Powered by Deep Web Technologies
Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Low Dose Radiation Program: Radiation Biology and the Radiation Research  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biology and the Radiation Research Program Biology and the Radiation Research Program The Department of Energy (DOE) and its predecessor organizations, Energy Research and Development Agency (ERDA) and Atomic Energy Commission (AEC), always have been concerned about the health effects of ionizing radiation. Extensive research has been conducted under their sponsorship at all levels of biological organization from molecules to man. Over the past 60 years, studies using every type of radiation source have included exposure to both external radiation sources and to internally deposited radioactive materials. These exposures used different dose patterns and distributions delivered over a wide range of experimental times. This extensive research provided the basis for the new Low Dose Radiation Research Program, linking

2

Low Dose Radiation Research Program: Biologically Based Analysis of Lung  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biologically Based Analysis of Lung Cancer Incidence in a Large Biologically Based Analysis of Lung Cancer Incidence in a Large Canadian Occupational Cohort with Low-LET Low-dose Radiation Exposure, and Comparison with Japanese Atomic Bomb Survivors. Authors: W.D. Hazelton, D. Krewski, S.H. Moolgavkar Lung cancer incidence is analyzed in a large Canadian National Dose Registry (CNDR) cohort with individual annual dosimetry for low-dose occupational exposure to gamma and tritium radiation using several types of multistage models. The primary analysis utilizes the two-stage clonal expansion model (TSCE), with sensitivity analyses using extensions of this model incorporating additional stages. Characteristic and distinct temporal patterns of risk are found for dose-response affecting early, middle, or late stages of carcinogenesis, e.g., initiation with one or more stages,

3

Low Dose Radiation Research Program: Assessing Biological Function of DNA  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Assessing Biological Function of DNA Damage Response Genes Assessing Biological Function of DNA Damage Response Genes Larry H. Thompson Lawrence Livermore National Laboratory Why This Project To understand the relative importance of individual DNA repair and DNA-damage response pathways to the recovery of mammalian cells after exposure to low doses of ionizing radiation (IR). This understanding may lead to better ways of setting limits on human exposure to IR. In spite of the discovery of many mammalian DNA repair genes, our current knowledge of how many of these genes contribute to cellular recovery from IR exposure is quite limited. Project Goals Measure cellular responses at doses in the 5-100 cGy range, which generally cause changes too small to detect in normal, repair-proficient cells Focus on DNA double-strand breaks (DSBs) and DNA oxidative base

4

Radiation physics, biophysics, and radiation biology  

SciTech Connect (OSTI)

The following research programs from the Center for Radiological Research of Columbia University are described: Design and development of a new wall-less ultra miniature proportional counter for nanodosimetry; some recent measurements of ionization distributions for heavy ions at nanometer site sizes with a wall-less proportional counter; a calculation of exciton energies in periodic systems with helical symmetry: application to a hydrogen fluoride chain; electron energy-loss function in polynucleotide and the question of plasmon excitation; a non-parametric, microdosimetric-based approach to the evaluation of the biological effects of low doses of ionizing radiation; high-LET radiation risk assessment at medium doses; high-LET radiobiological effects: increased lesion severity or increased lesion proximity; photoneutrons generated by high energy medical linacs; the biological effectiveness of neutrons; implications for radiation protection; molecular characterization of oncogenes induced by neutrons; and the inverse dose-rate effect for oncogenic transformation by charged particles is LET dependent.

Hall, E.J.

1992-05-01T23:59:59.000Z

5

Radiation physics, biophysics, and radiation biology  

SciTech Connect (OSTI)

Research at the Center for Radiological Research is a multidisciplenary blend of physics, chemistry and biology aimed at understanding the mechanisms involved in the health problems resulting from human exposure to ionizing radiations. The focus is increased on biochemistry and the application of the techniques of molecular biology to the problems of radiation biology. Research highlights of the program from the past year are described. A mathematical model describing the production of single-strand and double-strand breaks in DNA as a function radiation quality has been completed. For the first time Monte Carlo techniques have been used to obtain directly the spatial distribution of DNA moieties altered by radiation. This information was obtained by including the transport codes a realistic description of the electronic structure of DNA. We have investigated structure activity relationships for the potential oncogenicity of a new generation of bioreductive drugs that function as hypoxic cytotoxins. Experimental and theoretical investigation of the inverse dose rate effect, whereby medium LET radiations actually produce an c effect when the dose is protracted, is now at a point where the basic mechanisms are reasonably understood and the complex interplay between dose, dose rate and radiation quality which is necessary for the effect to be present can now be predicted at least in vitro. In terms of early radiobiological damage, a quantitative link has been established between basic energy deposition and locally multiply damaged sites, the radiochemical precursor of DNA double strand breaks; specifically, the spatial and energy deposition requirements necessary to form LMDs have been evaluated. For the first time, a mechanically understood biological fingerprint'' of high-LET radiation has been established. Specifically measurement of the ratio of inter-to intra-chromosomal aberrations produces a unique signature from alpha-particles or neutrons.

Hall, E.J.; Zaider, M.

1993-05-01T23:59:59.000Z

6

Low Dose Radiation Research Program: Original Research Program Plan  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Original Research Program Plan Original Research Program Plan Biological Effects of Low Dose and Dose Rate Radiation Prepared for the Office of Biological and Environmental Research by The Low Dose Radiation Research Program Plan Subcommittee of the Biological and Environmental Research Advisory Committee. II. Table of Contents Face Page Table of Contents Executive Summary Introduction Program Outline Low Dose Radiation vs. Endogenous Oxidative Damage - The Same or Different? Key Question Description Decision Making Value Recommendations and Costs Understanding Biological Responses to Radiation And Endogenous Damage Key Question Description Decision Making Value Recommendations and Costs Thresholds for Low Dose Radiation - Fact or Fiction? Key Question Description Decision Making Value Recommendations and Costs

7

Biological Applications of Synchrotron Radiation:  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biological Applications of Synchrotron Radiation: Biological Applications of Synchrotron Radiation: An Evaluation of the State of the Field in 2002 A BioSync Report. Issued by the Structural Biology Synchrotron users Organization, October, 2002. 2 Table of Contents: Introduction .................................................................................................... 3 Abbreviations .................................................................................................. 5 Executive Summary ......................................................................................... 6 General Concerns ............................................................................................ 9 Synchrotron operations and maintenance ............................................... 9 NSLS, CHESS and the geographical distribution of beam lines

8

Low Dose Radiation Program: 2010 Low Dose Radiation Research Program  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Low Dose Radiation Research Program Investigators' Workshop Low Dose Radiation Research Program Investigators' Workshop »» Event Slide Show More than 150 people attended this year's workshop, held April 12-14 at the Renaissance M Street Hotel in Washington, D.C. In addition to 34 plenary talks and more than 70 poster presentations made by the program investigators, participants heard guest speakers from the National Cancer Institute and from sister low-dose programs in Europe and Japan. Remarks from DOE Dr. Anna Palmisano, Associate Director, Office of Science, Director for Biological and Environmental Research (BER), welcomed the meeting participants, thanked Low Dose Radiation Research Program Manager Dr. Noelle Metting for her leadership, and acknowledged the importance of the Low Dose Program to DOE because of its unique focus and important role. She

9

Low Dose Radiation Program: Links - Agencies with Radiation Regulatory  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Agencies with Radiation Regulatory Concerns and Involvement Agencies with Radiation Regulatory Concerns and Involvement Biological Effects of Low Level Exposures (BELLE) Canadian Nuclear Safety Commission Center for Risk Excellence Health Protection Agency The Health Risks of Extraterrestrial Environments International Commission on Radiation Units and Measurements, Inc. International Commission on Radiological Protection (ICRP) International Radiation Protection Association (IRPA) NASA Space Radiation Program National Academy of Sciences (NAS) Nuclear and Radiation Studies Board National Aeronautics and Space Administration (NASA) NASA OBRR Task Book Publication National Council on Radiation Protection (NCRP) National Institute of Environmental Health Sciences (NIEHS) National Toxicology Program (NTP) Occupational Safety and Health Administration (OSHA)

10

Low Dose Radiation Research Program: Research Institutions  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Institutions Institutions Lovelace Respiratory Research Institute Biological Bases for Radiation Adaptive Responses in the Lung-Lovelace Respiratory Research Institute, Albuquerque, NM USA Contact: Dr. Bobby R. Scott Program Objective Our research focuses on elucidating the biological bases for radiation adaptive responses in the lung and for suppressing lung cancer, and to use the knowledge gained to produce an improved systems-biology-based, risk model for lung cancer induction by low-dose, low linear-energy-transfer (LET) radiation. Research was initiated in October 2009. This research should help foster a new era of low-dose radiation risk/benefit assessment. It will have important implications for possible use of low-dose diagnostic radiation (e.g., X-rays) in cancer therapy. It

11

Low Dose Radiation Research Program: National Laboratories  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

National Laboratories National Laboratories The Low Dose Radiation Program funding encompasses several Scientific Focus Areas (SFAs). The SFAs fund merit-reviewed research at DOE national laboratories. This management approach was created in 2008 by the Office of Biological and Environmental Research (BER) within the U.S. Department of Energy's (DOE's) Office of Science. PNNL's Low Dose Radiation Research Program Scientific Focus Area Linear and Nonlinear Tissue-Signaling Mechanisms in Response to Low Dose and Low Dose-Rate Radiation This program is funded as a U.S. Department of Energy Scientific Focus Area (SFA), and is an integrated cooperative program to understand low dose radiation effects in a complex model system. Coordinating Multidisciplinary Expertise The SFAs are designed to take advantage of the multidisciplinary,

12

Studies of acute and chronic radiation injury at the Biological and Medical Research Division, Argonne National Laboratory, 1970-1992: The JANUS Program Survival and Pathology Data  

SciTech Connect (OSTI)

A research reactor for exclusive use in experimental radiobiology was designed and built at Argonne National Laboratory in the 1960`s. It was located in a special addition to Building 202, which housed the Division of Biological and Medical Research. Its location assured easy access for all users to the animal facilities, and it was also near the existing gamma-irradiation facilities. The water-cooled, heterogeneous 200-kW(th) reactor, named JANUS, became the focal point for a range of radiobiological studies gathered under the rubic of {open_quotes}the JANUS program{close_quotes}. The program ran from about 1969 to 1992 and included research at all levels of biological organization, from subcellular to organism. More than a dozen moderate- to large-scale studies with the B6CF{sub 1} mouse were carried out; these focused on the late effects of whole-body exposure to gamma rays or fission neutrons, in matching exposure regimes. In broad terms, these studies collected data on survival and on the pathology observed at death. A deliberate effort was made to establish the cause of death. This archieve describes these late-effects studies and their general findings. The database includes exposure parameters, time of death, and the gross pathology and histopathology in codified form. A series of appendices describes all pathology procedures and codes, treatment or irradiation codes, and the manner in which the data can be accessed in the ORACLE database management system. A series of tables also presents summaries of the individual experiments in terms of radiation quality, sample sizes at entry, mean survival times by sex, and number of gross pathology and histopathology records.

Grahn, D.; Wright, B.J.; Carnes, B.A.; Williamson, F.S.; Fox, C.

1995-02-01T23:59:59.000Z

13

Request for Travel Funds for Systems Radiation Biology Workshop  

SciTech Connect (OSTI)

The 3rd International Systems Radiation Biology Workshop brought together the major European, US and Japanese research programs on radiation risk as well as selected experts representing systems biological approaches to discuss how the new methodologies could be best exploited for low dose research. A significant part of the workshop was devoted to discussions organised as breakout group sessions. To facilitate discussions number of participants was limited to 60 persons. To achieve the goals of this symposium in this international conference, support from DOE is vital. Hence, this proposal requested support in the amount of $15,000 to cover the travel expenses of international experts and radiation biology scientists from the United States. This supporting mechanism was clearly identified to the selected US participants as a conference support award from the DOE (See attached PDF). The workshop was an outstanding opportunity to strengthen interactions between leading experts in the emerging areas of radiation sciences, and will also provide opportunities for younger scientists to meet with experts and discuss their results. This workshop was designed to endorse active engagement in international collaboration. A major objective of this conference was to effectively communicate research results, in order to ensure that current thinking reflects sound science of radiation biology. Further, this international event addressed the use and success of scientific initiatives in radiation biology for policymakers, standard-setters, and the general public.

Barcellos-Hoff, Mary Helen [NYU School of Medicine

2014-03-22T23:59:59.000Z

14

Atmospheric Radiation Measurement Program  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

3 3 ARM 2003 Tom Ackerman Chief Scientist Tom Ackerman Chief Scientist ARM ARM Atmospheric Radiation Measurement Atmospheric Radiation Measurement WARNING! WARNING! Today is April 1 But that has NO bearing on this message Today is April 1 But that has NO bearing on this message ARM ARM Atmospheric Radiation Measurement Atmospheric Radiation Measurement Two Topics Two Topics * Status of ARM (quick overview) * Science plan - ARM in the next 5 years * Status of ARM (quick overview) * Science plan - ARM in the next 5 years ARM ARM Atmospheric Radiation Measurement Atmospheric Radiation Measurement ARM Status - Science ARM Status - Science * Steadily increasing productivity - Poster session - over 220 posters (may need to do something about submissions next year) - Peer-reviewed articles: 2.5 to 3 per year per

15

Radiation Hazards Program (Minnesota)  

Broader source: Energy.gov [DOE]

These regulations, promulgated by the Department of Health, set allowable radiation standards and mitigation practices, as well as procedures for the transportation of hazardous material.

16

Impact of Radiation Biology on Fundamental Insights in Biology  

DOE R&D Accomplishments [OSTI]

Research supported by OHER [Office of Health and Environmental Research] and its predecessors has as one of its major goals an understanding of the effects of radiation at low doses and dose rates on biological systems, so as to predict their effects on humans. It is not possible to measure such effects directly. They must be predicted from basic knowledge on how radiation affects cellular components such as DNA and membranes and how cells react to such changes. What is the probability of radiation producing human mutations and what are the probabilities of radiation producing cancer? The end results of such studies are radiation exposure standards for workers and for the general population. An extension of these goals is setting standards for exposure to chemicals involved in various energy technologies. This latter problem is much more difficult because chemical dosimetry is a primitive state compared to radiation dosimetry.

Setlow, Richard B.

1982-07-27T23:59:59.000Z

17

LABORATORY OF NUCLEAR MEDICINE AND RADIATION BIOLOGY  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

MEDICINE AND RADIATION BIOLOGY MEDICINE AND RADIATION BIOLOGY 900 VETERAN AVENUE UNIVERSITY OF CALIFORNIA, LOS ANGELES, CALIFORNIA 90024 AND DEPARTMENT OF RADIOLOGICAL SCIENCES UCLA SCHOOL OF MEDICINE, LOS ANGELES, CALIFORNIA 90024 This manuscript is a contribution to the monograph edited by Daniel S. Berman and Dean Mason, entitled "Clinical Nuclear Cardiology". These studies were supported by Contract #DE-AM03-76-SF00012 between the U.S. Department of Energy and the University of California Prepared for the U.S. Department of Energy under Contract #DE-AM03-76-SF00012 POSITRON EMISSION TOMOGRAPHY OF THE HEART Heinrich R. Schelbert, M.D., Michael E. Phelps, Ph.D. and David E. Kuhl, M.D. DISCLAIMER This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the

18

Japan Program - Radiation Effects Research Foundation (RERF)  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Safety Safety Home Sub Offices › Worker Safety & Health Policy › Worker Safety & Health Assistance › Illness & Injury Prevention Programs › International Health Studies › Office of Worker Screening and Compensation Support Mission & Functions › Health & Safety › Worker Safety & Health Policy › Worker Safety & Health Assistance › Illness & Injury Prevention Programs › International Health Studies › Worker Screening and Compensation Support Federal Line Management Oversight of DOE Nuclear Facilities Integrated Safety Management (ISM) A-Z Index Directory OSH Regulatory and Policy Response Line Health Resources Policy and Standards Worker Safety Beryllium Chemical Safety Biological Safety Radiation Safety Rules 10 CFR 707 10 CFR 835

19

Radiation physics, biophysics, and radiation biology. Progress report, December 1, 1991--November 30, 1992  

SciTech Connect (OSTI)

The following research programs from the Center for Radiological Research of Columbia University are described: Design and development of a new wall-less ultra miniature proportional counter for nanodosimetry; some recent measurements of ionization distributions for heavy ions at nanometer site sizes with a wall-less proportional counter; a calculation of exciton energies in periodic systems with helical symmetry: application to a hydrogen fluoride chain; electron energy-loss function in polynucleotide and the question of plasmon excitation; a non-parametric, microdosimetric-based approach to the evaluation of the biological effects of low doses of ionizing radiation; high-LET radiation risk assessment at medium doses; high-LET radiobiological effects: increased lesion severity or increased lesion proximity; photoneutrons generated by high energy medical linacs; the biological effectiveness of neutrons; implications for radiation protection; molecular characterization of oncogenes induced by neutrons; and the inverse dose-rate effect for oncogenic transformation by charged particles is LET dependent.

Hall, E.J.

1992-05-01T23:59:59.000Z

20

Radiation physics, biophysics, and radiation biology. Progress report, December 1, 1992--November 30, 1993  

SciTech Connect (OSTI)

Research at the Center for Radiological Research is a multidisciplenary blend of physics, chemistry and biology aimed at understanding the mechanisms involved in the health problems resulting from human exposure to ionizing radiations. The focus is increased on biochemistry and the application of the techniques of molecular biology to the problems of radiation biology. Research highlights of the program from the past year are described. A mathematical model describing the production of single-strand and double-strand breaks in DNA as a function radiation quality has been completed. For the first time Monte Carlo techniques have been used to obtain directly the spatial distribution of DNA moieties altered by radiation. This information was obtained by including the transport codes a realistic description of the electronic structure of DNA. We have investigated structure activity relationships for the potential oncogenicity of a new generation of bioreductive drugs that function as hypoxic cytotoxins. Experimental and theoretical investigation of the inverse dose rate effect, whereby medium LET radiations actually produce an c effect when the dose is protracted, is now at a point where the basic mechanisms are reasonably understood and the complex interplay between dose, dose rate and radiation quality which is necessary for the effect to be present can now be predicted at least in vitro. In terms of early radiobiological damage, a quantitative link has been established between basic energy deposition and locally multiply damaged sites, the radiochemical precursor of DNA double strand breaks; specifically, the spatial and energy deposition requirements necessary to form LMDs have been evaluated. For the first time, a mechanically understood ``biological fingerprint`` of high-LET radiation has been established. Specifically measurement of the ratio of inter-to intra-chromosomal aberrations produces a unique signature from alpha-particles or neutrons.

Hall, E.J.; Zaider, M.

1993-05-01T23:59:59.000Z

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Radiation Control Program and Radiation Control Act (Nebraska)  

Broader source: Energy.gov [DOE]

This statute authorizes the state to implement a regulatory program for sources of radiation, and contains rules for the Department, licensing and registration, and taxation of radioactive materials.

22

Low Dose Radiation Program: Links - Organizations Conducting Radiation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Conducting Low Dose Radiation Research Conducting Low Dose Radiation Research DOE Low Dose Radiation Research Program DoReMi Integrating Low Dose Research High Level Expert Group (HLEG) on European Low Dose Risk Research Multidisciplinary European Low Dose Initiative (MELODI) RISC-RAD Radiosensitivity of Individuals and Susceptibility to Cancer induced by Ionizing Radiation United States Transuranium & Uranium Registries Organizations Conducting other Radiation Research Argonne National Laboratory (ANL) Armed Forces Radiology Research Institute (AFRRI) Atmospheric Radiation Measurement (ARM) Program Brookhaven National Laboratory (BNL) Center for Devices and Radiological Health (CDRH) Central Research Institute of Electric Power Industry (CRIEPI) Colorado State University Columbia University

23

Radiation Safety Program Annual Review  

E-Print Network [OSTI]

........................................................................10 AREA RADIATION SURVEYS AND CONTAMINATION CONTROL...........................................11.....................................................................................................13 RADIOACTIVE WASTE MANAGEMENT meetings of the Radiation Safety Committee where new users and uses of radioactive materials, radiation

Lyubomirsky, Ilya

24

Order Module--RADIATION PROTECTION PROGRAMS GUIDE  

Broader source: Energy.gov [DOE]

The familiar level of this module is designed to provide the basic information related to DOEG 441.1-1C, Radiation Protection Programs Guide, as required in DOE-STD-1174-2003, Radiation Protection...

25

COLUMBIA UNIVERSITY Radiation Safety Program  

E-Print Network [OSTI]

DDE ESTIMATED DOSE FROM CONCEPTION TO DECLARATION: DDE Radiation Safety Officer Signature for increased protection from ionizing radiation for declared pregnant radiation workers. The radiation dose of the occupational dose limit of 50 mSv (5.0 rem). The CPMC Radiation Safety Office will provide education

Jia, Songtao

26

Low Dose Radiation Research Program: What's New Archive  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

What's New What's New Tony Brooks Chosen As Lauriston S. Taylor Lecturer Congratulations to radiation biologist Dr. Antone "Tony" Brooks, a consultant to the Pacific Northwest National Laboratory's Low Dose Radiation Research Program, on his selection to give the 36th Lauriston S. Taylor Lecture at the Annual Meeting of the National Council on Radiation Protection and Measurements (NCRP). Brooks is former chief scientist for the U.S. Department of Energy's Low Dose Radiation Research Program. His lecture, titled "From the Field to the Laboratory and Back: The What Ifs, Wows, and Who Cares of Radiation Biology," will be a featured presentation at the meeting, which will be held March 12 and 13, 2012, at the Hyatt Regency Bethesda, Bethesda, Maryland.

27

Pre-Clinical Radiation Biology and Medical Physics Divisions  

E-Print Network [OSTI]

the uncertainties". Consider the uncertainties in delivering and measuring a dose of radiation to a certain tissue; There are uncertainties inherent in the dose measurement and calculation process Estimates of these uncertainties (forPre-Clinical Radiation Biology and Medical Physics Divisions Department of Radiation Oncology Tom

28

Nevada Test Site Radiation Protection Program  

SciTech Connect (OSTI)

Title 10 Code of Federal Regulations (CFR) 835, 'Occupational Radiation Protection', establishes radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of U.S. Department of Energy (DOE) activities. 10 CFR 835.101(a) mandates that DOE activities be conducted in compliance with a documented Radiation Protection Program (RPP) as approved by DOE. This document promulgates the RPP for the Nevada Test Site (NTS), related (onsite or offsite) DOE National Nuclear Security Administration Nevada Site Office (NNSA/NSO) operations, and environmental restoration offsite projects.

Radiological Control Managers' Council, Nevada Test Site

2007-08-09T23:59:59.000Z

29

Low Dose Radiation Program: Links - Online Literature  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Online Literature Online Literature Journals, Books and other Publications Armed Forces Radiobiology Research Institute Chornobyl Center for Nuclear Safety Radioactive Waste and Radioecology "Insight" Magazine Central Research Institute of the Electric Power Industry (CRIEPI) News: Aiming at an information center on low dose radiation research Health Physics International Journal of Radiation Biology Iranian Journal of Radiation Research Journal of Radiological Protection National Council on Radiation Protection and Measurements Radiation Research U.S. Department of Energy (DOE) Information Bridge Reports Animal Cancer Tests and Human Cancer Risk Assessment: A Broad Perspective Effects of Ionizing Radiation: Atomic Bomb Survivors and Their Children (1945-1995) Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR

30

Low Dose Radiation Research Program: DOE Lowdose Radiation Program Workshop  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Using a Low LET Electron Microbeam to Investigate Non-Targeted Using a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation. Authors: William F. Morgan1 and Marianne B. Sowa2 Institutions: 1Radiation Oncology Research Laboratory, University of Maryland, Baltimore MD 21201 2 Chemical Structure and Dynamics, Pacific Northwest National Laboratory, Richland WA 99352 We have recently installed a low LET electron microbeam that generates energetic electrons to mimic radiation damage from gamma and x-ray sources. It has been designed such that high-energy electrons deposit energy in a pre-selected subset of cells leaving neighboring cells unirradiated (Figure 1). In this way it is possible to examine non-targeted effects associated with low dose radiation exposure including induced genomic instability and

31

Occupational Radiation Protection Program (10 CFR 835)  

Broader source: Energy.gov [DOE]

The occupational radiation protection program is governed by the Rule, specified as 10 CFR 835. The requirements given in 10 CFR 835 are matters of law, punishable by civil and criminal penalties.

32

Low Dose Radiation Program: Workshops, Proceedings, Abstracts and Programs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Workshops, Proceedings, Abstracts and Programs Workshops, Proceedings, Abstracts and Programs UPDATE: Investigators' Workshop Postponed The annual Low Dose Radiation Research Program Investigators' Workshop typically held in April or May has been postponed until next year. Please keep checking the website for updates. 2010 The 2010 DOE Low Dose Radiation Research Investigators' Workshop was held April 12-14, 2010, at the Renaissance M Street Hotel in Washington, D.C. In addition to 34 plenary talks and more than 70 poster presentations made by the program investigators, participants heard guest speakers from the National Cancer Institute and from sister low-dose programs in Europe and Japan. See link for investigators' abstracts. 2009 The DOE Low Dose Radiation Research Investigators' Workshop VIII was held

33

Low Dose Radiation Research Program: Adaptive Response of Mouse Skin  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Ionizing Radiation: Induction of NF-κB, MnSOD, 14-3-3ζ and Cyclin B1 Authors: Jian Jian Li, Kazi M. Ahmed, Ming Fan, Shaozhong Dong, Douglas R. Spitz, and Cheng-Rong Yu Institutions: Division of Molecular Radiobiology, Purdue University School of Health Sciences, West Lafayette, Indiana; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa; Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland Gene expression profiles demonstrate that a group of key stress-responsive genes are associated with radiation exposure and may contribute to cellular

34

Low Dose Radiation Research Program: Optimizing the Scientific, Regulatory  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Optimizing the Scientific, Regulatory and Social Impact of the DOE Optimizing the Scientific, Regulatory and Social Impact of the DOE Low Dose Radiation Research Program. Authors: Antone L.Brooks, Richard J. Bull, Lezlie A. Couch. Institutions: Washington State University Tri-Cities The purpose of this project is to provide scientific, technical, and organizational support to optimize the impact of the DOE Low Dose Radiation Research Program. This project will serve as a focal point for collection and dissemination of scientific information from the scientists funded in the Program to the U.S. Department of Energy (DOE), the regulatory agencies, and the public. The project will be responsible for analysis of the scientific information in the broader context of biomedical research and will provide this information to the Office of Biological Research

35

CRAD, Occupational Radiation Protection Program - December 4, 2012 |  

Broader source: Energy.gov (indexed) [DOE]

Occupational Radiation Protection Program - December 4, 2012 Occupational Radiation Protection Program - December 4, 2012 CRAD, Occupational Radiation Protection Program - December 4, 2012 December 4, 2012 Occupational Radiation Protection Program Inspection Criteria, Approach, and Lines of Inquiry (HSS CRAD 45-35, Rev. 1) This document provides an overview of the Criteria, Activities, and Lines of Inquiry that will be used to collect information to evaluate occupational radiation protection programs against DOE policy, standards, and regulatory requirements. The approach includes evaluation of essential programmatic elements of radiation protection programs with additional emphasis on implementation of the core functions of integrated safety management. CRAD, Occupational Radiation Protection Program - December 4, 2012

36

SSRL SMB Program | Stanford Synchrotron Radiation Lightsource  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

SMB Program SMB Program SSRL Structural Molecular Biology program The SSRL Structural Molecular Biology program operates as a integrated resource and has three primary areas (or cores) of technological research and development and scientific focus: macromolecular crystallography (MC), x-ray absorption spectroscopy (XAS), and small angle x-ray scattering/diffraction (SAXS). Central to the core technological developments in all three of these areas is the development and utilization of improved detectors and instrumentation, especially to be able to take maximum advantage of the increasingly high brightness of SSRL's storage ring (SPEAR3). There is also research and development in new methods - in techniques and instrumentation development and deployment. Included is the use of enhanced computing and data

37

Low Dose Radiation Program: Workshop VI Abstracts  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Workshop VI Principal Investigator and Abstracts Workshop VI Principal Investigator and Abstracts Anderson, Carl Whole Genome Analysis of Functional Protein Binding Sites and DNA Methylation: Application to p53 and Low Dose Ionizing Radiation. Averbeck, Dietrich Cellular Responses at Low Doses of Ionizing Radiation. Azzam, Edouard Adaptive Responses to Low Dose/Low Dose-Rate ?-Rays in Normal Human Fibroblasts: The Role of Oxidative Metabolism. Bailey, Susan The Role of Telomere Dysfunction in Driving Genomic Instability. Balajee, Adayabalam Low Dose Radiation Induced DNA Damage Signaling and Repair Responses in Human 3-Dimensional Skin Model System. Barcellos-Hoff, Mary Helen Imaging Bioinformatics for Mapping Multidimensional Responses. Barcellos-Hoff, Mary Helen Biological Response to Radiation Mediated through the Microenvironment and

38

BioDoser: Improved dose-estimation software for biological radiation dosimetry  

Science Journals Connector (OSTI)

This paper introduces a software program that was developed with the aims to improve the efficiency and veracity of calibration curve fitting and data processing in radiation biological dosimetry and other biological experiments, and which is termed BioDoser. BioDoser uses least squares and loop testing of monotonicity method and algorithm of non-uniformed confidence interval. In addition, this program enables integration of multiple different biomarkers typically used in biological dosimetry. These include partial body exposure, minimum number of cells to be analyzed, G function correction modules that are helpful in dose estimation when using chromosome aberration frequencies, micronucleus rate, comet assay and other biological methods. The software is freely available at http://bit.ly/kKBSNR.

Hong Wang; Qiang Liu; Dandan Wan; Jian Xiang; Liqing Du; Yan Wang; Jia Cao; Yue Fu; Feiyue Fan; Markus Hecker

2012-01-01T23:59:59.000Z

39

CRAD, Occupational Radiation Protection Program- December 4, 2012  

Broader source: Energy.gov [DOE]

Occupational Radiation Protection Program Inspection Criteria, Approach, and Lines of Inquiry (HSS CRAD 45-35, Rev. 1)

40

Low Dose Radiation Research Program: Universities  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Universities Universities | Duke University | Loma Linda University | Northwestern University | University of Chicago | University of California Davis | Northwestern University University of Chicago University of California Davis Effects of Low Dose Irradiation on NF-κB Signaling Networks and Mitochondria Principal Investigator: Dr. Gayle Woloschak DOE Low Dose Research Program Projects Low dose-low dose rate irradiation leads to long term changes in numbers of mitochondria and mitochondrial genomes - Principal Investigator: Gayle Woloschak, Professor, Department of Radiation Oncology, Northwestern University, Chicago, IL, USA NF-κB-mediated pro-survival network in low dose radiation-induced adaptive protection - Principal Investigator: Jian Jian Li, Professor, Department of Radiation Oncology, University of California Davis, Davis,

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Chemical and biological nonproliferation program. FY99 annual report  

SciTech Connect (OSTI)

This document is the first of what will become an annual report documenting the progress made by the Chemical and Biological Nonproliferation Program (CBNP). It is intended to be a summary of the program's activities that will be of interest to both policy and technical audiences. This report and the annual CBNP Summer Review Meeting are important vehicles for communication with the broader chemical and biological defense and nonproliferation communities. The Chemical and Biological Nonproliferation Program Strategic Plan is also available and provides additional detail on the program's context and goals. The body of the report consists of an overview of the program's philosophy, goals and recent progress in the major program areas. In addition, an appendix is provided with more detailed project summaries that will be of interest to the technical community.

NONE

2000-03-01T23:59:59.000Z

42

Low Dose Radiation Research Program: Communicating the Science of the Low  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Communicating the Science of the Low Dose Radiation Research Program Communicating the Science of the Low Dose Radiation Research Program Authors: John S. Wassom, Elizabeth T. Owens, Sheryl A. Martin, Amy K. Wolfe, Margaret K. Lyday,* and Susan L. Dimmick** Institutions: Oak Ridge National Laboratory, *Keener Communications, and the **University of Tennessee Graduate School of Medicine. Summary The project team developed a communications plan based on an explicit communications strategy. The plan presents a set of strategic goals, identifies categories of stakeholders relevant to the program, and suggests methods that can be used to achieve strategic goals and reach targeted stakeholders. Context is key to the communication plan. Providing contextual information about low dose radiation, radiation biology, and Low Dose Radiation

43

Bibliography of marine radiation ecology prepared for the Seabed Program  

SciTech Connect (OSTI)

References on the effects of ionizing radiation on aquatic organisms have been obtained from a number of sources. Many were obtained from reviews and other publications. Although the primary purpose of preparing this bibliography was to obtain information related to the nuclear wastes Seabed Disposal Biology Program of Sandia Laboratories, freshwater organisms are included as a matter of convenience and also with the belief that such a bibliography would be of interest to a wider audience than that restricted to the Seabed Program. While compilation of a list in an area broad in scope is often somewhat arbitrary, an attempt was made to reference publications that were related to field or laboratory studies of wild species of plants and animals with respect to radiation effects. Complete information concerning each reference are provided without excessive library search. Since one often finds references listed in the literature that are incompletely cited, it was not always possible to locate the reference for verification or completion of the citation. Such references are included where they appeared to be of possible value. When known, a reference is followed with its Nuclear Science Abstract designation, or rarely other abstract sources. Those desiring additional information should check Nuclear Science Abstracts utilizing the abstract number presented or other abstracting sources. In addition, the language of the article, other than English, is given when it is known to me.

Schultz, V.S.

1980-02-01T23:59:59.000Z

44

One Giant Leap for Radiation Biology? | Advanced Photon Source  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

What's in the Cage Matters in Iron Antimonide Thermoelectric Materials What's in the Cage Matters in Iron Antimonide Thermoelectric Materials Novel Experiments on Cement Yield Concrete Results Watching a Glycine Riboswitch "Switch" Polyamorphism in a Metallic Glass Under Pressure, Vanadium Won't Turn Down the Volume Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed One Giant Leap for Radiation Biology? MAY 2, 2007 Bookmark and Share Image overlay of transmission electron microscopy, light microscopy, and x-ray fluorescence microprobe analyses of D. radiodurans. Average abundance of manganese (blue, green, and pink) and iron (red) are shown within a single D. radiodurans diplococcus. The field of radiobiology is built upon the premise that radiation is

45

Order Module--RADIATION PROTECTION PROGRAMS GUIDE | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

RADIATION PROTECTION PROGRAMS GUIDE RADIATION PROTECTION PROGRAMS GUIDE Order Module--RADIATION PROTECTION PROGRAMS GUIDE The familiar level of this module is designed to provide the basic information related to DOE G 441.1-1C, Radiation Protection Programs Guide, as required in DOE-STD-1174-2003, Radiation Protection Functional Area Qualification Standard, December 2003. Completion of this module also meets certain requirements associated with the DOE Facility Representative Program and the DOE Intern Program. The information contained in this module addresses specific requirements and as such does not include the entire text of the source document. Before continuing, you should obtain a copy of the Order. Copies of the DOE Directives are available at http://www.directives.doe.gov/ or through the course manager. In March

46

Algal Biology Program at Los Alamos gets a star  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Algal Biology Program gets a star Algal Biology Program gets a star Algal Biology Program at Los Alamos gets a star Richard Sayre, one of the nation's top specialists in algae and energy-producing plant research, has joined LANL to help boost cutting-edge research. October 11, 2011 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials.

47

LABORATORY OF NUCLEAR MEDICIhF ARD RADIATION BIOLOGY  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

MEDICIhF ARD RADIATION BIOLOGY MEDICIhF ARD RADIATION BIOLOGY . - UNIVERSITY OF CALIFORNIA, LOS ANGELES, CALIFORMA 90024 Ah" DEPARTXENT OF RADIOLOGY UCLA SCHOOL OF MEDICINE, LOS ANGELES, CALIFORNIA 90024 This work was p a r t i a l l y supported by ERDA Contract gEY-76-C-03-0012 and N I H g r a n t 7-R01-GM-24839-01. Prepared for U.S. Energy Research and Development Administrat ion under C o n t r a c t gEY-76-C-03-0012 ECAT: A New Computerized Tomographic Imaging System for Positron-Emitting Michael E. Phelps, Edward J . Hoffman Sung-Cheng Huang and David E . Kuhl Radiopharmaceuticals DISCLAIMER This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency Thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal

48

Radiation safety and protection in US dental hygiene programs  

SciTech Connect (OSTI)

A survey of radiation safety and protection measures used by programs teaching dental hygiene indicated some areas for concern. No barriers or radiation shieldings were used between operator and patient in four programs. Radiation monitoring devices were not worn by faculty operators in 16% of the programs. Fewer than half of the programs used thyroid shields for patients on a routine basis. Insufficient filtration for the kilovolt peak employed was used by 14% of the programs, and for 19% more the filtration was unknown or unspecified. Three programs used closed cones. Rectangular collimation was not used at all by 63% of the programs, and only 20% used E speed film routinely. Quality assurance for equipment maintenance and for film processing were in place at only 54% and 49% of the programs, respectively.

Farman, A.G.; Hunter, N.; Grammer, S.

1986-07-01T23:59:59.000Z

49

hspthe harvard sussex program on chemical and biological weapons (CBW)  

E-Print Network [OSTI]

hspthe harvard sussex program on chemical and biological weapons (CBW) Resource Guide of the use of chemical weapons Never to develop, produce, otherwise acquire, stockpile or retain chemical weapons Never to assist, encourage or induce, in any way, anyone to engag To destroy chemical weapons

Sussex, University of

50

Low Dose Radiation Research Program: Mary Helen Barcellos-Hoff - 2003  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

DOE Low Dose Radiation Program Workshop IV DOE Low Dose Radiation Program Workshop IV Abstract Title: TGF-β Protects Human Mammary Epithelial Cells from Radiation-Induced Centrosome Amplification Authors: Mary Helen Barcellos-Hoff, Bahram Parvin, Anna C. Erickson and Rishi Gupta Institutions: Department of Cell and Molecular Biology, Life Sciences Division, Ernest Orlando Lawrence, Berkeley National Laboratory, Berkeley, California In recent studies we have shown that ionizing radiation (IR), a known carcinogen of human and murine mammary gland, compromises human mammary epithelial cell (HMEC) polarity and multicellular organization in a manner characteristic of neoplastic progression through a heritable, non-mutational mechanism (1). Thus, when all cells are irradiated with a significant dose (2 Gy), the daughters of irradiated cells lose their

51

Low Dose Radiation Research Program: Image Gallery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Image Gallery Image Gallery These are images, photographs, and charts presented or developed for Low Dose Radiation Research Investigators’ Meetings. They may be used for presentations or reports. To save, right click on the picture, then choose "Save picture as." U.S. annual per-capita effective radiation dose from various sources for 1980. various sources 1980 Enlarge Image. U.S. annual per-capita effective radiation dose from various sources for 2006. various sources 2006 Enlarge Image. U.S. annual per-capita effective radiation dose from man-made sources in the United States for 2006. man-made 2006 Enlarge Image. Ionizing Radiation Dose Ranges showing the wide range of radiation doses that humans experience (Rem) Enlarge Image. Ionizing Radiation Dose Ranges showing the wide range of radiation doses that humans experience

52

Current Status and Recommendations for the Future of Research, Teaching, and Testing in the Biological Sciences of Radiation Oncology: Report of the American Society for Radiation Oncology Cancer Biology/Radiation Biology Task Force, Executive Summary  

SciTech Connect (OSTI)

In early 2011, a dialogue was initiated within the Board of Directors (BOD) of the American Society for Radiation Oncology (ASTRO) regarding the future of the basic sciences of the specialty, primarily focused on the current state and potential future direction of basic research within radiation oncology. After consideration of the complexity of the issues involved and the precise nature of the undertaking, in August 2011, the BOD empanelled a Cancer Biology/Radiation Biology Task Force (TF). The TF was charged with developing an accurate snapshot of the current state of basic (preclinical) research in radiation oncology from the perspective of relevance to the modern clinical practice of radiation oncology as well as the education of our trainees and attending physicians in the biological sciences. The TF was further charged with making suggestions as to critical areas of biological basic research investigation that might be most likely to maintain and build further the scientific foundation and vitality of radiation oncology as an independent and vibrant medical specialty. It was not within the scope of service of the TF to consider the quality of ongoing research efforts within the broader radiation oncology space, to presume to consider their future potential, or to discourage in any way the investigators committed to areas of interest other than those targeted. The TF charge specifically precluded consideration of research issues related to technology, physics, or clinical investigations. This document represents an Executive Summary of the Task Force report.

Wallner, Paul E., E-mail: pwallner@theabr.org [21st Century Oncology, LLC, and the American Board of Radiology, Bethesda, Maryland (United States); Anscher, Mitchell S. [Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia (United States); Barker, Christopher A. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Bassetti, Michael [Department of Human Oncology, University of Wisconsin Carbone Cancer Center, Madison, Wisconsin (United States); Bristow, Robert G. [Departments of Radiation Oncology and Medical Biophysics, Princess Margaret Cancer Center/University of Toronto, Toronto, Ontario (Canada); Cha, Yong I. [Department of Radiation Oncology, Norton Cancer Center, Louisville, Kentucky (United States); Dicker, Adam P. [Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Formenti, Silvia C. [Department of Radiation Oncology, New York University, New York, New York (United States); Graves, Edward E. [Departments of Radiation Oncology and Radiology, Stanford University, Stanford, California (United States); Hahn, Stephen M. [Department of Radiation Oncology, University of Pennsylvania (United States); Hei, Tom K. [Center for Radiation Research, Columbia University, New York, New York (United States); Kimmelman, Alec C. [Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (United States); Kirsch, David G. [Department of Radiation Oncology, Duke University, Durham, North Carolina (United States); Kozak, Kevin R. [Department of Human Oncology, University of Wisconsin (United States); Lawrence, Theodore S. [Department of Radiation Oncology, University of Michigan (United States); Marples, Brian [Department of Radiation Oncology, Oakland University, Oakland, California (United States); and others

2014-01-01T23:59:59.000Z

53

Low Dose Radiation Research Program: Low Dose Radiation Effects in  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Radiation Effects in Differentiating Human Lens Cells Radiation Effects in Differentiating Human Lens Cells E.A. Blakely1, M.P. McNamara1, P.Y. Chang1, K.A. Bjornstad1, D. Sudar1, and A.C. Thompson2 1Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California; 2Advanced Light Source Division, Lawrence Berkeley National Laboratory, Berkeley, California. Introduction The human lens is one of the most radiosensitive organs of the body. Cataract, the opacification of the lens, is a late-appearing response to radiation damage. There are few data available on the late radiation effects of exposure in space flight to charged particle beams, the most prevalent of which are protons. Basic research in this area is needed to integrate the responses of both critical and other representative tissues

54

Low Dose Radiation Research Program: Research Program Workshop I Abstracts  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Genetic Factors Affecting Susceptibility to Low-Dose Radiation Genetic Factors Affecting Susceptibility to Low-Dose Radiation William F. Morgan and John H.J. Petrini Radiation Oncology Research Laboratory, University of Maryland at Baltimore, Baltimore, MD Summary: The goal of our application is to improve the scientific basis for understanding potential risks to the population from low dose radiation exposure based on potential genetic differences that may modulate an individual's sensitivity to low doses of radiation. Abstract: The goal of this application is to improve the scientific basis for understanding potential risks to the population from low dose radiation exposure. We propose to address specific genetic factors that affect individual susceptibility to low dose radiation and ask the question do genetic differences exist that make some individuals more sensitive to

55

BIOTECHNOLOGY CERTIFICATE PROGRAM The Biotechnology Certificate Program is open to all FAU Biology and Chemistry Students  

E-Print Network [OSTI]

BIOTECHNOLOGY CERTIFICATE PROGRAM The Biotechnology Certificate Program is open to all FAU Biology in biotechnology. In addition to the requirements for the baccalaureate degree sought, students must complete credits) B- PCB 3063 Genetics (4 credits) C- BSCL4403 Biotechnology I laboratory (2 credits) B- BSCL4405

Fernandez, Eduardo

56

Low Dose Radiation Research Program: About  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

About About Background. Extensive research on the health effects of radiation using standard epidemiological and toxicological approaches has been done for decades to characterize responses of populations and individuals to high radiation doses, and to set exposure standards to protect both the public and the workforce. These standards were set using models that extrapolated from the cancers observed following exposure to high doses of radiation to predicted, but not measurable, changes in cancer frequency at low radiation doses. The use of models was necessary because of our inability to detect changes in cancer incidence following low doses of radiation. Historically, the predominant approach has been the Linear-no-Threshold model (see Wikipedia entry) and collective dose concept that assumes each unit of radiation, no

57

Low Dose Radiation Research Program: Frequencies of Radiation-Induced  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Frequencies of Radiation-Induced Chromosome Interchanges and Frequencies of Radiation-Induced Chromosome Interchanges and Randomness of Chromosome Territory Locations Relative to One Another. Authors: RK Sachs,§ MN Cornforth,‡ KM Greulich-Bode,* L Hlatky, and DJ Brenner|| Institutions: §Department of Mathematics, University of California, ‡University of Texas Medical Branch, *Department of Skin Carcinogenesis, German Cancer Research Center DFCI, Harvard Medical School, ||Center for Radiological Research, Columbia University. Leukemogenesis, and perhaps carcinogenesis in general, often involves specific chromosome translocations. Radiation-induced chromosome translocation frequencies are strongly influenced by how close participating chromosomes are to one another in an interphase cell nucleus. We sought to determine whether chromosomes in human peripheral blood

58

Yucca Mountain biological resources monitoring program; Annual report FY92  

SciTech Connect (OSTI)

The US Department of Energy (DOE) is required by the Nuclear Waste Policy Act of 1982 (as amended in 1987) to study and characterize Yucca Mountain as a potential site for a geologic repository for high-level nuclear waste. During site characterization, the DOE will conduct a variety of geotechnical, geochemical, geological, and hydrological studies to determine the suitability of Yucca Mountain as a potential repository. To ensure that site characterization activities (SCA) do not adversely affect the environment at Yucca Mountain, an environmental program has been implemented to monitor and mitigate potential impacts and ensure activities comply with applicable environmental regulations. This report describes the activities and accomplishments of EG&G Energy Measurements, Inc. (EG&G/EM) during fiscal year 1992 (FY92) for six program areas within the Terrestrial Ecosystem component of the YMP environmental program. The six program areas are Site Characterization Effects, Desert Tortoises, Habitat Reclamation, Monitoring and Mitigation, Radiological Monitoring, and Biological Support.

NONE

1993-02-01T23:59:59.000Z

59

Yucca Mountain Biological Resources Monitoring Program; Annual report, FY91  

SciTech Connect (OSTI)

The US Department of Energy (DOE) is required by the Nuclear Waste Policy Act of 1982 (as amended in 1987) to study and characterize Yucca Mountain as a possible site for a geologic repository for high-level nuclear waste. During site characterization, the DOE will conduct a variety of geotechnical, geochemical, geological, and hydrological studies to determine the suitability of Yucca Mountain as a repository. To ensure that site characterization activities (SCA) do not adversely affect the Yucca Mountain area, an environmental program has been implemented to monitor and mitigate potential impacts and to ensure that activities comply with applicable environmental regulations. This report describes the activities and accomplishments during fiscal year 1991 (FY91) for six program areas within the Terrestrial Ecosystem component of the YMP environmental program. The six program areas are Site Characterization Activities Effects, Desert Tortoises, Habitat Reclamation, Monitoring and Mitigation, Radiological Monitoring, and Biological Support.

NONE

1992-01-01T23:59:59.000Z

60

Low Dose Radiation Research Program: Earlier Events  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Earlier Events Earlier Events 2000 | 2001 | 2002 | 2003 | 2004 April 2000 Ionizing Radiation Science and Protection in the 21st Century, NCRP, April 5-6, Arlington, VA. RADIATION RESEARCH 2000, Association for Radiation Research, April 10-12, Bristol, UK. Florida Chapter of the Health Physics Society Spring 2000 Meeting, Gainesville, FL, April 13-14. 47th Annual Meeting of the Radiation Research Society, April 29-May 3, Albuquerque, NM. May 2000 IRPA-10 International Congress 2000, May 14-19, Hiroshima, Japan. IRPA-10 Secretariat, c/o Japan Convention Services, Inc., Nippon Press Center Building, 2-2-1, Uchisaiwai-cho, Chiyoda-ku, Tokyo 100, Japan. Phone: 81-3-3508-1214. Fax: 81-3-3508-0820. irpa10@convention.jp. 4th International Non-Ionizing Radiation Workshop, May 22-25, Kyoto,

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Low Dose Radiation Research Program: Induction of Genomic Instability in  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Induction of Genomic Instability in vivo by Low Doses of 137Cs y Induction of Genomic Instability in vivo by Low Doses of 137Cs y rays, Authors: K. Rithidech1, E.B. Whorton2, M. Tungjai1, E. Ar-Bab1, S.R. Simon1, M. Tawde3 and C.W. Anderson3. Institutions: 1Pathology Department, Stony Brook University, NY 11794-8691, USA, 2University of Texas Medical Branch at Galveston, TX 77550-1047,3Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000. Information on potential health hazards of radiation at doses below or equal to the level traditionally requiring human radiation protection (less than or equal to 10 cGy) is currently lacking. It is therefore important to characterize early and subsequent in vivo biological response induced by low doses of ionizing radiation because such data should provide information that can help determine whether radiation at this dose level

62

Low Dose Radiation Research Program: Research Highlights - Health Physics  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Health Physics Special Issue Features Contributions by Low Dose Health Physics Special Issue Features Contributions by Low Dose Investigators Health Physics The March 2011 special issue of Health Physics highlights the Victor Bond Workshop held May 2-5, 2010, in Richland, Wash. The workshop honored the late Dr. Victor (Vic) Bond for his lifetime achievement in the radiation sciences. Dr. Bond's research resulted in numerous influential scientific papers that contributed greatly to the understanding of radiation effects in biological systems. The workshop attracted internationally recognized experts in biophysics, experimental radiation biology, epidemiology, and risk assessment to discuss issues of low-dose risk. Participants included current and previously funded U.S. Department of Energy Low Dose Radiation Research

63

SUBCHAPTER F--RADIATION PROTECTION PROGRAMS PART 190--ENVIRONMENTAL RADI-  

E-Print Network [OSTI]

5 SUBCHAPTER F--RADIATION PROTECTION PROGRAMS PART 190--ENVIRONMENTAL RADI- ATION PROTECTION of 1954, as amended; Reorganization Plan No. 3, of 1970. SOURCE: 42 FR 2860, Jan. 13, 1977, unless to radiation doses received by members of the public in the general environment and to radioactive materials

64

Biological equivalent dose studies for dose escalation in the stereotactic synchrotron radiation therapy clinical trials  

E-Print Network [OSTI]

at the European Synchrotron Radiation Facility ESRF . To estimate the possible risks, the doses receivedBiological equivalent dose studies for dose escalation in the stereotactic synchrotron radiation technique a radiation dose enhancement specific to the tumor is obtained. The tumor is loaded with a high

Boyer, Edmond

65

Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away  

E-Print Network [OSTI]

in extrapolating radiation risk estimates from epidemi- ologically accessible doses down to very low doses where) and for assessing the risk from a low-dose exposure to a carcinogen such as ionizing radiation, where only a smallBiological effects in unirradiated human tissue induced by radiation damage up to 1 mm away Oleg V

66

Low Dose Radiation Research Program: The Role of the Number and Spacing of  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Program Workshop I Program Workshop I November 10-12, 1999, Washington, D.C. The Role of the Number and Spacing of Electron Tracks on the Consequences of Low Dose Irradiation Leslie A. Braby and J. R. Ford Nuclear Engineering, Texas A&M University, 129 Zachry, College Station, Texas. Summary: Biological mechanisms, which may influence the health risks resulting from very low dose radiation exposures, will be investigated using a collimated beam of electrons to simulate the irradiation patterns occurring with low dose exposures. Abstract: Ionizing radiation produces a variety of free radicals and chemical products that react to produce the same types of oxidative damage in a mammalian cell as produced by the normal metabolic activity of the cell. However, the damage produced by radiation is distributed differently

67

Low Dose Radiation Research Program: William F. Morgan  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

William F. Morgan William F. Morgan Pacific Northwest National Laboratory PO Box 999 Richland, Washington About this Project Projects Using a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation. Optimizing the Scientific, Regulatory, and Societal Impact of the DOE Low Dose Radiation Research Program A Mechanistic Study of the Radiation Quality Dependence of Bystander Effects in Human Cells. Genetic Factors Affecting Susceptibility to Low-Dose Radiation Mechanisms of Adaptive Responses and Genomic Instability Induced by Low Dose/ Low Dose Rate Radiation Technical Abstracts 2006 Workshop: Using a Low-LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation Sowa, M.B., Goetz, W., Baulch, J., and Morgan, W.F. Genetic Factors Affecting Susceptibility to Low-Dose Radiation

68

Low Dose Radiation Research Program: Melvyn Folkard  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Melvyn Folkard Melvyn Folkard Gray Cancer Institute About this Project Currently Funded Projects A Variable Energy Soft X-ray Microprobe to Investigate Mechanisms of the Radiation-Induced Bystander Effect Technical Abstracts 2005 Workshop: A Variable-Energy Soft X-Ray Microprobe to Investiage Mechanisms of the Radiation-Induced Bystander Effect Folkard, M., Vojnovic, B., Schettiono, G., Atkinson, K., Prise, K.M., Michael, B.D. 2003 Workshop: A Variable-Energy Soft X-Ray Microprobe to Investigate Mechanisms of the Radiation -Induced Bystander Effect. Folkard, M., Vojnovic, B., Schettino, G., Atkinson, K., Prise, K.M., Michael, B.D. 2002 Workshop: A Variable-Energy Soft X-ray Microprobe to Investigate Mechanisms of the Radiation-Induced Bystander Effect. Folkard, M., Vojnovic, B., Schettino,

69

Japan Program: Radiation Effects Research Foundation | Department...  

Broader source: Energy.gov (indexed) [DOE]

The Life Span Study is the major RERF epidemiologic study that generates data on cancer incidence, cancer mortality, and non-cancer effects in relation to radiation dose. The...

70

Nevada Test Site Radiation Protection Program - Revision 1  

SciTech Connect (OSTI)

Title 10 Code of Federal Regulations (CFR) Part 835, 'Occupational Radiation Protection,' establishes radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of U.S. Department of Energy (DOE) activities. 10 CFR 835.101(a) mandates that DOE activities be conducted in compliance with a documented Radiation Protection Program (RPP) as approved by DOE. This document promulgates the RPP for the Nevada Test Site (NTS), related (on-site or off-site) U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office (NNSA/NSO) operations, and environmental restoration off-site projects. This NTS RPP promulgates the radiation protection standards, limits, and program requirements for occupational exposure to ionizing radiation resulting from NNSA/NSO activities at the NTS and other operational areas as stated in 10 CFR 835.1(a). NNSA/NSO activities (including design, construction, operation, and decommissioning) within the scope of this RPP may result in occupational exposures to radiation or radioactive material. Therefore, a system of control is implemented through specific references to the site-specific NV/YMP RCM. This system of control is intended to ensure that the following criteria are met: (1) occupational exposures are maintained as low as reasonably achievable (ALARA), (2) DOE's limiting values are not exceeded, (3) employees are aware of and are prepared to cope with emergency conditions, and (4) employees are not inadvertently exposed to radiation or radioactive material.

Radiological Control Managers' Council

2008-06-01T23:59:59.000Z

71

Low Dose Radiation Research Program: Research Highlights - Ionizing  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Affects Cancer Frequency and Characteristics by Acting Affects Cancer Frequency and Characteristics by Acting on the Microenvironment Background: For more than a quarter century the scientific rationale for extrapolating radiation health effects has been underpinned by biophysical target theory. Fundamental to target theory is that the effect (e.g., DNA damage, mutation, cancer) is proportional to dose based on interaction of energy with biological targets, specifically DNA. However, the biology following ionizing radiation is more than just DNA damage, repair, or misrepair. Cellular responses to ionizing radiation can affect phenotype, cell interactions, lineage commitment, differentiation and genomic stability, all of which have been widely documented in cultured cells and many observed in vivo. This class of non-targeted effects induced

72

Low Dose Radiation Research Program: 2003 Molecular Characterization of the  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Characterization of the Roles of SOD Genes in Mammalian Characterization of the Roles of SOD Genes in Mammalian Cellular Response to Low Dose Radiation Authors: Chuan-Yuan Li,1 Eric Chuang2 Institutions: 1Dept of Radiation Oncology, Duke University Medical Center, Durham, NC, 2Advanced Technology Center, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland The potential risks of exposure to low dose radiation are of major concerns to the DOE/OBER Low Dose Radiation Research Program. It has been long recognized that much of the radiation-induced genetic damage to cells are caused by secondary oxidative species. Therefore, internal cellular defense systems against oxidative stress play significant roles in countering genetic damage induced by ionizing radiation. The role of the detoxifying

73

Low Dose Radiation Research Program: Molecular Characterization of the  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Molecular Characterization of the Roles of SOD Genes in Mammalian Molecular Characterization of the Roles of SOD Genes in Mammalian Cellular Response to Low Dose Radiation Authors: Chuan-Yuan Li, Zhanjun Guo, Zhonghui Yang, and Eric Chuang Institutions: Dept of Radiation Oncology, Duke University Medical Center, Durham, NC Advanced Technology Center, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Background The potential risks of exposure to low dose radiation are of major concerns to the DOE/OBER Low Dose Radiation Research Program. It has been long recognized that much of the radiation-induced genetic damage to cells are caused by secondary oxidative species. Therefore internal cellular defense systems against oxidative stress play significant roles in countering genetic damage induced by ionizing radiation. The role of the detoxifying

74

Low Dose Radiation Research Program: Optimizing the Scientific, Regulatory,  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Optimizing the Scientific, Regulatory, and Societal Impact of the DOE Low Optimizing the Scientific, Regulatory, and Societal Impact of the DOE Low Dose Radiation Research Program Antone L. Brooks Why This Project? For maximum benefit, state-of-the-art research and new data from the Low Dose Radiation Research Program must be available to other scientists, regulatory agencies, and the public. This project stays abreast of scientific advances in the field, gathers, integrates, and summarizes the research within the program, and disseminates this information to appropriate scientific, regulatory, and public venues. Project Goals Provides a focal point for distribution of information generated in the program, to scientific committees, other governmental and regulatory agencies, and to the public Provides scientific support for the Low Dose Program website

75

Experimental methodology for non-thermal effects of electromagnetic radiation on biologics  

E-Print Network [OSTI]

Appropriate equipment is needed for research on the effects of radio-frequency radiation from radio-frequency identification (RF-ID) systems on biological materials. In the present study, a complete test system comprising ...

Cox, Felicia C. A. I

2006-01-01T23:59:59.000Z

76

Low Dose Radiation Research Program: Chaun-Yuan Li  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Chaun-Yuan Li Chaun-Yuan Li Radiation Biology Research, Duke University Medical Center Funded Projects Molecular Characterization of the Role of SOD Genes in Mammalian Cellular Response to Low Dose Ionizing, abstract, description. Technical Abstracts 2006 Workshop: The Roles of Superoxide Dismutage (SOD) in Low Dose Radiation Induced Adaptive Response Yang, Z., Chuang, E., Batinic-Haberle, I., and Li, C.-Y. 2005 Workshop: Molecular Characterization of the Roles of SOD Genes in Mammalian Cellular Response to Low Dose Radiation Li, C.-Y., Guo, Z., Yang, Z., and Chuang, E. 2003 Workshop: Molecular Characterization of the Roles of SOD Genes in Mammalian Cellular Response to Low Dose Radiation Li, C.-Y. and Chuang, E. Publications Li, F., Sonveaux, P., Rabbani, Z.N., Liu, S., Yan, B., Huang, Q.,

77

Low Dose Radiation Research Program: Genetic Factors Affecting  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Genetic Factors Affecting Susceptibility to Low-Doses of Ionizing Genetic Factors Affecting Susceptibility to Low-Doses of Ionizing Radiation. Authors: William F. Morgan, Pat Concannon & John H.J. Petrini The goal of this program is to test the hypothesis that mice heterozygous for the NBS1 gene are genetically susceptible to low doses of ionizing radiation. Patients with Nijmegen Breakage Syndrome (NBS) are radiation sensitive, because of defects in cellular responses to radiation induced genetic damage. It is unclear whether humans heterozygous for the mutations associated with NBS are radiation sensitive and results from cell culture experiments give conflicting results. In collaboration with John Petrini at the Memorial Sloan Kettering Cancer Center in New York City we developed a mouse model of this disorder and are directly testing the hypothesis

78

The Research Program | Stanford Synchrotron Radiation Lightsource  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

The Research Program The Research Program What is the chemical and physical form of uranium in reduced aquifers? Uranium behavior in the Rifle, CO, aquifer. In order to directly interrogate the chemical and physical form of reduced uranium (U(IV)) in bioremediated sediments within the contaminated aquifer at the Rifle site, a novel technique was developed based on reactors installed in wells (center right). U(IV) was found to be bound to biomass (structural model shown in upper left-hand) within thin (microns) sulfide-rich coatings on mineral grains (bottom left). Uranium in its oxidized (U(VI)) form, is one of the most common, abundant, and problematic subsurface contaminants at legacy nuclear sites. In contrast, the tetravalent form of uranium (U(IV) ) is relatively insoluble

79

Low Dose Radiation Research Program: Glossary  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Glossary Glossary A B C D E F G H I J K L M N O P Q R S T U V W X Y Z We welcome updates to the glossary. Please send them to Low Dose. A α=β Ratio: A measure of the curvature of the cell survival curve and a measure of the sensitivity of a tissue or tumor to dose fractionation. The dose at which the linear and quadratic components of cell killing are equal. Abscopal Effect: The radiation response in tissue at a distance from the irradiated site invoked by local irradiation. Absorbed Dose Rate: Absorbed dose divided by the time it takes to deliver that dose. High dose rates are usually more damaging to humans and animals than low-dose rates. This is because repair of damage is more efficient when the dose rate is low. Absorbed Dose: The amount of energy deposited in any substance by ionizing

80

United States Department of Energy Low Dose Radiation Research Program  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

History of the History of the United States Department of Energy (DOE) Low Dose Radiation Research Program: 1998-2008 Dr. Antone L. Brooks tbrooks@tricity.wsu.edu September 2012 Review Draft i Contents Preface............................................................................................................................................. v Summary ........................................................................................................................................ vi Acronyms and Initialisms ............................................................................................................. vii Chapter 1 Introduction ................................................................................................................... 1

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

PROGRESS REPORT ON THE BIOLOGICAL MONITORING PROGRAM FOR THE  

Office of Legacy Management (LM)

PROGRESS PROGRESS REPORT ON THE BIOLOGICAL MONITORING PROGRAM FOR THE MONTICELLO, UTAH, MILL SITE: AUGUST 1996 SAMPLING PERIOD J. G. Smith M. J. Peterson M. G. Ryon G. R. Southworth Date: March 3, 1997 Prepared for G. A. Pierce Health and Safety Research Division Environmental Technology Section OakRidge National Laboratory Grand Junction, Colorado Prepared by Environmental Sciences Division Oak Ridge National Laboratory Oak Ridge, Tennessee 37831 Managed by LOCKHEED MARTIN ENERGY RESEARCH CORP. for the U.S. DEPARTMENT OF ENERGY under contract DE-AC05-960R22464 2 I. INTRODUCTION From 1942 through 1946, the Vanadium Corporation of America operated a vanadium and uranium mill in Monticello, Utah (Rust Geotech 1995a). In 1948, the U. S. Atomic Energy Commission (AEC) purchased the mill site and milled uranium from 1949 until the mill was permanently closed in January 1960. During operation

82

Biological Basis for Radiation Adaptive Responses that Protect Against  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Basis for Radiation Adaptive Responses that Protect Against Basis for Radiation Adaptive Responses that Protect Against Bronchial Epithelial Cell Transformation Wenshu Chen Lovelace Respiratory Research Institute Abstract The major hypothesis in this project is that low-dose, low linear-energy-transfer (LET) radiation stimulates an adaptive response that protects cells from neoplastic transformation involving modulation of paracrine factors (e.g., cytokines), cell survival/death signaling pathways, and reprogramming of the epigenome. To test this hypothesis, a validated, sensitive in vitro transformation model and a media transfer method were used to study the mechanisms of low-LET gamma radiation activated natural protection (ANP) against chemical carcinogen-induced bronchial cell transformation. Immortalized human bronchial epithelial cell

83

Computer program for comparison of nutrient media for biological cultures grown in vitro  

Science Journals Connector (OSTI)

A computer program in BASIC computer language for use in storing and comparing the components of various biological culture media is described. The program contains 11 operations that deal with manipulation of...

Stanley L. Nickel; Mary C. Grant

1982-01-01T23:59:59.000Z

84

Modular Systems Biology applied to TGFbeta and DNA Damage Response Signaling following Low Dose Radiation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Modular Systems Biology applied to TGFbeta and DNA Damage Response Signaling following Modular Systems Biology applied to TGFbeta and DNA Damage Response Signaling following Low Dose Radiation Francis A. Cucinotta 1 , Yongfeng Li 2 , Minli Wang 2 , Claudio Carra 2 , Janice Pluth 3 , and Peter O'Neill 4 1 NASA Johnson Space Center, Houston, TX 2 U.S.R.A. Division of Life Sciences, Houston TX 3 Lawrence Berkeley National Laboratory, Berkeley CA 4 Oxford University, Oxford UK Abstract: Modular systems biology (MSB) describes the complexity of biological systems using well defined modules that represent distinct biological response pathways or sub-systems within pathways. We review mathematical concepts from control theory that can be used to identify and construct well defined modules for describing complex biological processes. The DNA damage response and TGFbeta/Smad signaling are two important response pathways following

85

Low Dose Radiation Research Program: Optimizing the Scientific, Regulatory  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Optimizing the Scientific, Regulatory and Societal Impact of the DOE Optimizing the Scientific, Regulatory and Societal Impact of the DOE Low Dose Research Program Authors: Antone L. Brooks Institution: Washington State University Tri-Cities Richland, Washington The purpose of this project is to provide a focal point for communication of the research results from the DOE Low Dose Radiation Research Program. The major communication tool provided by this project is a Website at Washington State University. The website is being maintained to provide communication between the scientific advances generated by the research program and scientists both in and outside the program, policy makers, regulators and the public. The website also contains a number of presentations and illustrations that are written so that they will be easy

86

Low Dose Radiation Research Program: DOE / NASA Joint Funded Projects  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

DOE/NASA Joint Funded Projects DOE/NASA Joint Funded Projects NASA Source Photo Space explorers are subject to exposure to low dose ionizing radiation. Research that helps determine health risks from this exposure is funded by NASA and DOE. Source: NASA DOE's Low Dose Program and the National Aeronautics and Space Administration (NASA) jointly fund new research to develop a better scientific basis for understanding risks to humans from exposures to low doses or low fluences of ionizing radiation. Research must focus on elucidating molecular mechanisms and pathways involved in normal radiobiological responses to low dose exposure, and must have the potential to ultimately increase understanding of health outcomes from radiation exposures that are at or near current workplace exposure

87

The Ecology and Organismal/Evolutionary Biology Program at Old Dominion University  

E-Print Network [OSTI]

1 The Ecology and Organismal/Evolutionary Biology Program at Old Dominion University Prepared students for careers in ecology and organismal/evolutionary biology and seek new knowledge through research. Vision: To be one of the premier programs in the country in ecological and organismal

88

Low Dose Radiation Research Program: Computational Modeling of Biochemical  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Computational Modeling of Biochemical Pathways Linking Ionizing Computational Modeling of Biochemical Pathways Linking Ionizing Radiation to Cell Cycle Arrest, Apoptosis, and Tumor Incidence Authors: Yuchao Maggie Zhao and Rory Conolly Institutions: Center for Computational Systems Biology CIIT Centers for Health Research Long-Range Goal: To develop an integrated, computational framework for the prediction of low-dose-response to ionizing radiation (IR) in people. Methodology: To provide a flexible framework to evaluate mechanisms of cellular adaptive responses after exposure to IR, three progressively more complicated descriptions of biochemical pathways linking DNA damage with cell-cycle checkpoint control and apoptosis were developed. These descriptions focus on p53-dependent checkpoint arrest and apoptosis, p73-dependent apoptosis, and Chk2-dependent checkpoint arrest,

89

Atmospheric radiation measurement: A program for improving radiative forcing and feedback in general circulation models  

SciTech Connect (OSTI)

The Atmospheric Radiation Measurement (ARM) Program is a key element of the Department of Energy`s (DOE`s) global change research strategy. ARM represents a long-term commitment to conduct comprehensive studies of the spectral atmospheric radiative energy balance profile for a wide range of cloud conditions and surface types, and to develop the knowledge necessary to improve parameterizations of radiative processes under various cloud regimes for use in general circulation models (GCMs) and related models. The importance of the ARM program is a apparent from the results of model assessments of the impact on global climate change. Recent studies suggest that radiatively active trace gas emissions caused by human activity can lead to a global warming of 1.5 to 4.5 degrees Celsius and to important changes in water availability during the next century (Cess, et al. 1989). These broad-scale changes can be even more significant at regional levels, where large shifts in temperature and precipitation patterns are shown to occur. However, these analyses also indicate that considerable uncertainty exists in these estimates, with the manner in which cloud radiative processes are parameterized among the most significant uncertainty. Thus, although the findings have significant policy implications in assessment of global and regional climate change, their uncertainties greatly influence the policy debate. ARM`s highly focused observational and analytical research is intended to accelerate improvements and reduce key uncertainties associated with the way in which GCMs treat cloud cover and cloud characteristics and the resulting radiative forcing. This paper summarizes the scientific context for ARM, ARM`s experimental approach, and recent activities within the ARM program.

Patrinos, A.A. [USDOE, Washington, DC (United States); Renne, D.S.; Stokes, G.M. [Pacific Northwest Lab., Richland, WA (United States); Ellingson, R.G. [Maryland Univ., College Park, MD (United States)

1991-01-01T23:59:59.000Z

90

Atmospheric radiation measurement: A program for improving radiative forcing and feedback in general circulation models  

SciTech Connect (OSTI)

The Atmospheric Radiation Measurement (ARM) Program is a key element of the Department of Energy's (DOE's) global change research strategy. ARM represents a long-term commitment to conduct comprehensive studies of the spectral atmospheric radiative energy balance profile for a wide range of cloud conditions and surface types, and to develop the knowledge necessary to improve parameterizations of radiative processes under various cloud regimes for use in general circulation models (GCMs) and related models. The importance of the ARM program is a apparent from the results of model assessments of the impact on global climate change. Recent studies suggest that radiatively active trace gas emissions caused by human activity can lead to a global warming of 1.5 to 4.5 degrees Celsius and to important changes in water availability during the next century (Cess, et al. 1989). These broad-scale changes can be even more significant at regional levels, where large shifts in temperature and precipitation patterns are shown to occur. However, these analyses also indicate that considerable uncertainty exists in these estimates, with the manner in which cloud radiative processes are parameterized among the most significant uncertainty. Thus, although the findings have significant policy implications in assessment of global and regional climate change, their uncertainties greatly influence the policy debate. ARM's highly focused observational and analytical research is intended to accelerate improvements and reduce key uncertainties associated with the way in which GCMs treat cloud cover and cloud characteristics and the resulting radiative forcing. This paper summarizes the scientific context for ARM, ARM's experimental approach, and recent activities within the ARM program.

Patrinos, A.A. (USDOE, Washington, DC (United States)); Renne, D.S.; Stokes, G.M. (Pacific Northwest Lab., Richland, WA (United States)); Ellingson, R.G. (Maryland Univ., College Park, MD (United States))

1991-01-01T23:59:59.000Z

91

Science Plan for the Atmospheric Radiation Measurement Program (ARM)  

SciTech Connect (OSTI)

The purpose of this Atmospheric Radiation Measurement (ARM) Science Plan is to articulate the scientific issues driving the ARM Program, and to relate them to DOE`s programmatic objectives for ARM, based on the experience and scientific progress gained over the past five years. ARM programmatic objectives are to: (1) Relate observed radiative fluxes and radiances in the atmosphere, spectrally resolved and as a function of position and time, to the temperature and composition of the atmosphere, specifically including water vapor and clouds, and to surface properties, and sample sufficient variety of situations so as to span a wide range of climatologically relevant possibilities; (2) develop and test parameterizations that can be used to accurately predict the radiative properties and to model the radiative interactions involving water vapor and clouds within the atmosphere, with the objective of incorporating these parameterizations into general circulation models. The primary observational methods remote sending and other observations at the surface, particularly remote sensing of clouds, water vapor and aerosols.

NONE

1996-02-01T23:59:59.000Z

92

Atmospheric Radiation Measurement Program Climate Research Facility Operations  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

8 8 Atmospheric Radiation Measurement Program Climate Research Facility Operations Quarterly Report January 1-March 31, 2011 DISCLAIMER This report was prepared as an account of work sponsored by the U.S. Government. Neither the United States nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or

93

Low Dose Radiation Research Program: Use of Computational Modeling to  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Use of Computational Modeling to Evaluate Hypotheses about the Use of Computational Modeling to Evaluate Hypotheses about the Molecular and Cellular Mechanisms of Bystander Effects Authors: Yuchao “Maggie” Zhao and Rory Conolly Institutions: CIIT Centers for Health Research, 6 Davis Drive, Research Triangle Park, North Carolina A detailed understanding of the biological mechanisms of radiation-induced damage at the molecular and cellular levels is needed for accurate assessment of the shape of the dose-response curve for radiationinduced health effects in the intact organism. Computational models can contribute to the improved understanding of mechanisms through integration of data and quantitative evaluation of hypotheses. We propose to develop a novel computational model of bystander effects elicited by oxidative stress and a

94

Low Dose Radiation Research Program: Quantitative Analysis of Connexin  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Quantitative Analysis of Connexin Expression in Cultured Colonies Quantitative Analysis of Connexin Expression in Cultured Colonies Authors: B. Parvin, Q. Yang, R. L. Henshall-Powell and M.H. Barcellos Hoff We are studying the effects of ionizing radiation on the signaling between human mammary epithelial cells and the extracellular microenvironment. To do so we use an assay based on the ability of the cells to organize into three-dimensional acini when embedded into an extracellular matrix. Although tumorigenic and non-tumorigenic mammary epithelial cells are nearly indistinguishable when cultured as monolayers, their biological character readily diverge when tissue-specific morphogenesis is analyzed. Non-malignant human mammary epithelial cells (HMEC) cultured within a reconstituted basement membrane organize into acinar-like structures with

95

Bibliographical database of radiation biological dosimetry and risk assessment: Part 1, through June 1988  

SciTech Connect (OSTI)

This database was constructed to support research in radiation biological dosimetry and risk assessment. Relevant publications were identified through detailed searches of national and international electronic databases and through our personal knowledge of the subject. Publications were numbered and key worded, and referenced in an electronic data-retrieval system that permits quick access through computerized searches on publication number, authors, key words, title, year, and journal name. Photocopies of all publications contained in the database are maintained in a file that is numerically arranged by citation number. This report of the database is provided as a useful reference and overview. It should be emphasized that the database will grow as new citations are added to it. With that in mind, we arranged this report in order of ascending citation number so that follow-up reports will simply extend this document. The database cite 1212 publications. Publications are from 119 different scientific journals, 27 of these journals are cited at least 5 times. It also contains reference to 42 books and published symposia, and 129 reports. Information relevant to radiation biological dosimetry and risk assessment is widely distributed among the scientific literature, although a few journals clearly dominate. The four journals publishing the largest number of relevant papers are Health Physics, Mutation Research, Radiation Research, and International Journal of Radiation Biology. Publications in Health Physics make up almost 10% of the current database.

Straume, T.; Ricker, Y.; Thut, M.

1988-08-29T23:59:59.000Z

96

Comparative Biomedical Sciences is one of five graduate fields associated with the Biological & Biomedical Sciences (BBS) Graduate Program. As an umbrella program, the BBS fosters an atmosphere  

E-Print Network [OSTI]

Background Comparative Biomedical Sciences is one of five graduate fields associated with the Biological & Biomedical Sciences (BBS) Graduate Program. As an umbrella program, the BBS fosters fields are members of the BBS Graduate Program: Comparative Biomedical Sciences Immunology & Infectious

Walter, M.Todd

97

Burnout in United States Academic Chairs of Radiation Oncology Programs  

SciTech Connect (OSTI)

Purpose: The aims of this study were to determine the self-reported prevalence of burnout in chairs of academic radiation oncology departments, to identify factors contributing to burnout, and to compare the prevalence of burnout with that seen in other academic chair groups. Methods and Materials: An anonymous online survey was administered to the membership of the Society of Chairs of Academic Radiation Oncology Programs (SCAROP). Burnout was measured with the Maslach Burnout Inventory-Human Services Survey (MBI-HSS). Results: Questionnaires were returned from 66 of 87 chairs (76% response rate). Seventy-nine percent of respondents reported satisfaction with their current positions. Common major stressors were budget deficits and human resource issues. One-quarter of chairs reported that it was at least moderately likely that they would step down in the next 1 to 2 years; these individuals demonstrated significantly higher emotional exhaustion. Twenty-five percent of respondents met the MBI-HSS criteria for low burnout, 75% for moderate burnout, and none for high burnout. Group MBI-HSS subscale scores demonstrated a pattern of moderate emotional exhaustion, low depersonalization, and moderate personal accomplishment, comparing favorably with other specialties. Conclusions: This is the first study of burnout in radiation oncology chairs with a high response rate and using a validated psychometric tool. Radiation oncology chairs share similar major stressors to other chair groups, but they demonstrate relatively high job satisfaction and lower burnout. Emotional exhaustion may contribute to the anticipated turnover in coming years. Further efforts addressing individual and institutional factors associated with burnout may improve the relationship with work of chairs and other department members.

Kusano, Aaron S. [Department of Radiation Oncology, University of Washington School of Medicine, Seattle, Washington (United States); Thomas, Charles R., E-mail: thomasch@ohsu.edu [Department of Radiation Medicine, Knight Cancer Institute/Oregon Health and Science University, Portland, Oregon (United States); Bonner, James A. [Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama (United States); DeWeese, Theodore L. [Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland (United States); Formenti, Silvia C. [Department of Radiation Oncology, New York University, New York, New York (United States); Hahn, Stephen M. [Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania (United States); Lawrence, Theodore S. [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States); Mittal, Bharat B. [Department of Radiation Oncology, Northwestern University, Chicago, Ilinois (United States)

2014-02-01T23:59:59.000Z

98

Contributions of the Atmospheric Radiation Measurement (ARM) Program and the ARM Climate Research Facility to the U.S. Climate Change Science Program  

SciTech Connect (OSTI)

The Earths surface temperature is determined by the balance between incoming solar radiation and thermal (or infrared) radiation emitted by the Earth back to space. Changes in atmospheric composition, including greenhouse gases, clouds, and aerosols can alter this balance and produce significant climate change. Global climate models (GCMs) are the primary tool for quantifying future climate change; however, there remain significant uncertainties in the GCM treatment of clouds, aerosol, and their effects on the Earths energy balance. The 2007 assessment (AR4) by the Intergovernmental Panel on Climate Change (IPCC) reports a substantial range among GCMs in climate sensitivity to greenhouse gas emissions. The largest contributor to this range lies in how different models handle changes in the way clouds absorb or reflect radiative energy in a changing climate (Solomon et al. 2007). In 1989, the U.S. Department of Energy (DOE) Office of Science created the Atmospheric Radiation Measurement (ARM) Program within the Office of Biological and Environmental Research (BER) to address scientific uncertainties related to global climate change, with a specific focus on the crucial role of clouds and their influence on the transfer of radiation in the atmosphere. To address this problem, BER has adopted a unique two-pronged approach: * The ARM Climate Research Facility (ACRF), a scientific user facility for obtaining long-term measurements of radiative fluxes, cloud and aerosol properties, and related atmospheric characteristics in diverse climate regimes. * The ARM Science Program, focused on the analysis of ACRF data to address climate science issues associated with clouds, aerosols, and radiation, and to improve GCMs. This report describes accomplishments of the BER ARM Program toward addressing the primary uncertainties related to climate change prediction as identified by the IPCC.

SA Edgerton; LR Roeder

2008-09-30T23:59:59.000Z

99

Genetic Programming: Biologically Inspired Computation that Exhibits Creativity in Solving Non-Trivial Problems  

E-Print Network [OSTI]

Genetic Programming: Biologically Inspired Computation that Exhibits Creativity in Solving Non-produced results. We present several results that are competitive with the products of human creativity created? · Can automatically created programs be competitive with the products of human creativity

Fernandez, Thomas

100

Low Dose Radiation Research Program: Quantification of Repair of  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Quantification of Repair of Low-Dose-Induced DNA Double-Strand Quantification of Repair of Low-Dose-Induced DNA Double-Strand Breaks in Diploid Human Cells Authors: David Schild,1 and Larry H. Thompson,2 Institutions: 1Life Sciences Division, Lawrence Berkeley National Laboratory; and 2BBR Program, Lawrence Livermore National Laboratory Double-strand breaks (DSBs) are the biochemical lesions of primary concern in radiation related health effects. Compelling evidence from rodent and chicken model systems indicates that homologous recombinational repair (HRR) plays an essential role for cell viability in the repair of spontaneous DSBs arising during DNA replication and an important role in the repair of IR-induced DSBs. IR-induced DSBs are also repaired by error-prone nonhomologous end joining (NHEJ). Using hTERT-immortalized

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Atmospheric Radiation Measurement Program facilities newsletter, January 2000  

SciTech Connect (OSTI)

The subject of this newsletter is the ARM unmanned aerospace vehicle program. The ARM Program's focus is on climate research, specifically research related to solar radiation and its interaction with clouds. The SGP CART site contains highly sophisticated surface instrumentation, but even these instruments cannot gather some crucial climate data from high in the atmosphere. The Department of Energy and the Department of Defense joined together to use a high-tech, high-altitude, long-endurance class of unmanned aircraft known as the unmanned aerospace vehicle (UAV). A UAV is a small, lightweight airplane that is controlled remotely from the ground. A pilot sits in a ground-based cockpit and flies the aircraft as if he were actually on board. The UAV can also fly completely on its own through the use of preprogrammed computer flight routines. The ARM UAV is fitted with payload instruments developed to make highly accurate measurements of atmospheric flux, radiance, and clouds. Using a UAV is beneficial to climate research in many ways. The UAV puts the instrumentation within the environment being studied and gives scientists direct measurements, in contrast to indirect measurements from satellites orbiting high above Earth. The data collected by UAVs can be used to verify and calibrate measurements and calculated values from satellites, therefore making satellite data more useful and valuable to researchers.

Sisterson, D.L.

2000-02-16T23:59:59.000Z

102

Berkeley Lab Scientific Programs: Biological Sciences for Energy Research  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biological Sciences for Energy Research Biological Sciences for Energy Research Biosci image Arabidopsis plants in the growth room at the Joint BioEnergy Institute (JBEI) Biomass encompasses all plant or vegetative materials and represents a vast repository of solar energy that was captured and stored in plant sugars via photosynthesis. Extracting and fermenting plant sugars into advanced biofuels that can replace gasoline on a gallon-for-gallon basis has the potential to far exceed today's entire global production of oil. Berkeley Lab researchers are working towards this goal via three major efforts - the Joint BioEnergy Institute, the Joint Genome Institute, and the Energy Biosciences Institute. The Joint BioEnergy Institute (JBEI) JBEI is one of the three U.S. Department of Energy (DOE) Bioenergy Research

103

The international biological program and the science of ecology.  

Science Journals Connector (OSTI)

...analysis have attracted personnel proficient in computer...is also evident that selection factors involve more...its programs for the training of foreign scientists...international exchange of personnel. We are ex- ploring...components that must be operating, since a synthesis...

F E Smith

1968-01-01T23:59:59.000Z

104

Biology and Management of Fungal Pathogens of Vegetables Program Leader  

E-Print Network [OSTI]

, and determining efficacy of disease control products #12;Re cauliflower rubber bands.msg Alternaria leaf spot on cabbage Program Justification: Fungal diseases are often a major limiting factor in vegetable production seeks to find cost effective disease control measures that result in production of high quality produce

Lazzaro, Brian

105

Low Dose Radiation Research Program: Genetic Factors Affecting  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Affecting Susceptibility to Low-Dose Radiation Affecting Susceptibility to Low-Dose Radiation William F. Morgan Pacific Northwest National Laboratory Why This Project The short-term effects of high doses of ionizing radiation on cellular responses are relatively well understood. Less clear are the long-term consequences of exposure to low dose/low dose-rate radiation and the effects of radiation exposure on the progeny of surviving cells. If a cell survives radiation, it is generally thought to have repaired all the radiation-induced insults and be capable of a "normal healthy life". At a certain frequency, however, we have found that some cells surviving radiation grow normally, but will rearrange their genetic material during time in culture. We call this radiation-induced genomic instability. Many

106

Low Dose Radiation Research Program: Wide Expression of LLIR and the  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Wide Expression of LLIR and the Biological Consequences Wide Expression of LLIR and the Biological Consequences David J. Chen Lawrence Berkeley National Laboratory Why This Project It is known that changes in gene expression alter biological effects. It is necessary to identify the specific genes that demonstrate altered expression after exposure to low doses of ionizing radiation and to determine pathways involved in DNA damage recognition, signaling, and repair that are associated with radiation-induced adaptive and bystander effects. Project Goals Identification of genes whose transcription is regulated in response to low levels of ionizing radiation Identification of the genes and communication pathways that control these responses to low dose radiation Identification of the cellular and molecular targets that influence

107

Russian Health Studies Program - Relationship to Other Radiation...  

Office of Environmental Management (EM)

the Mayak workers had long-term exposures (10 to 30 years) to plutonium, gamma, and neutron radiation. This combination of radiation types over a working lifetime is more...

108

AICD -- Advanced Industrial Concepts Division Biological and Chemical Technologies Research Program. 1993 Annual summary report  

SciTech Connect (OSTI)

The annual summary report presents the fiscal year (FY) 1993 research activities and accomplishments for the United States Department of Energy (DOE) Biological and Chemical Technologies Research (BCTR) Program of the Advanced Industrial Concepts Division (AICD). This AICD program resides within the Office of Industrial Technologies (OIT) of the Office of Energy Efficiency and Renewable Energy (EE). The annual summary report for 1993 (ASR 93) contains the following: A program description (including BCTR program mission statement, historical background, relevance, goals and objectives), program structure and organization, selected technical and programmatic highlights for 1993, detailed descriptions of individual projects, a listing of program output, including a bibliography of published work, patents, and awards arising from work supported by BCTR.

Petersen, G.; Bair, K.; Ross, J. [eds.

1994-03-01T23:59:59.000Z

109

Photosynthesis & Respiration 2009 1 Minority Science Programs School of Biological Sciences University of California, Irvine  

E-Print Network [OSTI]

Photosynthesis & Respiration 2009 1 Minority Science Programs ­ School of Biological Sciences" hetero = "another" 2. During photosynthesis, plants and phytoplankton use energy from the sun to combine: An anacharis plant in water produces oxygen when it photosynthesizes. 3. Photosynthesis takes place within

Rose, Michael R.

110

Low Dose Radiation Research Program: Bruce E. Lehnert  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

E. Lehnert E. Lehnert Los Alamos National Laboratory Past Project Low Dose Ionizing Radiation-Induced Effects in Irradiated and Unirradiated Cells: Pathways Analysis in Support of Risk Assessment. Technical Abstracts 2002 Workshop: Low Dose Ionizing Radiation-Induced Effects in Irradiated and Unirradiated cells: Pathways Analysis in Support of Risk Assessment. Lehnert, B.E., Cary, R., Gadbois, D. and Gupta G. 2001 Workshop: Low Dose, Low Dose Rate Effects of Ionizing Radiation in Irradiated and Unirradiated Cells. Lehnert, B.E. 1999 Workshop: Low Dose, Low Dose Rate Effects of Ionizing Radiation in Irradiated and Unirradiated Cells. Lehnert, B.E. Publications Lehnert, B.E., Radiation bystander effects. U.S.Department of Energy Research News (March 6 issue) Goldberg, Z. and Lehnert, B.E. (2002). Radiation-induced effects in

111

Low Dose Radiation Research Program: Identification of Mouse Genetic  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mouse Genetic Susceptibility to Radiation Carcinogenesis Mouse Genetic Susceptibility to Radiation Carcinogenesis Allan Balmain University of California, San Francisco San Francisco, CA. (Jointly funded by NASA and DOE) Why this Project? To identify pathways that control genetic susceptibility to radiation-induced DNA damage and tumor development using novel developments in genomics together with mouse genetics. Project Goals To identify genetic loci that trigger rapid tumor development of mice after radiation. To characterize new genes at these loci that act as tumor suppressor genes or oncogenes. Experimental Approach New candidate-radiation susceptibility genes will be identified using a unique haplotyping approach. Using DNA from radiation-induced lymphoma, changes in the gene copy number can be detected using BAC microarrays. The

112

Formal Safety Analysis of the Control Program for a Radiation Therapy Machine  

Science Journals Connector (OSTI)

A central problem in software development is to assure that a complex program actually meets its requirements. This problem is most urgent in applications such as the control of radiation therapy machines, whe...

Jonathan Jacky

2000-01-01T23:59:59.000Z

113

Research Reactors and Radiation Facilities for Joint Use Program  

E-Print Network [OSTI]

Observatory, a facility of the Graduate School of Science of Kyoto University, was constructed in 1968's current main research target is to unveil the origin of the solar magnetic activities that govern science and technology, material science, radiation life science, and radiation medical science

Takada, Shoji

114

Prognostic Cell Biological Markers in Cervical Cancer Patients Primarily Treated With (Chemo)radiation: A Systematic Review  

SciTech Connect (OSTI)

The aim of this study was to systematically review the prognostic and predictive significance of cell biological markers in cervical cancer patients primarily treated with (chemo)radiation. A PubMed, Embase, and Cochrane literature search was performed. Studies describing a relation between a cell biological marker and survival in {>=}50 cervical cancer patients primarily treated with (chemo)radiation were selected. Study quality was assessed, and studies with a quality score of 4 or lower were excluded. Cell biological markers were clustered on biological function, and the prognostic and predictive significance of these markers was described. In total, 42 studies concerning 82 cell biological markers were included in this systematic review. In addition to cyclooxygenase-2 (COX-2) and serum squamous cell carcinoma antigen (SCC-ag) levels, markers associated with poor prognosis were involved in epidermal growth factor receptor (EGFR) signaling (EGFR and C-erbB-2) and in angiogenesis and hypoxia (carbonic anhydrase 9 and hypoxia-inducible factor-1{alpha}). Epidermal growth factor receptor and C-erbB-2 were also associated with poor response to (chemo)radiation. In conclusion, EGFR signaling is associated with poor prognosis and response to therapy in cervical cancer patients primarily treated with (chemo)radiation, whereas markers involved in angiogenesis and hypoxia, COX-2, and serum SCC-ag levels are associated with a poor prognosis. Therefore, targeting these pathways in combination with chemoradiation may improve survival in advanced-stage cervical cancer patients.

Noordhuis, Maartje G.; Eijsink, Jasper J.H.; Roossink, Frank; Graeff, Pauline de [Department of Gynecologic Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Pras, Elisabeth [Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Schuuring, Ed [Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Wisman, G. Bea A. [Department of Gynecologic Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Bock, Geertruida H. de [Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands); Zee, Ate G.J. van der, E-mail: a.g.j.van.der.zee@og.umcg.n [Department of Gynecologic Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)

2011-02-01T23:59:59.000Z

115

Phoenix Leader Education Program (Hiroshima Initiative) for Renaissance from Radiation Disaster  

E-Print Network [OSTI]

Phoenix Leader Education Program (Hiroshima Initiative) for Renaissance from Radiation Disaster The 3rd International Symposium "Nature, Human being, and Radiation"was held at International Conference Center Hiroshima on February 15-16, 2014. With guest speakers from Japan and abroad, participation

Ishii, Hitoshi

116

Low Dose Radiation Research Program: Gregory A. Kimmel  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Gregory A. Kimmel Gregory A. Kimmel Pacific Northwest National Laboratory Past Project A Novel Spatially Resolved Cell Irradiator to Study Bystander and Adaptive Responses to Low-LET Radiation. Technical Abstracts 2002 Workshop: Spatially Resolved Single Cell Irradiator to Study Bystander Responses to Low LET Radiation. Resat, M.S., Kimmel, G.A., Miller, J.H., McDonald, J.C., Murphy, M.K., Strom, D.J., Thrall, B.D., and Colson, S.D. 2001 Workshop: Spatially Resolved Single Cell Irradiator to Study Bystander Responses to Low LET Radiation. Resat, M.S., Kimmel, G.A., Miller, J.H., McDonald, J.C., Murphy, M.K., Strom, D.J., Thrall, B.D., Metting, N.F., and Colson, S.D 1999 Workshop: A Novel, Spatially Resolved Cell Irradiator to Study Bystander and Adaptive Responses to Low-LET Radiation.

117

Radiation and Chemical Risk Management [EVS Program Area]  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Radiation and Chemical Risk Management Radiation and Chemical Risk Management EVS helps meet the challenge of protecting human health and the environment through the management of risk associated with radiation and chemicals in the environment. Protecting human health, welfare, and the environment in a world affected by energy production and technology is a global challenge. EVS helps to meet this challenge through research and analysis on the management of risk associated with radiation and chemicals in the environment. To improve the management of risk associated with nuclear and chemical materials and wastes at contaminated sites, we develop information and tools that support decision making related to health, safety, environmental, economic, and social-cultural concerns. Nuclear Materials and Waste Disposition

118

Low Dose Radiation Research Program: Molecular Mechanisms of  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Molecular Mechanisms of Radiation-Induced Genomic Instability in Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Cells. Authors: Howard L. Liber1 and Jeffrey L. Schwartz2. Institutions: 1Colorado State University and 2University of Washington. Knowledge of the signal and target through which radiation induces genomic instability, which we propose to investigate herein, will allow us to model effects at low doses. Such knowledge will aid in understanding variations in the induction of this genomic instability, both among cells and among individuals. This information could also lead to more sensitive measures of instability that could yield accurate measures of instability induction at low doses. We have developed an in-vitro cell model, in which radiation-induced chromosome instability develops in a two-stage process.

119

Low Dose Radiation Research Program: Molecular Characterization of Survival  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Survival Advantage, Bystander Effect, and Survival Advantage, Bystander Effect, and Genomic Instability after Low-LET Low Dose Radiation Exposure Mohan Natarajan University of Texas Health Science Center Why this Project? To understand the molecular link between the activation of NF-kB and cellular outcomes such as better cell survival after low-LET radiation and to determine whether low dose radiation-induced NF-kB signaling can mediate telomerase activation and thus confer enhanced cell survival of normal aortic endothelial cells. Project Goals To determine whether low-linear energy transfer (LET) radiation can cause a positive feedback signal initiated by the activation of the NF-kB. To examine one of the mechanisms involving TNF-a as a signaling mediator, which could mediate the bystander effect through the generation

120

Low Dose Radiation Research Program: Linking Molecular Events to Cellular  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Linking Molecular Events to Cellular Responses at Low Dose Exposures Linking Molecular Events to Cellular Responses at Low Dose Exposures Thomas Weber Pacific Northwest National Laboratory Why This Project It currently costs billions of dollars to protect workers and the public from exposure to man-made radiation, despite exposure levels lower than the natural background levels of radiation. If it could be demonstrated that there is no increased cancer risk associated with these low dose exposures, these resources could be directed toward more critical societal issues. Defining low dose radiation cancer risks is limited by our ability to measure and directly correlate relevant cellular and molecular responses occurring at the low radiation dose and dose rate with tumor formation. This deficiency has led to conservative risk assessments based on low dose

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Low Dose Radiation Research Program: Current Funded Project Descriptions  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Funded Project Descriptions Funded Project Descriptions Effects Of Low Doses of Radiation on DNA Repair Jointly funded by NASA and DOE Eric J Ackerman Pacific Northwest National Laboratory Richland, WA 99352 Dr. Ackerman will study the effect of low doses of ionizing radiation on the repair of different types of damage to DNA, including damage from ionizing radiation and that produced by the normal internal operation of the cell. Using a very sensitive technique called host cell reactivation assay (HCR), he will quantitatively measure the repair of each type of DNA damage and thereby measure if the cellular repair system itself has been damaged. He will also determine if unique forms of DNA repair system damage are induced by low doses of cosmic radiation exposure present during space

122

Low Dose Radiation Research Program: Marianne B. Sowa  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Marianne B. Sowa Marianne B. Sowa PNNL - Pacific Northwest National Laboratory Funded Projects A Mechanistic Study of the Radiation Quality Dependence of Bystander Effects in Human Cells Technical Abstracts 2006 Workshop: Using a Low-LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation. Sowa, M.B., Goetz, W., Baulch, J., and Morgan, W.F. Morphological Changes in a 3D Mammary Model Following Exposure to Low Dose, Low-LET Radiation Opresko, L.K., Chrisler, W., Emory, K., Arthurs, B., and Sowa, M.B. 2005 Workshops: Using a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation Morgan, W.F. and Sowa, M.B. Publications Perrine, K.A., Lamarche, B.L., Hopkins, D.F., Budge, S.E., Opresko, L.K., Wiley, H.S., and Sowa, M.B. (2007). High speed method for in situ

123

Low Dose Radiation Research Program: Howard L. Liber  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Howard L. Liber Howard L. Liber Department of Environmental and Radiological Health Sciences Colorado State University Currently Funded Projects Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Cells Technical Abstracts 2003 Workshop: Delayed genomic instability in human lymphoblasts exposed to 137Cs y-rays radiation Schwartz, J.L., Jordan, R., Lenarczyk, M. and Liber, H.L. 2002 Workshop: Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Cells. Liber, H.L. and Schwartz, J.L. Publications Zhang, Y., Zhou, J., Held, K.D., Redmond, R.W., Prise, K.M., and Liber, H.L. (2008). Deficiencies of double-strand break repair factors and effects on mutagenesis in directly [gamma]-irradiated and medium-mediated bystander human lymphoblastoid cells. Radiation Research 169(2):197-206.

124

Low Dose Radiation Research Program: Janet E. Baulch  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Janet E. Baulch Janet E. Baulch University of California, Davis Currently Funded Projects Impact of Genetic Factors on the Heritable Effects of Paternal Exposure to Low-Dose Radiation Technical Abstracts 2003 Workshop: DNA damage in acutely irradiated F2 mice with a history of paternal F0 germline irradiation Baulch, J.E. and Raabe, O G. 2002 Workshop Impact of Genetic Factors on the Heritable Effects of Paternal Exposure to Low-Dose Radiation, Baulch, J.E., Ph.D. and Raabe, O.G., Ph.D. Publications Kovalchuk, O. and Baulch, J.E. (2008). Epigenetic changes and nontargeted radiation effects - Is there a link? Environmental and Molecular Mutagenesis 49(1):16-25 Laiakis, E.C., Baulch, J.E., and Morgan, W.F. (2008). Interleukin 8 exhibits a pro-mitogenic and pro-survival role in radiation induced

125

Low Dose Radiation Research Program: Project Descriptions-Archive  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Project Descriptions-Archive Project Descriptions-Archive Effects Of Low Doses of Radiation on DNA Repair Eric J Ackerman (former PNNL) (Jointly funded by NASA and DOE) Pacific Northwest National Laboratory Richland, WA Dr. Ackerman will study the effect of low doses of ionizing radiation on the repair of different types of damage to DNA, including damage from ionizing radiation and that produced by the normal internal operation of the cell. Using a very sensitive technique called host cell reactivation assay (HCR), he will quantitatively measure the repair of each type of DNA damage and thereby measure if the cellular repair system itself has been damaged. He will also determine if unique forms of DNA repair system damage are induced by low doses of cosmic radiation exposure present during space

126

Low Dose Radiation Research Program: Comparison of DNA Damage Risk from  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Comparison of DNA Damage Risk from Low-Dose Radiation and Folate Comparison of DNA Damage Risk from Low-Dose Radiation and Folate Deficiency. Authors: Chantal Courtemanche, Arnold C. Huang, Nicole Kerry, Bernice Ng, and Bruce N. Ames. Institutions: Children’s Hospital Oakland Research Institute, Oakland, California. Our overall goal is to understand and quantify the real effects of low-dose radiation by measuring direct and specific cellular changes. However, since the background dose of radiation to which most individuals are exposed is well below the levels where significant biological effects, such as mutation or tumor induction, are observed, our novel approach is to compare the consequences of radiation to those of specific nutritional deficiencies. By determining which of these two common stresses at physiologically relevant doses leads to a greater amount of DNA damage, we

127

Low Dose Radiation Research Program: Do Heritable Differences in an  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Do Heritable Differences in an Individual's Immune System Predict Do Heritable Differences in an Individual's Immune System Predict Differential Sensitivity to Low Dose Radiation Exposure? Quantitative trait loci (QTL) mapping Enlarge Image Quantitative trait loci (QTL) mapping identifies two strong candidate genes, Ptprk (Chr 10) and Acp1 (Chr 12) that are linked to genetic variation in the relative abundance of peripheral Th and Tc cells, two cell populations that are sensitive to radiation exposure at low doses. Expression of each gene is significantly altered by exposure to low dose radiation in vivo. Genome-wide scans for the ratio of %CD4+ (Th) to %CD8+ (Tc) lymphocytes were performed using genenetwork.org. The solid horizontal line represents genome-wide significance at P < 0.05, based on 1,000 permutations. LOD indicates logarithm of odds scores.

128

Low Dose Radiation Program: Links - Suggested Books and Literature for  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Suggested Books and Literature for Teachers about Radiation Suggested Books and Literature for Teachers about Radiation Popular Press News Articles Newspapers is an excellent portal or gateway to newspapers from all 50 states. To find a newspaper of interest, select a state and click Search. For a more specified search, fill in the Title of the newspaper and click Search. The newspapers available from that state are listed alphabetically. Hall, E., Radiation and Life Hall, E.J.Radiobiology for the Radiologist. 5th ed. Lippincott Williams & Wilkins, Philadelphia, PA. 2000 Nagai, T.Atomic Bomb Rescue and Relief Report. Nagasaki Association for Hibakushas' Medical Care (NASHIM), Nagasaki, Japan. 2000 Nagataki, S.Nagasaki Symposium on Chernobyl: Update and Future, Proceedings of "Chernobyl Update" 3 June 1994 at the 67th Annual Meeting of

129

Low Dose Radiation Research Program: Robert L. Ullrich  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Robert L. Ullrich Robert L. Ullrich Colorado State University Currently Funded Projects Radiation Leukemogenesis at Low Dose Rates (NSCOR) Genetic Mechanisms of Induced Chromosomal Instability and their Relationships with Radiation Tumorigenesis Technical Abstracts 2006 Workshop: The Role of Telomere Dysfunction in Driving Genomic Instability Bailey, S.M., Williams, E.S., and Ullrich, R.L. 2005 Workshop: Dsyfunctional Mammalian Telomeres in DNA-PKcs Deficient Backgrounds Bailey, S.M., Williams, E., Hagelstrom, T., and Ullrich, R.L. 2003 Workshop: Dysfunctional Mammalian Telomeres Join to Double-Strand Breaks Bailey, S.M., Goodwin, E.H., Williams, E., and Ullrich, R.L. 2002 Workshop: Dysfunctional Telomeres, Radiation-Induced Instability and Tumorigenesis Bailey, S.M., Goodwin, E.H., Cornforth, M.N., and Ullrich, R.L.

130

Low Dose Radiation Research Program: Interaction between Tissue and  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

between Tissue and Cellular Stress Responses: Effect of between Tissue and Cellular Stress Responses: Effect of TGF-ß Depletion on Radiation-Induced p53 Response M.H. Barcellos-Hoff, S.A. Ravani, R.L. Henshall, K.B. Ewan, R.L. Warters,* B. Parvin Lawrence Berkeley National Laboratory *University of Utah One of the most widely studied cellular responses to radiation is the activation of the transcription factor, p53, whose abundance and action dictates individual cellular fate decisions regarding proliferation, differentiation and death. A cell's response to damage needs to be rapid. Thus, it is not surprising that the activation of the p53 stress response primarily involves post-translational changes in the p53 protein. Whereas intracellular radiation-induced mediators of p53 stability have been the subject of intense study, little is known about the extracellular factors

131

Low Dose Radiation Research Program: Research Highlights - Collateral  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Collateral Damage Collateral Damage Using targeted irradiation to understand radiation-induced effects in bystander cells chromosomal A typical example of chromosomal instability induction measured by chromosome-type aberrations in primary human lymphocytes at delay time post-irradiation of a fraction of the cell population. Similar types of aberrations were observed in whole irradiated population but were not observed in untreated cells. Munira Kadhim Background: It has long been understood that radiation exposure can influence cellular changes. Studies indicate that even very low doses of high linear energy transfer (LET) alpha-particle irradiation, such as that from environmental radon, can affect cells. Radiation-induced genomic instability can be observed in the progeny of irradiated cells and as a

132

Low Dose Radiation Research Program: Rainer K. Sachs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Rainer K. Sachs Rainer K. Sachs University of California, Berkeley Funded Projects BIO-BASED RISK MODELING 03-20: Modeling the Interrelations Among Radiation-Induced Bystander Effects, Genomic Instability and Cancer Cytogenetic Tests of Radiobiological Models Relating Epidemiologically Measurable Risks to Low-Dose Risks Technical Abstracts 2006 Workshop The Bystander Effect in Normal Human 3-D Tissue: Experiments, Models, and Implications Brenner, D., Ponnaiya, B., Shuryak, I., Sachs, R., and Geard, D. Radiation Carcinogenesis Risk as Influenced by Intercellular Interaction Hahnfeldt, P., Hlatky, L., and Sachs, R.K. 2005 Workshop: Modelling Intercellular Interactions During Radiation Carcinogenesis Sachs, R.K., Chan, M., Hlatky, L., and Hahnfeldt, P. 2003 Workshop: Chromosome Spatial Clustering Uncovered Through Radiogenic Aberrations

133

Low Dose Radiation Research Program: Modeling Intercellular Interactions  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Modeling Intercellular Interactions During Radiation Carcinogenesis Modeling Intercellular Interactions During Radiation Carcinogenesis Authors: Rainer K Sachs,1 Michael Chan,2 Lynn Hlatky,3 Philip Hahnfeldt3 Institutions: 1Departments of Mathematics and Physics, University of California Berkeley California; 2School of Medicine, University of California at San Diego, La Jolla California; 3Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston Massachusetts Abstract By modulating the microenvironment of malignant or pre-malignant epithelial cells, inhibitory or stimulatory signals from nearby cells, including those in stromal and vascular tissues, can play a key role in carcinogenesis; cancer is ultimately a disease of a whole-cell community, not just of a single cell, clone, or cell lineage. However, current commonly used

134

Low Dose Radiation Research Program: Interaction of Genome and Cellular  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Genome and Cellular Micronenvioronment of Genome and Cellular Micronenvioronment Mina Bissell Life Sciences Division Lawrence Berkeley National Laboratory Why this Project While normal stoma can delay or prevent tumorigenesis, abnormal stromal components can promote tumor growth. Acquired or inherited mutations that alter stromal cell function can release the context-suppressed malignant cells. Literature spanning more than a century has shown that inflammation associated with tissue wounding can produce tunors. Radiation produces changes in reactive oxygen that are similar to inflammation and may represent a mechanism for radiation-induced damage. Project Goals To determine the underlying role of stromal alterations in controling genomic instability accompanying epithelial-mesenchyumal transformation.

135

Low Dose Radiation Research Program: Radiation-Induced Nuclear Factor kB  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Radiation-Induced Nuclear Factor kB mediates survival advantage by Radiation-Induced Nuclear Factor kB mediates survival advantage by Telomerase Activation. Authors: Natarajan M.,1 Mohan S.,2 Pandeswara, S.L.,1 and Herman T.S.1 Institutions: Departments of 1Radiation Oncology and 2Pathology, The University of Texas Health Science Center, San Antonio, Texas Activation of NF-kB in response to low doses of ionizing radiation was first shown in our laboratory. Although studies have shown that NF-kB plays an important role in anti-apoptotic function, little has been done to understand the molecular link between the activation of NF-kB and cellular outcome such as enhanced cell survival after low dose low-linear transfer (LET) radiation. Because upregulation of telomerase activity is associated with longevity and allows cells to escape from senescence, we hypothesize

136

Low Dose Radiation Research Program: Characterizing Bystander Effects  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Irradiation. Irradiation. Authors: L.A. Braby and J.R. Ford. Institutions: Texas A&M University. Bystander effects, which are typically seen as in increase in the cellular concentration of specific repair related molecules or as cytogenetic changes which appear to be the consequence of DNA damage, may be a significant factor in the risk of long-term health effects of low doses of radiation. These effects clearly increase the effective size of the target for radiation response, from the diameter of a single cell or cell nucleus to something significantly larger, by bringing additional cells into the process. It is unclear whether this larger target will result in an increase or a decrease in the probability of inducing a change which would be detrimental to the health of the organism, but it clearly reduces the

137

Low Dose Radiation Research Program: Molecular Mechanisms of  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Cells Howard L. Liber Department of Environmental and Radiological Health Sciences Colorado State University Why This Project This research will be to investigate the condition known as genomic instability. This can be defined as a state in which genetic alterations, including chromosome aberrations and gene mutations, occur at rates that are much higher than normal. In fact, genomic instability is what allows a normal cell to accumulate the multiple genetic alterations that are required to convert it into a cancer cell. The chromosomes of human cells have structures at their ends called telomeres. Telomeres normally function to prevent chromosomes from fusing together end-to-end. An important

138

Low Dose Radiation Research Program: The Progeny of Irradiated Mammary  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Progeny of Irradiated Mammary Epithelial Cells Exhibit a Phenotype Progeny of Irradiated Mammary Epithelial Cells Exhibit a Phenotype Characteristic of Malignancy Mary H. Barcellos-Hoff, R.L. Henshall-Powell, M.J. Bissell, and B. Parvin Lawrence Berkeley National Laboratory, Life Sciences Division We have proposed that the ability of radiation to induce altered microenvironments affects the frequency and features of neoplastic progression. Thus, we have sought to characterize the irradiated microenvironment and determine how these events contribute to mammary carcinogenesis. By using imaging bioinformatics to analyze mouse and human models of breast cancer we have now examined cell adhesion molecules (CAMs) critical for tissue-specific organization and function. We found that 1) radiation-induced microenvironments can contribute to neoplastic potential

139

Low Dose Radiation Research Program: Genetic Mechanisms of Induced  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mechanisms of Induced Chromosomal Instability and their Mechanisms of Induced Chromosomal Instability and their Relationships with Radiation Tumorigenesis Robert Ullrich Colorado State University Why This Project A combination of epidemiological, experimental, animal, and cellular molecular data is used in the estimation of tumor risk after low doses of low-LET radiation. Uncertainties are recognized in the interpretation of all these data sets, and recent findings concerning genomic instability in irradiated cells challenge the conventional view that induced DNA damage is expressed during the immediate post-irradiation cell cycle. These data on genomic instability are based largely upon studies of cell cultures the mechanisms involved and implications for tumor formation in living organisms remain unclear. Nevertheless, if induced genomic instability were

140

Low Dose Radiation Research Program: Cooperation Between Homologous  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Cooperation Between Homologous Recombination and the Fanconi Anemia Cooperation Between Homologous Recombination and the Fanconi Anemia Cancer Suppressor Proteins in Minimizing Spontaneous and Radiation-Induced Chromosomal Instability Authors: Larry H. Thompson, John M. Hinz, Robert S. Tebbs, and N. Alice Yamada Institutions: Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, California Purpose and experimental approach. This study addresses the genetic basis of spontaneous mutagenesis as a means of understanding the DNA damage-response pathways that maintain chromosome stability. It is our view that knowledge of these processes is fundamental to understanding how low dose ionizing radiation (IR) produces chromosomal rearrangements that lead to carcinogenesis. Endogenous oxidative DNA damage is presumed to be a

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Biological dosimetry assessments of a serious radiation accident in Bulgaria in 2011  

Science Journals Connector (OSTI)

......Protection and Nuclear Safety (IRSN). REFERENCES...and Response to Radiation Emergencies Emergency...Dose estimation software for radiation biodosimetry. Health...and Treatment of Radiation Injuries. (1998) Safety Reports Series No......

E. Grgoire; V. Hadjidekova; R. Hristova; G. Gruel; S. Roch-Lefevre; P. Voisin; A. Staynova; S. Deleva; E. A. Ainsbury; D. C. Lloyd; J. F. Barquinero

2013-08-01T23:59:59.000Z

142

Low Dose Radiation Research Program: Jian Jian Li  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Jian Jian Li Jian Jian Li School of Health Sciences, Purdue University Newly Funded Projects Regulation of NF-kB and Mn SOD in Low Dose Radiation-Induced Adaptive Responses in Mouse and Human Skin Cells, abstract, description. Technical Abstracts 2006 Workshops: NF-kB Mediated Signaling Network in Low Dose X-Ray Induced Adaptive Protection on Mouse and Human Skin Epithelial Cells Ahmed, K.M., Fan, M., Spitz, and Li, J.J. 2005 Workshops: Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Ionizing Radiation: Induction of NF-κB, MnSOD, 14-3-3ζ and Cyclin B1. Li, J.J., Ahmed, K.M., Fan, M., Dong, S., Spitz, D.R., and Yu, C.-R. 2003 Workshops: Gene Expression Profiles of Human Skin Keratinocytes Exposed to Acute and Chronic Ionizing Radiation Li, J.J., Ozeki, M., Wang, T., Tamae, D., Nelson, D., Wyrobek, A., and

143

A Mechanism-Based Approach to Predict the Relative Biological Effectiveness of Protons and Carbon Ions in Radiation Therapy  

SciTech Connect (OSTI)

Purpose: The physical and potential biological advantages of proton and carbon ions have not been fully exploited in radiation therapy for the treatment of cancer. In this work, an approach to predict proton and carbon ion relative biological effectiveness (RBE) in a representative spread-out Bragg peak (SOBP) is derived using the repair-misrepair-fixation (RMF) model. Methods and Materials: Formulas linking dose-averaged linear-quadratic parameters to DSB induction and processing are derived from the RMF model. The Monte Carlo Damage Simulation (MCDS) software is used to quantify the effects of radiation quality on the induction of DNA double-strand breaks (DSB). Trends in parameters {alpha} and {beta} for clinically relevant proton and carbon ion kinetic energies are determined. Results: Proton and carbon ion RBE are shown to increase as particle energy, dose, and tissue {alpha}/{beta} ratios decrease. Entrance RBE is {approx}1.0 and {approx}1.3 for protons and carbon ions, respectively. For doses in the range of 0.5 to 10 Gy, proton RBE ranges from 1.02 (proximal edge) to 1.4 (distal edge). Over the same dose range, the RBE for carbon ions ranges from 1.5 on the proximal edge to 6.7 on the distal edge. Conclusions: The proposed approach is advantageous because the RBE for clinically relevant particle distributions is guided by well-established physical and biological (track structure) considerations. The use of an independently tested Monte Carlo model to predict the effects of radiation quality on DSB induction also minimizes the number of ad hoc biological parameters that must be determined to predict RBE. Large variations in predicted RBE across an SOBP may produce undesirable biological hot and cold spots. These results highlight the potential for the optimization of physical dose for a uniform biological effect.

Frese, Malte C. [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Department of Medical Physics in Radiation Oncology, German Cancer Research Center, Heidelberg (Germany); Yu, Victor K. [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States); Stewart, Robert D. [Department of Radiation Oncology, University of Washington, Seattle, Washington (United States); Carlson, David J., E-mail: david.j.carlson@yale.edu [Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut (United States)

2012-05-01T23:59:59.000Z

144

Modeling marrow damage from response data: Morphallaxis from radiation biology to benzene toxicity  

SciTech Connect (OSTI)

Consensus principles from radiation biology were used to describe a generic set of nonlinear, first-order differential equations for modeling of toxicity-induced compensatory cell kinetics in terms of sublethal injury, repair, direct killing, killing of cells with unrepaired sublethal injury, and repopulation. This cellular model was linked to a probit model of hematopoietic mortality that describes death from infection and/or hemorrhage between {approximately} 5 and 30 days. Mortality data from 27 experiments with 851 doseresponse groups, in which doses were protracted by rate and/or fractionation, were used to simultaneously estimate all rate constants by maximum-likelihood methods. Data used represented 18,940 test animals distributed according to: (mice, 12,827); (rats, 2,925); (sheep, 1,676); (swine, 829); (dogs, 479); and (burros, 204). Although a long-term, repopulating hematopoietic stem cell is ancestral to all lineages needed to restore normal homeostasis, the dose-response data from the protracted irradiations indicate clearly that the particular lineage that is ``critical`` to hematopoietic recovery does not resemble stem-like cells with regard to radiosensitivity and repopulation rates. Instead, the weakest link in the chain of hematopoiesis was found to have an intrinsic radioresistance equal to or greater than stromal cells and to repopulate at the same rates. Model validation has been achieved by predicting the LD{sub 50} and/or fractional group mortality in 38 protracted-dose experiments (rats and mice) that were not used in the fitting of model coefficients.

Jones, T.D.; Morris, M.D.; Hasan, J.S.

1995-12-01T23:59:59.000Z

145

Atmospheric radiation measurement program facilities newsletter, June 2002.  

SciTech Connect (OSTI)

ARM Intensive Operational Period Scheduled to Validate New NASA Satellite--Beginning in July, all three ARM sites (Southern Great Plains [SGP], North Slope of Alaska, and Tropical Western Pacific; Figure 1) will participate in the AIRS Validation IOP. This three-month intensive operational period (IOP) will validate data collected by the satellite-based Atmospheric Infrared Sounder (AIRS) recently launched into space. On May 4, the National Aeronautics and Space Administration (NASA) launched Aqua, the second spacecraft in the Earth Observing System (EOS) series. The EOS satellites monitor Earth systems including land surfaces, oceans, the atmosphere, and ice cover. The first EOS satellite, named Terra, was launched in December 1999. The second EOS satellite is named Aqua because its primary focus is understanding Earth's water cycle through observation of atmospheric moisture, clouds, temperature, ocean surface, precipitation, and soil moisture. One of the instruments aboard Aqua is the AIRS, built by the Jet Propulsion Laboratory, a NASA agency. The AIRS Validation IOP complements the ARM mission to improve understanding of the interactions of clouds and atmospheric moisture with solar radiation and their influence on weather and climate. In support of satellite validation IOP, ARM will launch dedicated radiosondes at all three ARM sites while the Aqua satellite with the AIRS instrument is orbiting overhead. These radiosonde launches will occur 45 minutes and 5 minutes before selected satellite overpasses. In addition, visiting scientists from the Jet Propulsion Laboratory will launch special radiosondes to measure ozone and humidity over the SGP site. All launches will generate ground-truth data to validate satellite data collected simultaneously. Data gathered daily by ARM meteorological and solar radiation instruments will complete the validation data sets. Data from Aqua-based instruments, including AIRS, will aid in weather forecasting, climate modeling, and greenhouse gas studies. These instruments will provide more accurate, detailed global observations of weather and atmospheric parameters that will, in turn, improve the accuracy and quality of weather forecasts. A satellite-based instrument is cost-effective because it can provide continuous global measurements, eliminating isolated yet costly weather balloon releases. Aqua, launched from Vandenberg Air Force Base in California (Figure 2), carries six state-of-the-art instruments that measure various water vapor parameters: (1) AIRS, which measures atmospheric temperature and humidity, land and sea surface temperatures, cloud properties, and radiative energy flux; (2) Advanced Microwave Sounding Unit, which measures atmospheric temperature and humidity during both cloudy and cloud-free periods; (3) Advanced Microwave Scanning Radiometer, which measures cloud properties, radiative energy flux, precipitation rates, land surface wetness, sea ice, snow cover, sea surface temperature, and wind fields; (4) Clouds and the Earth's Radiant Energy System, which measures radiative energy flux; (5) Humidity Sounder for Brazil, which measures atmospheric humidity by using a passive scanning microwave radiometer; and (6) Moderate Resolution Imaging Spectroradiometer, which measures cloud properties, radiative energy flux, aerosol properties, land cover and land use change, vegetation dynamics, land surface temperature, fire occurrence, volcanic effects, sea surface temperature, ocean color, snow cover, atmospheric temperature and humidity, and sea ice. The data-gathering capabilities of the Aqua instruments will provide an unprecedented view of atmosphere-land interactions (Figure 3). The availability of more frequent, more accurate global measurements of important atmospheric parameters will both improve our capabilities for short-term weather forecasting and lead to a better understanding of climate variability and climate change. Simultaneous measurements of many parameters will allow scientists to study complicated forcings and feedbacks of the atmosphere, which can be

Holdridge, D. J.

2002-07-03T23:59:59.000Z

146

Atmospheric Radiation Measurement Program Climate Research Facility Operations  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

1 1 Atmospheric Radiation Measurement Climate Research Facility Operations Quarterly Report October 1-December 31, 2011 DISCLAIMER This report was prepared as an account of work sponsored by the U.S. Government. Neither the United States nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or

147

Atmospheric Radiation Measurement Program Climate Research Facility Operations  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

7 7 Atmospheric Radiation Measurement Climate Research Facility Operations Quarterly Report January 1-March 31, 2012 DISCLAIMER This report was prepared as an account of work sponsored by the U.S. Government. Neither the United States nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or

148

Modeling the Action of Protons and Heavier Ions in Biological Targets: Nuclear Interactions in Hadrontherapy and Space Radiation Protection  

Science Journals Connector (OSTI)

Tumor treatment with protons and Carbon ions can allow for a better optimization of Tumor Control Probability and Normal Tissue Complication Probability especially for radio?resistant tumors. Exposure to protons and heavier ions is also of concern for manned space missions such as future travels to the Moon and Mars. Nuclear reactions with the human body constituents the beam line components (for hadrontherapy) and the spacecraft walls and shielding (for space radiation protection) can significantly modify the characteristics of the primary radiation field and thus the dose distributions in the various target tissues. In this context the FLUKA Monte Carlo transport code integrated with radiobiological data and coupled with anthropomorphic phantoms was applied to the characterization of therapeutic proton beams and the calculation of space radiation organ doses with focus on the role of nuclear interactions. Besides absorbed and equivalent doses distributions of biological dose (modeled as the average number of DNA clustered lesions per cell induced in a given organ or tissue) were calculated as well. Concerning space radiation protection exposure to Galactic Cosmic Rays (GCR) and Solar Particle Events (SPE) under different shielding conditions was simulated. Both for hadrontherapy and for space radiation exposure nuclear reaction products were found to play a more important role for the equivalent and biological dose than for the absorbed dose. Furthermore while for SPEs the doses (both absorbed and equivalent/biological) decreased dramatically by increasing the shield thickness the GCR doses showed a slight shielding dependence. Overall these examples of application of FLUKA to radiotherapy and radiation protection problems emphasized the need of further models and data typically double?differential cross sections for nucleus?nucleus interactions at energies below a few hundred MeV/n.

F. Ballarini; G. Battistoni; F. Cerutti; E. Gadioli; M. V. Garzelli; A. Ottolenghi; V. Parini; M. Pelliccioni; P. Sala; D. Scannicchio

2005-01-01T23:59:59.000Z

149

Steel Creek fish, L-Lake/Steel Creek Biological Monitoring Program, January 1986--December 1991  

SciTech Connect (OSTI)

The Savannah River Site (SRS) encompasses 300 sq mi of the Atlantic Coastal plain in west-central South Carolina. The Savannah River forms the western boundary of the site. Five major tributaries of the Savannah River -- Upper Three Runs Creek, Four Mile Creek, Pen Branch, Steel Creek, and Lower Three Runs Creek -- drain the site. All but Upper Three Runs Creek receive, or in the past received, thermal effluents from nuclear production reactors. In 1985, L Lake, a 400-hectare cooling reservoir, was built on the upper reaches of Steel Creek to receive effluent from the restart of L-Reactor, and protect the lower reaches from thermal impacts. The lake has an average width of approximately 600 m and extends along the Steel Creek valley approximately 7000 m from the dam to the headwaters. Water level is maintained at a normal pool elevation of 58 m above mean sea level by overflow into a vertical intake tower that has multilevel discharge gates. The intake tower is connected to a horizontal conduit that passes through the dam and releases water into Steel Creek. The Steel Creek Biological Monitoring Program was designed to meet environmental regulatory requirements associated with the restart of L-Reactor and complements the Biological Monitoring Program for L Lake. This extensive program was implemented to address portions of Section 316(a) of the Clean Water Act. The Department of Energy (DOE) must demonstrate that the operation of L-Reactor will not significantly alter the established aquatic ecosystems.

Sayers, R.E. Jr.; Mealing, H.G. III [Normandeau Associates, Inc., New Ellenton, SC (United States)

1992-04-01T23:59:59.000Z

150

Low Dose Radiation Research Program: Effects of Low Doses of Radiation on  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Low Doses of Radiation on DNA Repair Low Doses of Radiation on DNA Repair Eric Ackerman Pacific Northwest National Laboratory Why this Project? Even low doses (0.1 Gy) exert measurable effects on DNA repair. The first-known oxidative lesion repaired only by nucleotide excision repair found in normal cells is cyclo-dA. This lesion is found in normal cells and thought to be a byproduct of oxidative metabolism. When this lesion occurs, it stimulates repair. If repair is stimulated by low dose radiation, there are some implications for human health. For example, do some individuals exhibit a greater, lower, or no stimulation to certain DNA lesions? If there are population polymorphism that influence DNA repair, then it would be possible to use our assay for screening individuals for repair sensitivity.

151

Low Dose Radiation Research Program: Low Dose Ionizing Radiation-Induced  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Low Dose Ionizing Radiation-Induced Effects in Irradiated and Low Dose Ionizing Radiation-Induced Effects in Irradiated and Unirradiated cells: Pathways Analysis in Support of Risk Assessment. Authors: B.E. Lehnert, R. Cary, D. Gadbois, and G. Gupta. Institutions: Bioscience Division, Los Alamos National Laboratory. The scientific literature presents a confusing picture concerning health risks due to low dose ionizing radiation (LDIR), e.g., <1-10 cGy. Some effects of LDIR such as enhanced rates of cell proliferation and the induction of radioadaptation may be benign under some circumstances. Other evidence suggests LDIR can be hazardous and that a threshold for potentially detrimental responses, e.g., increases in intracellular reactive oxygen species (ROS), increases in sister chromatid exchanges (SCE), alterations in gene or protein expression profiles, and increased

152

Low Dose Radiation Research Program: Effects of Low Doses of Radiation on  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Abstract Abstract Title: Effects of Low Doses of Radiation on DNA Repair (PNNL Project # 42699) Authors: Eric J. Ackerman, Ph.D. Institutions: Pacific Northwest National Laboratory Richland, WA We developed a functional assay to measure the effects of LDR on repair of many different lesions representative of those found in cells as consequences of normal oxidative metabolism, as well as those caused by radiation. Currently only 1/10th attomole =105 damaged molecules/cell and 3000 cells/measurement are required. We have found that even low doses (10 rad) exert measurable effects on DNA repair. Interestingly, the amount of DNA repair increases at 10-50 rads, plateaus, and then increases even further at higher doses well below doses where radiation-induced lethality

153

Physical and biological properties of U.S. standard endotoxin EC after exposure to ionizing radiation.  

Science Journals Connector (OSTI)

...in the UV range, radiation treatment...pattern. Dose-related...effects of the ionizing radiation...milligram-per-milliliter range) (13...in the UV range, we found...ioniz- ing radiation. Regarding...effective, dose- dependent...EXPOSED TO IONIZING RADIATION...

G Csako; R J Elin; H D Hochstein; C M Tsai

1983-07-01T23:59:59.000Z

154

Atmospheric radiation measurement unmanned aerospace vehicle (ARM-UAV) program  

SciTech Connect (OSTI)

ARM-UAV is part of the multi-agency U.S. Global Change Research Program and is addressing the largest source of uncertainty in predicting climatic response: the interaction of clouds and the sun`s energy in the Earth`s atmosphere. An important aspect of the program is the use of unmanned aerospace vehicles (UAVs) as the primary airborne platform. The ARM-UAV Program has completed two major flight series: The first series conducted in April, 1994, using an existing UAV (the General Atomics Gnat 750) consisted of eight highly successful flights at the DOE climate site in Oklahoma. The second series conducted in September/October, 1995, using two piloted aircraft (Egrett and Twin Otter), featured simultaneous measurements above and below clouds and in clear sky. Additional flight series are planned to continue study of the cloudy and clear sky energy budget in the Spring and Fall of 1996 over the DOE climate site in Oklahoma. 3 refs., 4 figs., 1 tab.

Bolton, W.R. [Sandia National Laboratories, Livermore, CA (United States)

1996-11-01T23:59:59.000Z

155

Low Dose Radiation Research Program: Mating-Type Regulation of  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mating-Type Regulation of Non-homologous End Joining in Mating-Type Regulation of Non-homologous End Joining in Saccharomyces cerevisiae Authors: Maria Valencia,* Marc Bentele,^ Moreshwar B. Vaze,* Gernot Herrmann, Ellayhu Kraus, Sang Eun Lee, Primo Schar,^ and James E. Haber* Institutions: *Rosenstiel Center and Department of Biology, Brandeis University ^Institute of Medical Radiobiology, University of Zurich, Zurich, Switzerland. In the budding yeast, Saccharomyces cerevisiae, broken DNA ends can be ligated, either in a precise or an error-prone manner by a process known as Non-Homologous End Joining (NHEJ). Several proteins have been identified that play a role in NHEJ: the yKu70/80 heterodimer, DNA ligase IV and its associated protein Lif1/Xrcc4, the Mre11-Rad50-Xrs2 complex, as well as the silencing proteins Sir 2, 3, 4. Recent studies suggest that SIR genes may

156

Biological Systems for Hydrogen Photoproduction - DOE Hydrogen and Fuel Cells Program FY 2012 Annual Progress Report  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

3 3 FY 2012 Annual Progress Report DOE Hydrogen and Fuel Cells Program Maria L. Ghirardi (Primary Contact), Paul W. King, Kathleen Ratcliff and David Mulder National Renewable Energy Laboratory (NREL) 1617 Cole Blvd. Golden, CO 80401 Phone: (303) 384-6312 Email: maria.ghirardi@nrel.gov DOE Manager Eric Miller Phone: (202) 287-5829 Email: Eric.Miller@hq.doe.gov Subcontractors: * Dr. Sergey Kosourov, Institute of Basic Biological Problems, RAS, Pushchino, Russia * Dr. Eric Johnson, Johns Hopkins University, Baltimore, MD Project Start Date: October 1, 2000 Project End Date: Project continuation and direction determined annually by DOE Fiscal Year (FY) 2012 Primary Objectives

157

Low Dose Radiation Research Program: Research Highlights - Real-time  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Real-time imaging of repair processes possible with Nickel-63 Real-time imaging of repair processes possible with Nickel-63 microirradiator Microscope Microscope stage-mounted microirradiation system. (A) Overall system shown mounted on a micromanipulator housed within a heated, humidified, environmental chamber of a microscope. (B) Close-up showing attachment of device to the micromanipulator. (C) Detail showing the bend in the enclosing capillary, which allows positioning of the active surface directly above the target cell. (D) Microirradiator tip in dissecting microscope. (E) Close-up view through microscope optics (scale bar, 10 microns.) Background: Scientists know that mammalian cells begin a nucleoplasmic repair process within seconds after being exposed to ionizing radiation. Real-time imaging of this process could further understanding of the

158

Low Dose Radiation Research Program: Multi-cellular Crosstalk in Radiation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

About this Project About this Project Multi-cellular Crosstalk in Radiation Damage Technical Abstracts 2006 Workshop: Low-LET Bystander Effects in Cells In Vitro Are Significantly Less Than Published For High-LET Radiation Blakely, E.A., Thompson, A.C., Chang, P., Schwarz, R.I., Bjornstad, K., Rosen, C., Wisnewski, C., and Mocherla, D. 2005 Workshop: X-ray Microbeam Bystander Studies with Human Mammary Epithelial Cells and Fibroblasts Blakely, E.A., Schwarz, R.I., Thompson, A.C., Bjornstad, K.A., Chang, P.Y., Rosen, C.J., Sudar, D., Romano, R., and Parvin, B. 2003 Workshop: 12.5 keV X-ray Microbeam Bystander Studies with Human Mammary Epithelial Cells and Fibroblasts Blakely, E.A., Schwarz, R.I., Thompson, A.C., Bjornstad, K.A., Chang, P.Y., Rosen, C.J., and Sudar, D. 2001 Workshop:

159

Review of Radiation Protection Program Implementation at the Idaho Site, November 2012  

Broader source: Energy.gov (indexed) [DOE]

May 2011 May 2011 Independent Oversight Review of Radiation Protection Program Implementation at the Idaho Site November 2012 Office of Safety and Emergency Management Evaluations Office of Enforcement and Oversight Office of Health, Safety and Security U.S. Department of Energy Table of Contents 1.0 Purpose ................................................................................................................................................... 1 2.0 Scope...................................................................................................................................................... 1 3.0 Background ............................................................................................................................................ 2

160

Review of Radiation Protection Program Implementation at the Idaho Site, November 2012  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

11 11 Independent Oversight Review of Radiation Protection Program Implementation at the Idaho Site November 2012 Office of Safety and Emergency Management Evaluations Office of Enforcement and Oversight Office of Health, Safety and Security U.S. Department of Energy Table of Contents 1.0 Purpose ................................................................................................................................................... 1 2.0 Scope...................................................................................................................................................... 1 3.0 Background ............................................................................................................................................ 2

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Nuclear Engineering & Radiation Health Physics Program Outcomes Ability to apply knowledge of mathematics, science, and engineering  

E-Print Network [OSTI]

Nuclear Engineering & Radiation Health Physics Program Outcomes · Ability to apply knowledge for engineering practice · Ability to apply knowledge of atomic and nuclear physics to nuclear and radiological of mathematics, science, and engineering · Ability to design and conduct experiments as well as analyze

Tullos, Desiree

162

DOE Order Self Study Modules - DOE G 441.1-1C Radiation Protection Programs Guide  

Broader source: Energy.gov (indexed) [DOE]

41.1-1C 41.1-1C RADIATION PROTECTION PROGRAMS GUIDE NATIONAL NUCLEAR SECURITY ADMINISTRATION LEARNING AND CAREER DEVELOPMENT DEPARTMENT Change No: 1 DOE G 441.1-1C Level: Familiar Date: 12/1/08 1 DOE G 441.1-1C, RADIATION PROTECTION PROGRAMS GUIDE FAMILIAR LEVEL _________________________________________________________________________ OBJECTIVES Given the familiar level of this module and the resources listed below, you will be able to 1. Match radiation protection-related terms to their definitions; 2. Discuss the elements that should be taken into consideration to determine the likelihood of an individual receiving a dose in excess of a regulatory monitoring threshold; 3. Give three examples of criteria that should trigger a formal as-low-as-is-

163

Low Dose Radiation Research Program: Low Dose Response of Respiratory Cells  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Low Dose Radiation Research Program: Low Dose Response of Respiratory Low Dose Radiation Research Program: Low Dose Response of Respiratory Cells in Intact Tissues and Reconstituted Tissue Constructs Authors: John Ford, Amy Maslowski, Alex Redd and Les Braby Institutions: Texas A&M University, College Station, TX We are developing a model of respiratory tissue using a perfusion culture system. We are using this system to quantify the effects of normal tissue architecture, and the interaction of epithelial cells with other cell types, on radiation-induced bystander effects. Tracheal tissue taken from young adult Fischer 344 rats is imbedded in a growth factor enriched agarose matrix. The chamber is designed to allow growth medium to periodically wash the epithelial surface of the tracheal lumen while maintaining the air-interface that is necessary for the normal

164

Low Dose Radiation Research Program: Research Highlights - 2010  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

DNA Double-Strand Break Repair Capacities Before and After Exposure to Low DNA Double-Strand Break Repair Capacities Before and After Exposure to Low Dose Radiation Immunochemical detection of DSB foci in the nuclei of human fibroblasts. (A) γ-H2AX phospho-serine 139 foci (chromatin marker of DSBs; green). (B) ataxia-telangiectasia mutated phospho-serine 1981 foci (ATM, DNA damage-responsive kinase; red). (C) Merge of images A and B. (White arrows mark large γ-H2AX foci and coincident γ-H2AX/pATM foci that were positively scored; yellow arrows mark small γ-H2AX foci that lack corresponding pATM foci that were not scored.) Enlarge Image Immunochemical detection of DSB foci in the nuclei of human fibroblasts. (A) γ-H2AX phospho-serine 139 foci (chromatin marker of DSBs; green). (B) ataxia-telangiectasia mutated phospho-serine 1981 foci (ATM,

165

Oak Ridge Gaseous Diffusion Plant Biological Monitoring and Abatement Program for Mitchell Branch  

SciTech Connect (OSTI)

A proposed Biological Monitoring and Abatement Program (BMAP) for the Oak Ridge Gaseous Diffusion Plant (ORGDP; currently the Oak Ridge K-25 Site) was prepared in December 1986, as required by the modified National Pollutant Discharge Elimination System (NPDES) permit that was issued on September 11, 1986. The effluent discharges to Mitchell Branch are complex, consisting of trace elements, organic chemicals, and radionuclides in addition to various conventional pollutants. Moreover, the composition of these effluent streams will be changing over time as various pollution abatement measures are implemented over the next several years. Although contaminant inputs to the stream originate primarily as point sources from existing plant operations, area sources, such as the classified burial grounds and the K-1407-C holding pond, can not be eliminated as potential sources of contaminants. The proposed BMAP consists of four tasks. These tasks include (1) ambient toxicity testing, (2) bioaccumulation studies, (3) biological indicator studies, and (4) ecological surveys of the benthic invertebrate and fish communities. BMAP will determine whether the effluent limits established for ORGDP protect the designated use of the receiving stream (Mitchell Branch) for growth and propagation of fish and aquatic life. Another objective of the program is to document the ecological effects resulting from various pollution abatement projects, such as the Central Neutralization Facility.

Loar, J.M.; Adams, S.M.; Kszos, L.A.; Ryon, M.G.; Smith, J.G.; Southworth, G.R.; Stewart, A.J.

1992-01-01T23:59:59.000Z

166

Low Dose Radiation Research Program: Role of TNF-α as a Potential  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Role of TNF-α as a Potential Signaling Mediator of Role of TNF-α as a Potential Signaling Mediator of Radiation-Induced Bystander Effect in Human Vascular Cells. Authors: Mohan Natarajan, Sumathy Mohan, Catherine Gibbons, Yan Bo and Munira A. Kadhim Institutions: Departments of Radiation Oncology and Pathology, University of Texas Health Science Center, San Antonio, Texas; Environmental Toxicology Graduate Program, University of California, Riverside; Radiation and Genomic Stability Unit, Medical research Council, Oxford, United Kingdom Identifying reliable and sensitive signaling pathways that are implicated in adverse health effects after exposure to low doses of ionizing radiation would allow us to understand the scientific basis of low dose-induced signaling pathways and their downstream phenotypic expression. This

167

Atmospheric Radiation Measurement Program facilities newsletter, November 2002.  

SciTech Connect (OSTI)

Fall 2002 Intensive Operation Periods: Single Column Model and Unmanned Aerospace Vehicle--In an Intensive Operation Period (IOP) on November 3-23, 2002, researchers at the SGP CART site are collecting a detailed data set for use in improving the Single Column Model (SCM), a scaled-down climate model. The SCM represents one vertical column of air above Earth's surface and requires less computation time than a full-scale global climate model. Researchers first use the SCM to efficiently improve submodels of clouds, solar radiation transfer, and atmosphere-surface interactions, then implement the results in large-scale global models. With measured values for a starting point, the SCM predicts atmospheric variables during prescribed time periods. A computer calculates values for such quantities as the amount of solar radiation reaching the surface and predicts how clouds will evolve and interact with incoming light from the sun. Researchers compare the SCM's predictions with actual measurements made during the IOP, then adjust the submodels to make predictions more reliable. A second IOP conducted concurrently with the SCM IOP involves high-altitude, long-duration aircraft flights. The original plan was to use an unmanned aerospace vehicle (UAV), but the National Aeronautics and Space Administration (NASA) aircraft Proteus will be substituted because all UAVs have been deployed elsewhere. The UAV is a small, instrument-equipped, remote-control plane that is operated from the ground by a computer. The Proteus is a manned aircraft, originally designed to carry telecommunications relay equipment, that can be reconfigured for uses such as reconnaissance and surveillance, commercial imaging, launching of small space satellites, and atmospheric research. The plane is designed for two on-board pilots in a pressurized cabin, flying to altitudes up to 65,000 feet for as long as 18 hours. The Proteus has a variable wingspan of 77-92 feet and is 56 feet long. The plane can carry up to 7,260 pounds of equipment, making it a versatile research tool. The Proteus is making measurements at the very top of the cirrus cloud layer to characterize structures of these clouds. These new measurements will provide more accurate, more abundant data for use in improving the representation of clouds in the SCM. 2002-2003 Winter Weather Forecast--Top climate forecasters at the National Oceanic and Atmospheric Administration's (NOAA's) Climate Prediction Center say that an El Nino condition in the tropical Pacific Ocean will influence our winter weather this year. Although this El Nino is not as strong as the event of the 1997-1998 winter season, the United States will nevertheless experience some atypical weather. Strong impacts could be felt in several areas. Nationally, forecasters are predicting warmer-than-average temperatures over the northern tier of states and wetter-than-average conditions in the southern tier of states during the 2002-2003 winter season. Kansas residents should expect warmer and wetter conditions, while Oklahoma will be wetter than average.

Holdridge, D. J.

2002-12-03T23:59:59.000Z

168

Management and Administration of Radiation Protection Programs Guide for use with Title 10, Code of Federal Regulations, Part 835, Occupational Radiation Protection  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

This Guide discusses acceptable methods for ensuring that radiological activities will be managed and administered in accordance with a documented radiation protection program that complies with U.S. DOE requirements specified in Title 10 CFR Part 835, Occupational Radiation Protection. Cancels DOE G 441.1-1. Canceled by DOE G 441.1-1B.

2003-10-20T23:59:59.000Z

169

SASSIE: A program to study intrinsically disordered biological molecules and macromolecular ensembles using experimental scattering restraints  

Science Journals Connector (OSTI)

A program to construct ensembles of biomolecular structures that are consistent with experimental scattering data are described. Specifically, we generate an ensemble of biomolecular structures by varying sets of backbone dihedral angles that are then filtered using experimentally determined restraints to rapidly determine structures that have scattering profiles that are consistent with scattering data. We discuss an application of these tools to predict a set of structures for the HIV-1 Gag protein, an intrinsically disordered protein, that are consistent with small-angle neutron scattering experimental data. We have assembled these algorithms into a program called SASSIE for structure generation, visualization, and analysis of intrinsically disordered proteins and other macromolecular ensembles using neutron and X-ray scattering restraints. Program summary Program title: SASSIE Catalogue identifier: AEKL_v1_0 Program summary URL: http://cpc.cs.qub.ac.uk/summaries/AEKL_v1_0.html Program obtainable from: CPC Program Library, Queen?s University, Belfast, N. Ireland Licensing provisions: GNU General Public License v3 No. of lines in distributed program, including test data, etc.: 3?991?624 No. of bytes in distributed program, including test data, etc.: 826 Distribution format: tar.gz Programming language: Python, C/C++, Fortran Computer: PC/Mac Operating system: 32- and 64-bit Linux (Ubuntu 10.04, Centos 5.6) and Mac OS X (10.6.6) RAM: 1 GB Classification: 3 External routines: Python 2.6.5, numpy 1.4.0, swig 1.3.40, scipy 0.8.0, Gnuplot-py-1.8, Tcl 8.5, Tk 8.5, Mac installation requires aquaterm 1.0 (or X window system) and Xcode 3 development tools. Nature of problem: Open source software to generate structures of disordered biological molecules that subsequently allow for the comparison of computational and experimental results is limiting the use of scattering resources. Solution method: Starting with an all atom model of a protein, for example, users can input regions to vary dihedral angles, ensembles of structures can be generated. Additionally, simple two-body rigid-body rotations are supported with and without disordered regions. Generated structures can then be used to calculate small-angle scattering profiles which can then be filtered against experimentally determined data. Filtered structures can be visualized individually or as an ensemble using density plots. In the modular and expandable program framework the user can easily access our subroutines and structural coordinates can be easily obtained for study using other computational physics methods. Additional comments: The distribution file for this program is over 159 Mbytes and therefore is not delivered directly when download or Email is requested. Instead an html file giving details of how the program can be obtained is sent. Running time: Varies depending on application. Typically 10 minutes to 24 hours depending on the number of generated structures. References:[1] M.S. Kent, J.K. Murton, S. Satija, B. Akgun, H. Nanda, J.E. Curtis, J. Majewski, J.R. Engen, C.R. Morgan, Neutron reflectivity study of the conformation of HIV nef bound to lipid membranes, Biophys. J. 99 (6) (2010) 19401948. [2] H. Nanda, S.A.K. Datta, F. Heinrich, M. Losche, A. Rein, S. Krueger, J.E. Curtis, Electrostatic interactions and binding orientation of HIV-1 matrix, studied by neutron reflectivity, Biophys. J. 99 (7) (2010) 25162524. [3] S.A.K. Datta, J.E. Curtis, W. Ratcli, P.K. Clark, R.M. Crist, J. Lebowitz, S. Krueger, A. Rein, Conformation of the HIV-1 Gag protein in solution, J. Mol. Biol. 365 (3) (2007) 812824.

Joseph E. Curtis; Sindhu Raghunandan; Hirsh Nanda; Susan Krueger

2012-01-01T23:59:59.000Z

170

Yucca Mountain Biological Resources Monitoring Program. Progress report, January 1994--December 1994  

SciTech Connect (OSTI)

The US Department of Energy (DOE) is required by the Nuclear Waste Policy Act of 1982 (as amended in 1987) to study and characterize the suitability of Yucca Mountain as a potential geological repository for high-level nuclear waste. During site characterization, the DOE will conduct a variety of geotechnical, geochemical, geological, and hydrological studies to determine the suitability of Yucca Mountain as a potential repository. To ensure that site characterization activities do not adversely affect the environment at Yucca Mountain, a program has been implemented to monitor and mitigate potential impacts and ensure activities comply with applicable environmental regulations. This report describes the activities and accomplishments of EG and G Energy Measurements, Inc. (EG and G/EM) from January 1994 through December 1994 for six program areas within the Terrestrial Ecosystem component of the environmental program for the Yucca Mountain Site Characterization Project (YMP): Site Characterization Effects, Desert Tortoises (Gopherus agassizii), Habitat Reclamation, Monitoring and Mitigation, Radiological Monitoring, and Biological Support.

NONE

1995-07-01T23:59:59.000Z

171

New Platforms for Chemical, Biological and Radiation Sensing based on Emerging Micro and Nanostructured Optical Fibres  

Science Journals Connector (OSTI)

Emerging optical materials and structures are driving the development of new optical fibre sensors, with applications ranging from new radiation dosimeters to in-vivo biosensors....

Monro, Tanya M

172

Designing Biological Systems for Sustainability and Programmed Environmental Interface (2011 JGI User Meeting)  

ScienceCinema (OSTI)

The U.S. Department of Energy Joint Genome Institute (JGI) invited scientists interested in the application of genomics to bioenergy and environmental issues, as well as all current and prospective users and collaborators, to attend the annual DOE JGI Genomics of Energy & Environment Meeting held March 22-24, 2011 in Walnut Creek, Calif. The emphasis of this meeting was on the genomics of renewable energy strategies, carbon cycling, environmental gene discovery, and engineering of fuel-producing organisms. The meeting features presentations by leading scientists advancing these topics. Pam Silver of Harvard University gives a presentation on "Designing Biological Systems for Sustainability and Programmed Environmental Interface" at the 6th annual Genomics of Energy & Environment Meeting on March 23, 2011

Silver, Pam [Harvard University

2011-06-03T23:59:59.000Z

173

First annual report on the Biological Monitoring and Abatement Program at Oak Ridge National Laboratory  

SciTech Connect (OSTI)

As a condition of the National Pollutant Discharge Elimination System (NPDES) permit issued to Oak Ridge National Laboratory (ORNL) on April 1, 1986, a Biological Monitoring and Abatement Program (BMAP) was developed for White Oak Creek (WOC); selected tributaries of WOC, including Fifth Creek, First Creek, Melton Branch, and Northwest Tributary; and the Clinch River. BMAP consists of seven major tasks that address both radiological and nonradiological contaminants in the aquatic and terrestrial environs on-site and the aquatic environs off-site. These tasks are (1) toxicity monitoring; (2) bioaccumulation monitoring of nonradiological contaminants in aquatic biota; (3) biological indicator studies; (4) instream ecological monitoring; (5) assessment of contaminants in the terrestrial environment; (6) radioecology of WOC and White Oak Lake (WOL); and (7) contaminant transport, distribution, and fate in the WOC embayment-Clinch River-Watts Bar Reservoir system. This document, the first of a series of annual reports presenting the results of BMAP, describes studies that were conducted from March through December 1986.

Loar, J.M. (ed.); Adams, S.M.; Blaylock, B.G.; Boston, H.L.; Frank, M.L.; Garten, C.T.; Houston, M.A.; Kimmel, B.L.; Ryon, M.G.; Smith, J.G.; Southworth, G.R.; Stewart, A.J.; Walton, B.T.; Berry, J.B.; Talmage, S.S. (Oak Ridge National Lab., TN (United States)); Amano, H. (JAERI, Tokai Res., Establishment, Ibari-Ken (Japan)); Jimenez, B.D. (School of Pharmacy, Univ. of Puerto Rico (San Juan)); Kitchings, J.T.

1992-08-01T23:59:59.000Z

174

Estimation of the biological dose received by five victims of a radiation accident using three different cytogenetic tools  

Science Journals Connector (OSTI)

The present study aims to estimate the biological doses received by five victims (A, B, C, D and E) of the Shanxi Taiyuan radiation accident in China of 2008 and to investigate the value of the cytokinesis-block micronuclei (CBMN) and premature chromosome condensation (PCC) assays in the estimation of biological doses received by the victims of a radiation accident. Conventional chromosome aberration analysis and the CBMN assay, as well as a drug-induced PCC assay recently established by our group, were performed on peripheral blood and bone marrow samples from five victims after the accident. The biological doses were estimated by scoring dicentrics plus centric rings, micronuclei and PCC rings. A high doseeffect curve and the nuclear division index (NDI) we previously established were used to estimate the dose received by victim A, the most highly affected victim of the five. The doses for the five victims (A, B, C, D and E) were 12.4, 3.4, 2.5, 2.1 and 2.2Gy, respectively, estimated by scoring dicentrics plus rings in peripheral blood lymphocytes. Similar results were obtained by combining the CBMN and NDI (CBMN+NDI) assays and the PCC assay. The doses estimated by the three methods were in accordance with the clinical symptoms observed. The specific dicentric assay with a low background level may be a better indicator for biological dose evaluation than the CBMN and PCC assays. The high dose curve we established is reliable and could become a suitable supplement to traditional biodosimetry for dose estimation. The CBMN and drug-induced PCC assays are simple, rapid and accurate. The two methods reinforce and verify the results observed with chromosome aberration analysis.

Bo Yao; Yufang Li; Guangxian Liu; Mei Guo; Juan Bai; Qiuhong Man; Lijuan Qiu; Huisheng Ai

2013-01-01T23:59:59.000Z

175

Low Dose Radiation Research Program: A Paracrine Signal Mediates The Cell  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

A Paracrine Signal Mediates The Cell Transformation Response To Low A Paracrine Signal Mediates The Cell Transformation Response To Low Dose Gamma Radiation in JB6 Cells. Authors: Thomas J. Weber,1 Robert W. Siegel,2 Lye M. Markillie,1 William B. Chrisler,1 Xingye C. Lei,3 and Nancy H. Colburn4 Institutions: 1Cell Biology and Biochemistry, Pacific Northwest National Laboratory, Richland, Washington. 2Protein Function, Pacific Northwest National Laboratory, Richland, Washington. 3Statistical and Mathematical Sciences, Pacific Northwest National Laboratory, Richland, Washington. 4Gene Regulation Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Frederick, Maryland. The carcinogenic response to radiation is complex and may involve adaptive cellular responses as well as a bystander effect mediated by paracrine or

176

Y-12 National Security Complex Biological Monitoring and Abatement Program 2007 Calendar Yeare Report  

SciTech Connect (OSTI)

The National Pollutant Discharge Elimination System (NPDES) permit issued for the Oak Ridge Y-12 National Security Complex (Y-12 Complex) which became effective May 1, 2006, continued a requirement for a Biological Monitoring and Abatement Program (BMAP). The BMAP was originally developed in 1985 to demonstrate that the effluent limitations established for the Y-12 Complex protected the classified uses of the receiving stream (East Fork Poplar Creek: EFPC), in particular, the growth and propagation of aquatic life (Loar et al. 1989). The objectives of the current BMAP are similar, specifically to assess stream ecological conditions relative to regulatory limits and criteria, to assess ecological impacts as well as recovery in response to Y-12 operations, and to investigate the causes of continuing impacts. The BMAP consists of three tasks that reflect complementary approaches to evaluating the effects of the Y-12 Complex discharges on the biotic integrity of EFPC. These tasks include: (1) bioaccumulation monitoring, (2) benthic macroinvertebrate community monitoring, and (3) fish community monitoring. As required by the NPDES permit, the BMAP benthic macroinvertebrate community monitoring task includes studies to annually evaluate the receiving stream's biological integrity in comparison to TN Water Quality Criteria. BMAP monitoring is currently being conducted at five primary EFPC sites, although sites may be excluded or added depending upon the specific objectives of the various tasks. Criteria used in selecting the sites include: (1) location of sampling sites used in other studies, (2) known or suspected sources of downstream impacts, (3) proximity to U.S. Department of Energy (DOE) Oak Ridge Reservation (ORR) boundaries, (4) appropriate habitat distribution, and (5) access. The primary sampling sites include upper EFPC at kilometers (EFKs) 24.4 and 23.4 [upstream and downstream of Lake Reality (LR) respectively]; EFK 18.7 (also EFK 18.2 and 19), located off the ORR and below an area of intensive commercial and light industrial development; EFK 13.8, located upstream from the Oak Ridge Wastewater Treatment Facility (ORWTF); and EFK 6.3 located approximately 1.4 km below the ORR boundary (Fig. 1.1). Actual sampling locations on EFPC may differ slightly by task according to specific requirements of the task. Brushy Fork (BF) at kilometer (BFK) 7.6 and Hinds Creek at kilometer (HCK) 20.6 are the most commonly used reference sites for the Y-12 BMAP. Additional sites off the ORR are also occasionally used for reference, including Beaver Creek, Bull Run, Cox Creek, and Paint Rock Creek (Fig. 1.2). Summaries of the sampling designs for the three primary tasks of the Y-12 Complex BMAP for EFPC are presented in Tables 1.1-1.3. This report covers the 2007 study period, although data collected outside this time period are included as appropriate. To address the biological monitoring requirements for Bear Creek and McCoy Branch, CERCLA-funded data is summarized in Appendix A (for Bear Creek) and Appendix B (for McCoy Branch). Data for these two watersheds is provided herein to address Section IX of the NPDES Permit for Y-12, where 'Results of these CERCLA programs can be used to meet the biological monitoring requirements of this permit'. For potential comparison with instream biological measures, a summary of the toxicity testing results for Y-12 outfalls into upper EFPC is provided in Appendix C (these results have been previously reported).

Peterson, M.J.; Greeley, M. S. Jr.; Morris, G. W.; Roy, W. K.; Ryan, M. G.; Smith, J. G.; Southworth, G. R.

2008-07-01T23:59:59.000Z

177

Structural Biology | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

Structural Biology Structural Biology Biological and Environmental Research (BER) BER Home About Research Research Abstracts Searchable Archive of BER Highlights External link Biological Systems Science Division (BSSD) Genomic Science DOE Bioenergy Research Centers Radiochemistry & Imaging Instrumentation Radiobiology: Low Dose Radiation Research DOE Human Subjects Protection Program Structural Biology DOE Joint Genome Institute Climate and Environmental Sciences Division (CESD) Facilities Science Highlights Benefits of BER Funding Opportunities Biological & Environmental Research Advisory Committee (BERAC) News & Resources Contact Information Biological and Environmental Research U.S. Department of Energy SC-23/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3251 F: (301)

178

Biological Basis for Radiation Adaptive Responses that Protect Against Bronchial Epithelial Cell Transformation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Basis for Radiation Adaptive Responses that Protect Against Bronchial Basis for Radiation Adaptive Responses that Protect Against Bronchial Epithelial Cell Transformation Wenshu Chen, Xiuling Xu, Lang Bai, Mabel T. Padilla, Carmen Tellez, Katherine M. Gott, Shuguang Leng, Julie A. Wilder, Steven A. Belinsky, Bobby R. Scott and Yong Lin, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108 The major hypothesis in this project is that low-dose, low linear-energy-transfer (LET) radiation stimulates an adaptive response that protects cells from neoplastic transformation involving modulation of paracrine factors (e.g., cytokines), cell survival/death signaling pathways, and reprogramming of the epigenome. To test this hypothesis, a validated, sensitive in vitro transformation model and a media transfer

179

Management and Administration of Radiation Protection Programs Guide for Use with Title 10, Code of Federal Regulations, Part 835, Occupational Radiation Protection  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

This Guide discusses acceptable methods for ensuring that radiological activities will be managed and administered in accordance with a documented radiation protection program (RPP) that complies with U.S. Department of Energy (DOE) requirements specified in Title 10 of the Code of Federal Regulations (CFR), Part 835, Occupational Radiation Protection (DOE 1998a), hereinafter referred to as 10 CFR 835. Canceled by DOE G 441.1-1A.

1999-03-17T23:59:59.000Z

180

Mapping of orthologous genes in the context of biological pathways: An application of integer programming  

Science Journals Connector (OSTI)

...30602; and Computational Biology Institute, Oak Ridge National Laboratory, Oak Ridge, TN 37831 Mapping biological pathways across...g., clustalw and paml ). Koonin and co-workers (6) developed a popular method for orthologous...

Fenglou Mao; Zhengchang Su; Victor Olman; Phuongan Dam; Zhijie Liu; Ying Xu

2006-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Radiation dose reduction and image enhancement in biological imaging through equally-sloped tomography  

E-Print Network [OSTI]

Iterative reconstruction algorithm Radiation dose reduction Image enhancement Computed tomography a b s t r-dose data acquisi- tion schemes have made it possible to record multiple projections quickly without-energy electrons (Henderson, 1995), which limits the number of projections that can be acquired. Furthermore

Miao, Jianwei "John"

182

Biological effects of radiation from dental radiography. Council on Dental Materials, Instruments, and Equipment  

SciTech Connect (OSTI)

Clearly, there is ample evidence of adverse effects of radiation in sufficient doses. There is at present no proof of such effects from doses commonly employed in dental practice; however, it has not been possible to prove the absence of such effects. Most experts now agree that there may be a small, difficult to quantify risk of cancer or genetic mutation from diagnostic exposure in patients and in personnel exposed during work. Prudence dictates acceptance of this position until proof to the contrary is available. This report has presented recent attempts to quantify the risk to patients based on speculative calculations and extrapolations. Indices of population risks indicate that medical radiology is the largest source of human-made genetic and leukemogenic radiation burden to the American public. Dental radiology contributes a small-but not necessarily insignificant-portion. Of major concern is the increasing use of radiation for diagnostic purposes in both medicine and dentistry. Technological advances have reduced exposure per examination; presumably this trend will continue so that total exposure of populations to radiation in the healing arts will not increase. Recent analyses suggest that the cancer risk to a patient from a dental radiographic examination is of the order of one in a million; the genetic risk is substantially less, about one in a billion. The risks appear to be essentially equal for full-mouth intraoral and for panoramic examinations. These estimates are numerically quite small, but the effects are severe. Thus, these risks cannot be ignored. However, we currently accept risks of similar magnitude in our daily lives (Table 9)50,51 In addition, the risk of failure to make an accurate diagnosis may be greater than the risk from exposure to the radiation from a justified and properly conducted radiographic examination.

Gibbs, S.J.

1982-08-01T23:59:59.000Z

183

Occupational ALARA Program Guide for Use with Title 10, CFR, Part 835, Occupational Radiation Protection  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

This Guide provides an acceptable methodology for establishing and operating an occupational "as low as is reasonably achievable" (ALARA) program that will comply with U.S. Department of Energy (DOE) requirements specified in Title 10 of the Code of Federal Regulations (CFR), Part 835, Occupational Radiation Protection (DOE 1998a), hereinafter referred to as 10 CFR 835. For completeness, this Guide also references detailed guidance provided in the DOE-STD-1098-99, RADIOLOGICAL CONTROL (DOE 1999a), hereinafter referred to as the RCS.

1999-03-17T23:59:59.000Z

184

Evaluation of the Multi-scale Modeling Framework Using Data from the Atmospheric Radiation Measurement Program  

SciTech Connect (OSTI)

One of the goals of the Atmospheric Radiation Measurement (ARM) program is to provide long-term observations for evaluating and improving cloud and radiation treatment in global climate models. Unfortunately, the traditional parametric approach of diagnosing cloud and radiation properties for gridcells that are tens to hundreds kilometers across from large-scale model fields is not well suited for comparison with time series of ground based observations at selected locations. A recently emerging approach called a multi-scale modeling framework (MMF) has shown promise to bridge the scale gap. The MMF consists of a two-dimensional or small three-dimensional cloud resolving model (CRM) embedded into each grid column of the Community Atmospheric Model (CAM), thereby computing cloud properties at a scale that is more consistent with observations. We present a comparison of data from two ARM sites, one at the Southern Great Plains (SGP) in Oklahoma and one at Nauru Island in the Tropical Western Pacific (TWP) region, with output from both the CAM and MMF. Two sets of one year long simulations are considered: one using climatological sea surface temperatures (SST) and another using 1999 SST. Each set includes a run with the MMF as well as the CAM run with traditional or standard cloud and radiation treatment. Time series of cloud fraction, precipitation intensity, and downwelling solar radiation flux at the surface are statistically analyzed. For the TWP site, nearly all parameters of frequency distributions of these variables from the MMF run are shown to be more consistent with observation than those from the CAM run. This change is attributed to the improved representation of convective clouds in the MMF compared to the conventional climate model. For the SGP, the MMF shows little to no improvement in predicting the same quantities. Possible causes of this lack of improvement are discussed.

Ovtchinnikov, Mikhail; Ackerman, Thomas P.; Marchand, Roger T.; Khairoutdinov, Marat

2006-05-01T23:59:59.000Z

185

Evaluation of the Multi-Scale Modeling Framework using Data from the Atmospheric Radiation Measurement Program  

SciTech Connect (OSTI)

One of the goals of the Atmospheric Radiation Measurement (ARM) program was to provide long-term observations for evaluation of cloud and radiation treatment in global climate models. Unfortunately, traditional parametric approach of diagnosing cloud and radiation properties from large-scale model fields is not well suited for comparison with observed time series at selected locations. A recently emerging approach called the multi-scale modeling framework (MMF) has shown promise to bridge the gap. MMF consists of a two-dimensional cloud system resolving model (CSRM) embedded into each CAM grid column of the Community Atmospheric Model (CAM), thereby computing cloud properties at a scale that is more consistent with observations. Because the approach is computationally expensive only limited simulations have been carried out. In this presentation, we will present a comparison of data from two ARM sites, one at the Southern Great Plains (SGP) in Oklahoma and one at Nauru island in the Tropical Western Pacific (TWP) region, with output from both CAM and MMF. Two sets of one year long simulations are considered: one using climatological sea surface temperatures (SST) and another using 1999 SST. Each set includes a run with MMF as well as CAM run with traditional or standard cloud and radiation treatment. Time series of cloud fraction, precipitation intensity, and downwelling solar radiation flux at the surface are statistically analyzed. For the TWP site, nearly all parameters of frequency distributions of these variables from MMF run are shown to be more consistent with observation than those from CAM run. For the SGP, the improvements are marginal.

Ovchinnikov, Mikhail; Ackerman, Thomas P.; Marchand, Roger T.; Khairoutdinov, Marat

2004-07-01T23:59:59.000Z

186

Community Radiation Monitoring Program. Annual report, October 1, 1991--September 30, 1992  

SciTech Connect (OSTI)

The Community Radiation Monitoring Program (CRMP) is a cooperative effort between the US Department of Energy (DOE); the US Environmental Protection Agency (EPA); the Desert Research Institute (DRI), a division of the University and Community College System of Nevada and the Nuclear Engineering Laboratory of the University of Utah (UNEL). The twelfth year of the program began in the fall of 1991, and the work continues as an integral part of the DOE-sponsored long-term offsite radiological monitoring effort that has been conducted by EPA and its predecessors since the inception of nuclear testing at the Nevada Test Site (NTS). The program began as an outgrowth of activities that occurred during the Three Mile Island incident in 1979. The local interest and public participation that took place there were thought to be transferrable to the situation at the NTS, so, with adaptations, that methodology was implemented for this program. The CRMP began by enhancing and centralizing environmental monitoring and sampling equipment at 15 communities in the existing EPA monitoring network, and has since expanded to 19 locations in Nevada, Utah and California. The primary objectives of this program are still to increase the understanding by the people who live in the area surrounding the NTS of the activities for which DOE is responsible, to enhance the performance of radiological sampling and monitoring, and to inform all concerned of the results of these efforts. One of the primary methods used to improve the communication link with people in the potentially impacted area has been the hiring and training of local citizens as station managers and program representatives in those selected communities in the offsite area. These managers, active science teachers wherever possible, have succeeded, through their training, experience, community standing, and effort, in becoming a very visible, able and valuable asset in this link.

Cooper, E.N.

1993-05-01T23:59:59.000Z

187

DNA Radiation Environments Program Spring 1991 2-meter box experiments and analyses. [DEfense Nuclear Agency (DNA)  

SciTech Connect (OSTI)

This report summarizes the Spring 1991 2-m Box experiments that were performed at the Army Pulse Radiation Facility (APRF) at Aberdeen Proving Ground. These studies were sponsored by the Defense Nuclear Agency (DNA) under the Radiation Environments Program to obtain measured data for benchmarking the Adjoint Monte Carlo Code System, MASH, Version 1.0. The MASH code system was developed for the Department of Defense and NATO for calculating neutron and gamma-ray radiation fields and shielding protection factors for armored vehicles and military structures against nuclear weapon radiation. In the 2-m Box experiments, neutron and gamma-ray dose rates and reduction factors were measured in the free-field and as a function of position on an anthropomorphic phantom that was placed outside and inside a borated polyethylene lined steel-walled 2-m box. The data were acquired at a distance of 400-m from the APRF reactor. The purpose of these experiments was to measure the neutron and gamma-ray dose rates as a function of detector location on the phantom for cases when the phantom was in the free-field and inside of the box. Neutron measurements were made using a BD-100R bubble detector and gamma-ray measurements were made using thermoluminescent detectors (TLD). Calculated and measured data were compared in terms of the C/M ratio. The calculated and measured neutron and gamma-ray dose rates and reduction factors agreed on the average within the [plus minus]20% limits mandated by DNA and demonstrate the capability of the MASH code system in reproducing measured data in nominally shielded assemblies.

Santoro, R.T. (Oak Ridge National Lab., TN (United States)); Whitaker, S.Y. (Clark Atlanta Univ., GA (United States))

1993-03-01T23:59:59.000Z

188

Results from two workshops: Developing and amending regulations and funding state radiation control programs  

SciTech Connect (OSTI)

The first section of this document presents the results of a technical workshop on the process of regulations development and amendment sponsored by the Nuclear Regulatory Commission (NRC). This workshop focused on methods for reducing the time it takes to promulgate regulations to help those States that are having difficulty meeting the three-year deadline for adopting new NRC regulations. Workshop participants responded to six questions, reviewed the procedures used by various States for revising and adopting changes to their regulations, and reviewed the time-flow charts used by various States. This workshop was designed to provide guidance to States that are promulgating and revising regulations. The second section of this document summarizes the proceedings of a technical workshop, also sponsored by the NRC, on funding radiation control programs that emphasized fee schedules and effective strategies for the 1990s. This workshop focused on determining the true costs of running a program, on setting realistic fees for the various categories of licenses, and on the most efficient methods for sending invoices, recording receipts, depositing money received, and issuing licenses. Workshop participants responded to seven questions; reviewed the methods various States use to determine true costs; reviewed the procedure that the various States use to produce invoices and licenses; reviewed the procedures that the States are required to abide by when they receive money; and reviewed the method used by the NRC to determine the cost of its various programs.

Parker, G.

1993-09-01T23:59:59.000Z

189

Low Dose Radiation Research Program: A Variable Energy Soft X-ray  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Variable Energy Soft X-ray Microprobe to Investigate Mechanisms of Variable Energy Soft X-ray Microprobe to Investigate Mechanisms of the Radiation Induced Bystander Effect. Authors: Melvyn Folkard, Borivoj Vojnovic, Giuseppe Schettino, Kevin M Prise and Barry D Michael. Institutions: Gray Cancer Institute. We are currently engaged on two projects in the Low-dose Program: "Low dose studies with focused X-rays in cell and tissue models: mechanisms of bystander and genomic instability responses" (DE-FG07-99ER62877) and "Mechanistic modeling of bystander effects: An integrated theoretical and experimental approach" (DE-FG02-02ER63305). Central to both of these studies is a unique micro irradiation facility that uses ultrasoft X-rays focused to a sub micron beam for individual cell and sub cellular targeting. This facility allows us to selectively irradiate individual

190

Low Dose Radiation | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

Radiobiology: Low Dose Radiation Radiobiology: Low Dose Radiation Research Biological and Environmental Research (BER) BER Home About Research Research Abstracts Searchable Archive of BER Highlights External link Biological Systems Science Division (BSSD) Genomic Science DOE Bioenergy Research Centers Radiochemistry & Imaging Instrumentation Radiobiology: Low Dose Radiation Research DOE Human Subjects Protection Program Structural Biology DOE Joint Genome Institute Climate and Environmental Sciences Division (CESD) Facilities Science Highlights Benefits of BER Funding Opportunities Biological & Environmental Research Advisory Committee (BERAC) News & Resources Contact Information Biological and Environmental Research U.S. Department of Energy SC-23/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3251 F: (301)

191

HARVARD UNIVERSITY CHEMICAL BIOLOGY  

E-Print Network [OSTI]

HARVARD UNIVERSITY CHEMICAL BIOLOGY PHD PROGRAM 2013-2014 Student Handbook #12;Program Contacts at the beginning of each semester. Laboratory Rotations Students in the Chemical Biology Program are expected an interest in having Chemical Biology Program Students in their labs. Students may rotate in the labs

Church, George M.

192

Biological monitoring and abatement program plan for Oak Ridge National Laboratory  

SciTech Connect (OSTI)

The overall purpose of this plan is to evaluate the receiving streams` biological communities for the duration of the permit and meet the objectives for the ORNL BMAP as outlined in the NPDES permit (Appendix). The ORNL BMAP will focus on those streams in the WOC watershed that (1) receive NPDES discharges and (2) have been identified as ecologically impacted. In response to the newly issued NPDES permit, the tasks that are included in this BMAP plan include monitoring biological communities (fish and benthic invertebrates), monitoring mercury contamination in fish and water, monitoring polychlorinated biphenyl (PCB) contamination in fish, and evaluating temperature loading from ORNL outfalls. The ORNL BMAP will evaluate the effects of sediment and oil and grease, as well as the chlorine control strategy through the use of biological community data. Monitoring will be conducted at sites in WOC, First Creek, Fifth Creek, Melton Branch, and WOL.

Kszos, L.A.; Anderson, G.E.; Gregory, S.M.; Peterson, M.J.; Ryon, M.G.; Schilling, E.M.; Smith, J.G.; Southworth, G.R. [Oak Ridge National Lab., TN (United States); Phipps, T.L. [CKY, Inc., Oak Ridge, TN (United States)

1997-06-01T23:59:59.000Z

193

Office of Biological and Environmental Research  

E-Print Network [OSTI]

The Underlying Assumption for (Low Dose) Dosimetry: "If the spatial and temporal distribution of energy Program U.S. Department of Energy Radiation Dosimetry Standardization Workshop NCI / NIAID / NIST September 15 -16, 2011 #12;U.S. Department of Energy · Office of Science · Biological and Environmental

194

Third report on the Oak Ridge K-25 Site Biological Monitoring and Abatement Program for Mitchell Branch  

SciTech Connect (OSTI)

As a condition of the modified National Pollutant Discharge Elimination System (NPDES) permit issued to the Oak Ridge Gaseous Diffusion Plant (ORGDP; now referred to as the Oak Ridge K-25 Site) on September 11, 1986, a Biological Monitoring and Abatement Program (BMAP) was developed for the receiving stream (Mitchell Branch or K-1700 stream). On October 1, 1992, a renewed NPDES permit was issued for the K-25 Site. A biological monitoring plan was submitted for Mitchell Branch, Poplar Creek, Poplar Creek Embayment of the Clinch River and any unnamed tributaries of these streams. The objectives of BMAP are to (1) demonstrate that the effluent limitations established for the Oak Ridge K-25 Site protect and maintain the use of Mitchell Branch for growth and propagation of fish and other aquatic life and (2) document the effects on stream biota resulting from operation of major new pollution abatement facilities, including the Central Neutralization Facility (CNF) and the Toxic Substances Control Act (TSCA) incinerator. The BMAP consists of four tasks: (1) toxicity monitoring; (2) bioaccumulation monitoring; (3) assessment of fish health; and (4) instream monitoring of biological communities, including benthic macroinvertebrates and fish. This document, the third in a series, reports on the results of the Oak Ridge K-25 Site BMAP; it describes studies that were conducted over various periods of time between June 1990 and December 1993, although monitoring conducted outside this time period is included, as appropriate.

Hinzman, R.L. [ed.; Adams, S.M.; Ashwood, T.L. [Oak Ridge National Lab., TN (United States)] [and others

1995-08-01T23:59:59.000Z

195

Second report on the Oak Ridge Y-12 Plant Biological Monitoring and Abatement Program for East Fork Poplar Creek  

SciTech Connect (OSTI)

As stipulated in the National Pollutant Discharge Elimination System (NDPES) permit issued to the Oak Ridge Y-12 Plant on May 24, 1986, a Biological Monitoring and Abatement Program (BMAP) was developed for the receiving stream, East Fork Poplar Creek (EFPC). The objectives of BMAP are (1) to demonstrate that the current effluent limitations established for the Y-12 Plant protect the classified uses of EFPC (e.g., the growth and propagation of fish and aquatic life), as designated by the Tennessee Department of Environment and Conservation (TDEC) and (2) to document the ecological effects resulting from implementation of a Water Pollution Control Program that includes construction of several large wastewater treatment facilities. BMAP consists of four major tasks: (1) ambient toxicity testing; (2) bioaccumulation studies; (3) biological indicator studies; and (4) ecological surveys of stream communities, including periphyton (attached algae), benthic (bottom-dwelling) macroinvertebrates, and fish. This document, the second in a series of reports on the results of the Y-12 Plant BMAP, describes studies that were conducted between July 1986 and July 1988, although additional data collected outside this time period are included, as appropriate.

Hinzman, R.L. [ed.; Adams, S.M. [Oak Ridge National Lab., TN (United States); Black, M.C. [Oklahoma State Univ., Stillwater, OK (United States)] [and others

1993-06-01T23:59:59.000Z

196

First report on the Oak Ridge Y-12 Plant Biological Monitoring and Abatement Program for East Fork Poplar Creek  

SciTech Connect (OSTI)

As stipulated in the National Pollutant Discharge Elimination System (NPDES) permit issued to the Oak Ridge Y-12 Plant on May 24, 1985, a Biological Monitoring and Abatement Program (BMAP) was developed for the receiving stream, East Fork Poplar Creek (EFPC). The objectives of the BMAP are (1) to demonstrate that the current effluent limitations established for the Oak Ridge Y-12 Plant protect the uses of EFPC (e.g., the growth and propagation of fish and aquatic life), as designated by the Tennessee Department of Environment and Conservation (TDEC) [formerly the Tennessee Department of Health and Environment (TDHE)], and (2) to document the ecological effects resulting from implementation of a water pollution control program that includes construction of several large wastewater treatment facilities. The BMAP consists of four major tasks: (1) ambient toxicity testing, (2) bioaccumulation studies, (3) biological indicator studies, and (4) ecological surveys of stream communities, including periphyton (attached algae), benthic macroinvertebrates, and fish. This document, the first in a series of reports on the results of the Y-12 Plant BMAP, describes studies that were conducted from May 1985 through September 1986.

Loar, J.M.; Adams, S.M.; Allison, L.J.; Boston, H.L.; Huston, M.A.; McCarthy, J.F.; Smith, J.G.; Southworth, G.R.; Stewart, A.J. (Oak Ridge National Lab., TN (United States)); Black, M.C. (Oklahoma State Univ., Stillwater, OK (United States)); Gatz, A.J. Jr. (Ohio Wesleyan Univ., Delaware, OH (United States)); Hinzman, R.L. (Oak Ridge Research Inst., TN (United States)); Jimenez, B.D. (Puerto Rico Univ.,

1992-07-01T23:59:59.000Z

197

Assistant Professor Biomedical Communications The Biomedical Communications program, within the Department of Biology University of Toronto  

E-Print Network [OSTI]

Assistant Professor ­ Biomedical Communications The Biomedical Communications program, within-stream faculty appointment in Biomedical Communications at the rank of Assistant Professor, effective July 1 visualization, biomedical communications, medical illustration, instructional media design and/or educational

Sokolowski, Marla

198

Appendix G. Radiation Appendix G. Radiation  

E-Print Network [OSTI]

-made sources. People are exposed to naturally occurring radiation constantly. For example, cosmic radiation of radiation and its effects on the environment and biological systems. Radiation comes from natural and humanAppendix G. Radiation #12;#12;Appendix G. Radiation This appendix presents basic facts about

Pennycook, Steve

199

Biological Safety  

Broader source: Energy.gov [DOE]

The DOE's Biological Safety Program provides a forum for the exchange of best practices, lessons learned, and guidance in the area of biological safety. This content is supported by the Biosurety Executive Team. The Biosurety Executive Team is a DOE-chartered group. The DOE Office of Worker Safety and Health Policy provides administrative support for this group. The group identifies biological safety-related issues of concern to the DOE and pursues solutions to issues identified.

200

Steel Creek primary producers: Periphyton and seston, L-Lake/Steel Creek Biological Monitoring Program, January 1986--December 1991  

SciTech Connect (OSTI)

The Savannah River Site (SRS) encompasses 300 sq mi of the Atlantic Coastal Plain in west-central South Carolina. Five major tributaries of the Savannah River -- Upper Three Runs Creek, Four Mile Creek, Pen Branch, Steel Creek, and Lower Three Runs Creek -- drain the site. In 1985, L Lake, a 400-hectare cooling reservoir, was built on the upper reaches of Steel Creek to receive effluent from the restart of L-Reactor and to protect the lower reaches from thermal impacts. The Steel Creek Biological Monitoring Program was designed to assess various components of the system and identify and changes due to the operation of L-Reactor or discharge from L Lake. An intensive ecological assessment program prior to the construction of the lake provided baseline data with which to compare data accumulated after the lake was filled and began discharging into the creek. The Department of Energy must demonstrate that the operation of L-Reactor will not significantly alter the established aquatic ecosystems. This report summarizes the results of six years` data from Steel Creek under the L-Lake/Steel Creek Monitoring Program. L Lake is discussed separately from Steel Creek in Volumes NAI-SR-138 through NAI-SR-143.

Bowers, J.A. [Westinghouse Savannah River Co., Aiken, SC (United States); Toole, M.A.; van Duyn, Y. [Normandeau Associates Inc., New Ellenton, SC (United States)

1992-02-01T23:59:59.000Z

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Radiation Protection Programs Guide for Use with Title 10, Code of Federal Regulations, Part 835, Occupational Radiation Protection  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

Provides guidance for implementing the provisions of the functional areas contained in 10 CFR 835. The revision to the guide reflects changes in the June 2007 amendment to 10 CFR 835, Worker Safety and Health Program. Cancels DOE G 441.1-1B. Admin Chg 1 dated 7-8-11.

2008-05-19T23:59:59.000Z

202

Radiation Protection Programs Guide for Use with Title 10, Code of Federal Regulations, Part 835, Occupational Radiation Protection  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

Provides guidance for implementing the provisions of the functional areas contained in 10 CFR 835. The revision to the guide reflects changes in the June 2007 amendment to 10 CFR 835, Worker Safety and Health Program. Cancels DOE G 441.1-1B. Admin Chg 1, dated 7-8-11, cancels DOE G 441.1-1C.

2008-05-19T23:59:59.000Z

203

Review of the Occupational Radiation Protection Program as Implemented and Recently Enhanced at the Idaho National Laboratory, September 2011  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Review of the Review of the Occupational Radiation Protection Program as Implemented and Recently Enhanced at the Idaho National Laboratory May 2011 September 2011 Office of Safety and Emergency Management Evaluations Office of Health, Safety and Security U.S. Department of Energy Table of Contents 1.0 Purpose ........................................................................................................................1 2.0 Background .................................................................................................................1 3.0 Scope ...........................................................................................................................2 4.0 Results .........................................................................................................................2

204

Low Dose Radiation Research Program: Impact of Genetic Factors on the  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Genetic Factors on the Heritable Effects of Paternal Exposure to Genetic Factors on the Heritable Effects of Paternal Exposure to Low-Dose Radiation Janet E. Baulch University of California, Davis Why This Project? There is concern about the possible genetic effects of low dose radiation exposure. As a result, much effort has gone towards understanding mutation of cells due to radiation exposure. While recognition of the potential for mutation from exposure to ionizing radiation has led to extensive research, less effort has been given to the possible delayed risk of radiation exposure transmitted to the offspring of the exposed parent. Data from animal models show that parental exposures to DNA-damaging agents, such as ionizing radiation, predispose the offspring to serious health effects, including cancer offspring. Additionally, data from both humans and animal

205

Space radiation shielding analysis and dosimetry for the space shuttle program  

Science Journals Connector (OSTI)

Active and passive radiation dosimeters have been flown on every Space Shuttle mission to measure the naturally?occurring background Van Allen and galactic cosmic radiation doses that astronauts and radiation?sensitive experiments and payloads receive. A review of the various models utilized at the NASA/Johnson Space Center Radiation Analysis and Dosimetry is presented. An analytical shielding model of the Shuttle was developed as an engineering tool to aid in making premission radiation dose calculations and is discussed in detail. The anatomical man models are also discussed. A comparison between the onboard dosimeter measurements for the 24 Shuttle missions to date and the dose calculations using the radiation environment and shielding models is presented.

William Atwell; E. R. Beever; A. C. Hardy; R. G. Richmond; B. L. Cash

1989-01-01T23:59:59.000Z

206

Biological effectiveness of neutrons: Research needs  

SciTech Connect (OSTI)

The goal of this report was to provide a conceptual plan for a research program that would provide a basis for determining more precisely the biological effectiveness of neutron radiation with emphasis on endpoints relevant to the protection of human health. This report presents the findings of the experts for seven particular categories of scientific information on neutron biological effectiveness. Chapter 2 examines the radiobiological mechanisms underlying the assumptions used to estimate human risk from neutrons and other radiations. Chapter 3 discusses the qualitative and quantitative models used to organize and evaluate experimental observations and to provide extrapolations where direct observations cannot be made. Chapter 4 discusses the physical principles governing the interaction of radiation with biological systems and the importance of accurate dosimetry in evaluating radiation risk and reducing the uncertainty in the biological data. Chapter 5 deals with the chemical and molecular changes underlying cellular responses and the LET dependence of these changes. Chapter 6, in turn, discusses those cellular and genetic changes which lead to mutation or neoplastic transformation. Chapters 7 and 8 examine deterministic and stochastic effects, respectively, and the data required for the prediction of such effects at different organizational levels and for the extrapolation from experimental results in animals to risks for man. Gaps and uncertainties in this data are examined relative to data required for establishing radiation protection standards for neutrons and procedures for the effective and safe use of neutron and other high-LET radiation therapy.

Casarett, G.W.; Braby, L.A.; Broerse, J.J.; Elkind, M.M.; Goodhead, D.T.; Oleinick, N.L.

1994-02-01T23:59:59.000Z

207

Characterisation of radiation field for irradiation of biological samples at nuclear reactorcomparison of twin detector and recombination methods  

Science Journals Connector (OSTI)

......Symposium on Neutron and Ion Dosimetry...radiation and thermal neutrons, has been...overexposure to fission neutrons...on their energy spectrum. So, there...well as its neutron and gamma...radiation-induced damage to...thermalised fission neutrons...the neutron energy does not...activated by thermal neutrons......

N. Golnik; M. A. Gryzi?ski; M. Kowalska; K. Meronka; P. Tulik

2014-10-01T23:59:59.000Z

208

Low Dose Radiation Research Program: A Variable Energy Soft X-ray  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Variable Energy Soft X-ray Microprobe to Investigate Mechanisms of the Variable Energy Soft X-ray Microprobe to Investigate Mechanisms of the Radiation-Induced Bystander Effect Melvyn Folkard Gray Cancer Institute Why This Project The aim of this project is to determine the effects of low radiation doses using a machine that makes it possible to radiate one cell at a time. Our soft X-ray microprobe can irradiate individual cells, or locations within cells with defined doses and with sub-micron precision. We can use low doses approaching that of a single electron track, which is of relevance to environmental level exposures. Much of our work is concentrating on irradiating specified individual cells within cell populations to identify "bystander responses" where non-radiated cells respond to signals from nearby radiated cells. Higher energy x-rays are being generated to extend

209

Low Dose Radiation Research Program: Using a Low LET Electron Microbeam to  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

a Low LET Electron Microbeam to Investigate Non-Targeted Effects of a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation William F. Morgan Radiation Oncology Research Laboratory, Pacific Northwest National Laboratory Why this Project? To examine genomic instability and bystander effects as non-targeted effects associated with low dose radiation exposure. Project Goals To provides a robust, reliable, highly sensitive assay for detecting delayed events occurring in cells exposed to low doses of ionizing radiation. Experimental Approach To mimic radiation damage from gamma and x-ray sources, a low-LET electron microbeam that generates energetic electrons has been designed such that high-energy electrons deposit energy in a pre-selected subset of cells leaving neighboring cells unirradiated. Using a novel green fluorescence gene (GFP) reporter assay, a high through

210

ENGINEERING GRaduatE PRoGRams Biological SyStemS engineering Biomedical engineering chemical engineering civil and environmental engineering  

E-Print Network [OSTI]

properties and devices, fluid mechanics and rheology, green engineering and design, interfaces, mathematical resources engineering (hydraulics and fluid mechanics, hydrology, and systems planning and designENGINEERING GRaduatE PRoGRams Biological SyStemS engineering § Biomedical engineering § chemical

California at Davis, University of

211

ENGINEERING GRaduatE PRoGRams Biological SyStemS engineering Biomedical engineering chemical engineering civil and environmental engineering  

E-Print Network [OSTI]

modeling, environmental engineering, fluid mechanics and rheology, materials processing, nanotechnology resources engineering (hydraulics and fluid mechanics, hydrology, and systems planning and designENGINEERING GRaduatE PRoGRams Biological SyStemS engineering § Biomedical engineering § chemical

California at Davis, University of

212

Hypothesis regarding a membrane-associated mechanism of biological action due to low-dose ionizing radiation  

Science Journals Connector (OSTI)

A novel theory is proposed regarding the action of ionizing radiation in the range of very low doses. The basic premise of the theory presented is that the low-dose effect cannot be explained by direct damage ......

Lazar Kh. Eidus

2000-09-01T23:59:59.000Z

213

Low Dose Radiation Research Program: Dual Regulation of JB6 Transformation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Dual Regulation of JB6 Transformation by Low Dose Gamma Radiation. Dual Regulation of JB6 Transformation by Low Dose Gamma Radiation. Authors: Thomas J. Weber,1 Lye M. Markillie,1 William B. Chrisler,1 Xingye C. Lei,1 and Nancy H. Colburn2 Institutions: 1Molecular Biosciences, Pacific Northwest National Laboratory. 2Gene Regulation Section, Basic Research Laboratory, National Cancer Institute JB6 mouse epidermal cells have been instrumental in defining the molecular mechanisms associated with neoplastic transformation in response to known tumor promoters. JB6 cells exhibit a clonal growth response to oxygen free radicals suggesting this model may also be useful for radiation research. Treatment of JB6 cells with 2 and 20 cGy gamma radiation resulted in a weak, but dose-dependent increase in anchorage-independent growth observed

214

Low Dose Radiation Research Program: Using a Low LET Electron Microbeam to  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Using a Low LET Electron Microbeam to Investigate Non-Targeted Using a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation Authors: William F. Morgan1 and Marianne B. Sowa2 Institutions: 1Radiation Oncology Research Laboratory, University of Maryland, Baltimore, Maryland; 2Chemical Structure and Dynamics, Pacific Northwest National Laboratory, Richland Washington We have recently installed a low-linear energy transfer (LET) electron microbeam that generates energetic electrons to mimic radiation damage from gamma- and x-ray sources. It has been designed such that high-energy electrons deposit energy in a pre-selected subset of cells, leaving neighboring cells unirradiated (Figure 1). In this way it is possible to examine non-targeted effects associated with low dose radiation exposure,

215

Fourth report on the Oak Ridge National Laboratory Biological Monitoring and Abatement Program for White Oak Creek Watershed and the Clinch River  

SciTech Connect (OSTI)

In response to a condition of the National Pollutant Discharge Elimination System (NPDES) permit issued to Oak Ridge National Laboratory (ORNL) on April 1, 1986, a Biological Monitoring and Abatement Program (BMAP) was developed for White Oak Creek (WOC) and selected tributaries. BMAP currently consists of six major tasks that address both radiological and nonradiological contaminants in the aquatic and terrestrial environs on-site and the aquatic environs off-site. These tasks are (1) toxicity monitoring, (2) bioaccumulation monitoring of nonradiological contaminants in aquatic biota, (3) biological indicator studies, (4) instream ecological monitoring, (5) assessment of contaminants in the terrestrial environment, and (6) radioecology of WOC and White Oak Lake. The ecological characterization of the WOC watershed will provide baseline data that can be used to document the ecological effects of the water pollution control program and the remedial action program. The long-term nature of BMAP ensures that the effectiveness of remedial measures will be properly evaluated.

Loar, J.M. [ed.] [ed.

1994-04-01T23:59:59.000Z

216

Efficacy of an integrated continuing medical education (CME) and quality improvement (QI) program on radiation oncologist (RO) clinical practice  

SciTech Connect (OSTI)

Purpose: There has been little radiation oncologist (RO)-specific research in continuing medical education (CME) or quality improvement (QI) program efficacy. Our aim was to evaluate a CME/QI program for changes in RO behavior, performance, and adherence to department protocols/studies over the first 12 months of the program. Methods and Materials: The CME/QI program combined chart audit with feedback (C-AWF), simulation review AWF (SR-AWF), reminder checklists, and targeted CME tutorials. Between April 2003 and March 2004, management of 75 patients was evaluated by chart audit with feedback (C-AWF) and 178 patients via simulation review audit (SR-AWF) using a validated instrument. Scores were presented, and case management was discussed with individualized educational feedback. RO behavior and performance was compared over the first year of the program. Results: Comparing the first and second 6 months, there was a significant improvement in mean behavior (12.7-13.6 of 14, p = 0.0005) and RO performance (7.6-7.9 of 8, p = 0.018) scores. Protocol/study adherence significantly improved from 90.3% to 96.6% (p = 0.005). A total of 50 actions were generated, including the identification of learning needs to direct CME tutorials, the systematic change of suboptimal RO practice, and the alteration of deficient management of 3% of patients audited during the program. Conclusion: An integrated CME/QI program combining C-AWF, SR-AWF, QI reminders, and targeted CME tutorials effectively improved targeted RO behavior and performance over a 12-month period. There was a corresponding increase in departmental protocol and study adherence.

Leong, Cheng Nang [Department of Radiation Oncology, Cancer Institute, National University Hospital (Singapore) and Department of Radiation Oncology, Cancer Institute, Tan Tock Seng Hospital (Singapore)]. E-mail: Cheng_Nang_Leong@mail.nhg.com.sg; Shakespeare, Thomas Philip [Department of Radiation Oncology, Cancer Institute, National University Hospital (Singapore); North Coast Cancer Institute, Coffs Harbour (Australia); Mukherjee, Rahul K. [Department of Radiation Oncology, Cancer Institute, National University Hospital (Singapore); Department of Radiation Oncology, Cancer Institute, Tan Tock Seng Hospital (Singapore); Back, Michael F. [Department of Radiation Oncology, Cancer Institute, National University Hospital (Singapore); Department of Radiation Oncology, Cancer Institute, Tan Tock Seng Hospital (Singapore); Lee, Khai Mun [Department of Radiation Oncology, Cancer Institute, National University Hospital (Singapore); Department of Radiation Oncology, Cancer Institute, Tan Tock Seng Hospital (Singapore); Lu, Jiade Jay [Department of Radiation Oncology, Cancer Institute, National University Hospital (Singapore); Department of Radiation Oncology, Cancer Institute, Tan Tock Seng Hospital (Singapore); Wynne, Christopher J. [Department of Radiation Oncology, Cancer Institute, National University Hospital (Singapore); Lim, Keith [Department of Radiation Oncology, The Cancer Institute, National University Hospital (Singapore); Tang, Johann [Department of Radiation Oncology, Cancer Institute, National University Hospital (Singapore); Department of Radiation Oncology, Cancer Institute, Tan Tock Seng Hospital (Singapore); Zhang Xiaojian [Department of Radiation Oncology, Cancer Hospital, Fudan Hospital, Shanghai (China)

2006-12-01T23:59:59.000Z

217

DOE Low Dose Radiation Research Workshop I November 1999  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Low Dose Radiation Research Program Low Dose Radiation Research Program U.S. Department of Energy Office of Biological and Environmental Research David G. Thomassen, Ph.D. Program Coordinator Office of Biological and Environmental Research U.S. Department of Energy, SC-72 19901 Germantown Road Germantown, MD 20874-1290 Phone: 301-903-9817 Fax: 301-903-8521 Email: david.thomassen@science.doe.gov Arthur Katz, Ph.D. Life Sciences Division Office of Biological and Environmental Research U.S. Department of Energy, SC-72 19901 Germantown Road Germantown, MD 20874-1290 Phone: 301-903-4932 Fax: 301-903-8521 Email: arthur.katz@science.doe.gov Marvin E. Frazier, Ph.D. Director, Life Sciences Division Office of Biological and Environmental Research U.S. Department of Energy, SC-72 19901 Germantown Road

218

Florida Radiation Protection Act (Florida)  

Broader source: Energy.gov [DOE]

The Department of Public Health is responsible for administering a statewide radiation protection program. The program is designed to permit development and utilization of sources of radiation for...

219

Low Dose Radiation Research Program: DNA Damage in Acutely Irradiated F2  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

DNA Damage in Acutely Irradiated F2 Mice with a History of Paternal DNA Damage in Acutely Irradiated F2 Mice with a History of Paternal F0 Germline Irradiation Authors: J.E. Baulch and O.G. Raabe Institutions: Center for Health and the Environment, University of California, Davis, CA. The main goal of this grant is to evaluate heritable, transgenerational effects of low dose, low-linear-energy-transfer (LET) radiation (0.1 Gy attenuated 137Cs gamma rays) on Type B spermatogonia in 129SVE mice; wild-type and heterozygous for Ataxia-telangiectasia (AT). The ATM heterozygotes are carriers for a genetic mutation (AT mutated, ATM) that is thought to predispose both humans and mice to radiation sensitivity. Experiments conducted in our laboratory have demonstrated heritable effects of paternal germline exposure to ionizing radiation in mice using 1.0 Gy of

220

Low Dose Radiation Research Program: Modeling the Physics of Damage Cluster  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Modeling the Physics of Damage Cluster Formation in a Cellular Environment Modeling the Physics of Damage Cluster Formation in a Cellular Environment Larry Toburen East Carolina University Why This Project Modern tools of radiobiology are leading to many new discoveries regarding how cells and tissues respond to radiation exposure. We can now irradiate single cells and observe responses in adjacent cells. We can also measure clusters of radiation damage produced in DNA. The primary tools available to describe the initial spatial pattern of damage formed by the absorption of ionizing radiation are based on (MC) Monte Carlo simulations of the structure of charged particle tracks. Although many MC codes exist and considerable progress is being made in the incorporation of detailed macromolecular target structures into these codes, much of the interaction

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Low Dose Radiation Research Program: Mechanisms of Tissue Response to Low  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Tissue Response to Low Dose Radiation Tissue Response to Low Dose Radiation Mary Helen Barcellos-Hoff Lawrence Berkeley National Laboratory Why This Project? In the past, the effects of ionizing radiation on humans has been attributed in great part to its ability to damage DNA, which transmits information from cell to cell, and generation to generation. Damaged DNA can lead to cell death or perpetuate the damage to daughter cells and to future generations. In addition to the information contained with the genome (i.e., DNA sequence), information directing cell behavior and tissue function is also stored outside the DNA. The success in cloning sheep from the DNA contained in the nucleus of an adult cell shows how important signals from the outside are in defining how the genome is expressed. This

222

US Environmental Protection Agency Radiation Protection Programs for Waste Management and Site Cleanup  

SciTech Connect (OSTI)

This paper provides an overview of the regulatory authorities of the Environmental Protection Agency's (EPA's) Office of Radiation and Indoor Air (ORIA) as they pertain to radioactive waste management and disposal, and cleanup of radioactively contaminated sites. It also describes several ORIA initiatives and examples of two of EPA's radioactive waste standards. (authors)

Clark, R.L. [Office of Radiation and Indoor Air (6608J), U.S. Environmental Protection Agency, Washington, D.C (United States)

2008-07-01T23:59:59.000Z

223

United States Office of EPA-520/1-88-020 Environmental Protection Radiation Program September 1988  

E-Print Network [OSTI]

and Dose Conversion Factors For Inhalation, Submersion, And Ingestion Federal Guidance Report No.11 #12 and Exposure-to-Dose Conversion Factors for General Application, Based on the 1987 Federal Radiation Protection) and Derived Air Concentrations (DAC) for Occupational Exposure 31 2.1 Exposure-to-Dose Conversion Factors

224

Radiation Exposure Monitoring Systems Program Policy for Submitting of PII information  

Broader source: Energy.gov [DOE]

The REMS Program Policy for submitting of PII information in accordance with the Office of Environment, Health, Safety and Security (EHSS) under DOE Order 231.1B and the REMS Reporting Guide.

225

Biological Systems Science Division (BSSD) | U.S. DOE Office of Science  

Office of Science (SC) Website

Biological and Environmental Research (BER) BER Home About Research Research Abstracts Searchable Archive of BER Highlights External link Biological Systems Science Division (BSSD) Genomic Science DOE Bioenergy Research Centers Radiochemistry & Imaging Instrumentation Radiobiology: Low Dose Radiation Research DOE Human Subjects Protection Program Structural Biology DOE Joint Genome Institute Climate and Environmental Sciences Division (CESD) Facilities Science Highlights Benefits of BER Funding Opportunities Biological & Environmental Research Advisory Committee (BERAC) News & Resources Contact Information Biological and Environmental Research U.S. Department of Energy SC-23/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3251 F: (301)

226

Radiation Control (Virginia)  

Broader source: Energy.gov [DOE]

The Department of Health is responsible for regulating radiation and radioactive materials in the Commonwealth of Virginia. Although the Department's Radiation Control Program primarily focuses on...

227

BIOLOGICAL SAFETY TABLE OF CONTENTS  

E-Print Network [OSTI]

SERVICES BIOLOGICAL AND CHEMICAL SAFETY PROGRAM...4 1.3 LABORATORY MANAGEMENT COMMITTEE.........................................5 2.0 GENERAL GUIDELINES FOR HANDLING BIOLOGICAL AGENTS...........................................................11 5.0 TRANSPORTATION AND TRANSFER OF BIOLOGICAL AGENTS ........................11 5.1 INTRODUCTION

O'Toole, Alice J.

228

Low Dose Radiation Research Program: A Variable-Energy Soft X-Ray  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

A Variable-Energy Soft X-Ray Microprobe to Investigate Mechanisms of A Variable-Energy Soft X-Ray Microprobe to Investigate Mechanisms of the Radiation-Induced Bystander Effect. Authors: Melvyn Folkard, Borivoj Vojnovic, Giuseppe Schettino, Kirk Atkinson, Kevin M Prise, Barry D Michael Institutions: Gray Cancer Institute, PO BO Box100, Mount Vernon Hospital, Northwood, HA6 2JR, UK The Gray Cancer Institute (GCI) has pioneered the use of X-ray focussing techniques to develop systems for micro-irradiating individual cells and sub-cellular targets. Our prototype X-ray microprobe was developed alongside our existing charged-particle microbeam to address problems specific to low LET radiations, or where very precise targeting accuracy and dose delivery are required. This facility was optimised for focusing 278 eV CK X-rays; however there are a number of reasons for extending the

229

Low Dose Radiation Research Program: Comparisons of IR and ROS for  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Comparisons of IR and ROS for Induction of Damage to Cells Comparisons of IR and ROS for Induction of Damage to Cells Kathryn D. Held1, Yvonne L. McCarey1, Laurence Tartier1, Elena V. Rusyn1, Giuseppe Schettino2, Melvyn Folkard2, Kevin M. Prise2, and Barry D. Michael2 1Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114; 2Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, HA6 2JR, UK Accurate evaluation of the risks associated with exposure to low doses of ionizing radiation (IR) is a major challenge for environmental sciences. Studies on the mechanisms of the actions of low doses of IR are needed to help understand possible risks. IR exerts its effects on cells through production of reactive oxidizing species (ROS) such as ·OH, H2O2 and

230

Low Dose Radiation Research Program: Low Dose Response of Respiratory Cells  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Response of Respiratory Cells in Intact Tissues and Reconstituted Response of Respiratory Cells in Intact Tissues and Reconstituted Tissue John Ford Department of Nuclear Engineering Texas A & M University Why this Project? Using the well-established rat trachea model to test the hypothesis that normal respiratory epithelial cells transmit signals to neighboring cells in response to very low dose radiation exposure. Project Goals By comparing the responses shown by cells in these normal rodent respiratory tissues to those seen for human respiratory epithelial cells in reconstituted tissue constructs, it will be possible to better understand the responds in human respiratory cells in vivo. These studies will characterize responses after exposure to a variety of radiation types and dose distributions. Experimental Approach

231

Low Dose Radiation Research Program: Low-Dose Dose-Response of  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Low-Dose Dose-Response of Proliferating Human Cells Exposed to Low Low-Dose Dose-Response of Proliferating Human Cells Exposed to Low Dose Rate g-Radiation. Authors: Louise Enns,1 Michael Weinfeld,1 Albert Murtha,1 and Kenneth Bogen2 Institutions: 1Cross Cancer Institute and 2Lawrence Livermore National Laboratory. Clinical and environmental exposure to ionizing radiation rarely exceeds 200 cGy. To examine cell proliferation at early times (up to 5 days) post-irradiation, we are utilizing an assay in which single cells encapsulated within ~30- to 70-µm-diameter agarose gel microdrops (GMDs) are exposed and cultured for 4 days at 37°C, then analyzed by flow cytometry (FC). Clonogenic proliferation is measured as the fraction of occupied GMDs containing multicellular microcolonies after 4 days in culture. This assay was applied to human A549 lung cells exposed to gamma

232

Atmospheric Radiation Measurement Program - unmanned aerospace vehicle: The follow-on phase  

SciTech Connect (OSTI)

Unmanned Aerospace Vehicle (UAV) demonstration flights (UDF) are designed to provide an early demonstration of the scientific utility of UAVs by using an existing UAV and instruments to measure broadband radiative flux profiles under clear sky conditions. UDF is but the first of three phases of ARM-UAV. The second phase significantly extends both the UAV measurement techniques and the available instrumentation to allow both multi-UAV measurements in cloudy skies and extended duration measurements in the tropopause. These activities build naturally to the third and final phase, that of full operational capability, i.e., UAVs capable of autonomous operations at 20-km altitudes for multiple days with a full suite of instrumentation for measuring radiative flux, cloud properties, and water vapor profiles.

Vitko, J. Jr. [Sandia National Labs., Livermore, CA (United States)

1995-04-01T23:59:59.000Z

233

Low Dose Radiation Research Program: Genetic Control of Repair and Adaptive  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Repair and Adaptive Responses to Low-level DNA Damage Repair and Adaptive Responses to Low-level DNA Damage James E. Haber Brandeis University Why This Project In order to fully understand mechanisms resulting in effects of low dose, whole system rather than cells must be examined. Although not identical to mammalian systems, simple systems usually have many similarities and give direction for further study of more complex systems. We use the budding yeast, Saccharomyces cerevisiae, as a model system because it is easy to manipulate and its genome is simple and well characterized. Project Goals Examine mechanisms and effects of low dose radiation response for: Genetic recombination mechanisms that lead to genomic instability Genetic factors that affect individual susceptibility to low-dose radiation The adaptive response

234

Long-Term Dosimetry of Solar UV Radiation in Antarctica with Spores of Bacillus subtilis  

Science Journals Connector (OSTI)

...biologically harmful ultraviolet radiation in Antarctica with a biological...hanced springtime ultraviolet radiation at Palmer Station, Ant- arctica...monitoring studies at Tokyo, Japan. J. Radiat. Res. 30:338-351...Ozone depletion: ultraviolet radiation and phytoplankton biology in...

Monika Puskeppeleit; Lothar E. Quintern; Saad el Naggar; Jobst-Ulrich Schott; Ute Eschweiler; Gerda Horneck; Horst Bcker

1992-08-01T23:59:59.000Z

235

A Comprehensive Quality Assurance Program for Personnel and Procedures in Radiation Oncology: Value of Voluntary Error Reporting and Checklists  

SciTech Connect (OSTI)

Purpose: This report describes the value of a voluntary error reporting system and the impact of a series of quality assurance (QA) measures including checklists and timeouts on reported error rates in patients receiving radiation therapy. Methods and Materials: A voluntary error reporting system was instituted with the goal of recording errors, analyzing their clinical impact, and guiding the implementation of targeted QA measures. In response to errors committed in relation to treatment of the wrong patient, wrong treatment site, and wrong dose, a novel initiative involving the use of checklists and timeouts for all staff was implemented. The impact of these and other QA initiatives was analyzed. Results: From 2001 to 2011, a total of 256 errors in 139 patients after 284,810 external radiation treatments (0.09% per treatment) were recorded in our voluntary error database. The incidence of errors related to patient/tumor site, treatment planning/data transfer, and patient setup/treatment delivery was 9%, 40.2%, and 50.8%, respectively. The compliance rate for the checklists and timeouts initiative was 97% (P<.001). These and other QA measures resulted in a significant reduction in many categories of errors. The introduction of checklists and timeouts has been successful in eliminating errors related to wrong patient, wrong site, and wrong dose. Conclusions: A comprehensive QA program that regularly monitors staff compliance together with a robust voluntary error reporting system can reduce or eliminate errors that could result in serious patient injury. We recommend the adoption of these relatively simple QA initiatives including the use of checklists and timeouts for all staff to improve the safety of patients undergoing radiation therapy in the modern era.

Kalapurakal, John A., E-mail: j-kalapurakal@northwestern.edu [Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois (United States); Zafirovski, Aleksandar; Smith, Jeffery; Fisher, Paul; Sathiaseelan, Vythialingam [Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois (United States)] [Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois (United States); Barnard, Cynthia [Department of Quality Strategies, Northwestern Memorial Hospital, Chicago, Illinois (United States)] [Department of Quality Strategies, Northwestern Memorial Hospital, Chicago, Illinois (United States); Rademaker, Alfred W. [Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois (United States)] [Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois (United States); Rave, Nick [Department of Physicians Services, Northwestern Memorial Hospital, Chicago, Illinois (United States)] [Department of Physicians Services, Northwestern Memorial Hospital, Chicago, Illinois (United States); Mittal, Bharat B. [Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois (United States)] [Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois (United States)

2013-06-01T23:59:59.000Z

236

Study of anticipated impact on DOE programs from proposed reductions to the external occupational radiation exposure limit  

SciTech Connect (OSTI)

A study of the impact of reducing the occupational radiation exposure limit from 5 rem/yr to 2.5, 1.0 and 0.5 rem/yr, respectively produced the following conclusions: reduction of the occupational exposure limit would result in significant increase in total accumulated exposure to the current radiation worker population and could require an increase in the work force; important programs would have to be abandoned at a planned exposure limit of 0.5 rem/yr; some engineering technology is not sufficiently developed to design or operate at the 0.5 rem/yr limit; even a factor of 2 reduction (2.5 rem/yr) would significantly increase costs and would result in an increase in total exposure to the work force; in addition to a significant one-time initial capital cost resulting from a 0.5 rem/yr limit, there would be a significant increase in annual costs; the major emphasis in controlling occupational exposure should be on further reduction of total man-rem; and current standards are used only as a limit. For example, 97% of the employees receive less than 0.5 rem/yr.

None

1981-02-01T23:59:59.000Z

237

Low Dose Radiation Research Program: U.S. Department of Energy -  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Search Publications Search Publications Year of Publication: Any 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1981 1980 1979 1978 1973 1970 1968 1956 Source: Select a Source... Journal of Mammary Gland Biology and Neoplasia 27th Annual CNS Conference and 30th CNS/CAN Student Conference, Toronto, Ontario, Canada Accounts of Chemical Research Acta Histochemica Acta Med. Nagasaki Advances in Medical Physics 2006 Advances in Space Research AJR, American J. of Roentgenology American Assoc. for Cancer Research American J. of Clinical Nutrition American J. of Epidemiology American J. of Human Genetics American J. of Pathology American Journal of Industrial Medicine American Journal of Physiology-Cell Physiology American Scientist

238

AN INTERNAL RADIATION DOSIMETRY COMPUTER PROGRAM, IDAC 2.0, FOR ESTIMATION OF PATIENT DOSES FROM RADIOPHARMACEUTICALS  

Science Journals Connector (OSTI)

......dose to estimate the radiation risk from a diagnostic...grant from the Swedish Radiation Safety Authority [grant number...second-generation personal computer software for internal dose assessment...Radiological Protection. Radiation dose to patients from......

M. Andersson; L. Johansson; D. Minarik; S. Mattsson; S. Leide-Svegborn

2013-12-01T23:59:59.000Z

239

Low Dose Radiation Research Program: A Variable-Energy Soft X-Ray  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

A Variable-Energy Soft X-Ray Microprobe to Investigate Mechanisms of A Variable-Energy Soft X-Ray Microprobe to Investigate Mechanisms of the Radiation -Induced Bystander Effect. Authors: Melvyn Folkard, Borivoj Vojnovic, Giuseppe Schettino, Kirk Atkinson, Kevin M Prise, Barry D Michael Institutes: Gray Cancer Institute, PO Box 100, Mount Vernon Hospital, Northwood, HA6 2JR, UK For over a decade, the Gray Cancer Institute (GCI) has been actively engaged in the development and use of micro-irradiation techniques applied to radiobiological research. Our initial investigations made use of a charged-particle microbeam capable of irradiating individual cells with collimated energetic protons or 3He ions. By the end of the 1990's, a second facility had been constructed, which uses diffractive X-ray optics to focus ultrasoft X-rays to a sub-micron spot. The X-ray microprobe was

240

Low Dose Radiation Research Program: Real-time Study of Signal Transduction  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Real-time Study of Signal Transduction Pathways Involving in Real-time Study of Signal Transduction Pathways Involving in Bystander Effects Using Single Nanoparticle Optics and Single Living Cell Imaging Authors: Prakash D. Nallathamby, X. Nancy Xu, Mohan Natarajan Institutions: Department of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia and Department of Radiation Oncology, The University of Texas Health Science Center, San Antonio, Texas The mechanisms of bystander effects remain largely unknown. Bystander responses are thought to depend on activation of cellular communication processes. Recent studies have speculated that several crucial signal transduction pathways could play a major role in bystander effects. These crucial signal transduction pathways are controlled by a coordinated

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Strictly for the Birds: Science, the Military and the Smithsonians Pacific Ocean Biological Survey Program, 19631970  

Science Journals Connector (OSTI)

Between 1963 and 1970, the Smithsonian Institution held a grant from the US Army to observe migratory patterns of pelagic birds in the Central Pacific. For six years, the Pacific Ocean Biological Survey Progra...

Roy MacLeod

2001-01-01T23:59:59.000Z

242

Strictly for the Birds: Science, the Military and the Smithsonian's Pacific Ocean Biological Survey Program, 19631970  

Science Journals Connector (OSTI)

Between 1963 and 1970, the Smithsonian Institution held a grant from the US Army to observe migratory patterns of pelagic birds in the Central Pacific. For six years, the Pacific Ocean Biological Survey Progra...

Roy MacLeod

243

Final Technical Report for Chief Scientist for Atmospheric Radiation Measurement (ARM) Aerial Vehicle Program (AVP)  

SciTech Connect (OSTI)

The major responsibilities of the PI were identified as 1) the formulation of campaign plans, 2) the representation of AVP in various scientific communities inside and outside of ARM and the associated working groups, 3) the coordination and selection of the relative importance of the three different focus areas (routine observations, IOPs, instrument development program), 4) the examination and quality control of the data collected by AVP, and 5) providing field support for flight series. This report documents the accomplishments in each of these focus areas for the 3 years of funding for the grant that were provided.

Greg M. McFarquhar

2011-10-21T23:59:59.000Z

244

Atmospheric Radiation Measurement (ARM) Data from Specific Instruments Used in the ARM Program  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

ARM is known for its comprehensive set of world-class, and in some cases, unique, instruments available for use by the global scientific community. In addition to the ARM instruments, the ARM Climate Research Facility identifies and acquires a wide variety of data including model, satellite, and surface data, from "external instruments," to augment the data being generated within the program. External instruments belong to organizations that are outside of the ARM Program. Field campaign instruments are another source of data used to augment routine observations. The huge archive of ARM data can be organized by instrument categories into twelve "collections:" Aerosols, Airborne Observations, Atmospheric Carbon, Atmospheric Profiling, Cloud Properties, Derived Quantities and Models, Ocean Observations, Radiometric, Satellite Observations, Surface Meteorology, Surface/Subsurface Properties, and Other. Clicking on one of the instrument categories leads to a page that breaks that category down into sub-categories. For example, "Atmospheric Profiling" is broken down into ARM instruments (with 11 subsets), External Instruments (with 6 subsets), and Field Campaign Instruments (with 42 subsets). Each of the subset links, in turn, leads to detailed information pages and links to specific data streams. Users will be requested to create a password, but the data files are free for viewing and downloading.

245

Faculty of Science Biology and Biotechnology  

E-Print Network [OSTI]

Faculty of Science Biology and Biotechnology Biology is one of the Life Sciences, which describe investigation and theoretical explanation. www.uwindsor.ca/biology Biotechnology is the synthesis of important biological molecules using living systems. Rigorous, Enriching Programs The Biology and Biotechnology program

246

Marine Biology  

E-Print Network [OSTI]

this door. Marine Biology I joined the military RIVERSIDE Marine Biology A Thesis submitted in partialBiology

Zaffino, Kyle

2013-01-01T23:59:59.000Z

247

Incorporating biologic measurements (SF2, CFE) into a tumor control probability model increases their prognostic significance: a study in cervical carcinoma treated with radiation therapy  

Science Journals Connector (OSTI)

Purpose: To assess whether incorporation of measurements of surviving fraction at 2 Gy (SF2) and colony-forming efficiency (CFE) into a tumor control probability (tcp) model increases their prognostic significance. Methods and Materials: Measurements of SF2 and CFE were available from a study on carcinoma of the cervix treated with radiation alone. These measurements, as well as tumor volume, dose, and treatment time, were incorporated into a Poisson tcp model (tcp?,?). Regression analysis was performed to assess the prognostic power of tcp?,? vs. the use of either tcp models with biologic parameters fixed to best-fit estimates (but incorporating individual dose, volume, and treatment time) or the use of SF2 and CFE measurements alone. Results: In a univariate regression analysis of 44 patients, tcp?,? was a better prognostic factor for both local control and survival (p CFE alone (p = 0.015 for local control, p = 0.38 for survival). In multivariate analysis, tcp?,? emerged as the most important prognostic factor for local control (p CFE was still a significant independent prognostic factor for local control, whereas SF2 was not. The sensitivities of tcp?,? and SF2 as predictive tests for local control were 87% and 65%, respectively. Specificities were 70% and 77%, respectively. Conclusions: A Poisson tcp model incorporating individual SF2, CFE, dose, tumor volume, and treatment time was found to be the best independent prognostic factor for local control and survival in cervical carcinoma patients.

Francesca Meteora Buffa; Susan E. Davidson; Robert D. Hunter; Alan E. Nahum; Catharine M.L. West

2001-01-01T23:59:59.000Z

248

Program Contacts | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

Program Program Contacts Biological and Environmental Research (BER) BER Home About Staff Program Contacts Organization Chart .pdf file (172KB) BER Budget BER Committees of Visitors Directions Jobs Research Facilities Science Highlights Benefits of BER Funding Opportunities Biological & Environmental Research Advisory Committee (BERAC) News & Resources Contact Information Biological and Environmental Research U.S. Department of Energy SC-23/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3251 F: (301) 903-5051 E: sc.ber@science.doe.gov More Information » Staff Program Contacts Print Text Size: A A A RSS Feeds FeedbackShare Page Program Program Manager Telephone Email Atmospheric Radiation Measurement (ARM) Climate Research Facility Wanda Ferrell, Ph.D.

249

Biological Control of Saltcedar  

E-Print Network [OSTI]

infesting the Pecos River has been treated recently with aerially applied herbicides. Plans are to expand this program to the Colorado River and other areas. Biological control can complement these herbicide programs, as the beetles can help suppress... saltcedar trees to justify the cost of aerial sprays. Cooperating agencies The Saltcedar Biological Control Program in Texas is a cooperative effort among many federal, state, public and private agencies and groups. The USDA-Agricultural Research Service...

Knutson, Allen E.; DeLoach, C. Jack; Muegge, Mark A.

2003-10-21T23:59:59.000Z

250

DOE/EA-1193: Environmental Assessment for the Atmospheric Radiation Measurement (ARM) Program North Slope of Alaska and Adjacent Artic Ocean Cloud and Radiation Testbed (CART) Site (February 1997)  

Broader source: Energy.gov (indexed) [DOE]

u. S. DEPARTMENT OF ENERGY u. S. DEPARTMENT OF ENERGY FINDING OF NO SIGNIFICANT IMPACT FINAL ENVIRONMENTAL ASSESSMENT - The United States Department of Energy (DOE) has prepared an environmental assessment (EA) for the Atmospheric Radiation Measurement Cloud and Radiation Testbed (ARM/CART), North Slope of Alaska and Adjacent Arctic Ocean. The purpose of the ARM/CART program is to collect and analyze atmospheric data for the development and validation of global climate change models. The program involves construction of several small facilities and operation of sensing equipment. The EA analyzes the impacts on land use, tundra, air quality, cultura.l resources, socioeconomics, and wildlife. Separate studies (summarized in the EA) were also conducted to ensure that the operation of the facilities would not

251

Molecular Scissors: Restriction Enzymes 2009 1 Minority Science Programs School of Biological Sciences University of California, Irvine  

E-Print Network [OSTI]

Molecular Scissors: Restriction Enzymes 2009 1 Minority Science Programs a group of enzymes (proteins that aid chemical reactions) in bacteria, which when added to any DNA result fragmented. These "molecular scissors" are called restriction enzymes (RE) How Restriction Enzymes

Rose, Michael R.

252

Appendix F: Radiation Appendix F: Radiation F-3  

E-Print Network [OSTI]

. People are exposed to naturally occurring radiation constantly. For example, cosmic radiation; radon effects on the environment and biological systems. Radiation comes from natural and human-made sourcesAppendix F: Radiation #12;#12;Appendix F: Radiation F-3 P P P E E E N NN HYDROGEN ATOM DEUTERIUM

Pennycook, Steve

253

Appendix F: Radiation Appendix F: Radiation F-3  

E-Print Network [OSTI]

to naturally occurring radiation constantly. For example, cosmic radiation; radon in air; potassium in food on the environment and biological systems. Radiation comes from natural and human-made sources. People are exposedAppendix F: Radiation #12;#12;Appendix F: Radiation F-3 Fig. F.1. The hydrogen atom and its

Pennycook, Steve

254

Biology and Medicine Division annual report, 1985  

SciTech Connect (OSTI)

This book briefly describes the activities of the Biology and Medicine Division of the Lawrence Berkeley Laboratory. During the past year the Donner Pavilion program on the treatment of arteriovenous malformations in the brain has chalked up very significant successes. The disease control rate has been high and objective measures of success using cerebral angiography have been established. The new high resolution positron emitting tomographic imager has been demonstrated to operate successfully. In the Radiation Biophysics program, the availability of higher mass ions up to uranium has allowed us cell and tissue studies in a radiation domain that is entirely new. Using uranium beams, investigators have already made new and exciting findings that are described in the body of the report.

Not Available

1986-04-01T23:59:59.000Z

255

Programming  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

provided on the Cray systems at NERSC. The Programming Environment is managed by a meta-module named similar to "PrgEnv-gnu4.6". The "gnu" indicates that it is providing the GNU...

256

Biology and Medicine Division annual report, 1981-1982. [Lead abstract  

SciTech Connect (OSTI)

Separate abstracts were prepared for the 61 research reports in the 1981-1982 annual report for the Biology and Medicine Division of the Lawrence Berkeley Laboratory. Programs reviewed include research medicine, Donner Pavilion, environmental physiology, radiation biophysics and structural biophysics. (KRM)

Not Available

1983-04-01T23:59:59.000Z

257

BIOLOGICAL SCIENCES Contemporary biological science  

E-Print Network [OSTI]

BIOLOGICAL SCIENCES Contemporary biological science covers a range of diverse and overlapping in cellular and molecular biology. Wichita State University's Department of Biological Sciences offers courses in most aspects of contemporary biological science. Our required core courses will expose you

258

Atmospheric Radiation Measurement Program  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

U U r r b b a a n n A A t t m m o o s s p p h h e e r r i i c c O O b b s s e e r r v v a a t t o o r r y y ( ( U U A A O O ) ) F F i i r r s s t t P P l l a a n n n n i i n n g g W W o o r r k k s s h h o o p p - - A A t t t t e e n n d d e e e e s s 2 2 7 7 - - 2 2 8 8 J J a a n n u u a a r r y y , , 2 2 0 0 0 0 3 3 ****************************************************************** Sean Ahearn Hunter College North Bldg., 10 th Floor New York City, NY sca@everest.hunter.cuny.edu (W) 212-772-5327 Robert Bornstein San Jose State University Dept. of Meteorology San Jose, CA 951920-0104 pblmodel@hotmail.com (W) 408-924-5205 (F) 408-924-5191 David Brown Argonne National Lab 9700 S. Cass Avenue Argonne, IL 60439 dbrown@anl.gov (W) 608-442-1249 Michael Brown LANL, Drop Point 19S, SM-30 Bikini Atoll Road Group D4-MS F604 Los Alamos, NM 87545 mbrown@lanl.gov (W) 505- 667-1788

259

Radiation Protection Programs Guide  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

This Guide amplifies the regulatory requirements of 10 CFR 835 and provides explanations and examples of the basic requirements for implementing the requirements of 10 CFR 835. Cancels DOE G 441.1-1A, DOE G 441.1-2, DOE G 441.1-3A, DOE G 441.1-4A, DOE G 441.1-5, DOE G 441.1-6, DOE G 441.1-7, DOE G 441.1-8, DOE G 441.1-9, DOE G 441.1-10, DOE G 441.1-11, DOE G 441.1-12, DOE G 441.1-13. Canceled by DOE G 441.1-1C.

2007-03-01T23:59:59.000Z

260

Atmospheric Radiation Measurement Program  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

models. As an important factor in growing crops, soil moisture dictates a farmer's success or failure. Too much soil moisture can drown out croplands and cause flooding,...

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Hydrogen peroxide significantly contributes to radiation-induced genomic instability  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

peroxide significantly contributes to radiation- peroxide significantly contributes to radiation- induced genomic instability Disha Dayal 1 , Sean M. Martin 1 , Sujatha Venkataraman 1 , Charles L. Limoli 2 , Douglas R Spitz 1 . 1 Free Radical and Radiation Biology Program, The University of Iowa, Iowa City, IA- 52246, 2 Department of Radiation Oncology, The University of California, Irvine, CA-92697 Chronic metabolic oxidative stress is associated with genomic instability following exposure to ionizing radiation (IR). Mitochondria have long been known to be a major source of reactive oxygen species (ROS) capable of causing oxidative stress. We hypothesized that radiation damages mitochondria, leading to oxidative stress and eventually genomic instability. This hypothesis is based on preliminary studies in parental

262

High performance computing and communications Grand Challenges program: Computational structural biology. Final report, August 15, 1992--January 14, 1997  

SciTech Connect (OSTI)

The Grand Challenge project consists of two elements: (1) a hierarchical methodology for 3D protein structure prediction; and (2) development of a parallel computing environment, the Protein Folding Workbench, for carrying out a variety of protein structure prediction/modeling computations. During the first three years of this project the author focused on the use of selected proteins from the Brookhaven Protein Data Base (PDB) of known structures to provide validation of the prediction algorithms and their software implementation, both serial and parallel. Two proteins in particular have been selected to provide the project with direct interaction with experimental molecular biology. A variety of site-specific mutagenesis experiments are performed on these two proteins to explore the many-to-one mapping characteristics of sequence to structure.

Solomon, J.E.

1997-10-02T23:59:59.000Z

263

Third report on the Oak Ridge National Laboratory Biological Monitoring and Abatement Program for White Oak Creek Watershed and the Clinch River  

SciTech Connect (OSTI)

As a condition of the National Pollutant Discharge Elimination System (NPDES) permit issued to Oak Ridge National Laboratory (ORNL) on April 1, 1985, a Biological Monitoring and Abatement Program (BMAP) was developed for White Oak Creek (WOC); selected tributaries of WOC, including Fifth Creek, First Creek, Melton Branch, and Northwest Tributary; and the Clinch River. The BMAP currently consists of six major tasks that address both radiological and nonradiological contaminants in the aquatic and terrestrial environs at ORNL. These are (1) toxicity monitoring, (2) bioaccumulation monitoring of nonradiological contaminants in aquatic biota, (3) biological indicator studies, (4) instream ecological monitoring, (5) assessment of contaminants in the terrestrial environment, and (6) radioecology of WOC and White Oak Lake (WOL). The investigation of contaminant transport, distribution, and fate in the WOC embayment-Clinch River-Watts Bar Reservoir system was originally a task of the BMAP but, in 1988, was incorporated into the Resource Conservation and Recovery Act Facility Investigation for the Clinch River, a separate study to assess offsite contamination from all three Department of Energy facilities in Oak Ridge.

Loar, J.M. [ed.] [ed.; Adams, S.M.; Bailey, R.D. [and others] [and others

1994-03-01T23:59:59.000Z

264

Nonlinear Radiating Instability of a Barotropic Eastern Boundary Current Massachusetts Institute of Technology/WHOI Joint Program, Cambridge, Massachusetts  

E-Print Network [OSTI]

. Gill et al. (1974) noted that the potential energy of large-scale wind-driven gyres in the ocean to the ocean interior. The radiated instabilities can generate zonal striations in the ocean interior for the nonlinear resonance between the radiating and trapped modes, but more general nonlinear triad interactions

265

Biophysics and synchrotron radiation  

SciTech Connect (OSTI)

This book, contains contributions to the conference on Biophysics and Synchrotron Radiation held in July 1986 at Frascati. It is devoted to advances in the resolution of biological molecule structure obtainable through synchroton radiation studies. The use of synchroton radiation has firmly established x-ray spectroscopy of biological molecules. More detailed knowledge on the local structure of active sites of metalloproteins, as well as a number of studies on the interaction of metal ions with other important biological macromolecular systems are presented. This new method for protein structure analysis is a major improvement for the rapidly expanding field of protein engineering.

Bianconi, A.; Castellano, C.C.

1987-01-01T23:59:59.000Z

266

Low Dose Radiation Research Program: Regulation of NF-kB and MnSOD in Low  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

NF-kB and MnSOD in Low Dose Radiation-Induced Adaptive NF-kB and MnSOD in Low Dose Radiation-Induced Adaptive Responses in Mouse and Human Skin Cells Jian Jian Li School of Health Sciences, Purdue University West Lafayette, Indiana Why this Project? To determine if low dose ionizing radiation-induced adaptive responses in skin cells are mediated by activation of signaling networks. Project Goals To evaluate the signaling networks involving transcription factor NF-kB and the mitochondrial antioxidant protein MnSOD. To determine if NF-kB is activated by low dose radiation in vivo. To determine if NF-kB activation is critical in the pathways that produce adaptive responses. Experimental Approach Cells transfected with NF-kB luciferase responder genes will be used to define a dose-response relationship for activation of the NF-kB gene. NF-kB

267

Appendix G: Radiation HYDROGEN ATOM  

E-Print Network [OSTI]

. People are exposed to naturally occurring radiation constantly. For example, cosmic radiation; radon effects on the environment and biological systems. Radiation comes from natural and human-made sourcesAppendix G: Radiation #12;#12;P P P E E E N NN HYDROGEN ATOM DEUTERIUM ATOM TRITIUM ATOM HYDROGEN

Pennycook, Steve

268

Appendix A: Radiation HYDROGEN ATOM  

E-Print Network [OSTI]

. People are exposed to naturally occurring radiation constantly. For example, cosmic radiation; radon effects on the environment and biological systems. Radiation comes from natural and human-made sourcesAppendix A: Radiation #12;P P P E E E N NN HYDROGEN ATOM DEUTERIUM ATOM TRITIUM ATOM HYDROGEN

Pennycook, Steve

269

Remaining Sites Verification Package for the 100-F-36, 108-F Biological Laboratory, and for the 116-F-15, 108-F Radiation Crib, Waste Site Reclassification Form 2007-003  

SciTech Connect (OSTI)

The 116-F-15 waste site is the former location of the 108-F Radiation Crib that was located in the first floor of the 108-F Biological Laboratory. In accordance with this evaluation, the verification sampling results support a reclassification of this site to Interim Closed Out. The current site conditions achieve the remedial action objectives and the corresponding remedial action goals established in the Remaining Sites ROD. The results of verification sampling show that residual contaminant concentrations do not preclude any future uses and allow for unrestricted use of shallow zone soils. The results also demonstrate that residual contaminant concentrations are protective of groundwater and the Columbia River.

L. M. Dittmer

2007-05-24T23:59:59.000Z

270

Program  

Office of Scientific and Technical Information (OSTI)

Extremophiles 2004 Extremophiles 2004 5th International Conference on Extremophiles SEPTEMBER 19 -23, 2004 CAMBRIDGE, MARYLAND Extremophiles 2004 5th International Conference on Extremophiles © 2004, American Society for Microbiology 1752 N Street, N.W. Washington, DC 20036-2904 Phone: 202-737-3600 World Wide Web: www.asm.org All Rights Reserved Printed in the United States of America ISBN: 1-55581 324-0 TABLE OF CONTENTS General Information Scientific Program Abstracts for Oral Sessions Abstracts for Poster Sessions Index 4 10 18 42 144 4 ASM Conferences EXECUTIVE COMMITTEE Frank Robb, Chair University of Maryland Biotechnology Institute Michael W. Adams University of Georgia Koki Horikoshi Japan Agency for Marine-Earth Science and Technology Robert M. Kelly North Carolina State University Jennifer Littlechild

271

Genomics and Systems Biology  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Genomics and Systems Biology Genomics and Systems Biology Genomics and Systems Biology Los Alamos scientists perform research in functional genomics and structural genomics, and applications for such work cover diverse fields such as energy, agriculture, and environmental cleanup. Get Expertise Babetta Marrone Biofuels Program Manager Email Cheryl Kuske DOE BER Biological System Science Division Program Manager Email Chris Detter Emerging Threats Program Manager: Email Rebecca McDonald Bioscience Communications Email "We were asked to build a rocket ship," said developer Joel Berendzen, "but instead we built a 10,000 mph motorcycle." - Sequedex team LANL leads the world in computational finishing of microbial genomes Protein research Read caption + In 2013, Los Alamos scientist Richard Sayre and his team genetically

272

Neutron interactions with biological tissue. Final report  

SciTech Connect (OSTI)

This program was aimed at creating a quantitative physical description, at the micrometer and nanometer levels, of the physical interactions of neutrons with tissue through the ejected secondary charged particles. The authors used theoretical calculations whose input includes neutron cross section data; range, stopping power, ion yield, and straggling information; and geometrical properties. Outputs are initial and slowing-down spectra of charged particles, kerma factors, average values of quality factors, microdosimetric spectra, and integral microdosimetric parameters such as {bar y}{sub F}, {bar y}{sub D}, y{sup *}. Since it has become apparent that nanometer site sizes are also relevant to radiobiological effects, the calculations of event size spectra and their parameters were extended to these smaller diameters. This information is basic to radiological physics, radiation biology, radiation protection of workers, and standards for neutron dose measurement.

NONE

1998-02-17T23:59:59.000Z

273

Radiation Induced Mammary Cancer  

Science Journals Connector (OSTI)

......Induced Mammary Cancer R.L. Ullrich * R.J. Preston # * Department of Radiation Therapy, University of Texas Medical Branch, Galveston, TX 77550 # Biology Division Oak Ridge National Laboratory Oak Ridge, TN 37831, U.S.A Over the last......

R.L. Ullrich; R.J. Preston

1991-12-01T23:59:59.000Z

274

Fundamentals of health physics for the radiation-protection officer  

SciTech Connect (OSTI)

The contents of this book on health physics include chapters on properties of radioactive materials, radiation instrumentation, radiation protection programs, radiation survey programs, internal exposure, external exposure, decontamination, selection and design of radiation facilities, transportation of radioactive materials, radioactive waste management, radiation accidents and emergency preparedness, training, record keeping, quality assurance, and appraisal of radiation protection programs. (ACR)

Murphy, B.L.; Traub, R.J.; Gilchrist, R.L.; Mann, J.C.; Munson, L.H.; Carbaugh, E.H.; Baer, J.L.

1983-03-01T23:59:59.000Z

275

Internal Dosimetry Program Guide for Use with Title 10, Code of Federal Regulations, Part 835, Occupational Radiation Protection  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

This Guide provides an acceptable methodology for establishing and operating an internal dosimetry program that will comply with DOE requirements specified in 10 CFR 835. Cancels: DOE G 441.1-3

2005-06-11T23:59:59.000Z

276

External Dosimetry Program Guide for Use with Title 10, Code of Federal Regulations, Part 835, Occupational Radiation Protection  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

This Guide provides an acceptable methodology for establishing and operating an external dosimetry program that will comply with DOE requirements specified in 10 CFR 835. Cancels: DOE G 441.1-4

2005-06-11T23:59:59.000Z

277

2013-2014 Handbook Stem Cell Biology and Regenerative  

E-Print Network [OSTI]

2013-2014 Handbook Stem Cell Biology and Regenerative Medicine Interdisciplinary Graduate Program and yet focus specifically on fundamentals of biology and medicine necessary for a successful career

Puglisi, Joseph

278

DOE Hydrogen Program Overview | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

DOE Hydrogen Program Overview DOE Hydrogen Program Overview A prospectus for biological H2 production for the DOE Annual Program Review Meeting. photobiological.pdf More Documents...

279

Upper San Juan Basin Biological Assessment  

E-Print Network [OSTI]

the biological assessment. The Colorado Natural Heritage Program began its research by updating its BiologicalUpper San Juan Basin Biological Assessment Colorado State University 8002 Campus Delivery Fort Collins, CO 80523-8002 June 2003 Colorado Natural Heritage Program #12;Southwest Land Alliance Pagosa

280

DOE 2013 Occupational Radiation Exposure Report  

Office of Environmental Management (EM)

available on the U.S. Department of Energy Radiation Exposure Monitoring System Program Web Site at: http:energy.govehssoccupational-radiation-exposure Foreword iii MATTHEW B....

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

10 CFR 835- Occupational Radiation Protection  

Broader source: Energy.gov [DOE]

The rules in this part establish radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of DOE activities.

282

Code of Federal Regulations OCCUPATIONAL RADIATION PROTECTION  

Broader source: Energy.gov [DOE]

The rules in this part establish radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of DOE activities.

283

extremely low-dose ionizing radiation upregulates CXC chemokines in normal human fibroblasts  

Science Journals Connector (OSTI)

...2006 Abstract Tumor Biology 32: Radiation Biology 2 Proc Amer Assoc Cancer...Volume 47, 2006 extremely low-dose ionizing radiation upregulates CXC chemokines in...biological effects of this low dose range have not been established. We...

Akira Fujimori; Katsutoshi Suetomi; Keiji Kinoshita; Ayako Kojima; Yaqun Fang; Ayako Egusa; and Ryuichi Okayasu

2006-04-15T23:59:59.000Z

284

Pattern of Radiation-induced RET and NTRK1 Rearrangements in 191 Post-Chernobyl Papillary Thyroid Carcinomas: Biological, Phenotypic, and Clinical Implications  

Science Journals Connector (OSTI)

...as a result of fallout from thermonuclear explosions at the Marshall...genes. PTC1 consists of the fusion of the RET TK domain with...to fallout radiation from a thermonuclear explosion. Stem Cells (Dayton...transforming sequence formed by the fusion of ret tyrosine kinase and...

Hartmut M. Rabes; Evgenij P. Demidchik; Juri D. Sidorow; Edmund Lengfelder; Claudia Beimfohr; Dieter Hoelzel; and Sabine Klugbauer

2000-03-01T23:59:59.000Z

285

The central focus of the graduate program in Biochemistry and Molecular Biophysics (BMB) is the relationship between biological form and function at a fundamental level. This  

E-Print Network [OSTI]

(including Biochemistry and Biophysics, Physiology, Medicine, Pharmacology, Radiology, and Cell and Developmental Biology); from the Schools of Dental and Veterinary Medicine; from the School of Arts and Sciences

Sharp, Kim

286

CDC25B and p53 Are Independently Implicated in Radiation Sensitivity for Human Esophageal Cancers  

Science Journals Connector (OSTI)

...address: Division of Radiation Biology, Kanazawa University, Kanazawa, Japan. 3 To whom requests...address: Division of Radiation Biology, Kanazawa University, Kana- zawa, Japan. 9To whom requests...6-thioguanine; UV, ultraviolet radiation (254 nm). 9, 10...

Hiroshi Miyata; Yuichiro Doki; Hitoshi Shiozaki; Msatoshi Inoue; Msahiko Yano; Yoshiyuki Fujiwara; Hirofumi Yamamoto; Kiyonori Nishioka; Kentaro Kishi; and Morito Monden

2000-12-01T23:59:59.000Z

287

Radiological Health Program (New Hampshire)  

Broader source: Energy.gov [DOE]

The Statute establishes programs and procedures for regulation of sources of radiation within the state, among states, and between the federal government and the state. A regulatory program...

288

Biological & Environmental Research Abstracts Database  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ABBREVIATION DESCRIPTION ABBREVIATION DESCRIPTION AAVP ARM Aerial Vehicles Program ACP Atmospheric Chemistry Program ACP - CE ACP - Capital Equipment AmeriFlux AmeriFlux ARM Atmospheric Radiation Measurement (ARM) ARM - CE ARM - Capital Equipment ARM – Facility Atmospheric Radiation Measurement Climate Research Facility ARM – Facility- CCRI Atmospheric Radiation Measurement Climate Research Facility (Climate Change Research Initiative) ARM - Science Atmospheric Radiation Measurement Science Program ARM-CCRI ARM-CCRI ARM-Infrastr Atmospheric Radiation Measurement-Infrastructure Artificial Retina ASP Atmospheric Science Program

289

Radiation-Induced Bystander Effects and Relevance to Human Radiation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Radiation-Induced Bystander Effects and Relevance to Human Radiation Radiation-Induced Bystander Effects and Relevance to Human Radiation Exposures Review of phenomenon appears in Radiation Research Pamela Sykes and Benjamin Blyth One concern of radiobiologists is the effect radiation exposure might have on nearby unirradiated cells. For example, when only a small fraction of cells are directly hit by radiation energy, are the surrounding unirradiated cells also at an increased risk of cancer? The term "radiation-induced bystander effect" is used to describe radiation-induced biological changes that occur in unirradiated cells within an irradiated cell population. Radiation-induced bystander effects have become established in the vernacular and are considered as an authentic radiation response. However, there is still no consensus on a precise definition of the term, which

290

Synthetic biology and crop engineering  

Broader source: Energy.gov [DOE]

Breakout Session 2: Frontiers and Horizons Session 2-A: Synthetic Biology and the Promise of Biofuels Jonathan Burbaum, Program Director, Department of Energy, Office of Science, ARPAE

291

Guidelines Graduate Studies In Biology  

E-Print Network [OSTI]

Department of Biology Virginia Commonwealth University 1000 W. Cary St. Richmond, VA 23284-2012 Telephone: Application for Independent Study (BIOL 692) 19 #12;1 Introduction This document is intended to serve. The Master of Science program for the graduate student in biology is administered by the College

Bukaveckas, Paul A.

292

Risk Estimation; Background Radiation (Natural and Artificial )  

E-Print Network [OSTI]

-threshold mode estimate the response at lower doses. · The Committee on Biological Effects of Ionizing RadiationModule 9 Risk Estimation; Background Radiation (Natural and Artificial ) · sources of background radiation · various risk models. · estimating risk and on the sources of background radiation, both

Massey, Thomas N.

293

Radiation Health Physics Four Year Plan  

E-Print Network [OSTI]

Radiation Health Physics Four Year Plan 2011-12 Radiation Health Physics (42 hrs) CH Grade Shielding Ext Dosimetry RHP 475 4 Project-Nuc Syst Design RHP 481 4 Radiation Protection Western Culture (3): RHP 483 4 Radiation Biology RHP 488 3 Radioecology Skills (12 hrs) CH Grade Writing I: WR 121 English

Tullos, Desiree

294

RHOBOT: Radiation hardened robotics  

SciTech Connect (OSTI)

A survey of robotic applications in radioactive environments has been conducted, and analysis of robotic system components and their response to the varying types and strengths of radiation has been completed. Two specific robotic systems for accident recovery and nuclear fuel movement have been analyzed in detail for radiation hardness. Finally, a general design approach for radiation-hardened robotics systems has been developed and is presented. This report completes this project which was funded under the Laboratory Directed Research and Development program.

Bennett, P.C.; Posey, L.D. [Sandia National Labs., Albuquerque, NM (United States)

1997-10-01T23:59:59.000Z

295

Biological Systems  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biological Processing and Manufacturing The bioloical processing and manufacturing research being performed at the Idaho National Laboratory is primarily focused on using...

296

Fuel Cell Technologies Office: Biological Hydrogen Production Workshop  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biological Hydrogen Biological Hydrogen Production Workshop to someone by E-mail Share Fuel Cell Technologies Office: Biological Hydrogen Production Workshop on Facebook Tweet about Fuel Cell Technologies Office: Biological Hydrogen Production Workshop on Twitter Bookmark Fuel Cell Technologies Office: Biological Hydrogen Production Workshop on Google Bookmark Fuel Cell Technologies Office: Biological Hydrogen Production Workshop on Delicious Rank Fuel Cell Technologies Office: Biological Hydrogen Production Workshop on Digg Find More places to share Fuel Cell Technologies Office: Biological Hydrogen Production Workshop on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Program Presentations Multimedia Conferences & Meetings

297

DEGREE REQUIREMENTS BIOLOGICAL ENGINEERING TECHNOLOGY  

E-Print Network [OSTI]

DEGREE REQUIREMENTS BIOLOGICAL ENGINEERING TECHNOLOGY ENVIRONMENTAL ENGINEERING TECHNOLOGY The curriculum in the technology programs must satisfy the College of Agriculture and Life Sciences (CALS for the technology programs are listed by subject matter in three major categories: (A) Basic Subjects, (B) Advanced

Walter, M.Todd

298

The Division of Biology & Biomedical Sciences  

E-Print Network [OSTI]

The Division of Biology & Biomedical Sciences what will YOU discover? #12;620students more than 470faculty 36departments 12programs and one YOU. DBBS Division of Biology and Biomedical Sciences Washington. The Division of Biology and Biomedical Sciences (DBBS) is ideally positioned to foster the interdisciplinary

Kornfeld, S. Kerry

299

Programs | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

Programs Programs Programs Home Advanced Scientific Computing Research Basic Energy Sciences Biological and Environmental Research Fusion Energy Sciences High Energy Physics...

300

MASTER OF ENGINEERING Biological and Environmental Engineering  

E-Print Network [OSTI]

Marchewka, Student Services Coordinator Department of Biological and Environmental Engineering 207 RileyMASTER OF ENGINEERING Biological and Environmental Engineering Program Requirements Fall 2014 The Master of Engineering (MEng) is a professional degree program intended for those who have a Bachelors

Walter, M.Todd

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

MASTER OF ENGINEERING Biological and Environmental Engineering  

E-Print Network [OSTI]

Marchewka, Student Services Coordinator Department of Biological and Environmental Engineering 207 RileyMASTER OF ENGINEERING Biological and Environmental Engineering Program Requirements Fall 2013 The Master of Engineering (MEng) is a professional degree program intended for those who have a Bachelors

Walter, M.Todd

302

E-Print Network 3.0 - applying radiation safety Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Radiation Safety RD-29 Rev. 1 May 2009 Radiation... ) program at UC Berkeley, radiation safety, potential hazards, and emergency procedures. After reading... material spill or...

303

Appendix E. Radiation Annual Site Environmental Report--2011  

E-Print Network [OSTI]

and biological systems. Radiation comes from natural and human-made sources. People are exposed to naturally occurring radiation constantly. For example, cosmic radiation; radon in air; potassium in food and waterAppendix E. Radiation #12;#12;Annual Site Environmental Report--2011 Appendix E. Radiation E-3

Pennycook, Steve

304

Method for photo-altering a biological system to improve biological effect  

DOE Patents [OSTI]

Photodynamic therapy is a new adjunctive therapy for filtration surgery that does not use chemotherapy agents or radiation, but uses pharmacologically-active sensitizing compounds to produce a titratable, localized, transient, post operative avascular conjunctiva. A photosensitizing agent in a biological system is selectively activated by delivering the photosensitive agent to the biological system and laser activating only a spatially selected portion of the delivered photosensitive agent. The activated portion of the photosensitive agent reacts with the biological system to obtain a predetermined biological effect. As a result, an improved spatial disposition and effectuation of the biological effect by the photosensitive agent in the biological system is achieved.

Hill, Richard A. (Irvine, CA); Doiron, Daniel R. (Santa Ynez, CA); Crean, David H. (Santa Barbara, CA)

2000-08-01T23:59:59.000Z

305

Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION PROTECTION  

Broader source: Energy.gov [DOE]

General. The rules in this part establish radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of DOE activities.

306

A PC-Based Computer Program for the Estimation of the Radiation Dose in in Vitro and in Vivo Boron Neutron Capture Irradiation Experiments  

Science Journals Connector (OSTI)

In Boron Neutron Capture Therapy (BNCT) microdosimetry of charged particle radiation depends on total boron concentration and intracellular boron distribution. Due to the inhomogeneity of boron distribution in...

Ruud Verrijk; Rene Huiskamp; Adrian C. Begg

1993-01-01T23:59:59.000Z

307

Structural biology  

Science Journals Connector (OSTI)

...systematic attempt to 1980 K. C. Holmes Structural biology...structural genomics (Shapiro & Lima 1998). The purpose...Rosenbaum, G., Holmes, K. C. & Witz, J. 1971 Synchrotron...95, 13 585^13590. Shapiro, L. & Lima, C. D. 1998 The Argonne...

1999-01-01T23:59:59.000Z

308

Biological Processes  

Science Journals Connector (OSTI)

Biology is a natural science concerned with the study of living organisms, including their coexistence in the environment. The habitats of humans and other living organisms coincide, and their activities influ...

Dr. Sergey M. Govorushko

2012-01-01T23:59:59.000Z

309

The Departments of Biological Sciences, Chemistry and Economics jointly offer instruction leading to a multidisciplinary major in Agricultural Biotechnology.The program provides background for a  

E-Print Network [OSTI]

to a multidisciplinary major in Agricultural Biotechnology.The program provides background for a diverse range the Coordinator of Agricultural Biotechnology (C876, 380-1813) or the Academic Advising Office (SU060, 329 in the Career Resources Centre (D610; (403) 382-7154) for further information. BachelorofScience AgriculturalBiotechnology

Seldin, Jonathan P.

310

Offsite environmental monitoring report: Radiation monitoring around United States nuclear test areas, calendar year 1993  

SciTech Connect (OSTI)

This report describes the Offsite Radiation Safety Program conducted during 1993 by the Environmental Protection Agency`s (EPA`s) Environmental Monitoring Systems Laboratory - Las Vegas (EMSL-LV). This laboratory operates an environmental radiation monitoring program in the region surrounding the Nevada Test Site (NTS) and at former test sites in Alaska, Colorado, Mississippi, Nevada, and New Mexico. The surveillance program is designed to measure levels and trends of radioactivity, if present, in the environment surrounding testing areas to ascertain whether current radiation levels and associated doses to the general public are in compliance with existing radiation protection standards. The surveillance program additionally has the responsibility to take action to protect the health and well being of the public in the event of any accidental release of radioactive contaminants. Offsite levels of radiation and radioactivity are assessed by sampling milk, water, and air; by deploying thermoluminescent dosimeters (TLDs) and using pressurized ionization chambers (PICs); by biological monitoring of foodstuffs including animal tissues and food crops; and by measurement of radioactive material deposited in humans.

Chaloud, D.J; Daigler, D.M.; Davis, M.G. [and others

1996-06-01T23:59:59.000Z

311

The flying radiation case  

SciTech Connect (OSTI)

The Los Alamos foil implosion program has the goal of producing an intense, high-energy density x-ray source by converting the energy of a magnetically imploded plasma into radiation and material energy. One of the methods for converting the plasma energy into thermal energy and radiation and utilizing it for experiments is called the flying radiation case (FRC). In this paper the authors shall model the FRC and provide a physical description of the processes involved. An analytic model of a planar FRC in the hydrodynamic approximation is used to describe the assembly and shock heating of a central cushion by a conducting liner driver. The results are also used to benchmark a hydrodynamics code for modeling an FRC. They then use a radiation-hydrodynamics computational model to explore the effects of radiation production and transport when a gold plasma assembles on a CH cushion. Results are presented for the structure and evolution of the radiation hohlraum.

Brownell, J.H.; Bowers, R.L. [Los Alamos National Lab., NM (United States). Applied Theoretical and Computational Physics Div.

1997-04-01T23:59:59.000Z

312

Cell type dependent radiation induced signaling and its effect on tissue regulation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Cell type dependent radiation induced signaling and its effect on tissue regulation Cell type dependent radiation induced signaling and its effect on tissue regulation Marianne B. Sowa, Claere von Neubeck, R. Joe Robinson, Paula M. Koehler, Norman J. Karin, Xihai Wang, Katrina M. Waters and Harish Shankaran Ionizing radiation exposure triggers a cell signaling program which includes proliferation, the DNA damage response, and tissue remodeling. The activated signaling pathways lead to the induction of both protective effects as well as adverse consequences. A fundamental question is whether signaling cascades initiated by low doses are fundamentally different than those initiated by high doses. To address this question we have applied a systems biology approach to examine the radiation induced temporal responses of an in vitro three dimensional (3D) human skin tissue model. Using microarray-

313

Alpha Radiation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Basics of Radiation Basics of Radiation Gamma Radiation and X-Rays Beta Radiation Alpha Radiation Irradiation Radioactive Contamination Definitions Detection Measurement Safety Around Radiation Sources Types of Radiation Exposure Managing Radiation Emergencies Basics of Radiation Characteristics of Alpha Radiation 1. Alpha radiation is not able to penetrate skin. 2. Alpha-emitting materials can be harmful to humans if the materials are inhaled, swallowed, or absorbed through open wounds. 3. A variety of instruments have been designed to measure alpha radiation. Special training in use of these instruments is essential for making accurate measurements. 4. A civil defense instrument (CD V-700) cannot detect the presence of radioactive materials that produce alpha radiation unless the radioactive materials also produce beta and/or gamma radiation.

314

Russian Health Studies Program- Program Overview  

Broader source: Energy.gov [DOE]

The Department of Energy's (DOE) Russian Health Studies Program assesses worker and public health risks from radiation exposure resulting from nuclear weapons production activities in the former Soviet Union.

315

Radiation: Radiation Control (Indiana)  

Broader source: Energy.gov [DOE]

It is the policy of the state to encourage the constructive uses of radiation and to control its harmful effects. This section contains regulations pertaining to the manufacture, use,...

316

Biological preconcentrator  

DOE Patents [OSTI]

A biological preconcentrator comprises a stimulus-responsive active film on a stimulus-producing microfabricated platform. The active film can comprise a thermally switchable polymer film that can be used to selectively absorb and desorb proteins from a protein mixture. The biological microfabricated platform can comprise a thin membrane suspended on a substrate with an integral resistive heater and/or thermoelectric cooler for thermal switching of the active polymer film disposed on the membrane. The active polymer film can comprise hydrogel-like polymers, such as poly(ethylene oxide) or poly(n-isopropylacrylamide), that are tethered to the membrane. The biological preconcentrator can be fabricated with semiconductor materials and technologies.

Manginell, Ronald P. (Albuquerque, NM); Bunker, Bruce C. (Albuquerque, NM); Huber, Dale L. (Albuquerque, NM)

2008-09-09T23:59:59.000Z

317

Biology Department - Brookhaven National Laboratory  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

An Outside User Facility at the Biology Department An Outside User Facility at the Biology Department News Releases: Simultaneous Nanoscale Imaging of Surface and Bulk Atoms Details of Bacterial 'Injection' System Revealed Structures of Important Plant Viruses Determined Contacts: Joseph S. Wall James F. Hainfeld Martha N. Simon Frank E. Kito Beth Yu Lin wall@bnl.gov hainfeld@bnl.gov msimon@bnl.gov fkito@bnl.gov bylin@bnl.gov tel: (631) 344-2912 tel: (631) 344-3367 tel: (631) 344-3372 tel: (631) 344-3372 tel: (631) 344-3372 BNL STEM Group (click to enlarge) Biology Department, Bldg 463 Brookhaven National Lab Upton, NY 11973-5000 fax: (631) 344-3407 DOE BER Logo Facility: STEM is a custom-built electron microscope optimized for imaging unstained biological molecules with minimal radiation damage. The group at Brookhaven operates

318

FUNCTIONAL GENOMICS Program of Study  

E-Print Network [OSTI]

FUNCTIONAL GENOMICS Program of Study Research Areas Students Applying Correspondence Graduate Genomics. Students receive training in the biological, physical and computational sciences through of primary institutional affiliation. The Functional Genomics program is administered through the Graduate

Thomas, Andrew

319

Biological Evaluation  

Broader source: Energy.gov (indexed) [DOE]

Biological Evaluation Biological Evaluation for the Proposed United States Army Military Training Activities on the Savannah River Site Department of the Army - Fort Gordon Range Control - Directorate of Plans, Training, Mobilization, and Security Location: Aiken, Allendale, and Barnwell Counties, SC., Savannah River Site Contact Person: Donald S. McLean, 706-840-5522 / 706-791-2422 Submitted by Fort Gordon Range Control Training Facility Coordinator (DPTMS) Prepared By: ___________________________________________________________________ Donald S. McLean, Training Facility Coordinator Fort Gordon Georgia Date: 2 Table of Contents Summary, Page 4 Introduction, Page 6 Project Description, Page 6 Purpose and Need for Proposed Action, Page 7

320

Studies about Space Radiation Promote New Fields in Radiation Biology  

Science Journals Connector (OSTI)

......the ISS will depend on economical conditions. OUR GOAL...Study in the effects of solar ultraviolet light (UV-B...billion years ago by solar ultraviolet light. At...layer. Therefore, the energy from solar UV was stronger than......

Takeo Ohnishi; Akihisa Takahashi; Ken Ohnishi

2002-12-01T23:59:59.000Z

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Radiation Safety  

Broader source: Energy.gov (indexed) [DOE]

Brotherhood of Locomotive Brotherhood of Locomotive Engineers & Trainmen Scott Palmer BLET Radiation Safety Officer New Hire Training New Hire study topics * GCOR * ABTH * SSI * Employee Safety * HazMat * Railroad terminology * OJT * 15-week class * Final test Hazardous Materials * Initial new-hire training * Required by OSHA * No specified class length * Open book test * Triennial module Locomotive Engineer Training A little bit older...a little bit wiser... * Typically 2-4 years' seniority * Pass-or-get-fired promotion * Intensive program * Perpetually tested to a higher standard * 20 Weeks of training * 15 of that is OJT * General Code of Operating Rules * Air Brake & Train Handling * System Special Instructions * Safety Instructions * Federal Regulations * Locomotive Simulators * Test Ride * Pass test with 90% Engineer Recertification

322

Low Dose Radiation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Ancient Salt Beds Ancient Salt Beds Repository Science Renewable Energy The WIPP Underground may be ideal to study effects of Very Low Dose Rates on Biological Systems Low Background Radiation Experiment We're all bathing in it. It's in the food we eat, the water we drink, the soil we tread and even the air we breathe. It's background radiation, it's everywhere and we can't get away from it. But what would happen if you somehow "pulled the plug" on natural background radiation? Would organisms suffer or thrive if they grew up without their constant exposure to background radiation? That's what a consortium of scientists conducting an experiment at the Waste Isolation Pilot Plant aim to find out. Despite being an underground repository for transuranic radioactive waste,

323

Biological clock  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biological clock Biological clock Name: N/A Location: N/A Country: N/A Date: N/A Question: How does a person's biological clock work? Replies: I believe there's a region or gland in the brain that regulates biological clocks. This region or gland senses the environment's day/night cycle. I'm afraid I don't know much more than that. Hope this helps. --- jade No one knows for sure how any circadian (nearly 24 hour-in Latin) clock works. Some interesting facts, though. The pineal gland in the brain is important. Although shifting the day-night cycle can shift the clock, the clock runs on its own without any dark-light cues. So it seems to be a natural chemical clock with a cycle nearly, but not exactly at 24 hours, which is entrained by the 24 hour day-night cycle. There are neurons in lower animals which can be kept alive alone, isolate from the nervous system and from any light-dark cues, that show electrical activity on a near-24-hours cycle

324

An Extract of Phyllanthus amarus Protects Mouse Chromosomes and Intestine from Radiation Induced Damages  

Science Journals Connector (OSTI)

......using Graphpad Instat 3 Software (San Diego, USA...Effect of P.amarus on radiation induced changes in the...Mr. M. Muthuvel, Radiation safety Officer, Amala Cancer...Withers, H. R. (1999) Radiation biology and treatment......

Kuzhuvelil Bhaskaran Nair Harikumar; Ramadasan Kuttan

2007-11-01T23:59:59.000Z

325

Energy deposition and radiation quality of radon and radon daughters. Final report  

SciTech Connect (OSTI)

This program was aimed at creating a quantitative physical description, at the micrometer and nanometer levels, of the physical interactions of the alpha particles from radon and its daughters with cells at risk in the bronchial epithelium. The authors calculated alpha-particle energy spectra incident upon the cells and also energy deposition spectra in micrometer- and nanometer-sized sites as a function of cell depth, site size, airway diameter, activities of {sup 218}Po and {sup 214}Po, and other parameters. These data are now being applied, using biophysical models of radiation effects, to predict cell killing, mutations, and cell transformation. The model predictions are then compared to experimental biophysical, biochemical, and biological information. These studies contribute to a detailed understanding of the mechanisms of the biological effectiveness of the radiations emitted by radon and its progeny.

Karam, L.R.; Caswell, R.S.

1996-09-09T23:59:59.000Z

326

Functional proteomic pattern identification under low dose ionizing radiation  

Science Journals Connector (OSTI)

Objective: High dose radiation has been well known for increasing the risk of carcinogenesis. However, the understanding of biological effects of low dose radiation is limited. Low dose radiation is reported to affect several signaling pathways including ... Keywords: Feature selection, Jumping emerging identification, Low dose radiation, Proteomic signaling patterns

Young Bun Kim; Chin-Rang Yang; Jean Gao

2010-07-01T23:59:59.000Z

327

PNNL: Biological Sciences: Frontiers in Biological Sciences Seminar Series  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Frontiers in Biological Sciences Frontiers in Biological Sciences The seminar series features nationally/internationally known researchers from industry, government, and academia discussing novel ideas and advancements related to biological sciences. The hour-long seminars will feature a 45-minute talk by the featured speaker followed by 15 minutes of discussion with the audience members. 2014 Tim Donohue Timothy J. Donohue, Ph.D. Timothy J. Donohue, Ph.D. Department of Bacteriology University of Wisconsin-Madison Director, Great Lakes Bioenergy Research Center Tuesday, January 14, 2014 EMSL Auditorium 11:00 a.m. Biological Insights and Products Gleaned from Mining Bacterial Genomes and Pathways Professor Donohue has been a member of the UW-Madison Bacteriology Department since 1986. His research program studies bacterial energy

328

Grasshopper Biology  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Grasshopper Biology Grasshopper Biology Name: s. Location: N/A Country: N/A Date: N/A Question: My son found a grasshopper and put it in a fish bowl with cover, and we need to know what to feed it? we have it some lettuce and apple and a bit of water. Replies: Sounds ok so far, most any kind of green plant should be ok, doubt it will pay too much attention to the water. Don't expect it to live very long though. J. Elliott Hello, Grasshoppers eat green vegetation of various kinds. They especially love tall grass. The greener the better. Clip a variety of plants from a nearby unmowed ditch or vacant lot and place them in a short container of water and place the container of water and plants in your fish bowl. The grasshopper will "eat it up". Wayne Vanderploeg River Trail Nature Center

329

User Facility Access Policy | Stanford Synchrotron Radiation Lightsource  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Facility Access Policy Facility Access Policy 1. Summary The Stanford Synchrotron Radiation Lightsource (SSRL) at SLAC National Accelerator Laboratory is a U.S. Department of Energy (DOE) Office of Science national user facility that provides synchrotron radiation to researchers in many fields of science and technology, including biology, catalysis, chemistry, energy, engineering, forensics, geoscience, materials science, medicine, molecular environmental science, and physics. With a pioneering start in 1974, the facility was upgraded to a state-of-the-art third generation lightsource in 2004, providing major improvements in emittance, ring current and new or upgraded beam lines. SSRL's research programs include both the x-ray and ultraviolet regions of the spectrum. SSRL is primarily supported by the DOE Offices of Basic Energy Sciences

330

BIOMEDICAL ENGINEERING CHEMICAL AND BIOLOGICAL ENGINEERING  

E-Print Network [OSTI]

BIOMEDICAL ENGINEERING CHEMICAL AND BIOLOGICAL ENGINEERING CIVIL, ARCHITECTURAL, AND ENVIRONMENTAL Experience. DEPARTMENT OF BIOMEDICAL ENGINEERING · Degree programs in cell and tissue engineering, medical imaging, and neural engineering These are exciting times for biomedical engineering and for Illinois Tech

Heller, Barbara

331

Offsite environmental monitoring report: Radiation monitoring around United States nuclear test areas, calendar year 1991  

SciTech Connect (OSTI)

This report describes the Offsite Radiation Safety Program conducted during 1991 by the Environmental Protection Agency`s (EPA`s) Environmental Monitoring Systems Laboratory-Las Vegas. This laboratory operates an environmental radiation monitoring program in the region surrounding the Nevada Test Site (NTS) and at former test sites in Alaska, Colorado, Mississippi, Nevada, and New Mexico. The surveillance program is designed to measure levels and trends of radioactivity, if present, in the environment surrounding testing areas to ascertain whether current radiation levels and associated doses to the general public are in compliance with existing radiation protection standards. The surveillance program additionally has the responsibility to take action to protect the health and well being of the public in the event of any accidental release of radioactive contaminants. Offsite levels of radiation and radioactivity are assessed by sampling milk, water, and air; by deploying thermoluminescent dosimeters (TLDs) and using pressurized ion chambers (PICs); and by biological monitoring of animals, food crops, and humans. Personnel with mobile monitoring equipment are placed in areas downwind from the test site prior to each nuclear weapons test to implement protective actions, provide immediate radiation monitoring, and obtain environmental samples rapidly after any occurrence of radioactivity release. Comparison of the measurements and sample analysis results with background levels and with appropriate standards and regulations indicated that there was no radioactivity detected offsite by the various EPA monitoring networks and no exposure above natural background to the population living in the vicinity of the NTS that could be attributed to current NTS activities. Annual and long-term trends were evaluated in the Noble Gas, Tritium, Milk Surveillance, Biomonitoring, TLD, PIC networks, and the Long-Term Hydrological Monitoring Program.

Chaloud, D.J.; Dicey, B.B.; Mullen, A.A.; Neale, A.C.; Sparks, A.R.; Fontana, C.A.; Carroll, L.D.; Phillips, W.G.; Smith, D.D.; Thome, D.J.

1992-01-01T23:59:59.000Z

332

Russian Health Studies Program  

Broader source: Energy.gov [DOE]

The Department of Energy's (DOE) Russian Health Studies Program assesses worker and public health risks from radiation exposure resulting from nuclear weapons production activities in the former Soviet Union.

333

Safety Around Sources of Radiation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Keeping Exposure Low Keeping Exposure Low Working Safely Around Radioactive Contamination Types of Radiation Exposure Managing Radiation Emergencies Procedure Demonstration Is it safe to be around sources? Too much radiation exposure is harmful. The degree of radiation injury depends on the amount of radiation received and the time involved. In general, the higher the amount, the greater the severity of early effects (occurring within a few weeks) and the greater the possibility of late effects such as cancer. The BEIR V (Biological Effects of Ionizing Radiation) Committee of the National Research Council estimates that among 100,000 people exposed to a one-time dose of 10 rem (10,000 mrem) and followed over their life span, about 790 more would die of cancer than the estimated 20,000 cancer deaths that would be expected among a non-exposed group of the same size. NOTE: 10 rem = 100 millisieverts (100 mSv).

334

The Hydrogen Program at NREL: A Brief Overview  

Broader source: Energy.gov (indexed) [DOE]

Laboratory Program Manager Richard V. Greene, Biosciences Center Director Biological Hydrogen Production Workshop September 24, 2013 The Hydrogen Program at NREL: A Brief Overview...

335

Psoriasis and ultraviolet radiation  

SciTech Connect (OSTI)

Prevention and detection screening programs as a public health service in curtailing the ever-increasing incidence of all forms of skin cancer are reviewed. The effect of solar and artificial ultraviolet radiation on the general population and persons with psoriasis is examined. 54 refs.

Farber, E.M.; Nall, L. (Psoriasis Research Institute, Palo Alto, CA (United States))

1993-09-01T23:59:59.000Z

336

The Biology of You  

E-Print Network [OSTI]

Merced majoring in Human Biology with a minor in Creativeschool in the future. the biology of you 137 UC Merced

Inneh, Joy

2013-01-01T23:59:59.000Z

337

Environment/Health/Safety (EHS): Radiation Protection Group: Radiation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Who To Call Who To Call Rad Training Dosimetry Telemetry Laser Safety Radiation Safety Committee Pub-3000 Ch. 21 Forms RPG Procedures RPG Internal Radiation Safety Committee Charter Purpose The Berkeley Lab Radiation Safety Committee (RSC) is appointed by, and reports to, the Laboratory Director and is responsible for advising LBNL Management on all matters related to occupational and environmental radiation safety. The Radiation Safety Committee reviews and recommends approval of radiation safety policies and guides the Environment, Health and Safety Division and radiation user divisions in carrying out these programs. The scope of its actions will generally be in issues of broad institutional concern and impact, or areas of potential high consequence either in terms of safety or institutional needs.

338

Biological Science  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biological Science Biological Science A unique zinc-binding site revealed by the high-resolution x-ray structure of homotrimeric Apo2L/TRAIL S.G. Hymowitz, M.P. O'Connell, M.H. Ultsch, A. Hurst, K. Totpal, A. Ashkenazi, R.F. Kelley, and A.M. de Vos b-carbonic anhydrase active site architecture is a mirror image of a-carbonic anhydrases E.F. Pai and M.S. Kimber Binding of Cd ions to the cell wall of B. Subtilis - an EXAFS study M. Boyanov, D. Fowle, K. Kemner, B. Bunker, and J. Fein Crystallographic evidence for Try157 functioning as the active site base in human UDP-galactose 4-epimerase J.B. Thoden, T.M. Wohlers, J.L. Fridovich-Keil, and H.M. Holden Crystallographic studies of dsDNA phage HK97 structure and maturation W.R. Wikoff, Z. Che, W. Schildkamp, L. Liljas, R.L. Duda, R.W. Hendrix, and

339

About Radiation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Radiation Radiation What is radiation? Radiation is a form of energy that is a part of our everyday lives. All of us receive a "dose" of radiation each day. Most of the dose comes from naturally occurring radioactive materials such as uranium, thorium, radon, and certain forms of potassium and carbon. The air we breathe contains radon, the food we eat contains uranium and thorium from the soil, and our bodies contain radioactive forms of potassium and carbon. Cosmic radiation from the sun also contributes to our natural radiation dose. We also receive radiation doses from man-made sources such as X-rays, nuclear medical procedures, power plants, smoke detectors and older television sets. Some people, such as nuclear plant operators, flight crews, and nuclear medicine staff may also receive an occupational radiation dose.

340

April 2013 Most Viewed Documents for Biology And Medicine | OSTI, US Dept  

Office of Scientific and Technical Information (OSTI)

April 2013 Most Viewed Documents for Biology And Medicine April 2013 Most Viewed Documents for Biology And Medicine Publications in biomedical and environmental sciences programs, 1981 Moody, J.B. (comp.) (1982) 306 Drug Retention Times Center for Human Reliability Studies (2007) 99 SURVEY OF NOISE SUPPRESSION SYSTEMS FOR ENGINE GENERATOR SETS. KRISHNA,C.R. (1999) 95 Defining the Effectiveness of UV Lamps Installed in Circulating Air Ductwork Douglas VanOsdell; Karin Foarde (2002) 84 Mesoporous Silica Nanomaterials for Applications in Catalysis, Sensing, Drug Delivery and Gene Transfection Daniela Rodica Radu (2005) 84 Advisory Committee on human radiation experiments. Supplemental Volume 2a, Sources and documentation appendices. Final report NONE (1995) 72 Dose and volume specification for reporting interstitial therapy

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Danger radiations  

ScienceCinema (OSTI)

Le confrencier Mons.Hofert parle des dangers et risques des radiations, le contrle des zones et les prcautions prendre ( p.ex. film badge), comment mesurer les radiations etc.

None

2011-04-25T23:59:59.000Z

342

DOE contractors' workshop: Cellular and molecular aspects of radiation induced DNA damage and repair  

SciTech Connect (OSTI)

For four decades the US Department of Energy and its predecessors have been the lead federal agency in supporting radiation biology research. Over the years emphasis in this program has gradually shifted from dose-effect studies on animals to research on the effects of radiations of various qualities on cells and molecules. Mechanistic studies on the action of radiation at the subcellular level are few in number and there is a need for more research in this area if we are to gain a better understanding of how radiation affects living cells. The intent of this workshop was to bring together DOE contractors and grantees who are investigating the effects of radiation at the cellular and molecular levels. The aims were to foster the exchange of information on research projects and experimental results, promote collaborative research efforts, and obtain an overview of research currently supported by the Health Effects Research Division of the Office of Health and Environmental Research. The latter is needed by the Office for program planning purposes. This report on the workshop which took place in Albuquerque, New Mexico on March 10-11, 1987, includes an overview with future research recommendations, extended abstracts of the plenary presentations, shorter abstracts of each poster presentation, a workshop agenda and the names and addresses of the attendees.

Not Available

1987-01-01T23:59:59.000Z

343

Radiation Emergency Medicine Fact Sheet  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Improving Global Response Improving Global Response to Radiation Emergencies Improving Radiation Emergency Response Through Education and Specialized Expertise In the event of a radiological or nuclear incident, first responders as well as hospital and emergency management personnel must call on their knowledge and training to provide immediate and effective care for victims. Through practical, hands-on education programs, Oak Ridge Associated Universities (ORAU) is improving global response to radiation emergencies. In addition, dedicated 24/7 deployable teams of physicians, nurses, and health physicists from the Radiation Emergency Assistance Center/Training Site (REAC/TS), which is managed by ORAU for DOE/NNSA, provide expert medical management of radiological incidents

344

Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION PROTECTION Subpart A- General Provisions  

Broader source: Energy.gov [DOE]

The rules in this part establish radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of DOE activities.

345

Atmospheric Radiation Measurement Climate Research Facility (ACRF) Annual Report 2007  

SciTech Connect (OSTI)

This annual report describes the purpose and structure of the program, and presents key accomplishments in 2007. Notable achievements include: Successful review of the ACRF as a user facility by the DOE Biological and Environmental Research Advisory Committee. The subcommittee reinforced the importance of the scientific impacts of this facility, and its value for the international research community. Leadership of the Cloud Land Surface Interaction Campaign. This multi-agency, interdisciplinary field campaign involved enhanced surface instrumentation at the ACRF Southern Great Plains site and, in concert with the Cumulus Humilis Aerosol Processing Study sponsored by the DOE Atmospheric Science Program, coordination of nine aircraft through the ARM Aerial Vehicles Program. Successful deployment of the ARM Mobile Facility in Germany, including hosting nearly a dozen guest instruments and drawing almost 5000 visitors to the site. Key advancements in the representation of radiative transfer in weather forecast models from the European Centre for Medium-Range Weather Forecasts. Development of several new enhanced data sets, ranging from best estimate surface radiation measurements from multiple sensors at all ACRF sites to the extension of time-height cloud occurrence profiles to Niamey, Niger, Africa. Publication of three research papers in a single issue (February 2007) of the Bulletin of the American Meteorological Society.

LR Roeder

2007-12-01T23:59:59.000Z

346

Russian Health Studies Program - Joint Coordinating Committee...  

Broader source: Energy.gov (indexed) [DOE]

and Security in the United States and the Federal Medical Biological Agency (FMBA) in Russia. The program is administered by DOE's Office of Domestic and International Health...

347

Neutron Scattering User Program | Neutron Science | ORNL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

User Program SHARE Neutron Scattering Can Benefit Your Research Neutron scattering has applications in almost every technical and scientific field, from biology and chemistry to...

348

Radiation Management Act (Oklahoma) | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Radiation Management Act (Oklahoma) Radiation Management Act (Oklahoma) Radiation Management Act (Oklahoma) < Back Eligibility Utility Investor-Owned Utility Program Info State Oklahoma Program Type Environmental Regulations Provider Oklahoma Department of Environmental Quality This Act establishes The Department of Environmental Quality as the designated official agency of the State of Oklahoma for all regulatory activities for the use of atomic energy and sources of radiation, except for the use of sources of radiation by diagnostic x-ray facilities. It also states rules for permits and fees related to the establishment of standards for safe levels of protection against radiation; the maintenance and submission of records; the determination, prevention and control of radiation hazards; the reporting of radiation accidents; the handling,

349

A Synthetic Biology Framework for Programming Eukaryotic  

E-Print Network [OSTI]

coactivator/repressor complexes and basal transcriptional machinery, cooperating with other TFs to regulate of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA engineer complex functions, such as tunable output strength and transcriptional cooperativity

Khalil, Ahmad S.

350

Graduate Programs Handbook Department of Horticulture Graduate Handbook  

E-Print Network [OSTI]

Research Involving Radiation, Chemicals, or Biological Agents Research Involving Travel or Transportation.D. Comprehensive Examination Ph.D. Oral Comprehensive Exam - Moderator's Guidelines Preparation of the Doctoral

351

Topics in radiation at accelerators: Radiation physics for personnel and environmental protection  

SciTech Connect (OSTI)

In the first chapter, terminology, physical and radiological quantities, and units of measurement used to describe the properties of accelerator radiation fields are reviewed. The general considerations of primary radiation fields pertinent to accelerators are discussed. The primary radiation fields produced by electron beams are described qualitatively and quantitatively. In the same manner the primary radiation fields produced by proton and ion beams are described. Subsequent chapters describe: shielding of electrons and photons at accelerators; shielding of proton and ion accelerators; low energy prompt radiation phenomena; induced radioactivity at accelerators; topics in radiation protection instrumentation at accelerators; and accelerator radiation protection program elements.

Cossairt, J.D.

1996-10-01T23:59:59.000Z

352

Sorghum Program BIOENERGY PROGRAM  

E-Print Network [OSTI]

Sorghum Program BIOENERGY PROGRAM Sorghums are important nongrain lignocellulosic feedstocks Biomass Switch Grass Forage Sorghum Bioenergy Sorghum Biomass per acre per year that can be converted (DT

353

Radiation monitoring around United States nuclear test areas, calendar year 1989  

SciTech Connect (OSTI)

This report describes the Offsite Radiation Safety Program conducted during 1989 by the Environmental Protection Agency's (EPA's) Environmental Monitoring Systems Laboratory-Las Vegas (EMSL-LV). This laboratory operates an environmental radiation monitoring program in the region surrounding the Nevada Test Site (NTS) and at former test sites in Alaska, Colorado, Mississippi, Nevada, and New Mexico. The surveillance program is designed to measure levels, and trends of radioactivity, if present, in the environment surrounding testing areas to ascertain whether the testing is in compliance with existing radiation protection standards, and to take action to protect the health and well being of the public in the event of any accidental release of radioactive contaminants. Offsite levels of radiation and radioactivity are assessed by sampling milk, water, and air; by deploying thermoluminescent dosimeters (TLDs) and using pressurized ion chambers (PICs); and by biological monitoring of both animals and humans. To implement protective actions, provide immediate radiation monitoring, and obtain environmental samples rapidly after any release of radioactivity, personnel with mobile monitoring equipment are placed in areas downwind from the test site prior to each test. Comparison of the measurements and sample analysis results with background levels and with appropriate standards and regulations indicated that there was no radioactivity detected offsite by the various EPA monitoring networks and no exposure above natural background to the population living in the vicinity of the NTS that could be attributed to NTS activities. Trends were evaluated in the Noble Gas and Tritium, Milk Surveillance, TLD, and PIC networks, and the Long-Term Hydrological Monitoring Program. 35 refs., 68 figs., 32 tabs.

Not Available

1990-05-01T23:59:59.000Z

354

Computational Biology: A Strategic Initiative LDRD  

SciTech Connect (OSTI)

The goal of this Strategic Initiative LDRD project was to establish at LLNL a new core capability in computational biology, combining laboratory strengths in high performance computing, molecular biology, and computational chemistry and physics. As described in this report, this project has been very successful in achieving this goal. This success is demonstrated by the large number of referred publications, invited talks, and follow-on research grants that have resulted from this project. Additionally, this project has helped build connections to internal and external collaborators and funding agencies that will be critical to the long-term vitality of LLNL programs in computational biology. Most importantly, this project has helped establish on-going research groups in the Biology and Biotechnology Research Program, the Physics and Applied Technology Directorate, and the Computation Directorate. These groups include three laboratory staff members originally hired as post-doctoral researchers for this strategic initiative.

Barksy, D; Colvin, M

2002-02-07T23:59:59.000Z

355

Light propagation in biological tissues containing an absorbing plate  

E-Print Network [OSTI]

in the forward direction, we replace the governing radiative transport equation with the Fokker­ Planck equation. Introduction Light propagation in biological tissue is governed by the radiative transport equation.1 approxima- tion to the transport equation.3­8 However, these results are limited by the fact

Kim, Arnold D.

356

Safeguards and Security Program - DOE Directives, Delegations...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

1 Chg 1, Safeguards and Security Program by Website Administrator Functional areas: Environment, Safety, and Health, Hazardous Materials, Radiation Protection, Safeguards,...

357

BIOMEDICAL SCIENCES Program of Study  

E-Print Network [OSTI]

BIOMEDICAL SCIENCES Program of Study Applying Correspondence Graduate Faculty The Graduate School of Biomedical Sciences (GSBS) offers a doctoral degree in Biomedical Sciences with concentrations in: Molecular and Cellular Biology Neuroscience Biomedical Engineering Toxicology as well as an interdisciplinary doctoral

Thomas, Andrew

358

Radiation Dose Is More Than A Number Workshop 15-16 September 2011  

E-Print Network [OSTI]

or Water Contamination Nuclear detonation Accident ­ Power Plant Release ­ Sealed radiological sources.D. Associate Director, Radiation/Nuclear Countermeasures Program Division of Allergy, Immunology #12;NIAID Radiation/Nuclear Medical Countermeasures Development Program HHS assigned NIH

359

Pamphlet, A Basic Overview of Occupational Radiation Exposure Monitoring, Analysis & Reporting  

Broader source: Energy.gov [DOE]

This pamphlet is intended to provide a short summary of two specific HSS programs that aid in the oversight of radiation protection activities at DOE, Department of Energy Laboratory Accreditation Program (DOELAP) and Radiation Exposure Monitoring Systems (REMS)

360

Plasma Radiation  

Science Journals Connector (OSTI)

... JUST over ten years ago the first book on plasma physics as a subject in its own right appeared; in a gradually swelling stream ... been surprisingly few monographs. One topic which has had scant coverage in any form is plasma radiation (except for spectral-line radiation which has been dealt with very fully in ...

T. J. M. BOYD

1967-07-01T23:59:59.000Z

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Integrated Science Faculty in the College of Science Nanoscience, Neuroscience, Systems Biology, and  

E-Print Network [OSTI]

Integrated Science Faculty in the College of Science Nanoscience, Neuroscience, Systems Biology, and Computational Science !As part of Virginia Tech's expanding presence in emerging interdisciplinary programs and degrees in nanoscience, neuroscience, systems biology, and computational science, the College of Science

Virginia Tech

362

Radiation dosimeter  

DOE Patents [OSTI]

A radiation detector readout circuit is provided which produces a radiation dose-rate readout from a detector even though the detector output may be highly energy dependent. A linear charge amplifier including an output charge pump circuit amplifies the charge signal pulses from the detector and pumps the charge into a charge storage capacitor. The discharge rate of the capacitor through a resistor is controlled to provide a time-dependent voltage which when integrated provides an output proportional to the dose-rate of radiation detected by the detector. This output may be converted to digital form for readout on a digital display.

Fox, Richard J. (Oak Ridge, TN)

1983-01-01T23:59:59.000Z

363

Radiation dosimeter  

DOE Patents [OSTI]

A radiation detector readout circuit is provided which produces a radiation dose-rate readout from a detector even through the detector output may be highly energy dependent. A linear charge amplifier including an output charge pump circuit amplifies the charge signal pulses from the detector and pumps the charge into a charge storage capacitor. The discharge rate of the capacitor through a resistor is controlled to provide a time-dependent voltage which when integrated provides an output proportional to the dose-rate of radiation detected by the detector. This output may be converted to digital form for readout on a digital display.

Fox, R.J.

1981-09-01T23:59:59.000Z

364

Radiation Damage in Titanate Ceramics Used for Plutonium Immobilization  

SciTech Connect (OSTI)

Results from radiation damage experiments are discussed with respect to the immobilization of Pu declared excess to the weapons programs. The ceramics are titanate-based.

Strachan, Denis M.; Scheele, Randall D.; Kozelisky, Anne E.; Sell, Richard L.; Schaef, Herbert T.; O'Hara, Matthew J.; Brown, Christopher F.; Buchmiller, William C.

2002-05-01T23:59:59.000Z

365

Experiment generates THz radiation 20,000 times brighter than...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Gwyn Williams Gwyn Williams, JLab's FEL Basic Research Program manager, led a multi-lab experiment that generated nearly 20 watts of terahertz radiation - a world record....

366

Distribution of Radiation Density in a Homogeneous Cloudy Laye  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

A. M. Obukhov Institute of Atmospheric Physics Russian Academy of Sciences Moscow, Russia The program block (Monte-Carlo method) allowing calculating radiation density in...

367

A Basic Overview of Occupational Radiation Exposure Monitoring, Analysis & Reporting  

Broader source: Energy.gov [DOE]

This pamphlet is intended to provide a short summary of the Department of Energy Laboratory Accreditation Program and DOE Radiation Exposure Monitoring

368

A Basic Overview of the Occupational Radiation Exposure Monitoring...  

Office of Environmental Management (EM)

and accurate, and conforms to national and international performance and quality assurance standards. The DOE Radiation Exposure Monitoring Systems (REMS) program provides for...

369

TWO-DIMENSIONAL TRANSIENT RADIATIVE HEAT TRANSFER USING DISCRETE ORDINATES METHOD  

E-Print Network [OSTI]

transport is time-dependent radiative transfer equation. The solution of the hyperbolic transient radiative-pulsed laser radiation interaction and transport within biological tissues. INTRODUCTION With the advent of the short-pulsed laser with the duration of the order of femtoseconds, transient laser radiation transport

Guo, Zhixiong "James"

370

RADIATION RESEARCH 155, 397401 (2001) 0033-7587/01 $5.00  

E-Print Network [OSTI]

for risk estimation for low-dose radiation. 2001 by Radiation Research Society INTRODUCTION It has been to low doses of particles, biological effects occur in a larger proportion of cells than are estimated397 RADIATION RESEARCH 155, 397­401 (2001) 0033-7587/01 $5.00 2001 by Radiation Research Society

371

Appendix E. Radiation Oak Ridge Reservation Annual Site Environmental Report--2012  

E-Print Network [OSTI]

. People are exposed to naturally occurring radiation constantly. For example, cosmic radiation; radon effects on the environment and biological systems. Radiation comes from natural and human-made sourcesAppendix E. Radiation #12;#12;Oak Ridge Reservation Annual Site Environmental Report--2012 Appendix

Pennycook, Steve

372

Appendix E. Radiation Oak Ridge Reservation Annual Site Environmental Report--2013  

E-Print Network [OSTI]

. People are exposed to naturally occurring radiation constantly. For example, cosmic radiation; radon effects on the environment and biological systems. Radiation comes from natural and human-made sourcesAppendix E. Radiation #12;#12;Oak Ridge Reservation Annual Site Environmental Report--2013 Appendix

Pennycook, Steve

373

FAQS Qualification Card - Radiation Protection | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Radiation Protection Radiation Protection FAQS Qualification Card - Radiation Protection A key element for the Department's Technical Qualification Programs is a set of common Functional Area Qualification Standards (FAQS) and associated Job Task Analyses (JTA). These standards are developed for various functional areas of responsibility in the Department, including oversight of safety management programs identified as hazard controls in Documented Safety Analyses (DSA). For each functional area, the FAQS identify the minimum technical competencies and supporting knowledge and skills for a typical qualified individual working in the area. FAQC-RadiationProtection.docx Description Radiation Protection Qualification Card More Documents & Publications FAQS Gap Analysis Qualification Card - Radiation Protection

374

Biological Sciences at NERSC  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biological Sciences Biological Sciences Biological Sciences Better knowledge of biomolecules and processes they undergo is vital for achieving a predictive, systems-level understanding of complex biological systems that have potential use in bioenergy, carbon cycling and biosequestration, and biogeochemistry. Areas that NERSC helps to enable include: Research activities using genomics and systems biology to understand plants and microbes. Developing and applying atomistic-molecular to coarse-grained mathematical models of potential energy surfaces, characterizing these surfaces through sampling techniques and finally generating ensemble or time averaged physical properties of biological phenomena. Fundamental research in the redesign of microbial metabolic processes to harness their potential in the conversion of biomass to

375

E-Print Network 3.0 - asthma education program Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

National Institutes of Health Collection: Biology and Medicine 2 About the Air Pollution and Respiratory Health Program The Air Pollution and Respiratory Health Program of...

376

Determination of erythema-effective solar radiation in Japan and Germany with a spore monolayer film optimized for the detection of UVB and UVA results of a field campaign  

Science Journals Connector (OSTI)

...The available physical and biological broadband radiometers designed to determine erythema-effective radiation do not show any response or over/underestimate the biologically effective radiation to a high exte...

Y. Furusawa; L. E. Quintern; H. Holtschmidt

1998-11-01T23:59:59.000Z

377

E-Print Network 3.0 - aerosol program program Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

CHAPSCLASIC Summary: Observations of Cloud-Aerosol Halos During CHAPSCLASIC Funded by NASA HQ Science Mission... Directorate Radiation Sciences Program Funded by Department of...

378

Structural Molecular Biology, SSRL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biological Small Angle X-ray Scattering Workshop The SSRL Structural Molecular Biology Group hosted a 3-day comprehensive workshop on the use of non-crystalline small-angle...

379

Engineering scalable biological systems  

E-Print Network [OSTI]

Synthetic biology is focused on engineering biological organisms to study natural systems and to provide new solutions for pressing medical, industrial, and environmental problems. At the core of engineered organisms are ...

Lu, Timothy K.

380

radiation detection  

National Nuclear Security Administration (NNSA)

for the system's sustainability through operations and maintenance training, and "train-the-trainer" activities.

NNSA's SLD program works to strengthen the capabilities...

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

E-Print Network 3.0 - augmentative biological control Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of Chicago, Sensory Motor Performance Program (SMPP) Collection: Biology and Medicine ; Engineering 89 Digital Creativity 2006, Vol. 17, No. 1, pp. 3648 Summary: ) Augmented...

382

Biological Water Gas Shift DOE Hydrogen, Fuel Cell, and Infrastructure  

E-Print Network [OSTI]

Biological Water Gas Shift DOE Hydrogen, Fuel Cell, and Infrastructure Technologies Program Review was produced from water in a linked cyanobacterial- hydrogenase hybrid system Isolated mutants and cloned 2

383

Optical techniques for detecting and identifying biological-warfare agents  

E-Print Network [OSTI]

Rapid and accurate detection and identification of biological agents is an objective of various national security programs. Detection in general is difficult owing to natural clutter and anticipated low concentrations of ...

Greenwood, Darryl P.

384

Systems biology approach to bioremediation  

E-Print Network [OSTI]

aspects of the systems biology approach (metagenomics withthe use of a number of sytems biology parameters can revealRL, Banfield JF: Systems Biology: functional analysis of

Chakraborty, R.

2013-01-01T23:59:59.000Z

385

Careers with Forensic Biology  

E-Print Network [OSTI]

Careers with Forensic Biology www.twitter.com/mmu_careers www.facebook.com/MMUCareersandEmployability Careers & Employability Service www.mmu.ac.uk/careers/guides #12;2 08/12 Careers with Forensic Biology These are a range of careers and employers that would use and value your forensic biology knowledge: Laboratory

386

Graduate Student Handbook Cell, Molecular, Developmental Biology and  

E-Print Network [OSTI]

Graduate Student Handbook Cell, Molecular, Developmental Biology and Biophysics Graduate Program The Johns Hopkins University Baltimore, MD This handbook is subject to change and corrections. September 1, and developmental biology and genetics. The core curriculum covers the fundamentals in each area at a rigorous

von der Heydt, Rüdiger

387

SynFlo: an interactive installation introducing synthetic biology concepts  

Science Journals Connector (OSTI)

SynFlo is an interactive installation that utilizes tangible interaction to help illustrate core concepts of synthetic biology through outreach programs. This playful installation allows users to create useful virtual life forms from standardized genetic ... Keywords: E. chromi, microsoft surface, sifteo cubes, synthetic biology, tangible user interfaces

Kimberly Chang; Wendy Xu; Nicole Francisco; Consuelo Valdes; Robert Kincaid; Orit Shaer

2012-11-01T23:59:59.000Z

388

Radiation receiver  

DOE Patents [OSTI]

The apparatus for collecting radiant energy and converting same to alternate energy form includes a housing having an interior space and a radiation transparent window allowing, for example, solar radiation to be received in the interior space of the housing. Means are provided for passing a stream of fluid past said window and for injecting radiation absorbent particles in said fluid stream. The particles absorb the radiation and because of their very large surface area, quickly release the heat to the surrounding fluid stream. The fluid stream particle mixture is heated until the particles vaporize. The fluid stream is then allowed to expand in, for example, a gas turbine to produce mechanical energy. In an aspect of the present invention properly sized particles need not be vaporized prior to the entrance of the fluid stream into the turbine, as the particles will not damage the turbine blades. In yet another aspect of the invention, conventional fuel injectors are provided to inject fuel into the fluid stream to maintain the proper temperature and pressure of the fluid stream should the source of radiant energy be interrupted. In yet another aspect of the invention, an apparatus is provided which includes means for providing a hot fluid stream having hot particles disbursed therein which can radiate energy, means for providing a cooler fluid stream having cooler particles disbursed therein, which particles can absorb radiant energy and means for passing the hot fluid stream adjacent the cooler fluid stream to warm the cooler fluid and cooler particles by the radiation from the hot fluid and hot particles. 5 figs.

Hunt, A.J.

1983-09-13T23:59:59.000Z

389

Molecular Mechanism Underlying Cellular Adaptive Response to Low Dose Radiation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mechanism Underlying Cellular Adaptive Response to Low Dose Radiation Mechanism Underlying Cellular Adaptive Response to Low Dose Radiation Colette A. Sacksteder § , DJ Black ‡ , Heather Smallwood § , David G. Camp II † , and Thomas C. Squier § § Cell Biology and Biochemistry; † Biological Sciences Division Pacific Northwest National Laboratory, Richland WA 99352 ‡ School of Biological Sciences, University of Missouri, Kansas City MO 64110 The goal of this research is to identify the molecular mechanisms by which cells adapt to low dose radiation exposure. Previously we have shown a radiation dependent increase of Calmodulin (CaM) in RAW 264.7 macrophages (RAW). Therefore we hypothesize that CaM and associated signaling complexes are sensors of low-dose radiation, resulting in alterations in energy metabolism and gene expression. The ultimate experimental goal

390

Biological constraints on habitability  

Science Journals Connector (OSTI)

......the high concentration of dissolved salts as the surrounding seawater freezes, and thin films of water remain fluid around mineral...standard laboratory procedure for preserving microbial samples for storage. Radiation Radiation that affects the survival of organisms......

Lewis Dartnell

2011-02-01T23:59:59.000Z

391

Use of EORTC Target Definition Guidelines for Dose-Intensified Salvage Radiation Therapy for Recurrent Prostate Cancer: Results of the Quality Assurance Program of the Randomized Trial SAKK 09/10  

SciTech Connect (OSTI)

Purpose: Different international target volume delineation guidelines exist and different treatment techniques are available for salvage radiation therapy (RT) for recurrent prostate cancer, but less is known regarding their respective applicability in clinical practice. Methods and Materials: A randomized phase III trial testing 64 Gy vs 70 Gy salvage RT was accompanied by an intense quality assurance program including a site-specific and study-specific questionnaire and a dummy run (DR). Target volume delineation was performed according to the European Organisation for the Research and Treatment of Cancer guidelines, and a DR-based treatment plan was established for 70 Gy. Major and minor protocol deviations were noted, interobserver agreement of delineated target contours was assessed, and dose-volume histogram (DVH) parameters of different treatment techniques were compared. Results: Thirty European centers participated, 43% of which were using 3-dimensional conformal RT (3D-CRT), with the remaining centers using intensity modulated RT (IMRT) or volumetric modulated arc technique (VMAT). The first submitted version of the DR contained major deviations in 21 of 30 (70%) centers, mostly caused by inappropriately defined or lack of prostate bed (PB). All but 5 centers completed the DR successfully with their second submitted version. The interobserver agreement of the PB was moderate and was improved by the DR review, as indicated by an increased ? value (0.59 vs 0.55), mean sensitivity (0.64 vs 0.58), volume of total agreement (3.9 vs 3.3 cm{sup 3}), and decrease in the union volume (79.3 vs 84.2 cm{sup 3}). Rectal and bladder wall DVH parameters of IMRT and VMAT vs 3D-CRT plans were not significantly different. Conclusions: The interobserver agreement of PB delineation was moderate but was improved by the DR. Major deviations could be identified for the majority of centers. The DR has improved the acquaintance of the participating centers with the trial protocol.

Sassowsky, Manfred [Department of Radiation Oncology and Division of Medical Radiation Physics, Bern University Hospital (Switzerland); Gut, Philipp [Department of Radiation Oncology Kantonsspital Luzern (Switzerland); Hlscher, Tobias [University Hospital Dresden (Germany); Hildebrandt, Guido [University Hospital Rostock (Germany); Mller, Arndt-Christian [University Hospital Tbingen (Germany); Najafi, Yousef [University Hospital Zrich (Switzerland); Kohler, Gtz [University Hospital Basel (Switzerland); Kranzbhler, Helmut [Stadtspital Triemli, Zrich (Switzerland); Guckenberger, Matthias [University Hospital Wrzburg (Germany); Zwahlen, Daniel R. [Kantonsspital Graubnden, Chur (Switzerland); Azinwi, Ngwa C. [Istituto Oncologico della Svizzera Italiana, Bellinzona (Switzerland); Plasswilm, Ludwig [Kantonsspital St. Gallen (Switzerland); Takacs, Istvan [Kantonsspital Aarau (Switzerland); Reuter, Christiane [Kantonsspital Mnsterlingen (Switzerland); Sumila, Marcin [Hirslanden Hospital Group, Zrich (Switzerland); Manser, Peter [Department of Radiation Oncology and Division of Medical Radiation Physics, Bern University Hospital (Switzerland); Ost, Piet [Ghent University Hospital (Belgium); Bhmer, Dirk [Charit University Medicine, Berlin (Germany); Pilop, Christiane [Swiss Group for Clinical Cancer Research, Coordinating Center, Bern (Switzerland); Aebersold, Daniel M. [Department of Radiation Oncology and Division of Medical Radiation Physics, Bern University Hospital (Switzerland); and others

2013-11-01T23:59:59.000Z

392

Radiation (North Dakota) | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Radiation (North Dakota) Radiation (North Dakota) Radiation (North Dakota) < Back Eligibility Utility Fed. Government Commercial Agricultural Investor-Owned Utility State/Provincial Govt Industrial Construction Municipal/Public Utility Local Government Residential Installer/Contractor Rural Electric Cooperative Tribal Government Low-Income Residential Schools Retail Supplier Institutional Multi-Family Residential Systems Integrator Fuel Distributor Nonprofit General Public/Consumer Transportation Program Info State North Dakota Program Type Environmental Regulations The Department of Health is the designated agency to receive registration applications and issue certificates necessary for the production, storage, processing, and disposal of radioactive wastes. The Industrial Commission of North Dakota is tasked with monitoring and enforcing provisions related

393

BNL/NASA Radiobiology Program  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

General General Radiobiology Home AGS Description NSRL Description NSRL Images NASA Space Radiation Summer School NSRL Beam Info NSRL Users Beamline Requests Steps to Complete Prior to Your Experiment First Time Users Guide Related Links Biosciences Dept. Collider-Accelerator Dept. RHIC/AGS User Center NASA Space Research NASA-USRA Space Radiation Program Space Radiobiology A Collaborative Project sponsored by the NASA Space Radiation Program Manned space exploration in the 21st century holds exciting prospects for the advancement of science and the expansion of the human experience. Plans include the Alpha space station, an outpost on the Moon, exploration of near asteroids, and a piloted mission to Mars. However, for space exploration to go on, human crew members must be protected against the harsh environment of space, in particular, against the hazards of ionizing radiation. The radiation environment in space consists of high energy protons and high energy heavy ions (HZE).

394

Radiation Research Department Paper: www.risoe.dk/rispubl/art/2007_333.pdf  

E-Print Network [OSTI]

and released to the environment by human nuclear activity, including nuclear weapons testing, operation of Radionuclides in Environmental, Biological and Nuclear Waste Samples Xiaolin Hou and Per Roos Radiation Research in Environmental, Biological and Nuclear Waste Samples Xiaolin Hou* Per Roos Radiation Research Department, Risø

395

Biological and chemical technologies research. FY 1995 annual summary report  

SciTech Connect (OSTI)

The annual summary report presents the fiscal year (FY) 1995 research activities and accomplishments for the United States Department of Energy (DOE) Biological and Chemical Technologies Research (BCTR) Program. This BCTR program resides within the Office of Industrial Technologies (OIT) of the Office of Energy Efficiency and Renewable Energy (EE). The annual summary report for 1995 (ASR 95) contains the following: program description (including BCTR program mission statement, historical background, relevance, goals and objectives); program structure and organization, selected technical and programmatic highlights for 1995; detailed descriptions of individual projects; a listing of program output, including a bibliography of published work; patents; and awards arising from work supported by the BCTR.

None

1996-03-01T23:59:59.000Z

396

University Seminar Series Sponsored by the Nanotechnology Graduate Program  

E-Print Network [OSTI]

University Seminar Series Sponsored by the Nanotechnology Graduate Program Imaging Processes in biology and medicine, electrokinetics, and flow control. EVENT DETAILS DATE: February 27, 2013 TIME: 11

Fisher, Frank

397

Community Programs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Programs Friends of Berkeley Lab Navigate Section Community Richmond Bay Campus Planning Tours Community Programs Friends of Berkeley Lab Community Education Programs...

398

Radiation Protection Act (Pennsylvania)  

Broader source: Energy.gov [DOE]

This Act combines the radiation safety provisions of The Atomic Energy Development and Radiation Control Act and the Environmental Radiation Protection Act, and empowers the Department of...

399

Notes: Role of the Nfo and ExoA Apurinic/Apyrimidinic Endonucleases in Radiation Resistance and Radiation-Induced Mutagenesis of Bacillus subtilis Spores  

Science Journals Connector (OSTI)

...Aerospace Medicine, Radiation Biology Department...Group, Chiba-shi, Japan 5 University of Florida...to different types of radiation have been studied...of spore samples for radiation exposure has been described...NIRS) in Chiba, Japan, under the aegis of...

Ralf Moeller; Peter Setlow; Mario Pedraza-Reyes; Ryuichi Okayasu; Gnther Reitz; Wayne L. Nicholson

2011-03-25T23:59:59.000Z

400

Texas Radiation Control Act (Texas) | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Radiation Control Act (Texas) Radiation Control Act (Texas) Texas Radiation Control Act (Texas) < Back Eligibility Utility Commercial Agricultural Investor-Owned Utility Industrial Construction Municipal/Public Utility Local Government Rural Electric Cooperative Tribal Government Program Info State Texas Program Type Environmental Regulations Provider Texas Commission on Environmental Quality It is the policy of the state to institute and maintain a regulatory program for radiation sources that is compatible with federal standards and regulatory programs, and, to the degree possible, compatible with other states' systems. The program permits the development and use of sources of radiation for peaceful purposes consistent with public health and safety and environmental protection. This legislation contains provisions for the

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

NEWTON's Molecular Biology References  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Molecular Biology References Molecular Biology References Do you have a great reference link? Please click our Ideas page. Featured Reference Links: The Vitual Museum of Bacteria The Vitual Museum of Bacteria Visit the virtual museum of bacteria to learn more about bacteria and germs! This site brings together many links on bacteria, bacteriology, and related topics available on the web. It also provides crystal-clear information about many aspects of bacteria. The American Society of Cell Biology Cell Biology Educational Resources This site, sponsered by the American Society of Cell Biology, provides additional web links to everything from, general educational sites, to biology course materials, to teaching tools and more. National Center for Biotechnology Information National Center for Biotechnology Information

402

Style Guide Atmospheric Radiation Measurement (ARM) Climate Research Facility  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Style Guide Style Guide Atmospheric Radiation Measurement (ARM) Climate Research Facility March 2013 Style Guide Atmospheric Radiation Measurement Climate Research Facility March 2013 Work supported by the U.S. Department of Energy, Office of Science, Office of Biological and Environmental Research March 2013 ii Contents 1.0 Introduction .......................................................................................................................................... 1 2.0 Acronyms and Abbreviations ............................................................................................................... 1 2.1 Usage ............................................................................................................................................ 1

403

Concepts of radiation safety and protection: Beyond BEIR V  

SciTech Connect (OSTI)

The publication of an updated report on the biological effects of ionizing radiation (BEIR V) has focused new attention on the potential hazards associated with the use of low doses of ionizing radiation for diagnostic purposes. This article reviews the BEIR V report findings and suggests methods for reducing the risks to dental patients and the operators of dental x-ray equipment.

Farman, A.G. (University of Louisville School of Dentistry, KY (USA))

1991-01-01T23:59:59.000Z

404

Molecular signatures of low dose radiation exposure in human subjects  

Science Journals Connector (OSTI)

...Molecular signatures of low dose radiation exposure in human subjects...Volume 46, 2005] 3096 Low dose ionizing radiation (LDIR) in the 1-10 cGy range has largely unknown biological...the effect and risk at low dose by extrapolation from measured...

Zelanna Goldberg; Chad W. Schwietert; Maggie Isbell; Joerg Lehmann; Robin Stern; Christine Hartmann Siantar; and David M. Rocke

2005-05-01T23:59:59.000Z

405

Is natural background or radiation from nuclear power plants leukemogenic  

SciTech Connect (OSTI)

The objective in this review is to provide some facts about normal hemopoietic cell proliferation relevant to leukemogenesis, physical, chemical, and biological facts about radiation effects with the hope that each person will be able to decide for themselves whether background radiation or emissions from nuclear power plants and facilities significantly add to the spontaneous leukemia incidence. 23 refs., 1 tab.

Cronkite, E.P.

1989-01-01T23:59:59.000Z

406

Radiation protection: Natural radiation risks  

Science Journals Connector (OSTI)

... radiation to which humans are exposed consists of four components - cosmic, gamma, internal, radon. The relative contribution that each makes to the sum is shown in the chart. ... but exposure of the whole body to terrestrial gamma rays and of the lungs to radon daughters are influenced by the nature and location of housing. Gamma rays are emitted ...

M. C. O'Riordan

1983-11-17T23:59:59.000Z

407

Student Internship Programs Program Description  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Student Internship Programs Program Description The objective of the Laboratory's student internship programs is to provide students with opportunities for meaningful hands- on...

408

BWR radiation control: plant demonstration  

SciTech Connect (OSTI)

The first year's progress is presented for a four-year program intended to implement and evaluate BRAC radiation reduction operational guidelines at the Vermont Yankee BWR and to document the results in sufficient detail to provide guidance to other BWR owners. Past operational, chemistry and radiation level data have been reviewed to provide a historical base of reference. Extensive sampling and chemistry monitoring systems have been installed to evaluate plant chemistry status and the effects of program implemented changes. Radiation surveys and piping gamma scans are being performed at targeted locations to quantify radiation level trends and to identify and quantify piping isotopics. Contact radiation levels on the recirculation line at Vermont Yankee have been increasing at a rate of 175 mR/h-EFPY since 1978. A materials survey of feedwater and reactor components in contact with the process liquid has been performed to identify sources of corrosion product release, particularly cobalt and nickel. A feedwater oxygen injection system has been installed to evaluate the effects of oxygen control on feedwater materials corrosion product releases. A baseline performance evaluation of the condensate treatment and reactor water cleanup systems has been completed. Data on organics and ionics at Vermont Yankee have been obtained. A methodology of BWR feedwater system layup during extended outages was developed, and an evaluation performed of layup and startup practices utilized at Vermont Yankee during the fall 1980 and 1981 refueling outages.

Palino, G.F.; Hobart, R.L.; Wall, P.S.; Sawochka, S.G.

1982-11-01T23:59:59.000Z

409

Mechanisms underlying cellular responses of cells from haemopoietic tissue to low dose/low LET radiation  

SciTech Connect (OSTI)

To accurately define the risks associated with human exposure to relevant environmental doses of low LET ionizing radiation, it is necessary to completely understand the biological effects at very low doses (i.e., less than 0.1 Gy), including the lowest possible dose, that of a single electron track traversal. At such low doses, a range of studies have shown responses in biological systems which are not related to the direct interaction of radiation tracks with DNA. The role of these non-targeted responses in critical tissues is poorly understood and little is known regarding the underlying mechanisms. Although critical for dosimetry and risk assessment, the role of individual genetic susceptibility in radiation risk is not satisfactorily defined at present. The aim of the proposed grant is to critically evaluate radiation-induced genomic instability and bystander responses in key stem cell populations from haemopoietic tissue. Using stem cells from two mouse strains (CBA/H and C57BL/6J) known to differ in their susceptibility to radiation effects, we plan to carefully dissect the role of genetic predisposition on two non-targeted radiation responses in these models; the bystander effect and genomic instability, which we believe are closely related. We will specifically focus on the effects of low doses of low LET radiation, down to doses approaching a single electron traversal. Using conventional X-ray and ?-ray sources, novel dish separation and targeted irradiation approaches, we will be able to assess the role of genetic variation under various bystander conditions at doses down to a few electron tracks. Irradiations will be carried out using facilities in routine operation for bystander targeted studies. Mechanistic studies of instability and the bystander response in different cell lineages will focus initially on the role of cytokines which have been shown to be involved in bystander signaling and the initiation of instability. These studies also aim to uncover protein mediators of the bystander responses using advanced proteomic screening of factors released from irradiated, bystander and unstable cells. Integral to these studies will be an assessment of the role of genetic susceptibility in these responses, using CBA/H and C57BL/6J mice. The relevance of in vivo interactions between stem cells and the stem cell niche will be explored in the future by re-implantation techniques of previously irradiated cells. The above studies will provide fundamental mechanistic information relating genetic predisposition to important low dose phenomena, and will aid in the development of Department of Energy policy, as well as radiation risk policy for the public and the workplace. We believe the proposed studies accurately reflect the goals of the DOE low dose program.

Munira A Kadhim

2010-03-05T23:59:59.000Z

410

Abiotic Production of Methylmercury by Solar Radiation  

Science Journals Connector (OSTI)

Abiotic Production of Methylmercury by Solar Radiation ... Department of Soil Science, 51 Campus Drive, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5A8, Department of Biology, University of Ottawa, 30 Marie Curie, P.O. ... Canadian Journal of Fisheries and Aquatic Sciences (2000), 57 (5), 1080-1091 CODEN: CJFSDX; ISSN:0706-652X. ...

Steven D. Siciliano; Nelson J. O'Driscoll; Robert Tordon; Jonathan Hill; Stephen Beauchamp; David R. S. Lean

2005-01-07T23:59:59.000Z

411

Theory of Biological Cleanroom  

Science Journals Connector (OSTI)

Modern biological cleanroom was developed on the basis of the industrial cleanroom. Except for the common principles of the cleanroom, the specific principles for the control of...

Zhonglin Xu

2014-01-01T23:59:59.000Z

412

Code of Federal Regulations Occupational Radiation Protection; Final Rule |  

Broader source: Energy.gov (indexed) [DOE]

Code of Federal Regulations Occupational Radiation Protection; Code of Federal Regulations Occupational Radiation Protection; Final Rule Code of Federal Regulations Occupational Radiation Protection; Final Rule The Department of Energy (DOE) is amending its primary standards for occupational radiation protection. This final rule is the culmination of a systematic analysis to identify the elements of a comprehensive radiation protection program and determine those elements of such a program that should be codified as DOE continues its transition from a system of contractually-based nuclear safety standards to regulatory based requirements. Code of Federal Regulations Occupational Radiation Protection; Final Rule More Documents & Publications Code of Federal Regulations PART 835-OCCUPATIONAL RADIATION PROTECTION Order Module--NNSA OCCUPATIONAL RADIATION PROTECTION

413

1993 Radiation Protection Workshop: Proceedings  

SciTech Connect (OSTI)

The 1993 DOE Radiation Protection Workshop was conducted from April 13 through 15, 1993 in Las Vegas, Nevada. Over 400 Department of Energy Headquarters and Field personnel and contractors from the DOE radiological protection community attended the Workshop. Forty-nine papers were presented in eleven separate sessions: Radiological Control Manual Implementation, New Approaches to Instrumentation and Calibration, Radiological Training Programs and Initiatives, External Dosimetry, Internal Dosimetry, Radiation Exposure Reporting and Recordkeeping, Air Sampling and Monitoring Issues, Decontamination and Decommissioning of Sites, Contamination Monitoring and Control, ALARA/Radiological Engineering, and Current and Future Health Physics Research. Individual papers are indexed separately on the database.

Not Available

1993-12-31T23:59:59.000Z

414

Radiation, Infection, and Macrophage Function IV. Effect of Radiation on the Proliferative Abilities of Mononuclear Phagocytes in Tuberculous Lesions of Rabbits  

Science Journals Connector (OSTI)

...likely interpretation would be that radiation reduced MN production in the bone...the auspices of the United States- Japan Cooperative Medical Science Program...of tuberculosis: VOL. 3, 1971 RADIATION, INFECTION, AND MACROPHAGE FUNCTION...

Saroj Chandrasekhar; Kiyoshi Shima; Arthur M. Dannenberg Jr.; Takeshi Kambara; Jacob I. Fabrikant; William G. Roessler

1971-02-01T23:59:59.000Z

415

ECOLOGY & EVOLUTION CONSERVATION BIOLOGY  

E-Print Network [OSTI]

.arlettaz@iee.unibe.ch www.conservation.unibe.ch Grassland management: designing tomorrow's farmland for biodiversity 1ECOLOGY & EVOLUTION CONSERVATION BIOLOGY Prof. Dr Raphaël Arlettaz Head of the division of Conservation Biology Office: Erlachstrasse 9a Mail: Baltzerstrasse 6 CH­3012 Bern +41 31 631 31 61 +41 79 637

Richner, Heinz

416

NANOTECHNOLOGY IN BIOLOGY AND  

E-Print Network [OSTI]

NANOTECHNOLOGY IN BIOLOGY AND MEDICINE Methods, Devices, and Applications #12;CRC Press Taylor to infringe. Library of Congress Cataloging-in-Publication Data Nanotechnology in biology and medicine. paper) 1. Nanotechnology. 2. Biomedical engineering. 3. Medical technology. I. Vo-Dinh, Tuan. [DNLM: 1

Pennycook, Steve

417

Integrated Biological Control  

SciTech Connect (OSTI)

Biological control is any activity taken to prevent, limit, clean up, or remediate potential environmental, health and safety, or workplace quality impacts from plants, animals, or microorganisms. At Hanford the principal emphasis of biological control is to prevent the transport of radioactive contamination by biological vectors (plants, animals, or microorganisms), and where necessary, control and clean up resulting contamination. Other aspects of biological control at Hanford include industrial weed control (e.g.; tumbleweeds), noxious weed control (invasive, non-native plant species), and pest control (undesirable animals such as rodents and stinging insects, and microorganisms such as molds that adversely affect the quality of the workplace environment). Biological control activities may be either preventive (a priori) or in response to existing contamination spread (a posteriori). Surveillance activities, including ground, vegetation, flying insect, and other surveys, and a priori control actions, such as herbicide spraying and placing biological barriers, are important in preventing radioactive contamination spread. If surveillance discovers that biological vectors have spread radioactive contamination, a posteriori control measures, such as fixing contamination, followed by cleanup and removal of the contamination to an approved disposal location are typical response functions. In some cases remediation following the contamination cleanup and removal is necessary. Biological control activities for industrial weeds, noxious weeds and pests have similar modes of prevention and response.

JOHNSON, A.R.

2003-10-09T23:59:59.000Z

418

Integrated Biological Control  

SciTech Connect (OSTI)

Biological control is any activity taken to prevent, limit, clean up, or remediate potential environmental, health and safety, or workplace quality impacts from plants, animals, or microorganisms. At Hanford the principal emphasis of biological control is to prevent the transport of radioactive contamination by biological vectors (plants, animals, or microorganisms), and where necessary, control and clean up resulting contamination. Other aspects of biological control at Hanford include industrial weed control (e.g.; tumbleweeds), noxious weed control (invasive, non-native plant species), and pest control (undesirable animals such as rodents and stinging insects; and microorganisms such as molds that adversely affect the quality of the workplace environment). Biological control activities may be either preventive (apriori) or in response to existing contamination spread (aposteriori). Surveillance activities, including ground, vegetation, flying insect, and other surveys, and apriori control actions, such as herbicide spraying and placing biological barriers, are important in preventing radioactive contamination spread. If surveillance discovers that biological vectors have spread radioactive contamination, aposteriori control measures, such as fixing contamination, followed by cleanup and removal of the contamination to an approved disposal location are typical response functions. In some cases remediation following the contamination cleanup and removal is necessary. Biological control activities for industrial weeds, noxious weeds and pests have similar modes of prevention and response.

JOHNSON, A.R.

2002-09-01T23:59:59.000Z

419

Biology and Soft Matter Division - ORNL Neutron Sciences  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Home › Neutron Sciences Directorate › Biology and Soft Matter Division Home › Neutron Sciences Directorate › Biology and Soft Matter Division Biology and Soft Matter Division Paul Langan, BSMD Director BSMD Director Paul Langan. The Biology and Soft Matter Division (BSMD) operates an external user program for biological and soft matter research using neutron techniques at SNS and HFIR. Division personnel enable the research initiated by external users by acting as instrument responsible scientists and local contacts on a range of different beam lines. BSMD works closely with the Center for Structural Molecular Biology. Diffraction, small-angle scattering, and reflectometry are ideal methods for studying structure and organization from the atomic to the micron length scales, and neutron spectroscopic methods characterize self and

420

Biology and Soft Matter Division | Neutron Science | ORNL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Biology and Soft Matter Division Biology and Soft Matter Division SHARE Biology and Soft Matter Division BSMD Director Paul Langan The Biology and Soft Matter Division (BSMD) operates an external user program for biological and soft matter research using neutron techniques at SNS and HFIR. Division personnel enable the research initiated by external users by acting as instrument responsible scientists and local contacts on a range of different beam lines. BSMD works closely with the Center for Structural Molecular Biology. Diffraction, small-angle scattering, and reflectometry are ideal methods for studying structure and organization from the atomic to the micron length scales, and neutron spectroscopic methods characterize self and collective motions from picosecond to microsecond timescales. These

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Fluorescence cross section measurements of biological agent simulants  

SciTech Connect (OSTI)

Fluorescence is a powerful technique that has potential uses in detection and characterization of biological aerosols both in the battlefield and in civilian environments. Fluorescence techniques can be used with ultraviolet (UV) light detection and ranging (LIDAR) equipment to detect biological aerosol clouds at a distance, to provide early warning of a biological attack, and to track an potentially noxious cloud. Fluorescence can also be used for detection in a point sensor to monitor biological materials and to distinguish agents from benign aerosols. This work is part of a continuing program by the Army`s Chemical and Biological Defense Command to characterized the optical properties of biological agents. Reported here are ultraviolet fluorescence measurements of Bacillus megaterium and Bacillus Globigii aerosols suspended in an electrodynamic particle trap. Fluorescence spectra of a common atmospheric aerosol, pine pollen, are also presented.

Stephens, J.R.

1996-11-01T23:59:59.000Z

422

HANDBOOK CONTENT Page THE MLML GRADUATE PROGRAM  

E-Print Network [OSTI]

V. Graduate Student Handbook #12;HANDBOOK CONTENT Page THE MLML GRADUATE PROGRAM MLML Mission 1 broadly and specific to their field of study, such as physical oceanography, biological oceanography

McPhee-Shaw, Erika

423

Structural biology research at the National Synchroton Light Source  

SciTech Connect (OSTI)

The world`s foremost facility for scientific research using x-rays and ultraviolet and infrared radiation is operated by the national synchrotron Light Source Department. This year alone, a total of 2200 guest researchers performed experiments at the world`s largest source of synchrotron light. Researchers are trying to define the three- dimensional structures of biological macromolecules to create a map of life, a guide for exploring the biological and chemical interactions of the vast variety of molecules found in living organisms. Studies in structural biology may lead to new insights into how biological systems are formed and nourished, how they survive and grow, how they are damaged and die. This document discusses some the the structural biological research done at the National Synchrotron Light Source.

NONE

1996-05-01T23:59:59.000Z

424

Synthetic biology: Understanding biological design from synthetic circuits  

E-Print Network [OSTI]

An important aim of synthetic biology is to uncover the design principles of natural biological systems through the rational design of gene and protein circuits. Here, we highlight how the process of engineering biological ...

Mukherji, Shankar

425

Radiating gravastars  

SciTech Connect (OSTI)

Considering a Vaidya exterior spacetime, we study dynamical models of prototype gravastars, made of an infinitely thin spherical shell of a perfect fluid with the equation of state p = ?, enclosing an interior de Sitter spacetime. We show explicitly that the final output can be a black hole, an unstable gravastar, a stable gravastar or a 'bounded excursion' gravastar, depending on how the mass of the shell evolves in time, the cosmological constant and the initial position of the dynamical shell. This work presents, for the first time in the literature, a gravastar that emits radiation.

Chan, R. [Coordenao de Astronomia e Astrofsica, Observatrio Nacional, Rua General Jos Cristino, 77, So Cristvo 20921-400, Rio de Janeiro, RJ (Brazil); Silva, M.F.A. da [Departamento de Fsica Terica, Instituto de Fsica, Universidade do Estado do Rio de Janeiro, Rua So Francisco Xavier 524, Maracan 20550-900, Rio de Janeiro - RJ (Brazil); Rocha, Jaime F. Villas da [Instituto de Biocincias, Departamento de Cincias Naturais, Universidade Federal do Estado do Rio de Janeiro, Av. Pasteur 458, Urca, CEP 22290-240, Rio de Janeiro, RJ (Brazil); Wang, Anzhong, E-mail: chan@on.br, E-mail: mfasnic@gmail.com, E-mail: jfvroch@pq.cnpq.br, E-mail: anzhong_wang@baylor.edu [GCAP-CASPER, Department of Physics, Baylor University, Waco, TX 76798 (United States)

2011-10-01T23:59:59.000Z

426

Monte Carlo Simulation of Electromagnetic Interactions of Radiation with Liquid Water in  

E-Print Network [OSTI]

; nevertheless the concept of dose is not adequate to estimate the radiation effects when microscopic entitiesMonte Carlo Simulation of Electromagnetic Interactions of Radiation with Liquid Water. They address a physics domain relevant to the simulation of radiation effects in biological systems, where

Paris-Sud XI, Université de

427

RADIATION RESEARCH 145,501-507 (1996) 0033-7587196 $5.00  

E-Print Network [OSTI]

range of most interest for risk estimation for low-dose radiation (-900-1,450 m), predictions Biological Evidence for a Significant Neutron Dose to Survivors of the Hiroshima Atomic Bomb. Radiat. Res-bomb survivor cohorts in radiation risk estimation, dosimetry for the sur- vivors at Hiroshima and Nagasaki

Brenner, David Jonathan

428

AN INTEGRATED BIOLOGICAL CONTROL SYSTEM AT HANFORD  

SciTech Connect (OSTI)

In 1999 an integrated biological control system was instituted at the U.S. Department of Energy's Hanford Site. Successes and changes to the program needed to be communicated to a large and diverse mix of organizations and individuals. Efforts at communication are directed toward the following: Hanford Contractors (Liquid or Tank Waste, Solid Waste, Environmental Restoration, Science and Technology, Site Infrastructure), General Hanford Employees, and Hanford Advisory Board (Native American Tribes, Environmental Groups, Local Citizens, Washington State and Oregon State regulatory agencies). Communication was done through direct interface meetings, individual communication, where appropriate, and broadly sharing program reports. The objectives of the communication efforts was to have the program well coordinated with Hanford contractors, and to have the program understood well enough that all stakeholders would have confidence in the work performed by the program to reduce or elimated spread of radioactive contamination by biotic vectors. Communication of successes and changes to an integrated biological control system instituted in 1999 at the Department of Energy's Hanford Site have required regular interfaces with not only a diverse group of Hanford contractors (i.e., those responsible for liquid or tank waste, solid wastes, environmental restoration, science and technology, and site infrastructure), and general Hanford employees, but also with a consortium of designated stake holders organized as the Hanford Advisory Board (i.e., Native American tribes, various environmental groups, local citizens, Washington state and Oregon regulatory agencies, etc.). Direct interface meetings, individual communication where appropriate, and transparency of the biological control program were the methods and outcome of this effort.

JOHNSON AR; CAUDILL JG; GIDDINGS RF; RODRIGUEZ JM; ROOS RC; WILDE JW

2010-02-11T23:59:59.000Z

429

Natural and Radiation Carcinogenesis in Man. III. Radiation Carcinogenesis  

Science Journals Connector (OSTI)

...mice. NATURAL AND RADIATION CARCINOGENESIS IN MAN. 3. RADIATION CARCINOGENESIS. | Journal Article | Japan Neoplasms etiology Neoplasms, Radiation-Induced Radiation Genetics | JAPAN NEOPLASM ETIOLOGY NEOPLASMS, RADIATION-INDUCED RADIATION...

1965-01-01T23:59:59.000Z

430

Designing Synthetic Biology  

Science Journals Connector (OSTI)

(14) The science of biology and the practice of engineering (knowing and making(15)) are especially connected in parts-based synthetic biology, where many engineers and scientists seek to build life to understand it through the assembly of standardized genetic modules. ... This iterative refinement of the refactored operon led to a detailed mapping of the genetic design space and an engineered pathway that produced wild-type levels of nitrogen fixation. ... (22) The positive feedback between science and engineering in synthetic biology has been compared to the history of other disciplines and industries, such as aviation(23) or synthetic chemistry. ...

Christina M. Agapakis

2013-10-24T23:59:59.000Z

431

BNL NASA Space Radiation Laboratory  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Purpose: To use beams of heavy ions provided by the Booster accelerator at Brookhaven to study the effects of simulated space radiation on biological and physical systems, with the goal of developing methods and materials to reduce the risk to human beings on prolonged space missions of the effects of ionizing radiation Sponsor: National Aeronautics and Space Administration (NASA) Project cost $34 million over 4 years Operating costs Nearly $8 million per year in 2007 Features * beams of heavy ions extracted from the Booster accelerator with masses and energies similar to the cosmic rays encountered in space: * 1-billion electron volt (GeV)/nucleon iron-56 * 0.3-GeV/nucleon gold-97 * 0.6-GeV/nucleon silicon-28 * 1-GeV/nucleon protons * 1-GeV/nucleon titanium

432

Biological & Environmental Research Abstracts Database  

Office of Scientific and Technical Information (OSTI)

Welcome to the Biological and Environmental Research Abstracts Database The U.S. Department of Energy's Office of Biological and Environmental Research (BER) conducts research in...

433

Green Biologics | Open Energy Information  

Open Energy Info (EERE)

Biologics Jump to: navigation, search Name: Green Biologics Place: Oxfordshire, United Kingdom Sector: Biomass, Renewable Energy Product: Oxfordshire-based industrial biotech...

434

Adaptors for radiation detectors  

DOE Patents [OSTI]

Described herein are adaptors and other devices for radiation detectors that can be used to make accurate spectral measurements of both small and large bulk sources of radioactivity, such as building structures, soils, vessels, large equipment, and liquid bodies. Some exemplary devices comprise an adaptor for a radiation detector, wherein the adaptor can be configured to collimate radiation passing through the adapter from an external radiation source to the radiation detector and the adaptor can be configured to enclose a radiation source within the adapter to allow the radiation detector to measure radiation emitted from the enclosed radiation source.

Livesay, Ronald Jason

2014-04-22T23:59:59.000Z

435

Thornridge Biology Home Page  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

How Do We Inherit Our Biological Characteristics How Do We Inherit Our Biological Characteristics How Do We Inherit Our Biological Characteristics? Shelly Peretz Science Department Chairperson Thornridge High School Office Phone: 708-225-4585 speretz@interaccess.com You are visitor Photograph taken from Genetic Pathology Gallery: Cytogenetics, University of Washington Medical Center. Be sure to submit the online sign-off each day. Introduction Individuals, families, health care providers and policymakers face important health care decisions every day. Today, with the growing awareness of the role that genetics plays in our society, decision-making requires more information than ever before. This project uses principles of biology to examine human genetics disorders. Students work in small groups (2-3) on projects which give them the opportunity to understand human

436

Work with Biological Materials  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Work with Biological Materials Print Planning A complete Experiment Safety Sheet (ESS) is required before work can be done at the ALS. This ESS is either a part of the proposal...

437

Biological Interactions and Dynamics  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

PNNL-20717 Biological Interactions and Dynamics Science Theme Advisory Panel (BID-STAP) May 2011 Report: September 2011 Prepared for the U.S. Department of Energy's Office of...

438

Automation in biological crystallization  

Science Journals Connector (OSTI)

Automation is the response to overcoming the crystallization bottleneck in biological crystallography. This review provides a summary of the current methods and technologies applied in automated platforms for the setup of initial and follow-up crystallization experiments.

Shaw Stewart, P.

2014-05-28T23:59:59.000Z

439

Thermodynamics in biological systems  

Science Journals Connector (OSTI)

... An EMBO-sponsored Workshop on Thermodynamics in Biological Systems was held at the Villa Durazzo at Santa Margherita Ligure under the ... auspices of the University of Genoa on April 5?9, 1976.

A Correspondent

1976-05-27T23:59:59.000Z

440

Cell Cycle Disturbances and Mitotic Catastrophes in HeLa Hep2 Cells following 2.5 to 10 Gy of Ionizing Radiation  

Science Journals Connector (OSTI)

...death (2-5). Radiation is known to exert...molecules involved in this radiation-induced cellular safety machinery is p53...different doses of radiation at the molecular and...using the CellQuest software program, setting...

David Eriksson; Per-Olov Lfroth; Lennart Johansson; Katrine hlstrm Riklund; and Torgny Stigbrand

2007-09-15T23:59:59.000Z

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Program Manager  

Broader source: Energy.gov [DOE]

A successful candidate in this position will participate in a wide spectrum of program and project management activities involving systems engineering and integration support for Defense Programs...

442

Program Managers  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Program Managers Program Managers Enabling remarkable discoveries and tools that transform our understanding of energy and matter and advance national, economic, and energy...

443

Retiree Program  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Library Services Retiree Program Retiree Program The Research Library offers a 1 year library card to retired LANL employees that allows usage of Library materials. This service...

444

Educational Programs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Educational Programs Educational Programs A collaboration between Los Alamos National Laboratory and the University of California at San Diego (UCSD) Jacobs School of Engineering...

445

Radiation Emergency Assistance Center / Training Site | National Nuclear  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Radiation Emergency Assistance Center / Training Site | National Nuclear Radiation Emergency Assistance Center / Training Site | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Radiation Emergency Assistance Center / Training Site Home > About Us > Our Programs > Emergency Response > Responding to Emergencies > Consequence Management > Radiation Emergency Assistance

446

Coherent Synchrotron Radiation: Theory and Simulations.  

SciTech Connect (OSTI)

The physics of coherent synchrotron radiation (CSR) emitted by ultra-relativistic electron bunches, known since the last century, has become increasingly important with the development of high peak current free electron lasers and shorter bunch lengths in storage rings. Coherent radiation can be described as a low frequency part of the familiar synchrotron radiation in bending magnets. As this part is independent of the electron energy, the fields of different electrons of a short bunch can be in phase and the total power of the radiation will be quadratic with the number of electrons. Naturally the frequency spectrum of the longitudinal electron distribution in a bunch is of the same importance as the overall electron bunch length. The interest in the utilization of high power radiation from the terahertz and far infrared region in the field of chemical, physical and biological processes has led synchrotron radiation facilities to pay more attention to the production of coherent radiation. Several laboratories have proposed the construction of a facility wholly dedicated to terahertz production using the coherent radiation in bending magnets initiated by the longitudinal instabilities in the ring. Existing synchrotron radiation facilities also consider such a possibility among their future plans. There is a beautiful introduction to CSR in the 'ICFA Beam Dynamics Newsletter' N 35 (Editor C. Biscari). In this paper we recall the basic properties of CSR from the theory and what new effects, we can get from the precise simulations of the coherent radiation using numerical solutions of Maxwell's equations. In particular, transverse variation of the particle energy loss in a bunch, discovered in these simulations, explains the slice emittance growth in bending magnets of the bunch compressors and transverse de-coherence in undulators. CSR may play same the role as the effect of quantum fluctuations of synchrotron radiation in damping rings. It can limit the minimum achievable emittance in the synchrotron light sources for short bunches.

Novokhatski, Alexander; /SLAC

2012-03-29T23:59:59.000Z

447

Atmospheric Radiation Measurement (ARM) Data Products from Principal Investigators  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

The Office of Biological and Environmental Research in DOE's Office of Science is responsible for the ARM Program. The ARM Archive physically resides at the Oak Ridge National Laboratory.

448

HPC Program Reviews  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Advanced Scientific Computing Research (ASCR) Advanced Scientific Computing Research (ASCR) Basic Energy Sciences (BES) Fusion Energy Sciences (FES) High Energy Physics (HEP) Biological and Environmental Research (BER) Requirements for Science: Target 2014 Overview Published Reports Case Study FAQs Home » Science at NERSC » HPC Requirements Reviews HPC Requirements Reviews In support of its mission and to maintain its reputation as one of the best run scientific computing centers in the world, NERSC continually gathers requirements from its user community, the DOE Office of Science program offices, and from other key HPC or domain experts. These requirements are collected via a series of NERSC Program Requirements Reviews with each of the six DOE Office of Science program offices. The first set of reviews ran from May 2009 through May 2011 and resulted in

449

Environmental Programs Environmental Programs Committee  

E-Print Network [OSTI]

(Architecture) The Environmental Programs Committee coordinates courses and curricula on environmental topics. Wiesner (Civil and Environmental Engineering) Gordon G. Wittenberg (Architecture) #12;162 Environmental Programs Environmental Programs Committee Walter Whitfield Isle, Chair (English

Richards-Kortum, Rebecca

450

SRS - Programs - Nonproliferation Programs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

3/2012 3/2012 SEARCH GO spacer SRS Home Nonproliferation Programs In the crucial field of nuclear nonproliferation, SRS employee contributions helped to advance all three of the planned plutonium disposition facilities at the Savannah River Site: the Pit Disassembly and Conversion Facility (PDCF); Waste Solidification Building (WSB); and the Mixed Oxide (MOX) Fuel Fabrication Facility. A $345 million project, the WSB will process liquid waste from the MOX facility. After material is processed at the WSB, transuranic waste will be packaged and sent to the Waste Isolation Pilot Plant in New Mexico, and low-level waste will be packaged and sent to onsite or commercial off-site low-level waste disposal facilities. The mixed oxide fuel fabrication facility will be a major component in the United States' program to dispose of excess weapons grade plutonium.

451

Report of The Structural Biology Subcommittee of The Biological and  

Office of Science (SC) Website

Report of The Structural Biology Subcommittee of The Report of The Structural Biology Subcommittee of The Biological and Environmental Research Advisory Committee Biological and Environmental Research Advisory Committee (BERAC) BERAC Home Meetings Members Charges/Reports Current BERAC Charges Archive of BERAC Reports Charter .pdf file (40KB) BER Committees of Visitors BER Home Charges/Reports Report of The Structural Biology Subcommittee of The Biological and Environmental Research Advisory Committee Print Text Size: A A A RSS Feeds FeedbackShare Page REPORT of the STRUCTURAL BIOLOGY SUBCOMMITTEE of the BIOLOGICAL AND ENVIRONMENTAL RESEARCH ADVISORY COMMITTEE In response to the charge letter of Dr. Martha Krebs, May 28, 1998 Executive Summary Structural biology and especially macromolecular crystallography are playing an increasingly important role in biological discoveries. In order

452

Ionizing Radiation Damage to the Folded Chromosome of Escherichia coli K-12: Repair of Double-Strand Breaks in Deoxyribonucleic Acid  

Science Journals Connector (OSTI)

...cell survival Dose (krad) % Recovery...it is in the range of sedimentation...that direct, radiation-induced cross-linking...during repair of ionizing radiation damage (3...is within the range ofsedimentation...biologically significant dose range. Unfortu...

Kevin M. Ulmer; Reinaldo F. Gomez; Anthony J. Sinskey

1979-05-01T23:59:59.000Z

453

Biological and Environmental Research Network Requirements  

SciTech Connect (OSTI)

The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the U.S. Department of Energy (DOE) Office of Science (SC), the single largest supporter of basic research in the physical sciences in the United States. In support of SC programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet be a highly successful enabler of scientific discovery for over 25 years. In November 2012, ESnet and the Office of Biological and Environmental Research (BER) of the DOE SC organized a review to characterize the networking requirements of the programs funded by the BER program office. Several key findings resulted from the review. Among them: 1) The scale of data sets available to science collaborations continues to increase exponentially. This has broad impact, both on the network and on the computational and storage systems connected to the network. 2) Many science collaborations require assistance to cope with the systems and network engineering challenges inherent in managing the rapid growth in data scale. 3) Several science domains operate distributed facilities that rely on high-performance networking for success. Key examples illustrated in this report include the Earth System Grid Federation (ESGF) and the Systems Biology Knowledgebase (KBase). This report expands on these points, and addresses others as well. The report contains a findings section as well as the text of the case studies discussed at the review.

Dart, Eli; Tierney, Brian

2013-09-01T23:59:59.000Z

455

Research Councils UK Synthetic biology  

E-Print Network [OSTI]

, bioinformatics approaches and DNA synthesis, all of which are central to the current field of synthetic biologyResearch Councils UK Synthetic biology #12;Synthetic biology Research funded by the Research them commercially. Synthetic biology is one of `Eight Great Technologies' identified by the Chancellor

Berzins, M.

456

California: Breakthrough in Algae Biology  

Office of Energy Efficiency and Renewable Energy (EERE)

Breakthrough in algae biology will have a significant impact in the economics of algal biofuel production.

457

Nuclear radiation electronic gear  

Science Journals Connector (OSTI)

Nuclear radiation electronic gear ... Examines the line of nuclear radiation instrumentation offered by Nuclear-Chicago Corporation and Victoreen Instrument Company. ... Nuclear / Radiochemistry ...

S. Z. Lewin

1961-01-01T23:59:59.000Z

458

Radiological Assistance Program (RAP)- Nuclear Engineering Division  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Major Programs > Radiological Major Programs > Radiological Assistance Program Radiological Assistance Program Overview Other Major Programs Work with Argonne Contact us For Employees Site Map Help Join us on Facebook Follow us on Twitter NE Division on Flickr Radiological Assistance Program Bookmark and Share Survey equipment is used to detect and measure radiation Survey equipment is used to detect and measure radiation. Click on image to view larger image. The Radiological Assistance Program (RAP) team at Argonne can provide assistance in the event of a radiological accident or incident. Support ranges from giving technical information or advice over the telephone, to sending highly trained team members and state-of-the-art equipment to the accident site to help identify and minimize any radiological hazards. The

459

Biology Chemistry Math  

E-Print Network [OSTI]

FREE EVENING SCIENCE hELP CENTER. COSINE (College of Science Instructional Nightly. Enrichment) is a FREE tutoring program to help students succeed...

tsiemers

2014-08-21T23:59:59.000Z

460

Wheat Improvement Programs WHEAT PROGRAM  

E-Print Network [OSTI]

. Royalty revenues, which assist funding of programs and attracting/retaining top scientists, have increased

Note: This page contains sample records for the topic "radiation biology program" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Report of the Structural Biology Subcommittee of the Biological and  

Office of Science (SC) Website

Report of the Structural Biology Subcommittee of the Report of the Structural Biology Subcommittee of the Biological and Environmental Research Advisory Committee Biological and Environmental Research Advisory Committee (BERAC) BERAC Home Meetings Members Charges/Reports Current BERAC Charges Archive of BERAC Reports Charter .pdf file (40KB) BER Committees of Visitors BER Home Charges/Reports Report of the Structural Biology Subcommittee of the Biological and Environmental Research Advisory Committee Print Text Size: A A A RSS Feeds FeedbackShare Page REPORT of the STRUCTURAL BIOLOGY SUBCOMMITTEE of the BIOLOGICAL AND ENVIRONMENTAL RESEARCH ADVISORY COMMITTEE In response to the charge letter of Dr. Martha Krebs, June 10, 1997 Executive Summary Six years have elapsed since the previous report of the Structural Biology Subcommittee. Dramatic progress and advances in the field over this period

462

INEL Geothermal Environmental Program. Final environmental report  

SciTech Connect (OSTI)

An overview of environmental monitoring programs and research during development of a moderate temperature geothermal resource in the Raft River Valley is presented. One of the major objectives was to develop programs for environmental assessment and protection that could serve as an example for similar types of development. The monitoring studies were designed to establish baseline conditions (predevelopment) of the physical, biological, and human environment. Potential changes were assessed and adverse environmental impacts minimized. No major environmental impacts resulted from development of the Raft River Geothermal Research Facility. The results of the physical, biological, and human environment monitoring programs are summarized.

Thurow, T.L.; Cahn, L.S.

1982-09-01T23:59:59.000Z

463

A U. S. Department of Energy User Facility Atmospheric Radiation  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Program DOESC-ARMP-07-003 Science and Research Data Products Climate Data for the World A primary objective of the U.S. Department of Energy's Atmospheric Radiation...

464

college of engineering DEgrEE ProgrAmS  

E-Print Network [OSTI]

» Manufacturing engineering » Mechanical engineering » nuclear engineering » radiation Health Physics o » Medical Physics » nuclear engineering » radiation Health Physics » School of chemical, Biological and computer Science » School of Mechanical, industrial, and Manufacturing engineering » Department of nuclear

Tullos, Desiree

465

Radiative Importance of ThinŽ Liquid Water Clouds  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Program Program Accomplishments of the Instantaneous Radiative Flux (IRF) Working Group August 2006 AERI Observations at Southern Great Plains Improve Infrared Radiative Transfer Models Turner et al., JAS, 2004 * AERI observations used to evaluate clear sky IR radiative transfer models * Long-term comparisons have improved - Spectral line database parameters - Water vapor continuum absorption models * Reduced errors in computation of downwelling radiative IR flux by approx 4; current uncertainty is on the order of 1.5 W/m 2 AERI - (Pre-ARM Model) AERI - (Model in 2003) 1 RU = 1 mW / (m 2 sr cm -1 ) Excellent Agreement in Clear Sky Shortwave Radiative Transfer Between Obs and Calcs Shortwave Flux Bias (Solid) Shortwave Flux RMS (Hatched) W m -2 * Comparison of shortwave radiative flux at the surface

466

Educational Programs  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Programs Programs Argonne National Laboratory Educational Programs Search Argonne ... Search Argonne Home > Educational Programs > Welcome Type of Appointments Postdoctoral Newsletters Postdoctoral Office Activities Postdoctoral Programs Alumni Postdoctoral Society of Argonne Newcomers Assistance Office Postdoctoral Resources Postdoctoral Mentoring Program Contact Us Schedule of Career Development Seminars Organized by the Postdoctoral Office for 2011 Here is a schedule of all of our Career Development Seminars and Workshops! Normally, the events happen at lunchtime and food is provided. The topics of these events include: Journal Clubs Career Development Networking We welcome all of our Postdocs and colleagues to and join us! Wednesday January 19 Postdoc Journal Club and pizza lunch. Magnetic Domain-Wall Racetrack Memory

467

Institute for Multiscale Modeling of Biological Interactions  

SciTech Connect (OSTI)

The Institute for Multiscale Modeling of Biological Interactions (IMMBI) has two primary goals: Foster interdisciplinary collaborations among faculty and their research laboratories that will lead to novel applications of multiscale simulation and modeling methods in the biological sciences and engineering; and Building on the unique biophysical/biology-based engineering foundations of the participating faculty, train scientists and engineers to apply computational methods that collectively span multiple time and length scales of biological organization. The success of IMMBI will be defined by the following: Size and quality of the applicant pool for pre-doctoral and post-doctoral fellows; Academic performance; Quality of the pre-doctoral and post-doctoral research; Impact of the research broadly and to the DOE (ASCR program) mission; Distinction of the next career step for pre-doctoral and post-doctoral fellows; and Faculty collaborations that result from IMMBI activities. Specific details about accomplishments during the three years of DOE support for IMMBI have been documented in Annual Progress Reports (April 2005, June 2006, and March 2007) and a Report for a National Academy of Sciences Review (October 2005) that were submitted to DOE on the dates indicated. An overview of these accomplishments is provided.

Michael E. Paulaitis

2009-12-26T23:59:59.000Z

468

EMSL: Science: Research and Capability Development Program  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Intramural Research & Capability Development Program Intramural Research & Capability Development Program The EMSL Intramural Research and Capability Development Program facilitates development of new research tools and enables EMSL staff members to advance the important skills and expertise necessary to enhance the EMSL user program. These intramural projects are intended to increase the scientific visibility of EMSL staff in areas that promote the objectives of EMSL's three science themes- Biological Interactions and Dynamics, Geochemistry/Biogeochemistry and Subsurface Science, and Science of Interfacial Phenomena. Technical outcomes of this program include journal publications, scientific presentations, new capabilities or capability enhancements, and expertise to augment EMSL user activities and foster development of innovative

469

Biology of Borrelia species.  

Science Journals Connector (OSTI)

...biology of this genus and, to some extent, acquaint investi- gators of this generation with the large body of works of past generations...taxonomy. Another phenotype that was judged by previous investi- gators to be important for any classification scheme for borreliae...

A G Barbour; S F Hayes

1986-12-01T23:59:59.000Z

470

CANCER BIOLOGY Infectioustumourcells  

E-Print Network [OSTI]

CANCER BIOLOGY Infectioustumourcells David Dingli and Martin A. Nowak Cancer cells are generally infectious agents and be transmitted between individuals. The current view of cancer development is that normal cells are transformed into tumour cells by sequential mutations that activate cancer- promoting

Nowak, Martin A.

471

Journal of Theoretical Biology ] (  

E-Print Network [OSTI]

, and Uganda as of September 14, 2003 (CDC, 2003b; WHO, 2003a). Two different strains of the Ebola virus (Ebola-Zaire and the Ebola-Sudan) have been reported in those regions. Despite extensive search, the reservoir of the EbolaJournal of Theoretical Biology ] (

Chowell, Gerardo

472

Fish Biology Introduction  

E-Print Network [OSTI]

Lab 10: Fish Biology Introduction The effective management of fish populations requires knowledge of the growth rate of the fish. This requires determination of the age of fish to develop a relationship between the size and age of fish. For an inventory, this information provides insights to evaluate the potential

Jochem, Frank J.

473

Evolutionary biology of language  

Science Journals Connector (OSTI)

...Support, Non-U.S. Gov't Review | Animals Biological Evolution...exchange information, make plans, express new ideas and totally...their pay-o . This is the standard assumption of evolu- tionary...Eigen & Schuster 1979). Standard quasispecies theory has constant...

2000-01-01T23:59:59.000Z

474

Probabilistic Biological Network Alignment  

Science Journals Connector (OSTI)

Interactions between molecules are probabilistic events. An interaction may or may not happen with some probability, depending on a variety of factors such as the size, abundance, or proximity of the interacting molecules. In this paper, we consider ... Keywords: Probabilistic logic,Proteins,Network topology,Polynomials,Random variables,Topology,random graphs,Probabilistic biological networks,network alignment,neighborhood topology

Andrei Todor; Alin Dobra; Tamer Kahveci

2013-01-01T23:59:59.000Z

475

Work for Biology Teachers  

Science Journals Connector (OSTI)

... material devised for the A-level trials has crystallized out into a modest set of interrelated books and it is only regrettable that all could not have become available simultaneously because ... gain information for themselves and, in doing so, to get some understanding of the processes whereby biological knowledge is acquired. Each set of investigations is preceded by an explanatory ...

JOYCE VINNICOMBE

1970-11-07T23:59:59.000Z

476

Thermodynamics of Biological Synthesis  

Science Journals Connector (OSTI)

... SEVERAL selected topics of thermodynamics are of importance for the interpretation of the results of biochemical experiments. A closer ... ago there were still lively disputes among eminent scientists as to whether the laws of thermodynamics are strictly applicable to biological systems. Some suggested that evolution or man's intellect ...

HERBERT GUTFREUND

1957-08-03T23:59:59.000Z

477

ECOLOGY LABORATORY BIOLOGY 341  

E-Print Network [OSTI]

Page 1 ECOLOGY LABORATORY BIOLOGY 341 Fall Semester 2008 Bighorn Sheep Rams at Bison Range National ecological data; and 3) oral and written communication skills. Thus, these ecology labs, and statistical analyses appropriate for ecological data. A major goal of this class will be for you to gain

Vonessen, Nikolaus

478

BIOLOGY AND AQUATIC PLANTS  

E-Print Network [OSTI]

Handbook First published in the United States of America in 2009 by Aquatic Ecosystem Restoration plant management. The Aquatic Ecosystem Restoration Foundation (AERF) is pleased to bring you Biology for the environmentally and scientifically sound management, conservation and restoration of aquatic ecosystems. One

Jawitz, James W.

479

radiation.p65  

Office of Legacy Management (LM)

5 5 United States Department of Energy This fact sheet explains the potential health hazards associated with the radioactive decay of uranium and other radioactive elements found in ore and mill tailings. Potential Health Hazards of Radiation Man-made sources of radiation, most notably from medical uses and consumer products, contribute to the remaining radiation dose that individuals receive. A few household products, including smoke detectors, micro- wave ovens, and color televisions, emit small amounts of radiation. For most people, the benefits from using such products far outweigh the radiation risks. Radiation Dose Radiation is measured in various units. Individuals who have been exposed to radiation have received a radiation dose. Radiation dose to people is expressed in

480

Global methylation responses to low dose radiation exposure  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

methylation responses to low dose radiation exposure methylation responses to low dose radiation exposure Pamela J Sykes, Michelle R Newman, Benjamin J Blyth and Rebecca J Ormsby Haematology and Genetic Pathology, Flinders University and Medical Centre, Flinders Centre for Cancer Prevention and Control, Bedford Park, Adelaide, South Australia 5042 Australia. (pam.sykes@flinders.edu.au). Our goal is to study the mechanisms involved in biological responses to low doses of radiation in vivo in the dose range that is relevant to population and occupational exposures. At high radiation doses, DNA double-strand breaks are considered the critical lesion underlying the initiation of radiation-induced carcinogenesis. However, at the very low radiation doses relevant for the general public, the induction of DNA double-strand breaks

First Page Previous Page 1 2 3 4 5 6 7 8 9