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1

Molecular Mechanism Underlying Cellular Adaptive Response to Low Dose Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Mechanism Underlying Cellular Adaptive Response to Low Dose Radiation Mechanism Underlying Cellular Adaptive Response to Low Dose Radiation Colette A. Sacksteder § , DJ Black ‡ , Heather Smallwood § , David G. Camp II † , and Thomas C. Squier § § Cell Biology and Biochemistry; † Biological Sciences Division Pacific Northwest National Laboratory, Richland WA 99352 ‡ School of Biological Sciences, University of Missouri, Kansas City MO 64110 The goal of this research is to identify the molecular mechanisms by which cells adapt to low dose radiation exposure. Previously we have shown a radiation dependent increase of Calmodulin (CaM) in RAW 264.7 macrophages (RAW). Therefore we hypothesize that CaM and associated signaling complexes are sensors of low-dose radiation, resulting in alterations in energy metabolism and gene expression. The ultimate experimental goal

2

Biological Basis for Radiation Adaptive Responses that Protect Against  

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Basis for Radiation Adaptive Responses that Protect Against Basis for Radiation Adaptive Responses that Protect Against Bronchial Epithelial Cell Transformation Wenshu Chen Lovelace Respiratory Research Institute Abstract The major hypothesis in this project is that low-dose, low linear-energy-transfer (LET) radiation stimulates an adaptive response that protects cells from neoplastic transformation involving modulation of paracrine factors (e.g., cytokines), cell survival/death signaling pathways, and reprogramming of the epigenome. To test this hypothesis, a validated, sensitive in vitro transformation model and a media transfer method were used to study the mechanisms of low-LET gamma radiation activated natural protection (ANP) against chemical carcinogen-induced bronchial cell transformation. Immortalized human bronchial epithelial cell

3

Low Dose Radiation Research Program: Adaptive Response of Mouse Skin  

NLE Websites -- All DOE Office Websites (Extended Search)

Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Ionizing Radiation: Induction of NF-κB, MnSOD, 14-3-3ζ and Cyclin B1 Authors: Jian Jian Li, Kazi M. Ahmed, Ming Fan, Shaozhong Dong, Douglas R. Spitz, and Cheng-Rong Yu Institutions: Division of Molecular Radiobiology, Purdue University School of Health Sciences, West Lafayette, Indiana; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa; Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland Gene expression profiles demonstrate that a group of key stress-responsive genes are associated with radiation exposure and may contribute to cellular

4

Biological Basis for Radiation Adaptive Responses that Protect Against Bronchial Epithelial Cell Transformation  

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Basis for Radiation Adaptive Responses that Protect Against Bronchial Basis for Radiation Adaptive Responses that Protect Against Bronchial Epithelial Cell Transformation Wenshu Chen, Xiuling Xu, Lang Bai, Mabel T. Padilla, Carmen Tellez, Katherine M. Gott, Shuguang Leng, Julie A. Wilder, Steven A. Belinsky, Bobby R. Scott and Yong Lin, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108 The major hypothesis in this project is that low-dose, low linear-energy-transfer (LET) radiation stimulates an adaptive response that protects cells from neoplastic transformation involving modulation of paracrine factors (e.g., cytokines), cell survival/death signaling pathways, and reprogramming of the epigenome. To test this hypothesis, a validated, sensitive in vitro transformation model and a media transfer

5

{sub p}53-Dependent Adaptive Responses in Human Cells Exposed to Space Radiations  

Science Conference Proceedings (OSTI)

Purpose: It has been reported that priming irradiation or conditioning irradiation with a low dose of X-rays in the range of 0.02-0.1 Gy induces a p53-dependent adaptive response in mammalian cells. The aim of the present study was to clarify the effect of space radiations on the adaptive response. Methods and Materials: Two human lymphoblastoid cell lines were used; one cell line bears a wild-type p53 (wtp53) gene, and another cell line bears a mutated p53 (mp53) gene. The cells were frozen during transportation on the space shuttle and while in orbit in the International Space Station freezer for 133 days between November 15, 2008 and March 29, 2009. After the frozen samples were returned to Earth, the cells were cultured for 6 h and then exposed to a challenging X-ray-irradiation (2 Gy). Cellular sensitivity, apoptosis, and chromosome aberrations were scored using dye-exclusion assays, Hoechst33342 staining assays, and chromosomal banding techniques, respectively. Results: In cells exposed to space radiations, adaptive responses such as the induction of radioresistance and the depression of radiation-induced apoptosis and chromosome aberrations were observed in wtp53 cells but not in mp53 cells. Conclusion: These results have confirmed the hypothesis that p53-dependent adaptive responses are apparently induced by space radiations within a specific range of low doses. The cells exhibited this effect owing to space radiations exposure, even though the doses in space were very low.

Takahashi, Akihisa [Department of Biology, School of Medicine, Nara Medical University, Nara (Japan); Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency, Ibaraki (Japan); Su Xiaoming [Department of Biology, School of Medicine, Nara Medical University, Nara (Japan); Suzuki, Hiromi [Japan Space Forum, Tokyo (Japan); Space Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima (Japan); Omori, Katsunori [Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency, Ibaraki (Japan); Seki, Masaya; Hashizume, Toko [Space Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima (Japan); Advanced Engineering Services Company, Limited, Ibaraki (Japan); Shimazu, Toru [Japan Space Forum, Tokyo (Japan); Ishioka, Noriaki [Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency, Ibaraki (Japan); Space Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima (Japan); Iwasaki, Toshiyasu [Radiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of the Electric Power Industry of Japan, Tokyo (Japan); Ohnishi, Takeo, E-mail: tohnishi@naramed-u.ac.j [Department of Radiation Oncology, School of Medicine, Nara Medical University, Nara (Japan); Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency, Ibaraki (Japan)

2010-11-15T23:59:59.000Z

6

Mechanisms of Low-Dose and Adaptive Responses in Radiation Sensitive...  

NLE Websites -- All DOE Office Websites (Extended Search)

of mice. We have demonstrated that neighboring component cell types within the mammary gland can differ markedly in their molecular responses depending on the genetic background...

7

Adaptive multigroup radiation diffusion  

E-Print Network (OSTI)

This thesis describes the development and implementation of an algorithm for dramatically increasing the accuracy and reliability of multigroup radiation diffusion simulations at low group counts. This is achieved by ...

Williams, Richard B., Sc. D. Massachusetts Institute of Technology

2005-01-01T23:59:59.000Z

8

Study Shows Roles of Receptor, Thiol on Adaptive Response  

NLE Websites -- All DOE Office Websites (Extended Search)

Study Shows Roles of Receptor, Thiol on Adaptive Response Study Shows Roles of Receptor, Thiol on Adaptive Response Jeffrey Murley Jeffrey Murley, Ph.D. David Grdina, Ph.D. Low Dose program-supported scientists at The University of Chicago have gained more insight into adaptive protective responses indicating the role of oxidative stress, the role of reactive oxygen species (ROS), and the induction of SOD2 (manganese Superoxide Dismutase) activity. These changes are central to the production of adaptive protective responses. Why Study Adaptive Response? Exposing cells to low doses of ionizing radiation has been reported to elevate resistance to genomic damage when the same cells are subsequently exposed to a much higher dose of radiation. This phenomenon, called adaptive response, is characterized by an increase

9

A Critical Examination of the Adaptive Response for Cytogenetic Damagein Human Cells, and Insights into the Adaptive Response Mechanism  

NLE Websites -- All DOE Office Websites (Extended Search)

Critical Examination of the Adaptive Response for Cytogenetic Damage Critical Examination of the Adaptive Response for Cytogenetic Damage in Human Cells, and Insights into the Adaptive Response Mechanism Björn E. Rydberg, Torsten Groesser, Antoine Snijders, Kelly Trego, Ju Han, Do Yup Lee, Bahram Parvin, Trent Northen, Andrew J. Wyrobek, and Priscilla K. Cooper Berkeley Lab SFA P.I.: Gary Karpen Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 Goal: Task 1 of the Berkeley Lab SFA is designed to identify adaptive response (AR) mechanisms that may affect risk of developing radiation-induced cancer and to assess the linearity with dose of processes that influence mammary gland carcinogenesis. We use both in vitro and in vivo experimental systems in a parallelogram strategy. Our human cell culture

10

Adaptable radiation monitoring system and method  

DOE Patents (OSTI)

A portable radioactive-material detection system capable of detecting radioactive sources moving at high speeds. The system has at least one radiation detector capable of detecting gamma-radiation and coupled to an MCA capable of collecting spectral data in very small time bins of less than about 150 msec. A computer processor is connected to the MCA for determining from the spectral data if a triggering event has occurred. Spectral data is stored on a data storage device, and a power source supplies power to the detection system. Various configurations of the detection system may be adaptably arranged for various radiation detection scenarios. In a preferred embodiment, the computer processor operates as a server which receives spectral data from other networked detection systems, and communicates the collected data to a central data reporting system.

Archer, Daniel E. (Livermore, CA); Beauchamp, Brock R. (San Ramon, CA); Mauger, G. Joseph (Livermore, CA); Nelson, Karl E. (Livermore, CA); Mercer, Michael B. (Manteca, CA); Pletcher, David C. (Sacramento, CA); Riot, Vincent J. (Berkeley, CA); Schek, James L. (Tracy, CA); Knapp, David A. (Livermore, CA)

2006-06-20T23:59:59.000Z

11

Adaptive Implicit Non-Equilibrium Radiation Diffusion  

SciTech Connect

We describe methods for accurate and efficient long term time integra- tion of non-equilibrium radiation diffusion systems: implicit time integration for effi- cient long term time integration of stiff multiphysics systems, local control theory based step size control to minimize the required global number of time steps while control- ling accuracy, dynamic 3D adaptive mesh refinement (AMR) to minimize memory and computational costs, Jacobian Free Newton-Krylov methods on AMR grids for efficient nonlinear solution, and optimal multilevel preconditioner components that provide level independent solver convergence.

Philip, Bobby [ORNL; Wang, Zhen [ORNL; Berrill, Mark A [ORNL; Rodriguez Rodriguez, Manuel [ORNL; Pernice, Michael [Idaho National Laboratory (INL)

2013-01-01T23:59:59.000Z

12

Low Dose Responses in Human Cells and Molecular Mechanisms of Adaptation  

NLE Websites -- All DOE Office Websites (Extended Search)

Responses in Human Cells and Molecular Mechanisms of Adaptation Responses in Human Cells and Molecular Mechanisms of Adaptation Joe Gray Priscilla Cooper Lawrence Berkeley National Laboratory Abstract The radiation Adaptive Response (adaptation, or AR) is a well documented, although evidently highly variable, protective phenomenon in which exposures to low-dose or low-dose-rate ionizing radiation result in reduced deleterious effects of subsequent higher exposures. Protection has been reported against a variety of biologically important endpoints, but its variability as a function of cell and tissue type and its genetic control are not well understood. The adaptive response is predicted to result in a non-linear dose response for cancer risk in the low dose range. However, the molecular mechanism(s) remain unknown, and such information is

13

An adaptive radiation model for the origin of new gene functions  

E-Print Network (OSTI)

Foster, P.L. Adaptive radiation of a frameshift mutation inThe Ecology of Adaptive Radiation, (Oxford University Press,18 th , 2004) An adaptive radiation model for the origin of

Francino, M. Pilar

2004-01-01T23:59:59.000Z

14

Low Dose Radiation Research Program: Genetic Control of Repair and Adaptive  

NLE Websites -- All DOE Office Websites (Extended Search)

Repair and Adaptive Responses to Low-level DNA Damage Repair and Adaptive Responses to Low-level DNA Damage James E. Haber Brandeis University Why This Project In order to fully understand mechanisms resulting in effects of low dose, whole system rather than cells must be examined. Although not identical to mammalian systems, simple systems usually have many similarities and give direction for further study of more complex systems. We use the budding yeast, Saccharomyces cerevisiae, as a model system because it is easy to manipulate and its genome is simple and well characterized. Project Goals Examine mechanisms and effects of low dose radiation response for: Genetic recombination mechanisms that lead to genomic instability Genetic factors that affect individual susceptibility to low-dose radiation The adaptive response

15

A Critical Examination of the Adaptive Response for Cytogenetic Damage in  

NLE Websites -- All DOE Office Websites (Extended Search)

Critical Examination of the Adaptive Response for Cytogenetic Damage in Critical Examination of the Adaptive Response for Cytogenetic Damage in Human Cells, and Insights into the Adaptive Response Mechanism Björn E. Rydberg Lawrence Berkeley National Laboratory Abstract Goal: Task 1 of the Berkeley Lab SFA is designed to identify adaptive response (AR) mechanisms that may affect risk of developing radiation-induced cancer and to assess the linearity with dose of processes that influence mammary gland carcinogenesis. We use both in vitro and in vivo experimental systems in a parallelogram strategy. Our human cell culture model will elucidate the molecular mechanisms of the AR and investigate the relationships in target vs. non-target cells between a range of cancer-relevant endpoints potentially affected by adaptation such

16

Method of enhancing radiation response of radiation detection materials  

DOE Patents (OSTI)

The present invention is a method of increasing radiation response of a radiation detection material for a given radiation signal by first pressurizing the radiation detection material. Pressurization may be accomplished by any means including mechanical and/or hydraulic. In this application, the term "pressure" includes fluid pressure and/or mechanical stress.

Miller, Steven D. (Richland, WA)

1997-01-01T23:59:59.000Z

17

Effects of Radiation on Adaptive Immunity: Contact Hypersensitivity Model  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation on Adaptive Immunity: Contact Hypersensitivity Model Radiation on Adaptive Immunity: Contact Hypersensitivity Model Gregory Nelson Loma Linda University Abstract It has long been appreciated that cells of the immune system are radiosensitive and use apoptosis as the primary mechanism of cell death following injury. The hypervariability of the immunoglobulin superfamily of genes expressed in lymphoid cells also led to the appreciation of the nonhomologous end joining mechanism of DNA repair. Clinically, whole body irradiation is used in treatment of some lymphomas and as an immunosuppressive agent for bone marrow transplants. Inflammation at sites of radiotherapy is a common side effect. Many studies with radiation have addressed the changes in cell populations following radiation exposure and have shown a reproducible pattern of relative sensitivities amongst

18

Adaptive and reverse adaptive responses for chromosomal inversions...  

NLE Websites -- All DOE Office Websites (Extended Search)

a response which can protect from inversion induction within four hours of high dose irradiation. 0 1 2 3 4 5 6 0 0.01 1 1000 1000+0.01 1000+1 Dose (mGy) M e a n in v e r s io n fr...

19

Suppression of Tumorigenesis by Adaptive Response in Mice  

NLE Websites -- All DOE Office Websites (Extended Search)

of the adaptive response in mind, we have investigated the effects of low-dose-rate irradiation on the process of tumorigenesis at a whole body level in mice. Thymic lymphomas...

20

Radiation Response of Nano-scale Gold Foams  

Science Conference Proceedings (OSTI)

Our recent experiments and computer simulations focus on the radiation and mechanical response of nanoporous gold (NPG). Radiation tolerance was...

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Low Dose Radiation Research Program: Slide Shows  

NLE Websites -- All DOE Office Websites (Extended Search)

Dose Health Effects of Radiation Health Effects of Radiation Adaptive Response to Low Dose Radiation PDF Background Radiation PDF Bystander Effects PDF Dirty Bombs PDF DNA Damage...

22

The AROUND project: Adapting robotic disaster response to developing countries  

E-Print Network (OSTI)

The AROUND project: Adapting robotic disaster response to developing countries Alain Boucher1 constraints of developing countries. Keywords: Disaster response, Multi-Robot Systems, Cheap robotics, Spatial, in terms of frequency and devastating power, of natural disasters (par- ticularly in developing countries

Paris-Sud XI, Université de

23

Radiation-induced gene responses  

SciTech Connect

In the process of identifying genes that are differentially regulated in cells exposed to ultraviolet radiation (UV), we identified a transcript that was repressed following the exposure of cells to a combination of UV and salicylate, a known inhibitor of NF-kappaB. Sequencing this band determined that it has identify to lactate dehydrogenase, and Northern blots confirmed the initial expression pattern. Analysis of the sequence of the LDH 5` region established the presence of NF-kappaB, Sp1, and two Ap-2 elements; two partial AP- 1; one partial RE, and two halves of E-UV elements were also found. Electromobility shift assays were then performed for the AP-1, NF- kappaB, and E-UV elements. These experiments revealed that binding to NF-kappaB was induced by UV but repressed with salicylic acid; UV did not affect AP-1 binding, but salicylic acid inhibited it alone or following UV exposure; and E-UV binding was repressed by UV, and salicylic acid had little effect. Since the binding of no single element correlated with the expression pattern of LDH, it is likely that multiple elements govern UV/salicylate-mediated expression.

Woloschak, G.E.; Paunesku, T.; Shearin-Jones, P.; Oryhon, J.

1996-12-31T23:59:59.000Z

24

Neutron responsive self-powered radiation detector  

DOE Patents (OSTI)

An improved neutron responsive self-powered radiation detector is disclosed in which the neutron absorptive central emitter has a substantially neutron transmissive conductor collector sheath spaced about the emitter and the space between the emitter and collector sheath is evacuated.

Brown, Donald P. (Richland, WA); Cannon, Collins P. (Kennewick, WA)

1978-01-01T23:59:59.000Z

25

Distributed Demand Response and User Adaptation in Smart Grids  

E-Print Network (OSTI)

This paper proposes a distributed framework for demand response and user adaptation in smart grid networks. In particular, we borrow the concept of congestion pricing in Internet traffic control and show that pricing information is very useful to regulate user demand and hence balance network load. User preference is modeled as a willingness to pay parameter which can be seen as an indicator of differential quality of service. Both analysis and simulation results are presented to demonstrate the dynamics and convergence behavior of the algorithm.

Fan, Zhong

2010-01-01T23:59:59.000Z

26

Low Dose Radiation Research Program: Radiation Response in Normal...  

NLE Websites -- All DOE Office Websites (Extended Search)

genes. Using rigorous computational methods, we characterized the dose-dependent, radiation-induced gene expression of HSF-42, a primary cell culture. Our preliminary results...

27

Global methylation responses to low dose radiation exposure  

NLE Websites -- All DOE Office Websites (Extended Search)

methylation responses to low dose radiation exposure methylation responses to low dose radiation exposure Pamela J Sykes, Michelle R Newman, Benjamin J Blyth and Rebecca J Ormsby Haematology and Genetic Pathology, Flinders University and Medical Centre, Flinders Centre for Cancer Prevention and Control, Bedford Park, Adelaide, South Australia 5042 Australia. (pam.sykes@flinders.edu.au). Our goal is to study the mechanisms involved in biological responses to low doses of radiation in vivo in the dose range that is relevant to population and occupational exposures. At high radiation doses, DNA double-strand breaks are considered the critical lesion underlying the initiation of radiation-induced carcinogenesis. However, at the very low radiation doses relevant for the general public, the induction of DNA double-strand breaks

28

Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells  

Science Conference Proceedings (OSTI)

A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

Jian Li

2012-11-07T23:59:59.000Z

29

Low Dose Radiation Research Program: The Adaptive Response in...  

NLE Websites -- All DOE Office Websites (Extended Search)

Dolling,1 Ron E Mitchel,2 and Douglas R Boreham1 Institutions: 1McMaster University, Canada,2 Atomic Energy of Canada Limited, Canada The Trp53 gene is clearly associated with...

30

CRASH: A BLOCK-ADAPTIVE-MESH CODE FOR RADIATIVE SHOCK HYDRODYNAMICS-IMPLEMENTATION AND VERIFICATION  

SciTech Connect

We describe the Center for Radiative Shock Hydrodynamics (CRASH) code, a block-adaptive-mesh code for multi-material radiation hydrodynamics. The implementation solves the radiation diffusion model with a gray or multi-group method and uses a flux-limited diffusion approximation to recover the free-streaming limit. Electrons and ions are allowed to have different temperatures and we include flux-limited electron heat conduction. The radiation hydrodynamic equations are solved in the Eulerian frame by means of a conservative finite-volume discretization in either one-, two-, or three-dimensional slab geometry or in two-dimensional cylindrical symmetry. An operator-split method is used to solve these equations in three substeps: (1) an explicit step of a shock-capturing hydrodynamic solver; (2) a linear advection of the radiation in frequency-logarithm space; and (3) an implicit solution of the stiff radiation diffusion, heat conduction, and energy exchange. We present a suite of verification test problems to demonstrate the accuracy and performance of the algorithms. The applications are for astrophysics and laboratory astrophysics. The CRASH code is an extension of the Block-Adaptive Tree Solarwind Roe Upwind Scheme (BATS-R-US) code with a new radiation transfer and heat conduction library and equation-of-state and multi-group opacity solvers. Both CRASH and BATS-R-US are part of the publicly available Space Weather Modeling Framework.

Van der Holst, B.; Toth, G.; Sokolov, I. V.; Myra, E. S.; Fryxell, B.; Drake, R. P. [Department of Atmospheric, Oceanic and Space Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Powell, K. G. [Department of Aerospace Engineering, University of Michigan, Ann Arbor, MI 48109 (United States); Holloway, J. P. [Nuclear Engineering and Radiological Sciences, University of Michigan, Ann Arbor, MI 48109 (United States); Stout, Q. [Computer Science and Engineering, University of Michigan, Ann Arbor, MI 48109 (United States); Adams, M. L.; Morel, J. E. [Department of Nuclear Engineering, Texas A and M University, College Station, TX 77843 (United States); Karni, S. [Department of Mathematics, University of Michigan, Ann Arbor, MI 48109 (United States)

2011-06-01T23:59:59.000Z

31

Adaptive Responses to Low Dose/Low Dose-Rate γ-Rays in Normal Human Fibroblasts:  

NLE Websites -- All DOE Office Websites (Extended Search)

Responses to Low Dose/Low Dose-Rate γ-Rays in Normal Human Fibroblasts: Responses to Low Dose/Low Dose-Rate γ-Rays in Normal Human Fibroblasts: The Role of Oxidative Metabolism Edouard I. Azzam 1 , Sonia M. de Toledo 1 , Badri N. Pandey 1 , Perumal Venkatachalam 1 , Manuela Buoannano 1 , Zhi Yang 1 , Ling Li 3 , Donna M. Gordon 2 , Roger W. Howell 1 , Debkumar Pain 2 and Douglas R. Spitz 3 1 Department of Radiology, 2 Department of Pharmacology and Physiology, UMDNJ-New Jersey Medical School, Newark, NJ 3 Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA To investigate low dose/low dose-rate effects of low linear energy transfer ionizing radiation, we used γ-irradiated cells adapted to grow in three-dimensional architecture that mimics cell growth in vivo. We determined cellular, molecular and biochemical changes in these

32

A role for c-Abl/p53 pathway in radio-adaptive response  

NLE Websites -- All DOE Office Websites (Extended Search)

interaction c-Abl with the p53 pathway in regulation of the radio-adaptive response. Pilot experiments showed that c-Abl phosphorylates both MDM2 and MDMX, two negative...

33

Adaptive planning using megavoltage fan-beam CT for radiation therapy with testicular shielding  

Science Conference Proceedings (OSTI)

This study highlights the use of adaptive planning to accommodate testicular shielding in helical tomotherapy for malignancies of the proximal thigh. Two cases of young men with large soft tissue sarcomas of the proximal thigh are presented. After multidisciplinary evaluation, preoperative radiation therapy was recommended. Both patients were referred for sperm banking and lead shields were used to minimize testicular dose during radiation therapy. To minimize imaging artifacts, kilovoltage CT (kVCT) treatment planning was conducted without shielding. Generous hypothetical contours were generated on each 'planning scan' to estimate the location of the lead shield and generate a directionally blocked helical tomotherapy plan. To ensure the accuracy of each plan, megavoltage fan-beam CT (MVCT) scans were obtained at the first treatment and adaptive planning was performed to account for lead shield placement. Two important regions of interest in these cases were femurs and femoral heads. During adaptive planning for the first patient, it was observed that the virtual lead shield contour on kVCT planning images was significantly larger than the actual lead shield used for treatment. However, for the second patient, it was noted that the size of the virtual lead shield contoured on the kVCT image was significantly smaller than the actual shield size. Thus, new adaptive plans based on MVCT images were generated and used for treatment. The planning target volume was underdosed up to 2% and had higher maximum doses without adaptive planning. In conclusion, the treatment of the upper thigh, particularly in young men, presents several clinical challenges, including preservation of gonadal function. In such circumstances, adaptive planning using MVCT can ensure accurate dose delivery even in the presence of high-density testicular shields.

Yadav, Poonam [Department of Human Oncology, University of Wisconsin, Madison, Madison, WI (United States); Department of Medical Physics, University of Wisconsin, Madison, Madison, WI (United States); School of Advance Sciences, Vellore Institue of Technology University, Vellore, Tamil Nadu (India); Kozak, Kevin [Department of Human Oncology, University of Wisconsin, Madison, Madison, WI (United States); Tolakanahalli, Ranjini [Department of Human Oncology, University of Wisconsin, Madison, Madison, WI (United States); Department of Medical Physics, University of Wisconsin, Madison, Madison, WI (United States); Ramasubramanian, V. [School of Advance Sciences, Vellore Institue of Technology University, Vellore, Tamil Nadu (India); Paliwal, Bhudatt R. [Department of Human Oncology, University of Wisconsin, Madison, Madison, WI (United States); Department of Medical Physics, University of Wisconsin, Madison, Madison, WI (United States); University of Wisconsin, Riverview Cancer Centre, Wisconsin Rapids, WI (United States); Welsh, James S. [Department of Human Oncology, University of Wisconsin, Madison, Madison, WI (United States); Department of Medical Physics, University of Wisconsin, Madison, Madison, WI (United States); Rong, Yi, E-mail: rong@humonc.wisc.edu [Department of Human Oncology, University of Wisconsin, Madison, Madison, WI (United States); University of Wisconsin, Riverview Cancer Centre, Wisconsin Rapids, WI (United States)

2012-07-01T23:59:59.000Z

34

Mechanisms of radiation-induced gene responses  

Science Conference Proceedings (OSTI)

In the process of identifying genes differentially expressed in cells exposed ultraviolet radiation, we have identified a transcript having a 26-bp region that is highly conserved in a variety of species including Bacillus circulans, yeast, pumpkin, Drosophila, mouse, and man. When the 5` region (flanking region or UTR) of a gene, the sequence is predominantly in +/+ orientation with respect to the coding DNA strand; while in the coding region and the 3` region (UTR), the sequence is most frequently in the +/-orientation with respect to the coding DNA strand. In two genes, the element is split into two parts; however, in most cases, it is found only once but with a minimum of 11 consecutive nucleotides precisely depicting the original sequence. The element is found in a large number of different genes with diverse functions (from human ras p21 to B. circulans chitonase). Gel shift assays demonstrated the presence of a protein in HeLa cell extracts that binds to the sense and antisense single-stranded consensus oligomers, as well as to the double- stranded oligonucleotide. When double-stranded oligomer was used, the size shift demonstrated as additional protein-oligomer complex larger than the one bound to either sense or antisense single-stranded consensus oligomers alone. It is speculated either that this element binds to protein(s) important in maintaining DNA is a single-stranded orientation for transcription or, alternatively that this element is important in the transcription-coupled DNA repair process.

Woloschak, G.E.; Paunesku, T.

1996-10-01T23:59:59.000Z

35

7th International Workshop on Microbeam Probes of Cellular Radiation Response  

Science Conference Proceedings (OSTI)

The extended abstracts that follow present a summary of the Proceedings of the 7th International Workshop: Microbeam Probes of Cellular Radiation Response, held at Columbia Universitys Kellogg Center in New York City on March 1517, 2006. These International Workshops on Microbeam Probes of Cellular Radiation Response have been held regularly since 1993 (15). Since the first workshop, there has been a rapid growth (see Fig. 1) in the number of centers developing microbeams for radiobiological research, and worldwide there are currently about 30 microbeams in operation or under development. Single-cell/single-particle microbeam systems can deliver beams of different ionizing radiations with a spatial resolution of a few micrometers down to a few tenths of a micrometer. Microbeams can be used to addressquestions relating to the effects of low doses of radiation (a single radiation track traversing a cell or group of cells), to probe subcellular targets (e.g. nucleus or cytoplasm), and to address questions regarding the propagation of information about DNA damage (for example, the radiation-induced bystander effect). Much of the recent research using microbeams has been to study low-dose effects and non-targeted responses such as bystander effects, genomic instability and adaptive responses. This Workshop provided a forum to assess the current state of microbeam technology and current biological applications and to discuss future directions for development, both technological and biological. Over 100 participants reviewed the current state of microbeam research worldwide and reported on new technological developments in the fields of both physics and biology.

Brenner, David J.

2009-07-21T23:59:59.000Z

36

Adaptive Breast Radiation Therapy Using Modeling of Tissue Mechanics: A Breast Tissue Segmentation Study  

Science Conference Proceedings (OSTI)

Purpose: To validate and compare the accuracy of breast tissue segmentation methods applied to computed tomography (CT) scans used for radiation therapy planning and to study the effect of tissue distribution on the segmentation accuracy for the purpose of developing models for use in adaptive breast radiation therapy. Methods and Materials: Twenty-four patients receiving postlumpectomy radiation therapy for breast cancer underwent CT imaging in prone and supine positions. The whole-breast clinical target volume was outlined. Clinical target volumes were segmented into fibroglandular and fatty tissue using the following algorithms: physical density thresholding; interactive thresholding; fuzzy c-means with 3 classes (FCM3) and 4 classes (FCM4); and k-means. The segmentation algorithms were evaluated in 2 stages: first, an approach based on the assumption that the breast composition should be the same in both prone and supine position; and second, comparison of segmentation with tissue outlines from 3 experts using the Dice similarity coefficient (DSC). Breast datasets were grouped into nonsparse and sparse fibroglandular tissue distributions according to expert assessment and used to assess the accuracy of the segmentation methods and the agreement between experts. Results: Prone and supine breast composition analysis showed differences between the methods. Validation against expert outlines found significant differences (P<.001) between FCM3 and FCM4. Fuzzy c-means with 3 classes generated segmentation results (mean DSC = 0.70) closest to the experts' outlines. There was good agreement (mean DSC = 0.85) among experts for breast tissue outlining. Segmentation accuracy and expert agreement was significantly higher (P<.005) in the nonsparse group than in the sparse group. Conclusions: The FCM3 gave the most accurate segmentation of breast tissues on CT data and could therefore be used in adaptive radiation therapy-based on tissue modeling. Breast tissue segmentation methods should be used with caution in patients with sparse fibroglandular tissue distribution.

Juneja, Prabhjot, E-mail: Prabhjot.Juneja@icr.ac.uk [Joint Department of Physics, Institute of Cancer Research, Sutton (United Kingdom)] [Joint Department of Physics, Institute of Cancer Research, Sutton (United Kingdom); Harris, Emma J. [Joint Department of Physics, Institute of Cancer Research, Sutton (United Kingdom)] [Joint Department of Physics, Institute of Cancer Research, Sutton (United Kingdom); Kirby, Anna M. [Department of Academic Radiotherapy, Royal Marsden National Health Service Foundation Trust, Sutton (United Kingdom)] [Department of Academic Radiotherapy, Royal Marsden National Health Service Foundation Trust, Sutton (United Kingdom); Evans, Philip M. [Joint Department of Physics, Institute of Cancer Research, Sutton (United Kingdom)] [Joint Department of Physics, Institute of Cancer Research, Sutton (United Kingdom)

2012-11-01T23:59:59.000Z

37

Surface effects on the radiation response of nanoporous Au foams  

Science Conference Proceedings (OSTI)

We report on an experimental and simulation campaign aimed at exploring the radiation response of nanoporous Au (np-Au) foams. We find different defect accumulation behavior by varying radiation dose-rate in ion-irradiated np-Au foams. Stacking fault tetrahedra are formed when np-Au foams are irradiated at high dose-rate, but they do not seem to be formed in np-Au at low dose-rate irradiation. A model is proposed to explain the dose-rate dependent defect accumulation based on these results.

Fu, E. G.; Caro, M.; Wang, Y. Q.; Baldwin, K.; Caro, A. [Materials Science in Radiation and Dynamics Extremes, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Zepeda-Ruiz, L. A. [Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94551 (United States); Bringa, E. [CONICET and Instituto de Ciencias Basicas, Universidad Nacional de Cuyo, Mendoza 5500 (Argentina); Nastasi, M. [Nebraska Center for Energy Sciences Research, University of Nebraska-Lincoln, Lincoln, Nebraska 68508 (United States)

2012-11-05T23:59:59.000Z

38

Real-Time Molecular Monitoring of Chemical Environment in ObligateAnaerobes during Oxygen Adaptive Response  

DOE Green Energy (OSTI)

Determining the transient chemical properties of the intracellular environment canelucidate the paths through which a biological system adapts to changes in its environment, for example, the mechanisms which enable some obligate anaerobic bacteria to survive a sudden exposure to oxygen. Here we used high-resolution Fourier Transform Infrared (FTIR) spectromicroscopy to continuously follow cellular chemistry within living obligate anaerobes by monitoring hydrogen bonding in their cellular water. We observed a sequence of wellorchestrated molecular events that correspond to changes in cellular processes in those cells that survive, but only accumulation of radicals in those that do not. We thereby can interpret the adaptive response in terms of transient intracellular chemistry and link it to oxygen stress and survival. This ability to monitor chemical changes at the molecular level can yield important insights into a wide range of adaptive responses.

Holman, Hoi-Ying N.; Wozei, Eleanor; Lin, Zhang; Comolli, Luis R.; Ball, David. A.; Borglin, Sharon; Fields, Matthew W.; Hazen, Terry C.; Downing, Kenneth H.

2009-02-25T23:59:59.000Z

39

Self-adaptive and time-constrained data distribution paths for emergency response scenarios  

Science Conference Proceedings (OSTI)

Emergency response scenarios where team members coordinate impromptu towards the common human rescue goal are pushing to the extreme the demand for novel services fully aware of any (dynamically collected) relevant information describing the disaster ... Keywords: adaptive context data distribution, context data distribution, context-awareness, disaster areas

Mario Fanelli; Luca Foschini; Antonio Corradi; Azzedine Boukerche

2010-10-01T23:59:59.000Z

40

A Computational Model of Cellular Response to Modulated Radiation Fields  

Science Conference Proceedings (OSTI)

Purpose: To develop a model to describe the response of cell populations to spatially modulated radiation exposures of relevance to advanced radiotherapies. Materials and Methods: A Monte Carlo model of cellular radiation response was developed. This model incorporated damage from both direct radiation and intercellular communication including bystander signaling. The predictions of this model were compared to previously measured survival curves for a normal human fibroblast line (AGO1522) and prostate tumor cells (DU145) exposed to spatially modulated fields. Results: The model was found to be able to accurately reproduce cell survival both in populations which were directly exposed to radiation and those which were outside the primary treatment field. The model predicts that the bystander effect makes a significant contribution to cell killing even in uniformly irradiated cells. The bystander effect contribution varies strongly with dose, falling from a high of 80% at low doses to 25% and 50% at 4 Gy for AGO1522 and DU145 cells, respectively. This was verified using the inducible nitric oxide synthase inhibitor aminoguanidine to inhibit the bystander effect in cells exposed to different doses, which showed significantly larger reductions in cell killing at lower doses. Conclusions: The model presented in this work accurately reproduces cell survival following modulated radiation exposures, both in and out of the primary treatment field, by incorporating a bystander component. In addition, the model suggests that the bystander effect is responsible for a significant portion of cell killing in uniformly irradiated cells, 50% and 70% at doses of 2 Gy in AGO1522 and DU145 cells, respectively. This description is a significant departure from accepted radiobiological models and may have a significant impact on optimization of treatment planning approaches if proven to be applicable in vivo.

McMahon, Stephen J., E-mail: stephen.mcmahon@qub.ac.uk [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); Butterworth, Karl T. [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom)] [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); McGarry, Conor K. [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom) [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); Radiotherapy Physics, Northern Ireland Cancer Centre, Belfast Health and Social Care Trust, Northern Ireland (United Kingdom); Trainor, Colman [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom)] [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); O'Sullivan, Joe M. [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom) [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); Clinical Oncology, Northern Ireland Cancer Centre, Belfast Health and Social Care Trust, Belfast, Northern Ireland (United Kingdom); Hounsell, Alan R. [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom) [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom); Radiotherapy Physics, Northern Ireland Cancer Centre, Belfast Health and Social Care Trust, Northern Ireland (United Kingdom); Prise, Kevin M. [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom)] [Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland (United Kingdom)

2012-09-01T23:59:59.000Z

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Microsoft PowerPoint - Powerpoint_Adaptive.ppt [Compatibility Mode]  

NLE Websites -- All DOE Office Websites (Extended Search)

Response Response to Low Dose Radiation Adaptive Response Adaptive Response When large radiation When large radiation exposure is preceded by a ll " i kl " d h small "tickle" dose, the effect of the large dose is effect of the large dose is sometimes diminished The first time you go to the beach in the summer you don't usually spend 8 hours in summer, you don t usually spend 8 hours in the sun. You begin by being out an hour or d dd ddi i l i h i ki two and add additional time as their skin adapts to the sunny condition and develops protective mechanisms.... Adaptive Response Adaptive Response In some cases, cells also show an "adaptive response" to radiation, although researchers p , g are still trying to understand how the protective mechanisms work. Small doses p

42

Current Trends in Gamma Radiation Detection for Radiological Emergency Response  

SciTech Connect

Passive and active detection of gamma rays from shielded radioactive materials, including special nuclear materials, is an important task for any radiological emergency response organization. This article reports on the current trends and status of gamma radiation detection objectives and measurement techniques as applied to nonproliferation and radiological emergencies. In recent years, since the establishment of the Domestic Nuclear Detection Office by the Department of Homeland Security, a tremendous amount of progress has been made in detection materials (scintillators, semiconductors), imaging techniques (Compton imaging, use of active masking and hybrid imaging), data acquisition systems with digital signal processing, field programmable gate arrays and embedded isotopic analysis software (viz. gamma detector response and analysis software [GADRAS]1), fast template matching, and data fusion (merging radiological data with geo-referenced maps, digital imagery to provide better situational awareness). In this stride to progress, a significant amount of interdisciplinary research and development has taken placetechniques and spin-offs from medical science (such as x-ray radiography and tomography), materials engineering (systematic planned studies on scintillators to optimize several qualities of a good scintillator, nanoparticle applications, quantum dots, and photonic crystals, just to name a few). No trend analysis of radiation detection systems would be complete without mentioning the unprecedented strategic position taken by the National Nuclear Security Administration (NNSA) to deter, detect, and interdict illicit trafficking in nuclear and other radioactive materials across international borders and through the global maritime transportationthe so-called second line of defense.

Mukhopadhyay, S., Guss, P., Maurer, R.

2011-09-01T23:59:59.000Z

43

Scientists in a Changed Institutional Environment: Subjective Adaptation and Social Responsibility Norms in Russia  

Science Conference Proceedings (OSTI)

How do scientists react when the institutional setting in which they conduct their work changes radically? How do long-standing norms regarding the social responsibility of scientists fare? What factors influence whether scientists embrace or reject the new institutions and norms? We examine these questions using data from a unique survey of 602 scientists in Russia, whose science system experienced a sustained crisis and sweeping changes in science institutions following the collapse of the Soviet Union. We develop measures of how respondents view financing based on grants and other institutional changes in the Russian science system, as well as measures of two norms regarding scientists social responsibility. We find that the majority of scientists have adapted, in the sense that they hold positive views of the new institutions, but a diversity of orientations remains. Social responsibility norms are common among Russian scientists, but far from universal. The main correlates of adaptation are age and current success at negotiating the new institutions, though prospective success, work context, and ethnicity have some of the hypothesized associations. As for social responsibility norms, the main source of variation is age: younger scientists are more likely to embrace individualistic rather than socially-oriented norms.

Gerber, T P; Ball, D Y

2008-06-05T23:59:59.000Z

44

Role of Cell Cycle Regulation and MLH1, A Key DNA Mismatch Repair Protein, In Adaptive Survival Responses. Final Report  

SciTech Connect

Due to several interesting findings on both adaptive survival responses (ASRs) and DNA mismatch repair (MMR), this grant was separated into two discrete Specific Aim sets (each with their own discrete hypotheses). The described experiments were simultaneously performed.

David A. Boothman

1999-08-11T23:59:59.000Z

45

Role of ATM kinase in ionizing radiation induced DNA damage response...  

NLE Websites -- All DOE Office Websites (Extended Search)

ATM kinase in ionizing radiation induced DNA damage response in human neural stemprogenitor cells and differentiated cell types Adayabalam Balajee Columbia University Medical...

46

Low Dose Radiation Research Program: Mechanisms of Tissue Response...  

NLE Websites -- All DOE Office Websites (Extended Search)

whole body exposure to doses of 0.1 Gy to 5 Gy 60Co-g radiation in liver and mammary gland, which indicate that remodeling is a general and rapid consequence of irradiation but...

47

Mechanisms Underlying Cellular Responses to Low Doses/Low LET Ionizing Radiation in Primary Haemopoietic Cells.  

NLE Websites -- All DOE Office Websites (Extended Search)

Mechanisms Underlying Cellular Responses to Low Doses/Low LET Ionizing Radiation Mechanisms Underlying Cellular Responses to Low Doses/Low LET Ionizing Radiation in Primary Haemopoietic Cells. Munira Kadhim 1 , Stefania Militi 1 , Debbie Bowler 1 , Denise Macdonald 1 and Kevin Prise 2 1 Radiation and Genome Stability Unit, MRC, Harwell, Didcot, Oxon, OX11 0RD, UK 2 Gray Cancer Institute ,PO Box 100, Mount Vernon Hospital, Northwood, HA6 2JR, UK Because the human population is genetically heterogeneous, it is important to understand the role that heterogeneity may play in radiation response. Exposure to ionizing radiation can lead to a suite of changes, including increased mutation rate, delayed reproductive cell death, and delayed chromosomal aberrations, all of which are manifestations of the complex genomic instability (GI) phenotype. Following exposure to either high LET

48

Radiation hydrodynamics with Adaptive Mesh Refinement and application to prestellar core collapse. I Methods  

E-Print Network (OSTI)

Radiative transfer has a strong impact on the collapse and the fragmentation of prestellar dense cores. We present the radiation-hydrodynamics solver we designed for the RAMSES code. The method is designed for astrophysical purposes, and in particular for protostellar collapse. We present the solver, using the co-moving frame to evaluate the radiative quantities. We use the popular flux limited diffusion approximation, under the grey approximation (one group of photon). The solver is based on the second-order Godunov scheme of RAMSES for its hyperbolic part, and on an implicit scheme for the radiation diffusion and the coupling between radiation and matter. We report in details our methodology to integrate the RHD solver into RAMSES. We test successfully the method against several conventional tests. For validation in 3D, we perform calculations of the collapse of an isolated 1 M_sun prestellar dense core, without rotation. We compare successfully the results with previous studies using different models for r...

Commercon, Benoit; Audit, Edouard; Hennebelle, Patrick; Chabrier, Gilles

2011-01-01T23:59:59.000Z

49

Inter-System Software Adapter for Decision Support by Interfacing Disaster Response Platforms & Simulation Platforms  

Science Conference Proceedings (OSTI)

An inter-system adapter design is described which links the web service based DR NEP and WebSimP simulation platforms. The adapter enables the PSS Sincal electrical simulator to share results with the DR NEP which coordinates the data exchange among ... Keywords: disaster, management, interdependencies, infrastructure, web services

Jose Marti; Pranab Kini; Paul Lusina; Antonio Di Pietro; Vittorio Rosato; Baptiste Charnier; Wang Kui

2012-10-01T23:59:59.000Z

50

Origin, adaptive radiation and diversification of the Hawaiian lobeliads (Asterales: Campanulaceae)  

E-Print Network (OSTI)

provides corroboration for biogeo- graphic hypotheses, including (1) colonization of Kauai by Hawaiian that Platynini colonized the oldest high island of Kauai, with subsequent radiation throughout the present of Polynesia and Melanesia, plus New Zealand, New Caledonia, Australia, Indone- sia, the Philippines, and Japan

Sytsma, Kenneth J.

51

Low Dose Radiation Research Program: Biological Response of Individual...  

NLE Websites -- All DOE Office Websites (Extended Search)

Response of Individual Cells Following Electron Microbeam Irradiation L. A. Braby and J. R. Ford Texas A&M University, College Station Texas In recent years studies with low doses...

52

Chronic Low Dose Radiation Effects on Radiation Sensitivity  

NLE Websites -- All DOE Office Websites (Extended Search)

Chronic Low Dose Radiation Effects on Radiation Sensitivity Chronic Low Dose Radiation Effects on Radiation Sensitivity and Chromosome Instability Induction in TK6 Cells Schwartz J.L. 1 , Jordan R. 1 , Slovic J. 1 , Moruzzi A. 1 , Kimmel R. 2 , and Liber, H.L. 3 1 University of Washington, Seattle, WA; 2 Fred Hutchinson Cancer Research Center, Seattle, WA; 3 Colorado State University, Fort Collins, Colorado There are a number of cell responses that can be detected after low dose radiation exposures including the adaptive response, low dose hypersensitivity, and induced genomic instability. The relationship between these different phenomena is unknown. In this study, we measured adaptive responses, low dose hypersensitivity, and induced genomic instability in a human B-lymphoblastoid cell model, TK6, where we could genetically modify radiation responses by either over-expression of BCL-2 or deletion of TP53. TK6

53

Adaptive/Nonadaptive Proton Radiation Planning and Outcomes in a Phase II Trial for Locally Advanced Non-small Cell Lung Cancer  

SciTech Connect

Purpose: To analyze dosimetric variables and outcomes after adaptive replanning of radiation therapy during concurrent high-dose protons and chemotherapy for locally advanced non-small cell lung cancer (NSCLC). Methods and Materials: Nine of 44 patients with stage III NSCLC in a prospective phase II trial of concurrent paclitaxel/carboplatin with proton radiation [74 Gy(RBE) in 37 fractions] had modifications to their original treatment plans after re-evaluation revealed changes that would compromise coverage of the target volume or violate dose constraints; plans for the other 35 patients were not changed. We compared patients with adaptive plans with those with nonadaptive plans in terms of dosimetry and outcomes. Results: At a median follow-up of 21.2 months (median overall survival, 29.6 months), no differences were found in local, regional, or distant failure or overall survival between groups. Adaptive planning was used more often for large tumors that shrank to a greater extent (median, 107.1 cm{sup 3} adaptive and 86.4 cm{sup 3} nonadaptive; median changes in volume, 25.3% adaptive and 1.2% nonadaptive; P<.01). The median number of fractions delivered using adaptive planning was 13 (range, 4-22). Adaptive planning generally improved sparing of the esophagus (median absolute decrease in V{sub 70}, 1.8%; range, 0%-22.9%) and spinal cord (median absolute change in maximum dose, 3.7 Gy; range, 0-13.8 Gy). Without adaptive replanning, target coverage would have been compromised in 2 cases (57% and 82% coverage without adaptation vs 100% for both with adaptation); neither patient experienced local failure. Radiation-related grade 3 toxicity rates were similar between groups. Conclusions: Adaptive planning can reduce normal tissue doses and prevent target misses, particularly for patients with large tumors that shrink substantially during therapy. Adaptive plans seem to have acceptable toxicity and achieve similar local, regional, and distant control and overall survival, even in patients with larger tumors, vs nonadaptive plans.

Koay, Eugene J.; Lege, David [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Mohan, Radhe [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Komaki, Ritsuko; Cox, James D. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Chang, Joe Y., E-mail: jychang@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

2012-12-01T23:59:59.000Z

54

Low Dose Radiation Research Program: Low Dose Response of Respiratory Cells  

NLE Websites -- All DOE Office Websites (Extended Search)

Response of Respiratory Cells in Intact Tissues and Reconstituted Response of Respiratory Cells in Intact Tissues and Reconstituted Tissue John Ford Department of Nuclear Engineering Texas A & M University Why this Project? Using the well-established rat trachea model to test the hypothesis that normal respiratory epithelial cells transmit signals to neighboring cells in response to very low dose radiation exposure. Project Goals By comparing the responses shown by cells in these normal rodent respiratory tissues to those seen for human respiratory epithelial cells in reconstituted tissue constructs, it will be possible to better understand the responds in human respiratory cells in vivo. These studies will characterize responses after exposure to a variety of radiation types and dose distributions. Experimental Approach

55

Mechanisms underlying cellular responses of cells from haemopoeitic tissue to low dose-low LET radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

underlying cellular responses of cells from haemopoeitic underlying cellular responses of cells from haemopoeitic tissue to low dose-low LET radiation Munira Kadhim 1 , Sarah Irons 1 , Deborah Bowler 1 , Virginia Serra 1 , Stefania Militi 2 , Kim Chapman 1 1 Genomic Instability Research Group, School of Life Sciences, Oxford Brookes University, Gipsy Lane, Headington, Oxford, Oxfordshire, OX3 0BP, UK 2 Mammalian Genetics Unit, Medical Research Council Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK Radiation-induced responses at the cellular and whole body levels are influenced by genetic predisposition, with implications for environmental and potentially, diagnostic exposures. Currently, the extent to which genetic background play a role in the mechanisms and signalling pathways involved in radiation-induced

56

Transient Quantum Coherent Response to a Partially Coherent Radiation Field  

E-Print Network (OSTI)

The response of an arbitrary closed quantum system to a partially coherent electric field is investigated, with a focus on the transient coherences in the system. As a model we examine, both perturbatively and numerically, the coherences induced in a three level $V$ system. Both rapid turn-on and pulsed turn-on effects are investigated. The effect of a long and incoherent pulse is also considered, demonstrating that during the pulse the system shows a coherent response which reduces after the pulse is over. Both the pulsed scenario and the thermally broadened CW case approach a mixed state in the long time limit, with rates dictated by the adjacent level spacings and the coherence time of the light, and via a mechanism that is distinctly difference from traditional decoherence. These two excitation scenarios are also explored for a minimal "toy" model of the electronic levels in pigment protein complex PC645 by both a collisionally broadened CW laser and by a noisy pulse, where unexpectedly long transient coherence times are observed and explained. The significance of environmentally induced decoherence is noted.

Z. S. Sadeq; Paul Brumer

2013-12-10T23:59:59.000Z

57

An integrated genetics approach to systemic low-dose radiation responses  

NLE Websites -- All DOE Office Websites (Extended Search)

integrated genetics approach to systemic low-dose radiation responses integrated genetics approach to systemic low-dose radiation responses G. Huang 1 , Y. Huang 1 , D.H. Nguyen 1 , K. Bjornstad 1 , C. Rosen 1 , P. Chang 2 , R. DelRosario 3 , Do Yup Lee 1 , B. Bowen 1 , W. Reindl 1 , J. Mott 1 , A. Balmain 3 , M.H. Barcellos-Hoff 4 , Joe W Gray 1,5 , Mina Bissell 1 , Gary Karpen 1 , T. Northen 1 , E. A. Blakely 1 , J. H. Mao 1 1 Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 2 SRI International, Menlo Park, CA

58

Profiling of MnSOD Interaction Proteins in Low-Dose Radiation...  

NLE Websites -- All DOE Office Websites (Extended Search)

Proteins in Low-Dose Radiation Induced Adaptive Response Angela Eldridge 1 , Ming Fan 1 , Demet Candas 1 , Brett Chromy, and Jian Jian Li 1 1 Department of Radiation...

59

Cellular response to low dose radiation: Role of phosphatidylinositol-3 kinase like kinases  

Science Conference Proceedings (OSTI)

It is increasingly realized that human exposure either to an acute low dose or multiple chronic low doses of low LET radiation has the potential to cause different types of cancer. Therefore, the central theme of research for DOE and NASA is focused on understanding the molecular mechanisms and pathways responsible for the cellular response to low dose radiation which would not only improve the accuracy of estimating health risks but also help in the development of predictive assays for low dose radiation risks associated with tissue degeneration and cancer. The working hypothesis for this proposal is that the cellular mechanisms in terms of DNA damage signaling, repair and cell cycle checkpoint regulation are different for low and high doses of low LET radiation and that the mode of action of phosphatidylinositol-3 kinase like kinases (PIKK: ATM, ATR and DNA-PK) determines the dose dependent cellular responses. The hypothesis will be tested at two levels: (I) Evaluation of the role of ATM, ATR and DNA-PK in cellular response to low and high doses of low LET radiation in simple in vitro human cell systems and (II) Determination of radiation responses in complex cell microenvironments such as human EpiDerm tissue constructs. Cellular responses to low and high doses of low LET radiation will be assessed from the view points of DNA damage signaling, DNA double strand break repair and cell cycle checkpoint regulation by analyzing the activities (i.e. post-translational modifications and kinetics of protein-protein interactions) of the key target proteins for PI-3 kinase like kinases both at the intra-cellular and molecular levels. The proteins chosen for this proposal are placed under three categories: (I) sensors/initiators include ATM ser1981, ATR, 53BP1, gamma-H2AX, MDC1, MRE11, Rad50 and Nbs1; (II) signal transducers include Chk1, Chk2, FANCD2 and SMC1; and (III) effectors include p53, CDC25A and CDC25C. The primary goal of this proposal is to elucidate the differences in cellular defense mechanisms between low and high doses of low LET radiation and to define the radiation doses where the cellular DNA damage signaling and repair mechanisms tend to shift. This information is critically important to address and advance some of the low dose research program objectives of DOE. The results of this proposed study will lead to a better understanding of the mechanisms for the cellular responses to low and high doses of low LET radiation. Further, systematic analysis of the role of PIKK signaling pathways as a function of radiation dose in tissue microenvironment will provide useful mechanistic information for improving the accuracy of radiation risk assessment for low doses. Knowledge of radiation responses in tissue microenvironment is important for the accurate prediction of ionizing radiation risks associated with cancer and tissue degeneration in humans.

Balajee, A.S.; Meador, J.A.; Su, Y.

2011-03-24T23:59:59.000Z

60

NFkB in the Thiol-Induced Adaptive Response (A)  

NLE Websites -- All DOE Office Websites (Extended Search)

A) A) David Grdina The University of Chicago Abstract Exposure of cells to low non-lethal doses of ionizing radiation (≤ 10 cGy) or WR1065, the active free thiol form of amifostine, can induce pro-survival pathways that result in protection against the damaging effects of a 2 Gy dose of ionizing radiation. One such signaling pathway involves the activation of NFκB and the subsequent elevation of active manganese superoxide dismutase (SOD2). SOD2 is a mitochondrial matrix protein that serves as the primary mitochondrial defense against superoxide formation. Its primary function is to facilitate the dismutation of two molecules of superoxide anion (O2-) produced by normal respiratory processes or following exposure to ionizing radiation into water and hydrogen peroxide. To characterize the role of SOD2 in the radiation- and

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Low Dose Radiation Induced DNA Damage Signaling and Repair Responses in  

NLE Websites -- All DOE Office Websites (Extended Search)

Induced DNA Damage Signaling and Repair Responses in Induced DNA Damage Signaling and Repair Responses in Human 3-Dimensional Skin Model System Yanrong Su, Jarah Meador and Adayabalam S. Balajee Center for Radiological Research, College of Physicians and Surgeons, Columbia University, 630 West, 168th Street, New York, NY 10032. Exposure to ionizing radiation (IR) inflicts a wide variety of lesions in the genomic DNA. Among them, DNA double strand break (DSB) is considered to be the critical lesion for most of the deleterious radiation effects including carcinogenesis. Much of our knowledge on induction and repair kinetics of DSB has come from studies in two dimensional cell culture systems. However, the damage signaling and repair responses to DSB in tissue microenvironment are largely unknown. Knowledge of tissue responses to

62

The versatile E. coli adaptive response protein AlkB mitigates toxicity and mutagenicity of etheno-, ethano-, and methyl-modified bases in vivo  

E-Print Network (OSTI)

The Escherichia coli AlkB protein is an exceptionally versatile DNA repair enzyme. Its expression is induced upon exposure to alkylating agents as part of the Ada-mediated adaptive response. This member of the ac-ketoglu ...

Frick, Lauren Elizabeth

2007-01-01T23:59:59.000Z

63

Role of Interleukin-6 in the Radiation Response of Liver Tumors  

SciTech Connect

Purpose: To investigate the role of interleukin (IL)-6 in biological sequelae and tumor regrowth after irradiation for hepatic malignancy, which are critical for the clinical radiation response of liver tumors. Methods and Materials: The Hepa 1-6 murine hepatocellular cancer cell line was used to examine the radiation response by clonogenic assays and tumor growth delay in vivo. After irradiation in a single dose of 6 Gy in vitro or 15 Gy in vivo, biological changes including cell death and tumor regrowth were examined by experimental manipulation of IL-6 signaling. The effects of blocking IL-6 were assessed by cells preincubated in the presence of IL-6-neutralizing antibody for 24 hours or stably transfected with IL-6-silencing vectors. The correlations among tumor responses, IL-6 levels, and myeloid-derived suppressor cells (MDSC) recruitment were examined using animal experiments. Results: Interleukin-6 expression was positively linked to irradiation and radiation resistance, as demonstrated by in vitro and in vivo experiments. Interleukin-6-silencing vectors induced more tumor inhibition and DNA damage after irradiation. When subjects were irradiated with a sublethal dose, the regrowth of irradiated tumors significantly correlated with IL-6 levels and MDSC recruitment in vivo. Furthermore, blocking of IL-6 could overcome irradiation-induced MDSC recruitment and tumor regrowth after treatment. Conclusion: These data demonstrate that IL-6 is important in determining the radiation response of liver tumor cells. Irradiation-induced IL-6 and the subsequent recruitment of MDSC could be responsible for tumor regrowth. Therefore, treatment with concurrent IL-6 inhibition could be a potential therapeutic strategy for increasing the radiation response of tumors.

Chen, Miao-Fen, E-mail: miaofen@adm.cgmh.org.tw [Department of Radiation Oncology, Chang Gung Memorial Hospital, Chiayi, Taiwan (China) [Department of Radiation Oncology, Chang Gung Memorial Hospital, Chiayi, Taiwan (China); College of Medicine, Chang Gung University, Taiwan (China); Hsieh, Ching-Chuan [College of Medicine, Chang Gung University, Taiwan (China) [College of Medicine, Chang Gung University, Taiwan (China); Department of General Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan (China); Chen, Wen-Cheng [Department of Radiation Oncology, Chang Gung Memorial Hospital, Chiayi, Taiwan (China) [Department of Radiation Oncology, Chang Gung Memorial Hospital, Chiayi, Taiwan (China); College of Medicine, Chang Gung University, Taiwan (China); Lai, Chia-Hsuan [Department of Radiation Oncology, Chang Gung Memorial Hospital, Chiayi, Taiwan (China)] [Department of Radiation Oncology, Chang Gung Memorial Hospital, Chiayi, Taiwan (China)

2012-12-01T23:59:59.000Z

64

Low Dose Radiation Research Program: Mechanisms of Tissue Response to Low  

NLE Websites -- All DOE Office Websites (Extended Search)

Tissue Response to Low Dose Radiation Tissue Response to Low Dose Radiation Mary Helen Barcellos-Hoff Lawrence Berkeley National Laboratory Why This Project? In the past, the effects of ionizing radiation on humans has been attributed in great part to its ability to damage DNA, which transmits information from cell to cell, and generation to generation. Damaged DNA can lead to cell death or perpetuate the damage to daughter cells and to future generations. In addition to the information contained with the genome (i.e., DNA sequence), information directing cell behavior and tissue function is also stored outside the DNA. The success in cloning sheep from the DNA contained in the nucleus of an adult cell shows how important signals from the outside are in defining how the genome is expressed. This

65

Low Dose Radiation Research Program: Low Dose Response of Respiratory Cells  

NLE Websites -- All DOE Office Websites (Extended Search)

Low Dose Radiation Research Program: Low Dose Response of Respiratory Low Dose Radiation Research Program: Low Dose Response of Respiratory Cells in Intact Tissues and Reconstituted Tissue Constructs Authors: John Ford, Amy Maslowski, Alex Redd and Les Braby Institutions: Texas A&M University, College Station, TX We are developing a model of respiratory tissue using a perfusion culture system. We are using this system to quantify the effects of normal tissue architecture, and the interaction of epithelial cells with other cell types, on radiation-induced bystander effects. Tracheal tissue taken from young adult Fischer 344 rats is imbedded in a growth factor enriched agarose matrix. The chamber is designed to allow growth medium to periodically wash the epithelial surface of the tracheal lumen while maintaining the air-interface that is necessary for the normal

66

Annexin A2 Regulates A Low Dose-Specific Stress Response To Radiation.  

NLE Websites -- All DOE Office Websites (Extended Search)

Annexin A2 Regulates A Low Dose-Specific Stress Response To Radiation. Thomas J. Annexin A2 Regulates A Low Dose-Specific Stress Response To Radiation. Thomas J. Weber (PI), Greg J. Newton, Ryan D. Quesenberry, Janani I. Shutthanandan, Nikki Bollinger, Heather E. Engelmann and Lee K. Opresko. Cell Biology and Biochemistry Group, Pacific Northwest National Laboratory, Richland, WA 99354. Previous studies have demonstrated that JB6 cells release cell transforming paracrine factors following exposure to a low dose of radiation (10 cGy). Investigation of secreted proteins by SDS-Page and silver stain led to the identification of a 36 kDa band whose levels were increased in medium from irradiated cells, relative to sham controls. The 36 kDa band was identified as annexin A2 by mass spectrometry. Western blot analysis confirmed a dose-dependent increase in annexin A2 levels associated with medium from

67

Proteomic and Biochemical Studies of Human Mesenchymal Stem Cells in Response to Low Dose Ionizing Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Proteomic and Biochemical Studies of Human Mesenchymal Stem Cells Proteomic and Biochemical Studies of Human Mesenchymal Stem Cells in Response to Low Dose Ionizing Radiation Deok-Jin Jang 1 , Mingquan Guo 1 , Julia S.F.Chu 2 , Kyle T. Kurpinski 2 , Bjorn Rydberg 1 , Song Li 2 , and Daojing Wang 1 1. Life Sciences Division, Lawrence Berkeley National Lab, Berkeley, CA 94720 2. Department of Bioengineering, University of California, Berkeley, CA 94720 We will present data obtained during the first year of our DOE/NASA Low Dose Radiation Research program. We utilized a comprehensive approach including transcriptomics, proteomics, phosphoproteomics, and biochemistry to characterize human mesenchymal stem cells (MSCs) in response to low dose ionizing radiation. We first determined the cell survival, proliferation, and osteogenic differentiation of

68

Modular Systems Biology applied to TGFbeta and DNA Damage Response Signaling following Low Dose Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Modular Systems Biology applied to TGFbeta and DNA Damage Response Signaling following Modular Systems Biology applied to TGFbeta and DNA Damage Response Signaling following Low Dose Radiation Francis A. Cucinotta 1 , Yongfeng Li 2 , Minli Wang 2 , Claudio Carra 2 , Janice Pluth 3 , and Peter O'Neill 4 1 NASA Johnson Space Center, Houston, TX 2 U.S.R.A. Division of Life Sciences, Houston TX 3 Lawrence Berkeley National Laboratory, Berkeley CA 4 Oxford University, Oxford UK Abstract: Modular systems biology (MSB) describes the complexity of biological systems using well defined modules that represent distinct biological response pathways or sub-systems within pathways. We review mathematical concepts from control theory that can be used to identify and construct well defined modules for describing complex biological processes. The DNA damage response and TGFbeta/Smad signaling are two important response pathways following

69

Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages  

Science Conference Proceedings (OSTI)

Hypochlorous acid (HOCl) is potentially an important source of cellular oxidative stress. Human HOCl exposure can occur from chlorine gas inhalation or from endogenous sources of HOCl, such as respiratory burst by phagocytes. Transcription factor Nrf2 is a key regulator of cellular redox status and serves as a primary source of defense against oxidative stress. We recently demonstrated that HOCl activates Nrf2-mediated antioxidant response in cultured mouse macrophages in a biphasic manner. In an effort to determine whether Nrf2 pathways overlap with other stress pathways, gene expression profiling was performed in RAW 264.7 macrophages exposed to HOCl using whole genome mouse microarrays. Benchmark dose (BMD) analysis on gene expression data revealed that Nrf2-mediated antioxidant response and protein ubiquitination were the most sensitive biological pathways that were activated in response to low concentrations of HOCl (< 0.35 mM). Genes involved in chromatin architecture maintenance and DNA-dependent transcription were also sensitive to very low doses. Moderate concentrations of HOCl (0.35 to 1.4 mM) caused maximal activation of the Nrf2 pathway and innate immune response genes, such as IL-1{beta}, IL-6, IL-10 and chemokines. At even higher concentrations of HOCl (2.8 to 3.5 mM) there was a loss of Nrf2-target gene expression with increased expression of numerous heat shock and histone cluster genes, AP-1-family genes, cFos and Fra1 and DNA damage-inducible Gadd45 genes. These findings confirm an Nrf2-centric mechanism of action of HOCl in mouse macrophages and provide evidence of interactions between Nrf2, inflammatory, and other stress pathways.

Woods, Courtney G. [Division of Computational Biology, Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709 (United States); ExxonMobil Biomedical Sciences Incorporated, Annandale, NJ 08801 (United States); Fu Jingqi; Xue Peng; Hou Yongyong [Division of Translational Biology, Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709 (United States); School of Public Health, China Medical University, Shenyang 110001 (China); Pluta, Linda J.; Yang Longlong; Zhang Qiang; Thomas, Russell S.; Andersen, Melvin E. [Division of Computational Biology, Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709 (United States); Pi Jingbo [Division of Translational Biology, Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709 (United States)], E-mail: jpi@thehamner.org

2009-07-01T23:59:59.000Z

70

STOCHASTIC MODELS OF SPACE RADIATION DNA DAMAGE RESPONSES AND CANCER RISKS  

NLE Websites -- All DOE Office Websites (Extended Search)

STOCHASTIC MODELS OF SPACE RADIATION DNA DAMAGE STOCHASTIC MODELS OF SPACE RADIATION DNA DAMAGE RESPONSES AND CANCER RISKS Francis A. Cucinotta 1 , Janice M. Pluth 2 , Artem Ponomarev 3 , Shaowen Hu 3 , Jennifer Anderson 4 , Jane Harper 4 , and Peter O'Neill 4 1 NASA Lyndon B. Johnson Space Center, Houston TX, USA; 2 Lawrence Berkeley National Laboratory, Berkeley CA, USA; 3 U.S.R.A., Division of Life Sciences, Houston TX, USA; 4 MRC Radiation and Genome Stability Unit, Harwell, Didcot, UK Abstract: On space missions astronauts are exposed to a steady flux of galactic cosmic rays (GCR) consisting of high-energy protons and heavy ions. In the next decades long- term missions of up to 200 days to the Earth's moon and 1100 days to Mars are planed by NASA where cumulative doses will not be low (>100 mSv) albeit dose-

71

Low Dose Radiation Research Program: Low-Dose Dose-Response of  

NLE Websites -- All DOE Office Websites (Extended Search)

Low-Dose Dose-Response of Proliferating Human Cells Exposed to Low Low-Dose Dose-Response of Proliferating Human Cells Exposed to Low Dose Rate g-Radiation. Authors: Louise Enns,1 Michael Weinfeld,1 Albert Murtha,1 and Kenneth Bogen2 Institutions: 1Cross Cancer Institute and 2Lawrence Livermore National Laboratory. Clinical and environmental exposure to ionizing radiation rarely exceeds 200 cGy. To examine cell proliferation at early times (up to 5 days) post-irradiation, we are utilizing an assay in which single cells encapsulated within ~30- to 70-µm-diameter agarose gel microdrops (GMDs) are exposed and cultured for 4 days at 37°C, then analyzed by flow cytometry (FC). Clonogenic proliferation is measured as the fraction of occupied GMDs containing multicellular microcolonies after 4 days in culture. This assay was applied to human A549 lung cells exposed to gamma

72

Low Dose Radiation Research Program: James D. Tucker  

NLE Websites -- All DOE Office Websites (Extended Search)

Role of the Adaptive Response in determining health risks from in vivo exposures to low dose of ionizing radiation Tucker, J. Publications Christian, A.T., Patte, M.S., Attix,...

73

Th Cell Gene Expression and Function in Response to Low Dose and Acute Radiation  

SciTech Connect

FINAL TECHNICAL REPORT Supported by the Low Dose Radiation Research Program, Office of Science U.S. Department of Energy Grant No. DE-FG02-07ER64345 Project ID: 0012965 Award Register#: ER64345 Project Manager: Noelle F. Metting, Sc.D. Phone: 301-903-8309 Division SC-23.2 noelle.metting@science.doe.gov Submitted March 2012 To: https://www.osti.gov/elink/241.3.jsp Title: Th Cell Gene Expression and Function in Response to Low Dose and Acute Radiation PI: Daila S. Gridley, Ph.D. Human low dose radiation data have been derived primarily from studies of space and airline flight personnel, nuclear plant workers and others exposed occupationally, as well as victims in the vicinity of atomic bomb explosions. The findings remain inconclusive due to population inconsistencies and complex interactions among total dose, dose rate, radiation quality and age at exposure. Thus, safe limits for low dose occupational irradiation are currently based on data obtained with doses far exceeding the levels expected for the general population and health risks have been largely extrapolated using the linear-nonthreshold dose-response model. The overall working hypothesis of the present study is that priming with low dose, low-linear energy transfer (LET) radiation can ameliorate the response to acute high-dose radiation exposure. We also propose that the efficacy of low-dose induced protection will be dependent upon the form and regimen of the high-dose exposure: photons versus protons versus simulated solar particle event protons (sSPE). The emphasis has been on gene expression and function of CD4+ T helper (Th) lymphocytes harvested from spleens of whole-body irradiated C57BL/6 mice, a strain that provides the genetic background for many genetically engineered strains. Evaluations of the responses of other selected cells, tissues such as skin, and organs such as lung, liver and brain were also initiated (partially funded by other sources). The long-term goal is to provide information that will be useful in estimating human health risks due to radiation that may occur during exposures in the work environment, nuclear/radiological catastrophes, as well as radiotherapy. Several papers have been published, accepted for publication or are in preparation. A number of poster and oral presentations have been made at scientific conferences and workshops. Archived tissues of various types will continue to be evaluated via funding from other sources (the DoE Low Dose Radiation Research Program, Office of Science and this specific grant will be appropriately included in the Acknowledgements of all subsequent publications/presentations). A post-doc and several students have participated in this study. More detailed description of the accomplishments is described in attached file.

Daila S. Gridley, PhD

2012-03-30T23:59:59.000Z

74

Genome Wide Evaluation of Normal Human Tissue in Response to Controlled, In vivo Low-Dose Low LET Ionizing Radiation Exposure: Pathways and Mechanisms Final Report, September 2013  

SciTech Connect

During course of this project, we have worked in several areas relevant to low-dose ionizing radiation. Using gene expression to measure biological response, we have examined the response of human skin exposed in-vivo to radation, human skin exposed ex-vivo to radiation, and a human-skin model exposed to radiation. We have learned a great deal about the biological response of human skin to low-dose ionizing radiation.

Rocke, David M. [University of California Davis

2013-09-09T23:59:59.000Z

75

EMSL Research and Capability Development Proposals Nonlinear Radiation Response and Transport Properties in Scintillating Materials  

NLE Websites -- All DOE Office Websites (Extended Search)

Figure 1. Time-of-Flight (TOF) versus light Figure 1. Time-of-Flight (TOF) versus light output (L) of CsI:Tl to He + ions. The inset is an example where L=263 is determined for particles with certainty energy (TOF=840). The energy resolution can be determined by ∆L/L = 45/263. The light-energy dependence and energy resolution can be observed as the difference in curvature and dispersive of the data. EMSL Research and Capability Development Proposals Nonlinear Radiation Response and Transport Properties in Scintillating Materials Project start date: Spring 2007 EMSL Lead Investigator: Yanwen Zhang Deposition and Microfabrication, EMSL, PNNL Co-investigators: Vaithiyalingam Shutthanandan Deposition and Microfabrication, EMSL, PNNL Scintillation response has wide applications in the field of astronomy, medical physics, high-energy

76

Characterizing the radiation response of Cherenkov glass detectors with isotopic sources  

SciTech Connect

Abstract Cherenkov detectors are widely used for particle identification and threshold detectors in high-energy physics. Glass Cherenkov detectors that are sensitive to beta emissions originating from neutron activation have been demonstrated recently as a potential replacement for activation foils. In this work, we set the groundwork to evaluate large Cherenkov glass detectors for sensitivity to MeV photons through first understanding the measured response of small Cherenkov glass detectors to isotopic gamma-ray sources. Counting and pulse height measurements are acquired with reflected glass Cherenkov detectors read out with a photomultiplier tube. Simulation was used to inform our understanding of the measured results. This simulation included radioactive source decay, radiation interaction, Cherenkov light generation, optical ray tracing, and photoelectron production. Implications for the use of Cherenkov glass detectors to measure low energy gammaray response are discussed.

Hayward, J P [University of Tennessee, Knoxville (UTK); Hobbs, C. L. [University of Tennessee, Knoxville (UTK); Bell, Zane W [ORNL; Boatner, Lynn A [ORNL; Johnson, Rose E [ORNL; Ramey, Joanne Oxendine [ORNL; Jellison Jr, Gerald Earle [ORNL; Lillard, Cole R [ORNL; Ramey, Lucas A [ORNL

2012-01-01T23:59:59.000Z

77

Low Dose Radiation Response Curves, Networks and Pathways in Human Lymphoblastoid Cells Exposed from 1 to 10 cGy of Acute Gamma Radiation  

Science Conference Proceedings (OSTI)

We investigated the low dose dependency of the transcriptional response of human cells to characterize the shape and biological functions associated with the dose response curve and to identify common and conserved functions of low dose expressed genes across cells and tissues. Human lymphoblastoid (HL) cells from two unrelated individuals were exposed to graded doses of radiation spanning the range of 1-10 cGy were analyzed by transcriptome profiling, qPCR and bioinformatics, in comparison to sham irradiated samples. A set of {approx}80 genes showed consistent responses in both cell lines; these genes were associated with homeostasis mechanisms (e.g., membrane signaling, molecule transport), subcellular locations (e.g., Golgi, and endoplasmic reticulum), and involved diverse signal transduction pathways. The majority of radiation-modulated genes had plateau-like responses across 1-10 cGy, some with suggestive evidence that transcription was modulated at doses below 1 cGy. MYC, FOS and TP53 were the major network nodes of the low-dose response in HL cells. Comparison our low dose expression findings in HL cells with those of prior studies in mouse brain after whole body exposure, in human keratinocyte cultures, and in endothelial cells cultures, indicates that certain components of the low dose radiation response are broadly conserved across cell types and tissues, independent of proliferation status.

Wyrobek, A. J.; Manohar, C. F.; Nelson, D. O.; Furtado, M. R.; Bhattacharya, M. S.; Marchetti, F.; Coleman, M.A.

2011-04-18T23:59:59.000Z

78

Adaptation and adaptability : expectant design for resilience in coastal urbanity  

E-Print Network (OSTI)

What is the nature of and possibility for urban resiliency through adaptation? Adaptation implies responsiveness to phenomena that are disruptive to a system's functioning; it is a willful evolution in response to changed ...

Ruskeep, Laura A. Delaney (Laura Ashley Delaney)

2011-01-01T23:59:59.000Z

79

Metabolomic Response of Human Skin Tissue to Low Dose Ionizing Radiation  

Science Conference Proceedings (OSTI)

Understanding how human organs respond to ionizing radiation (IR) at a systems biology level and identifying biomarkers for IR exposure at low doses can help provide a scientific basis for establishing radiation protection standards. Little is known regarding the physiological responses to low dose IR at the metabolite level, which represents the end-point of biochemical processes inside cells. Using a full thickness human skin tissue model and GC-MS-based metabolomics analysis, we examined the metabolic perturbations at three time points (3, 24 and 48 hr) after exposure to 3, 10 and 200 cGy of X-rays. PLS-DA score plots revealed dose- and time-dependent clustering between sham and irradiated groups. Importantly, a comparable number of metabolites were detected to have significant change 48 hr after exposure to 3 and 10 cGy of irradiation, when compared with the high dose of 200 cGy. Biochemical pathway analysis showed perturbations to DNA/RNA damage and repair, lipid and energy metabolisms, even at low doses of IR.

Hu, Zeping; Kim, Young-Mo; Sowa, Marianne B.; Robinson, Robert J.; Gao, Xiaoli; Metz, Thomas O.; Morgan, William F.; Zhang, Qibin

2012-05-18T23:59:59.000Z

80

Adaptive sampler  

DOE Patents (OSTI)

An adaptive data compression device for compressing data having variable frequency content, including a plurality of digital filters for analyzing the content of the data over a plurality of frequency regions, a memory, and a control logic circuit for generating a variable rate memory clock corresponding to the analyzed frequency content of the data in the frequency region and for clocking the data into the memory in response to the variable rate memory clock.

Watson, Bobby L. (Idaho Falls, ID); Aeby, Ian (Fremont, CA)

1982-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Adaptive sampler  

DOE Patents (OSTI)

An adaptive data compression device for compressing data is described. The device has a frequency content, including a plurality of digital filters for analyzing the content of the data over a plurality of frequency regions, a memory, and a control logic circuit for generating a variable rate memory clock corresponding to the analyzed frequency content of the data in the frequency region and for clocking the data into the memory in response to the variable rate memory clock.

Watson, B.L.; Aeby, I.

1980-08-26T23:59:59.000Z

82

Radiators  

SciTech Connect

A heat-exchange radiator is connected to a fluid flow circuit by a connector which provides one member of an interengageable spigot and socket pair for push-fit, fluid-tight, engagement between the connector and the radiator, with latching formations at least one of which is resilient. Preferably the connector carries the spigot which tapers and engages with a socket of corresponding shape, the spigot carrying an O-ring seal and either latching fingers or a resilient latching circlip.

Webster, D. M.

1985-07-30T23:59:59.000Z

83

Low Dose Radiation Research Program: Research Institutions  

NLE Websites -- All DOE Office Websites (Extended Search)

Institutions Institutions Lovelace Respiratory Research Institute Biological Bases for Radiation Adaptive Responses in the Lung-Lovelace Respiratory Research Institute, Albuquerque, NM USA Contact: Dr. Bobby R. Scott Program Objective Our research focuses on elucidating the biological bases for radiation adaptive responses in the lung and for suppressing lung cancer, and to use the knowledge gained to produce an improved systems-biology-based, risk model for lung cancer induction by low-dose, low linear-energy-transfer (LET) radiation. Research was initiated in October 2009. This research should help foster a new era of low-dose radiation risk/benefit assessment. It will have important implications for possible use of low-dose diagnostic radiation (e.g., X-rays) in cancer therapy. It

84

Low Dose Radiation Research Program: Regulation of NF-kB and MnSOD in Low  

NLE Websites -- All DOE Office Websites (Extended Search)

NF-kB and MnSOD in Low Dose Radiation-Induced Adaptive NF-kB and MnSOD in Low Dose Radiation-Induced Adaptive Responses in Mouse and Human Skin Cells Jian Jian Li School of Health Sciences, Purdue University West Lafayette, Indiana Why this Project? To determine if low dose ionizing radiation-induced adaptive responses in skin cells are mediated by activation of signaling networks. Project Goals To evaluate the signaling networks involving transcription factor NF-kB and the mitochondrial antioxidant protein MnSOD. To determine if NF-kB is activated by low dose radiation in vivo. To determine if NF-kB activation is critical in the pathways that produce adaptive responses. Experimental Approach Cells transfected with NF-kB luciferase responder genes will be used to define a dose-response relationship for activation of the NF-kB gene. NF-kB

85

Low Dose Radiation Program: Workshop VI Abstracts  

NLE Websites -- All DOE Office Websites (Extended Search)

Workshop VI Principal Investigator and Abstracts Workshop VI Principal Investigator and Abstracts Anderson, Carl Whole Genome Analysis of Functional Protein Binding Sites and DNA Methylation: Application to p53 and Low Dose Ionizing Radiation. Averbeck, Dietrich Cellular Responses at Low Doses of Ionizing Radiation. Azzam, Edouard Adaptive Responses to Low Dose/Low Dose-Rate ?-Rays in Normal Human Fibroblasts: The Role of Oxidative Metabolism. Bailey, Susan The Role of Telomere Dysfunction in Driving Genomic Instability. Balajee, Adayabalam Low Dose Radiation Induced DNA Damage Signaling and Repair Responses in Human 3-Dimensional Skin Model System. Barcellos-Hoff, Mary Helen Imaging Bioinformatics for Mapping Multidimensional Responses. Barcellos-Hoff, Mary Helen Biological Response to Radiation Mediated through the Microenvironment and

86

An adaptive approach to metal artifact reduction in helical computed tomography for radiation therapy treatment planning: Experimental and clinical studies  

SciTech Connect

Purpose: In this article, an approach to metal artifact reduction is proposed that is practical for clinical use in radiation therapy. It is based on a new interpolation scheme of the projections associated with metal implants in helical computed tomography (CT) scanners. Methods and Materials: A three-step approach was developed consisting of an automatic algorithm for metal implant detection, a correction algorithm for helical projections, and a new, efficient algorithm for projection interpolation. The modified raw projection data are transferred back to the CT scanner device where CT slices are regenerated using the built-in reconstruction operator. The algorithm was tested on a CT calibration phantom in which the density of inserted objects are known and on clinical prostate cases with two hip prostheses. The results are evaluated using the CT number and shape of the objects. Results: The validations on a CT calibration phantom with various inserts of known densities show that the algorithm improved the overall image quality by restoring the shape and the representative CT number of the objects in the image. For the clinical hip replacement cases, a large fraction of the bladder, rectum, and prostate that were not visible on the original CT slices were recovered using the algorithm. Precise contouring of the target volume was thus feasible. Without this enhancement, physicians would have drawn bigger margins to be sure to include the target and, at the same time, could have prescribed a lower dose to keep the same level of normal tissue toxicity. Conclusions: In both phantom experiment and patient studies, the algorithm resulted in significant artifact reduction with increases in the reliability of planning procedure for the case of metallic hip prostheses. This algorithm is now clinically used as a preprocessing before treatment planning for metal artifact reduction.

Yazdia, Mehran [Departement de radio-onoclogie and Centre de Recherche en Cancerologie de l' Universite Laval, Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec (Canada); Gingras, Luc [Departement de radio-onoclogie and Centre de Recherche en Cancerologie de l' Universite Laval, Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec (Canada); Departement de Physique, Genie Physique et d' Optique, Universite Laval, Quebec City, Quebec (Canada); Beaulieu, Luc [Departement de radio-onoclogie and Centre de Recherche en Cancerologie de l' Universite Laval, Hotel-Dieu de Quebec, Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec (Canada) and Departement de Physique, Genie Physique et d' Optique, Universite Laval, Quebec City, Quebec (Canada)]. E-mail: beaulieu@phy.ulaval.ca

2005-07-15T23:59:59.000Z

87

EFFECTS OF triIODOTHYRONINE IN ALTERING THE RESPONSE OF KIDNEYS TO COBALT- 60 RADIATION  

SciTech Connect

The fear of inducing radiation nephritis restricts the amount of radiation delivered to retroperitonieal tumors. If this radiation injury could be modified, the therapist would then be less fearful of possibly inducing this often fatal complication. Since triiodothyronine has proved beneficial in reducing radiation injury of the skin and subcutaneous tissues, the effects of this compound were elvaluated following production of radiation injuiy in rabbit kidneys. Surprisingly, triiodothyronine did not favorably alter the reaction, but made it worse. The reason for this variance with the effects previously reported in skin is not certain. Tissue specificity or difference in vascularity may be important factors. The irradiated skin of the triiodothyroninetreated animals showed slightly less histologic alteration than the irradiated skin of the control animals. This tends to confirm the work of Glicksman and associates. (auth)

Caldwell, W.L.; Thomassen, R.W.; Bosch, A.

1963-10-01T23:59:59.000Z

88

Equilibrium Response of an AtmosphereMixed Layer Ocean Model to Different Radiative Forcing Agents: Global and Zonal Mean Response  

Science Conference Proceedings (OSTI)

The equilibrium response to various forcing agents, including CO2, solar irradiance, tropospheric ozone, black carbon, organic carbon, sulfate, and volcanic aerosols, is investigated using an atmospheric general circulation model coupled to a ...

Masakazu Yoshimori; Anthony J. Broccoli

2008-09-01T23:59:59.000Z

89

Low Dose Radiation Research Program: Gregory A. Kimmel  

NLE Websites -- All DOE Office Websites (Extended Search)

Gregory A. Kimmel Gregory A. Kimmel Pacific Northwest National Laboratory Past Project A Novel Spatially Resolved Cell Irradiator to Study Bystander and Adaptive Responses to Low-LET Radiation. Technical Abstracts 2002 Workshop: Spatially Resolved Single Cell Irradiator to Study Bystander Responses to Low LET Radiation. Resat, M.S., Kimmel, G.A., Miller, J.H., McDonald, J.C., Murphy, M.K., Strom, D.J., Thrall, B.D., and Colson, S.D. 2001 Workshop: Spatially Resolved Single Cell Irradiator to Study Bystander Responses to Low LET Radiation. Resat, M.S., Kimmel, G.A., Miller, J.H., McDonald, J.C., Murphy, M.K., Strom, D.J., Thrall, B.D., Metting, N.F., and Colson, S.D 1999 Workshop: A Novel, Spatially Resolved Cell Irradiator to Study Bystander and Adaptive Responses to Low-LET Radiation.

90

Low dose radiation and cancer in A-bomb survivors: latency and non-linear dose-response in the 195090 mortality cohort  

E-Print Network (OSTI)

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background: Analyses of Japanese A-bomb survivors ' cancer mortality risks are used to establish recommended annual dose limits, currently set at 1 mSv (public) and 20 mSv (occupational). Do radiation doses below 20 mSv have significant impact on cancer mortality in Japanese A-bomb survivors, and is the dose-response linear? Methods: I analyse stomach, liver, lung, colon, uterus, and all-solid cancer mortality in the 0 20 mSv colon dose subcohort of the 195090 (grouped) mortality cohort, by Poisson regression using a time-lagged colon dose to detect latency, while controlling for gender, attained age, and age-atexposure. I compare linear and non-linear models, including one adapted from the cellular bystander effect for ? particles. Results: With a lagged linear model, Excess Relative Risk (ERR) for the liver and all-solid cancers is significantly positive and several orders of magnitude above extrapolations from the Life Span Study Report 12 analysis of the full cohort. Non-linear models are strongly superior to the linear model for the stomach (latency 11.89 years), liver (36.90), lung (13.60) and all-solid (43.86) in fitting

Greg Dropkin; Greg Dropkin

2007-01-01T23:59:59.000Z

91

A study on sensing and adaptation in Dictyostelium discoideum. Guanosine Y,5'-phosphate~accumulation and light scattering responses  

E-Print Network (OSTI)

ABSTRACT Cells of Dictyostelium discoideum respond to extracellular cyclic AMP with marked changes in intracellular cyclic GMP levels and light scattering. In this work, defined temporal increases in cyclic AMP were produced by the continuous addition of cyclic AMP to agitated suspensions of cells; concomitant hydrolysis of cyclic AMP by the cells subsequently established a constant, steady state concentration. The cells responded to the initial increase in extracellular cyclic AMP with a rapid increase in the intracellular cyclic GMP concentration and a rapid decrease in light scattering. At cyclic AMP input rates of 0.5-5 nM x s-1, the fast reactions of cyclic GMP and light scattering had already relaxed while the cyclic AMP concentration in the cell suspension was still increasing. The cells responded to constant concentrations of cyclic AMP with constant elevated cyclic GMP concentrations and constant decreased levels of light scattering. Our results are consistent with the existence of two types of perception systems, one of which adapts to constant stimuli and one of which does not adapt. Cells of Dictyostelium discoideum respond chemotactically to cyclic AMP (1, 2) as well as to folio acid (3, 4) and pterin (4). During differentiation from the growth phase to the aggregation-competent

Bernd Wurster; Ursula Butz

1983-01-01T23:59:59.000Z

92

Seasonal Changes in Solar Radiation and Relative Humidity in Europe in Response to Global Warming  

Science Conference Proceedings (OSTI)

Future seasonal changes in surface incident solar radiation and relative humidity (RH) over Europe and adjacent ocean areas were assessed based on phase 3 of the Coupled Model Intercomparison Project (CMIP3) model ensemble. Under the A1B scenario, ...

Kimmo Ruosteenoja; Petri Risnen

2013-04-01T23:59:59.000Z

93

The Response of a Spectral General Circulation Model to Refinements in Radiative Processes  

Science Conference Proceedings (OSTI)

We present here results and analyses of a series of numerical experiments performed with a spectral general circulation model (GCM). The purpose of the GCM experiments is to examine the role of radiation/cloud processes in the general circulation ...

V. Ramanathan; Eric J. Pitcher; Robert C. Malone; Maurice L. Blackmon

1983-03-01T23:59:59.000Z

94

In vitro models for investigating keratinocyte responses to ultraviolet B radiation.  

E-Print Network (OSTI)

??This thesis describes the use of 2- and 3-dimensional cell-based models for studying how skin cells respond to ultraviolet radiation. These methods were used to (more)

Fernandez, Tara L.

2013-01-01T23:59:59.000Z

95

Observed Perturbations of the Earth's Radiation Budget: A Response to the El Chichn Stratospheric Aerosol Layer?  

Science Conference Proceedings (OSTI)

The Earth Radiation Budget experiment, launched aboard the Nimbus-7 polar-orbiting spacecraft in late 1978, has now taken over seven years of measurements. The dataset, which is global in coverage, consists of the individual components of the ...

Philip E. Ardanuy; H. Lee Kyle

1986-04-01T23:59:59.000Z

96

Mitochondrial-Derived Oxidants and Cellular Responses to Low Dose/Low LET Ionizing Radiation  

SciTech Connect

Exposure to ionizing radiation results in the immediate formation of free radicals and other reactive oxygen species (ROS). It has been assumed that the subsequent injury processes leading to genomic instability and carcinogenesis following radiation, derive from the initial oxidative damage caused by these free radicals and ROS. It is now becoming increasingly obvious that metabolic oxidation/reduction (redox) reactions can be altered by irradiation leading to persistent increases in steady-state levels of intracellular free radicals and ROS that contribute to the long term biological effects of radiation exposure by causing chronic oxidative stress. The objective during the last period of support (DE-FG02-05ER64050; 5/15/05-12/31/09) was to determine the involvement of mitochondrial genetic defects in metabolic oxidative stress and the biological effects of low dose/low LET radiation. Aim 1 was to determine if cells with mutations in succinate dehydrogenase (SDH) subunits C and D (SDHC and SDHD in mitochondrial complex II) demonstrated increases in steady-state levels of reactive oxygen species (ROS; O2- and H2O2) as well as demonstrating increased sensitivity to low dose/low LET radiation (10 cGy) in cultured mammalian cells. Aim #2 was to determine if mitochondrially-derived ROS contributed to increased sensitivity to low dose/low LET radiation in mammalian cells containing mutations in SDH subunits. Aim #3 was to determine if a causal relationship existed between increases in mitochondrial ROS production, alterations in electron transport chain proteins, and genomic instability in the progeny of irradiated cells. Evidence gathered in the 2005-2009 period of support demonstrated that mutations in genes coding for mitochondrial electron transport chain proteins (ETC); either Succinate Dehydrogenase (SDH) subunit C (SDHC) or subunit D (SDHD); caused increased ROS production, increased genomic instability, and increased sensitivity to low dose/low LET radiation that could be mitigated by over expression of the H2O2 metabolizing enzyme, catalase, and/or the mitochondrial form of superoxide dismutase (MnSOD). Furthermore, using radiation-induced genomically unstable cells, it was shown that steady-state levels of H2O2 were significantly elevated for many cell generations following exposure, catalase suppressed the radiation-induced mutator phenotype when added long after radiation exposure, unstable clones showed evidence of mitochondrial dysfunction some of which was characterized by improper assembly of SDH subunits (particularly subunit B), and chemical inhibitors of SDH activity could decrease steady-state levels of H2O2 as well as mutation frequency. These results support the hypotheses that 1) SDH mutations could contribute to transformation by inducing genomic instability and a mutator phenotype via increasing steady-state levels of ROS; 2) metabolic sources of O2- and H2O2 play a significant role in low dose radiation induced injury and genomic instability; and 3) increased mutation rates in irradiated mammal cells can be suppressed by scavengers of H2O2 (particularly catalase) long after radiation exposure. Overall the results obtained during this period of support provide clear evidence in support of the hypothesis that abnormal oxidative metabolism in mitochondria that result in increases in steady-sate levels of H2O2 and other ROS are capable of significantly contributing to radiation-induced mutator phenotypes in mammalian cells.

Spitz, Douglas R.

2009-11-09T23:59:59.000Z

97

Low Dose Radiation Response Curves, Networks and Pathways in Human Lymphoblastoid Cells Exposed from 1 to 10 cGy of Acute Gamma Radiation  

E-Print Network (OSTI)

R.B. Mikkelsen, Ionizing radiation-induced, mitochondria-W.K. Rorrer, P.B. Chen, Radiation-induced proliferation ofresponse genes to ionizing radiation in human lymphoblastoid

Wyrobek, A. J.

2011-01-01T23:59:59.000Z

98

The Circadian Rhythm, A Continuous Transcription-Translation Feedback Loop, Contributes to Low-Dose Radiation-Induced Radioadaptive Response  

NLE Websites -- All DOE Office Websites (Extended Search)

The Circadian Rhythm, A Continuous Transcription-Translation Feedback Loop, Contributes to Low-Dose Radiation-Induced Radioadaptive Response Aris Alexandrou and Jian Jian Li Department of Radiation Oncology, the University of California Davis, Sacramento, California, 95817 The initiation of the circadian rhythm field occurred when the Takahashi group defined a mutation in the mouse gene "Clock" and cloned the circadian locomotor output cycles kaput (Clock) in the mid- 1990's (1-3). Currently more than a dozen clock genes have been identified (3-4). Disruptions in the circadian rhythm via changes in environmental conditions, such as, diet, temperature, and night/day hours lead to the pathogenesis of a multitude of diseases, such as, cancer, diabetes mellitus,

99

A Functional Interaction of the C-Abl and Heat Shock Response Pathways in  

NLE Websites -- All DOE Office Websites (Extended Search)

Functional Interaction of the C-Abl and Heat Shock Response Pathways in Functional Interaction of the C-Abl and Heat Shock Response Pathways in Radio-Adaptive Response Hang Su & Zhi-Min Yuan University of Texas Health Science Center at San Antonio Abstract A functional interaction of the c-Abl and heat shock response pathways in radio-adaptive response Hang Su & Zhi-Min Yuan. Department of Radiation Oncology, UTHSCSA The radio-adaptive response, i.e. a low dose of radiation can protect cells and organisms from the effects of a subsequent higher dose, is a phenomenon that has been widely recognized. However, mechanisms underlying such radiation hormesis remain largely unclear. Our preliminary studies have uncovered a crucial role for the c-Abl tyrosine kinase as evidenced by that c-Abl-deficient cells exhibited a compromised

100

Mammalian Tissue Response to Low Dose Ionizing Radiation: The Role of Oxidative Metabolism and Intercellular Communication  

SciTech Connect

The objective of the project was to elucidate the mechanisms underlying the biological effects of low dose/low dose rate ionizing radiation in organs/tissues of irradiated mice that differ in their susceptibility to ionizing radiation, and in human cells grown under conditions that mimic the natural in vivo environment. The focus was on the effects of sparsely ionizing cesium-137 gamma rays and the role of oxidative metabolism and intercellular communication in these effects. Four Specific Aims were proposed. The integrated outcome of the experiments performed to investigate these aims has been significant towards developing a scientific basis to more accurately estimate human health risks from exposures to low doses ionizing radiation. By understanding the biochemical and molecular changes induced by low dose radiation, several novel markers associated with mitochondrial functions were identified, which has opened new avenues to investigate metabolic processes that may be affected by such exposure. In particular, a sensitive biomarker that is differentially modulated by low and high dose gamma rays was discovered.

Azzam, Edouard I

2013-01-16T23:59:59.000Z

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

15TH INTERNATIONAL SYMPOSIUM ON TOXICITY ASSESSMENT Alpha radiation exposure decreases apoptotic cells in zebrafish  

E-Print Network (OSTI)

15TH INTERNATIONAL SYMPOSIUM ON TOXICITY ASSESSMENT Alpha radiation exposure decreases apoptotic of an adaptive response by the ionizing radiation against sub- sequent exposures to Cd. Keywords Multiple embryos subjected to a priming exposure provided by one environmental stressor (low-dose alpha particles

Yu, K.N.

102

Analysis of the frequency response of a TeO{sub 2} slow shear wave acousto-optic cell exposed to radiation  

Science Conference Proceedings (OSTI)

Radiation testing of photonic components is not new, however component level testing to date has not completely addressed quantities which are important to system behavior. One characteristic that is of particular importance for optical processing systems is the frequency response. In this report, we present the analysis of data from an experiment designed to provide a preliminary understanding of the effects of radiation on the frequency response of acousto-optic devices. The goal of the analysis is to describe possible physical mechanisms responsible for the radiation effects and to discuss the effects on signal processing functionality. The experiment discussed in this report was designed by Sandia National Laboratories and performed by Sandia and Phillips Laboratory personnel at White Sands Missile Range (WSMR). In the experiment, a TeO{sub 2} slow shear wave acousto-optic cell was exposed to radiation from the WSMR linear accelerator. The TeO{sub 2} cell was placed in an experimental configuration which allowed swept frequency diffracted power measurements to be taken during radiation exposure and recovery. A series of exposures was performed. Each exposure consisted of between 1 to 800, 1{mu}sec radiation pulses (yielding exposures of 2.25 kRad(Si) to 913 kRad(Si)), followed by recovery time. At low total and cumulative doses, the bandshape of the frequency response (i.e. diffracted power vs. frequency) remained almost identical during and after radiation. At the higher exposures, however, the amplitude and width of the frequency response changed as the radiation continued, but returned to the original shape slowly after the radiation stopped and recovery proceeded. It is interesting to note that the location of the Bragg degeneracy does not change significantly with radiation. In this report, we discuss these effects from the perspective of anisotropic Bragg diffraction and momentum mismatch, and we discuss the effect on the signal processing functionality.

Erteza, I.A.

1995-04-01T23:59:59.000Z

103

Adapting the U.S. Domestic Radiological Emergency Response Process to an Overseas Incident: FRMAC Without the F  

Science Conference Proceedings (OSTI)

The earthquake and resulting tsunami in Japan led to a radiological release from the Fukushima Daiichi Nuclear Power Plan, which in turn resulted in the rapid activation and deployment by the U.S. Department of Energy National Nuclear Security Administration (DOE/NNSA) emergency response teams. These teams and those from other federal agencies are typically coordinated through the Federal Radiological Monitoring and Assessment Center (FRMAC) when responding to radiological incidents in the U.S. FRMAC is the body through which the collection, analysis, and assessment of environmental radiological data are coordinated and products released to decision makers. This article discusses DOE/NNSAs role in the U.S. response to the Fukushima accident as it implemented its components of FRMAC in a foreign country, coordinated its assets, integrated with its federal partners, and collaborated with the Government of Japan. The technical details of the various data collections and analyses are covered in other articles of this issue.

Blumenthal, Daniel J. [USDOE NA Office of Emergency Response; Bowman, David R. [USDOE NA Office of Emergency Response; Remick, Alan [USDOE NA Office of Emergency Response

2012-05-01T23:59:59.000Z

104

Statistical issues in radiation dose-response analysis of employees of the nuclear industry in Oak Ridge, Tennessee  

Science Conference Proceedings (OSTI)

Poisson regression methods are used to describe dose-response relations for cancer mortality for a subcohort of 28,347 white male radiation workers. Age specific baseline rates are described using both internal and external (US white male) rates. Regression analyses are based on an analytic data structure (ADS) that consists of a table of observed deaths, expected deaths, and person-years at risk for each combination of levels of seven risk factors. The factors are socioeconomic status, length of employment, birth cohort, age at risk, facility, internal exposure, and external exposure. Each observation in the ADS consists of the index value of each of the stratifying factors, the observed deaths, the expected deaths, the person-years, and the ten year lagged average cumulative dose. Regression diagnostics show that a linear exponential relative risk model is not appropriate for these data. Results are presented using a main effects model for factors other than external radiation, and an excess relative risk term for cumulative external radiation dose.

Frome, E.L. [Oak Ridge National Lab., TN (United States); Watkins, J.P. [Oak Ridge Inst. for Science and Education, TN (United States). Center for Epidemiologic Research

1997-11-01T23:59:59.000Z

105

Stratospheric Temperature and Radiative Forcing Response to 11-Year Solar Cycle Changes in Irradiance and Ozone  

Science Conference Proceedings (OSTI)

The 11-yr solar cycle temperature response to spectrally resolved solar irradiance changes and associated ozone changes is calculated using a fixed dynamical heating (FDH) model. Imposed ozone changes are from satellite observations, in contrast ...

L. J. Gray; S. T. Rumbold; K. P. Shine

2009-08-01T23:59:59.000Z

106

Non-linear DNA damage response to low-dose ionizing radiation...  

NLE Websites -- All DOE Office Websites (Extended Search)

the spatiotemporal response in ATM- or DNApkcs-deficient cells or as a function of chromatin territory, to extend the work done by the Karpen Lab using the Drosophila model...

107

Gravity Wave Radiation and Mean Responses to Local Body Forces in the Atmosphere  

Science Conference Proceedings (OSTI)

The authors determine the spectral linear solutions that arise in response to local 3D body forces and heatings in an idealized environment that turn on and off smoothly but not necessarily slowly over a finite interval in time. The solutions ...

Sharon L. Vadas; David C. Fritts

2001-08-01T23:59:59.000Z

108

Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans  

SciTech Connect

Microcephaly is a malformation associated with in utero exposed atomic bomb survivors and can be induced in mice by fetal exposure to ionizing radiation (IR). The pathogenesis of IR-induced microcephaly, however, has not been fully understood. Our analyses of high-coverage expression profiling (HiCEP) demonstrated that the abnormal spindle-like microcephaly associated gene (ASPM) was down-regulated in irradiated human diploid fibroblasts. ASPM was recently reported as the causative gene for MCPH-5, the most common type of congenital microcephaly in humans. Here, we show that the expression of the Aspm gene was significantly reduced by IR in various human and murine cells. Additionally, Aspm was found downregulated in the irradiated fetal mouse brain, particularly in the ventricular zones. A similar suppression was observed in the irradiated neurosphere cultures. This is the first report suggesting that the suppression of Aspm by IR could be the initial molecular target leading to the future microcephaly formation.

Fujimori, Akira [Cellular and Molecular Biology Team, National Institute of Radiological Sciences, Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan)], E-mail: fujimora@nirs.go.jp; Yaoi, Takeshi; Ogi, Hiroshi [Department of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine, Graduate School of Medical Sciences, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566 (Japan); Wang Bing [National Institute of Radiological Sciences, Heavy-Ion Radiology Research Group, Research Center for Charged Particle Therapy, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan); Suetomi, Katsutoshi; Sekine, Emiko; Yu Dong; Kato, Takamitsu [Cellular and Molecular Biology Team, National Institute of Radiological Sciences, Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan); Takahashi, Sentaro [National Institute of Radiological Sciences, Heavy-Ion Radiology Research Group, Research Center for Charged Particle Therapy, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan); Okayasu, Ryuichi [Cellular and Molecular Biology Team, National Institute of Radiological Sciences, Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan); Itoh, Kyoko; Fushiki, Shinji [Department of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine, Graduate School of Medical Sciences, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566 (Japan)

2008-05-09T23:59:59.000Z

109

Stability analyses of two-temperature radiative shocks formulation, eigenfunctions, luminosity response and boundary conditions  

E-Print Network (OSTI)

We present a general formulation for stability analyses of radiative shocks with multiple cooling processes, longitudinal and transverse perturbations, and unequal electron and ion temperatures. Using the accretion shocks of magnetic cataclysmic variables as an illustrative application, we investigate the shock instabilities by examining the eigenfunctions of the perturbed hydrodynamic variables. We also investigate the effects of varying the condition at the lower boundary of the post-shock flow from a zero-velocity fixed wall to several alternative type of boundaries involving the perturbed hydrodynamic variables, and the variations of the emission from the post-shock flow under different modes of oscillations. We found that the stability properties for flow with a stationary-wall lower boundary are not significantly affected by perturbing the lower boundary condition, and they are determined mainly by the energy-transport processes. Moreover, there is no obvious correlation between the amplitude or phase o...

Saxton, C J; Saxton, Curtis J.; Wu, Kinwah

2001-01-01T23:59:59.000Z

110

Low Dose Radiation Research Program: Checkpoint Responses and Repair of a  

NLE Websites -- All DOE Office Websites (Extended Search)

Checkpoint Responses and Repair of a Broken Chromosome in Budding Checkpoint Responses and Repair of a Broken Chromosome in Budding Yeast. Authors: André Walther, Mreshwar B. Vaze, Anna Malkova, Grzegorz Ira, Xuan Wang, Jung-Ae Kim, Neal Sugawara, James E. Haber Brandeis University, Waltham, Massachusetts We have studied how yeast cells respond to the creation of a single double-strand break (DSB) by using a site-specific endonuclease to create one (or more) DSBs. In collaboration with R. Schroff, M. Licheten and W. Bonner (NIH) we have shown that a single DSB rapidly becomes associated with histone H2AX-phosphorylation (y-H2AX) covering a distance of about 25 kb on either side of the DSB. The drop-off in phosphorylation is not attributable to specific boundary sequences. y-H2AX can be phosphorylated by either ATR (Mec1) or ATM (Tel1) protein kinases. A mutation that removes

111

Radiation Control (Virginia)  

Energy.gov (U.S. Department of Energy (DOE))

The Department of Health is responsible for regulating radiation and radioactive materials in the Commonwealth of Virginia. Although the Department's Radiation Control Program primarily focuses on...

112

Low Dose Radiation Research Program: Chaun-Yuan Li  

NLE Websites -- All DOE Office Websites (Extended Search)

Chaun-Yuan Li Chaun-Yuan Li Radiation Biology Research, Duke University Medical Center Funded Projects Molecular Characterization of the Role of SOD Genes in Mammalian Cellular Response to Low Dose Ionizing, abstract, description. Technical Abstracts 2006 Workshop: The Roles of Superoxide Dismutage (SOD) in Low Dose Radiation Induced Adaptive Response Yang, Z., Chuang, E., Batinic-Haberle, I., and Li, C.-Y. 2005 Workshop: Molecular Characterization of the Roles of SOD Genes in Mammalian Cellular Response to Low Dose Radiation Li, C.-Y., Guo, Z., Yang, Z., and Chuang, E. 2003 Workshop: Molecular Characterization of the Roles of SOD Genes in Mammalian Cellular Response to Low Dose Radiation Li, C.-Y. and Chuang, E. Publications Li, F., Sonveaux, P., Rabbani, Z.N., Liu, S., Yan, B., Huang, Q.,

113

Low Dose Radiation Research Program: William F. Morgan  

NLE Websites -- All DOE Office Websites (Extended Search)

William F. Morgan William F. Morgan Pacific Northwest National Laboratory PO Box 999 Richland, Washington About this Project Projects Using a Low LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation. Optimizing the Scientific, Regulatory, and Societal Impact of the DOE Low Dose Radiation Research Program A Mechanistic Study of the Radiation Quality Dependence of Bystander Effects in Human Cells. Genetic Factors Affecting Susceptibility to Low-Dose Radiation Mechanisms of Adaptive Responses and Genomic Instability Induced by Low Dose/ Low Dose Rate Radiation Technical Abstracts 2006 Workshop: Using a Low-LET Electron Microbeam to Investigate Non-Targeted Effects of Low Dose Radiation Sowa, M.B., Goetz, W., Baulch, J., and Morgan, W.F. Genetic Factors Affecting Susceptibility to Low-Dose Radiation

114

Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease  

SciTech Connect

Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy, environmental nuclear contamination, as well as earth orbit and space missions. Analyses of transcriptome profiles of murine brain tissue after whole-body radiation showed that low-dose exposures (10 cGy) induced genes not affected by high dose (2 Gy), and low-dose genes were associated with unique pathways and functions. The low-dose response had two major components: pathways that are consistently seen across tissues, and pathways that were brain tissue specific. Low-dose genes clustered into a saturated network (p < 10{sup -53}) containing mostly down-regulated genes involving ion channels, long-term potentiation and depression, vascular damage, etc. We identified 9 neural signaling pathways that showed a high degree of concordance in their transcriptional response in mouse brain tissue after low-dose radiation, in the aging human brain (unirradiated), and in brain tissue from patients with Alzheimer's disease. Mice exposed to high-dose radiation did not show these effects and associations. Our findings indicate that the molecular response of the mouse brain within a few hours after low-dose irradiation involves the down-regulation of neural pathways associated with cognitive dysfunctions that are also down regulated in normal human aging and Alzheimer's disease.

Lowe, Xiu R; Bhattacharya, Sanchita; Marchetti, Francesco; Wyrobek, Andrew J.

2008-06-06T23:59:59.000Z

115

Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease  

SciTech Connect

Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy, environmental nuclear contamination, as well as earth orbit and space missions. Analyses of transcriptome profiles of murine brain tissue after whole-body radiation showed that low-dose exposures (10 cGy) induced genes not affected by high dose (2 Gy), and low-dose genes were associated with unique pathways and functions. The low-dose response had two major components: pathways that are consistently seen across tissues, and pathways that were brain tissue specific. Low-dose genes clustered into a saturated network (p < 10{sup -53}) containing mostly down-regulated genes involving ion channels, long-term potentiation and depression, vascular damage, etc. We identified 9 neural signaling pathways that showed a high degree of concordance in their transcriptional response in mouse brain tissue after low-dose radiation, in the aging human brain (unirradiated), and in brain tissue from patients with Alzheimer's disease. Mice exposed to high-dose radiation did not show these effects and associations. Our findings indicate that the molecular response of the mouse brain within a few hours after low-dose irradiation involves the down-regulation of neural pathways associated with cognitive dysfunctions that are also down regulated in normal human aging and Alzheimer's disease.

Lowe, Xiu R; Bhattacharya, Sanchita; Marchetti, Francesco; Wyrobek, Andrew J.

2008-06-06T23:59:59.000Z

116

A tale of two houses: the human dimension of demand response enabling technology from a case study of an adaptive wireless thermostat.  

E-Print Network (OSTI)

and Ed Arens. 2008. Demand Response-Enabled ResidentialEfficiency and Demand Response Programs for 2005/2006.The Human Dimension of Demand Response Enabling Technology

Peffer, Therese; Arens, Edward A; Chen, Xue; Jang, Jaehwi; Auslander, David M.

2008-01-01T23:59:59.000Z

117

The Climate Adaptation Frontier  

Science Conference Proceedings (OSTI)

Climate adaptation has emerged as a mainstream risk management strategy for assisting in maintaining socio-ecological systems within the boundaries of a safe operating space. Yet, there are limits to the ability of systems to adapt. Here, we introduce the concept of an adaptation frontier , which is defined as a socio-ecological system s transitional adaptive operating space between safe and unsafe domains. A number of driving forces are responsible for determining the sustainability of systems on the frontier. These include path dependence, adaptation/development deficits, values conflicts and discounting of future loss and damage. The cumulative implications of these driving forces are highly uncertain. Nevertheless, the fact that a broad range of systems already persist at the edge of their frontiers suggests a high likelihood that some limits will eventually be exceeded. The resulting system transformation is likely to manifest as anticipatory modification of management objectives or loss and damage. These outcomes vary significantly with respect to their ethical implications. Successful navigation of the adaptation frontier will necessitate new paradigms of risk governance to elicit knowledge that encourages reflexive reevaluation of societal values that enable or constrain sustainability.

Preston, Benjamin L [ORNL

2013-01-01T23:59:59.000Z

118

COMMENTARY:Limits to adaptation  

SciTech Connect

An actor-centered, risk-based approach to defining limits to social adaptation provides a useful analytic framing for identifying and anticipating these limits and informing debates over society s responses to climate change.

Preston, Benjamin L [ORNL

2013-01-01T23:59:59.000Z

119

Radiosensitization of Human Cervical Cancer Cells by Inhibiting Ribonucleotide Reductase: Enhanced Radiation Response at Low-Dose Rates  

Science Conference Proceedings (OSTI)

Purpose: To test whether pharmacologic inhibition of ribonucleotide reductase (RNR) by 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC no. 663249) enhances radiation sensitivity during low-dose-rate ionizing radiation provided by a novel purpose-built iridium-192 cell irradiator. Methods and Materials: The cells were exposed to low-dose-rate radiation (11, 23, 37, 67 cGy/h) using a custom-fabricated cell irradiator or to high-dose-rate radiation (330 cGy/min) using a conventional cell irradiator. The radiation sensitivity of human cervical (CaSki, C33-a) cancer cells with or without RNR inhibition by 3-AP was evaluated using a clonogenic survival and an RNR activity assay. Alteration in the cell cycle distribution was monitored using flow cytometry. Results: Increasing radiation sensitivity of both CaSki and C33-a cells was observed with the incremental increase in radiation dose rates. 3-AP treatment led to enhanced radiation sensitivity in both cell lines, eliminating differences in cell cytotoxicity from the radiation dose rate. RNR blockade by 3-AP during low-dose-rate irradiation was associated with low RNR activity and extended G{sub 1}-phase cell cycle arrest. Conclusions: We conclude that RNR inhibition by 3-AP impedes DNA damage repair mechanisms that rely on deoxyribonucleotide production and thereby increases radiation sensitivity of human cervical cancers to low-dose-rate radiation.

Kunos, Charles A., E-mail: charles.kunos@UHhospitals.org [Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH (United States); Colussi, Valdir C. [Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH (United States); Pink, John [Department of General Medical Sciences, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH (United States); Radivoyevitch, Tomas [Department of Epidemiology and Biostatistics, Case Comprehensive Cancer Center, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH (United States); Oleinick, Nancy L. [Department of Radiation Oncology, University Hospitals Case Medical Center and Case Western Reserve School of Medicine, Cleveland, OH (United States)

2011-07-15T23:59:59.000Z

120

Adaptive sequential controller  

Science Conference Proceedings (OSTI)

An adaptive sequential controller for controlling a circuit breaker or other switching device to substantially eliminate transients on a distribution line caused by closing and opening the circuit breaker. The device adaptively compensates for changes in the response time of the circuit breaker due to aging and environmental effects. A potential transformer provides a reference signal corresponding to the zero crossing of the voltage waveform, and a phase shift comparator circuit compares the reference signal to the time at which any transient was produced when the circuit breaker closed, producing a signal indicative of the adaptive adjustment that should be made. Similarly, in controlling the opening of the circuit breaker, a current transformer provides a reference signal that is compared against the time at which any transient is detected when the circuit breaker last opened. An adaptive adjustment circuit produces a compensation time that is appropriately modified to account for changes in the circuit breaker response, including the effect of ambient conditions and aging. When next opened or closed, the circuit breaker is activated at an appropriately compensated time, so that it closes when the voltage crosses zero and opens when the current crosses zero, minimizing any transients on the distribution line. Phase angle can be used to control the opening of the circuit breaker relative to the reference signal provided by the potential transformer. 15 figs.

El-Sharkawi, M.A.; Xing, J.; Butler, N.G.; Rodriguez, A.

1994-11-01T23:59:59.000Z

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Adaptive sequential controller  

DOE Patents (OSTI)

An adaptive sequential controller (50/50') for controlling a circuit breaker (52) or other switching device to substantially eliminate transients on a distribution line caused by closing and opening the circuit breaker. The device adaptively compensates for changes in the response time of the circuit breaker due to aging and environmental effects. A potential transformer (70) provides a reference signal corresponding to the zero crossing of the voltage waveform, and a phase shift comparator circuit (96) compares the reference signal to the time at which any transient was produced when the circuit breaker closed, producing a signal indicative of the adaptive adjustment that should be made. Similarly, in controlling the opening of the circuit breaker, a current transformer (88) provides a reference signal that is compared against the time at which any transient is detected when the circuit breaker last opened. An adaptive adjustment circuit (102) produces a compensation time that is appropriately modified to account for changes in the circuit breaker response, including the effect of ambient conditions and aging. When next opened or closed, the circuit breaker is activated at an appropriately compensated time, so that it closes when the voltage crosses zero and opens when the current crosses zero, minimizing any transients on the distribution line. Phase angle can be used to control the opening of the circuit breaker relative to the reference signal provided by the potential transformer.

El-Sharkawi, Mohamed A. (Renton, WA); Xing, Jian (Seattle, WA); Butler, Nicholas G. (Newberg, OR); Rodriguez, Alonso (Pasadena, CA)

1994-01-01T23:59:59.000Z

122

On Hawking radiation of 2d Liouville black hole  

E-Print Network (OSTI)

We adapt the method of complex paths to the study of the radiation of Hawking of Liouville black holes.

Chabab, M; Sedra, M B

2011-01-01T23:59:59.000Z

123

A RadiativeConvective Equilibrium Perspective of Weakening of the Tropical Walker Circulation in Response to Global Warming  

Science Conference Proceedings (OSTI)

Both observational analysis and GCM simulations indicate that the tropical Walker circulation is becoming weaker and may continue to weaken as a consequence of climate change. Here, the authors use a conceptual radiativeconvective equilibrium (...

Xianglei Huang; Hui-Wen Chuang; Andrew Dessler; Xiuhong Chen; Kenneth Minschwaner; Yi Ming; V. Ramaswamy

2013-03-01T23:59:59.000Z

124

Response of the NCAR Community Climate Model to the Radiative Forcing by the Naturally Occurring Tropospheric Aerosol  

Science Conference Proceedings (OSTI)

We insert the effect of naturally occurring tropospheric aerosols on solar radiation into the NCAR Community Climate Model (CCM). The effect of the aerosol depends on concentration and type (continental, maritime), surface albedo, solar zenith ...

James A. Coakley Jr.; Robert D. Cess

1985-08-01T23:59:59.000Z

125

Molecular stress response in the CNS of mice after systemic exposure to interferon-alpha, ionizing radiation and ketamine  

E-Print Network (OSTI)

Lowe et al. , 2008 MOLECULAR STRESS RESPONSE IN THE CNS OFXRLowe@lbl.gov Keywords: molecular-response, troponin T1,1 expression may be an early molecular biomarker of stress

Lowe, Xiu R.

2009-01-01T23:59:59.000Z

126

Florida Radiation Protection Act (Florida)  

Energy.gov (U.S. Department of Energy (DOE))

The Department of Public Health is responsible for administering a statewide radiation protection program. The program is designed to permit development and utilization of sources of radiation for...

127

IMPRINTED GENES & TRANSPOSITIONS: EPIGENOMIC TARGETS FOR LOW DOSE RADIATION EFFECTS  

Science Conference Proceedings (OSTI)

The overall hypothesis of this grant application is that low dose ionizing radiation (LDIR) elicits adaptive responses in part by causing heritable DNA methylation changes in the epigenome. This novel postulate was tested by determining if the level of DNA methylation at the Agouti viable yellow (A{sup vy}) metastable locus is altered, in a dose-dependent manner, by low dose radiation exposure (radiation hormesis, bringing into question the assumption that every dose of radiation is harmful. Our findings not only have significant implications concerning the mechanism of hormesis, but they also emphasize the potential importance of this phenomenon in determining human risk at low radiation doses. Since the epigenetic regulation of genes varies markedly between species, the effect of LDIR on other epigenetically labile genes (e.g. imprinted genes) in animals and humans needs to be defined.

Randy Jirtle

2012-10-11T23:59:59.000Z

128

Radiation and Ozone  

Science Conference Proceedings (OSTI)

Radiation is the driving force for the general circulation of the atmosphere and controls the Earth's climate. Ozone is responsible for the warm stratosphere and protects life on Earth from harmful solar ultraviolet radiation. In July 1959, the ...

G. Ohring; R. D. Bojkov; H-J. Bolle; R. D. Hudson; H. Volkert

2009-11-01T23:59:59.000Z

129

Response of the mouse fetus to radiation from Na/sup 99m/TcO$sub 4$  

SciTech Connect

The element technetium has recently assumed ecological importance as a source of low-level radiation, with the use of /sup 99m/Tc in nuclear medicine and production of /sup 99m/Tc during generation of electricity by nuclear reaction. When technetium is introduced as pertechnetate into the blood stream of pregnant females, it is transported across the placental barrier to the fetus, where a portion appears to be incorporated into biomolecules. When combined as biomolecules, radionuclides that decay by electron capture or isomeric transition show a lethality greater than that predicted in cell cultures and radiation therapy. The decay of /sup 99m/Tc by isomeric transition, together with the other considerations, places a high priority on the investigation of its radiation effects due to clinical doses of up to 25 mCi. Female mice were given daily i.v. injections of 0, 5, 50, and 500 $mu$ Ci of /sup 99m/Tc as pertechnetate in isotonic saline throughout gestation, gestation and lactation, or lactation. At two months of age, the progeny were mated with randomly selected litter mates to produce a second generation; the process was repeated with their progeny for production of the third generation.Preliminary results reinforce the existing concern about use of /sup 99m/Tc-pertechnetate in pregnant or potentially pregnant subjects. (auth)

Lathrop, K.A.; Gloria, I.V.; Harper, P.V.

1975-01-01T23:59:59.000Z

130

Urban climate resilience : a global assessment of city adaptation plans  

E-Print Network (OSTI)

As policy makers accept climate change as an irrefutable threat, adaptation planning has emerged as a necessary action for countries, states, and municipalities. This thesis explores adaptive responses to climate change ...

Katich, Kristina Noel

2009-01-01T23:59:59.000Z

131

Low Dose Radiation Research Program: Jian Jian Li  

NLE Websites -- All DOE Office Websites (Extended Search)

Jian Jian Li Jian Jian Li School of Health Sciences, Purdue University Newly Funded Projects Regulation of NF-kB and Mn SOD in Low Dose Radiation-Induced Adaptive Responses in Mouse and Human Skin Cells, abstract, description. Technical Abstracts 2006 Workshops: NF-kB Mediated Signaling Network in Low Dose X-Ray Induced Adaptive Protection on Mouse and Human Skin Epithelial Cells Ahmed, K.M., Fan, M., Spitz, and Li, J.J. 2005 Workshops: Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Ionizing Radiation: Induction of NF-κB, MnSOD, 14-3-3ζ and Cyclin B1. Li, J.J., Ahmed, K.M., Fan, M., Dong, S., Spitz, D.R., and Yu, C.-R. 2003 Workshops: Gene Expression Profiles of Human Skin Keratinocytes Exposed to Acute and Chronic Ionizing Radiation Li, J.J., Ozeki, M., Wang, T., Tamae, D., Nelson, D., Wyrobek, A., and

132

Cross-layer wireless bit rate adaptation  

E-Print Network (OSTI)

This paper presents SoftRate, a wireless bit rate adaptation protocol that is responsive to rapidly varying channel conditions. Unlike previous work that uses either frame receptions or signal-to-noise ratio (SNR) estimates ...

Vutukuru, Mythili

2009-01-01T23:59:59.000Z

133

Cross-Layer Wireless Bit Rate Adaptation  

E-Print Network (OSTI)

This paper presents SoftRate, a wireless bit rate adaptation protocol that is responsive to rapidly varying channel conditions. Unlike previous work that uses either frame receptions or signal-to-noise ratio (SNR) estimates ...

Vutukuru, Mythili

134

Air Kerma Calibrations in Radiation Protection Level 137Cs ...  

Science Conference Proceedings (OSTI)

... Such instruments are used by radiation workers and users in the field of radiation protection, emergency response, homeland security, medicine ...

2013-03-13T23:59:59.000Z

135

PSA Response to Neoadjuvant Androgen Deprivation Therapy Is a Strong Independent Predictor of Survival in High-Risk Prostate Cancer in the Dose-Escalated Radiation Therapy Era  

SciTech Connect

Purpose: The aim of the study was to evaluate the prognostic value of prostate-specific antigen (PSA) response to neoadjuvant androgen deprivation therapy (ADT) prior to dose-escalated radiation therapy (RT) and long-term ADT in high-risk prostate cancer. Methods and Materials: We reviewed the charts of all patients diagnosed with high-risk prostate cancer and treated with a combination of long-term ADT (median, 24 months) and dose-escalated (median, 75.6 Gy) RT between 1990 and 2007. The associations among patient, tumor, and treatment characteristics with biochemical response to neoadjuvant ADT and their effects on failure-free survival (FFS), time to distant metastasis (TDM), prostate cancer-specific mortality (PCSM) and overall survival (OS) were examined. Results: A total of 196 patients met criteria for inclusion. Median follow-up time for patients alive at last contact was 7.0 years (range, 0.5-18.1 years). Multivariate analysis identified the pre-RT PSA concentration (<0.5 vs {>=}0.5 ng/mL) as a significant independent predictor of FFS (P=.021), TDM (P=.009), PCSM (P=.039), and OS (P=.037). On multivariate analysis, pretreatment PSA (iPSA) and African-American race were significantly associated with failure to achieve a pre-RT PSA of <0.5 ng/mL. Conclusions: For high-risk prostate cancer patients treated with long-term ADT and dose-escalated RT, a pre-RT PSA level {>=}0.5 ng/mL after neoadjuvant ADT predicts for worse survival measures. Both elevated iPSA and African-American race are associated with increased risk of having a pre-RT PSA level {>=}0.5 ng/mL. These patients should be considered for clinical trials that test newer, more potent androgen-depleting therapies such as abiraterone and MDV3100 in combination with radiation.

McGuire, Sean E., E-mail: semcguir@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas (United States); Lee, Andrew K. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Cerne, Jasmina Z. [Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas (United States)] [Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas (United States); Munsell, Mark F. [Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Levy, Lawrence B. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Kudchadker, Rajat J. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Choi, Seungtaek L.; Nguyen, Quynh N.; Hoffman, Karen E.; Pugh, Thomas J.; Frank, Steven J. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Corn, Paul G.; Logothetis, Christopher J. [Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Kuban, Deborah A. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

2013-01-01T23:59:59.000Z

136

Measuring Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Measurement Activity SI Units and Prefixes Conversions Safety Around Radiation Sources Types of Radiation Exposure Managing Radiation Emergencies Procedure Demonstration...

137

Low Dose Radiation Research Program: Wide Expression of LLIR and the  

NLE Websites -- All DOE Office Websites (Extended Search)

Wide Expression of LLIR and the Biological Consequences Wide Expression of LLIR and the Biological Consequences David J. Chen Lawrence Berkeley National Laboratory Why This Project It is known that changes in gene expression alter biological effects. It is necessary to identify the specific genes that demonstrate altered expression after exposure to low doses of ionizing radiation and to determine pathways involved in DNA damage recognition, signaling, and repair that are associated with radiation-induced adaptive and bystander effects. Project Goals Identification of genes whose transcription is regulated in response to low levels of ionizing radiation Identification of the genes and communication pathways that control these responses to low dose radiation Identification of the cellular and molecular targets that influence

138

Experimental Adaptive Bayesian Tomography  

E-Print Network (OSTI)

We report an experimental realization of an adaptive quantum state tomography protocol. Our method takes advantage of a Bayesian approach to statistical inference and is naturally tailored for adaptive strategies. For pure states we observe close to 1/N scaling of infidelity with overall number of registered events, while best non-adaptive protocols allow for $1/\\sqrt{N}$ scaling only. Experiments are performed for polarization qubits, but the approach is readily adapted to any dimension.

Konstantin Kravtsov; Stanislav Straupe; Igor Radchenko; Neil Houlsby; Sergey Kulik

2013-03-07T23:59:59.000Z

139

Inference of Causal Networks from Time-course Transcription Data in Response to a2 Gy Challenge Dose of Ionizing Radiation with or without a 10 cGy Priming Dose  

NLE Websites -- All DOE Office Websites (Extended Search)

Causal Networks from Time-course Transcription Data in Response to a Causal Networks from Time-course Transcription Data in Response to a 2 Gy Challenge Dose of Ionizing Radiation with or without a 10 cGy Priming Dose Kai Zhang, Ju Han, Torsten Groesser, Priscilla Cooper, and Bahram Parvin Lawrence Berkeley National Laboratory Goal: To elucidate temporal-dependent gene templates, causal networks, and underlying biological processes that can be inferred in response to a 10 cGy priming dose with or without a later higher challenged dose. Background and significance: Mechanistic inference of regulatory network can provide new insights into radiation systems biology. The main challenge continues to be high dimensionality of data, complex network architecture and limited knowledge of biological processes.

140

Low Dose Radiation Research Program: Computational Modeling of Biochemical  

NLE Websites -- All DOE Office Websites (Extended Search)

Computational Modeling of Biochemical Pathways Linking Ionizing Computational Modeling of Biochemical Pathways Linking Ionizing Radiation to Cell Cycle Arrest, Apoptosis, and Tumor Incidence Authors: Yuchao Maggie Zhao and Rory Conolly Institutions: Center for Computational Systems Biology CIIT Centers for Health Research Long-Range Goal: To develop an integrated, computational framework for the prediction of low-dose-response to ionizing radiation (IR) in people. Methodology: To provide a flexible framework to evaluate mechanisms of cellular adaptive responses after exposure to IR, three progressively more complicated descriptions of biochemical pathways linking DNA damage with cell-cycle checkpoint control and apoptosis were developed. These descriptions focus on p53-dependent checkpoint arrest and apoptosis, p73-dependent apoptosis, and Chk2-dependent checkpoint arrest,

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

RADIATION SAFETY MANUAL  

E-Print Network (OSTI)

RADIATION SAFETY is the responsibility of all faculty, staff and students who are directly or indirectly involved in the use of radioisotopes or radiation-producing machines. In July 1963, the State of Texas granted The University of Texas at Austin a broad radioactive materials license for research, development and instruction. While this means a minimum of controls by the state, it requires that The University establish and pursue an effective Radiation Safety Program. The Radiation Safety Committee is responsible for The University's radiation control program outlined in this manual. The use of radiation in a university, where a large number of people may be unaware of their exposure to radiation hazards, makes strict adherence to procedures established by federal and state authorities of paramount importance for the protection of The University and the safety of its faculty, staff and students. It is the responsibility of all faculty, staff and students involved in radiation work to familiarize themselves thoroughly with The University's radiation control program and to comply with its requirements and all applicable federal and state regulations. I hope you will always keep in mind that radiation safety depends on a continuous awareness of potential hazards and on the acceptance

unknown authors

2005-01-01T23:59:59.000Z

142

Low Dose Radiation Research Program: A Paracrine Signal Mediates The Cell  

NLE Websites -- All DOE Office Websites (Extended Search)

A Paracrine Signal Mediates The Cell Transformation Response To Low A Paracrine Signal Mediates The Cell Transformation Response To Low Dose Gamma Radiation in JB6 Cells. Authors: Thomas J. Weber,1 Robert W. Siegel,2 Lye M. Markillie,1 William B. Chrisler,1 Xingye C. Lei,3 and Nancy H. Colburn4 Institutions: 1Cell Biology and Biochemistry, Pacific Northwest National Laboratory, Richland, Washington. 2Protein Function, Pacific Northwest National Laboratory, Richland, Washington. 3Statistical and Mathematical Sciences, Pacific Northwest National Laboratory, Richland, Washington. 4Gene Regulation Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Frederick, Maryland. The carcinogenic response to radiation is complex and may involve adaptive cellular responses as well as a bystander effect mediated by paracrine or

143

Nanofoams Response to Radiation Damage  

Science Conference Proceedings (OSTI)

Conclusions of this presentation are: (1) np-Au foams were successfully synthesized by de-alloying process; (2) np-Au foams remain porous structure after Ne ion irradiation to 1 dpa; (3) SFTs were observed in irradiated np-Au foams with highest and intermediate flux, while no SFTs were observed with lowest flux; (4) SFTs were observed in irradiated np-Au foams at RT, whereas no SFTs were observed at LNT irradiation; (5) The diffusivity of vacancies in Au at RT is high enough so that the vacancies have enough time to agglomerate and thus collapse. As a result, SFTs were formed; (6) The high flux created much more damage/time, vacancies don't have enough time to diffuse or recombine. As a result, SFTs were formed.

Fu, Engang [Los Alamos National Laboratory; Serrano De Caro, Magdalena [Los Alamos National Laboratory; Wang, Yongqiang [Los Alamos National Laboratory; Nastasi, Michael [Nebraska Center for Energy Sciences Research, University of Nebraska-Lincoln, NE 68508; Zepeda-Ruiz, Luis [PLS, Lawrence Livermore National Laboratory, Livermore, CA 94551; Bringa, Eduardo M. [CONICET and Inst. Ciencias Basicas, Universidad Nacional de Cuyo, Mendoza, 5500 Argentina; Baldwin, Jon K. [Los Alamos National Laboratory; Caro, Jose A. [Los Alamos National Laboratory

2012-07-30T23:59:59.000Z

144

Effect of low-dose, low-LET γ-radiation and BaP injection on pulmonary  

NLE Websites -- All DOE Office Websites (Extended Search)

low-dose, low-LET γ-radiation and BaP injection on pulmonary low-dose, low-LET γ-radiation and BaP injection on pulmonary immunity in A/J mice K. Gott Lovelace Respiratory Research Institute Abstract Introduction: Low-dose, low-linear-energy-transfer (LET) radiation (LDR; < 100 mGy) activates the immune response (Nowosielska et al., 2006), presumably via epigenetic pathways (Scott et al., 2009) and has been implicated as suppressing both alpha-radiation-induced and smoking-related lung cancer (Scott et al. 2009). One of the hypothesized adaptive-response mechanisms by which LDR does so is by activating immune cell function in the lung, which would then increase their anti-cancer surveillance function (Liu, 2007; Bogdandi et al., 2010). One measure of activated immune cell function is their expression of markers on their cell surface that are

145

Radiation-Induced Bystander Effects and Relevance to Human Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation-Induced Bystander Effects and Relevance to Human Radiation Radiation-Induced Bystander Effects and Relevance to Human Radiation Exposures Review of phenomenon appears in Radiation Research Pamela Sykes and Benjamin Blyth One concern of radiobiologists is the effect radiation exposure might have on nearby unirradiated cells. For example, when only a small fraction of cells are directly hit by radiation energy, are the surrounding unirradiated cells also at an increased risk of cancer? The term "radiation-induced bystander effect" is used to describe radiation-induced biological changes that occur in unirradiated cells within an irradiated cell population. Radiation-induced bystander effects have become established in the vernacular and are considered as an authentic radiation response. However, there is still no consensus on a precise definition of the term, which

146

Radiation Emergency Medicine Fact Sheet  

NLE Websites -- All DOE Office Websites (Extended Search)

Improving Global Response Improving Global Response to Radiation Emergencies Improving Radiation Emergency Response Through Education and Specialized Expertise In the event of a radiological or nuclear incident, first responders as well as hospital and emergency management personnel must call on their knowledge and training to provide immediate and effective care for victims. Through practical, hands-on education programs, Oak Ridge Associated Universities (ORAU) is improving global response to radiation emergencies. In addition, dedicated 24/7 deployable teams of physicians, nurses, and health physicists from the Radiation Emergency Assistance Center/Training Site (REAC/TS), which is managed by ORAU for DOE/NNSA, provide expert medical management of radiological incidents

147

Low Dose Radiation Research Program: Douglas Boreham  

NLE Websites -- All DOE Office Websites (Extended Search)

Douglas Boreham McMaster University Past Funded Projects The Adaptive Response i p53 Cancer-prone Mice: Loss of Heterozygosity and Chromosome Instability Technical Abstracts 2003...

148

Adaptive Discrete Cosine Transform  

Science Conference Proceedings (OSTI)

The theory and performance of the adaptive discrete cosine transform filter is examined. The discrete cosine transform filter is a realization of an FIR filter as the cascade of an all-zero FIR filter with a bank of IIR digital resonators. Each bank ... Keywords: FIR filter, IIR digital resonators, LMS algorithm, adaptive discrete cosine transform filter, adaptive filters, all-zero FIR filter, filter coefficient, frequency, magnitude, phase, transfer function, update method

S. J. Bukowinski; L. Gerhardt; M. Fargues; G. Coutu

1995-10-01T23:59:59.000Z

149

About Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation What is radiation? Radiation is a form of energy that is a part of our everyday lives. All of us receive a "dose" of radiation each day. Most of the dose comes from...

150

Adaptive Video Retrieval  

E-Print Network (OSTI)

Hopfgartner,F. Villa,R. Urban,J. Jose,J.M. Proceedings of the First International Workshop on Adaptive Information Retrieval pp 28-29

Hopfgartner, F.

151

Estimation and Model Validation of Surface Solar Radiation and Cloud Radiative Forcing Using TOGA COARE Measurements  

Science Conference Proceedings (OSTI)

The Tropical Ocean and Global Atmosphere Coupled OceanAtmosphere Response Experiment (TOGA COARE) radiation measurements in the western Pacific warm pool are used to estimate surface solar radiation budgets and to validate radiation model ...

Ming-Dah Chou; Wenzhong Zhao

1997-04-01T23:59:59.000Z

152

Alpha Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Basics of Radiation Basics of Radiation Gamma Radiation and X-Rays Beta Radiation Alpha Radiation Irradiation Radioactive Contamination Definitions Detection Measurement Safety Around Radiation Sources Types of Radiation Exposure Managing Radiation Emergencies Basics of Radiation Characteristics of Alpha Radiation 1. Alpha radiation is not able to penetrate skin. 2. Alpha-emitting materials can be harmful to humans if the materials are inhaled, swallowed, or absorbed through open wounds. 3. A variety of instruments have been designed to measure alpha radiation. Special training in use of these instruments is essential for making accurate measurements. 4. A civil defense instrument (CD V-700) cannot detect the presence of radioactive materials that produce alpha radiation unless the radioactive materials also produce beta and/or gamma radiation.

153

Radiation: Radiation Control (Indiana)  

Energy.gov (U.S. Department of Energy (DOE))

It is the policy of the state to encourage the constructive uses of radiation and to control its harmful effects. This section contains regulations pertaining to the manufacture, use,...

154

Protection Against Ionizing Radiation in Extreme Radiation ...  

Science Conference Proceedings (OSTI)

Protection Against Ionizing Radiation in Extreme Radiation-resistant Microorganisms. ... Elucidated radiation protection by intracellular halides. ...

2013-05-01T23:59:59.000Z

155

Sequence comparison and environmental adaptation of a bacterial endonuclease  

Science Conference Proceedings (OSTI)

The periplasmic/extracellular bacterial enzyme endonuclease I was chosen as a model system to identify features that might be responsible for temperature- and salt adaptation. A statistical study of amino acid sequence properties belonging to endonuclease ... Keywords: Amino acid property, Cold adaptation, Endonuclease I, Halophilic enzymes, Sequence analysis

Bjrn Altermark; Steinar Thorvaldsen; Elin Moe; Arne O. Smals; Nils P. Willassen

2007-06-01T23:59:59.000Z

156

Unifying design and runtime software adaptation using aspect models  

Science Conference Proceedings (OSTI)

Software systems are seen more and more as evolutive systems. At the design phase, software is constantly in adaptation by the building process itself, and at runtime, it can be adapted in response to changing conditions in the executing environment ... Keywords: Aspect oriented modeling, Software product lines

Carlos Parra; Xavier Blanc; Anthony Cleve; Laurence Duchien

2011-12-01T23:59:59.000Z

157

Low Dose Ionizing Radiation Modulates Immune Function New Project Overview  

NLE Websites -- All DOE Office Websites (Extended Search)

Modulates Immune Function New Project Overview Modulates Immune Function New Project Overview Gregory Nelson Loma Linda University Abstract The immune system provides the first line of defense for exposures to environmental hazards. Protective immunity mechanisms using innate or adaptive responses are employed to mitigate acute challenges or amplify the readiness of the system to respond to future challenges. Some stimuli lead to amplified inflammatory reactions such as delayed hypersensitivity which is required for immunity to parasites and can also lead to adverse consequences such as contact dermatitis. Radiation exposure has the potential to aggravate hypersensitivity reactions as well as to suppress protective immunity. Ionizing radiation at high doses has long been recognized as highly effective in destroying cells of the immune system,

158

Effect of low-dose, low-LET γ-radiation and BaP injection on pulmonary immunity in A/J mice  

NLE Websites -- All DOE Office Websites (Extended Search)

low-dose, low-LET γ-radiation and BaP injection on pulmonary immunity in A/J mice low-dose, low-LET γ-radiation and BaP injection on pulmonary immunity in A/J mice K. Gott, V. Gonzales, M. Makvandi, N. Kikendall, A. Monier, E. Maloy, C. Rietz, B. Scott and J. Wilder. Lovelace Respiratory Research Institute, Albuquerque, NM Introduction: Low-dose, low-linear-energy-transfer (LET) radiation (LDR; < 100 mGy) activates the immune response (Nowosielska et al., 2006), presumably via epigenetic pathways (Scott et al., 2009) and has been implicated as suppressing both alpha-radiation-induced and smoking-related lung cancer (Scott et al. 2009). One of the hypothesized adaptive-response mechanisms by which LDR does so is by activating immune cell function in the lung, which would then increase their anti-cancer surveillance

159

Leak test adapter for containers  

DOE Patents (OSTI)

An adapter is provided for facilitating the charging of containers and leak testing penetration areas. The adapter comprises an adapter body and stem which are secured to the container`s penetration areas. The container is then pressurized with a tracer gas. Manipulating the adapter stem installs a penetration plug allowing the adapter to be removed and the penetration to be leak tested with a mass spectrometer. Additionally, a method is provided for using the adapter. The present invention relates generally to leak test adapters, and more particularly to leak test adapters used with containers such as radioactive material shipping containers.

Hallett, B.H.; Hartley, M.S.

1995-12-31T23:59:59.000Z

160

Cellular and molecular level responses after radiofrequency radiation exposure, alone or in combination with x-rays or chemicals. Final report, 1 April 1991-30 September 1994  

SciTech Connect

This project was initiated to explore the potential bioeffects of microwave radiation, alone or in combination with ionizing radiation and chemicals. Over the time period of the project, an automated thermal control system, to be used for maintaining the temperature in tissue culture medium during microwave exposures, was designed, constructed, and software was created. While this was underway during the project period, numerous positive control biological experiments were performed on two different cell types, the Epstein Barr Virus transformed 244B human lymphoblastoid cell, and the freshly isolated peripheral human lymphocyte. The 244B cells were used to address the question of whether a physical agent, ionizing radiation, at low doses where cells would predominantly remain viable, would induce the DNA binding protein NF-kB, and/or four immediate early genes (IEG) (protooncogenes).

Meltz, M.L.; Natarajan, M.; Prasad, A.V.

1995-02-21T23:59:59.000Z

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Beta Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Beta Radiation 1. Beta radiation may travel meters in air and is moderately penetrating. 2. Beta radiation can penetrate human skin to the "germinal layer," where new skin cells...

162

RADIATION MONITORING  

E-Print Network (OSTI)

of Monitoring for Radiation Protection of Workers" in ICRPNo. 9, in "Advances in Radiation Protection and Dosimetry inDosimetry f o r Stray Radiation Monitoring on the CERN S i t

Thomas, R.H.

2010-01-01T23:59:59.000Z

163

Optical Military Systems Adaptive  

NLE Websites -- All DOE Office Websites (Extended Search)

turbulence in ground-based telescopes or to improve the spatial mode and power of lasers. More recently, Sandia has led the innovation of using adaptive elements, such as...

164

DOI: 10.2203/dose-response.10-003.Cuttler COMMENTARY ON USING LNT FOR RADIATION PROTECTION AND RISK ASSESSMENT  

E-Print Network (OSTI)

? An article by Jerome Puskin attempts to justify the continued use of the linear nothreshold (LNT) assumption in radiation protection and risk assessment. In view of the substantial and increasing amount of data that contradicts this assumption; it is difficult to understand the reason for endorsing this unscientific behavior, which severely constrains nuclear energy projects and the use of CT scans in medicine. Many Japanese studies over the past 25 years have shown that low doses and low dose rates of radiation improve health in living organisms including humans. Recent studies on fruit flies have demonstrated that the original basis for the LNT notion is invalid. The Puskin article omits any mention of important reports from UNSCEAR, the NCRP and the French Academies of Science and Medicine, while citing an assessment of the Canadian breast cancer study that manipulated the data to obscure evidence of reduced breast cancer mortality following a low total dose. This commentary provides dose limits that are based on real human data, for both single and chronic radiation exposures. Jerome Puskins perspective on the use of the linear no-threshold (LNT) assumption for radiation protection and risk assessment (Puskin

unknown authors

2010-01-01T23:59:59.000Z

165

Prevention of Low Dose Radiation-Induced Genomic Instability with Clinically Relevant Non-Protein Thiols and Vitamin E.  

NLE Websites -- All DOE Office Websites (Extended Search)

Prevention of Low Dose Radiation-Induced Genomic Instability with Clinically Relevant Prevention of Low Dose Radiation-Induced Genomic Instability with Clinically Relevant Non-Protein Thiols and Vitamin E. J.S. Murley 1 , Y. Kataoka 1 , W.F. Morgan 2 , and D.J. Grdina 1 . The University of Chicago, Chicago, IL 1 , The University of Maryland Medical School, Baltimore, MD 2 Induced or delayed radioprotection is a novel phenomenon that shares many similarities with the low dose radiation-induced radiobiological phenomenon referred to as the adaptive response. Induced or delayed radioprotection is defined as an enhancement in the radiation resistance of cells at long times following their exposure to non-protein thiols (NPT) such as WR1065, the free thiol form of amifostine. This effect is the result of the induction of a cascade of intracellular

166

Ionizing radiation detector  

DOE Patents (OSTI)

An ionizing radiation detector is provided which is based on the principal of analog electronic integration of radiation sensor currents in the sub-pico to nano ampere range between fixed voltage switching thresholds with automatic voltage reversal each time the appropriate threshold is reached. The thresholds are provided by a first NAND gate Schmitt trigger which is coupled with a second NAND gate Schmitt trigger operating in an alternate switching state from the first gate to turn either a visible or audible indicating device on and off in response to the gate switching rate which is indicative of the level of radiation being sensed. The detector can be configured as a small, personal radiation dosimeter which is simple to operate and responsive over a dynamic range of at least 0.01 to 1000 R/hr.

Thacker, L.H.

1989-06-08T23:59:59.000Z

167

Ionizing radiation detector  

DOE Patents (OSTI)

An ionizing radiation detector is provided which is based on the principle of analog electronic integration of radiation sensor currents in the sub-pico to nano ampere range between fixed voltage switching thresholds with automatic voltage reversal each time the appropriate threshold is reached. The thresholds are provided by a first NAND gate Schmitt trigger which is coupled with a second NAND gate Schmitt trigger operating in an alternate switching state from the first gate to turn either a visible or audible indicating device on and off in response to the gate switching rate which is indicative of the level of radiation being sensed. The detector can be configured as a small, personal radiation dosimeter which is simple to operate and responsive over a dynamic range of at least 0.01 to 1000 R/hr.

Thacker, Louis H. (Knoxville, TN)

1990-01-01T23:59:59.000Z

168

ORISE: REAC/TS Emergency Response Services  

NLE Websites -- All DOE Office Websites (Extended Search)

Emergency Response Services Emergency Response Services The Radiation Emergency Assistance CenterTraining Site (REACTS) at the Oak Ridge Institute for Science and Education...

169

Virtual Gamma Ray Radiation Sources through Neutron Radiative Capture  

SciTech Connect

The countrate response of a gamma spectrometry system from a neutron radiation source behind a plane of moderating material doped with a nuclide of a large radiative neutron capture cross-section exhibits a countrate response analogous to a gamma radiation source at the same position from the detector. Using a planar, surface area of the neutron moderating material exposed to the neutron radiation produces a larger area under the prompt gamma ray peak in the detector than a smaller area of dimensions relative to the active volume of the gamma detection system.

Scott Wilde, Raymond Keegan

2008-07-01T23:59:59.000Z

170

Optical Radiation  

Science Conference Proceedings (OSTI)

*. Bookmark and Share. Optical Radiation Measurements. Fees for services are located directly below the technical contacts ...

2013-04-09T23:59:59.000Z

171

Ionizing Radiation  

Science Conference Proceedings (OSTI)

*. Bookmark and Share. Ionizing Radiation Measurements. Fees for services are located directly below the technical contacts ...

2013-04-09T23:59:59.000Z

172

Investigation of non-targeted effects of low dose ionizing radiation on the mammary gland  

NLE Websites -- All DOE Office Websites (Extended Search)

non-targeted effects of low dose ionizing radiation on the mammary gland non-targeted effects of low dose ionizing radiation on the mammary gland utilizing three-dimensional culture models of mammary cells derived from mouse strains that differ in susceptibility to tumorigenesis Joni D. Mott, Antoine M. Snijders, Alvin Lo, Dinah Levy-Groesser, Bahram Parvin, Andrew J. Wyrobek, Jian-Hua Mao, and Mina J. Bissell Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley CA 94720 Goal: Within the Lawrence Berkeley National Laboratory's SFA, Project 2, our studies focus on utilizing three dimensional (3D) cell culture models as surrogates for in vivo studies to determine how low doses of ionizing radiation influence mammary gland tissue architecture and how this may relate both to tumor progression and/or adaptive response.

173

Improving fairness, efficiency, and stability in HTTP-based adaptive video streaming with FESTIVE  

Science Conference Proceedings (OSTI)

Many commercial video players rely on bitrate adaptation logic to adapt the bitrate in response to changing network conditions. Past measurement studies have identified issues with today's commercial players with respect to three key metrics---efficiency, ... Keywords: DASH, HTTP, adaptation, video

Junchen Jiang; Vyas Sekar; Hui Zhang

2012-12-01T23:59:59.000Z

174

Radiative Forcing of Climate Change  

SciTech Connect

Chapter 6 of the IPCC Third Assessment Report Climate Change 2001: The Scientific Basis. Sections include: Executive Summary 6.1 Radiative Forcing 6.2 Forcing-Response Relationship 6.3 Well-Mixed Greenhouse Gases 6.4 Stratospheric Ozone 6.5 Radiative Forcing By Tropospheric Ozone 6.6 Indirect Forcings due to Chemistry 6.7 The Direct Radiative Forcing of Tropospheric Aerosols 6.8 The Indirect Radiative Forcing of Tropospheric Aerosols 6.9 Stratospheric Aerosols 6.10 Land-use Change (Surface Albedo Effect) 6.11 Solar Forcing of Climate 6.12 Global Warming Potentials hydrocarbons 6.13 Global Mean Radiative Forcings 6.14 The Geographical Distribution of the Radiative Forcings 6.15 Time Evolution of Radiative Forcings Appendix 6.1 Elements of Radiative Forcing Concept References.

Ramaswamy, V.; Boucher, Olivier; Haigh, J.; Hauglustaine, D.; Haywood, J.; Myhre, G.; Nakajima, Takahito; Shi, Guangyu; Solomon, S.; Betts, Robert E.; Charlson, R.; Chuang, C. C.; Daniel, J. S.; Del Genio, Anthony D.; Feichter, J.; Fuglestvedt, J.; Forster, P. M.; Ghan, Steven J.; Jones, A.; Kiehl, J. T.; Koch, D.; Land, C.; Lean, J.; Lohmann, Ulrike; Minschwaner, K.; Penner, Joyce E.; Roberts, D. L.; Rodhe, H.; Roelofs, G.-J.; Rotstayn, Leon D.; Schneider, T. L.; Schumann, U.; Schwartz, Stephen E.; Schwartzkopf, M. D.; Shine, K. P.; Smith, Steven J.; Stevenson, D. S.; Stordal, F.; Tegen, I.; van Dorland, R.; Zhang, Y.; Srinivasan, J.; Joos, Fortunat

2001-10-01T23:59:59.000Z

175

Verification of Adaptive Systems  

SciTech Connect

Adaptive systems are critical for future space and other unmanned and intelligent systems. Verification of these systems is also critical for their use in systems with potential harm to human life or with large financial investments. Due to their nondeterministic nature and extremely large state space, current methods for verification of software systems are not adequate to provide a high level of assurance for them. The combination of stabilization science, high performance computing simulations, compositional verification and traditional verification techniques, plus operational monitors, provides a complete approach to verification and deployment of adaptive systems that has not been used before. This paper gives an overview of this approach.

Pullum, Laura L [ORNL; Cui, Xiaohui [New York Institute of Technology (NYIT); Vassev, Emil [Lero The Irish Software Engineering Research Centre; Hinchey, Mike [Lero The Irish Software Engineering Research Centre; Rouff, Christopher [Lockheed Martin Corporation; Buskens, Richard [Lockheed Martin Corporation

2012-01-01T23:59:59.000Z

176

Responses of Cell Renewal Systems to Long-term Low-Level Radiation Exposure: A Feasibility Study Applying Advanced Molecular Biology Techniques on Available Histological and Cytological Material of Exposed Animals and Men  

SciTech Connect

First results of this feasibility study showed that evaluation of the stored material of the chronically irradiated dogs with modern molecular biological techniques proved to be successful and extremely promising. Therefore an in deep analysis of at least part of the huge amount of remaining material is of outmost interest. The methods applied in this feasibility study were pathological evaluation with different staining methods, protein analysis by means of immunohistochemistry, strand break analysis with the TdT-assay, DNA- and RNA-analysis as well as genomic examination by gene array. Overall more than 50% of the investigated material could be used. In particular the results of an increased stimulation of the immune system within the dogs of the 3mSv group as both compared to the control and higher dose groups gives implications for the in depth study of the cellular events occurring in context with low dose radiation. Based on the findings of this study a further evaluation and statistically analysis of more material can help to identify promising biomarkers for low dose radiation. A systematic evaluation of a correlation of dose rates and strand breaks within the dog tissue might moreover help to explain mechanisms of tolerance to IR. One central problem is that most sequences for dog specific primers are not known yet. The discovery of the dog genome is still under progress. In this study the isolation of RNA within the dog tissue was successful. But up to now there are no gene arrays or gene chips commercially available, tested and adapted for canine tissue. The uncritical use of untested genomic test systems for canine tissue seems to be ineffective at the moment, time consuming and ineffective. Next steps in the investigation of genomic changes after IR within the stored dog tissue should be limited to quantitative RT-PCR of tested primer sequences for the dog. A collaboration with institutions working in the field of the discovery of the dog genome could have synergistic effects.

Fliedner Theodor M.; Feinendegen Ludwig E.; Meineke Viktor; Fritz Thomas E.

2005-02-28T23:59:59.000Z

177

AREA RADIATION MONITOR  

DOE Patents (OSTI)

S>An improved area radiation dose monitor is designed which is adapted to compensate continuously for background radiation below a threshold dose rate and to give warning when the dose integral of the dose rate of an above-threshold radiation excursion exceeds a selected value. This is accomplished by providing means for continuously charging an ionization chamber. The chamber provides a first current proportional to the incident radiation dose rate. Means are provided for generating a second current including means for nulling out the first current with the second current at all values of the first current corresponding to dose rates below a selected threshold dose rate value. The second current has a maximum value corresponding to that of the first current at the threshold dose rate. The excess of the first current over the second current, which occurs above the threshold, is integrated and an alarm is given at a selected integrated value of the excess corresponding to a selected radiation dose. (AEC)

Manning, F.W.; Groothuis, S.E.; Lykins, J.H.; Papke, D.M.

1962-06-12T23:59:59.000Z

178

About Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation Radiation What is radiation? Radiation is a form of energy that is a part of our everyday lives. All of us receive a "dose" of radiation each day. Most of the dose comes from naturally occurring radioactive materials such as uranium, thorium, radon, and certain forms of potassium and carbon. The air we breathe contains radon, the food we eat contains uranium and thorium from the soil, and our bodies contain radioactive forms of potassium and carbon. Cosmic radiation from the sun also contributes to our natural radiation dose. We also receive radiation doses from man-made sources such as X-rays, nuclear medical procedures, power plants, smoke detectors and older television sets. Some people, such as nuclear plant operators, flight crews, and nuclear medicine staff may also receive an occupational radiation dose.

179

Plants remember drought, adapt  

Science Conference Proceedings (OSTI)

Research carried out at the University of Nebraska-Lincoln (UNL; USA) shows that plants subjected to a previous period of drought learn to deal with the stress owing to their memories of the experience. Plants remember drought, adapt Inform Magazine

180

Radiation Physics Portal  

Science Conference Proceedings (OSTI)

NIST Home > Radiation Physics Portal. Radiation Physics Portal. ... more. >> see all Radiation Physics programs and projects ... ...

2013-08-08T23:59:59.000Z

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Environment/Health/Safety (EHS): Radiation Protection Group: Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Who To Call Who To Call Rad Training Dosimetry Telemetry Laser Safety Radiation Safety Committee Pub-3000 Ch. 21 Forms RPG Procedures RPG Internal Radiation Safety Committee Charter Purpose The Berkeley Lab Radiation Safety Committee (RSC) is appointed by, and reports to, the Laboratory Director and is responsible for advising LBNL Management on all matters related to occupational and environmental radiation safety. The Radiation Safety Committee reviews and recommends approval of radiation safety policies and guides the Environment, Health and Safety Division and radiation user divisions in carrying out these programs. The scope of its actions will generally be in issues of broad institutional concern and impact, or areas of potential high consequence either in terms of safety or institutional needs.

182

Radiation Cataract  

NLE Websites -- All DOE Office Websites (Extended Search)

radiation including patients undergoing diagnostic CT scans or radiotherapy, atomic bomb survivors, residents of radioactively contaminated buildings, victims of the...

183

Adaptive Constraints for Feature Tracking  

Science Conference Proceedings (OSTI)

In this paper extensions to an existing tracking algorithm are described. These extensions implement adaptive tracking constraints in the form of regional upper-bound displacements and an adaptive track smoothness constraint. Together, these ...

K. I. Hodges

1999-06-01T23:59:59.000Z

184

Low Dose Radiation Research Program: Katherine Vallis  

NLE Websites -- All DOE Office Websites (Extended Search)

Margaret Hospital Newly Funded Project The Characterization of Genetic Responses to Low Dose Radiation Using a Genome-Wide Insertional Mutagensis Approach Technical Abstracts 2005...

185

Low Dose Radiation Research Program: Multidimensional Analysis...  

NLE Websites -- All DOE Office Websites (Extended Search)

Multidimensional Analysis of Human Epithelial Cell Response to Low Dose Radiation Mary Helen Barcellos-Hoff Lawrence Berkeley National Laboratory Berkeley, CA. (Jointly funded by...

186

RADIATION MONITOR CONTAINING TWO CONCENTRIC IONIZATION CHAMBERS AND MEANS FOR INSULATING THE SEPARATE CHAMBERS  

DOE Patents (OSTI)

This invention relates to a portable radiation monitor containing two concentric ionization chambers which permit the use of standard charging and reading devices. It is particularly adapted as a personnel x-ray dosimeter and to this end comprises a small thin walled, cylindrical conductor forming an inner energy dependent chamber, a small thin walled, cylindrical conductor forming an outer energy independent chamber, and polymeric insulation means which insulates said chambers from each other and holds the chambers together with exposed connections in a simple, trouble-free, and compact assembly substantially without variation in directional response. (AEC)

Braestrup, C.B.; Mooney, R.T.

1964-01-21T23:59:59.000Z

187

Radiation Information  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation Information << Timeline >> Content on this page requires a newer version of Adobe Flash Player. Get Adobe Flash player July 31, 1942 The Army Corp of Engineers leases...

188

High-let radiation carcinogenesis  

SciTech Connect

Recent results for neutron radiation-induced tumors are presented to illustrate the complexities of the dose-response curves for high-LET radiation. It is suggested that in order to derive an appropriate model for dose-response curves for the induction of tumors by high-LET radiation it is necessary to take into account dose distribution, cell killing and the susceptibility of the tissue under study. Preliminary results for the induction of Harderian gland tumors in mice exposed to various heavy ion beams are presented. The results suggest that the effectiveness of the heavy ion beams increases with increasing LET. The slopes of the dose-response curves for the different high-LET radiations decrease between 20 and 40 rads and therefore comparisons of the relative effectiveness should be made from data obtained at doses below about 20 to 30 rads.

Fry, R.J.M.; Powers-Risius, P.; Alpen, E.L.; Ainsworth, E.J.; Ullrich, R.L.

1982-01-01T23:59:59.000Z

189

Radiation and viral DNA  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation and viral DNA Radiation and viral DNA Name: Loretta L Lamb Age: N/A Location: N/A Country: N/A Date: N/A Question: Can viral DNA be changed through exposure to radiation? If so, what type of radiation will do this? Can these irradiated viruses cause changes in the genome of any human cells they may infect? Can these (or any) viruses actually cause cancer, or do they merely act as triggering devices for cancer? Replies: In theory, any nucleic acid (viral or otherwise) can be changed by exposure to many kinds of radiation. Depending on the type of virus, these may then change the human cells that they infect. Although there are many different things that are being implicated in causing cancers, it looks like a fairly common model involves the sequential "knockout" of several human genes. Viruses may be one cause of such gene changes, radiation and other environmental causes may also contribute. Some of these changes may be inherited through families, so it becomes more likely that the environmental factors may happen to "hit" the right places in cells to cause cancers in these families. If you ask something more specific, perhaps I can focus my response a bit more

190

Adaptive control for energy conservation  

DOE Green Energy (OSTI)

The objective of this project is to investigate the use of adaptive control concepts in buildings with solar-assisted heating, ventilating, and air-conditioning (HVAC) systems to maintain occupant comfort conditions while minimizing auxiliary energy use. Accomplishing this objective requires an energy management system capable of making sound tradeoffs. Optimal control theory is used along with a system identification technique to provide an adaptable stratgy. The resulting overall approach is known as adaptive optimal control (AOC).

Farris, D.R.

1980-03-01T23:59:59.000Z

191

Adaptive capacity and its assessment  

SciTech Connect

This paper reviews the concept of adaptive capacity and various approaches to assessing it, particularly with respect to climate variability and change. I find that adaptive capacity is a relatively under-researched topic within the sustainability science and global change communities, particularly since it is uniquely positioned to improve linkages between vulnerability and resilience research. I identify opportunities for advancing the measurement and characterization of adaptive capacity by combining insights from both vulnerability and resilience frameworks, and I suggest several assessment approaches for possible future development that draw from both frameworks and focus on analyzing the governance, institutions, and management that have helped foster adaptive capacity in light of recent climatic events.

Engle, Nathan L.

2011-04-20T23:59:59.000Z

192

Definition of Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Gamma Radiation and X-Rays Beta Radiation Alpha Radiation Irradiation Radioactive Contamination Definitions Detection Measurement Safety Around Radiation Sources Types of...

193

How to Detect Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

How to Detect Radiation How to Survey Measurement Safety Around Radiation Sources Types of Radiation Exposure Managing Radiation Emergencies Procedure Demonstration Detection How...

194

Emittance Adapter for a Diffraction Limited Synchrotron Radiation Source  

Science Conference Proceedings (OSTI)

We investigate the possibility of reaching very small horizontal and vertical emittances inside an undulator in a storage ring, by means of a local exchange of the apparent horizontal and vertical emittances, performed with a combination of skew quadrupoles and one solenoid in a dedicated insertion line in the storage ring. The insertion leaves the ring parameters and its optical properties unaffected. This scheme could greatly relax the emittance requirements for a diffraction limited synchrotron light source. The lattice derivation and design is described.

Chao, Alexander Wu; /SLAC; Raimondi, Pantaleo; /Frascati

2012-03-01T23:59:59.000Z

195

Effects of Radiation on Adaptive Immunity: Contact Hypersensitivity...  

NLE Websites -- All DOE Office Websites (Extended Search)

of the nonhomologous end joining mechanism of DNA repair. Clinically, whole body irradiation is used in treatment of some lymphomas and as an immunosuppressive agent for bone...

196

Profile-Based Adaption . . .  

E-Print Network (OSTI)

Cache decay is a set of leakage-reduction mechanisms that put cache lines that have not been accessed for a specific duration into a low-leakage standby mode. This duration is called the decay interval, and its optimal value varies across applications. This paper provides an extended discussion of the results previously presented in our journal paper [13]. It describes an adaptation technique that analytically finds the optimal decay interval through profiling, and shows that the most important variables required for finding the optimal decay interval can be estimated with a reasonable degree of accuracy using profiling. This work explicitly trades off the leakage power saved in putting both the live and dead lines into standby mode, against its performance and energy costs. It achieves energy savings close to what can be obtained with an omniscient choice of per-benchmark optimal decay interval.

Karthik Sankaranarayanan; Kevin Skadron

2004-01-01T23:59:59.000Z

197

Adaptive neuro fuzzy controller for adaptive compliant robotic gripper  

Science Conference Proceedings (OSTI)

The requirement for new flexible adaptive grippers is the ability to detect and recognize objects in their environments. It is known that robotic manipulators are highly nonlinear systems, and an accurate mathematical model is difficult to obtain, thus ... Keywords: ANFIS controller, Adaptive compliant gripper, Embedded sensors, Fuzzy logic, Object recognizing

Dalibor Petkovi?; Mirna Issa; Nenad D. Pavlovi?; Lena Zentner; Arko OjbaI?

2012-12-01T23:59:59.000Z

198

Radiation dosimeter  

DOE Patents (OSTI)

A radiation detector readout circuit is provided which produces a radiation dose-rate readout from a detector even though the detector output may be highly energy dependent. A linear charge amplifier including an output charge pump circuit amplifies the charge signal pulses from the detector and pumps the charge into a charge storage capacitor. The discharge rate of the capacitor through a resistor is controlled to provide a time-dependent voltage which when integrated provides an output proportional to the dose-rate of radiation detected by the detector. This output may be converted to digital form for readout on a digital display.

Fox, Richard J. (Oak Ridge, TN)

1983-01-01T23:59:59.000Z

199

Radiation dosimeter  

DOE Patents (OSTI)

A radiation detector readout circuit is provided which produces a radiation dose-rate readout from a detector even through the detector output may be highly energy dependent. A linear charge amplifier including an output charge pump circuit amplifies the charge signal pulses from the detector and pumps the charge into a charge storage capacitor. The discharge rate of the capacitor through a resistor is controlled to provide a time-dependent voltage which when integrated provides an output proportional to the dose-rate of radiation detected by the detector. This output may be converted to digital form for readout on a digital display.

Fox, R.J.

1981-09-01T23:59:59.000Z

200

Low Dose Radiation Research Program: Low Dose Radiation Effects in  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation Effects in Differentiating Human Lens Cells Radiation Effects in Differentiating Human Lens Cells E.A. Blakely1, M.P. McNamara1, P.Y. Chang1, K.A. Bjornstad1, D. Sudar1, and A.C. Thompson2 1Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California; 2Advanced Light Source Division, Lawrence Berkeley National Laboratory, Berkeley, California. Introduction The human lens is one of the most radiosensitive organs of the body. Cataract, the opacification of the lens, is a late-appearing response to radiation damage. There are few data available on the late radiation effects of exposure in space flight to charged particle beams, the most prevalent of which are protons. Basic research in this area is needed to integrate the responses of both critical and other representative tissues

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Radiation Hydrodynamics  

DOE Green Energy (OSTI)

The discipline of radiation hydrodynamics is the branch of hydrodynamics in which the moving fluid absorbs and emits electromagnetic radiation, and in so doing modifies its dynamical behavior. That is, the net gain or loss of energy by parcels of the fluid material through absorption or emission of radiation are sufficient to change the pressure of the material, and therefore change its motion; alternatively, the net momentum exchange between radiation and matter may alter the motion of the matter directly. Ignoring the radiation contributions to energy and momentum will give a wrong prediction of the hydrodynamic motion when the correct description is radiation hydrodynamics. Of course, there are circumstances when a large quantity of radiation is present, yet can be ignored without causing the model to be in error. This happens when radiation from an exterior source streams through the problem, but the latter is so transparent that the energy and momentum coupling is negligible. Everything we say about radiation hydrodynamics applies equally well to neutrinos and photons (apart from the Einstein relations, specific to bosons), but in almost every area of astrophysics neutrino hydrodynamics is ignored, simply because the systems are exceedingly transparent to neutrinos, even though the energy flux in neutrinos may be substantial. Another place where we can do ''radiation hydrodynamics'' without using any sophisticated theory is deep within stars or other bodies, where the material is so opaque to the radiation that the mean free path of photons is entirely negligible compared with the size of the system, the distance over which any fluid quantity varies, and so on. In this case we can suppose that the radiation is in equilibrium with the matter locally, and its energy, pressure and momentum can be lumped in with those of the rest of the fluid. That is, it is no more necessary to distinguish photons from atoms, nuclei and electrons, than it is to distinguish hydrogen atoms from helium atoms, for instance. There are all just components of a mixed fluid in this case. So why do we have a special subject called ''radiation hydrodynamics'', when photons are just one of the many kinds of particles that comprise our fluid? The reason is that photons couple rather weakly to the atoms, ions and electrons, much more weakly than those particles couple with each other. Nor is the matter-radiation coupling negligible in many problems, since the star or nebula may be millions of mean free paths in extent. Radiation hydrodynamics exists as a discipline to treat those problems for which the energy and momentum coupling terms between matter and radiation are important, and for which, since the photon mean free path is neither extremely large nor extremely small compared with the size of the system, the radiation field is not very easy to calculate. In the theoretical development of this subject, many of the relations are presented in a form that is described as approximate, and perhaps accurate only to order of {nu}/c. This makes the discussion cumbersome. Why are we required to do this? It is because we are using Newtonian mechanics to treat our fluid, yet its photon component is intrinsically relativistic; the particles travel at the speed of light. There is a perfectly consistent relativistic kinetic theory, and a corresponding relativistic theory of fluid mechanics, which is perfectly suited to describing the photon gas. But it is cumbersome to use this for the fluid in general, and we prefer to avoid it for cases in which the flow velocity satisfies {nu} << c. The price we pay is to spend extra effort making sure that the source-sink terms relating to our relativistic gas component are included in the equations of motion in a form that preserves overall conservation of energy and momentum, something that would be automatic if the relativistic equations were used throughout.

Castor, J I

2003-10-16T23:59:59.000Z

202

Adaptive navigation for autonomous robots  

Science Conference Proceedings (OSTI)

In many robotic exploration missions, robots have to learn specific policies that allow them to: (i) select high level goals (e.g., identify specific destinations), (ii) navigate (reach those destinations), (iii) and adapt to their environment (e.g., ... Keywords: Learning, evolution, Learning, neural networks, Learning, single agent, Robotics, adaptation

Matt Knudson; Kagan Tumer

2011-06-01T23:59:59.000Z

203

Tightfit: adaptive parallelization with foresight  

Science Conference Proceedings (OSTI)

Irregular applications often exhibit data-dependent parallelism: Different inputs, and sometimes also different execution phases, enable different levels of parallelism. These changes in available parallelism have motivated work on adaptive concurrency ... Keywords: STM, adaptive software parallelization, data-dependent parallelism, irregular applications, offline learning

Omer Tripp; Noam Rinetzky

2013-08-01T23:59:59.000Z

204

Adaptive kernel principal component analysis  

Science Conference Proceedings (OSTI)

An adaptive kernel principal component analysis (AKPCA) method, which has the flexibility to accurately track the kernel principal components (KPC), is presented. The contribution of this paper may be divided into two parts. First, KPC are recursively ... Keywords: Adaptive method, Kernel principal component, Kernel principal component analysis, Non-stationary data, Recursive algorithm

Mingtao Ding; Zheng Tian; Haixia Xu

2010-05-01T23:59:59.000Z

205

Protein Structure Suggests Role as Molecular Adapter  

NLE Websites -- All DOE Office Websites (Extended Search)

Protein Structure Suggests Role Protein Structure Suggests Role as Molecular Adapter Protein Structure Suggests Role as Molecular Adapter Print Wednesday, 24 June 2009 00:00 To split and copy DNA during replication, all cellular organisms use a multicomponent molecular machine known as the replisome. An essential step in replisome assembly is the loading of ring-shaped helicases (motor proteins) onto the separated strands of DNA. Dedicated ATP-fueled proteins regulate the loading; however, the mechanism by which these proteins recruit and deposit helicases has remained unclear. To better understand this process, researchers at the University of California, Berkeley, recently determined the structure of the ATPase region of DnaC, a bacterial helicase loader. The structure revealed that DnaC is a close cousin of DnaA, the protein thought to be responsible for unwinding DNA. Unexpectedly, the team further found that DnaC forms a right-handed helix similar to the state adopted by ATP-bound DnaA. These findings, together with biochemical studies, implicate DnaC as a molecular adapter that uses ATP-activated DnaA as a docking site for ensuring that DnaB (the ring-shaped helicase) is correctly deposited at the onset of replication.

206

RADIATION DETECTOR  

DOE Patents (OSTI)

A radiation detector of the type is described wherein a condenser is directly connected to the electrodes for the purpose of performing the dual function of a guard ring and to provide capacitance coupling for resetting the detector system.

Wilson, H.N.; Glass, F.M.

1960-05-10T23:59:59.000Z

207

NIST Radiation thermometry  

Science Conference Proceedings (OSTI)

Radiation thermometry. Summary: ... Description: Radiation thermometers are calibrated using a range of variable-temperature blackbodies. ...

2011-10-13T23:59:59.000Z

208

NIST Optical Radiation Group  

Science Conference Proceedings (OSTI)

Optical Radiation Group. Welcome. The Optical Radiation Group maintains, improves, and disseminates the national scales ...

2013-07-29T23:59:59.000Z

209

The low dose damage response pathways in the mouse mammary glands depends  

NLE Websites -- All DOE Office Websites (Extended Search)

low dose damage response pathways in the mouse mammary glands depends low dose damage response pathways in the mouse mammary glands depends on genotype, tissue compartment, exposure regimen, and sampling times Joe Gray & Andrew Wyrobek Lawrence Berkeley National Laboratory Abstract The objectives of this research are to characterize the early and persistent low-dose and adaptive response (AR) damage surveillance networks in mammary glands of radiation sensitive and resistant strains of mice to identify the molecular signatures/mechanisms associated with nonlinear modifications of risk for mammary gland cancer. Our approach uses low-dose exposure regimens that have been reported to induce mammary gland cancer in sensitive strains to determine whether low-dose induced pathways are differentially expressed in epithelial or stromal cells and to determine

210

Dynamic adaptive data structures for monitoring data streams  

Science Conference Proceedings (OSTI)

The monitoring of data streams is a very important issue in many different areas. Aspects such as accuracy, the speed of response, the use of memory and the adaptability to the changing nature of data may vary in importance depending on the situation. ... Keywords: Bloom filters, Data streams, Data structures

J. Aguilar-Saborit; P. Trancoso; V. Muntes-Mulero; J. L. Larriba-Pey

2008-07-01T23:59:59.000Z

211

Adaptive Markets and the New World Order  

E-Print Network (OSTI)

In the adaptive markets hypothesis (AMH) intelligent but fallible investors learn from and adapt to changing economic environments. This implies that markets are not always efficient but are usually competitive and adaptive, ...

Lo, Andrew W.

212

Damage detection by an adaptive real-parameter simulated annealing genetic algorithm  

Science Conference Proceedings (OSTI)

An effective algorithm, which combined an adaptive real-parameter genetic algorithm with simulated annealing, is proposed to detect damage occurrence in beam-type structures. The proposed algorithm uses the displacements of static response and natural ... Keywords: Adaptive mechanism, Damage detection, Genetic algorithm, Optimization, Simulated annealing

Rong-Song He; Shun-Fa Hwang

2006-12-01T23:59:59.000Z

213

Computational phenotype prediction of ionizing-radiation-resistant bacteria with a multiple-instance learning model  

Science Conference Proceedings (OSTI)

Ionizing-radiation-resistant bacteria (IRRB) are important in biotechnology. The use of these bacteria for the treatment of radioactive wastes is determined by their surprising capacity of adaptation to radionuclides and a variety of toxic molecules. ... Keywords: ionizing-radiation-resistant bacteria, ionizing-radiation-sensitive bacteria, multiple-instance learning, phenotypic prediction, protein sequences

Sabeur Aridhi; Mondher Maddouri; Haitham Sghaier; Engelbert Mephu Nguifo

2013-08-01T23:59:59.000Z

214

Low-Dose/Dose-Rate Low-LET Radiation Protects Us from Cancer  

NLE Websites -- All DOE Office Websites (Extended Search)

Dose/Dose-Rate Low-LET Radiation Protects Us from Cancer Dose/Dose-Rate Low-LET Radiation Protects Us from Cancer Bobby R. Scott, Ph.D. and Jennifer D. Di Palma Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE Albuquerque, NM 87108 USA Life on earth evolved in a low-level ionizing radiation environment comprised of terrestrial radiation and cosmic rays. Today we all reside in an ionizing radiation environment comprised of both natural background radiation and radiation from human activities (e.g., Chernobyl accident). An evolutionary benefit of the interaction of low-level, low linear-energy-transfer (LET) ionizing radiation with mammalian life forms on earth is adapted protection. Adapted protection involves low-dose/dose-rate, low-LET radiation induced high-fidelity DNA repair in cooperation with normal apoptosis (presumed p53

215

Effect of light intensity on photosynthesis by thermal algae adapted to natural and reduced  

E-Print Network (OSTI)

Thermal algae in alkaline hot springs of Yellowstone National Park (Wyoming) grow as compact mats in which self-shading is extensive, as shown by measurement by autoradiog-raphy of photosynthetic activity of cells at different levels in the mat. The effect of light intensity on photosynthesis of the algal mats was studied using neutral density filters during incubation with lCO Despite the intense sunlight at the altitude of Yellowstone, light inhibition by full sur$ght was observed only occasionally; the rate of photosynthesis fell progressively with decreasing light, although the most efficient use was at 7-14s of full sunlight. Later, the light intensity over portions of the algal mats was reduced to 18 % of full sunlight by installing neutral density glass plates, and changes of chlorophyll content, cell number, and response of photosynthesis to light intensity were determined over the next year. Although the chlorophyll content of the algae at the surface of the mat rose quickly, the chlorophyll content of the mat as a whole rose slowly or not at all; the photosynthetic response of the algal mats to full and reduced sunlight also changed slowly or not at all. Although individual algal cells can adapt rapidly to changes in light, the entire population, because of its existence in compact mats, adapts slowly. At the latitude of Yellowstone there is sufficient light throughout the year to enable algal growth to occur even at temperatures near the upper limit at which blue-green algae can grow; in Iceland, hot spring algae cannot grow during several winter months. Natural ultraviolet radiation neither inhibited nor stimulated photosynthesis.

Thomas D. Brock; M. Louise Brock

1969-01-01T23:59:59.000Z

216

African Adaptation Programme | Open Energy Information  

Open Energy Info (EERE)

Adaptation Programme Adaptation Programme Jump to: navigation, search Logo: African Adaptations Programme Name African Adaptations Programme Agency/Company /Organization United Nations Development Programme, Government of Japan Topics Adaptation, Finance, Implementation, Policies/deployment programs Website http://www.undp-adaptation.org References AAP[1] Overview "UNDP, with funding from the Government of Japan, recently launched a new programme that uses an innovative approach to climate change adaptation in Africa. Under this programme, UNDP will assist 21 African countries in implementing integrated and comprehensive adaptation actions and resilience plans. The projects will ensure that national development processes incorporate climate change risks and opportunities to secure development gains under a

217

A Dynamic Platform for Runtime Adaptation  

E-Print Network (OSTI)

We present a middleware platform for assembling pervasive applications that demand fault-tolerance and adaptivity in distributed, dynamic environments. Unlike typical adaptive middleware approaches, in which sophisticated ...

Pham, Hubert

218

Adaptive Materials Inc | Open Energy Information  

Open Energy Info (EERE)

Zip MI 48108 Product Adaptive Materials Inc (AMI) is a developer of portable fuel cell technology. References Adaptive Materials Inc1 LinkedIn Connections CrunchBase...

219

Mainstreaming Climate Change Adaptation into Development Planning...  

Open Energy Info (EERE)

Mainstreaming Climate Change Adaptation into Development Planning: A Guide for Practitioners Jump to: navigation, search Tool Summary Name: Mainstreaming Climate Change Adaptation...

220

Optimal adaptive control with ?LQG.  

E-Print Network (OSTI)

??This thesis introduces ?LQG, the hyper extension of the Linear Quadratic Gaussian Regulator, for solving general purpose (locally optimal) nonlinear adaptive control on multiple-input multiple-output (more)

Wendt, Luke

2013-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Radiation receiver  

DOE Patents (OSTI)

The apparatus for collecting radiant energy and converting same to alternate energy form includes a housing having an interior space and a radiation transparent window allowing, for example, solar radiation to be received in the interior space of the housing. Means are provided for passing a stream of fluid past said window and for injecting radiation absorbent particles in said fluid stream. The particles absorb the radiation and because of their very large surface area, quickly release the heat to the surrounding fluid stream. The fluid stream particle mixture is heated until the particles vaporize. The fluid stream is then allowed to expand in, for example, a gas turbine to produce mechanical energy. In an aspect of the present invention properly sized particles need not be vaporized prior to the entrance of the fluid stream into the turbine, as the particles will not damage the turbine blades. In yet another aspect of the invention, conventional fuel injectors are provided to inject fuel into the fluid stream to maintain the proper temperature and pressure of the fluid stream should the source of radiant energy be interrupted. In yet another aspect of the invention, an apparatus is provided which includes means for providing a hot fluid stream having hot particles disbursed therein which can radiate energy, means for providing a cooler fluid stream having cooler particles disbursed therein, which particles can absorb radiant energy and means for passing the hot fluid stream adjacent the cooler fluid stream to warm the cooler fluid and cooler particles by the radiation from the hot fluid and hot particles. 5 figs.

Hunt, A.J.

1983-09-13T23:59:59.000Z

222

Radiation receiver  

SciTech Connect

The apparatus for collecting radiant energy and converting same to alternate energy form includes a housing having an interior space and a radiation transparent window allowing, for example, solar radiation to be received in the interior space of the housing. Means are provided for passing a stream of fluid past said window and for injecting radiation absorbent particles in said fluid stream. The particles absorb the radiation and because of their very large surface area, quickly release the heat to the surrounding fluid stream. The fluid stream particle mixture is heated until the particles vaporize. The fluid stream is then allowed to expand in, for example, a gas turbine to produce mechanical energy. In an aspect of the present invention properly sized particles need not be vaporized prior to the entrance of the fluid stream into the turbine, as the particles will not damage the turbine blades. In yet another aspect of the invention, conventional fuel injectors are provided to inject fuel into the fluid stream to maintain the proper temperature and pressure of the fluid stream should the source of radiant energy be interrupted. In yet another aspect of the invention, an apparatus is provided which includes means for providing a hot fluid stream having hot particles disbursed therein which can radiate energy, means for providing a cooler fluid stream having cooler particles disbursed therein, which particles can absorb radiant energy and means for passing the hot fluid stream adjacent the cooler fluid stream to warm the cooler fluid and cooler particles by the radiation from the hot fluid and hot particles.

Hunt, Arlon J. (Oakland, CA)

1983-01-01T23:59:59.000Z

223

RADIATION SOURCES  

DOE Patents (OSTI)

A novel long-lived source of gamma radiation especially suitable for calibration purposes is described. The source of gamma radiation is denoted mock iodine131, which comprises a naixture of barium-133 and cesium-137. The barium and cesium are present in a barium-cesium ratio of approximately 5.7/1 to 14/1, uniformly dispersed in an ion exchange resin and a filter surrounding the resin comprised of a material of atomic number below approximately 51, and substantially 0.7 to 0.9 millimeter thick.

Brucer, M.H.

1958-04-15T23:59:59.000Z

224

Radiation Damage in Nanostructured Metallic Films  

E-Print Network (OSTI)

High energy neutron and charged particle radiation cause microstructural and mechanical degradation in structural metals and alloys, such as phase segregation, void swelling, embrittlement and creep. Radiation induced damages typically limit nuclear materials to a lifetime of about 40 years. Next generation nuclear reactors require materials that can sustain over 60 - 80 years. Therefore it is of great significance to explore new materials with better radiation resistance, to design metals with favorable microstructures and to investigate their response to radiation. The goals of this thesis are to study the radiation responses of several nanostructured metallic thin film systems, including Ag/Ni multilayers, nanotwinned Ag and nanocrystalline Fe. Such systems obtain high volume fraction of boundaries, which are considered sinks to radiation induced defects. From the viewpoint of nanomechanics, it is of interest to investigate the plastic deformation mechanisms of nanostructured films, which typically show strong size dependence. By controlling the feature size (layer thickness, twin spacing and grain size), it is applicable to picture a deformation mechanism map which also provides prerequisite information for subsequent radiation hardening study. And from the viewpoint of radiation effects, it is of interest to explore the fundamentals of radiation response, to examine the microstructural and mechanical variations of irradiated nanometals and to enrich the design database. More importantly, with the assistance of in situ techniques, it is appealing to examine the defect generation, evolution, annihilation, absorption and interaction with internal interfaces (layer interfaces, twin boundaries and grain boundaries). Moreover, well-designed nanostructures can also verify the speculation that radiation induced defect density and hardening show clear size dependence. The focus of this thesis lies in the radiation response of Ag/Ni multilayers and nanotwinned Ag subjected to charged particles. The radiation effects in irradiated nanograined Fe are also investigated for comparison. Radiation responses in these nanostructured metallic films suggest that immiscible incoherent Ag/Ni multilayers are more resistant to radiation in comparison to their monolithic counterparts. Their mechanical properties and radiation response show strong layer thickness dependence in terms of radiation hardening and defect density. Coherent twin boundaries can interact with stacking fault tetrahedral and remove them effectively. Twin boundaries can actively absorb radiation induced defects and defect clusters resulting in boundary migration. Size dependence is also found in nanograins where fewer defects exhibit in films with smaller grains.

Yu, Kaiyuan

2013-05-01T23:59:59.000Z

225

Emerging patterns of adaptive re-use : the new American House Hotel  

E-Print Network (OSTI)

This thesis aims to develop a design solution for the adaptive reuse of the American House Hotel that answers an architectural design challenge with technical responses. The process of actualization has been pushed a bit ...

Moody, Linda A

1984-01-01T23:59:59.000Z

226

Genetic, cell-type, and tissue variation in low-dose and adaptive...  

NLE Websites -- All DOE Office Websites (Extended Search)

goals are to understand the low-dose and adaptive response mechanisms of the mammary gland in order to build a mechanistic model for predicting an individuals risk for...

227

Genetic, cell-type, and tissue variation in low-dose and adaptive...  

NLE Websites -- All DOE Office Websites (Extended Search)

goals are to understand the low-dose and adaptive response mechanisms of the mammary gland in order to build a mechanistic model for predicting an individual's risk for breast...

228

Making climate adaptation work : strategies for resource constrained South Asian mega-cities  

E-Print Network (OSTI)

This dissertation compares the responses of Dhaka, Bangladesh and Kolkata, India to the serious challenges posed by climate change, particularly in the water sector. Drawing on the theories of "adaptation as development" ...

Dutta-Koehler, Madhu Chhanda

2013-01-01T23:59:59.000Z

229

Learning from Climate Variability: Adaptive Governance and the Pacific ENSO Applications Center  

Science Conference Proceedings (OSTI)

Adaptive governance is a pattern that began to emerge from conflicts over natural resources in the American West a few decades ago. This was a pragmatic response to the emerging evidence that effective control was dispersed among multiple ...

Amanda H. Lynch; Ronald D. Brunner

2010-10-01T23:59:59.000Z

230

Comparison of control algorithms for a MEMS-based adaptive optics scanning laser ophthalmoscope  

Science Conference Proceedings (OSTI)

We compared four algorithms for controlling a MEMS deformable mirror of an adaptive optics (AO) scanning laser ophthalmoscope. Interferometer measurements of the static nonlinear response of the deformable mirror were used to form an equivalent linear ...

Kaccie Y. Li; Sandipan Mishra; Pavan Tiruveedhula; Austin Roorda

2009-06-01T23:59:59.000Z

231

Adaptive control for energy conservation  

DOE Green Energy (OSTI)

The use of adaptive control techniques is investigated in heating, ventilating, and air cnditioning (HVAC) systems in solar heated and cooled buildings to minimize the consumption of auxiliary energy. Optimal control theory is used in conjunction with the adaptive control techniques to accomplish the minimization of auxiliary energy. The resulting technique is referred to as adaptive optimal control (AOC). This study has been made by computer simulation and is centered on the National Security and Resources Study Center (NSRSC), a large solar heated and cooled building at the Los Alamos Scientific Laboratory (LASL). Simplified models of the building and HVAC system have been developed for both the heating and cooling modes. The control strategies actually used in the NSRSC were simulated in the models and an adaptive optimal controller was developed and also simulated. Simulation runs were made with both the conventional controller and the adaptive controller and performance results of the two simulations were compared. In the first results (obtained using a partial derivative system identification method), the adaptive optimal controller model demonstrated a savings in auxiliary energy of 28.8% for the heating simulation and 18.3% for the cooling simulation when compared to the conventional controller simulation models.

Farris, D.R.

1978-01-01T23:59:59.000Z

232

WeADAPT | Open Energy Information  

Open Energy Info (EERE)

WeADAPT WeADAPT Jump to: navigation, search Name WeADAPT Agency/Company /Organization weADAPT Sector Energy, Land, Water, Climate Resource Type Training materials, Lessons learned/best practices Website http://www.weadapt.org/ References weADAPT[1] "weADAPT.org is an online 'open space' on climate adaptation issues (including the synergies between adaptation and mitigation) which allows practitioners, researchers and policy makers to access credible, high quality information and to share experiences and lessons learnt with the weADAPT community. It is designed to facilitate learning, exchange, collaboration and knowledge integration to build a professional community of practice on adaptation issues while developing policy-relevant tools and guidance for adaptation planning and decision-making.

233

AfricaAdapt | Open Energy Information  

Open Energy Info (EERE)

AfricaAdapt AfricaAdapt Jump to: navigation, search Logo: Africa Adapt Name Africa Adapt Agency/Company /Organization AfricaAdapt Resource Type Training materials, Lessons learned/best practices Website http://www.africa-adapt.net/AA UN Region Eastern Africa, Middle Africa, Northern Africa, Southern Africa, Western Africa References AfricaAdapt[1] Abstract AfricaAdapt is an independent bilingual network (French/English) focused exclusively on Africa. The Network's aim is to facilitate the flow of climate change adaptation knowledge for sustainable livelihoods between researchers, policy makers, civil society organisations and communities who are vulnerable to climate variability and change across the continent. Africa Adapt Screenshot "AfricaAdapt is an independent bilingual network (French/English) focused

234

The influence of tropical adaptation and breedtype on adrenal and testicular function in beef bulls  

E-Print Network (OSTI)

Bulls of various breedtypes including Angus (Bos taurus), Bonsmara (Sanga X Bos taurus), Brahman (Bos indicus), Romosinuano (Criollo), Tuli (Sanga) and Wagyu (Japanese Bos taurus) were utilized to evaluate the influence of tropical adaptation on adrenal and testicular function. The objectives were to determine if tropical adaptation influenced: a) response to management stressors, b) organ and gland weights, adrenal and testis StAR and P450 content and total adrenal, medullary and cortical areas, c) basal and hCG-induced testosterone and d) testis and epididymal sperm concentrations. Blood samples were obtained within 5 min before and after transportation and during restraint every 15 min for 6 h to evaluate cortical response. Angus, Brahman and Romosinuano bulls were slaughtered following sexual maturity. Cortical responses to transportation and restraint were not influenced by tropical adaptation. Response to these stressors could be categorized into high responders (Angus, Brahman), intermediate responders (Romosinuano, Tuli) and low responders (Wagyu, Bonsmara). Tropically-adapted breedtypes were not categorized into a single group; therefore, cortical responses to management stressors were influenced by breedtype, but not by tropical adaptation. Most organ and gland weights (actual weight and weight corrected for BW) and the steroid precursors, StAR and P450, were not influenced by tropical adaptation, but were by breedtype. Paired adrenal gland weight, total adrenal area, medullary and cortical areas were influenced by tropical adaptation. Tropically-adapted breedtypes had lighter glands and smaller areas than the temperate Bos taurus breedtypes. All breedtypes except Wagyu had similar basal concentrations of plasma testosterone prior to hCG administration; therefore, basal testosterone was not influenced by tropical adaptation, but only by breedtype. Wagyu had greater basal concentrations of testosterone than other breedtypes. Testosterone concentrations following hCG administration was similar between adaptation groups and breedtypes. As expected, testis and epididymal sperm concentrations were influenced by tropical adaptation. Tropically-adapted breedtypes had greater testicular and epididymal sperm concentrations than the temperate Bos taurus breedtypes during the summer months. In summary, adrenal weight and area and testicular and epididymal sperm concentrations were influenced by tropical adaptation. Cortical response to management stressors, basal testosterone and StAR and P450 content were influenced by breedtype, not tropical adaptation.

Koch, Jeffrey William

2005-05-01T23:59:59.000Z

235

Irradiators for measuring the biological effects of low dose-rate ionizing radiation fields  

E-Print Network (OSTI)

Biological response to ionizing radiation differs with radiation field. Particle type, energy spectrum, and dose-rate all affect biological response per unit dose. This thesis describes methods of spectral analysis, ...

Davidson, Matthew Allen

2011-01-01T23:59:59.000Z

236

Radiation Protection Act (Pennsylvania)  

Energy.gov (U.S. Department of Energy (DOE))

This Act combines the radiation safety provisions of The Atomic Energy Development and Radiation Control Act and the Environmental Radiation Protection Act, and empowers the Department of...

237

Radiation Tolerant Metallic Multilayers  

Science Conference Proceedings (OSTI)

Strategies that can alleviate radiation damage may assist the design of radiation tolerant materials. We will summarize our recent studies on radiation damage in...

238

NEW SOURCES OF RADIATION  

E-Print Network (OSTI)

Stanford Synchrotron Radiation Project Report No. 75/07.IBL 79M0733 Fig. 20. Radiation emission pattern by electronsWinick, Stanford Synchrotron Radiation Laboratory. Fig. 21.

Schimmerling, W.

2010-01-01T23:59:59.000Z

239

Radiation-induced angiosarcoma  

E-Print Network (OSTI)

1a Figure 1b Figure 1. Radiation-induced angiosarcoma in afollowing completion of radiation therapy. Figure 2a Figurecell histiocytosis after radiation for breast carcinoma: can

Anzalone, C Lane; Cohen, Philip R; Diwan, Abdul H; Prieto, Victor G

2013-01-01T23:59:59.000Z

240

Adaptive Liquid Crystal Windows  

SciTech Connect

Energy consumption by private and commercial sectors in the U.S. has steadily grown over the last decade. The uncertainty in future availability of imported oil, on which the energy consumption relies strongly, resulted in a dramatic increase in the cost of energy. About 20% of this consumption are used to heat and cool houses and commercial buildings. To reduce dependence on the foreign oil and cut down emission of greenhouse gases, it is necessary to eliminate losses and reduce total energy consumption by buildings. To achieve this goal it is necessary to redefine the role of the conventional windows. At a minimum, windows should stop being a source for energy loss. Ideally, windows should become a source of energy, providing net gain to reduce energy used to heat and cool homes. It is possible to have a net energy gain from a window if its light transmission can be dynamically altered, ideally electronically without the need of operator assistance, providing optimal control of the solar gain that varies with season and climate in the U.S. In addition, the window must not require power from the building for operation. Resolution of this problem is a societal challenge and of national interest and will have a broad global impact. For this purpose, the year-round, allclimate window solution to provide an electronically variable solar heat gain coefficient (SHGC) with a wide dynamic range is needed. AlphaMicron, Inc. (AMI) developed and manufactured 1ft 1ft prototype panels for the worlds first auto-adjusting Adaptive Liquid Crystal Windows (ALCWs) that can operate from sunlight without the need for external power source and demonstrate an electronically adjustable SHGC. This novel windows are based on AlphaMicrons patented e-Tint technology, a guesthost liquid crystal system implemented on flexible, optically clear plastic films. This technology is suitable both for OEM and aftermarket (retro-fitting) lamination to new and existing windows. Low level of power consumption by ALCWs allows for on-board power electronics for automatic matching of transmission through windows to varying climate conditions without drawing the power from the power grid. ALCWs are capable of transmitting more sunlight in winters to assist in heating and less sunlight in summers to minimize overheating. As such, they can change the window from being a source of energy loss to a source of energy gain. In addition, the scalable AMIs roll-to-roll process, proved by making 1ft 1ftALCW prototype panels, allows for cost-effective production of large-scale window panels along with capability to change easily their color and shape. In addition to architectural glazing in houses and commercial buildings, ALCWs can be used in other applications where control of sunlight is needed, such as green houses, used by commercial produce growers and botanical gardens, cars, aircrafts, etc.

Taheri, Bahman; Bodnar, Volodymyr

2011-12-31T23:59:59.000Z

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Integrated Experimental and Computational Approach to Understand the Effects of Heavy Ion Radiation on Skin Homeostasis.  

SciTech Connect

The effects of low dose high linear energy transfer (LET) radiation on human health are of concern for both space and clinical exposures. As epidemiological data for such radiation exposures are scarce for making relevant predictions, we need to understand the mechanism of response especially in normal tissues. Our objective here is to understand the effects of heavy ion radiation on tissue homeostasis in a realistic model system. Towards this end, we exposed an in vitro three dimensional skin equivalent to low fluences of Neon (Ne) ions (300 MeV/u), and determined the differentiation profile as a function of time following exposure using immunohistochemistry. We found that Ne ion exposures resulted in transient increases in the tissue regions expressing the differentiation markers keratin 10, and filaggrin, and more subtle time-dependent effects on the number of basal cells in the epidermis. We analyzed the data using a mathematical model of the skin equivalent, to quantify the effect of radiation on cell proliferation and differentiation. The agent-based mathematical model for the epidermal layer treats the epidermis as a collection of heterogeneous cell types with different proliferation/differentiation properties. We obtained model parameters from the literature where available, and calibrated the unknown parameters to match the observed properties in unirradiated skin. We then used the model to rigorously examine alternate hypotheses regarding the effects of high LET radiation on the tissue. Our analysis indicates that Ne ion exposures induce rapid, but transient, changes in cell division, differentiation and proliferation. We have validated the modeling results by histology and quantitative reverse transcription polymerase chain reaction (qRT-PCR). The integrated approach presented here can be used as a general framework to understand the responses of multicellular systems, and can be adapted to other epithelial tissues.

von Neubeck, Claere; Shankaran, Harish; Geniza, Matthew; Kauer, Paula M.; Robinson, Robert J.; Chrisler, William B.; Sowa, Marianne B.

2013-08-08T23:59:59.000Z

242

Adaptive vibration control using synchronous demodulation with ...  

Adaptive vibration control using synchronous demodulation with machine tool controller motor commutation United States Patent

243

Checking Properties of Adaptive Workflow Nets  

Science Conference Proceedings (OSTI)

In this paper we consider adaptive workflow nets, a class of nested nets that allows more comfort and expressive power for modeling adaptability and exception handling in workflow nets. We define two important behavioural properties of adaptive workflow ... Keywords: adaptive workflow, circumspectness, soundness, verification

Kees van Hee; Olivia Oanea; Alexander Serebrenik; Natalia Sidorova; Marc Voorhoeve; Irina A. Lomazova

2008-02-01T23:59:59.000Z

244

Adaptive Urban Dispersion Integrated Model  

DOE Green Energy (OSTI)

Numerical simulations represent a unique predictive tool for understanding the three-dimensional flow fields and associated concentration distributions from contaminant releases in complex urban settings (Britter and Hanna 2003). Utilization of the most accurate urban models, based on fully three-dimensional computational fluid dynamics (CFD) that solve the Navier-Stokes equations with incorporated turbulence models, presents many challenges. We address two in this work; first, a fast but accurate way to incorporate the complex urban terrain, buildings, and other structures to enforce proper boundary conditions in the flow solution; second, ways to achieve a level of computational efficiency that allows the models to be run in an automated fashion such that they may be used for emergency response and event reconstruction applications. We have developed a new integrated urban dispersion modeling capability based on FEM3MP (Gresho and Chan 1998, Chan and Stevens 2000), a CFD model from Lawrence Livermore National Lab. The integrated capability incorporates fast embedded boundary mesh generation for geometrically complex problems and full three-dimensional Cartesian adaptive mesh refinement (AMR). Parallel AMR and embedded boundary gridding support are provided through the SAMRAI library (Wissink et al. 2001, Hornung and Kohn 2002). Embedded boundary mesh generation has been demonstrated to be an automatic, fast, and efficient approach for problem setup. It has been used for a variety of geometrically complex applications, including urban applications (Pullen et al. 2005). The key technology we introduce in this work is the application of AMR, which allows the application of high-resolution modeling to certain important features, such as individual buildings and high-resolution terrain (including important vegetative and land-use features). It also allows the urban scale model to be readily interfaced with coarser resolution meso or regional scale models. This talk will discuss details of the approach and present results for some example calculations performed in Manhattan in support of the DHS Urban Dispersion Program (UDP) using some of the tools developed as part of this new capability.

Wissink, A; Chand, K; Kosovic, B; Chan, S; Berger, M; Chow, F K

2005-11-03T23:59:59.000Z

245

Automated Grid Disruption Response System: Robust Adaptive Topology Control (RATC)  

SciTech Connect

GENI Project: The RATC research team is using topology control as a mechanism to improve system operations and manage disruptions within the electric grid. The grid is subject to interruption from cascading faults caused by extreme operating conditions, malicious external attacks, and intermittent electricity generation from renewable energy sources. The RATC system is capable of detecting, classifying, and responding to grid disturbances by reconfiguring the grid in order to maintain economically efficient operations while guaranteeing reliability. The RATC system would help prevent future power outages, which account for roughly $80 billion in losses for businesses and consumers each year. Minimizing the time it takes for the grid to respond to expensive interruptions will also make it easier to integrate intermittent renewable energy sources into the grid.

None

2012-03-01T23:59:59.000Z

246

Adaptable architecture : a computational exploration into responsive design systems  

E-Print Network (OSTI)

Based on the fact that architecture is, among other things, the crystallization of a mediation among design intentions (function), meaning and contextual constraints (performance), we as designers are obligated to produce ...

Zulas, Alejandro, 1976-

2004-01-01T23:59:59.000Z

247

Method of improving high-purity germanium radiation detectors  

DOE Patents (OSTI)

A method for improving the response characteristics of highpurity germanium radiation detectors by irradiation, annealing and etching is presented. (Official Gazette)

Llacer, J.; Kraner, H.W.

1973-12-25T23:59:59.000Z

248

Low Dose Radiation Research Program: Depletion of the Vertebrate...  

NLE Websites -- All DOE Office Websites (Extended Search)

Laboratory, Berkeley, California To better understand the responses to low dose ionizing radiation, we proposed in Aim 1 of our Low Dose grant to use dominant-negative...

249

Low Dose Radiation Research Program: Genetic Variation in Tissue...  

NLE Websites -- All DOE Office Websites (Extended Search)

Variation in Tissue Responses to Low-dose Radiation Eugene Rinchik Oak Ridge National Laboratory Why this Project? To address how individual genetic background affects tissue...

250

Louisiana Nuclear Energy and Radiation Control Law (Louisiana)  

Energy.gov (U.S. Department of Energy (DOE))

The Louisiana Department of Environmental Quality is responsible for the regulation of nuclear energy safety, permitting and radiation safety and control in Louisiana. The Department operates...

251

Radiation properties of cavity Cerenkov radiation  

SciTech Connect

Cerenkov radiation from cavities has been analyzed by quantum electrodynamic theory. Analytical expressions of basic radiation properties such as the Einstein's A and B coefficients are derived and shown to be directly modified by the cavities. The analysis leads to the conclusion that the coherent radiation from the Cerenkov radiation devices is due to super radiance of spontaneous emission instead of stimulated emission. Coherent and incoherent radiations are analyzed in the THz radiation range.

Gao Ju; Shen Fang [Electrical and Computer Engineering Department, University of Illinois, Urbana, Illinois 61801 (United States)

2006-04-15T23:59:59.000Z

252

Adaptive hybrid impedance control of robot manipulators: a comparative study  

Science Conference Proceedings (OSTI)

Keywords: direct adaptive control, hybrid impedance control, passivity-based adaptive control, robotics

Lus F. Baptista; Jos M. G. S da Costa

1997-01-01T23:59:59.000Z

253

Low Dose Radiation Research Program: Thomas Weber  

NLE Websites -- All DOE Office Websites (Extended Search)

2005 Workshop: A Paracrine Signal Mediates The Cell Transformation Response To Low Dose Gamma Radiation in JB6 Cells. Weber, T.J., Siegel, R.W., Markillie, L.M., Chrisler,...

254

Low Dose Radiation Research Program: Molecular Characterization...  

NLE Websites -- All DOE Office Websites (Extended Search)

the Role of SOD Genes in Mammalian Cellular Response to Low Dose Ionizing Radiation Chaun-Yuan Li Duke University Medical Center Durham, NC Why this Project? To evaluate the roles...

255

Geant4 applications in the heliospheric radiation environment  

E-Print Network (OSTI)

The high energy ionizing radiation environment in the solar system consists of three main sources: the radiation belts, galactic cosmic rays and solar energetic particles. Geant4 is a Monte Carlo radiation transport simulation toolkit, with applications in areas as high energy physics, nuclear physics, astrophysics or medical physics research. In this poster, Geant4 applications to model and study the effects of the heliospheric radiation environment are presented. Specific applications are being developed to study the effect of the radiation environment on detector components, to describe the response and to optimise the design of radiation monitors for future space missions and to predict the radiation environment in Mars surface, orbits and moons.

Pedro Brogueira; Patrcia Gonalves; Ana Keating; Dalmiro Maia; Mrio Pimenta; Bernardo Tom

2007-09-11T23:59:59.000Z

256

Information Theoretic Adaptive Tracking of Epidemics in Complex Networks  

E-Print Network (OSTI)

Adaptively monitoring the states of nodes in a large complex network is of interest in domains such as national security, public health, and energy grid management. Here, we present an information theoretic adaptive tracking and sampling framework that recursively selects measurements using the feedback from performing inference on a dynamic Bayesian Network. We also present conditions for the existence of a network specific, observation dependent, phase transition in the updated posterior of hidden node states resulting from actively monitoring the network. Since traditional epidemic thresholds are derived using observation independent Markov chains, the threshold of the posterior should more accurately model the true phase transition of a network. The adaptive tracking framework and epidemic threshold should provide insight into modeling the dynamic response of the updated posterior to active intervention and control policies while monitoring modern complex networks.

Harrington, Patrick L

2013-01-01T23:59:59.000Z

257

RADIATION LABORATO DISCLAIMER  

NLE Websites -- All DOE Office Websites (Extended Search)

R : R : . . . RADIATION LABORATO DISCLAIMER This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency Thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or any

258

Radiation Pressure in Massive Star Formation  

E-Print Network (OSTI)

Stars with masses of >~ 20 solar masses have short Kelvin times that enable them to reach the main sequence while still accreting from their natal clouds. The resulting nuclear burning produces a huge luminosity and a correspondingly large radiation pressure force on dust grains in the accreting gas. This effect may limit the upper mass of stars that can form by accretion. Indeed, simulations and analytic calculations to date have been unable to resolve the mystery of how stars of 50 solar masses and up form. We present two new ideas to solve the radiation pressure problem. First, we use three-dimensional radiation hydrodynamic adaptive mesh refinement simulations to study the collapse of massive cores. We find that in three dimensions a configuration in which radiation holds up an infalling envelope is Rayleigh-Taylor unstable, leading radiation driven bubbles to collapse and accretion to continue. We also present Monte Carlo radiative transfer calculations showing that the cavities created by protostellar winds provides a valve that allow radiation to escape the accreting envelope, further reducing the ability of radiation pressure to inhibit accretion.

Mark R. Krumholz; Richard I. Klein; Christopher F. McKee

2005-10-14T23:59:59.000Z

259

Types of Radiation Exposure  

NLE Websites -- All DOE Office Websites (Extended Search)

External Irradiation Contamination Incorporation Biological Effects of Acute, Total Body Irradiation Managing Radiation Emergencies Procedure Demonstration Types of radiation...

260

Radiation Effects In Ceramics  

Science Conference Proceedings (OSTI)

RADIATION MATERIALS SCIENCE IN TECHNOLOGY APPLICATIONS II: Radiation Effects in Ceramics. Sponsored by: Jt. SMD/MSD Nuclear Materials...

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Ionizing Radiation Dosimetry  

Science Conference Proceedings (OSTI)

Ionizing Radiation Dosimetry. ... OH. US Air Force Radiation Dosimetry Laboratory, Wright-Patterson - Base, OH [100548- 0] PA. ...

2013-09-06T23:59:59.000Z

262

Radiation Physics Division  

Science Conference Proceedings (OSTI)

... The Radiation Physics Division, part of the Physical Measurement Laboratory ... the measurement standards for ionizing radiations and radioactivity ...

2013-09-05T23:59:59.000Z

263

Mechanism underlying mTOR-associated Protection in Low Dose Radiation...  

NLE Websites -- All DOE Office Websites (Extended Search)

low-dose radiation-induced adaptive resistance. Oncogene 27: 6738-6748. 2. Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, and Shaw RJ. (2008). AMPK...

264

Full-Spectrum Correlated-k Distribution for Shortwave Atmospheric Radiative Transfer  

Science Conference Proceedings (OSTI)

The full-spectrum correlated k-distribution (FSCK) method, originally developed for applications in combustion systems, is adapted for use in shortwave atmospheric radiative transfer. By weighting k distributions by the solar source function, the ...

Daniel T. Pawlak; Eugene E. Clothiaux; Michael F. Modest; Jason N. S. Cole

2004-11-01T23:59:59.000Z

265

Adaptation Space: Surviving Non-Maskable Failures  

E-Print Network (OSTI)

Some failures cannot be masked by redundancies, because an unanticipated situation occurred, because fault-tolerance measures were not adequate, or because there was a security breach (which is not amenable to replication). Applications that wish to continue to offer some service despite nonmaskable failure must adapt to the loss of resources. When numerous combinations of non-maskable failure modes are considered, the set of possible adaptations becomes complex. This paper presents adaptation spaces, a formalism for navigating among combinations of adaptations. An adaptation space describes a collection of possible adaptations of a software component or system, and provides a uniform way of viewing a group of alternative software adaptations. Adaptation spaces describe the different means for monitoring the conditions that different adaptations depend on, and the particular configurations through which an adaptive application navigate. Our goal is to use adaptation spaces to provide survivable services to applications despite non-maskable failures such as malicious attacks. We present the basic concepts concerning adaptation spaces, with examples. We then present a formal model for reasoning about and selecting alternative adaptations, allowing developers of survivable application to automate their systems adaptive behavior. 1

Crispin Cowan; Lois Delcambre; Anne-francoise Le Meur; Ling Liu; David Maier; Dylan Mcnamee; Michael Miller; Calton Pu; Perry Wagle; Jonathan Walpole

1998-01-01T23:59:59.000Z

266

The Contribution of Radiative Feedbacks to Orbitally Driven Climate Change  

Science Conference Proceedings (OSTI)

Radiative feedbacks influence Earth's climate response to orbital forcing, amplifying some aspects of the response while damping others. To better understand this relationship, the GFDL Climate Model, version 2.1 (CM2.1), is used to perform ...

Michael P. Erb; Anthony J. Broccoli; Amy C. Clement

2013-08-01T23:59:59.000Z

267

Adaptive protection algorithm and system  

Science Conference Proceedings (OSTI)

An adaptive protection algorithm and system for protecting electrical distribution systems traces the flow of power through a distribution system, assigns a value (or rank) to each circuit breaker in the system and then determines the appropriate trip set points based on the assigned rank.

Hedrick, Paul (Pittsburgh, PA); Toms, Helen L. (Irwin, PA); Miller, Roger M. (Mars, PA)

2009-04-28T23:59:59.000Z

268

Adaptive wiener image restoration kernel  

DOE Patents (OSTI)

A method and device for restoration of electro-optical image data using an adaptive Wiener filter begins with constructing imaging system Optical Transfer Function, and the Fourier Transformations of the noise and the image. A spatial representation of the imaged object is restored by spatial convolution of the image using a Wiener restoration kernel.

Yuan, Ding (Henderson, NV)

2007-06-05T23:59:59.000Z

269

Synchrotron Ultraviolet Radiation Facility SURF III ...  

Science Conference Proceedings (OSTI)

... Synchrotron Radiation. What is Synchrotron Radiation? Synchrotron radiation ... known. Properties of Synchrotron Radiation. Schwinger ...

270

Functional Proteomic Pattern Identification under Low Dose Ionizing Radiation  

Science Conference Proceedings (OSTI)

The goal of this study is to explore and to understand the dynamic responses of signaling pathways to low dose ionizing radiation (IR). Low dose radiation (10 cGy or lower) affects several signaling pathways including DNA repair, survival, cell cycle, ... Keywords: low dose radiation, functional proteomics

Young Bun Kim; Jean Gao; Ying Dong; Chin-Rang Yang

2008-11-01T23:59:59.000Z

271

Small satellite radiation budget instrumentation  

Science Conference Proceedings (OSTI)

A major diagnostic in understanding the response of the Earth`s climate to natural or anthropogenic changes is the radiative balance at the top of the atmosphere. Two classes of measurements may be undertaken: (1) a monitoring of the radiation balance over decade-long long time-scales, and (2) measurements designed to provide a sufficiently complete data set to validate or improve models. This paper discusses some of the important ingredients in obtaining such data, and presents a description of some candidate instrumentation for use on a small satellite. 23 refs.

Weber, P.G.

1992-05-01T23:59:59.000Z

272

Small satellite radiation budget instrumentation  

Science Conference Proceedings (OSTI)

A major diagnostic in understanding the response of the Earth's climate to natural or anthropogenic changes is the radiative balance at the top of the atmosphere. Two classes of measurements may be undertaken: (1) a monitoring of the radiation balance over decade-long long time-scales, and (2) measurements designed to provide a sufficiently complete data set to validate or improve models. This paper discusses some of the important ingredients in obtaining such data, and presents a description of some candidate instrumentation for use on a small satellite. 23 refs.

Weber, P.G.

1992-01-01T23:59:59.000Z

273

Hardware implementation of wireless bit rate adaptation  

E-Print Network (OSTI)

This thesis presents a hardware implementation of the SoftRate bit-rate adaptation protocol. SoftRate is a new bit-rate adaptation protocol, which uses per-bit confidence hints generated by the convolutional decoder to ...

Gross, Samuel A

2010-01-01T23:59:59.000Z

274

An extensible monitoring and adaptation framework  

Science Conference Proceedings (OSTI)

Several techniques have been defined for the monitoring and adaptation of applications. However, such techniques usually work in isolation and cannot be easily integrated to tackle complex monitoring and adaptation scenarios. Furthermore, applications ...

Razvan Popescu; Athanasios Staikopoulos; Siobhn Clarke

2009-11-01T23:59:59.000Z

275

Adaptive control of Unmanned Aerial Systems  

E-Print Network (OSTI)

Adaptive control is considered to be one of the key enabling technologies for future high-performance, safety-critical systems such as air-breathing hypersonic vehicles. Adaptive flight control systems offer improved ...

Dydek, Zachary Thompson

2010-01-01T23:59:59.000Z

276

Low Dose Radiation Research Program: About  

NLE Websites -- All DOE Office Websites (Extended Search)

About About Background. Extensive research on the health effects of radiation using standard epidemiological and toxicological approaches has been done for decades to characterize responses of populations and individuals to high radiation doses, and to set exposure standards to protect both the public and the workforce. These standards were set using models that extrapolated from the cancers observed following exposure to high doses of radiation to predicted, but not measurable, changes in cancer frequency at low radiation doses. The use of models was necessary because of our inability to detect changes in cancer incidence following low doses of radiation. Historically, the predominant approach has been the Linear-no-Threshold model (see Wikipedia entry) and collective dose concept that assumes each unit of radiation, no

277

Method and devices for performing stereotactic microbeam radiation therapy  

DOE Patents (OSTI)

A radiation delivery system generally includes either a synchrotron source or a support frame and a plurality of microbeam delivery devices supported on the support frame, both to deliver a beam in a hemispherical arrangement. Each of the microbeam delivery devices or synchrotron irradiation ports is adapted to deliver at least one microbeam of radiation along a microbeam delivery axis, wherein the microbeam delivery axes of the plurality of microbeam delivery devices cross within a common target volume.

Dilmanian, F. Avraham (Yaphank, NY)

2010-01-05T23:59:59.000Z

278

Space Radiation Dosimetry: an Optically Stimulated Luminescence Radiation Detector for Low-earth Orbit.  

E-Print Network (OSTI)

??The purpose of this study was to investigate Alsub#2/sub#Osub#3/sub#:C as a potential optically stimulated luminescence (OSL) radiation detector for Low-Earth Orbit. The OSL response of (more)

Gaza, Ramona

2004-01-01T23:59:59.000Z

279

Radiation Safety  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Brotherhood of Locomotive Brotherhood of Locomotive Engineers & Trainmen Scott Palmer BLET Radiation Safety Officer New Hire Training New Hire study topics * GCOR * ABTH * SSI * Employee Safety * HazMat * Railroad terminology * OJT * 15-week class * Final test Hazardous Materials * Initial new-hire training * Required by OSHA * No specified class length * Open book test * Triennial module Locomotive Engineer Training A little bit older...a little bit wiser... * Typically 2-4 years' seniority * Pass-or-get-fired promotion * Intensive program * Perpetually tested to a higher standard * 20 Weeks of training * 15 of that is OJT * General Code of Operating Rules * Air Brake & Train Handling * System Special Instructions * Safety Instructions * Federal Regulations * Locomotive Simulators * Test Ride * Pass test with 90% Engineer Recertification

280

RADIATION COUNTER  

DOE Patents (OSTI)

This patent relates to a radiation counter, and more particularly, to a scintillation counter having high uniform sensitivity over a wide area and capable of measuring alpha, beta, and gamma contamination over wide energy ranges, for use in quickly checking the contami-nation of personnel. Several photomultiplier tubes are disposed in parallel relationship with a light tight housing behind a wall of scintillation material. Mounted within the housing with the photomultipliers are circuit means for producing an audible sound for each pulse detected, and a range selector developing a voltage proportional to the repetition rate of the detected pulses and automatically altering its time constant when the voltage reaches a predetermined value, so that manual range adjustment of associated metering means is not required.

Goldsworthy, W.W.

1958-02-01T23:59:59.000Z

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

RADIATION DOSIMETER  

DOE Patents (OSTI)

An improvement was made in the determination of amounts of ionizing radiation, particularly low-energy beta particles of less than 1000 rad total dose by means of fluid-phase dosimeter employing a stabilized-- sensitized ferrous-ferric colorimetric system in a sulphuric acid medium. The improvement in the dosimeter consists of adding to the ferrous-ferric system in concentrations of 10/sub -2/ to 10/sup -4/M an organic compound having one or more carboxylic or equivalent groups, such compounds being capable of chelating or complexing the iron ions in the solution. Suitable sensitizing and stabilizing agents are benzoic, phthalic, salicylic, malonic, lactic, maleic, oxalic, citric, succinic, phenolic tartaric, acetic, and adipic acid, as well as other compounds which are added to the solution alone or in certain combinations. As in conventional fluid-phase dosimeters, the absorbed dosage is correlated with a corresponding change in optical density at particular wavelengths of the solution.

Balkwell, W.R. Jr.; Adams, G.D. Jr.

1960-05-10T23:59:59.000Z

282

FAQS Qualification Card - Radiation Protection | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Radiation Protection Radiation Protection FAQS Qualification Card - Radiation Protection A key element for the Department's Technical Qualification Programs is a set of common Functional Area Qualification Standards (FAQS) and associated Job Task Analyses (JTA). These standards are developed for various functional areas of responsibility in the Department, including oversight of safety management programs identified as hazard controls in Documented Safety Analyses (DSA). For each functional area, the FAQS identify the minimum technical competencies and supporting knowledge and skills for a typical qualified individual working in the area. FAQC-RadiationProtection.docx Description Radiation Protection Qualification Card More Documents & Publications FAQS Gap Analysis Qualification Card - Radiation Protection

283

Boundedness of adaptive nets is decidable  

Science Conference Proceedings (OSTI)

Boundedness is a relevant property for adaptive systems: creation, composition and destruction of components at runtime introduce different infiniteness dimensions. In this paper we show the decidability of the boundedness for adaptive nets, a subclass ... Keywords: Adaptive nets, Boundedness, Decidability, Theory of computation

Olivia Oanea

2011-08-01T23:59:59.000Z

284

Adaptive Techniques for Homebased Software DSMs #  

E-Print Network (OSTI)

Adaptive Techniques for Home­based Software DSMs # Lauro Whately 1 , Raquel Pinto 1 , Muralidharan and evaluates Home­based Adaptive Protocol (HAP), a software distributed shared­memory system. HAP performs two with the adaptive system. Keywords---Software Distributed Shared Memory, Home­basedLazy Release Consistency, Home­based

Bianchini, Ricardo

285

A platform for developing adaptable multicore applications  

Science Conference Proceedings (OSTI)

Computer systems are resource constrained. Application adaptation is a useful way to optimize system resource usage while satisfying the application performance constraints. Previous application adaptation efforts, however, were ad-hoc, time-consuming, ... Keywords: application adaptation, frequency scaling, multicore, parallelization, run-time systems

Dan Fay; Li Shang; Dirk Grunwald

2009-10-01T23:59:59.000Z

286

Presented by Adaptive Hybrid Mesh Refinement for  

E-Print Network (OSTI)

meters. · Orography plays an important role in determining the strength and location of the atmospheric on orographic field data Hybrid adapted geodesic mesh based on orographic field data Structured adapted spherical mesh based on orographic field data #12;7 Khamayseh_ITAPS_SC07 h-Adaptive hybrid mesh generation

287

Enhancing adaptability of distributed groupware applications  

Science Conference Proceedings (OSTI)

Distributed Groupware applications must be designed to cope with an increasingly diverse set of operational conditions. The available network bandwidth and latency, the network connectivity, the number of users, the type of devices, the system load, ... Keywords: adaptability, adaptive, adaptive layer, context awareness, groupware, mobile devices

Tebalo Tsoaeli; Judith Bishop

2005-07-01T23:59:59.000Z

288

Lanthanum halide nanoparticle scintillators for nuclear radiation detection  

SciTech Connect

Nanoparticles with sizes <10 nm were fabricated and characterized for their nanocomposite radiation detector properties. This work investigated the properties of several nanostructured radiation scintillators, in order to determine the viability of using scintillators employing nanostructured lanthanum trifluoride. Preliminary results of this investigation are consistent with the idea that these materials have an intrinsic response to nuclear radiation that may be correlated to the energy of the incident radiation.

Guss, Paul; Guise, Ronald [Remote Sensing Laboratory, P.O. Box 98521, M/S RSL-48, Las Vegas, Nevada 89193 (United States); Yuan Ding [National Security Technologies, LLC, Los Alamos Operations, P.O. Box 809, M/S LAO/C320, Los Alamos, New Mexico 87544 (United States); Mukhopadhyay, Sanjoy [Remote Sensing Laboratory-Andrews, Building 1783, Arnold Avenue Andrews AFB, Maryland 20762 (United States); O'Brien, Robert; Lowe, Daniel [University of Nevada, Las Vegas, 4505 S. Maryland Parkway, Las Vegas, Nevada 89154 (United States); Kang Zhitao; Menkara, Hisham [Georgia Tech Research Institute, 925 Dalney St., Atlanta, Georgia 30332 (United States); Nagarkar, Vivek V. [RMD, Inc., 44 Hunt Street, Watertown, Massachusetts 02472 (United States)

2013-02-14T23:59:59.000Z

289

Adapted Physical Education Handbook Acknowledgements  

E-Print Network (OSTI)

It would be very difficult to individually acknowledge all the contributors to this handbook. As I visited colleges around the state, I was always welcomed with open arms by the adapted physical education faculty and staff. Their willingness to take time from their very busy schedules to show me their adapted physical education programs, to fill-out and return a six-page survey, and to attend the regional workshops was most appreciated. This handbook would not have been possible without their contributions and daily efforts to improve programs and services for students with disabilities. I would like to acknowledge Scott Hamilton, Statewide DSP&S Coordinator for the California Community Colleges, for his thoughtful support and guidance throughout this project. I would also like to express my thanks to Noel Roberts, Statewide DSP&S Analyst, for her timely administrative assistance in making the handbook possible. I would especially like to acknowledge the professionalism and dedication of the Adapted Physical Education Handbook Project Task Group. The handbook would never have achieved the same impact and magnitude without the knowledge, experience, and expertise that Kathy Bell, Mark Clements, Jon James, Chuck Keller, Mark Lipe, Mary Martin, and Lee Miller Parks brought to this

Jim Haynes

2002-01-01T23:59:59.000Z

290

Gamma Radiation & X-Rays  

NLE Websites -- All DOE Office Websites (Extended Search)

Gamma Radiation and X-Rays 1. Gamma radiation and X-rays are electromagnetic radiation like visible light, radio waves, and ultraviolet light. These electromagnetic radiations...

291

Demand Response for Ancillary Services  

Science Conference Proceedings (OSTI)

Many demand response resources are technically capable of providing ancillary services. In some cases, they can provide superior response to generators, as the curtailment of load is typically much faster than ramping thermal and hydropower plants. Analysis and quantification of demand response resources providing ancillary services is necessary to understand the resources economic value and impact on the power system. Methodologies used to study grid integration of variable generation can be adapted to the study of demand response. In the present work, we describe and illustrate a methodology to construct detailed temporal and spatial representations of the demand response resource and to examine how to incorporate those resources into power system models. In addition, the paper outlines ways to evaluate barriers to implementation. We demonstrate how the combination of these three analyses can be used to translate the technical potential for demand response providing ancillary services into a realizable potential.

Alkadi, Nasr E [ORNL; Starke, Michael R [ORNL

2013-01-01T23:59:59.000Z

292

Maximizing Tumor Immunity With Fractionated Radiation  

Science Conference Proceedings (OSTI)

Purpose: Technologic advances have led to increased clinical use of higher-sized fractions of radiation dose and higher total doses. How these modify the pathways involved in tumor cell death, normal tissue response, and signaling to the immune system has been inadequately explored. Here we ask how radiation dose and fraction size affect antitumor immunity, the suppression thereof, and how this might relate to tumor control. Methods and Materials: Mice bearing B16-OVA murine melanoma were treated with up to 15 Gy radiation given in various-size fractions, and tumor growth followed. The tumor-specific immune response in the spleen was assessed by interferon-{gamma} enzyme-linked immunospot (ELISPOT) assay with ovalbumin (OVA) as the surrogate tumor antigen and the contribution of regulatory T cells (Tregs) determined by the proportion of CD4{sup +}CD25{sup hi}Foxp3{sup +} T cells. Results: After single doses, tumor control increased with the size of radiation dose, as did the number of tumor-reactive T cells. This was offset at the highest dose by an increase in Treg representation. Fractionated treatment with medium-size radiation doses of 7.5 Gy/fraction gave the best tumor control and tumor immunity while maintaining low Treg numbers. Conclusions: Radiation can be an immune adjuvant, but the response varies with the size of dose per fraction. The ultimate challenge is to optimally integrate cancer immunotherapy into radiation therapy.

Schaue, Doerthe, E-mail: dschaue@mednet.ucla.edu [Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA (United States); Ratikan, Josephine A.; Iwamoto, Keisuke S.; McBride, William H. [Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA (United States)

2012-07-15T23:59:59.000Z

293

DETECTORS FOR RADIATION DOSIMETRY  

E-Print Network (OSTI)

2) W. J. Price, "Nuclear Radiation Detection" (2nd ed. , Newand R. J. Berry, "Manual on Radiation Dosimetry" (New York:4) G. F. Knoll, "Radiation Detection and Measurement" (New

Perez-Mendez, V.

2010-01-01T23:59:59.000Z

294

Demand Response  

NLE Websites -- All DOE Office Websites (Extended Search)

Peak load diagram Demand Response Demand Response (DR) is a set of time-dependent activities that reduce or shift electricity use to improve electric grid reliability, manage...

295

Demand Response  

NLE Websites -- All DOE Office Websites (Extended Search)

Peak load diagram Demand Response Demand response (DR) is a set of time-dependent activities that reduce or shift electricity use to improve electric grid reliability, manage...

296

Low Dose Radiation Research Program: Genetic Factors Affecting  

NLE Websites -- All DOE Office Websites (Extended Search)

Affecting Susceptibility to Low-Dose Radiation Affecting Susceptibility to Low-Dose Radiation William F. Morgan Pacific Northwest National Laboratory Why This Project The short-term effects of high doses of ionizing radiation on cellular responses are relatively well understood. Less clear are the long-term consequences of exposure to low dose/low dose-rate radiation and the effects of radiation exposure on the progeny of surviving cells. If a cell survives radiation, it is generally thought to have repaired all the radiation-induced insults and be capable of a "normal healthy life". At a certain frequency, however, we have found that some cells surviving radiation grow normally, but will rearrange their genetic material during time in culture. We call this radiation-induced genomic instability. Many

297

Low Dose Radiation Research Program: Universities  

NLE Websites -- All DOE Office Websites (Extended Search)

Universities Universities | Duke University | Loma Linda University | Northwestern University | University of Chicago | University of California Davis | Northwestern University University of Chicago University of California Davis Effects of Low Dose Irradiation on NF-κB Signaling Networks and Mitochondria Principal Investigator: Dr. Gayle Woloschak DOE Low Dose Research Program Projects Low dose-low dose rate irradiation leads to long term changes in numbers of mitochondria and mitochondrial genomes - Principal Investigator: Gayle Woloschak, Professor, Department of Radiation Oncology, Northwestern University, Chicago, IL, USA NF-κB-mediated pro-survival network in low dose radiation-induced adaptive protection - Principal Investigator: Jian Jian Li, Professor, Department of Radiation Oncology, University of California Davis, Davis,

298

Adaptive Comfort Model: Simulations & Future Directions  

NLE Websites -- All DOE Office Websites (Extended Search)

Adaptive Comfort Model: Simulations & Future Directions Adaptive Comfort Model: Simulations & Future Directions Speaker(s): Richard de Dear Date: February 4, 2011 - 12:00pm Location: 90-4133 Seminar Host/Point of Contact: Philip Haves The last 20 years of thermal comfort have witnessed a shift away from the "static" approach (exemplified by the PMV/PPD model) towards the adaptive approach (exemplified by the adaptive models in ASHRAE's Standard 55 (2004, 2010) and the European Union's counterpart standard, EN15251 (2007). - the basis and derivation of the adaptive comfort model - adaptive comfort standards (ASHRAE 55 and EN15251) - new developments and directions (reporting back from the January 2011 ASHRAE Meeting of SSPC-55 in Las Vegas) - environmental variables other than dry bulb, in the adaptive model

299

Solar radiation resource assessment  

DOE Green Energy (OSTI)

The bulletin discusses the following: introduction; Why is solar radiation resource assessment important Understanding the basics; the solar radiation resource assessment project; and future activities.

Not Available

1990-11-01T23:59:59.000Z

300

Courses on Synchrotron Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Synchrotron Radiation The following is an incomplete list of courses on Synchrotron Radiation. For additional courses, check lightsources.org. XAFS School The APS XAFS School...

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Radiation Physics Events  

Science Conference Proceedings (OSTI)

NIST Home > Radiation Physics Events. Radiation Physics Events. (showing 1 - 3 of 3). CIRMS 2012 Start Date: 10/22/2012 ...

2011-12-01T23:59:59.000Z

302

Bayesian Radiation Source Localization  

Science Conference Proceedings (OSTI)

Technical Paper / Special Issue on the 16th Biennial Topical Meeting of the Radiation Protection and Shielding Division / Radiation Measurements and General Instrumentation

Kenneth D. Jarman; Erin A. Miller; Richard S. Wittman; Christopher J. Gesh

303

Latest Research, Response to Fukushima, Integrating Low Dose...  

NLE Websites -- All DOE Office Websites (Extended Search)

Latest Research, Response to Fukushima, Integrating Low Dose into Policy-All Featured at Annual Investigators' Workshop The 10th DOE Low Dose Radiation Research Program...

304

Mechanisms Underlying Cellular Responses to Low Dose/Low LET...  

NLE Websites -- All DOE Office Websites (Extended Search)

expression, chromosomal and apoptotic analysis suggest a model for strain specific radiation response; normal DNA damage recognition and repair leading to cell death and...

305

Modular Systems Biology applied to TGFbeta and DNA Damage Response...  

NLE Websites -- All DOE Office Websites (Extended Search)

Modular Systems Biology applied to TGFbeta and DNA Damage Response Signaling following Low Dose Radiation Francis Cucinotta NASA Johnson Space Center Abstract Modular systems...

306

Microscreen radiation shield for thermoelectric generator  

DOE Patents (OSTI)

The present invention provides a microscreen radiation shield which reduces radiative heat losses in thermoelectric generators such as sodium heat engines without reducing the efficiency of operation of such devices. The radiation shield is adapted to be interposed between a reaction zone and a means for condensing an alkali metal vapor in a thermoelectric generator for converting heat energy directly to electrical energy. The radiation shield acts to reflect infrared radiation emanating from the reaction zone back toward the reaction zone while permitting the passage of the alkali metal vapor to the condensing means. The radiation shield includes a woven wire mesh screen or a metal foil having a plurality of orifices formed therein. The orifices in the foil and the spacing between the wires in the mesh is such that radiant heat is reflected back toward the reaction zone in the interior of the generator, while the much smaller diameter alkali metal atoms such as sodium pass directly through the orifices or along the metal surfaces of the shield and through the orifices with little or no impedance.

Hunt, Thomas K. (Ann Arbor, MI); Novak, Robert F. (Farmington Hills, MI); McBride, James R. (Ypsilanti, MI)

1990-01-01T23:59:59.000Z

307

Uganda-National Adaptation Programme of Action | Open Energy...  

Open Energy Info (EERE)

Adaptation Programme of Action AgencyCompany Organization United Nations Environment Programme, Global Environment Facility, Environmental Alert Topics Adaptation,...

308

Tanzania-National Adaptation Programme of Action | Open Energy...  

Open Energy Info (EERE)

Adaptation Programme of Action AgencyCompany Organization United Nations Environment Programme, Global Environment Facility Topics Adaptation, Background analysis...

309

Low Dose Radiation Program: Radiation Biology and the Radiation Research  

NLE Websites -- All DOE Office Websites (Extended Search)

Biology and the Radiation Research Program Biology and the Radiation Research Program The Department of Energy (DOE) and its predecessor organizations, Energy Research and Development Agency (ERDA) and Atomic Energy Commission (AEC), always have been concerned about the health effects of ionizing radiation. Extensive research has been conducted under their sponsorship at all levels of biological organization from molecules to man. Over the past 60 years, studies using every type of radiation source have included exposure to both external radiation sources and to internally deposited radioactive materials. These exposures used different dose patterns and distributions delivered over a wide range of experimental times. This extensive research provided the basis for the new Low Dose Radiation Research Program, linking

310

NIST MIRF - Accelerator Radiation Physics  

Science Conference Proceedings (OSTI)

Accelerator Radiation Physics. Medium-energy accelerators are under investigation for production of channeling radiation ...

311

NIST Synchrotron radiation in SSD  

Science Conference Proceedings (OSTI)

Synchrotron radiation in the Sensor Science Division. ... Synchrotron Radiation-Based Calibrations for Space Weather Prediction. ...

2011-10-18T23:59:59.000Z

312

Specifying and Adapting Object Behavior during System Evolution  

E-Print Network (OSTI)

Object-Oriented software engineering must address new issues during system evolution, namely the effects of class evolution on existing class methods. A Class Dictionary Graph describes the class structure and relationships of a given domain. A Propagation Pattern defines object behavior by describing responsibilities among a group of collaborating classes. The behavior described in a Propagation Pattern is mapped onto the class structure defined in a Class Dictionary Graph, and the appropriate C++ code is generated. Class structures evolve in many ways. This paper details the effects of class evolution on the object behavior defined in existing Propagation Patterns, and describes the requirements for adapting Propagation Patterns during class evolution, as compared to the efforts of maintaining C++ code. Keywords: System Evolution, Adaptive Software Development, Object-Oriented Software Engineering. 1 Introduction Evolution of business processes and organization is a major force to ...

Linda Keszenheimer

1993-01-01T23:59:59.000Z

313

Radiation Detection Instruments  

Science Conference Proceedings (OSTI)

Directory of Accredited Laboratories. Radiation Detection Instruments. In 2005, the Department of Homeland Security requested ...

2013-09-06T23:59:59.000Z

314

Radiative Heat Transfer between Neighboring Particles  

E-Print Network (OSTI)

The near-field interaction between two neighboring particles is known to produce enhanced radiative heat transfer. We advance in the understanding of this phenomenon by including the full electromagnetic particle response, heat exchange with the environment, and important radiative corrections both in the distance dependence of the fields and in the particle absorption coefficients. We find that crossed terms of electric and magnetic interactions dominate the transfer rate between gold and SiC particles, whereas radiative corrections reduce it by several orders of magnitude even at small separations. Radiation away from the dimer can be strongly suppressed or enhanced at low and high temperatures, respectively. These effects must be taken into account for an accurate description of radiative heat transfer in nanostructured environments.

Alejandro Manjavacas; F. Javier Garcia de Abajo

2012-01-26T23:59:59.000Z

315

Management Responsibilities  

NLE Websites -- All DOE Office Websites (Extended Search)

Management Responsibilities Management Responsibilities Depleted UF6 Management Responsibilities DOE has responsibility for safe and efficient management of approximately 700,000 metric tons of depleted UF6. Organizational Responsibilities In the United States, the U.S. Department of Energy is responsible for managing all the depleted uranium that has been generated by the government and has been declared surplus to national defense needs. In addition, as a result of two memoranda of agreement that have been signed between the DOE and USEC, the DOE has assumed management responsibility for approximately 145,000 metric tons of depleted UF6 that has been or will be generated by USEC. Any additional depleted UF6 that USEC generates will be USEC's responsibility to manage. DOE Management Responsibility

316

radiation.p65  

Office of Legacy Management (LM)

5 5 United States Department of Energy This fact sheet explains the potential health hazards associated with the radioactive decay of uranium and other radioactive elements found in ore and mill tailings. Potential Health Hazards of Radiation Man-made sources of radiation, most notably from medical uses and consumer products, contribute to the remaining radiation dose that individuals receive. A few household products, including smoke detectors, micro- wave ovens, and color televisions, emit small amounts of radiation. For most people, the benefits from using such products far outweigh the radiation risks. Radiation Dose Radiation is measured in various units. Individuals who have been exposed to radiation have received a radiation dose. Radiation dose to people is expressed in

317

Radiation Emergency Assistance Center / Training Site | National Nuclear  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation Emergency Assistance Center / Training Site | National Nuclear Radiation Emergency Assistance Center / Training Site | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Radiation Emergency Assistance Center / Training Site Home > About Us > Our Programs > Emergency Response > Responding to Emergencies > Consequence Management > Radiation Emergency Assistance

318

Has radiation protection become a health hazard?  

SciTech Connect

Scientists and engineers have a responsibility to speak out when their findings and recommendations lead to public harm. This can happen in several ways. One is when the media misinterpret or sensationalize a scientific fact misleading the public and creating unwarranted fear. Another is when regulations or public policy decision are purportedly based on scientific data but are, in fact, scientifically invalid. Fear of radiation has been far more detrimental to health than radiation itself. The author knows of no deaths to the public from accidental release of radiation, but the consequences of fear have been deadly.

Rockwell, T. [MPR Associates, Inc., Washington, DC (United States)

1996-12-31T23:59:59.000Z

319

Radiation Field Control Manual  

Science Conference Proceedings (OSTI)

The EPRI Radiation Management Program is dedicated to reducing nuclear power plant worker personnel exposure by developing practices and technologies to increase the radiation protection of the worker, and to implement methods to reduce radiation fields. The nuclear power industry has recently implemented the RP2020 Initiative to promote positive radiation protection trends. Control of radiation fields is crucial to one of the initiative goals of reducing exposure. This manual provides the current state ...

2004-12-16T23:59:59.000Z

320

Towards Process Models for Disaster Response Dirk Fahland1  

E-Print Network (OSTI)

Towards Process Models for Disaster Response Dirk Fahland1 and Heiko Woith2 1 Humboldt capture process execution and adaptation. Based on experiences from actual disaster response set- tings, scenarios, Petri nets, disaster response 1 Introduction The fairly general notion of a process

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

An Update on SURFRADThe GCOS Surface Radiation Budget Network for the Continental United States  

Science Conference Proceedings (OSTI)

The Surface Radiation budget (SURFRAD) network was developed for the United States in the middle 1990s in response to a growing need for more sophisticated in situ surface radiation measurements to support satellite system validation; numerical ...

John A. Augustine; Gary B. Hodges; Christopher R. Cornwall; Joseph J. Michalsky; Carlos I. Medina

2005-10-01T23:59:59.000Z

322

Feedbacks between Eddy Heat Fluxes and Radiative Heating in an Energy-Balance Model  

Science Conference Proceedings (OSTI)

The response of midlatitude temperature structure to changes in radiative forcing is examined in an analytical energy-balance model that includes parameterized eddy heat fluxes and linear radiative heating. The characteristics of heat-...

Lee E. Branscome; Enda O'Brien

1988-02-01T23:59:59.000Z

323

Optimization Online - An adaptive accelerated proximal gradient ...  

E-Print Network (OSTI)

Apr 5, 2013 ... In case the strong convexity parameter is unknown, we also develop an adaptive scheme that can automatically estimate it on the fly, at the cost...

324

Assessing Climate Change Impacts, Vulnerability and Adaptation...  

Open Energy Info (EERE)

The Case of Pantabangan-Carranglan Watershed Jump to: navigation, search Name Assessing Climate Change Impacts, Vulnerability and Adaptation: The Case of Pantabangan-Carranglan...

325

Adaptive computations on conforming quadtree meshes  

E-Print Network (OSTI)

adaptive re?nement for B-spline ?nite element, Int. J.enrichment [6,7] as well as B-splines [8]. These methods

Tabarraei, A; Sukumar, N

2005-01-01T23:59:59.000Z

326

Does an accelerated electron radiate Unruh radiation?  

E-Print Network (OSTI)

An accelerated particle sees the Minkowski vacuum as thermally excited, and the particle moves stochastically due to an interaction with the thermal bath. This interaction fluctuates the particle's transverse momenta like the Brownian motion in a heat bath. Because of this fluctuating motion, it has been discussed that the accelerated charged particle emits extra radiation (the Unruh radiation) in addition to the classical Larmor radiation, and experiments are under planning to detect such radiation by using ultrahigh intensity lasers constructed in near future. There are, however, counterarguments that the radiation is canceled by an interference effect between the vacuum fluctuation and the fluctuating motion. In fact, in the case of an internal detector where the Heisenberg equation of motion can be solved exactly, there is no additional radiation after the thermalization is completed. In this paper, we revisit the issue in the case of an accelerated charged particle in the scalar QED. We first prove the e...

Iso, Satoshi; Zhang, Sen

2010-01-01T23:59:59.000Z

327

Low Dose Radiation Research Program: Original Research Program Plan  

NLE Websites -- All DOE Office Websites (Extended Search)

Original Research Program Plan Original Research Program Plan Biological Effects of Low Dose and Dose Rate Radiation Prepared for the Office of Biological and Environmental Research by The Low Dose Radiation Research Program Plan Subcommittee of the Biological and Environmental Research Advisory Committee. II. Table of Contents Face Page Table of Contents Executive Summary Introduction Program Outline Low Dose Radiation vs. Endogenous Oxidative Damage - The Same or Different? Key Question Description Decision Making Value Recommendations and Costs Understanding Biological Responses to Radiation And Endogenous Damage Key Question Description Decision Making Value Recommendations and Costs Thresholds for Low Dose Radiation - Fact or Fiction? Key Question Description Decision Making Value Recommendations and Costs

328

Policy-driven distributed and collaborative demand response in multi-domain commercial buildings  

Science Conference Proceedings (OSTI)

Enabling a sophisticated Demand Response (DR) framework, whereby individual consumers adapt their electricity consumption in response to price variations, is a major objective of the emerging Smart Grid. We first point out why the current model, of EMS-based ...

Archan Misra; Henning Schulzrinne

2010-04-01T23:59:59.000Z

329

Tailor Made: Adapting Psychotherapeutic Interventions  

E-Print Network (OSTI)

With increased diversity and globalization, there is increased emphasis on awareness of cultural influences on functioning and in fostering cultural competence. This is particularly important in the context of intervention planning and acceptability. The standard approach is through didactic coursework; however the extent to which the content of the courses is universal and includes relevance for intervention is unknown. The purpose of this content analysis was to determine whether or not cultural competence is addressed in psychotherapeutic intervention coursework. Direct intervention syllabi from APA accredited school psychology doctoral programs were analyzed. Findings suggest that cultural competence is minimally addressed in intervention courses. Similarly, the mechanisms for culturally adapting interventions are rarely addressed. Findings further suggest that when addressing cultural competence intervention courses focus on applying knowledge to the delivery of services. Understanding the content of current curricula may provide trainers with information to aid in designing their curriculum so that pre service school psychologists may matriculate with a broader basic therapy skill set.

Henry-Smith, Latanya Sherone

2013-08-01T23:59:59.000Z

330

Downhole tool adapted for telemetry  

DOE Patents (OSTI)

A cycleable downhole tool such as a Jar, a hydraulic hammer, and a shock absorber adapted for telemetry. This invention applies to other tools where the active components of the tool are displaced when the tool is rotationally or translationally cycled. The invention consists of inductive or contact transmission rings that are connected by an extensible conductor. The extensible conductor permits the transmission of the signal before, after, and during the cycling of the tool. The signal may be continuous or intermittent during cycling. The invention also applies to downhole tools that do not cycle, but in operation are under such stress that an extensible conductor is beneficial. The extensible conductor may also consist of an extensible portion and a fixed portion. The extensible conductor also features clamps that maintain the conductor under stresses greater than that seen by the tool, and seals that are capable of protecting against downhole pressure and contamination.

Hall, David R. (Provo, UT); Fox, Joe (Provo, UT)

2010-12-14T23:59:59.000Z

331

A Power and Resolution Adaptive  

E-Print Network (OSTI)

A new power and resolution adaptive flash ADC, named PRA-ADC, is proposed. The PRA-ADC enables exponential power reduction with linear resolution reduction. Unused parallel voltage comparators are switched to standby mode. The voltage comparators consume only the leakage power during the standby mode. The PRA-ADC, capable of operating at 5-bit, 6-bit, 7-bit, and 8-bit precision, dissipates 69 mW at 5-bit and 435 mW at 8-bit. The PRA-ADC was designed and simulated with 0.18 m CMOS technology. The PRA-ADC design is applicable to RF portable communication devices, allowing tighter management of power and e#ciency.

Flash Analog-To-Digital Converter; Jincheol Yoo; Daegyu Lee; Kyusun Choi; Jongsoo Kim

2002-01-01T23:59:59.000Z

332

Transcending the Adaptation/Mitigation Climate Change Science Policy Debate: Unmasking Assumptions about Adaptation and Resilience  

Science Conference Proceedings (OSTI)

The two principal policy approaches to global climate change include mitigation and adaption. In recent years, the interest in adaptation and resilience has increased significantly in part because anthropogenic climate change appears unavoidable ...

Tori L. Jennings

2011-10-01T23:59:59.000Z

333

UTC Response  

Science Conference Proceedings (OSTI)

... Security Incident response teams, Cyber Security Incident handling ... is the mandatory standards for nuclear power reactor licensees, 10 CFR ...

2013-04-10T23:59:59.000Z

334

radiation.cdr  

Office of Legacy Management (LM)

Radiation-It's a Fact of Life Radiation-It's a Fact of Life It has been with us since the beginning of time. Everyone who has ever walked on this planet has been exposed to radiation. For the most part, nature is the largest source of exposure. It's in the air we breathe, the ground we walk on, and even the food we eat. The radiation we receive from all natural and some man-made sources is called "background radiation." The millirem (mrem) is a unit used for measuring radiation received by a person. The total average background for radiation received by people living in the United States is 360 millirem per year (mrem/yr), of which 300 mrem/yr is from natural sources, and 60 mrem/yr is man-made. Cosmic Radiation from the sun and stars Internal Radiation from naturally radioactive

335

Low Dose Radiation Program: Links - General Radiation Information  

NLE Websites -- All DOE Office Websites (Extended Search)

General Radiation Information Answers to Questions about Radiation Dose Ranges Charts - tables showing radiation dose ranges from radio diagnostics to cancer radiotherapy....

336

Low Dose Radiation Program: Links - Websites about Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Websites About Radiation The ABC's of Nuclear Science A Teacher's Guide To The Nuclear Science Wall Chart Answers to Questions about Radiation and You Background Radiation:...

337

Plutonium radiation surrogate  

DOE Patents (OSTI)

A self-contained source of gamma-ray and neutron radiation suitable for use as a radiation surrogate for weapons-grade plutonium is described. The source generates a radiation spectrum similar to that of weapons-grade plutonium at 5% energy resolution between 59 and 2614 keV, but contains no special nuclear material and emits little .alpha.-particle radiation. The weapons-grade plutonium radiation surrogate also emits neutrons having fluxes commensurate with the gamma-radiation intensities employed.

Frank, Michael I. (Dublin, CA)

2010-02-02T23:59:59.000Z

338

Adaptive management: a paradigm for remediation of public facilities  

SciTech Connect

Public facility restoration planning traditionally focused on response to natural disasters and hazardous materials accidental releases. These plans now need to integrate response to terrorist actions. Therefore, plans must address a wide range of potential vulnerabilities. Similar types of broad remediation planning are needed for restoration of waste and hazardous material handling areas and facilities. There are strong similarities in damage results and remediation activities between unintentional and terrorist actions; however, the uncertainties associated with terrorist actions result in a re-evaluation of approaches to planning. Restoration of public facilities following a release of a hazardous material is inherently far more complex than in confined industrial settings and has many unique technical, economic, social, and political challenges. Therefore, they arguably involve a superset of drivers, concerns and public agencies compared to other restoration efforts. This superset of conditions increases complexity of interactions, reduces our knowledge of the initial conditions, and even condenses the timeline for restoration response. Therefore, evaluations of alternative restoration management approaches developed for responding to terrorist actions provide useful knowledge for large, complex waste management projects. Whereas present planning documents have substantial linearity in their organization, the 'adaptive management' paradigm provides a constructive parallel operations paradigm for restoration of facilities that anticipates and plans for uncertainty, multiple/simUltaneous public agency actions, and stakeholder participation. Adaptive management grew out of the need to manage and restore natural resources in highly complex and changing environments with limited knowledge about causal relationships and responses to restoration actions. Similarities between natural resource management and restoration of a facility and surrounding area(s) after a disruptive event suggest numerous advantages over preset linearly-structured plans by incorporating the flexibility and overlap of processes inherent in effective facility restoration. We discuss three restoration case studies (e.g., the Hart Senate Office Building anthrax restoration, Rocky Flats actinide remediation, and hurricane destruction restoration), that implement aspects of adaptive management but not a formal approach. We propose that more formal adoption of adaptive management principles could be a basis for more flexible standards to improve site-specific remediation plans under conditions of high uncertainty.

Janecky, David R [Los Alamos National Laboratory; Whicker, Jeffrey J [Los Alamos National Laboratory; Doerr, Ted B [NON LANL

2009-01-01T23:59:59.000Z

339

Adaptive mesh generation for curved domains  

Science Conference Proceedings (OSTI)

This paper considers the technologies needed to support the creation of adaptively constructed meshes for general curved three-dimensional domains and outlines one set of solutions for providing them. A brief review of an effective way to integrate mesh ... Keywords: adaptive meshes, anisotropic meshes, curved meshes

Mark S. Shephard; Joseph E. Flaherty; Kenneth E. Jansen; Xiangrong Li; Xiaojuan Luo; Nicolas Chevaugeon; Jean-Franois Remacle; Mark W. Beall; Robert M. O'Bara

2005-02-01T23:59:59.000Z

340

Adapting Your Home for More Accessible Living  

E-Print Network (OSTI)

It is important for people to live comfortably and independently in their homes. Homes can be adapted to aid people with various disabilities. This publication explains how to make such adaptations for people with vision loss, hearing loss, problems with touch and hand dexterity, loss of strength and range of motion, cognitive difficulties, mobility impairments, and problems with balance and coordination.

Harris, Janie

2007-04-27T23:59:59.000Z

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Adaptive learning for event modeling and characterization  

Science Conference Proceedings (OSTI)

Adaptive learning of specific patterns or events of interest has been an area of significant research for various applications in the last two decades. In developing diagnostic evaluation and safety monitoring applications of a propulsion system, it ... Keywords: Adaptive learning, Event modeling, Fuzzy k-means clustering, Hierarchical clustering

Shuangshuang Dai; Atam P. Dhawan

2007-05-01T23:59:59.000Z

342

Adaptive workflow nets for grid computing  

Science Conference Proceedings (OSTI)

Existing grid applications commonly use workflows for the orchestration of grid services. Existing workflow models however suffer from the lack of adaptivity. In this paper we define Adaptive Grid Workflow nets (AGWF nets) appropriate for modeling grid ... Keywords: coordination, grid computing, modeling, petri nets, verification, workflows

Carmen Bratosin; Kees van Hee; Natalia Sidorova

2007-09-01T23:59:59.000Z

343

Applying Adaptive Evolutionary Algorithms to Hard Problems  

E-Print Network (OSTI)

Applying Adaptive Evolutionary Algorithms to Hard Problems J.I. van Hemert1 jvhemert into two distinct parts. The main theme is adaptive evolutionary algorithms. The rst part covers. The second part mainly consists of the development of a library. Its use is aimed at evolutionary algorithms

Emmerich, Michael

344

DRM protected dynamic adaptive HTTP streaming  

Science Conference Proceedings (OSTI)

Dynamic adaptive HTTP streaming (DASH) is a new concept for video streaming using consecutive downloads of short video segments. 3GPP has developed the basic DASH standard which is further extended by the Open IPTV Forum (OIPF) and MPEG. In all versions ... Keywords: adaptive http streaming, content protection, digital rights management, encryption

Frank Hartung; Sinan Kesici; Daniel Catrein

2011-02-01T23:59:59.000Z

345

Optimal Adaptive Waveform Selection for Target Tracking  

E-Print Network (OSTI)

Optimal Adaptive Waveform Selection for Target Tracking Barbara La Scala Mohammad Rezaeian Bill algorithms. This paper describes an optimal adaptive waveform selection algorithm for target tracking. An adap- tive scheduling algorithm that selects the waveforms to be used in future epochs based on current

Rezaeian, Mohammad-Jafar

346

Adaptive sampling for Bayesian variable selection  

E-Print Network (OSTI)

Adaptive sampling for Bayesian variable selection DAVID J. NOTT Department of Statistics for variable selection and for dealing with model un- certainty have become increasingly popular in recent consider adaptive Markov chain Monte Carlo schemes for Bayesian variable selection in Gaussian linear

Blennerhassett, Peter

347

Adaptive Fuzzy PID Control for Boiler Deaerator  

Science Conference Proceedings (OSTI)

The boiler deaerator temperature control system is a non-linear, time-varying, delay control process. It can not achieve satisfying effect using traditional control algorithm to control deaerator water temperature, the paper proposes an adaptive fuzzy ... Keywords: Deaerator, Adaptive, Fuzzy control, PID control

Lei Jinli

2012-08-01T23:59:59.000Z

348

Assessing systems adaptability to a product family  

Science Conference Proceedings (OSTI)

In many cases, product families are established on top of a successful pilot product. While this approach provides an option to measure many concrete attributes like performance and memory footprint, adequateness and adaptability of the architecture ... Keywords: adaptability, assessment, product line architecture, software product lines

Mika Korhonen; Tommi Mikkonen

2004-07-01T23:59:59.000Z

349

Petascale Adaptive Computational Fluid Dynamics | Argonne Leadership  

NLE Websites -- All DOE Office Websites (Extended Search)

Petascale Adaptive Computational Fluid Dynamics Petascale Adaptive Computational Fluid Dynamics PI Name: Kenneth Jansen PI Email: jansen@rpi.edu Institution: Rensselaer Polytechnic Institute The specific aim of this request for resources is to examine scalability and robustness of our code on BG/P. We have confirmed that, during the flow solve phase, our CFD flow solver does exhibit perfect strong scaling to the full 32k cores on our local machine (CCNI-BG/L at RPI) but this will be our first access to BG/P. We are also eager to study the performance of the adaptive phase of our code. Some aspects have scaled well on BG/L (e.g., refinement has produced adaptive meshes that take a 17 million element mesh and perform local adaptivity on 16k cores to match a requested size field to produce a mesh exceeding 1 billion elements) but other aspects (e.g.,

350

Tachyons and Gravitational Cherenkov Radiation  

E-Print Network (OSTI)

AND GRAVITATIONAL CHERENKOV RADIATION CHARLES SCHWARTZwould emit gravitational radiation. It is very small.gravitational waves; Cherenkov radiation. In a recent work,

Schwartz, Charles

2011-01-01T23:59:59.000Z

351

Los Alamos Lab: Radiation Protection  

NLE Websites -- All DOE Office Websites (Extended Search)

Advisor Paul Hoover Special Assistant and Issues Management Coordinator Elinor Gwynn Radiation Protection Radiation Protection The Radiation Protection Division supports the...

352

RADIATION SAFETY OFFICE UNIVERSITYOF MARYLAND  

E-Print Network (OSTI)

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2. RADIATION EXPOSURE CONTROL . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2.2.2. Internal ExposureRADIATION SAFETY OFFICE UNIVERSITYOF MARYLAND RADIATION SAFETY MANUAL UNIVERSITY OF MARYLAND

Rubloff, Gary W.

353

Radiation Safety Work Control Form  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation Safety Work Control Form Radiation Safety Work Control Form (see instructions on pg-2) Rev July-2012 Area: Form #: Date: Preliminary Applicability Screen: (a) Will closing the beam line injection stoppers mitigate the radiological hazards introduced by the proposed work? Yes No (b) Can the closed state of the beam line injection stoppers be assured during the proposed work (ie., work does NOT involve injection stoppers or associated HPS)? Yes No If the answers to both questions are yes, the work can be performed safely under an SSRL RSWCF. If the answer to either question is no, then the work must be performed under a SPEAR3 RSWCF. Section 1: Description of work to be done, including date and time. (Person Responsible completes section)

354

Plasma Panel Based Radiation Detectors  

Science Conference Proceedings (OSTI)

The plasma panel sensor (PPS) is a gaseous micropattern radiation detector under current development. It has many operational and fabrication principles common to plasma display panels (PDPs). It comprises a dense matrix of small, gas plasma discharge cells within a hermetically sealed panel. As in PDPs, it uses non-reactive, intrinsically radiation-hard materials such as glass substrates, refractory metal electrodes, and mostly inert gas mixtures. We are developing these devices primarily as thin, low-mass detectors with gas gaps from a few hundred microns to a few millimeters. The PPS is a high gain, inherently digital device with the potential for fast response times, fine position resolution (< 50 m RMS) and low cost. In this paper we report here on prototype PPS experimental results in detecting betas, protons and cosmic muons, and we extrapolate on the PPS potential for applications including detection of alphas, heavy-ions at low to medium energy, thermal neutrons and X-rays.

Friedman, Dr. Peter S. [Integrated Sensors, LLC; Varner Jr, Robert L [ORNL; Ball, Robert [University of Michigan; Beene, James R [ORNL; Ben Moshe, M. [Tel Aviv University; Benhammou, Yan [Tel Aviv University; Chapman, J. Wehrley [University of Michigan; Etzion, E [Tel Aviv University; Ferretti, Claudio [University of Michigan; Bentefour, E [Ion Beam Applications; Levin, Daniel S. [University of Michigan; Moshe, M. [Tel Aviv University; Silver, Yiftah [Tel Aviv University; Weaverdyck, Curtis [University of Michigan; Zhou, Bing [University of Michigan

2013-01-01T23:59:59.000Z

355

Feedback based adaptive compensation of control system sensor uncertainties  

Science Conference Proceedings (OSTI)

In this paper, the problem of adaptively compensating sensor uncertainties is addressed in a feedback based framework. In this study, sensor characteristics are modeled as parametrizable uncertain functions and a compensator is constructed to adaptively ... Keywords: Adaptive control, Adaptive systems, Sensor and data fusion, Tracking and adaptation

Shanshan Li; Gang Tao

2009-02-01T23:59:59.000Z

356

Coastal Impacts, Adaptation, and Vulnerabilities  

E-Print Network (OSTI)

· Robert R. Twilley, Louisiana State University · Jordan West, U.S. Environmental Protection Agency Chapter and Restoration Authority of Louisiana · Richard Raynie, Coastal Protection and Restoration Authority of Louisiana.3.7 Emergency Response, Recovery, and Vulnerability Reduction 4.3.8 Coastal and Nearshore Oil and Ga0 4.4 Human

Kossin, James P.

357

Oak Ridge National Laboratory Radiation Control Program - Partners in Site Restoration  

SciTech Connect

In 1998, the U.S. Department of Energy (DOE) awarded the Management and Integration (M&I) contract for all five of the Oak Ridge Operations (ORO) facilities to Bechtel Jacobs Company LLC (BJC). At Oak Ridge National Laboratory (ORNL), a world renowned national laboratory and research and development facility, the BJC mission involves executing the DOE Environmental Management (EM) program. In addition to BJC's M&I contract, UT-Battelle, LLC, a not-for-profit company, is the Management and Operating (M&O) contractor for DOE on the ORNL site. As part of ORNL's EM program, legacy inactive facilities (i.e., reactors, nuclear material research facilities, burial grounds, and underground storage tanks) are transferred to BJC and are designated as remediation, decontamination and decommissioning (D&D), or long-term surveillance and maintenance (S&M) facilities. Facilities operated by both UT-Battelle and BJC are interspersed throughout the site and are usually in close proximity. Both UT-Battelle and BJC have DOE-approved Radiation Protection Programs established in accordance with 10 CFR 835. The BJC Radiological Control (RADCON) Program adapts to the M&I framework and is comprised of a combination of subcontracted program responsibilities with BJC oversight. This paper focuses on the successes and challenges of executing the BJC RADCON Program for BJC's ORNL Project through a joint M&I contractor relationship, while maintaining a positive working relationship and partnership with UT-Battelle's Radiation Protection organization.

Jones, S. L.; Stafford, M. W.

2002-02-26T23:59:59.000Z

358

Maryland Radiation Act (Maryland)  

Energy.gov (U.S. Department of Energy (DOE))

The policy of the state is to provide for the constructive use of radiation and control radiation emissions. This legislation authorizes the Department of the Environment to develop comprehensive...

359

WI Radiation Protection  

Energy.gov (U.S. Department of Energy (DOE))

This statute seeks to regulate radioactive materials, to encourage the constructive uses of radiation, and to prohibit and prevent exposure to radiation in amounts which are or may be detrimental...

360

Nonionizing Radiation and HIV  

NLE Websites -- All DOE Office Websites (Extended Search)

Nonionizing Radiation and HIV Name: Flora R Pitchford Location: NA Country: NA Date: NA Question: What are the effects of nonionizing radiation on DNA , RNA or any other cell...

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Response of the Middle Atmosphere to CO2 Doubling: Results from the Canadian Middle Atmosphere Model  

Science Conference Proceedings (OSTI)

The Canadian Middle Atmosphere Model (CMAM) has been used to examine the middle atmosphere response to CO2 doubling. The radiative-photochemical response induced by doubling CO2 alone and the response produced by changes in prescribed SSTs are ...

V. I. Fomichev; A. I. Jonsson; J. de Grandpr; S. R. Beagley; C. McLandress; K. Semeniuk; T. G. Shepherd

2007-04-01T23:59:59.000Z

362

Low Dose Radiation Research Program: Interaction between Tissue and  

NLE Websites -- All DOE Office Websites (Extended Search)

between Tissue and Cellular Stress Responses: Effect of between Tissue and Cellular Stress Responses: Effect of TGF-ß Depletion on Radiation-Induced p53 Response M.H. Barcellos-Hoff, S.A. Ravani, R.L. Henshall, K.B. Ewan, R.L. Warters,* B. Parvin Lawrence Berkeley National Laboratory *University of Utah One of the most widely studied cellular responses to radiation is the activation of the transcription factor, p53, whose abundance and action dictates individual cellular fate decisions regarding proliferation, differentiation and death. A cell's response to damage needs to be rapid. Thus, it is not surprising that the activation of the p53 stress response primarily involves post-translational changes in the p53 protein. Whereas intracellular radiation-induced mediators of p53 stability have been the subject of intense study, little is known about the extracellular factors

363

Radiation protection at CERN  

E-Print Network (OSTI)

This paper gives a brief overview of the general principles of radiation protection legislation; explains radiological quantities and units, including some basic facts about radioactivity and the biological effects of radiation; and gives an overview of the classification of radiological areas at CERN, radiation fields at high-energy accelerators, and the radiation monitoring system used at CERN. A short section addresses the ALARA approach used at CERN.

Forkel-Wirth, Doris; Silari, Marco; Streit-Bianchi, Marilena; Theis, Christian; Vincke, Heinz; Vincke, Helmut

2013-01-01T23:59:59.000Z

364

Radiation Dosimetry Data  

Science Conference Proceedings (OSTI)

Radiation Dosimetry Data. Stopping-Power and Range Tables for Electrons, Protons, and Helium Ions. MJ Berger The databases ...

2010-10-05T23:59:59.000Z

365

Radiation Shields Materials  

Science Conference Proceedings (OSTI)

About this Abstract. Meeting, Materials Science & Technology 2009. Symposium, Materials Solutions for the Nuclear Renaissance. Presentation Title, Radiation...

366

Verification and operation of adaptive materials in space.  

SciTech Connect

Piezoelectric polymers based on polyvinylidene fluoride (PVDF) are of interest as smart materials for novel space-based telescope applications. Dimensional adjustments of adaptive thin polymer films are achieved via controlled charge deposition. Predicting their long-term performance requires a detailed understanding of the piezoelectric property changes that develop during space environmental exposure. The overall materials performance is governed by a combination of chemical and physical degradation processes occurring in low Earth orbit as established by our past laboratory-based materials performance experiments (see report SAND 2005-6846). Molecular changes are primarily induced via radiative damage, and physical damage from temperature and atomic oxygen exposure is evident as depoling, loss of orientation and surface erosion. The current project extension has allowed us to design and fabricate small experimental units to be exposed to low Earth orbit environments as part of the Materials International Space Station Experiments program. The space exposure of these piezoelectric polymers will verify the observed trends and their degradation pathways, and provide feedback on using piezoelectric polymer films in space. This will be the first time that PVDF-based adaptive polymer films will be operated and exposed to combined atomic oxygen, solar UV and temperature variations in an actual space environment. The experiments are designed to be fully autonomous, involving cyclic application of excitation voltages, sensitive film position sensors and remote data logging. This mission will provide critically needed feedback on the long-term performance and degradation of such materials, and ultimately the feasibility of large adaptive and low weight optical systems utilizing these polymers in space.

Dargaville, Tim Richard; Elliott, Julie M.; Jones, Gary D.; Celina, Mathias Christopher

2006-12-01T23:59:59.000Z

367

NFkB-mediated Prosurvival Network in Low Dose Radiation-induced...  

NLE Websites -- All DOE Office Websites (Extended Search)

approaches to improve normal tissue protection in caner radiation therapy. We found that ATM, a DNA damage sensor, is induced by LDR and responsible for activation of transcription...

368

Low Dose Radiation Research Program: Radiation-Induced Nuclear Factor kB  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation-Induced Nuclear Factor kB mediates survival advantage by Radiation-Induced Nuclear Factor kB mediates survival advantage by Telomerase Activation. Authors: Natarajan M.,1 Mohan S.,2 Pandeswara, S.L.,1 and Herman T.S.1 Institutions: Departments of 1Radiation Oncology and 2Pathology, The University of Texas Health Science Center, San Antonio, Texas Activation of NF-kB in response to low doses of ionizing radiation was first shown in our laboratory. Although studies have shown that NF-kB plays an important role in anti-apoptotic function, little has been done to understand the molecular link between the activation of NF-kB and cellular outcome such as enhanced cell survival after low dose low-linear transfer (LET) radiation. Because upregulation of telomerase activity is associated with longevity and allows cells to escape from senescence, we hypothesize

369

Low Dose Radiation Research Program: Genetic Variation in Tissue...  

NLE Websites -- All DOE Office Websites (Extended Search)

Genetic Variation in Tissue Responses to Low-Dose Radiation Authors: E. M. Rinchik,1,2 P. Hoyt,3 L. Branstetter,1 R. Olszewski,1 K. T. Cain,1 and B. Voy1,3 Institutions: 1Life...

370

Low Dose Radiation Research Program: The Characterization of...  

NLE Websites -- All DOE Office Websites (Extended Search)

The Characterization of Genetic Responses to Low Dose Radiation using a Genome-Wide Insertional Mutagenesis Approach Authors: Katherine A Vallis,1,2,3 William L Stanford,4 Zhuo...

371

Low Dose Radiation Research Program: Kenneth T. Bogen  

NLE Websites -- All DOE Office Websites (Extended Search)

T. Bogen Lawrence Livermore National Laboratory Technical Abstracts 2002 Workshop: Low-dose dose-response of proliferating human cells exposed to low dose rate g-radiation. Enns,...

372

Modulating radiation induced TGFB and ATM signaling in the DNA...  

NLE Websites -- All DOE Office Websites (Extended Search)

TGF and ATM signaling in the DNA damage response Jennifer A. Anderson 1 , Francis A. Cucinotta 2 and Peter O'Neill 1 1 Gray Institute for Radiation Oncology and Biology,...

373

Rainfall and Radiative Heating Rates from TOGA COARE Atmospheric Budgets  

Science Conference Proceedings (OSTI)

Atmospheric heat and moisture budgets are used to determine rainfall and radiative heating rates over the western Pacific warm pool during the Tropical Ocean Global Atmosphere Coupled OceanAtmosphere Response Experiment (TOGA COARE). Results are ...

Richard H. Johnson; Paul E. Ciesielski

2000-05-01T23:59:59.000Z

374

Radiation Effects in Ceramic Oxide and Novel LWR Fuels  

Science Conference Proceedings (OSTI)

Jul 31, 2011 ... TMS/ASM: Nuclear Materials Committee ... of radiation response of nuclear fuel through experiment, theory and computational multi-scale modeling. ... test reactors and commercial nuclear power reactors are all of interest.

375

A New Pattern Recognition Adaptive Controller with Application to HVAC Systems  

Science Conference Proceedings (OSTI)

This paper describes a novel method for automatically adjusting the gain and integral time of proportional-integral controllers based upon patterns that characterize the closed-loop response. The method was developed for self-regulating systems that ... Keywords: Adaptive control, PI controllers, control applications, energy control, heat exchangers, pattern recognition, pressure control

John E. Seem

1998-08-01T23:59:59.000Z

376

Model reference adaptive temperature control of the electromagnetic oven process in manufacturing process  

Science Conference Proceedings (OSTI)

Nowadays, the electromagnetic ovens are used for heating the component assembly of electronic manufacturing. The control systems of the electromagnetic ovens are feedback control system and PID controller are used to control their temperature. This process ... Keywords: control theory, response optimization and model reference adaptive system

Jiraphon Srisertpol; Supot Phungphimai

2010-02-01T23:59:59.000Z

377

Low Dose Radiation Research Program: National Laboratories  

NLE Websites -- All DOE Office Websites (Extended Search)

National Laboratories National Laboratories The Low Dose Radiation Program funding encompasses several Scientific Focus Areas (SFAs). The SFAs fund merit-reviewed research at DOE national laboratories. This management approach was created in 2008 by the Office of Biological and Environmental Research (BER) within the U.S. Department of Energy's (DOE's) Office of Science. PNNL's Low Dose Radiation Research Program Scientific Focus Area Linear and Nonlinear Tissue-Signaling Mechanisms in Response to Low Dose and Low Dose-Rate Radiation This program is funded as a U.S. Department of Energy Scientific Focus Area (SFA), and is an integrated cooperative program to understand low dose radiation effects in a complex model system. Coordinating Multidisciplinary Expertise The SFAs are designed to take advantage of the multidisciplinary,

378

Standard Guide for Radiation Protection Program for Decommissioning Operations  

E-Print Network (OSTI)

1.1 This guide provides instruction to the individual charged with the responsibility for developing and implementing the radiation protection program for decommissioning operations. 1.2 This guide provides a basis for the user to develop radiation protection program documentation that will support both the radiological engineering and radiation safety aspects of the decommissioning project. 1.3 This guide presents a description of those elements that should be addressed in a specific radiation protection plan for each decommissioning project. The plan would, in turn, form the basis for development of the implementation procedures that execute the intent of the plan. 1.4 This guide applies to the development of radiation protection programs established to control exposures to radiation and radioactive materials associated with the decommissioning of nuclear facilities. The intent of this guide is to supplement existing radiation protection programs as they may pertain to decommissioning workers, members of...

American Society for Testing and Materials. Philadelphia

1987-01-01T23:59:59.000Z

379

Interphase power controller adapted to the operating conditions of networks  

Science Conference Proceedings (OSTI)

This paper introduces a new family of Interphase Power Controller (ICP) for which the useful portion of the P{sub r}-{delta}{sub sr} characteristics is shifted as the power transfer level is increased. Thus, the power characteristics of a specific IPC application can be adapted to the operating conditions of the network. The response of the IPC is compared to those of the two conventional technologies used in building it: the phase-angle regulator and series compensation. It is shown how the natural response of the IPC regulates the active power passively, without need for control action. Also, the reactive power can be controlled independently of the active power allowing for better voltage control. The new IPC retains the inherent qualities of the previous IPCs.

Brochu, J.; Beauregard, F.; Morin, G.; Pelletier, P. [CITEQ, Varennes, Quebec (Canada)] [CITEQ, Varennes, Quebec (Canada)

1995-04-01T23:59:59.000Z

380

A Model of Adaptation in Collaborative Multi-Agent Systems  

Science Conference Proceedings (OSTI)

Adaptation is an essential requirement for autonomous agent systems functioning in uncertain dynamic environments. Adaptation allows agents to change their behavior in order to improve the overall sys tem performance. We describe a general mechanism ... Keywords: adaptation, mathematical models, robotics

Kristina Lerman

2004-09-01T23:59:59.000Z

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Radioactivity and Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Radioactivity and Radiation Radioactivity and Radiation Uranium and Its Compounds line line What is Uranium? Chemical Forms of Uranium Properties of Uranium Compounds Radioactivity and Radiation Uranium Health Effects Radioactivity and Radiation Discussion of radioactivity and radiation, uranium and radioactivity, radiological health risks of uranium isotopes and decay products. Radioactivity Radioactivity is the term used to describe the natural process by which some atoms spontaneously disintegrate, emitting both particles and energy as they transform into different, more stable atoms. This process, also called radioactive decay, occurs because unstable isotopes tend to transform into a more stable state. Radioactivity is measured in terms of disintegrations, or decays, per unit time. Common units of radioactivity

382

Radiation detection system  

DOE Patents (OSTI)

A radiation detection system which utilizes the generation of Cerenkov light in and the transmission of that light longitudinally through fiber optic wave guides in order to transmit intelligence relating to the radiation to a remote location. The wave guides are aligned with respect to charged particle radiation so that the Cerenkov light, which is generated at an angle to the radiation, is accepted by the fiber for transmission therethrough. The Cerenkov radiation is detected, recorded, and analyzed at the other end of the fiber.

Nelson, Melvin A. (Santa Barbara, CA); Davies, Terence J. (Santa Barbara, CA); Morton, III, John R. (Livermore, CA)

1976-01-01T23:59:59.000Z

383

PERSONAL RADIATION MONITOR  

DOE Patents (OSTI)

A transistorized, fountain pen type radiation monitor to be worn on the person is described. Radiation produces both light flashes in a small bulb and an audible warning tone, the frequency of both the tone and light flashes being proportional to radiation intensity. The device is powered by a battery and a blocking oscillator step-up power supply The oscillator frequency- is regulated to be proportional to the radiation intensity, to provide adequate power in high radiation fields, yet minimize battery drain at low operating intensities. (AEC)

Dilworth, R.H.; Borkowski, C.J.

1961-12-26T23:59:59.000Z

384

Sandia Laboratories radiation facilities  

SciTech Connect

This brochure is designed as a basic source of information for prospective users of Sandia Laboratories Radiation Facilities. It contains a brief description of the various major radiation sources, a summary of their output characteristics, and additional information useful to experimenters. Radiation source development and source upgrading is an ongoing program, with new source configurations and modes of operation continually being devised to satisfy the ever-changing radiation requirements of the users. For most cases, the information here should allow a potential user to assess the applicability of a particular radiation facility to a proposed experiment and to permit some preirradiation calculations and planning.

Choate, L.M.; Schmidt, T.R.; Schuch, R.L.

1977-07-01T23:59:59.000Z

385

Adaptive simulation of gas turbine performance  

SciTech Connect

A method is presented allowing the simulation of gas turbine performance with the possibility of adapting to engine particularities. Measurements along the gas path are used, in order to adapt a given performance model by appropriate modification of the component maps. The proposed method can provide accurate simulation for engines of the same type, differing due to manufacturing or assembly tolerances. It doesn't require accurate component maps, as they are derived during the adaptation process. It also can be used for health monitoring purposes, introducing thus a novel approach for component condition assessment. The effectiveness of the proposed method is demonstrated by application to an industrial gas turbine.

Stamatis, A.; Mathioudakis, K.; Papailiou, K.D. (Ethnikon Metsovion Polytechneion, Athens (Greece))

1990-04-01T23:59:59.000Z

386

A Three-Dimensional Radiative Transfer Model to Investigate the Solar Radiation within a Cloudy Atmosphere. Part II: Spectral Effects  

Science Conference Proceedings (OSTI)

In this second part of a two-part paper, the spectral response of the interaction between gases, cloud droplets, and solar radiation is investigated using a Monte Carlo-based three-dimensional (3D) radiative transfer model with a spectral ...

William OHirok; Catherine Gautier

1998-10-01T23:59:59.000Z

387

Surface Radiation from GOES: A Physical Approach; Preprint  

DOE Green Energy (OSTI)

Models to compute Global Horizontal Irradiance (GHI) and Direct Normal Irradiance (DNI) have been in development over the last 3 decades. These models can be classified as empirical or physical, based on the approach. Empirical models relate ground based observations with satellite measurements and use these relations to compute surface radiation. Physical models consider the radiation received from the earth at the satellite and create retrievals to estimate surface radiation. While empirical methods have been traditionally used for computing surface radiation for the solar energy industry the advent of faster computing has made operational physical models viable. The Global Solar Insolation Project (GSIP) is an operational physical model from NOAA that computes GHI using the visible and infrared channel measurements from the GOES satellites. GSIP uses a two-stage scheme that first retrieves cloud properties and uses those properties in a radiative transfer model to calculate surface radiation. NREL, University of Wisconsin and NOAA have recently collaborated to adapt GSIP to create a 4 km GHI and DNI product every 30 minutes. This paper presents an outline of the methodology and a comprehensive validation using high quality ground based solar data from the National Oceanic and Atmospheric Administration (NOAA) Surface Radiation (SURFRAD) (http://www.srrb.noaa.gov/surfrad/sitepage.html) and Integrated Surface Insolation Study (ISIS) http://www.srrb.noaa.gov/isis/isissites.html), the Solar Radiation Research Laboratory (SRRL) at National Renewable Energy Laboratory (NREL), and Sun Spot One (SS1) stations.

Habte, A.; Sengupta, M.; Wilcox, S.

2012-09-01T23:59:59.000Z

388

NIST Optical Radiation Staff Directory  

Science Conference Proceedings (OSTI)

Optical Radiation Staff Directory. Staff. Name, Position, Office Phone. ... Contact. Optical Radiation Group Eric Shirley, Group Leader. ...

2013-08-02T23:59:59.000Z

389

NVLAP Ionizing Radiation Dosimetry LAP  

Science Conference Proceedings (OSTI)

Ionizing Radiation Dosimetry LAP. ... This site has been established for applicants to the accreditation program for ionizing radiation dosimetry. ...

2013-07-23T23:59:59.000Z

390

Radiation and Biomolecular Physics Division  

Science Conference Proceedings (OSTI)

... Welcome. The Radiation and Biomolecular Physics Division is a division ... disseminate the national standards for ionizing radiations and radioactivity ...

2012-02-08T23:59:59.000Z

391

NIST Radiation Thermometry Short Course  

Science Conference Proceedings (OSTI)

NIST Radiation Thermometry Short Course. ... 2012 NIST Radiation Thermometry Short Course October 15-19, 2012 NIST Gaithersburg, Maryland. ...

2012-10-01T23:59:59.000Z

392

NIST Ionizing Radiation Division - 2001  

Science Conference Proceedings (OSTI)

... The Ionizing Radiation Division of the Physics Laboratory supports the ... meaningful, and compatible measurements of ionizing radiations (x rays ...

393

TERSat: Trapped Energetic Radiation Satellite  

E-Print Network (OSTI)

Radiation damage caused by interactions with high-energy particles in the Van Allen Radiation Belts is a leading

Clements, Emily B.

2012-01-01T23:59:59.000Z

394

The Cost to Developing Countries of Adapting to Climate Change...  

Open Energy Info (EERE)

The Cost to Developing Countries of Adapting to Climate Change Jump to: navigation, search Tool Summary Name: The Cost to Developing Countries of Adapting to Climate Change Agency...

395

India-Vulnerability Assessment and Enhancing Adaptive Capacities...  

Open Energy Info (EERE)

Vulnerability Assessment and Enhancing Adaptive Capacities to Climate Change Jump to: navigation, search Name India-Vulnerability Assessment and Enhancing Adaptive Capacities to...

396

Climate Change Adaptation: Weighing Strategies for Heat-Related...  

NLE Websites -- All DOE Office Websites (Extended Search)

Climate Change Adaptation: Weighing Strategies for Heat-Related Health Challenges Print E-mail Climate Change Adaptation: Weighing Strategies for Heat-Related Health Challenges...

397

Ethiopia-Climate Change National Adaptation Programme of Action...  

Open Energy Info (EERE)

Adaptation Programme of Action Jump to: navigation, search Name Ethiopia-Climate Change National Adaptation Programme of Action AgencyCompany Organization United Nations...

398

Rwanda-National Adaptation Programs of Action to Climate Change...  

Open Energy Info (EERE)

Rwanda-National Adaptation Programs of Action to Climate Change Jump to: navigation, search Name Rwanda-National Adaptation Programs of Action to Climate Change AgencyCompany...

399

Burundi-National Adaptation Plan of Action to Climate Change...  

Open Energy Info (EERE)

Burundi-National Adaptation Plan of Action to Climate Change Jump to: navigation, search Name Burundi-National Adaptation Plan of Action to Climate Change AgencyCompany...

400

Using Technology to Bring Climate Change Adaptation Research...  

NLE Websites -- All DOE Office Websites (Extended Search)

Using Technology to Bring Climate Change Adaptation Research to the Great Lakes Print E-mail Using Technology to Bring Climate Change Adaptation Research to the Great Lakes...

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Adaptation to Climate Variability and Change: A Guidance Manual...  

Open Energy Info (EERE)

Adaptation to Climate Variability and Change: A Guidance Manual for Development Planning Jump to: navigation, search Tool Summary Name: Adaptation to Climate Variability and...

402

EVALUATING CONSERVATION EFFECTIVENESS AND ADAPTATION IN  

E-Print Network (OSTI)

EVALUATING CONSERVATION EFFECTIVENESS AND ADAPTATION IN DYNAMIC LANDSCAPES ADENA R. RISSMAN* I INTRODUCTION Despite the widespread use of conservation easements, their conservation outcomes are relatively unknown.1 Evaluating conservation easement effectiveness requires interdisciplinary research that reaches

Rissman, Adena

403

Robust adaptive subspace extraction for DOA tracking  

Science Conference Proceedings (OSTI)

This paper addresses the problem of extracting a time-varying signal subspace from noisy signal measurements for direction-of-arrival (DOA) estimation and tracking. A robust adaptive method for extracting the signal subspace is developed based on robust ...

Dekun Yang; S. J. Flockton

1996-05-01T23:59:59.000Z

404

Adaptive file transfers for diverse environments  

Science Conference Proceedings (OSTI)

This paper presents dsync, a file transfer system that can dynamically adapt to a wide variety of environments. While many transfer systems work well in their specialized ontext, their performance comes at the cost of generality, and they perform poorly ...

Himabindu Pucha; Michael Kaminsky; David G. Andersen; Michael A. Kozuch

2008-06-01T23:59:59.000Z

405

Information Resources: Adaptive Street Lighting Controls  

NLE Websites -- All DOE Office Websites (Extended Search)

Adaptive Street Lighting Controls Adaptive Street Lighting Controls This two-part DOE Municipal Solid-State Street Lighting Consortium webinar focused on LED street lighting equipped with adaptive control components. In Part I, presenters Amy Olay of the City of San Jose, CA, and Kelly Cunningham of the California Lighting Technology Center at UC Davis discussed their experiences as early adopters of these smart street lighting systems. In Part II, presenters Laura Stuchinsky of the City of San Jose, CA, and Michael Poplawski of Pacific Northwest National Laboratory explored the MSSLC's recently released Model Specification for Adaptive Control and Remote Monitoring of LED Roadway Luminaires. Part I: Experiences and Benefits June 11, 2013 View the presentation slides Part II: Reviewing the MSSLC's Model Specification

406

Exponential convergence with adaptive Monte Carlo  

Science Conference Proceedings (OSTI)

For over a decade, it has been known that exponential convergence on discrete transport problems was possible using adaptive Monte Carlo techniques. Now, exponential convergence has been empirically demonstrated on a spatially continuous problem.

Booth, T.E.

1997-11-01T23:59:59.000Z

407

Usability engineering for the adaptive web  

Science Conference Proceedings (OSTI)

This chapter discusses a usability engineering approach for the design and the evaluation of adaptive web-based systems, focusing on practical issues. A list of methods will be presented, considering a user-centered approach. After having introduced ...

Cristina Gena; Stephan Weibelzahl

2007-01-01T23:59:59.000Z

408

Adaptive control of a generic hypersonic vehicle  

E-Print Network (OSTI)

This thesis presents a an adaptive augmented, gain-scheduled baseline LQR-PI controller applied to the Road Runner six-degree-of-freedom generic hypersonic vehicle model. Uncertainty in control effectiveness, longitudinal ...

Wiese, Daniel Philip

2013-01-01T23:59:59.000Z

409

High Performance Adaptive Distributed Scheduling Algorithm  

Science Conference Proceedings (OSTI)

Exascale computing requires complex runtime systems that need to consider affinity, load balancing and low time and message complexity for scheduling massive scale parallel computations. Simultaneous consideration of these objectives makes online distributed ... Keywords: Distributed Scheduling, Adaptive Scheduling, Performance Analysis

Ankur Narang, Abhinav Srivastava, R. K. Shyamasundar

2013-05-01T23:59:59.000Z

410

Adaptive power management in energy harvesting systems  

Science Conference Proceedings (OSTI)

Recently, there has been a substantial interest in the design of systems that receive their energy from regenerative sources such as solar cells. In contrast to approaches that attempt to minimize the power consumption we are concerned with adapting ...

Clemens Moser; Lothar Thiele; Davide Brunelli; Luca Benini

2007-04-01T23:59:59.000Z

411

Providing Dynamic Instructional Adaptation in Programming Learning  

Science Conference Proceedings (OSTI)

This paper describes an approach to create an Intelligent Tutoring System that provides dynamic personalization and learning activities sequencing adaptation by combining eLearning standards and Artificial Intelligent techniques. The work takes advantage ...

Francisco Jurado; Olga C. Santos; Miguel A. Redondo; Jess G. Boticario; Manuel Ortega

2008-09-01T23:59:59.000Z

412

Convert! : the adaptive reuse of churches  

E-Print Network (OSTI)

This thesis examines the phenomenon of vacated churches and analyzes the major issues underlying their adaptive reuse in order to help promulgate an awareness of the range of successful strategies and solutions that are ...

Kiley, Christopher John, 1972-

2004-01-01T23:59:59.000Z

413

Model 467-1 Adapter Hardware Manual  

E-Print Network (OSTI)

-1 Adapter vi Important Notes: Make sure you follow proper ESD handling procedures (refer to EIA-625, ESD ............................................................................. 15 1.10 Interrupt And Error Handling....................................................... 16 1 Jumpers.........................................................32 3.4.6 Remote RAM Jumpers

Berns, Hans-Gerd

414

Adaptive learning of semantic locations and routes  

Science Conference Proceedings (OSTI)

Adaptation of devices and applications based on contextual information has a great potential to enhance usability and mitigate the increasing complexity of mobile devices. An important topic in context-aware computing is to learn semantic locations and ...

Keshu Zhang; Haifeng Li; Kari Torkkola; Mike Gardner

2007-09-01T23:59:59.000Z

415

Adaptive learning of semantic locations and routes  

Science Conference Proceedings (OSTI)

Adaptation of devices and applications based on contextual information has a great potential to enhance usability and mitigate the increasing complexity of mobile devices. An important topic in context-aware computing is to learn semantic locations and ...

Keshu Zhang; Haifeng Li; Kari Torkkola; Mike Gardner

2007-10-01T23:59:59.000Z

416

Dynamic Grid Adaptation Using the MPDATA Scheme  

Science Conference Proceedings (OSTI)

A dynamic grid adaptation (DGA) scheme is developed using various combinations of the multidimensional positive definite advection transport algorithm (MPDATA) to show the applicability of DGA with the MPDATA scheme to solve advection problems. A ...

John P. Iselin; Joseph M. Prusa; William J. Gutowski

2002-04-01T23:59:59.000Z

417

Statistical Design for Adaptive Weather Observations  

Science Conference Proceedings (OSTI)

Suppose that one has the freedom to adapt the observational network by choosing the times and locations of observations. Which choices would yield the best analysis of the atmospheric state or the best subsequent forecast? Here, this problem of ...

L. Mark Berliner; Zhan-Qian Lu; Chris Snyder

1999-08-01T23:59:59.000Z

418

Adaptive nonparametric regression on spin fiber bundles  

Science Conference Proceedings (OSTI)

The construction of adaptive nonparametric procedures by means of wavelet thresholding techniques is now a classical topic in modern mathematical statistics. In this paper, we extend this framework to the analysis of nonparametric regression on sections ... Keywords: 42B35, 42C10, 42C40, 46E35, 62G08, 62G20, Adaptive nonparametric regression, Mixed spin needlets, Spin Besov spaces, Spin fiber bundles, Thresholding

Claudio Durastanti; Daryl Geller; Domenico Marinucci

2012-02-01T23:59:59.000Z

419

Health physics applications of nuclear safeguards radiation monitors  

SciTech Connect

Nuclear safeguards needs fostered the development of radiation monitors whose sensitivity and microprocessor-controlled logic permit detection of small, transient increases in environmental levels of gamma radiation. While this capability was originally developed to detect the diversion of the special nuclear materials /sup 235/U and plutonium, adaptation to health physics monitoring is straigthforward. Applications of the safeguards instruments range from small, handheld instruments used to monitor laundry of salvage-bound materials to more complex systems devoted to monitoring moving vehicles at entry/exit points. In addition to these health physics applications, other new applications for safeguards instruments are being considered.

Fehlau, P.E.; Dvorak, R.F.

1984-01-01T23:59:59.000Z

420

Solar radiation model validation  

Science Conference Proceedings (OSTI)

Several mathematical models have been developed within the past few years which estimate the solar radiation from other weather variables. Some of these models have been used to generate data bases which are extensively used in the design and analysis of solar system. Three of these solar radiation models have been used in developing the Augmented SOLMET Solar Data Tapes for the 26 SOLMET sites and the 222 ERSATZ Solar Data Tapes. One of the models, a theoretical one, predicts the solar noon radiation for clear sky conditions from the optical air mass, precipitable water vapor and turbidity variables. A second model, an empirical one, predicts the hourly total horizontal radiation from meteorological variables. And, a third model, also an empirical one, predicts the hourly direct normal radiation from the hourly total horizontal radiation. A study of the accuracy of these three solar radiation models is reported here. To assess the accuracy of these models, data were obtained from several US National Weather Service Stations and other sources, used the models to estimate the solar-radiation, and then compared the modeled radiation values with observed radiation values. The results of these comparisons and conclusions regarding the accuracy of the models are presented.

Hall, I.J.; Prairie, R.R.; Anderson, H.E.; Boes, E.C.

1980-10-01T23:59:59.000Z

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Exelon response  

Energy.gov (U.S. Department of Energy (DOE))

This letter constitutes the response of Exelon Generation Company, LLC and its operating unit,Exelon Nuclear Partners, to the Department of Energysrequest for comments and information (July 27,...

422

Documentation for the intergalactic radiative transfer code IGMtransfer  

E-Print Network (OSTI)

This document describes the publically available numerical code "IGMtransfer", capable of performing intergalactic radiative transfer (RT) of light in the vicinity of the Lyman alpha (Lya) line. Calculating the RT in a (possibly adaptively refined) grid of cells resulting from a cosmological simulation, the code returns 1) a "transmission function", showing how the intergalactic medium (IGM) affects the Lya line at a given redshift, and 2) the "average transmission" of the IGM, making it useful for studying the results of reionization simulations.

Laursen, Peter

2010-01-01T23:59:59.000Z

423

Atmospheric Radiation Measurement Program  

NLE Websites -- All DOE Office Websites (Extended Search)

3 3 ARM 2003 Tom Ackerman Chief Scientist Tom Ackerman Chief Scientist ARM ARM Atmospheric Radiation Measurement Atmospheric Radiation Measurement WARNING! WARNING! Today is April 1 But that has NO bearing on this message Today is April 1 But that has NO bearing on this message ARM ARM Atmospheric Radiation Measurement Atmospheric Radiation Measurement Two Topics Two Topics * Status of ARM (quick overview) * Science plan - ARM in the next 5 years * Status of ARM (quick overview) * Science plan - ARM in the next 5 years ARM ARM Atmospheric Radiation Measurement Atmospheric Radiation Measurement ARM Status - Science ARM Status - Science * Steadily increasing productivity - Poster session - over 220 posters (may need to do something about submissions next year) - Peer-reviewed articles: 2.5 to 3 per year per

424

RADIATION WAVE DETECTION  

DOE Patents (OSTI)

Radiation waves can be detected by simultaneously measuring radiation- wave intensities at a plurality of space-distributed points and producing therefrom a plot of the wave intensity as a function of time. To this end. a detector system is provided which includes a plurality of nuclear radiation intensity detectors spaced at equal radial increments of distance from a source of nuclear radiation. Means are provided to simultaneously sensitize the detectors at the instant a wave of radiation traverses their positions. the detectors producing electrical pulses indicative of wave intensity. The system further includes means for delaying the pulses from the detectors by amounts proportional to the distance of the detectors from the source to provide an indication of radiation-wave intensity as a function of time.

Wouters, L.F.

1960-08-30T23:59:59.000Z

425

Effects of atomic radiation  

SciTech Connect

This book focuses on the lifelong effects of atomic radiation exposure in language understandable by the concerned layperson or the specialist in another field. The base of knowledge used is the work of the Atomic Bomb Casualty Commission and its successor since 1975 the Radiation Effects Research Foundation. Within the range of Chronic effects on human health the book provides a thorough review, although effects of nonionizing radiation, effects on structures, effects on other living species, and acute effects are not discussed.

Schull, W.J.

1995-12-31T23:59:59.000Z

426

Radiation coloration resistant glass  

SciTech Connect

A radiation coloration resistant glass is disclosed which is used in a radiation environment sufficient to cause coloration in most forms of glass. The coloration resistant glass includes higher proportions by weight of water and has been found to be extremely resistant to color change when exposed to such radiation levels. The coloration resistant glass is free of cerium oxide and has more than about 0.5% by weight water content. Even when exposed to gamma radiation of more than 10.sup.7 rad, the coloration resistant glass does not lose transparency.

Tomozawa, Minoru (Troy, NY); Watson, E. Bruce (Troy, NY); Acocella, John (Troy, NY)

1986-01-01T23:59:59.000Z

427

Radiation Shielding Applications  

NLE Websites -- All DOE Office Websites (Extended Search)

Shielding Radiation Shielding Applications Heavy concrete is standard concrete in which conventional aggregate (typically gravel) is replaced with aggregate composed of a dense...

428

Radiation Hazards Program (Minnesota)  

Energy.gov (U.S. Department of Energy (DOE))

These regulations, promulgated by the Department of Health, set allowable radiation standards and mitigation practices, as well as procedures for the transportation of hazardous material.

429

Synchrotron Radiation Effects  

NLE Websites -- All DOE Office Websites (Extended Search)

Synchrotron Radiation Effects in the IR Solenoid Flux Excluder Peter Tenenbaum LCC-Note-0007 Draft 23-September-1998 Abstract We examine the emittance dilution due to synchrotron...

430

Human Radiation Experiments: Multimedia  

NLE Websites -- All DOE Office Websites (Extended Search)

the oral histories of researchers and others possessing firsthand knowledge of human radiation experimentation during World War II and the Cold War. Film Clips: Document...

431

Atomic Radiation (Illinois)  

Energy.gov (U.S. Department of Energy (DOE))

This article states permissible levels of radiation in unrestricted areas, environmental standards for uranium fuel cycle and information about notification of incidents.

432

Quick Reference Information - Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Gamma and x-rays are photons. Protons: Positively charged elementary particles found in atomic nuclei. Radiation: The propagation of energy through space, or some other medium,...

433

Living with radiation  

SciTech Connect

The authors present an account of the hopes and fears associated with ionizing radiation, extending from nuclear energy and medical radiation to nuclear weapons. They argue that a justified fear of nuclear weapons has led to a widespread, unjustified, and unreasoning fear of the beneficial applications of radiation. Although these two aspects of atomic energy are tied together-they both involve the nucleus of the atom and its radioactive rays-a deep misunderstanding of this relationship by the general public has evolved since the time of the atomic bombing of Hiroshima and Nagasaki. The authors' aim is to place the beneficial applications of nuclear radiation in perspective.

Wagner, H.N. Jr. (Johns Hopkins Medical Institutions, Baltimore, MD (USA). Div. of Nuclear Medicine); Ketchum, L.E. (Proclinica, Inc., New York, NY (US))

1989-01-01T23:59:59.000Z

434

Carbonaceous Aerosols and Radiative...  

NLE Websites -- All DOE Office Websites (Extended Search)

Aerosols and Radiative Effects Study Science Objective This field campaign is designed to increase scientific knowledge about the evolution of black carbon, primary organic...

435

Low Dose Radiation Research Program: Linking Molecular Events to Cellular  

NLE Websites -- All DOE Office Websites (Extended Search)

Linking Molecular Events to Cellular Responses at Low Dose Exposures Linking Molecular Events to Cellular Responses at Low Dose Exposures Thomas Weber Pacific Northwest National Laboratory Why This Project It currently costs billions of dollars to protect workers and the public from exposure to man-made radiation, despite exposure levels lower than the natural background levels of radiation. If it could be demonstrated that there is no increased cancer risk associated with these low dose exposures, these resources could be directed toward more critical societal issues. Defining low dose radiation cancer risks is limited by our ability to measure and directly correlate relevant cellular and molecular responses occurring at the low radiation dose and dose rate with tumor formation. This deficiency has led to conservative risk assessments based on low dose

436

THE MIGRATION MECHANISM OF RADIATION PROTECTION  

SciTech Connect

An hypothesis concerning the primary mechanism of the biological action of radiation is presented. The energy absorbed either directly or indirectly on irradiation is assumed to damage the system in the course of migrating either within or between the protein or other macromolecules. Some of the damage responsible for the physio-chemical radiation after-effects is retained in ihe macromolecules as long-lived electronically excited states. It does not escape and in time produces additional effects. It is suggested thai this damage can be removed by intermolecular energy migration to some protective agent which forms a complex with the macromolecules. (C.H.)

Eidus, L.Kh.; Kalamkarova, M.B.; Otarova, G.K.

1958-01-01T23:59:59.000Z

437

CASTRO: A NEW COMPRESSIBLE ASTROPHYSICAL SOLVER. III. MULTIGROUP RADIATION HYDRODYNAMICS  

SciTech Connect

We present a formulation for multigroup radiation hydrodynamics that is correct to order O(v/c) using the comoving-frame approach and the flux-limited diffusion approximation. We describe a numerical algorithm for solving the system, implemented in the compressible astrophysics code, CASTRO. CASTRO uses a Eulerian grid with block-structured adaptive mesh refinement based on a nested hierarchy of logically rectangular variable-sized grids with simultaneous refinement in both space and time. In our multigroup radiation solver, the system is split into three parts: one part that couples the radiation and fluid in a hyperbolic subsystem, another part that advects the radiation in frequency space, and a parabolic part that evolves radiation diffusion and source-sink terms. The hyperbolic subsystem and the frequency space advection are solved explicitly with high-order Godunov schemes, whereas the parabolic part is solved implicitly with a first-order backward Euler method. Our multigroup radiation solver works for both neutrino and photon radiation.

Zhang, W.; Almgren, A.; Bell, J. [Center for Computational Sciences and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Howell, L. [Center for Applied Scientific Computing, Lawrence Livermore National Laboratory, Livermore, CA 94550 (United States); Burrows, A.; Dolence, J. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States)

2013-01-15T23:59:59.000Z

438

Brief An adaptive PID learning control of robot manipulators  

Science Conference Proceedings (OSTI)

An adaptive PID learning controller which consists of an adaptive PID feedback control scheme and a feedforward input learning scheme is proposed for learning of periodic robot motion. In the learning controller, the adaptive PID feedback controller ... Keywords: Adaptive PID learning, Learning rules, Robot motion control

Tae-Yong Kuc; Woong-Gie Han

2000-05-01T23:59:59.000Z

439

UNDP-Adaptation Learning Mechanism | Open Energy Information  

Open Energy Info (EERE)

Adaptation Learning Mechanism Adaptation Learning Mechanism Jump to: navigation, search Logo: UNDP-Adaptation Learning Mechanism Name UNDP-Adaptation Learning Mechanism Agency/Company /Organization United Nations Development Programme Sector Climate, Energy, Land, Water Topics Adaptation Resource Type Lessons learned/best practices, Training materials Website http://www.adaptationlearning. Program Start 2007 References Adaptation Learning Mechanism[1] Abstract Seeking to provide stakeholders with a common platform for sharing and learning, the ALM bridges knowledge gaps by bringing relevant knowledge and stakeholders together to exchange information, experiences, and expertise. Additionally, the ALM complements the wide range of adaptation knowledge networks and initiatives already underway.

440

Low Dose Radiation Research Program: Molecular Characterization of the  

NLE Websites -- All DOE Office Websites (Extended Search)

Molecular Characterization of the Roles of SOD Genes in Mammalian Molecular Characterization of the Roles of SOD Genes in Mammalian Cellular Response to Low Dose Radiation Authors: Chuan-Yuan Li, Zhanjun Guo, Zhonghui Yang, and Eric Chuang Institutions: Dept of Radiation Oncology, Duke University Medical Center, Durham, NC Advanced Technology Center, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Background The potential risks of exposure to low dose radiation are of major concerns to the DOE/OBER Low Dose Radiation Research Program. It has been long recognized that much of the radiation-induced genetic damage to cells are caused by secondary oxidative species. Therefore internal cellular defense systems against oxidative stress play significant roles in countering genetic damage induced by ionizing radiation. The role of the detoxifying

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Solar radiation data sources, applications, and network design  

DOE Green Energy (OSTI)

A prerequisite to considering solar energy projects is to determine the requirements for information about solar radiation to apply to possible projects. This report offers techniques to help the reader specify requirements in terms of solar radiation data and information currently available, describes the past and present programs to record and present information to be used for most requirements, presents courses of action to help the user meet his needs for information, lists sources of solar radiation data and presents the problems, costs, benefits and responsibilities of programs to acquire additional solar radiation data. Extensive background information is provided about solar radiation data and its use. Specialized information about recording, collecting, processing, storing and disseminating solar radiation data is given. Several Appendices are included which provide reference material for special situations.

None

1978-04-01T23:59:59.000Z

442

Low Dose Radiation Research Program: 2003 Molecular Characterization of the  

NLE Websites -- All DOE Office Websites (Extended Search)

Characterization of the Roles of SOD Genes in Mammalian Characterization of the Roles of SOD Genes in Mammalian Cellular Response to Low Dose Radiation Authors: Chuan-Yuan Li,1 Eric Chuang2 Institutions: 1Dept of Radiation Oncology, Duke University Medical Center, Durham, NC, 2Advanced Technology Center, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland The potential risks of exposure to low dose radiation are of major concerns to the DOE/OBER Low Dose Radiation Research Program. It has been long recognized that much of the radiation-induced genetic damage to cells are caused by secondary oxidative species. Therefore, internal cellular defense systems against oxidative stress play significant roles in countering genetic damage induced by ionizing radiation. The role of the detoxifying

443

Solid-State Lighting: Adaptive Street Lighting Controls  

NLE Websites -- All DOE Office Websites (Extended Search)

Adaptive Street Lighting Adaptive Street Lighting Controls to someone by E-mail Share Solid-State Lighting: Adaptive Street Lighting Controls on Facebook Tweet about Solid-State Lighting: Adaptive Street Lighting Controls on Twitter Bookmark Solid-State Lighting: Adaptive Street Lighting Controls on Google Bookmark Solid-State Lighting: Adaptive Street Lighting Controls on Delicious Rank Solid-State Lighting: Adaptive Street Lighting Controls on Digg Find More places to share Solid-State Lighting: Adaptive Street Lighting Controls on AddThis.com... Conferences & Meetings Presentations Publications Webcasts Videos Tools Adaptive Street Lighting Controls This two-part DOE Municipal Solid-State Street Lighting Consortium webinar focused on LED street lighting equipped with adaptive control components.

444

An architecture for adaptive intrusion-tolerant applications: Experiences with Auto-adaptive and Reconfigurable Systems  

Science Conference Proceedings (OSTI)

Applications that are part of a mission-critical information system need to maintain a usable level of key services through ongoing cyber-attacks. In addition to the well-publicized denial of service (DoS) attacks, these networked and distributed applications ... Keywords: Byzantine fault tolerance, adaptive defense, adaptive middleware, intrusion tolerance, redundancy, survivability architecture

Partha Pal; Paul Rubel; Michael Atighetchi; Franklin Webber; William H. Sanders; Mouna Seri; HariGovind Ramasamy; James Lyons; Tod Courtney; Adnan Agbaria; Michel Cukier; Jeanna Gossett; Idit Keidar

2006-09-01T23:59:59.000Z

445

Evaluation of a personalized digital library based on cognitive styles: Adaptivity vs. adaptability  

Science Conference Proceedings (OSTI)

Personalization can be addressed by adaptability and adaptivity, which have different advantages and disadvantages. This study investigates how digital library (DL) users react to these two techniques. More specifically, we develop a personalized DL ... Keywords: Cognitive styles, Digital libraries, Individual differences, Personalization

Enrique Frias-Martinez; Sherry Y. Chen; Xiaohui Liu

2009-02-01T23:59:59.000Z

446

Adaptation of user views to business requirements: towards adaptive views models  

Science Conference Proceedings (OSTI)

This article describes an approach to model user views in service-oriented groupware systems in order to support the adaptation of views in collaborative projects environments. The issue is to adapt the visualization to the users' business requirements ... Keywords: AEC (architecture engineering construction), CSCW, information visualization, model driven engineering, user view, user view model

Conrad Boton; Sylvain Kubicki; Gilles Halin

2010-09-01T23:59:59.000Z

447

Research priorities for occupational radiation protection  

Science Conference Proceedings (OSTI)

The Subpanel on Occupational Radiation Protection Research concludes that the most urgently needed research is that leading to the resolution of the potential effects of low-level ionizing radiation. This is the primary driving force in setting appropriate radiation protection standards and in directing the emphasis of radiation protection efforts. Much has already been done in collecting data that represents a compendium of knowledge that should be fully reviewed and understood. It is imperative that health physics researchers more effectively use that data and apply the findings to enhance understanding of the potential health effects of low-level ionizing radiation and improve the risk estimates upon which current occupational radiation protection procedures and requirements depend. Research must be focused to best serve needs in the immediate years ahead. Only then will we get the most out of what is accomplished. Beyond the above fundamental need, a number of applied research areas also have been identified as national priority issues. If effective governmental focus is achieved on several of the most important national priority issues, important occupational radiation protection research will be enhanced, more effectively coordinated, and more quickly applied to the work environment. Response in the near term will be enhanced and costs will be reduced by: developing microprocessor-aided {open_quotes}smart{close_quotes} instruments to simplify the use and processing of radiation data; developing more sensitive, energy-independent, and tissue-equivalent dosimeters to more accurately quantify personnel dose; and developing an improved risk assessment technology base. This can lead to savings of millions of dollars in current efforts needed to ensure personnel safety and to meet new, more stringent occupational guidelines.

Not Available

1994-02-01T23:59:59.000Z

448

ORISE: Radiation Emergency Assistance Center/Training Site (REAC/TS)  

NLE Websites -- All DOE Office Websites (Extended Search)

How ORISE is Making a Difference How ORISE is Making a Difference Overview CBL International Exercise Emergency Response Training International Training RANET Asset CBL BioDoseNet CBL's Empire 09 Support NASA Support International Partnerships Resources Overview Frequently Asked Questions about Radiation Understanding Radiation Video Series The Medical Aspects of Radiation Incidents Dose Estimates and Compendia Procedure Demonstrations for Contaminated Patients Hospital Triage Article Radiation Treatment Medication Package Inserts Cytogenetic Biodosimetry Laboratory Video Cytogenetic Biodosimetry Laboratory Brochure Dose Coefficients for Intakes of Radionuclides via Contaminated Wounds How to Work With Us Contact Us Featured Resources The Medical Aspects of Radiation Incidents The Medical Aspects of Radiation Incidents

449

Adaptation to water scarcity in glacier-dependent towns of the Indian Himalayas : impacts, adaptive responses, barriers, and solutions  

E-Print Network (OSTI)

Among the existing and projected impacts of climate change, impacts on water resources are expected to exacerbate the current and future threat of global water scarcity. Glacier-dependent societies are especially vulnerable ...

Sudhalkar, Amruta Anand

2010-01-01T23:59:59.000Z

450

Radiation detection system  

SciTech Connect

A radiation detection system including a radiation-to-light converter and fiber optic wave guides to transmit the light to a remote location for processing. The system utilizes fluors particularly developed for use with optical fibers emitting at wavelengths greater than about 500 nm and having decay times less than about 10 ns.

Franks, Larry A. (Santa Barbara, CA); Lutz, Stephen S. (Santa Barbara, CA); Lyons, Peter B. (Los Alamos, NM)

1981-01-01T23:59:59.000Z

451

Solar radiation modelling  

Science Conference Proceedings (OSTI)

The Sun is the main energy source of the life on the Earth. Thus, solar radiation energy data and models are important for many areas of research and applications. Many parameters influence the amount of solar energy at a particular standing point of ... Keywords: Digital elevation model, Energy of quasiglobal radiation, Meteorology, Shadows, Virtual Sun motion

Klemen Zakek; Toma Podobnikar; Kritof Otir

2005-03-01T23:59:59.000Z

452

Electromagnetic radiation detector  

DOE Patents (OSTI)

An electromagnetic radiation detector including a collimating window, a cathode member having a photoelectric emissive material surface angularly disposed to said window whereby radiation is impinged thereon at acute angles, an anode, separated from the cathode member by an evacuated space, for collecting photoelectrons emitted from the emissive cathode surface, and a negatively biased, high transmissive grid disposed between the cathode member and anode.

Benson, Jay L. (Albuquerque, NM); Hansen, Gordon J. (Albuquerque, NM)

1976-01-01T23:59:59.000Z

453

Disposition Schedule: Human Radiation Experiments | Department...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Schedule: Human Radiation Experiments Disposition Schedule: Human Radiation Experiments This database contains information on records collections related to human radiation...

454

The Quasi-stationary Structure of Radiating Shock Waves; 1, The One-temperature Fluid  

E-Print Network (OSTI)

We calculate the quasi-stationary structure of a radiating shock wave propagating through a spherically symmetric shell of cold gas by solving the time-dependent equations of radiation hydrodynamics on an adaptive grid. We show that this code successfully resolves the shock wave in both the subcritical and supercritical cases and, for the first time, we have reproduced all the expected features -- including the optically thin temperature spike at a supercritical shock front -- without invoking analytic jump conditions at the discontinuity. We solve the full moment equations for the radiation flux and energy density, but the shock wave structure can also be reproduced if the radiation flux is assumed to be proportional to the gradient of the energy density (the diffusion approximation), as long as the radiation energy density is determined by the appropriate radiative transfer moment equation. We find that Zel'dovich and Raizer's analytic solution for the shock wave structure accurately describes a subcritical...

Sincell, M W; Mihalas, D L

1997-01-01T23:59:59.000Z

455

Petascale, Adaptive CFD | Argonne Leadership Computing Facility  

NLE Websites -- All DOE Office Websites (Extended Search)

Petascale, Adaptive CFD Petascale, Adaptive CFD Petascale, Adaptive CFD PI Name: Kenneth Jansen PI Email: jansenke@colorado.edu Institution: U. Colorado-Boulder Allocation Program: ESP Allocation Hours at ALCF: 150 Million Year: 2010 to 2013 Research Domain: Engineering The aerodynamic simulations proposed will involve modeling of active flow control based on synthetic jet actuation that has been shown experimentally to produce large-scale flow changes (e.g., re-attachment of separated flow or virtual aerodynamic shaping of lifting surfaces) from micro-scale input (e.g., a 0.1 W piezoelectric disk resonating in a cavity alternately pushes/pulls out/in the fluid through a small slit to create small-scale vortical structures that interact with, and thereby dramatically alter, the cross flow). This is a process that has yet to be understood fundamentally.

456

AdaptiveARC | Open Energy Information  

Open Energy Info (EERE)

AdaptiveARC AdaptiveARC Jump to: navigation, search Name AdaptiveARC Address 7683 Sitio Manana Place Carlsbad, California Zip 92009 Sector Biomass Product Waste-to-clean-energy startup is developing an arc-plasma reactor Website http://www.adaptivearc.com/ Coordinates 33.07959°, -117.22539° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":33.07959,"lon":-117.22539,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

457

Load attenuating passively adaptive wind turbine blade  

DOE Patents (OSTI)

A method and apparatus for improving wind turbine performance by alleviating loads and controlling the rotor. The invention employs the use of a passively adaptive blade that senses the wind velocity or rotational speed, and accordingly modifies its aerodynamic configuration. The invention exploits the load mitigation prospects of a blade that twists toward feather as it bends. The invention includes passively adaptive wind turbine rotors or blades with currently preferred power control features. The apparatus is a composite fiber horizontal axis wind-turbine blade, in which a substantial majority of fibers in the blade skin are inclined at angles of between 15 and 30 degrees to the axis of the blade, to produces passive adaptive aeroelastic tailoring (bend-twist coupling) to alleviate loading without unduly jeopardizing performance.

Veers, Paul S. (Albuquerque, NM); Lobitz, Donald W. (Albuquerque, NM)

2003-01-01T23:59:59.000Z

458

Fast adaptive elliptical filtering using box splines  

E-Print Network (OSTI)

We demonstrate that it is possible to filter an image with an elliptic window of varying size, elongation and orientation with a fixed computational cost per pixel. Our method involves the application of a suitable global pre-integrator followed by a pointwise-adaptive localization mesh. We present the basic theory for the 1D case using a B-spline formalism and then appropriately extend it to 2D using radially-uniform box splines. The size and ellipticity of these radially-uniform box splines is adaptively controlled. Moreover, they converge to Gaussians as the order increases. Finally, we present a fast and practical directional filtering algorithm that has the capability of adapting to the local image features.

Chaudhury, Kunal Narayan; Unser, Michael

2009-01-01T23:59:59.000Z

459

Underwater radiation detector  

DOE Patents (OSTI)

A detector apparatus for differentiating between gamma and neutron radiation is provided. The detector includes a pair of differentially shielded Geiger-Mueller tubes. The first tube is wrapped in silver foil and the second tube is wrapped in lead foil. Both the silver and lead foils allow the passage of gamma rays at a constant rate in a gamma ray only field. When neutrons are present, however, the silver activates and emits beta radiation that is also detected by the silver wrapped Geiger-Mueller tube while the radiation detected by the lead wrapped Geiger-Mueller tube remains constant. The amount of radiation impinging on the separate Geiger-Mueller tubes is then correlated in order to distinguish between the neutron and gamma radiations.

Kruse, Lyle W. (Albuquerque, NM); McKnight, Richard P. (Albuquerque, NM)

1986-01-01T23:59:59.000Z

460

Fundamentals of Radiation Dosimetry  

Science Conference Proceedings (OSTI)

The basic concepts of radiation dosimetry are reviewed on basis of ICRU reports and text books. The radiation field is described with, among others, the particle fluence. Cross sections for indirectly ionizing radiation are defined and indicated is how they are related to the mass energy transfer and mass energy absorption coefficients. Definitions of total and restricted mass stopping powers of directly ionizing radiation are given. The dosimetric quantities, kerma, absorbed dose and exposure together with the relations between them are discussed in depth. Finally it is indicated how the absorbed dose can be measured with a calorimeter by measuring the temperature increase and with an ionisation chamber measuring the charge produced by the ionizing radiation and making use of the Bragg-Gray relation.

Bos, Adrie J. J. [Delft University of Technology, Faculty of Applied Sciences, Mekelweg 15, 2629JB Delft (Netherlands)

2011-05-05T23:59:59.000Z

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Radiation effects on humans  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation effects on humans Radiation effects on humans Name: Joe Kemna Location: N/A Country: N/A Date: N/A Question: I am trying to find information on radiation. I need the effects on humans, the damage it causes to the environment, and any extra information you might have on the subject. Thank you for your time. Replies: Your library should be a good place to start, but first you need to narrow your question a bit. "Radiation" means radio waves, heat, light (including the ultraviolet light that causes suntan and sunburn), and what's called "ionizing radiation." By far the major source of the first three is the Sun, while the last I believe comes principally from cosmic rays and various naturally radioactive elements like uranium and radon. The most significant manmade sources of exposure would --- I think --- be household wiring and appliances (radio), engines and heating devices (heat), lamps (light), and X-ray machines, flying at high altitude in airplanes, and living in well-insulated homes built over radon sources (ionizing radiation). Heat, light and ionizing radiation play vital roles in the ecology of the Earth. Radio, light (in particular "tanning" ultraviolet), and ionizing radiation have all been widely assumed at different times to be particularly good or particularly bad for human health. Some recent issues of public concern have been the effect of radio waves from electric transmission lines, the effect on skin cancer incidence from tanning and sunburns, the depletion of the ultraviolet-light-produced ozone in the upper atmosphere by chlorofluorocarbons (CFCs), "global warming" from the increased absorption of heat radiation from the surface by atmospheric carbon dioxide and methane, and the effect of a long exposure to low levels of ionizing radiation as for example the people of Eastern Europe are experiencing from the Chernobyl nuclear power plant accident.

462

A SINGLE-PARAMETER ADAPTIVE COMB FILTER  

E-Print Network (OSTI)

The study is concerned with a single-parameter adaptive comb filter (ACF), a multi-notch filter with periodically located nulls. The filter is suggested to retrieve a waveform modeled by superposition of harmonics, in particular, periodic non-sinusoidal signal. Using trigonometric constraints between the signal fundamental frequency and over tones results in a non-linear estimation problem. In the present study, the parameter adjustment relies on the extended Kalman filter scheme. Particularly, the 2, 3 and 4 notch ACF are derived and tested under different conditions. Given a multi-tone scenario, the ACF significantly outperforms common adaptive multi-notch filter.

Single-Parameter Adaptive Comb; Naum G. Chernoguz

2001-01-01T23:59:59.000Z

463

Low Dose Radiation Program: Links - Organizations Funding Radiation...  

NLE Websites -- All DOE Office Websites (Extended Search)

Funding Radiation Research Australian Radiation Protection and Nuclear Safety Agency Canadian Nuclear Safety Commission Centers for Medical Countermeasures Against Radiological and...

464

National Solar Radiation Data Base

The National Solar Radiation...  

Open Energy Info (EERE)

National Solar Radiation Data Base (NSRDB) is the most comprehensive collection of solar data freely available. The 1991 - 2005 NSRDB contains hourly solar radiation (including...

465

Essays on Agricultural Adaptation to Climate Change and Ethanol Market Integration in the U.S.  

E-Print Network (OSTI)

Climate factors like precipitation and temperature, being closely intertwined with agriculture, make a changing climate a big concern for the entire human race and its basic survival. Adaptation to climate is a long-running characteristic of agriculture evidenced by the varying types and forms of agricultural enterprises associated with differing climatic conditions. Nevertheless climate change poses a substantial, additional adaptation challenge for agriculture. Mitigation encompasses efforts to reduce the current and future extent of climate change. Biofuels production, for instance, expands agricultures role in climate change mitigation. This dissertation encompasses adaptation and mitigation strategies as a response to climate change in the U.S. by examining comprehensively scientific findings on agricultural adaptation to climate change; developing information on the costs and benefits of select adaptations to examine what adaptations are most desirable, for which society can further devote its resources; and studying how ethanol prices are interrelated across, and transmitted within the U.S., and the markets that play an important role in these dynamics. Quantitative analysis using the Forestry and Agricultural Sector Optimization Model (FASOM) shows adaptation to be highly beneficial to agriculture. On-farm varietal and other adaptations contributions outweigh a mix shift northwards significantly, implying progressive technical change and significant returns to adaptation research and investment focused on farm management and varietal adaptations could be quite beneficial over time. Northward shift of corn-acre weighted centroids observed indicates that substantial production potential may shift across regions with the possibility of less production in the South, and more in the North, and thereby, potential redistribution of income. Time series techniques employed to study ethanol price dynamics show that the markets studied are co-integrated and strongly related, with the observable high levels of interaction between all nine cities. Information is transmitted rapidly between these markets. Price seems to be discovered (where shocks originate from) in regions of high demand and perhaps shortages, like Los Angeles and Chicago (metropolitan population centers). The Maximum Likelihood approach following Spiller and Huangs model however shows cities may not belong to the same economic market and the possibility of arbitrage does not exist between all markets.

Aisabokhae, Ruth 1980-

2012-12-01T23:59:59.000Z

466

The Properties of Undulator Radiation  

E-Print Network (OSTI)

of a Dedicated Synchrotron Radiation Facility," IEEE Trans.1983), "Characteristics of Synchrotron Radiation and of itsHandbook on Synchrotron Radiation, E. -E. Koch.1A. 65-172,

Howells, M.R.

2011-01-01T23:59:59.000Z

467

Coherent Radiation in an Undulator  

E-Print Network (OSTI)

solving the particle-radiation system in a self-consistentto clarify the coherent radiation mechanism. References 1.the Proceedings Coherent Radiation in an Undulator Y,H. Chin

Chin, Y.H.

2011-01-01T23:59:59.000Z

468

A National Strategy for Adaptation to Climate Change | Open Energy  

Open Energy Info (EERE)

A National Strategy for Adaptation to Climate Change A National Strategy for Adaptation to Climate Change Jump to: navigation, search Tool Summary Name: A National Strategy for Adaptation to Climate Change Agency/Company /Organization: Coalition for Rainforest Nations Topics: Adaptation, Pathways analysis Resource Type: Guide/manual Website: www.rainforestcoalition.org/eng/ References: A National Strategy for Adaptation to Climate Change[1] Logo: A National Strategy for Adaptation to Climate Change Click here to view document A National Strategy for Adaptation to Climate Change References ↑ "A National Strategy for Adaptation to Climate Change" Retrieved from "http://en.openei.org/w/index.php?title=A_National_Strategy_for_Adaptation_to_Climate_Change&oldid=382940" Category: Tools

469

NVLAP Radiation Detection Instruments LAP  

Science Conference Proceedings (OSTI)

Radiation Detection Instruments LAP. Leticia Pibida uses a hand-held radiation detection device to check cargo. Photo: Copyright Robert Rathe. ...

2013-07-23T23:59:59.000Z

470

Human Radiation Experiments: What's New  

NLE Websites -- All DOE Office Websites (Extended Search)

of Defense Report Finding Aids Department of Defense Report on Search for Human Radiation Experiments Records 1944-1994 Exit Human Radiation Experiments Site This...

471

Radiation Effects in Nanoporous Gold  

Science Conference Proceedings (OSTI)

Foams with filament and porous sizes in the range of nanometers could be unusually resistant to radiation because radiation induced point defects cannot...

472

2009 Canadian Radiation Oncology Resident Survey  

SciTech Connect

Purpose: Statistics from the Canadian post-MD education registry show that numbers of Canadian radiation oncology (RO) trainees have risen from 62 in 1999 to approximately 150 per year between 2003 and 2009, contributing to the current perceived downturn in employment opportunities for radiation oncologists in Canada. When last surveyed in 2003, Canadian RO residents identified job availability as their main concern. Our objective was to survey current Canadian RO residents on their training and career plans. Methods and Materials: Trainees from the 13 Canadian residency programs using the national matching service were sought. Potential respondents were identified through individual program directors or chief resident and were e-mailed a secure link to an online survey. Descriptive statistics were used to report responses. Results: The eligible response rate was 53% (83/156). Similar to the 2003 survey, respondents generally expressed high satisfaction with their programs and specialty. The most frequently expressed perceived weakness in their training differed from 2003, with 46.5% of current respondents feeling unprepared to enter the job market. 72% plan on pursuing a postresidency fellowship. Most respondents intend to practice in Canada. Fewer than 20% of respondents believe that there is a strong demand for radiation oncologists in Canada. Conclusions: Respondents to the current survey expressed significant satisfaction with their career choice and training program. However, differences exist compared with the 2003 survey, including the current perceived lack of demand for radiation oncologists in Canada.

Debenham, Brock, E-mail: debenham@ualberta.net [Department of Radiation Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta (Canada); Banerjee, Robyn [Department of Radiation Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta (Canada); Fairchild, Alysa; Dundas, George [Department of Radiation Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta (Canada); Trotter, Theresa [Department of Radiation Oncology, Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta (Canada); Yee, Don [Department of Radiation Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta (Canada)

2012-03-15T23:59:59.000Z

473

Composition for radiation shielding  

DOE Patents (OSTI)

A composition for use as a radiation shield. The shield has a depleted urum core for absorbing gamma rays and a bismuth coating for preventing chemical corrosion and absorbing gamma rays. Alternatively, a sheet of gadolinium may be positioned between the uranium core and the bismuth coating for absorbing neutrons. The composition is preferably in the form of a container for storing materials that emit radiation such as gamma rays and neutrons. The container is preferably formed by casting bismuth around a pre-formed uranium container having a gadolinium sheeting, and allowing the bismuth to cool. The resulting container is a structurally sound, corrosion-resistant, radiation-absorbing container.

Kronberg, James W. (Aiken, SC)

1994-01-01T23:59:59.000Z

474

The Intense Radiation Gas  

E-Print Network (OSTI)

We present a new dispersion relation for photons that are nonlinearly interacting with a radiation gas of arbitrary intensity due to photon-photon scattering. It is found that the photon phase velocity decreases with increasing radiation intensity, it and attains a minimum value in the limit of super-intense fields. By using Hamilton's ray equations, a self-consistent kinetic theory for interacting photons is formulated. The interaction between an electromagnetic pulse and the radiation gas is shown to produce pulse self-compression and nonlinear saturation. Implications of our new results are discussed.

M. Marklund; P. K. Shukla; B. Eliasson

2004-10-14T23:59:59.000Z

475

METHOD FOR MEASURING RADIATION  

DOE Patents (OSTI)

A method for measuring an unknown integrated quantity of radiation with a condenser ionization chamber is described. The chamber is initially charged to a predetermined voltage by a voltage source. The chamber is then removed from the source and exposed to an unknown quantity of radiation for a period of time. The quantity of radiation to which the chamber was exposed is then measured by detecting the magnitude of the pulse of current necessary to recharge the chamber of its initial value through a suitable impedance. The current pulse is amplified and measured directly by a suitable pulse height analyzing system. (AEC)

Roesch, W.C.; McCall, R.C.

1961-11-21T23:59:59.000Z

476

Miniaturized radiation chirper  

SciTech Connect

The disclosure relates to a miniaturized radiation chirper for use with a small battery supplying on the order of 5 volts. A poor quality CdTe crystal which is not necessarily suitable for high resolution gamma ray spectroscopy is incorporated with appropriate electronics so that the chirper emits an audible noise at a rate that is proportional to radiation exposure level. The chirper is intended to serve as a personnel radiation warning device that utilizes new and novel electronics with a novel detector, a CdTe crystal. The resultant device is much smaller and has much longer battery life than existing chirpers.

Umbarger, C. John (Los Alamos, NM); Wolf, Michael A. (Los Alamos, NM)

1980-01-01T23:59:59.000Z

477

Adaptable methodology for automation application development  

Science Conference Proceedings (OSTI)

An adaptable methodology for automation application development (AMAAD) is introduced. This development methodology is based on the key concept that design automation (DA) applications are a subset of higher level knowledge-based engineering (KBE) applications, ... Keywords: CommonKADS, Design automation, Knowledge-based engineering, MOKA, Productivity enhancement

Christian van der Velden; Cees Bil; Xinghuo Xu

2012-04-01T23:59:59.000Z

478

Adaptive Battery Charge Scheduling with Bursty Workloads  

E-Print Network (OSTI)

1 Adaptive Battery Charge Scheduling with Bursty Workloads Dylan Lexie , Shan Lin, and Jie Wu.wu@temple.edu Abstract--Battery-powered wireless sensor devices need to be charged to provide the desired functionality after deployment. Task or even device failures can occur if the voltage of the battery is low

Wu, Jie

479

EMMA: an adaptive display for virtual therapy  

Science Conference Proceedings (OSTI)

Environments used up to now for therapeutic applications are invariable ones. Their contents can not be changed neither by the therapist nor by the patient. However, this is a technical issue that can be solved with current technology. In this paper, ... Keywords: adaptive display, virtual reality, virtual therapy

Mariano Alcaiz; Cristina Botella; Beatriz Rey; Rosa Baos; Jose A. Lozano; Nuria Lasso de la Vega; Diana Castilla; Javier Montesa; Antonio Hospitaler

2007-07-01T23:59:59.000Z

480

Modling and implementing adaptative pedagogical hyper documents  

Science Conference Proceedings (OSTI)

Today, a large number of interactive systems are developed thanks to hypermedia documents particularly in the education field. Due to the lack of experience feedback, it is always necessary to carry out reflections on the architecture of these systems ... Keywords: HCI, XML, adaptative hypermedia, e-learning

Sofiane Benadi; Patrick Prvot; Jean-Yves Ramel

2003-11-01T23:59:59.000Z

Note: This page contains sample records for the topic "radiation adaptive responses" from the National Library of EnergyBeta (NLEBeta).
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481

Efficient adaptive meshing of parametric models  

Science Conference Proceedings (OSTI)

Parametric modeling is becoming the representation of choice for most modern solid modelers. However, when generating the finite-element mesh of the model for simulation and analysis, most meshing tools ignore the parametric information and use only ... Keywords: adaptivity, mesh generation, parametric models

Alla Sheffer; Alper ngr

2001-05-01T23:59:59.000Z

482

A framework for adaptive execution in grids  

Science Conference Proceedings (OSTI)

Grids offer a dramatic increase in the number of available processing and storing resources that can be delivered to applications. However, efficient job submission and management continue being far from accessible to ordinary scientists and engineers ... Keywords: Globus, adaptive execution, grid technology, job migration

Eduardo Huedo; Ruben S. Montero; Ignacio M. Llorente

2004-06-01T23:59:59.000Z

483

Adaptive context reasoning in pervasive systems  

Science Conference Proceedings (OSTI)

It is hard to believe that the internet is now in its adolescent stage. Our information age is replete with communication capable, intelligent, sensor equipped devices. Social networks, web services, and global information repositories make a wealth ... Keywords: context, context inference, context middleware adaptation, context quality, context reasoning, information quality, quality aggregation, quality propagation

Bridget Beamon; Mohan Kumar

2010-11-01T23:59:59.000Z

484

Robust adaptive beamforming via target tracking  

Science Conference Proceedings (OSTI)

The proposed robust beamformer adaptively self-corrects and tracks desired-source location errors or variations regardless of the eigenstructure of the input correlation matrix, of the array shape and nature of the noise. It only requires an order of ...

S. Gazor; S. Affes; Y. Grenier

1996-06-01T23:59:59.000Z

485

STAPL: standard template adaptive parallel library  

Science Conference Proceedings (OSTI)

The Standard Template Adaptive Parallel Library (stapl) is a high-productivity parallel programming framework that extends C++ and stl with unified support for shared and distributed memory parallelism. stapl provides distributed data structures (pContainers) ... Keywords: high productivity parallel programming, library, parallel data structures

Antal Buss; Harshvardhan; Ioannis Papadopoulos; Olga Pearce; Timmie Smith; Gabriel Tanase; Nathan Thomas; Xiabing Xu; Mauro Bianco; Nancy M. Amato; Lawrence Rauchwerger

2010-05-01T23:59:59.000Z

486

Compact upwind schemes on adaptive octrees  

Science Conference Proceedings (OSTI)

Compact high-order upwind schemes using reconstruction from cell-averages are derived for application with the compressible three-dimensional Navier-Stokes equations. An adaptive-octree mesh, combined with the Adams-Bashforth-Moulton family of predictor-corrector ... Keywords: Finite-volume, High-order, Navier-Stokes, Predictor-corrector

Scott M. Murman

2010-02-01T23:59:59.000Z

487

Origin of Mutations Under Selection: The Adaptive  

E-Print Network (OSTI)

Origin of Mutations Under Selection: The Adaptive Mutation Controversy John R. Roth,1 Elisabeth 2006 by Annual Reviews. All rights reserved 0066-4227/06/1013-0477$20.00 Key Words natural selection Growth under selection causes new genotypes to predominate in a population. It is difficult to determine

California at Davis, University of

488

Dynamic repartitioning of adaptively refined meshes  

Science Conference Proceedings (OSTI)

One ingredient which is viewed as vital to the successful conduct of many large-scale numerical simulations is the ability to dynamically repartition the underlying adaptive finite element mesh among the processors so that the computations are balanced ... Keywords: multilevel diffusion, multilevel graph repartitioning, scratch-remap, wavefront diffusion

Kirk Schloegel; George Karypis; Vipin Kumar

1998-11-01T23:59:59.000Z