National Library of Energy BETA

Sample records for overseas assignment human

  1. Handbook on Overseas Assignments

    Broader source: Energy.gov [DOE]

    This handbook covers all types of Federal employment overseas, including details, both within DOE as well as to other agencies; transfers to approved international organizations; assignments to permanent DOE positions; cost-free experts; and personal services agreements (PSAs). This handbook contains information, guidance, sample service agreements, and related documentation that are to be used to implement the departments directives.

  2. Overseas Assignments | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    This handbook covers all types of Federal employment overseas, including details, both within DOE as well as to other agencies; transfers to approved international organizations; ...

  3. Overseas Corps Training Manual

    Office of Energy Efficiency and Renewable Energy (EERE)

    Purpose of Training Program under this Agreement - The Department of Energy provides workforce resources to support the Department’s mission and strategic plan objectives and requirements in overseas assignments.

  4. A Bayesian method for using simulator data to enhance human error probabilities assigned by existing HRA methods

    SciTech Connect (OSTI)

    Katrinia M. Groth; Curtis L. Smith; Laura P. Swiler

    2014-08-01

    In the past several years, several international organizations have begun to collect data on human performance in nuclear power plant simulators. The data collected provide a valuable opportunity to improve human reliability analysis (HRA), but these improvements will not be realized without implementation of Bayesian methods. Bayesian methods are widely used to incorporate sparse data into models in many parts of probabilistic risk assessment (PRA), but Bayesian methods have not been adopted by the HRA community. In this paper, we provide a Bayesian methodology to formally use simulator data to refine the human error probabilities (HEPs) assigned by existing HRA methods. We demonstrate the methodology with a case study, wherein we use simulator data from the Halden Reactor Project to update the probability assignments from the SPAR-H method. The case study demonstrates the ability to use performance data, even sparse data, to improve existing HRA methods. Furthermore, this paper also serves as a demonstration of the value of Bayesian methods to improve the technical basis of HRA.

  5. A Bayesian method for using simulator data to enhance human error probabilities assigned by existing HRA methods

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Groth, Katrina M.; Smith, Curtis L.; Swiler, Laura P.

    2014-04-05

    In the past several years, several international agencies have begun to collect data on human performance in nuclear power plant simulators [1]. This data provides a valuable opportunity to improve human reliability analysis (HRA), but there improvements will not be realized without implementation of Bayesian methods. Bayesian methods are widely used in to incorporate sparse data into models in many parts of probabilistic risk assessment (PRA), but Bayesian methods have not been adopted by the HRA community. In this article, we provide a Bayesian methodology to formally use simulator data to refine the human error probabilities (HEPs) assigned by existingmore » HRA methods. We demonstrate the methodology with a case study, wherein we use simulator data from the Halden Reactor Project to update the probability assignments from the SPAR-H method. The case study demonstrates the ability to use performance data, even sparse data, to improve existing HRA methods. Furthermore, this paper also serves as a demonstration of the value of Bayesian methods to improve the technical basis of HRA.« less

  6. Overseas shipments of 48Y cylinders

    SciTech Connect (OSTI)

    Tanaka, R.T.; Furlan, A.S.

    1991-12-31

    This paper describes experiences with two incidents of overseas shipments of uranium hexafluoride (UF{sub 6}) cylinders. The first incident involved nine empty UF{sub 6} cylinders in enclosed sea containers. Three UF{sub 6} cylinders broke free from their tie-downs and damaged and contaminated several sea containers. This paper describes briefly how decontamination was carried out. The second incident involved a shipment of 14 full UF{sub 6} cylinders. Although the incident did not cause an accident, the potential hazard was significant. The investigation of the cause of the near accident is recounted. Recommendations to alleviate future similar incidents for both cases are presented.

  7. Management and Funding of the Department's Overseas Presence

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2016-01-11

    The Order delineates DOE and NNSA requirements and responsibilities governing DOE's Overseas Presence in order to effectively implement U.S. national security objectives concerning energy security, nuclear security, and scientific discovery and innovation overseas through the presence of qualified DOE employees and contractors.

  8. Management and Funding of the Department's Overseas Presence

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2015-03-25

    This Order delineates DOE, including NNSA, requirements and responsibilities governing DOE's Overseas Presence in order to effectively meet national security objectives, including energy security, nuclear security, and scientific discovery and innovation, implemented outside the United States.

  9. Management and Funding of the Department's Overseas Presence

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-10-06

    This Notice establishes Department of Energy (DOE) and National Nuclear Security Administration requirements and responsibilities governing DOE's Overseas Presence in order to effectively meet national security objectives implemented outside the United States.

  10. Checklist for Medical Issues When Traveling Overseas | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Benefits » Wellness Programs » Foreign Travel Health & Wellness Information » Checklist for Medical Issues When Traveling Overseas Checklist for Medical Issues When Traveling Overseas Before the Trip A written confirmation from an appropriate manager, i.e., a Travel Authorization or memorandum, that identifies the employee and country(ies) that will be visited should be provided the medical support staff 4-8 weeks prior to the trip or, if less than 4 weeks, as soon as management or the

  11. Intergovernmental Personnel Act Assignments

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-08-24

    This Manual implements provisions of the Intergovernmental Personnel Act (IPA) within the Department of Energy (DOE) and establishes requirements, responsibilities, and authority for effecting assignments under the Act. Does not cancel other directives.

  12. Management and Funding of the Department's Overseas Presence

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2009-11-19

    This Order establishes Department of Energy (DOE), including the National Nuclear Security Administration, requirements and responsibilities governing DOE's Overseas Presence in order to effectively meet national security objectives, including energy security, nuclear security, and scientific discovery and innovation, implemented outside the United States. Does not cancel other directives.

  13. Notice of Intent to Revise DOE O 313.1, Management and Funding of the Department's Overseas Presence

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    In fiscal year 2014 the Department moved to funding the overseas presence via the Working Capital Fund (WCF) from the earlier, ad hoc, individual program office contribution schema. This new WCF approach needs to be reflected in the Order, as well as several administrative changes related to lessons-learned from managing the overseas presence via the Overseas Presence Advisory Board (OPAB).

  14. Notice of Intent to Revise DOE O 313.1, Management and Funding of the Departments Overseas Presence

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2015-11-06

    In fiscal year 2014 the Department moved to funding the overseas presence via the Working Capital Fund (WCF) from the earlier, ad hoc, individual program office contribution schema. This new WCF approach needs to be reflected in the Order, as well as several administrative changes related to lessons-learned from managing the overseas presence via the Overseas Presence Advisory Board (OPAB)

  15. Notice of Intent to Revise DOE O 313.1, Management and Funding of the Department's Overseas Presence

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2015-11-06

    In fiscal year 2014 the Department moved to funding the overseas presence via the Working Capital Fund (WCF) from the earlier, ad hoc, individual program office contribution schema. This new WCF approach needs to be reflected in the Order, as well as several administrative changes related to lessons-learned from managing the overseas presence via the Overseas Presence Advisory Board (OPAB)

  16. Program Assignments | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Services » Procurement Services » Program Assignments Program Assignments Office of Headquarters Procurement Services (MA-64) Program Assignments Mark C. Brady, Director,(202) 287-1389 Patricia Davies, Deputy Director, (202) 586-8975 CORPORATE SERVICES OFFICE - Anthony E. Cicala, Director, MA-64.1, (202) 586-7637 Strategic Initiatives Coordinator Competition Advocate Contracting Activity Task/Delivery Order Ombudsman Policy Flashes Independent Review Deborah Black - (202) 287-1416 Balanced

  17. Unclassified Foreign Visits and Assignments

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2004-06-18

    To define a program for unclassified foreign national access to Department of Energy sites, information, and technologies. This Order cancels DOE P 142.1, Unclassified Foreign Visits and Assignments, dated 7-14-99; DOE N 142.1, Unclassified Foreign Visits and Assignments, dated 7-14-99; Secretarial Memorandum Unclassified Foreign Visits and Assignments, dated 7-14-99; Memorandum from Francis S. Blake, Departmental Use of Foreign Access Central Tracking System, dated 11-05-01; Memorandum from Kyle E. McSlarrow, Interim Guidance for Implementation of the Department's Unclassified Foreign Visits and Assignments Program, dated 12-17-02; and Secretarial Memorandum, Policy Exclusion for Unclassified Foreign National's Access to Department of Energy Facilities in Urgent or Emergency Medical Situations, dated 4-10-01. Cancels: DOE P 142.1 and DOE N 142.1

  18. Unclassified Foreign Visits and Assignments

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-14

    To provide interim Department of Energy (DOE) requirements and responsibilities for unclassified visits and assignment by foreign nationals to DOE facilities for unclassified activities. This Notice supplements DOE P 142.1 dated 7-14-99, which sets overall Departmental policy on unclassified foreign visits and assignments. It is a complement to existing counterintelligence and security orders and policies. DOE N 251.53, dated 05/14/03, extends this directive until canceled. Cancels: DOE 1240.2B

  19. Ligncellulosic feedstock supply systems with intermodal and overseas transportation

    SciTech Connect (OSTI)

    Ric Hoefnagels; Kara Cafferty; Erin Searcy; Jacob J. Jacobson; Martin Junginger; Thijs Cornelissen; Andre Faaij

    2014-12-01

    With growing demand for biomass from industrial uses and international trade, the logistic operations required to economically move the biomass from the field or forest to the end users have become increasingly complex. In addition to economics, understanding energy and GHG emissions is required to design cost effective, sustainable logistic process operations; in order to improve international supply chains it is also important to understate their interdependencies and related uncertainties. This article presents an approach to assess lignocellulosic feedstock supply systems at the operational level. For this purpose, the Biomass Logistic Model (BLM) has been linked with the Geographic Information Systems based Biomass Intermodal Transportation model (BIT-UU) and extended with inter-continental transport routes. Case studies of herbaceous and woody biomass, produced in the U.S. Midwest and U.S. Southeast, respectively, and shipped to Europe for conversion to Fischer-Tropsch (FT) diesel are included to demonstrate how intermodal transportation and, in particular, overseas shipping integrates with the bioenergy supply chains. For the cases demonstrated, biomass can be supplied at 99 € Mg-1 to 117 € Mg-1 (dry) and converted to FT-diesel at 19 € GJ-1 to 24 € GJ-1 depending on the feedstock type and location, intermediate (chips or pellets) and size of the FT-diesel production plant. With the flexibility to change the design of supply chains as well as input variables, many alternative supply chain cases can be assessed.

  20. Unclassified Foreign Visits and Assignments

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-14

    International cooperation and collaboration is an important element in the effective planning and implementation of many Department of Energy (DOE) programs. DOE and its international partners benefit from the exchange of information that results from a managed process of unclassified visits and assignments by foreign nationals. These visits and assignments must be conducted in a manner consistent with U.S. and DOE national security policies, requirements, and objectives including export control laws and regulations. Canceled by DOE O 142.3. Does not cancel other directives.

  1. Foreign National Visit/Assignment Questionnaire

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Unclassified Foreign National Visits & Assignments Questionnaire Welcome to Department of Energy, Headquarters We are looking forward to your visit or assignment with us. In ...

  2. Unclassified Foreign National Visits & Assignments Questionnaire |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Services » Calibration Facilities » Unclassified Foreign National Visits & Assignments Questionnaire Unclassified Foreign National Visits & Assignments Questionnaire Visitors who are foreign nationals must complete and submit the Unclassified Foreign National Visits & Assignments Questionnaire 30 days before accessing facilities. Unclassified Foreign National Visits & Assignments Questionnaire (192.5 KB) More Documents & Publications HQ FNVA

  3. Draft - DOE O 313.1A, Management and Funding of the Departments Overseas Presence

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    The Order delineates DOE and NNSA requirements and responsibilities governing DOE's Overseas Presence in order to effectively implement U.S. national security objectives concerning energy security, nuclear security, and scientific discovery and innovation overseas through the presence of qualified DOE employees and contractors.

  4. Recruitment and Hiring | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    They will clarify the use of the authority and assist managers, supervisors, and human ... Compensation EmploymentStaffing Recruitment Hiring Overseas Assignment Human Capital ...

  5. DRAFT - DOE O 313.1A, Management and Funding of the Departments Overseas Presence

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    This Order delineates DOE, including NNSA, requirements and responsibilities governing DOEs Overseas Presence in order to effectively meet national security objectives, including energy security, nuclear security, and scientific discovery and innovation, implemented outside the United States.

  6. Preparing for Project Implementation Assigning Accountability...

    Broader source: Energy.gov (indexed) [DOE]

    Assigning Accountability for Each Project (April 14, 2010) (598.01 KB) More Documents & Publications Preparing for Project Implementation after an Energy Assessment

  7. JOBAID-LAUNCHING AND COMPLETING ASSIGNED SURVEY

    Broader source: Energy.gov [DOE]

    The purpose of this job aid is to guide users through the step-by-step process of launching and completing assigned surverys.

  8. Foreign National Visit/Assignment Questionnaire

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Information (PII) Company Proprietary Information ... areas are to be visited) Property Protection Area with ... and Assignments 47 Is an Export Control License Required? ...

  9. Continuous Learning Points Credit Assignment Table | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    PDF icon Microsoft Word - CLPCreditAssignmentTable More Documents & Publications PMCDP Curriculum Learning Map Microsoft Word - AL2006-07.doc PMCDP Certification and Equivalency ...

  10. Organizations' Assignment of Responsibility - DOE Directives,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Delegations, and Requirements Organizations' Assignment of Responsibility Current By Functional Area By Position Designations Assignments Rescinded by Diane Johnson More filters Less filters Filters applied Δ Hide filters ∇ Show filters (0) [X] Remove all Issue Date Start date End date ffe8aa65e5ad705f837fe439ace37780

  11. JOBAID-SELF ASSIGNING COURSES (ITEMS)

    Broader source: Energy.gov [DOE]

    In this jobaid you will learn to use the Course Catalog, Browse Catalog, Recommended Items, Locate and Self-Assign Items (Courses) Using the Search Catalog features, Narrow Course Searches using...

  12. Help:Assigning permissions | Open Energy Information

    Open Energy Info (EERE)

    search "Assigning permissions" means granting users extra rights within the wiki software (or revoking these rights). This is done by going to the Special:UserRights page, and...

  13. Unclassified Foreign National Visits & Assignments Questionnaire

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Unclassified Foreign National Visits & Assignments Questionnaire |Welcome to U.S. Department of Energy Office of Legacy Management! We are looking forward to your visit or assignment with us. In order to comply with our security requirements and ensure that your time with the Department of Energy goes smoothly we need to obtain some information from you prior to your arrival. Please take a few minutes to provide the information requested below for each member of your party that is not a U.S.

  14. Unclassified Foreign Visits and Assignments Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2004-06-18

    The order defines a program for unclassified foreign national access to Department of Energy sites, information, and technologies. The page change streamlines the HQs Management Panel review process to include reviews by HSS, IN, and a representative of the cognizant under secretary for access requests involving foreign nationals. Cancels Secretarial Memorandum, Unclassified Foreign Visits and Assignments, dated 7-14-99; Memorandum from Francis S. Blake, Departmental Use of Foreign Access Central Tracking System, dated 11-05-01; Memorandum from Kyle E. McSlarrow, Interim Guidance for Implementation of the Department's Unclassified Foreign Visits and Assignments Program, dated 12-17-02; and Secretarial Memorandum, Policy Exclusion for Unclassified Foreign National's Access to Department of Energy Facilities in Urgent or Emergency Medical Situations, dated 4-10-01. Cancels: DOE P 142.1 and DOE N 142.1

  15. NREL Researcher on Assignment in South Africa

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    on Assignment in South Africa For more information contact: e:mail: Public Affairs Golden, Colo., Oct. 20, 1997 -- A policy analyst with the U.S. Department of Energy's (DOE) National Renewable Energy Laboratory (NREL) is headed to South Africa for eight months of high-level economic research on the South African electricity supply industry. Principal Analyst Paul Galen in NREL's Center for Energy Analysis and Applications will be a visiting researcher with the South African Minerals and Energy

  16. Unclassified Foreign National Visits and Assignments

    Broader source: Energy.gov [DOE]

    Attached for your information is a March 9,201 0 Memorandum from the Deputy Secretary relaxing certain check and approval requirements relating to visits and assignments of foreign nationals to DOE facilities and National Laboratories, including National Nuclear Security Administration sites. This is part of an ongoing review of DOE Order 142.3. Please furnish a copy to affected contractors pending revision of the Order and its associated Contractor Requirements Document.

  17. Project Registration Number Assignments (Active) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Active) Project Registration Number Assignments (Active) As of: May 2016 Provides a table of Project Registration Number Assignments (Active) Project Registration Number Assignment (Active) (511.76 KB) More Documents & Publications All Active DOE Technical Standards Document Project Registration Number Assignments (Completed

  18. Project Registration Number Assignments (Completed) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Completed) Project Registration Number Assignments (Completed) As of: May 2016 Provides a table of Project Registration Number Assignments (Completed) Project Registration Number Assignments (Completed) (406.85 KB) More Documents & Publications All Active DOE Technical Standards Document Project Registration Number Assignments (Active

  19. Parameter Assignments for Spectral Gamma-Ray Borehole Calibration Models

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    (April 1984) | Department of Energy Parameter Assignments for Spectral Gamma-Ray Borehole Calibration Models (April 1984) Parameter Assignments for Spectral Gamma-Ray Borehole Calibration Models (April 1984) Parameter Assignments for Spectral Gamma-Ray Borehole Calibration Models (April 1984) Parameter Assignments for Spectral Gamma-Ray Borehole Calibration Models (April 1984) (3.25 MB) More Documents & Publications Grade Assignments for Models Used for Calibration of Gross-Count

  20. Calibration Pad Assignments for Spectral Gamma (November 1985) | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy Pad Assignments for Spectral Gamma (November 1985) Calibration Pad Assignments for Spectral Gamma (November 1985) Calibration Pad Assignments for Spectral Gamma (November 1985) Calibration Pad Assignments for Spectral Gamma (November 1985) (5.3 MB) More Documents & Publications Parameter Assignments for Spectral Gamma-Ray Borehole Calibration Models (April 1984) Field Calibration Facilities for Environmental Measurement of Radium, Thorium, and Potassium (October 2013) Grade

  1. 3210T3 Risk Code Assignment;

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    210 Appendix T3 Risk Code Assignment 1.0 Purpose Identification of work hazards and understanding their risks is an essential part of Jefferson Lab's work process as defined in ES&H Manual Chapter 3210 Appendix T1 Work Planning, Control, and Authorization Procedure. The purpose of this document is to demonstrate the accepted method for determining the Risk Code for task steps identified while completing Task Hazard Analysis (THA) Worksheet. 2.0 Scope This appendix describes the procedure for

  2. Foreign Visits & Assignments Guidelines | The Ames Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Foreign Visits & Assignments Guidelines Foreign Visits and Assignments Requests (473's) and Specific Security Plans Please use the following links to reach Form 473, the Foreign Visits and Assignments Request Form, as well as the Ames Laboratory Specific Security Plan Form. Form 473 Foreign Visits and Assignments Request Form Specific Security Plan Program Overview. The USDOE considers hosting foreign visitors a critical responsibility. This is especially true when the foreign national is

  3. Recognizing and Assigning ESPC Risks and Responsibilities Using the Risk,

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Responsibility, and Performance Matrix | Department of Energy Recognizing and Assigning ESPC Risks and Responsibilities Using the Risk, Responsibility, and Performance Matrix Recognizing and Assigning ESPC Risks and Responsibilities Using the Risk, Responsibility, and Performance Matrix Document offers guidance on how to recognize and assign energy savings performance contract (ESPC) risks and responsibilities using the risk, responsibility, and performance matrix, also known as RRPM.

  4. Recognizing and Assigning ESPC Risks and Responsibilities Using...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Using the Risk, Responsibility, and Performance Matrix Recognizing and Assigning ESPC Risks and Responsibilities Using the Risk, Responsibility, and Performance Matrix ...

  5. Chief of Nuclear Safety (CNS) Staff Assignments & Expertise ...

    Broader source: Energy.gov (indexed) [DOE]

    Chief of Nuclear Safety (CNS) Staff Assignments & Expertise CNS staff maintains adequate technical proficiency, including the timely completion of Senior Technical Safety Manager...

  6. FOAM (Functional Ontology Assignments for Metagenomes): A Hidden...

    Office of Scientific and Technical Information (OSTI)

    Ontology Assignments for Metagenomes): A Hidden Markov Model (HMM) database with environmental focus Citation Details In-Document Search Title: FOAM (Functional Ontology...

  7. Measuring the maturity of a technology : guidance on assigning...

    Office of Scientific and Technical Information (OSTI)

    Technical Report: Measuring the maturity of a technology : guidance on assigning a TRL. ... for supplier-customer interactions at a very early stage in technology development. ...

  8. Acquisition Letter on Contractor Domestic Extended Personnel Assignments

    Broader source: Energy.gov [DOE]

    The attached Acquisition Letter has been issued to provide guidance on the Department's policy governing reimbursement of costs associated with contractor domestic extended personnel assignments.

  9. NNSA authorizes mission assignment transfer to Kansas City Plant | National

    National Nuclear Security Administration (NNSA)

    Nuclear Security Administration | (NNSA) authorizes mission assignment transfer to Kansas City Plant Wednesday, June 25, 2014 - 1:05pm To improve efficiency across the nuclear security enterprise, NNSA recently transferred the mission assignment of several product families from Sandia National Laboratories to the Kansas City Plant. The mission reassignment better aligns responsibilities with each site's core competencies and will leverage Kansas City's Supply Chain Management systems and

  10. EPRI/NRC-RES fire human reliability analysis guidelines.

    SciTech Connect (OSTI)

    Lewis, Stuart R.; Cooper, Susan E.; Najafi, Bijan; Collins, Erin; Hannaman, Bill; Kohlhepp, Kaydee; Grobbelaar, Jan; Hill, Kendra; Hendrickson, Stacey M. Langfitt; Forester, John Alan; Julius, Jeff

    2010-03-01

    During the 1990s, the Electric Power Research Institute (EPRI) developed methods for fire risk analysis to support its utility members in the preparation of responses to Generic Letter 88-20, Supplement 4, 'Individual Plant Examination - External Events' (IPEEE). This effort produced a Fire Risk Assessment methodology for operations at power that was used by the majority of U.S. nuclear power plants (NPPs) in support of the IPEEE program and several NPPs overseas. Although these methods were acceptable for accomplishing the objectives of the IPEEE, EPRI and the U.S. Nuclear Regulatory Commission (NRC) recognized that they required upgrades to support current requirements for risk-informed, performance-based (RI/PB) applications. In 2001, EPRI and the USNRC's Office of Nuclear Regulatory Research (RES) embarked on a cooperative project to improve the state-of-the-art in fire risk assessment to support a new risk-informed environment in fire protection. This project produced a consensus document, NUREG/CR-6850 (EPRI 1011989), entitled 'Fire PRA Methodology for Nuclear Power Facilities' which addressed fire risk for at power operations. NUREG/CR-6850 developed high level guidance on the process for identification and inclusion of human failure events (HFEs) into the fire PRA (FPRA), and a methodology for assigning quantitative screening values to these HFEs. It outlined the initial considerations of performance shaping factors (PSFs) and related fire effects that may need to be addressed in developing best-estimate human error probabilities (HEPs). However, NUREG/CR-6850 did not describe a methodology to develop best-estimate HEPs given the PSFs and the fire-related effects. In 2007, EPRI and RES embarked on another cooperative project to develop explicit guidance for estimating HEPs for human failure events under fire generated conditions, building upon existing human reliability analysis (HRA) methods. This document provides a methodology and guidance for conducting

  11. Statistical methods of spin assignment in compound nuclear reactions

    SciTech Connect (OSTI)

    Mach, H.; Johns, M.W.

    1985-01-15

    Spin assignment to nuclear levels can be obtained from standard in-beam gamma-ray spectroscopy techniques and in the case of compound nuclear reactions can be complemented by statistical methods. These are based on a correlation pattern between level spin and gamma-ray intensities feeding low-lying levels. Three types of intensity and level spin correlations are found suitable for spin assignment: shapes of the excitation functions, ratio of intensity at two beam energies or populated in two different reactions, and feeding distributions. Various empirical attempts are examined and the range of applicability of these methods as well as the limitations associated with them are given.

  12. Electric Utility Company Assigned to a Zip Code? | OpenEI Community

    Open Energy Info (EERE)

    Electric Utility Company Assigned to a Zip Code? Home I have found an error in the utility company assigned to a zip code. I am not sure if the "assigned" utility company covers...

  13. Method for assigning sites to projected generic nuclear power plants

    SciTech Connect (OSTI)

    Holter, G.M.; Purcell, W.L.; Shutz, M.E.; Young, J.R.

    1986-07-01

    Pacific Northwest Laboratory developed a method for forecasting potential locations and startup sequences of nuclear power plants that will be required in the future but have not yet been specifically identified by electric utilities. Use of the method results in numerical ratings for potential nuclear power plant sites located in each of the 10 federal energy regions. The rating for each potential site is obtained from numerical factors assigned to each of 5 primary siting characteristics: (1) cooling water availability, (2) site land area, (3) power transmission land area, (4) proximity to metropolitan areas, and (5) utility plans for the site. The sequence of plant startups in each federal energy region is obtained by use of the numerical ratings and the forecasts of generic nuclear power plant startups obtained from the EIA Middle Case electricity forecast. Sites are assigned to generic plants in chronological order according to startup date.

  14. 2210R1 ES&H Staff Assignments

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    210 Appendix R1 Staff Assigned to ES&H Activities 1.0 Purpose This appendix provides information for current Environmental, Safety and Health (ES&H) related staff positions at Jefferson Lab. Other positions of responsibility are outlined on the various Division & Department's Organization Charts. * Section 2.0 - Contact Information for Hazard Issues * Section 3.0 - Contact Information for Responsible Positions * Section 4.0 - Councils and Committees * Section 5.0 - Division Safety

  15. Automated Pre-processing for NMR Assignments with Reduced Tedium

    Energy Science and Technology Software Center (OSTI)

    2004-05-11

    An important rate-limiting step in the reasonance asignment process is accurate identification of resonance peaks in MNR spectra. NMR spectra are noisy. Hence, automatic peak-picking programs must navigate between the Scylla of reliable but incomplete picking, and the Charybdis of noisy but complete picking. Each of these extremes complicates the assignment process: incomplete peak-picking results in the loss of essential connectivities, while noisy picking conceals the true connectivities under a combinatiorial explosion of false positives.more » Intermediate processing can simplify the assignment process by preferentially removing false peaks from noisy peak lists. This is accomplished by requiring consensus between multiple NMR experiments, exploiting a priori information about NMR spectra, and drawing on empirical statistical distributions of chemical shift extracted from the BioMagResBank. Experienced NMR practitioners currently apply many of these techniques "by hand", which is tedious, and may appear arbitrary to the novice. To increase efficiency, we have created a systematic and automated approach to this process, known as APART. Automated pre-processing has three main advantages: reduced tedium, standardization, and pedagogy. In the hands of experienced spectroscopists, the main advantage is reduced tedium (a rapid increase in the ratio of true peaks to false peaks with minimal effort). When a project is passed from hand to hand, the main advantage is standardization. APART automatically documents the peak filtering process by archiving its original recommendations, the accompanying justifications, and whether a user accepted or overrode a given filtering recommendation. In the hands of a novice, this tool can reduce the stumbling block of learning to differentiate between real peaks and noise, by providing real-time examples of how such decisions are made.« less

  16. Assigning Seismic Design Category to Large Reactors: A Case Study of the ATR

    Broader source: Energy.gov [DOE]

    Assigning Seismic Design Category to Large Reactors: A Case Study of the ATR Stuart Jensen October 21, 2014

  17. Term Assignments of Contractors to the Washington D.C. Area.

    Broader source: Energy.gov [DOE]

    On July 2, 2013 the DOE Office of the Inspector General issued Audit Report Number 0890 entitled, "Follow-up Audit on Term Assignments of Contractor Employees." The audit was conducted as a follow-up of the FY 2005 audit of "Management of Facility Contractors Assigned to the Washington D.C. area DOE/IG 0710." The earlier report found instances where assignment justifications were insufficient, costs appeared excessive and allowances inconsistent. The follow-up audit recognized improved management of assignments but noted assignment justifications and cost management could be improved. The report recommended DOE determine prior year actual costs to assist in calculating the estimated costs for the upcoming year of multi-year assignments and ensure assignment records in the Departmental Management and Tracking System (DMATS) are accurate.

  18. Assignments of the Raman modes of monoclinic erbium oxide

    SciTech Connect (OSTI)

    Yan, D.; Wu, P. Zhang, S. P.; Liang, L.; Yang, F.; Pei, Y. L.; Chen, S.

    2013-11-21

    As a heavy rare earth oxide, erbium oxide (Er{sub 2}O{sub 3}) has many attractive properties. Monoclinic Er{sub 2}O{sub 3} has useful properties not found in stable cubic Er{sub 2}O{sub 3}, such as unique optical properties and high radiation damage tolerance. In this study, cubic Er{sub 2}O{sub 3} coating and Er{sub 2}O{sub 3} coating with mixed phases were prepared. The Raman scattering spectra of these coatings were investigated by using a confocal micro-Raman spectrometer equipped with 325, 473, 514, 532, 633, and 784 nm lasers. A total of 17 first-order Raman modes of monoclinic Er{sub 2}O{sub 3} were identified and assigned. The modes at 83, 112, 152, 170, 278, 290, 409, 446, 478, 521, 603, and 622 cm{sup −1} are of A{sub g} symmetry, whereas modes at 71, 98, 333, 409, 446, and 468 cm{sup −1} are of B{sub g} symmetry. This research provides basic data necessary for the characterization of monoclinic Er{sub 2}O{sub 3} by Raman spectroscopy.

  19. Chief of Nuclear Safety (CNS) Staff Assignments & Expertise | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Chief of Nuclear Safety (CNS) Staff Assignments & Expertise Chief of Nuclear Safety (CNS) Staff Assignments & Expertise Chief of Nuclear Safety (CNS) Staff Assignments & Expertise CNS staff maintains adequate technical proficiency, including the timely completion of Senior Technical Safety Manager (STSM) qualification. Further, CNS staff periodically review and assess whether EM is maintaining adequate numbers of technically competent personnel necessary to fulfill its

  20. Audit Report - Follow-up Audit on Term Assignments of Contractor...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    when compared to other means of acquiring the necessary knowledge and experience. Our 2005 report on Management of Facility Contractors Assigned to the Washington, DC Area ...

  1. Calibration Model Assignments expressed as U3O8, Summary Table ES-1 |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Model Assignments expressed as U3O8, Summary Table ES-1 Calibration Model Assignments expressed as U3O8, Summary Table ES-1 Calibration Model Assignments expressed as U3O8, Summary Table ES-1 Calibration Model Assignments expressed as U3O8, Summary Table ES-1 (25.9 KB) More Documents & Publications Field Calibration Facilities for Environmental Measurement of Radium, Thorium, and Potassium (October 2013) Offshore Wind Market and Economic Analysis Report 2013 Natural

  2. Parameter assignments for spectral gamma-ray borehole calibration models. National Uranium Resource Evaluation

    SciTech Connect (OSTI)

    Heistand, B.E.; Novak, E.F.

    1984-04-01

    This report documents the work performed to determine the newly assigned concentrations for the spectral gamma-ray borehole calibration models. Thirty-two models, maintained by the US Department of Energy, are included in this study, and are grouped into eight sets of four models each. The eight sets are located at sites across the United States, and are used to calibrate logging instruments. The assignments are based on in-situ logging data to ensure self-consistency in the assigned concentrations, and on laboratory assays of concrete samples from each model to provide traceability to the New Brunswick Laboratory (NBL) standards. 13 references, 7 figures, 17 tables.

  3. Unclassified Foreign National Visits and Assignments at Oak Ridge National Laboratory

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Unclassified Foreign National Visits and Assignments at Oak Ridge National Laboratory INS-O-13-05 September 2013 Department of Energy Washington, DC 20585 September 16, 2013 MEMORANDUM FOR THE MANAGER, OAK RIDGE NATIONAL LABORATORY SITE OFFICE FROM: Sandra D. Bruce Assistant Inspector General for Inspections Office of Inspector General SUBJECT: INFORMATION: Inspection Report on "Unclassified Foreign National Visits and Assignments at Oak Ridge National Laboratory" BACKGROUND In support

  4. GENERAL ASSIGNMENT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GEA Honors Geothermal Leaders GEA Honors Geothermal Leaders December 9, 2013 - 12:00am Addthis Washington, D.C. (December 9, 2013) The Geothermal Energy Association (GEA) has announced the winners for the GEA Honors, which recognize companies and individuals that have made significant contributions during the past year to advancing technology, spurring economic development and protecting the environment. The winners were selected in categories including Technological Advancement, Economic

  5. Method and system for assigning a confidence metric for automated determination of optic disc location

    DOE Patents [OSTI]

    Karnowski, Thomas P.; Tobin, Jr., Kenneth W.; Muthusamy Govindasamy, Vijaya Priya; Chaum, Edward

    2012-07-10

    A method for assigning a confidence metric for automated determination of optic disc location that includes analyzing a retinal image and determining at least two sets of coordinates locating an optic disc in the retinal image. The sets of coordinates can be determined using first and second image analysis techniques that are different from one another. An accuracy parameter can be calculated and compared to a primary risk cut-off value. A high confidence level can be assigned to the retinal image if the accuracy parameter is less than the primary risk cut-off value and a low confidence level can be assigned to the retinal image if the accuracy parameter is greater than the primary risk cut-off value. The primary risk cut-off value being selected to represent an acceptable risk of misdiagnosis of a disease having retinal manifestations by the automated technique.

  6. 1H, 13C, and 15N backbone and side chain resonance assignments of thermophilic Geobacillus kaustophilus cyclophilin-A

    SciTech Connect (OSTI)

    Holliday, Michael; Zhang, Fengli; Isern, Nancy G.; Armstrong, Geoffrey S.; Eisenmesser, Elan Z.

    2014-04-01

    Cyclophilins catalyze the reversible peptidyl-prolyl isomerization of their substrates and are present across all kingdoms of life from humans to bacteria. Although numerous biological roles have now been discovered for cyclophilins, their function was initially ascribed to their chaperone-like activity in protein folding where they catalyze the often rate-limiting step of proline isomerization. This chaperone-like activity may be especially important under extreme conditions where cyclophilins are often over expressed, such as in tumors for human cyclophilins {Lee, 2010 #1167}, but also in organisms that thrive under extreme conditions, such as theromophilic bacteria. Moreover, the reversible nature of the peptidyl-prolyl isomerization reaction catalyzed by cyclophilins has allowed these enzymes to serve as model systems for probing the role of conformational changes during catalytic turnover {Eisenmesser, 2002 #20;Eisenmesser, 2005 #203}. Thus, we present here the resonance assignments of a thermophilic cyclophilin from Geobacillus kaustophilus derived from deep-sea sediment {Takami, 2004 #1384}. This thermophilic cyclophilin may now be studied at a variety of temperatures to provide insight into the comparative structure, dynamics, and catalytic mechanism of cyclophilins.

  7. Balance Calibration A Method for Assigning a Direct-Reading Uncertainty to an Electronic Balance.

    SciTech Connect (OSTI)

    Mike Stears

    2010-07-01

    Paper Title: Balance Calibration A method for assigning a direct-reading uncertainty to an electronic balance. Intended Audience: Those who calibrate or use electronic balances. Abstract: As a calibration facility, we provide on-site (at the customers location) calibrations of electronic balances for customers within our company. In our experience, most of our customers are not using their balance as a comparator, but simply putting an unknown quantity on the balance and reading the displayed mass value. Manufacturers specifications for balances typically include specifications such as readability, repeatability, linearity, and sensitivity temperature drift, but what does this all mean when the balance user simply reads the displayed mass value and accepts the reading as the true value? This paper discusses a method for assigning a direct-reading uncertainty to a balance based upon the observed calibration data and the environment where the balance is being used. The method requires input from the customer regarding the environment where the balance is used and encourages discussion with the customer regarding sources of uncertainty and possible means for improvement; the calibration process becomes an educational opportunity for the balance user as well as calibration personnel. This paper will cover the uncertainty analysis applied to the calibration weights used for the field calibration of balances; the uncertainty is calculated over the range of environmental conditions typically encountered in the field and the resulting range of air density. The temperature stability in the area of the balance is discussed with the customer and the temperature range over which the balance calibration is valid is decided upon; the decision is based upon the uncertainty needs of the customer and the desired rigor in monitoring by the customer. Once the environmental limitations are decided, the calibration is performed and the measurement data is entered into a custom

  8. Manual of functions, assignments, and responsibilities for nuclear safety: Revision 2

    SciTech Connect (OSTI)

    Not Available

    1994-10-15

    The FAR Manual is a convenient easy-to-use collection of the functions, assignments, and responsibilities (FARs) of DOE nuclear safety personnel. Current DOE directives, including Orders, Secretary of Energy Notices, and other assorted policy memoranda, are the source of this information and form the basis of the FAR Manual. Today, the majority of FARs for DOE personnel are contained in DOE`s nuclear safety Orders. As these Orders are converted to rules in the Code of Federal Regulations, the FAR Manual will become the sole source for information relating to the functions, assignments, responsibilities of DOE nuclear safety personnel. The FAR Manual identifies DOE directives that relate to nuclear safety and the specific DOE personnel who are responsible for implementing them. The manual includes only FARs that have been extracted from active directives that have been approved in accordance with the procedures contained in DOE Order 1321.1B.

  9. DOE F 321.1 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    21.1 DOE F 321.1 Form is used to establish an agreement between the Department and an individual for positions overseas by specifying conditions under which services sre to be provided while located overseas and the benefits or entitlements DOE will provide. Service Agreement for an Overseas Position (16.98 KB) More Documents & Publications Handbook on Overseas Assignments Overseas Corps Training Manual NEUP Foreign Travel Request Form

  10. The role of high-level calculations in the assignment of the Q-band spectra of chlorophyll

    SciTech Connect (OSTI)

    Reimers, Jeffrey R.; Cai, Zheng-Li; Kobayashi, Rika; Rtsep, Margus; Freiberg, Arvi; Krausz, Elmars

    2014-10-06

    We recently established a novel assignment of the visible absorption spectrum of chlorophyll-a that sees the two components Q{sub x} and Q{sub y} of the low-energy Q band as being intrinsically mixed by non-adiabatic coupling. This ended 50 years debate as to the nature of the Q bands, with prior discussion poised only in the language of the Born-Oppenheimer and Condon approximations. The new assignment presents significant ramifications for exciton transport and quantum coherence effects in photosystems. Results from state of the art electronic structure calculations have always been used to justify assignments, but quantitative inaccuracies and systematic failures have historically limited usefulness. We examine the role of CAM-B3LYP time-dependent density-functional theory (TD-DFT) and Symmetry Adapted Cluster-Configuration Interaction (SAC-CI) calculations in first showing that all previous assignments were untenable, in justifying the new assignment, in making some extraordinary predictions that were vindicated by the new assignment, and in then identifying small but significant anomalies in the extensive experimental data record.

  11. FOAM (Functional Ontology Assignments for Metagenomes): A Hidden Markov Model (HMM) database with environmental focus

    SciTech Connect (OSTI)

    Prestat, Emmanuel; David, Maude M.; Hultman, Jenni; Ta , Neslihan; Lamendella, Regina; Dvornik, Jill; Mackelprang, Rachel; Myrold, David D.; Jumpponen, Ari; Tringe, Susannah G.; Holman, Elizabeth; Mavromatis, Konstantinos; Jansson, Janet K.

    2014-09-26

    A new functional gene database, FOAM (Functional Ontology Assignments for Metagenomes), was developed to screen environmental metagenomic sequence datasets. FOAM provides a new functional ontology dedicated to classify gene functions relevant to environmental microorganisms based on Hidden Markov Models (HMMs). Sets of aligned protein sequences (i.e. ‘profiles’) were tailored to a large group of target KEGG Orthologs (KOs) from which HMMs were trained. The alignments were checked and curated to make them specific to the targeted KO. Within this process, sequence profiles were enriched with the most abundant sequences available to maximize the yield of accurate classifier models. An associated functional ontology was built to describe the functional groups and hierarchy. FOAM allows the user to select the target search space before HMM-based comparison steps and to easily organize the results into different functional categories and subcategories. FOAM is publicly available at http://portal.nersc.gov/project/m1317/FOAM/.

  12. Infrared and Raman spectra, DFT-calculations and spectral assignments of germacyclohexane

    SciTech Connect (OSTI)

    Aleksa, V. Ozerenskis, D.; Pucetaite, M.; Sablinskas, V.; Cotter, C.; Guirgis, G. A.

    2015-03-30

    Raman spectra of germacyclohexane in liquid and solid states were recorded and depolarization data obtained. Infrared absorption spectra of the vapor and liquid have been studied. The wavenumbers of the vibrational modes were derived in the harmonic and anharmonic approximation in B3LYP/ccpVTZ calculations. According to the calculations, germacyclohexane exists in the stable chair conformation, whereas a possible twist form should have more than 15 kJ·mol{sup -1} higher enthalpy of formation what makes this conformer experimentally not observable. The 27 A' and 21 A'' fundamentals were assigned on the basis of the calculations and infrared and Raman band intensities, contours of gas phase infrared spectral bands and Raman depolarization measurements. An average discrepancy of ca. 0.77 % was found between the observed and the calculated anharmonic wavenumbers for the 48 modes. Substitution of carbon atom with Ge atom in the cyclohexane ring is reasoning flattening of the ring.

  13. Quadratic partial eigenvalue assignment in large-scale stochastic dynamic systems for resilient and economic design

    SciTech Connect (OSTI)

    Das, Sonjoy; Goswami, Kundan; Datta, Biswa N.

    2014-12-10

    Failure of structural systems under dynamic loading can be prevented via active vibration control which shifts the damped natural frequencies of the systems away from the dominant range of loading spectrum. The damped natural frequencies and the dynamic load typically show significant variations in practice. A computationally efficient methodology based on quadratic partial eigenvalue assignment technique and optimization under uncertainty has been formulated in the present work that will rigorously account for these variations and result in an economic and resilient design of structures. A novel scheme based on hierarchical clustering and importance sampling is also developed in this work for accurate and efficient estimation of probability of failure to guarantee the desired resilience level of the designed system. Numerical examples are presented to illustrate the proposed methodology.

  14. Spatial assignment of symmetry adapted perturbation theory interaction energy components: The atomic SAPT partition

    SciTech Connect (OSTI)

    Parrish, Robert M.; Sherrill, C. David

    2014-07-28

    We develop a physically-motivated assignment of symmetry adapted perturbation theory for intermolecular interactions (SAPT) into atom-pairwise contributions (the A-SAPT partition). The basic precept of A-SAPT is that the many-body interaction energy components are computed normally under the formalism of SAPT, following which a spatially-localized two-body quasiparticle interaction is extracted from the many-body interaction terms. For electrostatics and induction source terms, the relevant quasiparticles are atoms, which are obtained in this work through the iterative stockholder analysis (ISA) procedure. For the exchange, induction response, and dispersion terms, the relevant quasiparticles are local occupied orbitals, which are obtained in this work through the Pipek-Mezey procedure. The local orbital atomic charges obtained from ISA additionally allow the terms involving local orbitals to be assigned in an atom-pairwise manner. Further summation over the atoms of one or the other monomer allows for a chemically intuitive visualization of the contribution of each atom and interaction component to the overall noncovalent interaction strength. Herein, we present the intuitive development and mathematical form for A-SAPT applied in the SAPT0 approximation (the A-SAPT0 partition). We also provide an efficient series of algorithms for the computation of the A-SAPT0 partition with essentially the same computational cost as the corresponding SAPT0 decomposition. We probe the sensitivity of the A-SAPT0 partition to the ISA grid and convergence parameter, orbital localization metric, and induction coupling treatment, and recommend a set of practical choices which closes the definition of the A-SAPT0 partition. We demonstrate the utility and computational tractability of the A-SAPT0 partition in the context of side-on cation-π interactions and the intercalation of DNA by proflavine. A-SAPT0 clearly shows the key processes in these complicated noncovalent interactions, in

  15. Human Resources | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources

  16. Assigning unique identification numbers to new user accounts and groups in a computing environment with multiple registries

    DOE Patents [OSTI]

    DeRobertis, Christopher V.; Lu, Yantian T.

    2010-02-23

    A method, system, and program storage device for creating a new user account or user group with a unique identification number in a computing environment having multiple user registries is provided. In response to receiving a command to create a new user account or user group, an operating system of a clustered computing environment automatically checks multiple registries configured for the operating system to determine whether a candidate identification number for the new user account or user group has been assigned already to one or more existing user accounts or groups, respectively. The operating system automatically assigns the candidate identification number to the new user account or user group created in a target user registry if the checking indicates that the candidate identification number has not been assigned already to any of the existing user accounts or user groups, respectively.

  17. Quantitative IR Spectrum and Vibrational Assignments for Glycolaldehyde Vapor: Glycolaldehyde Measurements in Biomass Burning Plumes

    SciTech Connect (OSTI)

    Johnson, Timothy J.; Sams, Robert L.; Profeta, Luisa T.; Akagi, Sheryl; Burling, Ian R.; Yokelson, Robert J.; Williams, Stephen D.

    2013-04-15

    Glycolaldehyde (GA, 2-hydroxyethanal, C2H4O2) is a semi-volatile molecule of atmospheric importance, recently proposed as a precursor in the formation of aqueous-phase secondary organic aerosol (SOA). There are few methods to measure glycolaldehyde vapor, but infrared spectroscopy has been used successfully. Using vetted protocols we have completed the first assignment of all fundamental vibrational modes and derived quantitative IR absorption band strengths using both neat and pressure-broadened GA vapor. Even though GA is problematic due to its propensity to both dimerize and condense, our intensities agree well with the few previously published values. Using the reference ?10 band Q-branch at 860.51 cm-1, we have also determined GA mixing ratios in biomass burning plumes generated by field and laboratory burns of fuels from the southeastern and southwestern United States, including the first field measurements of glycolaldehyde in smoke. The GA emission factors were anti-correlated with modified combustion efficiency confirming release of GA from smoldering combustion. The GA emission factors (g of GA emitted per kg dry biomass burned on a dry mass basis) had a low dependence on fuel type consistent with the production mechanism being pyrolysis of cellulose. GA was emitted at 0.23 0.13% of CO from field fires and we calculate that it accounts for ~18% of the aqueous-phase SOA precursors that we were able to measure.

  18. FOAM (Functional Ontology Assignments for Metagenomes): A Hidden Markov Model (HMM) database with environmental focus

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Prestat, Emmanuel; David, Maude M.; Hultman, Jenni; Ta , Neslihan; Lamendella, Regina; Dvornik, Jill; Mackelprang, Rachel; Myrold, David D.; Jumpponen, Ari; Tringe, Susannah G.; et al

    2014-09-26

    A new functional gene database, FOAM (Functional Ontology Assignments for Metagenomes), was developed to screen environmental metagenomic sequence datasets. FOAM provides a new functional ontology dedicated to classify gene functions relevant to environmental microorganisms based on Hidden Markov Models (HMMs). Sets of aligned protein sequences (i.e. ‘profiles’) were tailored to a large group of target KEGG Orthologs (KOs) from which HMMs were trained. The alignments were checked and curated to make them specific to the targeted KO. Within this process, sequence profiles were enriched with the most abundant sequences available to maximize the yield of accurate classifier models. An associatedmore » functional ontology was built to describe the functional groups and hierarchy. FOAM allows the user to select the target search space before HMM-based comparison steps and to easily organize the results into different functional categories and subcategories. FOAM is publicly available at http://portal.nersc.gov/project/m1317/FOAM/.« less

  19. Hanford Site Workers Apply Fixative to Lock Down Facility's Contamination

    Energy Savers [EERE]

    Handbook on Overseas Assignments Handbook on Overseas Assignments This handbook covers all types of Federal employment overseas, including details, both within DOE as well as to other agencies; transfers to approved international organizations; assignments to permanent DOE positions; cost-free experts; and personal services agreements (PSAs). This handbook contains information, guidance, sample service agreements, and related documentation that are to be used to implement the departments

  20. Laboratory evaluation of dynamic traffic assignment systems: Requirements, framework, and system design

    SciTech Connect (OSTI)

    Miaou, S.-P.; Pillai, R.S.; Summers, M.S.; Rathi, A.K.; Lieu, H.C.

    1997-01-01

    The success of Advanced Traveler Information 5ystems (ATIS) and Advanced Traffic Management Systems (ATMS) depends on the availability and dissemination of timely and accurate estimates of current and emerging traffic network conditions. Real-time Dynamic Traffic Assignment (DTA) systems are being developed to provide the required timely information. The DTA systems will provide faithful and coherent real-time, pre-trip, and en-route guidance/information which includes routing, mode, and departure time suggestions for use by travelers, ATIS, and ATMS. To ensure the credibility and deployment potential of such DTA systems, an evaluation system supporting all phases of DTA system development has been designed and presented in this paper. This evaluation system is called the DTA System Laboratory (DSL). A major component of the DSL is a ground- truth simulator, the DTA Evaluation System (DES). The DES is envisioned to be a virtual representation of a transportation system in which ATMS and ATIS technologies are deployed. It simulates the driving and decision-making behavior of travelers in response to ATIS and ATMS guidance, information, and control. This paper presents the major evaluation requirements for a DTA Systems, a modular modeling framework for the DES, and a distributed DES design. The modeling framework for the DES is modular, meets the requirements, can be assembled using both legacy and independently developed modules, and can be implemented as a either a single process or a distributed system. The distributed design is extendible, provides for the optimization of distributed performance, and object-oriented design within each distributed component. A status report on the development of the DES and other research applications is also provided.

  1. Acquisition Guide Chapter 4.6- Assigning Identifying Numbers Outside of the Strategic Integrated Procurement Enterprise System (STRIPES)

    Broader source: Energy.gov [DOE]

    The subject guide chapter provides guidance on the DOE's procedures for assigning identifying numbers to all new requisitions, solicitations and business instruments processed outside of STRIPES. This Guide Chapter does not apply to instrument numbers issued and business instruments awarded prior to the deployment of STRIPES at the DOE.

  2. Arranging Prescription Drug Coverage for Extended Stays (Travel or Long-Term Work Assignments) When Outside the United States

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Arranging Prescription Drug Coverage for Extended Stays (Travel or Long-Term Work Assignments) When Outside the United States Planning an extended vacation or working abroad? rx_lanl_override_0311 Maintaining prescription coverage and accessing care for long-term stays abroad What you need to know about override requests and obtaining Rx drugs. Your BCBSNM prescription drug coverage limits override requests to a 90-day supply. Override requests cannot be approved - and are not available -

  3. Identification of a distinct type IV collagen. alpha. chain with restricted kidney distribution and assignment of its gene to the locus of X chromosome-linked Alport syndrome

    SciTech Connect (OSTI)

    Hostikka, S.L.; Hoeyhtyae, M.; Tryggvason, K. ); Eddy, R.L.; Byers, M.G.; Shows, T.B. )

    1990-02-01

    The authors have identified and extensively characterized a type IV collagen {alpha} chain, referred to as {alpha}5(IV). Four overlapping cDNA clones isolated contain an open reading frame for 543 amino acid residues of the carboxyl-terminal end of a collagenous domain, a 229-residue carboxyl-terminal noncollagenous domain, and 1201 base pairs coding for a 3{prime} untranslated region. The collagenous Gly-Xaa-Yaa repeat sequence has five imperfections that coincide with those in the corresponding region of the {alpha}1(IV) chain. The noncollagenous domain has 12 conserved cysteine residues and 83% and 63% sequence identity with the noncollagenous domains of the {alpha}1(IV) and {alpha}2(IV) chains, respectively. The {alpha}5(IV) chain has less sequence identity with the putative bovine {alpha}3(IV) and {alpha}4(IV) chains. Antiserum against an {alpha}5(IV) synthetic peptide stained a polypeptide chain of about 185 kDa by immunoblot analysis and immunolocalization of the chain in human kidney was almost completely restricted to the glomerulus. The gene was assigned to the Xq22 locus by somatic cell hybrids and in situ hybridization. This may be identical or close to the locus of the X chromosome-linked Alport syndrome that is believed to be a type IV collagen disease.

  4. Overseas Development Institute | Open Energy Information

    Open Energy Info (EERE)

    mission is to inspire and inform policy and practice which lead to the reduction of poverty, the alleviation of suffering and the achievement of sustainable livelihoods in...

  5. METHODOLOGY AND CALCULATIONS FOR THE ASSIGNMENT OF WASTE GROUPS FOR THE LARGE UNDERGROUND WASTE STORAGE TANKS AT THE HANFORD SITE

    SciTech Connect (OSTI)

    WEBER RA

    2009-01-16

    The Hanford Site contains 177 large underground radioactive waste storage tanks (28 double-shell tanks and 149 single-shell tanks). These tanks are categorized into one of three waste groups (A, B, and C) based on their waste and tank characteristics. These waste group assignments reflect a tank's propensity to retain a significant volume of flammable gases and the potential of the waste to release retained gas by a buoyant displacement gas release event. Assignments of waste groups to the 177 double-shell tanks and single-shell tanks, as reported in this document, are based on a Monte Carlo analysis of three criteria. The first criterion is the headspace flammable gas concentration following release of retained gas. This criterion determines whether the tank contains sufficient retained gas such that the well-mixed headspace flammable gas concentration would reach 100% of the lower flammability limit if the entire tank's retained gas were released. If the volume of retained gas is not sufficient to reach 100% of the lower flammability limit, then flammable conditions cannot be reached and the tank is classified as a waste group C tank independent of the method the gas is released. The second criterion is the energy ratio and considers whether there is sufficient supernatant on top of the saturated solids such that gas-bearing solids have the potential energy required to break up the material and release gas. Tanks that are not waste group C tanks and that have an energy ratio < 3.0 do not have sufficient potential energy to break up material and release gas and are assigned to waste group B. These tanks are considered to represent a potential induced flammable gas release hazard, but no spontaneous buoyant displacement flammable gas release hazard. Tanks that are not waste group C tanks and have an energy ratio {ge} 3.0, but that pass the third criterion (buoyancy ratio < 1.0, see below) are also assigned to waste group B. Even though the designation as a waste

  6. METHODOLOGY AND CALCULATIONS FOR THE ASSIGNMENT OF WASTE GROUPS FOR THE LARGE UNDERGROUND WASTE STORAGE TANKS AT THE HANFORD SITE

    SciTech Connect (OSTI)

    FOWLER KD

    2007-12-27

    This document categorizes each of the large waste storage tanks into one of several categories based on each tank's waste characteristics. These waste group assignments reflect a tank's propensity to retain a significant volume of flammable gases and the potential of the waste to release retained gas by a buoyant displacement event. Revision 7 is the annual update of the calculations of the flammable gas Waste Groups for DSTs and SSTs. The Hanford Site contains 177 large underground radioactive waste storage tanks (28 double-shell tanks and 149 single-shell tanks). These tanks are categorized into one of three waste groups (A, B, and C) based on their waste and tank characteristics. These waste group assignments reflect a tank's propensity to retain a significant volume of flammable gases and the potential of the waste to release retained gas by a buoyant displacement gas release event. Assignments of waste groups to the 177 double-shell tanks and single-shell tanks, as reported in this document, are based on a Monte Carlo analysis of three criteria. The first criterion is the headspace flammable gas concentration following release of retained gas. This criterion determines whether the tank contains sufficient retained gas such that the well-mixed headspace flammable gas concentration would reach 100% of the lower flammability limit if the entire tank's retained gas were released. If the volume of retained gas is not sufficient to reach 100% of the lower flammability limit, then flammable conditions cannot be reached and the tank is classified as a waste group C tank independent of the method the gas is released. The second criterion is the energy ratio and considers whether there is sufficient supernatant on top of the saturated solids such that gas-bearing solids have the potential energy required to break up the material and release gas. Tanks that are not waste group C tanks and that have an energy ratio < 3.0 do not have sufficient potential energy to break up

  7. Advancing Usability Evaluation through Human Reliability Analysis

    SciTech Connect (OSTI)

    Ronald L. Boring; David I. Gertman

    2005-07-01

    This paper introduces a novel augmentation to the current heuristic usability evaluation methodology. The SPAR-H human reliability analysis method was developed for categorizing human performance in nuclear power plants. Despite the specialized use of SPAR-H for safety critical scenarios, the method also holds promise for use in commercial off-the-shelf software usability evaluations. The SPAR-H method shares task analysis underpinnings with human-computer interaction, and it can be easily adapted to incorporate usability heuristics as performance shaping factors. By assigning probabilistic modifiers to heuristics, it is possible to arrive at the usability error probability (UEP). This UEP is not a literal probability of error but nonetheless provides a quantitative basis to heuristic evaluation. When combined with a consequence matrix for usability errors, this method affords ready prioritization of usability issues.

  8. METHODOLOGY & CALCULATIONS FOR THE ASSIGNMENT OF WASTE GROUPS FOR THE LARGE UNDERGROUND WASTE STORAGE TANKS AT THE HANFORD SITE

    SciTech Connect (OSTI)

    BARKER, S.A.

    2006-07-27

    Waste stored within tank farm double-shell tanks (DST) and single-shell tanks (SST) generates flammable gas (principally hydrogen) to varying degrees depending on the type, amount, geometry, and condition of the waste. The waste generates hydrogen through the radiolysis of water and organic compounds, thermolytic decomposition of organic compounds, and corrosion of a tank's carbon steel walls. Radiolysis and thermolytic decomposition also generates ammonia. Nonflammable gases, which act as dilutents (such as nitrous oxide), are also produced. Additional flammable gases (e.g., methane) are generated by chemical reactions between various degradation products of organic chemicals present in the tanks. Volatile and semi-volatile organic chemicals in tanks also produce organic vapors. The generated gases in tank waste are either released continuously to the tank headspace or are retained in the waste matrix. Retained gas may be released in a spontaneous or induced gas release event (GRE) that can significantly increase the flammable gas concentration in the tank headspace as described in RPP-7771. The document categorizes each of the large waste storage tanks into one of several categories based on each tank's waste characteristics. These waste group assignments reflect a tank's propensity to retain a significant volume of flammable gases and the potential of the waste to release retained gas by a buoyant displacement event. Revision 5 is the annual update of the methodology and calculations of the flammable gas Waste Groups for DSTs and SSTs.

  9. METHODOLOGY & CALCULATIONS FOR THE ASSIGNMENT OF WASTE FOR THE LARGE UNDERGROUND WASTE STORAGE TANKS AT THE HANFORD SITE

    SciTech Connect (OSTI)

    TU, T.A.

    2007-01-04

    Waste stored within tank farm double-shell tanks (DST) and single-shell tanks (SST) generates flammable gas (principally hydrogen) to varying degrees depending on the type, amount, geometry, and condition of the waste. The waste generates hydrogen through the radiolysis of water and organic compounds, thermolytic decomposition of organic compounds, and corrosion of a tank's carbon steel walls. Radiolysis and thermolytic decomposition also generates ammonia. Nonflammable gases, which act as dilutents (such as nitrous oxide), are also produced. Additional flammable gases (e.g., methane) are generated by chemical reactions between various degradation products of organic chemicals present in the tanks. Volatile and semi-volatile organic chemicals in tanks also produce organic vapors. The generated gases in tank waste are either released continuously to the tank headspace or are retained in the waste matrix. Retained gas may be released in a spontaneous or induced gas release event (GRE) that can significantly increase the flammable gas concentration in the tank headspace as described in RPP-7771, Flammable Gas Safety Isme Resolution. Appendices A through I provide supporting information. The document categorizes each of the large waste storage tanks into one of several categories based on each tank's waste and characteristics. These waste group assignments reflect a tank's propensity to retain a significant volume of flammable gases and the potential of the waste to release retained gas by a buoyant displacement event. Revision 6 is the annual update of the flammable gas Waste Groups for DSTs and SSTs.

  10. ORISE: Protecting Human Subjects

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protecting Human Subjects Protecting Human Subjects The U.S. Department of Energy (DOE) Human Subjects Research Program exists to ensure that all research conducted at DOE ...

  11. Human Resources Specialist (Human Resources Development)

    Broader source: Energy.gov [DOE]

    This position is located in the Leadership and Organizational Development group of Learning and Development (NHT), Human Capital Management (NH), Chief Administrative Officer (N). Human Capital...

  12. GALAXIES IN X-RAY GROUPS. I. ROBUST MEMBERSHIP ASSIGNMENT AND THE IMPACT OF GROUP ENVIRONMENTS ON QUENCHING

    SciTech Connect (OSTI)

    George, Matthew R.; Bundy, Kevin; Leauthaud, Alexie; Finoguenov, Alexis; Tinker, Jeremy; Lin, Yen-Ting; Mei, Simona; Kneib, Jean-Paul; Ilbert, Olivier; Aussel, Herve; Le Floc'h, Emeric; Behroozi, Peter S.; Busha, Michael T.; Capak, Peter; Coccato, Lodovico; Covone, Giovanni; Faure, Cecile; Fiorenza, Stephanie L.; and others

    2011-12-01

    Understanding the mechanisms that lead dense environments to host galaxies with redder colors, more spheroidal morphologies, and lower star formation rates than field populations remains an important problem. As most candidate processes ultimately depend on host halo mass, accurate characterizations of the local environment, ideally tied to halo mass estimates and spanning a range in halo mass and redshift, are needed. In this work, we present and test a rigorous, probabilistic method for assigning galaxies to groups based on precise photometric redshifts and X-ray-selected groups drawn from the COSMOS field. The groups have masses in the range 10{sup 13} {approx}< M{sub 200c}/M{sub Sun} {approx}< 10{sup 14} and span redshifts 0 < z < 1. We characterize our selection algorithm via tests on spectroscopic subsamples, including new data obtained at the Very Large Telescope, and by applying our method to detailed mock catalogs. We find that our group member galaxy sample has a purity of 84% and completeness of 92% within 0.5 R{sub 200c}. We measure the impact of uncertainties in redshifts and group centering on the quality of the member selection with simulations based on current data as well as future imaging and spectroscopic surveys. As a first application of our new group member catalog which will be made publicly available, we show that member galaxies exhibit a higher quenched fraction compared to the field at fixed stellar mass out to z {approx} 1, indicating a significant relationship between star formation and environment at group scales. We also address the suggestion that dusty star-forming galaxies in such groups may impact the high-l power spectrum of the cosmic microwave background and find that such a population cannot explain the low power seen in recent Sunyaev-Zel'dovich measurements.

  13. Crystallization and preliminary crystallographic analysis of recombinant human galectin-1

    SciTech Connect (OSTI)

    Scott, Stacy A.; Scott, Ken; Blanchard, Helen

    2007-11-01

    Human galectin-1 has been cloned, expressed in E. coli, purified and crystallized in the presence of both lactose (ligand) and ?-mercaptoethanol under six different conditions. The X-ray diffraction data obtained have enabled the assignment of unit-cell parameters for two novel crystal forms of human galectin-1. Galectin-1 is considered to be a regulator protein as it is ubiquitously expressed throughout the adult body and is responsible for a broad range of cellular regulatory functions. Interest in galectin-1 from a drug-design perspective is founded on evidence of its overexpression by many cancers and its immunomodulatory properties. The development of galectin-1-specific inhibitors is a rational approach to the fight against cancer because although galectin-1 induces a plethora of effects, null mice appear normal. X-ray crystallographic structure determination will aid the structure-based design of galectin-1 inhibitors. Here, the crystallization and preliminary diffraction analysis of human galectin-1 crystals generated under six different conditions is reported. X-ray diffraction data enabled the assignment of unit-cell parameters for crystals grown under two conditions, one belongs to a tetragonal crystal system and the other was determined as monoclinic P2{sub 1}, representing two new crystal forms of human galectin-1.

  14. Eliminating livelock by assigning the same priority state to each message that is inputted into a flushable routing system during N time intervals

    DOE Patents [OSTI]

    Faber, Vance

    1994-01-01

    Livelock-free message routing is provided in a network of interconnected nodes that is flushable in time T. An input message processor generates sequences of at least N time intervals, each of duration T. An input register provides for receiving and holding each input message, where the message is assigned a priority state p during an nth one of the N time intervals. At each of the network nodes a message processor reads the assigned priority state and awards priority to messages with priority state (p-1) during an nth time interval and to messages with priority state p during an (n+1) th time interval. The messages that are awarded priority are output on an output path toward the addressed output message processor. Thus, no message remains in the network for a time longer than T.

  15. Eliminating livelock by assigning the same priority state to each message that is input into a flushable routing system during N time intervals

    DOE Patents [OSTI]

    Faber, V.

    1994-11-29

    Livelock-free message routing is provided in a network of interconnected nodes that is flushable in time T. An input message processor generates sequences of at least N time intervals, each of duration T. An input register provides for receiving and holding each input message, where the message is assigned a priority state p during an nth one of the N time intervals. At each of the network nodes a message processor reads the assigned priority state and awards priority to messages with priority state (p-1) during an nth time interval and to messages with priority state p during an (n+1) th time interval. The messages that are awarded priority are output on an output path toward the addressed output message processor. Thus, no message remains in the network for a time longer than T. 4 figures.

  16. Human-machine interactions

    DOE Patents [OSTI]

    Forsythe, J. Chris; Xavier, Patrick G.; Abbott, Robert G.; Brannon, Nathan G.; Bernard, Michael L.; Speed, Ann E.

    2009-04-28

    Digital technology utilizing a cognitive model based on human naturalistic decision-making processes, including pattern recognition and episodic memory, can reduce the dependency of human-machine interactions on the abilities of a human user and can enable a machine to more closely emulate human-like responses. Such a cognitive model can enable digital technology to use cognitive capacities fundamental to human-like communication and cooperation to interact with humans.

  17. Current trends in mapping human genes

    SciTech Connect (OSTI)

    Mckusick, V.A. )

    1991-01-01

    The human is estimated to have at least 50,000 expressed genes (gene loci). Some information is available concerning about 5,000 of these gene loci and about 1,900 have been mapped, i.e., assigned to specific chromosomes (and in most instances particular chromosome regions). Progress has been achieved by a combination of physical mapping (e.g., study of somatic cell hybrids and chromosomal in situ hybridization) and genetic mapping (e.g., genetic linkage studies). New methods for both physical and genetic mapping are expanding the armamentarium. The usefulness of the mapping information is already evident; the spin-off from the Human Genome Project (HGP) begins immediately. the complete nucleotide sequence is the ultimate map of the human genome. Sequencing, although already under way for limited segments of the genome, will await further progress in gene mapping, and in particular creation of contig maps for each chromosome. Meanwhile the technology of sequencing and sequence information handling will be developed.

  18. ORISE: Human Subjects Protection

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Subjects Protection The Oak Ridge Institute for Science and Education (ORISE) ... U.S. Department of Energy (DOE) laboratories involved in human subjects research projects. ...

  19. Jefferson Lab Human Resources

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources The Human Resources team is fully integrated with Jefferson Lab's mission, committed to providing quality customer service based on expertise, innovation and ...

  20. Human Reliability Assessment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Signup SlideShare Human Reliability Assessment HomeStationary PowerNuclear EnergyNuclear Energy Safety TechnologiesRisk and Safety AssessmentHuman Reliability Assessment ...

  1. ARM - Human Causes

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Study Hall About ARM Global Warming FAQ Just for Fun Meet our Friends Cool Sites Teachers Teachers' Toolbox Lesson Plans Human Causes Some of the human activities which can cause ...

  2. Human Genome: DOE Origins

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Genome Research: DOE Origins Resources with Additional Information Charles DeLisi Charles DeLisi The genesis of the Department of Energy (DOE) human genome project took place ...

  3. Predicting Tissue-Specific Enhancers in the Human Genome

    SciTech Connect (OSTI)

    Pennacchio, Len A.; Loots, Gabriela G.; Nobrega, Marcelo A.; Ovcharenko, Ivan

    2006-07-01

    Determining how transcriptional regulatory signals areencoded in vertebrate genomes is essential for understanding the originsof multi-cellular complexity; yet the genetic code of vertebrate generegulation remains poorly understood. In an attempt to elucidate thiscode, we synergistically combined genome-wide gene expression profiling,vertebrate genome comparisons, and transcription factor binding siteanalysis to define sequence signatures characteristic of candidatetissue-specific enhancers in the human genome. We applied this strategyto microarray-based gene expression profiles from 79 human tissues andidentified 7,187 candidate enhancers that defined their flanking geneexpression, the majority of which were located outside of knownpromoters. We cross-validated this method for its ability to de novopredict tissue-specific gene expression and confirmed its reliability in57 of the 79 available human tissues, with an average precision inenhancer recognition ranging from 32 percent to 63 percent, and asensitivity of 47 percent. We used the sequence signatures identified bythis approach to assign tissue-specific predictions to ~;328,000human-mouse conserved noncoding elements in the human genome. Byoverlapping these genome-wide predictions with a large in vivo dataset ofenhancers validated in transgenic mice, we confirmed our results with a28 percent sensitivity and 50 percent precision. These results indicatethe power of combining complementary genomic datasets as an initialcomputational foray into the global view of tissue-specific generegulation in vertebrates.

  4. Report: EM Human Capital Initiatives

    Office of Environmental Management (EM)

    HUMAN CAPITAL September 25, 2008 Submitted by the EMAB Human Capital Subcommittee Background: The enhancement of the Office of Environmental Management's (EM) human capital has ...

  5. Corporate Human Resources Information Services (CHIRS) PIA, Office of Human

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Capitol Management | Department of Energy Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol Management Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol Management Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol Management Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol Management (80.67 KB) More Documents & Publications MOX Services Unclassified

  6. Program Assignments | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Balanced Scorecard Program Officer Contractual Services Budget Officer Headquarters Purchase Card Program Headquarters Contract Closeout Headquarters Data Mining Programs Strategic ...

  7. JOBAID-ASSIGNING DELEGATES (SUPERVISOR)

    Broader source: Energy.gov [DOE]

    The purpose of this job aid is to guide you through the step-by-step process of isung the delegate feature within SuccessFactors Learning.

  8. SRR Staff Send the Holidays to Soldiers Overseas

    Broader source: Energy.gov [DOE]

    A request for razors from a U.S. Army private serving in Afghanistan transformed into a full-scale holiday gift rescue operation by employees of the Savannah River Site’s liquid waste contractor,...

  9. Ligncellulosic feedstock supply systems with intermodal and overseas...

    Office of Scientific and Technical Information (OSTI)

    With growing demand for biomass from industrial uses and international trade, the logistic operations required to economically move the biomass from the field or forest to the end ...

  10. Microsoft Word - DOE Overseas Corps Training Program _Final complete...

    Broader source: Energy.gov (indexed) [DOE]

    ... nuclear energy, electrical power, renewable energy, energy market dynamics, energy ... Scope: Albania; Austria; Belgium; BosniaHerzegovina; Bulgaria; Croatia; Cyprus; Czech ...

  11. NbF{sub 5} and TaF{sub 5}: Assignment of {sup 19}F NMR resonances and chemical bond analysis from GIPAW calculations

    SciTech Connect (OSTI)

    Biswal, Mamata; Body, Monique; Legein, Christophe; Sadoc, Aymeric; Boucher, Florent

    2013-11-15

    The {sup 19}F isotropic chemical shifts (?{sub iso}) of two isomorphic compounds, NbF{sub 5} and TaF{sub 5}, which involve six nonequivalent fluorine sites, have been experimentally determined from the reconstruction of 1D {sup 19}F MAS NMR spectra. In parallel, the corresponding {sup 19}F chemical shielding tensors have been calculated using the GIPAW method for both experimental and DFT-optimized structures. Furthermore, the [M{sub 4}F{sub 20}] units of NbF{sub 5} and TaF{sub 5} being held together by van der Waals interactions, the relevance of Grimme corrections to the DFT optimization processes has been evaluated. However, the semi-empirical dispersion correction term introduced by such a method does not show any significant improvement. Nonetheless, a complete and convincing assignment of the {sup 19}F NMR lines of NbF{sub 5} and TaF{sub 5} is obtained, ensured by the linearity between experimental {sup 19}F ?{sub iso} values and calculated {sup 19}F isotropic chemical shielding ?{sub iso} values. The effects of the geometry optimizations have been carefully analyzed, confirming among other matters, the inaccuracy of the experimental structure of NbF{sub 5}. The relationships between the fluorine chemical shifts, the nature of the fluorine atoms (bridging or terminal), the position of the terminal ones (opposite or perpendicular to the bridging ones), the fluorine charges, the ionicity and the length of the MF bonds have been established. Additionally, for three of the {sup 19}F NMR lines of NbF{sub 5}, distorted multiplets, arising from {sup 1}J-coupling and residual dipolar coupling between the {sup 19}F and {sup 93}Nb nuclei, were simulated yielding to values of {sup 93}Nb{sup 19}F {sup 1}J-coupling for the corresponding fluorine sites. - Graphical abstract: The complete assignment of the {sup 19}F NMR lines of NbF{sub 5} and TaF{sub 5} allow establishing relationships between the {sup 19}F ?{sub iso} values, the nature of the fluorine atoms (bridging or

  12. Human Genome: DOE Origins

    Office of Scientific and Technical Information (OSTI)

    of the Department of Energy; DOE Technical Report; 1988 Mapping and Sequencing the Human Genome; DOE Technical Report; 1988 Understanding our Genetic Inheritance: The U.S....

  13. Jefferson Lab Human Resources

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Sponsor click on this link to nominate a student: SPONSOR NOMINATION FORM If you have any questions please contact: Human Resources Jefferson Science Associates 628 Hofstadter Rd., ...

  14. Jefferson Lab Human Resources

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    JLab Diversity Policies 200 Human Resources 202 Equal Employment Opportunity and Affirmative Action 203 Employment 208 Employee Performance and Conduct 209 Staff Development 210 ...

  15. Jefferson Lab Human Resources

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources Consultants Cassandra Andrews, HR Consultant, Employee Relations & Recruitment (757) 269-7068, candrews@jlab.org Kelly Allmon, HR Consultant, Recruitment & ...

  16. sup 1 H and sup 31 P-NMR assignments of the non-exchangeable protons of the consensus acceptor exon:intron junction d(CpTpApCpApGpGpT)

    SciTech Connect (OSTI)

    Lown, J.W.; Chang, D.K.; Debart, F.; Rayner, B.; Imbach, J.L. )

    1986-06-01

    The consensus acceptor exon:intron junction d(CpTpApCpApGpGpT) has been synthesized by a modified phosphotriester method. The non-self complementary octamer exists in the single strand form in aqueous buffer at 20 degrees C as evidenced by temperature variable {sup 1}H-NMR and NOE measurements. The non-exchangeable proton assignments were secured using a combination of techniques including two-dimensional COSY, NOESY and the double quantum technique {sup 1}H-{sup 1}H-INADEQUATE as well as inversion recovery T1 experiments. The new technique of {sup 31}P-1H shift correlation is particularly valuable in removing certain ambiguities in the sugar proton assignments. Characteristic chemical shifts for the base protons which are determined by their immediate molecular environments are also useful in assignments. The consensus acceptor exon:intron junction adopts a random coil conformation in solution under the experimental conditions employed.

  17. Protection of Human Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-05-15

    To establish DOE procedures and responsibilities for implementing the policy and requirements set forth in 10 CFR Part 745, Protection of Human Subjects, ad in DOE P 443.1, Policy on the Protection of Human Subjects. Cancels DOE O 1300.3. Canceled by DOE O 443.1A.

  18. Protection of Human Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2007-12-20

    The order establishes Department of Energy (DOE) procedures and responsibilities for implementing the policy and requirements set forth in 10 Code of Federal Regulations (CFR) Part 745, Protection of Human Subjects; and in DOE P 443.1A, Protection of Human Subjects, dated 12-20-07. Cancels DOE O 443.1. Canceled by DOE O 443.1B.

  19. The human genome project

    SciTech Connect (OSTI)

    Yager, T.D.; Zewert, T.E.; Hood, L.E. )

    1994-04-01

    The Human Genome Project (HGP) is a coordinated worldwide effort to precisely map the human genome and the genomes of selected model organisms. The first explicit proposal for this project dates from 1985 although its foundations (both conceptual and technological) can be traced back many years in genetics, molecular biology, and biotechnology. The HGP has matured rapidly and is producing results of great significance.

  20. Human Genome Project

    SciTech Connect (OSTI)

    Block, S.; Cornwall, J.; Dally, W.; Dyson, F.; Fortson, N.; Joyce, G.; Kimble, H. J.; Lewis, N.; Max, C.; Prince, T.; Schwitters, R.; Weinberger, P.; Woodin, W. H.

    1998-01-04

    The study reviews Department of Energy supported aspects of the United States Human Genome Project, the joint National Institutes of Health/Department of Energy program to characterize all human genetic material, to discover the set of human genes, and to render them accessible for further biological study. The study concentrates on issues of technology, quality assurance/control, and informatics relevant to current effort on the genome project and needs beyond it. Recommendations are presented on areas of the genome program that are of particular interest to and supported by the Department of Energy.

  1. Human Reliability Program Overview

    SciTech Connect (OSTI)

    Bodin, Michael

    2012-09-25

    This presentation covers the high points of the Human Reliability Program, including certification/decertification, critical positions, due process, organizational structure, program components, personnel security, an overview of the US DOE reliability program, retirees and academia, and security program integration.

  2. Protection of Human Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2007-12-20

    The Policy is to establish DOE-specific principles for the protection of human subjects involved in DOE research. Cancels DOE P 443.1. Canceled by DOE O 443.1B

  3. Protection of Human Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-05-15

    The purpose of this Policy is to establish DOE-specific policy for the protection of human subjects involved in DOE research. Canceled by DOE P 443.1A.

  4. Human Resource Management Delegation

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-06-28

    The notice is to clarifies and updates existing Human Resource Management Delegation Authorities and the levels to which they are delegated. Expired 6-28-97. Does not cancel any directives.

  5. ORISE: Protecting Human Subjects Website

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protecting Human Subjects Website Institutions that engage in human subjects research are required by federal policy to establish an institutional review board (IRB) to ensure that ...

  6. Human Resources | The Ames Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources The mission of the Human Resource Department is to support the goals of The Ames Laboratory by providing support services which promote a work environmnent ...

  7. Human Genome Research: Decoding DNA

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Genome Research: Decoding DNA Resources with Additional Information Charles DeLisi ... role in proposing and initiating the Human Genome Program in 1986. The U.S. ...

  8. ORISE: Human Subjects Research Database

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Subjects Research Database Section 10, Part 745 of the Code of Federal Regulations ... on all research projects that involve human subjects and that are funded by DOE, ...

  9. New light on human evolution

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    light on human evolution New light on human evolution Scientists recently unearthed 8 million-year-old gorilla fossils from the Chorora Formation in Ethiopia, which indicate the ...

  10. Human Capital - DOE Directives, Delegations, and Requirements

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Capital by Website Administrator Back

  11. Human MSH2 protein

    DOE Patents [OSTI]

    Chapelle, A. de la; Vogelstein, B.; Kinzler, K.W.

    1997-01-07

    The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +} (RER{sup +}) tumor cells. 19 figs.

  12. Human MSH2 protein

    DOE Patents [OSTI]

    de la Chapelle, Albert; Vogelstein, Bert; Kinzler, Kenneth W.

    1997-01-01

    The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.

  13. Human Resources | The Ames Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Budget Human Resources The Human Resources function in NNSA is a vital partnership between all levels of NNSA management. It requires effective collaboration with the Service Center's Office of Human Capital Management Services. The Headquarters' Office of Human Capital Management Programs is organized into the following five divisions. Policy and Planning The Policy and Planning Division will be responsible for the development, implementation, and oversight of, human resources management

  14. Human Reliability Program Handbook

    Broader source: Energy.gov [DOE]

    The Human Reliability Program is a security and safety reliability program designed to ensure that individuals who occupy positions affording access to certain materials, nuclear explosive devices, facilities, and programs meet the highest standards of reliability and physical and mental suitability.

  15. Human dimensions in cyber operations research and development priorities.

    SciTech Connect (OSTI)

    Forsythe, James Chris; Silva, Austin Ray; Stevens-Adams, Susan Marie; Bradshaw, Jeffrey

    2012-11-01

    Within cyber security, the human element represents one of the greatest untapped opportunities for increasing the effectiveness of network defenses. However, there has been little research to understand the human dimension in cyber operations. To better understand the needs and priorities for research and development to address these issues, a workshop was conducted August 28-29, 2012 in Washington DC. A synthesis was developed that captured the key issues and associated research questions. Research and development needs were identified that fell into three parallel paths: (1) human factors analysis and scientific studies to establish foundational knowledge concerning factors underlying the performance of cyber defenders; (2) development of models that capture key processes that mediate interactions between defenders, users, adversaries and the public; and (3) development of a multi-purpose test environment for conducting controlled experiments that enables systems and human performance measurement. These research and development investments would transform cyber operations from an art to a science, enabling systems solutions to be engineered to address a range of situations. Organizations would be able to move beyond the current state where key decisions (e.g. personnel assignment) are made on a largely ad hoc basis to a state in which there exist institutionalized processes for assuring the right people are doing the right jobs in the right way. These developments lay the groundwork for emergence of a professional class of cyber defenders with defined roles and career progressions, with higher levels of personnel commitment and retention. Finally, the operational impact would be evident in improved performance, accompanied by a shift to a more proactive response in which defenders have the capacity to exert greater control over the cyber battlespace.

  16. Hyaluronan in human malignancies

    SciTech Connect (OSTI)

    Sironen, R.K.; Department of Pathology, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio ; Tammi, M.; Tammi, R.; Auvinen, P.K.; Anttila, M.; Department of Gynecology and Obstetrics, Kuopio University Hospital, P.O. Box 1777, FI-70211 Kuopio ; Kosma, V-M.

    2011-02-15

    Hyaluronan, a major macropolysaccharide in the extracellular matrix of connective tissues, is intimately involved in the biology of cancer. Hyaluronan accumulates into the stroma of various human tumors and modulates intracellular signaling pathways, cell proliferation, motility and invasive properties of malignant cells. Experimental and clinicopathological evidence highlights the importance of hyaluronan in tumor growth and metastasis. A high stromal hyaluronan content is associated with poorly differentiated tumors and aggressive clinical behavior in human adenocarcinomas. Instead, the squamous cell carcinomas and malignant melanomas tend to have a reduced hyaluronan content. In addition to the stroma-cancer cell interaction, hyaluronan can influence stromal cell recruitment, tumor angiogenesis and epithelial-mesenchymal transition. Hyaluronan receptors, hyaluronan synthases and hyaluronan degrading enzymes, hyaluronidases, are involved in the modulation of cancer progression, depending on the tumor type. Furthermore, intracellular signaling and angiogenesis are affected by the degradation products of hyaluronan. Hyaluronan has also therapeutic implications since it is involved in multidrug resistance.

  17. Next Generation Safeguards Initiative Efforts at Los Alamos National Laboratory: Developing Our Human Capital FY2015

    SciTech Connect (OSTI)

    Stevens, Rebecca S.; Hawkins Erpenbeck, Heather

    2015-10-13

    This report documents the accomplishments of the Safeguards HCD Fiscal Year 2015 (FY15) Project Work Plan, highlighting LANL’s work as well as the accomplishments of our NGSI-sponsored students, graduate and postdoctoral fellows, and mid-career professionals during this past year. While fiscal year 2015 has been a year of transition in the Human Capital Development area for LANL, we are working to revitalize our efforts to promote and develop Human Capital in Safeguards and Non-proliferation and are looking forward to implementing new initiatives in the coming fiscal year and continuing to transition the knowledge of staff who have been on assignment at IAEA and Headquarters to improve our support to HCD.

  18. Human Factors Engineering Analysis Tool

    Energy Science and Technology Software Center (OSTI)

    2002-03-04

    HFE-AT is a human factors engineering (HFE) software analysis tool (AT) for human-system interface design of process control systems, and is based primarily on NUREG-0700 guidance.

  19. Global Warming and Human Health

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    American Geophysical Union Global Warming and Human Health WHEN: Jul 27, 2015 5:30 PM - ... Event Description The main reason we are concerned about human-induced climate change is ...

  20. ORISE: Protecting Human Subjects Website

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protecting Human Subjects Website Institutions that engage in human subjects research are required by federal policy to establish an institutional review board (IRB) to ensure that risks to human subjects in research are minimal and to provide protection with respect to the rights and welfare of research subjects. The Oak Ridge Institute for Science and Education (ORISE) administers the Oak Ridge Sitewide Institutional Review Board (ORSIRB) and manages the ORISE Human Subjects website. The

  1. Protection of Human Research Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-03-17

    The Order establishes DOE-specific policy and principles for the protection of human subjects involved in DOE research, and DOE procedures and responsibilities for implementing the policy and requirements set forth in Title 45 Code of Federal Regulations (CFR) Part 46, Protection of Human Subjects, and 10 CFR Part 745, Protection of Human Subjects. Supersedes DOE O 443.1B.

  2. Human Capital Management Accountability Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-08-01

    The Order establishes requirements, roles and responsibilities for the Human Capital Management Accountability Program (HCMAP) for human resources programs and personnel and ensures that human capital activities are regulatory and procedurally compliant with Federal statutes and Departmental policies. Does not cancel other directives.

  3. Human portable preconcentrator system

    DOE Patents [OSTI]

    Linker, Kevin L.; Bouchier, Francis A.; Hannum, David W.; Rhykerd, Jr., Charles L.

    2003-01-01

    A preconcentrator system and apparatus suited to human portable use wherein sample potentially containing a target chemical substance is drawn into a chamber and through a pervious screen. The screen is adapted to capture target chemicals and then, upon heating, to release those chemicals into the chamber. Chemicals captured and then released in this fashion are then carried to a portable chemical detection device such as a portable ion mobility spectrometer. In the preferred embodiment, the means for drawing sample into the chamber comprises a reversible fan which, when operated in reverse direction, creates a backpressure that facilitates evolution of captured target chemicals into the chamber when the screen is heated.

  4. HUMAN MACHINE COOPERATIVE TELEROBOTICS

    SciTech Connect (OSTI)

    William R. Hamel; Spivey Douglass; Sewoong Kim; Pamela Murray; Yang Shou; Sriram Sridharan; Ge Zhang; Scott Thayer; Rajiv V. Dubey

    2003-06-30

    The remediation and deactivation and decommissioning (D&D) of nuclear waste storage tanks using telerobotics is one of the most challenging tasks faced in environmental cleanup. Since a number of tanks have reached the end of their design life and some of them have leaks, the unstructured, uncertain and radioactive environment makes the work inefficient and expensive. However, the execution time of teleoperation consumes ten to hundred times that of direct contact with an associated loss in quality. Thus, a considerable effort has been expended to improve the quality and efficiency of telerobotics by incorporating into teleoperation and robotic control functions such as planning, trajectory generation, vision, and 3-D modeling. One example is the Robot Task Space Analyzer (RTSA), which has been developed at the Robotics and Electromechanical Systems Laboratory (REMSL) at the University of Tennessee in support of the D&D robotic work at the Oak Ridge National Laboratory and the National Energy Technology Laboratory. This system builds 3-D models of the area of interest in task space through automatic image processing and/or human interactive manual modeling. The RTSA generates a task plan file, which describes the execution of a task including manipulator and tooling motions. The high level controller of the manipulator interprets the task plan file and executes the task automatically. Thus, if the environment is not highly unstructured, a tooling task, which interacts with environment, will be executed in the autonomous mode. Therefore, the RTSA not only increases the system efficiency, but also improves the system reliability because the operator will act as backstop for safe operation after the 3-D models and task plan files are generated. However, unstructured conditions of environment and tasks necessitate that the telerobot operates in the teleoperation mode for successful execution of task. The inefficiency in the teleoperation mode led to the research

  5. Human Genome Program

    SciTech Connect (OSTI)

    Not Available

    1993-01-01

    The DOE Human Genome program has grown tremendously, as shown by the marked increase in the number of genome-funded projects since the last workshop held in 1991. The abstracts in this book describe the genome research of DOE-funded grantees and contractors and invited guests, and all projects are represented at the workshop by posters. The 3-day meeting includes plenary sessions on ethical, legal, and social issues pertaining to the availability of genetic data; sequencing techniques, informatics support; and chromosome and cDNA mapping and sequencing.

  6. PIA - Human Resources Information System (HRIS) | Department...

    Broader source: Energy.gov (indexed) [DOE]

    Information System (HRIS) PIA - Human Resources Information System (HRIS) (232.73 KB) More Documents & Publications PIA - INL PeopleSoft - Human Resource System PIA - Human ...

  7. Project ATHENA creates surrogate human organ systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Project ATHENA creates surrogate human organ systems Project ATHENA creates surrogate human organ systems The development of miniature surrogate human organs, coupled with highly ...

  8. Contractor Human Resources | National Nuclear Security Administration...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Contractor Human Resources The Contractor Human Resources mission is to provide expert advice and assistance to our customers in order to ensure quality Contractor Human Resource ...

  9. New human resources division leader selected

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    New Human Resources division leader selected New human resources division leader selected Donna J. Hampton has been named the new Human Resources Division leader. March 15, 2011 ...

  10. ORISE: Human Subjects Protection Resource Protection Book

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Subjects Protection Resource Book The Human Subjects Protection Resource Book synthesizes information currently available on the protection of human subjects in research, the ...

  11. Human subjects research handbook: Protecting human research subjects. Second edition

    SciTech Connect (OSTI)

    1996-01-30

    This handbook serves as a guide to understanding and implementing the Federal regulations and US DOE Orders established to protect human research subjects. Material in this handbook is directed towards new and continuing institutional review board (IRB) members, researchers, institutional administrators, DOE officials, and others who may be involved or interested in human subjects research. It offers comprehensive overview of the various requirements, procedures, and issues relating to human subject research today.

  12. Human portable preconcentrator system

    SciTech Connect (OSTI)

    Linker, Kevin L.; Brusseau, Charles A.; Hannum, David W.; Puissant, James G.; Varley, Nathan R.

    2003-08-12

    A preconcentrator system and apparatus suited to human portable use wherein sample potentially containing a target chemical substance is drawn into a chamber and through a pervious screen. The screen is adapted to capture target chemicals and then, upon heating, to release those chemicals into the chamber. Chemicals captured and then released in this fashion are then carried to a portable chemical detection device such as a portable ion mobility spectrometer. In the preferred embodiment, the means for drawing sample into the chamber comprises a reversible fan which, when operated in reverse direction, creates a backpressure that facilitates evolution of captured target chemicals into the chamber when the screen is heated. The screen can be positioned directly in front of the detector prior to heating to improve detection capability.

  13. Human-computer interface

    DOE Patents [OSTI]

    Anderson, Thomas G.

    2004-12-21

    The present invention provides a method of human-computer interfacing. Force feedback allows intuitive navigation and control near a boundary between regions in a computer-represented space. For example, the method allows a user to interact with a virtual craft, then push through the windshield of the craft to interact with the virtual world surrounding the craft. As another example, the method allows a user to feel transitions between different control domains of a computer representation of a space. The method can provide for force feedback that increases as a user's locus of interaction moves near a boundary, then perceptibly changes (e.g., abruptly drops or changes direction) when the boundary is traversed.

  14. Human Reliability Program Workshop

    SciTech Connect (OSTI)

    Landers, John; Rogers, Erin; Gerke, Gretchen

    2014-05-18

    A Human Reliability Program (HRP) is designed to protect national security as well as worker and public safety by continuously evaluating the reliability of those who have access to sensitive materials, facilities, and programs. Some elements of a site HRP include systematic (1) supervisory reviews, (2) medical and psychological assessments, (3) management evaluations, (4) personnel security reviews, and (4) training of HRP staff and critical positions. Over the years of implementing an HRP, the Department of Energy (DOE) has faced various challenges and overcome obstacles. During this 4-day activity, participants will examine programs that mitigate threats to nuclear security and the insider threat to include HRP, Nuclear Security Culture (NSC) Enhancement, and Employee Assistance Programs. The focus will be to develop an understanding of the need for a systematic HRP and to discuss challenges and best practices associated with mitigating the insider threat.

  15. Human Performance Modeling for Dynamic Human Reliability Analysis

    SciTech Connect (OSTI)

    Boring, Ronald Laurids; Joe, Jeffrey Clark; Mandelli, Diego

    2015-08-01

    Part of the U.S. Department of Energy’s (DOE’s) Light Water Reac- tor Sustainability (LWRS) Program, the Risk-Informed Safety Margin Charac- terization (RISMC) Pathway develops approaches to estimating and managing safety margins. RISMC simulations pair deterministic plant physics models with probabilistic risk models. As human interactions are an essential element of plant risk, it is necessary to integrate human actions into the RISMC risk framework. In this paper, we review simulation based and non simulation based human reliability analysis (HRA) methods. This paper summarizes the founda- tional information needed to develop a feasible approach to modeling human in- teractions in RISMC simulations.

  16. PIA - Human Resources - Personal Information Change Request ...

    Energy Savers [EERE]

    Human Resources - Personal Information Change Request - Idaho National Engineering Laboratory PIA - Human Resources - Personal Information Change Request - Idaho National...

  17. Careers/ Human Resources | Princeton Plasma Physics Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources Employment Opportunities Directory Environment, Safety & Health Furth Plasma Physics Library Lab Leadership Organization Chart Technology Transfer Careers Human ...

  18. Millimeter-wave optical double resonance schemes for rapid assignment of perturbed spectra, with applications to the C{sup ~} {sup 1}B{sub 2} state of SO{sub 2}

    SciTech Connect (OSTI)

    Park, G. Barratt E-mail: barratt.park@gmail.com; Womack, Caroline C.; Jiang, Jun; Field, Robert W.; Whitehill, Andrew R.; Ono, Shuhei

    2015-04-14

    Millimeter-wave detected, millimeter-wave optical double resonance (mmODR) spectroscopy is a powerful tool for the analysis of dense, complicated regions in the optical spectra of small molecules. The availability of cavity-free microwave and millimeter wave spectrometers with frequency-agile generation and detection of radiation (required for chirped-pulse Fourier-transform spectroscopy) opens up new schemes for double resonance experiments. We demonstrate a multiplexed population labeling scheme for rapid acquisition of double resonance spectra, probing multiple rotational transitions simultaneously. We also demonstrate a millimeter-wave implementation of the coherence-converted population transfer scheme for background-free mmODR, which provides a ∼10-fold sensitivity improvement over the population labeling scheme. We analyze perturbations in the C{sup ~} state of SO{sub 2}, and we rotationally assign a b{sub 2} vibrational level at 45 328 cm{sup −1} that borrows intensity via a c-axis Coriolis interaction. We also demonstrate the effectiveness of our multiplexed mmODR scheme for rapid acquisition and assignment of three predissociated vibrational levels of the C{sup ~} state of SO{sub 2} between 46 800 and 47 650 cm{sup −1}.

  19. Survey of the high resolution infrared spectrum of methane ({sup 12}CH{sub 4} and {sup 13}CH{sub 4}): Partial vibrational assignment extended towards 12000 cm{sup ?1}

    SciTech Connect (OSTI)

    Ulenikov, O. N.; Bekhtereva, E. S.; Albert, S.; Bauerecker, S.; Niederer, H. M.; Quack, M.

    2014-12-21

    We have recorded the complete infrared spectrum of methane {sup 12}CH{sub 4} and its second most abundant isotopomer {sup 13}CH{sub 4} extending from the fundamental range starting at 1000 cm{sup ?1} up to the overtone region near 12000 cm{sup ?1} in the near infrared at the limit towards the visible range, at temperatures of about 80 K and also at 298 K with Doppler limited resolution in the gas phase by means of interferometric Fourier transform spectroscopy using the Bruker IFS 125 HR prototype (ZP 2001) of the ETH Zrich laboratory. This provides the so far most complete data set on methane spectra in this range at high resolution. In the present work we report in particular those results, where the partial rovibrational analysis allows for the direct assignment of pure (J = 0) vibrational levels including high excitation. These results substantially extend the accurate knowledge of vibrational band centers to higher energies and provide a benchmark for both the comparison with theoretical results on the one hand and atmospheric spectroscopy on the other hand. We also present a simple effective Hamiltonian analysis, which is discussed in terms of vibrational level assignments and {sup 13}C isotope effects.

  20. ORISE: Human Subjects Research Database

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Subjects Research Database Section 10, Part 745 of the Code of Federal Regulations and U.S. Department of Energy (DOE) Orders 443.1 and 481.1 require the maintenance of information on all research projects that involve human subjects and that are funded by DOE, conducted in DOE facilities, performed by DOE personnel or involve DOE or contract personnel. The Oak Ridge Institute for Science and Education (ORISE) maintains the Human Subjects Research Database (HSRD) for the Office of

  1. Quantum physics and human values

    SciTech Connect (OSTI)

    Stapp, H.P.

    1989-09-01

    This report discusses the following concepts: the quantum conception of nature; the quantum conception of man; and the impact upon human values. (LSP).

  2. Human Genome Research: Decoding DNA

    Office of Scientific and Technical Information (OSTI)

    ... Speeding Up the Process of Gene Discovery Engineered Enzyme Accelerates DNA Sequencing Putting a Virus to Practical Use DOE Joint Genome Institute The Human Genome Project: ...

  3. Protection of Human Research Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2015-07-20

    Changes are made to harmonize the definitions in this Order with those in the Federal regulations for the protection of human subjects (10 CFR Part 745), specifically, splitting the definition "human subject research" into "research" and "human subject," and adopting, verbatim, the definitions of "research" and "human subject" from 10 CFR Part 745 and adding the definition of "generalizable," since the determination of whether a project is "research" in 10 CFR Part 745 hinges on whether the work being conducted is generalizable. Small corrections and updates have been made to the references, links, and organization titles.

  4. Simulating human behavior for national security human interactions.

    SciTech Connect (OSTI)

    Bernard, Michael Lewis; Hart, Dereck H.; Verzi, Stephen J.; Glickman, Matthew R.; Wolfenbarger, Paul R.; Xavier, Patrick Gordon

    2007-01-01

    This 3-year research and development effort focused on what we believe is a significant technical gap in existing modeling and simulation capabilities: the representation of plausible human cognition and behaviors within a dynamic, simulated environment. Specifically, the intent of the ''Simulating Human Behavior for National Security Human Interactions'' project was to demonstrate initial simulated human modeling capability that realistically represents intra- and inter-group interaction behaviors between simulated humans and human-controlled avatars as they respond to their environment. Significant process was made towards simulating human behaviors through the development of a framework that produces realistic characteristics and movement. The simulated humans were created from models designed to be psychologically plausible by being based on robust psychological research and theory. Progress was also made towards enhancing Sandia National Laboratories existing cognitive models to support culturally plausible behaviors that are important in representing group interactions. These models were implemented in the modular, interoperable, and commercially supported Umbra{reg_sign} simulation framework.

  5. The Human Genome Diversity Project

    SciTech Connect (OSTI)

    Cavalli-Sforza, L.

    1994-12-31

    The Human Genome Diversity Project (HGD Project) is an international anthropology project that seeks to study the genetic richness of the entire human species. This kind of genetic information can add a unique thread to the tapestry knowledge of humanity. Culture, environment, history, and other factors are often more important, but humanity`s genetic heritage, when analyzed with recent technology, brings another type of evidence for understanding species` past and present. The Project will deepen the understanding of this genetic richness and show both humanity`s diversity and its deep and underlying unity. The HGD Project is still largely in its planning stages, seeking the best ways to reach its goals. The continuing discussions of the Project, throughout the world, should improve the plans for the Project and their implementation. The Project is as global as humanity itself; its implementation will require the kinds of partnerships among different nations and cultures that make the involvement of UNESCO and other international organizations particularly appropriate. The author will briefly discuss the Project`s history, describe the Project, set out the core principles of the Project, and demonstrate how the Project will help combat the scourge of racism.

  6. The human PECAM1 gene maps to 17q23

    SciTech Connect (OSTI)

    Gumina, R.J.; Rao, P.N.; Tuinen, P. van

    1996-06-01

    We have determined the chromosomal and regional location of the gene encoding PECAM-1 (termed PECAM1 by GBI) nomenclature using a polymerase chain reaction (PCR)-based analysis of somatic cell hybrids. Analysis of a somatic cell hybrid chromosome panel established that the PECAM1 gene is on chromosome 17. Interestingly, several adhesion molecules expressed on platelets and endothelium also localize to chromosome 17: the GP1BA locus (glycoprotein (GP) Ib{alpha}) has been provisionally mapped to the region 17p12-pter, the ITGA2b (GPIIb) and the ITGB3 (GPI-IIa) loci have been confirmed to the region 17q21.32; and the ICAM2 locus has been provisionally mapped to the region 17q23-q25. To determine if the PECAM1 locus colocalizes with any of the loci for these adhesion molecules, PCR-based analysis of a regional mapping panel for human chromosome 17 was conducted. We found that the PECAM1 locus is on the long arm of chromosome 17, i the region q23-qter. To confirm this observation and obtain a more precise localization of the PECAM1 locus, fluorescence in situ hybridization was conducted. Together our data allowed assignment of the PECAM1 locus to the region 17q23. 18 refs., 2 figs.

  7. Human Reliability Analysis for Digital Human-Machine Interfaces

    SciTech Connect (OSTI)

    Ronald L. Boring

    2014-06-01

    This paper addresses the fact that existing human reliability analysis (HRA) methods do not provide guidance on digital human-machine interfaces (HMIs). Digital HMIs are becoming ubiquitous in nuclear power operations, whether through control room modernization or new-build control rooms. Legacy analog technologies like instrumentation and control (I&C) systems are costly to support, and vendors no longer develop or support analog technology, which is considered technologically obsolete. Yet, despite the inevitability of digital HMI, no current HRA method provides guidance on how to treat human reliability considerations for digital technologies.

  8. Human Genome Education Program

    SciTech Connect (OSTI)

    Richard Myers; Lane Conn

    2000-05-01

    The funds from the DOE Human Genome Program, for the project period 2/1/96 through 1/31/98, have provided major support for the curriculum development and field testing efforts for two high school level instructional units: Unit 1, ''Exploring Genetic Conditions: Genes, Culture and Choices''; and Unit 2, ''DNA Snapshots: Peaking at Your DNA''. In the original proposal, they requested DOE support for the partial salary and benefits of a Field Test Coordinator position to: (1) complete the field testing and revision of two high school curriculum units, and (2) initiate the education of teachers using these units. During the project period of this two-year DOE grant, a part-time Field-Test Coordinator was hired (Ms. Geraldine Horsma) and significant progress has been made in both of the original proposal objectives. Field testing for Unit 1 has occurred in over 12 schools (local and non-local sites with diverse student populations). Field testing for Unit 2 has occurred in over 15 schools (local and non-local sites) and will continue in 12-15 schools during the 96-97 school year. For both curricula, field-test sites and site teachers were selected for their interest in genetics education and in hands-on science education. Many of the site teachers had no previous experience with HGEP or the unit under development. Both of these first-year biology curriculum units, which contain genetics, biotechnology, societal, ethical and cultural issues related to HGP, are being implemented in many local and non-local schools (SF Bay Area, Southern California, Nebraska, Hawaii, and Texas) and in programs for teachers. These units will reach over 10,000 students in the SF Bay Area and continues to receive support from local corporate and private philanthropic organizations. Although HGEP unit development is nearing completion for both units, data is still being gathered and analyzed on unit effectiveness and student learning. The final field testing result from this analysis will

  9. Human genome. 1993 Program report

    SciTech Connect (OSTI)

    Not Available

    1994-03-01

    The purpose of this report is to update the Human Genome 1991-92 Program Report and provide new information on the DOE genome program to researchers, program managers, other government agencies, and the interested public. This FY 1993 supplement includes abstracts of 60 new or renewed projects and listings of 112 continuing and 28 completed projects. These two reports, taken together, present the most complete published view of the DOE Human Genome Program through FY 1993. Research is progressing rapidly toward 15-year goals of mapping and sequencing the DNA of each of the 24 different human chromosomes.

  10. In vitro biotransformation of tris(2-butoxyethyl) phosphate (TBOEP) in human liver and serum

    SciTech Connect (OSTI)

    Van den Eede, Nele; Erratico, Claudio; Exarchou, Vassiliki; Maho, Walid; Neels, Hugo; Covaci, Adrian

    2015-04-15

    Tris(2-butoxyethyl) phosphate (TBOEP) is a plasticizer present in indoor dust, reaching levels of several micrograms per gram. Such levels could lead to significant daily exposure of adults and children. Currently, no toxicokinetic data are available to estimate TBOEP clearance in humans after uptake and therefore, one objective of this study was to investigate intrinsic clearance of TBOEP by human liver microsome (HLM) and serum enzymes. Another objective was to generate information to identify and prioritize several metabolites of TBOEP for investigation of human exposure by biomonitoring. 1D and 2D-NMR methodologies were successfully applied on a mixture of the metabolites to confirm the structure of 3-HO-TBOEP (bis(2-butoxyethyl) 3-hydroxyl-2-butoxyethyl phosphate) and to tentatively assign structures to 1-HO-TBOEP and 2-HO-TBOEP. HO-TBOEP isomers and bis(2-butoxyethyl) phosphate (BBOEP), bis(2-butoxyethyl) hydroxyethyl phosphate (BBOEHEP) were further monitored by liquid chromatography–tandem mass spectrometry. Rates of formation of BBOEHEP and HO-TBOEP metabolites by liver enzymes were best described by the Michaelis–Menten model. Apparent K{sub m} values for BBOEHEP, 3-HO-TBOEP, and sum of 1- and 2-HO-TBOEP isomer formation were 152, 197 and 148 μM, respectively. Apparent V{sub max} values for the formation of BBOEHEP, 3-HO-TBOEP, and the sum of 1- and 2-HO-TBOEP isomers were 2560, 643, and 254 pmol/min/mg protein, respectively. No detectable formation of BBOEP occurred with liver or serum enzymes. Our findings indicate that intrinsic clearance of TBOEP is mainly catalyzed by oxidative enzymes in the liver and that its major in vitro metabolite is BBOEHEP. These findings can be applied in human biomonitoring studies and risk assessment. - Highlights: • First steps in the elucidation of TBOEP toxicokinetics • Quantification of TBOEP metabolites in human serum and liver microsomes • No detectable formation of BBOEP occurred with liver or serum

  11. Contractor Human Resource Management Programs

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-30

    The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09.

  12. Contractor Human Resource Management Programs

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-30

    The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09

  13. Protection of Human Research Subjects

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2009-12-09

    The order establishes Department of Energy (DOE) procedures and responsibilities for implementing the policy and requirements set forth in Title 10 Code of Federal Regulations (CFR) Part 745, Protection of Human Subjects, 45 CFR Part 46, and the Secretarial Policy Memorandum on Military or Intelligence-Related Human Subject Research, December 9, 2009. Supersedes DOE O 443.1A and DOE P 443.1A.

  14. JOBAID-ASSIGNING AN ALTERNATE SUPERVISOR (SUPERVISOR)

    Broader source: Energy.gov [DOE]

    The purpose of this job aid is to guide you through the step-by-step process of managing alternate supervisors within SuccessFactors Learning.

  15. New Issue: Moody's assigns Aa1 ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    revenue bonds. Rating outlooks are stable. Global Credit Research - 09 Apr 2015 Approximately 8.1 billion of debt securities affected BONNEVILLE POWER ADMINISTRATION, OR Electric...

  16. New Issue: Moody's assigns Aa1 ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2015-C revenue bonds. Rating outlooks are stable. Global Credit Research - 23 Sep 2015 Approximately 110 million of debt securities affected BONNEVILLE POWER ADMINISTRATION, OR...

  17. Organizations' Assignment of Responsibility - DOE Directives,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Delegations, and Requirements

  18. Unclassified Foreign Visits and Assignments Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2010-10-14

    The order defines a program for unclassified foreign national access to DOE sites, information, technologies, and equipment. Supersedes DOE O 142.3.

  19. Microsoft Word - CLP_Credit_Assignment_Table

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Units TRAININGEDUCATION Attendance at academic courses at an accredited college or ... (in relevant subject area or project management association) Active Membership ...

  20. Preparing for Project Implementation Assigning Accountability...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    for Each Project Save Energy Now LEADER Web Conference Project Implementation Seminar Series Save Energy Now LEADER Web Conference Agenda Seminar Series Overview ...

  1. Solar Energy Education. Humanities: activities and teacher's...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Humanities: activities and teacher's guide. Field test edition Citation Details In-Document Search Title: Solar Energy Education. Humanities: activities and teacher's guide. Field ...

  2. Habitat for Humanity | Open Energy Information

    Open Energy Info (EERE)

    Habitat for Humanity Jump to: navigation, search Name: Habitat for Humanity Place: Americus, GA Website: www.habitat.org References: NREL Technical Report: Zero Energy Home1...

  3. Human Reliability Program Orientation for Employees (Technical...

    Office of Scientific and Technical Information (OSTI)

    Human Reliability Program Orientation for Employees Citation Details In-Document Search ... PERSONNEL; RELIABILITY; US DOE HRP employee orientation, human reliability Word ...

  4. Rocky Mountain Humane Investing | Open Energy Information

    Open Energy Info (EERE)

    Rocky Mountain Humane Investing Jump to: navigation, search Name: Rocky Mountain Humane Investing Place: Allenspark, Colorado Zip: 80510 Product: Allenspark-based investment...

  5. Climate Human Capital | Open Energy Information

    Open Energy Info (EERE)

    Human Capital Jump to: navigation, search Name: Climate Human Capital Place: London, United Kingdom Zip: W1K 6NG Sector: Carbon, Renewable Energy, Services Product: Green executive...

  6. Human Capital Management | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    human capital requires comprehensive planning and analysis in order to develop, implement, and evaluate programs that support every facet of employee work life. DOE human capital ...

  7. Human Capital Management Accountability Program (HCMAP) | Department...

    Broader source: Energy.gov (indexed) [DOE]

    Human Capital Management Accountability Program (HCMAP) is an online program which serves ... and financial HR metrics that assist human resources professionals in identifying ...

  8. PIA - Human Resources - Personal Information Change Request ...

    Broader source: Energy.gov (indexed) [DOE]

    PIA - Human Resources - Personal Information Change Request - Idaho National Engineering Laboratory (278.62 KB) More Documents & Publications PIA - INL PeopleSoft - Human ...

  9. PRIVACY IMPACT ASSESSMENT: Human Resources Personal Information

    Broader source: Energy.gov (indexed) [DOE]

    Human Resources - Personal Information Change Request PIA Template Version 3 - May, 2009 ... Name of Information Human Resources - Personal Information Change Request System or IT ...

  10. PIA - Human Resources Management Information System (HRMIS) ...

    Broader source: Energy.gov (indexed) [DOE]

    Information System (HRMIS) PIA - Human Resources Management Information System (HRMIS) (490.32 KB) More Documents & Publications PIA - INL PeopleSoft - Human Resource System PIA - ...

  11. Human Capital Organization | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Human Capital Officer provides leadership to the Department of Energy (DOE) on the impact and use of policies, proposals, programs, and partnerships related to all aspects of Human ...

  12. Tiny plastic lung mimics human pulmonary function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Tiny plastic lung mimics human pulmonary function Tiny plastic lung mimics human pulmonary function Scientists are developing a miniature, tissue-engineered artificial lung that ...

  13. Human Resources Specialist - DETAIL (Recruitment) | Department...

    Energy Savers [EERE]

    Human Resources Specialist - DETAIL (Recruitment) Human Resources Specialist - DETAIL (Recruitment) Submitted by admin on Sat, 2016-08-20 00:15 Job Summary Organization Name ...

  14. Multiscale Simulations of Human Pathologies | Argonne Leadership...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Multiscale Simulations of Human Pathologies PI Name: George Karniadakis PI Email: ... of Sickle Hemoglobin Predicting Human Blood Viscosity in Silico Tightly Coupled ...

  15. DOE Human Resources Management Division - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    About Hanford Cleanup Hanford History Hanford Site Wide Programs DOE Human Resources ... DOE Human Resources Management Division Email Email Page | Print Print Page | Text ...

  16. ATHENA surrogate human organ system approaches milestone

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Latest Issue:August 2016 all issues All Issues submit ATHENA surrogate human organ ... Editor Ute Haker Email ATHENA, the "Advanced Tissue-engineered Human Ectypal Network ...

  17. Human Resources Generalist | Princeton Plasma Physics Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources Generalist Department: Human Resources Supervisor(s): Andrea Moten Staff: AM 3 Requisition Number: 1600683 The HR Generalist is responsible for performing a wide ...

  18. Project ATHENA creates surrogate human organ systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Project ATHENA creates surrogate human organ systems Alumni Link: Opportunities, News and ... All Issues submit Project ATHENA creates surrogate human organ systems The development ...

  19. The SACADA database for human reliability and human performance

    SciTech Connect (OSTI)

    Y. James Chang; Dennis Bley; Lawrence Criscione; Barry Kirwan; Ali Mosleh; Todd Madary; Rodney Nowell; Robert Richards; Emilie M. Roth; Scott Sieben; Antonios Zoulis

    2014-05-01

    Lack of appropriate and sufficient human performance data has been identified as a key factor affecting human reliability analysis (HRA) quality especially in the estimation of human error probability (HEP). The Scenario Authoring, Characterization, and Debriefing Application (SACADA) database was developed by the U.S. Nuclear Regulatory Commission (NRC) to address this data need. An agreement between NRC and the South Texas Project Nuclear Operating Company (STPNOC) was established to support the SACADA development with aims to make the SACADA tool suitable for implementation in the nuclear power plants' operator training program to collect operator performance information. The collected data would support the STPNOC's operator training program and be shared with the NRC for improving HRA quality. This paper discusses the SACADA data taxonomy, the theoretical foundation, the prospective data to be generated from the SACADA raw data to inform human reliability and human performance, and the considerations on the use of simulator data for HRA. Each SACADA data point consists of two information segments: context and performance results. Context is a characterization of the performance challenges to task success. The performance results are the results of performing the task. The data taxonomy uses a macrocognitive functions model for the framework. At a high level, information is classified according to the macrocognitive functions of detecting the plant abnormality, understanding the abnormality, deciding the response plan, executing the response plan, and team related aspects (i.e., communication, teamwork, and supervision). The data are expected to be useful for analyzing the relations between context, error modes and error causes in human performance.

  20. ATHENA, the Desktop Human "Body"

    SciTech Connect (OSTI)

    Iyer, Rashi; Harris, Jennifer

    2014-09-29

    Creating surrogate human organs, coupled with insights from highly sensitive mass spectrometry technologies, a new project is on the brink of revolutionizing the way we screen new drugs and toxic agents. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is developing four human organ constructs - liver, heart, lung and kidney - that are based on a significantly miniaturized platform. Each organ component will be about the size of a smartphone screen, and the whole ATHENA "body" of interconnected organs would fit neatly on a desk. "By developing this 'homo minutus,' we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs," said Rashi Iyer, a senior scientist at Los Alamos National Laboratory, the lead laboratory on the five-year, $19 million multi-institutional effort. The project is supported by the Defense Threat Reduction Agency (DTRA). Some 40 percent of pharmaceuticals fail their clinical trials, Iyer noted, and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success.

  1. ATHENA, the Desktop Human "Body"

    ScienceCinema (OSTI)

    Iyer, Rashi; Harris, Jennifer

    2015-01-05

    Creating surrogate human organs, coupled with insights from highly sensitive mass spectrometry technologies, a new project is on the brink of revolutionizing the way we screen new drugs and toxic agents. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is developing four human organ constructs - liver, heart, lung and kidney - that are based on a significantly miniaturized platform. Each organ component will be about the size of a smartphone screen, and the whole ATHENA "body" of interconnected organs would fit neatly on a desk. "By developing this 'homo minutus,' we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs," said Rashi Iyer, a senior scientist at Los Alamos National Laboratory, the lead laboratory on the five-year, $19 million multi-institutional effort. The project is supported by the Defense Threat Reduction Agency (DTRA). Some 40 percent of pharmaceuticals fail their clinical trials, Iyer noted, and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success.

  2. Human Resources | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Human Resources Human Resources and Administration (HRA) HRA Home About Human Resources Administration SC Correspondence Control Center (SC CCC) Contact Information Human Resources...

  3. Corporate Human Resources Information Services (CHIRS) PIA, Office...

    Broader source: Energy.gov (indexed) [DOE]

    Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol Management Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol ...

  4. About the Human Resource Management Team | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Human Resource Management Team is responsible for human capital policy, human capital and organizational management, and human capital management initiatives. The team ensures an ...

  5. WILD PIG ATTACKS ON HUMANS

    SciTech Connect (OSTI)

    Mayer, J.

    2013-04-12

    Attacks on humans by wild pigs (Sus scrofa) have been documented since ancient times. However, studies characterizing these incidents are lacking. In an effort to better understand this phenomenon, information was collected from 412 wild pig attacks on humans. Similar to studies of large predator attacks on humans, data came from a variety of sources. The various attacks compiled occurred in seven zoogeographic realms. Most attacks occurred within the species native range, and specifically in rural areas. The occurrence was highest during the winter months and daylight hours. Most happened under non-hunting circumstances and appeared to be unprovoked. Wounded animals were the chief cause of these attacks in hunting situations. The animals involved were typically solitary, male and large in size. The fate of the wild pigs involved in these attacks varied depending upon the circumstances, however, most escaped uninjured. Most human victims were adult males traveling on foot and alone. The most frequent outcome for these victims was physical contact/mauling. The severity of resulting injuries ranged from minor to fatal. Most of the mauled victims had injuries to only one part of their bodies, with legs/feet being the most frequent body part injured. Injuries were primarily in the form of lacerations and punctures. Fatalities were typically due to blood loss. In some cases, serious infections or toxemia resulted from the injuries. Other species (i.e., pets and livestock) were also accompanying some of the humans during these attacks. The fates of these animals varied from escaping uninjured to being killed. Frequency data on both non-hunting and hunting incidents of wild pig attacks on humans at the Savannah River Site, South Carolina, showed quantitatively that such incidents are rare.

  6. A reevaluation of the assignment of the vibrational fundamentals and the rotational analysis of bands in the high-resolution infrared spectra of trans- and cis- 1,3,5-hexatriene

    SciTech Connect (OSTI)

    Craig, Norman C.; Leyden, Matthew C.; Moore, Michael C.; Patchen, Amie K.; van den Heuvel, Titus; Blake, Thomas A.; Masiello, Tony; Sams, Robert L.

    2010-07-01

    Assignments of the vibrational fundamentals of cis- and trans-1,3,5-hexatriene are reevaluated with new infrared and Raman spectra and with quantum chemical predictions of intensities and anharmonic frequencies. The rotational structure is analyzed in the high-resolution (0.0013-0.0018 cm -1) infrared spectra of three C-type bands of the trans isomer and two C-type bands of the cis isomer. The bands for the trans isomer are at 1010.96 cm-1 (v14), 900.908 cm-1 (v16), and 683.46 cm-1 (v17). Ground state (GS) rotational constants have been fitted to the combined ground state combination differences (GSCDs) for the three bands of the trans isomer. The bands for the cis isomer are at 907.70 cm-1 (v33) and 587.89 cm-1 (v35). GS rotational constants have been fitted to the combined GSCDs for the two bands of the cis isomer and compared with those obtained from microwave spectroscopy. Small inertial defects in the GSs confirm that both molecules are planar. Upper state rotational constants were fitted for all five bands.

  7. Low-Income Weatherization: The Human Dimension

    Office of Energy Efficiency and Renewable Energy (EERE)

    This presentation focuses on how the human dimension saves energy within low-income weatherization programs.

  8. Analysis of Human Genetic Linkage

    SciTech Connect (OSTI)

    Boehnke, M.

    1991-01-01

    Linkage analysis continues in its golden age. The convergence of several factors - advances in molecular biology, advances in statistical models and algorithms, and advances in computing technology - have made possible remarkable successes in the mapping of human genetic diseases and in the construction of human genetic maps. The goals of mapping all the most important simple Mendelian disorders and constructing fine-structure genetic maps for each of the human chromosomes soon will be reached, and linkage methods promise to help us understand the etiologies of many common and complex familial diseases. With the continuing rapid advance of the field, the appearance of the revised edition of Dr. Ott's book is particularly welcome. As with the first edition, the goal of the revised edition is to provide a concise, easy-to-read introduction to human linkage analysis. The revised edition includes chapters on basic genetics and cytogenetics, genes and genetic polymorphisms, aspects of statistical inference, methods of linkage analysis, the informativeness of family data, multipoint linkage analysis, penetrance, numerical and computerized methods, the variability of the recombination fraction, inconsistencies, and linkage analysis with disease loci. The results is not an encyclopedia providing everything one could ever want to know about linkage analysis but, rather, a guide to the important methods, topics, and problems of linkage analysis today. Overall, the book achieves an excellent compromise between presenting important conclusions and working out the details.

  9. Human factors in software development

    SciTech Connect (OSTI)

    Curtis, B.

    1986-01-01

    This book presents an overview of ergonomics/human factors in software development, recent research, and classic papers. Articles are drawn from the following areas of psychological research on programming: cognitive ergonomics, cognitive psychology, and psycholinguistics. Topics examined include: theoretical models of how programmers solve technical problems, the characteristics of programming languages, specification formats in behavioral research and psychological aspects of fault diagnosis.

  10. Human retroviruses and AIDS 1994

    SciTech Connect (OSTI)

    Myers, G.; Korber, B.; Wain-Hobson, S.; Jeang, Kuan-Teh; Henderson, L.E.; Pavlakis, G.N.

    1995-01-01

    This compendium, including accompanying floppy diskettes, is the result of an effort to compile and rapidly publish all relevant molecular data concerning the human immunodeficiency viruses (HIV) and related retroviruses. The scope of the compendium and database is best summarized by the five parts it comprises: (I) Nucleic Acid Alignments and Sequences; (II) Amino Acid Alignments; (III) Analysis; (IV) Related Sequences; (V) Database communications.

  11. A Literary Human Exinction Scenario

    SciTech Connect (OSTI)

    Tonn, Bruce Edward

    2009-11-01

    Mary Wollstonecraft Shelly's (MWS) novel, The Last Man, published in 1826, is an epic narrative about the destruction of the human race. This paper provides a synopsis of this book and assesses its relationships to contemporary future studies. The paper also delves into the history of apocalyptic writing and thinking, using this book an entry point to past literature.

  12. DOE F 3550.2 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    550.2 DOE F 3550.2 Form used to nominate an employee for a quality Increase in pay. Nomination For Quality Increase (6.51 KB) More Documents & Publications DOE F 3450.3 DOE Federal Aviation Professional Awards Handbook on Overseas Assignments

  13. Expanding Human Cognition and Communication

    SciTech Connect (OSTI)

    Spohrer, Jim; Pierce, Brian M.; Murray, Cherry A.; Golledge, Reginald G.; Horn, Robert E.; Turkle, Sherry; Yonas, Gerold; Glicken Turnley, Jessica; Pollack, Jordan; Burger, Rudy; Robinett, Warren; Wilson, Larry Todd; Bainbridge, W. S.; Canton, J.; Kuekes, P.; Loomis, J.; Penz, P.

    2013-01-01

    To be able to chart the most profitable future directions for societal transformation and corresponding scientific research, five multidisciplinary themes focused on major goals have been identified to fulfill the overall motivating vision of convergence described in the previous pages. The first, “Expanding Human Cognition and Communication,” is devoted to technological breakthroughs that have the potential to enhance individuals’ mental and interaction abilities. Throughout the twentieth century, a number of purely psychological techniques were offered for strengthening human character and personality, but evaluation research has generally failed to confirm the alleged benefits of these methods (Druckman and Bjork 1992; 1994). Today, there is good reason to believe that a combination of methods, drawing upon varied branches of converging science and technology, would be more effective than attempts that rely upon mental training alone.

  14. Human factors in waste management

    SciTech Connect (OSTI)

    Moray, N.

    1994-10-01

    This article examines the role of human factors in radioactive waste management. Although few problems and ergonomics are special to radioactive waste management, some problems are unique especially with long term storage. The entire sociotechnical system must be looked at in order to see where improvement can take place because operator errors, as seen in Chernobyl and Bhopal, are ultimately the result of management errors.

  15. Contractor Human Resource Management Programs

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-30

    The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09; Chg 3, 2-23-10; Chg 4, 4-29-13. This order cancels DOE O 3220.1A, DOE O 3220.4A, DOE O 3220.6A, and DOE O 3309.1A.

  16. Contractor Human Resource Management Programs

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-29

    This directive establishes DOE responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09; Chg 3, 2-23-10; Chg 4, 4-29-13. DOE O 350.1 Chg 5, dated 9-30-2014, cancels Chapters I-III of DOE O 350.1 Chg 4

  17. Integrating Human Performance and Technology

    SciTech Connect (OSTI)

    Ronald K. Farris; Heather Medema

    2012-05-01

    Human error is a significant factor in the cause and/or complication of events that occur in the commercial nuclear industry. In recent years, great gains have been made using Human Performance (HU) tools focused on targeting individual behaviors. However, the cost of improving HU is growing and resistance to add yet another HU tool certainly exists, particularly for those tools that increase the paperwork for operations. Improvements in HU that are the result of leveraging existing technology, such as hand-held mobile technologies, have the potential to reduce human error in controlling system configurations, safety tag-outs, and other verifications. Operator rounds, valve line-up verifications, containment closure verifications, safety & equipment protection, and system tagging can be supported by field-deployable wireless technologies. These devices can also support the availability of critical component data in the main control room and other locations. This research pilot project reviewing wireless hand-held technology is part of the Light Water Reactor Sustainability Program (LWRSP), a research and development (R&D) program sponsored by the U. S. Department of Energy (DOE). The project is being performed in close collaboration with industry R&D programs to provide the technical foundations for licensing, and managing the long-term, safe, and economical operation of current nuclear power plants. The LWRSP vision is to develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of the current nuclear reactor fleet.

  18. Human Resource Directors (HRD) | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Office (NE) 208-526-5711 groseae@id.doe.gov Marcus Lea Director, Office of Human Cap. Mgt. ... garcia@wapa.gov Rita Clinton Director, Human Resources Services (HQ) (202) 586-1038 ...

  19. MEMORANDUM FOR HUMAN RESOLIRCES DIRECTORS FROM:

    Broader source: Energy.gov (indexed) [DOE]

    April 27,2010 MEMORANDUM FOR HUMAN RESOLIRCES DIRECTORS FROM: s r x j ) bi Le OFFICE HE CHIEF HUMAN CAPITAL OFFICER SUBJECT: GUIDANCE MEMORANDUM 8: DOE FAIR LABOR STANDARDS ACT ...

  20. Mapping the Topology of the Human Genome

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mapping the Topology of the Human Genome Mapping the Topology of the Human Genome Print Monday, 11 July 2016 00:00 Department of Energy facilities such as the Joint Genome ...

  1. 6.20 Mapping Human Brain Function

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    0 612011 6.20 Mapping Human Brain Function Many mysteries of the human brain have been unraveled by positron emission tomography (PET), an imaging tool used worldwide to diagnose ...

  2. Human Brain vs. Computer | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Computer Processors Beat the Human Mind in the Future? Click to email this to a friend ... Can Computer Processors Beat the Human Mind in the Future? 2013.01.29 Chief Scientist Jim ...

  3. History of the DOE Human Genome Program

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of the DOE Human Genome Program The following history is taken from the U.S. Department of Energy 1991-91 Human Genome Program Report (June 1992). This is an archived item. A brief ...

  4. GDB - Human Genome Database final report

    SciTech Connect (OSTI)

    Talbot, C. Conover, Jr.

    2002-01-08

    This is the DOE final report for the GDB, Human Genome Database, project at the Johns Hopkins University.

  5. Identification of Human Repetitive DNA Elements

    Energy Science and Technology Software Center (OSTI)

    1995-11-01

    PYTHIA identifies the subfamily membership of Alu sequences, occurrences of repetitive human DNA elements, and simple DNA sequences.

  6. Human factors: a necessary tool for industry

    SciTech Connect (OSTI)

    Starcher, K.O.

    1984-03-09

    The need for human factors (ergonomics) input in the layout of a ferroelectric ceramics laboratory is presented as an example of the overall need for human factors professionals in industry. However, even in the absence of one trained in human factors, knowledge of a few principles in ergonomics will provide many possibilities for improving performance in the industrial environment.

  7. Contractor Human Resource Management Programs

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1996-09-30

    This directive establishes DOE responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09; Chg 3, 2-23-10; Chg 4, 4-29-13. DOE O 350.1 Chg 5, dated 9-30-2014, supersedes DOE O 350.1 Chg 4. The Order is revised to reflect the cancellation of Chapters 1-3 due to the incorporation of these chapters into DOE Order 350.3; reflect organizational changes; delete reference to the DOE Retrospective Rating Insurance Plan, which is no longer available; remove the CRD from Chapter VII.

  8. Simulation of human decision making

    DOE Patents [OSTI]

    Forsythe, J. Chris; Speed, Ann E.; Jordan, Sabina E.; Xavier, Patrick G.

    2008-05-06

    A method for computer emulation of human decision making defines a plurality of concepts related to a domain and a plurality of situations related to the domain, where each situation is a combination of at least two of the concepts. Each concept and situation is represented in the computer as an oscillator output, and each situation and concept oscillator output is distinguishable from all other oscillator outputs. Information is input to the computer representative of detected concepts, and the computer compares the detected concepts with the stored situations to determine if a situation has occurred.

  9. Human Resources and Administration Homepage | U.S. DOE Office...

    Office of Science (SC) Website

    Home Human Resources and Administration (HRA) HRA Home About Human Resources Administration SC Correspondence Control Center (SC CCC) Contact Information Human Resources and...

  10. DOE Strategic Human Capital Plan (FY 2011 - 2015) | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Strategic Human Capital Plan (FY 2011 - 2015) DOE Strategic Human Capital Plan (FY 2011 - 2015) The Strategic Human Capital Plan sets forth the framework for managing the ...

  11. PIA - Human Resources Management System | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    System PIA - Human Resources Management System (218.23 KB) More Documents & Publications PIA - INL PeopleSoft - Human Resource System PIA - Human Resources - Personal Information ...

  12. PIA - INL PeopleSoft - Human Resource System | Department of...

    Broader source: Energy.gov (indexed) [DOE]

    PeopleSoft - Human Resource System PIA - INL PeopleSoft - Human Resource System (333.96 KB) More Documents & Publications PIA - Human Resources - Personal Information Change ...

  13. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Irradiation Effects on Human Cortical Bone Fracture Behavior Print Wednesday, 28 July 2010 00:00 Human bone is strong ...

  14. Oldest hominid skeleton provides new evidence for human evolution

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    New evidence for human evolution Oldest hominid skeleton provides new evidence for human evolution The discovery reveals the biology of the first stage of human evolution better ...

  15. Molecular clocks control mutation rate in human cells

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    All Issues submit Molecular clocks control mutation rate in human cells Mutational processes may be responsible for a large proportion of human cancer, contribute to human ...

  16. ATHENA desktop human "body" reduces need for animal drug tests

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ATHENA desktop human "body" ATHENA desktop human "body" reduces need for animal drug tests ATHENA project team is developing four human organ constructs that are based on a ...

  17. Human Reliability Analysis for Design: Using Reliability Methods for Human Factors Issues

    SciTech Connect (OSTI)

    Ronald Laurids Boring

    2010-11-01

    This paper reviews the application of human reliability analysis methods to human factors design issues. An application framework is sketched in which aspects of modeling typically found in human reliability analysis are used in a complementary fashion to the existing human factors phases of design and testing. The paper provides best achievable practices for design, testing, and modeling. Such best achievable practices may be used to evaluate and human system interface in the context of design safety certifications.

  18. DOE 0 3 13.1 Management and Funding of the Department's Overseas Presence

    Broader source: Energy.gov [DOE]

    The Department issued the above listed Directive, which includes a Contractor Requirements Document (CRD) on November 19,2009.

  19. Status of Overseas Microgrid Programs:Microgrid Research Activities in the U.S.

    SciTech Connect (OSTI)

    Marnay, Chris; Marnay, Chris; Zhou, Nan

    2008-02-01

    Research on microgrids in the U.S. has taken a somewhat different path than parallel efforts in Japan and Europe, and this distinction is often noted in international research forums. In general, reliability and power quality in North America is poor compared to other developed countries. For example, in the U.S., the average annual expected outage duration is a few hours, whereas in Japan, it is only a few minutes. Power quality problems in the U.S. are both large scale, such as the August 2003 blackout, and local, such as damaging voltage sags. Meeting the increasingly demanding requirements of a modern digital economy would then seem to offer a more daunting challenge for the U.S. than elsewhere, and certainly, concern that the existing power delivery system will prove inadequate for future gourmet requirements has been a motivating driver of U.S. research. This objective tends to translate into a desire for microgrids to seamlessly island when grid power is interrupted or its quality is inadequate, and to (also seamlessly) reconnect when normal service has been restored. In a sense, the microgrid is perceived as acting as an uninterruptible power supply (UPS), and sometimes even as a competitor to existing UPS options. Nonetheless, this difference is often over-stated, and the other threads that motivate microgrid research also exist in the U.S., e.g. the desire to expand renewable generation and the need to increase the efficiency of fossil-fired generation by the useful local application of waste heat in combined heat and power (CHP) systems, Further, over time, the differences are blurring as concerns about climate change increasingly dominate objectives worldwide. This article describes the CERTS Microgrid, which is almost certainly the best known U.S. example, and also briefly mentions some other U.S. microgrid research.

  20. Nippon Kokan technical report No. 42, December 1984: overseas. LNG technology special issue

    SciTech Connect (OSTI)

    Not Available

    1984-01-01

    Contents INCLUDE: fracture toughness of 9% Ni steel and safety of LNG storage tank; fatigue strength and safety assessment of membrane components; comparison of LNG carriers of membrane tank system and spherical tank system; diesel-driven LNG carrier with reliquefaction plant; construction of TGZ MK I system LNG carrier model tank and its cryogenic tests; vacuum insulation test using LNG model tank; estimation of impact pressure and hydrodynamic force due to sloshing in LNG carrier; Higashi-Ohgishima LNG receiving facility for the Tokyo Electric Power Co., Inc.; design of LNG receiving facility; receiving and circulation control system of Higashi-Ohgishima LNG terminal; welding procedure of LNG pipelines; the design method of inground LNG storage tank; the design method of aboveground LNG storage tank; various applications of LNG tank roll-over simulation program ROSP.

  1. Linking Humans and Systems in Nuclear Power

    SciTech Connect (OSTI)

    Jacques Hugo

    2013-02-01

    Traditional engineering methods do not make provision for the integration of human considerations, while traditional human factors methods do not scale well to the complexity of large-scale nuclear power plant projects. Although the need for up-to-date human factors engineering processes and tools is recognised widely in industry, so far no formal guidance has been developed. This article proposes such a framework.

  2. Project ATHENA creates surrogate human organ systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Project ATHENA creates surrogate human organ systems Project ATHENA creates surrogate human organ systems The development of miniature surrogate human organs, coupled with highly sensitive mass spectrometry technologies, could one day revolutionize the way new drugs and toxic agents are studied. June 15, 2015 ATHENA prototype undergoes testing. ATHENA prototype undergoes testing. Contact Los Alamos National Laboratory Kevin Roark Communications Office (505) 665-9202 Email "By developing

  3. Apparatus and methods for a human extender

    DOE Patents [OSTI]

    Jansen, John F.

    2001-01-01

    A human extender controller for interface between a human operator and a physical object through a physical plant. The human extender controller uses an inner-feedback loop to increase the equivalent damping of the operating system to stabilize the system when it contacts with the environment and reduces the impact of the environment variation by utilizing a high feedback gain, determined by a root locus sketch. Because the stability of the human extender controller of the present invention is greatly enhanced over that of the prior art, the present invention is able to achieve a force reflection ratio 500 to 1 and capable of handling loads above the two (2) ton range.

  4. Transactions, Technology and Contractor Human Relations | Department...

    Office of Environmental Management (EM)

    of the Assistant General Counsel for Contractor Human Resources (GC-63) Litigation, Regulation and Enforcement Environment and Compliance Transactions, Technology and Contractor ...

  5. Transactions, Technology & Contractor Human Resources | Department...

    Broader source: Energy.gov (indexed) [DOE]

    Panel Technician | Credit: DOE Archives Solar Panel Technician | Credit: DOE Archives Offices of the Deputy General Counsel for Transactions, Technology, & Contractor Human...

  6. Human factors challenges for advanced process control

    SciTech Connect (OSTI)

    Stubler, W.F.; O`Hara, J..M.

    1996-08-01

    New human-system interface technologies provide opportunities for improving operator and plant performance. However, if these technologies are not properly implemented, they may introduce new challenges to performance and safety. This paper reports the results from a survey of human factors considerations that arise in the implementation of advanced human-system interface technologies in process control and other complex systems. General trends were identified for several areas based on a review of technical literature and a combination of interviews and site visits with process control organizations. Human factors considerations are discussed for two of these areas, automation and controls.

  7. Human Capital Management Accountability Program (HCMAP)

    Broader source: Energy.gov [DOE]

    Human Capital Management Accountability Program (HCMAP) is an online program which serves as the vehicle for identifying and measuring these three factors, effectiveness, efficiency, and timeliness...

  8. 2014 DOE Human Reliability Program (HRP) Workshop

    Office of Energy Efficiency and Renewable Energy (EERE)

    2014 DOE Human Reliability Program (HRP) Workshop - September 17-19, at the DOE National Training Center in Albuquerque, New Mexico.

  9. Multiscale Simulations of Human Pathologies | Argonne Leadership...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Inset shows the time evolution of thrombus formation. George Karniadakis, Brown University Multiscale Simulations of Human Pathologies PI Name: George Karniadakis PI Email: ...

  10. Multiscale Simulations of Human Pathologies | Argonne Leadership...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Karniadakis, Paris Perdikaris, and Yue Yu, Brown University; Leopold Grinberg, IBM T. J. Watson Research Center and Brown University Multiscale Simulations of Human Pathologies PI ...

  11. Immunogenic compositions comprising human immunodeficiency virus...

    Office of Scientific and Technical Information (OSTI)

    Patent: Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins Citation Details In-Document Search Title: Immunogenic compositions comprising...

  12. Atomic magnetometer for human magnetoencephalograpy.

    SciTech Connect (OSTI)

    Schwindt, Peter; Johnson, Cort N.

    2010-12-01

    We have developed a high sensitivity (<5 fTesla/{radical}Hz), fiber-optically coupled magnetometer to detect magnetic fields produced by the human brain. This is the first demonstration of a noncryogenic sensor that could replace cryogenic superconducting quantum interference device (SQUID) magnetometers in magnetoencephalography (MEG) and is an important advance in realizing cost-effective MEG. Within the sensor, a rubidium vapor is optically pumped with 795 laser light while field-induced optical rotations are measured with 780 nm laser light. Both beams share a single optical axis to maximize simplicity and compactness. In collaboration with neuroscientists at The Mind Research Network in Albuquerque, NM, the evoked responses resulting from median nerve and auditory stimulation were recorded with the atomic magnetometer and a commercial SQUID-based MEG system with signals comparing favorably. Multi-sensor operation has been demonstrated with two AMs placed on opposite sides of the head. Straightforward miniaturization would enable high-density sensor arrays for whole-head magnetoencephalography.

  13. Human performance modeling for system of systems analytics: combat performance-shaping factors.

    SciTech Connect (OSTI)

    Lawton, Craig R.; Miller, Dwight Peter

    2006-01-01

    The US military has identified Human Performance Modeling (HPM) as a significant requirement and challenge of future systems modeling and analysis initiatives. To support this goal, Sandia National Laboratories (SNL) has undertaken a program of HPM as an integral augmentation to its system-of-system (SoS) analytics capabilities. The previous effort, reported in SAND2005-6569, evaluated the effects of soldier cognitive fatigue on SoS performance. The current effort began with a very broad survey of any performance-shaping factors (PSFs) that also might affect soldiers performance in combat situations. The work included consideration of three different approaches to cognition modeling and how appropriate they would be for application to SoS analytics. This bulk of this report categorizes 47 PSFs into three groups (internal, external, and task-related) and provides brief descriptions of how each affects combat performance, according to the literature. The PSFs were then assembled into a matrix with 22 representative military tasks and assigned one of four levels of estimated negative impact on task performance, based on the literature. Blank versions of the matrix were then sent to two ex-military subject-matter experts to be filled out based on their personal experiences. Data analysis was performed to identify the consensus most influential PSFs. Results indicate that combat-related injury, cognitive fatigue, inadequate training, physical fatigue, thirst, stress, poor perceptual processing, and presence of chemical agents are among the PSFs with the most negative impact on combat performance.

  14. Enhanced human papillomavirus type 8 oncogene expression levels are crucial for skin tumorigenesis in transgenic mice

    SciTech Connect (OSTI)

    Hufbauer, M.; Lazic, D.; Akguel, B.; Brandsma, J.L.; Pfister, H.; Weissenborn, S.J.

    2010-08-01

    Human papillomavirus 8 (HPV8) is involved in skin cancer development in epidermodysplasia verruciformis patients. Transgenic mice expressing HPV8 early genes (HPV8-CER) developed papillomas, dysplasias and squamous cell carcinomas. UVA/B-irradiation and mechanical wounding of HPV8-CER mouse skin led to prompt papilloma induction in about 3 weeks. The aim of this study was to analyze the kinetics and level of transgene expression in response to skin irritations. Transgene expression was already enhanced 1 to 2 days after UVA/B-irradiation or tape-stripping and maintained during papilloma development. The enhanced transgene expression could be assigned to UVB and not to UVA. Papilloma development was thus always paralleled by an increased transgene expression irrespective of the type of skin irritation. A knock-down of E6 mRNA by tattooing HPV8-E6-specific siRNA led to a delay and a lower incidence of papilloma development. This indicates that the early increase of viral oncogene expression is crucial for induction of papillomatosis.

  15. Human retroviruses and AIDS 1997

    SciTech Connect (OSTI)

    Korber, B.; Foley, B.; Leitner, T.

    1997-12-01

    This compendium is the result of an effort to compile, organize, and rapidly publish as much relevant molecular data concerning the human immunodeficiency viruses (HIV) and related retroviruses as possible. The scope of the compendium and database is best summarized by the four parts that it comprises: (1) Nucleic Acid Alignments, (2) Amino Acid Alignments, (3) Reviews and Analyses, and (4) Related Sequences. Information within all the parts is updated throughout the year on the Web site, http://hiv-web.lanl.gov. This year we are not including floppy diskettes as the entire compendium is available both at our Web site and at our ftp site. If you need floppy diskettes please contact either Bette Korber (btk@t10.lanl.gov) or Kersti Rock (karm@t10.lanl.gov) by email or fax ((505) 665-4453). While this publication could take the form of a review or sequence monograph, it is not so conceived. Instead, the literature from which the database is derived has simply been summarized and some elementary computational analyses have been performed upon the data. Interpretation and commentary have been avoided insofar as possible so that the reader can form his or her own judgments concerning the complex information. The exception to this are reviews submitted by experts in areas deemed of particular and basic importance to research involving AIDS viral sequence information. These are included in Part III, and are contributed by scientists with particular expertise in the area of interest. In addition to the general descriptions below of the parts of the compendium, the user should read the individual introductions for each part.

  16. Task Decomposition in Human Reliability Analysis

    SciTech Connect (OSTI)

    Boring, Ronald Laurids; Joe, Jeffrey Clark

    2014-06-01

    In the probabilistic safety assessments (PSAs) used in the nuclear industry, human failure events (HFEs) are determined as a subset of hardware failures, namely those hardware failures that could be triggered by human action or inaction. This approach is top-down, starting with hardware faults and deducing human contributions to those faults. Elsewhere, more traditionally human factors driven approaches would tend to look at opportunities for human errors first in a task analysis and then identify which of those errors is risk significant. The intersection of top-down and bottom-up approaches to defining HFEs has not been carefully studied. Ideally, both approaches should arrive at the same set of HFEs. This question remains central as human reliability analysis (HRA) methods are generalized to new domains like oil and gas. The HFEs used in nuclear PSAs tend to be top-down— defined as a subset of the PSA—whereas the HFEs used in petroleum quantitative risk assessments (QRAs) are more likely to be bottom-up—derived from a task analysis conducted by human factors experts. The marriage of these approaches is necessary in order to ensure that HRA methods developed for top-down HFEs are also sufficient for bottom-up applications.

  17. Human Reliability Considerations for Small Modular Reactors

    SciTech Connect (OSTI)

    OHara J. M.; Higgins, H.; DAgostino, A.; Erasmia, L.

    2012-01-27

    Small modular reactors (SMRs) are a promising approach to meeting future energy needs. Although the electrical output of an individual SMR is relatively small compared to that of typical commercial nuclear plants, they can be grouped to produce as much energy as a utility demands. Furthermore, SMRs can be used for other purposes, such as producing hydrogen and generating process heat. The design characteristics of many SMRs differ from those of current conventional plants and may require a distinct concept of operations. The U.S. Nuclear Regulatory Commission (NRC) conducted research to examine the human factors engineering and the operational aspects of SMRs. The research identified thirty potential human-performance issues that should be considered in the NRC's reviews of SMR designs and in future research activities. The purpose of this report is to illustrate how the issues can support SMR probabilistic risk analyses and their review by identifying potential human failure events for a subset of the issues. As part of addressing the human contribution to plant risk, human reliability analysis practitioners identify and quantify the human failure events that can negatively impact normal or emergency plant operations. The results illustrated here can be generalized to identify additional human failure events for the issues discussed and can be applied to those issues not discussed in this report.

  18. Human dopamine receptor and its uses

    DOE Patents [OSTI]

    Civelli, Olivier; Van Tol, Hubert Henri-Marie

    1999-01-01

    The present invention is directed toward the isolation, characterization and pharmacological use of the human D4 dopamine receptor. The nucleotide sequence of the gene corresponding to this receptor and alleleic variant thereof are provided by the invention. The invention also includes recombinant eukaryotic expression constructs capable of expressing the human D4 dopamine receptor in cultures of transformed eukaryotic cells. The invention provides cultures of transformed eukaryotic cells which synthesize the human D4 dopamine receptor, and methods for characterizing novel psychotropic compounds using such cultures.

  19. Mapping the Topology of the Human Genome

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mapping the Topology of the Human Genome Mapping the Topology of the Human Genome Print Monday, 11 July 2016 00:00 Department of Energy facilities such as the Joint Genome Institute provide us with DNA sequences for entire genomes, most famously the human genome. However, a DNA sequence alone isn't sufficient to determine how a gene will function in a cell, or if indeed it will be functional at all. We also need to know the spatial 3D arrangement of the genome in the nucleus. A single strand of

  20. Full differentiation and assignment of boron species in the electrolytes Li{sub 2}B{sub 6}O{sub 9}F{sub 2} and Li{sub 2}B{sub 3}O{sub 4}F{sub 3} by solid-state {sup 11}B NMR spectroscopy

    SciTech Connect (OSTI)

    Braeuniger, Thomas; Pilz, Thomas; Chandran, C. Vinod; Jansen, Martin

    2012-10-15

    The syntheses of two new fluorooxoborates, Li{sub 2}B{sub 3}O{sub 4}F{sub 3} and Li{sub 2}B{sub 6}O{sub 9}F{sub 2}, which possess considerable ion conductivity at higher temperatures, have been reported recently. Here, we describe the characterisation of these compounds by solid-state {sup 11}B NMR spectroscopy. The complex central-transition MAS spectra, resulting from overlap of sub-spectra contributed by the individual boron species in the crystal structures, could be clearly separated by acquisition and analysis of 3QMAS spectra. By numerical fit of these sub-spectra, the isotropic chemical shift {delta}{sub iso}, the quadrupolar coupling constant {chi}, and the asymmetry {eta} were determined. Using known relations between boron coordination and chemical shift as well as quadrupolar coupling, the individual {sup 11}B NMR resonances have been ascribed to boron species in tetrahedral or trigonal environment. To remove remaining assignment ambiguities, the response of the {sup 11}B resonances to {sup 19}F decoupling was qualitatively analysed. Thus, by using the combined information conveyed by chemical shift, quadrupolar and dipolar interaction, a complete assignment of the complex {sup 11}B line shapes exhibited by the fluorooxoborates has been achieved. - Graphical abstract: Structure and solid-state {sup 11}B NMR spectrum of Li{sub 2}B{sub 3}O{sub 4}F{sub 3}. Highlights: Black-Right-Pointing-Pointer Characterisation of title compounds by solid-state {sup 11}B NMR spectroscopy. Black-Right-Pointing-Pointer Sub-spectra of boron species separated by evaluation of 3QMAS spectra. Black-Right-Pointing-Pointer Isotropic chemical shift and quadrupolar interaction parameters determined. Black-Right-Pointing-Pointer Full boron assignment based on NMR parameters and response to {sup 19}F decoupling.

  1. Enhancing Human and Planetary Health Through Innovation

    SciTech Connect (OSTI)

    Brown, Ben

    2014-10-17

    Ben Brown mesmerizes the audience on how to enhance human and planetary health through innovation at our '8 Big Ideas' Science at the Theater event on October 8th, 2014, in Oakland, California.

  2. HUMAN FACTORS GUIDANCE FOR CONTROL ROOM EVALUATION

    SciTech Connect (OSTI)

    OHARA,J.; BROWN,W.; STUBLER,W.; HIGGINS,J.; WACHTEL,J.; PERSENSKY,J.J.

    2000-07-30

    The Human-System Interface Design Review Guideline (NUREG-0700, Revision 1) was developed by the US Nuclear Regulatory Commission (NRC) to provide human factors guidance as a basis for the review of advanced human-system interface technologies. The guidance consists of three components: design review procedures, human factors engineering guidelines, and a software application to provide design review support called the ``Design Review Guideline.'' Since it was published in June 1996, Rev. 1 to NUREG-0700 has been used successfully by NRC staff, contractors and nuclear industry organizations, as well as by interested organizations outside the nuclear industry. The NRC has committed to the periodic update and improvement of the guidance to ensure that it remains a state-of-the-art design evaluation tool in the face of emerging and rapidly changing technology. This paper addresses the current research to update of NUREG-0700 based on the substantial work that has taken place since the publication of Revision 1.

  3. Implications of the Human Genome Project

    SciTech Connect (OSTI)

    Kitcher, P.

    1998-11-01

    The Human Genome Project (HGP), launched in 1991, aims to map and sequence the human genome by 2006. During the fifteen-year life of the project, it is projected that $3 billion in federal funds will be allocated to it. The ultimate aims of spending this money are to analyze the structure of human DNA, to identify all human genes, to recognize the functions of those genes, and to prepare for the biology and medicine of the twenty-first century. The following summary examines some of the implications of the program, concentrating on its scientific import and on the ethical and social problems that it raises. Its aim is to expose principles that might be used in applying the information which the HGP will generate. There is no attempt here to translate the principles into detailed proposals for legislation. Arguments and discussion can be found in the full report, but, like this summary, that report does not contain any legislative proposals.

  4. 2011-2015 Human Capital Management Plan

    Broader source: Energy.gov [DOE]

    The Office of Legacy Management (LM) needs skilled and engaged staff to accomplish our mission and carry out our responsibilities to the American people. This Human Capital Management Plan (HCMP or...

  5. 2016-2020 Strategic Human Capital Plan

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    the Chief Human Capital Officer 2016-2020 Strategic Human Capital Plan Cover Photo Description Beyond Double-Pane Windows While the invention of double-pane windows dates back to 1935, a true turning point in the technology came in the 1980s with a collaboration between the Department of Energy, private industry, and Lawrence Berkeley National Lab. Initial research and development by Berkeley Lab and a start-up company, Suntek Research Associates (now called Southwall Technologies), led to the

  6. Human Capital Accountability Program--Withdrawn

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2012-11-15

    Withdrawn 3-26-14. The purpose of maintaining and updating this directive is to (1) Ensure compliance with applicable laws, regulations, and other directives. (2) Reduce the risk of DOE losing any of its personnel authorities. (3) Incorporate functional accountability to ensure that Human Resource Directors' position descriptions and classifications are appropriate, selections result in quality leadership with skills needed, and performance plans and evaluations are consistent with Department and Administration human resources priorities and audit findings.

  7. A New Link Between Human and Bacterial Signaling Machinery

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A New Link Between Human and Bacterial Signaling Machinery A New Link Between Human and Bacterial Signaling Machinery Print Tuesday, 19 August 2014 10:34 The human immune system...

  8. Functional and Structural Characterization of Human V3-Specific...

    Office of Scientific and Technical Information (OSTI)

    Functional and Structural Characterization of Human V3-Specific Monoclonal Antibody 2424 ... Title: Functional and Structural Characterization of Human V3-Specific Monoclonal Antibody ...

  9. Microsoft PowerPoint - Crouther.HumanCapitalInitiatives.042909

    Office of Environmental Management (EM)

    Human Capital Initiatives Presented to the Environmental Management Advisory Board (EMAB) By Desi Crouther, Acting Director Office of Human Capital Office of Environmental Management ...

  10. Molecular details of a starch utilization pathway in the human...

    Office of Scientific and Technical Information (OSTI)

    pathway in the human gut symbiont Eubacterium rectale Citation Details In-Document Search Title: Molecular details of a starch utilization pathway in the human gut symbiont ...

  11. Crystal structure of the human [sigma]1 receptor (Journal Article...

    Office of Scientific and Technical Information (OSTI)

    Crystal structure of the human sigma1 receptor Citation Details In-Document Search Title: Crystal structure of the human sigma1 receptor Authors: Schmidt, Hayden R. ; Zheng, ...

  12. Response of Human Lung Epithelial Cells to Engineered Nanoparticles...

    Office of Scientific and Technical Information (OSTI)

    Response of Human Lung Epithelial Cells to Engineered Nanoparticles. Citation Details In-Document Search Title: Response of Human Lung Epithelial Cells to Engineered Nanoparticles. ...

  13. Xylan utilization in human gut commensal bacteria is orchestrated...

    Office of Scientific and Technical Information (OSTI)

    Xylan utilization in human gut commensal bacteria is orchestrated by unique modular ... Title: Xylan utilization in human gut commensal bacteria is orchestrated by unique modular ...

  14. Characterizing Loop Dynamics and Ligand Recognition in Human...

    Office of Scientific and Technical Information (OSTI)

    Characterizing Loop Dynamics and Ligand Recognition in Human- and Avian-Type Influenza ... Recognition in Human- and Avian-Type Influenza Neuraminidases via Generalized Born ...

  15. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic...

  16. UNDP-Human Development Reports | Open Energy Information

    Open Energy Info (EERE)

    Human Development Reports Jump to: navigation, search Tool Summary LAUNCH TOOL Name: UNDP-Human Development Reports AgencyCompany Organization: United Nations Development...

  17. Human Capital: The Role of Ombudsmen in Dispute Resolution

    Broader source: Energy.gov (indexed) [DOE]

    United States General Accounting Office GAO April 2001 HUMAN CAPITAL The Role of Ombudsmen ... Accounting Office GS General Schedule HR human resource IBB International Broadcasting ...

  18. Office of the Chief Human Capital Officer | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Office of the Chief Human Capital Officer Most Requested Benefits CHRIS (DOE Only) DOE & ... HR Contacts by Sub Agency Servicing Area HC Contacts by Functional Area Human Resource ...

  19. PIA - Savannah River Nuclear Solutions (SRNS) Human Resource...

    Broader source: Energy.gov (indexed) [DOE]

    (SRNS) Human Resource Management System (HRMS) PIA - Savannah River Nuclear Solutions (SRNS) Human Resource Management System (HRMS) (3.39 MB) More Documents & Publications PIA - ...

  20. 2014 Human Reliability Program Workshop Agenda | Department of...

    Broader source: Energy.gov (indexed) [DOE]

    September 17-19, 2014 2014 DOE Human Reliability Program Workshop And Webinar Agenda DOE ... 10 Code of Federal Regulations Part 712, Human Reliability Program INSPECTION REPORT: ...

  1. Manager's Desk Reference on Human Capital Management Flexibilities...

    Broader source: Energy.gov (indexed) [DOE]

    that can be used in day-to-day human capital management activities, especially ... Manager's Desk Reference on Human Capital Management Flexibilities (640.69 KB) Responsible ...

  2. Human Capital Policy Division (HC-11) | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Provide a full range of staff support to the Chief Human Capital Officer including support required for internal and external responsibilities. Develop and revise the agency human ...

  3. DOE Strategic Human Capital Plan | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    The current Strategic Human Capital Plan (SHCP) sets forth the framework for managing the Department of Energy's (DOE) human capital system through 2020. This Plan, which replaces ...

  4. First Steps Toward Tribal Weatherization - Human Capacity Development...

    Broader source: Energy.gov (indexed) [DOE]

    Toward Tribal Weatherization - Human Capacity Development (DE-PA36-09GO99022) 2006 All ... Weatherization Training Program Phase 1: Development of human capacity to deliver ...

  5. Office of the Chief Human Capital Officer (HC-1) | Department...

    Broader source: Energy.gov (indexed) [DOE]

    HC-1 Mission and Function Statement The Office of the Chief Human Capital Officer (HC) ... agreementsrelationships related to all aspects of Human Capital Management (HCM). ...

  6. DOE Jobs Online (Hiring Manager), Office of Human Capitol Management...

    Broader source: Energy.gov (indexed) [DOE]

    Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and Solutions DOE Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and ...

  7. Office of Human Resource Services (HC-30) | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    This organization provides a full range of human capital management (HCM) operational ... Leadership Rita M. Clinton Director, Office of Human Resource Services Read Bio HC-30 ...

  8. Yurok Tribe - Tribal Utility Project and Human Capacity Building

    Broader source: Energy.gov (indexed) [DOE]

    Study (completed June 30, 2007) 2. Human Capacity Building in Energy Efficiency and ... Facility (QF) Possible Grant Funding Human Capacity Building Project Project Team ...

  9. Human Resources at Ames Laboratory | Critical Materials Institute

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Contact Information Contact information for Human Resources staff within The Ames Laboratory. Human Resources Office 105 TASF 515-294-2680 Diane Muncrief Manager Labor Relations - ...

  10. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic ...

  11. Neutrons provide new insights into human cell behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Neutrons provide new insights into human cell behavior Community Connections: Your link to ... All Issues submit Neutrons provide new insights into human cell behavior Physics and ...

  12. COLLOQUIUM: The Power of Neuroplasticity: Enhancing Human Potential...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    COLLOQUIUM: The Power of Neuroplasticity: Enhancing Human Potential Dr. Paula Tallal ... designed based on research findings from human and animal research and translated into ...

  13. Antibody library project could unlock mysteries of human gene...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mysteries of human gene function Antibody library project could unlock mysteries of human gene function By looking at antibodies, researchers can identify where, in a cell, genes ...

  14. Molecular clocks control mutation rate in human cells

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Molecular clocks control mutation rate in human cells Molecular clocks control mutation rate in human cells These clock-like mutational processes could ultimately be responsible ...

  15. Hand-Held Analyzer Quickly Detects Buried Human Remains - Energy...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hand-Held Analyzer Quickly Detects Buried Human Remains Oak Ridge National Laboratory ... and auditory cues to quickly alert investigators to the presence of buried human remains. ...

  16. Scientists call for antibody 'bar code' system to follow Human...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Scientists call for antibody 'bar code' system to follow Human Genome Project Researchers ... on the scale of the now-completed Human Genome Project. (Image: Public Domain, ...

  17. Modeling and Simulation of Human Behavior in Buildings

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Laboratory Modeling and Simulation of Human Behavior in Buildings 2015 Building ... to IEA EBC Annex 66 4 Complexity of Human Behavior * Inherent uncertainty * ...

  18. River Corridor Baseline Risk Assessment (RCBRA) Human Health...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    12, 2011 River Corridor Baseline Risk Assessment (RCBRA) Human Health Risk Assessment (Volume 2) * RCBRA Human Health Risk Assessment is final - Response provided to HAB ...

  19. Structure of Human Argonaute2: A Programmable Ribonuclease |...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Argonaute2: A Programmable Ribonuclease Wednesday, July 31, 2013 Ribonucleases ... Institute were able to solve the three-dimensional structure of human Argonaute2 (Fig 1A). ...

  20. "OUT OF AFRICA: GENETICS AND HUMAN MIGRATIONS", Prof. Gyan Bhanot...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    "OUT OF AFRICA: GENETICS AND HUMAN MIGRATIONS", Prof. Gyan Bhanot, Department of Molecular Biology, Biochemistry and Physics, Rutgers University OUT OF AFRICA: GENETICS AND HUMAN ...

  1. Neutrons provide new insights into human cell behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Neutrons provide new insights into human cell behavior Alumni Link: Opportunities, News ... All Issues submit Neutrons provide new insights into human cell behavior Physics and ...

  2. Human Factors Engineering Analysis Tool - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Factors Engineering Analysis Tool Software tool that enables easy and quick selection of applicable regulatory guidelines as starting point for human factors engineering ...

  3. Scientists call for antibody 'bar code' system to follow Human...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Scientists call for antibody 'bar code' system to follow Human Genome Project Alumni Link: ... Scientists call for antibody 'bar code' system to follow Human Genome Project Researchers ...

  4. Human Resources | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources Integrated Support Center (ISC) ISC Home About Services Freedom of ... Services Human Resources Print Text Size: A A A FeedbackShare Page Related Links Forms ...

  5. The Oak Ridge Institute for Science and Education Human Subjects...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Subjects Research Program PrivacySecurity Statement Contact | Forms PurposeMission ... The Oak Ridge Institute for Science and Education (ORISE) Human Subjects Research Program ...

  6. Structure of the human M2 muscarinic acetylcholine receptor bound...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist Citation Details In-Document Search Title: Structure of the human M2 muscarinic acetylcholine ...

  7. Stories of Discovery & Innovation: From Human Genome to Materials...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    From Human Genome to Materials "Genome" Energy Frontier Research Centers (EFRCs) EFRCs ... Stories of Discovery & Innovation: From Human Genome to Materials "Genome" Print Text ...

  8. Fossil analysis pushes back human split from other primates by...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fossil analysis pushes back human split from other primates Fossil analysis pushes back human split from other primates by two million years C. abyssinicus revealed answers about ...

  9. Human Subjects Protection Program Homepage | U.S. DOE Office...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HSPP Home Human Subjects Protection Program (HSPP) HSPP Home About Institutional Review ... Contact BER Home Contact Information Human Subjects Protection Program U.S. ...

  10. Human immunodeficiency virus type 1 clade M mosaic gag polypeptides...

    Office of Scientific and Technical Information (OSTI)

    Patent: Human immunodeficiency virus type 1 clade M mosaic gag polypeptides Citation Details In-Document Search Title: Human immunodeficiency virus type 1 clade M mosaic gag ...

  11. Mapping and Sequencing the Human Genome

    DOE R&D Accomplishments [OSTI]

    1988-01-01

    Numerous meetings have been held and a debate has developed in the biological community over the merits of mapping and sequencing the human genome. In response a committee to examine the desirability and feasibility of mapping and sequencing the human genome was formed to suggest options for implementing the project. The committee asked many questions. Should the analysis of the human genome be left entirely to the traditionally uncoordinated, but highly successful, support systems that fund the vast majority of biomedical research. Or should a more focused and coordinated additional support system be developed that is limited to encouraging and facilitating the mapping and eventual sequencing of the human genome. If so, how can this be done without distorting the broader goals of biological research that are crucial for any understanding of the data generated in such a human genome project. As the committee became better informed on the many relevant issues, the opinions of its members coalesced, producing a shared consensus of what should be done. This report reflects that consensus.

  12. A technique for human error analysis (ATHEANA)

    SciTech Connect (OSTI)

    Cooper, S.E.; Ramey-Smith, A.M.; Wreathall, J.; Parry, G.W.

    1996-05-01

    Probabilistic risk assessment (PRA) has become an important tool in the nuclear power industry, both for the Nuclear Regulatory Commission (NRC) and the operating utilities. Human reliability analysis (HRA) is a critical element of PRA; however, limitations in the analysis of human actions in PRAs have long been recognized as a constraint when using PRA. A multidisciplinary HRA framework has been developed with the objective of providing a structured approach for analyzing operating experience and understanding nuclear plant safety, human error, and the underlying factors that affect them. The concepts of the framework have matured into a rudimentary working HRA method. A trial application of the method has demonstrated that it is possible to identify potentially significant human failure events from actual operating experience which are not generally included in current PRAs, as well as to identify associated performance shaping factors and plant conditions that have an observable impact on the frequency of core damage. A general process was developed, albeit in preliminary form, that addresses the iterative steps of defining human failure events and estimating their probabilities using search schemes. Additionally, a knowledge- base was developed which describes the links between performance shaping factors and resulting unsafe actions.

  13. Ontology-enriched Visualization of Human Anatomy

    SciTech Connect (OSTI)

    Pouchard, LC

    2005-12-20

    The project focuses on the problem of presenting a human anatomical 3D model associated with other types of human systemic information ranging from physiological to anatomical information while navigating the 3D model. We propose a solution that integrates a visual 3D interface and navigation features with the display of structured information contained in an ontology of anatomy where the structures of the human body are formally and semantically linked. The displayed and annotated anatomy serves as a visual entry point into a patient's anatomy, medical indicators and other information. The ontology of medical information provides labeling to the highlighted anatomical parts in the 3D display. Because of the logical organization and links between anatomical objects found in the ontology and associated 3D model, the analysis of a structure by a physician is greatly enhanced. Navigation within the 3D visualization and between this visualization and objects representing anatomical concepts within the model is also featured.

  14. Human factors in nuclear technology - a history

    SciTech Connect (OSTI)

    Jones, D.B. )

    1992-01-01

    Human factors, human factors engineering (HFE), or ergonomics did not receive much formal attention in nuclear technology prior to the Three Mile Island Unit 2 (TMI-2) incident. Three principal reasons exist for this lack of concern. First, emerging technologies show little concern with how people will use a new system. Making the new technology work is considered more important than the people who will use it. Second, the culture of the users of nuclear power did not recognize a need for human factors. Traditional utilities had well established and effective engineering designs for control of electric power generation, while medicine considered the use of nuclear isotopes another useful tool, not requiring special ergonomics. Finally, the nuclear industry owed much to Admiral Rickover. He was definitely opposed.

  15. Human-mouse comparative genomics: successes and failures to reveal functional regions of the human genome

    SciTech Connect (OSTI)

    Pennacchio, Len A.; Baroukh, Nadine; Rubin, Edward M.

    2003-05-15

    Deciphering the genetic code embedded within the human genome remains a significant challenge despite the human genome consortium's recent success at defining its linear sequence (Lander et al. 2001; Venter et al. 2001). While useful strategies exist to identify a large percentage of protein encoding regions, efforts to accurately define functional sequences in the remaining {approx}97 percent of the genome lag. Our primary interest has been to utilize the evolutionary relationship and the universal nature of genomic sequence information in vertebrates to reveal functional elements in the human genome. This has been achieved through the combined use of vertebrate comparative genomics to pinpoint highly conserved sequences as candidates for biological activity and transgenic mouse studies to address the functionality of defined human DNA fragments. Accordingly, we describe strategies and insights into functional sequences in the human genome through the use of comparative genomics coupled wit h functional studies in the mouse.

  16. Annotated bibliography of human factors applications literature

    SciTech Connect (OSTI)

    McCafferty, D.B.

    1984-09-30

    This bibliography was prepared as part of the Human Factors Technology Project, FY 1984, sponsored by the Office of Nuclear Safety, US Department of Energy. The project was conducted by Lawrence Livermore National Laboratory, with Essex Corporation as a subcontractor. The material presented here is a revision and expansion of the bibliographic material developed in FY 1982 as part of a previous Human Factors Technology Project. The previous bibliography was published September 30, 1982, as Attachment 1 to the FY 1982 Project Status Report.

  17. Protection of Human Subjects in Classified Research

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2016-01-21

    This notice supplements DOE O 443.1B and 10 CFR Part 745 by addressing the Department of Energy (DOE)-specific requirements for the protection of human subjects involved in research that is classified, in whole or in part.

  18. Report on the Human Genome Initiative

    SciTech Connect (OSTI)

    Tinoco, I.; Cahill, G.; Cantor, C.; Caskey, T.; Dulbecco, R.; Engelhardt, D. L.; Hood, L.; Lerman, L. S.; Mendelsohn, M. L.; Sinsheimer, R. L.; Smith, T.; Soll, D.; Stormo, G.; White, R. L.

    1987-04-01

    The report urges DOE and the Nation to commit to a large. multi-year. multidisciplinary. technological undertaking to order and sequence the human genome. This effort will first require significant innovation in general capability to manipulate DNA. major new analytical methods for ordering and sequencing. theoretical developments in computer science and mathematical biology, and great expansions in our ability to store and manipulate the information and to interface it with other large and diverse genetic databases. The actual ordering and sequencing involves the coordinated processing of some 3 billion bases from a reference human genome. Science is poised on the rudimentary edge of being able to read and understand human genes. A concerted. broadly based. scientific effort to provide new methods of sufficient power and scale should transform this activity from an inefficient one-gene-at-a-time. single laboratory effort into a coordinated. worldwide. comprehensive reading of "the book of man". The effort will be extraordinary in scope and magnitude. but so will be the benefit to biological understanding. new technology and the diagnosis and treatment of human disease.

  19. Human Health Science Building Geothermal Heat Pumps

    Broader source: Energy.gov [DOE]

    Project objectives: Construct a ground sourced heat pump, heating, ventilation, and air conditioning system for the new Oakland University Human Health Sciences Building utilizing variable refrigerant flow (VRF) heat pumps. A pair of dedicated outdoor air supply units will utilize a thermally regenerated desiccant dehumidification section. A large solar thermal system along with a natural gas backup boiler will provide the thermal regeneration energy.

  20. Top-down and bottom-up definitions of human failure events in human reliability analysis

    SciTech Connect (OSTI)

    Boring, Ronald Laurids

    2014-10-01

    In the probabilistic risk assessments (PRAs) used in the nuclear industry, human failure events (HFEs) are determined as a subset of hardware failures, namely those hardware failures that could be triggered by human action or inaction. This approach is top-down, starting with hardware faults and deducing human contributions to those faults. Elsewhere, more traditionally human factors driven approaches would tend to look at opportunities for human errors first in a task analysis and then identify which of those errors is risk significant. The intersection of top-down and bottom-up approaches to defining HFEs has not been carefully studied. Ideally, both approaches should arrive at the same set of HFEs. This question is crucial, however, as human reliability analysis (HRA) methods are generalized to new domains like oil and gas. The HFEs used in nuclear PRAs tend to be top-down—defined as a subset of the PRA—whereas the HFEs used in petroleum quantitative risk assessments (QRAs) often tend to be bottom-up—derived from a task analysis conducted by human factors experts. The marriage of these approaches is necessary in order to ensure that HRA methods developed for top-down HFEs are also sufficient for bottom-up applications.

  1. Project ATHENA Creates Surrogate Human Organ Systems

    SciTech Connect (OSTI)

    MacQueen, Luke; Knospel, Fanny; Sherrod, Stacy; Iyer, Rashi

    2015-06-15

    The development of miniature surrogate human organs, coupled with highly sensitive mass spectrometry technologies, could one day revolutionize the way new drugs and toxic agents are studied. “By developing this ‘homo minutus,’ we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs,” said Rashi Iyer, a senior scientist at Los Alamos National Laboratory. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is nearing the full integration of four human organ constructs — liver, heart, lung and kidney — each organ component is about the size of a smartphone screen, and the whole ATHENA “body” of interconnected organs will fit neatly on a desk. A new video available on the Los Alamos National Laboratory YouTube channel updates the ATHENA project as it begins to integrate the various organ systems into a single system (link to video here). Some 40 percent of pharmaceuticals fail their clinical trials and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success. ATHENA is funded by the Defense Threat Reduction Agency (DTRA) and is a collaboration of Los Alamos National Laboratory, Harvard University, Vanderbilt University, Charité Universitätsmedizin, Berlin, Germany, CFD Research Corporation, and the University of California San Francisco.

  2. New Employee Orientation - Forms Checklist | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Forms Checklist New Employee Orientation - Forms Checklist Listing of the forms to be issued and collected at a new employee's orientation. Please review the checklist to ensure that you bring all of the needed forms. NEO - Forms Checklist (379.74 KB) More Documents & Publications New Employee Orientation - Ethics Briefing Certification Rights and Benefits of Reservists Called to Active Duty Handbook on Overseas Assignments

  3. HSI Prototypes for Human Systems Simulation Laboratory

    SciTech Connect (OSTI)

    Jokstad, Håkon; McDonald, Rob

    2015-09-01

    This report describes in detail the design and features of three Human System Interface (HSI) prototypes developed by the Institutt for Energiteknikk (IFE) in support of the U.S. Department of Energy’s Light Water Reactor Sustainability Program under Contract 128420 through Idaho National Laboratory (INL). The prototypes are implemented for the Generic Pressurized Water Reactor simulator and installed in the Human Systems Simulation Laboratory at INL. The three prototypes are: 1) Power Ramp display 2) RCS Heat-up and Cool-down display 3) Estimated time to limit display The power ramp display and the RCS heat-up/cool-down display are designed to provide good visual indications to the operators on how well they are performing their task compared to their target ramp/heat-up/cool-down rate. The estimated time to limit display is designed to help operators restore levels or pressures before automatic or required manual actions are activated.

  4. Bridging Resilience Engineering and Human Reliability Analysis

    SciTech Connect (OSTI)

    Ronald L. Boring

    2010-06-01

    There has been strong interest in the new and emerging field called resilience engineering. This field has been quick to align itself with many existing safety disciplines, but it has also distanced itself from the field of human reliability analysis. To date, the discussion has been somewhat one-sided, with much discussion about the new insights afforded by resilience engineering. This paper presents an attempt to address resilience engineering from the perspective of human reliability analysis (HRA). It is argued that HRA shares much in common with resilience engineering and that, in fact, it can help strengthen nascent ideas in resilience engineering. This paper seeks to clarify and ultimately refute the arguments that have served to divide HRA and resilience engineering.

  5. Justice and the Human Genome Project

    SciTech Connect (OSTI)

    Murphy, T.F.; Lappe, M.

    1992-01-01

    Most of the essays gathered in this volume were first presented at a conference, Justice and the Human Genome, in Chicago in early November, 1991. The goal of the, conference was to consider questions of justice as they are and will be raised by the Human Genome Project. To achieve its goal of identifying and elucidating the challenges of justice inherent in genomic research and its social applications the conference drew together in one forum members from academia, medicine, and industry with interests divergent as rate-setting for insurance, the care of newborns, and the history of ethics. The essays in this volume address a number of theoretical and practical concerns relative to the meaning of genomic research.

  6. Justice and the Human Genome Project

    SciTech Connect (OSTI)

    Murphy, T.F.; Lappe, M.

    1992-12-31

    Most of the essays gathered in this volume were first presented at a conference, Justice and the Human Genome, in Chicago in early November, 1991. The goal of the, conference was to consider questions of justice as they are and will be raised by the Human Genome Project. To achieve its goal of identifying and elucidating the challenges of justice inherent in genomic research and its social applications the conference drew together in one forum members from academia, medicine, and industry with interests divergent as rate-setting for insurance, the care of newborns, and the history of ethics. The essays in this volume address a number of theoretical and practical concerns relative to the meaning of genomic research.

  7. Justice and the human genome project

    SciTech Connect (OSTI)

    Murphy, T.F.; Lappe, M.A.

    1995-04-01

    This book is a collection of nine essays originally presented at a conference entitled {open_quotes}Justice and the Human Genome{close_quotes} held in Chicago in late 1991. The goal of the articles in this collection is to explore questions of justice raised by developments in genomic research and by applications of genetic knowledge and technology. The Human Genome Project (HGP) is used as a starting point for exploring these questions, but, as Marc Lappe recognizes, the database generated by HGP research will have implications far beyond the medical applications frequently used to justify this research effort. Thus, the book`s contributors consider questions of justice in relation to screening and testing for various predispositions, conditions, and diseases and gene therapy but also examine testing for other characteristics, forensic uses of genetic information, issues associated with DNA banks, and (hypothetical) genetic enhancement possibilities.

  8. Human Reliability Analysis for Small Modular Reactors

    SciTech Connect (OSTI)

    Ronald L. Boring; David I. Gertman

    2012-06-01

    Because no human reliability analysis (HRA) method was specifically developed for small modular reactors (SMRs), the application of any current HRA method to SMRs represents tradeoffs. A first- generation HRA method like THERP provides clearly defined activity types, but these activity types do not map to the human-system interface or concept of operations confronting SMR operators. A second- generation HRA method like ATHEANA is flexible enough to be used for SMR applications, but there is currently insufficient guidance for the analyst, requiring considerably more first-of-a-kind analyses and extensive SMR expertise in order to complete a quality HRA. Although no current HRA method is optimized to SMRs, it is possible to use existing HRA methods to identify errors, incorporate them as human failure events in the probabilistic risk assessment (PRA), and quantify them. In this paper, we provided preliminary guidance to assist the human reliability analyst and reviewer in understanding how to apply current HRA methods to the domain of SMRs. While it is possible to perform a satisfactory HRA using existing HRA methods, ultimately it is desirable to formally incorporate SMR considerations into the methods. This may require the development of new HRA methods. More practicably, existing methods need to be adapted to incorporate SMRs. Such adaptations may take the form of guidance on the complex mapping between conventional light water reactors and small modular reactors. While many behaviors and activities are shared between current plants and SMRs, the methods must adapt if they are to perform a valid and accurate analysis of plant personnel performance in SMRs.

  9. Individual Differences in Human Reliability Analysis

    SciTech Connect (OSTI)

    Jeffrey C. Joe; Ronald L. Boring

    2014-06-01

    While human reliability analysis (HRA) methods include uncertainty in quantification, the nominal model of human error in HRA typically assumes that operator performance does not vary significantly when they are given the same initiating event, indicators, procedures, and training, and that any differences in operator performance are simply aleatory (i.e., random). While this assumption generally holds true when performing routine actions, variability in operator response has been observed in multiple studies, especially in complex situations that go beyond training and procedures. As such, complexity can lead to differences in operator performance (e.g., operator understanding and decision-making). Furthermore, psychological research has shown that there are a number of known antecedents (i.e., attributable causes) that consistently contribute to observable and systematically measurable (i.e., not random) differences in behavior. This paper reviews examples of individual differences taken from operational experience and the psychological literature. The impact of these differences in human behavior and their implications for HRA are then discussed. We propose that individual differences should not be treated as aleatory, but rather as epistemic. Ultimately, by understanding the sources of individual differences, it is possible to remove some epistemic uncertainty from analyses.

  10. Monoamine oxidase: Radiotracer chemistry and human studies

    SciTech Connect (OSTI)

    Fowler, Joanna S.; Logan, Jean; Shumay, Elena; Alia-Klein, Nelly; Wang, Gene-Jack; Volkow, Nora D.

    2015-03-01

    Monoamine oxidase (MAO) oxidizes amines from both endogenous and exogenous sources thereby regulating the concentration of neurotransmitter amines such as serot onin, norepinephrine and dopamine as well as many xenobiotics. MAO inhibitor drugs are used in the treatment of Parkinsons disease and in depression stimulating the development of radiotracer tools to probe the role of MAO in normal human biology and in disease. Over the past 30 since the first radiotracers were developed and the first PET images of MAO in humans were carried out, PET studies of brain MAO in healthy volunteers and in patients have identified different variables which have contributed to different MAO levels in brain and in peripheral organs. MAO radiotracers and PET have also been used to study the current and developing MAO inhibitor drugs including the selection of doses for clinical trials. In this article, we describe (1) the development of MAO radiotracers; (2) human studies including the relationship of brain MAO levels to genotype, personality, neurological and psychiatric disorders; (3) examples of the use of MAO radiotracers in drug research and development. We will conclude with outstanding needs to improve the radiotracers which are currently used and possible new applications.

  11. Monoamine oxidase: Radiotracer chemistry and human studies

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Fowler, Joanna S.; Logan, Jean; Shumay, Elena; Alia-Klein, Nelly; Wang, Gene-Jack; Volkow, Nora D.

    2015-03-01

    Monoamine oxidase (MAO) oxidizes amines from both endogenous and exogenous sources thereby regulating the concentration of neurotransmitter amines such as serot onin, norepinephrine and dopamine as well as many xenobiotics. MAO inhibitor drugs are used in the treatment of Parkinson’s disease and in depression stimulating the development of radiotracer tools to probe the role of MAO in normal human biology and in disease. Over the past 30 since the first radiotracers were developed and the first PET images of MAO in humans were carried out, PET studies of brain MAO in healthy volunteers and in patients have identified different variablesmore » which have contributed to different MAO levels in brain and in peripheral organs. MAO radiotracers and PET have also been used to study the current and developing MAO inhibitor drugs including the selection of doses for clinical trials. In this article, we describe (1) the development of MAO radiotracers; (2) human studies including the relationship of brain MAO levels to genotype, personality, neurological and psychiatric disorders; (3) examples of the use of MAO radiotracers in drug research and development. We will conclude with outstanding needs to improve the radiotracers which are currently used and possible new applications.« less

  12. Monoamine oxidase: Radiotracer chemistry and human studies

    SciTech Connect (OSTI)

    Fowler, Joanna S.; Logan, Jean; Shumay, Elena; Alia-Klein, Nelly; Wang, Gene-Jack; Volkow, Nora D.

    2015-03-01

    Monoamine oxidase (MAO) oxidizes amines from both endogenous and exogenous sources thereby regulating the concentration of neurotransmitter amines such as serot onin, norepinephrine and dopamine as well as many xenobiotics. MAO inhibitor drugs are used in the treatment of Parkinson’s disease and in depression stimulating the development of radiotracer tools to probe the role of MAO in normal human biology and in disease. Over the past 30 since the first radiotracers were developed and the first PET images of MAO in humans were carried out, PET studies of brain MAO in healthy volunteers and in patients have identified different variables which have contributed to different MAO levels in brain and in peripheral organs. MAO radiotracers and PET have also been used to study the current and developing MAO inhibitor drugs including the selection of doses for clinical trials. In this article, we describe (1) the development of MAO radiotracers; (2) human studies including the relationship of brain MAO levels to genotype, personality, neurological and psychiatric disorders; (3) examples of the use of MAO radiotracers in drug research and development. We will conclude with outstanding needs to improve the radiotracers which are currently used and possible new applications.

  13. Human-system Interfaces for Automatic Systems

    SciTech Connect (OSTI)

    OHara, J.M.; Higgins,J.; Fleger, S.; Barnes V.

    2010-11-07

    Automation is ubiquitous in modern complex systems, and commercial nuclear- power plants are no exception. Automation is applied to a wide range of functions including monitoring and detection, situation assessment, response planning, and response implementation. Automation has become a 'team player' supporting personnel in nearly all aspects of system operation. In light of its increasing use and importance in new- and future-plants, guidance is needed to conduct safety reviews of the operator's interface with automation. The objective of this research was to develop such guidance. We first characterized the important HFE aspects of automation, including six dimensions: levels, functions, processes, modes, flexibility, and reliability. Next, we reviewed literature on the effects of all of these aspects of automation on human performance, and on the design of human-system interfaces (HSIs). Then, we used this technical basis established from the literature to identify general principles for human-automation interaction and to develop review guidelines. The guidelines consist of the following seven topics: automation displays, interaction and control, automation modes, automation levels, adaptive automation, error tolerance and failure management, and HSI integration. In addition, our study identified several topics for additional research.

  14. Measuring the maturity of a technology : guidance on assigning...

    Office of Scientific and Technical Information (OSTI)

    Risk is reduced in system acquisition by selecting mature technologies for inclusion in system development. TRLs are used to assess the maturity of evolving technologies...

  15. Assigning protein functions by comparative genome analysis protein phylogenetic profiles

    DOE Patents [OSTI]

    Pellegrini, Matteo; Marcotte, Edward M.; Thompson, Michael J.; Eisenberg, David; Grothe, Robert; Yeates, Todd O.

    2003-05-13

    A computational method system, and computer program are provided for inferring functional links from genome sequences. One method is based on the observation that some pairs of proteins A' and B' have homologs in another organism fused into a single protein chain AB. A trans-genome comparison of sequences can reveal these AB sequences, which are Rosetta Stone sequences because they decipher an interaction between A' and B. Another method compares the genomic sequence of two or more organisms to create a phylogenetic profile for each protein indicating its presence or absence across all the genomes. The profile provides information regarding functional links between different families of proteins. In yet another method a combination of the above two methods is used to predict functional links.

  16. Management Alert - Extended Assignments at Princeton Plasma Physics...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... MANAGEMENT REACTION AND AUDITOR COMMENTS The Office of Management concurred with our ... have been helpful? 5. Please include your name and telephone number so that we may ...

  17. Preliminary Framework for Human-Automation Collaboration

    SciTech Connect (OSTI)

    Oxstrand, Johanna Helene; Le Blanc, Katya Lee; Spielman, Zachary Alexander

    2015-09-01

    The Department of Energy’s Advanced Reactor Technologies Program sponsors research, development and deployment activities through its Next Generation Nuclear Plant, Advanced Reactor Concepts, and Advanced Small Modular Reactor (aSMR) Programs to promote safety, technical, economical, and environmental advancements of innovative Generation IV nuclear energy technologies. The Human Automation Collaboration (HAC) Research Project is located under the aSMR Program, which identifies developing advanced instrumentation and controls and human-machine interfaces as one of four key research areas. It is expected that the new nuclear power plant designs will employ technology significantly more advanced than the analog systems in the existing reactor fleet as well as utilizing automation to a greater extent. Moving towards more advanced technology and more automation does not necessary imply more efficient and safer operation of the plant. Instead, a number of concerns about how these technologies will affect human performance and the overall safety of the plant need to be addressed. More specifically, it is important to investigate how the operator and the automation work as a team to ensure effective and safe plant operation, also known as the human-automation collaboration (HAC). The focus of the HAC research is to understand how various characteristics of automation (such as its reliability, processes, and modes) effect an operator’s use and awareness of plant conditions. In other words, the research team investigates how to best design the collaboration between the operators and the automated systems in a manner that has the greatest positive impact on overall plant performance and reliability. This report addresses the Department of Energy milestone M4AT-15IN2302054, Complete Preliminary Framework for Human-Automation Collaboration, by discussing the two phased development of a preliminary HAC framework. The framework developed in the first phase was used as the

  18. Human System Simulation in Support of Human Performance Technical Basis at NPPs

    SciTech Connect (OSTI)

    David Gertman; Katya Le Blanc; alan mecham; william phoenix; Magdy Tawfik; Jeffrey Joe

    2010-06-01

    This paper focuses on strategies and progress toward establishing the Idaho National Laboratorys (INLs) Human Systems Simulator Laboratory at the Center for Advanced Energy Studies (CAES), a consortium of Idaho State Universities. The INL is one of the National Laboratories of the US Department of Energy. One of the first planned applications for the Human Systems Simulator Laboratory is implementation of a dynamic nuclear power plant simulation (NPP) where studies of operator workload, situation awareness, performance and preference will be carried out in simulated control rooms including nuclear power plant control rooms. Simulation offers a means by which to review operational concepts, improve design practices and provide a technical basis for licensing decisions. In preparation for the next generation power plant and current government and industry efforts in support of light water reactor sustainability, human operators will be attached to a suite of physiological measurement instruments and, in combination with traditional Human Factors Measurement techniques, carry out control room tasks in simulated advanced digital and hybrid analog/digital control rooms. The current focus of the Human Systems Simulator Laboratory is building core competence in quantitative and qualitative measurements of situation awareness and workload. Of particular interest is whether introduction of digital systems including automated procedures has the potential to reduce workload and enhance safety while improving situation awareness or whether workload is merely shifted and situation awareness is modified in yet to be determined ways. Data analysis is carried out by engineers and scientists and includes measures of the physical and neurological correlates of human performance. The current approach supports a user-centered design philosophy (see ISO 13407 Human Centered Design Process for Interactive Systems, 1999) wherein the context for task performance along with the

  19. UC 9-8-309 - Human Remains | Open Energy Information

    Open Energy Info (EERE)

    9 - Human Remains Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: UC 9-8-309 - Human RemainsLegal Abstract Governs discovery of...

  20. RCW - 68.50 Human Remains | Open Energy Information

    Open Energy Info (EERE)

    68.50 Human Remains Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: RCW - 68.50 Human RemainsLegal Published NA Year...

  1. PIA - Human Resources System/Payroll System | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    SystemPayroll System PIA - Human Resources SystemPayroll System (291.51 KB) More Documents & Publications PIA - INL PeopleSoft - Human Resource System PIA - INL SECURITY ...

  2. Office of Executive Resources Office of the Chief Human Capital...

    Broader source: Energy.gov (indexed) [DOE]

    Office of Executive Resources Office of the Chief Human Capital Officer U.S. Department of ... The request must be submitted to the Office of the Chief Human Capital Officer, Office of ...

  3. Office of Executive Resources Office of the Chief Human Capital...

    Broader source: Energy.gov (indexed) [DOE]

    Office of Executive Resources Office of the Chief Human Capital Officer U.S. Department of ... Chief Human Capital Officer (CHCO) and Office of Executive Resources (OER). (1) Develop ...

  4. The Crystal Structure of Human, Nicotine Metabolizing Cytochrome...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Crystal Structure of Human, Nicotine Metabolizing Cytochrome P450 2A6 J.K. Yano1, ... The human cytochrome P450 2A6 is principally involved in the break down of nicotine in the ...

  5. Short-term Human Vision Protection from Intense Light Sources...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Short-term Human Vision Protection from Intense Light Sources The primary objective of this invention is to minimize the sensitivity of the human eye to intense visible light by ...

  6. Consortium to design human trials of mosaic HIV vaccine

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human trials of mosaic HIV vaccine Consortium to design human trials of mosaic HIV vaccine The vaccine represents a novel strategy for fighting the virus that causes AIDS by ...

  7. BigNeuron: Unlocking the Secrets of the Human Brain

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    BigNeuron: Unlocking the Secrets of the Human Brain BigNeuron: Unlocking the Secrets of the Human Brain Berkeley Researchers and Supercomputers to Help Create a Standard 3D Neuron ...

  8. COLLOQUIUM: Human Impacts on the Earth's Geologic Carbon Cycle...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    January 15, 2014, 4:00pm to 5:30pm Colloquia MBG Auditorium COLLOQUIUM: Human Impacts on ... Human Impacts on the Earth's Geologic Carbon Cycle Colloquium Committee: The Princeton ...

  9. Changes in Delegations of Authority from the Office of Human...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    from the Office of Human Capital Management by Jim McDonald Rescinds specific delegation orders that are rescinded as a result of the restructuring of the human capital function ...

  10. Human Resources at Colorado School of Mines | Critical Materials...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Employment at Colorado School of Mines Office of Human Resources: 1500 Illinois St., Suite ... Assistant Director (303)-273-3056 Link to Office of Human Resources Link to Job Openings

  11. What Is the Relationship of Electricity and the Human Body? ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Is the Relationship of Electricity and the Human Body? Click to email this to a friend ... What Is the Relationship of Electricity and the Human Body? 2012.05.30 Chief Scientist Jim ...

  12. ATHENA desktop human "body" could reduce need for animal drug...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ATHENA could reduce need for animal drug tests ATHENA desktop human "body" could reduce need for animal drug tests ATHENA project team is developing four human organ constructs that ...

  13. OMB 1910-5122, Human Reliability Program - Description of Collections |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy OMB 1910-5122, Human Reliability Program - Description of Collections OMB 1910-5122, Human Reliability Program - Description of Collections Human Reliability Program Certification (DOE F 470.3). Under the Department of Energy Human Reliability Program (HRP), individuals who are applicants for or incumbents in designated positions must be evaluated to ensure that they meet the requirements for certification in the program. This form documents that each part of the

  14. Chesapeake Habitat for Humanity: Affordable Housing Case Study

    SciTech Connect (OSTI)

    2006-08-28

    This case study describes a partnership with Chesapeake Habitat for Humanity to renovate five Baltimore historic rowhouses.

  15. Human Behavior, Standards and Tools to Improve Design & Operation |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Human Behavior, Standards and Tools to Improve Design & Operation Human Behavior, Standards and Tools to Improve Design & Operation Three steps of the technical approach to the human energy behavior loop: (1) Investigate the operations of building energy and services systems through behavior-related data collection, (2) Understand the human behavior through data analytics, data mining, and modeling, and (3) Improve the building performance by applying behavioral

  16. Global environmental change: Modifying human contributions through education

    SciTech Connect (OSTI)

    Carter, L.M.

    1997-12-31

    The 1995 Intergovernmental Panel on Climate Change (IPCC) Science report concludes that evidence now available {open_quotes}points toward a discernible human influence on global climate{close_quotes}. Reductions in emissions will require changes in human behavior. Knowledge, often through education, is an important moderator of human environmental behavior. This study assessed whether gains in global environmental change knowledge would lead to changes in human behaviors that could be deemed environmentally responsible.

  17. DOE Jobs Online (Hiring Manager), Office of Human Capitol Management

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Innovation and Solutions | Department of Energy Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and Solutions DOE Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and Solutions DOE Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and Solutions DOE Jobs Online (Hiring Manager), Office of Human Capitol Management Innovation and Solutions (1.46 MB) More Documents & Publications PIA - GovTrip (DOE data) LM

  18. Human Portable Radiation Detection System Communications Package Evaluation

    SciTech Connect (OSTI)

    Morgen, Gerald P.; Peterson, William W.

    2009-06-11

    Testing and valuation of the Human Portable Radiation Detection System Communications Package for the US Coast Guard.

  19. Case Study: Southeast Volusia Habitat for Humanity | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Southeast Volusia Habitat for Humanity Case Study: Southeast Volusia Habitat for Humanity Case Study: Southeast Volusia Habitat for Humanity In August 2013, Southeast Volusia County Habitat for Humanity (Volusia Habitat) completed its first U.S. Department of Energy (DOE) Zero Energy Ready Home in Edgewater, on the Atlantic coast of central Florida. This 1,250- ft2, 3-bedroom, 2-bath home achieved a Home Energy Rating System (HERS) score of 49. That is 70 points better than typical existing

  20. PIA - Savannah River Nuclear Solutions (SRNS) Human Resource Management

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    System (HRMS) | Department of Energy (SRNS) Human Resource Management System (HRMS) PIA - Savannah River Nuclear Solutions (SRNS) Human Resource Management System (HRMS) PIA - Savannah River Nuclear Solutions (SRNS) Human Resource Management System (HRMS) PIA - Savannah River Nuclear Solutions (SRNS) Human Resource Management System (HRMS) (3.39 MB) More Documents & Publications PIA - Savannah River Nuclear Solution (SRNS) Procurement Cycle System (PCS) PIA - Savannah River Site

  1. Human borna disease virus infection impacts host proteome and histone lysine acetylation in human oligodendroglia cells

    SciTech Connect (OSTI)

    Liu, Xia; Zhao, Libo; Yang, Yongtao; Bode, Liv; Huang, Hua; Liu, Chengyu; Huang, Rongzhong; Zhang, Liang; and others

    2014-09-15

    Background: Borna disease virus (BDV) replicates in the nucleus and establishes persistent infections in mammalian hosts. A human BDV strain was used to address the first time, how BDV infection impacts the proteome and histone lysine acetylation (Kac) of human oligodendroglial (OL) cells, thus allowing a better understanding of infection-driven pathophysiology in vitro. Methods: Proteome and histone lysine acetylation were profiled through stable isotope labeling for cell culture (SILAC)-based quantitative proteomics. The quantifiable proteome was annotated using bioinformatics. Histone acetylation changes were validated by biochemistry assays. Results: Post BDV infection, 4383 quantifiable differential proteins were identified and functionally annotated to metabolism pathways, immune response, DNA replication, DNA repair, and transcriptional regulation. Sixteen of the thirty identified Kac sites in core histones presented altered acetylation levels post infection. Conclusions: BDV infection using a human strain impacted the whole proteome and histone lysine acetylation in OL cells. - Highlights: • A human strain of BDV (BDV Hu-H1) was used to infect human oligodendroglial cells (OL cells). • This study is the first to reveal the host proteomic and histone Kac profiles in BDV-infected OL cells. • BDV infection affected the expression of many transcription factors and several HATs and HDACs.

  2. Human factors issues in qualitative and quantitative safety analyses

    SciTech Connect (OSTI)

    Hahn, H.A.

    1993-10-01

    Humans are a critical and integral part of any operational system, be it a nuclear reactor, a facility for assembly or disassembling hazardous components, or a transportation network. In our concern over the safety of these systems, we often focus our attention on the hardware engineering components of such systems. However, experience has repeatedly demonstrated that it is often the human component that is the primary determinant of overall system safety. Both the nuclear reactor accidents at Chernobyl and Three Mile Island and shipping disasters such as the Exxon Valdez and the Herald of Free Enterprise accidents are attributable to human error. Concern over human contributions to system safety prompts us to include reviews of human factors issues in our safety analyses. In the conduct of Probabilistic Risk Assessments (PRAs), human factors issues are addressed using a quantitative method called Human Reliability Analysis (HRA). HRAs typically begin with the identification of potential sources of human error in accident sequences of interest. Human error analysis often employs plant and/or procedures walk-downs in which the analyst considers the ``goodness`` of procedures, training, and human-machine interfaces concerning their potential contribution to human error. Interviews with expert task performers may also be conducted. In the application of HRA, once candidate sources of human error have been identified, error probabilities are developed.

  3. Assay for mutagenesis in heterozygous diploid human lymphoblasts

    DOE Patents [OSTI]

    Skopek, Thomas R.; Liber, Howard L.; Penman, Bruce W.; Thilly, William G.; Hoppe, IV, Henry

    1981-01-01

    An assay is disclosed for determining mutagenic damage caused by the administration of a known or suspected mutagen to diploid human lymphoblastoid cell lines. The gene locus employed for this assay is the gene for thymidine kinase, uridine kinase, or cytidine deaminase. Since human lymphoblastoid cells contain two genes for these enzymes, heterozygotes of human lymphoblastoid cells are used in this assay.

  4. Trichloroethylene toxicity in a human hepatoma cell line

    SciTech Connect (OSTI)

    Thevenin, E.; McMillian, J.

    1994-12-31

    The experiments conducted in this study were designed to determine the usefullness of hepatocyte cultures and a human hepatoma cell line as model systems for assessing human susceptibility to hepatocellular carcinoma due to exposure to trichloroethylene. The results from these studies will then be analyzed to determine if human cell lines can be used to conduct future experiments of this nature.

  5. PIA - Human Resources - Personal Information Change Request - Idaho

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    National Engineering Laboratory | Department of Energy - Personal Information Change Request - Idaho National Engineering Laboratory PIA - Human Resources - Personal Information Change Request - Idaho National Engineering Laboratory PIA - Human Resources - Personal Information Change Request - Idaho National Engineering Laboratory PIA - Human Resources - Personal Information Change Request - Idaho National Engineering Laboratory (278.62 KB) More Documents & Publications PIA - INL

  6. MODELING HUMAN RELIABILITY ANALYSIS USING MIDAS

    SciTech Connect (OSTI)

    Ronald L. Boring; Donald D. Dudenhoeffer; Bruce P. Hallbert; Brian F. Gore

    2006-05-01

    This paper summarizes an emerging collaboration between Idaho National Laboratory and NASA Ames Research Center regarding the utilization of high-fidelity MIDAS simulations for modeling control room crew performance at nuclear power plants. The key envisioned uses for MIDAS-based control room simulations are: (i) the estimation of human error with novel control room equipment and configurations, (ii) the investigative determination of risk significance in recreating past event scenarios involving control room operating crews, and (iii) the certification of novel staffing levels in control rooms. It is proposed that MIDAS serves as a key component for the effective modeling of risk in next generation control rooms.

  7. Human somatic, germinal and heritable mutagenicity

    SciTech Connect (OSTI)

    Mendelsohn, M.L.

    1987-05-01

    This report deals with the general process of variant formation rather than with the consequences of a specific variant being present. It focusses on mutational mechanisms, mutagens, and the method for detecting de novo mutants and estimating mutation rate. It is to human genetics much like disease causation and prevention medicine are to medicine as a whole. The word ''mutagenicity'' is used in the title and throughout the text to connote the causation of all classes of genetic damage. Mutagenicity and the corresponding words mutation, mutagen and mutagenesis can have multiple meaning, sometimes relating to gene mutation, sometimes to heritable mutation, and somtimes to all types of genetic damage. 38 refs., 1 tab.

  8. Adapting the U.S. Domestic Radiological Emergency Response Process to an Overseas Incident: FRMAC Without the F

    SciTech Connect (OSTI)

    Blumenthal, Daniel J.; Bowman, David R.; Remick, Alan

    2012-05-01

    The earthquake and resulting tsunami in Japan led to a radiological release from the Fukushima Daiichi Nuclear Power Plan, which in turn resulted in the rapid activation and deployment by the U.S. Department of Energy National Nuclear Security Administration (DOE/NNSA) emergency response teams. These teams and those from other federal agencies are typically coordinated through the Federal Radiological Monitoring and Assessment Center (FRMAC) when responding to radiological incidents in the U.S. FRMAC is the body through which the collection, analysis, and assessment of environmental radiological data are coordinated and products released to decision makers. This article discusses DOE/NNSAs role in the U.S. response to the Fukushima accident as it implemented its components of FRMAC in a foreign country, coordinated its assets, integrated with its federal partners, and collaborated with the Government of Japan. The technical details of the various data collections and analyses are covered in other articles of this issue.

  9. Understanding the origins of human cancer

    SciTech Connect (OSTI)

    Alexandrov, L. B.

    2015-12-04

    All cancers originate from a single cell that starts to behave abnormally, to divide uncontrollably, and, eventually, to invade adjacent tissues (1). The aberrant behavior of this single cell is due to somatic mutations—changes in the genomic DNA produced by the activity of different mutational processes (1). These various mutational processes include exposure to exogenous or endogenous mutagens, abnormal DNA editing, the incomplete fidelity of DNA polymerases, and failure of DNA repair mechanisms (2). Early studies that sequenced TP53, the most commonly mutated gene in human cancer, provided evidence that mutational processes leave distinct imprints of somatic mutations on the genome of a cancer cell (3). For example, C:G>A:T transversions predominate in smoking-associated lung cancer, whereas C:G>T:A transitions occurring mainly at dipyrimidines and CC:GG>TT:AA double-nucleotide substitutions are common in ultraviolet light–associated skin cancers. Moreover, these patterns of mutations matched the ones induced experimentally by tobacco mutagens and ultraviolet light, respectively, the major, known, exogenous carcinogenic influences in these cancer types, and demonstrated that examining patterns of mutations in cancer genomes can yield information about the mutational processes that cause human cancer (4).

  10. Structure of Human Ferritin L Chain

    SciTech Connect (OSTI)

    Wang,Z.; Li, C.; Ellenburg, M.; Soistman, E.; Ruble, J.; Wright, B.; Ho, J.; Carter, D.

    2006-01-01

    Ferritin is the major iron-storage protein present in all cells. It generally contains 24 subunits, with different ratios of heavy chain (H) to light chain (L), in the shape of a hollow sphere hosting up to 4500 ferric Fe atoms inside. H-rich ferritins catalyze the oxidation of iron(II), while L-rich ferritins promote the nucleation and storage of iron(III). Several X-ray structures have been determined, including those of L-chain ferritins from horse spleen (HoSF), recombinant L-chain ferritins from horse (HoLF), mouse (MoLF) and bullfrog (BfLF) as well as recombinant human H-chain ferritin (HuHF). Here, structures have been determined of two crystal forms of recombinant human L-chain ferritin (HuLF) obtained from native and perdeuterated proteins. The structures show a cluster of acidic residues at the ferrihydrite nucleation site and at the iron channel along the threefold axis. An ordered Cd{sup 2+} structure is observed within the iron channel, offering further insight into the route and mechanism of iron transport into the capsid. The loop between helices D and E, which is disordered in many other L-chain structures, is clearly visible in these two structures. The crystals generated from perdeuterated HuLF will be used for neutron diffraction studies.

  11. Nucleic acids encoding human trithorax protein

    DOE Patents [OSTI]

    Evans, Glen A.; Djabali, Malek; Selleri, Licia; Parry, Pauline

    2001-01-01

    In accordance with the present invention, there is provided an isolated peptide having the characteristics of human trithorax protein (as well as DNA encoding same, antisense DNA derived therefrom and antagonists therefor). The invention peptide is characterized by having a DNA binding domain comprising multiple zinc fingers and at least 40% amino acid identity with respect to the DNA binding domain of Drosophila trithorax protein and at least 70% conserved sequence with respect to the DNA binding domain of Drosophila trithorax protein, and wherein said peptide is encoded by a gene located at chromosome 11 of the human genome at q23. Also provided are methods for the treatment of subject(s) suffering from immunodeficiency, developmental abnormality, inherited disease, or cancer by administering to said subject a therapeutically effective amount of one of the above-described agents (i.e., peptide, antagonist therefor, DNA encoding said peptide or antisense DNA derived therefrom). Also provided is a method for the diagnosis, in a subject, of immunodeficiency, developmental abnormality, inherited disease, or cancer associated with disruption of chromosome 11 at q23.

  12. Understanding the origins of human cancer

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Alexandrov, L. B.

    2015-12-04

    All cancers originate from a single cell that starts to behave abnormally, to divide uncontrollably, and, eventually, to invade adjacent tissues (1). The aberrant behavior of this single cell is due to somatic mutations—changes in the genomic DNA produced by the activity of different mutational processes (1). These various mutational processes include exposure to exogenous or endogenous mutagens, abnormal DNA editing, the incomplete fidelity of DNA polymerases, and failure of DNA repair mechanisms (2). Early studies that sequenced TP53, the most commonly mutated gene in human cancer, provided evidence that mutational processes leave distinct imprints of somatic mutations on themore » genome of a cancer cell (3). For example, C:G>A:T transversions predominate in smoking-associated lung cancer, whereas C:G>T:A transitions occurring mainly at dipyrimidines and CC:GG>TT:AA double-nucleotide substitutions are common in ultraviolet light–associated skin cancers. Moreover, these patterns of mutations matched the ones induced experimentally by tobacco mutagens and ultraviolet light, respectively, the major, known, exogenous carcinogenic influences in these cancer types, and demonstrated that examining patterns of mutations in cancer genomes can yield information about the mutational processes that cause human cancer (4).« less

  13. Structure of the human type IV collagen COL4A6 gene, which is mutated in Alport syndrome-associated leiomyomatosis

    SciTech Connect (OSTI)

    Zhang, Xu |; Zhou, Jing; Reeders, S.T.

    1996-05-01

    Basement membrane (type IV) collagen, a subfamily of the collagen protein family, is encoded by six distinct genes in mammals. Three of those, COL4A3, COL4A4, and COL4A5, are linked with Alport syndrome (hereditary nephritis). Patients with leimoyomatosis associated with Alport syndrome have been shown to have deletions in the 5{prime} end of the COL4A6 gene, in addition to having deletions in COL4A6. The human COL4A6 gene is reported to be 425 kb as determined by mapping of overlapping YAC clones by probes for its 5{prime} and 3{prime} ends. In the present study we describe the complete exon/intron size pattern of the human COL4A6 gene. The 12 {lambda} phage clones characterized in the study spanned a total of 110 kb, including 85 kb of the actual gene and 25 kb of flanking sequences. The overlapping clones contained all 46 exons of the gene and all introns, except for intron 2. Since the total size of the exons and all introns except for intron 2 is about 85 kb, intron 2 must be about 340 kb. All exons of the gene were assigned to EcoRI restriction fragments to facilitate analysis of the gene in patients with leiomyomatosis associated with Alport syndrome. The exon size pattern of COL4A6 is highly homologous with that of the human and mouse COL4A2 genes, with 27 of the 46 exons of COL4A6 being identical in size between the genes. 42 refs., 2 figs., 3 tabs.

  14. Science-Based Simulation Model of Human Performance for Human Reliability Analysis

    SciTech Connect (OSTI)

    Dana L. Kelly; Ronald L. Boring; Ali Mosleh; Carol Smidts

    2011-10-01

    Human reliability analysis (HRA), a component of an integrated probabilistic risk assessment (PRA), is the means by which the human contribution to risk is assessed, both qualitatively and quantitatively. However, among the literally dozens of HRA methods that have been developed, most cannot fully model and quantify the types of errors that occurred at Three Mile Island. Furthermore, all of the methods lack a solid empirical basis, relying heavily on expert judgment or empirical results derived in non-reactor domains. Finally, all of the methods are essentially static, and are thus unable to capture the dynamics of an accident in progress. The objective of this work is to begin exploring a dynamic simulation approach to HRA, one whose models have a basis in psychological theories of human performance, and whose quantitative estimates have an empirical basis. This paper highlights a plan to formalize collaboration among the Idaho National Laboratory (INL), the University of Maryland, and The Ohio State University (OSU) to continue development of a simulation model initially formulated at the University of Maryland. Initial work will focus on enhancing the underlying human performance models with the most recent psychological research, and on planning follow-on studies to establish an empirical basis for the model, based on simulator experiments to be carried out at the INL and at the OSU.

  15. HUMAN RELIABILITY ANALYSIS FOR COMPUTERIZED PROCEDURES

    SciTech Connect (OSTI)

    Ronald L. Boring; David I. Gertman; Katya Le Blanc

    2011-09-01

    This paper provides a characterization of human reliability analysis (HRA) issues for computerized procedures in nuclear power plant control rooms. It is beyond the scope of this paper to propose a new HRA approach or to recommend specific methods or refinements to those methods. Rather, this paper provides a review of HRA as applied to traditional paper-based procedures, followed by a discussion of what specific factors should additionally be considered in HRAs for computerized procedures. Performance shaping factors and failure modes unique to computerized procedures are highlighted. Since there is no definitive guide to HRA for paper-based procedures, this paper also serves to clarify the existing guidance on paper-based procedures before delving into the unique aspects of computerized procedures.

  16. Mapping genes to human chromosome 19

    SciTech Connect (OSTI)

    Connolly, Sarah

    1996-05-01

    For this project, 22 Expressed Sequence Tags (ESTs) were fine mapped to regions of human chromosome 19. An EST is a short DNA sequence that occurs once in the genome and corresponds to a single expressed gene. {sup 32}P-radiolabeled probes were made by polymerase chain reaction for each EST and hybridized to filters containing a chromosome 19-specific cosmid library. The location of the ESTs on the chromosome was determined by the location of the ordered cosmid to which the EST hybridized. Of the 22 ESTs that were sublocalized, 6 correspond to known genes, and 16 correspond to anonymous genes. These localized ESTs may serve as potential candidates for disease genes, as well as markers for future physical mapping.

  17. Insights from Human/Mouse genome comparisons

    SciTech Connect (OSTI)

    Pennacchio, Len A.

    2003-03-30

    Large-scale public genomic sequencing efforts have provided a wealth of vertebrate sequence data poised to provide insights into mammalian biology. These include deep genomic sequence coverage of human, mouse, rat, zebrafish, and two pufferfish (Fugu rubripes and Tetraodon nigroviridis) (Aparicio et al. 2002; Lander et al. 2001; Venter et al. 2001; Waterston et al. 2002). In addition, a high-priority has been placed on determining the genomic sequence of chimpanzee, dog, cow, frog, and chicken (Boguski 2002). While only recently available, whole genome sequence data have provided the unique opportunity to globally compare complete genome contents. Furthermore, the shared evolutionary ancestry of vertebrate species has allowed the development of comparative genomic approaches to identify ancient conserved sequences with functionality. Accordingly, this review focuses on the initial comparison of available mammalian genomes and describes various insights derived from such analysis.

  18. Modeling aspects of human memory for scientific study.

    SciTech Connect (OSTI)

    Caudell, Thomas P.; Watson, Patrick; McDaniel, Mark A.; Eichenbaum, Howard B.; Cohen, Neal J.; Vineyard, Craig Michael; Taylor, Shawn Ellis; Bernard, Michael Lewis; Morrow, James Dan; Verzi, Stephen J.

    2009-10-01

    Working with leading experts in the field of cognitive neuroscience and computational intelligence, SNL has developed a computational architecture that represents neurocognitive mechanisms associated with how humans remember experiences in their past. The architecture represents how knowledge is organized and updated through information from individual experiences (episodes) via the cortical-hippocampal declarative memory system. We compared the simulated behavioral characteristics with those of humans measured under well established experimental standards, controlling for unmodeled aspects of human processing, such as perception. We used this knowledge to create robust simulations of & human memory behaviors that should help move the scientific community closer to understanding how humans remember information. These behaviors were experimentally validated against actual human subjects, which was published. An important outcome of the validation process will be the joining of specific experimental testing procedures from the field of neuroscience with computational representations from the field of cognitive modeling and simulation.

  19. Some aspects of statistical modeling of human-error probability

    SciTech Connect (OSTI)

    Prairie, R. R.

    1982-01-01

    Human reliability analyses (HRA) are often performed as part of risk assessment and reliability projects. Recent events in nuclear power have shown the potential importance of the human element. There are several on-going efforts in the US and elsewhere with the purpose of modeling human error such that the human contribution can be incorporated into an overall risk assessment associated with one or more aspects of nuclear power. An effort that is described here uses the HRA (event tree) to quantify and model the human contribution to risk. As an example, risk analyses are being prepared on several nuclear power plants as part of the Interim Reliability Assessment Program (IREP). In this process the risk analyst selects the elements of his fault tree that could be contributed to by human error. He then solicits the HF analyst to do a HRA on this element.

  20. Automated design synthesis of robotic/human workcells for improved manufacturing system design in hazardous environments

    SciTech Connect (OSTI)

    Williams, Joshua M.

    2012-06-12

    Manufacturing tasks that are deemed too hazardous for workers require the use of automation, robotics, and/or other remote handling tools. The associated hazards may be radiological or nonradiological, and based on the characteristics of the environment and processing, a design may necessitate robotic labor, human labor, or both. There are also other factors such as cost, ergonomics, maintenance, and efficiency that also effect task allocation and other design choices. Handling the tradeoffs of these factors can be complex, and lack of experience can be an issue when trying to determine if and what feasible automation/robotics options exist. To address this problem, we utilize common engineering design approaches adapted more for manufacturing system design in hazardous environments. We limit our scope to the conceptual and embodiment design stages, specifically a computational algorithm for concept generation and early design evaluation. In regard to concept generation, we first develop the functional model or function structure for the process, using the common 'verb-noun' format for describing function. A common language or functional basis for manufacturing was developed and utilized to formalize function descriptions and guide rules for function decomposition. Potential components for embodiment are also grouped in terms of this functional language and are stored in a database. The properties of each component are given as quantitative and qualitative criteria. Operators are also rated for task-relevant criteria which are used to address task compatibility. Through the gathering of process requirements/constraints, construction of the component database, and development of the manufacturing basis and rule set, design knowledge is stored and available for computer use. Thus, once the higher level process functions are defined, the computer can automate the synthesis of new design concepts through alternating steps of embodiment and function structure updates

  1. Beyond The Human Genome: What's Next? (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Rokhsar, Daniel

    2014-05-06

    UC Berkeley's Daniel Rokhsar and his colleagues were instrumental in contributing the sequences for three of the human body's chromosomes in the effort to decipher the blueprint of life- the completion of the DNA sequencing of the human genome. Now he is turning to the structure and function of genes in other organisms, some of them no less important to the planet's future than the human map. Hear the latest in this lecture from Lawrence Berkeley National Laboratory.

  2. Office of the Chief Human Capital Officer | Department of Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages

    Human Capital Officer Search Search form Search Office of the Chief Human Capital Officer Office of the Chief Human Capital Officer Services Services Home Benefits Benefits Home DOE Workers' Compensation Program Insurance Military/Reservist Retirement Telework Thrift Savings Plan (TSP) Wellness Programs Executive Resources Learning and Workforce Development New Employee Orientation Policy and Guidance Policy and Guidance Home Compensation Employment/Staffing Employment/Staffing Home Recruitment

  3. Contacts for the Assistant General Counsel for Contractor Human Resources |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Contractor Human Resources Contacts for the Assistant General Counsel for Contractor Human Resources Jean S. Stucky, Assistant General Counsel for Contractor Human Resources 202-586-7532 jean.stucky@hq.doe.gov Eva M. Auman, Attorney-Adviser 202-287-5630 Grant Programs Legacy/Closure Sites Hanford Moab National Energy Testing Laboratory National Renewable Energy Laboratory Pacific Northwest National Laboratory Waste Isolation Pilot Project (Carlsbad Field Office) Thomas

  4. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Irradiation Effects on Human Cortical Bone Fracture Behavior Print Wednesday, 28 July 2010 00:00 Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or

  5. Integrated Human Futures Modeling in Egypt

    SciTech Connect (OSTI)

    Passell, Howard D.; Aamir, Munaf Syed; Bernard, Michael Lewis; Beyeler, Walter E.; Fellner, Karen Marie; Hayden, Nancy Kay; Jeffers, Robert Fredric; Keller, Elizabeth James Kistin; Malczynski, Leonard A.; Mitchell, Michael David; Silver, Emily; Tidwell, Vincent C.; Villa, Daniel; Vugrin, Eric D.; Engelke, Peter; Burrow, Mat; Keith, Bruce

    2016-01-01

    The Integrated Human Futures Project provides a set of analytical and quantitative modeling and simulation tools that help explore the links among human social, economic, and ecological conditions, human resilience, conflict, and peace, and allows users to simulate tradeoffs and consequences associated with different future development and mitigation scenarios. In the current study, we integrate five distinct modeling platforms to simulate the potential risk of social unrest in Egypt resulting from the Grand Ethiopian Renaissance Dam (GERD) on the Blue Nile in Ethiopia. The five platforms simulate hydrology, agriculture, economy, human ecology, and human psychology/behavior, and show how impacts derived from development initiatives in one sector (e.g., hydrology) might ripple through to affect other sectors and how development and security concerns may be triggered across the region. This approach evaluates potential consequences, intended and unintended, associated with strategic policy actions that span the development-security nexus at the national, regional, and international levels. Model results are not intended to provide explicit predictions, but rather to provide system-level insight for policy makers into the dynamics among these interacting sectors, and to demonstrate an approach to evaluating short- and long-term policy trade-offs across different policy domains and stakeholders. The GERD project is critical to government-planned development efforts in Ethiopia but is expected to reduce downstream freshwater availability in the Nile Basin, fueling fears of negative social and economic impacts that could threaten stability and security in Egypt. We tested these hypotheses and came to the following preliminary conclusions. First, the GERD will have an important short-term impact on water availability, food production, and hydropower production in Egypt, depending on the short- term reservoir fill rate. Second, the GERD will have a very small impact on

  6. Human Papillomavirus (HPV) Infection in Squamous Cell Carcinomas...

    Office of Scientific and Technical Information (OSTI)

    Human Papillomavirus (HPV) Infection in Squamous Cell Carcinomas Arising From the ... Resource Relation: Journal Name: International Journal of Radiation Oncology, Biology and ...

  7. Genome Wide Evaluation of Normal Human Tissue in Response to...

    Office of Scientific and Technical Information (OSTI)

    Wide Evaluation of Normal Human Tissue in Response to Controlled, In vivo Low-Dose Low LET Ionizing Radiation Exposure: Pathways and Mechanisms Final Report, September 2013 Rocke,...

  8. Sandia Energy - Results from the Human Resilience Index and Modeling...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Results from the Human Resilience Index and Modeling project were reported recently in the National Intelligence Council's Global Trends 2030 Report Home Infrastructure Security...

  9. Building America Case Study: Columbia County Habitat for Humanity...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Columbia County Habitat for Humanity Passive Townhomes Hudson, New York PROJECT INFORMATION Project Name: Columbia Passive Townhomes II Location: Hudson, NY Partners: Columbia ...

  10. Creating a Tiny Human Body on a Chip

    ScienceCinema (OSTI)

    Hunsberger, Maren; Soscia, Dave; Moya, Monica

    2016-03-16

    LLNL science communicator Maren Hunsberger takes us "Inside the Lab" to learn about the iChip (In-vitro Chip-based Human Investigational Platform) project at Lawrence Livermore National Laboratory. "One application of the iChip system would be to develop new pharmaceutical drugs," explains Dave Soscia, LLNL postdoc. "When you test in a mouse for example, it's not as close to the human system as you can get. If we can take human cells and put them on devices and actually mimic the structure and function of the organ systems in the human, we can actually replace animal testing and even make a better system for testing pharmaceutical drugs."

  11. Handbook of human-reliability analysis with emphasis on nuclear...

    Office of Scientific and Technical Information (OSTI)

    emphasis on nuclear power plant applications. Final report Citation Details In-Document Search Title: Handbook of human-reliability analysis with emphasis on nuclear power plant ...

  12. Acid soluble platelet aggregating material isolated from human umbilical cord

    DOE Patents [OSTI]

    Schneider, Morris D.

    1983-01-01

    Acid soluble, pepsin sensitive platelet aggregating material isolated from human umbilical cord tissue by extraction with dilute aqueous acid, method of isolation and use to control bleeding.

  13. Columbia County Habitat for Humanity Passive Townhomes (Technical...

    Office of Scientific and Technical Information (OSTI)

    (specifically with respect to exterior wall, space-conditioning, and ventilation strategies) within the labor and budget context inherent in a Habitat for Humanity project. ...

  14. Metabolome of human gut microbiome is predictive of host dysbiosis

    SciTech Connect (OSTI)

    Larsen, Peter E.; Dai, Yang

    2015-09-14

    Background: Humans live in constant and vital symbiosis with a closely linked bacterial ecosystem called the microbiome, which influences many aspects of human health. When this microbial ecosystem becomes disrupted, the health of the human host can suffer; a condition called dysbiosis. The community compositions of human microbiomes also vary dramatically from individual to individual, and over time, making it difficult to uncover the underlying mechanisms linking the microbiome to human health. We propose that a microbiome’s interaction with its human host is not necessarily dependent upon the presence or absence of particular bacterial species, but instead is dependent on its community metabolome; an emergent property of the microbiome. Results: Using data from a previously published, longitudinal study of microbiome populations of the human gut, we extrapolated information about microbiome community enzyme profiles and metabolome models. Using machine learning techniques, we demonstrated that the aggregate predicted community enzyme function profiles and modeled metabolomes of a microbiome are more predictive of dysbiosis than either observed microbiome community composition or predicted enzyme function profiles. Conclusions: Specific enzyme functions and metabolites predictive of dysbiosis provide insights into the molecular mechanisms of microbiome–host interactions. The ability to use machine learning to predict dysbiosis from microbiome community interaction data provides a potentially powerful tool for understanding the links between the human microbiome and human health, pointing to potential microbiome-based diagnostics and therapeutic interventions.

  15. Massively Parallel Models of the Human Circulatory System (Conference...

    Office of Scientific and Technical Information (OSTI)

    Massively Parallel Models of the Human Circulatory System Citation Details In-Document ... Sponsoring Org: USDOE Country of Publication: United States Language: English Subject: 59 ...

  16. DOE human genome program contractor-grantee workshop VI

    SciTech Connect (OSTI)

    1997-10-01

    Research is presented from the workshop on the Human Genome Project. Topics include sequencing, genetic mapping, informatics, ethical and legal issues, and infrastructure.

  17. OSTIblog Articles in the Human Genome Project Topic | OSTI, US...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Related Topics: Charles DeLisi, DNA, DOE Research & Development (R&D) Accomplishments, genomics, Human Genome Project, Santa Fe Workshop, sequencing Read more... DOE Research ...

  18. Metabolome of human gut microbiome is predictive of host dysbiosis

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Larsen, Peter E.; Dai, Yang

    2015-09-14

    Background: Humans live in constant and vital symbiosis with a closely linked bacterial ecosystem called the microbiome, which influences many aspects of human health. When this microbial ecosystem becomes disrupted, the health of the human host can suffer; a condition called dysbiosis. The community compositions of human microbiomes also vary dramatically from individual to individual, and over time, making it difficult to uncover the underlying mechanisms linking the microbiome to human health. We propose that a microbiome’s interaction with its human host is not necessarily dependent upon the presence or absence of particular bacterial species, but instead is dependent onmore » its community metabolome; an emergent property of the microbiome. Results: Using data from a previously published, longitudinal study of microbiome populations of the human gut, we extrapolated information about microbiome community enzyme profiles and metabolome models. Using machine learning techniques, we demonstrated that the aggregate predicted community enzyme function profiles and modeled metabolomes of a microbiome are more predictive of dysbiosis than either observed microbiome community composition or predicted enzyme function profiles. Conclusions: Specific enzyme functions and metabolites predictive of dysbiosis provide insights into the molecular mechanisms of microbiome–host interactions. The ability to use machine learning to predict dysbiosis from microbiome community interaction data provides a potentially powerful tool for understanding the links between the human microbiome and human health, pointing to potential microbiome-based diagnostics and therapeutic interventions.« less

  19. Identifying Requirements for Effective Human-Automation Teamwork

    SciTech Connect (OSTI)

    Jeffrey C. Joe; John O'Hara; Heather D. Medema; Johanna H. Oxstrand

    2014-06-01

    Previous studies have shown that poorly designed human-automation collaboration, such as poorly designed communication protocols, often leads to problems for the human operators, such as: lack of vigilance, complacency, and loss of skills. These problems often lead to suboptimal system performance. To address this situation, a considerable amount of research has been conducted to improve human-automation collaboration and to make automation function better as a “team player.” Much of this research is based on an understanding of what it means to be a good team player from the perspective of a human team. However, the research is often based on a simplified view of human teams and teamwork. In this study, we sought to better understand the capabilities and limitations of automation from the standpoint of human teams. We first examined human teams to identify the principles for effective teamwork. We next reviewed the research on integrating automation agents and human agents into mixed agent teams to identify the limitations of automation agents to conform to teamwork principles. This research resulted in insights that can lead to more effective human-automation collaboration by enabling a more realistic set of requirements to be developed based on the strengths and limitations of all agents.

  20. Structure and mechanism of human DNA polymerase [eta] (Journal...

    Office of Scientific and Technical Information (OSTI)

    DNA polymerase eta Citation Details In-Document ... Here we report high-resolution crystal structures of human ... OSTI Identifier: 1002510 Resource Type: Journal Article ...

  1. Director, Human Resources Shared Service Center (Management and Performance)

    Broader source: Energy.gov [DOE]

    The Office of the Chief Human Capital Officer (OCHCO) is a progressive and contemporary organization that partners with the DOE leadership to maximize the talent, diversity, commitment and...

  2. Building America Case Study: Habitat for Humanity, The Woods...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Type: Single-family, affordable Partners: Tacoma Public Utilities, mytpu.org Habitat for Humanity of Tacoma Pierce County, WA, tpc-habitat.org Building America Partnership for ...

  3. Fluorescent tracking of nickel ions in human cultured cells ...

    Office of Scientific and Technical Information (OSTI)

    Fluorescent tracking of nickel ions in human cultured cells Citation Details In-Document ... B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International ...

  4. Groundwater Resources Assessment under the Pressures of Humanity...

    Open Energy Info (EERE)

    Resources Assessment under the Pressures of Humanity and Climate Change (GRAPHIC) Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Groundwater Resources Assessment under...

  5. Handbook of human-reliability analysis with emphasis on nuclear...

    Office of Scientific and Technical Information (OSTI)

    nuclear power plant applications. Final report Citation Details In-Document Search Title: Handbook of human-reliability analysis with emphasis on nuclear power plant applications. ...

  6. Before House Subcommittee on Africa, Global Health, Global Human...

    Broader source: Energy.gov (indexed) [DOE]

    Testimony of Jonathan Elkind, Acting Assistant Secretary, Office of International Affairs Before House Subcommittee on Africa, Global Health, Global Human Rights, and International ...

  7. First Steps Towards Tribal Weatherization: Human Capacity Development

    Broader source: Energy.gov (indexed) [DOE]

    Towards Tribal Weatherization: Human Capacity Development October 2011 October 2011 Cook Inlet Tribal Council's Weatherization Apprenticeship October 2011 March 2010 - March 2012 ...

  8. First Steps Towards Tribal Weatherization: Human Capacity Development

    Broader source: Energy.gov (indexed) [DOE]

    Steps Towards tribal weatherization: human capacity development October 2010 - Cook Inlet Tribal Council Weatherization Apprenticeship March 2010 February 2012 Cook Inlet Tribal ...

  9. Human Resources at Oak Ridge National Laboratory | Critical Materials...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Oak Ridge National Laboratory Contact Information The main contact for human resources for CMI at Oak Ridge National Laboratory: David Lett Phone: 865-576-5675 Email: ...

  10. POLICY BULLETIN: POL-5- Declassification Instruction "25X1-human"

    Broader source: Energy.gov [DOE]

    Provides instructions on the appropriate action to take when classification guide topics or source documents cite "25X1-human" declassification instructions.

  11. Human Resources at Lawrence Livermore National Laboratory | Critical...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lawrence Livermore National Laboratory Careers at Lawrence Livermore National Laboratory Main contacts in Human Resources for recruitment and hiring: Jennifer Brizel Recruitment & ...

  12. Human Resources at Critical Materials Institute | Critical Materials...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources at Critical Materials Institute Each partner within the Critical Materials Institute manages its own hiring. Use these links to find key contacts for CMI partners ...

  13. Human Resources at Idaho National Laboratory | Critical Materials...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Idaho National Laboratory Link to Office of Human Resources INL Staffing (208) 526-5888 Link to infographic on reasons to work at INL

  14. Fifty Years of THERP and Human Reliability Analysis

    SciTech Connect (OSTI)

    Ronald L. Boring

    2012-06-01

    In 1962 at a Human Factors Society symposium, Alan Swain presented a paper introducing a Technique for Human Error Rate Prediction (THERP). This was followed in 1963 by a Sandia Laboratories monograph outlining basic human error quantification using THERP and, in 1964, by a special journal edition of Human Factors on quantification of human performance. Throughout the 1960s, Swain and his colleagues focused on collecting human performance data for the Sandia Human Error Rate Bank (SHERB), primarily in connection with supporting the reliability of nuclear weapons assembly in the US. In 1969, Swain met with Jens Rasmussen of Risø National Laboratory and discussed the applicability of THERP to nuclear power applications. By 1975, in WASH-1400, Swain had articulated the use of THERP for nuclear power applications, and the approach was finalized in the watershed publication of the NUREG/CR-1278 in 1983. THERP is now 50 years old, and remains the most well known and most widely used HRA method. In this paper, the author discusses the history of THERP, based on published reports and personal communication and interviews with Swain. The author also outlines the significance of THERP. The foundations of human reliability analysis are found in THERP: human failure events, task analysis, performance shaping factors, human error probabilities, dependence, event trees, recovery, and pre- and post-initiating events were all introduced in THERP. While THERP is not without its detractors, and it is showing signs of its age in the face of newer technological applications, the longevity of THERP is a testament of its tremendous significance. THERP started the field of human reliability analysis. This paper concludes with a discussion of THERP in the context of newer methods, which can be seen as extensions of or departures from Swain’s pioneering work.

  15. Human Factors Aspects of Operating Small Reactors

    SciTech Connect (OSTI)

    OHara, J.M.; Higgins, J.; Deem, R.; Xing, J.; DAgostino, A.

    2010-11-07

    The nuclear-power community has reached the stage of proposing advanced reactor designs to support power generation for decades to come. They are considering small modular reactors (SMRs) as one approach to meet these energy needs. While the power output of individual reactor modules is relatively small, they can be grouped to produce reactor sites with different outputs. Also, they can be designed to generate hydrogen, or to process heat. Many characteristics of SMRs are quite different from those of current plants, and so may require a concept of operations (ConOps) that also is different. The U.S. Nuclear Regulatory Commission (NRC) has begun examining the human factors engineering- (HFE) and ConOps- aspects of SMRs; if needed, they will formulate guidance to support SMR licensing reviews. We developed a ConOps model, consisting of the following dimensions: Plant mission; roles and responsibilities of all agents; staffing, qualifications, and training; management of normal operations; management of off-normal conditions and emergencies; and, management of maintenance and modifications. We are reviewing information on SMR design to obtain data about each of these dimensions, and have identified several preliminary issues. In addition, we are obtaining operations-related information from other types of multi-module systems, such as refineries, to identify lessons learned from their experience. Here, we describe the project's methodology and our preliminary findings.

  16. Before House Subcommittee on Africa, Global Health, Global Human Rights,

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and International Organizations, Committee on Foreign Affairs | Department of Energy House Subcommittee on Africa, Global Health, Global Human Rights, and International Organizations, Committee on Foreign Affairs Before House Subcommittee on Africa, Global Health, Global Human Rights, and International Organizations, Committee on Foreign Affairs Testimony of Jonathan Elkind, Acting Assistant Secretary, Office of International Affairs Before House Subcommittee on Africa, Global Health, Global

  17. YAC contigs mapping the human COL4A5 and COL4A6 genes and DXS118 within Xq21.3-q22

    SciTech Connect (OSTI)

    Srivastava, A.K.; Featherstone, T.; Wein, K.

    1995-04-10

    Sequence-tagged sites (STSs) were developed for three loci of uncertain X chromosomal localization (DXS122, DXS137, and DXS174) and were used to seed YAC contigs. Two contigs now total about 3.3 Mb formatted with 34 STSs. One contains DXS122 and DXS174 within 250 kb on single YACs; it is placed in Xq21.3-q22.1 by FISH analysis, which is consistent with somatic cell hybrid panel analyses and with the inclusion of a probe that detects polymorphism at the DXS118 locus already assigned to that general region. The other contig, which contains DXS137, is in Xq22.2 by FISH, consistent with cell hybrid analyses and with the finding that it covers the human COL4A5 and COL4A6 genes known to be in that vicinity. In addition to extending the cloned coverage of this portion of the X chromosome, these materials should aid, for example, in the further analysis of Alport syndrome. 50 refs., 2 figs., 2 tabs.

  18. Summary of human responses to ventilation

    SciTech Connect (OSTI)

    Seppanen, Olli A.; Fisk, William J.

    2004-06-01

    The effects of ventilation on indoor air quality and health is a complex issue. It is known that ventilation is necessary to remove indoor generated pollutants from indoor air or dilute their concentration to acceptable levels. But, as the limit values of all pollutants are not known, the exact determination of required ventilation rates based on pollutant concentrations and associated risks is seldom possible. The selection of ventilation rates has to be based also on epidemiological research (e.g. Seppanen et al., 1999), laboratory and field experiments (e.g. CEN 1996, Wargocki et al., 2002a) and experience (e.g. ECA 2003). Ventilation may also have harmful effects on indoor air quality and climate if not properly designed, installed, maintained and operated as summarized by Seppdnen (2003). Ventilation may bring indoors harmful substances that deteriorate the indoor environment. Ventilation also affects air and moisture flow through the building envelope and may lead to moisture problems that deteriorate the structures of the building. Ventilation changes the pressure differences over the structures of building and may cause or prevent the infiltration of pollutants from structures or adjacent spaces. Ventilation is also in many cases used to control the thermal environment or humidity in buildings. Ventilation can be implemented with various methods which may also affect health (e.g. Seppdnen and Fisk, 2002, Wargocki et al., 2002a). In non residential buildings and hot climates, ventilation is often integrated with air-conditioning which makes the operation of ventilation system more complex. As ventilation is used for many purposes its health effects are also various and complex. This paper summarizes the current knowledge on positive and negative effects of ventilation on health and other human responses. The focus of the paper is on office-type working environment and residential buildings. In the industrial premises the problems of air quality are usually

  19. Alternative splicing variants of human Fbx4 disturb cyclin D1 proteolysis in human cancer

    SciTech Connect (OSTI)

    Chu, Xiufeng; Zhang, Ting; Wang, Jie; Li, Meng; Zhang, Xiaolei; Tu, Jing; Sun, Shiqin; Chen, Xiangmei; Lu, Fengmin

    2014-04-25

    Highlights: The expression of Fbx4 was significantly lower in HCC tissues. Novel splicing variants of Fbx4 were identified. These novel variants are much more abundant in human cancer tissues and cells. The novel Fbx4 isoforms could promote cell proliferation and migration in vitro. These isoforms showed less capability for cyclin D1 binding and degradation. - Abstract: Fbx4 is a specific substrate recognition component of SCF ubiquitin ligases that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. Two isoforms of human Fbx4 protein, the full length Fbx4? and the C-terminal truncated Fbx4? have been identified, but their functions remain elusive. In this study, we demonstrated that the mRNA level of Fbx4 was significantly lower in hepatocellular carcinoma tissues than that in the corresponding non-tumor tissues. More importantly, we identified three novel splicing variants of Fbx4: Fbx4? (missing 168245nt of exon1), Fbx4? (missing exon6) and a N-terminal reading frame shift variant (missing exon2). Using cloning sequencing and RT-PCR, we demonstrated these novel splice variants are much more abundant in human cancer tissues and cell lines than that in normal tissues. When expressed in Sk-Hep1 and NIH3T3 cell lines, Fbx4?, Fbx4? and Fbx4? could promote cell proliferation and migration in vitro. Concordantly, these isoforms could disrupt cyclin D1 degradation and therefore increase cyclin D1 expression. Moreover, unlike the full-length isoform Fbx4? that mainly exists in cytoplasm, Fbx4?, Fbx4?, and Fbx4? locate in both cytoplasm and nucleus. Since cyclin D1 degradation takes place in cytoplasm, the nuclear distribution of these Fbx4 isoforms may not be involved in the down-regulation of cytoplasmic cyclin D1. These results define the impact of alternative splicing on Fbx4 function, and suggest that the attenuated cyclin D1 degradation by these novel Fbx4 isoforms provides a new insight for aberrant cyclin D1 expression in

  20. Finishing The Euchromatic Sequence Of The Human Genome

    SciTech Connect (OSTI)

    Rubin, Edward M.; Lucas, Susan; Richardson, Paul; Rokhsar, Daniel; Pennacchio, Len

    2004-09-07

    The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process.The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers {approx}99% of the euchromatic genome and is accurate to an error rate of {approx}1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number,birth and death. Notably, the human genome seems to encode only20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead.

  1. The Development of A Human Systems Simulation Laboratory: Strategic Direction

    SciTech Connect (OSTI)

    Jacques Hugo; Katya le Blanc; David Gertman

    2012-07-01

    The Human System Simulation Laboratory (HSSL) at the Idaho National Laboratory is one of few facilities of its kind that allows human factors researchers to evaluate various aspects of human performance and human system interaction for proposed reactor designs and upgrades. A basic system architecture, physical configuration and simulation capability were established to enable human factors researchers to support multiple, simultaneous simulations and also different power plant technologies. Although still evolving in terms of its technical and functional architecture, the HSSL is already proving its worth in supporting current and future nuclear industry needs for light water reactor sustainability and small modular reactors. The evolution of the HSSL is focused on continual physical and functional refinement to make it a fully equipped, reconfigurable facility where advanced research, testing and validation studies can be conducted on a wider range of reactor technologies. This requires the implementation of additional plant models to produce empirical research data on human performance with emerging human-system interaction technologies. Additional beneficiaries of this information include system designers and HRA practitioners. To ensure that results of control room crew studies will be generalizable to the existing and evolving fleet of US reactors, future expansion of the HSSL may also include other SMR plant models, plant-specific simulators and a generic plant model aligned to the current generation of pressurized water reactors (PWRs) and future advanced reactor designs. Collaboration with industry partners is also proving to be a vital component of the facility as this helps to establish a formal basis for current and future human performance experiments to support nuclear industry objectives. A long-range Program Plan has been developed for the HSSL to ensure that the facility will support not only the Department of Energys Light Water Reactor

  2. 99M-technetium labeled macroaggregated human serum albumin pharmaceutical

    DOE Patents [OSTI]

    Winchell, Harry S.; Barak, Morton; Van Fleet, III, Parmer

    1977-05-17

    A reagent comprising macroaggregated human serum albumin having dispersed therein particles of stannous tin and a method for instantly making a labeled pharmaceutical therefrom, are disclosed. The labeled pharmaceutical is utilized in organ imaging.

  3. Habitat for Humanity of Metro Denver Zero Energy Demonstration Home

    SciTech Connect (OSTI)

    Not Available

    2008-04-01

    This brochure describes the 2005 demonstration home designed by NREL and the Habitat for Humanity of Metro Denver. The completed home produced 24% more energy than it consumed over 12 months.

  4. Metabolome of human gut microbiome is predictive of host dysbiosis

    Office of Scientific and Technical Information (OSTI)

    ... Nature. 2014;509(7500):357-60. 48. Lax S, Smith DP, Hampton-Marcell J, Owens SM, Handley KM, Scott NM, et al. Longitudinal analysis of microbial interaction between humans and the ...

  5. Human choice and climate change. Volume 1: The societal framework

    SciTech Connect (OSTI)

    Rayner, S.; Malone, E.L.

    1997-12-31

    Foreward: Preface; Introduction; Science and decisionmaking; Population and climate change; Human needs and wants; Cultural discourses; Institutional frameworks for political action; and Sponsoring organizations, International Advisory Board, and project participants.

  6. The sequence and analysis of duplication rich human chromosome 16

    SciTech Connect (OSTI)

    Martin, Joel; Han, Cliff; Gordon, Laurie A.; Terry, Astrid; Prabhakar, Shyam; She, Xinwei; Xie, Gary; Hellsten, Uffe; Man Chan, Yee; Altherr, Michael; Couronne, Olivier; Aerts, Andrea; Bajorek, Eva; Black, Stacey; Blumer, Heather; Branscomb, Elbert; Brown, Nancy C.; Bruno, William J.; Buckingham, Judith M.; Callen, David F.; Campbell, Connie S.; Campbell, Mary L.; Campbell, Evelyn W.; Caoile, Chenier; Challacombe, Jean F.; Chasteen, Leslie A.; Chertkov, Olga; Chi, Han C.; Christensen, Mari; Clark, Lynn M.; Cohn, Judith D.; Denys, Mirian; Detter, John C.; Dickson, Mark; Dimitrijevic-Bussod, Mira; Escobar, Julio; Fawcett, Joseph J.; Flowers, Dave; Fotopulos, Dea; Glavina, Tijana; Gomez, Maria; Gonzales, Eidelyn; Goodstein, David; Goodwin, Lynne A.; Grady, Deborah L.; Grigoriev, Igor; Groza, Matthew; Hammon, Nancy; Hawkins, Trevor; Haydu, Lauren; Hildebrand, Carl E.; Huang, Wayne; Israni, Sanjay; Jett, Jamie; Jewett, Phillip E.; Kadner, Kristen; Kimball, Heather; Kobayashi, Arthur; Krawczyk, Marie-Claude; Leyba, Tina; Longmire, Jonathan L.; Lopez, Frederick; Lou, Yunian; Lowry, Steve; Ludeman, Thom; Mark, Graham A.; Mcmurray, Kimberly L.; Meincke, Linda J.; Morgan, Jenna; Moyzis, Robert K.; Mundt, Mark O.; Munk, A. Christine; Nandkeshwar, Richard D.; Pitluck, Sam; Pollard, Martin; Predki, Paul; Parson-Quintana, Beverly; Ramirez, Lucia; Rash, Sam; Retterer, James; Ricke, Darryl O.; Robinson, Donna L.; Rodriguez, Alex; Salamov, Asaf; Saunders, Elizabeth H.; Scott, Duncan; Shough, Timothy; Stallings, Raymond L.; Stalvey, Malinda; Sutherland, Robert D.; Tapia, Roxanne; Tesmer, Judith G.; Thayer, Nina; Thompson, Linda S.; Tice, Hope; Torney, David C.; Tran-Gyamfi, Mary; Tsai, Ming; Ulanovsky, Levy E.; Ustaszewska, Anna; Vo, Nu; White, P. Scott; Williams, Albert L.; Wills, Patricia L.; Wu, Jung-Rung; Wu, Kevin; Yang, Joan; DeJong, Pieter; Bruce, David; Doggett, Norman; Deaven, Larry; Schmutz, Jeremy; Grimwood, Jane; Richardson, Paul; et al.

    2004-08-01

    We report here the 78,884,754 base pairs of finished human chromosome 16 sequence, representing over 99.9 percent of its euchromatin. Manual annotation revealed 880 protein coding genes confirmed by 1,637 aligned transcripts, 19 tRNA genes, 341 pseudogenes and 3 RNA pseudogenes. These genes include metallothionein, cadherin and iroquois gene families, as well as the disease genes for polycystic kidney disease and acute myelomonocytic leukemia. Several large-scale structural polymorphisms spanning hundreds of kilobasepairs were identified and result in gene content differences across humans. One of the unique features of chromosome 16 is its high level of segmental duplication, ranked among the highest of the human autosomes. While the segmental duplications are enriched in the relatively gene poor pericentromere of the p-arm, some are involved in recent gene duplication and conversion events which are likely to have had an impact on the evolution of primates and human disease susceptibility.

  7. A human reliability analysis of a nuclear explosives dismantlement

    SciTech Connect (OSTI)

    Bott, T.F.

    1995-07-01

    This paper describes the methodology used in a human reliability analysis (HRA) conducted during a quantitative hazard assessment of a nuclear weapon disassembly process performed at the Pantex plant. The probability of human errors during the disassembly process is an extremely important aspect of estimating accident-sequence frequency for nuclear weapons processing. The methods include the systematic identification of potential human-initiated or enabled accident sequences using an accident-sequence fault tree, the extensive use of walkthroughs and videotaping of the disassembly process, and hands-on testing of postulated human errors. THERP modeling of rule-based behavior and operational data analysis of errors in skill-based behavior are described. A simple method for evaluating the approximate likelihood of nonmalevolent violations of procedures was developed and used to examine the process. The HRA occurred concurrently with process design, so considerable interaction between the analysts and designers occurred and resulted in design changes that are discussed in the paper.

  8. Apparatus and methods for a human de-amplifier system

    DOE Patents [OSTI]

    Kress, Reid L.; Jansen, John F.

    2000-01-01

    A human de-amplifier system for interfacing a human operator and a physical object through a physical plant, wherein the physical object has dimensions in the range of 1 micrometer to 1 mm. The human de-amplifier system uses an inner-feedback loop to increases the equivalent damping of the operating system to stabilize the system when it contacts with the environment and reduces the impact of the environment variation by utilizing a high feedback gain, determined by a root locus sketch. Because the stability of the human de-amplifier system of the present invention is greatly enhanced over that of the prior art, the de-amplifier system is able to manipulate the physical object has dimensions in the range of 1 micrometer to 1 mm with high stability and accuracy. The system also has a monitoring device to monitor the motion of the physical object under manipulation.

  9. Quantification of the effects of dependence on human error probabiliti...

    Office of Scientific and Technical Information (OSTI)

    In estimating the probabilities of human error in the performance of a series of tasks in a nuclear power plant, the situation-specific characteristics of the series must be ...

  10. Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins

    DOE Patents [OSTI]

    Korber, Bette T.; Perkins, Simon; Bhattacharya, Tanmoy; Fischer, William M.; Theiler, James; Letvin, Norman; Haynes, Barton F.; Hahn, Beatrice H.; Yusim, Karina; Kuiken, Carla

    2012-02-21

    The present invention relates to mosaic clade M HIV-1 Nef polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.

  11. ORS 97 - Rights and Duties Relating to Cemeteries, Human Bodies...

    Open Energy Info (EERE)

    97 - Rights and Duties Relating to Cemeteries, Human Bodies and Anatomical Gifts Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute:...

  12. NMHPD Application for Permit to Excavate Human Burials | Open...

    Open Energy Info (EERE)

    NMHPD Application for Permit to Excavate Human Burials Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- OtherOther: NMHPD Application for Permit...

  13. Confederated Tribes of Warm Springs - Human Capacity Building

    Broader source: Energy.gov (indexed) [DOE]

    Grant DE-PS36-06G096038 Human Capacity Building for Renewable Energy Development. Warm Spring Power and Water Enterprise Mark K. Johnson Jr. Prepared by: Warm Springs Power & Water ...

  14. Chief Human Capital Officer Memo on Improving DOE Recruitment...

    Broader source: Energy.gov (indexed) [DOE]

    Improving DOE Recruitment and Hiring Processes (540.02 KB) Responsible Contacts Kenneth Venuto Director, Office of Human Capital Management E-mail kenneth.venuto@hq.doe.gov More ...

  15. Human Capital: The Role of Ombudsmen in Dispute Resolution |...

    Broader source: Energy.gov (indexed) [DOE]

    Human Capital: The Role of Ombudsmen in Dispute Resolution (339.67 KB) More Documents & Publications The Role of Ombudsmen in Dispute Resolution TT Coordinator Ltr dated May 13 ...

  16. Predicting Human Blood Viscosity in Silico | Argonne Leadership...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Predicting Human Blood Viscosity in Silico Authors: Fedosov., D. A., Pan, W., Caswell, B., Gompper, G., Karniadakis, G.E. The viscosity of blood has long been used as an indicator ...

  17. The Sequence and Analysis of Duplication Rich Human Chromosome 16

    DOE R&D Accomplishments [OSTI]

    Martin, Joel; Han, Cliff; Gordon, Laurie A.; Terry, Astrid; Prabhakar, Shyam; She, Xinwei; Xie, Gary; Hellsten, Uffe; Man Chan, Yee; Altherr, Michael; Couronne, Olivier; Aerts, Andrea; Bajorek, Eva; Black, Stacey; Blumer, Heather; Branscomb, Elbert; Brown, Nancy C.; Bruno, William J.; Buckingham, Judith M.; Callen, David F.; Campbell, Connie S.; Campbell, Mary L.; Campbell, Evelyn W.; Caoile, Chenier; Challacombe, Jean F.; Chasteen, Leslie A.; Chertkov, Olga; Chi, Han C.; Christensen, Mari; Clark, Lynn M.; Cohn, Judith D.; Denys, Mirian; Detter, John C.; Dickson, Mark; Dimitrijevic-Bussod, Mira; Escobar, Julio; Fawcett, Joseph J.; Flowers, Dave; Fotopulos, Dea; Glavina, Tijana; Gomez, Maria; Gonzales, Eidelyn; Goodstein, David; Goodwin, Lynne A.; Grady, Deborah L.; Grigoriev, Igor; Groza, Matthew; Hammon, Nancy; Hawkins, Trevor; Haydu, Lauren; Hildebrand, Carl E.; Huang, Wayne; Israni, Sanjay; Jett, Jamie; Jewett, Phillip E.; Kadner, Kristen; Kimball, Heather; Kobayashi, Arthur; Krawczyk, Marie-Claude; Leyba, Tina; Longmire, Jonathan L.; Lopez, Frederick; Lou, Yunian; Lowry, Steve; Ludeman, Thom; Mark, Graham A.; Mcmurray, Kimberly L.; Meincke, Linda J.; Morgan, Jenna; Moyzis, Robert K.; Mundt, Mark O.; Munk, A. Christine; Nandkeshwar, Richard D.; Pitluck, Sam; Pollard, Martin; Predki, Paul; Parson-Quintana, Beverly; Ramirez, Lucia; Rash, Sam; Retterer, James; Ricke, Darryl O.; Robinson, Donna L.; Rodriguez, Alex; Salamov, Asaf; Saunders, Elizabeth H.; Scott, Duncan; Shough, Timothy; Stallings, Raymond L.; Stalvey, Malinda; Sutherland, Robert D.; Tapia, Roxanne; Tesmer, Judith G.; Thayer, Nina; Thompson, Linda S.; Tice, Hope; Torney, David C.; Tran-Gyamfi, Mary; Tsai, Ming; Ulanovsky, Levy E.; Ustaszewska, Anna; Vo, Nu; White, P. Scott; Williams, Albert L.; Wills, Patricia L.; Wu, Jung-Rung; Wu, Kevin; Yang, Joan; DeJong, Pieter; Bruce, David; Doggett, Norman; Deaven, Larry; Schmutz, Jeremy; Grimwood, Jane; Richardson, Paul; et al.

    2004-01-01

    We report here the 78,884,754 base pairs of finished human chromosome 16 sequence, representing over 99.9 percent of its euchromatin. Manual annotation revealed 880 protein coding genes confirmed by 1,637 aligned transcripts, 19 tRNA genes, 341 pseudogenes and 3 RNA pseudogenes. These genes include metallothionein, cadherin and iroquois gene families, as well as the disease genes for polycystic kidney disease and acute myelomonocytic leukemia. Several large-scale structural polymorphisms spanning hundreds of kilobasepairs were identified and result in gene content differences across humans. One of the unique features of chromosome 16 is its high level of segmental duplication, ranked among the highest of the human autosomes. While the segmental duplications are enriched in the relatively gene poor pericentromere of the p-arm, some are involved in recent gene duplication and conversion events which are likely to have had an impact on the evolution of primates and human disease susceptibility.

  18. Defining Human Failure Events for Petroleum Risk Analysis

    SciTech Connect (OSTI)

    Ronald L. Boring; Knut Øien

    2014-06-01

    In this paper, an identification and description of barriers and human failure events (HFEs) for human reliability analysis (HRA) is performed. The barriers, called target systems, are identified from risk significant accident scenarios represented as defined situations of hazard and accident (DSHAs). This report serves as the foundation for further work to develop petroleum HFEs compatible with the SPAR-H method and intended for reuse in future HRAs.

  19. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in

  20. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in

  1. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in

  2. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in

  3. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in

  4. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in

  5. Solar Energy Education. Humanities: activities and teacher's guide. Field

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    test edition (Technical Report) | SciTech Connect Humanities: activities and teacher's guide. Field test edition Citation Details In-Document Search Title: Solar Energy Education. Humanities: activities and teacher's guide. Field test edition × You are accessing a document from the Department of Energy's (DOE) SciTech Connect. This site is a product of DOE's Office of Scientific and Technical Information (OSTI) and is provided as a public service. Visit OSTI to utilize additional

  6. UPDATING THE NRC GUIDANCE FOR HUMAN FACTORS ENGINEERING REVIEWS.

    SciTech Connect (OSTI)

    O HARA,J.M.; BROWN,W.S.; HIGGINS,J.C.; PERSENSKY,J.J.; LEWIS,P.M.; BONGARRA,J.

    2002-09-15

    The U.S. Nuclear Regulatory Commission (NRC) reviews the human factors engineering (HFE) aspects of nuclear plants. NUREG-0800 (Standard Review Plan), Chapter 18, ''Human Factors Engineering,'' is the principal NRC staff guidance document. Two main documents provide the review criteria to support the evaluations. The HFE Program Review Model (NUREG-0711) addresses the design process from planning to verification and validation to design implementation. The Human-System Interface Design Review Guidelines (NUREG-0700) provides the guidelines for the review of the HFE aspects of human-system interface technology, such as alarms, information systems, controls, and control room design. Since these documents were published in 1994 and 1996 respectively, they have been used by NRC staff, contractors, nuclear industry organizations, as well as by numerous organizations outside the nuclear industry. Using feedback from users and NRC research conducted in recent years, both documents have been revised and updated. This was done to ensure that they remain state-of-the-art evaluation tools for changing nuclear industry issues and emerging technologies. This paper describes the methodology used to revise and update the documents and summarizes the changes made to each and their current contents. Index Terms for this report are: Control system human factors, Ergonomics, Human factors, Nuclear power generation safety.

  7. Human factors engineering report for the cold vacuum drying facility

    SciTech Connect (OSTI)

    IMKER, F.W.

    1999-06-30

    The purpose of this report is to present the results and findings of the final Human Factors Engineering (HFE) technical analysis and evaluation of the Cold Vacuum Drying Facility (CVDF). Ergonomics issues are also addressed in this report, as appropriate. This report follows up and completes the preliminary work accomplished and reported by the Preliminary HFE Analysis report (SNF-2825, Spent Nuclear Fuel Project Cold Vacuum Drying Facility Human Factors Engineering Analysis: Results and Findings). This analysis avoids redundancy of effort except for ensuring that previously recommended HFE design changes have not affected other parts of the system. Changes in one part of the system may affect other parts of the system where those changes were not applied. The final HFE analysis and evaluation of the CVDF human-machine interactions (HMI) was expanded to include: the physical work environment, human-computer interface (HCI) including workstation and software, operator tasks, tools, maintainability, communications, staffing, training, and the overall ability of humans to accomplish their responsibilities, as appropriate. Key focal areas for this report are the process bay operations, process water conditioning (PWC) skid, tank room, and Central Control Room operations. These key areas contain the system safety-class components and are the foundation for the human factors design basis of the CVDF.

  8. "Human-on-a-Chip" Technology Could Replace Animal Testing | Department...

    Broader source: Energy.gov (indexed) [DOE]

    Maren Hunsberger takes us "Inside the Lab" to learn about the "human-on-a-chip" project. | ... viruses, or drugs on human beings without resorting to animal or even human test subjects? ...

  9. MEMO RANUM FOR HUMAN RESOURCES DIRECTORS FROM: S~J\O~TOR OFFICE b:\HUMAN CAPITAL MANAGEMENT

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    0 MEMO RANUM FOR HUMAN RESOURCES DIRECTORS FROM: S~J\O~TOR OFFICE b:\HUMAN CAPITAL MANAGEMENT SUBJECT: GUIDANCE MEMORANDUM #13 REEMPLOYMENT PRIORITY LIST SELECTIONS This memorandum provides guidance for using the Department of Energy's (DOE) Reemployment Priority List (RPL). The DOE RPL is designed to provide priority consideration to employees who have lost their jobs through reduction in force. or who have fully recovered from a compensable injury after more than 1 year. Employees may only

  10. Crossreactivity of a human autoimmune TCR is dominated by a single...

    Office of Scientific and Technical Information (OSTI)

    Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop Citation Details In-Document Search Title: Crossreactivity of a human autoimmune TCR is dominated ...

  11. MEMO RANUM FOR HUMAN RESOURCES DIRECTORS FROM: S~J\\O~TOR OFFICE...

    Broader source: Energy.gov (indexed) [DOE]

    0 MEMO RANUM FOR HUMAN RESOURCES DIRECTORS FROM: SJOTOR OFFICE b:HUMAN CAPITAL MANAGEMENT SUBJECT: GUIDANCE MEMORANDUM 13 REEMPLOYMENT PRIORITY LIST SELECTIONS This memorandum ...

  12. Microsoft Word - DOE Human Capital Strategic Plan 2011-2015.docx

    Broader source: Energy.gov (indexed) [DOE]

    DOE HUMAN CAPITAL STRATEGIC PLAN FY 2011 - FY 2015 DOE HUMAN CAPITAL STRATEGIC PLAN FY 2011 - FY 2015 TABLE OF CONTENTS EXECUTIVE SUMMARY ......

  13. Human Subjects Research Database (HSRD) | U.S. DOE Office of...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Subjects Research Database (HSRD) Human Subjects Protection Program (HSPP) HSPP Home About Institutional Review Boards (IRBs) Education and Resources CITI Courses DOE ...

  14. For Prospective Human Subjects | U.S. DOE Office of Science ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Prospective Human Subjects Human Subjects Protection Program (HSPP) HSPP Home About For Researchers For IRB Managers Administrators For IRB Members For Institutional Officials ...

  15. Human Resources Advisory Office | U.S. DOE Office of Science...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources Advisory Office Management OM Home About Program Direction and Analysis Human Resources Advisory Office Administration Contact Information Management U.S. ...

  16. Simulation and Non-Simulation Based Human Reliability Analysis Approaches

    SciTech Connect (OSTI)

    Boring, Ronald Laurids; Shirley, Rachel Elizabeth; Joe, Jeffrey Clark; Mandelli, Diego

    2014-12-01

    Part of the U.S. Department of Energy’s Light Water Reactor Sustainability (LWRS) Program, the Risk-Informed Safety Margin Characterization (RISMC) Pathway develops approaches to estimating and managing safety margins. RISMC simulations pair deterministic plant physics models with probabilistic risk models. As human interactions are an essential element of plant risk, it is necessary to integrate human actions into the RISMC risk model. In this report, we review simulation-based and non-simulation-based human reliability assessment (HRA) methods. Chapter 2 surveys non-simulation-based HRA methods. Conventional HRA methods target static Probabilistic Risk Assessments for Level 1 events. These methods would require significant modification for use in dynamic simulation of Level 2 and Level 3 events. Chapter 3 is a review of human performance models. A variety of methods and models simulate dynamic human performance; however, most of these human performance models were developed outside the risk domain and have not been used for HRA. The exception is the ADS-IDAC model, which can be thought of as a virtual operator program. This model is resource-intensive but provides a detailed model of every operator action in a given scenario, along with models of numerous factors that can influence operator performance. Finally, Chapter 4 reviews the treatment of timing of operator actions in HRA methods. This chapter is an example of one of the critical gaps between existing HRA methods and the needs of dynamic HRA. This report summarizes the foundational information needed to develop a feasible approach to modeling human interactions in the RISMC simulations.

  17. Assessing human rights impacts in corporate development projects

    SciTech Connect (OSTI)

    Salcito, Kendyl; University of Basel, P.O. Box, CH-4003 Basel; NomoGaia, 1900 Wazee Street, Suite 303, Denver, CO 80202; NewFields, LLC, Denver, CO 80202 ; Utzinger, Jrg; University of Basel, P.O. Box, CH-4003 Basel ; Weiss, Mitchell G.; Mnch, Anna K.; Singer, Burton H.; Krieger, Gary R.; Wielga, Mark; NewFields, LLC, Denver, CO 80202

    2013-09-15

    Human rights impact assessment (HRIA) is a process for systematically identifying, predicting and responding to the potential impact on human rights of a business operation, capital project, government policy or trade agreement. Traditionally, it has been conducted as a desktop exercise to predict the effects of trade agreements and government policies on individuals and communities. In line with a growing call for multinational corporations to ensure they do not violate human rights in their activities, HRIA is increasingly incorporated into the standard suite of corporate development project impact assessments. In this context, the policy world's non-structured, desk-based approaches to HRIA are insufficient. Although a number of corporations have commissioned and conducted HRIA, no broadly accepted and validated assessment tool is currently available. The lack of standardisation has complicated efforts to evaluate the effectiveness of HRIA as a risk mitigation tool, and has caused confusion in the corporate world regarding company duties. Hence, clarification is needed. The objectives of this paper are (i) to describe an HRIA methodology, (ii) to provide a rationale for its components and design, and (iii) to illustrate implementation of HRIA using the methodology in two selected corporate development projectsa uranium mine in Malawi and a tree farm in Tanzania. We found that as a prognostic tool, HRIA could examine potential positive and negative human rights impacts and provide effective recommendations for mitigation. However, longer-term monitoring revealed that recommendations were unevenly implemented, dependent on market conditions and personnel movements. This instability in the approach to human rights suggests a need for on-going monitoring and surveillance. -- Highlights: We developed a novel methodology for corporate human rights impact assessment. We piloted the methodology on two corporate projectsa mine and a plantation. Human rights

  18. Shotgun metaproteomics of the human distal gut microbiota

    SciTech Connect (OSTI)

    VerBerkmoes, N.C.; Russell, A.L.; Shah, M.; Godzik, A.; Rosenquist, M.; Halfvarsson, J.; Lefsrud, M.G.; Apajalahti, J.; Tysk, C.; Hettich, R.L.; Jansson, Janet K.

    2008-10-15

    The human gut contains a dense, complex and diverse microbial community, comprising the gut microbiome. Metagenomics has recently revealed the composition of genes in the gut microbiome, but provides no direct information about which genes are expressed or functioning. Therefore, our goal was to develop a novel approach to directly identify microbial proteins in fecal samples to gain information about the genes expressed and about key microbial functions in the human gut. We used a non-targeted, shotgun mass spectrometry-based whole community proteomics, or metaproteomics, approach for the first deep proteome measurements of thousands of proteins in human fecal samples, thus demonstrating this approach on the most complex sample type to date. The resulting metaproteomes had a skewed distribution relative to the metagenome, with more proteins for translation, energy production and carbohydrate metabolism when compared to what was earlier predicted from metagenomics. Human proteins, including antimicrobial peptides, were also identified, providing a non-targeted glimpse of the host response to the microbiota. Several unknown proteins represented previously undescribed microbial pathways or host immune responses, revealing a novel complex interplay between the human host and its associated microbes.

  19. Interim report of the Advisory Committee on human radiation experiments

    SciTech Connect (OSTI)

    Not Available

    1994-10-21

    The Advisory Committee on Human Radiation Experiments was created by President Clinton to advise the Human Radiation Interagency Working Group on the ethical and scientific criteria applicable to human radiation experiments carried out or sponsored by the U.S. Government. The Committee seeks to answer several fundamental question: What ethics criteria should be used to evaluate human radiation experiments? What was the Federal Government`s role in human radiation experiments? What are the criteria for determining appropriate Federal responses where wrongs or harms have occurred? What lessons learned from studying past and present research standards and practices should be applied to the future? The Committee has been gathering vast amounts of information and working to render it orderly and accessible. In the next six months, the Committee will continue with the tasks of data gathering and organizing. The focus of the work, however, will be developing criteria for judging historical and contemporary experiments, policies, and procedures, as well as criteria for remedies that may be appropriate where harms or wrongs have ocurred. Based on findings, the Committee will make specific recommendations regarding policies for the future.

  20. Allometric scaling for predicting human clearance of bisphenol A

    SciTech Connect (OSTI)

    Collet, Séverine H. Picard-Hagen, Nicole Lacroix, Marlène Z. Puel, Sylvie Viguié, Catherine Bousquet-Melou, Alain Toutain, Pierre-Louis Gayrard, Véronique

    2015-05-01

    The investigation of interspecies differences in bisphenol A (BPA) pharmacokinetics (PK) may be useful for translating findings from animal studies to humans, identifying major processes involved in BPA clearance mechanisms, and predicting BPA PK parameters in man. For the first time, a large range of species in terms of body weight, from 0.02 kg (mice) to 495 kg (horses) was used to predict BPA clearance in man by an allometric approach. BPA PK was evaluated after intravenous administration of BPA in horses, sheep, pigs, dogs, rats and mice. A non-compartmental analysis was used to estimate plasma clearance and steady state volume of distribution and predict BPA PK parameters in humans from allometric scaling. In all the species investigated, BPA plasma clearance was high and of the same order of magnitude as their respective hepatic blood flow. By an allometric scaling, the human clearance was estimated to be 1.79 L/min (equivalent to 25.6 mL/kg.min) with a 95% prediction interval of 0.36 to 8.83 L/min. Our results support the hypothesis that there are highly efficient and hepatic mechanisms of BPA clearance in man. - Highlights: • Allometric scaling was used to predict BPA pharmacokinetic parameters in humans. • In all species, BPA plasma clearance approached hepatic blood flow. • Human BPA clearance was estimated to be 1.79 L/min.

  1. Athletic equipment microbiota are shaped by interactions with human skin

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wood, Mariah; Gibbons, Sean M.; Lax, Simon; Eshoo-Anton, Tifani W.; Owens, Sarah M.; Kennedy, Suzanne; Gilbert, Jack A.; Hampton-Marcell, Jarrad T.

    2015-06-19

    Background: Americans spend the vast majority of their lives in built environments. Even traditionally outdoor pursuits, such as exercising, are often now performed indoors. Bacteria that colonize these indoor ecosystems are primarily derived from the human microbiome. The modes of human interaction with indoor surfaces and the physical conditions associated with each surface type determine the steady-state ecology of the microbial community. Results: Bacterial assemblages associated with different surfaces in three athletic facilities, including floors, mats, benches, free weights, and elliptical handles, were sampled every other hour (8 am to 6 pm) for 2 days. Surface and equipment type hadmore » a stronger influence on bacterial community composition than the facility in which they were housed. Surfaces that were primarily in contact with human skin exhibited highly dynamic bacterial community composition and non-random co-occurrence patterns, suggesting that different host microbiomes—shaped by selective forces—were being deposited on these surfaces through time. Bacterial assemblages found on the floors and mats changed less over time, and species co-occurrence patterns appeared random, suggesting more neutral community assembly. Conclusions: These longitudinal patterns highlight the dramatic turnover of microbial communities on surfaces in regular contact with human skin. By uncovering these longitudinal patterns, this study promotes a better understanding of microbe-human interactions within the built environment.« less

  2. IDHEAS – A NEW APPROACH FOR HUMAN RELIABILITY ANALYSIS

    SciTech Connect (OSTI)

    G. W. Parry; J.A Forester; V.N. Dang; S. M. L. Hendrickson; M. Presley; E. Lois; J. Xing

    2013-09-01

    This paper describes a method, IDHEAS (Integrated Decision-Tree Human Event Analysis System) that has been developed jointly by the US NRC and EPRI as an improved approach to Human Reliability Analysis (HRA) that is based on an understanding of the cognitive mechanisms and performance influencing factors (PIFs) that affect operator responses. The paper describes the various elements of the method, namely the performance of a detailed cognitive task analysis that is documented in a crew response tree (CRT), and the development of the associated time-line to identify the critical tasks, i.e. those whose failure results in a human failure event (HFE), and an approach to quantification that is based on explanations of why the HFE might occur.

  3. Recombinant human bone morphogenetic protein induces bone formation

    SciTech Connect (OSTI)

    Wang, E.A.; Rosen, V.; D'Alessandro, J.S.; Bauduy, M.; Cordes, P.; Harada, T.; Israel, D.I.; Hewick, R.M.; Kerns, K.M.; LaPan, P.; Luxenberg, D.P.; McQuaid, D.; Moutsatsos, I.K.; Nove, J.; Wozney, J.M. )

    1990-03-01

    The authors have purified and characterized active recombinant human bone morphogenetic protein (BMP) 2A. Implantation of the recombinant protein in rats showed that a single BMP can induce bone formation in vivo. A dose-response and time-course study using the rat ectopic bone formation assay revealed that implantation of 0.5-115 {mu}g of partially purified recombinant human BMP-2A resulted in cartilage by day 7 and bone formation by day 14. The time at which bone formation occurred was dependent on the amount of BMP-2A implanted; at high doses bone formation could be observed at 5 days. The cartilage- and bone-inductive activity of the recombinant BMP-2A is histologically indistinguishable from that of bone extracts. Thus, recombinant BMP-2A has therapeutic potential to promote de novo bone formation in humans.

  4. The Human Genome Initiative of the Department of Energy

    DOE R&D Accomplishments [OSTI]

    1988-01-01

    The structural characterization of genes and elucidation of their encoded functions have become a cornerstone of modern health research, biology and biotechnology. A genome program is an organized effort to locate and identify the functions of all the genes of an organism. Beginning with the DOE-sponsored, 1986 human genome workshop at Santa Fe, the value of broadly organized efforts supporting total genome characterization became a subject of intensive study. There is now national recognition that benefits will rapidly accrue from an effective scientific infrastructure for total genome research. In the US genome research is now receiving dedicated funds. Several other nations are implementing genome programs. Supportive infrastructure is being improved through both national and international cooperation. The Human Genome Initiative of the Department of Energy (DOE) is a focused program of Resource and Technology Development, with objectives of speeding and bringing economies to the national human genome effort. This report relates the origins and progress of the Initiative.

  5. (Meeting on human dimensions of global environmental change)

    SciTech Connect (OSTI)

    Rayner, S.

    1990-12-18

    Traveler attended the meeting of the Standing Committee on the Human Dimensions of Global Environmental Change of the International Social Science Council (ISSC) and the Scientific Symposium organized by the Standing Committee. The purpose of the meeting and symposium was to discuss the Draft Framework and the Workplan of the Standing Committee prior to its presentation to the 1990 Congress of the ISSC on November 28--30, 1990. The meetings indicate that ORNL Global Environmental Studies Center is on the international leading edge of human dimensions research, except in the area of human dimensions data systems. This weakness could be rectified by close collaboration with the efforts of the Consortium for International Earth Science Information Network (CIESIN) in Michigan.

  6. Toxicological and epidemiological aspects of global warming on human health

    SciTech Connect (OSTI)

    Ando, M.; Yamamoto, S.; Wakamatsu, K.; Kawahara, I.; Asanuma, S.

    1996-12-31

    Since human activities are responsible for anthropogenic greenhouse gases emissions, climate models project an increase in the global surface temperature of 0.9 C to 4.0 C by 2100. For human health, it is projected that global warming may have a critical effect on the increased periods of severe heat stress in summer throughout the world. Global warming may have a critical issue on the increased periods of severe heat stress that have a potential impact on peroxidative damage in humans and animals. Lipid peroxidative damage is markedly related to GSH peroxidase activities, therefore the study was carried out to analyze the relationship between biochemical adaptability and the lipid peroxidative damage especially intracellular structure, such as mitochondria and endoplasmic reticulum depending on the exposure time of heat stress.

  7. Continuous human cell lines and method of making same

    DOE Patents [OSTI]

    Stampfer, Martha R.

    1989-01-01

    Substantially genetically stable continuous human cell lines derived from normal human mammary epithelial cells (HMEC) and processes for making and using the same. In a preferred embodiment, the cell lines are derived by treating normal human mammary epithelial tissue with a chemical carcinogen such as benzo[a]pyrene. The novel cell lines serve as useful substrates for elucidating the potential effects of a number of toxins, carcinogens and mutagens as well as of the addition of exogenous genetic material. The autogenic parent cells from which the cell lines are derived serve as convenient control samples for testing. The cell lines are not neoplastically transformed, although they have acquired several properties which distinguish them from their normal progenitors.

  8. Continuous human cell lines and method of making same

    DOE Patents [OSTI]

    Stampfer, M.R.

    1985-07-01

    Substantially genetically stable continuous human cell lines derived from normal human mammary epithelial cells (HMEC) and processes for making and using the same. In a preferred embodiment, the cell lines are derived by treating normal human mammary epithelial tissue with a chemical carcinogen such as benzo(a)pyrene. The novel cell lines serve as useful substrates for elucidating the potential effects of a number of toxins, carcinogens and mutagens as well as of the addition of exogenous genetic material. The autogenic parent cells from which the cell lines are derived serve as convenient control samples for testing. The cell lines are not neoplastically transformed, although they have acquired several properties which distinguish them from their normal progenitors. 2 tabs.

  9. Understanding mutagenesis through delineation of mutational signatures in human cancer

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Petljak, Mia; Alexandrov, Ludmil B.

    2016-05-04

    Each individual cell within a human body acquires a certain number of somatic mutations during a course of its lifetime. These mutations originate from a wide spectra of both endogenous and exogenous mutational processes that leave distinct patterns of mutations, termed mutational signatures, embedded within the genomes of all cells. In recent years, the vast amount of data produced by sequencing of cancer genomes was coupled with novel mathematical models and computational tools to generate the first comprehensive map of mutational signatures in human cancer. Up to date, >30 distinct mutational signatures have been identified, and etiologies have been proposedmore » for many of them. This paper provides a brief historical background on examination of mutational patterns in human cancer, summarizes the knowledge accumulated since introducing the concept of mutational signatures and discusses their future potential applications and perspectives within the field.« less

  10. Chemicals identified in human biological media: a data base. Third annual report, October 1981

    SciTech Connect (OSTI)

    Cone, M.V.; Baldauf, M.F.; Martin, F.M.

    1981-12-01

    Data from almost 1600 of the 3800 body-burden documents collected to date have been entered in the data base as of October 1981. The emphasis on including recent literature and significant research documents has resulted in a chronological mix of articles from 1974 to the present. When body-burden articles are identified, data are extracted and entered in the data base by chemical and tissue/body fluid. Each data entry comprises a single record (or line entry) and is assigned a record number. If a particular document deals with more than one chemical and/or tissue, there will be multiple records for that document. For example, a study of 5 chemicals in each of 3 tissues has 15 different records (or 15 line entries) in the data base with 15 record numbers. Record numbers are assigned consecutively throughout the entire data base and appear in the upper left corner of the first column for each record.

  11. Apolipoprotein E promotes lipid accumulation and differentiation in human adipocytes

    SciTech Connect (OSTI)

    Lasrich, Dorothee; Bartelt, Alexander; Grewal, Thomas; Heeren, Joerg

    2015-09-10

    Several studies in mice indicate a role for apolipoprotein E (APOE) in lipid accumulation and adipogenic differentiation in adipose tissue. However, little is yet known if APOE functions in a similar manner in human adipocytes. This prompted us to compare lipid loading and expression of adipocyte differentiation markers in APOE-deficient and control adipocytes using the differentiated human mesenchymal stem cell line hMSC-Tert as well as primary human and mouse adipocytes as model systems. Differentiated hMSC-Tert were stably transduced with or without siRNA targeting APOE while murine adipocytes were isolated from wild type and Apoe knockout mice. Human APOE knockdown hMSC-Tert adipocytes accumulated markedly less triglycerides compared to control cells. This correlated with strongly decreased gene expression levels of adipocyte markers such as adiponectin (ADIPOQ) and fatty acid binding protein 4 (FABP4) as well as the key transcription factor driving adipocyte differentiation, peroxisome proliferator activator receptor gamma (PPARG), in particular the PPARG2 isoform. Similarly, differentiation of murine Apoe-deficient adipocytes was characterized by reduced gene expression of Adipoq, Fabp4 and Pparg. Interestingly, incubation of APOE-deficient hMSC-Tert adipocytes with conditioned media from APOE3-overexpressing adipocytes or APOE-containing Very Low Density Lipoprotein (VLDL) partially restored triglyceride accumulation, but were unable to induce adipocyte differentiation, as judged by expression of adipocyte markers. Taken together, depletion of endogenous APOE in human adipocytes severely impairs lipid accumulation, which is associated with an inability to initiate differentiation. - Highlights: • Immortalized human mesenchymal stem cells were used to study adipocyte development. • Knockdown of endogenous APOE lead to impaired lipid accumulation and adipogenesis. • APOE supplementation partially restored lipid accumulation but not differentiation.

  12. Human Factors Considerations in New Nuclear Power Plants: Detailed Analysis.

    SciTech Connect (OSTI)

    OHara,J.; Higgins, J.; Brown, W.; Fink, R.

    2008-02-14

    This Nuclear Regulatory Commission (NRC) sponsored study has identified human-performance issues in new and advanced nuclear power plants. To identify the issues, current industry developments and trends were evaluated in the areas of reactor technology, instrumentation and control technology, human-system integration technology, and human factors engineering (HFE) methods and tools. The issues were organized into seven high-level HFE topic areas: Role of Personnel and Automation, Staffing and Training, Normal Operations Management, Disturbance and Emergency Management, Maintenance and Change Management, Plant Design and Construction, and HFE Methods and Tools. The issues where then prioritized into four categories using a 'Phenomena Identification and Ranking Table' methodology based on evaluations provided by 14 independent subject matter experts. The subject matter experts were knowledgeable in a variety of disciplines. Vendors, utilities, research organizations and regulators all participated. Twenty issues were categorized into the top priority category. This Brookhaven National Laboratory (BNL) technical report provides the detailed methodology, issue analysis, and results. A summary of the results of this study can be found in NUREG/CR-6947. The research performed for this project has identified a large number of human-performance issues for new control stations and new nuclear power plant designs. The information gathered in this project can serve as input to the development of a long-term strategy and plan for addressing human performance in these areas through regulatory research. Addressing human-performance issues will provide the technical basis from which regulatory review guidance can be developed to meet these challenges. The availability of this review guidance will help set clear expectations for how the NRC staff will evaluate new designs, reduce regulatory uncertainty, and provide a well-defined path to new nuclear power plant licensing.

  13. In silico prediction of xenobiotic metabolism in humans

    SciTech Connect (OSTI)

    Mu, Fangping

    2009-01-01

    Xenobiotic metabolism in humans is catalyzed by a few enzymes with broad substrate specificities, which provide the overall broad chemical specificity for nearly all xenobiotics that humans encounter. Xenobiotic metabolism are classified into functional group biotransformations. Based on bona fide reactions and negative examples for each reaction class, support vector machine (SVM) classifiers are built. The input to SVM is a set of atomic and molecular features to define the electrostatic, steric, energetic, geometrical and topological environment of the atoms in the reaction center under the molecule. Results show that the overall sensitivity and specificity of classifiers is around 87%.

  14. Accommodating complexity and human behaviors in decision analysis.

    SciTech Connect (OSTI)

    Backus, George A.; Siirola, John Daniel; Schoenwald, David Alan; Strip, David R.; Hirsch, Gary B.; Bastian, Mark S.; Braithwaite, Karl R.; Homer, Jack

    2007-11-01

    This is the final report for a LDRD effort to address human behavior in decision support systems. One sister LDRD effort reports the extension of this work to include actual human choices and additional simulation analyses. Another provides the background for this effort and the programmatic directions for future work. This specific effort considered the feasibility of five aspects of model development required for analysis viability. To avoid the use of classified information, healthcare decisions and the system embedding them became the illustrative example for assessment.

  15. Human choice and climate change. Four volume set

    SciTech Connect (OSTI)

    Rayner, S.; Malone, E.L.

    1997-12-31

    The four-volume set assesses social science research relevant to global climate change from a wide-ranging interdisciplinary perspective. Taking human choice within social institutions as the starting point, noted researchers examine climate change issues in the context of societal issues such as population and consumption; cultural, institutional, and economic arrangements for human well-being; and the social processes by which decisions are made from local to global levels. This four-volume assessment is intended to complement the work of the intergovernmental Panel on Climate Change.

  16. THE VALIDITY OF HUMAN AND COMPUTERIZED WRITING ASSESSMENT

    SciTech Connect (OSTI)

    Ronald L. Boring

    2005-09-01

    This paper summarizes an experiment designed to assess the validity of essay grading between holistic and analytic human graders and a computerized grader based on latent semantic analysis. The validity of the grade was gauged by the extent to which the students knowledge of the topic correlated with the graders expert knowledge. To assess knowledge, Pathfinder networks were generated by the student essay writers, the holistic and analytic graders, and the computerized grader. It was found that the computer generated grades more closely matched the definition of valid grading than did human generated grades.

  17. Depleted uranium human health risk assessment, Jefferson Proving Ground, Indiana

    SciTech Connect (OSTI)

    Ebinger, M.H.; Hansen, W.R.

    1994-04-29

    The risk to human health from fragments of depleted uranium (DU) at Jefferson Proving Ground (JPG) was estimated using two types of ecosystem pathway models. A steady-state, model of the JPG area was developed to examine the effects of DU in soils, water, and vegetation on deer that were hunted and consumed by humans. The RESRAD code was also used to estimate the effects of farming the impact area and consuming the products derived from the farm. The steady-state model showed that minimal doses to humans are expected from consumption of deer that inhabit the impact area. Median values for doses to humans range from about 1 mrem ({plus_minus}2.4) to 0.04 mrem ({plus_minus}0.13) and translate to less than 1 {times} 10{sup {minus}6} detriments (excess cancers) in the population. Monte Carlo simulation of the steady-state model was used to derive the probability distributions from which the median values were drawn. Sensitivity analyses of the steady-state model showed that the amount of DU in airborne dust and, therefore, the amount of DU on the vegetation surface, controlled the amount of DU ingested by deer and by humans. Human doses from the RESRAD estimates ranged from less than 1 mrem/y to about 6.5 mrem/y in a hunting scenario and subsistence fanning scenario, respectively. The human doses exceeded the 100 mrem/y dose limit when drinking water for the farming scenario was obtained from the on-site aquifer that was presumably contaminated with DU. The two farming scenarios were unrealistic land uses because the additional risk to humans due to unexploded ordnance in the impact area was not figured into the risk estimate. The doses estimated with RESRAD translated to less than 1 {times} 10{sup {minus}6} detriments to about 1 {times} 10{sup {minus}3} detriments. The higher risks were associated only with the farming scenario in which drinking water was obtained on-site.

  18. Lessons Learned Concerning the Human Element in Events and Training

    SciTech Connect (OSTI)

    Michael D. Sandvig

    2006-02-01

    As the number and complexity of responses to hazardous material incidents have increased, government regulators have implemented a national incident command system, bolstered by a host of protective measures and response equipment. Special advanced technical equipment has also been developed and made available to on-scene responders and command staff. Yet with all the investment in organizational and technical advance, the human element of emergency response remains critical and also needs our continued attention to ensure effective operation and success. This paper focuses on lessons learned from radiological events and training exercises that pertain to these human elements.

  19. Ethical issues in international collaborative research on the human genome: The HGP and the HGDP

    SciTech Connect (OSTI)

    Knoppers, B.M.; Hirtle, M.; Lormeau, S.

    1996-06-01

    This special feature describes the ethical issues in international collaborative research on the human genome, both regarding the Human Genome Project (HGP), which is concerned with genetic mapping, and the Human Genome Diversity Project (HGDP), which is an effort to document the genetic variation of the human species worldwide. 88 refs.

  20. Psychosocial and Cultural Modeling in Human Computation Systems: A Gamification Approach

    SciTech Connect (OSTI)

    Sanfilippo, Antonio P.; Riensche, Roderick M.; Haack, Jereme N.; Butner, R. Scott

    2013-11-20

    “Gamification”, the application of gameplay to real-world problems, enables the development of human computation systems that support decision-making through the integration of social and machine intelligence. One of gamification’s major benefits includes the creation of a problem solving environment where the influence of cognitive and cultural biases on human judgment can be curtailed through collaborative and competitive reasoning. By reducing biases on human judgment, gamification allows human computation systems to exploit human creativity relatively unhindered by human error. Operationally, gamification uses simulation to harvest human behavioral data that provide valuable insights for the solution of real-world problems.

  1. The human factors of quality and QA in R D environments

    SciTech Connect (OSTI)

    Hill, S.G.

    1990-01-01

    Achieving quality is a human activity. It is therefore important to consider the human in the design, development and evaluation of work processes and environments in an effort to enhance human performance and minimize error. It is also important to allow for individual differences when considering human factors issues. Human Factors is the field of study which can provide information on integrating the human into the system. Human factors and quality are related for the customer of R D work, R D personnel who perform the work, and the quality professional who overviews the process of quality in the work. 18 refs., 1 fig.

  2. Human performance modeling for system of systems analytics :soldier fatigue.

    SciTech Connect (OSTI)

    Lawton, Craig R.; Campbell, James E.; Miller, Dwight Peter

    2005-10-01

    The military has identified Human Performance Modeling (HPM) as a significant requirement and challenge of future systems modeling and analysis initiatives as can be seen in the Department of Defense's (DoD) Defense Modeling and Simulation Office's (DMSO) Master Plan (DoD 5000.59-P 1995). To this goal, the military is currently spending millions of dollars on programs devoted to HPM in various military contexts. Examples include the Human Performance Modeling Integration (HPMI) program within the Air Force Research Laboratory, which focuses on integrating HPMs with constructive models of systems (e.g. cockpit simulations) and the Navy's Human Performance Center (HPC) established in September 2003. Nearly all of these initiatives focus on the interface between humans and a single system. This is insufficient in the era of highly complex network centric SoS. This report presents research and development in the area of HPM in a system-of-systems (SoS). Specifically, this report addresses modeling soldier fatigue and the potential impacts soldier fatigue can have on SoS performance.

  3. Comparative mutagenesis of human cells in vivo and in vitro

    SciTech Connect (OSTI)

    Thilly, W.G.

    1992-05-01

    This report discusses measuring methods of point mutations; high density cell cultures for low dose studies; measurement and sequence determination of mutations in DNA; the mutational spectra of styrene oxide and ethlyene oxide in TK-6 cells; mutational spectrum of Cr in human lymphoblast cells; mutational spectra of radon in TK-6 cells; and the mutational spectra of smokeless tobacco. (CBS)

  4. Human genome program report. Part 1, overview and progress

    SciTech Connect (OSTI)

    1997-11-01

    This report contains Part 1 of a two-part report to reflect research and progress in the U.S. Department of Energy Human Genome Program from 1994 through 1996, with specified updates made just before publication. Part 1 consists of the program overview and report on progress.

  5. A Research Roadmap for Computation-Based Human Reliability Analysis

    SciTech Connect (OSTI)

    Boring, Ronald; Mandelli, Diego; Joe, Jeffrey; Smith, Curtis; Groth, Katrina

    2015-08-01

    The United States (U.S.) Department of Energy (DOE) is sponsoring research through the Light Water Reactor Sustainability (LWRS) program to extend the life of the currently operating fleet of commercial nuclear power plants. The Risk Informed Safety Margin Characterization (RISMC) research pathway within LWRS looks at ways to maintain and improve the safety margins of these plants. The RISMC pathway includes significant developments in the area of thermalhydraulics code modeling and the development of tools to facilitate dynamic probabilistic risk assessment (PRA). PRA is primarily concerned with the risk of hardware systems at the plant; yet, hardware reliability is often secondary in overall risk significance to human errors that can trigger or compound undesirable events at the plant. This report highlights ongoing efforts to develop a computation-based approach to human reliability analysis (HRA). This computation-based approach differs from existing static and dynamic HRA approaches in that it: (i) interfaces with a dynamic computation engine that includes a full scope plant model, and (ii) interfaces with a PRA software toolset. The computation-based HRA approach presented in this report is called the Human Unimodels for Nuclear Technology to Enhance Reliability (HUNTER) and incorporates in a hybrid fashion elements of existing HRA methods to interface with new computational tools developed under the RISMC pathway. The goal of this research effort is to model human performance more accurately than existing approaches, thereby minimizing modeling uncertainty found in current plant risk models.

  6. Human factors evaluation of teletherapy: Literature review. Volume 5

    SciTech Connect (OSTI)

    Henriksen, K.; Kaye, R.D.; Jones, R.; Morisseau, D.S.; Serig, D.L.

    1995-07-01

    A series of human factors evaluations were undertaken to better understand the contributing factors to human error in the teletherapy environment. Teletherapy is a multidisciplinary methodology for treating cancerous tissue through selective exposure to an external beam of ionizing radiation. A team of human factors specialists, assisted by a panel of radiation oncologists, medical physicists, and radiation therapists, conducted site visits to radiation oncology departments at community hospitals, university centers, and free-standing clinics. A function and task analysis was performed initially to guide subsequent evaluations in the areas of workplace environment, system-user interfaces, procedures, training, and organizational practices. To further acquire an in-depth and up-to-date understanding of the practice of teletherapy in support of these evaluations, a systematic literature review was conducted. Factors that have a potential impact on the accuracy of treatment delivery were of primary concern. The present volume is the literature review. The volume starts with an overview of the multiphased nature of teletherapy, and then examines the requirement for precision, the increasing role of quality assurance, current conceptualizations of human error, and the role of system factors such as the workplace environment, user-system interfaces, procedures, training, and organizational practices.

  7. Human Factors Evaluation of Advanced Electric Power Grid Visualization Tools

    SciTech Connect (OSTI)

    Greitzer, Frank L.; Dauenhauer, Peter M.; Wierks, Tamara G.; Podmore, Robin

    2009-04-01

    This report describes initial human factors evaluation of four visualization tools (Graphical Contingency Analysis, Force Directed Graphs, Phasor State Estimator and Mode Meter/ Mode Shapes) developed by PNNL, and proposed test plans that may be implemented to evaluate their utility in scenario-based experiments.

  8. Advisory Committee on human radiation experiments final report

    SciTech Connect (OSTI)

    1995-10-01

    When the Advisory Committee began work in April 1994 we were charged with determining whether the radiation experiments design and administration adequately met the ethical and scientific standards, including standards of informed consent, that prevailed at the time of the experiments and that exist today and also to determine the ethical and scientific standards and criteria by which it shall evaluate human radiation experiments. Although this charge seems straightforward, it is in fact difficult to determine what the appropriate standards should be for evaluating the conduct and policies of thirty or fifty years ago. First, we needed to determine the extent to which the standards of that time are similar to the standards of today. To the extent that there were differences we needed to determine the relative roles of each in making moral evaluations. In Chapter 1 we report what we have been able to reconstruct about government rules and policies in the 1940s and 1950s regarding human experiments. We focus primarily on the Atomic Energy Commission and the Department of Defense. In Chapter 2 we turn from a consideration of government standards to an exploration of the norms and practices of physicians and medical scientists who conducted research with human subjects during this period. Using the results of our Ethics Oral History Project, and other sources, we also examine how scientists of the time viewed their moral responsibilities to human subjects as well as how this translated into the manner in which they conducted their research.

  9. Statistical Analysis of Variation in the Human Plasma Proteome

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Corzett, Todd H.; Fodor, Imola K.; Choi, Megan W.; Walsworth, Vicki L.; Turteltaub, Kenneth W.; McCutchen-Maloney, Sandra L.; Chromy, Brett A.

    2010-01-01

    Quantifying the variation in the human plasma proteome is an essential prerequisite for disease-specific biomarker detection. We report here on the longitudinal and individual variation in human plasma characterized by two-dimensional difference gel electrophoresis (2-D DIGE) using plasma samples from eleven healthy subjects collected three times over a two week period. Fixed-effects modeling was used to remove dye and gel variability. Mixed-effects modeling was then used to quantitate the sources of proteomic variation. The subject-to-subject variation represented the largest variance component, while the time-within-subject variation was comparable to the experimental variation found in a previous technical variability study where onemore » human plasma sample was processed eight times in parallel and each was then analyzed by 2-D DIGE in triplicate. Here, 21 protein spots had larger than 50% CV, suggesting that these proteins may not be appropriate as biomarkers and should be carefully scrutinized in future studies. Seventy-eight protein spots showing differential protein levels between different individuals or individual collections were identified by mass spectrometry and further characterized using hierarchical clustering. The results present a first step toward understanding the complexity of longitudinal and individual variation in the human plasma proteome, and provide a baseline for improved biomarker discovery.« less

  10. Human genome program report. Part 2, 1996 research abstracts

    SciTech Connect (OSTI)

    1997-11-01

    This report contains Part 2 of a two-part report to reflect research and progress in the US Department of Energy Human Genome Program from 1994 through 1996, with specified updates made just before publication. Part 2 consists of 1996 research abstracts. Attention is focused on the following: sequencing; mapping; informatics; ethical, legal, and social issues; infrastructure; and small business innovation research.

  11. Framework for Human-Automation Collaboration: Conclusions from Four Studies

    SciTech Connect (OSTI)

    Johanna Oxstrand; Katya L. Le Blanc; John O'Hara; Jeffrey C. Joe; April M. Whaley; Heather Medema

    2013-11-01

    The Human Automation Collaboration (HAC) research project is investigating how advanced technologies that are planned for Advanced Small Modular Reactors (AdvSMR) will affect the performance and the reliability of the plant from a human factors and human performance perspective. The HAC research effort investigates the consequences of allocating functions between the operators and automated systems. More specifically, the research team is addressing how to best design the collaboration between the operators and the automated systems in a manner that has the greatest positive impact on overall plant performance and reliability. Oxstrand et al. (2013 - March) describes the efforts conducted by the researchers to identify the research needs for HAC. The research team reviewed the literature on HAC, developed a model of HAC, and identified gaps in the existing knowledge of human-automation collaboration. As described in Oxstrand et al. (2013 – June), the team then prioritized the research topics identified based on the specific needs in the context of AdvSMR. The prioritization was based on two sources of input: 1) The preliminary functions and tasks, and 2) The model of HAC. As a result, three analytical studies were planned and conduced; 1) Models of Teamwork, 2) Standardized HAC Performance Measurement Battery, and 3) Initiators and Triggering Conditions for Adaptive Automation. Additionally, one field study was also conducted at Idaho Falls Power.

  12. DOE Human Genome Program contractor-grantee workshop

    SciTech Connect (OSTI)

    1996-01-01

    This volume contains the proceedings for the DOE Human Genome Program`s Contractor-Grantee Workshop V held in Sante Fe, New Mexico January 28, February 1, 1996. Presentations were divided into sessions entitled Sequencing; Mapping; Informatics; Ethical, Legal, and Social Issues; and Infrastructure. Reports of individual projects described herein are separately indexed and abstracted for the database.

  13. T-547: Microsoft Windows Human Interface Device (HID) Vulnerability

    Broader source: Energy.gov [DOE]

    Microsoft Windows does not properly warn the user before enabling additional Human Interface Device (HID) functionality over USB, which allows user-assisted attackers to execute arbitrary programs via crafted USB data, as demonstrated by keyboard and mouse data sent by malware on a Smartphone that the user connected to the computer.

  14. Secondary structure of rat and human amylin across force fields

    SciTech Connect (OSTI)

    Hoffmann, Kyle Quynn; McGovern, Michael; Chiu, Chi -cheng; de Pablo, Juan J.; Paci, Emanuele

    2015-07-29

    The aggregation of human amylin has been strongly implicated in the progression of Type II diabetes. This 37-residue peptide forms a variety of secondary structures, including random coils, α-helices, and β-hairpins. The balance between these structures depends on the chemical environment, making amylin an ideal candidate to examine inherent biases in force fields. Rat amylin differs from human amylin by only 6 residues; however, it does not form fibrils. Therefore it provides a useful complement to human amylin in studies of the key events along the aggregation pathway. In this work, the free energy of rat and human amylin was determined as a function of α-helix and β-hairpin content for the Gromos96 53a6, OPLS-AA/L, CHARMM22/CMAP, CHARMM22*, Amberff99sb*-ILDN, and Amberff03w force fields using advanced sampling techniques, specifically bias exchange metadynamics. This work represents a first systematic attempt to evaluate the conformations and the corresponding free energy of a large, clinically relevant disordered peptide in solution across force fields. The NMR chemical shifts of rIAPP were calculated for each of the force fields using their respective free energy maps, allowing us to quantitatively assess their predictions. We show that the predicted distribution of secondary structures is sensitive to the choice of force-field: Gromos53a6 is biased towards β-hairpins, while CHARMM22/CMAP predicts structures that are overly α-helical. OPLS-AA/L favors disordered structures. Amberff99sb*-ILDN, AmberFF03w and CHARMM22* provide the balance between secondary structures that is most consistent with available experimental data. In contrast to previous reports, our findings suggest that the equilibrium conformations of human and rat amylin are remarkably similar, but that subtle differences arise in transient alpha-helical and beta-strand containing structures that the human peptide can more readily adopt. We hypothesize that these transient states enable

  15. Secondary structure of rat and human amylin across force fields

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hoffmann, Kyle Quynn; McGovern, Michael; Chiu, Chi -cheng; de Pablo, Juan J.; Paci, Emanuele

    2015-07-29

    The aggregation of human amylin has been strongly implicated in the progression of Type II diabetes. This 37-residue peptide forms a variety of secondary structures, including random coils, α-helices, and β-hairpins. The balance between these structures depends on the chemical environment, making amylin an ideal candidate to examine inherent biases in force fields. Rat amylin differs from human amylin by only 6 residues; however, it does not form fibrils. Therefore it provides a useful complement to human amylin in studies of the key events along the aggregation pathway. In this work, the free energy of rat and human amylin wasmore » determined as a function of α-helix and β-hairpin content for the Gromos96 53a6, OPLS-AA/L, CHARMM22/CMAP, CHARMM22*, Amberff99sb*-ILDN, and Amberff03w force fields using advanced sampling techniques, specifically bias exchange metadynamics. This work represents a first systematic attempt to evaluate the conformations and the corresponding free energy of a large, clinically relevant disordered peptide in solution across force fields. The NMR chemical shifts of rIAPP were calculated for each of the force fields using their respective free energy maps, allowing us to quantitatively assess their predictions. We show that the predicted distribution of secondary structures is sensitive to the choice of force-field: Gromos53a6 is biased towards β-hairpins, while CHARMM22/CMAP predicts structures that are overly α-helical. OPLS-AA/L favors disordered structures. Amberff99sb*-ILDN, AmberFF03w and CHARMM22* provide the balance between secondary structures that is most consistent with available experimental data. In contrast to previous reports, our findings suggest that the equilibrium conformations of human and rat amylin are remarkably similar, but that subtle differences arise in transient alpha-helical and beta-strand containing structures that the human peptide can more readily adopt. We hypothesize that these transient states

  16. A Human Factors Perspective on Alarm System Research and Development 2000 to 2010

    SciTech Connect (OSTI)

    Curt Braun; John Grimes; Eric Shaver; Ronald Boring

    2011-09-01

    By definition, alarms serve to notify human operators of out-of-parameter conditions that could threaten equipment, the environment, product quality and, of course, human life. Given the complexities of industrial systems, human machine interfaces, and the human operator, the understanding of how alarms and humans can best work together to prevent disaster is continually developing. This review examines advances in alarm research and development from 2000 to 2010 and includes the writings of trade professionals, engineering and human factors researchers, and standards organizations with the goal of documenting advances in alarms system design, research, and implementation.

  17. Human AZU-1 gene, variants thereof and expressed gene products

    DOE Patents [OSTI]

    Chen, Huei-Mei; Bissell, Mina

    2004-06-22

    A human AZU-1 gene, mutants, variants and fragments thereof. Protein products encoded by the AZU-1 gene and homologs encoded by the variants of AZU-1 gene acting as tumor suppressors or markers of malignancy progression and tumorigenicity reversion. Identification, isolation and characterization of AZU-1 and AZU-2 genes localized to a tumor suppressive locus at chromosome 10q26, highly expressed in nonmalignant and premalignant cells derived from a human breast tumor progression model. A recombinant full length protein sequences encoded by the AZU-1 gene and nucleotide sequences of AZU-1 and AZU-2 genes and variant and fragments thereof. Monoclonal or polyclonal antibodies specific to AZU-1, AZU-2 encoded protein and to AZU-1, or AZU-2 encoded protein homologs.

  18. Single-friction-surface triboelectric generator with human body conduit

    SciTech Connect (OSTI)

    Meng, Bo; Cheng, Xiaoliang; Zhang, Xiaosheng; Han, Mengdi; Liu, Wen; Zhang, Haixia

    2014-03-10

    We present a transparent single-friction-surface triboelectric generator (STEG) employing human body as the conduit, making the applications of STEG in portable electronics much more practical and leading to a significant output improvement. The STEG with micro-patterned polydimethylsiloxane surface achieved an output voltage of over 200 V with a current density of 4.7 ?A/cm{sup 2}. With human body conduit, the output current increased by 39% and the amount of charge that transferred increased by 34% compared to the results with grounded electrode. A larger increment of 210% and 81% was obtained in the case of STEG with a large-size flat polyethylene terephthalate surface.

  19. Measuring Human Performance within Computer Security Incident Response Teams

    SciTech Connect (OSTI)

    McClain, Jonathan T.; Silva, Austin Ray; Avina, Glory Emmanuel; Forsythe, James C.

    2015-09-01

    Human performance has become a pertinen t issue within cyber security. However, this research has been stymied by the limited availability of expert cyber security professionals. This is partly attributable to the ongoing workload faced by cyber security professionals, which is compound ed by the limited number of qualified personnel and turnover of p ersonnel across organizations. Additionally, it is difficult to conduct research, and particularly, openly published research, due to the sensitivity inherent to cyber ope rations at most orga nizations. As an alternative, the current research has focused on data collection during cyb er security training exercises. These events draw individuals with a range of knowledge and experience extending from seasoned professionals to recent college gradu ates to college students. The current paper describes research involving data collection at two separate cyber security exercises. This data collection involved multiple measures which included behavioral performance based on human - machine transactions and questionnaire - based assessments of cyber security experience.

  20. Issues in benchmarking human reliability analysis methods : a literature review.

    SciTech Connect (OSTI)

    Lois, Erasmia; Forester, John Alan; Tran, Tuan Q.; Hendrickson, Stacey M. Langfitt; Boring, Ronald L.

    2008-04-01

    There is a diversity of human reliability analysis (HRA) methods available for use in assessing human performance within probabilistic risk assessment (PRA). Due to the significant differences in the methods, including the scope, approach, and underlying models, there is a need for an empirical comparison investigating the validity and reliability of the methods. To accomplish this empirical comparison, a benchmarking study is currently underway that compares HRA methods with each other and against operator performance in simulator studies. In order to account for as many effects as possible in the construction of this benchmarking study, a literature review was conducted, reviewing past benchmarking studies in the areas of psychology and risk assessment. A number of lessons learned through these studies are presented in order to aid in the design of future HRA benchmarking endeavors.