Inc., 2525 Dupont Dr, Irvine, CA 92612 (United States)

    2014-01-15T23:59:59.000Z

    Human response to isoproterenol induced cardiac injury was evaluated by gene and protein pathway changes in human heart slices, and compared to rat heart slices and rat heart in vivo. Isoproterenol (10 and 100 ?M) altered human and rat heart slice markers of oxidative stress (ATP and GSH) at 24 h. In this in vivo rat study (0.5 mg/kg), serum troponin concentrations increased with lesion severity, minimal to mild necrosis at 24 and 48 h. In the rat and the human heart, isoproterenol altered pathways for apoptosis/necrosis, stress/energy, inflammation, and remodeling/fibrosis. The rat and human heart slices were in an apoptotic phase, while the in vivo rat heart exhibited necrosis histologically and further progression of tissue remodeling. In human heart slices genes for several heat shock 70 kD members were altered, indicative of stress to mitigate apoptosis. The stress response included alterations in energy utilization, fatty acid processing, and the up-regulation of inducible nitric oxide synthase, a marker of increased oxidative stress in both species. Inflammation markers linked with remodeling included IL-1?, Il-1?, IL-6 and TNF? in both species. Tissue remodeling changes in both species included increases in the TIMP proteins, inhibitors of matrix degradation, the gene/protein of IL-4 linked with cardiac fibrosis, and the gene Ccl7 a chemokine that induces collagen synthesis, and Reg3b a growth factor for cardiac repair. This study demonstrates that the initial human heart slice response to isoproterenol cardiac injury results in apoptosis, stress/energy status, inflammation and tissue remodeling at concentrations similar to that in rat heart slices. - Highlights: • Human response to isoproterenol induced cardiac injury evaluated in heart slices. • Isoproterenol altered apoptosis, energy, inflammation and remodeling pathways. • Human model verified by comparison to rat heart slices and rat heart in vivo. • Human and rat respond to isoproterenol at similar concentrations in vitro.

  12. A DELAYED NONLINEAR PBPK MODEL FOR GENISTEIN DOSIMETRY IN RATS

    E-Print Network [OSTI]

    A DELAYED NONLINEAR PBPK MODEL FOR GENISTEIN DOSIMETRY IN RATS #3; MICHAEL G. ZAGER y , HIEN T on laboratory animals and human volunteers [4], and critical literature reviews [32]. Phytoestrogens, a class endocrine-related e#11;ects such as reduced birth weight in rats and humans. In its conjugated form

  13. Measurement of Regional Lung Function in Rats Using Hyperpolarized 3

    E-Print Network [OSTI]

    Measurement of Regional Lung Function in Rats Using Hyperpolarized 3 Helium Dynamic MRI Ben T. Chen,* Anja C.S. Brau, and G. Allan Johnson Dynamic regional lung function was investigated in rats using by a constant flow ventila- tor. Based on regional differences in the behavior of inspired air, the lung

  14. Electrical resistivity and thermopower of single-crystal RNi2B2C (R=Dy, Ho, Er, Tm) magnetic superconductors

    E-Print Network [OSTI]

    Bhatnagar, AK; Rathnayaka, KDD; Naugle, Donald G.; Canfield, PC.

    1997-01-01T23:59:59.000Z

    The in-plane resistivity rho and thermopower S of single crystal RNi2B2C (R=Dy, Ho, Er, Tm) has been measured from 4 to 300 K. The resistivity is linear in temperature from about 100 to 300 K, but the low-temperature dependence goes as T-p With p...

  15. Poisoning Incidence in Wisconsin: Does Age Ma2er? Thomas Leschke, BA; Clare Guse, MS; Amy Schlo2hauer, MPH; Peter Layde, MD, MSc IntroducEon

    E-Print Network [OSTI]

    Poisoning Incidence in Wisconsin: Does Age Ma2er? Thomas Leschke, BA; Clare groups for both intenEonal opioid and non-opioid poisonings Opioid range: 6 and ICD -10 codes were used to divide poisoning incidents by agent (opioid vs

  16. 12me Colloque National AIP PRIMECA Le Mont Dore -29 Mars-1er avril 2011 DE SYSML A MODELICA : AIDE A LA FORMALISATION DE

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    12ème Colloque National AIP PRIMECA Le Mont Dore - 29 Mars- 1er avril 2011 1 DE SYSML A MODELICA lequel l'approche de l'ingénierie système basée sur les modèles est utilisée. SysML et Modelica sont les graphique et visuelle alors que Modelica est un langage textuel destiné à la simulation des modèles. Dans le

  17. FLGESKJEMA FOR SKERE TIL PPU TEACH FIRST NORWAY Dersom du har utdanning som ikke er tatt ved UiO, m du skrive ut dette skjemaet og

    E-Print Network [OSTI]

    Løw, Erik

    F�LGESKJEMA FOR S�KERE TIL PPU TEACH FIRST NORWAY Dersom du har utdanning som ikke er tatt ved Ui søke PPU Teach First Norway i Søknadsweb. Ditt navn: Fødselsnr: Jeg har søkt om fagdidaktikk i

  18. Role of estrogen receptor alpha (ER alpha) insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells 

    E-Print Network [OSTI]

    Zhang, Shu

    2009-05-15T23:59:59.000Z

    Insulin-like growth factor-I (IGF-I) is a mitogenic polypeptide that induces proliferation and activation of kinase pathways in MCF-7 breast cancer cells. The role of estrogen receptor ? (ER?) in mediating responses induced by IGF-I was investigated...

  19. Final Report for Grant DE-FG02-91ER40690 for the period 12/1/2010 to 4/30/2014

    SciTech Connect (OSTI)

    Kass, R.; Durkin, L.; Hill, C.; Braaten, E.; Mathur, S.; Raby, S.; Shigemitsu, J.; Gan, K.; Kagan, H.; Hughes, R.; Winer, B.; Honscheid, K.

    2014-07-22T23:59:59.000Z

    This is the #12;final report for The Ohio State University high energy physics grant DE-FG02- 91ER40690. The activities of the various Tasks are briefy summarized over the previous grant period. The support from the Department of Energy is greatly appreciated.

  20. The Lujan Center is a national user facility funded by Basic Energy Sciences of the Department of Energy which o ers capability for basic and applied neutron scattering

    E-Print Network [OSTI]

    of Energy which o ers capability for basic and applied neutron scattering relevant to national security are the domain of the low-Q scattering intrument, LQD. These well-established neutron techniques probe long Matter, Local Structure, and Nanomaterials The Lujan Neutron Scattering Center encompasses a set

  1. Butz, T. and von Stryk, O.: Modelling and Simulation of ER and MR Fluid Dampers 1 ZAMM Z. angew. Math. Mech. 78 (1998) 0, 122

    E-Print Network [OSTI]

    Stryk, Oskar von

    Butz, T. and von Stryk, O.: Modelling and Simulation of ER and MR Fluid Dampers 1 ZAMM · Z. angew. Math. Mech. 78 (1998) 0, 1­22 Butz, T.; von Stryk, O. Modelling and Simulation of Electro, phenomenological models, numerical simulation, pas- sive suspension MSC (1991): 65C20, 76A05 1 Introduction Electro

  2. Guided wave absorption and uorescence in epitaxial Er:BaTiO3 on MgO D.M. Gilla,*, G.M. Fordb

    E-Print Network [OSTI]

    Ho, Seng-Tiong

    . Keywords: Er:BaTiO3; Fluorescence; Luminescence 1. Introduction The development of low-cost composite waveguides fabricated in erbium-doped thin-®lm epitaxial BaTiO3. Luminescence transient measurements indicate strategies toward the realization of this type of opto-electronic circuit. Proposed designs of hybrid opto

  3. Impacts of the Norway Rat on the auklet breeding colony at Sirius Point, Kiska

    E-Print Network [OSTI]

    Jones, Ian L.

    Impacts of the Norway Rat on the auklet breeding colony at Sirius Point, Kiska Island, Alaska-3239 FAX: (709) 737-3018 e-mail: x19hlm@mun.ca #12;Major and Jones Impacts of the Norway Rat... 2 Fresh rat during World War II (Atkinson, 1985). It is believed that the Norway Rat (Rattus norvegicus

  4. Differential Expression of Cyclic Nucleotide Phosphodiesterases 4 in Developing Rat Lung Running Title: PDE4 in developing rat lung

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Differential Expression of Cyclic Nucleotide Phosphodiesterases 4 in Developing Rat Lung Running Title: PDE4 in developing rat lung Emmanuel Lopez 1,2,3,4 , Pierre-Henri Jarreau 1,2,3,4 , Elodie Zana 1 Dynamics 239, 9 (2010) 2470-8" DOI : 10.1002/dvdy.22374 #12;2 Abstract During the perinatal period, lungs

  5. Toxicologic and biochemical effects of extracts from Karwinskia humboldtiana on the albino rat

    E-Print Network [OSTI]

    Wheeler, Michael Hugh

    1970-01-01T23:59:59.000Z

    Oral doses of coyotillo plant extract (Pe-1) given to rats of Group I-A. 12 Weight changes observed in rats following oral administration of coyotillo plant extract (Pe-l). Microscopic lesions observed in rats following oral administration... of coyotillo plant extract (Pe-l). Weight changes observed in rats following chronic oral administration of coyotillo plant extract (Cn-l). 37 Weight changes observed in rats following acute oral administration of coyotillo plant extract (Ch-l). 38...

  6. Acceleration of wound healing in young and aged rats 

    E-Print Network [OSTI]

    Maxwell, Bryan Douglas

    1996-01-01T23:59:59.000Z

    1. The effect of ACM on wound healing in young rats. . Page 15 2. The effect of ACM on wound healing in old, ad-lib rats . . . . . . . 17 3. The effect of ACM on wound healing in old, caloric-restricted rats . . . 4. The effect of old and young... group (AL) had been fed a laboratory diet ad libitum during their lifetime. The other group (CR) had been maintained on a calorie-restricted diet at a level of 60% of the food intake of the ad libitum-fed group. This decrease in caloric intake resulted...

  7. Completion Report for Well ER-20-7: Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    SciTech Connect (OSTI)

    NSTec Environmental Restoration

    2010-04-28T23:59:59.000Z

    Well ER-20-7 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. The well was drilled in June 2009 as part of the Pahute Mesa Phase II drilling program. The primary purpose of the well was to further investigate migration of radionuclides from the nearby, up-gradient TYBO and BENHAM underground nuclear tests, which originally was discovered at Well Cluster ER-20-5. This well also provided detailed hydrogeologic information in the Tertiary volcanic section that will reduce uncertainties within the Pahute Mesa-Oasis Valley hydrostratigraphic framework model. The main 44.45-centimeter hole was drilled to a depth of 681.8 meters and cased with 33.97-centimeter casing to 671.7 meters. The hole diameter was then decreased to 31.12 centimeters, and the well was drilled to total depth of 894.9 meters. The completion string, set to the depth of 890.0 meters, consists of 14.13-centimeter stainless-steel casing hanging from 19.37-centimeter carbon-steel casing. The 14.13-centimeter stainless-steel casing has one continuous slotted interval open to the Topopah Spring aquifer. Data collected during and shortly after hole construction include composite drill cuttings samples collected every 3.0 meters, sidewall core samples from 20 depth intervals, various geophysical logs, water quality (primarily tritium) measurements, and water level measurements. The well penetrated 894.9 meters of Tertiary volcanic rock, including two saturated welded-tuff aquifers. A fluid level measurement was obtained during open-hole geophysical well logging for the upper, Tiva Canyon, aquifer at the depth of 615.7 meters on June 19, 2009. The fluid level measured in the open hole on June 27, 2009,after the total depth was reached and the upper aquifer was cased off, was also at the depth of 615.7 meters. Preliminary field measurements indicated 1.5 to 4.5 million picocuries per liter of tritium in the Tiva Canyon aquifer and 20 to 61 million picocuries per liter in the underlying Topopah Spring aquifer.

  8. Mid-infrared frequency comb spanning an octave based on an Er fiber laser and difference-frequency generation

    E-Print Network [OSTI]

    Fritz Keilmann; Sergiu Amarie

    2012-03-22T23:59:59.000Z

    We describe a coherent mid-infrared continuum source with 700 cm-1 usable bandwidth, readily tuned within 600 - 2500 cm-1 (4 - 17 \\mum) and thus covering much of the infrared "fingerprint" molecular vibration region. It is based on nonlinear frequency conversion in GaSe using a compact commercial 100-fs-pulsed Er fiber laser system providing two amplified near-infrared beams, one of them broadened by a nonlinear optical fiber. The resulting collimated mid-infrared continuum beam of 1 mW quasi-cw power represents a coherent infrared frequency comb with zero carrier-envelope phase, containing about 500,000 modes that are exact multiples of the pulse repetition rate of 40 MHz. The beam's diffraction-limited performance enables long-distance spectroscopic probing as well as maximal focusability for classical and ultraresolving near-field microscopies. Applications are foreseen also in studies of transient chemical phenomena even at ultrafast pump-probe scale, and in high-resolution gas spectroscopy for e.g. breath analysis.

  9. Near infrared and upconversion luminescence behaviour of Er{sup 3+}/Yb{sup 3+} codoped boro-tellurite glasses

    SciTech Connect (OSTI)

    Maheshvaran, K. [Department of Physics, Gandhigram Rural Institute - Deemed University, Gandhigram - 624302, India and Department of Physics, K.S. Rangasamy College of Technology, Trichengode - 637215 (India); Arunkumar, S., E-mail: mari-ram2000@yahoo.com; Vijayakumar, R., E-mail: mari-ram2000@yahoo.com; Marimuthu, K., E-mail: mari-ram2000@yahoo.com [Department of Physics, Gandhigram Rural Institute ? Deemed University, Gandhigram - 624302 (India)

    2014-04-24T23:59:59.000Z

    The broadband NIR and upconversion luminescence behavior in a new series of Er{sup 3+}/Yb{sup 3+} codoped TeO{sub 2}-B{sub 2}O{sub 3}-SrO-BaO-Li{sub 2}O-LiF glasses have been studied exciting at a wavelength of 980 nm using semiconductor laser. A broadband emission is observed from 1450 to 1650 nm with a full width at half maximum (FWHM) around 165 nm in 0.5wt% Yb{sup 3+} ion content E0.5YLTB glass. The radiative parameters such as transition probability (A), stimulated emission cross-section (?{sup E}), experimental and calculated branching ratios (?{sub R}), optical gain width (?{sub p}×FWHM) and radiative lifetime (?{sub cal}) have been calculated for the {sup 4}I{sub 13/2}?{sup 4}I{sub 15/2} NIR emission. Upconversion luminescence spectra of the prepared glasses have been studied and the ESA and ET processes have also been discussed and reported.

  10. Completion Report for Well ER-EC-11 Corrective Action Units 101 and 102: Central and Western Pahute Mesa

    SciTech Connect (OSTI)

    NSTec Environmental Management

    2010-12-01T23:59:59.000Z

    Well ER-EC-11 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, in support of the Nevada Environmental Restoration Project at the Nevada National Security Site (formerly Nevada Test Site), Nye County, Nevada. The well was drilled in September and October 2009 as part of the Pahute Mesa Phase II drilling program. A main objective was to investigate radionuclide migration down-gradient from Well Cluster ER-20-5 and Well ER-20-7 and across the northern Timber Mountain moat structural zone into the area referred to as the Bench, between Pahute Mesa and the Timber Mountain caldera complex. A secondary purpose of the well was to provide detailed hydrogeologic information for the shallow- to intermediate-depth Tertiary volcanic section in the Bench area. This well also provided detailed hydrogeologic information in the Tertiary volcanic section to reduce uncertainties within the Pahute Mesa-Oasis Valley hydrostratigraphic framework model (Bechtel Nevada, 2002). The main 52.1-centimeter hole was drilled to a depth of 507.5 meters and then opened to a diameter of 66.0 centimeters. It was cased with 50.8-centimeter casing to 504.9 meters. The hole diameter was then decreased to 47.0 centimeters, and drilling continued to a total depth of 979.3 meters. It was then cased with 34.0-centimeter casing set at 965.5 meters. The hole diameter was then decreased to 31.1 centimeters and the borehole was drilled to a total depth of 1,264.3 meters. The completion casing string, set to the depth of 1,262.5 meters, consists of 19.4-centimeter stainless-steel casing hanging from 19.4-centimeter carbon-steel casing. The stainless-steel casing has two slotted intervals open to the Tiva Canyon and Topopah Spring aquifers. Four piezometer strings were installed in Well ER-EC-11. A string of carbon-steel 6.0-centimeter tubing with one slotted interval was inserted outside the 50.8-centimeter casing, within the 66.0-centimeter borehole for access to the Timber Mountain aquifer, and landed at 475.3 meters. A second string of 6.0-centimeter tubing with one slotted interval was inserted outside the 34.0-centimeter casing, within the 47.0-centimeter borehole for access to the Benham aquifer, and landed at 911.7 meters. A third piezometer string consists of 7.3-centimeter stainless-steel tubing that hangs from 6.0-centimeter carbon-steel tubing via a crossover sub. This string was landed at 1,029.5 meters to monitor the Tiva Canyon aquifer. The deepest string of 7.3-centimeter tubing was landed at 1,247.8 meters to monitor the Topopah Spring aquifer. Data collected during and shortly after hole construction include composite drill cuttings samples collected every 3.0 meters, 67 percussion gun and rotary sidewall core samples, various geophysical logs, fluid samples (for groundwater chemistry analysis and tritium measurements), and water-level measurements. The well penetrated 1,264.3 meters of Tertiary volcanic rock, including three saturated welded-tuff aquifers and one saturated lava-flow aquifer. A water level was measured in the Timber Mountain aquifer at 449.6 meters, during open-hole geophysical logging on September 20, 2009. The fluid level measured after the total depth was reached and the upper aquifer was cased off was 450.0 meters when measured in the open borehole on October 17, 2009. Measurements on samples taken from the undeveloped well indicated that tritium levels averaging approximately 12,430 picocuries per liter (less than Safe Drinking Water Act levels) were encountered within the Benham aquifer. Tritium was below the minimum detectable activity concentration for samples collected from the Tiva Canyon aquifer and the Topopah Spring aquifer.

  11. awake rats achieving: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Studies of Brain Function in Awake Rats CiteSeer Summary: Positron emission tomography (PET) is a non-invasive molecular imaging technique using positron-emitting radioisotopes to...

  12. adult rats rattus: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 IMPACTS OF INTRODUCED NORWAY RATS (RATTUS NORVEGICUS) ON LEAST AUKLETS (AETHIA PUSILLA) BREEDING AT KISKA ISLAND,...

  13. Thermal conductivity of Er{sup +3}:Y{sub 2}O{sub 3} films grown by atomic layer deposition

    SciTech Connect (OSTI)

    Raeisi Fard, Hafez; Hess, Andrew; Pashayi, Kamyar; Borca-Tasciuc, Theodorian, E-mail: borcat@rpi.edu [Mechanical, Aerospace and Nuclear Engineering Department, Rensselaer Polytechnic Institute, Troy, New York 12180 (United States)] [Mechanical, Aerospace and Nuclear Engineering Department, Rensselaer Polytechnic Institute, Troy, New York 12180 (United States); Becker, Nicholas; Proslier, Thomas; Pellin, Michael [Material Sciences Division, Argonne National Laboratory 9700 S. Cass Avenue, Lemont, Illinois 60439 (United States)] [Material Sciences Division, Argonne National Laboratory 9700 S. Cass Avenue, Lemont, Illinois 60439 (United States)

    2013-11-04T23:59:59.000Z

    Cross-plane thermal conductivity of 800, 458, and 110?nm erbium-doped crystalline yttria (Er{sup +3}:Y{sub 2}O{sub 3}) films deposited via atomic layer deposition was measured using the 3? method at room temperature. Thermal conductivity results show 16-fold increase in thermal conductivity from 0.49?W m{sup ?1}K{sup ?1} to 8?W m{sup ?1}K{sup ?1} upon post deposition annealing, partially due to the suppression of the number of the -OH/H{sub 2}O bonds in the films after annealing. Thermal conductivity of the annealed film was ?70% lower than undoped bulk single crystal yttria. The cumulative interface thermal resistivity of substrate-Er{sup +3}:Y{sub 2}O{sub 3}-metal heater was determined to be ?2.5?×?10{sup ?8} m{sup 2} K/W.

  14. Temperature of broadband anti-Stokes white emission in LiYbP{sub 4}O{sub 12}: Er nanocrystals

    SciTech Connect (OSTI)

    Marciniak, L., E-mail: l.marciniak@int.pan.wroc.pl; Strek, W.; Hreniak, D. [Institute of Low Temperature and Structure Research, Polish Academy of Sciences, 50-422 Wroc?aw (Poland); Guyot, Y. [Institute Light Matter (ILM), UMR5306 CNRS-University Lyon1, University of Lyon, 69622 Villeurbanne (France)

    2014-10-27T23:59:59.000Z

    The up-conversion emission of LiYb{sub 0.99}Er{sub 0.01}P{sub 4}O{sub 12} nanocrystals was investigated in vacuum upon the focused beam of infrared laser excitation. The intense white broad band emission was observed above the threshold power of 800 mW. An increase of excitation power results in enhancement of temperature of emitting nanocrystals. The temperature of nanocrystals was determined following the thermally equilibrated f-f emission transitions of Er{sup 3+} ions. The highest measured temperature of white emission was determined to be about 900?K. It is concluded that the black body radiation is not responsible for the white broad band emission.

  15. AMPA-receptor mediated plasticity within the rat spinal cord

    E-Print Network [OSTI]

    Hoy, Kevin Corcoran

    2009-05-15T23:59:59.000Z

    AMPA-RECEPTOR MEDIATED PLASTICITY WITHIN THE RAT SPINAL CORD A Thesis by KEVIN CORCORAN HOY JR. Submited to the Ofice of Graduate Studies of Texas A&M University in partial fulfilment of the requirements... for the degre of MASTER OF SCIENCE August 2008 Major Subject: Psychology AMPA-RECEPTOR MEDIATED PLASTICITY WITHIN THE RAT SPINAL CORD A Thesis by KEVIN CORCORAN HOY JR. Submited to the Ofice of Graduate...

  16. Distribution of ochratoxin A in the pregnant rat

    E-Print Network [OSTI]

    Ballinger, Michael Brent

    1983-01-01T23:59:59.000Z

    . . . APPENDIX 1. SAFETY PROCEDURES. APPENDIX 2. BIOLOGICAL OXIDIZER PROCEDURES. . . APPENDIX 3. LIQUID SCINTILLATION COUNTING. . . . APPENDIX 4. PHARMACOKINETIC CALCULATIONS. . . . . VITA. 1V V1 V11 V111 3 4 12 26 27 27 27 28 29 33 35 54 57... 66 68 71 73 74 LIST OF TABLES Table Page 1 Pharmacokinetic parameters estimated from the serum radioactivity derived from 3H-ochratoxin A in pregnant rats. . 2 Excretion of 3H radioactivity by pregnant rats. . 38 39 3 Distribution...

  17. Arginine and Conjugated Linoleic Acid Reduce Fat Mass in Rats

    E-Print Network [OSTI]

    Nall, Jennifer L.

    2010-10-12T23:59:59.000Z

    ARGININE AND CONJUGATED LINOLEIC ACID REDUCE FAT MASS IN RATS A Thesis by JENNIFER LYNN NALL Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree... of MASTER OF SCIENCE May 2008 Major Subject: Nutrition ARGININE AND CONJUGATED LINOLEIC ACID REDUCE FAT MASS IN RATS A Thesis by JENNIFER LYNN NALL Submitted to the Office of Graduate Studies Texas A...

  18. Emission intensity in the visible and IR spectral ranges from Si-based structures formed by direct bonding with simultaneous doping with erbium (Er) and europium (Eu)

    SciTech Connect (OSTI)

    Mezdrogina, M. M., E-mail: margaret.m@mail.ioffe.ru; Kostina, L. S.; Beliakova, E. I.; Kuzmin, R. V. [Russian Academy of Sciences, Ioffe Physical-Technical Institute (Russian Federation)] [Russian Academy of Sciences, Ioffe Physical-Technical Institute (Russian Federation)

    2013-09-15T23:59:59.000Z

    The photo- and electroluminescence spectra of silicon-based structures formed by direct bonding with simultaneous doping with rare-earth metals are studied. It is shown that emission in the visible and IR spectral ranges can be obtained from n-Si:Er/p-Si and n-Si:Eu/p-Si structures fabricated by the method suggested in the study. The results obtained make this method promising for the fabrication of optoelectronic devices.

  19. Neuroendocrine effects of acute nickel chloride administration in rats

    SciTech Connect (OSTI)

    Clemons, G.K.; Garcia, J.F.

    1981-01-01T23:59:59.000Z

    An sc injection of nickel chloride (20 and 10 mg/kg) led to a profound and consistent increase of circulating prolactin (PRL) levels after 1 day and lasted for 4 days (p < 0.001) in male rats. Increases in insulin levels occurred 1 and 2 days postinjection. The nickel-induced PRL rise could be abolished by a simultaneous administration of 2-bromo-..cap alpha..-ergocryptine (CB 154). In vitro incubation of pituitaries from rats that received 20 mg/kg of nickel chloride 48 hr prior to sacrifice released more PRL into the culture medium, as well as contained more PRL in the final tissue than did the pituitaries from control animals. The hypothalamic extracts (HE) obtained from hypothalami of nickel-injected rats were tested also in vitro on normal rat pituitaries and the results showed that the HE from such rats released more PRL and therefore had less prolactin-inhibiting factor (PIF) than the HE obtained from control rats. The results show that nickel chloride has effects on the endocrine system that (a) last considerably longer than previously reported, (b) are mediated through the neuroendocrine system, and (c) instead of specifically inhibiting PRL secretion from the pituitary promote high circulating PRL levels lasting from 1 to 4 days.

  20. Energy transfer characteristics of silicate glass doped with Er{sup 3+}, Tm{sup 3+}, and Ho{sup 3+} for ?2 ?m emission

    SciTech Connect (OSTI)

    Li, Ming; Liu, Xueqiang [Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China) [Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China); Graduate School of Chinese Academy of Sciences, Beijing 100039 (China); Guo, Yanyan [College of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022 (China)] [College of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022 (China); Hu, Lili [Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China)] [Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China); Zhang, Junjie [College of Materials Science and Engineering, China Jiliang University, Hangzhou 310 018 (China)] [College of Materials Science and Engineering, China Jiliang University, Hangzhou 310 018 (China)

    2013-12-28T23:59:59.000Z

    A Er{sup 3+}/Tm{sup 3+}/Ho{sup 3+} tri-doped silicate glass with good thermal stability is prepared by melt-quenching method. Efficient ?2 ?m emission is observed under 808 nm laser excitation. It is found that the 2.0 ?m emission of Ho{sup 3+} can be enhanced under the excitation at 808 nm by incorporating Er{sup 3+} and Tm{sup 3+}. Based on the measurement of absorption spectra, the Judd–Ofelt intensity parameters, radiation emission probability, and branching ratio are calculated to evaluate the spectroscopic properties simultaneously. The maximum value of emission cross section of Ho{sup 3+} is 3.54 × 10{sup ?21} cm{sup 2} at 2008 nm. Additionally, the phonon assistance and the micro-parameters in the energy transfer process are quantitatively analyzed by using Dexter model. The energy transfer coefficient from Tm{sup 3+} to Ho{sup 3+} can reach as high as 21.44 × 10{sup ?40} cm{sup 6}/s, respectively. The emission property together with good thermal property indicates that Er{sup 3+}/Tm{sup 3+}/Ho{sup 3+} tri-doped silicate glass is a potential kind of laser glass for efficient 2 ?m laser.

  1. NaYF{sub 4}:Er,Yb/Bi{sub 2}MoO{sub 6} core/shell nanocomposite: A highly efficient visible-light-driven photocatalyst utilizing upconversion

    SciTech Connect (OSTI)

    Sun, Yuanyuan; Wang, Wenzhong, E-mail: wzwang@mail.sic.ac.cn; Sun, Songmei; Zhang, Ling

    2014-04-01T23:59:59.000Z

    Highlights: • Design and synthesis of NaYF{sub 4}:Er,Yb/Bi{sub 2}MoO{sub 6} based on upconversion. • NaYF{sub 4}:Er,Yb/Bi{sub 2}MoO{sub 6} nanocomposite was prepared for the first time. • Core–shell structure benefits the properties. • Upconversion contributed to the enhanced photocatalytic activity. • Helps to understand the functionality of new type photocatalysts. - Abstract: NaYF{sub 4}:Er,Yb/Bi{sub 2}MoO{sub 6} core/shell nanocomposite was designed and prepared for the first time based on upconversion. The products were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), high resolution TEM (HRTEM), energy dispersive X-ray spectroscopy (EDS) and diffuse reflectance spectra (DRS). The results revealed that the as-synthesized NaYF{sub 4}:Er,Yb/Bi{sub 2}MoO{sub 6} consisted of spheres with a core diameter of about 26 nm and a shell diameter of around 6 nm. The core was upconversion illuminant NaYF{sub 4}:Er,Yb and the shell was Bi{sub 2}MoO{sub 6} around the core, which was confirmed by EDS. The NaYF{sub 4}:Er,Yb/Bi{sub 2}MoO{sub 6} exhibited higher photocatalytic activity for the photodecomposition of Rhodamine B (RhB) under the irradiation of Xe lamp and green light emitting diode (g-LED). The mechanism of the high photocatalytic activity was discussed by photoluminescence spectra (PL), which is mainly attributed to upconversion of NaYF{sub 4}:Er,Yb in the NaYF{sub 4}:Er,Yb/Bi{sub 2}MoO{sub 6} nanocomposite and the core–shell structure.

  2. Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes

    SciTech Connect (OSTI)

    Nadanaciva, Sashi [Compound Safety Prediction, Worldwide Medicinal Chemistry, Pfizer, Inc., Groton, CT 06340 (United States); Aleo, Michael D. [Drug Safety Research and Development, Pfizer Inc., Groton, CT 06340 (United States); Strock, Christopher J. [Cyprotex US, Watertown, MA 02472 (United States); Stedman, Donald B. [Drug Safety Research and Development, Pfizer Inc., Groton, CT 06340 (United States); Wang, Huijun [Computational Sciences, Pfizer Inc., Groton, CT 06340 (United States); Will, Yvonne, E-mail: yvonne.will@pfizer.com [Compound Safety Prediction, Worldwide Medicinal Chemistry, Pfizer, Inc., Groton, CT 06340 (United States)

    2013-10-15T23:59:59.000Z

    To reduce costly late-stage compound attrition, there has been an increased focus on assessing compounds in in vitro assays that predict attributes of human safety liabilities, before preclinical in vivo studies are done. Relevant questions when choosing a panel of assays for predicting toxicity are (a) whether there is general concordance in the data among the assays, and (b) whether, in a retrospective analysis, the rank order of toxicity of compounds in the assays correlates with the known safety profile of the drugs in humans. The aim of our study was to answer these questions using nonsteroidal anti-inflammatory drugs (NSAIDs) as a test set since NSAIDs are generally associated with gastrointestinal injury, hepatotoxicity, and/or cardiovascular risk, with mitochondrial impairment and endoplasmic reticulum stress being possible contributing factors. Eleven NSAIDs, flufenamic acid, tolfenamic acid, mefenamic acid, diclofenac, meloxicam, sudoxicam, piroxicam, diflunisal, acetylsalicylic acid, nimesulide, and sulindac (and its two metabolites, sulindac sulfide and sulindac sulfone), were tested for their effects on (a) the respiration of rat liver mitochondria, (b) a panel of mechanistic endpoints in rat hepatocytes, and (c) the viability and organ morphology of zebrafish. We show good concordance for distinguishing among/between NSAID chemical classes in the observations among the three approaches. Furthermore, the assays were complementary and able to correctly identify “toxic” and “non-toxic” drugs in accordance with their human safety profile, with emphasis on hepatic and gastrointestinal safety. We recommend implementing our multi-assay approach in the drug discovery process to reduce compound attrition. - Highlights: • NSAIDS cause liver and GI toxicity. • Mitochondrial uncoupling contributes to NSAID liver toxicity. • ER stress is a mechanism that contributes to liver toxicity. • Zebrafish and cell based assays are complimentary.

  3. Systemic toxicity of dermally applied crude oils in rats

    SciTech Connect (OSTI)

    Feuston, M.H.; Mackerer, C.R.; Schreiner, C.A.; Hamilton, C.E. [Stonybrook Labs., Inc., Princeton, NJ (United States)] [Stonybrook Labs., Inc., Princeton, NJ (United States)

    1997-12-31T23:59:59.000Z

    Two crude oils, differing in viscosity (V) and nitrogen (N) and sulfur (S) content, were evaluated for systemic toxicity, In the Crude I (low V, low N, low S) study, the material was applied to the clipped backs of rats at dose levels of 0, 30, 125, and 500 mg/kg. In the Crude II (high V, high N, moderate S) study, the oil was applied similarly at the same dose levels. The crude oils were applied for 13 wk, 5 d/wk. Exposure sites were not occluded. Mean body weight gain (wk 1-14) was significantly reduced in male rats exposed to Crude II; body weight gain of all other animals was not adversely affected by treatment. An increase in absolute (A) and relative (R) liver weights and a decrease in A and R thymus weights were observed in male and female rats exposed to Crude II at 500 mg/kg; only liver weights (A and R) were adversely affected in male and female rats exposed to Crude I. In general, there was no consistent pattern of toxicity for serum chemistry endpoints; however, more parameters were adversely affected in Crude II-exposed female rats than in the other exposed groups. A consistent pattern of toxicity for hematology endpoints was observed among male rats exposed to Crude I and male and female rats exposed to Crude II. Parameters affected included: Crudes I and II, red blood cell count, hemoglobin, and hematocrit, Crude II, platelet count. Microscopic evaluation of tissues revealed the following treatment-related findings: Crude I, treated skin, thymus, and thyroid; Crude II, bone marrow, treated skin, thymus, and thyroid. The LOEL (lowest observable effect level) for skin irritation and systemic toxicity (based on marginal effects on the thyroid) for both crude oils was 30 mg/kg; effects were more numerous and more pronounced in animals exposed to Crude II. Systemic effects are probably related to concentrations of polycyclic aromatic compounds (PAC) found in crude oil.

  4. Assessing the effects of Norway rats on auklet breeding success and survival at Sirius Point, Kiska

    E-Print Network [OSTI]

    Jones, Ian L.

    Assessing the effects of Norway rats on auklet breeding success and survival at Sirius Point, Kiska Introduction The presence of introduced Norway rats (Rattus norvegicus) has been implicated as a possible sightings of Norway rats at Sirius Point Colony during the late 1980s and early 1990s. Furthermore

  5. Marine Ornithology 41: 4148 (2013) Bond et al.: Crested Auklet survival with Norway Rats 41

    E-Print Network [OSTI]

    Jones, Ian L.

    Marine Ornithology 41: 41­48 (2013) Bond et al.: Crested Auklet survival with Norway Rats 41 in the Aleutians (Bailey 1993, Ebbert & Byrd 2002). Another introduced predator, the Norway rat Rattus norvegicus AND REPRODUCTIVE SUCCESS OF CRESTED AUKLETS AETHIA CRISTATELLA IN THE PRESENCE OF INTRODUCED NORWAY RATS RATTUS

  6. Variations in the diet of introduced Norway rats (Rattus norvegicus) inferred using stable isotope analysis

    E-Print Network [OSTI]

    Jones, Ian L.

    Variations in the diet of introduced Norway rats (Rattus norvegicus) inferred using stable isotope predators; island ecosystem conservation; stable isotope analysis; Norway rats; diet. Correspondence Heather of introduced Norway rats Rattus norvegicus has raised concerns for the fate of the large least auklet Aethia

  7. Stimulus Control of Maternal Responsiveness to Norway Rat (Rattus norvegicus) Pup Ultrasonic Vocalizations

    E-Print Network [OSTI]

    Stimulus Control of Maternal Responsiveness to Norway Rat (Rattus norvegicus) Pup Ultrasonic be considered a specialization of Norway rats and other small rodents. When removed from the nest and placed in a cool environment, infant Norway rats emit USVs. These vocalizations range from 30 to 50 k

  8. STABLE FREQUENCY RESPONSE TO VARYING STIMULUS INTENSITY IN A MODEL OF THE RAT OLFACTORY BULB

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    STABLE FREQUENCY RESPONSE TO VARYING STIMULUS INTENSITY IN A MODEL OF THE RAT OLFACTORY BULB Thomas Neurosciences et Systèmes sensoriels, CNRS UMR 5020, Lyon, France ABSTRACT In the rat olfactory bulb (OB), fast. Introduction The rat olfactory bulb (OB) is a rich and complex sensory processing system that shows stimulus

  9. Inhalation developmental toxicology studies: Gallium arsenide in mice and rats

    SciTech Connect (OSTI)

    Mast, T.J.; Greenspan, B.J.; Dill, J.A.; Stoney, K.H.; Evanoff, J.J.; Rommereim, R.L.

    1990-12-01T23:59:59.000Z

    Gallium arsenide is a crystalline compound used extensively in the semiconductor industry. Workers preparing solar cells and gallium arsenide ingots and wafers are potentially at risk from the inhalation of gallium arsenide dust. The potential for gallium arsenide to cause developmental toxicity was assessed in Sprague- Dawley rats and CD-1 (Swiss) mice exposed to 0, 10, 37, or 75 mg/m{sup 3} gallium arsenide, 6 h/day, 7 days/week. Each of the four treatment groups consisted of 10 virgin females (for comparison), and {approx}30 positively mated rats or {approx}24 positively mated mice. Mice were exposed on 4--17 days of gestation (dg), and rats on 4--19 dg. The day of plug or sperm detection was designated as 0 dg. Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice (rats, 20 dg; mice, 18 dg). Implants were enumerated and their status recorded. Live fetuses were sexed and examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. Gallium and arsenic concentrations were determined in the maternal blood and uterine contents of the rats (3/group) at 7, 14, and 20 dg. 37 refs., 11 figs., 30 tabs.

  10. Inhalation developmental toxicology studies: Acetonitrile in rats. Final report

    SciTech Connect (OSTI)

    Mast, T.J.; Weigel, R.J.; Westerberg, R.B.; Boyd, P.J.; Hayden, B.K.; Evanoff, J.J.; Rommereim, R.L.

    1994-02-01T23:59:59.000Z

    The potential for acetonitrile to cause developmental toxicity was assessed in Sprague-Dawley rats exposed to 0, 100, 400, or 1200 ppM acetonitrile, 6 hours/day, 7 days/week. Exposure of rats to these concentrations of acetonitrile resulted in mortality in the 1200 ppM group (2/33 pregnant females; 1/10 non-pregnant females). However, there were no treatment-related effects upon body weights or reproduction indices at any exposure level, nor was there a significant increase in the incidence of fetal malformations or variations. The only effect observed in the fetuses was a slight, but not statiscally significant, exposure-correlated increase in the incidence of supernumerary ribs. Determination of acetonitrile and cyanide concentrations in maternal rat blood showed that acetonitrile concentration in the blood increased with exposure concentration for all exposed maternal rats. Detectable amounts of cyanide in the blood were found only in the rats exposed to 1200 ppM acetonitrile ({approximately}2 {mu}g cyanide/g of blood).

  11. DJS CLAIM ER

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power Administration wouldDECOMPOSITION OF CALCIUM SULFATE: A REVIEWThis rcportJ it c 5

  12. DOE/ER-0442

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power Administration wouldDECOMPOSITION OF CALCIUMCOSTDOENuclear1382 THE HUMAN GENOME INITIATIVE12

  13. Frequency upconversion in Er{sup 3+} doped Y{sub 2}O{sub 3} nanophosphor:Yb{sup 3+} sensitization and tailoring effect of Li{sup +} ion

    SciTech Connect (OSTI)

    Mishra, K. [Laser and Spectroscopy Laboratory, Department of Physics, Banaras Hindu University, Varanasi 221005 (India); Singh, S.K., E-mail: sunilcfsl@gmail.com [Department of Physics, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005 (India); Singh, A.K. [School of Materials Science and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005 (India); Rai, S.B., E-mail: sbrai49@yahoo.co.in [Laser and Spectroscopy Laboratory, Department of Physics, Banaras Hindu University, Varanasi 221005 (India)

    2013-10-15T23:59:59.000Z

    Graphical abstract: - Highlights: • Dual mode luminescence behavior of Er{sup 3+} in oxide phosphor. • Sensitization through Yb{sup 3+} codoping, and tailoring effect of lithium ion. • Phosphors for lighting and display applications. - Abstract: Er{sup 3+} doped Y{sub 2}O{sub 3} nanophosphor has been synthesized using solution combustion technique and further characterized for structure and optical properties. Optical properties of Er{sup 3+} ion have been studied both through frequency upconversion (UC) as well as through fluorescence (excitation, emission, and CIE co-ordinate analysis) processes. Further to enhance the UC emission of Er{sup 3+} ions, a two step process has been used. In the first step, Yb{sup 3+} ion has been co-doped, which acts as the sensitizer for Er{sup 3+} through energy transfer process. In the second step, different concentrations of Li{sup +} ions have been co-doped in the Er{sup 3+}/Yb{sup 3+}:Y{sub 2}O{sub 3} system. Fourier transform infrared analysis, and X-ray diffraction (XRD) followed by Le-Bail refinement of the XRD data reveal that the co-doping of Li{sup +} ion decreases unit cell parameter, increases the particle size, and removes the quenching centers (like OH, NO{sub x}, etc.), which all together causes a significant enhancement in UC emission. Optimum UC luminescence is attained for 5 mol% Li{sup +} doping concentration beyond which a quenching in UC emission is observed. This combined approach, i.e. Yb{sup 3+} sensitization and Li{sup +} ion tailoring simultaneously enhances the UC emission intensity of Er{sup 3+} several times in yttria matrix effectively. The strategy can be generalized in other hosts also which could help in the development of efficient photonic materials for lighting and display devices.

  14. Solution Processed MoS2-PVA Composite for Sub-Bandgap Mode-Locking of a Wideband Tunable Ultrafast Er:Fiber Laser

    E-Print Network [OSTI]

    Zhang, Meng; Howe, Richard C. T.; Woodward, Robert I.; Kelleher, Edmund J. R.; Torrisi, Felice; Hu, Guohua; Popov, Sergei V.; Taylor, J. Roy; Hasan, Tawfique

    2014-11-11T23:59:59.000Z

    with stable, picosecond pulses, tunable from 1535 nm to 1565 nm 2 Solution Processed MoS2-PVA Composite for Sub-Bandgap Mode-Locking of a Wideband Tunable Ultrafast Er:Fiber Laser Meng Zhang1, Richard C. T. Howe2, Robert I. Woodward1... ! to! relaxation! of! thermalized! electron! and!phonon! distribution! [3].! This! combination! of!properties!makes!MoS2!a!suitable!saturable!absorber!(SA)! for! ultrafast! mode+locked! pulsed! lasers,! with!the! potential! for! pulse! generation! at...

  15. The effect of fear on gregariousness and exploration in rats

    E-Print Network [OSTI]

    Anderson, Bergie Wayne

    1973-01-01T23:59:59.000Z

    ' "ms of the behavior occurring in the open field. Rats display three major behaviors in the open field; these are fear, exploration, and gregariousness. Research has shown that when a pMr of rats are placed into an open field, they display signs... them. The two variables were found to be positively correlated and significant at the 0. 05 level of con- fidence (r = . 16; df = 230). The analysis of variance of the combined fear scores, indicated a significant difference. between methods (F = 4...

  16. Temperature dependence of Er{sup 3+} ionoluminescence and photoluminescence in Gd{sub 2}O{sub 3}:Bi nanopowder

    SciTech Connect (OSTI)

    Boruc, Zuzanna, E-mail: z.boruc@stud.elka.pw.edu.pl; Fetli?ski, Bartosz; Kaczkan, Marcin; Malinowski, Micha? [Institute of Microelectronics and Optoelectronics, Warsaw University of Technology, ul. Koszykowa 75, 00-662 Warsaw (Poland); Gawlik, Grzegorz [Institute of Electronic Materials Technology, ul. Wolczynska 133, 01-919 Warsaw (Poland)

    2014-06-15T23:59:59.000Z

    Ionoluminescence (IL) and photoluminescence (PL) of trivalent erbium ions (Er{sup 3+}) in Gd{sub 2}O{sub 3} nanopowder host activated with Bi{sup 3+} ions has been studied in order to establish the link between changes in luminescent spectra and temperature of the sample material. IL measurements have been performed with H{sub 2}{sup +} 100 keV ion beam bombarding the target material for a few seconds, while PL spectra have been collected for temperatures ranging from 20?°C to 700?°C. The PL data was used as a reference in determining the temperature corresponding to IL spectra. The collected data enabled the definition of empirical formula based on the Boltzmann distribution, which allows the temperature to be determined with a maximum sensitivity of 9.7 × 10{sup ?3}?°C{sup ?1}. The analysis of the Er{sup 3+} energy level structure in terms of tendency of the system to stay in thermal equilibrium, explained different behaviors of the line intensities. This work led to the conclusion that temperature changes during ion excitation can be easily defined with separately collected PL spectra. The final result, which is empirical formula describing dependence of fluorescence intensity ratio on temperature, raises the idea of an application of method in temperature control, during processes like ion implantation and some nuclear applications.

  17. Analysis of nanostructure and nanochemistry by ASAXS: Accessing phase composition of oxyfluoride glass ceramics doped with Er{sup 3+}/Yb{sup 3+}

    SciTech Connect (OSTI)

    Haas, Sylvio; Hoell, Armin; Wurth, Roman; Ruessel, Christian; Boesecke, Peter; Vainio, Ulla [Institute of Applied Materials, Helmholtz-Zentrum Berlin fuer Materialien und Energie, Albert-Einstein-Strasse 15, D-12489 Berlin (Germany); Otto-Schott-Institut fuer Glaschemie, Friedrich-Schiller-Universitaet Jena, Fraunhoferstrasse 6, D-07743 Jena (Germany); European Synchrotron Radiation Facility (ESRF), 6 Rue Jules Horowitz, BP 220, 38043 Grenoble Cedex 9 (France); HASYLAB at DESY, Notkestrasse 85, D-22607 Hamburg (Germany)

    2010-05-01T23:59:59.000Z

    Here, we describe the analysis of the nanostructure and average chemical compositions of each phase present in an oxyfluoride glass ceramic, which is composed of fluoride nanocrystals and an oxide glass matrix. The overall composition of the oxyfluoride glass ceramic as prepared is 21.1%SiO{sub 2} 6.5%B{sub 2}O{sub 3} 7.0%Al{sub 2}O{sub 3} 21.0%PbF{sub 2} 14.3%CdF{sub 2} 11.0%YbF{sub 3} 0.5%ErF{sub 3} 11.0%PbO 7.6%CdO(mole %). Nanocrystals begin to grow at temperatures above the glass transformation temperature at 678 K as observed by x-ray diffraction. We report results from anomalous small-angle x-ray scattering taken at energies of x-ray absorption edges of Er, Yb, Pb, and Cd. By nonlinear regression of the scattering curves obtained from different edges simultaneously, the nanocrystals were found to be describable as polydisperse spheroids. The length of the smaller axis was found to be 6.4+-1.4 nm while the larger axis was found to be 17.7+-3.9 nm. By analyzing the scattering contrast as a function of the x-ray energy we found cadmium only in the glass matrix.

  18. Final Technical Report for DOE DE-FG02-05ER54831 "Laboratory Studies of Dynamos."

    SciTech Connect (OSTI)

    Forest, Cary B. [UW-Madison

    2014-11-06T23:59:59.000Z

    Laboratory Studies of Dynamos: Executive Summary. The self-generation of magnetic #12;fields by astrophysical bodies like planets, stars, accretion disks, galaxies, and even galaxy clusters arises due to a mechanism referred to as a homogeneous dynamo. It is quite simple to demonstrate the generation of a magnetic fi#12;eld from a rotating copper disk coupled with a coil of wire, a device known as the homopolar dynamo. The device works like a magnetic fi#12;eld ampli#12;er with a feedback circuit: the differential rotation of a metal disk past an infinitesimally small seed magnetic field induces currents in the disk which, when coupled to a coil winding, can amplify the #12;field until it becomes strong enough to slow the rotation of the disk. What is remarkable is that the same type of circuit may be achieved in a flowing conducting fluid such as a liquid metal in the case of planetary dynamos or a plasma in the case of astrophysical dynamos. The complexity of describing planetary and stellar dynamos despite their ubiquity and the plethora of observational data from the Earth and the Sun motivates the demonstration of a laboratory homogenous dynamo. To create a homogenous dynamo, one #12;first needs a su#14;fficiently large, fast flow of a highly conducting fluid that the velocity shear in the fluid can bend magnetic #12;field lines. With a high Rm-flow, the magnetic fi#12;eld can be ampli#12;ed by the stretching action provided by di#11;fferential rotation. The other critical ingredient is a flow geometry that provides feedback so that the ampli#12;ed #12;eld reinforces the initial in#12;nitesimal seed #12;field - a mechanism that recreates the feedback provided by the coil of wire in the homopolar dynamo. In the Madison Dynamo Experiment, this combination of magnetic ampli#12;cation and feedback is feasible in the simple geometry of two counter-rotating helical vortices in a 1 meter-diameter spherical vessel #12;lled with liquid sodium. For an optimal helical pitch of the flow the threshold for exciting a dynamo is predicted from laminar flow modeling to be at peak flow speeds of 5 m/s. Liquid metals tend to have viscosities similar to that of water yielding inviscid flows. Whereas the timescale for the dynamo instability is on the resistive dissipation time, the timescale for hydrodynamic instability of the shear layer is quite short meaning that the shear layer required to generate the magnetic #12;eld is broken up by Kelvin-Helmholtz instabilities. The eddies generated by large-scale flow drive instabilities at progressively smaller scale giving rise to a cascade of turbulent eddies driven at the largest scale of the experiment. The major contribution of the Madison Dynamo Experiment has been quantifying the role this turbulence plays in the generation of magnetic #12;elds. Overall, the Madison Dynamo Experiment has now operated for about 1 decade and carried out experiments related to magnetic fi#12;eld generation by turbulent flows of liquid metal. The principle thrust of research and indeed the main scienti#12;fic outcomes are related to how turbulent flows create and transport magnetic fi#12;elds.

  19. The laboratory rat strains most commonly used in research are believed to be domesticated albino strains of the Norway rat rattus nirvegicus. Rats like mice, belong to the order Rodentia

    E-Print Network [OSTI]

    Shihadeh, Alan

    and the nude rat. Uses Despite the fear that rats invoke in people they actually make quiet, gentle pets rate 70-115 Food consumption 5-6g/100g/d Water consumption 10-12ml/100g/d Breeding onset Male 65-110d

  20. Original article Digestion and fermentation of proteins in rats fed

    E-Print Network [OSTI]

    Boyer, Edmond

    Original article Digestion and fermentation of proteins in rats fed keratin, albumin, cooked casein the hypothesis that cooking reduces the digestibility of casein, and increases the yield of bacterial me transfer and fermentation in the caecum. The caecal digestion of casein (cooked or not), ker- atin

  1. Facial Wiping in the Rat Fetus: Variation of Chemosensory

    E-Print Network [OSTI]

    Robinson, Scott R.

    how variation in stimulus parameters of lemon odor infusion (concentration, volume, and infusion time) affected the wiping response of E20 rat fetuses. Infusions of higher concentration or greater volume of stimulation. Intraoral infusion of chemosensory fluids with strong olfactory components, such as lemon extract

  2. Aardvark hunt in Kenya Gaten B. Rat}rUin

    E-Print Network [OSTI]

    I I i Aardvark hunt in Kenya Gaten B. Rat}rUin Dept of Omittrologr & Mamrnalogr, Catifomia Academy eactrirg science as a Peace Corps Volunteer at Mirogi $conOary Scnou in Sou*r Nyanza District or Kenya of Kenya in Nairobi. 14 #12;

  3. Effects of Methanol on the Retinal Function of Juvenile Rats

    E-Print Network [OSTI]

    Casanova, Christian

    Effects of Methanol on the Retinal Function of Juvenile Rats C. Plaziac1 , P. Lachapelle2 , C Received 18 April 2002; accepted 22 July 2002 Abstract We have investigated the effect of methanol exposure recorded prior to and up to 72 h after the administration of methanol. Data were compared to a control

  4. PROTECTIVE EFFECTS OF VERAPAMIL AGAINST HEXACHLOROBUTADIENE NEPHROTOXICITY IN RATS

    E-Print Network [OSTI]

    E. Moghtadai Khorasgani; K. Manochehri; M. Hosseini

    In order to evaluate the protective effect of verapamil against hexachlorobutadiene (HCBD) nephrotoxicity, 30 adult Wistar albino rats were divided into five equal groups, A, B, C, D and E and were given intra-peritonially corn oil (I ml/kg; control), HCBD (50 mg/kg), verapamil (50 µg/kg) with HCBD

  5. Inconclusive Experiment with Rats By Bill Menke, December 1, 2013

    E-Print Network [OSTI]

    Menke, William

    of genetically-modified corn. The Times article says: The editor of the journal, Food and Chemical Toxicology the paper's main result, that rats fed genetically-modified, herbicide-resistant corn have a higher incident was a bit disingenuous of him. I do find delicious the irony that Séralini's paper is critiquing genetically-modified

  6. Single Glucose Biofuel Cells Implanted in Rats Power Electronic Devices

    E-Print Network [OSTI]

    Boyer, Edmond

    Single Glucose Biofuel Cells Implanted in Rats Power Electronic Devices A. Zebda1,2 , S. Cosnier1 the first implanted glucose biofuel cell (GBFC) that is capable of generating sufficient power from a mammal further developments. Following recent developments in nano- and biotechnology, state-of-the-art biofuel

  7. Nitrogen sparing by 2-ketoisocaproate in parenterally fed rats

    SciTech Connect (OSTI)

    Yagi, M.; Matthews, D.E.; Walser, M. (Johns Hopkins Univ. School of Medicine, Baltimore, MD (USA))

    1990-11-01T23:59:59.000Z

    In rats receiving total parenteral nutrition with or without sodium 2-ketoisocaproate (KIC; 2.48 g.kg-1.day-1), L-(1-{sup 13}C)leucine and (1-{sup 14}C)KIC were constantly infused for 6 h. CO{sub 2} production, {sup 14}CO{sub 2} production, {sup 13}CO{sub 2} enrichment, urinary urea nitrogen (N) plus ammonia N and total urinary N were measured. Whole body protein synthesis (S) was calculated in non-KIC-infused rats and also in unfed rats infused with (1-{sup 14}C)leucine from fractional oxidation of labeled leucine (1-F), where F is fractional utilization for protein synthesis, and urea N plus ammonia N excretion (C) as S = C x F/(1-F). Addition of KIC caused a significant reduction in N excretion and a significant improvement in N balance. Fractional oxidation of labeled KIC increased, whereas fractional utilization of labeled KIC for protein synthesis decreased, but the extent of incorporation of infused KIC into newly synthesized protein (as leucine) amounted to at least 40% of the total rate of leucine incorporation into newly synthesized whole body protein. We conclude that addition of KIC spares N in parenterally fed rats and becomes a major source of leucine for protein synthesis.

  8. adult rat brain: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    rat brain First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Thyroid hormone regulates hippocampal...

  9. JET PROPULSION LAB 0 RAT 0 R Y

    E-Print Network [OSTI]

    Waliser, Duane E.

    JET PROPULSION LAB 0 RAT 0 R Y ANN U A L REP 0 R T #12;#12;------ - - ~ CON TEN T S DIRECTOR Administration for the penod January 1 through December 31, 1986. JET PROPULSION LABORATORY Califorrua Institute, Voyager 2 gave us our first close view of the distant giant Uranus, its complex rings, inclined magnetic

  10. Susceptibility of immature rats to seizures induced by unsymmetrical dimethylhydrazine

    E-Print Network [OSTI]

    Boyd, Dale Duaine

    1963-01-01T23:59:59.000Z

    . Bain. Convulsant hydrazides I. In vito and in vivo inhibition of vitamin B6 enzymes by convulsive hydrazides. J. Pharmacol. Exp. Ther. 119:255-262 (1957). 8. Baxter, C. F. , and E. Roberts. Elevation of gamma-aminobutyric acid in rat brain...

  11. Ultrastructure of Primary Afferent Terminals and Synapses in the Rat

    E-Print Network [OSTI]

    Hill, David L.

    Ultrastructure of Primary Afferent Terminals and Synapses in the Rat Nucleus of the Solitary Tract tympani (CT), and glossopharyngeal (IX) nerves terminate in overlapping patterns in the brainstem electron microscopy. Although all three nerves had features charac- teristic of excitatory nerve terminals

  12. Effect of Mn doping on structural and magnetic susceptibility of C-type rare earth nano oxides Er{sub 2?x}Mn{sub x}O{sub 3}

    SciTech Connect (OSTI)

    Heiba, Zein K. [Ain Shams University, Faculty of Science, Physics Department, Cairo (Egypt) [Ain Shams University, Faculty of Science, Physics Department, Cairo (Egypt); Taif University, Faculty of Science, Physics Department (Saudi Arabia); Mohamed, Mohamed Bakr, E-mail: mbm1977@yahoo.com [Ain Shams University, Faculty of Science, Physics Department, Cairo (Egypt); Fuess, H. [Materials Science, Darmstadt University of Technology, D-64289 Darmstadt (Germany)] [Materials Science, Darmstadt University of Technology, D-64289 Darmstadt (Germany)

    2012-12-15T23:59:59.000Z

    Graphical abstract: Display Omitted Highlights: ? Er{sub 2?x}Mn{sub x}·O{sub 3} (0.0 ? x ? 0.20) prepared by sol–gel method. ? The change in lattice parameter is not linear with x due to the change in crystallite size with doping. ? Anomalous concentration dependence is found in magnetic susceptibility. ? The effective magnetic moment ?{sub eff} is found to decrease with composition parameter x. ? Superexchange interactions between Er ions depending on the amount of Mn or Er in different sites. -- Abstract: The manganese doped rare earth oxides Er{sub 2?x}Mn{sub x} O{sub 3} (0.0 ? x ? 0.20) were synthesized by a sol–gel process and analyzed by X-ray diffraction using Rietveld refinement methods. A single phase solid solution is formed up to x = 0.15 while for x ? 0.2 a manganese oxide phase appears in the diffraction pattern. Preferential cationic distribution between the non-equivalent sites 8b and 24d of space group Ia3{sup ¯} is found for all samples but to a different extent. The octahedral volume and average bond length of Er{sub 1}-O for 8b site decrease while both octahedral volume and bond length of Er{sub 2}-O for 24d site increase. Magnetization measurements were done in the temperature range 5–300 K. The effective magnetic moment ?{sub eff} is found to decrease with composition parameter x, except for sample x = 0.05 where the magnetization is enhanced. The Curie-Weiss paramagnetic temperatures indicate antiferromagnetic interaction.

  13. Characterization and Mapping of the Gene Conferring Resistance to Rift Valley Fever Virus Hepatic Disease in WF.LEW Rats

    E-Print Network [OSTI]

    Callicott, Ralph J.

    2010-01-14T23:59:59.000Z

    168 271 164 218 243 142 154 268 168 271 164 218 243 142 D6Rat46 D6Rat68 D6Rat105 D6Rat74 D6Rat144 D6Rat135 D6Rat124 D6Rat116 D6Rat1 155 278 246 253 185 169 260 152 238 155 278 244 255 181 169 260... 220 242 181 349 134 177 256 132 131 160 165 216 242 181 349 134 177 256 132 133 148 159 220 248 203 349 126 175 246 138 171 160 163 214 248 203 349 126 175 246 138 171 160 163 214 248 203 349...

  14. Laser-induced magnetic fields in ICF capsules, Final Report, DE-FG02-08ER85128, Phase 1

    SciTech Connect (OSTI)

    Lindman, Erick L

    2009-11-05T23:59:59.000Z

    Laser-induced magnetic fields in ICF capsules Final Report, DE-FG02-08ER85128, Phase 1 E. L. LINDMAN, Otowi Technical Services, Los Alamos, NM. The performance of an inertial-confinement-fusion (ICF) capsule can be improved by inserting a magnetic field into it before compressing it [Kirkpatrick, et al., Fusion Technol. 27, 205 (1995)]. To obtain standoff in an ICF power generator, a method of inserting the field without the use of low-inductance leads attached to the capsule is desired. A mechanism for generating such a field using a laser was discovered in Japan [Sakagami, et al., Phys. Rev. Lett. 42, 839 (1979), Kolodner and Yablonovitch, Phys. Rev. Lett. 43, 1402 (1979)] and studied at Los Alamos in the 1980s [M. A. Yates, et al., Phys. Rev. Lett. 49, 1702 (1982); Forslund and Brackbill, Phys. Rev. Lett. 48, 1614 (1982)]. In this mechanism, a p-polarized laser beam strikes a solid target producing hot electrons that are accelerated away from the target surface by resonant absorption. An electric field is created that returns the hot electrons to the target. But, they do not return to the target along the same trajectory on which they left. The resulting current produces a toroidal magnetic field that was observed to spread over a region outside the hot spot with a radius of a millimeter. No experimental measurements of the magnetic field strength were performed. Estimates from computer simulation suggest that field strengths in the range of 1 to 10 Mega gauss (100 to 1000 Tesla) were obtained outside of the laser spot. To use this mechanism to insert a magnetic field into an ICF capsule, the capsule must be redesigned. In one approach, a central conductor is added, a toroidal gap is cut in the outer wall and the DT fuel is frozen on the inner surface of the capsule. The capsule is dropped into the reaction chamber and struck first with the laser that generates the magnetic field. The laser hot spot is positioned at the center of the toroidal gap. As the magnetic field spreads from the hot spot over the surface that contains the toroidal gap, it will propagate through the gap and set up a steady state in the capsule. The main compression is then initiated. First, it closes the gap and crow-bars the field, then it compresses the fuel to ignition. In addition to this application, we discuss the use of this mechanism to induce Mega-gauss fields in laboratory apparatus for measurements of the effects of large magnetic fields on material samples. A preliminary target design for this purpose is presented. It is made of high-density material with no hydrogen surface contamination to minimize fast ion losses and to minimize x-ray preheat of the sample (the material, whose magnetic properties are to be measured). In it, the gap is designed to allow the magnetic field to move into the interior of the target while minimizing the flow of hot electrons into the interior. By adjusting the size of the gap as well as its configuration, the hot electron effects can be minimized. Since the strength of the magnetic field depends on the radial distance to the sample from the center of the conductor carrying the return current, the sample is located at a point of minimum conductor radius. This location also minimizes the effects on the measurement of any hot electrons that flow into the interior. Useful experiments can be accomplished with the “seed” field alone in this geometry. Compressing the capsule after the insertion of the seed field may allow experiments with even larger magnetic fields. We have used computer-simulation techniques to address a number of issues. Our conclusions include: • This magnetic-field generating mechanism is a viable method for generating magnetic fields in ICF targets and for laboratory experiments. • Useful experiments on material samples can be done with the seed field of 1 to10 Mega gauss (100 to 1000 Tesla) and higher magnetic fields can be obtained by subsequently compressing the capsule. • The results reported here can be studied experimentally with a modest CO2 laser that emits 4.5 J of ene

  15. Hemodynamic characterization of chronic bile duct-ligated rats: effect of pentobarbital sodium

    SciTech Connect (OSTI)

    Lee, S.S.; Girod, C.; Braillon, A.; Hadengue, A.; Lebrec, D.

    1986-08-01T23:59:59.000Z

    Systemic and splanchnic hemodynamics of the chronic bile duct-ligated rat were characterized by radioactive microspheres. Conscious and pentobarbital sodium-anesthetized, bile duct-ligated and sham-operated rats had cardiac output and regional organ blood flows determined. The conscious bile duct-ligated rat compared with the sham-operated showed a hyperdynamic circulation with an increased cardiac output and portal tributary blood flow. Pentobarbital sodium anesthesia induced marked hemodynamic changes in both sham-operated and bile duct-ligated rats. The latter group was especially sensitive to its effects; thus, comparison of cardiac output and portal tributary blood flow between anesthetized bile duct-ligated and sham-operated rats showed no significant differences. The authors conclude that the rat with cirrhosis due to chronic bile duct ligation is an excellent model for hemodynamic investigations but should be studied in the conscious state, since pentobarbital sodium anesthesia eliminated the hyperdynamic circulation.

  16. Analysis of In situ Observations of Cloud Microphysics from M-PACE Final Report, DOE Grant Agreement No. DE-FG02-06ER64168

    SciTech Connect (OSTI)

    Michael R. Poellot

    2009-01-09T23:59:59.000Z

    This report summarizes the findings and accomplishments of work performed under DOE Grant Agreement No. DE-FG02-06ER64168. The focus of the work was the analysis of in situ observations collected by the University of North Dakota Citation research aircraft during the Mixed-Phase Arctic Cloud Experiment (M-PACE). This project was conducted in 2004 along the North Slope of Alaska. The objectives of the research were: to characterize certain microphysical properties of clouds sampled during M-PACE, including spatial variability, precipitation formation, ice multiplication; to examine instrument performance and certain data processing algorithms; and to collaborate with other M-PACE investigators on case study analyses. A summary of the findings of the first two objectives is given here in parts 1 and 2; full results are contained in reports listed in part 3 of this report. The collaborative efforts are described in the publications listed in part 3.

  17. Wideband saturable absorption in few-layer molybdenum diselenide (MoSe2) for Q-switching Yb-, Er- and Tm-doped fiber lasers

    E-Print Network [OSTI]

    Woodward, R I; Runcorn, T H; Hu, G; Torrisi, F; Kelleher, E J R; Hasan, T

    2015-01-01T23:59:59.000Z

    We fabricate a free-standing molybdenum diselenide (MoSe2) saturable absorber by embedding liquid-phase exfoliated few-layer MoSe2 flakes into a polymer film. The MoSe2-polymer composite is used to Q-switch fiber lasers based on ytterbium (Yb), erbium (Er) and thulium (Tm) gain fiber, producing trains of microsecond-duration pulses with kilohertz repetition rates at 1060 nm, 1566 nm and 1924 nm, respectively. Such operating wavelengths correspond to sub-bandgap saturable absorption in MoSe2, which is explained in the context of edge-states, building upon studies of other semiconducting transition metal dichalcogenide (TMD)-based saturable absorbers. Our work adds few-layer MoSe2 to the growing catalog of TMDs with remarkable optical properties, which offer new opportunities for photonic devices.

  18. A new reasonable scenario to search for ER-alpha energy-time-position correlated sequences in a real time mode

    E-Print Network [OSTI]

    Tsyganov, Y S

    2015-01-01T23:59:59.000Z

    A new real-time PC based algorithm and a compact C++ code to operate in a real-time mode with a 48x128 strip double side position sensitive large area silicon radiation detector Micron Semiconductors (UK) are developed and tested. Namely with this new approach it has become possible to provide the quick extraction of EVR-alpha correlated sequences in heavy ion induced complete fusion nuclear reactions. Specific attention is paid to the application of new CAMAC 4 M modules for charge particle position measurement during long- term experiments aimed to the synthesis of new superheavy nuclei. Some attention is paid to the different (combined) algorithm scenario to search for ER-alpha and alpha-alpha chains.

  19. Enhanced 2.7 ?m emission from Er{sup 3+} doped oxyfluoride tellurite glasses for a diode-pump mid-infrared laser

    SciTech Connect (OSTI)

    Zhang, F. F.; Yuan, J.; Chen, D. D.; Qian, Q.; Zhang, Q. Y., E-mail: qyzhang@scut.edu.cn [State Key Laboratory of Luminescence Materials and Devices, and Institute of Optical Communication Materials, South China University of Technology, Guangzhou 510641 (China); Zhang, W. J. [Shandong Provincial Key Laboratory of Preparation and Measurement of Building Materials, University of Jinan, Jinan 250022 (China)] [Shandong Provincial Key Laboratory of Preparation and Measurement of Building Materials, University of Jinan, Jinan 250022 (China)

    2014-04-15T23:59:59.000Z

    The influence of fluoride and shielding gas (O{sub 2} or Ar) on the physical and spectroscopic properties of Er{sup 3+} doped TeO{sub 2}-ZnO-ZnF{sub 2} glass system is investigated. The larger electronegativity of F than O accounts for the gradual decrease of refractive index, density, and J-O parameters with increasing ZnF{sub 2}. An analysis on Fourier transform infrared transmission spectra reveals that the absorption coefficient of OH{sup ?} around 3 ?m as low as 0.247 cm{sup ?1} can be achieved when 30 mol% ZnF{sub 2} containing sample is treated with Ar gas during glass melting process. The reduction of OH{sup ?} groups combined with the low multiphonon relaxation rate (207 s{sup ?1}) contributes to the enhanced emissions at 1.5 and 2.7 ?m, along with prolonged lifetimes of {sup 4}I{sub 11/2} and {sup 4}I{sub 13/2} levels. A high branching ratio (17.95%) corresponding to the Er{sup 3+}: {sup 4}I{sub 11/2} ? {sup 4}I{sub 13/2} transition, the large absorption and emission cross section (0.44 × 10{sup ?20} cm{sup 2} and 0.45 × 10{sup ?20} cm{sup 2}), and good gain cross section demonstrate that oxyfluoride tellurite glass could be a promising material for a diode-pump 2.7 ?m fiber laser.

  20. Synthesis and characterization of ultrafine Ln{sub 2}Ti{sub 2}O{sub 7} (Ln = Sm, Gd, Dy, Er) pyrochlore oxides by stearic acid method

    SciTech Connect (OSTI)

    Zhang Weiguang, E-mail: zhangweiguang68@yahoo.com.cn [Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, Huaiyin Normal University, Jiangsu Province, 223300 (China); Zhang Lili; Zhong Hui [Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, Huaiyin Normal University, Jiangsu Province, 223300 (China); Lu Lude; Yang Xujie [Materials Chemistry Laboratory, Nanjing University of Science and Technology, Nanjing 210094 (China); Wang Xin, E-mail: wangx@mail.njust.edu.cn [Materials Chemistry Laboratory, Nanjing University of Science and Technology, Nanjing 210094 (China)

    2010-02-15T23:59:59.000Z

    Stearic acid method (SAM) was developed to synthesize series of pyrochlore Ln{sub 2}Ti{sub 2}O{sub 7} (Ln = Sm, Gd, Dy, Er) nanocrystals. The synthesis process was monitored by X-ray diffraction, Thermal-gravimetric-differential thermal analysis and Fourier Transform InfraRed methods. Comparing with traditional solid-state reaction (SSR), Ln{sub 2}Ti{sub 2}O{sub 7} can be synthesized at relatively low temperature (700-800 deg. C) with shortened reaction time (2-4 h). The average particle size of Ln{sub 2}Ti{sub 2}O{sub 7} was greatly reduced (ca. 40 nm) and the BET surface area was increased (ca. 12 m{sup 2}/g) by using SAM. From the X-ray diffraction patterns, we found that Ln has an effect on the crystal structure of Ln{sub 2}Ti{sub 2}O{sub 7}, every lattice peak shifted to larger angle slightly with the increasing atomic number of Ln. Also, the lattice constant of Ln{sub 2}Ti{sub 2}O{sub 7} was calculated by Jade.5 and found it decreased along with the decrease of ionic radius of Ln{sup 3+}. The morphology of obtained Ln{sub 2}Ti{sub 2}O{sub 7} was determined by transmission electron microscopy technique. Results showed that the obtained Ln{sub 2}Ti{sub 2}O{sub 7} were all square-like and the interplanar distance of Ln{sub 2}Ti{sub 2}O{sub 7} (Ln = Sm, Gd, Dy, Er) according to (111) plane was 0.65, 0.64, 0.63, and 0.62 nm respectively, which was measured from High Resolution Transmission Electron Microscopy images. Possible reason for this phenomenon was presented.

  1. Experimental cross sections of 165Ho(?,n)168Tm and 166Er(?,n)169Yb for optical potential studies relevant for the astrophysical ?-process

    E-Print Network [OSTI]

    Jan Glorius; Kerstin Sonnabend; Joachim Goerres; Daniel Robertson; Michael Knoerzer; Antonios Kontos; Thomas Rauscher; René Reifarth; Anne Sauerwein; Edward Stech; Wanpeng Tan; Tanija Thomas; Michael Wiescher

    2014-07-07T23:59:59.000Z

    Background: Optical potentials are crucial ingredients for the prediction of nuclear reaction rates needed in simulations of the astrophysical \\gamma-process. Associated uncertainties are particularly large for reactions involving \\alpha-particles. This includes (\\gamma,\\alpha) reactions which are of special importance in the \\gamma-process. Purpose: The measurement of (\\alpha,n) reactions allows for an optimization of currently used \\alpha-nucleus potentials. The reactions 165Ho(\\alpha,n) and 166Er(\\alpha,n) probe the optical model in a mass region where \\gamma-process calculations exhibit an underproduction of p nuclei which is not yet understood. Method: To investigate the energy-dependent cross sections of the reactions 165Ho(\\alpha,n) and 166Er(\\alpha,n) close to the reaction threshold, self-supporting metallic foils were irradiated with \\alpha-particles using the FN tandem Van de Graaff accelerator at University of Notre Dame. The induced activity was determined afterwards by monitoring the specific \\beta-decay channels. Results: Hauser-Feshbach predictions with a widely used global \\alpha-potential describe the data well at energies where the cross sections are almost exclusively sensitive to the \\alpha-widths. Increasing discrepancies appear towards the reaction threshold at lower energy. Conclusions: The tested global \\alpha-potential is suitable at energies above 14 MeV, while a modification seems necessary close to the reaction threshold. Since the \\gamma- and neutron width show non-negligible impact on the predictions, complementary data are required to judge whether or not the discrepancies found can to be solely assigned to the \\alpha-width.

  2. Regulation of Endothelial Phenotype in Rat Soleus Muscle Feed Arteries: Influence of Aging and Exercise Training

    E-Print Network [OSTI]

    Trott, Daniel Wayne

    2012-02-14T23:59:59.000Z

    arrival, rats were exercise trained (Ex) or remained sedentary (Sed) for 10-12 weeks. Thus, at the end of the training program, the ages of the young and old rats were 4-5 mo or 24-25 mo respectively. The resulting experimental design consisted... of four groups of rats: 1) young Sed (n = 10), 2) young Ex (n = 10), 3) old Sed (n = 10), and 4) old Ex (n = 10). To determine whether exogenous antioxidants produce exercise-like effects on aged SFA, a separate group of male Fischer 344 rats (4...

  3. Brain reward deficits accompany withdrawal (hangover) from acute ethanol in rats

    E-Print Network [OSTI]

    Schulteis, Gery; Liu, Jian

    2006-01-01T23:59:59.000Z

    stimulation reward: effects of ethanol. Alcohol Clin Exp Resstimulus produced by ethanol withdrawal. J Pharmacol Expthe "anxiogenic" response to ethanol withdrawal in the rat.

  4. 3D MRI of Non-Gaussian He Gas Diffusion in the Rat Lung. | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Results show that the non-Gaussian effects of ³He gas diffusion in healthy rat lungs are directly attributed to the anisotropic geometry of lung microstructure, and that...

  5. Effects of combined hyperoxia and cyclooxygenase inhibition in neonatal rat lungs

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    K. Effect of indomethacin on lung development in postnatalinhibition & neonatal rat lungs the fetal ductus arteriosus.expression in human lungs of newborns with congenital

  6. SYN T H E S I STHE magazinE OF UC DAVIS CANCER CENTER VOL 14 nO 1 SPRing/SUmmER 2011 making their mark against

    E-Print Network [OSTI]

    Leistikow, Bruce N.

    and treatments. Establishment of an epidemiological "shared resource" will help the cancer center formalize ourSYN T H E S I STHE magazinE OF UC DAVIS CANCER CENTER VOL 14 · nO 1 · SPRing/SUmmER 2011 making their mark against breast cancer pA g E 2 2 Radiologist brings modern mammography, screening expertise

  7. 1228 CROP SCIENCE, VOL. 39, JULYAUGUST 1999 Marshall, D.R., and R.W. Allard. 1970. Isozyme polymorphism in ers and isozymes in lentil. Ph.D. Diss. Univ. of Saskatchewan,

    E-Print Network [OSTI]

    Gepts, Paul

    polymorphism in ers and isozymes in lentil. Ph.D. Diss. Univ. of Saskatchewan, natural populations of Avena.) Verdc.] is an impor- naeus (1763) described it from a plant from Surinam.tant crop in many countries population structure and (Brouk, 1975). the partitioning of genetic diversity between domesticated and wild

  8. Apport de l'imagerie radar SAR-ERS l'analyse de la gomtrie de la dformation rcente dans les monts Bni Snassen (Maroc) PANGEA No. 45/46 Hassan Tabyaoui et al. June / December 2009

    E-Print Network [OSTI]

    Boyer, Edmond

    monts Béni Snassen (Maroc) PANGEA No. 45/46 Hassan Tabyaoui et al. June / December 2009 18 Apport de l (Maroc nord-oriental) Contribution of the imagery radar SAR-ERS to the analysis of the geometry Modélisation, Equipe Risques Naturels, Aménagement des Territoires et Environnement, BP 1223, Taza-Gare, Maroc

  9. Thermoelectric power generator module of 1616 Bi2Te3 and 0.6% ErAs:,,InGaAs...1-x,,InAlAs...x segmented elements

    E-Print Network [OSTI]

    Bowers, John

    Thermoelectric power generator module of 16Ã16 Bi2Te3 and 0.6% ErAs:,,InGaAs...1-x; published online 26 August 2009 We report the fabrication and characterization of thermoelectric power temperature was at 610 K. The thermoelectric properties of InGaAs 1-x InAlAs x were characterized from 300 up

  10. Magnetic properties and magnetocaloric effect in the RCu{sub 2}Si{sub 2} and RCu{sub 2}Ge{sub 2} (R?=?Ho, Er) compounds

    SciTech Connect (OSTI)

    Mo, Zhao-Jun [School of Material Science and Engineering, Hebei University of Technology, Tianjin (China); Key laboratory of cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing (China); Shen, Jun, E-mail: jshen@mail.ipc.ac.cn, E-mail: tangcc@hebut.edu.cn; Wu, Jian-Feng [Key laboratory of cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing (China); Yan, Li-Qin; Wang, Li-Chen; Sun, Ji-rong; Shen, Bao-Gen [State Key Laboratory of Magnetism, Beijing National Laboratory for Condensed Matter, Physics and Institute of Physics, Chinese Academy of Sciences, Beijing (China); Gao, Xin-Qiang; Tang, Cheng-Chun, E-mail: jshen@mail.ipc.ac.cn, E-mail: tangcc@hebut.edu.cn [School of Material Science and Engineering, Hebei University of Technology, Tianjin (China)

    2014-02-21T23:59:59.000Z

    The magnetic properties and magnetocaloric effect (MCE) in RCu{sub 2}Si{sub 2} and RCu{sub 2}Ge{sub 2} (R?=?Ho, Er) compounds have been investigated. All these compounds possess an antiferromagnetic (AFM)-paramagnetic (PM) transition around their respective Neel temperatures. The RCu{sub 2}Si{sub 2} compounds undergo spin-glassy behavior above Neel temperature. Furthermore, a field-induced metamagnetic transition from AFM to ferromagnetic (FM) states is observed in these compounds. The calculated magnetic entropy changes show that all RCu{sub 2}Si{sub 2} and RCu{sub 2}Ge{sub 2} (R?=?Ho, Er) compounds, especially, ErCu{sub 2}Si{sub 2} exhibits large MCEs with no thermal hysteresis and magnetic hysteresis loss. The value of ??S{sub M}{sup max} reaches 22.8?J/Kg K for magnetic field changes from 0 to 5?T. In particular, for field changes of 1 and 2?T, the giant reversible magnetic entropy changes ??S{sub M}{sup max} are 8.3 and 15.8?J/kg K at 2.5?K, which is lower than the boiling point of helium. The low-field giant magnetic entropy change, together with ignorable thermal hysteresis and field hysteresis loss of ErCu{sub 2}Si{sub 2} compound is expected to have effective applications in low temperature magnetic refrigeration.

  11. IEEE TransacTIons on UlTrasonIcs, FErroElEcTrIcs, and FrEqUEncy conTrol, vol. 59, no. 11, novEmbEr 2012 2373 08853010/$25.00 2012 IEEE

    E-Print Network [OSTI]

    Pilon, Laurent

    - moelectrical loading. I. Introduction large amounts of waste heat are released from pow- er generation, heating. It was estimated that 58% of the energy consumed in the United states in 2009 was lost as waste heat, which was typically discharged to the environment [1]. more than 80% of this waste heat was produced by electricity

  12. Integrated transcriptomic and proteomic evaluation of gentamicin nephrotoxicity in rats

    SciTech Connect (OSTI)

    Com, Emmanuelle, E-mail: emmanuelle.com@univ-rennes1.fr [sanofi-aventis R and D, Disposition Safety and Animal Research, Vitry-sur-Seine (France) [sanofi-aventis R and D, Disposition Safety and Animal Research, Vitry-sur-Seine (France); INSERM U625, Proteomics Core Facility Biogenouest, Rennes (France); Boitier, Eric; Marchandeau, Jean-Pierre [sanofi-aventis R and D, Disposition Safety and Animal Research, Vitry-sur-Seine (France)] [sanofi-aventis R and D, Disposition Safety and Animal Research, Vitry-sur-Seine (France); Brandenburg, Arnd [Genedata AG, Basel (Switzerland)] [Genedata AG, Basel (Switzerland); Schroeder, Susanne [Nycomed GmbH, Barsbüttel (Germany)] [Nycomed GmbH, Barsbüttel (Germany); Hoffmann, Dana; Mally, Angela [University of Würzburg, Department of Toxicology, University of Würzburg, Würzburg (Germany)] [University of Würzburg, Department of Toxicology, University of Würzburg, Würzburg (Germany); Gautier, Jean-Charles [sanofi-aventis R and D, Disposition Safety and Animal Research, Vitry-sur-Seine (France)] [sanofi-aventis R and D, Disposition Safety and Animal Research, Vitry-sur-Seine (France)

    2012-01-01T23:59:59.000Z

    Gentamicin is an aminoglycoside antibiotic, which induces renal tubular necrosis in rats. In the context of the European InnoMed PredTox project, transcriptomic and proteomic studies were performed to provide new insights into the molecular mechanisms of gentamicin-induced nephrotoxicity. Male Wistar rats were treated with 25 and 75 mg/kg/day subcutaneously for 1, 3 and 14 days. Histopathology observations showed mild tubular degeneration/necrosis and regeneration and moderate mononuclear cell infiltrate after long-term treatment. Transcriptomic data indicated a strong treatment-related gene expression modulation in kidney and blood cells at the high dose after 14 days of treatment, with the regulation of 463 and 3241 genes, respectively. Of note, the induction of NF-kappa B pathway via the p38 MAPK cascade in the kidney, together with the activation of T-cell receptor signaling in blood cells were suggestive of inflammatory processes in relation with the recruitment of mononuclear cells in the kidney. Proteomic results showed a regulation of 163 proteins in kidney at the high dose after 14 days of treatment. These protein modulations were suggestive of a mitochondrial dysfunction with impairment of cellular energy production, induction of oxidative stress, an effect on protein biosynthesis and on cellular assembly and organization. Proteomic results also provided clues for potential nephrotoxicity biomarkers such as AGAT and PRBP4 which were strongly modulated in the kidney. Transcriptomic and proteomic data turned out to be complementary and their integration gave a more comprehensive insight into the putative mode of nephrotoxicity of gentamicin which was in accordance with histopathological findings. -- Highlights: ? Gentamicin induces renal tubular necrosis in rats. ? The mechanisms of gentamicin nephrotoxicity remain still elusive. ? Transcriptomic and proteomic analyses were performed to study this toxicity in rats. ? Transcriptomic and proteomic data turned out to be complementary and are integrated. ? A more comprehensive putative model of nephrotoxicity of gentamicin is presented.

  13. Albumin extravasation rates in tissues of anesthetized and unanesthetized rats

    SciTech Connect (OSTI)

    Renkin, E.M.; Joyner, W.L.; Gustafson-Sgro, M.; Plopper, G.; Sibley, L.

    1989-05-01T23:59:59.000Z

    Bovine serum albumin (BSA) labeled with /sup 131/I was injected intravenously in chronically prepared, unanesthetized rats and into pentobarbital-anesthetized rats that had received 2 ml 5% BSA to help sustain plasma volume. Initial uptake rates (clearances) in skin, skeletal muscles, diaphragm, and heart (left ventricle) were measured over 1 h. BSA labeled with /sup 125/I was injected terminally to correct for intravascular /sup 131/I-BSA. Observed clearances were in the following order in both groups of animals: heart much greater than diaphragm approximately equal to skin greater than resting skeletal muscles. Differences between unanesthetized and anesthetized animals were small and inconsistently directed. Our results suggest that the lower albumin clearances reported in the literature for anesthetized rats are not the result of their immobility or any direct effect of anesthesia on albumin transport in these tissues. The lower transport rates appear to result indirectly from changes produced by anesthesia and/or surgery in controllable parameters such as plasma volume and intravascular protein mass.

  14. Bitumen fume-induced gene expression profile in rat lung

    SciTech Connect (OSTI)

    Gate, Laurent [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France)]. E-mail: laurent.gate@inrs.fr; Langlais, Cristina [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Micillino, Jean-Claude [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Nunge, Herve [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Bottin, Marie-Claire [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Wrobel, Richard [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France); Binet, Stephane [Institut National de Recherche et Securite, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex (France)

    2006-08-15T23:59:59.000Z

    Exposure to bitumen fumes during paving and roofing activities may represent an occupational health risk. To date, most of the studies performed on the biological effect of asphalt fumes have been done with regard to their content in carcinogenic polycyclic aromatic hydrocarbons (PAH). In order to gain an additional insight into the mechanisms of action of bitumen fumes, we studied their pulmonary effects in rodents following inhalation using the microarray technology. Fisher 344 rats were exposed for 5 days, 6 h/day to bitumen fumes generated at road paving temperature (170 {sup o}C) using a nose-only exposition device. With the intention of studying the early transcriptional events induced by asphalt fumes, lung tissues were collected immediately following exposure and gene expression profiles in control and exposed rats were determined by using oligonucleotide microarrays. Data analysis revealed that genes involved in lung inflammatory response as well as genes associated with PAH metabolization and detoxification were highly expressed in bitumen-exposed animals. In addition, the expression of genes related to elastase activity and its inhibition which are associated with emphysema was also modulated. More interestingly genes coding for monoamine oxidases A and B involved in the metabolism of neurotransmitters and xenobiotics were downregulated in exposed rats. Altogether, these data give additional information concerning the bitumen fumes biological effects and would allow to better review the health effects of occupational asphalt fumes exposure.

  15. Impacts of the Norway Rat on the auklet breeding colony at Sirius Point, Kiska Island, Alaska in 2003

    E-Print Network [OSTI]

    Jones, Ian L.

    Impacts of the Norway Rat on the auklet breeding colony at Sirius Point, Kiska Island, Alaska of the Norway rat (Rattus norvegicus) onto Kiska Island, Aleutian Islands, Alaska, in the 1940s (Murie 1959 and to investigate the biology and demography of the Norway rat population. Moors and Atkinson (1984) suggested

  16. Auklet Demography and the Influence of Norway rats at Kiska Island report on results of monitoring to 2009

    E-Print Network [OSTI]

    Jones, Ian L.

    Auklet Demography and the Influence of Norway rats at Kiska Island ­ report on results METHODS 4 AUKLET PRODUCTIVITY 4 TIMING OF BREEDING 5 AUKLET SURVIVAL 6 NORWAY RAT ABUNDANCE 10 NORWAY RAT ABUNDANCE AND DISTRIBUTION 10 VEGETATION CHANGES 11 DISCUSSION 11 LEAST AUKLET

  17. Maternal Responsiveness to Infant Norway Rat (Rattus norvegicus) Ultrasonic Vocalizations During the Maternal Behavior Cycle and After

    E-Print Network [OSTI]

    Maternal Responsiveness to Infant Norway Rat (Rattus norvegicus) Ultrasonic Vocalizations During environment, Norway rat (Rattus norvegicus) pups emit ultrasonic vocalizations that can elicit maternal search is particularly important in altricial species such as the Norway rat in which infants rely on the mother

  18. ECOLOGY OF NORWAY RATS (RATTUS NORVEGICUS) IN RELATION TO CONSERVATION AND MANAGEMENT OF SEABIRDS ON KISKA ISLAND,

    E-Print Network [OSTI]

    Jones, Ian L.

    ECOLOGY OF NORWAY RATS (RATTUS NORVEGICUS) IN RELATION TO CONSERVATION AND MANAGEMENT OF SEABIRDS to predation by introduced Norway rats (Rattus norvegicus). In 2001 and 2002 the auklet colony experienced the lowest reproductive success ever recorded for auklets. Norway rats have been suggested as the cause

  19. Activation of orexin signal in basal forebrain facilitates the emergence from sevoflurane anesthesia in rat

    E-Print Network [OSTI]

    anesthesia in rat Hailong Dong 1 , Jiyuan Niu 1 , Binxiao Su, Zhenghua Zhu, Yan Lv, Yizhi Li, Lize Xiong t Orexinergic system may play an important role in the regulation of anesthesia­arousal. However, which region, induction and emergence time to sevoflurane anesthesia in rats. Either orexin-A or orexin-B was injected

  20. Relaxation Time Constants and Apparent Diffusion Coefficients of Rat Retina at 7 Tesla

    E-Print Network [OSTI]

    Duong, Timothy Q.

    Relaxation Time Constants and Apparent Diffusion Coefficients of Rat Retina at 7 Tesla Govind Nair* and ADC of the rat eyes were measured at 50 3 50 3 800 lm at 7 Tesla. Profiles of T1, T2, T2* and ADC

  1. Effect of Two Models of Intrauterine Growth Restriction on Alveolarization in Rat Lungs: Morphometric and Gene

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Effect of Two Models of Intrauterine Growth Restriction on Alveolarization in Rat Lungs L-NAME impairs lung development before alveolarization. Known growth factors involved in lung on Alveolarization in Rat Lungs: Morphometric and Gene Expression Analysis. PLoS ONE 8(11): e78326. doi:10

  2. Endogenous opioids and attenuated hypothalamic-pituitary-adrenal axis responses to immune challenge in pregnant rats 

    E-Print Network [OSTI]

    Russell, J. A.; Ochedalski, T; Meddle, S. L.; Ma, S.; Brunton, P. J.; Douglas, A. J.

    2005-01-01T23:59:59.000Z

    , but not pregnant, rats. However, naloxone infused directly into the PVN increased noradrenaline release after IL-1{beta} in pregnant rats. Thus, the HPA axis responses to immune signals are suppressed in pregnancy at the level of pPVN CRH neurons through an opioid...

  3. Experimental and theoretical studies of oxygen gradients in rat pial microvessels

    E-Print Network [OSTI]

    Popel, Aleksander S.

    no substantial impact on the transmural PO2 gradient. Journal of Cerebral Blood Flow & Metabolism (2008) 28, 1597Experimental and theoretical studies of oxygen gradients in rat pial microvessels Maithili Sharan1 near cortical arterioles and transmural PO2 gradients in the pial arterioles of the rat. Under control

  4. The Effects of Alcohol and Age on Astrocytes In Female Rats Following an Inflammatory Stimulus

    E-Print Network [OSTI]

    Simpson, Ashley

    2009-09-30T23:59:59.000Z

    THE EFFECTS OF ALCOHOL AND AGE ON ASTROCYTES IN FEMALE RATS FOLLOWING AN INFLAMMATORY STIMULUS A Senior Scholars Thesis by ASHLEY NICOLE SIMPSON Submitted to the Office of Undergraduate Research Texas A...&M University In partial fulfillment of the requirements for the designation as UNDERGRADUATE RESEARCH SCHOLAR April 2006 Major: Biology THE EFFECTS OF ALCOHOL AND AGE ON ASTROCYTES IN FEMALE RATS FOLLOWING...

  5. Research Report Effects of ethanol consumption by adult female rats on subsequent

    E-Print Network [OSTI]

    Galef Jr., Bennett G.

    Research Report Effects of ethanol consumption by adult female rats on subsequent consumption January 2004 Abstract We used a two-bottle choice test to measure voluntary ethanol consumption by adolescent rats that had lived with ethanol-consuming or water-consuming adult conspecifics. We found

  6. The harmful effects of late-onset alcohol consumption on cortical bone in aged rats

    E-Print Network [OSTI]

    Bowlin, Julie Lee

    2001-01-01T23:59:59.000Z

    This study looked at the effects of late-onset alcohol consumption for 8 weeks on the aged rat model (15 months old). Thirty 15 month old female Fisher 344 rats were divided into three diet groups: Alcohol (n=9), pair-fed (n=9), and pellet (n=6...

  7. Water balance in rats exposed to chronic centrifugation RUDY M. ORTIZ AND CHARLES E. WADE

    E-Print Network [OSTI]

    Ortiz, Rudy M.

    was observed, the lack of a change in %TBW among the three measurement periods or in water flux over the 12Water balance in rats exposed to chronic centrifugation RUDY M. ORTIZ AND CHARLES E. WADE Life; accepted in final form 22 February 2000 Ortiz, Rudy M., and Charles E. Wade. Water balance in rats exposed

  8. Prefrontal involvement in the regulation of emotion: convergence of rat and human studies

    E-Print Network [OSTI]

    Quirk, Gregory J.

    experiments designed to bridge human and rodent models of emotion regulation. Addresses 1 Department of prefrontal involvement of emotion regula- tion using rat and human models, and suggest future experimentsPrefrontal involvement in the regulation of emotion: convergence of rat and human studies Gregory J

  9. PMSG responsiveness during adult life after partial oogonia destruction with misulban in the rat embryo

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    sensitive to X-ray irradiation in the last period of division, i.e. about day 15 of pregnancy in the rat-month old female rats were bred under standard conditions of light (14 h light―10 h dark) and food

  10. Lung and alveolar wall elastic and hysteretic behavior in rats: effects of in vivo elastase treatment

    E-Print Network [OSTI]

    Lutchen, Kenneth

    Lung and alveolar wall elastic and hysteretic behavior in rats: effects of in vivo elastase P. Ingenito, and Be´la Suki. Lung and alveolar wall elastic and hysteretic behavior in rats: effects behavior of the alveolar walls and the macroscopic mechanical properties of the whole lung in an in vivo

  11. Plasticity in the Rat Posterior Auditory Field Following Nucleus Basalis Stimulation

    E-Print Network [OSTI]

    Kilgard, Michael P.

    Plasticity in the Rat Posterior Auditory Field Following Nucleus Basalis Stimulation Amanda C. Plasticity in the rat posterior auditory field following nucleus basalis stimulation. J Neurophysiol 98: 253 have been shown to cause frequency-specific plasticity in both primary and secondary cortical areas

  12. Impedance measurements of ex vivo rat lung at different volumes of inflation

    E-Print Network [OSTI]

    Illinois at Urbana-Champaign, University of

    Impedance measurements of ex vivo rat lung at different volumes of inflation Michael L. Oelze that the occurrence of ultrasonically induced lung hemorrhage in rats was directly correlated to the level of lung inflation. In that study, it was hypothesized that the lung could be modeled as two components consisting

  13. Catheterization of the Hepatic Artery Via the Left Common Carotid Artery in Rats

    SciTech Connect (OSTI)

    Li Xiao [West China Hospital, Sichuan University, Department of Radiology (China); Wang Yixiang, J. [AstraZeneca R and D (United Kingdom); Zhou Xiangping [West China Hospital, Sichuan University, Department of Radiology (China)], E-mail: xiangpingzhou46@163.com; Guan Yongsong; Tang Chengwei [West China Hospital, Sichuan University, Department of Gastroenterology (China)

    2006-12-15T23:59:59.000Z

    The commonly used approach for rat hepatic artery catheterization is via the gastroduodenal artery, which is ligated after the procedure. A new method of rat hepatic artery catheterization via the left common carotid artery (LCCA) is described. The LCCA is repaired after catheterization. The catheterization procedures included the following: (1) opening the rat's abdominal cavity and exposing the portion of abdominal aorta at the level of the celiac trunk; (2) separating and exposing the LCCA; inserting a microguidewire and microcatheter set into the LCCA via an incision; after placement into the descending aorta, the microguidewire and microcatheter are maneuvered into the hepatic artery under direct vision; (3) after transcatheter therapy, the catheter is withdrawn and the incision at the LCCA is repaired. This technique was employed on 60 male Sprague-Dawley rats with diethylnitrosamine-induced liver cancer, using a 3F microguidewire and microcatheter set. Selective hepatic artery catheterization was successfully performed in 57 rats. One rat died during the operation and five rats died within 7 days after the procedure. It is envisaged that as experience increases, the catheterization success rate will increase and the death rate will decrease. A new approach for selective hepatic artery catheterization via the LCCA in rats is introduced, which makes repeat catheterization of this artery possible and allows large embolization particles to be delivered by using a 3F catheter.

  14. Proteomic analysis of rat cerebral cortex following subchronic acrolein toxicity

    SciTech Connect (OSTI)

    Rashedinia, Marzieh; Lari, Parisa [Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad (Iran, Islamic Republic of); Abnous, Khalil, E-mail: Abnouskh@mums.ac.r [Pharmaceutical Research Center, Department of Medicinal Chemistry, Mashhad University of Medical Sciences, Mashhad (Iran, Islamic Republic of); Hosseinzadeh, Hossein, E-mail: Hosseinzadehh@mums.ac.ir [Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad (Iran, Islamic Republic of)

    2013-10-01T23:59:59.000Z

    Acrolein, a member of reactive ?,?-unsaturated aldehydes, is a major environmental pollutant. Acrolein is also produced endogenously as a toxic by-product of lipid peroxidation. Because of high reactivity, acrolein may mediate oxidative damages to cells and tissues. It has been shown to be involved in a wide variety of pathological states including pulmonary, atherosclerosis and neurodegenerative diseases. In this study we employed proteomics approach to investigate the effects of subchronic oral exposures to 3 mg/kg of acrolein on protein expression profile in the brain of rats. Moreover effects of acrolein on malondialdehyde (MDA) levels and reduced glutathione (GSH) content were investigated. Our results revealed that treatment with acrolein changed levels of several proteins in diverse physiological process including energy metabolism, cell communication and transport, response to stimulus and metabolic process. Interestingly, several differentially over-expressed proteins, including ?-synuclein, enolase and calcineurin, are known to be associated with human neurodegenerative diseases. Changes in the levels of some proteins were confirmed by Western blot. Moreover, acrolein increases the level of MDA, as a lipid peroxidation biomarker and decreased GSH concentrations, as a non-enzyme antioxidant in the brain of acrolein treated rats. These findings suggested that acrolein induces the oxidative stress and lipid peroxidation in the brain, and so that may contribute to the pathophysiology of neurological disorders. - Highlights: • Acrolein intoxication increased lipid peroxidation and deplete GSH in rat brain. • Effect of acrolein on protein levels of cerebral cortex was analyzed by 2DE-PAGE. • Levels of a number of proteins with different biological functions were increased.

  15. The oncogenic action of ionizing radiation on rat skin

    SciTech Connect (OSTI)

    Burns, F.J.; Garte, S.J.

    1992-01-01T23:59:59.000Z

    The multistage theory of carcinogenesis specifies that cells progress to cancer through a series of discrete, irreversible genetic alterations, but data on radiation-induced cancer incidence in rat skin suggests that an intermediate repairable alteration may occur. Data are presented on cancer induction in rat skin exposed to an electron beam (LET=0.34 keV/[mu]), a neon ion beam (LET=45) or an argon ion beam (LET=125). The rats were observed for tumors at least 78 weeks with squamous and basal cell carcinomas observed. The total cancer yield was fitted by the quadratic equation, and the equation parameters were estimated by linear regression for each type of radiation. Analysis of the DNA from the electron-induced carcinomas indicated that K-ras and/or c-myc oncogenes were activated. In situ hybridization indicated that the cancers contain subpopulations of cells with differing amounts of c-myc and H-ras amplification. The results are consistent with the idea that ionizing radiation produces stable, carcinogenically relevant lesions via 2 repairable events at low LET and via a non-repairable linked event pathway at high LET; either pathway may advance the cell by 1 stage. The proliferative response of rat epidermis following exposure to ionizing radiation was quantified by injection of [sup 14]C-thymidine. The return of these cells to S-phase a second time was detected by a second label ([sup 3]H). When the labeled cells were in G1-phase, the dorsal skin was irradiated with X-rays. All labeling indices were determined. The [sup 14]C labeling index was constant and unaffected by the radiation. The proportion of all cells entering S-phase averaged 3.5% at 18 hr and increased after 44, 52 and 75 hr to average levels of 11.8%, 5. 3%, and 6.6% at 0, 10 and 25 Gy respectively. The proportion of S-phase cells labeled with [sup 14]C increased after 42 hr and remained relatively constant thereafter.

  16. The effects of alcohol and irradiation on the albino rat 

    E-Print Network [OSTI]

    Klobukowski, Christopher John

    1963-01-01T23:59:59.000Z

    '&eight During the Test I'eriod. lh Combined. Daily Caloric Intake - Ca- lories per 100 Grams of 3ody Ueight. 17 Survival '?ata and Peak Death Days 3xpt. II. Surv1 vBI Data and Peek !3ea'l h Days Sxpte Ilia 3 j& Average Dody "? eights ( Pram... ~ ) ?" i rat Day I'ostirradiation. Average Pluid Intake (in millili gers) per 100 Grams of Dody Ueight, T~so Dave Pre-, Three ?Days Postirradiafion, "?S Average Percent ?ge of Total Caloric lntal:e per 100 Grams of 3od. , ? '?eight Supplied. 'by...

  17. Organization and evolution of the rat tyrosine hydroxylase gene

    SciTech Connect (OSTI)

    Brown, E.R.; Coker, G.T. III; O'Malley, K.L.

    1987-08-11T23:59:59.000Z

    This report describes the organization of the rat tyrosine hydroxylase (TH) gene and compares its structure with the human phenylalanine hydroxylase gene. Both genes are single copy and contain 13 exons separated by 12 introns. Remarkably, the positions of 10 out 12 intron/exon boundaries are identical for the two genes. These results support the idea that these hydroxylases genes are members of a gene family which has a common evolutionary origin. The authors predict that this ancestral gene would have encoded exons similar to those of TH prior to evolutionary drift to other members of this gene family.

  18. Magnetic and dielectric behavior of the spin-chain compound Er{sub 2}BaNiO{sub 5} well below its Néel temperature

    SciTech Connect (OSTI)

    Basu, Tathamay; Singh, Kiran; Sampathkumaran, E. V. [Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400005 (India); Mohapatra, N. [School of Basic Sciences, Indian Institute of Technology Bhubaneshwar, Bhubaneshwar 751013 (India)

    2014-09-21T23:59:59.000Z

    We have recently reported that the Haldane spin-chain system, Er{sub 2}BaNiO{sub 5}, undergoing antiferromagnetic order below (T{sub N}=) 32?K, is characterized by the onset of ferroelectricity near 60?K due to magnetoelectric coupling induced by short-range magnetic-order within spin-chains. We have carried out additional magnetic and dielectric studies to understand the properties well below T{sub N}. We emphasize here on the following: (i) A strong frequency dependent behaviors of ac magnetic susceptibility and complex dielectric properties have been observed at much lower temperatures (<8?K), that is, “reentrant multiglass-like” phenomenon, naturally suggesting the existence of an additional transition well below T{sub N}. (ii) “Magnetoelectric phase coexistence” is observed at very low temperature (e.g., T?=?2?K), where the high-field magnetoelectric phase is partially arrested on returning to zero magnetic field after a cycling through metamagnetic transition.

  19. Structural and thermoelectric properties of BaRCo{sub 4}O{sub 7} (R = Dy, Ho, Er, Tm, Yb, and Lu)

    SciTech Connect (OSTI)

    Wong-Ng, W.; Yan, Y.; Liu, G. [Ceramics Division, NIST, Gaithersburg, Maryland 20899 (United States); Xie, W.; Tritt, T. [Department of Physics, Clemson University, Greensville, South Carolina 29634 (United States); Kaduk, J. [Illinois Institute of Technology, Chicago, Illinois 60616 (United States); Thomas, E. [Air Force Research Laboratory, Wright Pattersen, Ohio 45433 (United States)

    2011-12-01T23:59:59.000Z

    The structure and thermoelectric properties of a series of barium lanthanide cobaltites, BaRCo{sub 4}O{sub 7} (R = Dy, Ho, Er, Tm, Yb, and Lu), which were prepared using the spark plasma synthesis technique, have been investigated. The space group of these compounds was re-determined and confirmed to be P31c instead of the reported P6{sub 3}mc. The lattice parameters a and c range from 6.26279(2) Angst to 6.31181(6) Angst , and from 10.22468(6) Angst to 10.24446(15) Angst for R = Lu to Dy, respectively. The crystal structure of BaRCo{sub 4}O{sub 7} is built up from Kagome sheets of CoO{sub 4} tetrahedra, linked by triangular layers of CoO{sub 4} tetrahedra. The values of figure of merit (ZT) of the BaRCo{sub 4}O{sub 7} samples were determined to be around 0.02 at 800 K. X-ray diffraction patterns of these samples have been determined and submitted to the Powder Diffraction File.

  20. Radiation leukaemogenesis at low doses DE-FG02-05 ER 63947 Final Technical Report 15 May 2005 â?? 14 May 2010

    SciTech Connect (OSTI)

    Simon Bouffler; Christophe Badie; Natalie Brown; Rosemary Finnon

    2010-07-28T23:59:59.000Z

    This report provides a full summary of the results obtained under grant DE-FG02-05ER63947, Radiation Leukaemogenesis at low doses. The studies employed an experimental model of radiation leukaemogenesis with the main aim of identifying key events that convert normal cells into leukaemic cells follwoing exposure to radiation. Important aspect of the work was to understand dose-response relationships and time course relationships for leakaemogenis events. The studies performed provided evidence for direct radiation-induced losses of the Sfpi1/PU.1 gene being critical for induction of the disease. No threshold below 0.1 Gy in the induction of the gene losses was observed. The critical cell type in which the myeloid lekaemias arise has been identified and point mutations in the Sfpi1/PU.1 gene are common in leukaemias. The consequences of the genetic losses and mutation have been examined and these provide evidence of a disruption of differentiation in leukaemic cells. Additional pathways to leukaemogenesis have been identified also. Overall the study provides quantitiative data suitable for testing approaches to modelling of leukaemia rosk at low doses.

  1. Fine tunable red-green upconversion luminescence from glass ceramic containing 5%Er{sup 3+}:NaYF{sub 4} nanocrystals under excitation of two near infrared femtosecond lasers

    SciTech Connect (OSTI)

    Shang, Xiaoying; Cheng, Wenjing; Zhou, Kan; Ma, Jing; Feng, Donghai; Zhang, Shian; Sun, Zhenrong; Jia, Tianqing, E-mail: tqjia@phy.ecnu.edu.cn [State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai 200062 (China); Chen, Ping; Qiu, Jianrong [State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027 (China)

    2014-08-14T23:59:59.000Z

    In this paper, we report fine tunable red-green upconversion luminescence of glass ceramic containing 5%Er{sup 3+}: NaYF{sub 4} nanocrystals excited simultaneously by two near infrared femtosecond lasers. When the glass ceramic was irradiated by 800?nm femtosecond laser, weak red emission centered at 670?nm was detected. Bright red light was observed when the fs laser wavelength was tuned to 1490?nm. However, when excited by the two fs lasers simultaneously, the sample emitted bright green light centered at 550?nm, while the red light kept the same intensity. The dependences of the red and the green light intensities on the two pump lasers are much different, which enables us to manipulate the color emission by adjusting the two pump laser intensities, respectively. We present a theoretical model of Er{sup 3+} ions interacting with two fs laser fields, and explain well the experimental results.

  2. Upconversion and pump saturation mechanisms in Er{sup 3+}/Yb{sup 3+} co-doped Y{sub 2}Ti{sub 2}O{sub 7} nanocrystals

    SciTech Connect (OSTI)

    Wang, Fengxiao; Song, Feng, E-mail: fsong@nankai.edu.cn; Zhang, Gong; Han, Yingdong; Li, Qiong; Tian, Jianguo [School of Physics, Nankai University, Tianjin 300071 (China); The Key Laboratory of Weak Light Nonlinear Photonics, Ministry of Education, Nankai University, Tianjin 300457 (China); Ming, Chengguo [The Key Laboratory of Weak Light Nonlinear Photonics, Ministry of Education, Nankai University, Tianjin 300457 (China); Physics Department, School of Sciences, Tianjin University of Science and Technology, Tianjin 300457 (China)

    2014-04-07T23:59:59.000Z

    The Er{sup 3+}/Yb{sup 3+} co-doped Y{sub 2}Ti{sub 2}O{sub 7} nanocrystals were synthesized by the sol–gel method. X-ray diffraction, transmission electronic microscopy, and photoluminescence spectra were measured to verify the Y{sub 2}Ti{sub 2}O{sub 7} nanocrystalline produced in the sample annealed at 800?°C. The anomalous slopes of the fitted line in the log-log plots for upconversion emissions and the pump-saturation effect of near-infrared emission were observed in the nanocrystalline samples. A theoretical model of practical Er{sup 3+}/Yb{sup 3+} co-doped system based on the rate equations were put forward and explained the experimental phenomena well.

  3. Watt-level, all-fiber, ultrafast Er/Yb-codoped double-clad fiber laser mode-locked by reduced graphene oxide interacting with a weak evanescent field

    E-Print Network [OSTI]

    Gao, Lei; Li, Yujia

    2015-01-01T23:59:59.000Z

    We propose a Watt-level, all-fiber, ultrafast Er/Yb-codoped double-clad fiber laser passively mode-locked by reduced graphene oxide (rGO) interacting with a weak evanescent field of photonic crystal fiber (PCF). The rGO solution is filled into the cladding holes of the PCF based on total reflection, and after evaporation, the rGO flakes bear only 1/107 of the total energy in laser system, which enhances the thermal damage threshold and decreases the accumulated nonlinearity. By incorporating the saturable absorber into an Er/Yb-codoped fiber ring cavity, stable conventional soliton with a duration of 573 fs is generated, and a average output power up to 1.14 W is obtained.

  4. 891070-9932/142014IEEE sEptEmbEr 2014 IEEE rObOtICs & AUtOmAtION mAGAZINE By Yaroslav Tenzer, Leif P. Jentoft, and Robert D. Howe

    E-Print Network [OSTI]

    891070-9932/14©2014IEEE sEptEmbEr 2014 · IEEE rObOtICs & AUtOmAtION mAGAZINE · The Feel of MEMS available for a wide range of robotics and human-interface applications. Background Tactile sensing, such as the location of object contacts on the robot hand and contact pressure distribution, are believed

  5. Ag{sub 2}O dependent up-conversion luminescence properties in Tm{sup 3+}/Er{sup 3+}/Yb{sup 3+} co-doped oxyfluorogermanate glasses

    SciTech Connect (OSTI)

    Hu, Yuebo [Faculty of Mechanical and Electrical Engineering, Kunming University of Science and Technology, Kunming 650500 (China); Qiu, Jianbei, E-mail: qiu@kmust.edu.cn; Song, Zhiguo; Zhou, Dacheng [Key Laboratory of Advanced Materials in Rare and Precious and Non-ferrous Metals, Ministry of Education, Key Laboratory of Advanced Materials of Yunnan Province, Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093 (China)

    2014-02-28T23:59:59.000Z

    Up-conversion (UC) luminescence properties of Ag/Tm{sup 3+}/Er{sup 3+}/Yb{sup 3+} co-doped oxyfluorogermanate glasses have been studied to assess the effective role of silver nanoparticles as a sensitizer for Tm{sup 3+} and Er{sup 3+} ions. The X-ray diffraction patterns obtained in this work do not reveal any crystalline phase in the glass. However, the absorption spectra reveal that surface plasmons resonance band of Ag undergoes a distinct split with two maxima and a very broad absorption peak with a background that extends toward the near infrared (NIR) with the increasing of Ag{sub 2}O added concentration. Transmission electron microscope images confirm that silver nanoparticles have been precipitated from matrix glasses and show their distribution, size, and shapes. In addition, changes in UC luminescence intensity of four emission bands 476, 524, 546, and 658?nm corresponding to {sup 1}G{sub 4} ? {sup 3}H{sub 6} (Tm{sup 3+}), ({sup 2}H{sub 11/2}, {sup 4}S{sub 3/2}) ? {sup 4}I{sub 15/2} (Er{sup 3+}), and {sup 4}F{sub 9/2} ? {sup 4}I{sub 15/2} (Er{sup 3+}) transitions, respectively, as a function of silver addition to the base composition have been measured under 980?nm excitation. It is confirmed that Ag{sub 2}O added concentration plays an important role in increasing the UC luminescence intensity; however, further increase in Ag{sub 2}O added concentration reduces the intensity.

  6. Bifunction in Er{sup 3+}/Yb{sup 3+} co-doped BaTi{sub 2}O{sub 5}–Gd{sub 2}O{sub 3} glasses prepared by aerodynamic levitation method

    SciTech Connect (OSTI)

    Zhang, Minghui [State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050 (China); University of Chinese Academy of Sciences, Beijing 100039 (China); Yu, Jianding; Pan, Xiuhong [State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050 (China); Cheng, Yuxing [State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050 (China); University of Chinese Academy of Sciences, Beijing 100039 (China); Liu, Yan, E-mail: liuyan@mail.sic.ac.cn [State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050 (China)

    2013-11-15T23:59:59.000Z

    Graphical abstract: - Highlights: • Novel BaTi{sub 2}O{sub 5}–Gd{sub 2}O{sub 3} based glasses have been prepared by aerodynamic levitation. • The obtained glasses show high thermal stability with T{sub g} = 763.3 °C. • Er{sup 3+}/Yb{sup 3+} co-doped glasses show strong upconversion based on a two-photon process. • Red emission is stronger than green emissions for EBT by high Yb{sup 3+} concentration. • Magnetic ions are paramagnetic and the distribution is homogeneous in the glasses. - Abstract: Novel Er{sup 3+}/Yb{sup 3+} co-doped BaTi{sub 2}O{sub 5}–Gd{sub 2}O{sub 3} spherical glasses have been fabricated by aerodynamic levitation method. The thermal stability, upconversion luminescence, and magnetic properties of the present glass have been studied. The glasses show high thermal stability with 763.3 °C of the onset temperature of the glass transition. Red and green emissions centered at 671 nm, 548 nm and 535 nm are obtained at 980 nm excitation. The upconversion is based on a two-photon process by energy transfer, excited-state absorption, and energy back transfer. Yb{sup 3+} ions are more than Er{sup 3+} ions in the glass, resulting in efficient energy back transfer from Er{sup 3+} to Yb{sup 3+}. So the red emission is stronger than the green emissions. Magnetization curves indicate that magnetic rare earth ions are paramagnetic and the distribution is homogeneous and random in the glass matrix. Aerodynamic levitation method is an efficient way to prepare glasses with homogeneous rare earth ions.

  7. Influence of core size on the upconversion luminescence properties of spherical Gd{sub 2}O{sub 3}:Yb{sup 3+}/Er{sup 3+}@SiO{sub 2} particles with core-shell structures

    SciTech Connect (OSTI)

    Zheng, Kezhi; Liu, Zhenyu; Liu, Ye; Song, Weiye; Qin, Weiping, E-mail: wpqin@jlu.edu.cn [State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012 (China)

    2013-11-14T23:59:59.000Z

    Spherical SiO{sub 2} particles with different sizes (30, 80, 120, and 180?nm) have been coated with Gd{sub 2}O{sub 3}:Yb{sup 3+}/Er{sup 3+} layers by a heterogeneous precipitation method, leading to the formation of core-shell structural Gd{sub 2}O{sub 3}:Yb{sup 3+}/Er{sup 3+}@SiO{sub 2} particles. The samples were characterized by using X-ray diffraction, field emission scanning electron microscopy, transmission electron microscopy, upconversion (UC) emission spectra, and fluorescent dynamical analysis. The obtained core-shell particles have perfect spherical shape with narrow size distribution. Under the excitation of 980?nm diode laser, the core-shell samples showed size-dependent upconversion luminescence (UCL) properties. The inner SiO{sub 2} cores in core-shell samples were proved to have limited effect on the total UCL intensities of Er{sup 3+} ions. The UCL intensities of core-shell particles were demonstrated much higher than the values obtained in pure Gd{sub 2}O{sub 3}:Yb{sup 3+}/Er{sup 3+} with the same phosphor volume. The dependence of the specific area of a UCL shell on the size of its inner SiO{sub 2} particle was calculated and analyzed for the first time. It was confirmed that the surface effect came from the outer surfaces of emitting shells is dominant in influencing the UCL property in the core-shell samples. Three-photon UC processes for the green emissions were observed in the samples with small sizes of SiO{sub 2} cores. The results of dynamical analysis illustrated that more nonradiative relaxation occurred in the core-shell samples with smaller SiO{sub 2} core sizes.

  8. Analysis of Hydraulic Responses from the ER-6-1 Multiple-Well Aquifer Test, Yucca Flat FY 2004 Testing Program, Nevada Test Site, Nye County, Nevada, Rev. No.: 0

    SciTech Connect (OSTI)

    Greg Ruskauff

    2005-06-01T23:59:59.000Z

    This report documents the interpretation and analysis of the hydraulic data collected for the Fiscal Year (FY) 2004 Multiple-Well Aquifer Test-Tracer Test (MWAT-TT) conducted at the ER-6-1 Well Cluster in Yucca Flat Corrective Action Unit (CAU) 97, on the Nevada Test Site (NTS). The MWAT-TT was performed to investigate CAU-scale groundwater flow and transport processes related to the transport of radionuclides from sources on the NTS through the Lower Carbonate Aquifer (LCA) Hydrostratigraphic Unit (HSU). The ER-6-1 MWAT-TT was planned and executed by contractor participants for the Underground Test Area (UGTA) Project of the Environmental Restoration (ER) program of the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office (NNSA/NSO). Participants included Stoller-Navarro Joint Venture (SNJV), the Environmental Engineering Services Contractor; Bechtel Nevada (BN); the Desert Research Institute (DRI); Los Alamos National Laboratory; and the University of Nevada, Las Vegas-Harry Reid Center. The SNJV team consists of the S.M. Stoller Corporation, Navarro Research and Engineering, Battelle Memorial Institute, INTERA Inc., and Weston Solutions, Inc. The MWAT-TT was implemented according to the ''Underground Test Area Project, ER-6-1 Multi-Well Aquifer Test - Tracer Test Plan'' (SNJV, 2004a) issued in April 2004. The objective of the aquifer test was to determine flow processes and local hydraulic properties for the LCA through long-term constant-rate pumping at the well cluster. This objective was to be achieved in conjunction with detailed sampling of the composite tracer breakthrough at the pumping well, as well as with depth-specific sampling and logging at multiple wells, to provide information for the depth-discrete analysis of formation hydraulic properties, particularly with regard to fracture properties.

  9. Effect of anesthesia on glucose production and utilization in rats

    SciTech Connect (OSTI)

    Penicaud, L.; Ferre, P.; Kande, J.; Leturque, A.; Issad, T.; Girard, J.

    1987-03-01T23:59:59.000Z

    This study was undertaken to determine the effects of pentobarbital anesthesia (50 mg/kg ip) on glucose kinetics and individual tissue glucose utilization in vivo, in chronically catheterized rats. Glucose turnover studies were carried out using (3-/sup 3/H) glucose as tracer. A transient hyperglycemia and an increased glucose production were observed 3 min after induction of anesthesia. However, 40 min after induction of anesthesia, glycemia returned to the level observed in awake animals, whereas glucose turnover was decreased by 30% as compared with unanesthetized rats. These results are discussed with regard to the variations observed in plasma insulin, glucagon, and catecholamine levels. Glucose utilization by individual tissues was studied by the 2-(1-/sup 3/H) deoxyglucose technique. A four- to fivefold decrease in glucose utilization was observed in postural muscles (soleus and adductor longus), while in other nonpostural muscles (epitrochlearis, tibialis anterior, extensor digitorum longus, and diaphragm) and other tissues (white and brown adipose tissues) anesthesia did not modify the rate of glucose utilization. A decrease in glucose utilization was also observed in the brain.

  10. A study of the nutritive value of sorghum grain with rats

    E-Print Network [OSTI]

    Dohm, Carolee Kathryn

    1969-01-01T23:59:59.000Z

    and Levels of Protein and Amino Acids Response of Rats Fed Sorghum Grain Basal Diets With Individual Supplemental Amino Acids Omitted I. imiting Amino Acids of Sorghum Grain Protein (Rartin) Determined by Chemical Analysis, Rat Growth and by Plasma... for the s?mino acid analysis. Experi???ent 1 The f?. rst e& perimcnt was ccnducted to obtain necessary pri- lin. inary irinmnatiori on the ability of sorghum grain alone nd supplemented with prot. ein or amino acids to promote growth of. i?eanling rats...

  11. Final Report: Novel nanowires as probes of electron coherence and correlations in restricted geometries (DE-FG03-01ER45946)

    SciTech Connect (OSTI)

    Douglas Natelson

    2005-05-17T23:59:59.000Z

    This is a final summary report of the research conducted under DE-FG03-01ER45946, which was a research program using metal nanostructures to examine quantum coherence of electrons in normal and ferromagnetic metals. This program was the PI's first federal research grant, and by augmenting with other funds (Packard Foundation), this grant supported two graduate students during its duration. In normal metal nanostructures, quantum coherence was assessed by two independent techniques: weak localization magnetoresistance, and time-dependent universal conductance fluctuations (TDUCF noise). This work found that, in AuPd nanowires, the coherence information inferred from these two techniques were quantitatively consistent, even in the presence of magnetic impurity and phonon scattering. This confirmed theoretical expectations. However, in Ag and Au wires, the two techniques disagree, with noise measurements indicating a lower coherence length at low temperatures than weak localization. We have a candidate explanation for this, and are finishing these experiments. This work shows that subtleties remain in our understanding of coherence processes even in normal metals, particularly those involving the tunneling two-level systems that produce low frequency noise; this has relevance for quantum information processing implementations using metal devices. We have also studied time-dependent universal conductance fluctuations in ferromagnetic metals for the first time. The TDUCF in ferromagnetic nanowires show that the Cooperon channel of coherent processes is suppressed in these correlated materials. Furthermore, the surprisingly steep temperature dependence of the noise suggests that decoherence in these systems is through a different process than in normal metals. We are finishing measurements of ``magnetofingerprint'' conductance fluctuations in ferromagnetic metals to examine this unusual temperature dependence with an independent technique. This program has produced three papers (one Phys. Rev. B Rapid Communication, one PRB Brief Report, and a longer PRB article), with two more in preparation; it has also resulted in six APS contributed talks by students, and two invited seminars by the PI.

  12. The effect of Zoledronate treatment timing on lumbar and caudal vertebrae in ovariectomized rats

    E-Print Network [OSTI]

    Ruchelsman, Michal (Michal Aliza)

    2007-01-01T23:59:59.000Z

    Introduction: While there have been numerous studies demonstrating the effect of bisphosphonates in rats as either a preventative treatment or recovering treatment for osteoporosis, few have directly compared the two ...

  13. Skeletal Response to Simulated Microgravity Exposures and Exercise in the Adult Rat Model 

    E-Print Network [OSTI]

    Shirazi-Fard, Yasaman

    2013-04-29T23:59:59.000Z

    mass, structure, and integrity and not an accurate predictor of fracture risk. Therefore, it is essential to measure the mechanical properties of bone tissue directly using animal models. The hindlimb unloaded (HU) rat model is a well-established ground...

  14. Beneficial effects of dietary L-arginine supplementation to diabetic rats

    E-Print Network [OSTI]

    Kohli, Ripla

    2004-09-30T23:59:59.000Z

    Diabetic rats exhibit decrease in plasma arginine, NO synthesis and tetrahydrobiopterin in endothelial cells (EC). Treatment with L-arginine may be beneficial for enhancing NO synthesis in diseases associated with endothelial dysfunction. However...

  15. The impact of binge drinking on the young growing female rat skeleton

    E-Print Network [OSTI]

    Gallagher, Sharon Lee

    1997-01-01T23:59:59.000Z

    Previous research indicated that chronic alcohol consumption has a detrimental impact on the skeleton in both humans and alcohol-fed rats. The decreased bone mass seen in alcoholics increases their risk for fractures over time and likely contributes...

  16. E-Print Network 3.0 - anesthetized lactating rats Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in situ and force in the rat plantaris muscle during repeated Effect of lactate infusion on M... .physiology.orgDownloadedfrom 12;Effect of lactate infusion on M-wave...

  17. Effect of passive and active immunization against somatostatin in growing rats and cattle

    E-Print Network [OSTI]

    Lawrence, Mark Elliott

    1985-01-01T23:59:59.000Z

    found in other cells throughout the gastro- intestinal mucosa, usually in the midzone of the villi (Polak et al. , 1975). Somatostatin is found in hypothalamic as well as extrahypothalamic regions of the rat brain (Epelbaum et al. , 1977). Epelbaum...

  18. Dose Dependent Response to Cyclodextrin Infusion in a Rat Model of Verapamil Toxicity

    E-Print Network [OSTI]

    Mottram, Allan R.; Bryant, Sean M; Aks, Steven E

    2012-01-01T23:59:59.000Z

    time to asystole in rats infused with both verapamil Westernso that the total volume infused was the same across groups,respectively. The group infused with verapamil and SBE-CD in

  19. The impact of binge drinking on the young growing female rat skeleton 

    E-Print Network [OSTI]

    Gallagher, Sharon Lee

    1997-01-01T23:59:59.000Z

    Previous research indicated that chronic alcohol consumption has a detrimental impact on the skeleton in both humans and alcohol-fed rats. The decreased bone mass seen in alcoholics increases their risk for fractures over ...

  20. Quantification of Neuroepithelial Bodies and Their Innervation in Fawn-Hooded and Wistar Rat Lungs

    E-Print Network [OSTI]

    Burnstock, Geoffrey

    Quantification of Neuroepithelial Bodies and Their Innervation in Fawn-Hooded and Wistar Rat Lungs neuroendocrine system (DNES) of the lungs, the neuroendocrine cells of which have been shown to express

  1. Estimating cancellous bone properties of the rat from mechanical testing of the femoral neck 

    E-Print Network [OSTI]

    Groves, Jennifer Ann

    1998-01-01T23:59:59.000Z

    ESTIMATING CANCELLOIJS BONE PROPERTIES OF THE RAT FROM MECHANICAL TESTING OF THE FEMORAL NECK A Thesis by JENNIFER ANN GROVES Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE December 1998 Major Subject: Mechanical Engineering ESTIMATING CANCELLOUS BONE PROPERTIES OF THE RAT FROM MECHANICAL TESTING OF THE FEMORAL NECK A Thesis by JENNIFER ANN GROVES Submitted to Texas Ai8:M University...

  2. Absence of an inhibitory action of prolactin on plasma luteinizing hormone in ovariectomized rats

    E-Print Network [OSTI]

    Owens, Robert Ellis

    1977-01-01T23:59:59.000Z

    ABSENCE OF AN INHIBITORY ACTION OF PROLACTIN ON PLASMA LUTEINIZING HORMONE IN OVARIECTOMIZED RATS A Thesis by ROBERT ELLIS OWENS Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement for the degree... of MASTER OF SCIENCE August 1977 Major Subject: Physiology of Reproduction ABSENCE OF AN INHIBITORY ACTION OF PROLACTIN ON PLASMA LUTEINIZING HORMONE IN OVARIECTOMIZED RATS A Thesis by ROBERT ELLIS OWENS Approved as to style and content by: Chai man...

  3. 3-Methylhistidine excretion as an index of dietary protein adequacy in the rat

    E-Print Network [OSTI]

    Kirby, Rebecca Kay

    1980-01-01T23:59:59.000Z

    3-METHYLHISTIDINE EXCRETION AS AN INDEX OF DIETARY PROTEIiV ADEQUACY IN THE RAT A Thesis by REBECCA KAY KIRBY Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement for the degree of MASTER... OF SCIENCE August 1980 Major Subject: Biochemistry and Biophysics 3-METHYLHISTIDINE EXCRETION AS AN INDEX OF DIETARY PROTEIN ADEQUACY IN THE RAT A Thesis by REBECCA KAY KIRBY Approved as to style and content by: (Chairman of Committee) (Member...

  4. Sodium and potassium levels in the serum of acutely irradiated and non-irradiated rats

    E-Print Network [OSTI]

    Shepherd, David Preston

    1967-01-01T23:59:59.000Z

    SODIUM AND POTASSIUM LEVELS IN THE SERUM OF ACUTELY IRRADIATED AND NON-IRRADIATED RATS A Thesis By DAVID PRESTON SHEPHERD Submitted to the Graduate College of the Texas ARM University in partial fulfillment of the requirements for the degree... of MASTER OF SCIENCE August 1967 Major Subject: Zoology SODIUM AND POTASSIUM LEVELS IN THE SERUM OF ACUTELY IRRADIATED AND NON-IRRADIATED RATS A Thesis By DAVID PRESTON SHEPHERD Approved as to style and content by: (Chairman of Committee) (Head...

  5. The postnatal development of the sex organs in prenatally and early postnatally irradiated male albino rats

    E-Print Network [OSTI]

    Ricks, Robert Clinton

    1964-01-01T23:59:59.000Z

    THE POSTNATAL DEVELOPMENT OF THE SEX ORGANS IN PRENATALLY AND EARLY POSTNATALLY IRRADIATED MALE ALBINO RATS A Thesis By ROBERT C. RICKS Submitted to the Graduate College of the Texas ARM University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE August, 1964 Major Subject: Zoology THE POSTNATAL DEVELOPMENT OF THE SEX ORGANS IN PRENATALLY AND EARLY POSTNATALLY IRRADIATED MALE ALBINO RATS A Thesis By ROBERT C. RICKS Approved as to style and content by...

  6. Magnesium and pyridoxine intake and mineral content of selected tissues and physical development in rats

    E-Print Network [OSTI]

    Edgar, Susan Elaine

    1986-01-01T23:59:59.000Z

    MAGNESIUM AND PYRIDOXINE INTAKE MINERAL CONTENT OF SELECTED TISSUES PHYSICAL DEVELOPMENT IN RATS A Thesis by SU S AN ELA I NE EDGAR Submitted to the Graduate College of Texas A8rM University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE August 1986 Major Subject: Nutrition MAGNESIUM AND PYRIDOXINE INTAKE MINERAL CONTENT OF SELECTED TISSUES PHYS ICAL DEVELOPMENT IN RATS A Thesis by SUSAN ELAINE EDGAR Approved as to style and content by: 'KAREN...

  7. Effects of simulated microgravity on vasoconstrictor and mechanical properties of the rat abdominal aorta

    E-Print Network [OSTI]

    Papadopoulos, Anthony

    2002-01-01T23:59:59.000Z

    EFFECTS OF SIMULATED MICROGRAVITY ON VASOCONSTRICTOR AND MECHANICAL PROPERTIES OF THE RAT ABDOMINAL AORTA A Thesis by ANTHONY PAPADOPOULOS Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE August 2002 Major Subject: Biomedical Engineering EFFECTS OF SIMULATED MICROGRAVITY ON VASOCONSTRICTOR AND MECHANICAL PROPERTIES OF THE RAT ABDOMINAL AORTA A Thesis by ANTHONY PAPADOPOULOS Submitted...

  8. Copper induced osteopenia and its relationship to the development of postmenopausal osteoporosis in the rat

    E-Print Network [OSTI]

    Yee, Cindy Deann

    1992-01-01T23:59:59.000Z

    COPPER INDUCED OSTEOPENIA AND ITS RELATIONSHIP TO THE DEVELOPMENT OF POSTMENOPAUSAL OSTEOPOROSIS IN THE RAT A Thesis CINDY DEANN YEE Submitted to the Office of Graduate Studies of Texas ASM University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE August 1992 Major Subject: Nutrition COPPER INDUCED OSTEOPENIA AND ITS RELATIONSHIP TO THE DEVELOPMENT OF POSTMENOPAUSAL OSTEOPOROSIS IN THE RAT A Thesis CINDY DEANN YEE Approved as to style and content...

  9. LES TYROSINASES CUTANES CHEZ LE RAT. MODIFICATIONS AU COURS DU DVELOPPEMENT

    E-Print Network [OSTI]

    Boyer, Edmond

    LES TYROSINASES CUTAN�ES CHEZ LE RAT. MODIFICATIONS AU COURS DU D�VELOPPEMENT ET PENDANT LE CYCLE Sciences appliquées, 69621 Villeurbanne 1 1 R�SUM� Nous avons effectué l'étude des tyrosinases de la peau chez le Rat. Ces tyrosinases sont mises en évidence, après électrophorèse par réaction de Dopa sur gel

  10. Magnesium deficiency and type of protein during gestation and lactation in rats 

    E-Print Network [OSTI]

    Holmes, Kathryn Ellen Hughes

    1988-01-01T23:59:59.000Z

    MAGNESIUM DEFICIENCY AND TYPE OF PROTEIN DURING GESTATION AND LACTATION IN RATS A Thesis by KATHRYN ELLEN HUGHES HOLMES Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirements for the degree... of MASTER OF SCIENCE August 1988 Major Subject: Nutrition MAGNESIUM DEFICIENCY AND TYPE OF PROTEIN DURING GESTATION AND LACTATION IN RATS A Thesis by KATHRYN ELLEN HUGHES HOLMES Approved as to style and content by: Karen S. Kubena (Chair...

  11. Systematics of the southern races of two species of kangaroo rats (Dipodomys compactus and D. ordi)

    E-Print Network [OSTI]

    Baumgardner, George D

    1979-01-01T23:59:59.000Z

    SYSTEMATICS OF THE SOUTHERN RACES OF TWO SPECIES OF KANGAROO RATS (DIPODOMYS COMPACTUS AND D. ORDI) A Thesis by GEORGE DAVIS BAUMGARDNER Submitted to the Graduate Colleqe of Texas A&M University in partial fulfillment o- the requirement... for the deqree of MASTER OF SCIENCE May 1979 Major Subject: Nildlife and Fisheries Sciences SYSTEMATICS OF THE SOUTHERN RACES OF TWO SPECIES OF KANGAROO RATS (DIPODOMYS COMPACTUS AND D. ORDI) A Thesis by GEORGE DAVIS BAUMGARDNER Approved as to style...

  12. Dose-Response Effect of Charged Carbon Beam on Normal Rat Retina Assessed by Electroretinography

    SciTech Connect (OSTI)

    Mizota, Atsushi, E-mail: mizota-a@med.teikyo-u.ac.j [Department of Ophthalmology, Teikyo University School of Medicine, Tokyo (Japan); Department of Ophthalmology, Juntendo University Urayasu Hospital, Urayasu (Japan); Tanaka, Minoru [Department of Ophthalmology, Juntendo University Urayasu Hospital, Urayasu (Japan); Kubota, Mariko; Negishi, Hisanari [Department of Ophthalmology, National Hospital Organization Chiba Medical Center, Chiba (Japan); Watanabe, Emiko [Department of Ophthalmology, Teikyo University School of Medicine, Tokyo (Japan); Tsuji, Hiroshi; Miyahara, Nobuyuki; Furusawa, Yoshiya [National Institute of Radiological Sciences, Chiba (Japan)

    2010-12-01T23:59:59.000Z

    Purpose: To compare the effects of carbon beam irradiation with those of proton beam irradiation on the physiology of the retina of rats. Methods and Materials: Eight-week-old Wister rats were used. The right eyes were irradiated with carbon beam (1, 2, 4, 8, and 16 Gy) or proton beam (4, 8, 16, and 24 Gy) with the rats under general anesthesia. Electroretinograms were recorded 1, 3, 6, and 12 months after the irradiation, and the amplitudes of the a and b waves were compared with those of control rats. Results: The amplitude of b waves was reduced more than that of a waves at lower irradiation doses with both types of irradiation. With carbon ion irradiation, the amplitudes of the b wave were significantly reduced after radiation doses of 8 and 16 Gy at 6 months and by radiation doses of 4, 8, and 16 Gy at 12 months. With proton beam irradiation, the b-wave amplitudes were significantly reduced after 16 and 24 Gy at 6 months and with doses of 8 Gy or greater at 12 months. For the maximum b-wave amplitude, a significant difference was observed in rats irradiated with carbon beams of 4 Gy or more and with proton beams of 8 Gy or more at 12 months after irradiation. Conclusions: These results indicate that carbon beam irradiation is about two times more damaging than proton beam irradiation on the rat retina at the same dose.

  13. Anti-inflammatory activity of methyl palmitate and ethyl palmitate in different experimental rat models

    SciTech Connect (OSTI)

    Saeed, Noha M. [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo (Egypt)] [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo (Egypt); El-Demerdash, Ebtehal [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt)] [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt); Abdel-Rahman, Hanaa M. [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo (Egypt)] [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo (Egypt); Algandaby, Mardi M. [Department of Biology (Botany), Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia)] [Department of Biology (Botany), Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia); Al-Abbasi, Fahad A. [Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia)] [Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah (Saudi Arabia); Abdel-Naim, Ashraf B., E-mail: abnaim@pharma.asu.edu.eg [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt)

    2012-10-01T23:59:59.000Z

    Methyl palmitate (MP) and ethyl palmitate (EP) are naturally occurring fatty acid esters reported as inflammatory cell inhibitors. In the current study, the potential anti-inflammatory activity of MP and EP was evaluated in different experimental rat models. Results showed that MP and EP caused reduction of carrageenan-induced rat paw edema in addition to diminishing prostaglandin E2 (PGE2) level in the inflammatory exudates. In lipopolysaccharide (LPS)-induced endotoxemia in rats, MP and EP reduced plasma levels of tumor necrosis factor-? (TNF-?) and interleukin-6 (IL-6). MP and EP decreased NF-?B expression in liver and lung tissues and ameliorated histopathological changes caused by LPS. Topical application of MP and EP reduced ear edema induced by croton oil in rats. In the same animal model, MP and EP reduced neutrophil infiltration, as indicated by decreased myeloperoxidase (MPO) activity. In conclusion, this study demonstrates the effectiveness of MP and EP in combating inflammation in several experimental models. -- Highlights: ? Efficacy of MP and EP in combating inflammation was displayed in several models. ? MP and EP reduced carrageenan-induced rat paw edema and prostaglandin E2 level. ? MP and EP decreased TNF-? and IL-6 levels in experimental endotoxemia. ? MP and EP reduced NF-?B expression and histological changes in rat liver and lung. ? MP and EP reduced croton oil-induced ear edema and neutrophil infiltration.

  14. Prolactin and aging: X-irradiated and estrogen-induced rat mammary tumorigenesis

    SciTech Connect (OSTI)

    Ito, A.; Naito, M.; Watanabe, H.; Yokoro, K.

    1984-07-01T23:59:59.000Z

    Both sexes of inbred WF rats at either 8 or 28-60 weeks of age were exposed to 200 rad whole-body radiation, 2.5 or 5.0 mg 17 beta-estradiol (E2), or both agents The female rats treated with E2 alone or with both X-rays and E2 at 8 weeks of age showed a high incidence of mammary carcinomas (MCA), a large increase in pituitary weight, and a rise in serum prolactin (PRL) levels. However, the same treatments to males did not induce MCA despite a moderate increase in both pituitary weight and serum PRL. Ovariectomy prior to E2 treatment failed to modify the occurrence of MCA or pituitary tumors. When X-rays and E2 were given to female rats at 28-60 weeks of age, pituitary weight, serum PRL levels, and the incidence of MCA were unaffected. When the E2 pellet was kept for the first 24 weeks and withdrawn during the last 12 weeks, the incidence of MCA, pituitary weight, and serum PRL was low. It was concluded that: 1) the pituitary glands of young female rats were susceptible to E2 treatment but were insensitive in older females, and 2) the occurrence of MCA in female rats appeared to be promoted by elevated PRL levels secreted by E2-induced pituitary tumors. Mammary tissue of male rats was less sensitive to PRL levels in the development of MCA.

  15. Ovariectomized Sprague-Dawley and Long-Evans rats release prolactin differently in response to estrogen

    SciTech Connect (OSTI)

    Lawson, D.M.; Sensui, N.; Gala, R.R.

    1984-01-30T23:59:59.000Z

    Mature female Sprague-Dawley (SD) and Long-Evans (LE) rats were ovariectomized (OVX), and given a single sc injection of either 25 or 100 ..mu..g polyestradiol phosphate (PEP); seven days later blood samples were withdrawn at two hour intervals from 1100 to 2100 hours to detect the presence of an afternoon surge of prolactin (PRL). Other groups of OVX rats of both strains also treated with PEP were sampled before and at 2, 5, 10 and 30 min after iv administration of 1 ..mu..g synthetic thyrotropin releasing hormone (TRH). Pituitary (AP) and uterine weights were determined following sacrifice one day after TRH treatment. The AP homogenates and plasma samples were assayed for PRL by radioimmunoassay. Rats of both strains had afternoon PRL surges and in both strains the magnitude and/or duration of the surges were enhanced by the higher dose of PEP. However, within each PEP dose LE rats released significantly more PRL during the surge than did SD drats. Rats of both strains also rleased PRL in response to TRH and this response was enhanced in both strains by the higher of the two doses of PEP. These data not only show that strain differences exist in estrogen-induced or mediated PRL release in the rat but also indicate that the differences are not uniform.

  16. Final Report for DOE Grant DE-FG02-03ER25579; Development of High-Order Accurate Interface Tracking Algorithms and Improved Constitutive Models for Problems in Continuum Mechanics with Applications to Jetting

    SciTech Connect (OSTI)

    Puckett, Elbridge Gerry [U.C. Davis, Department of Mathematics; Miller, Gregory Hale [.C. Davis, Department of Chemical Engineering

    2012-10-14T23:59:59.000Z

    Much of the work conducted under the auspices of DE-FG02-03ER25579 was characterized by an exceptionally close collaboration with researchers at the Lawrence Berkeley National Laboratory (LBNL). For example, Andy Nonaka, one of Professor Miller's graduate students in the Department of Applied Science at U. C. Davis (UCD) wrote his PhD thesis in an area of interest to researchers in the Applied Numerical Algorithms Group (ANAG), which is a part of the National Energy Research Supercomputer Center (NERSC) at LBNL. Dr. Nonaka collaborated closely with these researchers and subsequently published the results of this collaboration jointly with them, one article in a peer reviewed journal article and one paper in the proceedings of a conference. Dr. Nonaka is now a research scientist in the Center for Computational Sciences and Engineering (CCSE), which is also part of the National Energy Research Supercomputer Center (NERSC) at LBNL. This collaboration with researchers at LBNL also included having one of Professor Puckett's graduate students in the Graduate Group in Applied Mathematics (GGAM) at UCD, Sarah Williams, spend the summer working with Dr. Ann Almgren, who is a staff scientist in CCSE. As a result of this visit Sarah decided work on a problem suggested by the head of CCSE, Dr. John Bell, for her PhD thesis. Having finished all of the coursework and examinations required for a PhD, Sarah stayed at LBNL to work on her thesis under the guidance of Dr. Bell. Sarah finished her PhD thesis in June of 2007. Writing a PhD thesis while working at one of the University of California (UC) managed DOE laboratories is long established tradition at UC and Professor Puckett has always encouraged his students to consider doing this. Another one of Professor Puckett's graduate students in the GGAM at UCD, Christopher Algieri, was partially supported with funds from DE-FG02-03ER25579 while he wrote his MS thesis in which he analyzed and extended work originally published by Dr. Phillip Colella, the head of ANAG, and some of his colleagues. Chris Algieri is now employed as a staff member in Dr. Bill Collins' Climate Science Department in the Earth Sciences Division at LBNL working with computational models of climate change. Finally, it should be noted that the work conducted by Professor Puckett and his students Sarah Williams and Chris Algieri and described in this final report for DOE grant # DE-FC02-03ER25579 is closely related to work performed by Professor Puckett and his students under the auspices of Professor Puckett's DOE SciDAC grant DE-FC02-01ER25473 An Algorithmic and Software Framework for Applied Partial Differential Equations: A DOE SciDAC Integrated Software Infrastructure Center (ISIC). Dr. Colella was the lead PI for this SciDAC grant, which was comprised of several research groups from DOE national laboratories and five university PI's from five different universities. In theory Professor Puckett tried to use funds from the SciDAC grant to support work directly involved in implementing algorithms developed by members of his research group at UCD as software that might be of use to Puckett's SciDAC CoPIs. (For example, see the work reported in Section 2.2.2 of this final report.) However, since there is considerable lead time spent developing such algorithms before they are ready to become `software' and research plans and goals change as the research progresses, Professor Puckett supported each member of his research group partially with funds from the SciDAC APDEC ISIC DE-FC02-01ER25473 and partially with funds from this DOE MICS grant DE-FC02-03ER25579. This has necessarily resulted in a significant overlap of project areas that were funded by both grants. In particular, both Sarah Williams and Chris Algieri were supported partially with funds from grant # DE-FG02-03ER25579, for which this is the final report, and in part with funds from Professor Puckett's DOE SciDAC grant # DE-FC02-01ER25473. For example, Sarah Williams received support from DE-FC02- 01ER25473 and DE-FC02-03ER25579, both while at UCD taking cla

  17. miller-er-99.PDF

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron4 Self-Scrubbing:,, , (Energy97 Upper TroposphericIVertical|Analysis

  18. Finite element analysis and computed tomography based structural rigidity analysis of rat tibia with simulated lytic defects

    E-Print Network [OSTI]

    Vaziri, Ashkan

    Finite element analysis and computed tomography based structural rigidity analysis of rat tibia) (Damron et al., 2003; Mirels, 1989). In contrast, Computed Tomography based Structural Rigidly Ana- lysis

  19. Final Technical Report "Catalytic Hydrogenation of Carbon Monoxide and Olefin Oxidation" Grant number : DE-FG02-86ER13615

    SciTech Connect (OSTI)

    Wayland, B.B.

    2009-08-31T23:59:59.000Z

    Title: Catalytic Hydrogenation of Carbon Monoxide and Olefin Oxidation Grant No. DE-FG02-86ER13615 PI: Wayland, B. B. (wayland@sas.upenn.edu) Abstract Development of new mechanistic strategies and catalyst materials for activation of CO, H2, CH4, C2H4, O2, and related substrates relevant to the conversion of carbon monoxide, alkanes, and alkenes to organic oxygenates are central objectives encompassed by this program. Design and synthesis of metal complexes that manifest reactivity patterns associated with potential pathways for the hydrogenation of carbon monoxide through metallo-formyl (M-CHO), dimetal ketone (M-C(O)-M), and dimetal dionyl (M-C(O)-C(O)-M) species is one major focus. Hydrocarbon oxidation using molecular oxygen is a central goal for methane activation and functionalization as well as regioselective oxidation of olefins. Discovery of new reactivity patterns and control of selectivity are pursued through designing new metal complexes and adjusting reaction conditions. Variation of reaction media promotes distinct reaction pathways that control both reaction rates and selectivities. Dimetalloradical diporphyrin complexes preorganize transition states for substrate reactions that involve two metal centers and manifest large rate increases over mono-metalloradical reactions of hydrogen, methane, and other small molecule substrates. Another broad goal and recurring theme of this program is to contribute to the thermodynamic database for a wide scope of organo-metal transformations in a range of reaction media. One of the most complete descriptions of equilibrium thermodynamics for organometallic reactions in water and methanol is emerging from the study of rhodium porphyrin substrate reactions in aqueous and alcoholic media. Water soluble group nine metalloporphyrins manifest remarkably versatile substrate reactivity in aqueous and alcoholic media which includes producing rhodium formyl (Rh-CHO) and hydroxy methyl (Rh-CH2OH) species. Exploratory directions for this program include expending new strategies for anti-Markovnikov addition of water, alcohols, and amines with olefins, developing catalytic reactions of CO to give formamides and formic esters, and evaluating the potential for coupling reactions of CO to produce organic building blocks.

  20. Ethanol seeking triggered by environmental context is attenuated by blocking dopamine D1 receptors in the nucleus accumbens core and shell in rats

    E-Print Network [OSTI]

    Chaudhri, Nadia; Sahuque, Lacey L.; Janak, Patricia H.

    2009-01-01T23:59:59.000Z

    self-administration when infused into either the NAc core ortest. As test rats were infused with saline and placed intotests where rats were infused with SCH 23390 (0, 0.006,

  1. Comparative Metabolism of Carbon Tetrachloride in Rats, Mice and Hamsters Using Gas Uptake and PBPK Modeling

    SciTech Connect (OSTI)

    Thrall, Karla D. (BATTELLE (PACIFIC NW LAB)); Vucelick, Mark E. (FLUOR HANFORD, INC); Gies, Richard A. (BATTELLE (PACIFIC NW LAB)); Zangar, Richard C. (BATTELLE (PACIFIC NW LAB)); Weitz, Karl K. (BATTELLE (PACIFIC NW LAB)); Poet, Torka S. (BATTELLE (PACIFIC NW LAB)); Springer, David L. (BATTELLE (PACIFIC NW LAB)); Grant, Donna M. (BATTELLE (PACIFIC NW LAB)); Benson, Janet M. (Inhalation Toxicology Research Institute)

    2000-08-25T23:59:59.000Z

    No study has comprehensively compared the rate of metabolism of carbon tetrachloride (CCl4) across species. Therefore, the in vivo metabolism of CCl4 was evaluated using groups of male animals (F344 rats, B6C3F1 mice, and Syrian hamsters) exposed to 40-1800 ppm CCl4 in a closed, recirculating gas-uptake system. For each species, an optimal fit of the family of uptake curves was obtained by adjusting Michaelis-Menten metabolic constants Km (affinity) and Vmax (capacity) using a physiologically based pharmacokinetic (PBPK) model. The results show that the mouse has a slightly higher capacity and lower affinity for metabolizing CCl4 compared to the rat, while the hamster has a higher capacity and lower affinity than either rat or mouse. A comparison of the Vmax to Km ratio, normalized for mg of liver protein (L/hr/mg) across species indicates that hamsters metabolize more CCl4 than either rats or mice, and should be more susceptible to CCl4-induced hepatotoxicity. These species comparisons were evaluated against toxicokinetic studies conducted in animals exposed by nose-only inhalation to 20 ppm 14C-labeled CCl4 for 4 hours. The toxicokinetic study results are consistent with the in vivo rates of metabolism, with rats eliminating less radioactivity associated with metabolism (14CO2 and urine/feces) and more radioactivity associated with the parent compound (radioactivity trapped on charcoal) compared to either hamsters or mice. The in vivo metabolic constants determined here, together with in vitro constants determined using rat, mouse, hamster and human liver microsomes, were used to estimate human in vivo metabolic rates of 1.49 mg/hr/kg body weight and 0.25 mg/L for Vmax and Km, respectively. Normalizing the rate of metabolism (Vmax/Km) by mg liver protein, the rate of metabolism of CCl4 differs across species, with hamster > mouse& > rat > human.

  2. Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats

    SciTech Connect (OSTI)

    Doerge, Daniel R., E-mail: daniel.doerge@fda.hhs.go [Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079 (United States); Twaddle, Nathan C.; Vanlandingham, Michelle [Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079 (United States); Fisher, Jeffrey W. [Department of Environmental Health Sciences, College of Public Health, University of Georgia, Athens, GA 30602 (United States)

    2010-09-01T23:59:59.000Z

    Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. The presence of BPA in urine of > 90% of Americans aged 6-60 suggests ubiquitous and frequent exposure. The current study used LC/MS/MS to measure serum pharmacokinetics of aglycone (active) and conjugated (inactive) BPA in adult and neonatal Sprague-Dawley rats by oral and injection routes. Deuterated BPA was used to avoid issues of background contamination. Linear pharmacokinetics were observed in adult rats treated orally in the range of 0-200 {mu}g/kg bw. Evidence for enterohepatic recirculation of conjugated, but not aglycone, BPA was observed in adult rats. Significant inverse relationships were observed between postnatal age and measures of internal exposures to aglycone BPA and its elimination. In neonatal rats treated orally, internal exposures to aglycone BPA were substantially lower than from subcutaneous injection. The results reinforce the critical role for first-pass Phase II metabolism of BPA in gut and liver after oral exposure that attenuates internal exposure to the aglycone form in rats of all ages. The internal exposures to aglycone BPA observed in adult and neonatal rats following a single oral dose of 100 {mu}g/kg bw are inconsistent with effects mediated by classical estrogen receptors based on binding affinities. However, an impact on alternative estrogen signaling pathways that have higher receptor affinity cannot be excluded in neonatal rats. These findings emphasize the importance of matching aglycone BPA internal dosimetry with receptor affinities in experimental animal studies reporting toxicity.

  3. Inhalation carcinogenicity study with nickel metal powder in Wistar rats

    SciTech Connect (OSTI)

    Oller, Adriana R. [NiPERA, 2605 Meridian Parkway, Suite 200, Durham, NC 27713 (United States)], E-mail: aoller@nipera.org; Kirkpatrick, Daniel T.; Radovsky, Ann [WIL Research Laboratories, LLC, 1407 George Road, Ashland, OH 44805 8946 (United States); Bates, Hudson K. [NiPERA, 2605 Meridian Parkway, Suite 200, Durham, NC 27713 (United States)

    2008-12-01T23:59:59.000Z

    Epidemiological studies of nickel refinery workers have demonstrated an association between increased respiratory cancer risk and exposure to certain nickel compounds (later confirmed in animal studies). However, the lack of an association found in epidemiological analyses for nickel metal remained unconfirmed for lack of robust animal inhalation studies. In the present study, Wistar rats were exposed by whole-body inhalation to 0, 0.1, 0.4, and 1.0 mg Ni/m{sup 3} nickel metal powder (MMAD = 1.8 {mu}m, GSD = 2.4 {mu}m) for 6 h/day, 5 days/week for up to 24 months. A subsequent six-month period without exposures preceded the final euthanasia. High mortality among rats exposed to 1.0 mg Ni/m{sup 3} nickel metal resulted in the earlier termination of exposures in this group. The exposure level of 0.4 mg Ni/m{sup 3} was established as the MTD for the study. Lung alterations associated with nickel metal exposure included alveolar proteinosis, alveolar histiocytosis, chronic inflammation, and bronchiolar-alveolar hyperplasia. No increased incidence of neoplasm of the respiratory tract was observed. Adrenal gland pheochromocytomas (benign and malignant) in males and combined cortical adenomas/carcinomas in females were induced in a dose-dependent manner by the nickel metal exposure. The incidence of pheochromocytomas was statistically increased in the 0.4 mg Ni/m{sup 3} male group. Pheochromocytomas appear to be secondary to the lung toxicity associated with the exposure rather than being related to a direct nickel effect on the adrenal glands. The incidence of cortical tumors among 0.4 mg Ni/m{sup 3} females, although statistically higher compared to the concurrent controls, falls within the historical control range; therefore, in the present study, this tumor is of uncertain relationship to nickel metal exposure. The lack of respiratory tumors in the present animal study is consistent with the findings of the epidemiological studies.

  4. In vitro dermal absorption of pyrethroid pesticides in human and rat skin

    SciTech Connect (OSTI)

    Hughes, Michael F., E-mail: hughes.michaelf@epa.go [Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Edwards, Brenda C. [Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States)

    2010-07-15T23:59:59.000Z

    Dermal exposure to pyrethroid pesticides can occur during manufacture and application. This study examined the in vitro dermal absorption of pyrethroids using rat and human skin. Dermatomed skin from adult male Long Evans rats or human cadavers was mounted in flow-through diffusion cells, and radiolabeled bifenthrin, deltamethrin or cis-permethrin was applied in acetone to the skin. Fractions of receptor fluid were collected every 4 h. At 24 h, the skins were washed with soap and water to remove unabsorbed chemical. The skin was then solubilized. Two additional experiments were performed after washing the skin; the first was tape-stripping the skin and the second was the collection of receptor fluid for an additional 24 h. Receptor fluid, skin washes, tape strips and skin were analyzed for radioactivity. For rat skin, the wash removed 53-71% of the dose and 26-43% remained in the skin. The cumulative percentage of the dose at 24 h in the receptor fluid ranged from 1 to 5%. For human skin, the wash removed 71-83% of the dose and 14-25% remained in the skin. The cumulative percentage of the dose at 24 h in the receptor fluid was 1-2%. Tape-stripping removed 50-56% and 79-95% of the dose in rat and human skin, respectively, after the wash. From 24-48 h, 1-3% and about 1% of the dose diffused into the receptor fluid of rat and human skin, respectively. The pyrethroids bifenthrin, deltamethrin and cis-permethrin penetrated rat and human skin following dermal application in vitro. However, a skin wash removed 50% or more of the dose from rat and human skin. Rat skin was more permeable to the pyrethroids than human skin. Of the dose in skin, 50% or more was removed by tape-stripping, suggesting that permeation of pyrethroids into viable tissue could be impeded. The percentage of the dose absorbed into the receptor fluid was considerably less than the dose in rat and human skin. Therefore, consideration of the skin type used and fractions analyzed are important when using in vitro dermal absorption data for risk assessment.

  5. Dietary apigenin and naringenin protect against colon carcinogenesis by lowering high multiplicity aberrant crypt foci and enhancing apoptosis in azoxymethane-treated rats

    E-Print Network [OSTI]

    Leonardi, Tety

    2006-08-16T23:59:59.000Z

    investigated the potentially protective effects of four citrus flavonoids and one limonoid mixture against the promotion stage of chemically-induced colon cancer in rats. Male SD rats (n =60; 10 rats/group) were assigned to receive diets containing 0...

  6. Physiologically based Pharmacokinetic Modeling of 1,4-Dioxane in Rats, Mice, and Humans

    SciTech Connect (OSTI)

    Sweeney, Lisa M.; Thrall, Karla D.; Poet, Torka S.; Corley, Rick; Weber, Thomas J.; Locey, B. J.; Clarkson, Jacquelyn; Sager, S.; Gargas, M. L.

    2008-01-01T23:59:59.000Z

    ABSTRACT 1,4-Dioxane (CAS No. 123-91-1) is used primarily as a solvent or as a solvent stabilizer. It can cause lung, liver and kidney damage at sufficiently high exposure levels. Two physiologically-based pharmacokinetic (PBPK) models of 1,4-dioxane and its major metabolite, hydroxyethoxyacetic acid (HEAA), were published in 1990. These models have uncertainties and deficiencies that could be addressed and the model strengthened for use in a contemporary cancer risk assessment for 1,4-dioxane. Studies were performed to fill data gaps and reduce uncertainties pertaining to the pharmacokinetics of 1,4-dioxane and HEAA in rats, mice, and humans. Three types of studies were performed:partition coefficient measurements, blood time course in mice, and in vitro pharmacokinetics using rat, mouse, and human hepatocytes. Updated PBPK models were developed based on these new data and previously available data. The optimized rate of metabolism for the mouse was significantly higher than the value previously estimated. The optimized rat kinetic parameters were similar to those in the 1990 models. Only two human studies were identified. Model predictions were consistent with one study, but did not fit the second as well. In addition, a rat nasal exposure was completed. The results confirmed water directly contacts rat nasal tissues during drinking water under bioassays. Consistent with previous PBPK models, nasal tissues were not specifically included in the model. Use of these models will reduce the uncertainty in future 1,4-dioxane risk assessments.

  7. Pancreatic hydrolases in cold-induced hyperphagia of rats fed a low or high-fat diet

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    -Bellevue, France. Summary. Rats fed either a low (2 p. 100) or high (40 p. 100)-fat diet were exposed to 22 or 5 °C consumption which entails increased digestive processes. The cold-adapted rat therefore provides containing 2.5 p. 100 lard supplemented with 0.4 p. 100 sunflower oil to provide the necessary unsaturated

  8. Methods for testing the strength of cancellous bone and tested method effects on cortical bone in the ovariectomized rat 

    E-Print Network [OSTI]

    Ruhmann, Sean Phillip

    1998-01-01T23:59:59.000Z

    In this study, two mechanical testing procedures were developed to test the strength of cancellous bone from the proximal tibia of the rat, the "punch method" and the "whole slice method". These were used to quantify the effect of ovariectomy on rat...

  9. A Novel Method for the Evaluation of Mechanical Properties of Cancellous Bone in the Rat Distal Femur 

    E-Print Network [OSTI]

    Lucas, Matthew W.

    2010-01-14T23:59:59.000Z

    .................................................................................................................. 35 3.7.1 Analysis of Mechanical Testing Data .............................................................. 35 3.7.2 Material Properties ........................................................................................... 37 3.7.3 Core....2 Osteoporosis and the Ovariectomized Rat Model .................................................... 5 2.3 Mechanical Testing of Cancellous Bone in Rats ..................................................... 5 2.3.1 Femoral Neck Testing...

  10. Characterization of the Bone Loss and Recovery Response at the Distal Femur Metaphysis of the Adult Male Hindlimb Unloaded Rat 

    E-Print Network [OSTI]

    Davis, Joshua Morgan

    2012-02-14T23:59:59.000Z

    Metaphysis of the Rat ....................................................................... 10 2.4 Mechanical Testing Methods for Rat Distal Femur Metaphysis ............................ 13 2.5 Reduced Platen Compression Mechanical Testing... ........................................................... 27 3.5 RPC Mechanical Testing and Analysis .................................................................... 30 3.6 Data Analysis .......................................................................................................... 32 4...

  11. Failure to find aversive marking of toxic foods by Norway rats BENNETT G. GALEF, JR, SHANNON PRETTY & ELAINE E. WHISKIN

    E-Print Network [OSTI]

    Galef Jr., Bennett G.

    Failure to find aversive marking of toxic foods by Norway rats BENNETT G. GALEF, JR, SHANNON PRETTY, not where or what they avoid eating. We discuss possible ultimate explanations for this failure of naive a rat dam is eating may enter her amni- otic fluid, and fetal exposure to such cues may enhance pups

  12. Methods for testing the strength of cancellous bone and tested method effects on cortical bone in the ovariectomized rat

    E-Print Network [OSTI]

    Ruhmann, Sean Phillip

    1998-01-01T23:59:59.000Z

    of the effect of two testing methods, torsion and three-point bending, on the mechanical strength of the rat femur and the changes in strength due to ovariectomy. From these tests, little change in cortical bone properties for the OVX rats compared to the Sham...

  13. The effects of exercise and dietary fat on calcium, magnesium, iron, and zinc on selected tissues in rats

    E-Print Network [OSTI]

    Nguyen, Thuy Huong

    1989-01-01T23:59:59.000Z

    and had a 12-hour photoperiod. Cages were lined with woodchip bedding, and stainless steel feeders were used. Design Following a three-day acclimation period, during which rats were fed the control diet, the rats were weighed and randomly assigned...

  14. Oxytocin receptors in the nucleus accumbens shell are involved in the consolidation of maternal memory in postpartum rats

    E-Print Network [OSTI]

    Sokolowski, Marla

    memory. In Experiment 1, postpartum female rats given 1 hour of maternal experience were infused, postpartum female rats were infused with either a high or low dose of OT into the NA shell after a 15-minute no significant differences between the females infused with OT and females treated with a vehicle infused

  15. Neutral sphingomyelinase inhibition participates to the benefits of N-acetylcysteine treatment in post-myocardial infarction failing heart rats

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    treatment in post- myocardial infarction failing heart rats Christophe ADAMY1,2,9 , Paul MULDER3,4,9 , Lara-MI failing heart rat Key words: chronic heart failure; glutathione; N-acetylcysteine; neutral, we showed that the left ventricle (LV) of human failing heart was depleted in total glutathione by 54

  16. Dual constrictor and dilator actions of ETB receptors in the rat renal microcirculation: interactions with ETA receptors

    E-Print Network [OSTI]

    Just, Armin

    Dual constrictor and dilator actions of ETB receptors in the rat renal microcirculation, and William J. Arendshorst. Dual constrictor and dilator actions of ETB receptors in the rat renal the combination of vasoconstrictor ETA and ETB receptors on smooth muscle cells and vasodilator ETB receptors

  17. The effect of alcohol on the bone growth spurt of rats at a time equivalent to adolescent females 

    E-Print Network [OSTI]

    Chaffin, Catherine Lee

    1997-01-01T23:59:59.000Z

    The objective of this study is to determine the effect of long-term alcohol consumption on the growth spurt in adolescent rats. Female Sprague-Dawley rats were fed one of three diets (alcohol, pair-fed or chow) for 3 months. ...

  18. Extracellular calcium sensing in rat aortic vascular smooth muscle cells

    SciTech Connect (OSTI)

    Smajilovic, Sanela [Laboratory of Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet (Denmark); Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen (Denmark); Hansen, Jakob Lerche [Laboratory of Molecular and Cellular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet (Denmark); Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen (Denmark); Christoffersen, Tue E.H. [Laboratory of Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet (Denmark); Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), Copenhagen (Denmark)] (and others)

    2006-10-06T23:59:59.000Z

    Extracellular calcium (Ca2+o) can act as a first messenger in many cell types through a G protein-coupled receptor, calcium-sensing receptor (CaR). It is still debated whether the CaR is expressed in vascular smooth muscle cells (VSMCs). Here, we report the expression of CaR mRNA and protein in rat aortic VSMCs and show that Ca2+o stimulates proliferation of the cells. The effects of Ca2+o were attenuated by pre-treatment with MAPK kinase 1 (MEK1) inhibitor, as well as an allosteric modulator, NPS 2390. Furthermore, stimulation of the VSMCs with Ca2+o-induced phosphorylation of ERK1/2, but surprisingly did not cause inositol phosphate accumulation. We were not able to conclusively state that the CaR mediates Ca2+o-induced cell proliferation. Rather, an additional calcium-sensing mechanism may exist. Our findings may be of importance with regard to atherosclerosis, an inflammatory disease characterized by abnormal proliferation of VSMCs and high local levels of calcium.

  19. Luminescence properties of light-emitting diodes based on GaAs with the up-conversion Y{sub 2}O{sub 2}S:Er,Yb luminophor

    SciTech Connect (OSTI)

    Gruzintsev, A. N. [Russian Academy of Sciences, Institute of Problems of Microelectronics Technology (Russian Federation)], E-mail: gran@ipmt-hpm.ac.ru; Barthou, C.; Benalloul, P. [Institute des NanoSciences (France)

    2008-03-15T23:59:59.000Z

    Y{sub 2}O{sub 2}S luminophors doped with Er{sup 3+} and Yb{sup 3+} ions are produced by means of solid-phase synthesis and deposited onto standard AL123A infrared light-emitting diodes. When excited with 940 nm radiation from a light-emitting diode, the structures exhibit intense visible up-conversion luminescence. A maximal brightness of 2340 cd/m{sup 2} of green and red up-conversion luminescence at corresponding wavelengths around 550 and 600 nm is observed for the Y{sub 2}O{sub 2}S compound doped with 2 at % Er{sup 3+} ions and 6 at % Yb{sup 3+} ions. The ratio of the intensity of green (or red) up-conversion luminescence to the intensity of infrared Stokes luminescence increases with increasing applied voltage. The efficiency of visible emission of the light-emitting diode structures is {eta} = 1.2 lm/W at an applied voltage of 1.5 V.

  20. Cardiovascular changes in unanesthetized and ketamine-anesthetized Sprague-Dawley rats exposed to 2. 8-GHz radiofrequency radiation

    SciTech Connect (OSTI)

    Jauchem, J.R.; Frei, M.R. (United States Air Force School of Aerospace Medicine, Brooks Air Force Base, TX (USA))

    1991-01-01T23:59:59.000Z

    Sprague-Dawley rats were exposed to 2.8-GHz radiofrequency radiation, first while unanesthetized and then while anesthetized with ketamine (150 mg/kg.I.M.). Irradiation at a power density of 60 mW/cm2 (whole-body average specific absorption rate of approximately 14 W/kg) was conducted for sufficient duration to increase colonic temperature from 38.5 to 39.5 degrees C. The time required for the temperature increase was significantly longer in the anesthetized state. During irradiation, heart rate increased significantly both with and without anesthesia, while mean arterial blood pressure increased only when the rats were unanesthetized. The heart rate increase in the anesthetized state contrasts with a lack of change in a previous study of Fischer rats. This difference between anesthetized Sprague-Dawley and Fischer rats should be considered when comparing cardiovascular data obtained from these two strains of rats.

  1. Genome sequence of the brown Norway rat yields insights into mammalian evolution

    SciTech Connect (OSTI)

    Gibbs, Richard A.; Weinstock, George M.; Metzker, Michael L.; Muzny, Donna M.; Sodergren, Erica J.; Scherer, Steven; Scott, Graham; Steffen, David; Worley, Kim C.; Burch, Paula E.; Okwuonu, Geoffrey; Hines, Sandra; Lewis, Lora; DeRamo, Christine; Delgado, Oliver; Dugan-Rocha, Shannon; Miner, George; Morgan, Margaret; Hawes, Alicia; Gill, Rachel; Holt, Robert A.; Adams, Mark D.; Amanatides, Peter G.; Baden-Tillson, Holly; Barnstead, Mary; Chin, Soo; Evans, Cheryl A.; Ferriera, Steven; Fosler, Carl; Glodek, Anna; Gu, Zhiping; Jennings, Don; Kraft, Cheryl L.; Nguyen, Trixie; Pfannkoch, Cynthia M.; Sitter, Cynthia; Sutton, Granger G.; Venter, J. Craig; Woodage, Trevor; Smith, Douglas; Lee, Hong-Maei; Gustafson, Erik; Cahill, Patrick; Kana, Arnold; Doucette-Stamm, Lynn; Weinstock, Keith; Fechtel, Kim; Weiss, Robert B.; Dunn, Diane M.; Green, Eric D.; Blakesley, Robert W.; Bouffard, Gerard G.; de Jong, Pieter J.; Osoegawa, Kazutoyo; Zhu, Baoli; Marra, Marco; Schein, Jacqueline; Bosdet, Ian; Fjell, Chris; Jones, Steven; Krzywinski, Martin; Mathewson, Carrie; Siddiqui, Asim; Wye, Natasja; McPherson, John; Zhao, Shaying; Fraser, Claire M.; Shetty, Jyoti; Shatsman, Sofiya; Geer, Keita; Chen, Yixin; Abramzon, Sofyia; Nierman, William C.; Havlak, Paul H.; Chen, Rui; Durbin, K. James; Egan, Amy; Ren, Yanru; Song, Xing-Zhi; Li, Bingshan; Liu, Yue; Qin, Xiang; Cawley, Simon; Cooney, A.J.; D'Souza, Lisa M.; Martin, Kirt; Wu, Jia Qian; Gonzalez-Garay, Manuel L.; Jackson, Andrew R.; Kalafus, Kenneth J.; McLeod, Michael P.; Milosavljevic, Aleksandar; Virk, Davinder; Volkov, Andrei; Wheeler, David A.; Zhang, Zhengdong; Bailey, Jeffrey A.; Eichler, Evan E.; Tuzun, Eray; Birney, Ewan; Mongin, Emmanuel; Ureta-Vidal, Abel; Woodwark, Cara; Zdobnov, Evgeny; Bork, Peer; Suyama, Mikita; Torrents, David; Alexandersson, Marina; Trask, Barbara J.; Young, Janet M.; et al.

    2004-02-02T23:59:59.000Z

    The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90 percent of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution.

  2. Application of synchrotron radiation computed microtomography for quantification of bone microstructure in human and rat bones

    SciTech Connect (OSTI)

    Parreiras Nogueira, Liebert; Barroso, Regina Cely; Pereira de Almeida, Andre; Braz, Delson; Almeida, Carlos Eduardo de; Borba de Andrade, Cherley; Tromba, Giuliana [Nuclear Instrumentation Laboratory / COPPE / UFRJ, P.O. Box 68509, 21945-970, Rio de Janeiro (Brazil); Physics Institute / State University of Rio de Janeiro, 20550-900, Rio de Janeiro (Brazil); Nuclear Instrumentation Laboratory / COPPE / UFRJ, P.O. Box 68509, 21945-970, Rio de Janeiro (Brazil); Laboratory of Radiological Sciences / State University of Rio de Janeiro, Rio de Janeiro (Brazil); Sincrotrone Trieste SCpA, Strada Statale S.S. 14 km 163.5, 34012 Basovizza, Trieste (Italy)

    2012-05-17T23:59:59.000Z

    This work aims to evaluate histomorphometric quantification by synchrotron radiation computed microto-mography in bones of human and rat specimens. Bones specimens are classified as normal and pathological (for human samples) and irradiated and non-irradiated samples (for rat ones). Human bones are specimens which were affected by some injury, or not. Rat bones are specimens which were irradiated, simulating radiotherapy procedures, or not. Images were obtained on SYRMEP beamline at the Elettra Synchrotron Laboratory in Trieste, Italy. The system generated 14 {mu}m tomographic images. The quantification of bone structures were performed directly by the 3D rendered images using a home-made software. Resolution yielded was excellent what facilitate quantification of bone microstructures.

  3. Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease

    SciTech Connect (OSTI)

    Wolff, J.A.; Fisher, L.J.; Xu, L.; Jinnah, H.A.; Rosenberg, M.B.; Shimohama, S.; Gage, F.H. (Univ. of California School of Medicine, La Jolla (USA)); Langlais, P.J. (Univ. of California School of Medicine, La Jolla (USA) School of Medicine and Veterans Administration Medical Center, La Jolla (USA) San Diego State Univ., CA (USA)); Iuvone, P.M. (Emory Univ., Atlanta, GA (USA)); O'Malley, K.L. (Washington Univ. School of Medicine, St. Louis, MO (USA))

    1989-11-01T23:59:59.000Z

    Rat fibroblasts were infected with a retroviral vector containing the cDNA for rat tyrosine hydroxylase. A TH-positive clone was identified by biochemical assay and immunohistochemical staining. When supplemented in vitro with pterin cofactors required for TH activity, these cells produced L-dopa and released it into the cell cultured medium. Uninfected control cells and fibroblasts infected with the TH vector were grafted separately to the caudate of rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. Only grafts containing TH-expressing fibroblasts were found to reduce rotational asymmetry. These results have general implications for the application of gene therapy to human neurological disease and specific implications for Parkinson disease.

  4. The urinary excretion of unchanged d-amphetamine by rats at ground level and at altitude

    E-Print Network [OSTI]

    Harwell, James Franklin

    1968-01-01T23:59:59.000Z

    divided into 3 equal groups. One group received ammonium chloride to acidify the urine, a second group received sodium bicarbonate to alkalinize the urine, and the third group received distilled water. Immediately after receiving the pretreatment... solutions each rat was in3ected subcutaneously with d-amphetamine sulfate at the rate of 3 mg/kg body weight. Each rat was put into a metabolic cage and a 4 hour urine sample was collected at ground level. After a rest period of at least 48 hours...

  5. Chronic cellular responses of rat skin to 13 Mev proton irradiation

    E-Print Network [OSTI]

    Hinkle, Donald King

    1966-01-01T23:59:59.000Z

    CHRONIC CELLULAR RESPONSES OF RAT SKIN TO 13 MEV PROTON IRRADIATION A Thesis by DONALD KING HINKLE, D. V. M. Submitted to the Graduate College of the Texas AErM University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE August 1966 Major Subject: Laboratory Animal Medicine CHRONIC CELLULAR RESPONSES OF RAT SKIN TO 13 MEV PROTON IRRADIATION A Thesis by DONALD KING HINKLE, D. V. M. Submitted to the Graduate College of the Texas ARM University in partial...

  6. Effect of exercise training and dietary fat on rat adipose tissue lipolysis and morphology

    E-Print Network [OSTI]

    Neale, Sonia Barstad

    1989-01-01T23:59:59.000Z

    . , Colorado State University Co-Chairs of Advisory Committee: Dr. Karen S. Kubena Dr. Stephen B. Smith The effects of exercise training and dietary fat on lipolysis rate and adipocyte morphology of epididymal fat pads were studied. Male rats (5 wk old...-free. The diets were initiated when the rats were 4 wk old. Body weight (p&0. 001), fat pad weight (p&0. 001), and adipocyte diameter (p&0. 05) were significantly less in the exercised group than in the sedentary group. Adipocyte number was not significantly...

  7. Toxicity of polychlorinated diphenyl ethers in Hydra attenuata and in rat whole embryo culture

    E-Print Network [OSTI]

    Becker, Marion Carol

    1991-01-01T23:59:59.000Z

    TOXICITY OF POLYCHLORINATED DIPHENYL ETHERS IN HYDRA A?TENUATA AND IN RAT WHOLE EMBRYO CULTURE A Thesis by MARION CAROL BECKER Submitted to the Office of Graduate Studies of Texas A8cM University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE May 1991 Major Subject: Toxicology TOXICITY OF POLYCHLORINATED DIPHENYL ETHERS IN HYDRA A1TENUATA AND IN RAT WHOLE EMBRYO CULTURE by MARION CAROL BECKER Approved as to style and content by: Stephen H. S (Ca...

  8. Toxicity of polychlorinated diphenyl ethers in Hydra attenuata and in rat whole embryo culture 

    E-Print Network [OSTI]

    Becker, Marion Carol

    1991-01-01T23:59:59.000Z

    TOXICITY OF POLYCHLORINATED DIPHENYL ETHERS IN HYDRA A?TENUATA AND IN RAT WHOLE EMBRYO CULTURE A Thesis by MARION CAROL BECKER Submitted to the Office of Graduate Studies of Texas A8cM University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE May 1991 Major Subject: Toxicology TOXICITY OF POLYCHLORINATED DIPHENYL ETHERS IN HYDRA A1TENUATA AND IN RAT WHOLE EMBRYO CULTURE by MARION CAROL BECKER Approved as to style and content by: Stephen H. S (Ca...

  9. Testicular damage and regeneration in rats following low-level gamma irradiation

    E-Print Network [OSTI]

    Maxwell, Wesley Howard

    1974-01-01T23:59:59.000Z

    of these animals were examined using several recognized histological procedures. The sequential damage and recovezy of the germinal epithelium was s'tudied for S4 days post-irradiation. The lower dose rate (7 R/hr) resulted in temporari. ly arresting meiotic...- ation of the germinal epithelium of rats irradiated with 7 R/hr was seen by 84 days post-irradiation. However, this same time iv. was not sufficient for total recovery of the rats irradiated to a total dose of 1000 R, at 14 R/hr. ACKNOWLEDGEMENT...

  10. Magnesium and pyridoxine intake and mineral content of selected tissues and physical development in rats 

    E-Print Network [OSTI]

    Edgar, Susan Elaine

    1986-01-01T23:59:59.000Z

    lower f eed intake s than did rats from other dietary treatments. During lactation, dai ly feed consumpt ion was lower in an ima1 s depr ived of magnesium. Approximately 24 hr postpartum, in dams who consumed a magnesium-deficient diet, the heart... and kidney contained significantly more calcium, 150'% and 300% respectively. During lactation, mild magnesium restriction resulted in increased weight loss by dams and decreased weight gain by pupa. In the of f spring of rats dep1 et ed o f magnesium...

  11. S I M O N F RASE R U N I V ERS I T Y E N V I R O N M E N T A L H E A L T H & S A F E T Y

    E-Print Network [OSTI]

    S I M O N F RASE R U N I V ERS I T Y E N V I R O N M E N T A L H E A L T H & S A F E T Y Rodent the Plan. The plan was last updated on April 22, 2009. #12;S I M O N F RASE R U N I V ERS I T Y E N V I R O N M E N T A L H E A L T H & S A F E T Y EHS April 22, 2009 3/10 Table of Contents 1 INTRODUCTION

  12. 5-Hydroxy-L-tryptophan suppresses food intake in food-deprived and stressed rats

    E-Print Network [OSTI]

    Wurtman, Richard

    Research Center, Massachusetts Institute of Technology, Cambridge, MA, USA c Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA Received 22 January 2003 deprivation and a standardized stress (tail pinch), and on plasma 5-HTP levels in humans. In rats, 5-HTP (3

  13. High-resolution imaging of vessels in the isolated rat brain M. F. Valverde Salzmann1

    E-Print Network [OSTI]

    for the distribution of vessels in the rat brain. Angiography is able to use the blood flow in the brain of the living into a test tube filled with fluorocarbon fluid for susceptibility matching. MR Images were acquired at a horizontal 16.4 T scanner with a homemade microstrip volume coil, using gradient echo sequences

  14. Resveratrol Improves Survival, Hemodynamics and Energetics in a Rat Model of Hypertension Leading to

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Resveratrol Improves Survival, Hemodynamics and Energetics in a Rat Model of Hypertension Leading and vascular function as well as cardiac and skeletal muscle energy metabolism were assessed in a hypertensive/kg/day; HS-RSV) was given for 8 weeks after hypertension and cardiac hypertrophy were established (which

  15. Polycyclic Aromatic Hydrocarbons Present in Cigarette Smoke Cause Bone Loss in an Ovariectomized Rat Model

    E-Print Network [OSTI]

    Waldman, Stephen D.

    of epidemiological studies have suggested that cigarette smoking is a risk factor for osteoporosis. Benzo- (a and fragility seen in smoking-related osteoporosis. In this study four groups of 9-month-old Sprague-Dawley rats; Ovariectomy (ovx); Estrogen; Osteoporosis. Introduction Epidemiological studies have focused

  16. Some histological manifestations in the vitamin B b12 sdeficient newborn rat

    E-Print Network [OSTI]

    Jones, Carroll Christian

    1954-01-01T23:59:59.000Z

    &dna;, . and spieen 1n duced by a materw?l v1tamin Rl? deficiency 1? the ?suborn albino rat, 4 secondary porno a Ips to co"lpga e the '?Jot'. , +t dif faro loca bot'i&en the hearts, livorn and '. . Tdnevs of novborn offspring oi' v'to oin Q2 deficient mothers...

  17. Imaging Oxygen Consumption in Forepaw Somatosensory Stimulation in Rats Under Isoflurane Anesthesia

    E-Print Network [OSTI]

    Duong, Timothy Q.

    Imaging Oxygen Consumption in Forepaw Somatosensory Stimulation in Rats Under Isoflurane Anesthesia consumption, indicative of partial coupling of CBF and CMRO2. This study describes a useful forepaw. Following Fox et al.'s (2) initial study with positron emission tomography (PET), stimulus- evoked CMRO2

  18. Diffuse Optical Tomography of Cerebral Blood Flow, Oxygenation, and Metabolism in Rat During Focal Ischemia

    E-Print Network [OSTI]

    Yodh, Arjun G.

    of oxygen consumption (CMRO2). Temporary (60-minute) MCAO was performed on five rats. Ischemic changes--Cerebral metabolic rate of oxygen consumption. Diffuse optical tomography (DOT) of the brain is an attractive new complementary to those of magnetic resonance imaging (MRI) and positron emission tomog- raphy (PET), and holds

  19. anticoagulant-susceptible norway rats: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    anticoagulant-susceptible norway rats First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Assessing the...

  20. Effects of Dietary Lead and Cholesterol Supplementation on Hemolysis in the Sprague-Dawley Rat1

    E-Print Network [OSTI]

    Moore, Paul A.

    Effects of Dietary Lead and Cholesterol Supplementation on Hemolysis in the Sprague-Dawley Rat1 has been observed in a number of organisms exposed to lead. Previous investigators have proposed into the serum. Lead-exposed fish have displayed depressed serum cholesterol and elevated serum protein

  1. Inhalation developmental toxicology studies: Teratology study of acetone in mice and rats: Final report

    SciTech Connect (OSTI)

    Mast, T.J.; Evanoff, J.J.; Rommereim, R.L.; Stoney, K.H.; Weigel, R.J.; Westerberg, R.B.

    1988-11-01T23:59:59.000Z

    Acetone, an aliphatic ketone, is a ubiquitous industrial solvent and chemical intermediate; consequently, the opportunity for human exposure is high. The potential for acetone to cause developmental toxicity was assessed in Sprague-Dawley rats exposed to 0, 440, 2200, or 11000 ppm, and in Swiss (CD-1) mice exposed to 0, 440, 2200, and 6600 ppm acetone vapors, 6 h/day, 7 days/week. Each of the four treatment groups consisted of 10 virgin females (for comparison), and approx.32 positively mated rats or mice. Positively mated mice were exposed on days 6-17 of gestation (dg), and rats on 6-19 dg. The day of plug or sperm detection was designated as 0 dg. Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice (rats, 20 dg; mice, 18 dg). Implants were enumerated and their status recorded. Live fetuses were sexed and examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. 46 refs., 6 figs., 27 tabs.

  2. JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR INCREASED EATING IN RATS DEPRIVED OF RUNNING'

    E-Print Network [OSTI]

    Premack, David

    JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR INCREASED EATING IN RATS DEPRIVED OF RUNNING of the wheel. When this outcome is coupled with the positive relation between food deprivation and running-and food depriva- tion is seen as a loss of eating rather than as a physiological state

  3. Dim Light at Night Increases Immune Function in Nile Grass Rats, a Diurnal Rodent

    E-Print Network [OSTI]

    Nelson, Randy J.

    Dim Light at Night Increases Immune Function in Nile Grass Rats, a Diurnal Rodent Laura K. Fonken lighting during the 20th century, human and nonhuman animals became exposed to high levels of light significant implications for certain ecological niches because of the important influence light exerts

  4. Effect of fermentable carbohydrates on volatile fatty acids, ammonia and mineral absorption in the rat caecum

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    intestine on caecal digestion and absorption have been studied in the rat. Even in diets lacking these carbo of the urea nitrogen was used in bacterial protein synthesis. Arteriovenous differences in the caecum showed, for which hydrolysing enzymes are lacking or poorly efficient in the small i ntesti ne. These carbohydrates

  5. A Glucose BioFuel Cell Implanted in Rats Philippe Cinquin1

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    A Glucose BioFuel Cell Implanted in Rats Philippe Cinquin1 *, Chantal Gondran2 , Fabien Giroud2 powerful ones, Glucose BioFuel Cells (GBFCs), are based on enzymes electrically wired by redox mediators applications. Citation: Cinquin P, Gondran C, Giroud F, Mazabrard S, Pellissier A, et al. (2010) A Glucose BioFuel

  6. Inositol lipid metabolism in vasopressin stimulated hepatocytes from rats infused with tumor necrosis factor

    SciTech Connect (OSTI)

    Spitzer, J.A.; Rodriguez de Turco, E.B. (Louisiana State Univ. Medical Center, New Orleans (USA))

    1989-05-30T23:59:59.000Z

    We studied the effect of i.v. infusion of human recombinant tumor necrosis factor alpha (rHuTNF alpha, Cetus, 15 micrograms/100 g bw over 3 h) on vasopressin (VP)-stimulated {sup 32}P-inositol lipid turnover and the release of {sup 3}H-inositol phosphates in isolated rat hepatocytes. The early VP-induced decrease (within 30 s) in {sup 32}P-phosphatidylinositol 4-phosphate and {sup 32}P-phosphatidylinositol 4,5-bisphosphate labeling was significantly reduced (-40%) and at the same time the uptake of {sup 32}P into phosphatidic acid was 50% lower than in saline-infused (matched control) rats. Within 5 min of VP-stimulation, lower {sup 32}P phosphatidylinositol (-40%) and higher {sup 32}P-phosphatidic acid (+30%) labeling were observed in rHuTNF alpha-infused rats. Infusion of rHuTNF alpha also affected the VP-induced release of {sup 3}H-inositol phosphates. The accumulation of {sup 3}H-inositol-labeled water soluble products was decreased by 25% and 17% at 30 s and 10 min, respectively. These data show that rHuTNF alpha mimics early perturbations induced by Escherichia coli endotoxin infusion in VP-stimulated inositol lipid metabolism in rat hepatocytes.

  7. acid-challenged rat stomach: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    acid-challenged rat stomach First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Activities of amino acid...

  8. ALZHEIMER'S AMYLOID-BETA PEPTIDE INHIBITS SODIUM/CALCIUM EXCHANGE MEASURED IN RAT AND

    E-Print Network [OSTI]

    ALZHEIMER'S AMYLOID-BETA PEPTIDE INHIBITS SODIUM/CALCIUM EXCHANGE MEASURED IN RAT AND HUMAN BRAIN-beta1­40 (A 1­40) and A 25­35 reduced vesicular Ca2+ content. Both peptides produced a maximal reduction in Ca2+ content of approximately 50%. The peptides reduced Ca2+ content with similar potency and half

  9. UPTAKE OF [3H]-COLCHICINE INTO BRAIN AND LIVER OF MOUSE, RAT, AND CHICK

    E-Print Network [OSTI]

    Bennett, Edward L.

    2010-01-01T23:59:59.000Z

    by M.R. Rosenzweig and E.l. Bennett, Cambridge, MA: The MITJ.F. , D.W. landry, E.l. Bennett, and M.E. Jarvik. long-termRAT,AND CHICK Edward L. Bennett, Marie Hebert Alberti, and

  10. Imaging of Alcohol-Induced Dopamine Release in Rats: Preliminary Findings With

    E-Print Network [OSTI]

    Morris, Evan D,

    . Normandin: Yale PET Center, P.O. Box 208048, New Haven, CT 06520 *Correspondence to: Evan D. Morris, YaleImaging of Alcohol-Induced Dopamine Release in Rats: Preliminary Findings With [11 C]Raclopride PET positron emission tomography (PET). PET images were acquired in 44 alcohol-nai¨ve male Wistar and alcohol

  11. fMRI visualisation of transient activations in the rat olfactory bulb using short odour stimulations

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    fMRI visualisation of transient activations in the rat olfactory bulb using short odour in the olfactory bulb OB displays both spatial and temporal organization. The difficulty when assessing spatio of the olfactory bulb (OB). Hence, in this structure, the identity of odorants is associated with a unique spatial

  12. Increased severity of acute Trypanosoma brucei brucei infection in rats with alloxan-induced diabetes

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    -induced diabetes Ikechukwu Onyebuchi Igbokwea Sani Isaa Umma Kalsum Aliyub Hajja Gana Hamzab Tobias Egbe made diabetic by treatment with alloxan monohydrate (10 % solution, 100 mg/kg body weight). Ten diabetic and ten non-diabetic rats were intraperitoneally infected with the same infective doses

  13. Grid Cells and Theta as Oscillatory Interference: Electrophysiological Data From Freely Moving Rats

    E-Print Network [OSTI]

    Burgess, Neil

    Grid Cells and Theta as Oscillatory Interference: Electrophysiological Data From Freely Moving Rats, regular firing patterns by medial entorhinal cortical (mEC) grid cells in terms of the interference specific relationships between the intrinsic firing frequency and spa- tial scale of grid cell firing

  14. Regulation of Endothelial Phenotype in Rat Soleus Muscle Feed Arteries: Influence of Aging and Exercise Training 

    E-Print Network [OSTI]

    Trott, Daniel Wayne

    2012-02-14T23:59:59.000Z

    (AUC) was calculated using the trapezoidal method. Body composition and adiposity. The body mass of the rats was measured to the nearest 0.01 g and body composition was determined using dual-energy x-ray absorptiometry (Hologic QDR-1000/w DEXA...

  15. How Enrichment Affects Exploration Trade-Offs in Rats: Implications for Welfare and Well-Being

    E-Print Network [OSTI]

    Champagne, Frances A.

    How Enrichment Affects Exploration Trade-Offs in Rats: Implications for Welfare and Well-being and animal welfare, we designed a novel test of exploration behavior. Environmentally and socially enriched, 20 animals remained in enriched housing (enrichment-maintenance) while 40 animals were re

  16. Plasma kinetics, tissue distribution, and cerebrocortical sources of reverse triiodothyronine in the rat

    SciTech Connect (OSTI)

    Obregon, M.J.; Larsen, P.R.; Silva, J.E.

    1985-06-01T23:59:59.000Z

    Studies in vitro have shown that rT3 is a potent and competitive inhibitor of T4 5'-deiodination (5'D). Recent studies in vivo have shown that cerebrocortical (Cx) T4 5'D-type II (5'D-II) activity (propylthiouracil (PTU) insensitive pathway), is reduced by T4 and rT3, the latter being more potent than T3 in Cx 5'D-II suppression. Some other reports had described rT3 production in rat brain as a very active pathway of thyroid hormone metabolism. To examine the possibility that rT3 plays a physiological role in regulating Cx 5'D-II, we have explored rT3 plasma kinetics, plasma to tissue exchange, and uptake by tissues in the rat, as well as the metabolic routes of degradation and the sources of rT3 in cerebral cortex (Cx). Plasma and tissue levels were assessed with tracer (/sup 125/I)rT3. Two main compartments were defined by plasma disappearance curves in euthyroid rats (K/sub 1/ = -6.2 h-1 and K/sub 2/ = -0.75 h-1). In Cx of euthyroid rats, (/sup 125/I)rT3 peaked 10 min after iv injection, tissue to plasma ratio being 0.016 +/- 0.004 (SE). In thyroidectomized rats, plasma and tissue (/sup 125/I)rT3 concentrations were higher than in euthyroid rats, except for the Cx that did not change. PTU caused further increases in all the tissues studied, except for the Cx and the pituitaries of thyroidectomized rats. From the effect of blocking 5'D-I with PTU or reducing its activity by making the animals hypothyroid, we concluded that 5'D-I accounts for most of the rT3 clearance from plasma. In contrast, in Cx and pituitary the levels of rT3 seem largely affected by 5'D-II activity. Since the latter results suggest that plasma rT3 does not play a major role in determining rT3 levels in these tissues, we explored the sources of rT3 in Cx using (/sup 125/I)T4. The (/sup 125/I)rT3 (T4) to (/sup 125/I)T4 ratio remained constant at 0.03 from 1 up to 5 h after injection of (/sup 125/I)T4.

  17. Anesthesia with propofol induces insulin resistance systemically in skeletal and cardiac muscles and liver of rats

    SciTech Connect (OSTI)

    Yasuda, Yoshikazu; Fukushima, Yuji; Kaneki, Masao [Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospitals for Children, Harvard Medical School, Boston, MA 02114 (United States)] [Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospitals for Children, Harvard Medical School, Boston, MA 02114 (United States); Martyn, J.A. Jeevendra, E-mail: jmartyn@partners.org [Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospitals for Children, Harvard Medical School, Boston, MA 02114 (United States)] [Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Shriners Hospitals for Children, Harvard Medical School, Boston, MA 02114 (United States)

    2013-02-01T23:59:59.000Z

    Highlights: ? Propofol, as a model anesthetic drug, induced whole body insulin resistance. ? Propofol anesthesia decreased glucose infusion rate to maintain euglycemia. ? Propofol decreased insulin-mediated glucose uptake in skeletal and cardiac muscles. ? Propofol increased hepatic glucose output confirming hepatic insulin resistance. -- Abstract: Hyperglycemia together with hepatic and muscle insulin resistance are common features in critically ill patients, and these changes are associated with enhanced inflammatory response, increased susceptibility to infection, muscle wasting, and worsened prognosis. Tight blood glucose control by intensive insulin treatment may reduce the morbidity and mortality in intensive care units. Although some anesthetics have been shown to cause insulin resistance, it remains unknown how and in which tissues insulin resistance is induced by anesthetics. Moreover, the effects of propofol, a clinically relevant intravenous anesthetic, also used in the intensive care unit for sedation, on insulin sensitivity have not yet been investigated. Euglycemic hyperinsulinemic clamp study was performed in rats anesthetized with propofol and conscious unrestrained rats. To evaluate glucose uptake in tissues and hepatic glucose output [{sup 3}H]glucose and 2-deoxy[{sup 14}C]glucose were infused during the clamp study. Anesthesia with propofol induced a marked whole-body insulin resistance compared with conscious rats, as reflected by significantly decreased glucose infusion rate to maintain euglycemia. Insulin-stimulated tissue glucose uptake was decreased in skeletal muscle and heart, and hepatic glucose output was increased in propofol anesthetized rats. Anesthesia with propofol induces systemic insulin resistance along with decreases in insulin-stimulated glucose uptake in skeletal and heart muscle and attenuation of the insulin-mediated suppression of hepatic glucose output in rats.

  18. Demonstration of lactogenic receptors in rat endocrine pancreases by quantitative autoradiography

    SciTech Connect (OSTI)

    Polak, M.; Scharfmann, R.; Ban, E.; Haour, F.; Postel-Vinay, M.C.; Czernichow, P. (National Institute of Health and Medical Research, Paris (France))

    1990-09-01T23:59:59.000Z

    A direct effect of growth hormone and/or prolactin on the growth of the pancreatic beta-cell has been proposed. This study assessed the presence of human growth hormone (hGH)-binding sites in male adult rat endocrine pancreas via quantitative autoradiography. The binding of 125I-labeled hGH was evaluated by receptor autoradiography on frozen-pancreas cryostat cut sections. The sections were incubated with 125I-hGH (10(-10) M) for 75 min at room temperature, and nonspecific binding was determined in the presence of excess native hGH (5 X 10(-7) M). The specificity of the binding was assessed in competition experiments with bovine GH and ovine prolactin. The autoradiograms were quantified with a computer-assisted image-processing system. The sections were then stained to visualize the endocrine islets. Nondiabetic control and streptozocin (STZ)-injected rats were used. Our results show that (1) there is specific binding of iodinated hGH in small areas of the pancreas, which appear as the Langerhans islets when the autoradiogram and the stained sections are superimposed; (2) the specificity of hGH binding in rat islets is lactogenic; (3) the density of the hGH-binding sites in the endocrine pancreas is estimated at 4.8 fmol/mg protein, with IC50 ranging from 0.98 to 2.50 nM; and (4) binding sites may be present on the beta-cell, because specific binding disappears in STZ-injected rats. In conclusion, by use of a quantitative autoradiographic technique, we provide evidence for the presence of lactogenic receptors on rat beta-cells.

  19. Final report for Texas A&M University Group Contribution to DE-FG02-09ER25949/DE-SC0002505: Topology for Statistical Modeling of Petascale Data (and ASCR-funded collaboration between Sandia National Labs, Texas A&M University and University of Utah)

    SciTech Connect (OSTI)

    Rojas, Joseph Maurice [Texas A& M University

    2013-02-27T23:59:59.000Z

    We summarize the contributions of the Texas A\\&M University Group to the project (DE-FG02-09ER25949/DE-SC0002505: Topology for Statistical Modeling of Petascale Data - an ASCR-funded collaboration between Sandia National Labs, Texas A\\&M U, and U Utah) during 6/9/2011 -- 2/27/2013.

  20. S T U D EN T A ND EN R OLM EN T S ER V I CE S DI V IS IO N In order to assist departments and colleges with their planning cycle for 2014-15 and beyond,

    E-Print Network [OSTI]

    Saskatchewan, University of

    Page | 1 S T U D EN T A ND EN R OLM EN T S ER V I CE S DI V IS IO N In order to assist departments: Key Dates and Deadlines for 2014-15 DATE: March 28, 2014 #12;Page | 2 S T U D EN T A ND EN R OLM EN

  1. The role of constrictor prostanoids in the development of aortic coarctation-induced hypertension in male and female rats

    E-Print Network [OSTI]

    Baltzer, Wendy Irene

    2005-02-17T23:59:59.000Z

    function and arterial blood pressure (MAP) during development of aortic coarctation-induced hypertension (HT). M and F rats, (15-18 wks.) in four groups: normotensive (NT), hypertensive (HT), ovariectomized (OVX), and OVX estrogen-replaced (OE), underwent...

  2. Inactivation of the insular cortex increases anxiety-like behavior in rats : relevance to drug abuse and interoception

    E-Print Network [OSTI]

    Wolfe, Monica

    2011-01-01T23:59:59.000Z

    µl of lidocaine (or aCSF) was infused over the period of twocompared to vehicle-infused controls. It is important toplus maze. Specifically, rats infused with lidocaine showed

  3. Redescription of the enigmatic long-tailed rat Sigmodontomys aphrastus (Cricetidae: Sigmodontinae) with comments on taxonomy and natural history

    E-Print Network [OSTI]

    McCain, Christy M.; Timm, Robert M.; Weksler, Marcelo

    2007-08-01T23:59:59.000Z

    Sigmodontomys aphrastus, the long-tailed rat, is an exceedingly rare rodent species from montane regions of Central and South America of which very little is known ecologically or systematically. It has been variously ...

  4. Periadolescent oral manganese exposure affects conditioned place preference by cocaine and conditioned place aversion by lithium chloride in rats

    E-Print Network [OSTI]

    Lee, Samuel Ming Hin

    2013-02-22T23:59:59.000Z

    Manganese neurotoxicity compromises basal ganglia functions that could affect the limbic system and drug sensitivity. Male rats were orally exposed to manganese chloride (0, 100, 200 mg/kg/day Mn) for 15 days starting at postnatal day (PND) 28...

  5. Effect of dietary protein quality on fractional rates of muscle protein synthesis and catabolism in the rat

    E-Print Network [OSTI]

    Roeder, Richard Anthony

    1979-01-01T23:59:59.000Z

    EFFECT OF DIETARY PROTEIN QUALITY ON FRACTIONAL RATES OF MUSCLE PROTEIN SYNTHESIS AND CATABOLISM IN THE RAT A Thesis by RICHARD ANTHONY ROEDER Submitted to the Graduate College of Texas A8cM University in partial fulfillment... of the requirement for the degree of MASTER OF SCIENCE August 1979 Major Subject: Animal Nutrition EFFECT OF DIETARY PROTEIN QUALITY ON FRACTIONAL RATES OF MUSCLE PROTEIN SYNTHESIS AND CATABOLISM IN THE RAT A Thesis by RICHARD ANTHONY ROEDER Approved...

  6. A radiographic analysis of the effect of dietary fiber on transit time through the rat large intestine 

    E-Print Network [OSTI]

    Meacher, Mary Melanie

    1986-01-01T23:59:59.000Z

    A RADIOGRAPHIC ANALYSIS OF THE EFFECT OF DIETARY FIBER ON TRANSIT TIME THROUGH THE RAT LARGE INTESTINE A Thesis by MARY MELANIE MEACHER Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE August 1986 Major Subject. ' Nutrition A RADIOGRAPHIC ANALYSIS OF THE EFFECT OF DIETARY FIBER ON TRANSIT TIME THROUGH THB RAT LARGE INTESTINE A Thesis by MARY MELANIE MEACHER Approved as to style and content by...

  7. Effects of electrical brain stimulation on the temperature of interscapular brown adipose tissue in the adult rat

    E-Print Network [OSTI]

    Freeman, Patricia Hilliard

    1985-01-01T23:59:59.000Z

    EFFECTS OF ELECTRICAL BRAIN STIMULATI ON ON THE TEMPERATURE OF INTERSCAPULAR BROWN ADIPOSE TISSUE IN'THE ADULT RAT A Thesis by PATRICIA HILL IARD FREEMAN Submitted to the Graduate College of Texas ARM University in partial fulfillment... of the requirement for the degree of MASTER OF SCIENCE May 1985 Major Subject: Psychology EFFECTS OF ELECTRICAL BRAIN STIMULATION ON THE TEMPERATURE OF BROWN ADIPOSE TISSUE IN THE ADULT RAT A Thesis by PATRICIA HILL IARD FREEMAN Approved as to style...

  8. An investigation of the potentiating effects of ethanol on a chronic exposure of rats to 1,1,1-trichloroethane

    E-Print Network [OSTI]

    Walker, DeWayne Harold

    1973-01-01T23:59:59.000Z

    AN INVESTIGATION OF THE POTENTIATING EFFECTS OF ETHANOL ON A CHRONIC EXPOSURE OF RATS TO 1, 1&I-TRICHLOROETHANE A Thesis by DEWAYNE HAROLD WALKER Submitted to the Graduate College of Texas AFM University in partial fulfillment... of the requirement for the degree of MASTER OF SCIENCE August 1973 Major Subject: Laboratory Animal Medicine AN INVESTIGATION OF THE POTENTIATING EFFECTS OF ETHANOL ON A CHRONIC EXPOSURE OF RATS TQ 1&1, 1-TRICHLOROETHANE A Thesis by DENAYNE HAROLD WALKER...

  9. Combustion-derived flame generated ultrafine soot generates reactive oxygen species and activates Nrf2 antioxidants differently in neonatal and adult rat lungs

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    neonatal and adult rat lungs. Particle and Fibre Toxicologysensitivity of the postnatal lung to environmental insultsdevelopment of the human lung. Prog Clin Biol Res 1983, 140:

  10. Protective effects of tocotrienols against lipid-induced nephropathy in experimental type-2 diabetic rats by modulation in TGF-? expression

    SciTech Connect (OSTI)

    Siddiqui, Shabeena [Department of Biochemistry, Lipid Metabolism Laboratory, Jamia Hamdard (Hamdard University), New Delhi 110062 (India); Ahsan, Haseeb [Department of Biochemistry, Faculty of Dentistry, Jamia Millia Islamia, New Delhi 110025 (India); Khan, Mohammad Rashid [Department of Biochemistry, Lipid Metabolism Laboratory, Jamia Hamdard (Hamdard University), New Delhi 110062 (India); Siddiqui, Waseem A., E-mail: wasiddiqui01@gmail.com [Department of Biochemistry, Lipid Metabolism Laboratory, Jamia Hamdard (Hamdard University), New Delhi 110062 (India)

    2013-12-01T23:59:59.000Z

    Dyslipidemia is common in patients with diabetes mellitus (DM) and is considered a risk factor for the progression of diabetic nephropathy (DN). Hyperlipidemia and hyperglycemia act synergistically to induce renal injury. The present study was designed to investigate the protective effects of tocotrienols as tocotrienol-rich fraction (TRF) extracted from palm (PO) and rice bran oils (RBO) against lipid induced nephropathy in type-2 diabetic rats and its probable molecular mechanism. Male Wistar rats (175–200 g) were divided into four groups. The first group served as diabetic control, while the second and third groups received PO-TRF and RBO-TRF, respectively by gavage over a period of sixteen weeks post-induction of diabetes. The fourth group comprised of age-matched rats that served as normal control. The effects of TRF on serum lipid profile, oxidative stress markers, expression of TGF-?, fibronectin and collagen type IV were analyzed in the kidney of diabetic rats. Treatment with PO-TRF and RBO-TRF significantly improved glycemic status, serum lipid profile and renal function in type-2 diabetic rats. In addition, TRF supplementation down-regulated the expression of TGF-?, fibronectin and collagen type IV in the kidney of diabetic rats. Transforming growth factor-? (TGF-?) plays a critical role in progression of DN, but its modulation by tocotrienols in DN remains unexplored. TRF ameliorated lipid induced nephropathy in type-2 diabetes by its hypoglycemic, hypolipidemic and antioxidant activities as well as by modulation of TGF-? to prevent increased expression of collagen type IV and fibrinogen. We finally propose a mechanism for the expression of molecular markers that are significant in the events leading to diabetic nephropathy and its modulation by tocotrienols/TRF. - Highlights: • The nephroprotective effect of TRF in type-2 diabetic rats was investigated. • Treatment with TRF improved glycemic status, lipid profile and renal functions in rats. • TRF down-regulated the expression of TGF-?, fibronectin and collagen in rats' kidney. • TRF ameliorated nephropathy by hypoglycemic, hypolipidemic and antioxidant activity. • Tocotrienols modulate the expression of TGF-? in DN in type-2 diabetic rats.

  11. Thyroid organotypic rat and human cultures used to investigate drug effects on thyroid function, hormone synthesis and release pathways

    SciTech Connect (OSTI)

    Vickers, Alison E.M., E-mail: vickers_alison@allergan.com [Drug Safety Evaluation, Allergan Inc., 2525 Dupont Dr, Irvine CA 92612 (United States); Heale, Jason; Sinclair, John R.; Morris, Stephen; Rowe, Josh M. [Drug Safety Evaluation, Allergan Inc., 2525 Dupont Dr, Irvine CA 92612 (United States)] [Drug Safety Evaluation, Allergan Inc., 2525 Dupont Dr, Irvine CA 92612 (United States); Fisher, Robyn L. [Vitron Inc., Tucson, AZ (United States)] [Vitron Inc., Tucson, AZ (United States)

    2012-04-01T23:59:59.000Z

    Drug induced thyroid effects were evaluated in organotypic models utilizing either a rat thyroid lobe or human thyroid slices to compare rodent and human response. An inhibition of thyroid peroxidase (TPO) function led to a perturbation in the expression of key genes in thyroid hormone synthesis and release pathways. The clinically used thiourea drugs, methimazole (MMI) and 6-n-propyl-2-thioruacil (PTU), were used to evaluate thyroid drug response in these models. Inhibition of TPO occurred early as shown in rat thyroid lobes (2 h) and was sustained in both rat (24–48 h) and human (24 h) with ? 10 ?M MMI. Thyroid from rats treated with single doses of MMI (30–1000 mg/kg) exhibited sustained TPO inhibition at 48 h. The MMI in vivo thyroid concentrations were comparable to the culture concentrations (? 15–84 ?M), thus demonstrating a close correlation between in vivo and ex vivo thyroid effects. A compensatory response to TPO inhibition was demonstrated in the rat thyroid lobe with significant up-regulation of genes involved in the pathway of thyroid hormone synthesis (Tpo, Dio1, Slc5a5, Tg, Tshr) and the megalin release pathway (Lrp2) by 24 h with MMI (? 10 ?M) and PTU (100 ?M). Similarly, thyroid from the rat in vivo study exhibited an up-regulation of Dio1, Slc5a5, Lrp2, and Tshr. In human thyroid slices, there were few gene expression changes (Slc5a5, ? 2-fold) and only at higher MMI concentrations (? 1500 ?M, 24 h). Extended exposure (48 h) resulted in up-regulation of Tpo, Dio1 and Lrp2, along with Slc5a5 and Tshr. In summary, TPO was inhibited by similar MMI concentrations in rat and human tissue, however an increased sensitivity to drug treatment in rat is indicated by the up-regulation of thyroid hormone synthesis and release gene pathways at concentrations found not to affect human tissue. -- Highlights: ? Novel model of rat thyroid or human thyroid slices to evaluate pathways of injury. ? TPO inhibition by MMI or PTU altered hormone synthesis and release genes. ? Rat thyroid was more sensitive to the drug effects than human tissue.

  12. The effect of exercise and dietary fiber on the rate of gastrointestinal transit in the rat

    E-Print Network [OSTI]

    Dorr, Jerri Suzanne

    1987-01-01T23:59:59.000Z

    with cancer of the rectum. These data were compared to the life-time occupational physical exercise of 1, 43l patients with non-neoplastic, nondigestive diseases. Results indicate an increasing risk of colon cancer with increasing work years, proportion... cancer incidence, Several studies have reported changes in body composition that occur as a result of exercise (59, 67, 68). We found that the exercised rats weighed less than the non- exercised controls after they had been swimming for three weeks...

  13. Some histological manifestations in the early postnatal vitamin B?? deficient albino rat

    E-Print Network [OSTI]

    Johnson, Elmer Marshall

    1955-01-01T23:59:59.000Z

    rats were slightly smeller in sine. Ilistologically the cortex was reduced in thickness ?nd therefore in total volume There was a considerable increase in intercellular space which was often filled with connective tissue and sometimes blood..., The renal corpus- cles were characterised by an increase in the space between Bowman's capsule and the glomerulus (I~'ig, 7). The loops of Henle in the medul- lary region showed reduoed lumina. The convoluted tubules (pr obably due to the fatty...

  14. The Relation of Lime and Phosphoric Acid to the Growth and Bone Development of White Rats.

    E-Print Network [OSTI]

    Blum, J. K. (Joseph Kelly)

    1931-01-01T23:59:59.000Z

    LIBRARY, A & M COLLEGE. CAMPUS. TEXAS AGRICULTURAL EXPERIMENT STATION A. B. CONNER, DIRECTOR College Station, Brazos County, Texas BULLETIN NO. 441 DECEMBER, 1931 DIVISION OF CHEMISTRY The Relation of Lime and Phosphoric Acid to the Growth... and Bone Development of White Rats 2 ., .t .I* .-. /.' AGRICULTURAL AND MECHANICAL COLLEGE OF TEXAS--. .. T. 0. WALTON, President ..- STATION STAFF+ ADMINISTRATION: VETERINARY SCIENCE: A B. CONNER M S. Director *M. FRANCIS, D. V. M., Chief. R: E...

  15. The gestation-dependent variation in aflatoxin B? activation by rat liver microsomes 

    E-Print Network [OSTI]

    Wall, Florence Elizabeth

    1989-01-01T23:59:59.000Z

    Microsomes. (May t 989) Florence Elizabeth Wall, B. A. , Trinity University Chair of Advisory Committee: Dr. T. Rick Irvin The metabolic capacity of maternal rat liver microsomes to bioactivate a model teratogen, AFBt, was examined through a series... BCA (bicinchoninic acid) protein assay. . . . . . . . . . Microsomal metabolism assay . DNA isolation . Liquid scintillation counting . Sa/mone//a /mammalian-microsome mutagenicity assay Postimplantation embryo culture assay . . RESULTS Page...

  16. Effects of chronic cadmium exposure on the conditioned reinforcing properties of morphine and fentanyl in rats

    E-Print Network [OSTI]

    Miller, Dennis K

    1997-01-01T23:59:59.000Z

    &M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved as to style and content by: ck R. Nation (C ir of Committee) Gerald D. Frye (Member) Paul J. Wellman (Member) Paul J. Wellman (Head of Department... the metal (Nation, Livermore, Bratton, & Schenk, 1996). A similar attenuation was shown with repeated cocaine exposure--the development of locomotor sensitization. Rats that received chronic cadmium exposure required more cocaine administration sessions...

  17. Effects of Nicotine Exposure on In Vitro Metabolism of Chlorpyrifos in Male Sprague-Dawley Rats

    SciTech Connect (OSTI)

    Lee, Sookwang; Busby, Andrea L.; Timchalk, Charles; Poet, Torka S.

    2009-01-30T23:59:59.000Z

    Chlorpyrifos (CPF) is a common organophosphate (OP) insecticide which is metabolized by CYP450s to the neurotoxic metabolite, chlorpyrifos-oxon (CPF-oxon) and a non-toxic metabolite, 3,5,6-trichloro-2-pyridinol (TCP). The objective of this study was to quantify the effect of repeated in vivo nicotine exposures on CPF in vitro metabolism and marker substrate activities in rats. Male Sprague-Dawley rats were dosed subcutaneously with 1 mg nicotine/kg/, for up to 10 days. Animals showed signs of cholinergic crisis after the initial nicotine doses, but exhibited adaptation after a couple days of treatment. Rats were sacrificed on selected days 4 or 24 hr after the last nicotine-treatment. While CYP450 reduced CO spectra were not different across the treatments, the single nicotine dose group showed a 2-fold increase in CYP2E1 marker substrate (p-nitrophenol) activity 24 hr after a single nicotine treatment compared to saline controls. Conversely, repeated nicotine treatments resulted in decreased EROD marker substrate activity 4 hr after the 7th day of treatment. CPF-oxon Vmax and Km did not show significant changes across the different nicotine treatment groups. The Vmax describing the metabolism of CPF to TCP was increased on all groups (days 1, 7, and 10) 24 hr after nicotine treatment but were unchanged 4 hr after nicotine treatment. Results of this in vitro study suggest that repeated nicotine exposure (i.e., from smoking) may result in altered metabolism of CPF. Future in vivo experiments based on these results will be conducted to ascertain the impact of in vivo nicotine exposures on CPF metabolism in rats.

  18. Iron supplementation at high altitudes induces inflammation and oxidative injury to lung tissues in rats

    SciTech Connect (OSTI)

    Salama, Samir A., E-mail: salama.3@buckeyemail.osu.edu [High Altitude Research Center, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia); Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11751 (Egypt); Department of Pharmacology and GTMR Unit, College of Clinical Pharmacy, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia); Omar, Hany A. [Department of Pharmacology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514 (Egypt); Maghrabi, Ibrahim A. [Department of Clinical Pharmacy, College of Clinical Pharmacy, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia); AlSaeed, Mohammed S. [Department of Surgery, College of Medicine, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia); EL-Tarras, Adel E. [High Altitude Research Center, Taif University, Al-Haweiah, Taif 21974 (Saudi Arabia)

    2014-01-01T23:59:59.000Z

    Exposure to high altitudes is associated with hypoxia and increased vulnerability to oxidative stress. Polycythemia (increased number of circulating erythrocytes) develops to compensate the high altitude associated hypoxia. Iron supplementation is, thus, recommended to meet the demand for the physiological polycythemia. Iron is a major player in redox reactions and may exacerbate the high altitudes-associated oxidative stress. The aim of this study was to explore the potential iron-induced oxidative lung tissue injury in rats at high altitudes (6000 ft above the sea level). Iron supplementation (2 mg elemental iron/kg, once daily for 15 days) induced histopathological changes to lung tissues that include severe congestion, dilatation of the blood vessels, emphysema in the air alveoli, and peribronchial inflammatory cell infiltration. The levels of pro-inflammatory cytokines (IL-1?, IL-6, and TNF-?), lipid peroxidation product and protein carbonyl content in lung tissues were significantly elevated. Moreover, the levels of reduced glutathione and total antioxidant capacity were significantly reduced. Co-administration of trolox, a water soluble vitamin E analog (25 mg/kg, once daily for the last 7 days of iron supplementation), alleviated the lung histological impairments, significantly decreased the pro-inflammatory cytokines, and restored the oxidative stress markers. Together, our findings indicate that iron supplementation at high altitudes induces lung tissue injury in rats. This injury could be mediated through excessive production of reactive oxygen species and induction of inflammatory responses. The study highlights the tissue injury induced by iron supplementation at high altitudes and suggests the co-administration of antioxidants such as trolox as protective measures. - Highlights: • Iron supplementation at high altitudes induced lung histological changes in rats. • Iron induced oxidative stress in lung tissues of rats at high altitudes. • Iron increased the levels of IL-1?, IL-6 and TNF-? in lung tissues at high altitudes. • Trolox alleviated the iron-induced histological and biochemical changes to the lungs.

  19. Metabolism of the geometric isomers of phosphamidon in insects and rats

    E-Print Network [OSTI]

    Grabbe, Rolland Ralph

    1966-01-01T23:59:59.000Z

    Metabolism of the Geometric Isomers of Phosphamldon ln Insects and Rats, Nay 1955. Rolland R, Grabbe, B. S. , Iowa State Dnlverslty Directed by: Dr. Don L, Bull Abstract Phosphamldon (2-chloro 2 dlethylcarbamoyl I methylvlnyl dimethyl phosphate) ls a... with phosphamldon that was radlolabeled either with C at the methyl-vinyl and carbonyl carbon atoms or with P 32 Slightly more N deethyl phosphamldon (2 ohloro 2-ethylcarbamoyl I-methylvlnyl dimethyl phosphate) was formed ln Insects treated with cls...

  20. A study of the effect of restricted diets in the male albino rat 

    E-Print Network [OSTI]

    Griffin, Travis Barton

    1961-01-01T23:59:59.000Z

    26 Sections of the Testes Stained with Hematwylin and Eosin 30 CHAPTER l INT RODUCT ION During the past 30 years there has been rr, uch invssti~tion of the various effects of low caloric intake upon laboratory anirrals, This has come about... in decreased growth rats due to decreased food %take, it becomes necessary to differentiate between the various effects and thereby account for those due to caloric decrease. The problem is very coxrplex and cannot becozr. s completely solved until...

  1. Increased activity of tyrosine hydroxylase in the cerebellum of the x-irradiated dystonic rat

    SciTech Connect (OSTI)

    Dopico, A.M.; Rios, H.; Mayo, J.; Zieher, L.M. (Departamentos de Biologia Celular e Histologia y de Farmacologia y Toxicologia, Facultad de Medicina, Universidad de Buenos Aires, (Argentina))

    1990-08-01T23:59:59.000Z

    The exposure of the cephalic end of rats to repeated doses of x-irradiation (150 rad) immediately after birth induces a long-term increase in the noradrenaline (NA) content of cerebellum (CE) (+ 37.8%), and a decrease in cerebellar weight (65.2% of controls), which results in an increased NA concentration (+ 109%). This increase in the neurotransmitter level is accompanied by a dystonic syndrome and histological abnormalities: Purkinje cells (the target cells for NA afferents to CE) fail to arrange in a characteristic monolayer, and their primary dendritic tree appears randomly oriented. The injection of reserpine 0.9 and 1.2 mg/kg ip to adult rats for 18 h depletes cerebellar NA content in both controls (15.7 {plus minus} 4 ng/CE and 2.8 {plus minus} 1.5 ng/CE, respectively) and x-irradiated rats (17.1 {plus minus} 1 ng/CE and 8.3 {plus minus} 2 ng/CE, respectively). The activity of tyrosine hydroxylase (TH) in CE of adult rats, measured by an in vitro assay, is significantly increased in neonatally x-irradiated animals when compared to age-matched controls (16.4 {plus minus} 1.4 vs 6.32 {plus minus} 0.6 nmol CO2/h/mg prot., p less than 0.01). As observed for NA levels, a net increase in TH activity induced by the ionizing radiation is also measured: 308.9 {plus minus} 23.8 vs 408.2 {plus minus} 21.5 nmol CO2/h/CE, p less than 0.01 (controls and x-treated, respectively). These results suggest that x-irradiation at birth may induce an abnormal sprouting of noradrenergic afferents to CE. The possibility that these changes represent a response of the NA system to the dystonic syndrome is discussed.

  2. The effect of stress on the pulsatile pattern of luteinizing hormone in the ovariectomized rat

    E-Print Network [OSTI]

    Farr, Kathryn Louise

    1982-01-01T23:59:59.000Z

    as a model. The first objective of this study was to develop a method to accurately monitor the pattern of pituitary LH release in the ovari- ectomized rat, Using this method the second objective was to deter- mine the influence of two types... is attached to the anterior pituitary qland by the pituitary stalk. Within the pituitary stalk rests the vascular pathway that transports LHRH to the anterior pituitary. This unique vascular network is termed the hypothalamic-hypophysea1 portal system. 13...

  3. Rat lymphoma cell bioassay for prolactin: observations on its use and comparison with radioimmunoassay

    SciTech Connect (OSTI)

    Dawson, D.M.; Sensui, N.; Haisenleder, D.H.; Gala, R.R.

    1982-12-27T23:59:59.000Z

    The rat Nb/sub 2/ node lymphoma cell bioassay (BA) for prolactin (PRL) was validated for use in our laboratories. During the course of this validation we observed that rat prolactin (NIAMDD-RP-1) stimulated cell division by as much as 16.5 fold over the range of 0.04 to 40.0 ng/ml at the end of 72 hours of incubation. We also observed a dose related increase in the size of the lymphoma cells. Prolactin concentrations in rat plasma, serum, anterior pituitary (AP) homogenates and milk were measured by both radioimmunoassay (RIA) and BA. In individual BA's there was parallelism between samples and standard; but when several dilutions of the same plasma and pituitary homogenates were assayed repeatedly, higher PRL levels were consistently observed for the more concentrated samples. At low or moderate levels of plasma PRL there was excellent agreement between RIA and BA; however, at high levels plasma PRL bioactivity exceeded radioimmunoactivity by a small, but significant, amount. A comparison of pituitary PRL concentrations measured by RIA and BA were in good agreement when homogenization was done at pH 10.6. However, when homogenization was done at pH 7.6, slightly but significantly more PRL was extracted when assayed by BA than when assayed by RIA.

  4. Synthesis, structure and properties of the oxychalcogenide series A{sub 4}O{sub 4}TiSe{sub 4} (A=Sm, Gd, Tb, Dy, Ho, Er and Y)

    SciTech Connect (OSTI)

    Tuxworth, A.J.; Evans, J.S.O., E-mail: john.evans@durham.ac.uk

    2014-02-15T23:59:59.000Z

    Seven oxyselenide materials have been synthesised with composition A{sub 4}O{sub 4}TiSe{sub 4} (A=Sm, Gd–Er, Y) via solid state reactions of A{sub 2}O{sub 3}, TiSe{sub 2} and Se at 900 °C. They are all isostructural with Gd{sub 4}O{sub 4}TiSe{sub 4}. Structures have been refined from powder X-ray diffraction data and have monoclinic C2/m symmetry with unit cell parameters of a?15.7 Å, b?3.75 Å, c?9.65 Å and ??117.5°. They contain infinite ribbons of edge-sharing A{sub 4}O and A{sub 3}TiO tetrahedra 4 units wide, which are linked by chains of TiSe{sub 4}O{sub 2} edge-sharing octahedra. Compositions A=Gd–Ho, Y are semiconductors with conductivities 1–3 Sm{sup ?1} at 300 K, with electronic band gaps of between 0.25 and 0.37 eV. Magnetic susceptibility is reported from 1.8 K to 300 K for compositions A=Gd–Ho. Rare earth moments appear to order antiferromagnetically at low temperatures with Gd and Tb showing evidence of ferromagnetism due to spin canting over a narrow temperature range close to T{sub N}. - Graphical abstract: Illustration of the A{sub 4}O{sub 4}TiSe{sub 4} crystal structure (C2/m symmetry), A{sub 4}O and A{sub 3}TiO edge sharing tetrahedral ribbons in red, chains of edge-sharing TiSe{sub 4}O{sub 2} in blue. Rare earth=green, titanium=blue, selenium=yellow, and oxygen=red. Display Omitted - Highlights: • Seven materials with A{sub 4}O{sub 4}TiSe{sub 4} (A=Sm, Gd–Er, Y) have been synthesised as bulk phases for the first time. • Materials are semiconductors and order antiferromagnetically at ?4 K. • Structure contains M{sub 4}O tetrahedral ribbons and TiSe{sub 4}O{sub 2} 1D octahedral chains.

  5. TRIGEMINAL UPTAKE AND CLEARANCE OF INHALED MANGANESECHLORIDE IN RATS AND MICE

    SciTech Connect (OSTI)

    Lewis, J; Bench, G; Myers, O; Tinner, B; Staines, W; Barr, E; Divine, K K; Barrington, W; Karlsson, J

    2003-12-09T23:59:59.000Z

    Inhaled manganese (Mn) can enter the olfactory bulbs via the olfactory epithelium, and can then be further transported trans-synaptically to deeper brain structures. In addition to olfactory neurons, the nasal cavity is innervated by the maxillary division of the trigeminal nerve that projects to the spinal trigeminal nucleus. Direct uptake and transport of inhaled metal particles in the trigeminal system has not been investigated previously. We studied the uptake, deposition, and clearance of soluble Mn in the trigeminal system following nose-only inhalation of environmentally relevant concentrations. Rats and mice were exposed for 10 days (6 hours/day, 5 days/week) to air or MnCl2 aerosols containing 2.3 {+-} 1.3mg Mn/m{sup 3} with mass median aerodynamic diameter (MMAD) of 3.1 {+-} 1.4 {micro}m for rats and 2.0 {+-} 0.09 mg Mn/m{sup 3} MnCl{sup 2} with MMAD of 1.98 {+-} 0.12 {micro}m for mice. Mn concentrations in the trigeminal ganglia and spinal trigeminal nucleus were measured 2 hours (0 day), 7, 14, or 30 days post-exposure using Proton Induced X-ray Emission (PIXE). Manganese-exposed rats and mice showed statistically elevated levels of Mn in trigeminal ganglia 0, 7 and 14 days after the 10 day exposure period when compared to control animals. The Mn concentration gradually decreased over time with a clearance rate (t{sub 1/2}) of 7-8 days. Rats and mice were similar in both average accumulated Mn levels in trigeminal ganglia and in rates of clearance. We also found a small but significant elevation of Mn in the spinal trigeminal nucleus of mice 7 days post-exposure and in rats 0 and 7 days post-exposure. Our data demonstrate that the trigeminal nerve can serve as a pathway for entry of inhaled Mn to the brain in rodents following nose-only exposure and raise the question of whether entry of toxicants via this pathway may contribute to development of neurodegenerative diseases.

  6. Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague-Dawley rats

    SciTech Connect (OSTI)

    Doerge, Daniel R., E-mail: daniel.doerge@fda.hhs.gov [Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079 (United States); Twaddle, Nathan C.; Vanlandingham, Michelle [Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079 (United States); Brown, Ronald P. [Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD (United States); Fisher, Jeffrey W. [Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079 (United States)

    2011-09-15T23:59:59.000Z

    Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. The presence of BPA metabolites in urine of > 90% of Americans aged 6-60 suggests ubiquitous and frequent exposure in the range of 0.02-0.2 {mu}g/kg bw/d (25th-95th percentiles). The current study used LC/MS/MS to measure placental transfer and concentrations of aglycone (receptor-active) and conjugated (inactive) BPA in tissues from Sprague-Dawley rats administered deuterated BPA (100 {mu}g/kg bw) by oral and IV routes. In adult female rat tissues, the tissue/serum concentration ratios for aglycone BPA ranged from 0.7 in liver to 5 in adipose tissue, reflecting differences in tissue perfusion, composition, and metabolic capacity. Following IV administration to dams, placental transfer was observed for aglycone BPA into fetuses at several gestational days (GD), with fetal/maternal serum ratios of 2.7 at GD 12, 1.2 at GD 16, and 0.4 at GD 20; the corresponding ratios for conjugated BPA were 0.43, 0.65, and 3.7. These ratios were within the ranges observed in adult tissues and were not indicative of preferential accumulation of aglycone BPA or hydrolysis of conjugates in fetal tissue in vivo. Concentrations of aglycone BPA in GD 20 fetal brain were higher than in liver or serum. Oral administration of the same dose did not produce measurable levels of aglycone BPA in fetal tissues. Amniotic fluid consistently contained levels of BPA at or below those in maternal serum. Concentrations of aglycone BPA in tissues of neonatal rats decreased with age in a manner consistent with the corresponding circulating levels. Phase II metabolism of BPA increased with fetal age such that near-term fetus was similar to early post-natal rats. These results show that concentrations of aglycone BPA in fetal tissues are similar to those in other maternal and neonatal tissues and that maternal Phase II metabolism, especially following oral administration, and fetal age are critical in reducing exposures to the fetus. - Highlights: > Studies of BPA in rat tissues showed placental transfer and fetal metabolism. > Levels in fetus are similar to maternal tissues. > Fetal metabolism can reduce levels.

  7. DOE 5700.6C, 10CFR830.120, DOE-ER-STD-6001-92, and Covey-based TQM: A historical perspective on current issues in research environments

    SciTech Connect (OSTI)

    Bodnarczuk, M.

    1994-06-01T23:59:59.000Z

    Three years ago there were no standards or published guidelines for quality in research environments. Today, one standard has been published, and three guidelines documents are in final draft form and about to be published. In this paper, I describe the events that led to the writing of DOE 5700.6C, 10CFR830.120, and DOE-ER-STD-6001-92, focusing on the cultural barriers that arose (largely in the community of quality assurance professionals) during this process. I go on to describe why I believe that implementing DOE 5700.6C and 10CFR830.120 must be pushed even further toward an approach that embodies the Malcolm Baldrige National Quality Award and why even this is not far enough. The reason is because the most crucial aspect of successfully implementing a quality initiative is to base it on a cohesive, unified foundation of organizational and individual values and beliefs. Stephen Covey`s 7 Habits of Highly Effective People and Principle Centered Leadership provide such a foundations.

  8. Modeling of optical amplifier waveguide based on silicon nanostructures and rare earth ions doped silica matrix gain media by a finite-difference time-domain method: comparison of achievable gain with Er3+ or Nd3+ ions dopants

    E-Print Network [OSTI]

    Cardin, Julien; Dufour, Christian; Gourbilleau, Fabrice

    2015-01-01T23:59:59.000Z

    A comparative study of the gain achievement is performed in a waveguide optical amplifier whose active layer is constituted by a silica matrix containing silicon nanograins acting as sensitizer of either neodymium ions (Nd 3+) or erbium ions (Er 3+). Due to the large difference between population levels characteristic times (ms) and finite-difference time step (10 --17 s), the conventional auxiliary differential equation and finite-difference time-domain (ADE-FDTD) method is not appropriate to treat such systems. Consequently, a new two loops algorithm based on ADE-FDTD method is presented in order to model this waveguide optical amplifier. We investigate the steady states regime of both rare earth ions and silicon nanograins levels populations as well as the electromagnetic field for different pumping powers ranging from 1 to 10 4 mW.mm-2. Furthermore, the three dimensional distribution of achievable gain per unit length has been estimated in this pumping range. The Nd 3+ doped waveguide shows a higher gross...

  9. Final Report for U.S. DOE GRANT No. DEFG02-96ER41015 November 1, 2010 - April 30, 2013 entitled HIGH ENERGY ACCELERATOR AND COLLIDING BEAM USER GROUP at the UNIVERSITY of MARYLAND

    SciTech Connect (OSTI)

    Hadley, Nicholas [University of Maryland College Park; Jawahery, Abolhassan [University of Maryland College Park; Eno, Sarah C [University of Maryland College Park; Skuja, Andris [University of Maryland College Park; Baden, Andrew [University of Maryland College Park; Roberts, Douglas [University of Maryland College Park

    2013-07-26T23:59:59.000Z

    We have #12;finished the third year of a three year grant cycle with the U.S. Department of Energy for which we were given a #12;five month extension (U.S. D.O.E. Grant No. DEFG02-96ER41015). This document is the fi#12;nal report for this grant and covers the period from November 1, 2010 to April 30, 2013. The Maryland program is administered as a single task with Professor Nicholas Hadley as Principal Investigator. The Maryland experimental HEP group is focused on two major research areas. We are members of the CMS experiment at the LHC at CERN working on the physics of the Energy Frontier. We are also analyzing the data from the Babar experiment at SLAC while doing design work and R&D towards a Super B experiment as part of the Intensity Frontier. We have recently joined the LHCb experiment at CERN. We concluded our activities on the D#31; experiment at Fermilab in 2009.

  10. Dosimetry considerations in the enhanced sensitivity of male Wistar rats to chronic ethylene glycol-induced nephrotoxicity

    SciTech Connect (OSTI)

    Corley, R.A. [Battelle Pacific Northwest Division, Richland, WA 99352 (United States)], E-mail: rick.corley@pnl.gov; Wilson, D.M. [Dow Chemical Company, Midland, MI 48674 (United States); Hard, G.C. [Tairua, 2853 (New Zealand); Stebbins, K.E.; Bartels, M.J. [Dow Chemical Company, Midland, MI 48674 (United States); Soelberg, J.J. [Battelle Pacific Northwest Division, Richland, WA 99352 (United States); Dryzga, M.D. [Dow Chemical Company, Midland, MI 48674 (United States); Gingell, R. [Shell Oil Company, Houston, TX 77002 (United States); McMartin, K.E. [Louisiana State University Health Sciences Center, Shreveport, LA 71130 (United States); Snellings, W.M. [Dow Chemical Company, Midland, MI 48674 (United States)

    2008-04-15T23:59:59.000Z

    Male Wistar rats have been shown to be the most sensitive sex, strain and species to ethylene glycol-induced nephrotoxicity in subchronic studies. A chronic toxicity and dosimetry study was therefore conducted in male Wistar rats administered ethylene glycol via the diet at 0, 50, 150, 300, or 400 mg/kg/day for up to twelve months. Subgroups of animals were included for metabolite analysis and renal clearance studies to provide a quantitative basis for extrapolating dose-response relationships from this sensitive animal model in human health risk assessments. Mortality occurred in 5 of 20 rats at 300 mg/kg/day (days 111-221) and 4 of 20 rats at 400 mg/kg/day (days 43-193), with remaining rats at this dose euthanized early (day 203) due to excessive weight loss. Increased water consumption and urine volume with decreased specific gravity occurred at 300 mg/kg/day presumably due to osmotic diuresis. Calculi (calcium oxalate crystals) occurred in the bladder or renal pelvis at {>=} 300 mg/kg/day. Rats dying early at {>=} 300 mg/kg/day had transitional cell hyperplasia with inflammation and hemorrhage of the bladder wall. Crystal nephropathy (basophilic foci, tubule or pelvic dilatation, birefringent crystals in the pelvic fornix, or transitional cell hyperplasia) affected most rats at 300 mg/kg/day, all at 400 mg/kg/day, but none at {<=} 150 mg/kg/day. No significant differences in kidney oxalate levels, the metabolite responsible for renal toxicity, were observed among control, 50 and 150 mg/kg/day groups. At 300 and 400 mg/kg/day, oxalate levels increased proportionally with the nephrotoxicity score supporting the oxalate crystal-induced nephrotoxicity mode of action. No treatment-related effects on the renal clearance of intravenously infused {sup 3}H-inulin, a marker for glomerular filtration, and {sup 14}C-oxalic acid were observed in rats surviving 12 months of exposure to ethylene glycol up to 300 mg/kg/day. In studies with naive male Wistar and F344 rats (a less sensitive strain), a significant difference was observed in oxalate clearances between young rats (i.e. Wistar clearance < F344) but not in age-matched old rats. Regardless, the ratios of oxalate:inulin clearances in these two strains of rats, including those exposed to ethylene glycol, were all < 1, suggesting that a fraction of the filtered oxalate is reabsorbed. Other species, including humans, typically have clearance ratios > 1 and are more effective at clearing oxalic acid by both glomerular filtration and active secretion. Thus, the lower renal clearance and kidney accumulation of oxalates in male Wistar rats enhances their sensitivity, which will be a factor in human risk assessments. The benchmark dose values (BMD05, BMDL05) were 170 mg/kg/day and 150 mg/kg/day for nephropathy, and 170 mg/kg/day and 160 mg/kg/day for birefringent crystals, using incidence times severity data in each case. The NOAEL of 150 mg/kg/day is the same as that reported after 16-week exposure and appears to be a threshold dose below which no renal toxicity occurs, regardless of exposure duration.

  11. Physiology & Behavior, Vol. 26, pp. 783-786. Pergamon Press and Brain Research Pub!., 1981. Printed in the U.S.A. Preference for Natural Odors in Rat Pups

    E-Print Network [OSTI]

    Galef Jr., Bennett G.

    in the U.S.A. Preference for Natural Odors in Rat Pups: Implications of a Failure to Replicatel BENNETT G December 1980 GALEF, B. G., JR. Preference for natural odors in rat pups: Implications of a failure minor changes in the diet on which a rat dam is maintained can have profound effects

  12. PET Imaging of Brain 5-HT1A Receptors in Rat In Vivo with 18F-FCWAY and Improvement by

    E-Print Network [OSTI]

    Shen, Jun

    PET Imaging of Brain 5-HT1A Receptors in Rat In Vivo with 18F-FCWAY and Improvement by Successful)cyclohexanecarboxamide) is useful in clinical research with PET for measuring serotonin 1A (5-HT1A) re- ceptor densities in brain applicability to measuring brain regional 5-HT1A receptor densities. Methods: PET of rat head after

  13. Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of

    E-Print Network [OSTI]

    Hammock, Bruce D.

    , and at 180 min after reperfusion. Neuroprotective effects of t-AUCB were evaluated in primary rat neuronal-AUCB may exert its neuroprotective effects by affecting multiple components of neurovascular unit including]-benzoic acid is neuroprotective in rat model of ischemic stroke Jafar Sadik B. Shaik,1 Muzamil Ahmad,3 Wenjin

  14. Highly accurate quantification of proton MR spectroscopy in rat brain in vivo at 16.4 T , D. Z. Balla1

    E-Print Network [OSTI]

    Highly accurate quantification of proton MR spectroscopy in rat brain in vivo at 16.4 T S-T. Hong1, Minnesota, United States Introduction Localized 1 H MR spectroscopy is an efficient tool capable Wistar rats that were anaesthetized by inhalation of 1.5-2 % concentration of isoflurane. All MR

  15. Control of the level of unusual estrogen-binding protein in rat liver by sex steroids and the pituitary

    SciTech Connect (OSTI)

    Smirnova, O.V.; Rozen, V.B.; Vishnyakova, T.G.

    1986-02-01T23:59:59.000Z

    This paper studies the role of sex steriods and the pituitary in regulation of the unusual estrogen-binding protein (UEBP) level in male rat liver. The concentration of E/sub 2/-binding sites of UEBP in the liver cytosol was determined by measuring binding of a minimal addition of 2,4,6,7-tritium-E/sub 2/, with specific radioactivity of 98-100 Ci/mmole. Data on the effect of hypophysectomy on the UEBP level in the liver of different groups of rats are presented. The presence of comparable quantities of E/sub 2/ and androgens in rats of both sexes is evidence of the existence of a fine mechanism of combined regulation of the UEBP concentration under natural conditions that reflect changes in the absolute E/sub 2/ or androgen levels or in the ratio between them.

  16. Localization of atrial natriuretic peptide mRNA and immunoreactivity in the rat heart and human atrial appendage

    SciTech Connect (OSTI)

    Hamid, Q.; Wharton, J.; Terenghi, G.; Hassall, C.J.S.; Aimi, J.; Taylor, K.M.; Nakazato, H.; Dixon, J.E.; Burnstock, G.; Polak, J.M.

    1987-10-01T23:59:59.000Z

    The localization of mRNA encoding preproatrial natriuretic peptide was investigated in tissue sections and cultures of rat heart and in sections of human right atrial appendage using the technique of in situ hybridization with /sup 32/P- and /sup 35/S-labeled RNA probes. Rat atrial natriuretic peptide (ANP) transcripts were demonstrated in numerous atrial myocytes and, to a lesser extent, in ventricular myocytes in both tissue sections and newborn rat heart cultures. These findings are consistent with those obtained by RNA blot analysis of rat heart total RNA, indicating that a single prepro-ANP transcript of approx. 900 nucleotides was present in the ventricles as well as the atria. Using a /sup 35/S-labeled RNA probe for human ANP mRNA, ANP transcripts were also localized to the majority of myocytes in the human right atrial appendage. Only background levels of autoradiographic labeling were obtained when RNA probes identical to the coding sequence of rat or human ANP mRNA were used. A close correlation was found between the distribution of ANP immunoreactivity and prepro-ANP mRNA in these preparations. These results provide unequivocal evidence for the expression of the ANP gene in the rat ventricles, as well as the atria, because myocytes in these tissues have been established as the sites of both ANP localization and precursor biosynthesis. The combined use of cardiac cultures and in situ hybridization may be of value in future studies investigating the regulation of ANP synthesis in cardiac myocytes.

  17. RatBot: anti-enumeration peer-to-peer botnets

    SciTech Connect (OSTI)

    Yan, Guanhua [Los Alamos National Laboratory; Eidenbenz, Stephan [Los Alamos National Laboratory; Chen, Songqing [GEORGE MASON UNIV.

    2010-01-01T23:59:59.000Z

    Botnets have emerged as one of the most severe cyber threats in recent years. To obtain high resilience against a single point of failure, the new generation of botnets have adopted the peer-to-peer (P2P) structure. One critical question regarding these P2P botnets is: how big are they indeed? To address this question, researchers have proposed both actively crawling and passively monitoring methods to enumerate existing P2P botnets. In this work, we go further to explore the potential strategies that botnets may have to obfuscate their true sizes. Towards this end, this paper introduces RatBot, a P2P botnet that applies some statistical techniques to defeat existing P2P botnet enumeration methods. The key ideas of RatBot are two-fold: (1) there exist a fraction of bots that are indistinguishable from their fake identities, which are spoofing IP addresses they use to hide themselves; (2) we use a heavy-tailed distribution to generate the number of fake identities for each of these bots so that the sum of observed fake identities converges only slowly and thus has high variation. We use large-scale high-fidelity simulation to quantify the estimation errors under diverse settings, and the results show that a naive enumeration technique can overestimate the sizes of P2P botnets by one order of magnitude. We believe that our work reveals new challenges of accurately estimating the sizes of P2P botnets, and hope that it will raise the awareness of security practitioners with these challenges. We further suggest a few countermeasures that can potentially defeat RatBot's anti-enumeration scheme.

  18. Effect of intranasal manganese administration on neurotransmission and spatial learning in rats

    SciTech Connect (OSTI)

    Blecharz-Klin, Kamilla; Piechal, Agnieszka; Joniec-Maciejak, Ilona; Pyrzanowska, Justyna; Widy-Tyszkiewicz, Ewa, E-mail: etyszkiewicz@wum.edu.pl

    2012-11-15T23:59:59.000Z

    The effect of intranasal manganese chloride (MnCl{sub 2}·4H{sub 2}O) exposure on spatial learning, memory and motor activity was estimated in Morris water maze task in adult rats. Three-month-old male Wistar rats received for 2 weeks MnCl{sub 2}·4H{sub 2}O at two doses the following: 0.2 mg/kg b.w. (Mn0.2) or 0.8 mg/kg b.w. (Mn0.8) per day. Control (Con) and manganese-exposed groups were observed for behavioral performance and learning in water maze. ANOVA for repeated measurements did not show any significant differences in acquisition in the water maze between the groups. However, the results of the probe trial on day 5, exhibited spatial memory deficits following manganese treatment. After completion of the behavioral experiment, the regional brain concentrations of neurotransmitters and their metabolites were determined via HPLC in selected brain regions, i.e. prefrontal cortex, hippocampus and striatum. ANOVA demonstrated significant differences in the content of monoamines and metabolites between the treatment groups compared to the controls. Negative correlations between platform crossings on the previous platform position in Southeast (SE) quadrant during the probe trial and neurotransmitter turnover suggest that impairment of spatial memory and cognitive performance after manganese (Mn) treatment is associated with modulation of the serotonergic, noradrenergic and dopaminergic neurotransmission in the brain. These findings show that intranasally applied Mn can impair spatial memory with significant changes in the tissue level and metabolism of monoamines in several brain regions. -- Highlights: ? Intranasal exposure to manganese in rats impairs spatial memory in the water maze. ? Regional changes in levels of neurotransmitters in the brain have been identified. ? Cognitive disorder correlates with modulation of 5-HT, NA and DA neurotransmission.

  19. Rat enterohepatic circulation and intestinal distribution of enterally infused thyroid hormones

    SciTech Connect (OSTI)

    DiStefano, J.J. III; Sternlicht, M.; Harris, D.R.

    1988-11-01T23:59:59.000Z

    The enterohepatic circulation (recycling), intestinal (gut) distribution, metabolism, and excretion of enterally infused thyroid hormones were studied in the intact rat under approximately normal physiological steady state conditions. Rats with 7-day osmotic minipumps implanted ip received constant intraduodenal infusions to steady state of very small trace doses of either 125I-labeled T3 (T3*) or T4 (T4*). Enterohepatic and other pathways remained open to normal function, and in particular, there was no biliary diversion or ligation. Complete feces and urine were collected daily, to assess daily distributions of radioactivity and establishment of the steady state, which occurred by day 3. On day 7, rats were anesthetized, blood was sampled, whole intestine and minipumps were removed, and the gut was separated into six segments. Fecal samples and the contents of each gut section were homogenized, ethanol extracted, evaporated, and reconstituted in NaOH for quantitative aqueous chromatography along with infusate, urine, and plasma samples, on Sephadex G-25 columns. No T3* or T4* was found in urine, but feces contained 39% of the T3* infused and 36% of the T4* infused in steady state. Statistically significant amounts of both T3* and T4* in systemic plasma on day 7 clearly indicated absorption of the hormones from the intestine, distinctly demonstrating an enterohepatic circulation of T3 and T4 under experimental conditions closely approximating the physiological steady state. This also establishes the intestine (with its contents) as an exchangeable hormone pool, physiologically internal to the system regulating thyroid hormones and their distribution. Gut contents contained 52 times more T3* and 4.34 times more T4* than corresponding plasma pools in steady state.

  20. The effects of a marginal intake of magnesium with soy protein concentrate on growth, gestation, and lactation in the rat 

    E-Print Network [OSTI]

    McLaughlin, Cynthia Anne

    1986-01-01T23:59:59.000Z

    THE EFFECTS OF A MARGINAL INTAKE OF MAGNESIUM WITH SOY PROTEIN CONCENTRATE ON GROWTH, GESTATION, AND LACTATION IN THE RAT A Thesis by CYNTHIA ANNE MCLAUGHLIN Submitted to the Graduate College of Texas A&M University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE May 19B6 Major Subject: Nutrrtion THE EFFECTS OF A MARGINAL INTAKE OF MAGNESIUM WITH SOY PROTEIN CONCENTRATE ON GROWTH, GESTATION, AND LACTATION IN THE RAT A Thesis by CYNTHIA ANNE MCLAUGHLIN Approved...