Sample records for radiation-induced adaptive responses

  1. Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells

    SciTech Connect (OSTI)

    Jian Li

    2012-11-07T23:59:59.000Z

    A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

  2. Radiation-induced bystander effect and adaptive response in mammalian cells

    E-Print Network [OSTI]

    with cells whose nuclei have been traversed with a single alpha particle each. Pretreatment of cells-induced cancer has traditionally been estimated from cancer incidence among Japanese A-bomb survivors. These data in the absence of definitive data. Both the interna- tional commission on radiation protection (ICRP

  3. Radiation-induced gene responses

    SciTech Connect (OSTI)

    Woloschak, G.E.; Paunesku, T.; Shearin-Jones, P.; Oryhon, J.

    1996-12-31T23:59:59.000Z

    In the process of identifying genes that are differentially regulated in cells exposed to ultraviolet radiation (UV), we identified a transcript that was repressed following the exposure of cells to a combination of UV and salicylate, a known inhibitor of NF-kappaB. Sequencing this band determined that it has identify to lactate dehydrogenase, and Northern blots confirmed the initial expression pattern. Analysis of the sequence of the LDH 5` region established the presence of NF-kappaB, Sp1, and two Ap-2 elements; two partial AP- 1; one partial RE, and two halves of E-UV elements were also found. Electromobility shift assays were then performed for the AP-1, NF- kappaB, and E-UV elements. These experiments revealed that binding to NF-kappaB was induced by UV but repressed with salicylic acid; UV did not affect AP-1 binding, but salicylic acid inhibited it alone or following UV exposure; and E-UV binding was repressed by UV, and salicylic acid had little effect. Since the binding of no single element correlated with the expression pattern of LDH, it is likely that multiple elements govern UV/salicylate-mediated expression.

  4. adaptive survival responses: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    changing environment using sleep. We also quantified 15 Scaling adaptation: climate change response and Geosciences Websites Summary: , and the barriers to adaptation are...

  5. Time dependent annealing of radiation - induced leakage currents in MOS devices

    SciTech Connect (OSTI)

    Terrell, J.M. (Booz Allen and Hamilton, Inc. Bethesda, MD (US)); Olkham, T.R.; Lelis, A.J.; Benedetto, J.M. (Harry Diamond Labs., Adelphi, MD (US))

    1989-12-01T23:59:59.000Z

    Results are presented showing the radiation response of several unhardened commercial 1.25-{mu}m bulk CMOS processes using LOCOS isolation technology. In all cases studied radiation-induced failure is caused by effects in the field oxide, and the radiation-induced {delta}V{sub T} in the channel region is usually small at the failure dose. Time dependent leakage current data for the field oxides are presented and discussed.

  6. Radiation-Induced Reduction of Ceria in Single and Polycrystalline...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Radiation-Induced Reduction of Ceria in Single and Polycrystalline Thin Films. Radiation-Induced Reduction of Ceria in Single and Polycrystalline Thin Films. Abstract: Ceria (CeO2)...

  7. Radiation-induced lung injury

    SciTech Connect (OSTI)

    Rosiello, R.A.; Merrill, W.W. (Yale Univ. Medical Center, New Haven, CT (USA))

    1990-03-01T23:59:59.000Z

    The use of radiation therapy is limited by the occurrence of the potentially fatal clinical syndromes of radiation pneumonitis and fibrosis. Radiation pneumonitis usually becomes clinically apparent from 2 to 6 months after completion of radiation therapy. It is characterized by fever, cough, dyspnea, and alveolar infiltrates on chest roentgenogram and may be difficult to differentiate from infection or recurrent malignancy. The pathogenesis is uncertain, but appears to involve both direct lung tissue toxicity and an inflammatory response. The syndrome may resolve spontaneously or may progress to respiratory failure. Corticosteroids may be effective therapy if started early in the course of the disease. The time course for the development of radiation fibrosis is later than that for radiation pneumonitis. It is usually present by 1 year following irradiation, but may not become clinically apparent until 2 years after radiation therapy. It is characterized by the insidious onset of dyspnea on exertion. It most often is mild, but can progress to chronic respiratory failure. There is no known successful treatment for this condition. 51 references.

  8. Repression of ATR pathway by miR-185 enhances radiation-induced apoptosis and proliferation

    E-Print Network [OSTI]

    Cai, Long

    of miR-34a expression may be responsible for important protective mechanisms counteracting radiationOPEN Repression of ATR pathway by miR-185 enhances radiation-induced apoptosis and proliferation of a human microRNA (miRNA), hsa-miR-185, is downregulated in response to ionizing radiation. Elevation of mi

  9. Stress Response & Adaptation: A New Molecular Toolkit

    E-Print Network [OSTI]

    Storey, Kenneth B.

    · Covalent attachment of: Antibodies, Oligonucleotides · Capture of proteins, peptides, coding and non pathways that are responsible for responding to &/or repairing cellular damage. E.g. antioxidant enzymes

  10. aminoguanidine alleviates radiation-induced: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    sputtering. In this paper we study several aspects of debris and radiation-induced damage to candidate EUVL source collector optics materials. The first study concerns the use...

  11. Distributed Demand Response and User Adaptation in Smart Grids

    E-Print Network [OSTI]

    Fan, Zhong

    2010-01-01T23:59:59.000Z

    This paper proposes a distributed framework for demand response and user adaptation in smart grid networks. In particular, we borrow the concept of congestion pricing in Internet traffic control and show that pricing information is very useful to regulate user demand and hence balance network load. User preference is modeled as a willingness to pay parameter which can be seen as an indicator of differential quality of service. Both analysis and simulation results are presented to demonstrate the dynamics and convergence behavior of the algorithm.

  12. Radiation induced strand breakage analyzed by tunel technique 

    E-Print Network [OSTI]

    Reynolds, Marissa Dawn

    2003-01-01T23:59:59.000Z

    The objective of this research is to fully characterize the effectiveness and limits of using the terminal deoxynucleotidyl transferase mediated biotin-dUTP nick end labeling (TUNEL) technique for analysis of radiation induced strand breakage...

  13. Radiation induced by relativistic beams passing over a diffraction...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    August 2000 FEL 2000 1 Radiation Induced by Relativistic Beams Passing Over a Diffraction Grating J.H. Brownell, J. Walsh, J. Swartz, S. Trotz Dept. of Physics and Astronomy,...

  14. Radiation induced strand breakage analyzed by tunel technique

    E-Print Network [OSTI]

    Reynolds, Marissa Dawn

    2003-01-01T23:59:59.000Z

    The objective of this research is to fully characterize the effectiveness and limits of using the terminal deoxynucleotidyl transferase mediated biotin-dUTP nick end labeling (TUNEL) technique for analysis of radiation induced strand breakage...

  15. adaptive responses genomic: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 Biochemical Adaptation 169 From: Integrative Physiology in the Proteomics and Post-Genomics Age Biology and Medicine Websites Summary: Biochemical Adaptation 169 169 From:...

  16. Differences in synchrotron radiation induced gas desorption from stainless steel and aluminium alloy

    E-Print Network [OSTI]

    Andritschky, M; Mathewson, A G; Souchet, R; Strubin, Pierre M; Trickett, B A

    1990-01-01T23:59:59.000Z

    Differences in synchrotron radiation induced gas desorption from stainless steel and aluminium alloy

  17. Modeling radiation-induced mixing at interfaces between low solubility metals

    E-Print Network [OSTI]

    Zhang, Liang, Ph. D. Massachusetts Institute of Technology

    2014-01-01T23:59:59.000Z

    This thesis studies radiation-induced mixing at interfaces between low solubility metals using molecular dynamics (MD) computer simulations. It provides original contributions on the fundamental mechanisms of radiation-induced ...

  18. Adaptive Evolution of a Stress Response Protein Tom J. Little1

    E-Print Network [OSTI]

    Obbard, Darren

    Stress responses classically involve heat shock proteins or molecular chaperones that maintain proteinAdaptive Evolution of a Stress Response Protein Tom J. Little1 *, Lenny Nelson2 , Ted Hupp2 1 of the mammalian stress response gene SEP53, a member of the epidermal differentiation complex fused-gene family

  19. Flavin-Induced Oligomerization in Escherichia coli Adaptive Response Protein AidB

    E-Print Network [OSTI]

    Drennan, Catherine L.

    The process known as “adaptive response” allows Escherichia coli to respond to small doses of DNA-methylating agents by upregulating the expression of four proteins. While the role of three of these proteins in mitigating ...

  20. In vivo imaging of C. elegans ASH neurons: cellular response and adaptation to chemical repellents

    E-Print Network [OSTI]

    Schafer, William R.

    Erratum In vivo imaging of C. elegans ASH neurons: cellular response and adaptation to chemical neurons highlighted. From the ASH cell body, the dendrite runs anteriorly until the tip of the head ending

  1. adaptive immune response: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    vivo imaging of immune cell dynamics in skin in response to zinc-oxide nanoparticle exposure Boppart, Stephen 205 Transcriptomic Analysis of Host Immune and Cell Death...

  2. adaptive immune responses: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    vivo imaging of immune cell dynamics in skin in response to zinc-oxide nanoparticle exposure Boppart, Stephen 205 Transcriptomic Analysis of Host Immune and Cell Death...

  3. Transient radiation-induced absorption in laser materials

    SciTech Connect (OSTI)

    Brannon, P.J.

    1994-12-31T23:59:59.000Z

    Transient radiation-induced absorption losses in laser materials have been measured using a pulsed nuclear reactor. Reactor pulse widths of 70 to 90 {mu}s and absorbed doses of 1 to 7.5 krad have been used. Transmission recovery times and peak absorption coefficients are given. Materials tested include LiNbO{sub 3}, GSGG, silica substrates, and filter glasses used in the laser cavity. The filter glasses are tested at discrete wavelengths in the range 440--750 nm. Lithium niobate , MgO doped LiNbO{sub 3}, GSGG, and the silica substrates are tested at 1061 nm.

  4. Measurements of prompt radiation induced conductivity in Teflon (PTFE).

    SciTech Connect (OSTI)

    Hartman, E. Frederick; Zarick, Thomas Andrew; Sheridan, Timothy J.; Preston, E. [ITT Exelis Mission Systems, Colorado Springs, CO

    2013-05-01T23:59:59.000Z

    We performed measurements of the prompt radiation induced conductivity (RIC) in thin samples of Teflon (PTFE) at the Little Mountain Medusa LINAC facility in Ogden, UT. Three mil (76.2 microns) samples were irradiated with a 0.5 %CE%BCs pulse of 20 MeV electrons, yielding dose rates of 1E9 to 1E11 rad/s. We applied variable potentials up to 2 kV across the samples and measured the prompt conduction current. Details of the experimental apparatus and analysis are reported in this report on prompt RIC in Teflon.

  5. Between adaptation and resistance : labor responses to globalization in France

    E-Print Network [OSTI]

    Ancelovici, Marcos, 1971-

    2008-01-01T23:59:59.000Z

    This dissertation aims at accounting for labor responses to globalization in France. It addresses this issue through a comparative study of two labor organizations-the French Democratic Labor Confederation (CFDT) and the ...

  6. Nature of Radiation-Induced Defects in Quartz

    E-Print Network [OSTI]

    Bu Wang; Yingtian Yu; Isabella Pignatelli; Gaurav N. Sant; Mathieu Bauchy

    2015-04-10T23:59:59.000Z

    Although quartz ($\\rm \\alpha$-form) is a mineral used in numerous applications wherein radiation exposure is an issue, the nature of the atomistic defects formed during radiation-induced damage have not been fully clarified. Especially, the extent of oxygen vacancy formation is still debated, which is an issue of primary importance as optical techniques based on charged oxygen vacancies have been utilized to assess the level of radiation damage in quartz. In this paper, molecular dynamics (MD) simulations are applied to study the effects of ballistic impacts on the atomic network of quartz. We show that the defects that are formed mainly consist of over-coordinated Si and O, as well as Si--O connectivity defects, e.g., small Si--O rings and edge-sharing Si tetrahedra. Oxygen vacancies, on the contrary, are found in relatively low abundance, suggesting that characterizations based on $E^{\\prime}$ centers do not adequately capture radiation-induced structural damage in quartz. Finally, we evaluate the dependence on the incident energy, of the amount of each type of the point defects formed, and quantify unambiguously the threshold displacement energies for both O and Si atoms. These results provide a comprehensive basis to assess the nature and extent of radiation damage in quartz.

  7. Radiative acceleration and transient, radiation-induced electric fields

    E-Print Network [OSTI]

    L. Zampieri; R. Turolla; L. Foschini; A. Treves

    2003-04-14T23:59:59.000Z

    The radiative acceleration of particles and the electrostatic potential fields that arise in low density plasmas hit by radiation produced by a transient, compact source are investigated. We calculate the dynamical evolution and asymptotic energy of the charged particles accelerated by the photons and the radiation-induced electric double layer in the full relativistic, Klein-Nishina regime. For fluxes in excess of $10^{27}$ ${\\rm erg} {\\rm cm}^{-2} {\\rm s}^{-1}$, the radiative force on a diluted plasma ($n\\la 10^{11}$ cm$^{-3}$) is so strong that electrons are accelerated rapidly to relativistic speeds while ions lag behind owing to their larger inertia. The ions are later effectively accelerated by the strong radiation-induced double layer electric field up to Lorentz factors $\\approx 100$, attainable in the case of negligible Compton drag. The asymptotic energies achieved by both ions and electrons are larger by a factor 2--4 with respect to what one could naively expect assuming that the electron-ion assembly is a rigidly coupled system. The regime we investigate may be relevant within the framework of giant flares from soft gamma-repeaters.

  8. Nature of Radiation-Induced Defects in Quartz

    E-Print Network [OSTI]

    Wang, Bu; Pignatelli, Isabella; Sant, Gaurav N; Bauchy, Mathieu

    2015-01-01T23:59:59.000Z

    Although quartz ($\\rm \\alpha$-form) is a mineral used in numerous applications wherein radiation exposure is an issue, the nature of the atomistic defects formed during radiation-induced damage have not been fully clarified. Especially, the extent of oxygen vacancy formation is still debated, which is an issue of primary importance as optical techniques based on charged oxygen vacancies have been utilized to assess the level of radiation damage in quartz. In this paper, molecular dynamics (MD) simulations are applied to study the effects of ballistic impacts on the atomic network of quartz. We show that the defects that are formed mainly consist of over-coordinated Si and O, as well as Si--O connectivity defects, e.g., small Si--O rings and edge-sharing Si tetrahedra. Oxygen vacancies, on the contrary, are found in relatively low abundance, suggesting that characterizations based on $E^{\\prime}$ centers do not adequately capture radiation-induced structural damage in quartz. Finally, we evaluate the dependenc...

  9. Global transcriptional, physiological and metabolite analyses of Desulfovibrio vulgaris Hildenborough responses to salt adaptation

    SciTech Connect (OSTI)

    He, Z.; Zhou, A.; Baidoo, E.; He, Q.; Joachimiak, M. P.; Benke, P.; Phan, R.; Mukhopadhyay, A.; Hemme, C.L.; Huang, K.; Alm, E.J.; Fields, M.W.; Wall, J.; Stahl, D.; Hazen, T.C.; Keasling, J.D.; Arkin, A.P.; Zhou, J.

    2009-12-01T23:59:59.000Z

    The response of Desulfovibrio vulgaris Hildenborough to salt adaptation (long-term NaCl exposure) was examined by physiological, global transcriptional, and metabolite analyses. The growth of D. vulgaris was inhibited by high levels of NaCl, and the growth inhibition could be relieved by the addition of exogenous amino acids (e.g., glutamate, alanine, tryptophan) or yeast extract. Salt adaptation induced the expression of genes involved in amino acid biosynthesis and transport, electron transfer, hydrogen oxidation, and general stress responses (e.g., heat shock proteins, phage shock proteins, and oxidative stress response proteins). Genes involved in carbon metabolism, cell motility, and phage structures were repressed. Comparison of transcriptomic profiles of D. vulgaris responses to salt adaptation with those of salt shock (short-term NaCl exposure) showed some similarity as well as a significant difference. Metabolite assays showed that glutamate and alanine were accumulated under salt adaptation, suggesting that they may be used as osmoprotectants in D. vulgaris. A conceptual model is proposed to link the observed results to currently available knowledge for further understanding the mechanisms of D. vulgaris adaptation to elevated NaCl.

  10. Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization

    E-Print Network [OSTI]

    Costes, Sylvain V

    2010-01-01T23:59:59.000Z

    to ionizing radiation are nuclear marks of permanentto ionizing radiation are nuclear marks of permanentvisible nuclear domains referred to as radiation-induced

  11. Radiation-induced solitary waves in hot plasmas of accretion disks

    E-Print Network [OSTI]

    Fedor V. Prigara

    2005-07-08T23:59:59.000Z

    It is shown that the existence of radiation-induced solitary waves in hot plasmas of accretion disks depends on the radial temperature profile.

  12. attenuates ionizing radiation-induced: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Article Influence of XRCC1 Genetic Polymorphisms on Ionizing Radiation-Induced DNA Damage and Repair CiteSeer Summary: License, which permits unrestricted use, distribution,...

  13. ameliorates radiation-induced lung: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    sputtering. In this paper we study several aspects of debris and radiation-induced damage to candidate EUVL source collector optics materials. The first study concerns the use...

  14. alleviates radiation-induced small-bowel: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    sputtering. In this paper we study several aspects of debris and radiation-induced damage to candidate EUVL source collector optics materials. The first study concerns the use...

  15. Regular PaperJ. Radiat. Res., 51, 657664 (2010) Adaptive Response in Zebrafish Embryos Induced Using

    E-Print Network [OSTI]

    Yu, K.N.

    2010-01-01T23:59:59.000Z

    in the zebrafish embryos in vivo. INTRODUCTION For radiation protection purposes, prediction of risk from this model is commonly adopted for radiation protection purposes, there is a considerable amount of evidenceRegular PaperJ. Radiat. Res., 51, 657­664 (2010) Adaptive Response in Zebrafish Embryos Induced

  16. Irradiated Esophageal Cells are Protected from Radiation-Induced Recombination by MnSOD Gene Therapy

    E-Print Network [OSTI]

    Engelward, Bevin

    Irradiated Esophageal Cells are Protected from Radiation-Induced Recombination by MnSOD Gene. Irradiated Esophageal Cells are Protected from Radiation- Induced Recombination by MnSOD Gene Therapy. Radiat,a Bevin Engelward,b Michael Epperlya and Joel S. Greenbergera,1 a Departments of Radiation Oncology

  17. Mechanism of radiation-induced bystander effect: Role of the cyclooxygenase-2 signaling pathway

    E-Print Network [OSTI]

    Brenner, David Jonathan

    impact on our thinking as well as immediate application in radiation protection. RadiationMechanism of radiation-induced bystander effect: Role of the cyclooxygenase-2 signaling pathway 25, 2005 (received for review June 30, 2005) The radiation-induced bystander effect is defined

  18. Effects of exogenous carbon monoxide on radiation-induced bystander effect in zebrafish embryos in vivo

    E-Print Network [OSTI]

    Yu, K.N.

    -no-threshed (LNT) model widely accepted for radiation protection saying that biological effects caused by ionizingEffects of exogenous carbon monoxide on radiation-induced bystander effect in zebrafish embryos) on the radiation induced bystander effect (RIBE) in vivo between embryos of the zebrafish was studied. RIBE

  19. Mini-review Radiation-induced bystander effect: Early process and rapid assessment

    E-Print Network [OSTI]

    Yu, K.N.

    by the radiation protection agencies. How- ever, this dogma has been challenged by scientific findings since 1990sMini-review Radiation-induced bystander effect: Early process and rapid assessment Hongzhi Wang September 2013 Accepted 26 September 2013 Keywords: Radiation-induced bystander effect Rapid assessment

  20. Why occupancy-responsive adaptive thermostats do not always save -and the limits for when they should

    E-Print Network [OSTI]

    California at Davis, University of

    Why occupancy-responsive adaptive thermostats do not always save - and the limits for when thermostats do not guarantee energy savings. As a result, EPA ended EnergyStar certification of programmable, and adaptive control schemes have shown significant annual HVAC savings on the order of 10-20%. However

  1. Dosimetric Analysis of Radiation-induced Gastric Bleeding

    SciTech Connect (OSTI)

    Feng, Mary, E-mail: maryfeng@umich.edu [Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan (United States); Normolle, Daniel [Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania (United States)] [Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania (United States); Pan, Charlie C. [Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan (United States); Dawson, Laura A. [Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario (Canada)] [Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario (Canada); Amarnath, Sudha [Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan (United States); Ensminger, William D. [Department of Internal Medicine, Division of Hematology Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan (United States)] [Department of Internal Medicine, Division of Hematology Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan (United States); Lawrence, Theodore S.; Ten Haken, Randall K. [Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan (United States)

    2012-09-01T23:59:59.000Z

    Purpose: Radiation-induced gastric bleeding has been poorly understood. In this study, we described dosimetric predictors for gastric bleeding after fractionated radiation therapy. Methods and Materials: The records of 139 sequential patients treated with 3-dimensional conformal radiation therapy (3D-CRT) for intrahepatic malignancies were reviewed. Median follow-up was 7.4 months. The parameters of a Lyman normal tissue complication probability (NTCP) model for the occurrence of {>=}grade 3 gastric bleed, adjusted for cirrhosis, were fitted to the data. The principle of maximum likelihood was used to estimate parameters for NTCP models. Results: Sixteen of 116 evaluable patients (14%) developed gastric bleeds at a median time of 4.0 months (mean, 6.5 months; range, 2.1-28.3 months) following completion of RT. The median and mean maximum doses to the stomach were 61 and 63 Gy (range, 46-86 Gy), respectively, after biocorrection of each part of the 3D dose distributions to equivalent 2-Gy daily fractions. The Lyman NTCP model with parameters adjusted for cirrhosis predicted gastric bleed. Best-fit Lyman NTCP model parameters were n=0.10 and m=0.21 and with TD{sub 50} (normal) = 56 Gy and TD{sub 50} (cirrhosis) = 22 Gy. The low n value is consistent with the importance of maximum dose; a lower TD{sub 50} value for the cirrhosis patients points out their greater sensitivity. Conclusions: This study demonstrates that the Lyman NTCP model has utility for predicting gastric bleeding and that the presence of cirrhosis greatly increases this risk. These findings should facilitate the design of future clinical trials involving high-dose upper abdominal radiation.

  2. affecting radiation-induced neurological: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    therapeutic effects of IR. Alternate p53 Su, Tin Tin 40 Debris and Radiation-Induced Damage Effects on EUV Nanolithography Source Collector Mirror Optics Performance CiteSeer...

  3. attenuates murine radiation-induced: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2-3. Rupert A. C. Croft; Gabriel Altay 2007-09-14 52 Debris and Radiation-Induced Damage Effects on EUV Nanolithography Source Collector Mirror Optics Performance CiteSeer...

  4. Scientists in a Changed Institutional Environment: Subjective Adaptation and Social Responsibility Norms in Russia

    SciTech Connect (OSTI)

    Gerber, T P; Ball, D Y

    2008-06-05T23:59:59.000Z

    How do scientists react when the institutional setting in which they conduct their work changes radically? How do long-standing norms regarding the social responsibility of scientists fare? What factors influence whether scientists embrace or reject the new institutions and norms? We examine these questions using data from a unique survey of 602 scientists in Russia, whose science system experienced a sustained crisis and sweeping changes in science institutions following the collapse of the Soviet Union. We develop measures of how respondents view financing based on grants and other institutional changes in the Russian science system, as well as measures of two norms regarding scientists social responsibility. We find that the majority of scientists have adapted, in the sense that they hold positive views of the new institutions, but a diversity of orientations remains. Social responsibility norms are common among Russian scientists, but far from universal. The main correlates of adaptation are age and current success at negotiating the new institutions, though prospective success, work context, and ethnicity have some of the hypothesized associations. As for social responsibility norms, the main source of variation is age: younger scientists are more likely to embrace individualistic rather than socially-oriented norms.

  5. Radiation-induced esophageal injury: A spectrum from esophagitis to cancer

    SciTech Connect (OSTI)

    Vanagunas, A.; Jacob, P.; Olinger, E. (Northwestern Univ. Medical School, Chicago, IL (USA))

    1990-07-01T23:59:59.000Z

    Radiation esophagitis is a common but frequently unrecognized complication of therapeutic radiation to the neck, chest, or mediastinum. The spectrum of injury ranges from acute self-limited esophagitis to life-threatening esophageal perforation. Complications such as stricture or primary esophageal cancer may occur many years after irradiation, and their linkage to radiation may not be considered. Five cases of radiation-induced injury are described, and the spectrum of radiation-induced esophageal injury is reviewed.

  6. Cyclic 3',5'-AMP Relay i n Dictyostelium discoideum V. Adaptation of the CAMP Signaling Response

    E-Print Network [OSTI]

    Devreotes, Peter

    Cyclic 3',5'-AMP Relay i n Dictyostelium discoideum V. Adaptation of the CAMP Signaling Response, and then immediately given test stimuli of 10-8 M to 2.5 X 10-7 M cAMP. The response to a given test stimulus to the concentration of the test stimulus . The responses to test stimuli of 10-8, 5 X 10-8, 10-7, or 2.5 X 10-7 M c

  7. LDRD final report on adaptive-responsive nanostructures for sensing applications.

    SciTech Connect (OSTI)

    Shelnutt, John Allen; van Swol, Frank B.; Wang, Zhongchun; Medforth, Craig J.

    2005-11-01T23:59:59.000Z

    Functional organic nanostructures such as well-formed tubes or fibers that can easily be fabricated into electronic and photonic devices are needed in many applications. Especially desirable from a national security standpoint are nanostructures that have enhanced sensitivity for the detection of chemicals and biological (CB) agents and other environmental stimuli. We recently discovered the first class of highly responsive and adaptive porphyrin-based nanostructures that may satisfy these requirements. These novel porphyrin nanostructures, which are formed by ionic self-assembly of two oppositely charged porphyrins, may function as conductors, semiconductors, or photoconductors, and they have additional properties that make them suitable for device fabrication (e.g., as ultrasensitive colorimetric CB microsensors). Preliminary studies with porphyrin nanotubes have shown that these nanostructures have novel optical and electronic properties, including strong resonant light scattering, quenched fluorescence, and electrical conductivity. In addition, they are photochemically active and capable of light-harvesting and photosynthesis; they may also have nonlinear optical properties. Remarkably, the nanotubes and potentially other porphyrin nanostructure are mechanically responsive and adaptive (e.g., the rigidity of the micrometers-long nanotubes is altered by light, ultrasound, or chemicals) and they self-heal upon removal the environmental stimulus. Given the tremendous degree of structural variation possible in the porphyrin subunits, additional types of nanostructures and greater control over their morphology can be anticipated. Molecular modification also provides a means of controlling their electronic, photonic, and other functional properties. In this work, we have greatly broadened the range of ionic porphyrin nanostructures that can be made, and determined the optical and responsivity properties of the nanotubes and other porphyrin nanostructures. We have also explored means for controlling their morphology, size, and placement on surfaces. The research proposed will lay the groundwork for the use of these remarkable porphyrin nanostructures in micro- and nanoscale devices, by providing a more detailed understanding of their molecular structure and the factors that control their structural, photophysical, and chemical properties.

  8. Abstract Due to reduction in device feature size and supply voltage, the sensitivity to radiation induced transient faults of

    E-Print Network [OSTI]

    Marculescu, Diana

    , the protection from radiation induced transient faults has become as important as other product characteristics to radiation induced transient faults of digital systems increases dramatically. In this paper, we present two targeting radiation hardening leading up to 80% SER reduction when applied to a subset of ISCAS'89

  9. Debris and Radiation-Induced Damage Effects on EUV Nanolithography Source Collector Mirror Optics Performance

    E-Print Network [OSTI]

    Harilal, S. S.

    Debris and Radiation-Induced Damage Effects on EUV Nanolithography Source Collector Mirror Optics, Argonne, Illinois ABSTRACT Exposure of collector mirrors facing the hot, dense pinch plasma in plasma region of the lamp are known to induce serious damage to nearby collector mirrors. Candidate collector

  10. EXTRAPOLATING RADIATION-INDUCED CANCER RISKS FROM LOW DOSES TO VERY LOW DOSES

    E-Print Network [OSTI]

    Brenner, David Jonathan

    risk; National Council on Radiation Protection and Measurements INTRODUCTION THERE IS considerablePaper EXTRAPOLATING RADIATION-INDUCED CANCER RISKS FROM LOW DOSES TO VERY LOW DOSES David J. Brenner* Abstract--There is strong evidence that ionizing radiation increases cancer risks at high doses

  11. A Prospective Cohort Study on Radiation-induced Hypothyroidism: Development of an NTCP Model

    SciTech Connect (OSTI)

    Boomsma, Marjolein J.; Bijl, Hendrik P.; Christianen, Miranda E.M.C.; Beetz, Ivo; Chouvalova, Olga; Steenbakkers, Roel J.H.M. [Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Laan, Bernard F.A.M. van der [Department of Otorhinolaryngology/Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Wolffenbuttel, Bruce H.R. [Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)] [Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Oosting, Sjoukje F. [Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)] [Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Schilstra, Cornelis [Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)] [Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Langendijk, Johannes A., E-mail: j.a.langendijk@umcg.nl [Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)

    2012-11-01T23:59:59.000Z

    Purpose: To establish a multivariate normal tissue complication probability (NTCP) model for radiation-induced hypothyroidism. Methods and Materials: The thyroid-stimulating hormone (TSH) level of 105 patients treated with (chemo-) radiation therapy for head-and-neck cancer was prospectively measured during a median follow-up of 2.5 years. Hypothyroidism was defined as elevated serum TSH with decreased or normal free thyroxin (T4). A multivariate logistic regression model with bootstrapping was used to determine the most important prognostic variables for radiation-induced hypothyroidism. Results: Thirty-five patients (33%) developed primary hypothyroidism within 2 years after radiation therapy. An NTCP model based on 2 variables, including the mean thyroid gland dose and the thyroid gland volume, was most predictive for radiation-induced hypothyroidism. NTCP values increased with higher mean thyroid gland dose (odds ratio [OR]: 1.064/Gy) and decreased with higher thyroid gland volume (OR: 0.826/cm{sup 3}). Model performance was good with an area under the curve (AUC) of 0.85. Conclusions: This is the first prospective study resulting in an NTCP model for radiation-induced hypothyroidism. The probability of hypothyroidism rises with increasing dose to the thyroid gland, whereas it reduces with increasing thyroid gland volume.

  12. Clinical Outcomes of 174 Nasopharyngeal Carcinoma Patients With Radiation-Induced Temporal Lobe Necrosis

    SciTech Connect (OSTI)

    Lam, Tai-Chung, E-mail: lamtaichung@gmail.com [Department of Clinical Oncology, Tuen Mun Hospital (Hong Kong); Wong, Frank C.S. [Department of Clinical Oncology, Tuen Mun Hospital (Hong Kong); Leung, To-Wai [Department of Clinical Oncology, Queen Mary Hospital (Hong Kong); Ng, S.H. [Department of Medicine and Geriatrics, Tuen Mun Hospital (Hong Kong); Tung, Stewart Y. [Department of Clinical Oncology, Tuen Mun Hospital (Hong Kong)

    2012-01-01T23:59:59.000Z

    Purpose: To retrospectively study the clinical outcomes of nasopharyngeal carcinoma patients with radiation-induced temporal lobe necrosis (TLN) treated with steroids, surgery, or observation only. Methods and Patients: We performed a retrospective analysis of 174 consecutive patients diagnosed with TLN between 1990 and 2008. Before 1998, symptomatic patients were treated with oral steroids, while asymptomatic patients were treated conservatively. After 1998, most symptomatic and asymptomatic patients with a large volume of necrosis were treated by intravenously pulsed-steroid therapy with a standardized protocol. We examined factors affecting grade 4 complication-free survival and overall survival. Outcomes of the three treatment groups, those receiving conservative treatment, those receiving oral steroid, and those receiving intravenous pulse steroid, were compared. Results: The mean follow-up time was 115 months. Rates of grade 4 complication-free survival at 2 years and at 5 years after diagnosis of TLN were 72.2% and 54.1%, respectively. The 2-year and 5-year overall survival rates were 57.5% and 35.4%, respectively. Multivariate analysis revealed that being symptomatic at diagnosis (relative risk [RR], 4.5; p = 0.0001), re-irradiation of the nasopharynx (NP) (RR, 1.56; p = 0.008), salvage brachytherapy to the NP (RR, 1.75; p = 0.012), and a short latency period before the diagnosis of TLN (RR, 0.96, p < 0.0001) were independent prognosticators of poor grade 4 complication-free survival. Patients with all four factors had a 100% risk of developing grade 4 complications within 5 years; whereas if no factor was present, the risk was 12.5%. Intravenous pulse steroid therapy was associated with a higher clinical response rate compared with conventional steroid therapy (p < 0.0001); however, it did not affect complication-free survival in multivariate analysis. Conclusions: TLN patients with good prognosticators could be observed without active treatment. Although treatment with intravenously pulsed steroid was associated with better clinical response than conventional steroid delivery, it did not affect the complication-free survival rate of TLN patients.

  13. Radiation-induced Genomic Instability and Radiation Sensitivity

    SciTech Connect (OSTI)

    Varnum, Susan M.; Sowa, Marianne B.; Kim, Grace J.; Morgan, William F.

    2013-01-19T23:59:59.000Z

    The obvious relationships between reactive oxygen and nitrogen species, mitochondrial dysfunction, inflammatory type responses and reactive chemokines and cytokines suggests a general stress response induced by ionizing radiation most likely leads to the non-targeted effects described after radiation exposure. We argue that true bystander effects do not occur in the radiation therapy clinic. But there is no question that effects outside the target volume do occur. These “out of field effects” are considered very low dose effects in the context of therapy. So what are the implications of non-targeted effects on radiation sensitivity? The primary goal of therapy is to eradicate the tumor. Given the genetic diversity of the human population, lifestyle and environment factors it is likely some combination of these will influence patient outcome. Non-targeted effects may contribute to a greater or lesser extent. But consider the potential situation involving a partial body exposure due to a radiation accident or radiological terrorism. Non-targeted effects suggest that the tissue at risk for demonstrating possible detrimental effects of radiation exposure might be greater than the volume actually irradiated.

  14. Radiation induces turbulence in particle-laden fluids

    SciTech Connect (OSTI)

    Zamansky, Rémi [Centre for Turbulence Research, Stanford University, Stanford, California 94305-3035 (United States); Coletti, Filippo [Mechanical Engineering, Stanford University, California 94305-3035 (United States); Massot, Marc [Centre for Turbulence Research, Stanford University, Stanford, California 94305-3035 (United States); Ecole Centrale Paris, Laboratoire EM2C - UPR CNRS 288 et Fédération de Mathématiques - FR CNRS 3487, Grande Voie des Vignes, 92295 Chatenay-Malabry Cedex (France); Mani, Ali [Centre for Turbulence Research, Stanford University, Stanford, California 94305-3035 (United States); Mechanical Engineering, Stanford University, California 94305-3035 (United States)

    2014-07-15T23:59:59.000Z

    When a transparent fluid laden with solid particles is subject to radiative heating, non-uniformities in particle distribution result in local fluid temperature fluctuations. Under the influence of gravity, buoyancy induces vortical fluid motion which can lead to strong preferential concentration, enhancing the local heating and more non-uniformities in particle distribution. By employing direct numerical simulations this study shows that the described feedback loop can create and sustain turbulence. The velocity and length scale of the resulting turbulence is not known a priori, and is set by balance between viscous forces and buoyancy effects. When the particle response time is comparable to a viscous time scale, introduced in our analysis, the system exhibits intense fluctuations of turbulent kinetic energy and strong preferential concentration of particles.

  15. Radiation-induced mechanical property changes in filled rubber

    SciTech Connect (OSTI)

    Maiti, A.; Weisgraber, T. H.; Gee, R. H.; Small, W.; Alviso, C. T.; Chinn, S. C.; Maxwell, R. S. [Lawrence Livermore National Laboratory, Livermore, CA 94550 (United States)

    2011-06-15T23:59:59.000Z

    In a recent paper we exposed a filled elastomer to controlled radiation dosages and explored changes in its cross-link density and molecular weight distribution between network junctions [A. Maiti et al., Phys. Rev. E 83, 031802 (2011)]. Here we report mechanical response measurements when the material is exposed to radiation while being under finite nonzero strain. We observe interesting hysteretic behavior and material softening representative of the Mullins effect, and materials hardening due to radiation. The net magnitude of the elastic modulus depends upon the radiation dosage, strain level, and strain-cycling history of the material. Using the framework of Tobolsky's two-stage independent network theory we develop a model that can quantitatively interpret the observed elastic modulus and its radiation and strain dependence.

  16. Flavin-Induced Oligomerization in Escherichia coli Adaptive Response Protein AidB

    SciTech Connect (OSTI)

    Hamill, Michael J.; Jost, Marco; Wong, Cintyu; Elliott, Sean J.; Drennan, Catherine L. (MIT); (BU)

    2011-11-21T23:59:59.000Z

    The process known as 'adaptive response' allows Escherichia coli to respond to small doses of DNA-methylating agents by upregulating the expression of four proteins. While the role of three of these proteins in mitigating DNA damage is well understood, the function of AidB is less clear. Although AidB is a flavoprotein, no catalytic role has been established for the bound cofactor. Here we investigate the possibility that flavin plays a structural role in the assembly of the AidB tetramer. We report the generation and biophysical characterization of deflavinated AidB and of an AidB mutant that has greatly reduced affinity for flavin adenine dinucleotide (FAD). Using fluorescence quenching and analytical ultracentrifugation, we find that apo AidB has a high affinity for FAD, as indicated by an apparent dissociation constant of 402.1 {+-} 35.1 nM, and that binding of substoichiometric amounts of FAD triggers a transition in the AidB oligomeric state. In particular, deflavinated AidB is dimeric, whereas the addition of FAD yields a tetramer. We further investigate the dimerization and tetramerization interfaces of AidB by determining a 2.8 {angstrom} resolution crystal structure in space group P3{sub 2} that contains three intact tetramers in the asymmetric unit. Taken together, our findings provide strong evidence that FAD plays a structural role in the formation of tetrameric AidB.

  17. The versatile E. coli adaptive response protein AlkB mitigates toxicity and mutagenicity of etheno-, ethano-, and methyl-modified bases in vivo

    E-Print Network [OSTI]

    Frick, Lauren Elizabeth

    2007-01-01T23:59:59.000Z

    The Escherichia coli AlkB protein is an exceptionally versatile DNA repair enzyme. Its expression is induced upon exposure to alkylating agents as part of the Ada-mediated adaptive response. This member of the ac-ketoglu ...

  18. A Systems Genetic Approach to Identify Low Dose Radiation-Induced Lymphoma Susceptibility/DOE2013FinalReport

    SciTech Connect (OSTI)

    Balmain, Allan [University of California, San Francisco; Song, Ihn Young [University of California, San Francisco

    2013-05-15T23:59:59.000Z

    The ultimate goal of this project is to identify the combinations of genetic variants that confer an individual's susceptibility to the effects of low dose (0.1 Gy) gamma-radiation, in particular with regard to tumor development. In contrast to the known effects of high dose radiation in cancer induction, the responses to low dose radiation (defined as 0.1 Gy or less) are much less well understood, and have been proposed to involve a protective anti-tumor effect in some in vivo scientific models. These conflicting results confound attempts to develop predictive models of the risk of exposure to low dose radiation, particularly when combined with the strong effects of inherited genetic variants on both radiation effects and cancer susceptibility. We have used a Â?Â?Systems Genetics approach in mice that combines genetic background analysis with responses to low and high dose radiation, in order to develop insights that will allow us to reconcile these disparate observations. Using this comprehensive approach we have analyzed normal tissue gene expression (in this case the skin and thymus), together with the changes that take place in this gene expression architecture a) in response to low or high- dose radiation and b) during tumor development. Additionally, we have demonstrated that using our expression analysis approach in our genetically heterogeneous/defined radiation-induced tumor mouse models can uniquely identify genes and pathways relevant to human T-ALL, and uncover interactions between common genetic variants of genes which may lead to tumor susceptibility.

  19. Radiation-induced complications in prostate cancer patients treated with radiotherapy

    SciTech Connect (OSTI)

    Azuddin, A. Yusof [School of Applied Physics, Faculty of Sciences and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia and Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 53000 Kuala Lumpur (Malaysia); Rahman, I. Abdul; Mohamed, F. [School of Applied Physics, Faculty of Sciences and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor (Malaysia); Siah, N. J. [Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 53000 Kuala Lumpur (Malaysia); Saadc, M. [Department of Oncology, University Malaya Medical Center, 50603 Kuala Lumpur (Malaysia); Ismail, F. [Department of Oncology and Radiotherapy, Universiti Kebangsaan Malaysia Medical Centre, 56000 Cheras, Kuala Lumpur (Malaysia)

    2014-09-03T23:59:59.000Z

    The purpose of the study is to determine the relationship between radiation-induced complications with dosimetric and radiobiological parameters for prostate cancer patients that underwent the conformal radiotherapy treatment. 17 prostate cancer patients that have been treated with conformal radiotherapy were retrospectively analysed. The dosimetric data was retrieved in the form of dose-volume histogram (DVH) from Radiotherapy Treatment Planning System. The DVH was utilised to derived Normal Tissue Complication Probability (NTCP) in radiobiological data. Follow-up data from medical records were used to grade the occurrence of acute gastrointestinal (GI) and genitourinary (GU) complications using Radiation Therapy Oncology Group (RTOG) scoring system. The chi-square test was used to determine the relationship between radiation-induced complication with dosimetric and radiobiological parameters. 8 (47%) and 7 (41%) patients were having acute GI and GU complications respectively. The acute GI complication can be associated with V60{sub rectum}, rectal mean dose and NTCP{sub rectum} with p-value of 0.016, 0.038 and 0.049 respectively. There are no significant relationships of acute GU complication with dosimetric and radiobiological variables. Further study can be done by increase the sample size and follow up duration for deeper understanding of the factors that effecting the GU and GI complication in prostate cancer radiotherapy.

  20. Risk Analysis and Adaptive Response Planning for Water Distribution Systems Contamination Emergency Management

    E-Print Network [OSTI]

    Rasekh, Amin

    2012-10-19T23:59:59.000Z

    are investigated. Pressure-driven hydraulic analysis is performed to simulate the complicated system hydraulics under pressure-deficit conditions. Performance of a novel preventive response action ? injection of food-grade dye directly into drinking water...

  1. Radiation-Induced Segregation and Phase Stability in Candidate Alloys for the Advanced Burner Reactor

    SciTech Connect (OSTI)

    Gary S. Was; Brian D. Wirth

    2011-05-29T23:59:59.000Z

    Major accomplishments of this project were the following: 1) Radiation induced depletion of Cr occurs in alloy D9, in agreement with that observed in austenitic alloys. 2) In F-M alloys, Cr enriches at PAG grain boundaries at low dose (<7 dpa) and at intermediate temperature (400°C) and the magnitude of the enrichment decreases with temperature. 3) Cr enrichment decreases with dose, remaining enriched in alloy T91 up to 10 dpa, but changing to depletion above 3 dpa in HT9 and HCM12A. 4) Cr has a higher diffusivity than Fe by a vacancy mechanism and the corresponding atomic flux of Cr is larger than Fe in the opposite direction to the vacancy flux. 5) Cr concentration at grain boundaries decreases as a result of vacancy transport during electron or proton irradiation, consistent with Inverse Kirkendall models. 6) Inclusion of other point defect sinks into the KLMC simulation of vacancy-mediated diffusion only influences the results in the low temperature, recombination dominated regime, but does not change the conclusion that Cr depletes as a result of vacancy transport to the sink. 7) Cr segregation behavior is independent of Frenkel pair versus cascade production, as simulated for electron versus proton irradiation conditions, for the temperatures investigated. 8) The amount of Cr depletion at a simulated planar boundary with vacancy-mediated diffusion reaches an apparent saturation value by about 1 dpa, with the precise saturation concentration dependent on the ratio of Cr to Fe diffusivity. 9) Cr diffuses faster than Fe by an interstitial transport mechanism, and the corresponding atomic flux of Cr is much larger than Fe in the same direction as the interstitial flux. 10) Observed experimental and computational results show that the radiation induced segregation behavior of Cr is consistent with an Inverse Kirkendall mechanism.

  2. The Role of Platelet Factor 4 in Radiation-Induced Thrombocytopenia

    SciTech Connect (OSTI)

    Lambert, Michele P., E-mail: lambertm@email.chop.edu [Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA (United States); Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA (United States); Xiao Liqing; Nguyen, Yvonne [Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA (United States); Kowalska, M. Anna [Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA (United States); Center for Medical Biology, Polish Academy of Science, Lodz (Poland); Poncz, Mortimer [Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA (United States); Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA (United States)

    2011-08-01T23:59:59.000Z

    Purpose: Factors affecting the severity of radiation-induced thrombocytopenia (RIT) are not well described. We address whether platelet factor 4 (PF4; a negative paracrine for megakaryopoiesis) affects platelet recovery postradiation. Methods and Materials: Using conditioned media from irradiated bone marrow (BM) cells from transgenic mice overexpressing human (h) PF4 (hPF4+), megakaryocyte colony formation was assessed in the presence of this conditioned media and PF4 blocking agents. In a model of radiation-induced thrombocytopenia, irradiated mice with varying PF4 expression levels were treated with anti-hPF4 and/or thrombopoietin (TPO), and platelet count recovery and survival were examined. Results: Conditioned media from irradiated BM from hPF4+ mice inhibited megakaryocyte colony formation, suggesting that PF4 is a negative paracrine released in RIT. Blocking with an anti-hPF4 antibody restored colony formation of BM grown in the presence of hPF4+ irradiated media, as did antibodies that block the megakaryocyte receptor for PF4, low-density lipoprotein receptor-related protein 1 (LRP1). Irradiated PF4 knockout mice had higher nadir platelet counts than irradiated hPF4+/knockout litter mates (651 vs. 328 x 106/mcL, p = 0.02) and recovered earlier (15 days vs. 22 days, respectively, p <0.02). When irradiated hPF4+ mice were treated with anti-hPF4 antibody and/or TPO, they showed less severe thrombocytopenia than untreated mice, with improved survival and time to platelet recovery, but no additive effect was seen. Conclusions: Our studies show that in RIT, damaged megakaryocytes release PF4 locally, inhibiting platelet recovery. Blocking PF4 enhances recovery while released PF4 from megakaryocytes limits TPO efficacy, potentially because of increased release of PF4 stimulated by TPO. The clinical value of blocking this negative paracrine pathway post-RIT remains to be determined.

  3. Adaptive phenotypic differentiation of courtship in response to recent anthropogenic disturbance

    E-Print Network [OSTI]

    Candolin, Ulrika

    differentiated in response to spatial variation in human-induced eutrophication? Populations: Parallel pairs-induced eutrophication during the last decades. Methods: Males from mildly and severely eutrophied habitats were allowed variation in human-induced eutrophication. The differentiation should improve individual fitness. Keywords

  4. Normal Tissue Complication Probability Modeling of Radiation-Induced Hypothyroidism After Head-and-Neck Radiation Therapy

    SciTech Connect (OSTI)

    Bakhshandeh, Mohsen [Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran (Iran, Islamic Republic of)] [Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran (Iran, Islamic Republic of); Hashemi, Bijan, E-mail: bhashemi@modares.ac.ir [Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran (Iran, Islamic Republic of)] [Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran (Iran, Islamic Republic of); Mahdavi, Seied Rabi Mehdi [Department of Medical Physics, Faculty of Medical Sciences, Tehran University of Medical Sciences, Tehran (Iran, Islamic Republic of)] [Department of Medical Physics, Faculty of Medical Sciences, Tehran University of Medical Sciences, Tehran (Iran, Islamic Republic of); Nikoofar, Alireza; Vasheghani, Maryam [Department of Radiation Oncology, Hafte-Tir Hospital, Tehran University of Medical Sciences, Tehran (Iran, Islamic Republic of)] [Department of Radiation Oncology, Hafte-Tir Hospital, Tehran University of Medical Sciences, Tehran (Iran, Islamic Republic of); Kazemnejad, Anoshirvan [Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran (Iran, Islamic Republic of)] [Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran (Iran, Islamic Republic of)

    2013-02-01T23:59:59.000Z

    Purpose: To determine the dose-response relationship of the thyroid for radiation-induced hypothyroidism in head-and-neck radiation therapy, according to 6 normal tissue complication probability models, and to find the best-fit parameters of the models. Methods and Materials: Sixty-five patients treated with primary or postoperative radiation therapy for various cancers in the head-and-neck region were prospectively evaluated. Patient serum samples (tri-iodothyronine, thyroxine, thyroid-stimulating hormone [TSH], free tri-iodothyronine, and free thyroxine) were measured before and at regular time intervals until 1 year after the completion of radiation therapy. Dose-volume histograms (DVHs) of the patients' thyroid gland were derived from their computed tomography (CT)-based treatment planning data. Hypothyroidism was defined as increased TSH (subclinical hypothyroidism) or increased TSH in combination with decreased free thyroxine and thyroxine (clinical hypothyroidism). Thyroid DVHs were converted to 2 Gy/fraction equivalent doses using the linear-quadratic formula with {alpha}/{beta} = 3 Gy. The evaluated models included the following: Lyman with the DVH reduced to the equivalent uniform dose (EUD), known as LEUD; Logit-EUD; mean dose; relative seriality; individual critical volume; and population critical volume models. The parameters of the models were obtained by fitting the patients' data using a maximum likelihood analysis method. The goodness of fit of the models was determined by the 2-sample Kolmogorov-Smirnov test. Ranking of the models was made according to Akaike's information criterion. Results: Twenty-nine patients (44.6%) experienced hypothyroidism. None of the models was rejected according to the evaluation of the goodness of fit. The mean dose model was ranked as the best model on the basis of its Akaike's information criterion value. The D{sub 50} estimated from the models was approximately 44 Gy. Conclusions: The implemented normal tissue complication probability models showed a parallel architecture for the thyroid. The mean dose model can be used as the best model to describe the dose-response relationship for hypothyroidism complication.

  5. Removal of N-Alkyl Modifications from N[superscript 2]-Alkylguanine and N[superscript 4]-Alkylcytosine in DNA by the Adaptive Response Protein AlkB

    E-Print Network [OSTI]

    Li, Deyu

    The AlkB enzyme is an Fe(II)- and ?-ketoglutarate-dependent dioxygenase that repairs DNA alkyl lesions by a direct reversal of damage mechanism as part of the adaptive response in E. coli. The reported substrate scope of ...

  6. Radiation-Induced Decomposition of U(VI) Phase to Nanocrystals of UO2

    SciTech Connect (OSTI)

    S. Utsunomiya; R.C. Ewing; L. Wang

    2005-06-13T23:59:59.000Z

    U{sup 6+}-phases are common alteration products, under oxidizing conditions, of uraninite and the UO{sub 2} in spent nuclear fuel. These U{sup 6+}-phases are subjected to a radiation field caused by the {alpha}-decay of U, or in the case of spent nuclear fuel, incorporated actinides, such as {sup 239}Pu and {sup 237}Np. In order to evaluate the effects of {alpha}-decay events on the stability of the U{sup 6+}-phases, we report, for the first time, the results of ion beam irradiations (1.0 MeV Kr{sup 2+}) of U{sup 6+}-phases. The heavy-particle irradiations are used to simulate the ballistic interactions of the recoil-nucleus of an {alpha}-decay event with the surrounding structure. The Kr{sup 2+}-irradiation decomposed the U{sup 6+}-phases to UO{sub 2} nanocrystals at doses as low as 0.006 displacements per atom (dpa). U{sup 6+}-phases accumulate substantial radiation doses ({approx}1.0 displacement per atom) within 100,000 years if the concentration of incorporated {sup 239}Pu is as high as 1 wt%. Similar nanocrystals of UO{sub 2} were observed in samples from the natural fission reactors at Oklo, Gabon. Multiple cycles of radiation-induced decomposition to UO{sub 2} followed by alteration to U{sup 6+}-phases provide a mechanism for the remobilization of incorporated radionuclides.

  7. Neurodegeneration and adaptation in response to low-dose photon irradiation

    SciTech Connect (OSTI)

    Limoli, Charles L. [UCI

    2014-10-27T23:59:59.000Z

    Neural stem and precursor cells (i.e. multipotent neural cells) are concentrated in the neurogenic regions of the brain (hippocampal dentate gyrus, subventricular zones), and considerable evidence suggests that these cells are important in mediating the stress response of the CNS after damage from ionizing radiation. The capability of these cells to proliferate, migrate and differentiate (i.e. to undergo neurogenesis) suggests they can participate in the repair and maintenance of CNS functions by replacing brain cells damaged or depleted due to irradiation. Importantly, we have shown that multipotent neural cells are markedly sensitive to irradiation and oxidative stress, insults that compromise neurogenesis and hasten the onset and progression of degenerative processes that are likely to have an adverse impact on cognition. Our past and current work has demonstrated that relatively low doses of radiation cause a persistent (weeks-months) oxidative stress in multipotent neural cells that can elicit a range of degenerative sequelae in the CNS. Therefore, our project is focused on determining the extent that endogenous and redox sensitive multipotent neural cells represent important radioresponsive targets for low dose radiation effects. We hypothesize that the activation of redox sensitive signaling can trigger radioadaptive changes in these cells that can be either harmful or beneficial to overall cognitive health.

  8. Roles of Sensory Nerves in the Regulation of Radiation-Induced Structural and Functional Changes in the Heart

    SciTech Connect (OSTI)

    Sridharan, Vijayalakshmi; Tripathi, Preeti [Department of Pharmaceutical Sciences, Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas (United States); Sharma, Sunil [Department of Radiation Oncology, Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas (United States); Moros, Eduardo G. [Department of Radiation Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida (United States); Zheng, Junying [Department of Pharmaceutical Sciences, Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas (United States); Hauer-Jensen, Martin [Department of Pharmaceutical Sciences, Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas (United States); Surgical Service, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas (United States); Boerma, Marjan, E-mail: mboerma@uams.edu [Department of Pharmaceutical Sciences, Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas (United States)

    2014-01-01T23:59:59.000Z

    Purpose: Radiation-induced heart disease (RIHD) is a chronic severe side effect of radiation therapy of intrathoracic and chest wall tumors. The heart contains a dense network of sensory neurons that not only are involved in monitoring of cardiac events such as ischemia and reperfusion but also play a role in cardiac tissue homeostasis, preconditioning, and repair. The purpose of this study was to examine the role of sensory nerves in RIHD. Methods and Materials: Male Sprague-Dawley rats were administered capsaicin to permanently ablate sensory nerves, 2 weeks before local image-guided heart x-ray irradiation with a single dose of 21 Gy. During the 6 months of follow-up, heart function was assessed with high-resolution echocardiography. At 6 months after irradiation, cardiac structural and molecular changes were examined with histology, immunohistochemistry, and Western blot analysis. Results: Capsaicin pretreatment blunted the effects of radiation on myocardial fibrosis and mast cell infiltration and activity. By contrast, capsaicin pretreatment caused a small but significant reduction in cardiac output 6 months after irradiation. Capsaicin did not alter the effects of radiation on cardiac macrophage number or indicators of autophagy and apoptosis. Conclusions: These results suggest that sensory nerves, although they play a predominantly protective role in radiation-induced cardiac function changes, may eventually enhance radiation-induced myocardial fibrosis and mast cell activity.

  9. Adaptation and adaptability : expectant design for resilience in coastal urbanity

    E-Print Network [OSTI]

    Ruskeepää, Laura A. Delaney (Laura Ashley Delaney)

    2011-01-01T23:59:59.000Z

    What is the nature of and possibility for urban resiliency through adaptation? Adaptation implies responsiveness to phenomena that are disruptive to a system's functioning; it is a willful evolution in response to changed ...

  10. Long-term Evaluation of Radiation-Induced Optic Neuropathy After Single-Fraction Stereotactic Radiosurgery

    SciTech Connect (OSTI)

    Leavitt, Jacqueline A., E-mail: leavitt.jacqueline@mayo.edu [Department of Ophthalmology, Mayo Clinic and Foundation, Rochester, Minnesota (United States); Stafford, Scott L. [Department of Radiation Oncology, Mayo Clinic and Foundation, Rochester, Minnesota (United States); Link, Michael J. [Department of Neurosurgery, Mayo Clinic and Foundation, Rochester, Minnesota (United States); Pollock, Bruce E. [Department of Radiation Oncology, Mayo Clinic and Foundation, Rochester, Minnesota (United States); Department of Neurosurgery, Mayo Clinic and Foundation, Rochester, Minnesota (United States)

    2013-11-01T23:59:59.000Z

    Purpose: To determine the long-term risk of radiation-induced optic neuropathy (RION) in patients having single-fraction stereotactic radiosurgery (SRS) for benign skull base tumors. Methods and Materials: Retrospective review of 222 patients having Gamma Knife radiosurgery for benign tumors adjacent to the anterior visual pathway (AVP) between 1991 and 1999. Excluded were patients with prior or concurrent external beam radiation therapy or SRS. One hundred twenty-nine patients (58%) had undergone previous surgery. Tumor types included confirmed World Health Organization grade 1 or presumed cavernous sinus meningioma (n=143), pituitary adenoma (n=72), and craniopharyngioma (n=7). The maximum dose to the AVP was ?8.0 Gy (n=126), 8.1-10.0 Gy (n=39), 10.1-12.0 Gy (n=47), and >12 Gy (n=10). Results: The mean clinical and imaging follow-up periods were 83 and 123 months, respectively. One patient (0.5%) who received a maximum radiation dose of 12.8 Gy to the AVP developed unilateral blindness 18 months after SRS. The chance of RION according to the maximum radiation dose received by the AVP was 0 (95% confidence interval [CI] 0-3.6%), 0 (95% CI 0-10.7%), 0 (95% CI 0-9.0%), and 10% (95% CI 0-43.0%) for patients receiving ?8 Gy, 8.1-10.0 Gy, 10.1-12.0 Gy, and >12 Gy, respectively. The overall risk of RION in patients receiving >8 Gy to the AVP was 1.0% (95% CI 0-6.2%). Conclusions: The risk of RION after single-fraction SRS in patients with benign skull base tumors who have no prior radiation exposure is very low if the maximum dose to the AVP is ?12 Gy. Physicians performing single-fraction SRS should remain cautious when treating lesions adjacent to the AVP, especially when the maximum dose exceeds 10 Gy.

  11. Poor Baseline Pulmonary Function May Not Increase the Risk of Radiation-Induced Lung Toxicity

    SciTech Connect (OSTI)

    Wang, Jingbo [Department of Radiation Oncology, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States) [Department of Radiation Oncology, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States); Department of Radiation Oncology, Cancer Hospital, Chinese Academic Medical Sciences and Peking Union Medical College, Beijing (China); Cao, Jianzhong [Department of Radiation Oncology, Cancer Hospital, Chinese Academic Medical Sciences and Peking Union Medical College, Beijing (China)] [Department of Radiation Oncology, Cancer Hospital, Chinese Academic Medical Sciences and Peking Union Medical College, Beijing (China); Yuan, Shuanghu [Department of Radiation Oncology, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States); Ji, Wei [Department of Radiation Oncology, Cancer Hospital, Chinese Academic Medical Sciences and Peking Union Medical College, Beijing (China)] [Department of Radiation Oncology, Cancer Hospital, Chinese Academic Medical Sciences and Peking Union Medical College, Beijing (China); Arenberg, Douglas [Department of Internal Medicine, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States)] [Department of Internal Medicine, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States); Dai, Jianrong [Department of Radiation Oncology, Cancer Hospital, Chinese Academic Medical Sciences and Peking Union Medical College, Beijing (China)] [Department of Radiation Oncology, Cancer Hospital, Chinese Academic Medical Sciences and Peking Union Medical College, Beijing (China); Stanton, Paul; Tatro, Daniel; Ten Haken, Randall K. [Department of Radiation Oncology, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States); Wang, Luhua, E-mail: wlhwq@yahoo.com [Department of Radiation Oncology, Cancer Hospital, Chinese Academic Medical Sciences and Peking Union Medical College, Beijing (China)] [Department of Radiation Oncology, Cancer Hospital, Chinese Academic Medical Sciences and Peking Union Medical College, Beijing (China); Kong, Feng-Ming, E-mail: fengkong@med.umich.edu [Department of Radiation Oncology, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan/Ann Arbor Veterans Health System, Ann Arbor, Michigan (United States)

    2013-03-01T23:59:59.000Z

    Purpose: Poor pulmonary function (PF) is often considered a contraindication to definitive radiation therapy for lung cancer. This study investigated whether baseline PF was associated with radiation-induced lung toxicity (RILT) in patients with non-small cell lung cancer (NSCLC) receiving conformal radiation therapy (CRT). Methods and Materials: NSCLC patients treated with CRT and tested for PF at baseline were eligible. Baseline predicted values of forced expiratory volume in 1 sec (FEV1), forced vital capacity (FVC), and diffusion capacity of lung for carbon monoxide (DLCO) were analyzed. Additional factors included age, gender, smoking status, Karnofsky performance status, coexisting chronic obstructive pulmonary disease (COPD), tumor location, histology, concurrent chemotherapy, radiation dose, and mean lung dose (MLD) were evaluated for RILT. The primary endpoint was symptomatic RILT (SRILT), including grade ?2 radiation pneumonitis and fibrosis. Results: There was a total of 260 patients, and SRILT occurred in 58 (22.3%) of them. Mean FEV1 values for SRILT and non-SRILT patients were 71.7% and 65.9% (P=.077). Under univariate analysis, risk of SRILT increased with MLD (P=.008), the absence of COPD (P=.047), and FEV1 (P=.077). Age (65 split) and MLD were significantly associated with SRILT in multivariate analysis. The addition of FEV1 and age with the MLD-based model slightly improved the predictability of SRILT (area under curve from 0.63-0.70, P=.088). Conclusions: Poor baseline PF does not increase the risk of SRILT, and combining FEV1, age, and MLD may improve the predictive ability.

  12. Adaptive Survey Design Andrew Sage

    E-Print Network [OSTI]

    Carriquiry, Alicia

    . Andrew Sage Iowa State University CSSM March 14, 2014 2 / 35 #12;Adaptive and Responsive Designs collection, although they may be revised during data collection. A responsive design is an adaptive design

  13. REGULATORY MECHANISMS OF SLC39A4 (ZIP4) AND SLC39A5 (ZIP5) IN THE ADAPTIVE RESPONSE TO ZINC AVAILABILITY

    E-Print Network [OSTI]

    Weaver, Benjamin Patrick

    2009-04-06T23:59:59.000Z

    REGULATORY MECHANISMS OF SLC39A4 (ZIP4) AND SLC39A5 (ZIP5) IN THE ADAPTIVE RESPONSE TO ZINC AVAILABILITY by Copyright 2009 Benjamin Patrick Weaver B.S., Biochemistry, Wichita State University, Wichita, KS, 2001 M.S., Biological Sciences... of esoteric conversations, and for your friendship. Thank you for putting up with me and for always listening. The friendship of some other previous lab members: Yong Li for your friendship and suffering my mispronounced Chinese. Taiho Kambe...

  14. RADIATION-INDUCED DECOMPOSITION OF U(VI) ALTERATION PHASES OF UO2

    SciTech Connect (OSTI)

    S. Utsunomiya; R.C. Ewing

    2005-09-08T23:59:59.000Z

    U{sup 6+}-phases are common alteration products of spent nuclear fuel under oxidizing conditions, and they may potentially incorporate actinides, such as long-lived {sup 239}Pu and {sup 237}Np, delaying their transport to the biosphere. In order to evaluate the ballistic effects of {alpha}-decay events on the stability of the U{sup 6+}-phases, we report, for the first time, the results of ion beam irradiations (1.0 MeV Kr{sup 2+}) for six different structures of U{sup 6+}-phases: uranophane, kasolite, boltwoodite, saleeite, carnotite, and liebigite. The target uranyl-minerals were characterized by powder X-ray diffraction and identification confirmed by SAED (selected area electron diffraction) in TEM (transmission electron microscopy). The TEM observation revealed no initial contamination of uraninite in these U{sup 6+} phases. All of the samples were irradiated with in situ TEM observation using 1.0 MeV Kr{sup 2+} in the IVEM (intermediate-voltage electron microscope) at the IVEM-Tandem Facility of Argonne National Laboratory. The ion flux was 6.3 x 10{sup 11} ions/cm{sup 2}/sec. The specimen temperatures during irradiation were 298 and 673 K, respectively. The Kr{sup 2+}-irradiation decomposed the U{sup 6+}-phases to nanocrystals of UO{sub 2} at doses as low as 0.006 dpa. The cumulative doses for the pure U{sup 6+}-phases, e.g., uranophane, at 0.1 and 1 million years (m.y.) are calculated to be 0.009 and 0.09 dpa using SRIM2003. However, with the incorporation of 1 wt.% {sup 239}Pu, the calculated doses reach 0.27 and {approx}1.00 dpa in ten thousand and one hundred thousand years, respectively. Under oxidizing conditions, multiple cycles of radiation-induced decomposition to UO{sub 2} followed by alteration to U{sup 6+}-phases should be further investigated to determine the fate of trace elements that may have been incorporated in the U{sup 6+}-phases.

  15. Amifostine, a radioprotectant agent, protects rat brain tissue lipids against ionizing radiation induced damage: An FTIR microspectroscopic imaging study

    SciTech Connect (OSTI)

    Cakmak G.; Miller L.; Zorlu, F.; Severcan, F.

    2012-03-03T23:59:59.000Z

    Amifostine is the only approved radioprotective agent by FDA for reducing the damaging effects of radiation on healthy tissues. In this study, the protective effect of amifostine against the damaging effects of ionizing radiation on the white matter (WM) and grey matter (GM) regions of the rat brain were investigated at molecular level. Sprague-Dawley rats, which were administered amifostine or not, were whole-body irradiated at a single dose of 800 cGy, decapitated after 24 h and the brain tissues of these rats were analyzed using Fourier transform infrared microspectroscopy (FTIRM). The results revealed that the total lipid content and CH{sub 2} groups of lipids decreased significantly and the carbonyl esters, olefinic=CH and CH{sub 3} groups of lipids increased significantly in the WM and GM after exposure to ionizing radiation, which could be interpreted as a result of lipid peroxidation. These changes were more prominent in the WM of the brain. The administration of amifostine before ionizing radiation inhibited the radiation-induced lipid peroxidation in the brain. In addition, this study indicated that FTIRM provides a novel approach for monitoring ionizing radiation induced-lipid peroxidation and obtaining different molecular ratio images can be used as biomarkers to detect lipid peroxidation in biological systems.

  16. Radiation hardening and radiation-induced chromium depletion effects on intergranular stress corrosion cracking of austenitic stainless steels

    SciTech Connect (OSTI)

    Bruemmer, S.M.; Simonen, E.P.

    1993-03-01T23:59:59.000Z

    Available data on neutron-irradiated materials have been analyzed and correlations developed between fluence, yield strength, grain boundary chromium concentration and cracking susceptibility in high-temperature water environments. Large heat-to-heat differences in critical fluence (0.2 to 2.5 n/cm[sup 2]) for IGSCC are documented.In many cases, this variability is consistent with yield strength differences among irradiated materials. IGSCC correlated better to yield strength than to fluence for most heats suggesting a possible role of the radiation-induced hardening (and microstructure) on cracking. However, isolatedheats reveal a wide range of yield strengths from 450 to 800 MPa necessary to promote IGSCC which cannot be understood by strength effects alone. Grain boundary Cr depletion explain differences in IGSCC susceptibility for irradiated stainless steels. Cr contents versus SCC shows that all materials showing IG cracking have some grain boundary depletion ([ge]2%). Grain boundary Cr concentrations for cracking (below [approximately]16 wt %) are in good agreement with similar SCC tests on unirradiated 304 SS with controlled depletion profiles. Heats that prompt variability in the yield strength correlation, are accounted for bydifferences in their interfacial Cr contents. Certain stainless steels are more resistant to cracking even though they have significant radiation-induced Cr depletion. It is proposed that Cr depletion is required for IASCC, but observed susceptibility is modified by other microchemical and microstructural components.

  17. Radiation hardening and radiation-induced chromium depletion effects on intergranular stress corrosion cracking of austenitic stainless steels

    SciTech Connect (OSTI)

    Bruemmer, S.M.; Simonen, E.P.

    1993-03-01T23:59:59.000Z

    Available data on neutron-irradiated materials have been analyzed and correlations developed between fluence, yield strength, grain boundary chromium concentration and cracking susceptibility in high-temperature water environments. Large heat-to-heat differences in critical fluence (0.2 to 2.5 n/cm{sup 2}) for IGSCC are documented.In many cases, this variability is consistent with yield strength differences among irradiated materials. IGSCC correlated better to yield strength than to fluence for most heats suggesting a possible role of the radiation-induced hardening (and microstructure) on cracking. However, isolatedheats reveal a wide range of yield strengths from 450 to 800 MPa necessary to promote IGSCC which cannot be understood by strength effects alone. Grain boundary Cr depletion explain differences in IGSCC susceptibility for irradiated stainless steels. Cr contents versus SCC shows that all materials showing IG cracking have some grain boundary depletion ({ge}2%). Grain boundary Cr concentrations for cracking (below {approximately}16 wt %) are in good agreement with similar SCC tests on unirradiated 304 SS with controlled depletion profiles. Heats that prompt variability in the yield strength correlation, are accounted for bydifferences in their interfacial Cr contents. Certain stainless steels are more resistant to cracking even though they have significant radiation-induced Cr depletion. It is proposed that Cr depletion is required for IASCC, but observed susceptibility is modified by other microchemical and microstructural components.

  18. Quantification of radiation induced crosslinking in a commercial, toughened silicone rubber, TR-55, by 1H MQ-NMR

    SciTech Connect (OSTI)

    Maxwell, R; Chinn, S; Alviso, C; Harvey, C A; Giuliani, J; Wilson, T; Cohenour, R

    2008-11-10T23:59:59.000Z

    Radiation induced degradation in a commercial, filled silicone composite has been studied by SPME/GC-MS, DMA, DSC, swelling, and Multiple Quantum NMR. Analysis of volatile and semivolatile species indicates degradation via decomposition of the peroxide curing catalyst and radiation induced backbiting reactions. DMA, swelling, and spin-echo NMR analysis indicate a increase in crosslink density of near 100% upon exposure to a cumulative dose of 250 kGray. Analysis of the sol-fraction via Charlseby-Pinner analysis indicates a ratio of chain scission to crosslinking yields of 0.38, consistent with the dominance of the crosslinking observed by DMA, swelling and spin-echo NMR and the chain scissioning reactions observed by MS analysis. Multiple Quantum NMR has revealed a bimodal distribution of residual dipolar couplings near 1 krad/sec and 5 krad/sec in an approximately 90:10 ratio, consistent with bulk network chains and chains associated with the filler surface. Upon exposure to radiation, the mean {Omega}{sub d} for both domains and the width of both domains both increased. The MQ NMR analysis provided increase insight into the effects of ionizing radiation on the network structure of silicone polymers.

  19. Synchrotron radiation induced x-ray micro analysis: A realistic alternative for electron- and ion beam microscopy?

    SciTech Connect (OSTI)

    Janssens, K.; Adams, F. [Universitaire Instelling Antwerpen, Antwerp (Belgium). Dept. of Chemistry; Rivers, M.L.; Jones, K.W. [Brookhaven National Lab., Upton, NY (United States)

    1992-10-01T23:59:59.000Z

    Synchrotron Radiation induced X-ray micro Fluorescence analysis ({mu}-SRXRF) is compared with more conventional microanalytical techniques such as Secondary Ion Microscopy (SIMS) and Electron Probe X-ray Microanalysis (EPXMA) for two typical microanalytical applications. SRXRF and EPXMA are employed for the analysis of individual particles, showing the complementary character of both techniques. By means of element mapping of trace constituents in a heterogeneous feldspar, the strong and weak points of SRXRF in comparison to EPXMA and SIMS are illustrated. The most striking difference between SRXRF and the other two microanalytical methods is the ability of SRXRF to probe deep into the investigated Material, whereas SIMS and EPXMA only investigate the upper surface of the material. The possibilities of SRXRF at third generation synchrotron rings is also briefly discussed.

  20. Synchrotron radiation induced x-ray micro analysis: A realistic alternative for electron- and ion beam microscopy

    SciTech Connect (OSTI)

    Janssens, K.; Adams, F. (Universitaire Instelling Antwerpen, Antwerp (Belgium). Dept. of Chemistry); Rivers, M.L.; Jones, K.W. (Brookhaven National Lab., Upton, NY (United States))

    1992-01-01T23:59:59.000Z

    Synchrotron Radiation induced X-ray micro Fluorescence analysis ([mu]-SRXRF) is compared with more conventional microanalytical techniques such as Secondary Ion Microscopy (SIMS) and Electron Probe X-ray Microanalysis (EPXMA) for two typical microanalytical applications. SRXRF and EPXMA are employed for the analysis of individual particles, showing the complementary character of both techniques. By means of element mapping of trace constituents in a heterogeneous feldspar, the strong and weak points of SRXRF in comparison to EPXMA and SIMS are illustrated. The most striking difference between SRXRF and the other two microanalytical methods is the ability of SRXRF to probe deep into the investigated Material, whereas SIMS and EPXMA only investigate the upper surface of the material. The possibilities of SRXRF at third generation synchrotron rings is also briefly discussed.

  1. A physical model of the photo- and radiation-induced degradation of ytterbium-doped silica optical fibres

    SciTech Connect (OSTI)

    Mady, Franck, E-mail: franck.mady@unice.fr; Duchez, Jean-Bernard, E-mail: franck.mady@unice.fr; Mebrouk, Yasmine, E-mail: franck.mady@unice.fr; Benabdesselam, Mourad, E-mail: franck.mady@unice.fr [University of Nice Sophia Antipolis, Laboratoire de Physique de la Matière Condensée (LPMC), CNRS UMR 7336, Parc Valrose, 06108 Nice cedex 2 (France)

    2014-10-21T23:59:59.000Z

    We propose a model to describe the photo- or/and the radiation-induced darkening of ytterbium-doped silica optical fibers. This model accounts for the well-established experimental features of photo-darkening. Degradation behaviors predicted for fibers pumped in harsh environments are also fully confirmed by experimental data reported in the work by Duchez et al. (this proceeding), which gives a detailed characterization of the interplay between the effects of the pump and those of a superimposed ionizing irradiation (actual operation conditions in space-based applications for instance). In particular, dependences of the darkening build-up on the pump power, the total ionizing dose and the dose rate are all correctly reproduced. The presented model is a ‘sufficient’ one, including the minimal physical ingredients required to reproduce experimental features. Refinements could be proposed to improve, e.g., quantitative kinetics.

  2. Evaluation of Reaction Rate Theory and Monte Carlo Methods for Application to Radiation-Induced Microstructural Characterization

    SciTech Connect (OSTI)

    Stoller, Roger E [ORNL; Golubov, Stanislav I [ORNL; Becquart, C. S. [Universite de Lille; Domain, C. [EDF R& D, Clamart, France

    2007-08-01T23:59:59.000Z

    The multiscale modeling scheme encompasses models from the atomistic to the continuum scale. Phenomena at the mesoscale are typically simulated using reaction rate theory, Monte Carlo, or phase field models. These mesoscale models are appropriate for application to problems that involve intermediate length scales, and timescales from those characteristic of diffusion to long-term microstructural evolution (~?s to years). Although the rate theory and Monte Carlo models can be used simulate the same phenomena, some of the details are handled quite differently in the two approaches. Models employing the rate theory have been extensively used to describe radiation-induced phenomena such as void swelling and irradiation creep. The primary approximations in such models are time- and spatial averaging of the radiation damage source term, and spatial averaging of the microstructure into an effective medium. Kinetic Monte Carlo models can account for these spatial and temporal correlations; their primary limitation is the computational burden which is related to the size of the simulation cell. A direct comparison of RT and object kinetic MC simulations has been made in the domain of point defect cluster dynamics modeling, which is relevant to the evolution (both nucleation and growth) of radiation-induced defect structures. The primary limitations of the OKMC model are related to computational issues. Even with modern computers, the maximum simulation cell size and the maximum dose (typically much less than 1 dpa) that can be simulated are limited. In contrast, even very detailed RT models can simulate microstructural evolution for doses up 100 dpa or greater in clock times that are relatively short. Within the context of the effective medium, essentially any defect density can be simulated. Overall, the agreement between the two methods is best for irradiation conditions which produce a high density of defects (lower temperature and higher displacement rate), and for materials that have a relatively high density of fixed sinks such as dislocations.

  3. Reproductive Status at First Diagnosis Influences Risk of Radiation-Induced Second Primary Contralateral Breast Cancer in the WECARE Study

    SciTech Connect (OSTI)

    Brooks, Jennifer D., E-mail: brooksj@mskcc.org [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Boice, John D. [International Epidemiology Institute, Rockville, MD and Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt School of Medicine, Nashville, TN (United States)] [International Epidemiology Institute, Rockville, MD and Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt School of Medicine, Nashville, TN (United States); Stovall, Marilyn [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Reiner, Anne S. [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)] [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Bernstein, Leslie [Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (United States)] [Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA (United States); John, Esther M. [Cancer Prevention Institute of California, Fremont, CA, and Stanford University School of Medicine and Stanford Cancer Institute, Stanford, CA (United States)] [Cancer Prevention Institute of California, Fremont, CA, and Stanford University School of Medicine and Stanford Cancer Institute, Stanford, CA (United States); Lynch, Charles F. [Department of Epidemiology, University of Iowa, Iowa City, IA (United States)] [Department of Epidemiology, University of Iowa, Iowa City, IA (United States); Mellemkjaer, Lene [Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen (Denmark)] [Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen (Denmark); Knight, Julia A. [Dalla Lana School of Public Health, University of Toronto and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario (Canada)] [Dalla Lana School of Public Health, University of Toronto and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario (Canada); Thomas, Duncan C.; Haile, Robert W. [Department of Preventive Medicine, University of Southern California, Los Angeles, CA (United States)] [Department of Preventive Medicine, University of Southern California, Los Angeles, CA (United States); Smith, Susan A. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Capanu, Marinela; Bernstein, Jonine L. [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States)] [Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Shore, Roy E. [Department of Environmental Medicine, New York University, New York, NY (United States) [Department of Environmental Medicine, New York University, New York, NY (United States); Radiation Effects Research Foundation, Hiroshima (Japan)

    2012-11-15T23:59:59.000Z

    Purpose: Our study examined whether reproductive and hormonal factors before, at the time of, or after radiation treatment for a first primary breast cancer modify the risk of radiation-induced second primary breast cancer. Methods and Materials: The Women's Environmental, Cancer and Radiation Epidemiology (WECARE) Study is a multicenter, population-based study of 708 women (cases) with asynchronous contralateral breast cancer (CBC) and 1399 women (controls) with unilateral breast cancer. Radiotherapy (RT) records, coupled with anthropomorphic phantom simulations, were used to estimate quadrant-specific radiation dose to the contralateral breast for each patient. Rate ratios (RR) and 95% confidence intervals (CI) were computed to assess the relationship between reproductive factors and risk of CBC. Results: Women who were nulliparous at diagnosis and exposed to {>=}1 Gy to the contralateral breast had a greater risk for CBC than did matched unexposed nulliparous women (RR = 2.2; 95% CI, 1.2-4.0). No increased risk was seen in RT-exposed parous women (RR = 1.1; 95% CI, 0.8-1.4). Women treated with RT who later became pregnant (8 cases and 9 controls) had a greater risk for CBC (RR = 6.0; 95% CI, 1.3-28.4) than unexposed women (4 cases and 7 controls) who also became pregnant. The association of radiation with risk of CBC did not vary by number of pregnancies, history of breastfeeding, or menopausal status at the time of first breast cancer diagnosis. Conclusion: Nulliparous women treated with RT were at an increased risk for CBC. Although based on small numbers, women who become pregnant after first diagnosis also seem to be at an increased risk for radiation-induced CBC.

  4. Radiation-Induced Micro-RNA Expression Changes in Peripheral Blood Cells of Radiotherapy Patients

    SciTech Connect (OSTI)

    Templin, Thomas; Paul, Sunirmal; Amundson, Sally A.; Young, Erik F. [Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, New York, NY (United States); Barker, Christopher A.; Wolden, Suzanne L. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Smilenov, Lubomir B., E-mail: lbs5@columbia.ed [Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, New York, NY (United States)

    2011-06-01T23:59:59.000Z

    Purpose: MicroRNAs (miRNAs), a class of noncoding small RNAs that regulate gene expression, are involved in numerous physiologic processes in normal and malignant cells. Our in vivo study measured miRNA and gene expression changes in human blood cells in response to ionizing radiation, to develop miRNA signatures that can be used as biomarkers for radiation exposure. Methods and Materials: Blood from 8 radiotherapy patients in complete remission 1 or 2 was collected immediately before and 4 hours after total body irradiation with 1.25 Gy x-rays. Both miRNA and gene expression changes were measured by means of quantitative polymerase chain reaction and microarray hybridization, respectively. Hierarchic clustering, multidimensional scaling, class prediction, and gene ontology analysis were performed to investigate the potential of miRNAs to serve as radiation biomarkers and to elucidate their likely physiologic roles in the radiation response. Results: The expression levels of 45 miRNAs were statistically significantly upregulated 4 hours after irradiation with 1.25 Gy x-rays, 27 of them in every patient. Nonirradiated and irradiated samples form separate clusters in hierarchic clustering and multidimensional scaling. Out of 223 differentially expressed genes, 37 were both downregulated and predicted targets of the upregulated miRNAs. Paired and unpaired miRNA-based classifiers that we developed can predict the class membership of a sample with unknown irradiation status, with accuracies of 100% when all 45 upregulated miRNAs are included. Both miRNA control of and gene involvement in biologic processes such as hemopoiesis and the immune response are increased after irradiation, whereas metabolic processes are underrepresented among all differentially expressed genes and the genes controlled by miRNAs. Conclusions: Exposure to ionizing radiation leads to the upregulation of the expression of a considerable proportion of the human miRNAome of peripheral blood cells. These miRNA expression signatures can be used as biomarkers of radiation exposure.

  5. Radiation-induced gain degradation in lateral PNP BJTs with lightly and heavily doped emitters

    SciTech Connect (OSTI)

    Wu, A. [Univ. of Arizona, Tucson, AZ (United States); Schrimpf, R.D. [Vanderbilt Univ., Nashville, TN (United States); Pease, R.L. [RLP Research, Inc., Albuquerque, NM (United States); Fleetwood, D.M. [Sandia National Labs., Albuquerque, NM (United States); Kosier, S.L. [VTC Inc., Bloomington, MN (United States)

    1997-06-01T23:59:59.000Z

    Ionizing radiation may cause failures in ICs due to gain degradation of individual devices. The base current of irradiated bipolar devices increases with total dose, while the collector current remains relatively constant. This results in a decrease in the current gain. Lateral PNP (LPNP) transistors typically exhibit more degradation than vertical PNP devices at the same total dose, and have been blamed as the cause of early IC failures at low dose rates. It is important to understand the differences in total-dose response between devices with heavily- and lightly-doped emitters in order to compare different technologies and evaluate the applicability of proposed low-dose-rate hardness-assurance methods. This paper addresses these differences by comparing two different LPNP devices from the same process: one with a heavily-doped emitter and one with a lightly-doped emitter. Experimental results demonstrate that the lightly-doped devices are more sensitive to ionizing radiation and simulations illustrate that increased recombination on the emitter side of the junction is responsible for the higher sensitivity.

  6. Interactions of foot-and-mouth disease virus with cells in organised lymphoid tissue influence innate and adaptive immune responses 

    E-Print Network [OSTI]

    Juleff, Nicholas Dylan

    2009-01-01T23:59:59.000Z

    to that in the controls, including rapid isotype switching to IgG antibody. These data suggest that antibody responses to sites on the surface of the virus capsid are T cell-independent whereas those directed against the non-structural proteins are T cell-dependent. CD4...

  7. Comparison of radiation exposure and associated radiation-induced cancer risks from mammography and molecular imaging of the breast

    SciTech Connect (OSTI)

    O'Connor, Michael K.; Li Hua; Rhodes, Deborah J.; Hruska, Carrie B.; Clancy, Conor B.; Vetter, Richard J. [Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905 (United States); Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905 (United States); Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905 (United States); Department of Medical Physics, St. James's Hospital, Dublin (Ireland); Radiation Safety, Mayo Clinic, Rochester, Minnesota 55905 (United States)

    2010-12-15T23:59:59.000Z

    Purpose: Recent studies have raised concerns about exposure to low-dose ionizing radiation from medical imaging procedures. Little has been published regarding the relative exposure and risks associated with breast imaging techniques such as breast specific gamma imaging (BSGI), molecular breast imaging (MBI), or positron emission mammography (PEM). The purpose of this article was to estimate and compare the risks of radiation-induced cancer from mammography and techniques such as PEM, BSGI, and MBI in a screening environment. Methods: The authors used a common scheme for all estimates of cancer incidence and mortality based on the excess absolute risk model from the BEIR VII report. The lifetime attributable risk model was used to estimate the lifetime risk of radiation-induced breast cancer incidence and mortality. All estimates of cancer incidence and mortality were based on a population of 100 000 females followed from birth to age 80 and adjusted for the fraction that survives to various ages between 0 and 80. Assuming annual screening from ages 40 to 80 and from ages 50 to 80, the cumulative cancer incidence and mortality attributed to digital mammography, screen-film mammography, MBI, BSGI, and PEM was calculated. The corresponding cancer incidence and mortality from natural background radiation was calculated as a useful reference. Assuming a 15%-32% reduction in mortality from screening, the benefit/risk ratio for the different imaging modalities was evaluated. Results: Using conventional doses of 925 MBq Tc-99m sestamibi for MBI and BSGI and 370 MBq F-18 FDG for PEM, the cumulative cancer incidence and mortality were found to be 15-30 times higher than digital mammography. The benefit/risk ratio for annual digital mammography was >50:1 for both the 40-80 and 50-80 screening groups, but dropped to 3:1 for the 40-49 age group. If the primary use of MBI, BSGI, and PEM is in women with dense breast tissue, then the administered doses need to be in the range 75-150 MBq for Tc-99m sestamibi and 35 MBq-70 MBq for F-18 FDG in order to obtain benefit/risk ratios comparable to those of mammography in these age groups. These dose ranges should be achievable with enhancements to current technology while maintaining a reasonable examination time. Conclusions: The results of the dose estimates in this study clearly indicate that if molecular imaging techniques are to be of value in screening for breast cancer, then the administered doses need to be substantially reduced to better match the effective doses of mammography.

  8. Adapting the U.S. Domestic Radiological Emergency Response Process to an Overseas Incident: FRMAC Without the F

    SciTech Connect (OSTI)

    Blumenthal, Daniel J. [USDOE NA Office of Emergency Response; Bowman, David R. [USDOE NA Office of Emergency Response; Remick, Alan [USDOE NA Office of Emergency Response

    2012-05-01T23:59:59.000Z

    The earthquake and resulting tsunami in Japan led to a radiological release from the Fukushima Daiichi Nuclear Power Plan, which in turn resulted in the rapid activation and deployment by the U.S. Department of Energy National Nuclear Security Administration (DOE/NNSA) emergency response teams. These teams and those from other federal agencies are typically coordinated through the Federal Radiological Monitoring and Assessment Center (FRMAC) when responding to radiological incidents in the U.S. FRMAC is the body through which the collection, analysis, and assessment of environmental radiological data are coordinated and products released to decision makers. This article discusses DOE/NNSA’s role in the U.S. response to the Fukushima accident as it implemented its components of FRMAC in a foreign country, coordinated its assets, integrated with its federal partners, and collaborated with the Government of Japan. The technical details of the various data collections and analyses are covered in other articles of this issue.

  9. Molecular analysis of radiation-induced albino (c)-locus mutations that cause death at preimplantation stages of development

    SciTech Connect (OSTI)

    Rinchik, E.M. (Oak Ridge National Lab., TN (United States)); Toenjes, R.R.; Paul, D. (Fraunhofer-Instituet fuer Toxikologie und Aerosolforschung, Hannover (Germany)); Potter, M.D. (Univ. of Tenn.-Oak Ridge Graduate School of Biomedical Sciences, Oak Ridge, TN (United States))

    1993-12-01T23:59:59.000Z

    Deletion mutations at the albino (c) locus have been useful for continuing the development of fine-structure physical and functional maps of the Fes-Hbb region of mouse chromosome 7. This report describes the molecular analysis of a number of radiation-induced c deletions that, when homozygous, cause death of the embryo during preimplantation stages. The distal extent of these deletions defines a locus, pid, (preimplantation development) genetically associated with this phenotype. The proximal breakpoints of eight of these deletions were mapped with respect to the Tyr (tyrosinase; albino) gene as well as to anonymous loci within the Fah-Tyr region that are defined by the Pmv-31 viral integration site and by chromosome-microdissection clones. Rearrangements corresponding to the proximal breakpoints of two of these deletions were detected by Southern blot analysis, and a size-altered restriction fragment carrying the breakpoint of one of them was cloned. A probe derived from this deletion fusion fragment defines a locus, D7Rn6, which maps within (or distal to) the pid region, and which discriminates among the distal extents of deletions eliciting the pid phenotype. Extension of physical maps from D7Rn6 should provide access both to the pid region and to loci mapping distal to pid that are defined by N-ethyl-N-nitrosourea-induced lethal mutations. 36 refs., 10 figs.

  10. The prediction of radiation-induced liver dysfunction using a local dose and regional venous perfusion model

    SciTech Connect (OSTI)

    Cao Yue; Platt, Joel F.; Francis, Isaac R; Balter, James M.; Pan, Charlie; Normolle, Daniel; Ben-Josef, Edgar; Haken, Randall K. ten; Lawrence, Theodore S. [Departments of Radiation Oncology and Radiology, University of Michigan, Ann Arbor, Michigan 48109-0010 (United States); Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109-0010 (United States); Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109-0010 (United States)

    2007-02-15T23:59:59.000Z

    We have shown that high dose conformal radiation combined with chemotherapy appears to prolong the survival of patients with unresectable intrahepatic cancers. The ability to safely deliver higher doses is primarily limited by the development of radiation-induced liver disease, characterized by venous occlusion. In this study, we investigated whether portal venous perfusion measured prior to the end of radiation therapy (RT) together with dose could predict liver venous perfusion dysfunction after treatment. Ten patients with unresectable intrahepatic cancer participated in an IRB-approved computer tomography (CT) perfusion study. Hepatic arterial and portal vein perfusion distributions were estimated by using dynamic contrast enhanced CT and the single compartmental model. Scans were obtained at four time points: prior to treatment, after 15 and 30 fractions of 1.5 Gy treatments, and one month following the completion of RT. Multivariant linear regression was used to determine covariances among the first three time point measurements plus dose for prediction of the post RT measurement. The reduction in the regional venous perfusion one month following RT was predicted by the local accumulated dose and the change in the regional venous perfusion after {approx}30 fractions (F=90.6,p<0.000 01). Each Gy produced an approximately 1.2% of reduction in the venous perfusion. This local dose and venous perfusion model has the potential to predict individual sensitivity to radiation. This is the first step toward developing a method to deliver higher and potentially more curative radiation doses to the patients who can safely receive these higher doses.

  11. Response

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn'tOrigin ofEnergy at Waste-to-Energy usingof Enhanced Dr. JuliaPOINTRespond to theResponse SEAB

  12. A tale of two houses: the human dimension of demand response enabling technology from a case study of an adaptive wireless thermostat.

    E-Print Network [OSTI]

    Peffer, Therese; Arens, Edward A; Chen, Xue; Jang, Jaehwi; Auslander, David M.

    2008-01-01T23:59:59.000Z

    and Ed Arens. 2008. Demand Response-Enabled ResidentialEfficiency and Demand Response Programs for 2005/2006.The Human Dimension of Demand Response Enabling Technology

  13. Radiation-Induced Rib Fractures After Hypofractionated Stereotactic Body Radiation Therapy: Risk Factors and Dose-Volume Relationship

    SciTech Connect (OSTI)

    Asai, Kaori [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan)] [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan); Shioyama, Yoshiyuki, E-mail: shioyama@radiol.med.kyushu-u.ac.jp [Department of Heavy Particle Therapy and Radiation Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan)] [Department of Heavy Particle Therapy and Radiation Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan); Nakamura, Katsumasa; Sasaki, Tomonari; Ohga, Saiji; Nonoshita, Takeshi [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan)] [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan); Yoshitake, Tadamasa [Department of Heavy Particle Therapy and Radiation Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan)] [Department of Heavy Particle Therapy and Radiation Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan); Ohnishi, Kayoko [Department of Radiology, National Center for Global Health and Medicine, Tokyo (Japan)] [Department of Radiology, National Center for Global Health and Medicine, Tokyo (Japan); Terashima, Kotaro; Matsumoto, Keiji [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan)] [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan); Hirata, Hideki [Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan)] [Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan); Honda, Hiroshi [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan)] [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan)

    2012-11-01T23:59:59.000Z

    Purpose: The purpose of this study was to clarify the incidence, the clinical risk factors, and the dose-volume relationship of radiation-induced rib fracture (RIRF) after hypofractionated stereotactic body radiation therapy (SBRT). Methods and Materials: One hundred sixteen patients treated with SBRT for primary or metastatic lung cancer at our institution, with at least 6 months of follow-up and no previous overlapping radiation exposure, were included in this study. To determine the clinical risk factors associated with RIRF, correlations between the incidence of RIRF and the variables, including age, sex, diagnosis, gross tumor volume diameter, rib-tumor distance, and use of steroid administration, were analyzed. Dose-volume histogram analysis was also conducted. Regarding the maximum dose, V10, V20, V30, and V40 of the rib, and the incidences of RIRF were compared between the two groups divided by the cutoff value determined by the receiver operating characteristic curves. Results: One hundred sixteen patients and 374 ribs met the inclusion criteria. Among the 116 patients, 28 patients (46 ribs) experienced RIRF. The estimated incidence of rib fracture was 37.7% at 3 years. Limited distance from the rib to the tumor (<2.0 cm) was the only significant risk factor for RIRF (p = 0.0001). Among the dosimetric parameters used for receiver operating characteristic analysis, the maximum dose showed the highest area under the curve. The 3-year estimated risk of RIRF and the determined cutoff value were 45.8% vs. 1.4% (maximum dose, {>=}42.4 Gy or less), 51.6% vs. 2.0% (V40, {>=}0.29 cm{sup 3} or less), 45.8% vs. 2.2% (V30, {>=}1.35 cm{sup 3} or less), 42.0% vs. 8.5% (V20, {>=}3.62 cm{sup 3} or less), or 25.9% vs. 10.5% (V10, {>=}5.03 cm{sup 3} or less). Conclusions: The incidence of RIRF after hypofractionated SBRT is relatively high. The maximum dose and high-dose volume are strongly correlated with RIRF.

  14. COMMENTARY:Limits to adaptation

    SciTech Connect (OSTI)

    Preston, Benjamin L [ORNL

    2013-01-01T23:59:59.000Z

    An actor-centered, risk-based approach to defining limits to social adaptation provides a useful analytic framing for identifying and anticipating these limits and informing debates over society s responses to climate change.

  15. DNA repair efficiency in germ cells and early mouse embryos and consequences for radiation-induced transgenerational genomic damage

    E-Print Network [OSTI]

    Marchetti, Francesco

    2009-01-01T23:59:59.000Z

    Kastan, M. B. (1997). DNA damage induces phosphorylation ofby ATM in response to DNA damage. Science 281, Barber, R. ,Nussenzweig, A. (2002). DNA damage-induced G2-M checkpoint

  16. Adaptive method with intercessory feedback control for an intelligent agent

    DOE Patents [OSTI]

    Goldsmith, Steven Y.

    2004-06-22T23:59:59.000Z

    An adaptive architecture method with feedback control for an intelligent agent provides for adaptively integrating reflexive and deliberative responses to a stimulus according to a goal. An adaptive architecture method with feedback control for multiple intelligent agents provides for coordinating and adaptively integrating reflexive and deliberative responses to a stimulus according to a goal. Re-programming of the adaptive architecture is through a nexus which coordinates reflexive and deliberator components.

  17. Radiation-induced instability of MnS precipitates and its possible consequences on irradiation-induced stress corrosion cracking of austenitic stainless steels

    SciTech Connect (OSTI)

    Chung, H.M.; Sanecki, J.E. [Argonne National Lab., IL (United States); Garner, F.A. [Pacific Northwest National Lab., Richland, WA (United States)

    1996-12-01T23:59:59.000Z

    Irradiation-assisted stress corrosion cracking (IASCC) is a significant materials issue for the light water reactor (LWR) industry and may also pose a problem for fusion power reactors that will use water as coolant. A new metallurgical process is proposed that involves the radiation-induced release into solution of minor impurity elements not usually thought to participate in IASCC. MnS-type precipitates, which contain most of the sulfur in stainless steels, are thought to be unstable under irradiation. First, Mn transmutes strongly to Fe in thermalized neutron spectra. Second, cascade-induced disordering and the inverse Kirkendall effect operating at the incoherent interfaces of MnS precipitates are thought to act as a pump to export Mn from the precipitate into the alloy matrix. Both of these processes will most likely allow sulfur, which is known to exert a deleterious influence on intergranular cracking, to re-enter the matrix. To test this hypothesis, compositions of MnS-type precipitates contained in several unirradiated and irradiated heats of Type 304, 316, and 348 stainless steels (SSs) were analyzed by Auger electron spectroscopy. Evidence is presented that shows a progressive compositional modification of MnS precipitates as exposure to neutrons increases in boiling water reactors. As the fluence increases, the Mn level in MnS decreases, whereas the Fe level increases. The S level also decreases relative to the combined level of Mn and Fe. MnS precipitates were also found to be a reservoir of other deleterious impurities such as F and O which could be also released due to radiation-induced instability of the precipitates.

  18. Combining Physical and Biologic Parameters to Predict Radiation-Induced Lung Toxicity in Patients With Non-Small-Cell Lung Cancer Treated With Definitive Radiation Therapy

    SciTech Connect (OSTI)

    Stenmark, Matthew H. [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Cai Xuwei [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States) [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Radiation Oncology, Shanghai Cancer Hospital, Fudan University, Shanghai (China); Shedden, Kerby [Department of Biostatistics, University of Michigan Medical Center, Ann Arbor, Michigan (United States)] [Department of Biostatistics, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Hayman, James A. [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Yuan Shuanghu [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States) [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Radiation Oncology, Shangdong Cancer Hospital, Jinan (China); Ritter, Timothy [Veterans Affairs Medical Center, Ann Arbor, Michigan (United States)] [Veterans Affairs Medical Center, Ann Arbor, Michigan (United States); Ten Haken, Randall K.; Lawrence, Theodore S. [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Kong Fengming, E-mail: fengkong@med.umich.edu [Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan (United States); Veterans Affairs Medical Center, Ann Arbor, Michigan (United States)

    2012-10-01T23:59:59.000Z

    Purpose: To investigate the plasma dynamics of 5 proinflammatory/fibrogenic cytokines, including interleukin-1beta (IL-1{beta}), IL-6, IL-8, tumor necrosis factor alpha (TNF-{alpha}), and transforming growth factor beta1 (TGF-{beta}1) to ascertain their value in predicting radiation-induced lung toxicity (RILT), both individually and in combination with physical dosimetric parameters. Methods and Materials: Treatments of patients receiving definitive conventionally fractionated radiation therapy (RT) on clinical trial for inoperable stages I-III lung cancer were prospectively evaluated. Circulating cytokine levels were measured prior to and at weeks 2 and 4 during RT. The primary endpoint was symptomatic RILT, defined as grade 2 and higher radiation pneumonitis or symptomatic pulmonary fibrosis. Minimum follow-up was 18 months. Results: Of 58 eligible patients, 10 (17.2%) patients developed RILT. Lower pretreatment IL-8 levels were significantly correlated with development of RILT, while radiation-induced elevations of TGF-ss1 were weakly correlated with RILT. Significant correlations were not found for any of the remaining 3 cytokines or for any clinical or dosimetric parameters. Using receiver operator characteristic curves for predictive risk assessment modeling, we found both individual cytokines and dosimetric parameters were poor independent predictors of RILT. However, combining IL-8, TGF-ss1, and mean lung dose into a single model yielded an improved predictive ability (P<.001) compared to either variable alone. Conclusions: Combining inflammatory cytokines with physical dosimetric factors may provide a more accurate model for RILT prediction. Future study with a larger number of cases and events is needed to validate such findings.

  19. Short CommunicationJ. Radiat. Res., 53, 475481 (2012) Triphasic Low-dose Response in Zebrafish Embryos Irradiated by

    E-Print Network [OSTI]

    Yu, K.N.

    2012-01-01T23:59:59.000Z

    the linear no-threshold (LNT) hypothesis for radiation protection considerations, which assumes that the riskShort CommunicationJ. Radiat. Res., 53, 475­481 (2012) Triphasic Low-dose Response in Zebrafish, the experimental data were in line with induc- tion of radiation-induced bystander effect as well as rescue effect

  20. Adaptive sequential controller

    DOE Patents [OSTI]

    El-Sharkawi, Mohamed A. (Renton, WA); Xing, Jian (Seattle, WA); Butler, Nicholas G. (Newberg, OR); Rodriguez, Alonso (Pasadena, CA)

    1994-01-01T23:59:59.000Z

    An adaptive sequential controller (50/50') for controlling a circuit breaker (52) or other switching device to substantially eliminate transients on a distribution line caused by closing and opening the circuit breaker. The device adaptively compensates for changes in the response time of the circuit breaker due to aging and environmental effects. A potential transformer (70) provides a reference signal corresponding to the zero crossing of the voltage waveform, and a phase shift comparator circuit (96) compares the reference signal to the time at which any transient was produced when the circuit breaker closed, producing a signal indicative of the adaptive adjustment that should be made. Similarly, in controlling the opening of the circuit breaker, a current transformer (88) provides a reference signal that is compared against the time at which any transient is detected when the circuit breaker last opened. An adaptive adjustment circuit (102) produces a compensation time that is appropriately modified to account for changes in the circuit breaker response, including the effect of ambient conditions and aging. When next opened or closed, the circuit breaker is activated at an appropriately compensated time, so that it closes when the voltage crosses zero and opens when the current crosses zero, minimizing any transients on the distribution line. Phase angle can be used to control the opening of the circuit breaker relative to the reference signal provided by the potential transformer.

  1. Adaptation Plan 

    E-Print Network [OSTI]

    Durnbaugh, A.

    2011-01-01T23:59:59.000Z

    ? Built Environment ? Natural Environment ? People FIVE STRATEGIES Copyright 2011, City of Chicago ADAPTATION ESL-KT-11-11-16 9 CCAP Adaptation Evolution 2007 2008 2009 2010 ? Understood the climate science: Assess climate impacts... E xi st in g Tr un k Existing on Rogers Rogers Ave CIP Stormwater management: Chicago?s comprehensive sewer model Climate impacts Example actions to prepare the built environment Copyright 2011, City of Chicago ESL-KT-11-11-16 13 CCAP...

  2. 7th International Workshop on Microbeam Probes of Cellular Radiation Response

    SciTech Connect (OSTI)

    Brenner, David J.

    2009-07-21T23:59:59.000Z

    The extended abstracts that follow present a summary of the Proceedings of the 7th International Workshop: Microbeam Probes of Cellular Radiation Response, held at Columbia University’s Kellogg Center in New York City on March 15–17, 2006. These International Workshops on Microbeam Probes of Cellular Radiation Response have been held regularly since 1993 (1–5). Since the first workshop, there has been a rapid growth (see Fig. 1) in the number of centers developing microbeams for radiobiological research, and worldwide there are currently about 30 microbeams in operation or under development. Single-cell/single-particle microbeam systems can deliver beams of different ionizing radiations with a spatial resolution of a few micrometers down to a few tenths of a micrometer. Microbeams can be used to addressquestions relating to the effects of low doses of radiation (a single radiation track traversing a cell or group of cells), to probe subcellular targets (e.g. nucleus or cytoplasm), and to address questions regarding the propagation of information about DNA damage (for example, the radiation-induced bystander effect). Much of the recent research using microbeams has been to study low-dose effects and ‘‘non-targeted’’ responses such as bystander effects, genomic instability and adaptive responses. This Workshop provided a forum to assess the current state of microbeam technology and current biological applications and to discuss future directions for development, both technological and biological. Over 100 participants reviewed the current state of microbeam research worldwide and reported on new technological developments in the fields of both physics and biology.

  3. Urban climate resilience : a global assessment of city adaptation plans

    E-Print Network [OSTI]

    Katich, Kristina Noel

    2009-01-01T23:59:59.000Z

    As policy makers accept climate change as an irrefutable threat, adaptation planning has emerged as a necessary action for countries, states, and municipalities. This thesis explores adaptive responses to climate change ...

  4. Adaptive Lighting

    Energy Savers [EERE]

    * ...based on environmental conditions... - Occupancy Vacancy - Daylight Availability - Demand Response Signals - ... * ...to optimize space & building performance - Maximize...

  5. Adaptation Plan

    E-Print Network [OSTI]

    Durnbaugh, A.

    2011-01-01T23:59:59.000Z

    /pest introduction. Buildings Fa?ade & structural damage. Higher peak electricity demand. Lake Michigan Decreased lake ice in winter & lower lake levels. Greater stress on water resources in times of need. Homes Increased cooling costs & energy... of Chicago ? 2011 ESL-KT-11-11-16 3 Chicago River Promote & incentivize green infrastructure to manage stormwater. Monitor threat of aquatic invasive species. RESILIENCY Adaptation will help reduce the impact of the changes that can be expected...

  6. Estimate of Radiation-Induced Steel Embrittlement in the BWR Core Shroud and Vessel Wall from Reactor-Grade MOX/UOX Fuel for the Nuclear Power Plant at Laguna Verde, Veracruz, Mexico

    SciTech Connect (OSTI)

    Vickers, Lisa R. [BWXT, U.S. Department of Energy, Pantex Plant, P.O. Box 30020, Hwy 60/FM 2373, Amarillo, TX 79120-0020 (United States)

    2002-07-01T23:59:59.000Z

    The government of Mexico has expressed interest to utilize the Laguna Verde boiling water reactor (BWR) nuclear power plant for the disposition of reprocessed spent uranium oxide (UOX) fuel in the form of reactor-grade mixed oxide (MOX) fuel. MOX fuel would replace spent UOX fuel as a fraction in the core from 18 - 30% depending on the fuel loading cycle. MOX fuel is expected to increase the neutron fluence, flux, fuel centerline temperature, reactor core pressure, and yield higher energy neutrons. There is concern that a core with a fraction of MOX fuel (i.e., increased {sup 239}Pu wt%) would increase the radiation-induced steel embrittlement within the core shroud and vessel wall as compared to only conventional, enriched UOX fuel in the core. The evaluation of radiation-induced steel embrittlement within the core shroud and vessel wall is a concern because of the potentially adverse affect to personnel and public safety, environment, and operating life of the reactor. The primary conclusion of this research was that the addition of the maximum fraction of 1/3 MOX fuel to the LV1 BWR core did significantly accelerate the radiation-induced steel embrittlement such that without mitigation of steel embrittlement by periodic thermal annealing or reduction in operating parameters such as, neutron fluence, core temperature and pressure, it posed a potentially adverse affect to the personnel and public safety, environment, and operating life of the reactor. (author)

  7. Adaptive Sampling in Hierarchical Simulation

    SciTech Connect (OSTI)

    Knap, J; Barton, N R; Hornung, R D; Arsenlis, A; Becker, R; Jefferson, D R

    2007-07-09T23:59:59.000Z

    We propose an adaptive sampling methodology for hierarchical multi-scale simulation. The method utilizes a moving kriging interpolation to significantly reduce the number of evaluations of finer-scale response functions to provide essential constitutive information to a coarser-scale simulation model. The underlying interpolation scheme is unstructured and adaptive to handle the transient nature of a simulation. To handle the dynamic construction and searching of a potentially large set of finer-scale response data, we employ a dynamic metric tree database. We study the performance of our adaptive sampling methodology for a two-level multi-scale model involving a coarse-scale finite element simulation and a finer-scale crystal plasticity based constitutive law.

  8. Hyperbaric Oxygen Treatment in Radiation-Induced Cystitis and Proctitis: A Prospective Cohort Study on Patient-Perceived Quality of Recovery

    SciTech Connect (OSTI)

    Oscarsson, Nicklas, E-mail: nicklas.oscarsson@vgregion.se [Department of Anaesthesiology and Intensive Care Medicine, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg (Sweden); Arnell, Per [Department of Anaesthesiology and Intensive Care Medicine, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg (Sweden); Lodding, Pär [Department of Urology, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg (Sweden); Ricksten, Sven-Erik; Seeman-Lodding, Heléne [Department of Anaesthesiology and Intensive Care Medicine, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg (Sweden)

    2013-11-15T23:59:59.000Z

    Purpose: In this prospective cohort study, the effects of hyperbaric oxygen treatment (HBOT) were evaluated concerning patient-perceived symptoms of late radiation-induced cystitis and proctitis secondary to radiation therapy for pelvic cancer. Methods and Materials: Thirty-nine patients, 35 men and 4 women with a mean age of 71 (range, 35-84) years were included after informed consent and institutional ethics approval. They had all been treated with radiation therapy for prostate (n=34), cervix (n=2), or rectal (n=3) cancer using external beam radiation at a dose of 25 to 75 Gy. Patients with hematuria requiring blood transfusion were excluded. The HBOT was delivered with 100% oxygen for 90 minutes at 2.0 to 2.4 atmospheres (ATA). Mean number of treatments was 36 (28-40). Symptoms were prospectively assessed using the Expanded Prostate Index Composite score before, during, and 6 to 12 months after HBOT. Results: The HBOT was successfully conducted, and symptoms were alleviated in 76% for patients with radiation cystitis, 89% for patients with radiation proctitis, and 88% of patients with combined cystitis and proctitis. Symptom reduction was demonstrated by an increased Expanded Prostate Index Composite score in the urinary domain from 50 ± 16 to 66 ± 20 after treatment (P<.001) and in the bowel domain from 48 ± 18 to 68 ± 18 after treatment (P<.001). For 31% of the patients with cystitis and 22% with proctitis, there were only trivial symptoms after HBOT. The improvement was sustained at follow-up in both domains 6 to 12 months after HBOT. No severe side effects were observed related to HBOT, and treatment compliance was high. Conclusions: HBOT can be an effective and safe treatment modality for late radiation therapy-induced soft tissue injuries in the pelvic region.

  9. Analysis of Vision Loss Caused by Radiation-Induced Optic Neuropathy After Particle Therapy for Head-and-Neck and Skull-Base Tumors Adjacent to Optic Nerves

    SciTech Connect (OSTI)

    Demizu, Yusuke, E-mail: y_demizu@nifty.co [Department of Radiology, Hyogo Ion Beam Medical Center, Tatsuno, Hyogo (Japan); Murakami, Masao; Miyawaki, Daisuke; Niwa, Yasue [Department of Radiology, Hyogo Ion Beam Medical Center, Tatsuno, Hyogo (Japan); Akagi, Takashi [Department of Accelerator Managing, Hyogo Ion Beam Medical Center, Tatsuno, Hyogo (Japan); Sasaki, Ryohei [Division of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Terashima, Kazuki [Department of Radiology, Hyogo Ion Beam Medical Center, Tatsuno, Hyogo (Japan); Suga, Daisaku [Department of Radiation Technology, Hyogo Ion Beam Medical Center, Tatsuno, Hyogo (Japan); Kamae, Isao [Division of Medical Statistics, Kobe University Graduate School of Medicine, Kobe, Hyogo (Japan); Hishikawa, Yoshio [Department of Radiology, Hyogo Ion Beam Medical Center, Tatsuno, Hyogo (Japan)

    2009-12-01T23:59:59.000Z

    Purpose: To assess the incident rates of vision loss (VL; based on counting fingers or more severe) caused by radiation-induced optic neuropathy (RION) after particle therapy for tumors adjacent to optic nerves (ONs), and to evaluate factors that may contribute to VL. Methods and Materials: From August 2001 to August 2006, 104 patients with head-and-neck or skull-base tumors adjacent to ONs were treated with carbon ion or proton radiotherapy. Among them, 145 ONs of 75 patients were irradiated and followed for greater than 12 months. The incident rate of VL and the prognostic factors for occurrence of VL were evaluated. The late effects of carbon ion and proton beams were compared on the basis of a biologically effective dose at alpha/beta = 3 gray equivalent (GyE{sub 3}). Results: Eight patients (11%) experienced VL resulting from RION. The onset of VL ranged from 17 to 58 months. The median follow-up was 25 months. No significant difference was observed between the carbon ion and proton beam treatment groups. On univariate analysis, age (>60 years), diabetes mellitus, and maximum dose to the ON (>110 GyE{sub 3}) were significant, whereas on multivariate analysis only diabetes mellitus was found to be significant for VL. Conclusions: The time to the onset of VL was highly variable. There was no statistically significant difference between carbon ion and proton beam treatments over the follow-up period. Based on multivariate analysis, diabetes mellitus correlated with the occurrence of VL. A larger study with longer follow-up is warranted.

  10. Post Treatment With an FGF Chimeric Growth Factor Enhances Epithelial Cell Proliferation to Improve Recovery From Radiation-Induced Intestinal Damage

    SciTech Connect (OSTI)

    Nakayama, Fumiaki, E-mail: f_naka@nirs.go.j [Department of Radiation Emergency Medicine, National Institute of Radiological Sciences, Chiba (Japan); Hagiwara, Akiko; Umeda, Sachiko [Department of Radiation Emergency Medicine, National Institute of Radiological Sciences, Chiba (Japan); Asada, Masahiro; Goto, Megumi; Oki, Junko; Suzuki, Masashi; Imamura, Toru [Signaling Molecules Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba (Japan); Akashi, Makoto [Department of Radiation Emergency Medicine, National Institute of Radiological Sciences, Chiba (Japan)

    2010-11-01T23:59:59.000Z

    Purpose: A fibroblast growth factor (FGF) 1-FGF2 chimera (FGFC) was created previously and showed greater structural stability than FGF1. This chimera was capable of stimulating epithelial cell proliferation much more strongly than FGF1 or FGF2 even without heparin. Therefore FGFC was expected to have greater biologic activity in vivo. This study evaluated and compared the protective activity of FGFC and FGF1 against radiation-induced intestinal injuries. Methods and Materials: We administered FGFC and FGF1 intraperitoneally to BALB/c mice 24 h before or after total-body irradiation (TBI). The numbers of surviving crypts were determined 3.5 days after TBI with gamma rays at doses ranging from 8 to 12 Gy. Results: The effect of FGFC was equal to or slightly superior to FGF1 with heparin. However, FGFC was significantly more effective in promoting crypt survival than FGF1 (p < 0.01) when 10 {mu}g of each FGF was administered without heparin before irradiation. In addition, FGFC was significantly more effective at promoting crypt survival (p < 0.05) than FGF1 even when administered without heparin at 24 h after TBI at 10, 11, or 12 Gy. We found that FGFC post treatment significantly promoted 5-bromo-2'-deoxyuridine incorporation into crypts and increased crypt depth, resulting in more epithelial differentiation. However, the number of apoptotic cells in FGFC-treated mice decreased to almost the same level as that in FGF1-treated mice. Conclusions: These findings suggest that FGFC strongly enhanced radioprotection with the induction of epithelial proliferation without exogenous heparin after irradiation and is useful in clinical applications for both the prevention and post treatment of radiation injuries.

  11. SNP in TXNRD2 Associated With Radiation-Induced Fibrosis: A Study of Genetic Variation in Reactive Oxygen Species Metabolism and Signaling

    SciTech Connect (OSTI)

    Edvardsen, Hege, E-mail: hege.edvardsen@rr-research.no [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway) [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway); K. G. Jebsen Breast cancer centre, Institute for Clinical Medicine, University of Oslo, Oslo (Norway); Landmark-Høyvik, Hege [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway) [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway); K. G. Jebsen Breast cancer centre, Institute for Clinical Medicine, University of Oslo, Oslo (Norway); Reinertsen, Kristin V. [National Resource Centre for Late Effects after Cancer Treatment, OUS Radiumhospitalet, Oslo (Norway)] [National Resource Centre for Late Effects after Cancer Treatment, OUS Radiumhospitalet, Oslo (Norway); Zhao, Xi [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway) [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway); K. G. Jebsen Breast cancer centre, Institute for Clinical Medicine, University of Oslo, Oslo (Norway); Grenaker-Alnæs, Grethe Irene; Nebdal, Daniel [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway)] [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway); Syvänen, Ann-Christine [Department of Medical Sciences, Uppsala University, Uppsala (Sweden)] [Department of Medical Sciences, Uppsala University, Uppsala (Sweden); Rødningen, Olaug [Department of Medical Genetics, OUS Ullevaal, Oslo (Norway)] [Department of Medical Genetics, OUS Ullevaal, Oslo (Norway); Alsner, Jan; Overgaard, Jens [Department of Experimental Clinical Oncology, Ahus University Hospital (Norway)] [Department of Experimental Clinical Oncology, Ahus University Hospital (Norway); Borresen-Dale, Anne-Lise [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway) [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway); K. G. Jebsen Breast cancer centre, Institute for Clinical Medicine, University of Oslo, Oslo (Norway); Fosså, Sophie D. [K. G. Jebsen Breast cancer centre, Institute for Clinical Medicine, University of Oslo, Oslo (Norway) [K. G. Jebsen Breast cancer centre, Institute for Clinical Medicine, University of Oslo, Oslo (Norway); National Resource Centre for Late Effects after Cancer Treatment, OUS Radiumhospitalet, Oslo (Norway); Kristensen, Vessela N. [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway) [Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Oslo (Norway); K. G. Jebsen Breast cancer centre, Institute for Clinical Medicine, University of Oslo, Oslo (Norway); Department of Clinical Molecular Biology (EpiGen), Division of Medicine, Ahus University Hospital (Norway)

    2013-07-15T23:59:59.000Z

    Purpose: The aim of the study was to identify noninvasive markers of treatment-induced side effects. Reactive oxygen species (ROS) are generated after irradiation, and genetic variation in genes related to ROS metabolism might influence the level of radiation-induced adverse effects (AEs). Methods and Materials: 92 breast cancer (BC) survivors previously treated with hypofractionated radiation therapy were assessed for the AEs subcutaneous atrophy and fibrosis, costal fractures, lung fibrosis, pleural thickening, and telangiectasias (median follow-up time 17.1 years). Single-nucleotide polymorphisms (SNPs) in 203 genes were analyzed for association to AE grade. SNPs associated with subcutaneous fibrosis were validated in an independent BC survivor material (n=283). The influence of the studied genetic variation on messenger ribonucleic acid (mRNA) expression level of 18 genes previously associated with fibrosis was assessed in fibroblast cell lines from BC patients. Results: Subcutaneous fibrosis and atrophy had the highest correlation (r=0.76) of all assessed AEs. The nonsynonymous SNP rs1139793 in TXNRD2 was associated with grade of subcutaneous fibrosis, the reference T-allele being more prevalent in the group experiencing severe levels of fibrosis. This was confirmed in another sample cohort of 283 BC survivors, and rs1139793 was found significantly associated with mRNA expression level of TXNRD2 in blood. Genetic variation in 24 ROS-related genes, including EGFR, CENPE, APEX1, and GSTP1, was associated with mRNA expression of 14 genes previously linked to fibrosis (P?.005). Conclusion: Development of subcutaneous fibrosis can be associated with genetic variation in the mitochondrial enzyme TXNRD2, critically involved in removal of ROS, and maintenance of the intracellular redox balance.

  12. Silver Clear Nylon Dressing is Effective in Preventing Radiation-Induced Dermatitis in Patients With Lower Gastrointestinal Cancer: Results From a Phase III Study

    SciTech Connect (OSTI)

    Niazi, Tamim M. [Segal Cancer Centre, Department of Radiation Oncology, Jewish General Hospital, McGill University (Canada)] [Segal Cancer Centre, Department of Radiation Oncology, Jewish General Hospital, McGill University (Canada); Vuong, Te, E-mail: tvuong@jgh.mcgill.ca [Segal Cancer Centre, Department of Radiation Oncology, Jewish General Hospital, McGill University (Canada)] [Segal Cancer Centre, Department of Radiation Oncology, Jewish General Hospital, McGill University (Canada); Azoulay, Laurant [Department of Epidemiology, Jewish General Hospital, McGill University (Canada)] [Department of Epidemiology, Jewish General Hospital, McGill University (Canada); Marijnen, Corrie [Department of Clinical Oncology, Leiden University Medical Center, Amsterdam (Netherlands)] [Department of Clinical Oncology, Leiden University Medical Center, Amsterdam (Netherlands); Bujko, Kryzstof [Department of Radiotherapy, The Maria Sklodowska-Curie Memorial Cancer Centre, Warsaw (Poland)] [Department of Radiotherapy, The Maria Sklodowska-Curie Memorial Cancer Centre, Warsaw (Poland); Nasr, Elie [Department of Radiation Oncology, Hotel-Dieu de France Hospital (Lebanon)] [Department of Radiation Oncology, Hotel-Dieu de France Hospital (Lebanon); Lambert, Christine; Duclos, Marie; Faria, Sergio; David, Marc [Department of Radiation Oncology, Montreal-General-Hospital, McGill University, Montreal (Canada)] [Department of Radiation Oncology, Montreal-General-Hospital, McGill University, Montreal (Canada); Cummings, Bernard [Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto (Canada)] [Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto (Canada)

    2012-11-01T23:59:59.000Z

    Purpose: For patients with anal canal and advanced rectal cancer, chemoradiation therapy is a curative modality or an important adjunct to surgery. Nearly all patients treated with chemoradiation experience some degree of radiation-induced dermatitis (RID). Prevention and effective treatment of RID, therefore, is of considerable clinical relevance. The present phase III randomized trial compared the efficacy of silver clear nylon dressing (SCND) with that of standard skin care for these patients. Methods and Materials: A total of 42 rectal or anal canal cancer patients were randomized to either a SCND or standard skin care group. SCND was applied from Day 1 of radiation therapy (RT) until 2 weeks after treatment completion. In the control arm, sulfadiazine cream was applied at the time of skin dermatitis. Printed digital photographs taken 2 weeks prior to, on the last day, and two weeks after the treatment completion were scored by 10 blinded readers, who used the common toxicity scoring system for skin dermatitis. Results: The radiation dose ranged from 50.4 to 59.4 Gy, and there were no differences between the 2 groups. On the last day of RT, when the most severe RID occurs, the mean dermatitis score was 2.53 (standard deviation [SD], 1.17) for the standard and 1.67 (SD, 1.2; P=.01) for the SCND arm. At 2 weeks after RT, the difference was 0.39 points in favor of SCND (P=.39). There was considerable intraclass correlation among the 10 observers. Conclusions: Silver clear nylon dressing is effective in reducing RID in patients with lower gastrointestinal cancer treated with combined chemotherapy and radiation treatment.

  13. Multi-model adaptive spatial hypertext 

    E-Print Network [OSTI]

    Francisco-Revilla, Luis

    2005-02-17T23:59:59.000Z

    in response to multiple relevant factors. The framework is composed of four parts: a general system architecture, a definition of the fundamental concepts in spatial hypermedia, an ontological classification of the adaptation strategies, and the philosophy...

  14. Skeletal adaptation to reduced mechanical loading

    E-Print Network [OSTI]

    Eliman, Rachel

    2014-01-01T23:59:59.000Z

    Bone adapts its mass and architecture in response to its mechanical environment. Yet control of this process by mechanical cues is poorly understood, particularly for unloading. Defining the fundamental mechanoregulation ...

  15. Synthesis and Application of an Environmentally Insensitive Cy3-Based Arsenical Fluorescent Probe to Identify Adaptive Microbial Responses Involving Proximal Dithiol Oxidation

    SciTech Connect (OSTI)

    Fu, Na; Su, Dian; Cort, John R.; Chen, Baowei; Xiong, Yijia; Qian, Weijun; Konopka, Allan; Bigelow, Diana J.; Squier, Thomas C.

    2013-03-06T23:59:59.000Z

    Reversible disulfide oxidation between proximal cysteines in proteins represents a common regulatory control mechanism to modulate flux through metabolic pathways in response to changing environmental conditions. To enable in vivo measurements of cellular redox changes linked to disulfide bond formation, we have synthesized a cell-permeable monosubstituted cyanine dye derivatized with arsenic (i.e., TRAP_Cy3) to trap and visualize dithiols in cytosolic proteins. Alkylation of reactive thiols prior to displacement of the bound TRAP-Cy3 by ethanedithiol permits facile protein capture and mass spectrometric identification of proximal reduced dithiols to the exclusion of individual cysteines. Applying TRAP_Cy3 to evaluate cellular responses to increases in oxygen and light levels in the photosynthetic microbe Synechococcus sp. PCC 7002, we observe large decreases in the abundance of reduced dithiols in cellular proteins, which suggest redox-dependent mechanisms involving the oxidation of proximal disulfides. Under these same growth conditions that result in the oxidation of proximal thiols, there is a reduction in the abundance of post-translational oxidative modifications involving nitrotyrosine and methionine sulfoxide formation. These results suggest that the redox status of proximal cysteines respond to environmental conditions, acting to regulate metabolic flux and minimize the formation of reactive oxygen species to decrease oxidative protein damage.

  16. Model Driven Mutation Applied to Adaptative Systems Testing

    E-Print Network [OSTI]

    Bartel, Alexandre; Munoz, Freddy; Klein, Jacques; Mouelhi, Tejeddine; Traon, Yves Le

    2012-01-01T23:59:59.000Z

    Dynamically Adaptive Systems modify their behav- ior and structure in response to changes in their surrounding environment and according to an adaptation logic. Critical sys- tems increasingly incorporate dynamic adaptation capabilities; examples include disaster relief and space exploration systems. In this paper, we focus on mutation testing of the adaptation logic. We propose a fault model for adaptation logics that classifies faults into environmental completeness and adaptation correct- ness. Since there are several adaptation logic languages relying on the same underlying concepts, the fault model is expressed independently from specific adaptation languages. Taking benefit from model-driven engineering technology, we express these common concepts in a metamodel and define the operational semantics of mutation operators at this level. Mutation is applied on model elements and model transformations are used to propagate these changes to a given adaptation policy in the chosen formalism. Preliminary resul...

  17. Sensor response rate accelerator

    DOE Patents [OSTI]

    Vogt, Michael C. (Westmont, IL)

    2002-01-01T23:59:59.000Z

    An apparatus and method for sensor signal prediction and for improving sensor signal response time, is disclosed. An adaptive filter or an artificial neural network is utilized to provide predictive sensor signal output and is further used to reduce sensor response time delay.

  18. A Computational Model for Adaptive Emotion Regulation

    E-Print Network [OSTI]

    Treur, Jan

    A Computational Model for Adaptive Emotion Regulation Tibor Bosse, Matthijs Pontier, and Jan Treur} Abstract. Emotion regulation describes how a subject can use certain strategies to affect emotion response levels. Usually, models for emotion regulation as- sume mechanisms based on feedback loops that indicate

  19. SU-E-J-190: Characterization of Radiation Induced CT Number Changes in Tumor and Normal Lung During Radiation Therapy for Lung Cancer

    SciTech Connect (OSTI)

    Yang, C; Liu, F; Tai, A; Gore, E; Johnstone, C; Li, X [Medical College of Wisconsin Milwaukee WI (United States)

    2014-06-01T23:59:59.000Z

    Purpose: To measure CT number (CTN) changes in tumor and normal lung as a function of radiation therapy (RT) dose during the course of RT delivery for lung cancer using daily IGRT CT images and single respiration phase CT images. Methods: 4D CT acquired during planning simulation and daily 3D CT acquired during daily IGRT for 10 lung cancer cases randomly selected in terms of age, caner type and stage, were analyzed using an in-house developed software tool. All patients were treated in 2 Gy fractions to primary tumors and involved nodal regions. Regions enclosed by a series of isodose surfaces in normal lung were delineated. The obtained contours along with target contours (GTVs) were populated to each singlephase planning CT and daily CT. CTN in term of Hounsfield Unit (HU) of each voxel in these delineated regions were collectively analyzed using histogram, mean, mode and linear correlation. Results: Respiration induced normal lung CTN change, as analyzed from single-phase planning CTs, ranged from 9 to 23 (±2) HU for the patients studied. Normal lung CTN change was as large as 50 (±12) HU over the entire treatment course, was dose and patient dependent and was measurable with dose changes as low as 1.5 Gy. For patients with obvious tumor volume regression, CTN within the GTV drops monotonically as much as 10 (±1) HU during the early fractions with a total dose of 20 Gy delivered. The GTV and CTN reductions are significantly correlated with correlation coefficient >0.95. Conclusion: Significant RT dose induced CTN changes in lung tissue and tumor region can be observed during even the early phase of RT delivery, and may potentially be used for early prediction of radiation response. Single respiration phase CT images have dramatically reduced statistical noise in ROIs, making daily dose response evaluation possible.

  20. Adaptive protocols for mobile ad hoc networks

    E-Print Network [OSTI]

    Holland, Gavin Douglas

    2005-02-17T23:59:59.000Z

    . We investigate new link layer mechanisms that dynamically monitor and adapt to changes in link quality, including a protocol that uses common control messages to form a tight feedback control loop for adaptation of the link data rate to best match... of the presence of multirate links. We then investigate the performance of iv TCP, showing how communication outages caused by link failures and routing delays can be very detrimental to its performance. In response, we present a solution to this problem that uses...

  1. Nuclear apoJ: A low dose radiation inducible regulator of cell death. Final report for period September 15, 1998 - September 14, 2001

    SciTech Connect (OSTI)

    Aronow, Bruce J.

    2002-04-19T23:59:59.000Z

    This project was based on preliminary data that was published by Dr. Boothman (Yang et al. 2000) which indicated a strong induction of apoJ gene expression, increased secretion of the protein, and accumulation of an apparently somewhat different form of the apoJ protein in the nucleus of MCF-7 breast carcinoma cells undergoing response to DNA damage. A clone expressing apoJ protein was isolated that was capable of interacting with Ku80, a component of the double strand break repair complex that is essential for the successful repair of rearranging immunoglobulin and T-cell receptor genes as evidenced by failure to produce mature B and T cells in the absence of Ku70. ApoJ clones isolated and characterized by Dr. Boothman bound strongly to a Ku-70 ''bait'' protein. Over-expression of these same clones in a cell line was capable of killing the cell. ApoJ is very strongly induced in many instances of programmed cell death and has been proposed repeatedly to play some sort of effector role in the process. Our principle hypothesis for this study was that the strong induction of the apoJ gene and the particular expression of a nuclear form of the protein was potentially a causal factor in the decision point made by the cell as it attempts to repair double-strand breakage based DNA damage. The hypothesis was that if sufficiently high damage occurred, it would be deleterious to maintain the cell's viability through continued DNA repair. One method to inhibit DNA repair might be by inhibiting proteins such as Ku-70 that are necessary for double-strand break repair. If apoJ does play a critical role in tipping the decision balance over to cell death, we reasoned that deficiency of apoJ would cause increased accumulation of cells with DNA damage and that this might decrease cell death in response to DNA damage and increase tumor occurrence rates. To test this hypothesis and its potential implications, we exposed wildtype and apoJ deficient animals that we constructed through gene targeting to increasing levels of ionizing radiation from a Cesium source. Data gathered under the support of this grant application initially indicated that apoJ deficient animals were more resistant to radiation, but as we accumulated more and more data points and covered a tighter exposure range, the genotype-based differences became insignificant. However, the possibility existed that because mortality based radiation-resistance could be attributable to mechanism for which nuclear apoJ was not rate determining, we maintained a very large of colony of apoJ knockout and wildtype animals in both the C57/B16 and Cv129 strain backgrounds that were exposed to sub-lethal levels of ionizing radiation to monitor for the occurrence of tumors. These animals were allowed to fully recover and age normally in either germ free or normal animal housing. Our results demonstrated no significant differences between wildtype and apoJ knockout animals over a period that extended up to 30 months for individual animals. We recorded similar weight gain, a relatively low mortality rate, and a similar mixture and rate of sarcoma and adenocarcinomas after surviving the initial ionizing radiation exposures. Thus we conclude that apoJ gene function, which was totally eliminated by our gene targeting, did not influence radiation sensitivity or serve as a tumor suppressor in response to DNA damage.

  2. Adaptive Street Lighting Controls

    Broader source: Energy.gov [DOE]

    This two-part DOE Municipal Solid-State Street Lighting Consortium webinar focused on LED street lighting equipped with adaptive control components. In Part I, presenters Amy Olay of the City of...

  3. Climate Change Adaptation Planning

    Office of Energy Efficiency and Renewable Energy (EERE)

    This course provides an introduction to planning for climate change impacts, with examples of tribes that have been going through the adaptation planning process. The course is intended for tribal...

  4. Discriminative Adaptive Training and Bayesian Inference for

    E-Print Network [OSTI]

    de Gispert, Adrià

    adaptation is a standard part of many speech recognition systems. This process requires some adaptation data

  5. Organizational Adaptation Kathleen M. Carley

    E-Print Network [OSTI]

    Sadeh, Norman M.

    Organizational Adaptation Kathleen M. Carley Dept. of Social and Decision Sciences Carnegie Mellon: Kathleen M. Carley, 1998, "Organizational Adaptation." Annals of Operations Research. 75: 25-47. #12;Organizational Adaptation A computational model of organizational adaptation in which change occurs at both

  6. Lymphatic Functional Adaptations to Prolonged Changes in Mechanical Stimuli

    E-Print Network [OSTI]

    Nguyen, Tam L

    2013-03-21T23:59:59.000Z

    ). The adaptive responses first reported in the present work, are thus consistent with an accepted understanding of interstitial volume regulation (4). 3.1.3b. Strengths of the experimental model The difficulty in studying adaptation of blood vessels..., one end of a fluid-filled tube (Tygon R3603, Saint- Gobain Performance Plastic, Garden Grove, CA) was inserted through the wall of the vein while the other end was brought outside of the animal. Exteriorized intestine and mesentery were...

  7. Adaptive Medical Information Delivery Combining User, Task and Situation Models

    E-Print Network [OSTI]

    ., in their model for adaptive hypermedia AHAM [2], distinguish content­adaptation from link­ adaptation

  8. Mitigation of radiation induced surface contamination

    DOE Patents [OSTI]

    Klebanoff, Leonard E. (Dublin, CA); Stulen, Richard H. (Livermore, CA)

    2003-01-01T23:59:59.000Z

    A process for mitigating or eliminating contamination and/or degradation of surfaces having common, adventitious atmospheric contaminants adsorbed thereon and exposed to radiation. A gas or a mixture of gases is introduced into the environment of a surface(s) to be protected. The choice of the gaseous species to be introduced (typically a hydrocarbon gas, water vapor, or oxygen or mixtures thereof) is dependent upon the contaminant as well as the ability of the gaseous species to bind to the surface to be protected. When the surface and associated bound species are exposed to radiation reactive species are formed that react with surface contaminants such as carbon or oxide films to form volatile products (e.g., CO, CO.sub.2) which desorb from the surface.

  9. Radiation Induced Nanocrystal Formation in Metallic Glasses 

    E-Print Network [OSTI]

    Carter, Jesse

    2010-01-14T23:59:59.000Z

    simple system consisting of only two elements, several intermetallic compounds can exist, each with their own crystal structure (face-centered cubic, body-centered, etc), and the system gets much more complicated when the number of constituents... of Alloys and Compounds, Vol 431, Q.S. Zhang, W. Zhang, G.Q. Xie, K.S. Nakayama, H. Kimura and A. Inoue, Formation of bulk metallic glass in situ composites in Cu50Zr45Ti5 alloy, Pages 236-240, Copyright 2007, with permission from Elsevier. 16 Fig. 9...

  10. Radiation Induced Nanocrystal Formation in Metallic Glasses

    E-Print Network [OSTI]

    Carter, Jesse

    2010-01-14T23:59:59.000Z

    The irradiation of metallic glasses to induce nanocrystallization was studied in two metallic glass compositions, Cu50Zr45Ti5 and Zr55Cu30Al10Ni5. Atomic mobility was described using a model based on localized excess free volume due to displace...

  11. CONTRIBUTED Adaptive Stochastic Control

    E-Print Network [OSTI]

    Powell, Warren B.

    sources, many forms of energy storage, and microgrid management (see Fig. 1). Computationally, controlling of distributed generation and storage within the Smart Grid. KEYWORDS | Adaptive stochastic control (ASC.g., factory assembly lines, petrochemical plants, and nuclear power plants). Below we describe

  12. Energy dissipation in an adaptive molecular circuit

    E-Print Network [OSTI]

    Shou-Wen Wang; Yueheng Lan; Lei-Han Tang

    2015-05-28T23:59:59.000Z

    The ability to monitor nutrient and other environmental conditions with high sensitivity is crucial for cell growth and survival. Sensory adaptation allows a cell to recover its sensitivity after a transient response to a shift in the strength of extracellular stimulus. The working principles of adaptation have been established previously based on rate equations which do not consider fluctuations in a thermal environment. Recently, G. Lan et al. (Nature Phys., 8:422-8, 2012) performed a detailed analysis of a stochastic model for the E. coli sensory network. They showed that accurate adaptation is possible only when the system operates in a nonequilibrium steady-state (NESS). They further proposed an energy-speed-accuracy (ESA) trade-off relation. We present here analytic results on the NESS of the model through a mapping to a one-dimensional birth-death process. An exact expression for the entropy production rate is also derived. Based on these results, we are able to discuss the ESA relation in a more general setting. Our study suggests that the adaptation error can be reduced exponentially as the methylation range increases. Finally, we show that a nonequilibrium phase transition exists in the infinite methylation range limit, despite the fact that the model contains only two discrete variables.

  13. ON AN ADAPTIVE CONTROL ALGORITHM FOR ADAPTIVE OPTICS APPLICATIONS

    E-Print Network [OSTI]

    ON AN ADAPTIVE CONTROL ALGORITHM FOR ADAPTIVE OPTICS APPLICATIONS MOODY T. CHU Abstract. The wavefront aberrations induced by atmospheric turbulence can severely degrade the performance of an optical imaging system. Adaptive optics refers to the process of removing unwanted wave front distortions

  14. ON AN ADAPTIVE CONTROL ALGORITHM FOR ADAPTIVE OPTICS APPLICATIONS

    E-Print Network [OSTI]

    ON AN ADAPTIVE CONTROL ALGORITHM FOR ADAPTIVE OPTICS APPLICATIONS MOODY T. CHU \\Lambda Abstract. The wavefront aberrations induced by atmospheric turbulence can severely degrade the performance of an optical imaging system. Adaptive optics refers to the process of removing unwanted wave front distortions

  15. Climate Change, Adaptation, and Development

    E-Print Network [OSTI]

    Cole, Daniel H.

    2008-01-01T23:59:59.000Z

    Climate Change, Adaptation, and Development Daniel H. Cole*THE COSTS OF CLIMATE CHANGE . ADAPTATIONCONVENTION ON CLIMATE CHANGE . IV. A.

  16. Transforming Growth Factor ?-1 (TGF-?1) Is a Serum Biomarker of Radiation Induced Fibrosis in Patients Treated With Intracavitary Accelerated Partial Breast Irradiation: Preliminary Results of a Prospective Study

    SciTech Connect (OSTI)

    Boothe, Dustin L. [Weill Cornell Medical College of Cornell University, New York, New York (United States); Coplowitz, Shana [Department of Radiation Oncology, Stich Radiation Center, Weill Cornell Medical College of Cornell University, New York, New York (United States); Greenwood, Eleni [Weill Cornell Medical College of Cornell University, New York, New York (United States); Barney, Christian L. [Department of Radiation Oncology, Ohio State University, Columbus, Ohio (United States); Christos, Paul J. [Division of Biostatistics and Epidemiology, Department of Public Health, Weill Cornell Medical College of Cornell University, New York, New York (United States); Parashar, Bhupesh; Nori, Dattatreyudu; Chao, K. S. Clifford [Department of Radiation Oncology, Stich Radiation Center, Weill Cornell Medical College of Cornell University, New York, New York (United States); Wernicke, A. Gabriella, E-mail: gaw9008@med.cornell.edu [Department of Radiation Oncology, Stich Radiation Center, Weill Cornell Medical College of Cornell University, New York, New York (United States)

    2013-12-01T23:59:59.000Z

    Purpose: To examine a relationship between serum transforming growth factor ? -1 (TGF-?1) values and radiation-induced fibrosis (RIF). Methods and Materials: We conducted a prospective analysis of the development of RIF in 39 women with American Joint Committee on Cancer stage 0-I breast cancer treated with lumpectomy and accelerated partial breast irradiation via intracavitary brachytherapy (IBAPBI). An enzyme-linked immunoassay (Quantikine, R and D, Minneapolis, MN) was used to measure serum TGF-?1 before surgery, before IBAPBI, and during IBAPBI. Blood samples for TGF-?1 were also collected from 15 healthy, nontreated women (controls). The previously validated tissue compliance meter (TCM) was used to objectively assess RIF. Results: The median time to follow-up for 39 patients was 44 months (range, 5-59 months). RIF was graded by the TCM scale as 0, 1, 2, and 3 in 5 of 20 patients (25%), 6 of 20 patients (30%), 5 of 20 patients (25%), and 4 of 20 patients (20%), respectively. The mean serum TGF-?1 values were significantly higher in patients before surgery than in disease-free controls, as follows: all cancer patients (30,201 ± 5889 pg/mL, P=.02); patients with any type of RIF (32,273 ± 5016 pg/mL, P<.0001); and women with moderate to severe RIF (34,462 ± 4713 pg/mL, P<0.0001). Patients with moderate to severe RIF had significantly elevated TGF-?1 levels when compared with those with none to mild RIF before surgery (P=.0014) during IBAPBI (P?0001), and the elevation persisted at 6 months (P?.001), 12 months (P?.001), 18 months (P?.001), and 24 months (P=.12). A receiver operating characteristic (ROC) curve of TGF-?1 values predicting moderate to severe RIF was generated with an area under the curve (AUC){sub ROC} of 0.867 (95% confidence interval 0.700-1.000). The TGF-?1 threshold cutoff was determined to be 31,000 pg/mL, with associated sensitivity and specificity of 77.8% and 90.0%, respectively. Conclusions: TGF-?1 levels correlate with the development of moderate to severe RIF. The pre-IBAPBI mean TGF-?1 levels can serve as an early biomarker for the development of moderate to severe RIF after IBAPBI.

  17. ON ADAPTIVE SAMPLING Philippe Flajolet

    E-Print Network [OSTI]

    Flajolet, Philippe

    . We analyze the storage/accuracy trade--off of an adaptive sampling algorithm due to Wegman that makes. Wegman [11] has proposed an interesting alternative solution to that problem based on Adaptive Sampling 4. 2 Wegman's Adaptive Sampling Method The problem discussed here is the following. We are given

  18. Adaptive control for accelerators

    DOE Patents [OSTI]

    Eaton, Lawrie E. (Los Alamos, NM); Jachim, Stephen P. (Los Alamos, NM); Natter, Eckard F. (Santa Fe, NM)

    1991-01-01T23:59:59.000Z

    An adaptive feedforward control loop is provided to stabilize accelerator beam loading of the radio frequency field in an accelerator cavity during successive pulses of the beam into the cavity. A digital signal processor enables an adaptive algorithm to generate a feedforward error correcting signal functionally determined by the feedback error obtained by a beam pulse loading the cavity after the previous correcting signal was applied to the cavity. Each cavity feedforward correcting signal is successively stored in the digital processor and modified by the feedback error resulting from its application to generate the next feedforward error correcting signal. A feedforward error correcting signal is generated by the digital processor in advance of the beam pulse to enable a composite correcting signal and the beam pulse to arrive concurrently at the cavity.

  19. An Extensible, Lightweight Architecture for Adaptive J2EE Applications

    SciTech Connect (OSTI)

    Gorton, Ian; Liu, Yan; Trivedi, Nihar

    2006-11-01T23:59:59.000Z

    Server applications with adaptive behaviors can adapt their functionality in response to environmental changes, and significantly reduce the on-going costs of system deployment and administration. However, developing adaptive server applications is challenging due to the complexity of server technologies and highly dynamic application environments. This paper presents an architecture framework, known as the Adaptive Server Framework (ASF). ASF provides a clear separation between the implementation of adaptive behaviors and the server application business logic. This means a server application can be cost effectively extended with programmable adaptive features through the definition and implementation of control components defined in ASF. Further-more, ASF is a lightweight architecture in that it incurs low CPU overhead and memory usage. We demonstrate the effectiveness of ASF through a case study, in which a server application dynamically determines the resolution and quality to scale an image based on the load of the server and network connection speed. The experimental evaluation demonstrates the performance gains possible by adaptive behaviors and the low overhead introduced by ASF.

  20. Rendering Adaptation to Address Communication and Computation Constraints in Cloud Mobile Gaming

    E-Print Network [OSTI]

    California at San Diego, University of

    Rendering Adaptation to Address Communication and Computation Constraints in Cloud Mobile Gaming the responsibility of executing the gaming engines, including the most compute intensive tasks of graphic rendering imposed by the cost and availability of cloud servers. In this paper, we propose a rendering adaptation

  1. Demand Response for Ancillary Services

    SciTech Connect (OSTI)

    Alkadi, Nasr E [ORNL; Starke, Michael R [ORNL

    2013-01-01T23:59:59.000Z

    Many demand response resources are technically capable of providing ancillary services. In some cases, they can provide superior response to generators, as the curtailment of load is typically much faster than ramping thermal and hydropower plants. Analysis and quantification of demand response resources providing ancillary services is necessary to understand the resources economic value and impact on the power system. Methodologies used to study grid integration of variable generation can be adapted to the study of demand response. In the present work, we describe and illustrate a methodology to construct detailed temporal and spatial representations of the demand response resource and to examine how to incorporate those resources into power system models. In addition, the paper outlines ways to evaluate barriers to implementation. We demonstrate how the combination of these three analyses can be used to translate the technical potential for demand response providing ancillary services into a realizable potential.

  2. Complex Adaptive System of Systems (CASoS) Engineering Initiative

    E-Print Network [OSTI]

    ://www.sandia.gov/CasosEngineering/ SAND 2011-3354 P Complex Adaptive Systems of Systems (CASoS) E i i M i A i ti t P bl. · Recover or Change in response to events. · Control system behavior to avoid or steer the system towardsy y

  3. Essays on Agricultural Adaptation to Climate Change and Ethanol Market Integration in the U.S.

    E-Print Network [OSTI]

    Aisabokhae, Ruth 1980-

    2012-12-05T23:59:59.000Z

    to reduce the current and future extent of climate change. Biofuels production, for instance, expands agriculture’s role in climate change mitigation. This dissertation encompasses adaptation and mitigation strategies as a response to climate change...

  4. Making climate adaptation work : strategies for resource constrained South Asian mega-cities

    E-Print Network [OSTI]

    Dutta-Koehler, Madhu Chhanda

    2013-01-01T23:59:59.000Z

    This dissertation compares the responses of Dhaka, Bangladesh and Kolkata, India to the serious challenges posed by climate change, particularly in the water sector. Drawing on the theories of "adaptation as development" ...

  5. Adapting to Survive

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041cloth DocumentationProducts (VAP) VAP7-0973 1 IntroductionActinide ChemistryActivitiesAdapting to

  6. Adaptive Energy Grid

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041cloth DocumentationProducts (VAP) VAP7-0973 1 IntroductionActinide ChemistryActivitiesAdapting

  7. BRIDGING NAVIGATION, SEARCH AND ADAPTATION. Adaptive Hypermedia Models Evolution

    E-Print Network [OSTI]

    De Bra, Paul

    Corpus, Dexter Model, AHAM, GAF. Abstract: Adaptive Hypermedia Systems (AHS) have long been concentrating The most referenced (but certainly not only) Adaptive Hypermedia (AH) model dates back to 1999. Since AHAM/Hypermedia modelling from Dexter Model through AHAM to the proposed GAF model, out- line advantages of each framework

  8. I. INTRODUCTION Hierarchical Adaptive Kalman

    E-Print Network [OSTI]

    Ghosh, Joydeep

    I. INTRODUCTION Hierarchical Adaptive Kalman Filtering for Interplanetary Orbit Determination of Texas at Austin A modular and flexibleapproach to adaptive Kalman filtering has recently been introduced using the framework of a mixture-of-experts regulated by a gating network. Each expert is a Kalman

  9. Adaptation, Learning, and Optimization over

    E-Print Network [OSTI]

    California at Los Angeles, University of

    Adaptation, Learning, and Optimization over Networks Ali H. Sayed University of California at Los 2014 A. H. Sayed DOI: 10.1561/2200000051 Adaptation, Learning, and Optimization over Networks Ali H . . . . . . . . . . . . . . . . . . . . . . . . . 7 1.6 Notation and Symbols . . . . . . . . . . . . . . . . . . . . 8 2 Optimization by Single Agents

  10. Adaptive Optics in Star Formation

    E-Print Network [OSTI]

    Wolfgang Brandner

    2003-09-29T23:59:59.000Z

    Over the past ten years, the concept of adaptive optics has evolved from early experimental stages to a standard observing tool now available at almost all major optical and near-infrared telescope facilities. Adaptive optics will also be essential in exploiting the full potential of the large optical/infrared interferometers currently under construction. Both observations with high-angular resolution and at high contrast, and with a high point source sensitivity are facilitated by adaptive optics. Among the areas which benefit most from the use of adaptive optics are studies of the circumstellar environment (envelopes, disks, outflows), substellar companions and multiple systems, and dense young stellar populations. This contribution highlights some of the recent advances in star formation studies facilitated by adaptive optics, and gives a brief tutorial on optimized observing and data reduction strategies.

  11. Adaptive excitation control in power systems

    E-Print Network [OSTI]

    Chiu, Pei-Chen

    2006-08-16T23:59:59.000Z

    This thesis presents an adaptive excitation controller of power systems. The control law is derived by using model reference adaptive control (MRAC) or adaptive pole placement control (APPC) and an equilibrium tracking mechanism is implemented...

  12. adaptive response ar: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AR Representation AR Results Conclusion References Automated Reasoning in Modal Logics: A Framework with Applications Branden Fitelson Department of Philosophy Institute for...

  13. adaptive melanin response: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Sustainability. In February 2013, Athens of students to be future generators of sustainable value for business and society at large and to work Chatziantoniou, Damianos...

  14. adaptive metabolic response: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    appear to be the structural manifestation of this cellular metabolic memory. Here, a new framework for molecular information storage in the cell is presented, which is...

  15. adaptive gene responses: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Sustainability. In February 2013, Athens of students to be future generators of sustainable value for business and society at large and to work Chatziantoniou, Damianos...

  16. the Adaptive Response, Genetic Haplo-Insufficiency and Genomic Instability

    SciTech Connect (OSTI)

    Geard, Charles R.

    2014-12-12T23:59:59.000Z

    The linear no-threshold (LNT) hypothesis is the driving force in the establishment of radiation protection standards. However, the scientific basis for linearity has been brought into question, particularly due to the concerns about induced radiation resistance as it pertains to oxidative stress. Specifically, we investigated the observation that tumor hypoxia is associated with malignant progression, increased metastases, chemo- and radioresistance and poor prognosis. Experiments were conducted with non-malignant 3T3/NIH cells and normal human lung fibroblasts (NHLF) that were subjected to ?-irradiation under the levels of oxygen resembling those in growing tumors, and related our data to the concentrations of dissolved oxygen (DO), which is a better indicator of the amounts of residual oxygen inside the cells cultured in the hypoxic or anoxic atmosphere. We found that at DO levels about 0.5 mg/L cells subjected to both short-term (17 hours) and prolonged (48-72 hours) hypoxia continued to proliferate, and that apoptotic events were decreased at the early hours of hypoxic treatment. We showed that the short-term hypoxia up-regulated p53-binding protein 1 (53BP1) and resulted in facilitated 53BP1 nuclear foci formation and disappearance, thus indicating the higher efficiency of DNA double strand breaks repair processes. The latter was confirmed by the lower micronuclei incidence in irradiated hypoxic cells.

  17. adaptive response induced: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NANOLAMINATES . Open Access Theses and Dissertations Summary: ??To characterize the self-propagating, high-temperature exothermic alloying reactions of NiAl nanoscaled...

  18. adaptive responses induced: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NANOLAMINATES . Open Access Theses and Dissertations Summary: ??To characterize the self-propagating, high-temperature exothermic alloying reactions of NiAl nanoscaled...

  19. Adaptable architecture : a computational exploration into responsive design systems

    E-Print Network [OSTI]

    Zulas, Alejandro, 1976-

    2004-01-01T23:59:59.000Z

    Based on the fact that architecture is, among other things, the crystallization of a mediation among design intentions (function), meaning and contextual constraints (performance), we as designers are obligated to produce ...

  20. Automated Grid Disruption Response System: Robust Adaptive Topology Control (RATC)

    SciTech Connect (OSTI)

    None

    2012-03-01T23:59:59.000Z

    GENI Project: The RATC research team is using topology control as a mechanism to improve system operations and manage disruptions within the electric grid. The grid is subject to interruption from cascading faults caused by extreme operating conditions, malicious external attacks, and intermittent electricity generation from renewable energy sources. The RATC system is capable of detecting, classifying, and responding to grid disturbances by reconfiguring the grid in order to maintain economically efficient operations while guaranteeing reliability. The RATC system would help prevent future power outages, which account for roughly $80 billion in losses for businesses and consumers each year. Minimizing the time it takes for the grid to respond to expensive interruptions will also make it easier to integrate intermittent renewable energy sources into the grid.

  1. Cellular Response to Ordered Collagen Layers on Mica

    E-Print Network [OSTI]

    Leow, Wee Wen

    2012-07-16T23:59:59.000Z

    matrix (ECM), whereby cells are constantly sensing and modifying their surroundings in response to physical stress or during processes like wound repair, cancer cell invasion, and morphogenesis, to create an environment which supports adaptation. To date...

  2. A Dynamic Platform for Runtime Adaptation

    E-Print Network [OSTI]

    Pham, Hubert

    We present a middleware platform for assembling pervasive applications that demand fault-tolerance and adaptivity in distributed, dynamic environments. Unlike typical adaptive middleware approaches, in which sophisticated ...

  3. An Adaptive Voltage Control Algorithm with Multiple Distributed Energy

    SciTech Connect (OSTI)

    Li, Huijuan [University of Tennessee, Knoxville (UTK); Li, Fangxing [ORNL; Adhikari, Sarina [ORNL; Xu, Yan [ORNL; Rizy, D Tom [ORNL; Kueck, John D [ORNL

    2009-01-01T23:59:59.000Z

    Distributed energy resources (DE) with power electronics (PE) interfaces with the right control are capable of providing reactive power related ancillary services. Voltage regulation in particular has drawn much attention. In this paper the challenges to control multiple DEs to regulate the local voltage in distribution systems is addressed and a decentralized adaptive voltage control method is proposed. The simulation results in different system conditions show that this adaptive voltage control method is capable of satisfying the fast response speed requirement without causing oscillation or instability of the system. Since this method has high tolerance to the shortage of the system parameters and can be widely adaptive to the variable operation situations of the power systems, it is very suited for the utility application.

  4. Mutations in Global Regulators Lead to Metabolic Selection during Adaptation to Complex Environments

    SciTech Connect (OSTI)

    Saxer, Gerda; Krepps, Michael D.; Merkley, Eric D.; Ansong, Charles; Kaiser, Brooke LD; Valovska, Marie-Thrse; Ristic, Nikola; Yeh, Ping T.; Prakash, Vittal; Leiser, Owen P.; Nakhleh, Luay; Gibbons, Henry S.; Kreuzer, Helen W.; Shamoo, Yousif

    2014-12-11T23:59:59.000Z

    Adaptation to ecologically complex environments can provide insights into the evolutionary dynamics and functional constraints encountered by organisms during natural selection. Unlike adaptation to a single limiting resource, adaptation to a new environment with abundant and varied resources can be difficult to achieve by small incremental changes since many mutations are required to achieve even modest gains in fitness. Since changing complex environments are quite common in nature, we investigated how such an epistatic bottleneck can be avoided to allow rapid adaptation. We show that adaptive mutations arise repeatedly in independently evolved populations in the context of greatly increased genetic and phenotypic diversity. We go on to show that weak selection requiring substantial metabolic reprogramming can be readily achieved by mutations in the global response regulator arcA and the stress response regulator rpoS. We identified 46 unique single-nucleotide variants of arcA and 18 mutations in rpoS, nine of which resulted in stop codons or large deletions, suggesting that a subtle modulation of ArcA function and knockouts of rpoS are largely responsible for the metabolic shifts leading to adaptation. These mutations allow a higher order “metabolic selection” that eliminates epistatic bottlenecks, which could occur when many changes would be required. Proteomic and carbohydrate analysis of adapting E. coli populations revealed an up-regulation of enzymes associated with the TCA cycle and amino acid metabolism and an increase in the secretion of putrescine. The overall effect of adaptation across populations is to redirect and efficiently utilize uptake and catabolism of abundant amino acids. Concomitantly, there is a pronounced spread of more ecologically limited strains that results from specialization through metabolic erosion. Remarkably, the global regulators arcA and rpoS can provide a “one-step” mechanism of adaptation to a novel environment, which highlights the importance of global resource management as a powerful strategy to adaptation.

  5. Climate Change, Adaptation, and Development

    E-Print Network [OSTI]

    Cole, Daniel H.

    2008-01-01T23:59:59.000Z

    adaptive efficiency in some LDC economies. At this point,capacity-building" in LDC parties. 22 Addition- ally, twoof the over-dependence of many LDC economies on sectors that

  6. Adaptive multiconfigurational wave functions

    SciTech Connect (OSTI)

    Evangelista, Francesco A., E-mail: francesco.evangelista@emory.edu [Department of Chemistry and Cherry L. Emerson Center for Scientific Computation, Emory University, Atlanta, Georgia 30322 (United States)

    2014-03-28T23:59:59.000Z

    A method is suggested to build simple multiconfigurational wave functions specified uniquely by an energy cutoff ?. These are constructed from a model space containing determinants with energy relative to that of the most stable determinant no greater than ?. The resulting ?-CI wave function is adaptive, being able to represent both single-reference and multireference electronic states. We also consider a more compact wave function parameterization (?+SD-CI), which is based on a small ?-CI reference and adds a selection of all the singly and doubly excited determinants generated from it. We report two heuristic algorithms to build ?-CI wave functions. The first is based on an approximate prescreening of the full configuration interaction space, while the second performs a breadth-first search coupled with pruning. The ?-CI and ?+SD-CI approaches are used to compute the dissociation curve of N{sub 2} and the potential energy curves for the first three singlet states of C{sub 2}. Special attention is paid to the issue of energy discontinuities caused by changes in the size of the ?-CI wave function along the potential energy curve. This problem is shown to be solvable by smoothing the matrix elements of the Hamiltonian. Our last example, involving the Cu{sub 2}O{sub 2}{sup 2+} core, illustrates an alternative use of the ?-CI method: as a tool to both estimate the multireference character of a wave function and to create a compact model space to be used in subsequent high-level multireference coupled cluster computations.

  7. Exploring scaling up community-based adaptation: A case study with the PRODUCE Project in Rangpur, Bangladesh 

    E-Print Network [OSTI]

    Harsoyo, Dwi, L. R.

    2012-11-29T23:59:59.000Z

    is an approach to respond to these immediate impacts by adjusting the natural or human systems in response to actual impacts of climate change. Community-based adaptation (CBA) is a bottom-up and development-oriented view of adaptation that accommodates...

  8. Type 2 diabetes severely impairs structural and functional adaptation of rat resistance arteries to chronic changes in blood flow

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Type 2 diabetes severely impairs structural and functional adaptation of rat resistance arteries : Diabetes impairs flow-mediated remodeling Address for Correspondence: Dr. Daniel Henrion, Pharm.D., Ph damages in type 2 diabetes. The capacity of the microcirculation to adapt or remodel in response

  9. Matrix adaptation in discriminative vector quantization

    E-Print Network [OSTI]

    Zachmann, Gabriel

    . Gabriel Zachmann (Computer Graphics) #12;Matrix adaptation in discriminative vector quantization Petra

  10. Towards the identification of the loci of adaptive 2 evolution

    E-Print Network [OSTI]

    Pardo-Diaz, Carolina; Salazar, Camilo; Jiggins, Chris D.

    2015-02-12T23:59:59.000Z

    to identify gene regions as well as genes that are responsible for its varia- tion (Stinchcombe & Hoekstra 2007; Nadeau & Jiggins 2010; Slate et al. 2010; Stapley et al. 2010; Martin & Jiggins 2013; Savolainen, Lascoux&Merila 2013;Wray 2013;Dittmar et al. 2014... ; Mackay, Stone & Ayroles 2009; Nadeau & Jiggins 2010; Stapley et al. 2010; Slate 2013) (Table 1). In sticklebacks, for example, pel- vic structures and pigmentation play adaptive roles as defen- sive structures against predation and crypsis, respectively...

  11. Modeling Cortical Plasticity Based on Adapting Lateral Interaction

    E-Print Network [OSTI]

    A neural network model called LISSOM for the cooperative self-organization of afferent and lateral connections in cortical maps is applied to modeling cortical plasticity. After self-organization, the LISSOM maps are in a dynamic equilibrium with the input, and reorganize like the cortex in response to simulated cortical lesions and intracortical microstimulation. The model predicts that adapting lateral interactions are fundamental to cortical reorganization, and suggests techniques to hasten recovery following sensory cortical surgery.

  12. Regulation of phosphate starvation response in Arabidopsis

    E-Print Network [OSTI]

    Thomas, Beth Elene Armstrong

    2007-04-25T23:59:59.000Z

    Biochemical Responses of Plants to Phosphate Starvation???. 3 Metabolic Adaptations to Decrease Plant Pi Requirements???. 9 Pi Starvation Regulated Gene Expression in Plants??????. 11... x LIST OF FIGURES FIGURE Page 1.1 Some known components and their relationship in the Pi starvation...

  13. Adaptive Liquid Crystal Windows

    SciTech Connect (OSTI)

    Taheri, Bahman; Bodnar, Volodymyr

    2011-12-31T23:59:59.000Z

    Energy consumption by private and commercial sectors in the U.S. has steadily grown over the last decade. The uncertainty in future availability of imported oil, on which the energy consumption relies strongly, resulted in a dramatic increase in the cost of energy. About 20% of this consumption are used to heat and cool houses and commercial buildings. To reduce dependence on the foreign oil and cut down emission of greenhouse gases, it is necessary to eliminate losses and reduce total energy consumption by buildings. To achieve this goal it is necessary to redefine the role of the conventional windows. At a minimum, windows should stop being a source for energy loss. Ideally, windows should become a source of energy, providing net gain to reduce energy used to heat and cool homes. It is possible to have a net energy gain from a window if its light transmission can be dynamically altered, ideally electronically without the need of operator assistance, providing optimal control of the solar gain that varies with season and climate in the U.S. In addition, the window must not require power from the building for operation. Resolution of this problem is a societal challenge and of national interest and will have a broad global impact. For this purpose, the year-round, allclimate window solution to provide an electronically variable solar heat gain coefficient (SHGC) with a wide dynamic range is needed. AlphaMicron, Inc. (AMI) developed and manufactured 1ft × 1ft prototype panels for the world’s first auto-adjusting Adaptive Liquid Crystal Windows (ALCWs) that can operate from sunlight without the need for external power source and demonstrate an electronically adjustable SHGC. This novel windows are based on AlphaMicron’s patented e-Tint® technology, a guesthost liquid crystal system implemented on flexible, optically clear plastic films. This technology is suitable both for OEM and aftermarket (retro-fitting) lamination to new and existing windows. Low level of power consumption by ALCWs allows for on-board power electronics for automatic matching of transmission through windows to varying climate conditions without drawing the power from the power grid. ALCWs are capable of transmitting more sunlight in winters to assist in heating and less sunlight in summers to minimize overheating. As such, they can change the window from being a source of energy loss to a source of energy gain. In addition, the scalable AMI’s roll-to-roll process, proved by making 1ft × 1ftALCW prototype panels, allows for cost-effective production of large-scale window panels along with capability to change easily their color and shape. In addition to architectural glazing in houses and commercial buildings, ALCWs can be used in other applications where control of sunlight is needed, such as green houses, used by commercial produce growers and botanical gardens, cars, aircrafts, etc.

  14. Adaptive Optics for Large Telescopes

    SciTech Connect (OSTI)

    Olivier, S

    2008-06-27T23:59:59.000Z

    The use of adaptive optics was originally conceived by astronomers seeking to correct the blurring of images made with large telescopes due to the effects of atmospheric turbulence. The basic idea is to use a device, a wave front corrector, to adjust the phase of light passing through an optical system, based on some measurement of the spatial variation of the phase transverse to the light propagation direction, using a wave front sensor. Although the original concept was intended for application to astronomical imaging, the technique can be more generally applied. For instance, adaptive optics systems have been used for several decades to correct for aberrations in high-power laser systems. At Lawrence Livermore National Laboratory (LLNL), the world's largest laser system, the National Ignition Facility, uses adaptive optics to correct for aberrations in each of the 192 beams, all of which must be precisely focused on a millimeter scale target in order to perform nuclear physics experiments.

  15. Training Adaptive Decision-Making.

    SciTech Connect (OSTI)

    Abbott, Robert G.; Forsythe, James C.

    2014-10-01T23:59:59.000Z

    Adaptive Thinking has been defined here as the capacity to recognize when a course of action that may have previously been effective is no longer effective and there is need to adjust strategy. Research was undertaken with human test subjects to identify the factors that contribute to adaptive thinking. It was discovered that those most effective in settings that call for adaptive thinking tend to possess a superior capacity to quickly and effectively generate possible courses of action, as measured using the Category Generation test. Software developed for this research has been applied to develop capabilities enabling analysts to identify crucial factors that are predictive of outcomes in fore-on-force simulation exercises.

  16. Obesity cannot be controlled through personal responsibility alone

    E-Print Network [OSTI]

    Viglas, Anastasios

    Obesity cannot be controlled through personal responsibility alone By Ben Brooks McDonald's cookies - a corporate defence strategy adapted from the tobacco and alcohol industries. By implication, obesity responsibility for obesity and diabetes would likely require highly invasive disincentives like sugar or beverage

  17. Original article Response of Pinus pinaster Ait. provenances at early

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    . pinaster in response to water shortage. These physiological adaptations complement known morphologicalOriginal article Response of Pinus pinaster Ait. provenances at early age to water supply. I. Water evolution of tissue water relations was assessed in 1-year-old seedlings of four Pinus pinaster Ait. prove

  18. Genetic shift in photoperiodic response correlated with global warming

    E-Print Network [OSTI]

    Cochran-Stafira, D. Liane

    Genetic shift in photoperiodic response correlated with global warming William E. Bradshaw observed in insects, birds, amphibians, and plants associated with global warm- ing during the latter half- tent with an adaptive evolutionary response to recent global warming. The latter half of the 20th

  19. adaptive control algorithm: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    24 25 Next Page Last Page Topic Index 1 ON AN ADAPTIVE CONTROL ALGORITHM FOR ADAPTIVE OPTICS APPLICATIONS Mathematics Websites Summary: ON AN ADAPTIVE CONTROL ALGORITHM FOR...

  20. BC Agriculture Climate Change Adaptation

    E-Print Network [OSTI]

    Pedersen, Tom

    BC Agriculture Climate Change Adaptation Risk + Opportunity Assessment Provincial Report executive summary #12;published March 2012 by the British Columbia Agriculture & Food Climate Action Initiative www.BCAgClimateAction.ca project funding provided by Agriculture and Agri-food Canada BC Ministry of Agriculture BC Ministry

  1. BC Agriculture Climate Change Adaptation

    E-Print Network [OSTI]

    Pedersen, Tom

    BC Agriculture Climate Change Adaptation Risk + Opportunity Assessment Provincial Report #12;published March 2012 by the British Columbia Agriculture & Food Climate Action Initiative www.BCAgClimateAction.ca project funding provided by Agriculture and Agri-food Canada BC Ministry of Agriculture BC Ministry

  2. Adaptive Noisy Clustering Michael CHICHIGNOUD

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    with respect to the Lebesgue measure. Since we observe a corrupted sample, a direct approach as the popular k-means is not suitable in this case. In this paper, we propose a noisy k-means minimization, which is based on the k-means an adaptive upper bound for a new selection rule, called ERC (Empirical Risk Comparison). This selection rule

  3. Hierarchical Adaptive Dynamic Power Management

    E-Print Network [OSTI]

    Chen, Yuanzhu Peter

    Hierarchical Adaptive Dynamic Power Management Zhiyuan Ren, Member, IEEE, Bruce H. Krogh, Fellow, IEEE, and Radu Marculescu, Member, IEEE Abstract--Dynamic power management aims at extending battery management strategies can lead to poor performance or unnecessary power consumption when there are wide

  4. Adaptive wiener image restoration kernel

    DOE Patents [OSTI]

    Yuan, Ding (Henderson, NV)

    2007-06-05T23:59:59.000Z

    A method and device for restoration of electro-optical image data using an adaptive Wiener filter begins with constructing imaging system Optical Transfer Function, and the Fourier Transformations of the noise and the image. A spatial representation of the imaged object is restored by spatial convolution of the image using a Wiener restoration kernel.

  5. Adaptive protection algorithm and system

    DOE Patents [OSTI]

    Hedrick, Paul (Pittsburgh, PA) [Pittsburgh, PA; Toms, Helen L. (Irwin, PA) [Irwin, PA; Miller, Roger M. (Mars, PA) [Mars, PA

    2009-04-28T23:59:59.000Z

    An adaptive protection algorithm and system for protecting electrical distribution systems traces the flow of power through a distribution system, assigns a value (or rank) to each circuit breaker in the system and then determines the appropriate trip set points based on the assigned rank.

  6. Process Control Minitoring by Stress Response

    SciTech Connect (OSTI)

    Hazen, Terry C.; Stahl, David A.

    2006-04-17T23:59:59.000Z

    Environmental contamination with a variety of pollutants hasprompted the development of effective bioremediation strategies. But howcan these processes be best monitored and controlled? One avenue underinvestigation is the development of stress response systems as tools foreffective and general process control. Although the microbial stressresponse has been the subject of intensive laboratory investigation, theenvironmental reflection of the laboratory response to specific stresseshas been little explored. However, it is only within an environmentalcontext, in which microorganisms are constantly exposed to multiplechanging environmental stresses, that there will be full understanding ofmicrobial adaptive resiliency. Knowledge of the stress response in theenvironment will facilitate the control of bioremediation and otherprocesses mediated by complex microbial communities.

  7. Adapting Your Home for More Accessible Living

    E-Print Network [OSTI]

    Harris, Janie

    2007-04-27T23:59:59.000Z

    It is important for people to live comfortably and independently in their homes. Homes can be adapted to aid people with various disabilities. This publication explains how to make such adaptations for people with vision loss, hearing loss, problems...

  8. IIR algorithms for adaptive line enhancement

    SciTech Connect (OSTI)

    David, R.A.; Stearns, S.D.; Elliott, G.R.; Etter, D.M.

    1983-01-01T23:59:59.000Z

    We introduce a simple IIR structure for the adaptive line enhancer. Two algorithms based on gradient-search techniques are presented for adapting the structure. Results from experiments which utilized real data as well as computer simulations are provided.

  9. Final Report What Will Adaptation Cost?

    E-Print Network [OSTI]

    ..................................................................................................................26 Task 3: Estimate Costs of Implementing Adaptation Strategies ....................................................................34 Task 2: Calculate the Capital and Maintenance CostsFinal Report What Will Adaptation Cost? An Economic Framework for Coastal Community Infrastructure

  10. CLIMATE VULNERABILITY AND ADAPTATION STUDY FOR

    E-Print Network [OSTI]

    CLIMATE VULNERABILITY AND ADAPTATION STUDY FOR CALIFORNIA Legal Analysis of Barriers's California Climate Change Center JULY 2012 CEC5002012019 Prepared for: California Energy Commission to that framework that would facilitate adaptation to climate change. Since such changes may be difficult

  11. Sequential optimization through adaptive design of experiments

    E-Print Network [OSTI]

    Wang, Hungjen, 1971-

    2007-01-01T23:59:59.000Z

    This thesis considers the problem of achieving better system performance through adaptive experiments. For the case of discrete design space, I propose an adaptive One-Factor-at-A-Time (OFAT) experimental design, study its ...

  12. Article original Adaptation digestive du lapin

    E-Print Network [OSTI]

    Boyer, Edmond

    Article original Adaptation digestive du lapin à la teneur en constituants pariétaux du régime ne diffère pas d'un régime à l'autre, du fait d'une régulation de l'énergie digestible ingérée. L le régime B. lapin / digestion / fibre / adaptation / transit Summary — Digestive adaptation

  13. Formally Analyzing Adaptive Flight Control Ashish Tiwari

    E-Print Network [OSTI]

    Tiwari, Ashish

    tiwari@csl.sri.com Abstract. We formally verify a direct model-reference adaptive control (MRAC) method adaptive flight control. The main source of our model is [8] and [1]. The high-level architectureFormally Analyzing Adaptive Flight Control Ashish Tiwari SRI International Menlo Park, CA 94025

  14. Climate Change Adaptation for Local Government

    E-Print Network [OSTI]

    Pedersen, Tom

    Climate Change Adaptation for Local Government A Resource Guide June 2011 Jenny Fraser, Adaptation to Climate Change Team, Simon Fraser University #12;Page 1 of 26 Climate Change Adaptation for Local: RESOURCES THAT SUPPORT CLIMATE CHANGE ASSESSMENT 3. Past and Future Climate Change and Its Impacts 4

  15. Anisotropic Grid Adaptation for Multiple Aerodynamic Outputs

    E-Print Network [OSTI]

    Peraire, Jaime

    Anisotropic Grid Adaptation for Multiple Aerodynamic Outputs David A. Venditti and David L Anisotropic grid­adaptive strategies are presented for viscous flow simulations in which the accurate estimation and Hessian-based anisotropic grid adaptation. Airfoil test cases are presented to demonstrate

  16. Adaptive security systems -- Combining expert systems with adaptive technologies

    SciTech Connect (OSTI)

    Argo, P.; Loveland, R.; Anderson, K. [and others

    1997-09-01T23:59:59.000Z

    The Adaptive Multisensor Integrated Security System (AMISS) uses a variety of computational intelligence techniques to reason from raw sensor data through an array of processing layers to arrive at an assessment for alarm/alert conditions based on human behavior within a secure facility. In this paper, the authors give an overview of the system and briefly describe some of the major components of the system. This system is currently under development and testing in a realistic facility setting.

  17. adaptive immune regulators: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ecosystem Adaptive Management Environmental Sciences and Ecology Websites Summary: ;2 Baltic Ecosystem Adaptive Management, BEAM, r ett tvrvetenskapligt...

  18. adapter protein tsad: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ecosystem Adaptive Management Environmental Sciences and Ecology Websites Summary: ;2 Baltic Ecosystem Adaptive Management, BEAM, r ett tvrvetenskapligt...

  19. adaptive numerical treatment: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ecosystem Adaptive Management Environmental Sciences and Ecology Websites Summary: ;2 Baltic Ecosystem Adaptive Management, BEAM, r ett tvrvetenskapligt...

  20. adaptive antitumor immunity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ecosystem Adaptive Management Environmental Sciences and Ecology Websites Summary: ;2 Baltic Ecosystem Adaptive Management, BEAM, r ett tvrvetenskapligt...

  1. adaptation azole drug: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ecosystem Adaptive Management Environmental Sciences and Ecology Websites Summary: ;2 Baltic Ecosystem Adaptive Management, BEAM, r ett tvrvetenskapligt...

  2. Mechanics and Applications of Pressure Adaptive Honeycomb

    E-Print Network [OSTI]

    Vos, Roelof

    2009-07-31T23:59:59.000Z

    calculations. In addition, I would like to express my gratitude to the undergraduate students that have helped with the preparations of the experiments: Lauren Kerth, Will Pflug, Tom O?Brien, Thomas Statsny, and Ryan Barnhart. v TABLE OF CONTENTS... and Curvature Induced by Pressure adaptive Honeycomb 55 3.2.1 Pressure adaptive Wing Section 60 3.2.2 Pressure adaptive Gurney Flap 63 3.2.3 Pressure adaptive Solid State Flap 65 3.2.4 Pressure adaptive Engine Inlet 67 vi 3.3 Actuation Sources 71 4.1 Cellular...

  3. Adaptive Stabilization of Nonlinear Stochastic Systems

    SciTech Connect (OSTI)

    Florchinger, P. [URA CNRS No. 399, Departement de Mathematiques, UFR MIM, Universite de Metz, Ile du Saulcy, F 57045 Metz Cedex (France)

    1998-07-15T23:59:59.000Z

    The purpose of this paper is to study the problem of asymptotic stabilization in probability of nonlinear stochastic differential systems with unknown parameters. With this aim, we introduce the concept of an adaptive control Lyapunov function for stochastic systems and we use the stochastic version of Artstein's theorem to design an adaptive stabilizer. In this framework the problem of adaptive stabilization of a nonlinear stochastic system is reduced to the problem of asymptotic stabilization in probability of a modified system. The design of an adaptive control Lyapunov function is illustrated by the example of adaptively quadratically stabilizable in probability stochastic differential systems.

  4. Center for Adaptive Optics* Santa Cruz,CA

    E-Print Network [OSTI]

    Grether, Gregory

    Center for Adaptive Optics* Santa Cruz,CA The Center for Adaptive Optics (CfAO) will concentrate on astronomical and vision science applications of adaptive optics and will reach out to other adaptive optics communities to share technologies. It will develop new instruments optimized for adaptive optics. Adaptive

  5. Response Elements

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2007-07-11T23:59:59.000Z

    The Guide provides acceptable methods for meeting the requirement of DOE O 151.1C for response elements that respond or contribute to response as needed in an emergency. Cancels DOE G 151.1-1, Volume 3-1, DOE G 151.1-1, Volume 3-2, DOE G 151.1-1, Volume 3-3, DOE G 151.1-1, Volume 3-4, DOE G 151.1-1, Volume 4-1, DOE G 151.1-1, Volume 4-2, DOE G 151.1-1, Volume 4-3, DOE G 151.1-1, Volume 4-4, DOE G 151.1-1, Volume 4-5, and DOE G 151.1-1, Volume 4-6.

  6. Adapting to Climate Change and Variability in the Great Lakes-St. Lawrence Basin Great Lakes-St. Lawrence Basin Project

    E-Print Network [OSTI]

    ; this is the adaptation component. Communication of climate change information to various publicsAdapting to Climate Change and Variability in the Great Lakes-St. Lawrence Basin 52 Great Lakes in response to potential climate change and variability. When we were preparing for this talk on what we have

  7. Adaptive management: a paradigm for remediation of public facilities

    SciTech Connect (OSTI)

    Janecky, David R [Los Alamos National Laboratory; Whicker, Jeffrey J [Los Alamos National Laboratory; Doerr, Ted B [NON LANL

    2009-01-01T23:59:59.000Z

    Public facility restoration planning traditionally focused on response to natural disasters and hazardous materials accidental releases. These plans now need to integrate response to terrorist actions. Therefore, plans must address a wide range of potential vulnerabilities. Similar types of broad remediation planning are needed for restoration of waste and hazardous material handling areas and facilities. There are strong similarities in damage results and remediation activities between unintentional and terrorist actions; however, the uncertainties associated with terrorist actions result in a re-evaluation of approaches to planning. Restoration of public facilities following a release of a hazardous material is inherently far more complex than in confined industrial settings and has many unique technical, economic, social, and political challenges. Therefore, they arguably involve a superset of drivers, concerns and public agencies compared to other restoration efforts. This superset of conditions increases complexity of interactions, reduces our knowledge of the initial conditions, and even condenses the timeline for restoration response. Therefore, evaluations of alternative restoration management approaches developed for responding to terrorist actions provide useful knowledge for large, complex waste management projects. Whereas present planning documents have substantial linearity in their organization, the 'adaptive management' paradigm provides a constructive parallel operations paradigm for restoration of facilities that anticipates and plans for uncertainty, multiple/simUltaneous public agency actions, and stakeholder participation. Adaptive management grew out of the need to manage and restore natural resources in highly complex and changing environments with limited knowledge about causal relationships and responses to restoration actions. Similarities between natural resource management and restoration of a facility and surrounding area(s) after a disruptive event suggest numerous advantages over preset linearly-structured plans by incorporating the flexibility and overlap of processes inherent in effective facility restoration. We discuss three restoration case studies (e.g., the Hart Senate Office Building anthrax restoration, Rocky Flats actinide remediation, and hurricane destruction restoration), that implement aspects of adaptive management but not a formal approach. We propose that more formal adoption of adaptive management principles could be a basis for more flexible standards to improve site-specific remediation plans under conditions of high uncertainty.

  8. Submitted to Vehicle System Dynamics An Adaptive Lateral Preview Driver Model

    E-Print Network [OSTI]

    Peng, Huei

    of the vehicle. The proposed driver model is developed using the adaptive predictive control (APC) framework inspires our interest in understanding human steering actions and the development of a driver model on the response of the vehicle. These tests can be performed with a steering and speed control robot, and thus can

  9. Performance of Adaptive Query Processing in the Mariposa Distributed Database Management System

    E-Print Network [OSTI]

    California at Irvine, University of

    present performance results which show that in multi-user situations, when response time is used assigns a price to perform a service and may adjust its prices as it sees fit. In designing Mariposa such as the effect of supply and demand on prices. We investigate the benefits of adaptive distributed query

  10. Adaptation of Log Domain Second Order Filters Implemented by Floating Gate MOSFETs

    E-Print Network [OSTI]

    Maryland at College Park, University of

    Amplifier (AFGA) and its use in bandpass filter structures with very low frequency response capability based on the first order low-pass filter design. Section II develops robust learning rules for adapting the opportunity to reject noise and improve signal quality dynamically in a variety of complex and demanding

  11. Adaptive Jitter Control for UPnP M-Search Kevin Mills and Christopher Dabrowski

    E-Print Network [OSTI]

    Adaptive Jitter Control for UPnP M-Search Kevin Mills and Christopher Dabrowski Information service-discovery system, UPnP, permits clients to include a jitter bound in multicast (M-Search) queries. Qualifying devices use the jitter bound to randomize timing of their responses. Initially, clients lack

  12. Climate Change Adaptation New Perspectives for Natural Resource Management and Conservation1

    E-Print Network [OSTI]

    Mazzotti, Frank

    Climate Change Adaptation New Perspectives for Natural Resource Management and Conservation1 Institute of Food and Agricultural Sciences February 2012 A Changing Climate for Conservation Climate change species of plants and animals are already shifting their distributions in response to climate change

  13. Rights-based evaluation of government responses to a given 'natural' disaster : Katrina as case study

    E-Print Network [OSTI]

    Haeffner, Melissa (Melissa Ann)

    2010-01-01T23:59:59.000Z

    Disaster impacts human mobility and a rights-based approach to disaster response is needed to protect the human rights of those who seek migration as an adaptation strategy. This paper deals with returning to a place after ...

  14. Dscam gene expression in invertebrate immunity : alternative splicing in response to diverse pathogens 

    E-Print Network [OSTI]

    Smith, Paul Hugh

    2012-11-30T23:59:59.000Z

    Invertebrates show enhanced immunity and even specific primed immunity in response to repeat infections, analogous to vertebrate adaptive immunity. Little is known of the mechanism for this phenomenon, or which molecules ...

  15. Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis

    E-Print Network [OSTI]

    Santagata, Sandro

    Unlike normal tissues, cancers experience profound alterations in protein homeostasis. Powerful innate adaptive mechanisms, especially the transcriptional response regulated by Heat Shock Factor 1 (HSF1), are activated in ...

  16. Issues in adaptive mesh refinement

    SciTech Connect (OSTI)

    Dai, William Wenlong [Los Alamos National Laboratory

    2009-01-01T23:59:59.000Z

    In this paper, we present an approach for a patch-based adaptive mesh refinement (AMR) for multi-physics simulations. The approach consists of clustering, symmetry preserving, mesh continuity, flux correction, communications, and management of patches. Among the special features of this patch-based AMR are symmetry preserving, efficiency of refinement, special implementation offlux correction, and patch management in parallel computing environments. Here, higher efficiency of refinement means less unnecessarily refined cells for a given set of cells to be refined. To demonstrate the capability of the AMR framework, hydrodynamics simulations with many levels of refinement are shown in both two- and three-dimensions.

  17. Demand Response and Open Automated Demand Response

    E-Print Network [OSTI]

    LBNL-3047E Demand Response and Open Automated Demand Response Opportunities for Data Centers G described in this report was coordinated by the Demand Response Research Center and funded by the California. Demand Response and Open Automated Demand Response Opportunities for Data Centers. California Energy

  18. INPUT CONSTRAINED ADAPTIVE TRACKING WITH APPLICATIONS TO

    E-Print Network [OSTI]

    Knobloch,Jürgen

    as models in several industries including continuous polymerization reactors, distillation columns tracking ac- curacy, quantified by > 0 set by the designer, is ensured. The adaptive control strategy does

  19. Training for Climate Adaptation in Conservation

    Broader source: Energy.gov [DOE]

    The Wildlife Conservation Society and the Northern Institute of Applied Climate Science are hosting this two-day training for climate adaptation.

  20. Protein Structure Suggests Role as Molecular Adapter

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protein Structure Suggests Role as Molecular Adapter Print To split and copy DNA during replication, all cellular organisms use a multicomponent molecular machine known as the...

  1. Optimization Online - An Adaptive Unified Differential Evolution ...

    E-Print Network [OSTI]

    Ji Qiang

    2015-02-19T23:59:59.000Z

    Feb 19, 2015 ... Abstract: In this paper, we propose a new adaptive unified differential evolution algorithm for single-objective global optimization. Instead of the ...

  2. GLOBAL AND ADAPTIVE SCALING IN A SEPARABLE ...

    E-Print Network [OSTI]

    2007-10-19T23:59:59.000Z

    programs confirm that Adaptive Global Scaling subsumes former scaling ...... Then, the compact convex set B of symmetric matrices eigeinvalues of which.

  3. Mainstreaming Climate Change Adaptation into Development Planning...

    Open Energy Info (EERE)

    Practitioners Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Mainstreaming Climate Change Adaptation into Development Planning: A Guide for Practitioners Agency...

  4. Assessing Climate Change Impacts, Vulnerability and Adaptation...

    Open Energy Info (EERE)

    The Case of Pantabangan-Carranglan Watershed Jump to: navigation, search Name Assessing Climate Change Impacts, Vulnerability and Adaptation: The Case of Pantabangan-Carranglan...

  5. adaptive-influence-matrix adaptive optics: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    adaptive-influence-matrix adaptive optics First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Adaptive...

  6. Biologically Effective Dose-Response Relationship for Breast Cancer Treated by Conservative Surgery and Postoperative Radiotherapy

    SciTech Connect (OSTI)

    Plataniotis, George A. [Department of Oncology, Aberdeen Royal Infirmary, Aberdeen (United Kingdom)], E-mail: george.plataniotis@nhs.net; Dale, Roger G. [Imperial College Healthcare NHS Trust, London (United Kingdom)

    2009-10-01T23:59:59.000Z

    Purpose: To find a biologically effective dose (BED) response for adjuvant breast radiotherapy (RT) for initial-stage breast cancer. Methods and Materials: Results of randomized trials of RT vs. non-RT were reviewed and the tumor control probability (TCP) after RT was calculated for each of them. Using the linear-quadratic formula and Poisson statistics of cell-kill, the average initial number of clonogens per tumor before RT and the average tumor cell radiosensitivity (alpha-value) were calculated. An {alpha}/{beta} ratio of 4 Gy was assumed for these calculations. Results: A linear regression equation linking BED to TCP was derived: -ln[-ln(TCP)] = -ln(No) + {alpha}{sup *} BED = -4.08 + 0.07 * BED, suggesting a rather low radiosensitivity of breast cancer cells (alpha = 0.07 Gy{sup -1}), which probably reflects population heterogeneity. From the linear relationship a sigmoid BED-response curve was constructed. Conclusion: For BED values higher than about 90 Gy{sub 4} the radiation-induced TCP is essentially maximizing at 90-100%. The relationship presented here could be an approximate guide in the design and reporting of clinical trials of adjuvant breast RT.

  7. Downhole tool adapted for telemetry

    DOE Patents [OSTI]

    Hall, David R. (Provo, UT); Fox, Joe (Provo, UT)

    2010-12-14T23:59:59.000Z

    A cycleable downhole tool such as a Jar, a hydraulic hammer, and a shock absorber adapted for telemetry. This invention applies to other tools where the active components of the tool are displaced when the tool is rotationally or translationally cycled. The invention consists of inductive or contact transmission rings that are connected by an extensible conductor. The extensible conductor permits the transmission of the signal before, after, and during the cycling of the tool. The signal may be continuous or intermittent during cycling. The invention also applies to downhole tools that do not cycle, but in operation are under such stress that an extensible conductor is beneficial. The extensible conductor may also consist of an extensible portion and a fixed portion. The extensible conductor also features clamps that maintain the conductor under stresses greater than that seen by the tool, and seals that are capable of protecting against downhole pressure and contamination.

  8. An adaptive radiation model for the origin of new gene functions

    E-Print Network [OSTI]

    Francino, M. Pilar

    2005-01-01T23:59:59.000Z

    An adaptive radiation model for the origin of new genePreadaptation Adaptive radiation Competition among closefor a specific niche Adaptive radiation model Adaptive gene

  9. E-Print Network 3.0 - adaptive systems theory Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    systems theory Page: << < 1 2 3 4 5 > >> 1 From Adaptive Hypermedia to the Adaptive Web Systems Summary: 1 From Adaptive Hypermedia to the Adaptive Web Systems Peter...

  10. ORIGINAL ARTICLE Mitigation needs adaptation: Tropical forestry

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    ORIGINAL ARTICLE Mitigation needs adaptation: Tropical forestry and climate change Manuel R adapt to this change. This paper discusses how tropical forestry practices can contribute to maintaining Forestry Research, P.O. Box 6596 JKPWB, Jakarta 10065, Indonesia e-mail: m.guariguata@cgiar.org J. P

  11. OPTIMAL CONTROL WITH ADAPTIVE INTERNAL DYNAMICS MODELS

    E-Print Network [OSTI]

    Vijayakumar, Sethu

    . The optimal feedback control law for systems with non-linear dynamics and non-quadratic costs can be foundOPTIMAL CONTROL WITH ADAPTIVE INTERNAL DYNAMICS MODELS Djordje Mitrovic, Stefan Klanke, and Sethu, optimal control, adaptive control, robot simulation Abstract: Optimal feedback control has been proposed

  12. Adaptive Web Sites: Automatically Synthesizing Web Pages

    E-Print Network [OSTI]

    Etzioni, Oren

    Adaptive Web Sites: Automatically Synthesizing Web Pages Mike Perkowitz Oren Etzioni Department interfaces Abstract The creation of a complex web site is a thorny problem in user interface design. In IJCAI '97, we challenged the AI community to address this problem by creating adaptive web sites: sites

  13. General Adaptive Replacement Policies Yannis Smaragdakis

    E-Print Network [OSTI]

    Smaragdakis, Yannis

    General Adaptive Replacement Policies Yannis Smaragdakis College of Computing Georgia Institute of Technology yannis@cc.gatech.edu ABSTRACT We propose a general scheme for creating adaptive replace- ment any two existing replacement policies so that the resulting policy provably can never perform worse

  14. ADAPTIVE MULTIMEDIA TRANSMISSION OVER THE INTERNET

    E-Print Network [OSTI]

    Bouras, Christos

    Chapter 20 ADAPTIVE MULTIMEDIA TRANSMISSION OVER THE INTERNET CHRISTOS BOURAS and APOSTOLOS GKAMAS that are available to multimedia applications can be modified very quickly. Multimedia applications must have to multimedia applications, we can use techniques both at the network and application layers. Adaptive

  15. Adaptive Communication Agent for Group Communication activities

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    , limited energy resources), system execute adaptive mechanisms by monitoring the data flow. Also, the actor-wide collaborative environment, managing the adaptive communication is a challenging task. It implies the monitoring and executed without manual intervention. This research is applied to a Crisis Management System (CMS) within

  16. Enabling Informed Adaptation of Reformed Instructional Materials

    E-Print Network [OSTI]

    Elby, Andy

    Enabling Informed Adaptation of Reformed Instructional Materials Rachel E. Scherr and Andrew Elby 20742 USA Abstract. Instructors inevitably need to adapt even the best reform materials to suit instructors, and video clips of students working on the materials. Our materials thus facilitate their own

  17. Adaptive Filtering of Multilingual Document Streams

    E-Print Network [OSTI]

    Oard, Doug

    the volume of new documents that must be examined by the user to manageable levels. This paper presents three techniques for extending adaptive monolingual text ltering techniques to manage multilingual document streamsAdaptive Filtering of Multilingual Document Streams Douglas W. Oard College of Library

  18. DAMS: Distributed Adaptive Metaheuristic Selection Bilel Derbel

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    DAMS: Distributed Adaptive Metaheuristic Selection Bilel Derbel Université Lille 1 LIFL ­ CNRS Metaheuristic Selection (DAMS) frame- work. DAMS is dedicated to adaptive optimization in distributed environments. Given a set of metaheuristics, the goal of DAMS is to coordinate their local execution

  19. A fuzzy-tuned adaptive Kalman filter 

    E-Print Network [OSTI]

    Painter, John H.; Young Hwan Lho

    1993-12-01T23:59:59.000Z

    In this paper, fuzzy processing is applied to the adaptive Kalman filter. The filter gain coefficients are adapted over a 50 dB range of unknown signal/noise dynamics, using fuzzy membership functions. Specific simulation results are shown for a...

  20. Outreach and Adaptive Strategies for Climate Change

    E-Print Network [OSTI]

    Outreach and Adaptive Strategies for Climate Change: The Role of NOAA Sea Grant Extension years and generations about how to adapt to a changing climate. Effective preparation for possible effects of climate change includes engagement of resource managers, planners, public works officials

  1. A fuzzy-tuned adaptive Kalman filter

    E-Print Network [OSTI]

    Painter, John H.; Young Hwan Lho

    1993-12-01T23:59:59.000Z

    In this paper, fuzzy processing is applied to the adaptive Kalman filter. The filter gain coefficients are adapted over a 50 dB range of unknown signal/noise dynamics, using fuzzy membership functions. Specific simulation results are shown for a...

  2. Modeling progression in radiation-induced lung adenocarcinomas

    E-Print Network [OSTI]

    Fakir, Hatim; Hofmann, Werner; Sachs, Rainer K.

    2010-01-01T23:59:59.000Z

    carrying capacity. Indeed, Speer et al. (1984) showed thatdata for tumor growth (Speer et al. 1984). In our study,model. Math Biosci Speer JF, Petrosky VE, Retsky MW,

  3. accidental radiation-induced hematopoietic: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    solar and atmospheric neutrino oscillation, some of them can also induce neutrinoless double beta decay and mu- -- e+ conversion in nuclei large enough to be potentially...

  4. alleviates radiation-induced degeneration: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    solar and atmospheric neutrino oscillation, some of them can also induce neutrinoless double beta decay and mu- -- e+ conversion in nuclei large enough to be potentially...

  5. acute radiation-induced proctosigmoiditis: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    solar and atmospheric neutrino oscillation, some of them can also induce neutrinoless double beta decay and mu- -- e+ conversion in nuclei large enough to be potentially...

  6. abnormalities radiation-induced: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    solar and atmospheric neutrino oscillation, some of them can also induce neutrinoless double beta decay and mu- -- e+ conversion in nuclei large enough to be potentially...

  7. Radiation-induced chromosomal aberrations at different dose-rates

    E-Print Network [OSTI]

    McDaniel, Jackson Dean

    1965-01-01T23:59:59.000Z

    and sincere gratitude to Dr. G. M. Krise, for his advice and generosity, and to Dr. S. 0. Brown, for his vigilance throughout the course of this investigaticn. To Dr. H. R. Crookshank, I would like to acknowledge my indebtedness for serving as a sember... testicular cells eight hours postirradiation in animals given a total-body dose of 300 r at various dose rates . ; . . . . . . . . . . . , . . . . . . . . . . 17 II. Percentage of cells with aberrations per total dividing cells in the rat testes eight...

  8. Side slope design based on human tolerance to vehicle response

    E-Print Network [OSTI]

    Weaver, Graeme Douglas

    1970-01-01T23:59:59.000Z

    an investigation of simulated vehicle response to the traversal of roadside terrain features. A Texas Transportation Institute adaptation of the CALSVA model was utilized to quantify the relative lateral, longitudinal, and vertical acceleration levels generated... by traversal of roadside cross-sections commonly employed in highway design. STUDY -SOCEDURS The principal aim of this research was to investigate the vehicle dynamic response during traversal of various roadside terrain featuzes to provide a basis...

  9. Probing young massive clusters with laser guide star adaptive optics

    E-Print Network [OSTI]

    McCrady, Nate

    2009-01-01T23:59:59.000Z

    laser guide star adaptive optics Nate McCrady Received: 10laser guide star adaptive optics (LGS/AO) on the 10 m Keckof 4 Mpc. Our adaptive optics work is motivated by three

  10. An adaptive mesh refinement technique for dynamics of solids

    E-Print Network [OSTI]

    Trivedi, Abhishek

    2007-01-01T23:59:59.000Z

    adaptations; right: cut-off grid with a solution contour.adaptations; right: cut-off grid with a solution contour.

  11. adaptive signal detection: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8 INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING Int. J. Adapt. Control Signal Process. (in press) Engineering Websites Summary: predictive control 1....

  12. adaptive signal processing: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING Int. J. Adapt. Control Signal Process. (in press) Engineering Websites Summary: predictive control 1....

  13. adaptive information processing: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    52 INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING Int. J. Adapt. Control Signal Process. (in press) Engineering Websites Summary: predictive control 1....

  14. adapted damage control: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    40 INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING Int. J. Adapt. Control Signal Process. (in press) Engineering Websites Summary: predictive control 1....

  15. adaptive control: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    30 INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING Int. J. Adapt. Control Signal Process. (in press) Engineering Websites Summary: predictive control 1....

  16. adaptive predictive control: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    applied to analyze the transient Antsaklis, Panos 44 ADAPTIVE ROBUST TRACKING CONTROL OF PRESSURE Engineering Websites Summary: 1---- 1 ADAPTIVE ROBUST TRACKING CONTROL OF...

  17. active adaptive management: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    begun to embrace the concept adaptive management as an alternative to traditional natural resource planning and management models. Adaptive management may provide BLM managers ......

  18. adaptive management department: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    begun to embrace the concept adaptive management as an alternative to traditional natural resource planning and management models. Adaptive management may provide BLM managers ......

  19. National Adaptation Forum Webinar Series: Out of Town, Not Out...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Adaptation Forum Webinar Series: Out of Town, Not Out of Trouble: Small Agriculture and Indigenous Communities National Adaptation Forum Webinar Series: Out of Town, Not Out of...

  20. Farming in a Changing Climate: Agricultural Adaptation in Canada

    E-Print Network [OSTI]

    Jain, Varinder

    2010-01-01T23:59:59.000Z

    Agricultural Adaptation in Canada Ellen Wall, Barry Smit,Agricultural Adaptation in Canada. Vancouver, BC: Universitythe agri-food sector in Canada, the insights provided are so

  1. Enabling High Efficiency Low Temperature Combustion by Adaptive...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Low Temperature Combustion by Adaptive In-Situ Jet Cooling Enabling High Efficiency Low Temperature Combustion by Adaptive In-Situ Jet Cooling A new approach, called...

  2. adaptive interactive technologies: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Shock-induced combustion Fluid-structure interaction Implementation Parallel Adaptive Cartesian Upwind Mathematics Websites Summary: Finite volume methods Adaptive mesh refinement...

  3. adaptive optimal control: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    result. In this procedure it is essential Campi, Marco 3 Adaptive Control System Optimization for Vibration Control of Flexible Structures Engineering Websites Summary: Adaptive...

  4. adaptive particle swarm: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Last Page Topic Index 1 An Adaptive Learning Particle Swarm Optimizer for Function Optimization Computer Technologies and Information Sciences Websites Summary: An Adaptive...

  5. adaptive intrusion detection: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Last Page Topic Index 1 Adaptive Model Generation for Intrusion Detection Systems Computer Technologies and Information Sciences Websites Summary: Adaptive Model Generation for...

  6. Seismic Technology Adapted to Analyzing and Developing Geothermal...

    Broader source: Energy.gov (indexed) [DOE]

    Seismic Technology Adapted to Analyzing and Developing Geothermal Systems Below Surface-Exposed High-Velocity Rocks Seismic Technology Adapted to Analyzing and Developing...

  7. Implementing Adaptive Performance Management in Server Applications

    SciTech Connect (OSTI)

    Liu, Yan; Gorton, Ian

    2007-06-11T23:59:59.000Z

    Performance and scalability are critical quality attributes for server applications in Internet-facing business systems. These applications operate in dynamic environments with rapidly fluctuating user loads and resource levels, and unpredictable system faults. Adaptive (autonomic) systems research aims to augment such server applications with intelligent control logic that can detect and react to sudden environmental changes. However, developing this adaptive logic is complex in itself. In addition, executing the adaptive logic consumes processing resources, and hence may (paradoxically) adversely affect application performance. In this paper we describe an approach for developing high-performance adaptive server applications and the supporting technology. The Adaptive Server Framework (ASF) is built on standard middleware services, and can be used to augment legacy systems with adaptive behavior without needing to change the application business logic. Crucially, ASF provides built-in control loop components to optimize the overall application performance, which comprises both the business and adaptive logic. The control loop is based on performance models and allows systems designers to tune the performance levels simply by modifying high level declarative policies. We demonstrate the use of ASF in a case study.

  8. Adaptive control for optimizing microalgae production

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Adaptive control for optimizing microalgae production Francis Mairet Rafael Mu for light-limited microalgae culture. This controller regulates the light absorption factor, defined productivity under day-night cycles. Keywords: Nonlinear controller, Microalgae, Optimization, Biomass

  9. Exponential convergence with adaptive Monte Carlo

    SciTech Connect (OSTI)

    Booth, T.E.

    1997-11-01T23:59:59.000Z

    For over a decade, it has been known that exponential convergence on discrete transport problems was possible using adaptive Monte Carlo techniques. Now, exponential convergence has been empirically demonstrated on a spatially continuous problem.

  10. Adaptive Importance Sampling via Stochastic Convex Programming

    E-Print Network [OSTI]

    Adaptive Importance Sampling via Stochastic Convex Programming Ernest K. Ryu1 and Stephen P. Boyd1 Abstract We show that the variance of the Monte Carlo estimator that is importance sam- pled from

  11. Scalable Adaptive Multilevel Solvers for Multiphysics Problems

    SciTech Connect (OSTI)

    Xu, Jinchao

    2014-12-01T23:59:59.000Z

    In this project, we investigated adaptive, parallel, and multilevel methods for numerical modeling of various real-world applications, including Magnetohydrodynamics (MHD), complex fluids, Electromagnetism, Navier-Stokes equations, and reservoir simulation. First, we have designed improved mathematical models and numerical discretizaitons for viscoelastic fluids and MHD. Second, we have derived new a posteriori error estimators and extended the applicability of adaptivity to various problems. Third, we have developed multilevel solvers for solving scalar partial differential equations (PDEs) as well as coupled systems of PDEs, especially on unstructured grids. Moreover, we have integrated the study between adaptive method and multilevel methods, and made significant efforts and advances in adaptive multilevel methods of the multi-physics problems.

  12. Adaptive Reliability Analysis of Excavation Problems

    E-Print Network [OSTI]

    Park, Jun Kyung

    2012-10-19T23:59:59.000Z

    . This analysis couples the adaptive design capabilities of the observational method with updated reliability indices, to be used in risk-based design decisions. A probabilistic framework is developed to predict three-dimensional deformation profiles due...

  13. Robust adaptive control of switched systems

    E-Print Network [OSTI]

    El-Rifai, Khalid, 1979-

    2007-01-01T23:59:59.000Z

    In this thesis, robust adaptive controllers are developed for classes of switched nonlinear systems. Switched systems are those governed by differential equations, which undergo vector field switching due to sudden changes ...

  14. Adaptive optic demonstrators for extremely large telescopes 

    E-Print Network [OSTI]

    Campbell, Michael Aloysius

    2011-06-27T23:59:59.000Z

    The next generation of ground-based optical/infrared (IR) telescopes will have primary mirrors of up to 42 m. To take advantage of the large potential increase in angular resolution, adaptive optics will be essential to ...

  15. Adaptive sampling in autonomous marine sensor networks

    E-Print Network [OSTI]

    Eickstedt, Donald Patrick

    2006-01-01T23:59:59.000Z

    In this thesis, an innovative architecture for real-time adaptive and cooperative control of autonomous sensor platforms in a marine sensor network is described in the context of the autonomous oceanographic network scenario. ...

  16. Fast Adaptive Silhouette Area based Template Matching

    E-Print Network [OSTI]

    Zachmann, Gabriel

    Fast Adaptive Silhouette Area based Template Matching Daniel Mohr and Gabriel Zachmann If (Technical Informatics and Computer Systems) Prof. Dr. Gabriel Zachmann (Computer Graphics) Prof. Dr Template Matching Daniel Mohr and Gabriel Zachmann Clausthal University of Technology, Department

  17. A Logical Characterization of Adaptive Educational Hypermedia

    E-Print Network [OSTI]

    Henze, Nicola

    reference models for adaptive hypermedia, e.g. the AHAM Reference Model [4], or the Munich Reference Model [20]. Both, the AHAM and Munich Reference Model, extend the Dexter Hypertext Model [16], and pro- vide

  18. Convert! : the adaptive reuse of churches

    E-Print Network [OSTI]

    Kiley, Christopher John, 1972-

    2004-01-01T23:59:59.000Z

    This thesis examines the phenomenon of vacated churches and analyzes the major issues underlying their adaptive reuse in order to help promulgate an awareness of the range of successful strategies and solutions that are ...

  19. Challenges of Adapting to a Changing Climate

    E-Print Network [OSTI]

    Hurd, Brian H.

    2008-01-01T23:59:59.000Z

    of Global Climate Change on Agriculture: An Interpretiveon U.S. Agriculture, in THE IMPACT OF CLIMATE CHANGE ON THEclimate change and the potential roles for adaptation are more severe for ecosystems than they are for managed systems like agriculture.

  20. Anisotropic Grid Adaptation for Multiple Aerodynamic Outputs

    E-Print Network [OSTI]

    Venditti, David A.

    Anisotropic grid–adaptive strategies are presented for viscous flow simulations in which the accurate prediction of multiple aerodynamic outputs (such as the lift, drag, and moment coefficients) is required from a single ...

  1. Developmental Plasticity Links Local Adaptation and Evolutionary

    E-Print Network [OSTI]

    Badyaev, Alex

    Developmental Plasticity Links Local Adaptation and Evolutionary Diversification in Foraging, University of Arizona, Tucson, Arizona Developmental plasticity is thought to reconcile the constraining role morphology into adulthood, providing an opportunity to directly examine the links between plasticity of bone

  2. Asymptotic normality of urn models for clinical trials with delayed response

    E-Print Network [OSTI]

    Zhang, Li-Xin

    normality of Yn in the GFU model. Typically, clinical trials do not result in immediate outcomes ­ that isAsymptotic normality of urn models for clinical trials with delayed response F E I FA N G H U 1, Zhejiang, Hangzhou 310028, P. R. China. E-mail: lxzhang@mail.hz.zj.cn For response-adaptive clinical trials

  3. Adaptive gain improves reactor control

    SciTech Connect (OSTI)

    Whatley, M.J.; Pott, D.C.

    1984-05-01T23:59:59.000Z

    An interesting application of the modern control theory technique called adaptive control is presently in use on a process located at a plant in the Standard Oil Co. (Ind.) system. The results of this application are: first, the transformation of an uncontrollable process to a controllable one; and, second, a significant economic savings to the corporation. It also shows that a detailed analysis of the mechanical, chemical and control systems can provide both the basis for revising an existing control system and some of the reasons why that system is inadequate. The contrast between classical and modern control theories is seen in four major areas. In classical systems, the controller manipulates the error to calculate its output. The error is subjected to a limited number of analog computing functions such as multiplication by a constant and integration. Each controller has one specific strategy--to hold the measured variable at the setpoint. And each controller controls only one variable, independent of all others. In a modern system, the controller can manipulate many different variables in addition to the error to compute its output. Its computing power is unlimited in a practical sense. It can do all classical computations plus many others, including a table look-up. The controller can independently change its strategy as a function of time or the condition of the process. It can also control many variables at one time to accomplish a complex objective. The implementation of a modern control theory project requires a good understanding of the dynamic, as well as the steady-state character of the process. As you can see we are limited only by our understanding of the process, our imagination, and the economics of the situation.

  4. Adaptation to water scarcity in glacier-dependent towns of the Indian Himalayas : impacts, adaptive responses, barriers, and solutions

    E-Print Network [OSTI]

    Sudhalkar, Amruta Anand

    2010-01-01T23:59:59.000Z

    Among the existing and projected impacts of climate change, impacts on water resources are expected to exacerbate the current and future threat of global water scarcity. Glacier-dependent societies are especially vulnerable ...

  5. The Durham ELT adaptive optics simulation platform

    E-Print Network [OSTI]

    Alastair Basden; Timothy Butterley; Richard Myers; Richard Wilson

    2006-11-09T23:59:59.000Z

    Adaptive optics systems are essential on all large telescopes where image quality is important. These are complex systems with many design parameters requiring optimisation before good performance can be achieved. The simulation of adaptive optics systems is therefore necessary to categorise the expected performance. This paper describes an adaptive optics simulation platform, developed at Durham University, which can be used to simulate adaptive optics systems on the largest proposed future extremely large telescopes (ELTs) as well as current systems. This platform is modular, object oriented and has the benefit of hardware application acceleration which can be used to improve the simulation performance, essential for ensuring that the run time of a given simulation is acceptable. The simulation platform described here can be highly parallelised using parallelisation techniques suited for adaptive optics simulation, whilst still offering the user complete control while the simulation is running. Results from the simulation of a ground layer adaptive optics system are provided as an example to demonstrate the flexibility of this simulation platform.

  6. IEEE INFOCOM 2001 1 Pricing Network Resources for Adaptive

    E-Print Network [OSTI]

    Wang, Xin

    , and provides a natural and equitable incentive for applications to adapt their service contract according

  7. Model Reference Adaptive Control Framework for Real Time Traffic

    E-Print Network [OSTI]

    Minnesota, University of

    Adaptive Control #12;12 Prescriptive Dynamic Traffic Assignment A Prediction Model and the Reference ModelModel Reference Adaptive Control Framework for Real Time Traffic Management Under Emergency Movement Volume Adaptive Controller Model Reference Adaptive Control (MRAC) Assumptions Super Zone Concept

  8. DCS1800/WCDMA ADAPTIVE VOLTAGE-CONTROLLED OSCILLATOR

    E-Print Network [OSTI]

    Serdijn, Wouter A.

    DCS1800/WCDMA ADAPTIVE VOLTAGE-CONTROLLED OSCILLATOR Aleksandar Tasiü, Wouter A. Serdijn and John R, an adaptive 2G/3G voltage-controlled oscillator (VCO) is described in this paper. For the DCS1800 operation with this reasoning, an adaptive 2G/3G voltage- controlled oscillator, meant for a dual-standard adaptive front

  9. Gain scheduling adaptive control strategies for HVDC systems to accommodate large disturbances

    SciTech Connect (OSTI)

    Reeve, J.; Sultan, M. (Univ. of Waterloo, Ontario (Canada))

    1994-02-01T23:59:59.000Z

    Techniques have been developed to permit the response of the controls for dc transmission systems to adapt to large system changes. A gain scheduling approach tunes the control as an on-line function of the effective short-circuit ratio and contingency indicators. The method has been tested by digital simulation, based on EMTP, of a back-to-back dc system. It has been found to be robust and control performance has been enhanced.

  10. Adaptive Plasticity and Plasticity as an Adaptation: A Selective Review of Plasticity in Animal Morphology and Life History

    E-Print Network [OSTI]

    Gotthard, Karl

    Adaptive Plasticity and Plasticity as an Adaptation: A Selective Review of Plasticity in Animal wide-ranging. All key REVIEW references should be cited. A summary is required. Adaptive plasticity and plasticity as an adaptation: a selective review of plasticity in animal morphology and life history Karl

  11. EcoAdapt Working Paper Series N1 Adaptation to climate change for local development

    E-Print Network [OSTI]

    Boyer, Edmond

    1 EcoAdapt Working Paper Series N°1 Adaptation to climate change for local development Análisis in terms of employment, water situation and land use, at a quantitative and qualitative level, in three and summer pastures, due to the geographic and climatic conditions. hal-01059368,version1-30Aug2014 #12

  12. A Rate-Adaptive Multimedia Multicasting Mechanism. . . 23 A Rate-Adaptive Multimedia Multicasting Mechanism in

    E-Print Network [OSTI]

    A Rate-Adaptive Multimedia Multicasting Mechanism. . . 23 A Rate-Adaptive Multimedia Multicasting and Multimedia Department ENST Bretagne, 2, rue de la Chataigneraie - CS 17607 35576 Cesson Sevigne Cedex rapidly. One of the major driving factors of WLANs is multimedia services such as VOD or HDTV delivered

  13. Adaptive and Non-Adaptive Distribution Functions for DSA Melanie Smith

    E-Print Network [OSTI]

    Mailler, Roger

    Adaptive and Non-Adaptive Distribution Functions for DSA Melanie Smith University of Tulsa 800 S. Tucker Drive Tulsa, OK 74104 melanie@utulsa.edu Sandip Sen University of Tulsa 800 S. Tucker Drive Tulsa, OK 74104 sandip-sen@utulsa.edu Roger Mailler University of Tulsa 800 S. Tucker Drive Tulsa, OK 74104

  14. Adapting to WisconsinAdapting to Wisconsin''ss Changing WatersChanging Waters

    E-Print Network [OSTI]

    Sheridan, Jennifer

    spells and droughts in some places, to colder cold spells and more violent storms, more intense flooding://wicci.wisc.edu #12;WICCI Identifying impacts and adaptation strategies Evaluate potential effects on industry, agriculture, tourism, and other human activities. Develop and recommend adaptation strategies. Mission: Assess

  15. Molecular dissection of the roles of the SOD genes in mammalian response to low dose irradiation

    SciTech Connect (OSTI)

    Eric Y. Chuang

    2006-08-31T23:59:59.000Z

    It has been long recognized that a significant fraction of the radiation-induced genetic damage to cells are caused by secondary oxidative species. Internal cellular defense systems against oxidative stress play significant roles in countering genetic damage induced by ionizing radiation. The role of the detoxifying enzymes may be even more prominent in the case of low-dose, low-LET irradiation, as the majority of genetic damage may be caused by secondary oxidative species. In this study we have attempted to decipher the roles of the superoxide dismutase (SOD) genes, which are responsible for detoxifying the superoxide anions. We used adenovirus vectors to deliver RNA interference (RNAi or siRNA) technology to down-regulate the expression levels of the SOD genes. We have also over-expressed the SOD genes by use of recombinant adenovirus vectors. Cells infected with the vectors were then subjected to low dose ?-irradiation. Total RNA were extracted from the exposed cells and the expression of 9000 genes were profiled by use of cDNA microarrays. The result showed that low dose radiation had clear effects on gene expression in HCT116 cells. Both over-expression and down-regulation of the SOD1 gene can change the expression profiles of sub-groups of genes. Close to 200 of the 9000 genes examined showed over two-fold difference in expression under various conditions. Genes with changed expression pattern belong to many categories that include: early growth response, DNA-repair, ion transport, apoptosis, and cytokine response.

  16. Advanced Demand Responsive Lighting

    E-Print Network [OSTI]

    Advanced Demand Responsive Lighting Host: Francis Rubinstein Demand Response Research Center demand responsive lighting systems ­ Importance of dimming ­ New wireless controls technologies · Advanced Demand Responsive Lighting (commenced March 2007) #12;Objectives · Provide up-to-date information

  17. HAZARDOUS MATERIALS EMERGENCY RESPONSE

    E-Print Network [OSTI]

    ANNEX Q HAZARDOUS MATERIALS EMERGENCY RESPONSE #12;ANNEX Q - HAZARDOUS MATERIALS EMERGENCY RESPONSE 03/10/2014 v.2.0 Page Q-1 PROMULGATION STATEMENT Annex Q: Hazardous Materials Emergency Response, and contents within, is a guide to how the University conducts a response specific to a hazardous materials

  18. Load attenuating passively adaptive wind turbine blade

    DOE Patents [OSTI]

    Veers, Paul S. (Albuquerque, NM); Lobitz, Donald W. (Albuquerque, NM)

    2003-01-01T23:59:59.000Z

    A method and apparatus for improving wind turbine performance by alleviating loads and controlling the rotor. The invention employs the use of a passively adaptive blade that senses the wind velocity or rotational speed, and accordingly modifies its aerodynamic configuration. The invention exploits the load mitigation prospects of a blade that twists toward feather as it bends. The invention includes passively adaptive wind turbine rotors or blades with currently preferred power control features. The apparatus is a composite fiber horizontal axis wind-turbine blade, in which a substantial majority of fibers in the blade skin are inclined at angles of between 15 and 30 degrees to the axis of the blade, to produces passive adaptive aeroelastic tailoring (bend-twist coupling) to alleviate loading without unduly jeopardizing performance.

  19. Load attenuating passively adaptive wind turbine blade

    DOE Patents [OSTI]

    Veers, Paul S.; Lobitz, Donald W.

    2003-01-07T23:59:59.000Z

    A method and apparatus for improving wind turbine performance by alleviating loads and controlling the rotor. The invention employs the use of a passively adaptive blade that senses the wind velocity or rotational speed, and accordingly modifies its aerodynamic configuration. The invention exploits the load mitigation prospects of a blade that twists toward feather as it bends. The invention includes passively adaptive wind turbine rotors or blades with currently preferred power control features. The apparatus is a composite fiber horizontal axis wind-turbine blade, in which a substantial majority of fibers in the blade skin are inclined at angles of between 15 and 30 degrees to the axis of the blade, to produces passive adaptive aeroelastic tailoring (bend-twist coupling) to alleviate loading without unduly jeopardizing performance.

  20. Chemical Spill Response Procedure Initial Response

    E-Print Network [OSTI]

    Chemical Spill Response Procedure Initial Response 1. Advise lab occupants of the spill-4500. If not, continue with step 4. Clean-Up 4. Ensure the spill area has adequate ventilation to clear gases is absorbed. If necessary, add more neutralizing powder. 9. If cleaning up a solvent, proceed to step 13. 10

  1. Grid and basis adaptive polynomial chaos techniques for sensitivity and uncertainty analysis

    SciTech Connect (OSTI)

    Perkó, Zoltán, E-mail: Z.Perko@tudelft.nl; Gilli, Luca, E-mail: Gilli@nrg.eu; Lathouwers, Danny, E-mail: D.Lathouwers@tudelft.nl; Kloosterman, Jan Leen, E-mail: J.L.Kloosterman@tudelft.nl

    2014-03-01T23:59:59.000Z

    The demand for accurate and computationally affordable sensitivity and uncertainty techniques is constantly on the rise and has become especially pressing in the nuclear field with the shift to Best Estimate Plus Uncertainty methodologies in the licensing of nuclear installations. Besides traditional, already well developed methods – such as first order perturbation theory or Monte Carlo sampling – Polynomial Chaos Expansion (PCE) has been given a growing emphasis in recent years due to its simple application and good performance. This paper presents new developments of the research done at TU Delft on such Polynomial Chaos (PC) techniques. Our work is focused on the Non-Intrusive Spectral Projection (NISP) approach and adaptive methods for building the PCE of responses of interest. Recent efforts resulted in a new adaptive sparse grid algorithm designed for estimating the PC coefficients. The algorithm is based on Gerstner's procedure for calculating multi-dimensional integrals but proves to be computationally significantly cheaper, while at the same it retains a similar accuracy as the original method. More importantly the issue of basis adaptivity has been investigated and two techniques have been implemented for constructing the sparse PCE of quantities of interest. Not using the traditional full PC basis set leads to further reduction in computational time since the high order grids necessary for accurately estimating the near zero expansion coefficients of polynomial basis vectors not needed in the PCE can be excluded from the calculation. Moreover the sparse PC representation of the response is easier to handle when used for sensitivity analysis or uncertainty propagation due to the smaller number of basis vectors. The developed grid and basis adaptive methods have been implemented in Matlab as the Fully Adaptive Non-Intrusive Spectral Projection (FANISP) algorithm and were tested on four analytical problems. These show consistent good performance both in terms of the accuracy of the resulting PC representation of quantities and the computational costs associated with constructing the sparse PCE. Basis adaptivity also seems to make the employment of PC techniques possible for problems with a higher number of input parameters (15–20), alleviating a well known limitation of the traditional approach. The prospect of larger scale applicability and the simplicity of implementation makes such adaptive PC algorithms particularly appealing for the sensitivity and uncertainty analysis of complex systems and legacy codes.

  2. Spinning Reserve From Responsive Loads

    SciTech Connect (OSTI)

    Kirby, B.J.

    2003-04-08T23:59:59.000Z

    Responsive load is the most underutilized reliability resource available to the power system today. It is currently not used at all to provide spinning reserve. Historically there were good reasons for this, but recent technological advances in communications and controls have provided new capabilities and eliminated many of the old obstacles. North American Electric Reliability Council (NERC), Federal Energy Regulatory Commission (FERC), Northeast Power Coordinating Council (NPCC), New York State Reliability Council (NYSRC), and New York Independent System Operator (NYISO) rules are beginning to recognize these changes and are starting to encourage responsive load provision of reliability services. The Carrier ComfortChoice responsive thermostats provide an example of these technological advances. This is a technology aimed at reducing summer peak demand through central control of residential and small commercial air-conditioning loads. It is being utilized by Long Island Power Authority (LIPA), Consolidated Edison (ConEd), Southern California Edison (SCE), and San Diego Gas and Electric (SDG&E). The technology is capable of delivering even greater response in the faster spinning reserve time frame (while still providing peak reduction). Analysis of demand reduction testing results from LIPA during the summer of 2002 provides evidence to back up this claim. It also demonstrates that loads are different from generators and that the conventional wisdom, which advocates for starting with large loads as better ancillary service providers, is flawed. The tempting approach of incrementally adapting ancillary service requirements, which were established when generators were the only available resources, will not work. While it is easier for most generators to provide replacement power and non-spinning reserve (the slower response services) than it is to supply spinning reserve (the fastest service), the opposite is true for many loads. Also, there is more financial reward for supplying spinning reserve than for supplying the other reserve services as a result of the higher spinning reserve prices. The LIPAedge program (LIPA's demand reduction program using Carrier ComfortChoice thermostats) provides an opportunity to test the use of responsive load for spinning reserve. With potentially 75 MW of spinning reserve capability already installed, this test program can also make an important contribution to the capacity needs of Long Island during the summer of 2003. Testing could also be done at ConEd ({approx}30 MW), SCE ({approx}15 MW), and/or SDG&E ({approx}15 MW). This paper is divided into six chapters. Chapter 2 discusses the contingency reserve ancillary services, their functions in supporting power system reliability, and their technical requirements. It also discusses the policy and tariff requirements and attempts to distinguish between ones that are genuinely necessary and ones that are artifacts of the technologies that were historically used to provide the services. Chapter 3 discusses how responsive load could provide contingency reserves (especially spinning reserve) for the power system. Chapter 4 specifically discusses the Carrier ComfortChoice responsive thermostat technology, the LIPAedge experience with that technology, and how the technology could be used to supply spinning reserve. Chapter 5 discusses a number of unresolved issues and suggests areas for further research. Chapter 6 offers conclusions and recommendations.

  3. Adaptive Training for Large Vocabulary Continuous

    E-Print Network [OSTI]

    Hain, Thomas

    Adaptive Training for Large Vocabulary Continuous Speech Recognition Kai Yu Hughes Hall College for the degree of Doctor of Philosophy #12;ii Summary In recent years, there has been a trend towards training is to train hidden Markov models (HMMs) on the whole data set as if all data comes from a single acoustic

  4. Semantic Web Technologies for the Adaptive Web

    E-Print Network [OSTI]

    Nejdl, Wolfgang

    23 Semantic Web Technologies for the Adaptive Web Peter Dolog1 and Wolfgang Nejdl2 1 Department.de Abstract. Ontologies and reasoning are the key terms brought into focus by the semantic web community. Formal representation of ontologies in a common data model on the web can be taken as a foundation

  5. Provenance Meets Adaptive Hypermedia Evgeny Knutov

    E-Print Network [OSTI]

    De Bra, Paul

    Provenance Meets Adaptive Hypermedia Evgeny Knutov Department of Computer Science Eindhoven University of Technology P.O. Box 513, 5600 MB Eindhoven, the Netherlands e.knutov@tue.nl Paul De Bra Department of Computer Science Eindhoven University of Technology P.O. Box 513, 5600 MB Eindhoven

  6. Adaptive Scheduling Algorithms for Planet Searches

    E-Print Network [OSTI]

    Eric B. Ford

    2007-12-17T23:59:59.000Z

    High-precision radial velocity planet searches have surveyed over ~2000 nearby stars and detected over ~200 planets. While these same stars likely harbor many additional planets, they will become increasingly challenging to detect, as they tend to have relatively small masses and/or relatively long orbital periods. Therefore, observers are increasing the precision of their observations, continuing to monitor stars over decade timescales, and also preparing to survey thousands more stars. Given the considerable amounts of telescope time required for such observing programs, it is important use the available resources as efficiently as possible. Previous studies have found that a wide range of predetermined scheduling algorithms result in planet searches with similar sensitivities. We have developed adaptive scheduling algorithms which have a solid basis in Bayesian inference and information theory and also are computationally feasible for modern planet searches. We have performed Monte Carlo simulations of plausible planet searches to test the power of adaptive scheduling algorithms. Our simulations demonstrate that planet searches performed with adaptive scheduling algorithms can simultaneously detect more planets, detect less massive planets, and measure orbital parameters more accurately than comparable surveys using a non-adaptive scheduling algorithm. We expect that these techniques will be particularly valuable for the N2K radial velocity planet search for short-period planets as well as future astrometric planet searches with the Space Interferometry Mission which aim to detect terrestrial mass planets.

  7. A Middleware Framework for the Adaptive Home

    E-Print Network [OSTI]

    Dommel, Hans-Peter

    -friendly access to customized energy-aware home control, as well as the basic ambient intelligence to make a home adapt to user behavior and environmental constraints. Keywords. Network middleware for smart homes behavior. Newer developments in outfitting homes with powerful telematic intelligence [3, 4] catering

  8. Adaptive wavelet deconvolution for strongly mixing sequences

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Adaptive wavelet deconvolution for strongly mixing sequences Christophe Chesneau Abstract square error over Besov balls, we explore the performances of two wavelet estimators: a standard linear, Strongly mixing, Adap- tivity, Wavelets, Hard thresholding. AMS 2000 Subject Classifications: 62G07, 62G20

  9. IBM Software Data Sheet IBM adaptive threat

    E-Print Network [OSTI]

    IBM Software Data Sheet IBM adaptive threat protection Stay ahead of security threats with a state-of-the-art network protection engine Highlights Identify high-risk threats and zero-day attacks with protocol-based, behavioral anomaly detection Protect end users against the latest web-based threats, such as SQL injection

  10. Adaptive, full-spectrum solar energy system

    DOE Patents [OSTI]

    Muhs, Jeffrey D.; Earl, Dennis D.

    2003-08-05T23:59:59.000Z

    An adaptive full spectrum solar energy system having at least one hybrid solar concentrator, at least one hybrid luminaire, at least one hybrid photobioreactor, and a light distribution system operably connected to each hybrid solar concentrator, each hybrid luminaire, and each hybrid photobioreactor. A lighting control system operates each component.

  11. Adaptation in constant utility nonstationary environments

    E-Print Network [OSTI]

    Littman, Michael L.

    ­stationary environments are so pathological. Even if the environment, when viewed as a monolithic function, may of the results created by the organism over some given lifespan determines the organism's fitness. The nasty, the fitness produced by any single mapping will be at the chance level. The adaptive challenge is to produce

  12. CLIMATE CHANGE ADAPTATIONS FOR LOCAL WATER MANAGEMENT

    E-Print Network [OSTI]

    CLIMATE CHANGE ADAPTATIONS FOR LOCAL WATER MANAGEMENT IN THE SAN FRANCISCO BAY AREA A White Paper from the California Energy Commission's California Climate Change Center JULY 2012 CEC Climate change will affect both sea level and the temporal and spatial distribution of runoff

  13. An Infrastructure for Adaptive Dynamic Optimization

    E-Print Network [OSTI]

    Amarasinghe, Saman

    An Infrastructure for Adaptive Dynamic Optimization Derek Bruening, Timothy Garnett, and Saman,timothyg,saman}@lcs.mit.edu Abstract Dynamic optimization is emerging as a promising ap- proach to overcome many of the obstacles static optimizations, there are very few for developing dynamic optimizations. We present a framework

  14. Grid adaptation for multiscale plasma simulations

    E-Print Network [OSTI]

    Ito, Atsushi

    Grid adaptation for multiscale plasma simulations Gian Luca Delzanno Los Alamos National Laboratory In collaboration with L. Chacon and J.M. Finn #12;delzanno@lanl.gov Outline · Introduction and motivation · Grid tests · New directions · Conclusions #12;delzanno@lanl.gov Outline · Introduction and motivation · Grid

  15. Climate Change Basics: Science, Adaptation, & Mitigation

    E-Print Network [OSTI]

    Fox-Kemper, Baylor

    Science Global atmospheric concentrations of carbon dioxide, methane and nitrous oxide have increased from ice cores spanning many thousands of years. The global increases in carbon dioxide concentrationClimate Change Basics: Science, Adaptation, & Mitigation with a Family Forest Perspective Baylor

  16. Adaptation, Speciation, and Convergence: A Hierarchical Analysis of Adaptive Radiation in Caribbean Anolis Lizards

    E-Print Network [OSTI]

    Losos, Jonathan B.; Glor, Richard E.; Kolbe, Jason J.; Nicholson, Kirsten

    2006-05-01T23:59:59.000Z

    Caribbean Anolis lizards are a classic case of adaptive radiation, repeated four times across islands of the Greater Antilles. On each island, very similar patterns of evolutionary divergence have occurred, resulting in the evolution of the same set...

  17. The Complexity of Adaptation to Climate Change. Exploring adaptation in Rio Grande, Ecuador 

    E-Print Network [OSTI]

    Argudo, Cristina

    2014-11-27T23:59:59.000Z

    Climate change has become one of the most challenging problems in terms of development, having adverse effects in populations that are already vulnerable to other stressors. At present, the importance of adaptation to climate change has been widely...

  18. Funding for adaptation to climate change : the case of Surat

    E-Print Network [OSTI]

    Patel, Toral

    2014-01-01T23:59:59.000Z

    The need for cities to adapt to climate change is widely acknowledged, yet the question of adaptation finance remains uncertain. Unable to access global climate funds, cities must seek out alternative sources to support ...

  19. Learning from Monitoring & Evaluation a blueprint for an adaptive organisation

    E-Print Network [OSTI]

    Learning from Monitoring & Evaluation ­ a blueprint for an adaptive organisation Learning from Monitoring & Evaluation ­ a blueprint for an adaptive organisation Jake Morris and Anna Lawrence Social & Economic Research Group, Forest Research Aim and structure Learning is an essential characteristic

  20. Adaptive array antenna design for wireless communication systems 

    E-Print Network [OSTI]

    Noordin, Nurul Hazlina

    2013-11-28T23:59:59.000Z

    Adaptive array antennas use has been limited to non-commercial applications due to their high cost and hardware complexity. The implementation cost of adaptive array antennas can be kept to a minimum by using cost effective ...

  1. Evaluation and Adaptation of 5-Cycle Fuel Economy Testing and...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Adaptation of 5-Cycle Fuel Economy Testing and Calculations for HEVs and PHEVs Evaluation and Adaptation of 5-Cycle Fuel Economy Testing and Calculations for HEVs and PHEVs 2012...

  2. adaptive process control: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 ADAPTIVE OPTICS CONTROL FOR LASER MATERIAL PROCESSING Mathematics Websites Summary: ADAPTIVE OPTICS...

  3. Geometric Structure of the Adaptive Controller of the Human Arm

    E-Print Network [OSTI]

    Shadmehr, Reza

    1993-07-01T23:59:59.000Z

    The objects with which the hand interacts with may significantly change the dynamics of the arm. How does the brain adapt control of arm movements to this new dynamic? We show that adaptation is via composition of a ...

  4. Adaptive Treatment Strategies Getting SMART About Developing Individualized

    E-Print Network [OSTI]

    Murphy, Susan A.

    Other names are dynamic treatment regimes, treatment algorithms, stepped care models, expert systems: prevent relapse to alcohol abuse · Critical treatment decisions: which treatment to provide first?; which1 Adaptive Treatment Strategies Getting SMART About Developing Individualized Sequences of Adaptive

  5. adaptive fourier analyzer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    view or analyze the problem in n ways (n >2) Though we have defined these n- adaptive fuzzy models theorectically we are not in a position to get a n-adaptive fuzzy model for n...

  6. Accelerated Adaptive Markov Chain for Partition Function Computation

    E-Print Network [OSTI]

    Keinan, Alon

    Accelerated Adaptive Markov Chain for Partition Function Computation Stefano Ermon, Carla P. Gomes Ithaca NY 14853, U.S.A. Abstract We propose a novel Adaptive Markov Chain Monte Carlo algorithm

  7. Climate Change Adaptation: A Collective Action Perspective on Federalism Considerations

    E-Print Network [OSTI]

    Glicksman, Robert L.; Levy, Richard E.

    2010-01-01T23:59:59.000Z

    adaptation to minimize the adverse effects of climate change. Climate change adaptation is designed to increase the resilience of natural and human ecosystems to the threats posed by a changing environment. Although an extensive literature concerning...

  8. Performance of Adaptive DualDropping ILUT Preconditioners in Semiconductor

    E-Print Network [OSTI]

    Zhang, Jun

    Performance of Adaptive Dual­Dropping ILUT Preconditioners in Semiconductor Dopant Diffusion for iterative solution of sparse linear systems arising in semiconductor dopant diffusion modeling resolution, timestep in the adaptive ODE integrator and the problem physics. Key words: semiconductor TCAD

  9. Adaptive Robust Control of Robot Manipulators: Theory and Comparative Experiments

    E-Print Network [OSTI]

    Yao, Bin

    of the system such as gravitational load vary from a task to another, and, may not be precisely known in advance-based or direct adaptive control 21 , in which adaptation laws are used to adjust controller gains instead

  10. The Binding of Learning to Action in Motor Adaptation

    E-Print Network [OSTI]

    Gonzalez Castro, Luis Nicolas

    In motor tasks, errors between planned and actual movements generally result in adaptive changes which reduce the occurrence of similar errors in the future. It has commonly been assumed that the motor adaptation arising ...

  11. Optimal adaptive control of cascading power grid failures

    E-Print Network [OSTI]

    Daniel Bienstock

    2010-12-17T23:59:59.000Z

    Dec 17, 2010 ... Abstract: We describe experiments with parallel algorithms for computing adaptive controls for attenuating power grid cascading failures.

  12. Genomic islands predict functional adaptation in marine actinobacteria

    E-Print Network [OSTI]

    Penn, Kevin

    2010-01-01T23:59:59.000Z

    Ecological adaptations among bacterial populations have been linked to genomic islands, strain-specific regions of DNA that house

  13. BIA Request for Proposals for Climate Adaptation Grants for Tribes

    Broader source: Energy.gov [DOE]

    Download the Bureau of Indian Affairs Request for Proposals for Climate Adaptation Grants for Tribes, due November 29.

  14. Communication adapter for use with a drilling component

    DOE Patents [OSTI]

    Hall, David R. (Provo, UT); Pixton, David S. (Lehi, UT); Hall; Jr.; H. Tracy (Provo, UT); Bradford, Kline (Orem, UT); Rawle, Michael (Springville, UT)

    2007-04-03T23:59:59.000Z

    A communication adapter is disclosed that provides for removable attachment to a drilling component when the drilling component is not actively drilling and for communication with an integrated transmission system in the drilling component. The communication adapter comprises a data transmission coupler that facilitates communication between the drilling component and the adapter, a mechanical coupler that facilitates removable attachment of the adapter to the drilling component, and a data interface.

  15. Soil erosion from sugar beet in Central Europe in response to climate change induced seasonal precipitation variations

    E-Print Network [OSTI]

    Quinton, John

    of adaptive land-use management for climate change response strategies in the agricultural sector. © 2007; Conservation agriculture; Erosion modelling 1. Introduction Climate change of anthropogenic origin is widelySoil erosion from sugar beet in Central Europe in response to climate change induced seasonal

  16. Automated Web Page Synthesis in Adaptive Web Systems

    E-Print Network [OSTI]

    Ghorbani, Ali

    Automated Web Page Synthesis in Adaptive Web Systems Hossein Sadat and Ali Ghorbani Intelligent, Canada {t15h7,ghorbani}@unb.ca Abstract. An adaptive Web system adapts the Web pages to its users, based of the system. In this paper, we formalize dynamic generation of Web pages and refer to it as Web page synthesis

  17. MEDIA RESOURCES ADAPTATION FOR LIMITED DEVICES TAYEB LEMLOUMA1

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    MEDIA RESOURCES ADAPTATION FOR LIMITED DEVICES TAYEB LEMLOUMA1 ; NABIL LAYADA1 1 WAM Project, INRIA.Lemlouma@inrialpes.fr; Nabil.Layaida@inrialpes.fr In this paper, we define a framework for media resources manipulation in an adaptive content delivery system. We discuss the media resources manipulation in an adaptation

  18. An Adaptive Kalman Filter for Removing Baseline Wandering in ECG

    E-Print Network [OSTI]

    Povinelli, Richard J.

    An Adaptive Kalman Filter for Removing Baseline Wandering in ECG Signals MA Mneimneh, EE Yaz, MT to baseline removal. This paper proposes an adaptive Kalman filter for the real time re- moval of baseline is used with an adaptive Kalman filter to estimate the state variables, including the baseline wandering

  19. Adaptive Power Controlled Routing for Underwater Sensor Networks

    E-Print Network [OSTI]

    Zhou, Shengli

    Adaptive Power Controlled Routing for Underwater Sensor Networks Manal Al-Bzoor, Yibo Zhu, Jun Liu of an in- terest packet sent by sink nodes. We use adaptive power control to send at high power level the sink nodes using shortest end to end paths. By using adaptive power control over concentric layered

  20. Semantic Multimedia Document Adaptation with Functional Annotations Sebastien Laborie

    E-Print Network [OSTI]

    Joseph Fourier Grenoble-I, Université

    Semantic Multimedia Document Adaptation with Functional Annotations S´ebastien Laborie IRIT ­ Paul of presentation contexts for multimedia documents requires the adaptation of document specifica- tions. In an earlier work, we have proposed a seman- tic adaptation framework for multimedia documents. This framework

  1. Some Computational Problems Arising in Adaptive Optics Imaging Systems

    E-Print Network [OSTI]

    Plemmons, Robert J.

    Some Computational Problems Arising in Adaptive Optics Imaging Systems Robert J. Plemmons \\Lambda numerical linear algebra tech­ niques in adaptive optics imaging control computations. Real­time adaptive optics is a means for enhancing the resolution of ground based, optical telescopes beyond the limits

  2. Checking Sequence Construction Using Adaptive and Preset Distinguishing Sequences

    E-Print Network [OSTI]

    Jourdan, Guy-Vincent

    Checking Sequence Construction Using Adaptive and Preset Distinguishing Sequences Robert M. Hierons of a preset dis- tinguishing sequence for constructing checking sequences. It has been shown that an adaptive distinguishing sequence is sufficient for these methods. This result is significant because adaptive

  3. Grid adaptation for multiscale plasma simulations Gian Luca Delzanno

    E-Print Network [OSTI]

    Ito, Atsushi

    Grid adaptation for multiscale plasma simulations Gian Luca Delzanno Los Alamos National Laboratory tools need to be developed to bridge the gap between these disparate scales. Grid adaptation is one of such tools, useful to address multiple length scales, and we present a new powerful grid adaptation method

  4. Phenotypic plasticity facilitates recurrent rapid adaptation to introduced predators

    E-Print Network [OSTI]

    Pfrender, Michael

    Phenotypic plasticity facilitates recurrent rapid adaptation to introduced predators Alison G) A central role for phenotypic plasticity in adaptive evolution is often posited yet lacks empirical support of preexisting developmental pathways, producing rapid adaptive change. We examined the role of plasticity

  5. Adaptation Control in Adaptive Hypermedia Systems Hongjing Wu, Paul De Bra, Ad Aerts, GeertJan Houben

    E-Print Network [OSTI]

    De Bra, Paul

    model for the architecture of adaptive hypermedia applications: AHAM (for Adaptive Hypermedia Application Model) [DHW99], which is an extension of the Dexter hypermedia reference model [HS90, HS94]. AHAM

  6. Adaptation Control in Adaptive Hypermedia Systems Hongjing Wu, Paul De Bra, Ad Aerts, Geert-Jan Houben

    E-Print Network [OSTI]

    Houben, Geert-Jan

    model for the architecture of adaptive hypermedia applications: AHAM (for Adaptive Hypermedia Application Model) [DHW99], which is an extension of the Dexter hypermedia reference model [HS90, HS94]. AHAM

  7. SU-E-J-153: MRI Based, Daily Adaptive Radiotherapy for Rectal Cancer: Contour Adaptation

    SciTech Connect (OSTI)

    Kleijnen, J; Burbach, M; Verbraeken, T; Weggers, R; Zoetelief, A; Reerink, O; Lagendijk, J; Raaymakers, B; Asselen, B [University Medical Center Utrecht, Utrecht (Netherlands)

    2014-06-01T23:59:59.000Z

    Purpose: A major hurdle in adaptive radiotherapy is the adaptation of the planning MRI's delineations to the daily anatomy. We therefore investigate the accuracy and time needed for online clinical target volume (CTV) adaptation by radiation therapists (RTT), to be used in MRI-guided adaptive treatments on a MRI-Linac (MRL). Methods: Sixteen patients, diagnosed with early stage rectal cancer, underwent a T2-weighted MRI prior to each fraction of short-course radiotherapy, resulting in 4–5 scans per patient. On these scans, the CTV was delineated according to guidelines by an experienced radiation oncologist (RO) and considered to be the gold standard. For each patient, the first MRI was considered as the planning MRI and matched on bony anatomy to the 3–4 daily MRIs. The planning MRI's CTV delineation was rigidly propagated to the daily MRI scans as a proposal for adaptation. Three RTTs in training started the adaptation of the CTV conform guidelines, after a two hour training lecture and a two patient (n=7) training set. To assess the inter-therapist variation, all three RTTs altered delineations of 3 patients (n=12). One RTT altered the CTV delineations (n=53) of the remaining 11 patients. Time needed for adaptation of the CTV to guidelines was registered.As a measure of agreement, the conformity index (CI) was determined between the RTTs' delineations as a group. Dice similarity coefficients were determined between delineations of the RTT and the RO. Results: We found good agreement between RTTs' and RO's delineations (average Dice=0.91, SD=0.03). Furthermore, the inter-observer agreement between the RTTs was high (average CI=0.94, SD=0.02). Adaptation time reduced from 10:33 min (SD= 3:46) to 2:56 min (SD=1:06) between the first and last ten delineations, respectively. Conclusion: Daily CTV adaptation by RTTs, seems a feasible and safe way to introduce daily, online MRI-based plan adaptation for a MRL.

  8. RUMINAL ADAPTATION TO INCREASING LEVELS OF CONCENTRATES

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    .0 % citrus pulp, 1.0 % lard, 7.0 % sugarbeet pulp, 3.3 % oat husk meal, 2.0 % coconut expeller and 2-chromatography. The rate of lactate fermentation was measured by incubation of 10 ml rumen fluid (taken at 14.00 h) with 1. If adaptation occurs one should expect an increase of lactate and a higher rate of L- lactate fermentation

  9. Robust adaptive control of HVDC systems

    SciTech Connect (OSTI)

    Reeve, J.; Sultan, M. (Univ. of Waterloo, Ontario (Canada))

    1994-07-01T23:59:59.000Z

    The transient performance of an HVDC power system is highly dependent on the parameters of the current/voltage regulators of the converter controls. In order to better accommodate changes in system structure or dc operating conditions, this paper introduces a new adaptive control strategy. The advantages of automatic tuning for continuous fine tuning are combined with predetermined gain scheduling in order to achieve robustness for large disturbances. Examples are provided for a digitally simulated back-to-back dc system.

  10. Optimization Online - Adaptive Robust Optimization with Dynamic ...

    E-Print Network [OSTI]

    Alvaro Lorca

    2014-09-29T23:59:59.000Z

    Sep 29, 2014 ... Abstract: The exceptional benefits of wind power as an environmentally responsible renewable energy resource have led to an increasing ...

  11. Demand response enabling technology development

    E-Print Network [OSTI]

    Arens, Edward; Auslander, David; Huizenga, Charlie

    2008-01-01T23:59:59.000Z

    behavior in developing a demand response future. Phase_II_Demand Response Enabling Technology Development Phase IIYi Yuan The goal of the Demand Response Enabling Technology

  12. Demand Response Spinning Reserve Demonstration

    E-Print Network [OSTI]

    2007-01-01T23:59:59.000Z

    F) Enhanced ACP Date RAA ACP Demand Response – SpinningReserve Demonstration Demand Response – Spinning Reservesupply spinning reserve. Demand Response – Spinning Reserve

  13. Demand response enabling technology development

    E-Print Network [OSTI]

    2006-01-01T23:59:59.000Z

    Demand Response Enabling Technology Development Phase IEfficiency and Demand Response Programs for 2005/2006,Application to Demand Response Energy Pricing” SenSys 2003,

  14. Automated Demand Response and Commissioning

    E-Print Network [OSTI]

    Piette, Mary Ann; Watson, David S.; Motegi, Naoya; Bourassa, Norman

    2005-01-01T23:59:59.000Z

    and Demand Response in Commercial Buildings”, Lawrencesystems. Demand Response using HVAC in Commercial BuildingsDemand Response Test in Large Facilities13 National Conference on Building

  15. Adaptive powertrain control for plugin hybrid electric vehicles

    DOE Patents [OSTI]

    Kedar-Dongarkar, Gurunath; Weslati, Feisel

    2013-10-15T23:59:59.000Z

    A powertrain control system for a plugin hybrid electric vehicle. The system comprises an adaptive charge sustaining controller; at least one internal data source connected to the adaptive charge sustaining controller; and a memory connected to the adaptive charge sustaining controller for storing data generated by the at least one internal data source. The adaptive charge sustaining controller is operable to select an operating mode of the vehicle's powertrain along a given route based on programming generated from data stored in the memory associated with that route. Further described is a method of adaptively controlling operation of a plugin hybrid electric vehicle powertrain comprising identifying a route being traveled, activating stored adaptive charge sustaining mode programming for the identified route and controlling operation of the powertrain along the identified route by selecting from a plurality of operational modes based on the stored adaptive charge sustaining mode programming.

  16. CRA Comments & Responses

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    - High-Level Liquid Waste (51105) 11 Response to CRA Comments (92005) Enclosure 1 - Computer Code VerificationTesting (92005) Inventory and Performance Assessment Reports...

  17. GADRAS Detector Response Function.

    SciTech Connect (OSTI)

    Mitchell, Dean J.; Harding, Lee; Thoreson, Gregory G; Horne, Steven M.

    2014-11-01T23:59:59.000Z

    The Gamma Detector Response and Analysis Software (GADRAS) applies a Detector Response Function (DRF) to compute the output of gamma-ray and neutron detectors when they are exposed to radiation sources. The DRF is fundamental to the ability to perform forward calculations (i.e., computation of the response of a detector to a known source), as well as the ability to analyze spectra to deduce the types and quantities of radioactive material to which the detectors are exposed. This document describes how gamma-ray spectra are computed and the significance of response function parameters that define characteristics of particular detectors.

  18. Climate Change Response

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    the Interior Climate Change Response "From the Everglades to the Great Lakes to Alaska and everywhere in between, climate change is a leading threat to natural and cultural...

  19. Demand Response In California

    Broader source: Energy.gov [DOE]

    Presentation covers the demand response in California and is given at the FUPWG 2006 Fall meeting, held on November 1-2, 2006 in San Francisco, California.

  20. Method for removing tilt control in adaptive optics systems

    DOE Patents [OSTI]

    Salmon, Joseph Thaddeus (Livermore, CA)

    1998-01-01T23:59:59.000Z

    A new adaptive optics system and method of operation, whereby the method removes tilt control, and includes the steps of using a steering mirror to steer a wavefront in the desired direction, for aiming an impinging aberrated light beam in the direction of a deformable mirror. The deformable mirror has its surface deformed selectively by means of a plurality of actuators, and compensates, at least partially, for existing aberrations in the light beam. The light beam is split into an output beam and a sample beam, and the sample beam is sampled using a wavefront sensor. The sampled signals are converted into corresponding electrical signals for driving a controller, which, in turn, drives the deformable mirror in a feedback loop in response to the sampled signals, for compensating for aberrations in the wavefront. To this purpose, a displacement error (gradient) of the wavefront is measured, and adjusted by a modified gain matrix, which satisfies the following equation: G'=(I-X(X.sup.T X).sup.-1 X.sup.T)G(I-A)

  1. Method for removing tilt control in adaptive optics systems

    DOE Patents [OSTI]

    Salmon, J.T.

    1998-04-28T23:59:59.000Z

    A new adaptive optics system and method of operation are disclosed, whereby the method removes tilt control, and includes the steps of using a steering mirror to steer a wavefront in the desired direction, for aiming an impinging aberrated light beam in the direction of a deformable mirror. The deformable mirror has its surface deformed selectively by means of a plurality of actuators, and compensates, at least partially, for existing aberrations in the light beam. The light beam is split into an output beam and a sample beam, and the sample beam is sampled using a wavefront sensor. The sampled signals are converted into corresponding electrical signals for driving a controller, which, in turn, drives the deformable mirror in a feedback loop in response to the sampled signals, for compensating for aberrations in the wavefront. To this purpose, a displacement error (gradient) of the wavefront is measured, and adjusted by a modified gain matrix, which satisfies the following equation: G{prime} = (I{minus}X(X{sup T} X){sup {minus}1}X{sup T})G(I{minus}A). 3 figs.

  2. Eastern Frequency Response Study

    SciTech Connect (OSTI)

    Miller, N.W.; Shao, M.; Pajic, S.; D'Aquila, R.

    2013-05-01T23:59:59.000Z

    This study was specifically designed to investigate the frequency response of the Eastern Interconnection that results from large loss-of-generation events of the type targeted by the North American Electric Reliability Corp. Standard BAL-003 Frequency Response and Frequency Bias Setting (NERC 2012a), under possible future system conditions with high levels of wind generation.

  3. Electrochemical Characterization of Escherichia coli Adaptive Response Protein AidB

    E-Print Network [OSTI]

    Hamill, Michael J.

    When exposed to known DNA-damaging alkylating agents, Escherichia coli cells increase production of four DNA repair enzymes: Ada, AlkA, AlkB, and AidB. The role of three enzymes (Ada, AlkA, and AlkB) in repairing DNA lesions ...

  4. Institutional perspectives on road pricing : essays on implementation, response, and adaptation

    E-Print Network [OSTI]

    Mahendra, Anjali, 1977-

    2008-01-01T23:59:59.000Z

    Road pricing involves charging road users a fee for the external social costs of using private vehicles. These costs typically remain unaccounted for in routine road transport operations and benefit-cost analyses. They ...

  5. Plant responses associated with adaptation to low nitrogen stresses in selected Cynodon cultivars

    E-Print Network [OSTI]

    Sifers, Samuel I.

    1986-01-01T23:59:59.000Z

    samples under each fertility rate. The sod plugs were transplanted as solid plugs into plastic pots 20 cm deep x 21 cm top diameter. Washed mortar sand, leached with distilled water, was used as the planting medium. The pH at the time of planting was 7...), which are practica1ly identical. The small percentage of nitrogen remaining in the plants probably represents refractory ti ssue ni tr ogen and woul d be unavai 1 able to sustain any future growth. No diseases were evident at the final observation...

  6. Geographic variation in phenotypic plasticity in response to dissolved oxygen in an African cichlid fish

    E-Print Network [OSTI]

    Nuismer, Scott L.

    Geographic variation in phenotypic plasticity in response to dissolved oxygen in an African cichlid variation in a population over a number of generations to result in a population that is locally adapted and plastic variation in gill and brain size among swamp (low oxygen; hypoxic) and river (normal oxygen

  7. Seismic Response Analysis of Different Buildings using Time-Invariant and Time-Variant Damping Coefficients

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Seismic Response Analysis of Different Buildings using Time- Invariant and Time- Variant Damping@obs.ujf-grenoble.fr Abstract Seismic signals are characterized by strong excitations, short durations, non-linearity and non has been introduced to help in adapting to the seismic signals where the amplitude is damped

  8. Adaptive Implicit Non-Equilibrium Radiation Diffusion

    SciTech Connect (OSTI)

    Philip, Bobby [ORNL; Wang, Zhen [ORNL; Berrill, Mark A [ORNL; Rodriguez Rodriguez, Manuel [ORNL; Pernice, Michael [Idaho National Laboratory (INL)

    2013-01-01T23:59:59.000Z

    We describe methods for accurate and efficient long term time integra- tion of non-equilibrium radiation diffusion systems: implicit time integration for effi- cient long term time integration of stiff multiphysics systems, local control theory based step size control to minimize the required global number of time steps while control- ling accuracy, dynamic 3D adaptive mesh refinement (AMR) to minimize memory and computational costs, Jacobian Free Newton-Krylov methods on AMR grids for efficient nonlinear solution, and optimal multilevel preconditioner components that provide level independent solver convergence.

  9. Adaptive schemes for incomplete quantum process tomography

    SciTech Connect (OSTI)

    Teo, Yong Siah [Centre for Quantum Technologies, National University of Singapore, Singapore 117543 (Singapore); NUS Graduate School for Integrative Sciences and Engineering, Singapore 117597 (Singapore); Englert, Berthold-Georg [Centre for Quantum Technologies, National University of Singapore, Singapore 117543 (Singapore); Department of Physics, National University of Singapore, Singapore 117542 (Singapore); Rehacek, Jaroslav; Hradil, Zdenek [Department of Optics, Palacky University, 17. listopadu 12, CZ-77146 Olomouc (Czech Republic)

    2011-12-15T23:59:59.000Z

    We propose an iterative algorithm for incomplete quantum process tomography with the help of quantum state estimation. The algorithm, which is based on the combined principles of maximum likelihood and maximum entropy, yields a unique estimator for an unknown quantum process when one has less than a complete set of linearly independent measurement data to specify the quantum process uniquely. We apply this iterative algorithm adaptively in various situations and so optimize the amount of resources required to estimate a quantum process with incomplete data.

  10. Adaptive Materials Inc | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to:Ezfeedflag JumpID-fTriWildcat 1AMEE Jump to:Ohio: Energy955°, -89.7755338° ShowAdaptive

  11. WeADAPT | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnualProperty Edit withTianlin BaxinUmweltVillageGraph HomeWaranaWater PowerWaverly MunicipalWeADAPT

  12. African Adaptation Programme | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual Siteof Energy 2,AUDITCaliforniaWeifangwiki HomeASNAddGlobeJumpAdaptations Programme Name

  13. Adapter plate assembly for adjustable mounting of objects

    DOE Patents [OSTI]

    Blackburn, R.S.

    1986-05-02T23:59:59.000Z

    An adapter plate and two locking discs are together affixed to an optic table with machine screws or bolts threaded into a fixed array of internally threaded holes provided in the table surface. The adapter plate preferably has two, and preferably parallel, elongated locating slots each freely receiving a portion of one of the locking discs for secure affixation of the adapter plate to the optic table. A plurality of threaded apertures provided in the adapter plate are available to attach optical mounts or other devices onto the adapter plate in an orientation not limited by the disposition of the array of threaded holes in the table surface. An axially aligned but radially offset hole through each locking disc receives a screw that tightens onto the table, such that prior to tightening of the screw the locking disc may rotate and translate within each locating slot of the adapter plate for maximum flexibility of the orientation thereof.

  14. Adapter plate assembly for adjustable mounting of objects

    DOE Patents [OSTI]

    Blackburn, Robert S. (Albuquerque, NM)

    1987-01-01T23:59:59.000Z

    An adapter plate and two locking discs are together affixed to an optic table with machine screws or bolts threaded into a fixed array of internally threaded holes provided in the table surface. The adapter plate preferably has two, and preferably parallel, elongated locating slots each freely receiving a portion of one of the locking discs for secure affixation of the adapter plate to the optic table. A plurality of threaded apertures provided in the adapter plate are available to attach optical mounts or other devices onto the adapter plate in an orientation not limited by the disposition of the array of threaded holes in the table surface. An axially aligned but radially offset hole through each locking disc receives a screw that tightens onto the table, such that prior to tightening of the screw the locking disc may rotate and translate within each locating slot of the adapter plate for maximum flexibility of the orientation thereof.

  15. The Adaptive Optics Lucky Imager: combining adaptive optics and lucky imaging

    E-Print Network [OSTI]

    Crass, Jonathan

    2014-07-01T23:59:59.000Z

    , in particular the adaptive optics system and a new type of wavefront sensor, the non-linear curvature wavefront sensor (nlCWFS), being used within the instrument. The development of the nlCWFS has been the focus of my work, bringing the technique from a...

  16. Supporting User Adaptation in Adaptive Hypermedia Applications Hongjing Wu, GeertJan Houben, Paul De Bra

    E-Print Network [OSTI]

    De Bra, Paul

    applications, named AHAM (for Adaptive Hypermedia Application Model) [DHW99]. In AHAM knowledge is represented through hierarchies of large composite abstract concepts as well as small atomic ones. AHAM also divides. In this paper, we concentrate on the user modeling aspects of AHAM, but also describe how they relate

  17. Supporting User Adaptation in Adaptive Hypermedia Applications Hongjing Wu, Geert-Jan Houben, Paul De Bra

    E-Print Network [OSTI]

    Houben, Geert-Jan

    applications, named AHAM (for Adaptive Hypermedia Application Model) [DHW99]. In AHAM knowledge is represented through hierarchies of large composite abstract concepts as well as small atomic ones. AHAM also divides. In this paper, we concentrate on the user modeling aspects of AHAM, but also describe how they relate

  18. Error Correction, Sensory Prediction, and Adaptation

    E-Print Network [OSTI]

    in the response of our proprioceptive neurons. The transmission lines that connect a robot's motors and sensors to issue commands in microseconds. In contrast, our transmission lines (axons) move information slower than

  19. The analysis of convergence for four adaptive filtering algorithms

    E-Print Network [OSTI]

    Sohn, Won

    1990-01-01T23:59:59.000Z

    . The Relation Between AREs of Estimators and Detectors . 29 IV THE ANALYSIS OF THE LMS AI, GORITHM AND ITS FAMILY 31 V A. General Case B. Same Steady-state MSE SIMULATION OF ADAPTIVE FILTERING ALGORITHMS . 42 VI A. Simulation Model 1. Adaptive... Equalization 2. System Identification B. Learning Curves of Adaptive Filtering Algorithms 1. Same Steady-state MSE . 2. Same Speed of Convergence. . . . . . . . . . C. Simulation Results for the ARE 1. Same Steady-state MSE . . 2. Same Speed...

  20. Frequency Response Analysis Tool

    SciTech Connect (OSTI)

    Etingov, Pavel V.; Kosterev, Dmitry; Dai, T.

    2014-12-31T23:59:59.000Z

    Frequency response has received a lot of attention in recent years at the national level, which culminated in the development and approval of North American Electricity Reliability Corporation (NERC) BAL-003-1 Frequency Response and Frequency Bias Setting Reliability Standard. This report is prepared to describe the details of the work conducted by Pacific Northwest National Laboratory (PNNL) in collaboration with the Bonneville Power Administration and Western Electricity Coordinating Council (WECC) Joint Synchronized Information Subcommittee (JSIS) to develop a frequency response analysis tool (FRAT). The document provides the details on the methodology and main features of the FRAT. The tool manages the database of under-frequency events and calculates the frequency response baseline. Frequency response calculations are consistent with frequency response measure (FRM) in NERC BAL-003-1 for an interconnection and balancing authority. The FRAT can use both phasor measurement unit (PMU) data, where available, and supervisory control and data acquisition (SCADA) data. The tool is also capable of automatically generating NERC Frequency Response Survey (FRS) forms required by BAL-003-1 Standard.

  1. adaptive localization regions: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    22 23 24 25 Next Page Last Page Topic Index 1 Developing regional and local scenarios for climate change mitigation and adaptation Geosciences Websites Summary: Developing regional...

  2. adapted mucoid strains: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    proposed by Francfort and Marigo in 19 Cremers, Daniel 2 Adaptation CiteSeer Summary: Climate change is expected to bring potentially significant changes to Washington States...

  3. adaptive supply survival: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pike, Ivy L. 2003-12-01 8 Edinburgh Research Explorer Partial costs of global climate change adaptation for the supply Biology and Medicine Websites Summary: Edinburgh Research...

  4. affects adaptive allocation: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of water allocation institutions on societys adaptability to prospective climate change. Such institutions include basic systems of water law, specific statutes, systems of...

  5. adaptive slot allocation: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of water allocation institutions on societys adaptability to prospective climate change. Such institutions include basic systems of water law, specific statutes, systems of...

  6. Adaptive Control to Improve Low Temperature Diesel Engine Combustion...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Control to Improve Low Temperature Diesel Engine Combustion Adaptive Control to Improve Low Temperature Diesel Engine Combustion Presentation given at DEER 2006, August 20-24,...

  7. adaptive control strategies: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    using any finite number of channel evaluations. Aram W. Harrow; Avinatan Hassidim; Debbie W. Leung; John Watrous 2009-09-01 12 CONTRIBUTED Adaptive Stochastic Control Energy...

  8. Mean and covariance matrix adaptive estimation for a weakly ...

    E-Print Network [OSTI]

    2011-01-25T23:59:59.000Z

    AMS 2000 subject classification: Primary: 62G05, 62M10; Secondary: 90C15. Key words and phrases: Adaptive estimation, weakly stationary process, stochastic ...

  9. adaptive finite element: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    properties and performance of the adaptive finite element approach to the design of nano-photonic components. Central issues are the construction of vectorial finite elements...

  10. adaptive finite elements: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    properties and performance of the adaptive finite element approach to the design of nano-photonic components. Central issues are the construction of vectorial finite elements...

  11. adaptation biological: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    1, 3, 4. Here Averof, Michalis 39 Master's theses projects: Adaptations to a warming Baltic Sea We look for candidates interested in aquatic ecology to work on projects...

  12. adapter protein sly1: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to their own needs. This is achieved by enabling users... Heeren, Bastiaan 2010-01-01 157 Baltic Ecosystem Adaptive Management Environmental Sciences and Ecology Websites Summary:...

  13. adaptation taenkbara konsekvenser: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Smart Grid holds the promise of providing the autonomous intelligence of distributed generation and storage within the Smart Grid. KEYWORDS | Adaptive stochastic control (ASC...

  14. adaptive distributed control: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Smart Grid holds the promise of providing the autonomous intelligence of distributed generation and storage within the Smart Grid. KEYWORDS | Adaptive stochastic control (ASC...

  15. adapting balanced scorecard: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Brusilovsky School of Information and the same links to all - Stores - Museums - Courses - News sites Adaptive Web-based systems and sites Brusilovsky, Peter 237...

  16. How to Integrate Climate Change Adaptation into National-Level...

    Open Energy Info (EERE)

    Integrate Climate Change Adaptation into National-Level Policy and Planning in the Water Sector Jump to: navigation, search Tool Summary LAUNCH TOOL Name: How to Integrate Climate...

  17. adaptive composite grid: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    space and ti... Thornburg, Jonathan 2009-01-01 10 Adaptive Rate Stream Processing for Smart Grid Applications on Clouds Computer Technologies and Information Sciences Websites...

  18. adaptive grid generation: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    space and ti... Thornburg, Jonathan 2009-01-01 12 Adaptive Rate Stream Processing for Smart Grid Applications on Clouds Computer Technologies and Information Sciences Websites...

  19. Adaptive finite element method for eddy current problems

    E-Print Network [OSTI]

    Adaptive finite element method for eddy current problems. In this chapter we shall discuss Maxwell's equations at very low frequencies. We also refer to [bo98 ...

  20. astec code adaptability: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Marom 1997-07-14 2 Adaptive decoding for dense and sparse evaluationinterpolation codes Computer Technologies and Information Sciences Websites Summary: with errors Decoding...

  1. adaptive chemistry dac: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Tool Needs for Faster Mainstream Acceptance of 3D Lim, Sung Kyu 5 Ethical Conduct in Science and Engineering Adapted from Chemistry-Biology Interface Program Ethics Materials...

  2. adaptive aberration correction: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 Accommodation with higher-order monochromatic aberrations corrected with adaptive optics Biology and Medicine Websites Summary: . However, the eye suffers from higher-order...

  3. adaptive signal model: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Michael Richard 1990-11-13 2 UNCORRECTED 2 Stochastic adaptive control model for traffic signal systems Environmental Sciences and Ecology Websites Summary: process. The model...

  4. adaptive hifu noise: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Noise Engineering Websites Summary: An Adaptive Noise Removal Approach for Restoration of Digital Images Corrupted by Multimodal Noise process compromises the performance of the...

  5. acquired behaviour adaptations: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and their envi- ronment affect each other; and representation of full life cycles. Ecology has contributed to agent-based modelling Boone, Randall B. 22 Adaptive Modelling...

  6. adaptive social immunity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to climate risk in the coffee sector of Chiapas, Mexico Environmental Sciences and Ecology Websites Summary: Social identity, perception and motivation in adaptation to...

  7. adaptive model predictive: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mining CERN Preprints Summary: Nullifying the servo bandwidth errors improves the strehl ratio by a substantial quantity in adaptive optics systems. An effective method for...

  8. adaptive control scheme: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    systems concepts. Based Alpcan, Tansu 5 Adaptive predictive lighting controllers for daylight artificial light integrated schemes. Open Access Theses and Dissertations Summary:...

  9. adapted phi29 motor: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    an adjustment in the tension felt by the transduction channels. It has been suggested that steady- state tension is regulated a mathematical model for an adaptation motor...

  10. adaptation project pay: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    is adapting Linux for use in enterprise-scale networking Michigan, University of 445 Siemens Global Studio Project: Experiences Adopting an Integrated GSD Infrastructure...

  11. adaptive antenna system: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    widely used in civil engineering to evaluate building's structural re-sistance to seismic events... Munoz, Freddy 2009-01-01 164 User Models for Adaptive Hypermedia and...

  12. adaptive nonparametric instrumental: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    both selects Faraway, Julian 27 Spanish Version of the Sport Satisfaction Instrument (SSI) Adapted to Physical Education CiteSeer Summary: The objective of this research was to...

  13. adaptive management tool: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    management as an alternative to traditional natural resource planning and management models. Adaptive management may provide BLM managers ... Brandenburg, Peter (Peter J.)...

  14. Central African Republic-National Adaptation Plan Global Support...

    Open Energy Info (EERE)

    manual, Publications, Workshop Website http:undp-alm.orgprojectsn Program Start 2013 Country Central African Republic Middle Africa References National Adaptation Plan...

  15. adaptive numerical methods: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Websites Summary: An adaptive numerical method for the Richards equation with root growth Olga Wilderotter and plant root growth is presented. It allows the calculation of the...

  16. activity trial adapt: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    addressed ways to reduce greenhouse gas emissions Acting on Climate Change effects on industry, agriculture, tourism, and other human activities. Develop and recommend adaptation...

  17. adaptive neural coding: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    examples and in an application to image compression. 1 Introduction The self Zachmann, Gabriel 42 Adaptive Control Using Combined Online and Background Learning Neural...

  18. adapted neural population: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    examples and in an application to image compression. 1 Introduction The self Zachmann, Gabriel 24 Adaptive Control Using Combined Online and Background Learning Neural...

  19. adaptive interferometer based: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    current hardware: the science camera, the wavefront sensor, and the adaptive secondary mirror. In preliminary testing, we have implemented an eye doctor'' grid search approach...

  20. adaptive human aware: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    they display afterwards. They also show significantly larger aftereffects than ... Roach, Louise 2007-01-01 15 An Adaptive Quality of Service Aware Middleware for Replicated...

  1. adaptations impaired oxidative: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    learning of phonetic consistency and generalized neural adaptation deficits in dyslexia MIT - DSpace Summary: Developmental dyslexia is a neurological condition that...

  2. Adaptive Injection Strategies (AIS) for Ultra-low Emissions Diesel...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Injection Strategies (AIS) for Ultra-low Emissions Diesel Engines Adaptive Injection Strategies (AIS) for Ultra-low Emissions Diesel Engines Presentation given at the 2007 Diesel...

  3. adaptive control design: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    deployment mechanism is also 497 DESIGNER INTEGRATION IN TRAINING CYCLES : IEEE LTSA MODEL ADAPTATION Computer Technologies and Information Sciences Websites Summary: . The...

  4. adapting cardiovascular training: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (more) Brown, Allan 1991-01-01 217 DESIGNER INTEGRATION IN TRAINING CYCLES : IEEE LTSA MODEL ADAPTATION Computer Technologies and Information Sciences Websites Summary: . The...

  5. adaptive design clinical: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    deployment mechanism is also 146 DESIGNER INTEGRATION IN TRAINING CYCLES : IEEE LTSA MODEL ADAPTATION Computer Technologies and Information Sciences Websites Summary: . The...

  6. Applying Climate Information for Adaptation Decision-Making:...

    Open Energy Info (EERE)

    Applying Climate Information for Adaptation Decision-Making: A Guidance and Resource Document Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Applying Climate...

  7. Financing Climate Adaptation and Mitigation in Rural Areas of...

    Open Energy Info (EERE)

    Countries Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Financing Climate Adaptation and Mitigation in Rural Areas of Developing Countries AgencyCompany...

  8. Quantitative Adaptation Analytics for Assessing Dynamic Systems of Systems.

    SciTech Connect (OSTI)

    Gauthier, John H.; Miner, Nadine E.; Wilson, Michael L.; Le, Hai D.; Kao, Gio K; Melander, Darryl J.; Longsine, Dennis Earl [Sandia National Laboratories, Unknown, Unknown; Vander Meer, Robert Charles,

    2015-01-01T23:59:59.000Z

    Our society is increasingly reliant on systems and interoperating collections of systems, known as systems of systems (SoS). These SoS are often subject to changing missions (e.g., nation- building, arms-control treaties), threats (e.g., asymmetric warfare, terrorism), natural environments (e.g., climate, weather, natural disasters) and budgets. How well can SoS adapt to these types of dynamic conditions? This report details the results of a three year Laboratory Directed Research and Development (LDRD) project aimed at developing metrics and methodologies for quantifying the adaptability of systems and SoS. Work products include: derivation of a set of adaptability metrics, a method for combining the metrics into a system of systems adaptability index (SoSAI) used to compare adaptability of SoS designs, development of a prototype dynamic SoS (proto-dSoS) simulation environment which provides the ability to investigate the validity of the adaptability metric set, and two test cases that evaluate the usefulness of a subset of the adaptability metrics and SoSAI for distinguishing good from poor adaptability in a SoS. Intellectual property results include three patents pending: A Method For Quantifying Relative System Adaptability, Method for Evaluating System Performance, and A Method for Determining Systems Re-Tasking.

  9. adaptive numerical dissipative: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    linear function while the frictional dissipation rate is a cubic power of surface wind speed, the dissipation rate is generally smaller Wang, Yuqing 7 An Adaptive Numerical...

  10. adaptive phase tracking: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    de 107 IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS FOR VIDEO TECHNOLOGY, VOL. 9, NO. 7, OCTOBER 1999 1025 Adaptive Motion Tracking Block Matching Algorithms for Video Coding...

  11. ADAPTIVE AND ROBUST TECHNIQUES (ART) FOR THERMOACOUSTIC TOMOGRAPHY

    E-Print Network [OSTI]

    Xie, Yao

    ADAPTIVE AND ROBUST TECHNIQUES (ART) FOR THERMOACOUSTIC TOMOGRAPHY By YAO XIE A DISSERTATION.1 Thermoacoustic Tomography . . . . . . . . . . . . . . . . . . . . . 1 1.2 Image Reconstruction Algorithms for TAT

  12. adaptive harvest management: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Workload. Martin, W. Powley, R. Horman, and P. Bird, "Workload Adaptation in Autonomic DBMs", Proceedings of CASCON 2006, Toronto, Canada, October 16 - 19, 2006, pp 161 - 173"...

  13. adaptive antioxidant methionine: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Departments of *Ecology for review July 26, 2005) Adaptive radiation is defined as the evolution of ecological and phenotypic diversity within a rapidly multiplying lineage....

  14. Development based climate change adaptation and mitigation-conceptual...

    Open Energy Info (EERE)

    countries AgencyCompany Organization: Lawrence Berkeley National Laboratory (LBNL) Sector: Climate, Energy, Land, Water Topics: Adaptation, Co-benefits assessment, -...

  15. adaptive regression modeling: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Information Sciences Websites Summary: Kernel smoothing is a widely used non-parametric pattern recognition technique. By nature, it suffers, adaptive metric, cross-vali-...

  16. adaptive learning environments: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    In Saarbrucken we are developing the web-based, user-adaptive, interactive learning environment Active 69 Medium-based design: Extending a medium to create and exploratory...

  17. Characterizing Uncertainty for Regional Climate Change Mitigation and Adaptation Decisions

    SciTech Connect (OSTI)

    Unwin, Stephen D.; Moss, Richard H.; Rice, Jennie S.; Scott, Michael J.

    2011-09-30T23:59:59.000Z

    This white paper describes the results of new research to develop an uncertainty characterization process to help address the challenges of regional climate change mitigation and adaptation decisions.

  18. adaptive optics parameters: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    projects for large telescopes demand a proper knowledge of atmospheric turbulence to design efficient adaptive optics systems in order to reach large Strehl ratios. However, the...

  19. Adaptation to Climate Variability and Change: A Guidance Manual...

    Open Energy Info (EERE)

    to Climate Variability and Change: A Guidance Manual for Development Planning Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Adaptation to Climate Variability and...

  20. Economic Evaluation of Climate Change Adaptation Projects: Approaches...

    Open Energy Info (EERE)

    of Climate Change Adaptation Projects: Approaches for the Agricultural Sector and Beyond Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Economic Evaluation of Climate...

  1. adaptive feedback control: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    45 Adaptive Management of Irrigation with Feedback Control to Avoid Groundwater Pollution by Nitrate University of California eScholarship Repository Summary: cmhr) Soil...

  2. Adaptive Injection Strategies (AIS) for Ultra-low Emissions Diesel...

    Broader source: Energy.gov (indexed) [DOE]

    * Motivation and background * Adaptive Injection Strategy (AIS) * Simulation and optimization - Two-Stage Combustion (TSC -- HCCI + Diffusion combustion) optimization using AIS...

  3. adaptive genetic algorithm: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    a xed crossover Emmerich, Michael 2 Self-Adaptive Genetic Algorithm for Constrained Optimization. Open Access Theses and Dissertations Summary: ??This study proposes a...

  4. adaptive sampling strategy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ADAPTATION STRATEGIES FOR SAN LUIS OBISPO COUNTY: Preliminary Climate Change Climate Change Center JULY 2012 CEC5002012054 Prepared for: California Energy Commission...

  5. adapted seawater microbiota: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the anticancer immune effects Cai, Long 8 Adaptation CiteSeer Summary: Climate change is expected to bring potentially significant changes to Washington States natural,...

  6. Adaptive Stack with Subdivided Cells for Improved Stability,...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    with Subdivided Cells for Improved Stability, Reliability, and Durability under Automotive Load Cycle Adaptive Stack with Subdivided Cells for Improved Stability, Reliability,...

  7. Seismic Technology Adapted to Analyzing and Developing Geothermal...

    Broader source: Energy.gov (indexed) [DOE]

    Program 2010 Peer Review Seismic Technology Adapted to Analyzing and Developing Geothermal Systems Below Surface-Exposed High-Velocity Rocks Principal Investigator: Bob A. Hardage...

  8. Apollo: Adaptive power optimization and Control for the land Warrior

    E-Print Network [OSTI]

    Pedram, Massoud

    Apollo: Adaptive power optimization and Control for the land Warrior Massoud Pedram Dept. of EE management Architecture organization techniquesArchitecture organization techniques Apollo TestbedApollo

  9. Intelligent Software Agents: Sensor Integration and Response

    SciTech Connect (OSTI)

    Kulesz, James J [ORNL; Lee, Ronald W [ORNL

    2013-01-01T23:59:59.000Z

    Abstract In a post Macondo world the buzzwords are Integrity Management and Incident Response Management. The twin processes are not new but the opportunity to link the two is novel. Intelligent software agents can be used with sensor networks in distributed and centralized computing systems to enhance real-time monitoring of system integrity as well as manage the follow-on incident response to changing, and potentially hazardous, environmental conditions. The software components are embedded at the sensor network nodes in surveillance systems used for monitoring unusual events. When an event occurs, the software agents establish a new concept of operation at the sensing node, post the event status to a blackboard for software agents at other nodes to see , and then react quickly and efficiently to monitor the scale of the event. The technology addresses a current challenge in sensor networks that prevents a rapid and efficient response when a sensor measurement indicates that an event has occurred. By using intelligent software agents - which can be stationary or mobile, interact socially, and adapt to changing situations - the technology offers features that are particularly important when systems need to adapt to active circumstances. For example, when a release is detected, the local software agent collaborates with other agents at the node to exercise the appropriate operation, such as: targeted detection, increased detection frequency, decreased detection frequency for other non-alarming sensors, and determination of environmental conditions so that adjacent nodes can be informed that an event is occurring and when it will arrive. The software agents at the nodes can also post the data in a targeted manner, so that agents at other nodes and the command center can exercise appropriate operations to recalibrate the overall sensor network and associated intelligence systems. The paper describes the concepts and provides examples of real-world implementations including the Threat Detection and Analysis System (TDAS) at the International Port of Memphis and the Biological Warning and Incident Characterization System (BWIC) Environmental Monitoring (EM) Component. Technologies developed for these 24/7 operational systems have applications for improved real-time system integrity awareness as well as provide incident response (as needed) for production and field applications.

  10. The design of energy-responsive commercial buildings

    SciTech Connect (OSTI)

    Ternoey, S.; Bickle, L.; Robbins, C.; Busch, R.; Mc Cord, K.

    1985-01-01T23:59:59.000Z

    This book is a practical guide for building designers who want to reduce the nonrenewable energy needs of commercial and institutional buildings. The book presents, compares, and interprets the most current information on the principles, advantages, and disadvantages of many energy-related design alternatives. Topics considered include reviewing and interpreting our collective learning experience, the range of possible solutions, energy-responsive climate-rejecting buildings, energy-responsive climate-adapted buildings, the range of possible design approaches, a framework for design, a recommended design approach, applying the recommended design approach: examples, the financial value of energy-responsive design, building energy analysis during early design stages, and component energy analysis during early design stages.

  11. Accident Response Group

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1991-09-20T23:59:59.000Z

    To establish Department of Energy (DOE) policy for DOE response to accidents and significant incidents involving nuclear weapons or nuclear weapon components. Cancels DOE O 5530.1. Canceled by DOE O 153.1.

  12. Adaptive SSL: Design, Implementation and Overhead Analysis submission for Work-in-Progress/Application Paper track.

    E-Print Network [OSTI]

    Newcastle upon Tyne, University of

    Adaptive SSL: Design, Implementation and Overhead Analysis submission for Work an adaptation controller for SSL (Secure Socket Layer), called Adaptive SSL. 1 Introduction Applications adaptation of the Secure Socket Layer (SSL) protocol [3]. Adaptive SSL (ASSL) aims to provide appropriate se

  13. Adaptive model training system and method

    DOE Patents [OSTI]

    Bickford, Randall L; Palnitkar, Rahul M; Lee, Vo

    2014-04-15T23:59:59.000Z

    An adaptive model training system and method for filtering asset operating data values acquired from a monitored asset for selectively choosing asset operating data values that meet at least one predefined criterion of good data quality while rejecting asset operating data values that fail to meet at least the one predefined criterion of good data quality; and recalibrating a previously trained or calibrated model having a learned scope of normal operation of the asset by utilizing the asset operating data values that meet at least the one predefined criterion of good data quality for adjusting the learned scope of normal operation of the asset for defining a recalibrated model having the adjusted learned scope of normal operation of the asset.

  14. Adaptive model training system and method

    DOE Patents [OSTI]

    Bickford, Randall L; Palnitkar, Rahul M

    2014-11-18T23:59:59.000Z

    An adaptive model training system and method for filtering asset operating data values acquired from a monitored asset for selectively choosing asset operating data values that meet at least one predefined criterion of good data quality while rejecting asset operating data values that fail to meet at least the one predefined criterion of good data quality; and recalibrating a previously trained or calibrated model having a learned scope of normal operation of the asset by utilizing the asset operating data values that meet at least the one predefined criterion of good data quality for adjusting the learned scope of normal operation of the asset for defining a recalibrated model having the adjusted learned scope of normal operation of the asset.

  15. Adaptable radiation monitoring system and method

    DOE Patents [OSTI]

    Archer, Daniel E. (Livermore, CA); Beauchamp, Brock R. (San Ramon, CA); Mauger, G. Joseph (Livermore, CA); Nelson, Karl E. (Livermore, CA); Mercer, Michael B. (Manteca, CA); Pletcher, David C. (Sacramento, CA); Riot, Vincent J. (Berkeley, CA); Schek, James L. (Tracy, CA); Knapp, David A. (Livermore, CA)

    2006-06-20T23:59:59.000Z

    A portable radioactive-material detection system capable of detecting radioactive sources moving at high speeds. The system has at least one radiation detector capable of detecting gamma-radiation and coupled to an MCA capable of collecting spectral data in very small time bins of less than about 150 msec. A computer processor is connected to the MCA for determining from the spectral data if a triggering event has occurred. Spectral data is stored on a data storage device, and a power source supplies power to the detection system. Various configurations of the detection system may be adaptably arranged for various radiation detection scenarios. In a preferred embodiment, the computer processor operates as a server which receives spectral data from other networked detection systems, and communicates the collected data to a central data reporting system.

  16. Weitzenböck's Torsion, Fermi Coordinates and Adapted Frames

    E-Print Network [OSTI]

    Donato Bini; Bahram Mashhoon

    2015-04-19T23:59:59.000Z

    We study Weitzenb\\"ock's torsion and discuss its properties. Specifically, we calculate the measured components of Weitzenb\\"ock's torsion tensor for a frame field adapted to static observers in a Fermi normal coordinate system that we establish along the world line of an arbitrary accelerated observer in general relativity. A similar calculation is carried out in the standard Schwarzschild-like coordinates for static observers in the exterior Kerr spacetime; we then compare our results with the corresponding curvature components. Our work supports the contention that in the extended general relativistic framework involving both the Levi-Civita and Weitzenb\\"ock connections, curvature and torsion provide complementary representations of the gravitational field.

  17. Adaptively refined large eddy simulations of clusters

    E-Print Network [OSTI]

    Maier, A; Schmidt, W; Niemeyer, J C

    2009-01-01T23:59:59.000Z

    We present a numerical scheme for modelling unresolved turbulence in cosmological adaptive mesh refinement codes. As a first application, we study the evolution of turbulence in the intra-cluster medium and in the core of a galaxy cluster. Simulations with and without subgrid scale model are compared in detail. Since the flow in the ICM is subsonic, the global turbulent energy contribution at the unresolved length scales is smaller than 1% of the internal energy. We find that the production of turbulence is closely correlated with merger events occurring in the cluster environment, and its dissipation locally affects the cluster energy budget. Because of this additional source of dissipation, the core temperature is larger and the density is smaller in the presence of subgrid scale turbulence than in the standard adiabatic run, resulting in a higher entropy core value.

  18. Adapting MARSSIM for FUSRAP site closure.

    SciTech Connect (OSTI)

    Johnson, R.; Durham, L.; Rieman, C.; Hoover, R.

    2001-12-21T23:59:59.000Z

    The Multi-Agency Radiation Survey and Site Investigation Manual (MARSSIM) provides a coherent, technically defensible process for establishing that exposed surfaces satisfy site cleanup requirements. Unfortunately, many sites have complications that challenge a direct application of MARSSIM. Example complications include Record of Decision (ROD) requirements that are not MARSSIM-friendly, the potential for subsurface contamination, and incomplete characterization information. These types of complications are typically the rule, rather than the exception, for sites undergoing radiologically-driven remediation and closure. One such site is the Formerly Utilized Sites Remedial Action Program (FUSRAP) Linde site in Tonawanda, New York. Cleanup of the site is currently underway. The Linde site presented a number of challenges to designing and implementing a closure strategy consistent with MARSSIM. This paper discusses some of the closure issues confronted by the U.S. Army Corps of Engineers Buffalo District at the Linde site, and describes how MARSSIM protocols were adapted to address these issues.

  19. 9 Towards Adaptive Management of Native Vegetation in Regional Landscapes

    E-Print Network [OSTI]

    Burgman, Mark

    management remains widely cited as the most logical and elegant frame- work for continuous improvement9 Towards Adaptive Management of Native Vegetation in Regional Landscapes David H Duncan1 of the `adaptive management' paradigm to natural resource man- agement, using regional management of native

  20. Particle Systems for Adaptive, Isotropic Meshing of CAD Models

    E-Print Network [OSTI]

    Utah, University of

    Particle Systems for Adaptive, Isotropic Meshing of CAD Models Jonathan R. Bronson, Joshua A adaptive triangular surface and tetrahedral volume meshes from CAD models. Input shapes are treated. These particles reach a good distribution by minimizing an energy computed in 3D world space, with movements

  1. Equivocal Blind Signatures and Adaptive UC-Security Aggelos Kiayias

    E-Print Network [OSTI]

    Equivocal Blind Signatures and Adaptive UC-Security Aggelos Kiayias Hong-Sheng Zhou April 12, 2007 Abstract We study the design of practical blind signatures in the universal composability (UC) setting against adaptive adversaries. We introduce a new property for blind signature schemes

  2. Adaptive Blind Signal Processing--Neural Network Approaches

    E-Print Network [OSTI]

    Vialatte, François

    Adaptive Blind Signal Processing--Neural Network Approaches SHUN-ICHI AMARI, FELLOW, IEEE are presented for the problem of adaptive blind signal processing, especially instantaneous blind separation and multichannel blind deconvolution/equalization of independent source signals. We dis- cuss recent developments

  3. Are three-dimensional spider webs defensive adaptations?

    E-Print Network [OSTI]

    Blackledge, Todd

    LETTER Are three-dimensional spider webs defensive adaptations? Todd A. Blackledge1 *, Jonathan A-mail: tab42@cornell.edu Abstract Spider webs result from complex behaviours that have evolved under many selective pressures. Webs have been primarily considered to be foraging adaptations, neglecting

  4. adapted fish chionodraco: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    adapted fish chionodraco First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 NEWS AND COMMENTARY Adaptive...

  5. ADAPTIVE FINITE ELEMENT FREQUENCY DOMAIN METHOD FOR EDDY CURRENT PROBLEMS

    E-Print Network [OSTI]

    Zheng, Weiying

    ADAPTIVE FINITE ELEMENT FREQUENCY DOMAIN METHOD FOR EDDY CURRENT PROBLEMS WEIYING ZHENG-harmonic eddy current problems in the case of three-dimensional isotropic and linear materials. We adopt. Time-harmonic Maxwell's equations, eddy current, adaptive finite element method, multiply connected

  6. adaptive optics experiment: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    adaptive optics experiment First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Adaptive Optical Transport...

  7. adaptive optics monitoring: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    adaptive optics monitoring First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Adaptive Optical Transport...

  8. adaptive optics demonstrator: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    adaptive optics demonstrator First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Adaptive optic...

  9. adaptive optics correction: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    adaptive optics correction First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Adaptive optic correction...

  10. adaptive optics optical: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    adaptive optics optical First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Adaptive Optical Transport...

  11. adaptive optics scanning: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    adaptive optics scanning First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Adaptive Scanning Optical...

  12. adaptive optics planet: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    adaptive optics planet First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 An Adaptive Optics Survey for...

  13. adaptive optics fundus: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    adaptive optics fundus First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Adaptive Optical Transport...

  14. adaptive optics ophthalmologic: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    adaptive optics ophthalmologic First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Adaptive Optical...

  15. adaptive agent architecture: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    adaptive agent architecture First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 An Adaptive Plan-Based...

  16. PRISM Support Initiative Adaptation of OASIS4 and TOYOA4

    E-Print Network [OSTI]

    PRISM Support Initiative Adaptation of OASIS4 and TOYOA4 to the PRISM Standard directory structure structure of the OASIS4 coupler and its toy cou- pled model "TOYOA4", recently adapted to the PRISM Standard directory structure version 2.4. OASIS4 and TOYOA4 are currently developed using that directory structure

  17. Power Transmission Network Design by Greedy Randomized Adaptive Path Relinking

    E-Print Network [OSTI]

    Fisher, Kathleen

    different solutions could be reached exploring these different trajectories. The electric power system1 Power Transmission Network Design by Greedy Randomized Adaptive Path Relinking Haroldo Faria Jr Adaptive Path Relinking, applied to solve static power transmission network design problems. This new

  18. Uncertainty, Performance, and Model Dependency in Approximate Adaptive Nonlinear Control

    E-Print Network [OSTI]

    Szepesvari, Csaba

    Uncertainty, Performance, and Model Dependency in Approximate Adaptive Nonlinear Control M. French, and the performance of a class of approximate model based adaptive controllers is studied. An upper performance bound uncertainty model; control effort bounds require both L 2 and L 1 uncertainty models), and various structural

  19. A PRIORITY-BASED ADAPTIVE SCHEME FOR WIRELESS MULTIMEDIA DELIVERY

    E-Print Network [OSTI]

    A PRIORITY-BASED ADAPTIVE SCHEME FOR WIRELESS MULTIMEDIA DELIVERY Edward Casey and Gabriel, Dublin 9, Ireland Email: {caseye, munteang}@eeng.dcu.ie ABSTRACT In wireless multimedia streaming proposes a priority-based wireless adaptive multimedia delivery scheme that enables client prioritisation

  20. Multimedia Document Summarization based on a Semantic Adaptation Framework

    E-Print Network [OSTI]

    Boyer, Edmond

    Multimedia Document Summarization based on a Semantic Adaptation Framework Sébastien Laborie.Laborie,Jerome.Euzenat,Nabil.Layaida}@inrialpes.fr ABSTRACT The multiplication of presentation contexts (such as mo- bile phones, PDAs) for multimedia for multimedia document adaptation was proposed. This framework deals with the semantics of the document

  1. An Adaptive Mechanism For Pre-recorded Multimedia Streaming

    E-Print Network [OSTI]

    An Adaptive Mechanism For Pre-recorded Multimedia Streaming Based On Traffic Conditions Gabriel, Dublin-4, IRELAND ++353-1-716-2914 Liam.Murphy@ucd.ie ABSTRACT The multimedia streams transmissions, done-recorded multimedia streams, regardless the network condition. The adaptive mechanism is implemented by a feedback

  2. An Incremental Framework for Adapting the Hypermedia Structure of Multimedia

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    An Incremental Framework for Adapting the Hypermedia Structure of Multimedia Documents S.Laborie,Jerome.Euzenat}@inrialpes.fr Summary. The multiplication of presentation contexts (such as mobile phones, PDAs) for multimedia for multimedia document adaptation was proposed. This framework deals with the semantics of the document composi

  3. REVIEWS AND SYNTHESES Local adaptation in host use among marine

    E-Print Network [OSTI]

    Sotka, Erik

    , local adaptation, selection. Ecology Letters (2005) 8: 448­459 I N T R O DU C T I O N Population, abundance and ecological roles of organisms (Fox & Morrow 1981; Mopper & Strauss 1998), helps to maintain, there is a lingering perception that populations in the sea rarely locally adapt, and are more likely to evolve

  4. Adaptive beam profile control using a simulated annealing algorithm

    E-Print Network [OSTI]

    . Murnane, H. C. Kapteyn, S. Backus, G. Vdovin "Adaptive pulse compensation for transform-limited 15-fs high-energy transverse mode control and optimisation of an all-solid-state laser using an intracavity adaptive, the Netherlands, http://www.okotech.com. 10. Basler camera model A302f, http://www.basler-vc.com. 1. Introduction

  5. Speed adaptation in a powered transtibial prosthesis controlled with a

    E-Print Network [OSTI]

    Herr, Hugh

    Research Speed adaptation in a powered transtibial prosthesis controlled with a neuromuscular model a powered ankle­foot prosthesis and tested by an amputee walking at three speeds. The controller produced model; powered prosthesis; prosthesis control; speed adaptation 1. INTRODUCTION The human ankle

  6. Adaptive Optics in Astronomy Jay J. McCarthy

    E-Print Network [OSTI]

    La Rosa, Andres H.

    Adaptive Optics in Astronomy Jay J. McCarthy NW Computational Intelligence Laboratory Portland State University Abstract ­ The field of adaptive optics (AO) has developed as a means to correct for the phase disturbances of an optical signal by understanding the medium through which it passes. This paper

  7. Analysis of An Adaptive Sampler Based on Weber's Law

    E-Print Network [OSTI]

    Dabeer, Onkar

    1 Analysis of An Adaptive Sampler Based on Weber's Law Onkar Dabeer Subhasis Chaudhuri Onkar Dabeer;2 Abstract Weber's law suggests a logarithmic relationship between perceptual stimuli and human perception. The Weber sampler is an adaptive, non-uniform sampling mechanism that exploits Weber's law to sample

  8. A Pedagogical Interface for Authoring Adaptive e-Learning Courses

    E-Print Network [OSTI]

    Lau, W. H. Nynson

    to support adaptive e-learning course authoring for different types of students. They require teachers with its learning style type. When delivering a course, predefined rules and conditions are appliedA Pedagogical Interface for Authoring Adaptive e-Learning Courses Christopher Watson1 Frederick W

  9. Persona: a Framework to provide Adaptive Presentation for Web Documents

    E-Print Network [OSTI]

    Suzuki, Jun

    , yutaka, yama}@yy.cs.keio.ac.jp Abstract The current issue in the web document management is that every on the fly. Keywords Adaptive presentation, Web documents, Document management, Personalization 11 Persona: a Framework to provide Adaptive Presentation for Web Documents Junichi Suzuki, Gaku

  10. The Genetic Architecture of Adaptations to High Altitude in Ethiopia

    E-Print Network [OSTI]

    Dean, Matthew D.

    The Genetic Architecture of Adaptations to High Altitude in Ethiopia Gorka Alkorta-Aranburu1, Ethiopia, 4 Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America Abstract JK, et al. (2012) The Genetic Architecture of Adaptations to High Altitude in Ethiopia. PLoS Genet 8

  11. Adapting Optimization Techniques to Description Logics with Concrete Domains

    E-Print Network [OSTI]

    Haarslev, Volker

    Adapting Optimization Techniques to Description Logics with Concrete Domains Anni-Yasmin Turhan backtracking and model merging can be adapted to description logics with concrete domains. We propose al) a new requirement for concrete domains in order to enable dependency directed backtracking for all clash

  12. Adapting Optimization Techniques to Description Logics with Concrete Domains

    E-Print Network [OSTI]

    Haarslev, Volker

    Adapting Optimization Techniques to Description Logics with Concrete Domains Anni­Yasmin Turhan backtracking and model merging can be adapted to description logics with concrete domains. We propose al) a new requirement for concrete domains in order to enable dependency directed backtracking for all clash

  13. Lead User's theory adapted to services: Towards Service User's Toolkit

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Lead User's theory adapted to services: Towards Service User's Toolkit E. Stevens Prof under the perspective of networks and communities. Lead User's theory (LUT) focused mainly is to adapt lead user's theory and practice to the specific case of the intangible processes and services

  14. Adaptive Rate Stream Processing for Smart Grid Applications on Clouds

    E-Print Network [OSTI]

    Prasanna, Viktor K.

    Adaptive Rate Stream Processing for Smart Grid Applications on Clouds Yogesh Simmhan University within a smart (power) grid are providing utilities and power systems researchers with unprecedentedEngineering applications in the smart grid domain. One unique aspect of our work is the use of adaptive rate control

  15. Organizational Adaptation in Volatile Environments Kathleen M. Carley

    E-Print Network [OSTI]

    Sadeh, Norman M.

    Organizational Adaptation in Volatile Environments Kathleen M. Carley Dept. of Social and Decision. Citation: Kathleen M. Carley, 2000, "Organizational Adaptation in Volatile Environments" Ch. 11 in C. L. Hulin & D. R. Ilgen (Eds.) Computational Modeling in Organizational Behavior: The Third Scientific

  16. On Adaptive Mesh Refinement for Atmospheric Pollution Models

    E-Print Network [OSTI]

    Sandu, Adrian

    On Adaptive Mesh Refinement for Atmospheric Pollution Models Emil M. Constantinescu and Adrian res- olution system for modeling regional air pollution based on the chemical transport model STEM. Keywords: Air Pollution Modeling, Adaptive Mesh Refinement. 1 Introduction Inadequate grid resolution can

  17. CONTEXTUALLY ADAPTIVE SIGNAL REPRESENTATION USING CONDITIONAL PRINCIPAL COMPONENT ANALYSIS

    E-Print Network [OSTI]

    Rajashekar, Umesh

    is the construction of bases that are adapted to individual signal in- stances. Here we develop a new framework. Index Terms-- Adaptive basis, conditional PCA, self-similarities, image modeling, image representation traditional methods, primarily due to the cost of encoding the indices of selected basis elements

  18. An Adaptable Service-Based Framework for Distributed Product Realization

    E-Print Network [OSTI]

    must be able to incorporate information from all parts of the product lifecycle. It is intended1 An Adaptable Service-Based Framework for Distributed Product Realization Jitesh H. Panchal, Hae-based engineering framework to support distributed product realization. Adaptability is the key strength

  19. Sufficient Conditions for Well-behaved Adaptive Hypermedia Systems

    E-Print Network [OSTI]

    De Bra, Paul

    for the architecture of adaptive hypermedia applications: the Adaptive Hypermedia Application Model (AHAM) [DHW99]. AHAM describes AHS at an abstract level, using an architecture consisting of three parts: · a domain (AE) are discussed in earlier paper [WDD01]. We defined a rule language for AHS, AHAM-CA and proposed

  20. Power Save Adaptation Algorithm for Multimedia Streaming to Mobile Devices

    E-Print Network [OSTI]

    Power Save Adaptation Algorithm for Multimedia Streaming to Mobile Devices Janet Adams Performance. This paper proposes a power save adaptation algorithm for mobile multimedia streaming that aims to increase stages: data reception, decoding and playing and power saving solutions for each of these stages