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1

Outsmarting Flu Viruses | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

How Lead-Free Solder (Mis)Behaves under Stress How Lead-Free Solder (Mis)Behaves under Stress Dynamics of Polymer Chains Atop Different Materials Priming the Pump in the Fight against Drug-Resistant Tuberculosis The Ties that Bind Metals to Proteins A Novel Nanobio Catalyst for Biofuels Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Outsmarting Flu Viruses OCTOBER 9, 2012 Bookmark and Share Surface representation of influenza hemagglutinin (white) with the newly identified sites of vulnerability colored red. Each site is unique and targeted by a different antibody. CR8033 (blue) binds to the head of HA, CR8071 (green) just below the head, while CR9114 (yellow) binds the stem. The stem binding CR9114, with its cross-neutralizing ability for influenza

2

E-Print Network 3.0 - avian flu virus Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Ecology 15 prepared by the Pandemic Communications Committee Summary: or progressive cough Understand 12;What is avian flu? An illness caused by influenza viruses occurring...

3

Avian Flu  

SciTech Connect

Since 2003, a severe form of H5N1 avian influenza has rapidly spread throughout Asia and Europe, infecting over 200 humans in 10 countries. The spread of H5N1 virus from person-to-person has been rare, thus preventing the emergence of a widespread pandemic. However, this ongoing epidemic continues to pose an important public health threat. Avian flu and its pandemic potential in humans will be discussed.

Eckburg, Paul

2006-11-06T23:59:59.000Z

4

Flu Terms Defined  

NLE Websites -- All DOE Office Websites (Extended Search)

Flu Terms Defined Flu Terms Defined H1N1 Influenza is a respiratory disease of pigs caused by type A influenza viruses that causes regular outbreaks in pigs. People do not normally get H1N1 flu, but human infections can and do happen. H1N1 flu viruses have been reported to spread from person-to-person, but in the past, this transmission was limited and not sustained beyond three people. Avian flu (AI) is caused by influenza viruses that occur naturally among wild birds. Low pathogenic AI is common in birds and causes few problems. Highly pathogenic H5N1 is deadly to domestic fowl, can be transmitted from birds to humans, and is deadly to humans. There is virtually no human immunity and human vaccine availability is very limited. Pandemic flu is virulent human flu that causes a global outbreak, or pandemic, of serious illness. Because there is little natural immunity, the disease can spread easily from person to person. Currently, there is no pandemic flu.

5

E-Print Network 3.0 - avian flu update Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

is seasonal flu? Happens every year between November and March... or progressive cough Understand 12;What is avian flu? An illness caused by influenza viruses occurring...

6

E-Print Network 3.0 - attacks avian flu Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

is seasonal flu? Happens every year between November and March... or progressive cough Understand 12;What is avian flu? An illness caused by influenza viruses occurring...

7

NATURE|Vol 435|26 May 2005 AVIAN FLU COMMENTARY human flu pandemic could cause 20%  

E-Print Network (OSTI)

optimistic predictions of how the next flu pandemic might unfold. Like most emerging virus infections that threaten human health, flu outbreaks originate from animal reservoirs. Because of rapidly changing human with leading research groups from different disciplines. Close watch An outbreak of avian flu among chickens

Cai, Long

8

Toward Design of a Universal Flu Vaccine  

NLE Websites -- All DOE Office Websites (Extended Search)

Toward Design of a Universal Flu Vaccine Print Toward Design of a Universal Flu Vaccine Print Worldwide, influenza causes substantial deaths and yearly economic burdens, but the highly changeable nature of the flu virus complicates the production of an effective vaccine. The Centers for Disease Control and Prevention (CDC) estimates that the effectiveness of this year's flu vaccine is about 62%. For comparison, this number for childhood vaccines is routinely well over 90%. One factor in determining the vaccine's effectiveness is how closely related the viruses used in the vaccine are to the viruses circulating that year. An international team of researchers, working at synchrotron facilities including the ALS, has solved the crystal structures of antibodies that protect against broad classes of influenza strains. Greater understanding of these antibody structures may aid in the eventual development of a universal vaccine, protecting against all types of influenza viruses and thus eliminating the guesswork that currently limits vaccine effectiveness.

9

INFLUENZAVACCINE 2009 H1N1 influenza (also called Swine Flu) is caused  

E-Print Network (OSTI)

to seasonal flu viruses (their bod- ies have built up some ability to fight off the viruses). The 2009 H1N1 different from regular (seasonal) flu?2 Vaccines are available to protect against 2009 H1N1 influenza. · They will not prevent seasonal flu. You should also get seasonal influenza vaccine, if you want to be protected against

Suzuki, Masatsugu

10

Toward Design of a Universal Flu Vaccine  

NLE Websites -- All DOE Office Websites (Extended Search)

Toward Design of a Universal Flu Toward Design of a Universal Flu Vaccine Toward Design of a Universal Flu Vaccine Print Wednesday, 30 January 2013 00:00 Worldwide, influenza causes substantial deaths and yearly economic burdens, but the highly changeable nature of the flu virus complicates the production of an effective vaccine. The Centers for Disease Control and Prevention (CDC) estimates that the effectiveness of this year's flu vaccine is about 62%. For comparison, this number for childhood vaccines is routinely well over 90%. One factor in determining the vaccine's effectiveness is how closely related the viruses used in the vaccine are to the viruses circulating that year. An international team of researchers, working at synchrotron facilities including the ALS, has solved the crystal structures of antibodies that protect against broad classes of influenza strains. Greater understanding of these antibody structures may aid in the eventual development of a universal vaccine, protecting against all types of influenza viruses and thus eliminating the guesswork that currently limits vaccine effectiveness.

11

Everyday Preventive Actions That Can Help Fight Germs, Like Flu  

E-Print Network (OSTI)

spread? Flu viruses are thought to spread mainly from person to person through the coughing, sneezing and mouth with a tissuey when you cough or sneeze. This will block the spread of droplets from your mouth

Tipple, Brett

12

Inhibition of influenza A virus replication by influenza B virus nucleoprotein: An insight into interference between influenza A and B viruses  

SciTech Connect

Given that co-infection of cells with equivalent titers of influenza A and B viruses (FluA and FluB) has been shown to result in suppression of FluA growth, it is possible that FluB-specific proteins might hinder FluA polymerase activity and replication. We addressed this possibility by individually determining the effect of each gene of FluB on the FluA polymerase assay and found that the nucleoprotein of FluB (NP{sub FluB}) inhibits polymerase activity of FluA in a dose-dependent manner. Mutational analyses of NP{sub FluB} suggest that functional NP{sub FluB} is necessary for this inhibition. Slower growth of FluA was also observed in MDCK cells stably expressing NP{sub FluB}. Further analysis of NP{sub FluB} indicated that it does not affect nuclear import of NP{sub FluA}. Taken together, these findings suggest a novel role of NP{sub FluB} in inhibiting replication of FluA, providing more insights into the mechanism of interference between FluA and FluB and the lack of reassortants between them.

Wanitchang, Asawin; Narkpuk, Jaraspim; Jaru-ampornpan, Peera; Jengarn, Juggagarn [Virology and Cell Technology Laboratory, National Center for Genetic Engineering and Biotechnology (BIOTEC), Pathumthani 12120 (Thailand)] [Virology and Cell Technology Laboratory, National Center for Genetic Engineering and Biotechnology (BIOTEC), Pathumthani 12120 (Thailand); Jongkaewwattana, Anan, E-mail: anan.jon@biotec.or.th [Virology and Cell Technology Laboratory, National Center for Genetic Engineering and Biotechnology (BIOTEC), Pathumthani 12120 (Thailand)] [Virology and Cell Technology Laboratory, National Center for Genetic Engineering and Biotechnology (BIOTEC), Pathumthani 12120 (Thailand)

2012-10-10T23:59:59.000Z

13

Structure and Receptor Specificity of an Avian Flu Antigen  

NLE Websites -- All DOE Office Websites (Extended Search)

Structure and Receptor Structure and Receptor Specificity of an Avian Flu Antigen Structure and Receptor Specificity of an Avian Flu Antigen Print Wednesday, 25 July 2007 00:00 To date, the H5N1 avian influenza viruses, which are currently circulating in domestic and wild birds on three continents, have only a limited ability to infect humans. However, with continued outbreaks of the virus in poultry and wild birds, the potential for the emergence of a human-adapted H5 virus, either by reassortment (the mixing of genetic material from similar viruses) or mutation, is seen as a major threat to public health worldwide. Of the three influenza pandemics of the last century, the 1957 (H2N2) and 1968 (H3N2) pandemics involved avian-human reassortments. The origin of the 1918 influenza virus (H1N1), which killed about 50 million people worldwide, is unknown. Although a number of viral factors can determine the host range restriction and pathogenicity of influenza A viruses, recent evidence suggests that hemagglutinin (HA), the principal antigen on the viral surface, is a critical factor for efficient human-to-human transmission. Researchers have now solved the HA structure to 2.9 Å at the ALS and analyzed its specificity to human receptors.

14

Structure and Receptor Specificity of an Avian Flu Antigen  

NLE Websites -- All DOE Office Websites (Extended Search)

Structure and Receptor Specificity of an Avian Flu Antigen Print Structure and Receptor Specificity of an Avian Flu Antigen Print To date, the H5N1 avian influenza viruses, which are currently circulating in domestic and wild birds on three continents, have only a limited ability to infect humans. However, with continued outbreaks of the virus in poultry and wild birds, the potential for the emergence of a human-adapted H5 virus, either by reassortment (the mixing of genetic material from similar viruses) or mutation, is seen as a major threat to public health worldwide. Of the three influenza pandemics of the last century, the 1957 (H2N2) and 1968 (H3N2) pandemics involved avian-human reassortments. The origin of the 1918 influenza virus (H1N1), which killed about 50 million people worldwide, is unknown. Although a number of viral factors can determine the host range restriction and pathogenicity of influenza A viruses, recent evidence suggests that hemagglutinin (HA), the principal antigen on the viral surface, is a critical factor for efficient human-to-human transmission. Researchers have now solved the HA structure to 2.9 Å at the ALS and analyzed its specificity to human receptors.

15

Structure and Receptor Specificity of an Avian Flu Antigen  

NLE Websites -- All DOE Office Websites (Extended Search)

Structure and Receptor Specificity of an Avian Flu Antigen Print Structure and Receptor Specificity of an Avian Flu Antigen Print To date, the H5N1 avian influenza viruses, which are currently circulating in domestic and wild birds on three continents, have only a limited ability to infect humans. However, with continued outbreaks of the virus in poultry and wild birds, the potential for the emergence of a human-adapted H5 virus, either by reassortment (the mixing of genetic material from similar viruses) or mutation, is seen as a major threat to public health worldwide. Of the three influenza pandemics of the last century, the 1957 (H2N2) and 1968 (H3N2) pandemics involved avian-human reassortments. The origin of the 1918 influenza virus (H1N1), which killed about 50 million people worldwide, is unknown. Although a number of viral factors can determine the host range restriction and pathogenicity of influenza A viruses, recent evidence suggests that hemagglutinin (HA), the principal antigen on the viral surface, is a critical factor for efficient human-to-human transmission. Researchers have now solved the HA structure to 2.9 Å at the ALS and analyzed its specificity to human receptors.

16

Swine Influenza (swine flu) Fact Sheet What is swine flu?  

E-Print Network (OSTI)

that the child does not want to be held · Flu-like symptoms improve but then return with fever and worse cough your health: #12;· Cover your nose and mouth with a tissue when you cough or sneeze. Throw the tissue in the trash after you use it. · Wash your hands often with soap and water, especially after you cough

Olsen, Stephen L.

17

Battling bird flu by the numbers  

NLE Websites -- All DOE Office Websites (Extended Search)

bird flu by the numbers Lab theorists have developed a mathematical tool that could help health experts and crisis managers determine in real time whether an emerging...

18

Modeling the spread of bird flu and predicting outbreak diversity  

Science Journals Connector (OSTI)

Avian influenza, commonly known as bird flu, is an epidemic caused by H5N1 virus that primarily affects birds like chickens, wild water birds, etc. On rare occasions, these can infect other species including pigs and humans. In the span of less than a year, the lethal strain of bird flu is spreading very fast across the globe mainly in South East Asia, parts of Central Asia, Africa and Europe. In order to study the patterns of spread of epidemic, we made an investigation of outbreaks of the epidemic in one week, that is from February 1318, 2006, when the deadly virus surfaced in India. We have designed a statistical transmission model of bird flu taking into account the factors that affect the epidemic transmission such as source of infection, social and natural factors and various control measures are suggested. For modeling the general intensity coefficient f ( r ) , we have implemented the recent ideas given in the article Fitting the Bill, Nature [R. Howlett, Fitting the bill, Nature 439 (2006) 402], which describes the geographical spread of epidemics due to transportation of poultry products. Our aim is to study the spread of avian influenza, both in time and space, to gain a better understanding of transmission mechanism. Our model yields satisfactory results as evidenced by the simulations and may be used for the prediction of future situations of epidemic for longer periods. We utilize real data at these various scales and our model allows one to generalize our predictions and make better suggestions for the control of this epidemic.

Ranjit Kumar Upadhyay; Nitu Kumari; V. Sree Hari Rao

2008-01-01T23:59:59.000Z

19

Novel Materials Become Multifunctional at the Ultimate Quantum Limit |  

NLE Websites -- All DOE Office Websites (Extended Search)

Outsmarting Flu Viruses Outsmarting Flu Viruses How Lead-Free Solder (Mis)Behaves under Stress Dynamics of Polymer Chains Atop Different Materials Priming the Pump in the Fight against Drug-Resistant Tuberculosis The Ties that Bind Metals to Proteins Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Novel Materials Become Multifunctional at the Ultimate Quantum Limit NOVEMBER 9, 2012 Bookmark and Share Illustration of a 4-unit-cell film of NdNiO3 (white) confined by LaAlO3 (blue) at the boundaries to make a quantum well structure. Our computers carry out their functions on several semiconducting devices layered together in the very smallest of spaces, known as quantum wells,

20

Transmissibility of swine flu at Fort Dix, 1976  

Science Journals Connector (OSTI)

...1976 swine flu, including...important model assumptions...The 1976 outbreak of A/New...Computational models predict that it may...1976 swine flu, including...of swine flu at Fort Dix...The 1976 outbreak of A/New...Computational models predict that it may...

2007-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Pandemic Flu: What To Know and  

E-Print Network (OSTI)

cough or sneeze Throw the tissue in the trash after you use it Ifor sneeze. Throw the tissue in the trash after you use it. If a tissue is unavailable, cough or sneeze into your shoulder or elbow instead sick children at home. ­ If you have flu-like symptoms (fever with cough or sore throat), stay home

Tipple, Brett

22

INFLUENZA 101 Symptoms of the flu  

E-Print Network (OSTI)

INFLUENZA 101 Symptoms of the flu Sudden onset of fever/chills, coughing, muscle aches, headache · Stay home and limit contact with others until coughing and/or sneezing subside (usually · If having difficulty breathing doing ordinary things, or are coughing up blood · If not improving by the end

Abolmaesumi, Purang

23

FLU ALERT SYMPTOMS AND TREATMENT Spring 2014  

E-Print Network (OSTI)

: Dry Cough Nasal Congestion Sore Throat THE BEST TREATMENT FOR THE FLU IS ­ Rest! Cough syrup if coughing interferes with sleep You are most contagious from the day before your symptoms begin, through the period of prominent symptoms. Symptoms usually last a week, but coughing can persist

Rhode Island, University of

24

Broad Protection against Avian Influenza Virus by Using a Modified Vaccinia Ankara Virus Expressing a Mosaic Hemagglutinin Gene  

Science Journals Connector (OSTI)

...influenza viruses poses global health challenges necessitating...pandemics. Bull. World Health Organ. 82 :242. 3...bird flu'? J. Child Health Care 10 :178-187. doi...provide opportunities for reform in influenza vaccine design...

Attapon Kamlangdee; Brock Kingstad-Bakke; Tavis K. Anderson; Tony L. Goldberg; Jorge E. Osorio

2014-09-10T23:59:59.000Z

25

Battling bird flu by the numbers  

NLE Websites -- All DOE Office Websites (Extended Search)

May » May » Battling bird flu by the numbers Battling bird flu by the numbers Lab theorists have developed a mathematical tool that could help health experts and crisis managers determine in real time whether an emerging infectious disease such as avian influenza H5N1 is poised to spread globally. May 27, 2008 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy

26

PREPARE NOW TO BEAT THE FLU! (2010-2011) GET THE FLU VACCINE AS SOON AS POSSIBLE,  

E-Print Network (OSTI)

is ok) 5. Cough syrup (similar to Robitussin DM, generic is ok) 6. Tissues Students can purchase a "Flu, hand sanitizer, acetaminophen, cough syrup, and throat lozenges. You may also purchase the items above, cough, sore throat, and body aches. · Most individuals who get the flu who do not have a high risk

Saldin, Dilano

27

E-Print Network 3.0 - aleutian disease virus Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

45 EXCELLENTIA CoLumbIA ENgINEErINg70 ach year as many as one in five Americans get the flu. More than 200,000 end Summary: viruses invade cells so they can help develop...

28

Detection of Mammalian Virulence Determinants in Highly Pathogenic Avian Influenza H5N1 Viruses: Multivariate Analysis of Published Data  

Science Journals Connector (OSTI)

...Kong 1997 outbreak isolates...statistical model to describe...the NCBI Flu database...Hence, the model and wider...Hong Kong outbreak has reemerged...2005. Avian flu H5N1 virus outbreak in migratory...graphical models. Science...

S. J. Lycett; M. J. Ward; F. I. Lewis; A. F. Y. Poon; S. L. Kosakovsky Pond; A. J. Leigh Brown

2009-07-22T23:59:59.000Z

29

Cold and Flu Prevention - HPMC Occupational Health Services  

NLE Websites -- All DOE Office Websites (Extended Search)

Awareness Cold and Flu Prevention Hand Washing Healthy Sleep Heat Stress Radon Signs of a Heart Attack Signs of a Stroke Distracted Driving Coping with Stress & Change Skin Cancer...

30

Modeling the Spread and Outbreak Dynamics of Avian Influenza (H5N1) Virus and Its Possible Control  

Science Journals Connector (OSTI)

Avian Influenza, commonly known as Bird Flu, is an epidemic caused by H5N1 Virus ... The present chapter is aimed at developing mathematical models that predict the spread and outbreak diversity of low pathogenic...

V. Sree Hari Rao; Ranjit Kumar Upadhyay

2013-01-01T23:59:59.000Z

31

Dear CSU students, faculty and staff, There has been a lot of attention recently paid to the severity of this flu season and the importance of  

E-Print Network (OSTI)

OF YOURSELF OR SOMEONE ELSE WITH THE FLU: Flu symptoms are fever, cough, sore throat, runny or stuffy nose

Stephens, Graeme L.

32

Fast pandemic detection tool ready to fight flu  

NLE Websites -- All DOE Office Websites (Extended Search)

Fast pandemic detection tool ready to fight flu Fast pandemic detection tool ready to fight flu Fast pandemic detection tool ready to fight flu Researchers are developing new tools for rapidly characterizing biological pathogens that could give rise to potentially deadly pandemics such as Influenza A (H1N1). June 9, 2009 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials.

33

Using Google Flu Trends data in forecasting influenza-likeillness related ED visits in Omaha, Nebraska  

Science Journals Connector (OSTI)

AbstractIntroduction Emergency department (ED) visits increase during the influenza seasons. It is essential to identify statistically significant correlates in order to develop an accurate forecasting model for ED visits. Forecasting influenza-likeillness (ILI)-related ED visits can significantly help in developing robust resource management strategies at the EDs. Methods We first performed correlation analyses to understand temporal correlations between several predictors of ILI-related ED visits. We used the data available for Douglas County, the biggest county in Nebraska, for Omaha, the biggest city in the state, and for a major hospital in Omaha. The data set included total and positive influenza test results from the hospital (ie, Antigen rapid (Ag) and Respiratory Syncytial Virus Infection (RSV) tests); an Internet-based influenza surveillance system data, that is, Google Flu Trends, for both Nebraska and Omaha; total ED visits in Douglas County attributable to ILI; and ILI surveillance network data for Douglas County and Nebraska as the predictors and data for the hospital's ILI-related ED visits as the dependent variable. We used Seasonal Autoregressive Integrated Moving Average and Holt Winters methods with3 linear regression models to forecast ILI-related ED visits at the hospital and evaluated model performances by comparing the root means square errors (RMSEs). Results Because of strong positive correlations with ILI-related ED visits between 2008 and 2012, we validated the use of Google Flu Trends data as a predictor in an ED influenza surveillance tool. Of the 5 forecasting models we have tested, linear regression models performed significantly better when Google Flu Trends data were included as a predictor. Regression models including Google Flu Trends data as a predictor variable have lower RMSE, and the lowest is achieved when all other variables are also included in the model in our forecasting experiments for the first 5 weeks of 2013 (with RMSE = 57.61). Conclusions Google Flu Trends data statistically improve the performance of predicting ILI-related ED visits in Douglas County, and this result can be generalized to other communities. Timely and accurate estimates of ED volume during the influenza season, as well as during pandemic outbreaks, can help hospitals plan their ED resources accordingly and lower their costs by optimizing supplies and staffing and can improve service quality by decreasing ED wait times and overcrowding.

Ozgur M. Araz; Dan Bentley; Robert L. Muelleman

2014-01-01T23:59:59.000Z

34

Foiling the Flu Bug Global Partnerships for Nuclear Energy  

E-Print Network (OSTI)

1 1663 Foiling the Flu Bug Global Partnerships for Nuclear Energy Dark Universe Mysteries WILL NOT NEED TESTING Expanding Nuclear Energy the Right Way GLOBAL PARTNERSHIPS AND AN ADVANCED FUEL CYCLE sense.The Laboratory is operated by Los Alamos National Security, LLC, for the Department of Energy

35

Universal Detection and Identification of Avian Influenza Virus by Use of Resequencing Microarrays  

Science Journals Connector (OSTI)

...identifying the spread or outbreak of all variants of avian...infections in humans. Recent outbreaks of Nipah virus, severe...25). Recent major outbreaks in domestic poultry and...that contribute to or predict influenza virus pathogenicity...microarray (TessArray RPM-Flu 3.0 and 3.1, subsequently...

Baochuan Lin; Anthony P. Malanoski; Zheng Wang; Kate M. Blaney; Nina C. Long; Carolyn E. Meador; David Metzgar; Christopher A. Myers; Samuel L. Yingst; Marshall R. Monteville; Magdi D. Saad; Joel M. Schnur; Clark Tibbetts; David A. Stenger

2009-03-11T23:59:59.000Z

36

E-Print Network 3.0 - avian flu vaccine Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

is seasonal flu? Happens every year between November and March... or progressive cough Understand ... Source: Stowell, Michael - Department of Molecular, Cellular, and...

37

H7N9 and Other Pathogenic Avian Influenza Viruses Elicit a Three-Pronged Transcriptomic Signature That Is Reminiscent of 1918 Influenza Virus and Is Associated with Lethal Outcome in Mice  

Science Journals Connector (OSTI)

...H7N9 influenza. To predict potential antivirals...H5N1 virus in that model (33). This difference...different experimental models. Dobutamine is a...function in a rat lung model of hypothermia and...beings during a large outbreak in commercial poultry...www.cdc.gov/flu/avianflu/h7n9-virus...

Juliet Morrison; Laurence Josset; Nicolas Tchitchek; Jean Chang; Jessica A. Belser; David E. Swayne; Mary J. Pantin-Jackwood; Terrence M. Tumpey; Michael G. Katze

2014-07-02T23:59:59.000Z

38

The relationship between obsessive compulsive beliefs and symptoms, anxiety and disgust sensitivity, and Swine Flu fears  

Science Journals Connector (OSTI)

Using the 2009 Swine Flu outbreak as a contemporary example of pandemic fears, this study examined the relationship between various symptoms related to anxiety sensitivity and Swine Flu fears. It was hypothesized that both obsessivecompulsive (OC) beliefs and OC symptoms would significantly predict Swine Flu fears. It was also hypothesized that symptoms of anxiety, including measures of anxiety sensitivity and disgust sensitivity would significantly mediate the relationship between both OC beliefs and OC symptoms and Swine Flu fears. A total of 393 undergraduate students completed measures of Swine Flu fears, anxiety sensitivity, OC beliefs and symptoms, and disgust sensitivity. It was found that both OC beliefs and OC symptoms significantly predicted Swine Flu fears. While disgust sensitivity significantly mediated the relationship between both OC beliefs and OC symptoms and Swine Flu fears using the Sobel test, anxiety sensitivity was a significant mediator only for OC symptoms. Additionally, path modeling showed that anxiety sensitivity mediated the relationship between OC symptoms and Swine Flu fears best. The results of this study may be useful for treating individuals suffering from anxiety in light of future pandemics, as well as continuing to research the role of anxiety symptoms in predicting pandemic fears.

Joseph Brand; Dean McKay; Michael G. Wheaton; Jonathan S. Abramowitz

2013-01-01T23:59:59.000Z

39

Research priorities in modeling the transmission risks of H7N9 bird flu  

Science Journals Connector (OSTI)

As a new emerging infection, good system for surveillance and prediction of H7N9 bird flu outbreak is very important. Research priorities in modeling the transmission risks of H7N9 bird flu include many mulitdisciplinary approaches and international collaboration. Image: H7N9 migration from bird genetic mutation to human outbreak.

Viroj Wiwanitkit; Benyun Shi; Shang Xia; Guo-Jing Yang; Xiao-Nong Zhou; Jiming Liu

2013-08-08T23:59:59.000Z

40

Naturally Occurring Swine Influenza A Virus PB1-F2 Phenotypes That Contribute to Superinfection with Gram-Positive Respiratory Pathogens  

Science Journals Connector (OSTI)

...be monitored to predict the severity of...virus infection models alone may not...Butler, D . 2012. Flu surveillance lacking...characterization of a mouse model and the role of...seasonal influenza outbreak 2010/11 in South...viruses in the mouse model is increased by...relation to influenza outbreaks, 2006-2010...

Jenni N. Weeks-Gorospe; Heather R. Hurtig; Amy R. Iverson; Margaret J. Schuneman; Richard J. Webby; Jonathan A. McCullers; Victor C. Huber

2012-06-06T23:59:59.000Z

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

A Unique and Conserved Neutralization Epitope in H5N1 Influenza Viruses Identified by an Antibody against the A/Goose/Guangdong/1/96 Hemagglutinin  

Science Journals Connector (OSTI)

...H5N1 virus, it is difficult to predict the major strain that might...antibody H5M9 in a mouse infection model indicated that H5M9 is able...of H5N1 viruses from the 1997 outbreaks in Hong Kong. Virology 261...and Y Kawaoka. 2005. Avian flu: isolation of drug-resistant...

Xueyong Zhu; Yong-Hui Guo; Tao Jiang; Ya-Di Wang; Kwok-Hung Chan; Xiao-Feng Li; Wenli Yu; Ryan McBride; James C. Paulson; Kwok-Yung Yuen; Cheng-Feng Qin; Xiao-Yan Che; Ian A. Wilson

2013-09-18T23:59:59.000Z

42

Identification of cardioviruses related to Theiler's murine encephalomyelitis virus in human infections  

Science Journals Connector (OSTI)

...exclude cases of RSV, Flu A/B...cluster analysis, E-Predict, and z score analysis as...virus infection: A model for multiple sclerosis . Clin Microbiol...Urisman A ( 2005 ) E-Predict: A computational strategy...2007 ) Creating a model program for influenza surveillance...2005 ) Rhinovirus outbreak in a long term care...

Charles Y. Chiu; Alexander L. Greninger; Kimberly Kanada; Thomas Kwok; Kael F. Fischer; Charles Runckel; Janice K. Louie; Carol A. Glaser; Shigeo Yagi; David P. Schnurr; Tom D. Haggerty; Julie Parsonnet; Don Ganem; Joseph L. DeRisi

2008-01-01T23:59:59.000Z

43

Understanding social amplification of risk : possible impact of an avian flu pandemic  

E-Print Network (OSTI)

Today, stakeholders expect organizations to be able to endure external shocks. Hence, the real potential of an avian flu pandemic has many corporations developing business continuity plans for the disruptions that a pandemic ...

Sundrani, Aamir (Aamir Sultan)

2007-01-01T23:59:59.000Z

44

Students experiencing flu-like symptoms, such as fever with cough and/or sore throat,  

E-Print Network (OSTI)

Students experiencing flu-like symptoms, such as fever with cough and/or sore throat, should other difficulty breathing beyond a typical cough. Inform Undergraduates: Notify the director

Bou-Zeid, Elie

45

NATURE BIOTECHNOLOGY VOLUME 24 NUMBER 2 FEBRUARY 2006 139 A DNA flu vaccine in practice  

E-Print Network (OSTI)

NATURE BIOTECHNOLOGY VOLUME 24 NUMBER 2 FEBRUARY 2006 139 A DNA flu vaccine in practice in Biotechnology Progress (21, 1577­1592, 2005) and suggest that though challenging, it should be possible. However

Church, George M.

46

City of Chicago won't sweat the flu with Argonne's help | Argonne...  

NLE Websites -- All DOE Office Websites (Extended Search)

City of Chicago won't sweat the flu with Argonne's help By Louise Lerner * September 7, 2011 Tweet EmailPrint This spring, officials at Chicago's Department of Public Health (CPDH)...

47

Comparative Study of Influenza Virus Replication in MDCK Cells and in Primary Cells Derived from Adenoids and Airway Epithelium  

Science Journals Connector (OSTI)

...and NHBE cells, for their ability to model the levels of restriction of ca influenza...43. Shinya, K , et al. 2006. Avian flu: influenza virus receptors in the human...despite the fact that all tissue culture models lack a functional adaptive immune system...

Natalia A. Ilyushina; Mine R. Ikizler; Yoshihiro Kawaoka; Larisa G. Rudenko; John J. Treanor; Kanta Subbarao; Peter F. Wright

2012-08-22T23:59:59.000Z

48

What can you do to stop the flu? Cover your cough! Help stop the spread of germs by  

E-Print Network (OSTI)

What can you do to stop the flu? · Cover your cough! Help stop the spread of germs by covering your mouth and nose when you cough or sneeze with a tissue or with your upper sleeve. · Wash your hands surfaces. · Flu symptoms include: - Fever - Extreme tiredness - Headache - Cough - Muscle aches - Runny

Burke, Peter

49

Forecasting the belief of the population: Prediction Markets, Social Media & Swine Flu  

E-Print Network (OSTI)

Forecasting the belief of the population: Prediction Markets, Social Media & Swine Flu Daniel outbreak as a novel example to evaluate our models on the belief that it would turn into a pandemic. We and slow to run. Recently prediction markets have become a popular method to aggregate information

Hammerton, James

50

Predicting the anticipated emotional and behavioral responses to an avian flu outbreak  

Science Journals Connector (OSTI)

Background The purpose of this study was to develop a model to predict the emotional and behavioral responses to an avian flu outbreak. Methods The participants were 289 university students ranging in age, income, and ethnic backgrounds. They were presented with scenarios describing avian flu outbreaks affecting their community. They reported their anticipated emotional responses (positive emotion, negative emotion) and behavioral responses (helping, avoidance, sacrifice, illegal behavior) as if the scenarios were actually occurring. They also were assessed on individual differences expected to predict their responses. Results Participants were only modestly familiar with the avian flu and anticipated strong emotional and behavioral responses to an outbreak. Path analyses were conducted to test a model for predicting responses. The model showed that age, sex, income, spirituality, resilience, and neuroticism were related to responses. Spirituality, resilience, and income predicted better emotional responses, and neuroticism and female sex predicted worse emotional responses. Age, sex, income, and spirituality had direct effects on behavior. The emotional responses were directly related to each behavior and mediated the effects of individual differences. Conclusion Emotional responses may be important in predicting behavior after an outbreak of avian flu, and personal characteristics may predict both emotional and behavioral responses.

Bruce W. Smith; Virginia S. Kay; Timothy V. Hoyt; Michael L. Bernard

2009-01-01T23:59:59.000Z

51

NATURE|Vol 435|26 May 2005 AVIAN FLU COMMENTARY IsChinapreparedformicrobialthreats?  

E-Print Network (OSTI)

NATURE|Vol 435|26 May 2005 AVIAN FLU COMMENTARY 421 Is. S evere acute respiratory syndrome (SARS) was unquestionably a loud wake- up call for China. The outbreak with the transparency that the crisis required. A chance to nip the outbreak in the bud was lost, and the consequences

Cai, Long

52

Worried about H1N1 SWINE FLU? What you should do.  

E-Print Network (OSTI)

with severe illness like difficulty breathing AND YOU HAVE Fever (100.4) plus cough or sore throat Fever (100.4) plus cough or sore throat Fever (100.4) plus cough or sore throat YOU SHOULD Stay home until you fever, cough, sore throat, tiredness, aches, chills and stuffy nose. H1N1 flu spreads when a sick person

Tipple, Brett

53

PREPARE NOW TO BEAT THE FLU! Updated for 2012-2013 Influenza Season  

E-Print Network (OSTI)

is ok) 5. Cough syrup (similar to Robitussin DM, generic is ok) 6. Tissues 7. Contact numbers: Primary sanitizer, acetaminophen, cough syrup, and throat lozenges. These are also located at the Sandburg Emporium include: Fever over 100 degrees F, cough, sore throat, and body aches. · Most individuals who get the flu

Saldin, Dilano

54

Worried about H1N1 SWINE FLU? What you should do.  

E-Print Network (OSTI)

with severe illness like difficulty breathing AND YOU HAVE Fever (100.4) plus cough or sore throat Fever (100.4) plus cough or sore throat Fever (100.4) plus cough or sore throat YOU SHOULD Stay home until you. The illness can cause fever, cough, sore throat, tiredness, aches, chills and stuffy nose. H1N1 flu spreads

Brinkmann, Peter

55

Real-Time Disease Surveillance Using Twitter Data: Demonstration on Flu and Cancer  

E-Print Network (OSTI)

, and text mining. The real-time analysis data is visually re- ported as U.S. disease activity map, timelinesReal-Time Disease Surveillance Using Twitter Data: Demonstration on Flu and Cancer Kathy Lee Ankit-effects, and so on. This makes publicly available social media data an invaluable resource for mining interesting

56

Cover your Cough! Quantifying the Benefits of a Localized Healthy Behavior Intervention on Flu  

E-Print Network (OSTI)

Cover your Cough! Quantifying the Benefits of a Localized Healthy Behavior Intervention on Flu a policy that encourages healthy behaviors (such as covering your cough and using hand sanitizers) at four coughs, minimizing contact with potential fomites) at major tourist locations. We use a synthetic

Swarup, Samarth

57

What are the symptoms of flu? Symptoms include sudden onset of  

E-Print Network (OSTI)

What are the symptoms of flu? · Symptoms include sudden onset of: o fever/chills o cough o muscle lasting 5 or more days (measured with a thermometer; 37.0 Celsius is normal) · Coughing up blood that improve but then return with fever and worse cough Those in high risk groups including pregnant women

Ellis, Randy

58

RNA Folding: A Little Cooperation Goes a Long Way | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

A New Phase in Cellular Communication A New Phase in Cellular Communication Engineering Thin-Film Oxide Interfaces Novel Materials Become Multifunctional at the Ultimate Quantum Limit Outsmarting Flu Viruses How Lead-Free Solder (Mis)Behaves under Stress Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed RNA Folding: A Little Cooperation Goes a Long Way NOVEMBER 19, 2012 Bookmark and Share Shown here is the energy landscape for folding of a ribozyme, and how cooperation between tertiary interactions at different parts of the structure (red dots) help the RNA reach its unique native structure and avoid non-native intermediates. The nucleic acid RNA is an essential part of the critical process by which

59

Engineering Thin-Film Oxide Interfaces | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

Novel Materials Become Multifunctional at the Ultimate Quantum Limit Novel Materials Become Multifunctional at the Ultimate Quantum Limit Outsmarting Flu Viruses How Lead-Free Solder (Mis)Behaves under Stress Dynamics of Polymer Chains Atop Different Materials Priming the Pump in the Fight against Drug-Resistant Tuberculosis Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Engineering Thin-Film Oxide Interfaces NOVEMBER 12, 2012 Bookmark and Share LAO thin films on STO substrates are depicted in the top schematics (LAO indicated by blue spheres, STO by green spheres). The top left-hand panel demonstrates a chemically broad interface resulting from conventional growth in a low pressure oxygen environment. In contrast, the top

60

A New Phase in Cellular Communication | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

Engineering Thin-Film Oxide Interfaces Engineering Thin-Film Oxide Interfaces Novel Materials Become Multifunctional at the Ultimate Quantum Limit Outsmarting Flu Viruses How Lead-Free Solder (Mis)Behaves under Stress Dynamics of Polymer Chains Atop Different Materials Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A New Phase in Cellular Communication NOVEMBER 15, 2012 Bookmark and Share Interactions between N-WASP, phospho-Nephrin and Nck produce large polymers (top panel) that phase separate to produce liquid droplets suspended in aqueous solution (bottom panel). In many physical processes, substances undergo phase transitions, where they are transformed from one state (solid, liquid, or gas) to another.

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

E-Print Network 3.0 - african swine fever virus Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

Flu" (H1N1 Influenza) Similarities to seasonal flu H1N1 flu symptoms - Fever, cough, muscle... Swine Flu and Common Infections to Prepare For Rochester ... Source:...

62

Chasing a common cold virus | Argonne National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

Robert Fischetti (left), Glen Nemerow (center) and Vijay Reddy load samples at the Advanced Photon Source. Robert Fischetti (left), Glen Nemerow (center) and Vijay Reddy load samples at the Advanced Photon Source. Robert Fischetti (left), Glen Nemerow (center) and Vijay Reddy load samples at the Advanced Photon Source. Chasing a common cold virus By Susheela Bhat * October 19, 2012 Tweet EmailPrint As the cold and flu season makes its annual visit, a team of researchers, using Argonne's Advanced Photon Source, continue to complete a detailed map of the human adenovirus-one of several viruses responsible for the common cold. Although human adenovirus is usually not deadly, it is a seasonal nuisance to some and can cause deadly infections in others. In the early 1990s, Glen Nemerow, professor and principal investigator at the Immunology and Microbial Science division of The Scripps Institute,

63

Performance of the Molecular Alere i Influenza A&B Test Compared to Xpert Flu A/B Assay  

Science Journals Connector (OSTI)

...American Society for Microbiology. All Rights Reserved. 2014 research-article Performance of the Molecular Alere i Influenza AB Test Compared to Xpert Flu A/B Assay Kimberle C. Chapin 1 2 * Estefany J. Flores-Cortez 1 * Corresponding author: Lifespan...

Kimberle C. Chapin; Estefany J. Flores-Cortez

2014-12-10T23:59:59.000Z

64

Newly Described "Dragon" Protein Could Be Key to Bird Flu Cure |  

NLE Websites -- All DOE Office Websites (Extended Search)

Hearing the Highest Pitches Hearing the Highest Pitches Unveiling the Secrets of Nanoparticle Haloing A Fruit-Fly Protein that Captures Tumor Growth Factors A Protein that Repairs Damage to Cancer Cells An X-ray Vortex on the Horizon? Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed Newly Described "Dragon" Protein Could Be Key to Bird Flu Cure JULY 16, 2008 Bookmark and Share The overall structure of the PAC -PB1 N complex. The structure is colored according to secondary structure and elements are labeled. Helices are shown as cylinders and are red in the brain domain and blue in the mouth domain; strands are yellow and loops are green. The PB1 N peptide is

65

Nowcasting economic and social data: when and why search engine data fails, an illustration using Google Flu Trends  

E-Print Network (OSTI)

Obtaining an accurate picture of the current state of the economy is particularly important to central banks and finance ministries, and of epidemics to health ministries. There is increasing interest in the use of search engine data to provide such 'nowcasts' of social and economic indicators. However, people may search for a phrase because they independently want the information, or they may search simply because many others are searching for it. We consider the effect of the motivation for searching on the accuracy of forecasts made using search engine data of contemporaneous social and economic indicators. We illustrate the implications for forecasting accuracy using four episodes in which Google Flu Trends data gave accurate predictions of actual flu cases, and four in which the search data over-predicted considerably. Using a standard statistical methodology, the Bass diffusion model, we show that the independent search for information motive was much stronger in the cases of accurate prediction than in...

Ormerod, Paul; Bentley, R Alexander

2014-01-01T23:59:59.000Z

66

The Centers for Disease Control and Prevention (CDC) urges you to take the following steps to protect yourself and others from influenza (the flu)  

E-Print Network (OSTI)

, cough, sore throat, runny or stuffy nose, body aches, headache, chills and fatigue. Some people may also://WWW.FLU.GOV or call 800-CDC-INFO ·Cover your nose and mouth with a tissue when you cough or sneeze. Throw the tissue-LIKE SYMPTOMS INCLUDE: fever cough sorethroat runnyorstuffynose bodyaches headache chills fatigue Some people

Tipple, Brett

67

West Nile Virus  

NLE Websites -- All DOE Office Websites (Extended Search)

NILE VIRUS (WNS) NILE VIRUS (WNS) DEFINITION West Nile virus is an infection transmitted by mosquitoes. If you become infected with West Nile virus, you may not experience any signs or symptoms or you may experience only minor ones, such as fever and mild headache. However, some people who become infected with West Nile virus develop a life-threatening illness that includes inflammation of the brain. MODES OF TRANSMISSION The main route of human infection with West Nile virus is through the bite of an infected mosquito. Mosquitoes become infected when they feed on infected birds, which may circulate the virus in their blood for a few days. The virus eventually gets into the mosquito's salivary

68

Marburg and Ebola Viruses  

Science Journals Connector (OSTI)

The names given to these viruses were derived from the locations where an epidemic developed. Marburg virus was isolated in 1967 from monkeys that were shipped to the German city, Marburg, and from attendants of ...

Yechiel Becker; Julia Hadar

1983-01-01T23:59:59.000Z

69

Viruses and viral proteins  

Science Journals Connector (OSTI)

The X-ray structures of viruses and viral proteins currently available are providing high-resolution snapshots of viral molecular machineries, expanding our vision of the virus world and giving crucial information on potential targets for future antiviral therapies.

Verdaguer, N.

2014-10-14T23:59:59.000Z

70

Wheat Streak Mosaic Virus  

E-Print Network (OSTI)

This publication tells producer about the hazards of wheat streak mosaic virus. It includes information on recognizing affected grain and on preventing infestation....

Morgan, Gaylon

2005-01-26T23:59:59.000Z

71

Reemergence of Chikungunya Virus  

Science Journals Connector (OSTI)

...throughout the Indian Ocean, Pacific, and Caribbean...Organization (WHO) reported the first local transmission of...islands in the Indian Ocean, and this ECSA virus...131.3407.1102 . 3. Powers, AM , AC Brault, RB...viruses causing the Indian Ocean outbreak. PLoS Med...

Thomas E. Morrison

2014-07-30T23:59:59.000Z

72

Generating electricity from viruses  

ScienceCinema (OSTI)

Berkeley Lab's Seung-Wuk Lee discusses "Generating electricity from viruses" in this Oct. 28, 2013 talk, which is part of a Science at the Theater event entitled Eight Big Ideas.

Lee, Seung-Wuk

2014-06-23T23:59:59.000Z

73

Generating electricity from viruses  

SciTech Connect

Berkeley Lab's Seung-Wuk Lee discusses "Generating electricity from viruses" in this Oct. 28, 2013 talk, which is part of a Science at the Theater event entitled Eight Big Ideas.

Lee, Seung-Wuk

2013-10-31T23:59:59.000Z

74

Computer Viruses and Other Hazards  

NLE Websites -- All DOE Office Websites (Extended Search)

Computer Viruses and Other Hazards Computer Viruses and Other Hazards Name: Paul Status: other Grade: 12+ Location: IL Country: USA Date: May 2, 2011 Question: What is a Computer Virus? What do viruses do? How do viruses Spread? How do I prevent a virus? What are Trojan Horse programs? Malware? Phishing? Replies: Paul From National Institute of Science and Technology Which is the US government office in charge of this problem and should be your reference for this subject At this URL: http://csrc.nist.gov/publications/nistpubs/800-61-rev1/SP800-61rev1.pdf Please find the following definitions from paragraph 5: 5.1.1 Virus: A virus is designed to self-replicate-make copies of itself-and distribute the copies to other files, programs, or computers. Viruses insert themselves into host programs and propagate when the infected program is executed, generally by user interaction (e.g., opening a file, running a program, clicking on a file attachment). Viruses have many purposes-some are designed to play annoying tricks, whereas others have destructive intent. Some viruses present themselves as jokes while performing secret destructive functions. There two major types of viruses are compiled viruses, which are executed by the operating system, and interpreted viruses, which are executed by an application.

75

How do viruses form?  

NLE Websites -- All DOE Office Websites (Extended Search)

How do viruses form? How do viruses form? Name: street Location: N/A Country: N/A Date: N/A Question: How do viruses form? Replies: Well, I'll assume you mean how they replicate, since they do not (as far as we know) arise from inorganic materials. Viruses are generally thought of as obligate parasites -- that is, they need the assistance of another organism for their survival. Depending on the type of virus you're looking at you'll see many different ways of accomplishing the same goal -- reproduction. In very general terms, then, a virus will attach itself to an appropriate host cell and insert it's genetic code into the DNA of the host, which then goes thorough it's normal routine of reading through its own code to synthesize proteins and enzymes, and in the process inadvertently replicates the strand of viral DNA (or RNA, depending), which codes for its own proteins and concentrates within the cell. At some point, the cell will not be able to support that many viral particles within it's membrane, and it will die, releasing thousands of new viral particles into the environment to do the dirty deed all over again.

76

Winter Infections: Influenza, Respiratory Syncytial Virus (RSV)  

E-Print Network (OSTI)

spread? Sick person can spread influenza by: ­ Touching ­ Sneezing ­ Coughing Picture: newbedfordguide Fever Cough Fatigue (feel "worn out") Headaches Body aches Runny nose #12;Influenza ("Flu") Treatments paralysis) #12;"MythBusters" Reported That: Sneezes can travel ~35 mph Cough/sneeze droplets can travel

Goldman, Steven A.

77

Production of virus resistant plants  

DOE Patents (OSTI)

A method of suppressing virus gene expression in plants using untranslatable plus sense RNA is disclosed. The method is useful for the production of plants that are resistant to virus infection. 9 figs.

Dougherty, W.G.; Lindbo, J.A.

1996-12-10T23:59:59.000Z

78

Overview of hepatitis E virus  

Science Journals Connector (OSTI)

Hepatitis E virus (HEV) is an enterically transmitted virus usually presenting as an acute self-limiting disease. However, mortality increases dramatically from around 1% to 20% in pregnant women. HEV has been...

Susan Skidmore PhD

2002-01-01T23:59:59.000Z

79

Hepatitis E Virus Infection  

Science Journals Connector (OSTI)

...VA Arankalle, and RH Purcell. 2005. Thermal stability of hepatitis E virus. J. Infect...Garry, N Rose, and N Pavio. 2012. Thermal inactivation of infectious hepatitis E...outbreak among refugees-upper Nile, South Sudan, 2012-2013. MMWR Morb. Mortal. Wkly...

Nassim Kamar; Harry R. Dalton; Florence Abravanel; Jacques Izopet

2014-01-01T23:59:59.000Z

80

Lifestyles of plant viruses  

Science Journals Connector (OSTI)

...rate model, with 10 000 generations. The consensus tree after burn-in was displayed in Mesquite. Viruses names are coloured by...White, J. D., Lai, H., Chavarria, F., Shen, G., Roe, B. A. 2010 Ecogenomics: using massively parallel pyrosequencing...

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Hemagglutinin sequence clusters and the antigenic evolution of influenza A virus  

Science Journals Connector (OSTI)

...http://www.flu.lanl.gov/)]. We use...nine of the last 16 flu seasons, and...used as an effective model of antigenic distances...clusters can be used to predict the next season's...prediction of future outbreaks. 1 Hayden F G Palese...Vaccines genetics Models, Genetic Multigene...

Joshua B. Plotkin; Jonathan Dushoff; Simon A. Levin

2002-01-01T23:59:59.000Z

82

Computer virus information update CIAC-2301  

SciTech Connect

While CIAC periodically issues bulletins about specific computer viruses, these bulletins do not cover all the computer viruses that affect desktop computers. The purpose of this document is to identify most of the known viruses for the MS-DOS and Macintosh platforms and give an overview of the effects of each virus. The authors also include information on some windows, Atari, and Amiga viruses. This document is revised periodically as new virus information becomes available. This document replaces all earlier versions of the CIAC Computer virus Information Update. The date on the front cover indicates date on which the information in this document was extracted from CIAC`s Virus database.

Orvis, W.J.

1994-01-15T23:59:59.000Z

83

E-Print Network 3.0 - acute bacterial infections Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

No. When viruses (e.g. rhinovirus, corona viruses... and influenza) that cause colds and "flu" first infect the nose, sinuses and throat, the ... Source: Virginia Tech, Virginia...

84

Challenges in RNA virus bioinformatics  

Science Journals Connector (OSTI)

......11Division of Computational Systems Biology, Department of Microbiology and Ecosystem Science, Universitat Wien, Althanstrabetae...long-term evolutionary timelines for viruses (Feschotte and Gilbert, 2012). With EVEs it was possible to stretch back the history......

Manja Marz; Niko Beerenwinkel; Christian Drosten; Markus Fricke; Dmitrij Frishman; Ivo L. Hofacker; Dieter Hoffmann; Martin Middendorf; Thomas Rattei; Peter F. Stadler; Armin Tpfer

2014-07-01T23:59:59.000Z

85

Animal Viruses of Genetic Interest  

Science Journals Connector (OSTI)

Early work on the genetics of animal viruses was reviewed, with extensive references, by Fenner and Sambrook (1964), and work done between 1963 and 1969 by Fenner (1970a...). A general account of the biology of a...

Frank Fenner

1975-01-01T23:59:59.000Z

86

LOUISIANA GUIDANCE FOR CLINICIANS ON THE NEED FOR MEDICAL EVALUATION, TESTING, AND TREATMENT OF POSSIBLE NOVEL H1N1 "SWINE"  

E-Print Network (OSTI)

viruses spread by coughing, sneezing and touching contaminated surfaces. The symptoms of the H1N1 flu virus in people are similar to the symptoms of seasonal flu and include fever, cough, sore throat, runny that the child does not want to be held Flu-like symptoms improve but then return with fever and worse cough

87

Should I Work Today? | Flu Information | DHMC Intranet http://intranet.hitchcock.org/hc/webpage.cfm?site_id=1&org_id=393&morg_id=0&gsec_id=36557&item_id=36570&printable=true[5/13/2013 2:25:34 PM  

E-Print Network (OSTI)

Lesions, rashes, and eye conditions may not apply to flu-like illness. COUGH If you have a cough and fever (>100 F or 38 C within the last 24 hours) NO If you have a new (cough, but no fever (, or aspirin) YES, but wear a mask that covers nose and mouth. If you have a prolonged cough of unknown cause

Myers, Lawrence C.

88

Inefficient Transmission of H5N1 Influenza Viruses in a Ferret Contact Model  

Science Journals Connector (OSTI)

...influenza H5N1 outbreaks in Romanian and...a transmission model for influenza...2005. Avian flu: isolation of...a transmission model for human influenza...Animals Disease Models, Animal Disease Outbreaks Ferrets immunology...

Hui-Ling Yen; Aleksandr S. Lipatov; Natalia A. Ilyushina; Elena A. Govorkova; John Franks; Neziha Yilmaz; Alan Douglas; Alan Hay; Scott Krauss; Jerold E. Rehg; Erich Hoffmann; Robert G. Webster

2007-04-25T23:59:59.000Z

89

Is It A Cold Or The Flu? Symptoms Cold Flu  

E-Print Network (OSTI)

Usual Sometimes Sore throat Common Sometimes Chest discomfort, cough Mild-moderate, hacking Common, can fever and cough with medicines you can buy at the store. 5. If you get very sick or are pregnant or have

O'Toole, Alice J.

90

Giant viruses in the oceans : the 4th Algal Virus Workshop  

E-Print Network (OSTI)

Paramecium bursaria chlorella virus (PBCV-1), the prototype of the Phycodnaviridae, was isolated more than 20 bursaria chlorella viruses: NY-2A (infecting PBCV-1 host Chlorella species NC64A) and Chlorella Pbi virus MT325. NY-2A genome contains 368,683 bp, making it the largest chlorella virus sequenced to date

Boyer, Edmond

91

Contribution of Peaks of Virus Load to Simian Immunodeficiency Virus Pathogenesis  

Science Journals Connector (OSTI)

...late peak in virus load. This indicates...the statistical power of this argument...measures the virus load exactly at its...underestimated in virus load data. We studied whether...higher statistical power than model 2...based on the same data (26). However...relation between virus load in plasma and survival...

Roland R. Regoes; Silvija I. Staprans; Mark B. Feinberg; Sebastian Bonhoeffer

2002-03-01T23:59:59.000Z

92

Chimeric gag-V3 virus-like particles of human immunodeficiency virus induce virus-neutralizing antibodies  

Science Journals Connector (OSTI)

...into Spherical Virus-Like Particles. To examine which of the chimeric...assembling into virus- like particles and being secreted into cell...2CD4BD, produced virus-like particles that could be isolated from...C Wt M 1 2 3 4 C Wt 0 |L 'God-- as-F 4iL L D M 1 2 3...

L Luo; Y Li; P M Cannon; S Kim; C Y Kang

1992-01-01T23:59:59.000Z

93

Ebola virus transmission in guinea pigs  

Science Journals Connector (OSTI)

...Rights Reserved. 2014 research-article Ebola virus transmission in guinea pigs Gary...School of Medicine, Philadelphia, PA, USA Ebola virus (EBOV) transmission is currently...movement over short distances. Importance Ebola is generally thought to be spread between...

Gary Wong; Xiangguo Qiu; Jason S. Richardson; Todd Cutts; Brad Collignon; Jason Gren; Jenna Aviles; Carissa Embury-Hyatt; Gary P. Kobinger

2014-11-12T23:59:59.000Z

94

Viruses and viruslike particles of eukaryotic algae.  

Science Journals Connector (OSTI)

...conferred no selective advantage to the virus under these...the viruses remains a disadvantage. The genomes of these...from the Department of Energy (J.V.E.), the...H.M.), and the Solar Energy Re- search Institute...

J L Van Etten; L C Lane; R H Meints

1991-12-01T23:59:59.000Z

95

E-Print Network 3.0 - avian myeloblastosis virus Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

Avian influenza... -Congo haemorrhagic fever virus Coccidioides posadasii Ebola viruses Cercopithecine herpesvirus 1 (Herpes B... virus Lassa ... Source: Fraden,...

96

E-Print Network 3.0 - avian leucosis virus Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Avian influenza... -Congo haemorrhagic fever virus Coccidioides posadasii Ebola viruses Cercopithecine herpesvirus 1 (Herpes B... virus Lassa ... Source: Fraden,...

97

NOVEL INFLUENZA A "SWINE FLU"  

E-Print Network (OSTI)

an infected person sneezes or coughs. People in close (within 3 feet) proximity can become inflected. Steps to protect yourself and others: · Washhandsoftenwithsoapandwater especially after coughs: · Feverof100.4degreesormore · Cough · Bodyaches · Runnynose · Sorethroat · Nausea · Vomiting · Diarrhea

Wiegner, Tracy N.

98

E-Print Network 3.0 - arthritis encephalitis virus Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

THE USE AND MANAGEMENT OF BIOHAZARDOUS MATERIALS Summary: Equine Encephalitis virus Ebola virus Equine Morbillivirus Flexal virus Guanarito virus Hantaan or other... Rift...

99

Chapter 9 - Ebola Virus Disease  

Science Journals Connector (OSTI)

Five species of ebolavirus constitute the genus Ebolavirus, one member of the Filoviridae family. The Bundibugyo, Zaire, and Sudan ebolavirus species cause severe Ebola virus disease (EVD) outbreaks in humans whereas the Reston and Ta Forest species do not. EVD is a febrile hemorrhagic illness, which causes death in 2590% of all clinically ill cases. EVD outbreaks occur primarily in remote villages in Central and West Africa, near tropical rainforests. The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmission. Fruit bats of the Pteropodidae family are considered to be the natural host of the Ebola virus. The laboratory diagnostic remains essential to confirm EVD cases. There is no treatment or vaccine available for either people or animals. Raising awareness of the risk factors of Ebola infection and the protective measures individuals can take is the only way to reduce human infection and death.

Pierre Formenty

2014-01-01T23:59:59.000Z

100

Ebola virus 2014 and pregnancy  

Science Journals Connector (OSTI)

Abstract The Ebola virus 2014 outbreak is the big viral epidemic and cause several deaths. The infection widely spread in Africa and causes infection in thousands of people. The important concern is reproductive medicine is the infection in the pregnant. Here, the authors try to summarize on the information and evidence on this issue and also discuss on the perspective.

Beuy Joob; Viroj Wiwanitkit

2014-01-01T23:59:59.000Z

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101

Treatment of Ebola virus disease  

Science Journals Connector (OSTI)

As of October 17, 2014, a total of 9,216 cases of Ebola virus disease (EVD) and 4,555...1]. Assuming no change in the control measures for this epidemic, which seems to be the most realistic scenario for several ...

Yazdan Yazdanpanah; Jose Ramon Arribas; Denis Malvy

2014-11-01T23:59:59.000Z

102

Virioplankton: Viruses in Aquatic Ecosystems  

Science Journals Connector (OSTI)

...enumerated viruses in water samples, which is necessary...vDNA in the total D-DNA pool. Using the simple approach...less than 20, to D-DNA pools (, , , , ). It is possible...fractions. In the two water samples tested, approximately...These fractions each make up 50 of the total D-DNA...

K. Eric Wommack; Rita R. Colwell

2000-03-01T23:59:59.000Z

103

Plant Immune Responses Against Viruses: How Does a Virus Cause Disease?  

Science Journals Connector (OSTI)

...as a foundational tool for fundamental advances in host-virus...beginning to disentangle the fundamental molecular interactions between...A classical, yet still fundamental approach to study programmed...Virus resistance. In Handbook of Maize: Its Biology...

Kranthi K. Mandadi; Karen-Beth G. Scholthof

2013-05-24T23:59:59.000Z

104

Virus vector gene inserts are stabilized in the presence of satellite panicum mosaic virus coat protein  

E-Print Network (OSTI)

The coat protein of satellite panicum mosaic virus (SPMV) was used to stabilize viral vector gene inserts in planta. A Potato virus X (PVX) vector carrying the SPMV capsid protein (CP) gene was successfully stabilized through three serial passages...

Everett, Anthany Laurence

2009-05-15T23:59:59.000Z

105

African horse sickness virus structure  

Science Journals Connector (OSTI)

African horse sickness virus (AHSV), of which there are nine serotypes (AHSV-1, -2, etc.), is a member of Orbivirus genus within the Reoviridae family. Both in morphology and molecular constituents AHSV particles are comparable to those of bluetongue virus (BTV), the prototype virus of the genus. The two viruses have seven structural proteins (VP17) organized in two layered capsid. The outer capsid is composed of VP2 and VP5. The inner capsid, or core, is composed of two major proteins, VP3 and VP7, and three minor proteins, VP1, VP4 and VP6. Within the core is the virus genome. This genome consists of 10 double-stranded (ds)RNA segments of different sizes, three large, designated L1L3, three medium, M4M6, and four small, S7S10. In addition to the seven stuctural proteins that are coded by seven of the RNA species, four non-structural proteins, NS1, NS2, NS3 and NS3A, are coded by three RNA segments, M5, S8 and S10. The two smallest proteins (NS3 and NS3A) are synthesized by the S10 RNA segment, probably from different in-frame translation initiation codons. Nucleotide sequences of eight RNA segments (L2, L3, M4, M5, M6, S7, S8 and S10) and the predicted amino acid sequences of the encoded gene products are also available, mainly representing one serotype, AHSV-4. In this review the properties of the AHSV genes and gene products are discussed. The sequence and hybridization analyses of the different AHSV dsRNA segments indicate that the segments that code for the core proteins, as well as those that code for NS1 and NS2 proteins, are highly conserved between the different virus serotypes. However, the RNA encoding NS3 and NS3A, and the two segments encoding the outer capsid proteins, are more variable between the AHSV serotypes. A close phylogenetic relationship between AHSV, BTV and epizootic haemorrhagic disease virus (EHDV), three Culicoides-transmitted orbiviruses, has been revealed when the equivalent sequences of genes and gene products are compared. Recently, the four major AHSV capsid proteins have been expressed using recombinant baculoviruses. Biochemically and antigenically these proteins are similar to the authentic proteins. Since the AHSV VP7 protein is highly conserved among the different serotypes, it has been utilized as a diagnostic reagent. The expressed VP7 protein has also been purified to homogeneity and crystallized for three-dimensional X-ray analysis. The expressed outer capsid proteins, VP2 and VP5, have been purified and used to raise antisera in rabbits. The VP2 antisera neutralize virus infections in vitro indicating the importance of this protein for vaccine development.

Polly Roy; Peter P.C. Mertens; Ignacio Casal

1994-01-01T23:59:59.000Z

106

Tracking Ebola virus within host cells  

Science Journals Connector (OSTI)

Confocal microscopy reveals that Ebola virus exploits its host cells' own internal scaffolding to help it self-assemble and move.

107

Volatiles from potato plants infected with potato leafroll virus attract and arrest the virus vector, Myzus persicae (Homoptera: Aphididae)  

Science Journals Connector (OSTI)

7 March 2002 research-article Volatiles from potato plants infected with potato leafroll virus attract and arrest the virus vector...previously reported preferential colonization of potatoes infected by potato leafroll virus (genus Polerovirus...

2002-01-01T23:59:59.000Z

108

Increased transmissibility explains the third wave of infection by the 2009 H1N1 pandemic virus in England  

Science Journals Connector (OSTI)

...Medical Sciences Models of Infectious Disease...2013 MRC Centre for Outbreak Analysis and Modelling...National Pandemic Flu Service...5 1.4 The model...the ability of the model to predict excluded data. We...

Ilaria Dorigatti; Simon Cauchemez; Neil M. Ferguson

2013-01-01T23:59:59.000Z

109

Ebola virus: the search for vaccines and treatments  

Science Journals Connector (OSTI)

Ebola viruses belong to the family Filoviridae, which ... available for human use. This review describes Ebola viruses, with a particular focus on the...

J.A. Wilson; C.M. Bosio; M.K. Hart

2001-11-01T23:59:59.000Z

110

Experimental inoculation of BALB C mice with Ebola virus.  

E-Print Network (OSTI)

??Ebola virus is the causative agent of a severe hemorrhagic fever with fatality rates in humans approaching 90% with the Zaire species of the virus. (more)

Stockton, Patrick Carroll

2002-01-01T23:59:59.000Z

111

Teaching themes Entry of viruses into cells: receptor binding, structural basis of the entry process and uncoating.  

E-Print Network (OSTI)

important human and animal diseases are caused by RNA viruses - Influenza, Measles, SARS, Ebola, Polio Nadurelia capensis virus MS25CCMV Influenza virus Ebola virusMeasles virus SARS virus calicviruses dengue

Brierley, Andrew

112

Pathogenic Interactions Between Sorghum Yellow Banding Virus and Other Viruses Infecting Sorghum.  

E-Print Network (OSTI)

Between Sorghum Yellow Banding Virus and Other Viruses Infecting Sorghum M.P.K.J. Theu and R. W. Toler1 Abstract A pathogenic interaction between sorghum yel low banding virus (SYBV) and maize dwarf mosaic (MDMV-A) virus was proved. Inoculation... Microscope Operation. 6th ed. North-Holland., Amsterdam. 326 pp. 3 2. McClelen, C.E., and R.W. Toler. 1989. The ultra structural aspects of infection of Zea mays c.v. Silver Queen by sorghum yellow banding virus (SYBV). (ABSTR.) Phytopathology 79...

Theu, M.P.K.J; Toler, R.W.

1992-01-01T23:59:59.000Z

113

Molecular virology of EpsteinBarr virus  

Science Journals Connector (OSTI)

...Epstein^ Barr virus (EBV) genome.Virology 166, 586^590. Schaefer, B. C., Strominger, J. L. & Speck, S. H. 1995 Rede ning the Epstein^Barr virus-encoded nuclear antigen EBNA-1 gene promoter and transcription initiation site in group I Burkitt...

2001-01-01T23:59:59.000Z

114

Ebola Virus Does Not Block Apoptotic Signaling Pathways  

Science Journals Connector (OSTI)

...research-article Virus-Cell Interactions Ebola Virus Does Not Block Apoptotic Signaling...determine the mechanism of cell death caused by Ebola virus (EBOV) infection by assaying for...of antiviral therapeutics. INTRODUCTION Ebola viruses are members of the filovirus family...

Judith Olejnik; Jesus Alonso; Kristina M. Schmidt; Zhen Yan; Wei Wang; Andrea Marzi; Hideki Ebihara; Jinghua Yang; Jean L. Patterson; Elena Ryabchikova; Elke Mhlberger

2013-03-06T23:59:59.000Z

115

Review article Molecular biology of fish viruses: a review  

E-Print Network (OSTI)

Review article Molecular biology of fish viruses: a review J Bernard, M Brémont* INRA, laboratoire aspects in the fish virus studies. Although more than 50 different fish virus have been isolated family, the fish lym- phocystis disease virus (FLDV) is the most studied. Retroviridae have been recently

Boyer, Edmond

116

Mutation, purification and chemical studies on the tobacco necrosis virus  

E-Print Network (OSTI)

? ............ . ? 100 XI Effect of pH on the infectivity of tobacco necrosis virus ........ ? ? ? ? ? ? ? ? ? ? 102 XII Effect of various treatments on the infec? tivity of tobacco necrosis virus in situ ? ? 104 XIII Susceptibility of various host plants... necrosis virus ................... . . . . . . . . 131 l?b Re-precipitation of tobacco necrosis virus with ethanol ? ........ ? 131 19 Effect of various combination treatments on tobacco necrosis virus ? ? ? . . ? ? ? ? 134 20 Sedimentation...

Hockaday, William Don

1957-01-01T23:59:59.000Z

117

Human adaptation of avian influenza viruses  

E-Print Network (OSTI)

Human adaptation of avian influenza viruses pose an enormous public health challenge as the human population is predominantly naive to avian influenza antigens. As such, constant surveillance is needed to monitor the ...

Srinivasan, Karunya

2012-01-01T23:59:59.000Z

118

Pandora of Ebola virus: are we ready?  

Science Journals Connector (OSTI)

On 23 March 2014, the ministry of health of Guinea notified WHO of a rapidly spreading outbreak of Ebola virus disease (EVD) in south-eastern... ...http://www.who.int/csr/don/2014_07_31_ebola/en/ ...

Ruifu Yang

2014-11-01T23:59:59.000Z

119

Ebola Virus Exploits a Monocyte Differentiation Program To Promote Its Entry  

Science Journals Connector (OSTI)

...research-article Virus-Cell Interactions Ebola Virus Exploits a Monocyte Differentiation...cells (APCs) are critical targets of Ebola virus (EBOV) infection in vivo. However...limit APC infection. INTRODUCTION Zaire Ebola virus (EBOV) is an emerging zoonotic...

Osvaldo Martinez; Joshua C. Johnson; Anna Honko; Benjamin Yen; Reed S. Shabman; Lisa E. Hensley; Gene G. Olinger; Christopher F. Basler

2013-01-23T23:59:59.000Z

120

Protection from Ebola Virus Mediated by Cytotoxic T Lymphocytes Specific for the Viral Nucleoprotein  

Science Journals Connector (OSTI)

...AND ANTIVIRAL AGENTS Protection from Ebola Virus Mediated by Cytotoxic T Lymphocytes...from intracellular pathogens such as Ebola virus. However, there have been no demonstrations that protection against Ebola virus is mediated by Ebola virus-specific...

Julie A. Wilson; Mary Kate Hart

2001-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
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to obtain the most current and comprehensive results.


121

Ebola Virus Modulates Transforming Growth Factor ? Signaling and Cellular Markers of Mesenchyme-Like Transition in Hepatocytes  

Science Journals Connector (OSTI)

...research-article Virus-Cell Interactions Ebola Virus Modulates Transforming Growth Factor...contributed equally to this publication. Ebola virus (EBOV) causes a severe hemorrhagic...signaling responses in the pathogenesis of Ebola virus disease. IMPORTANCE Ebola virus...

Jason Kindrachuk; Victoria Wahl-Jensen; David Safronetz; Brett Trost; Thomas Hoenen; Ryan Arsenault; Friederike Feldmann; Dawn Traynor; Elena Postnikova; Anthony Kusalik; Scott Napper; Joseph E. Blaney; Heinz Feldmann; Peter B. Jahrling

2014-06-18T23:59:59.000Z

122

Ab and T cell epitopes of influenza A virus, knowledge and opportunities  

Science Journals Connector (OSTI)

...reassortants. Seasonal outbreaks are caused by subtypes...not only as a model system, but...well as tools to predict epitope cellular...Database (www.flu.lanl.gov...data from human models, because the repertoire...recognized in animal model systems. Table...2004 H5N1 outbreaks, respectively...

Huynh-Hoa Bui; Bjoern Peters; Erika Assarsson; Innocent Mbawuike; Alessandro Sette

2007-01-01T23:59:59.000Z

123

Protective immunity to lethal challenge of the 1918 pandemic influenza virus by vaccination  

Science Journals Connector (OSTI)

...infection in mice. This model has provided an opportunity...developed to contain outbreaks. Results Generation...and www.cdc.gov/flu/h2n2bsl3.htm). Both...the lethal challenge model was readily measured...explore its ability to predict protective immunity...

Wing-pui Kong; Chantelle Hood; Zhi-yong Yang; Chih-Jen Wei; Ling Xu; Adolfo Garca-Sastre; Terrence M. Tumpey; Gary J. Nabel

2006-01-01T23:59:59.000Z

124

The Ebola Virus VP35 Protein Inhibits Activation of Interferon Regulatory Factor 3  

Science Journals Connector (OSTI)

...Microbiology ARTICLE VIRUS-CELL INTERACTIONS The Ebola Virus VP35 Protein Inhibits Activation...Marburg, D-35037 Marburg, Germany The Ebola virus VP35 protein was previously found...virus IFN antagonist protein, NS1. The Ebola virus VP35 could also prevent the virus...

Christopher F. Basler; Andrea Mikulasova; Luis Martinez-Sobrido; Jason Paragas; Elke Mhlberger; Mike Bray; Hans-Dieter Klenk; Peter Palese; Adolfo Garca-Sastre

2003-07-01T23:59:59.000Z

125

Zanamivir, at 600 Milligrams Twice Daily, Inhibits Oseltamivir-Resistant 2009 Pandemic H1N1 Influenza Virus in an In Vitro Hollow-Fiber Infection Model System  

Science Journals Connector (OSTI)

...www.cdc.gov/flu/weekly/ . 8 CDC...hollow-fiber infection model system. Antimicrob...first 2009 influenza outbreak in Mexico City. J...hollow-fiber infection model system. | In 2009...infection model system to predict optimal dosing regimens...

Ashley N. Brown; James J. McSharry; Qingmei Weng; Jonathan R. Adams; Robert Kulawy; George L. Drusano

2011-01-24T23:59:59.000Z

126

Dengue Virus Induces and Requires Glycolysis for Optimal Replication  

Science Journals Connector (OSTI)

...Biology Program, University of Washington, Seattle, Washington, USA Viruses rely on host cellular metabolism to provide the energy and biosynthetic building blocks required for their replication. Dengue virus (DENV), a member of the Flaviviridae family...

Krystal A. Fontaine; Erica L. Sanchez; Roman Camarda; Michael Lagunoff

2014-12-10T23:59:59.000Z

127

Ebola Virus Pathogenesis: Implications for Vaccines and Therapies  

Science Journals Connector (OSTI)

...American Society for Microbiology MINIREVIEW Ebola Virus Pathogenesis: Implications for Vaccines...Institutes of Health, Bethesda, Maryland Ebola virus is an aggressive pathogen that causes...nonhuman primates. First recognized near the Ebola River valley during an outbreak in Zaire...

Nancy Sullivan; Zhi-Yong Yang; Gary J. Nabel

2003-09-01T23:59:59.000Z

128

Mechanisms Regulating Nucleocapsid Formation of the Hepatitis B Viruses  

Science Journals Connector (OSTI)

The hepatitis B viruses are a group of small enveloped DNA viruses which are characterized by a distinct liver tropism and a narrow host range. The most important member of the hepadnavirus group is the human ...

Ralf Bartenschlager; Heinz Schaller

1993-01-01T23:59:59.000Z

129

Treatment of tumors with genetically engineered herpes virus  

DOE Patents (OSTI)

Disclosed are methods for treating cancer by administering an effective amount of a modified Herpes simplex virus.

Weichselbaum, Ralph R; Roizman, Bernard; Whitley, Richard J

2012-11-27T23:59:59.000Z

130

Infection with Strains of Citrus Tristeza Virus Does Not Exclude Superinfection by Other Strains of the Virus  

Science Journals Connector (OSTI)

...distinct strains. However, this model does not explain how hybrid viruses containing...Graft-transmissible diseases of detritus: handbook for detection and diagnosis. FAO, Rome...Infection with strains of Citrus tristeza virus does not exclude superinfection by other strains...

Svetlana Y. Folimonova; Cecile J. Robertson; Turksen Shilts; Alexey S. Folimonov; Mark E. Hilf; Stephen M. Garnsey; William O. Dawson

2009-11-18T23:59:59.000Z

131

Automatic RNA virus classification using the Entropy-ANFIS method  

Science Journals Connector (OSTI)

Innovations in the fields of medicine and medical image processing are becoming increasingly important. Historically, RNA viruses produced in cell cultures have been identified using electron microscopy, in which virus identification is performed by ... Keywords: ANFIS, Center-edge change method, Classification, Clustering, DNA, Entropy, FCM, RNA, RNA virus images

Esin Dogantekin; Engin Avci; Oznur Erkus

2013-07-01T23:59:59.000Z

132

Phonon Confinement Effects in Hybrid Virus-Inorganic Nanotubes for  

E-Print Network (OSTI)

Phonon Confinement Effects in Hybrid Virus-Inorganic Nanotubes for Nanoelectronic Applications as nanotemplates, viruses can actually improve the electron transport properties in semiconductor nanotubes grown nanotubes deposited on tobacco mosaic viruses, the confined acoustic phonons are found to be redistributed

Fonoberov, Vladimir

133

Segmented genome and nucleocapsid of La Crosse virus.  

Science Journals Connector (OSTI)

...accommodated within the nascent virus particle. However, we have so far been unable...25, 36). They stated that "'virus particles stored at 4?C spontaneously release...Sponta- neously disrupted virus particles released strands as long as 1,000 nm...

J F Obijeski; D H Bishop; E L Palmer; F A Murphy

1976-12-01T23:59:59.000Z

134

Ebola Virus Disease The current outbreak of Ebola Virus Disease (EVD) in West Africa has involved the  

E-Print Network (OSTI)

Ebola Virus Disease The current outbreak of Ebola Virus Disease (EVD) in West Africa has involved the countries of Sierra Leone, Liberia, Guinea, and Nigeria. This has become the largest outbreak of Ebola want to make sure you have the most accurate information about this illness. What is Ebola Virus

MacAdam, Keith

135

Production of Novel Ebola Virus-Like Particles from cDNAs: an Alternative to Ebola Virus Generation by Reverse Genetics  

Science Journals Connector (OSTI)

...Microbiology ARTICLE REPLICATION Production of Novel Ebola Virus-Like Particles from cDNAs: an Alternative to Ebola Virus Generation by Reverse Genetics Shinji...plasmid-based system for generating infectious Ebola virus-like particles (VLPs), which contain...

Shinji Watanabe; Tokiko Watanabe; Takeshi Noda; Ayato Takada; Heinz Feldmann; Luke D. Jasenosky; Yoshihiro Kawaoka

2004-01-01T23:59:59.000Z

136

Characterization of virus produced by a lymphoma induced by inoculation of AKR MCF-247 virus.  

Science Journals Connector (OSTI)

...Present address: Laboratory of Nuclear Medicine and Radiation Biology, Los Angeles, CA 90024. : Present address...and T. Pincus. 1972. Quantitative studies of naturally occuring murine leukemia virus infections of AKR mice. J...

F S Pedersen; D L Buchhagen; C Y Chen; E F Hays; W A Haseltine

1980-07-01T23:59:59.000Z

137

The Effect of Mumps Virus on the Resistance of Burkitt Lymphoma Cell Lines to Various Viruses  

Science Journals Connector (OSTI)

...evidence for transmission of EBV. The...lymphoma cell lines to various viruses...evidence for transmission of EBV. INTRODUCTION Lines of blastoid cells...intracerebral routes. The animals...infection of cell lines derived from...

Barbara A. Zajac; Werner Henle; and Gertrude Henle

1969-02-01T23:59:59.000Z

138

Dveloppement d'un vecteur virus de la vaccine, rplicatif et attnu, pour la vaccination antivariolique et pour la vaccination contre la fivre hmorragique virus Ebola.  

E-Print Network (OSTI)

??Le virus Ebola, responsable d'une fivre hmorragique virale ltale et le virus de la variole, agent tiologique de la variole, sont des armes biologiques potentielles. (more)

Dimier, Julie

2012-01-01T23:59:59.000Z

139

Analysis of the Host Stress Response to Ebola Virus Infection and Generation of a Recombinant Marburg Virus Expressing EGFP to Study Viral Spread.  

E-Print Network (OSTI)

??Ebola virus (EBOV) and Marburg virus (MARV) belong to the filovirus family and cause outbreaks with case fatality rates up to 90%. Currently there is (more)

Schmidt, Kristina Maria

2012-01-01T23:59:59.000Z

140

Virus Cell-to-Cell Transmission  

Science Journals Connector (OSTI)

...viruses do not recruit an individual myosin motor to each particle but, rather, utilize...spread of alpha-herpesvirus infection. Future Virol. 4: 591. 25 Das, V., B. Nal...Jares-Erijman, and T. M. Jovin. 2004. Quantum dot ligands provide new insights into...

Walther Mothes; Nathan M. Sherer; Jing Jin; Peng Zhong

2010-04-07T23:59:59.000Z

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Multiparameter light scattering for rapid virus identification  

SciTech Connect

An instrument for making multiparameter light scattering (MLS) measurements from viral suspensions has been described. Calibration methods and a technique for the correction of artifacts were also presented. This measurement technique may have broad applications in cell biology in general and in virology in particular. It may be possible to use MLS to identify viruses directly from clinical specimens. 8 references, 7 figures.

Salzman, G.C.; Grace, W.K.; McGregor, D.M.; Gregg, C.T.

1984-01-01T23:59:59.000Z

142

Pathogenesis of human immunodeficiency virus infection.  

Science Journals Connector (OSTI)

...in helper T-cell function (1085). F. Anti-Lymphocyte Antibodies...cannot replicate in the brain (1079), and certain macrophage-tropic...blood-brain barrier (739, 1080). Therefore, their inability...macrophages were not found in the CNS (1080). Thus, entry of free virus...

J A Levy

1993-03-01T23:59:59.000Z

143

Pathogenic Human Viruses in Coastal Waters  

Science Journals Connector (OSTI)

...of viruses is heat stable and more...excreted into the water column by mammals...disease after swimming at polluted beaches...caliciviruses in marine water maintained at...with municipal water system. J...associated with swimming in a pool and secondary...

Dale W. Griffin; Kim A. Donaldson; John H. Paul; Joan B. Rose

2003-01-01T23:59:59.000Z

144

Ecological dynamics of emerging bat virus spillover  

Science Journals Connector (OSTI)

...Center, National Institutes of Health. Figure-1. Enabling conditions...Nipah viruses: different and dangerous. Nat. Rev. Microbiol. 4...but a relatively minor public health threat for Africa. Clin...a review. Zoonoses Public health 60, 104-116. ( doi:10...

2015-01-01T23:59:59.000Z

145

Specific Nucleoprotein Residues Affect Influenza Virus Morphology  

Science Journals Connector (OSTI)

...these residues to the crystal structure of NP, we...in the production of spherical virions, as indicated...WSN-AichiM1 virus. (A) Crystal structure of NP highlighting...M1 to form straight or bent elongated ribbons and...filamentous virions to spherical ones. We anticipate...

Kristy M. Bialas; Kendra A. Bussey; Raychel L. Stone; Toru Takimoto

2013-12-11T23:59:59.000Z

146

Molecular biology of the human immunodeficiency virus type 1  

SciTech Connect

The immunodeficiency virus type 1 ia a complex retrovirus. In addition to genes that specify the proteins of the virus particle and the replicative enzymes common to all retroviruses, HIV-1 specifies at least six additional proteins that regulate the virus cycle. Two of these regulatory genes, tat and rev, specify proteins essential for replication. These proteins bind to specific sequences of newly synthesized virus RNA and profoundly affect virus protein expression. Tat and rev appear to be prototypes of novel eukaryotic regulatory proteins. These two genes may play a central role in regulating the rate of virus replication. Three other viral genes, vif, vpu, and vpr, affect the assembly and replication capacity of newly made virus particles. These genes may play a critical role in spread of the virus from tissue to tissue and from person to person. Our understanding of the contribution of each of the virus structural proteins and regulatory genes to the complex life cycle of the virus in natural infections is incomplete. However, enough insight has been gained into the structure and function of each of these components to provide a firm basis for rational antiviral drug development.

Haseltine, W.A. (Harvard Medical School, Boston, MA (United States))

1991-07-01T23:59:59.000Z

147

flu preparations Wash your hands, cover  

E-Print Network (OSTI)

and audiology. Koop currently co-leads the three-year GenomicsinLiceandSalmonprojectusing advanced genomics in Genomics and Molecular Biology. He was also part of the world-wide team of scientists who mapped the human genome. Koop's team is

Victoria, University of

148

Chapter 8 - Rift Valley Fever Virus: A Virus with Potential for Global Emergence  

Science Journals Connector (OSTI)

Abstract Rift Valley fever virus (RVFV) is an important emerging zoonotic threat to veterinary and public health with potential to cause a severe socioeconomic impact on peoples livelihoods. The capacity of the virus to spread into new territories by crossing significant natural geographic barriers and re-emerge in endemic regions after long periods of silence, to cause large outbreaks in human and animal populations, constitutes a formidable challenge for public and veterinary health authorities as well as for scientific communities worldwide. In spite of recent advances in research on RVFV pathogenesis, molecular epidemiology, outbreak prediction, and development of new diagnostic tools and vaccines, some fundamental aspects of the epidemiology and ecology of the virus remain elusive. Large outbreaks of RVF are associated with anomalous high rainfalls leading to massive flooding and the resultant swarms of competent mosquito vectors transmitting the virus to a wide range of susceptible vertebrate species. However, the exact mechanism of RVFV natural transmission during interepizootic periods remains largely unknown, including the postulated long-term virus persistence in transovarially infected eggs of floodwater Aedes mosquito species, and the role of wild mammals as reservoirs. The presence of competent mosquito vectors in countries free of RVF, the wide range of mammals susceptible to the virus, the global changes in climate, and increased animal trade and travel are some of the factors that might contribute to international spread. This chapter provides the background to the major outbreaks, molecular biology and epidemiology of RVFV, and overviews aspects of ecology, host and vector range which make the virus a potential global emerging threat.

Janusz T. Paweska; Petrus Jansen van Vuren

2014-01-01T23:59:59.000Z

149

Mutations in Sendai virus variant F1-R that correlate with plaque formation in the absence of trypsin  

Science Journals Connector (OSTI)

With the emergence of new viruses, such as the SARS virus and the avian influenza virus, the importance of investigations on the genetic basis of viral infections becomes clear. Sendai virus causes a localized re...

Xiaogang Hou; Edgar Suquilanda; Ana Zeledon

2005-05-01T23:59:59.000Z

150

Ebola Virus Can Be Effectively Neutralized by Antibody Produced in Natural Human Infection  

Science Journals Connector (OSTI)

ARTICLE PATHOGENESIS AND IMMUNITY Ebola Virus Can Be Effectively Neutralized by...recombinant human monoclonal antibodies to Ebola virus antigens was isolated from phage...who recovered from infection in the 1995 Ebola virus outbreak in Kikwit, Democratic Republic...

Toshiaki Maruyama; Luis L. Rodriguez; Peter B. Jahrling; Anthony Sanchez; Ali S. Khan; Stuart T. Nichol; C. J. Peters; Paul W. H. I. Parren; Dennis R. Burton

1999-07-01T23:59:59.000Z

151

Ebola Virus Glycoprotein Toxicity Is Mediated by a Dynamin-Dependent Protein-Trafficking Pathway  

Science Journals Connector (OSTI)

ARTICLE PATHOGENESIS AND IMMUNITY Ebola Virus Glycoprotein Toxicity Is Mediated...Institutes of Health, Bethesda, Maryland Ebola virus infection causes a highly lethal...effects, the molecular events that underlie Ebola virus cytopathicity are poorly understood...

Nancy J. Sullivan; Mary Peterson; Zhi-yong Yang; Wing-pui Kong; Heinricus Duckers; Elizabeth Nabel; Gary J. Nabel

2005-01-01T23:59:59.000Z

152

Silicates as Nonspecific Adsorbents of Bacteriophage: a Model for Purification of Water from Viruses  

Science Journals Connector (OSTI)

...Bacteriophage: a Model for Purification of Water from Viruses Refael Fass Yochevet...bacteriophage: a model for purification of water from viruses. | Amorphous...Bacteriophage: a Model for Purification of Water from Viruses REFAEL FASS...

Refael Fass; Yochevet Straussman; Abraham Shahar; Avshalom Mizrahi

1980-01-01T23:59:59.000Z

153

The Herpes Simplex Virus Type 1 UL20 Protein Modulates Membrane Fusion Events during Cytoplasmic Virion Morphogenesis and Virus-Induced Cell Fusion  

Science Journals Connector (OSTI)

...Herpes Simplex Virus Type 1 UL20 Protein Modulates Membrane Fusion Events during Cytoplasmic...that affect cell fusion in herpes simplex virus type 1. Virology 132...virus-induced cell fusion. | The herpes simplex virus type 1 (HSV-1) UL20...

Timothy P. Foster; Jeffrey M. Melancon; Joel D. Baines; Konstantin G. Kousoulas

2004-05-01T23:59:59.000Z

154

Bioterrorism Preparedness: Smallpox and Related Pox Viruses  

E-Print Network (OSTI)

(strains produced by combining genes from different organisms). Credible experts fear that, since the fall of Communism, these viruses The last endemic case of smallpox occurred in Somalia in October 1977. Before this, smallpox killed more peo- ple than any... to 17 day range) and is not contagious until a rash appears. If vaccination is performed within the first few days (and perhaps as late as four days) of exposure, illness from smallpox may be significantly reduced. The United States maintains a stock...

Lawhorn, D. Bruce

2002-04-24T23:59:59.000Z

155

Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies  

Science Journals Connector (OSTI)

...that caused the disease outbreak in Turkey. Library Construction...during the 1918 Spanish flu pandemic. Conversely...is observed, one can predict that other members of the group to...space-filling (Lower) models. A tight cluster...during the 1918 influenza outbreak. The second...

Arun K. Kashyap; John Steel; Ahmet F. Oner; Michael A. Dillon; Ryann E. Swale; Katherine M. Wall; Kimberly J. Perry; Aleksandr Faynboym; Mahmut Ilhan; Michael Horowitz; Lawrence Horowitz; Peter Palese; Ramesh R. Bhatt; Richard A. Lerner

2008-01-01T23:59:59.000Z

156

ALS Capabilities Reveal Multiple Functions of Ebola Virus  

NLE Websites -- All DOE Office Websites (Extended Search)

ALS Capabilities Reveal Multiple Functions of Ebola Virus Print A central dogma of molecular biology is that a protein's sequence dictates its fold, and the fold dictates its...

157

Structure-function analysis of Ebola virus glycoproteins.  

E-Print Network (OSTI)

??As a result of transcriptional editing, Ebola virus (EBOV) produces multiple soluble products from its glycoprotein gene, the primary product of which is the secreted (more)

Falzarano, Darryl Lee

2010-01-01T23:59:59.000Z

158

The Potato Virus "X": Its Strains and Reactions  

Science Journals Connector (OSTI)

30 September 1938 research-article The Potato Virus "X": Its Strains and Reactions Redcliffe N. Salaman The Royal Society is collaborating with JSTOR to digitize, preserve...

1938-01-01T23:59:59.000Z

159

Brief Report: Life-Threatening Cache Valley Virus Infection  

Science Journals Connector (OSTI)

...cerebrospinal fluid sample obtained on December 1, 1995. Discussion. We describe disease caused by Cache Valley virus in a human. Viremia was detected seven days after the onset of fever, an unusually long period of viremia in the case of most Bunyaviridae infections, and the virus had clearly entered the... The Bunyamwera serogroup (family Bunyaviridae, genus bunyavirus) contains more than 20 serologically cross-reactive viruses, 7 of which have been isolated in North America.1 Cache Valley virus, first isolated in Utah in 1956,2 has been recovered mainly ...

Sexton D.J.; Rollin P.E.; Breitschwerdt E.B.

1997-02-20T23:59:59.000Z

160

The structure and evolution of the major capsid protein of a large, lipid-containing DNA virus  

E-Print Network (OSTI)

bursaria Chlorella virus type 1 (PBCV-1) is a very large, icosahedral virus containing an internal membrane image reconstruction of the virus. Chlorella viruses, isolated from freshwater sources throughout and to iridoviruses (3, 4) such as Chilo iridescent virus (1). Paramecium bursaria Chlorella virus (PBCV), genus

Rossmann, Michael G.

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Effect of ebola virus reinoculations on the time course of immunological parameters  

Science Journals Connector (OSTI)

Three inoculations of live and inactivated Ebola virus to susceptible (guinea pigs) and ... pigs. Similar immunogenicity of live and inactivated Ebola virus for guinea pigs and a higher...

A. A. Chepurnov; A. A. Dadaeva

1999-01-01T23:59:59.000Z

162

E-Print Network 3.0 - animal viruses nsv Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiobiological Studies of Vaccinia Virus' Summary: of a few animal viruses (Dulbecco and Vogt, 1955 ; Frank- lin, 1958; Powell, 1959; Kaplan, 1962)) but... , owing partly to a...

163

Genomics of bacterial and archaeal virus isolates from extreme aquatic environments.  

E-Print Network (OSTI)

??Viruses are ubiquitous, abundant and diverse members of the biosphere. Numerous sequencing projects focusing on isolated viruses and uncultured viral communities (metaviromes) have demonstrated that (more)

Sencilo, Ana

2014-01-01T23:59:59.000Z

164

E-Print Network 3.0 - arthritis-encephalitis virus surface Sample...  

NLE Websites -- All DOE Office Websites (Extended Search)

host surface membrane or receptor... virus capsid and water environment is modeled by the surface tension. The non-bonding interactions... between the virus capsid subunits and...

165

Isolation and identification of the Sersenk strain of goat pox virus in Iraq  

Science Journals Connector (OSTI)

Goat pox virus was isolated during an outbreak of pox infection among goats in the Sersenk district, Iraq. The isolated virus grew on the chorioallantoic...

H. H. Tantawi; M. O. Shony; F. K. Hassan

1979-02-01T23:59:59.000Z

166

E-Print Network 3.0 - al virus huasteco Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

and characterized... 499442 Pepper huasteco yellow vein virus PHYVV X70418, X70419 Potato yellow mosaic virus... ;1702 P. L. Ramos et al. Fig. 1. Diagrammatic ... Source:...

167

E-Print Network 3.0 - apple mosaic virus Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

translation of plant viral RNAs Summary: in capped RNAs such as those of Potato virus X (Smirnyagina et al., 1991) and Tobacco mosaic virus (Gallie... , including...

168

Science Summary  

NLE Websites -- All DOE Office Websites (Extended Search)

Liddington Research Liddington Research Burnham News Release Dana-Farber Cancer Institute Centers for Disease Control and Prevention » Videos Attacking Influenza Scientists Identify Antibodies Super Flu Vaccine » Share this Article Laboratree Ologeez SciLink LabSpaces Scientists Identify Achilles' Heel of Flu Viruses Scientists have recently identified a family of human antibodies that can take out an unprecedented number of different types of flu viruses, including H5N1 'bird flu' and the 1918 H1N1 'Spanish flu', which killed millions around the world during World War I, as well as seasonal flu. Using SSRL's Beam Line 9-2, Dr. Robert Liddington from the Burnham Institute for Medical Research led a team of scientists that determined the crystal structure of one such antibody, F10, in complex with the

169

Chimeric human parainfluenza virus bearing the Ebola virus glycoprotein as the sole surface protein is immunogenic and highly protective against Ebola virus challenge  

SciTech Connect

We generated a new live-attenuated vaccine against Ebola virus (EBOV) based on a chimeric virus HPIV3/{delta}F-HN/EboGP that contains the EBOV glycoprotein (GP) as the sole transmembrane envelope protein combined with the internal proteins of human parainfluenza virus type 3 (HPIV3). Electron microscopy analysis of the virus particles showed that they have an envelope and surface spikes resembling those of EBOV and a particle size and shape resembling those of HPIV3. When HPIV3/{delta}F-HN/EboGP was inoculated via apical surface of an in vitro model of human ciliated airway epithelium, the virus was released from the apical surface; when applied to basolateral surface, the virus infected basolateral cells but did not spread through the tissue. Following intranasal (IN) inoculation of guinea pigs, scattered infected cells were detected in the lungs by immunohistochemistry, but infectious HPIV3/{delta}F-HN/EboGP could not be recovered from the lungs, blood, or other tissues. Despite the attenuation, the virus was highly immunogenic, and a single IN dose completely protected the animals against a highly lethal intraperitoneal challenge of guinea pig-adapted EBOV.

Bukreyev, Alexander [National Institute of Allergy and Infectious Diseases, Building 50, Room 6505, NIAID, National Institutes of Health, 50 South Dr. MSC 8007, Bethesda, MD 20892-8007 (United States)], E-mail: abukreyev@nih.gov; Marzi, Andrea; Feldmann, Friederike [Special Pathogens Program, National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg (Canada); Zhang Liqun [Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Yang Lijuan; Ward, Jerrold M. [National Institute of Allergy and Infectious Diseases, Building 50, Room 6505, NIAID, National Institutes of Health, 50 South Dr. MSC 8007, Bethesda, MD 20892-8007 (United States); Dorward, David W. [Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana (United States); Pickles, Raymond J. [Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Murphy, Brian R. [National Institute of Allergy and Infectious Diseases, Building 50, Room 6505, NIAID, National Institutes of Health, 50 South Dr. MSC 8007, Bethesda, MD 20892-8007 (United States); Feldmann, Heinz [Special Pathogens Program, National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg (Canada); Department of Medical Microbiology, University of Manitoba (Canada); Collins, Peter L. [National Institute of Allergy and Infectious Diseases, Building 50, Room 6505, NIAID, National Institutes of Health, 50 South Dr. MSC 8007, Bethesda, MD 20892-8007 (United States)

2009-01-20T23:59:59.000Z

170

A replication-deficient rabies virus vaccine expressing Ebola virus glycoprotein is highly attenuated for neurovirulence  

SciTech Connect

We are developing inactivated and live-attenuated rabies virus (RABV) vaccines expressing Ebola virus (EBOV) glycoprotein for use in humans and endangered wildlife, respectively. Here, we further characterize the pathogenesis of the live-attenuated RABV/EBOV vaccine candidates in mice in an effort to define their growth properties and potential for safety. RABV vaccines expressing GP (RV-GP) or a replication-deficient derivative with a deletion of the RABV G gene (RV{Delta}G-GP) are both avirulent after intracerebral inoculation of adult mice. Furthermore, RV{Delta}G-GP is completely avirulent upon intracerebral inoculation of suckling mice unlike parental RABV vaccine or RV-GP. Analysis of RV{Delta}G-GP in the brain by quantitative PCR, determination of virus titer, and immunohistochemistry indicated greatly restricted virus replication. In summary, our findings indicate that RV-GP retains the attenuation phenotype of the live-attenuated RABV vaccine, and RV{Delta}G-GP would appear to be an even safer alternative for use in wildlife or consideration for human use.

Papaneri, Amy B. [Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD 21702 (United States)] [Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD 21702 (United States); Wirblich, Christoph [Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 (United States)] [Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 (United States); Cann, Jennifer A.; Cooper, Kurt [Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick MD, 21702 (United States)] [Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick MD, 21702 (United States); Jahrling, Peter B. [Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD 21702 (United States) [Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD 21702 (United States); Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick MD, 21702 (United States); Schnell, Matthias J., E-mail: matthias.schnell@jefferson.edu [Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 (United States); Jefferson Vaccine Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 (United States); Blaney, Joseph E., E-mail: jblaney@niaid.nih.gov [Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD 21702 (United States)

2012-12-05T23:59:59.000Z

171

Myxoma Virus Is a Novel Oncolytic Virus with Significant Antitumor Activity against Experimental Human Gliomas  

Science Journals Connector (OSTI)

...myxoma virus [review]. Viral Immunol 2002;15:229-46. 28 Fenner F, Ross J. Myxomatosis. In: Thompson GV, King CM, editors...presence of interferon. Virology 1963;19:294-301. 41 Fenner F, Ratcliffe FN. Myxomatosis. Cambridge (UK): Cambridge...

Xueqing Lun; Wenqing Yang; Tommy Alain; Zhong-Qiao Shi; Huong Muzik; John W. Barrett; Grant McFadden; John Bell; Mark G. Hamilton; Donna L. Senger; Peter A. Forsyth

2005-11-01T23:59:59.000Z

172

Aedes Mosquito Saliva Modulates Rift Valley Fever Virus Pathogenicity  

E-Print Network (OSTI)

's capacity to effectively transfer arboviruses such as the Cache Valley and West Nile viruses. The roleAedes Mosquito Saliva Modulates Rift Valley Fever Virus Pathogenicity Alain Le Coupanec1 , Divya contro^le, Centre IRD de Montpellier, Montpellier, France Abstract Background: Rift Valley fever (RVF

Boyer, Edmond

173

FUTURE THREATS AYCOCK & MAURUSHAT 275VIRUS BULLETIN CONFERENCE SEPTEMBER 2007  

E-Print Network (OSTI)

FUTURE THREATS AYCOCK & MAURUSHAT 275VIRUS BULLETIN CONFERENCE SEPTEMBER 2007 FUTURE THREATS John.maurushat@unsw.edu.au ABSTRACT `Aren't you just giving the virus writers ideas?' Research into future security threats begin to examine how far security research can go in terms of looking at future threats, particularly

Aycock, John

174

Molecular biology study of satellite panicum mosaic virus capsid protein  

E-Print Network (OSTI)

Satellite panicum mosaic virus (SPMV) depends on its helper Panicum mosaic virus (PMV) for replication and movement in host plants. The positive-sense single-stranded genomic RNA of SPMV encodes a 17-kDa capsid protein (CP) to form 16-nm virions...

Qi, Dong

2009-05-15T23:59:59.000Z

175

A distinct lineage of influenza A virus from bats  

Science Journals Connector (OSTI)

...genes for polypeptides NS1 and NS2 on RNA segment 8 of influenza virus...Colinear and interrupted mRNAs code for...each group, excluding NS1, NS2, M1, and M2 as too short for...Generation of influenza A virus NS2 (NEP) mutants with...

Suxiang Tong; Yan Li; Pierre Rivailler; Christina Conrardy; Danilo A. Alvarez Castillo; Li-Mei Chen; Sergio Recuenco; James A. Ellison; Charles T. Davis; Ian A. York; Amy S. Turmelle; David Moran; Shannon Rogers; Mang Shi; Ying Tao; Michael R. Weil; Kevin Tang; Lori A. Rowe; Scott Sammons; Xiyan Xu; Michael Frace; Kim A. Lindblade; Nancy J. Cox; Larry J. Anderson; Charles E. Rupprecht; Ruben O. Donis

2012-01-01T23:59:59.000Z

176

Structural organization of a filamentous influenza A virus  

Science Journals Connector (OSTI)

...influenza A virus nuclear export protein (NEP/NS2) EMBO J 22 : 4646 4655 . 22 Arzt S ( 2001...binding, oligomerisation and binding to NEP (NS2) Virus Res 99 : 115 119 . 24 Harris A Forouhar F Qiu S Sha B Luo M ( 2001...Coun-cil (United Kingdom) under program code U117581334. The authors declare no conflict...

Lesley J. Calder; Sebastian Wasilewski; John A. Berriman; Peter B. Rosenthal

2010-01-01T23:59:59.000Z

177

Molecular Determinants and Dynamics of Hepatitis C Virus Secretion  

E-Print Network (OSTI)

Molecular Determinants and Dynamics of Hepatitis C Virus Secretion Kelly E. Coller, Nicholas S virus (HCV) production involves the assembly of virions on or near the surface of lipid droplets. However, the cellular requirements for and a mechanistic understanding of HCV secretion are incomplete

178

Argonne CNM Highlight: Let a Virus Do All the Work  

NLE Websites -- All DOE Office Websites (Extended Search)

Let a Virus Do All the Work Let a Virus Do All the Work Developing an efficient method to fabricate nanoscale building blocks and organize them into functional architectures is the key to nanoscience and nanotechnology. As a result of millions years of evolution, biological systems can provide spatially defined host systems that can be used as templates for uniform fabrication of structured materials with different length scales. Viruses, in this regard, exemplify an extraordinarily organized nano-architecture: they are complex molecular biosystems in which nucleic acid strands are confined within a nano-size compartment (capsid). This project engages the use of an emptied ligand-displayed phage virus as a template to synthesize magnetic nanoparticles. Benefiting from the phage display technology, the particle generated inside the hollow phage has integrated biorecognition elements with high affinity and specificity for selected target molecules. In addition, the size and shape of the magnetic particles can be highly regulated by molecularly engineering virus capsid.

179

Kinetics of Replication of a Partially Attenuated Virus and of the Challenge Virus during a Three-Year Intersubtype Feline Immunodeficiency Virus Superinfection Experiment in Cats  

Science Journals Connector (OSTI)

...Immunodeficiency Virus Superinfection Experiment in Cats Mauro Pistello Donatella Matteucci Giancarlo Cammarota Paola Mazzetti Simone Giannecchini Daniela Del Mauro Sabina Macchi Lucia Zaccaro Mauro Bendinelli Retrovirus Center and Virology Section...

Mauro Pistello; Donatella Matteucci; Giancarlo Cammarota; Paola Mazzetti; Simone Giannecchini; Daniela Del Mauro; Sabina Macchi; Lucia Zaccaro; Mauro Bendinelli

1999-02-01T23:59:59.000Z

180

Ebola Virus VP40 Late Domains Are Not Essential for Viral Replication in Cell Culture  

Science Journals Connector (OSTI)

...AND REGULATION OF VIRAL GENE EXPRESSION Ebola Virus VP40 Late Domains Are Not Essential...Corporation, Saitama 332-0012, Japan Ebola virus particle formation and budding are...the budding of these viruses, including Ebola virus, it remains unclear as to whether...

Gabriele Neumann; Hideki Ebihara; Ayato Takada; Takeshi Noda; Darwyn Kobasa; Luke D. Jasenosky; Shinji Watanabe; Jin H. Kim; Heinz Feldmann; Yoshihiro Kawaoka

2005-08-01T23:59:59.000Z

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Genetic diversity in chlorella viruses flanking kcv, a gene that encodes a potassium ion channel protein  

E-Print Network (OSTI)

Genetic diversity in chlorella viruses flanking kcv, a gene that encodes a potassium ion channel Received 23 March 2004; accepted 27 May 2004 Abstract The chlorella virus PBCV-1 encodes a 94-amino acid additional chlorella viruses and transcription in two of these viruses, as well as the effect of the three

Graves, Michael V.

182

Molecular and Genetic Evidence for a Virus-Encoded Glycosyltransferase Involved in Protein Glycosylation1  

E-Print Network (OSTI)

capsid protein, Vp54, of chlorella virus PBCV-1 is a glycoprotein that contains either one glycan of 30-encoded glycosyltransferase involved in protein glycosylation. © 2001 Academic Press Key Words: chlorella virus; PBCV-1; Phycodnaviridae; virus glycoprotein; glycosyltransferase. INTRODUCTION Paramecium bursaria chlorella virus-1 (PBCV

Graves, Michael V.

183

Virus Research 140 (2009) 138146 Contents lists available at ScienceDirect  

E-Print Network (OSTI)

homepage: www.elsevier.com/locate/virusres The A312L 5 -UTR of Chlorella virus PBCV-1 is a translational Phycodnaviridae Chlorella viruses A312L gene Arabidopsis thaliana Agrobacterium-mediated transformation a b s t r a c t PBCV-1 (Paramecium bursaria Chlorella virus) is a large double stranded DNA virus

Graves, Michael V.

184

An icosahedral algal virus has a complex unique vertex decorated by a spike  

E-Print Network (OSTI)

bursaria Chlorella virus-1 is an icosahedrally shaped, 1,900-?-diameter virus that infects unicellular cryoelectron microscopy reconstruction Paramecium bursaria Chlorella virus-1 cell entry specialized vertex protein Paramecium bursaria Chlorella virus-1 (PBCV-1) belongs to the genus Chlorovirus

Baker, Timothy S.

185

Nipah virus entry can occur by macropinocytosis  

SciTech Connect

Nipah virus (NiV) is a zoonotic biosafety level 4 paramyxovirus that emerged recently in Asia with high mortality in man. NiV is a member, with Hendra virus (HeV), of the Henipavirus genus in the Paramyxoviridae family. Although NiV entry, like that of other paramyxoviruses, is believed to occur via pH-independent fusion with the host cell's plasma membrane we present evidence that entry can occur by an endocytic pathway. The NiV receptor ephrinB2 has receptor kinase activity and we find that ephrinB2's cytoplasmic domain is required for entry but is dispensable for post-entry viral spread. The mutation of a single tyrosine residue (Y304F) in ephrinB2's cytoplasmic tail abrogates NiV entry. Moreover, our results show that NiV entry is inhibited by constructions and drugs specific for the endocytic pathway of macropinocytosis. Our findings could potentially permit the rapid development of novel low-cost antiviral treatments not only for NiV but also HeV.

Pernet, Olivier; Pohl, Christine; Ainouze, Michelle; Kweder, Hasan [Molecular Basis of Paramyxovirus Entry, INSERM U758 Virologie Humaine IFR 128 BioSciences Gerland-Lyon Sud, 21 Avenue Tony Garnier, 69365 Lyon Cedex 07 (France); Buckland, Robin, E-mail: robin.buckland@inserm.f [Molecular Basis of Paramyxovirus Entry, INSERM U758 Virologie Humaine IFR 128 BioSciences Gerland-Lyon Sud, 21 Avenue Tony Garnier, 69365 Lyon Cedex 07 (France)

2009-12-20T23:59:59.000Z

186

The immune response in turkeys infected with fowl pox viruses and methods of measuring the response  

E-Print Network (OSTI)

10 reported in-vitro neutralization with animal viruses and stated that the serum and virus are freely dissociable. Fenner and Burnet reported that inactivation of fowl pox virus by immune 27 56 serum was rarely effective. Pilchard et al... the results 27 reported open to serious question. Fenner and Burnet was not able to demonstrate hemagglutinins in suspensions of heavily infected CAN with fowl pox virus using techniques similar to 26 those successful with other mammalian pox viruses...

Sarker, Abdul Jalil

2012-06-07T23:59:59.000Z

187

Avoid the Flu Healthy habits and simple actions will help reduce your risk of flu  

E-Print Network (OSTI)

illnesses. Wash your hands. Use soap and water often, especially after coughing or sneezing. Carry alcohol getting sick. Cover your cough. Use a tissue when coughing or sneezing. It can prevent the spread of germs. If you don't have a tissue, cough or sneeze into your arm above your hand. Don't contaminate. Try

Ferrara, Katherine W.

188

Is it a Cold or the Flu? -Know the Difference Signs & Symptoms Cold Flu  

E-Print Network (OSTI)

Rare Usual; high (100.40 F to 1020 F) is typical; lasts 3-4 days Cough Hacking: mild Dry; can become discomfort Mild to moderate; hacking cough Common Treatment Antihistamines Decongestants Advil® (ibuprofen. Avoid close contact with anyone with a cold. Vaccination. Wash your hands. Cover your cough. Stay

Mahon, Bradford Z.

189

Brief Report: Emergence of Zaire Ebola Virus Disease in Guinea  

Science Journals Connector (OSTI)

...gene to test samples obtained from 20 hospitalized patients who were suspected of being infected with a hemorrhagic fever virus. In addition, we performed EBOV-specific real-time RT-PCR assays targeting the glycoprotein (GP) or nucleoprotein (NP) gene. Samples from 15 of 20 patients tested positive... In March 2014, an outbreak of Ebola virus disease associated with a high fatality rate was identified in Guinea, with evidence of ongoing person-to-person transmission. In this update to the preliminary report, the virus is found to be a new strain related to Zaire ebolavirus.

Baize S.; Pannetier D.; Oestereich L.

2014-10-09T23:59:59.000Z

190

Ebola Virus Disease in West Africa Clinical Manifestations and Management  

Science Journals Connector (OSTI)

...testing positive for Ebola virus in blood by polymerase chain reaction (PCR). Although some patients tested positive on PCR within 24 hours after symptom onset, we found that a negative test result could not be relied on to rule out disease until 72 hours after symptoms began. Of the patients who tested... In resource-limited areas, isolation of the sick from the population at large has been the cornerstone of control of Ebola virus disease (EVD) since the virus was discovered in 1976.1 Although this strategy by itself may be effective in controlling small ...

2014-11-05T23:59:59.000Z

191

A Bayesian Dynamic Model for Influenza Surveillance Paola Sebastiani  

E-Print Network (OSTI)

by the increasing number of outbreaks caused by the H5N1 bird-flu strain [10]. Because influenza viruses changeA Bayesian Dynamic Model for Influenza Surveillance Paola Sebastiani Kenneth D Mandl Peter, the growing fear of an influenza pandemic and the recent shortage of flu vaccine highlight the need

Szolovits, Peter

192

Two Years after Pandemic Influenza A/2009/H1N1: What Have We Learned?  

Science Journals Connector (OSTI)

...widely used to predict the spread...conceptual model, prepandemic...community outbreaks, the clinical...infection model system. Antimicrob...monitoring may hide flu threat. Nature...2009 virus outbreak in a school...school-based outbreak of 2009 pandemic...the Xpert Flu A Panel nucleic...J. Mol. Model. 18 : 285-293...

Vincent C. C. Cheng; Kelvin K. W. To; Herman Tse; Ivan F. N. Hung; Kwok-Yung Yuen

2012-04-01T23:59:59.000Z

193

Bayesian modeling to unmask and predict influenza A/H1N1pdm dynamics in London  

Science Journals Connector (OSTI)

...unmask and predict influenza...Centre for Outbreak Analysis...age-structured model into a Bayesian...presence of any flu virus (SI...strength of any model used to predict or assess...class of models. Two separate...the swine-flu pandemic...responses to the outbreak: Results...

Paul J. Birrell; Georgios Ketsetzis; Nigel J. Gay; Ben S. Cooper; Anne M. Presanis; Ross J. Harris; Andr Charlett; Xu-Sheng Zhang; Peter J. White; Richard G. Pebody; Daniela De Angelis

2011-01-01T23:59:59.000Z

194

UHS Health Promotion Office, 110 Anderson Tower, 273-5775 The Monthly InSTALLment November 2007  

E-Print Network (OSTI)

coughing or sneezing, or by touching something with flu viruses on it and then touching your mouth or nose suddenly. Flu symptoms include fever (usually high), headache, extreme tiredness, dry cough, sore throat who are sick. If you are sick, stay home from work and school to help protect others. Cover your cough

Mahon, Bradford Z.

195

Elucidation of the Ebola Virus VP24 Cellular Interactome and Disruption of Virus Biology through Targeted Inhibition of Host-Cell Protein Function  

Science Journals Connector (OSTI)

Elucidation of the Ebola Virus VP24 Cellular Interactome and Disruption of Virus Biology through Targeted Inhibition of Host-Cell Protein Function ... One such virus is Ebola, which has profound consequences for human health and causes viral hemorrhagic fever where case fatality rates can approach 90%. ... The Ebola virus VP24 protein plays a critical role in the evasion of the host immune response and is likely to interact with multiple cellular proteins. ...

Isabel Garca-Dorival; Weining Wu; Stuart Dowall; Stuart Armstrong; Olivier Touzelet; Jonathan Wastling; John N. Barr; David Matthews; Miles Carroll; Roger Hewson; Julian A. Hiscox

2014-08-26T23:59:59.000Z

196

Virus Assemblies as Templates for Nanocircuits  

SciTech Connect

The goals of this project were directed at the identification and characterization of bio-mineralization processes and patterning methods for the development of nano scale materials and structures with novel energy and conductive traits. This project utilized a simple plant virus as a model template to investigate methods to attach and coat metals and other inorganic compounds onto biologically based nanotemplates. Accomplishments include: the development of robust biological nanotemplates with enhanced inorganic coating activities; novel coating strategies that allow for the deposition of a continuous inorganic layer onto a bio-nanotemplate even in the absence of a reducing agent; three-dimensional patterning methods for the assemble of nano-featured high aspect ratio surfaces and the demonstrated use of these surfaces in enhancing battery and energy storage applications. Combined results from this project have significantly advanced our understanding and ability to utilize the unique self-assembly properties of biologically based molecules to produce novel materials at the nanoscale level.

James N Culver; Michael T Harris

2011-08-31T23:59:59.000Z

197

Glycan receptor binding determinants of Influenza A virus hemagglutinin  

E-Print Network (OSTI)

An understanding of the factors involved in the human adaptation of influenza A viruses is critical for various aspects of influenza preparedness, including the development of appropriate surveillance measures, preventive ...

Koh, Xiaoying

2010-01-01T23:59:59.000Z

198

Structure of the Ebola Virus Glycoprotein Bound to an Antibody...  

NLE Websites -- All DOE Office Websites (Extended Search)

Structure of the Ebola Virus Glycoprotein Bound to an Antibody from a Human Survivor Print Ebolavirus, one of two members of the family of filoviruses, causes a severe hemorrhagic...

199

Inactivation of ebola virus with Co(60) irradiation  

SciTech Connect

Ebola virus was inactivated in a log-linear relationship to Co(60) gamma-irradiation dosage with 1.0 log10 pfu/ml reduction in viral titer after 8 min exposure 23,000.

Lupton, H.W.

1980-09-08T23:59:59.000Z

200

Ebola virus disease: an update for anesthesiologists and intensivists  

Science Journals Connector (OSTI)

Ebola virus disease (EVD) is a viral hemorrhagic fever that is highly transmissible and all too often rapidly fatal. Recent outbreaks in West Africa reveal that this infection has the potential to be transmitt...

Duane J. Funk MD; Anand Kumar MD

2014-11-01T23:59:59.000Z

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
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201

An Analysis of some Necrotic Virus Diseases of the Potato  

Science Journals Connector (OSTI)

1 June 1932 research-article An Analysis of some Necrotic Virus Diseases of the Potato Redcliffe N. Salaman F. C. Bawden The Royal Society is collaborating with JSTOR to digitize, preserve, and extend access to...

1932-01-01T23:59:59.000Z

202

Studies on a Virus Causing Foliar Necrosis of the Potato  

Science Journals Connector (OSTI)

1 December 1934 research-article Studies on a Virus Causing Foliar Necrosis of the Potato F. C. Bawden The Royal Society is collaborating with JSTOR to digitize, preserve, and extend access to Proceedings of the Royal...

1934-01-01T23:59:59.000Z

203

Host/virus interactions in the marine cyanobacterium prochlorococcus  

E-Print Network (OSTI)

Bacterial viruses shape the diversity, metabolic function, and community dynamics of their microbial hosts. As microbes drive many major biogeochemical cycles, viral infection is therefore a phenomenon of global significance. ...

Frois-Moniz, Katya

2014-01-01T23:59:59.000Z

204

Structure of the Tetramerization Domain of Measles Virus Phosphoprotein  

Science Journals Connector (OSTI)

...state of the Sendai virus P protein. Virology 266 :99-109...structural model for unfolded proteins from residual dipolar couplings...generation of explicit ensemble descriptions of intrinsically disordered proteins and their associated experimental...

Guillaume Communie; Thibaut Crpin; Damien Maurin; Malene Ringkjbing Jensen; Martin Blackledge; Rob W. H. Ruigrok

2013-04-10T23:59:59.000Z

205

Whole-Blood Hepatitis C Virus RNA Extraction Methods  

Science Journals Connector (OSTI)

...peripheral blood mononuclear cells. . W. N. Schmidt P. Wu J. Cederna F. A. Mitros D. R. LaBrecque J. T. Stapleton Surreptitious hepatitis C virus (HCV) infection detected in the majority of patients with cryptogenic chronic hepatitis and negative...

Warren Schmidt; Jack T. Stapleton

2001-10-01T23:59:59.000Z

206

Nanomachines: How Viruses Work, and How We Can Stop Them  

ScienceCinema (OSTI)

Nature's Nasty Nanomachines: How Viruses Work, and How We Can Stop Them. Carolyn Bertozzi, director of Berkeley Lab's Molecular Foundry, discusses this topic at a Feb. 21, 2009 Nano*High talk.

Carolyn Bertozzi

2010-01-08T23:59:59.000Z

207

Recombinant protein production using the Semliki Forest Virus expression system  

Science Journals Connector (OSTI)

We report here the successful scale up of transient recombinant protein expression to litre scale using Semliki Forest Virus System. The expression of bacterial ?-galactosidase was initially compared in BHK an...

H.D. Blasey; K. Lundstrm; S. Tate; A.R. Bernard

208

Virulence evolution in a virus obeys a trade off  

Science Journals Connector (OSTI)

...order of magnitude improvement in host survival (Fenner & Ratcli e 1965; Fenner & Myers 1978). However, in the last two decades...biology. Epidemiol. Infect. Dis. 2, 245^256. Fenner, F. & Myers, K. 1978 Myxoma virus and myxomatosis...

1999-01-01T23:59:59.000Z

209

The Amino Terminus of Herpes Simplex Virus Type 1 Glycoprotein K (gK) Modulates gB-Mediated Virus-Induced Cell Fusion and Virion Egress  

Science Journals Connector (OSTI)

...extensive virus-induced cell fusion of all cell types, unlike gB syncytial mutations...1982. Herpes simplex virus type 1 cell fusion occurs in the presence of...2007. Herpes simplex virus type 1 mediates fusion through a hemifusion intermediate...

Vladimir N. Chouljenko; Arun V. Iyer; Sona Chowdhury; Dmitry V. Chouljenko; Konstantin G. Kousoulas

2009-09-30T23:59:59.000Z

210

High molecular weight polysaccharide that binds and inhibits virus  

DOE Patents (OSTI)

This invention provides a high molecular weight polysaccharide capable of binding to and inhibiting virus and related pharmaceutical formulations and methods on inhibiting viral infectivity and/or pathogenicity, as well as immunogenic compositions. The invention further methods of inhibiting the growth of cancer cells and of ameliorating a symptom of aging. Additionally, the invention provides methods of detecting and/or quantifying and/or isolating viruses.

Konowalchuk, Thomas W

2014-01-14T23:59:59.000Z

211

Icosadeltahedral geometry of fullerenes, viruses and geodesic domes  

E-Print Network (OSTI)

I discuss the symmetry of fullerenes, viruses and geodesic domes within a unified framework of icosadeltahedral representation of these objects. The icosadeltahedral symmetry is explained in details by examination of all of these structures. Using Euler's theorem on polyhedra, it is shown how to calculate the number of vertices, edges, and faces in domes, and number of atoms, bonds and pentagonal and hexagonal rings in fullerenes. Caspar-Klug classification of viruses is elaborated as a specific case of icosadeltahedral geometry.

Antonio Siber

2007-11-22T23:59:59.000Z

212

Interim Report on SNP analysis and forensic microarray probe design for South American hemorrhagic fever viruses, tick-borne encephalitis virus, henipaviruses, Old World Arenaviruses, filoviruses, Crimean-Congo hemorrhagic fever viruses, Rift Valley fever  

SciTech Connect

The goal of this project is to develop forensic genotyping assays for select agent viruses, enhancing the current capabilities for the viral bioforensics and law enforcement community. We used a multipronged approach combining bioinformatics analysis, PCR-enriched samples, microarrays and TaqMan assays to develop high resolution and cost effective genotyping methods for strain level forensic discrimination of viruses. We have leveraged substantial experience and efficiency gained through year 1 on software development, SNP discovery, TaqMan signature design and phylogenetic signature mapping to scale up the development of forensics signatures in year 2. In this report, we have summarized the whole genome wide SNP analysis and microarray probe design for forensics characterization of South American hemorrhagic fever viruses, tick-borne encephalitis viruses and henipaviruses, Old World Arenaviruses, filoviruses, Crimean-Congo hemorrhagic fever virus, Rift Valley fever virus and Japanese encephalitis virus.

Jaing, C; Gardner, S

2012-06-05T23:59:59.000Z

213

Inactivation of Lassa, Marburg, and Ebola viruses by gamma irradiation  

SciTech Connect

Because of the cumbersome conditions experienced in a maximum containment laboratory, methods for inactivating highly pathogenic viruses were investigated. The infectivity of Lassa, Marburg, and Ebola viruses was inactivated without altering the immunological activity after radiation with /sup 60/CO gamma rays. At 4 degrees C, Lassa virus was the most difficult to inactivate with a rate of 5.3 X 10(-6) log 50% tissue culture infective dose per rad of /sup 60/CO radiation, as compared with 6.8 X 10(-6) log 50% tissue culture infective dose per rad for Ebola virus and 8.4 X 10(-6) log 50% tissue culture infective dose per rad for Marburg virus. Experimental inactivation curves, as well as curves giving the total radiation needed to inactivate a given concentration of any of the three viruses, are presented. The authors found this method of inactivation to be superior to UV light or beta-propiolactone inactivation and now routinely use it for preparation of material for protein-chemistry studies or for preparation of immunological reagents.

Elliott, L.H.; McCormick, J.B.; Johnson, K.M.

1982-10-01T23:59:59.000Z

214

Inactivation of Lassa, Marburg, and Ebola viruses by gamma irradiation  

SciTech Connect

Because of the cumbersome conditions experienced in a maximum containment laboratory, methods for inactivating highly pathogenic viruses were investigated. The infectivity of Lassa, Marburg, and Ebola viruses was inactivated without altering the immunological activity after radiation with /sup 60/Co gamma rays. At 4 degrees C, Lassa virus was the most difficult to inactivate with a rate of 5.3 X 10(-6) log 50% tissue culture infective dose per rad of /sup 60/Co radiation, as compared with 6.8 X 10(-6) log 50% tissue culture infective dose per rad for Ebola virus and 8.4 X 10(-6) log 50% tissue culture infective dose per rad for Marburg virus. Experimental inactivation curves, as well as curves giving the total radiation needed to inactivate a given concentration of any of the three viruses, are presented. We found this method of inactivation to be superior to UV light or beta-propiolactone inactivation and now routinely use it for preparation of material for protein-chemistry studies or for preparation of immunological reagents.

Elliott, L.H.; McCormick, J.B.; Johnson, K.M.

1982-10-01T23:59:59.000Z

215

A Nuclear Export Signal in the Matrix Protein of Influenza A Virus Is Required for Efficient Virus Replication  

Science Journals Connector (OSTI)

...efficiency of the nuclear export of M1...National Basic Research Program (973) of China...Technologies Research and Development Program of China (grant...the Innovative Research Group of the...influenza A virus nuclear export protein...

Shuai Cao; Xiaoling Liu; Maorong Yu; Jing Li; Xiaojuan Jia; Yuhai Bi; Lei Sun; George F. Gao; Wenjun Liu

2012-02-15T23:59:59.000Z

216

Lessons learned and concepts formed from study of the pathogenesis of the two negative-strand viruses lymphocytic choriomeningitis and influenza  

Science Journals Connector (OSTI)

...LCMV in a murine model can be or have been...strength of the LCMV model rests on three unique foundations...storm-related deaths during outbreaks of the H5N1 bird flu and the 2009 H1N1 influenza...infection in the mouse model. S1P is a signaling...provide factors to predict who will succumb...

Michael B. A. Oldstone

2013-01-01T23:59:59.000Z

217

Susceptibility of Highly Pathogenic H5N1 Influenza Viruses to the Neuraminidase Inhibitor Oseltamivir Differs In Vitro and in a Mouse Model  

Science Journals Connector (OSTI)

...the proportional hazards model. e Loss or gain of weight...R. 1972. Regression models and life-tables. J...Kawaoka. 2005. Avian flu: isolation of drug-resistant...in vitro and in a mouse model. | While the neuraminidase...whether in vitro testing can predict the in vivo effectiveness...

Elena A. Govorkova; Natalia A. Ilyushina; Jennifer L. McClaren; Tri S. P. Naipospos; Bounlom Douangngeun; Robert G. Webster

2009-04-06T23:59:59.000Z

218

Putative amino acid determinants of the emergence of the 2009 influenza A (H1N1) virus in the human population  

Science Journals Connector (OSTI)

...complexities of swine flu H1N1 gene sequences of 2009...isolated during an influenza outbreak at Fort Dix, New Jersey . J Infect Dis 136...DBA/2 mouse influenza model . J Virol 84 : 7662 7667...selected. In order to predict the label of a given...that can then be used to predict which strain a certain...

Daphna Meroz; Sun-Woo Yoon; Mariette F. Ducatez; Thomas P. Fabrizio; Richard J. Webby; Tomer Hertz; Nir Ben-Tal

2011-01-01T23:59:59.000Z

219

Environmental assessment of curly top virus control in California. [Curly Top Virus  

SciTech Connect

Curly top is a viral disease of sugarbeets, tomatoes, melons, peppers, beans, cucumbers, squash, pumpkins, spinach, vineseed and other commercially important crops, including ornamentals. Curly top not only infects commercial crops, but at times devastates backyard vegetable and flower gardens. The only known vector of curly top is Circulifer tenellus, commonly known as the beet leafhopper. Control of the beet leafhopper may take place at various locations throughout the San Joaquin Valley, Salinas Valley, Cuyama Valley, Antelope Valley of northern Los Angeles County, Riverside County and the Imperial Valley (See Maps in Appendix E''), including portions of Merced, Fresno, Kings. Kern, San Luis Obispo, Monterey, San Benito, Santa Barbara, Los Angeles, Riverside and Imperial Counties. The size of the control program is totally dependent on the location, size, nd distribution of the beet leafhopper population. In a year with a low population, only 80,000 acres in western Fresno, Kings, and Kern Counties may require treatment. In a drought year, the treatment required may increase to more than 200,000 acres and include some inter-coastal valleys of Monterey, San Luis Obispo and Santa Barbara Counties. Not all areas require treatment on an annual basis and at no time is the entire area subject to blanket treatment. The Curly Top Virus Control Program (CTVCP) was instrumental in supporting research which developed an antisera allowing the use of Enzyme-Linked Immunosorbent Assay to determine the presence, on a percentage basis, of curly top virus. Thus, the amount of virus found in a given area lends weight to treatment priorities.

Not Available

1991-03-15T23:59:59.000Z

220

Ebola virus infection inversely correlates with the overall expression levels of promyelocytic leukaemia (PML) protein in cultured cells  

Science Journals Connector (OSTI)

Ebola virus causes severe, often fatal hemorrhagic fever ... the PML body. The possible interaction between Ebola virus and the PML bodies has not...

Asa Szekely Bjrndal; Laszlo Szekely; Fredrik Elgh

2003-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Analyse phylogntique des souches du virus de la fivre hmorragique Ebola et mise en vidence de souches atypiques.  

E-Print Network (OSTI)

??La fivre hmorragique virus Ebola (FHVE) est due un virus ARN non segment de polarit ngative de lordre des Monongavirales. Il compose (more)

Wittmann, Tatiana

2007-01-01T23:59:59.000Z

222

E-Print Network 3.0 - avian influenza epidemics Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

occurs when a new Summary: What is Pandemic Influenza? A pandemic is a global disease outbreak. A flu pandemic occurs when... a new influenza virus emerges for which people...

223

Science Highlights 2006  

NLE Websites -- All DOE Office Websites (Extended Search)

6 Photo: The x-ray structure of the effector domain of influenza virus NS1 protein. A Bird Flu Protein Link to Virulence DECEMBER 12, 2006New information obtained at an APS...

224

Structural Basis of Pre-existing Immunity to the 2009 H1N1 Pandemic  

NLE Websites -- All DOE Office Websites (Extended Search)

Structural Basis of Pre-existing Immunity to the 2009 Structural Basis of Pre-existing Immunity to the 2009 H1N1 Pandemic Influenza Virus The emergence of the 2009 H1N1 influenza pandemic, also known as the "swine flu", marks the first human flu pandemic in 40 years and has caused significant human infection and mortality globally (1). The emergence of the 2009 H1N1 flu marks the first time that an influenza pandemic was triggered by a virus carrying the same hemagglutinin (HA) subtype as circulating seasonal strains. In contrast, all prior pandemics were caused by the rise of a novel influenza strain with a different hemagglutinin subtype. And unlike seasonal flu that usually affects the elderly most severely, swine flu has been primarily targeting people under the age of 65, implying some age-related pre-existing immunity (2, 3).

225

Ebola virus RNA editing:Characterization of the mechanism and gene products.  

E-Print Network (OSTI)

??Ebola virus (EBOV) is an enveloped, negative-sense single-stranded RNA virus that causes severe hemorrhagic fever in humans and nonhuman primates. The EBOV glycoprotein (GP) gene (more)

Mehedi, Masfique

2012-01-01T23:59:59.000Z

226

Outbreaks of Ebola virus disease in Africa: the beginnings of a tragic saga  

Science Journals Connector (OSTI)

The tremendous outbreak of Ebola virus disease occurring in West Africa since ... review aims to describe the 27 manifestations of Ebola virus that arose after its discovery in ... an update on research on the ec...

2014-10-01T23:59:59.000Z

227

Involvement of ATP synthase ? subunit in chikungunya virus entry into insect cells  

Science Journals Connector (OSTI)

Chikungunya virus (CHIKV), the virus responsible for the disease chikungunya fever in humans, is transmitted by Aedes mosquitoes. While significant progress has been made in understanding the process by which CHI...

Chanida Fongsaran; Krit Jirakanwisal; Atichat Kuadkitkan

2014-12-01T23:59:59.000Z

228

The Capsid Proteins of a Large, Icosahedral dsDNA Virus  

E-Print Network (OSTI)

Paramecium bursaria chlorella virus 1 Vp54 MCP. This model was fitted into the cryoEM density for eachEM, cryoelectron microscopy; MCP, major capsid protein; PBCV-1, Paramecium bursaria chlorella virus type 1; PpV01

Baker, Timothy S.

229

E-Print Network 3.0 - af hepatitis c-virus Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

C Virus 1a and 1b: A Phylodynamic and Phylogeographic Analysis... , Paraskevis D, Ho SYW, Shapiro B, et al. (2009) The Global Spread of Hepatitis C Virus 1a and 1b... exist....

230

STUDIES OF THE MAHONEY (TYPE II BRUNHILDE) STRAIN OF POLIOMYELITIS VIRUS IN THE SYRIAN HAMSTER  

Science Journals Connector (OSTI)

...SYRIAN HAMSTER Reginald L. Reagan Sing Chen Chang A. L. Brueckner Virus Laboratory, Live Stock Sanitary Service, University...HAMSTER REGINALD L. REAGAN, SING CHEN CHANG, AND A. L. BRUECKNER Virus Laboratory, Live Stock Sanitary Service, University...

Reginald L. Reagan; Sing Chen Chang; A. L. Brueckner

1955-04-01T23:59:59.000Z

231

Datasets: Phylogenetic assessment of filoviruses: how many lineages of Marburg virus?  

E-Print Network (OSTI)

Filoviruses have to date been considered as consisting of one diverse genus (Ebola viruses) and one undifferentiated genus (Marburg virus). We reconsider this idea by means of detailed phylogenetic analyses of sequence ...

Peterson, A. Townsend; Holder, Mark T.

2012-06-08T23:59:59.000Z

232

E-Print Network 3.0 - abutilon mosaic virus Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

mosaic virus reveals prokaryotic as well as eukaryotic features. Virology 178... of Potato yellow mosaic virus from the Caribbean Brief Report C. Urbino1, J. E. Polston2, C. P....

233

E-Print Network 3.0 - adenovirus influenza virus Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

17 VII. Related Products 18 List of Figures Figure 1. Principle of Adeno-X Virus... as effective (Table I). A chromatographic method The Adeno-X Virus Purification Kit lets...

234

Genetic variability of herpes simplex virus: development of a pathogenic variant during passaging of a nonpathogenic herpes simplex virus type 1 virus strain in mouse brain.  

Science Journals Connector (OSTI)

...All 15 clones picked from intracerebral virus were like- wise i.p. pathogenic. A similar selection of a pathogenic variant...31-38. 28. Zisman, B., M. S. Hirsch, and A. C. Alison. 1970. Selective effects of anti-macrophage serum, silica...

H C Kaerner; C H Schrder; A Ott-Hartmann; G Kmel; H Kirchner

1983-04-01T23:59:59.000Z

235

Cytotoxic Tcell abundance and virus load in human immunodeficiency virus type 1 and human Tcell leukaemia virus type 1  

Science Journals Connector (OSTI)

...important determinant of viral load and, thus, explain the di erent...correlation between CTLs and virus load and its implications for the...correct inter- pretation of the data. A chronic in ammatory disease...with a high HTLV-1 proviral load (Nagai et al. 1998). We have...

2001-01-01T23:59:59.000Z

236

Oxylipin Biosynthesis Genes Positively Regulate Programmed Cell Death during Compatible Infections with the Synergistic Pair Potato Virus X-Potato Virus Y and Tomato Spotted Wilt Virus  

Science Journals Connector (OSTI)

...25 :709-723. 39. Liu, Y , M Schiff, and SP Dinesh-Kumar. 2004. Involvement of MEK1 MAPKK, NTF6 MAPK, WRKY...1165-1175. 65. Soosaar, JL , TM Burch-Smith, and SP Dinesh-Kumar. 2005. Mechanisms of plant resistance to viruses...

Alberto Garca-Marcos; Remedios Pacheco; Aranzazu Manzano; Emmanuel Aguilar; Francisco Tenllado

2013-03-13T23:59:59.000Z

237

E-Print Network 3.0 - anti-influenza virus activity Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

Computer Technologies and Information Sciences 47 Introduction: Molecular Bio-Hacking Department of Bioengineering Summary: -evolving Computer worm: Biological virus: ...

238

E-Print Network 3.0 - acquired immunodeficiency virus Sample...  

NLE Websites -- All DOE Office Websites (Extended Search)

1 replication. Science... immunodeficiency virus. Proc Natl Acad Sci ... Source: Utrecht, Universiteit - Departement Biologie, Theoretical BiologyBioinformatics Group...

239

Ebola Virus Glycoproteins Induce Global Surface Protein Down-Modulation and Loss of Cell Adherence  

Science Journals Connector (OSTI)

ARTICLE PATHOGENESIS AND IMMUNITY Ebola Virus Glycoproteins Induce Global Surface...Philadelphia, Pennsylvania 19104-6076 The Ebola virus envelope glycoprotein (GP) derived...rounding and detachment in 293T cells, Ebola virus GP did not cause an increase in cell...

Graham Simmons; Rouven J. Wool-Lewis; Frdric Baribaud; Robert C. Netter; Paul Bates

2002-03-01T23:59:59.000Z

240

Adsorbing Viruses onto TEM Grids Jennifer Brum, Tucson Marine Phage Lab  

E-Print Network (OSTI)

1 Adsorbing Viruses onto TEM Grids Jennifer Brum, Tucson Marine Phage Lab October, 2011 Purpose: This protocol describes how to adsorb viruses onto TEM (transmission electron microscopy) grids. The sample is allowed to sit on a hydrophilic grid and viruses adsorb onto the surface of the grid. This technique

Sullivan, Matthew B.

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

The Outbreak of West Nile Virus Infection in the New York City Area in 1999  

Science Journals Connector (OSTI)

...outbreaks among both birds and humans. West Nile virus belongs to the Japanese encephalitis serogroup of flaviviruses that includes the St. Louis encephalitis, Kunjin, and Murray Valley encephalitis viruses, each of which is antigenically closely related to West Nile virus. This report summarizes the... The attack rate increased sharply with age, and seven patients died.

Nash D.; Mostashari F.; Fine A.

2001-06-14T23:59:59.000Z

242

Characterization of a -1,3-Glucanase Encoded by Chlorella Virus PBCV-11 Liangwu Sun,*,2  

E-Print Network (OSTI)

Characterization of a -1,3-Glucanase Encoded by Chlorella Virus PBCV-11 Liangwu Sun,*,2 James R of the 330-kb chlorella virus PBCV-1 genome revealed an open-reading frame, A94L, that encodes a protein.i. postinfection, respectively, indicating that a94l is an early gene. Twenty-seven of 42 chlorella viruses

Graves, Michael V.

243

Final report [FASEB Summer Research Conference ''Virus Assembly''--agenda and attendee list  

SciTech Connect

The conference brought together researchers working on virus structure and virus assembly in diverse systems. Information was integrated from many viral systems, including plant bacterial and eukaryotic viruses, and many techniques such as biophysical approaches of x-ray diffraction, electron microscopy and spectroscopy, along with molecular biological and molecular genetic analysis.

Feiss, Michael

2001-01-31T23:59:59.000Z

244

Subgenomic mRNA in OK10 Defective Leukemia Virus-Transformed Cells  

Science Journals Connector (OSTI)

...Viruses Subgenomic mRNA in OK10 Defective Leukemia Virus-Transformed...Helsinki 29, Finland OK10, a defective leukemia virus, is produced...transcriptase assay. OK10 defective viral particles were purified...transcriptase assay was then car- ried out as follows: purified...

S. Saule; A. Sergeant; G. Torpier; M. B. Raes; S. Pfeifer; D. Stehelin

1982-04-01T23:59:59.000Z

245

Rubella Virus Capsid Associates with Host Cell Protein p32 and Localizes to Mitochondria  

Science Journals Connector (OSTI)

...glycoprotein domains in assembly of virus-like particles. . B. Ghebrehiwet B. L. Lim E. I...C on encapsidation of RNA within core particles of hepatitis B virus. . A. R. Krainer...Bowden Localization of rubella virus core particles in vero cells. . J. R. Lingappa R...

Martin D. Beatch; Tom C. Hobman

2000-06-01T23:59:59.000Z

246

Efficient expression of influenza virus NS1 nonstructural proteins in Escherichia coli  

Science Journals Connector (OSTI)

...influenza A virus genome codes for two nonstructural proteins, NS1 and NS2, for which the functions...influenza A virus genome codes for two nonstructural proteins, NS1 and NS2, for which the functions...influenza A virus genome codes for two nonstructural proteins, NS1 and NS2, for which the functions...

J F Young; U Desselberger; P Palese; B Ferguson; A R Shatzman; M Rosenberg

1983-01-01T23:59:59.000Z

247

Influenza B and C Virus NEP (NS2) Proteins Possess Nuclear Export Activities  

Science Journals Connector (OSTI)

...coding for the NS1 and NS2 proteins. . D. J. Briedis...B virus RNA segment 8 codes for two nonstructural...Influenza A virus NEP (NS2 protein) downregulates...Influenza C virus RNA 7 codes for a nonstructural protein...second NS gene product (NS2 protein). . S. Nakielny...

Jason Paragas; Julie Talon; Robert E. O'Neill; D. Karl Anderson; Adolfo Garc??a-Sastre; Peter Palese

2001-08-01T23:59:59.000Z

248

Accepted Manuscript High occurrence of Hepatitis E virus in samples from wastewater treatment plants in  

E-Print Network (OSTI)

Accepted Manuscript High occurrence of Hepatitis E virus in samples from wastewater treatment-Bianchi, D., Oppliger, A., High occurrence of Hepatitis E virus in samples from wastewater treatment plants MANUSCRIPT Highlights Hepatitis E virus (HEV) was searched in raw and treated wastewater in Switzerland

Alvarez, Nadir

249

Alfalfa mosaic virus replicase proteins, P1 and P2, localize to the tonoplast in the presence of virus RNA  

SciTech Connect

To identify the virus components important for assembly of the Alfalfa mosaic virus replicase complex, we used live cell imaging of Arabidopsis thaliana protoplasts that expressed various virus cDNAs encoding native and GFP-fusion proteins of P1 and P2 replicase proteins and full-length virus RNAs. Expression of P1-GFP alone resulted in fluorescent vesicle-like bodies in the cytoplasm that colocalized with FM4-64, an endocytic marker, and RFP-AtVSR2, RabF2a/Rha1-mCherry, and RabF2b/Ara7-mCherry, all of which localize to multivesicular bodies (MVBs), which are also called prevacuolar compartments, that mediate traffic to the lytic vacuole. GFP-P2 was driven from the cytosol to MVBs when expressed with P1 indicating that P1 recruited GFP-P2. P1-GFP localized on the tonoplast, which surrounds the vacuole, in the presence of infectious virus RNA, replication competent RNA2, or P2 and replication competent RNA1 or RNA3. This suggests that a functional replication complex containing P1, P2, and a full-length AMV RNA assembles on MVBs to traffic to the tonoplast.

Ibrahim, Amr [Department of Botany and Plant Pathology, Purdue University, West Lafayette, IN 47907 (United States) [Department of Botany and Plant Pathology, Purdue University, West Lafayette, IN 47907 (United States); Present address: Genomics Facility, Agricultural Genetic Engineering Research Institute, Agricultural Research Center, Giza 12619 (Egypt); Hutchens, Heather M. [Department of Botany and Plant Pathology, Purdue University, West Lafayette, IN 47907 (United States)] [Department of Botany and Plant Pathology, Purdue University, West Lafayette, IN 47907 (United States); Howard Berg, R. [Integrated Microscopy Facility, Donald Danforth Plant Science Center, Saint Louis, MO 63132 (United States)] [Integrated Microscopy Facility, Donald Danforth Plant Science Center, Saint Louis, MO 63132 (United States); Sue Loesch-Fries, L., E-mail: loeschfr@purdue.edu [Department of Botany and Plant Pathology, Purdue University, West Lafayette, IN 47907 (United States)

2012-11-25T23:59:59.000Z

250

How a Virus Prepares to Infect Cells | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

Magnetic Switching under Pressure Magnetic Switching under Pressure Revealing the Secrets of Chemical Bath Deposition DNA Repair Protein Caught in the Act of Molecular Theft Velcro for Nanoparticles A Molecular Fossil Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed How a Virus Prepares to Infect Cells DECEMBER 8, 2010 Bookmark and Share This diagram depicts how the changing arrangement of proteins in a key structure enables viruses to invade and fuse with host cells. (Courtesy Purdue University Department of Biological Sciences image/Long Li) The atomic-scale arrangement of proteins in a structure that enables a virus to invade and fuse with host cells, showing precisely how the

251

The First Case of Ebola Virus Disease Acquired outside Africa  

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...assistant has subsequently recovered and was discharged from the hospital on November 5. Signs of infection have not developed in any of the eight health care workers who were in contact with this nurse assistant, and all have passed the 21-day incubation period after exposure. No other secondary cases... To the Editor: The current epidemic of Ebola virus disease (EVD) remains essentially confined to West Africa.1 We present a case of transmission of the virus associated with the care of a patient who was transported from Sierra Leone to Spain on ...

2014-11-19T23:59:59.000Z

252

RNA segment 5 of broadhaven virus, a tick-borne orbivirus, shows sequence homology with segment 5 of bluetongue virus  

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The sequence of Broadhaven (BIRD) virus segment 5, the major genetic determinant of serotype, is 1658 nucleotides in length and contains a single open reading frame (ORF) having the coding capacity for a protein of Mr 52.5K. Comparison of the ORF of segment 5 of BIRD virus with published sequences of bluetongue virus (BTV) revealed 30% nucleotide homology and 31 % amino acid homology with the protein encoded by segment 5 of BTV serotype 10. Significant homology was not shown with segment 2 of BTV, the major genetic determinant of the BTV serotype. The sequences at the 3? and 5? ends determined for BIRD segment 5 were similar to the respective 3? and 5? regions of BTV. The sequence data provide evidence of an evolutionary relationship between two ecologically distinct groups of orbiviruses and demonstrate changes that have occurred in the functions of genetically related genomic segments.

Stephen R. Moss; Akio Fukusho; Patricia A. Nuttall

1990-01-01T23:59:59.000Z

253

Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Protects Nonhuman Primates from Intramuscular and Aerosol Challenge with Ebolavirus  

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...Reston virus (RESTV), Sudan virus (SUDV), Tai Forest...Sciences, Penzberg, Germany) thermal cycler. Fluorescence was measured...expression of Ebola virus and Sudan virus GP. BHK cells were infected...report the protective efficacy of Sudan ebolavirus (SUDV) and Zaire...

Andrew S. Herbert; Ana I. Kuehne; James F. Barth; Ramon A. Ortiz; Donald K. Nichols; Samantha E. Zak; Spencer W. Stonier; Majidat A. Muhammad; Russell R. Bakken; Laura I. Prugar; Gene G. Olinger; Jennifer L. Groebner; John S. Lee; William D. Pratt; Max Custer; Kurt I. Kamrud; Jonathan F. Smith; Mary Kate Hart; John M. Dye

2013-02-13T23:59:59.000Z

254

Vorticity banding in rodlike virus suspensions Kyongok Kang,1  

E-Print Network (OSTI)

Vorticity banding in rodlike virus suspensions Kyongok Kang,1 M. P. Lettinga,1 Z. Dogic,2 and Jan K. G. Dhont1 1 Institute für Festkörper Forschung (IFF), Weiche Materie, Forschungszentrum Jülich, D

Fraden, Seth

255

High-Throughput Detection of West Nile Virus RNA  

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...increased the amplification efficiency. However, we found...increase the amplification efficiency in assays targeting...Forster Zwischenmolekulare energy-wanderung und fluoreszenz...France . J. R. Lakowicz Energy transfer . R. S. Lanciotti...Isolation from human sera in Egypt of a virus apparently...

Pei-Yong Shi; Elizabeth B. Kauffman; Ping Ren; Andy Felton; Jennifer H. Tai; Alan P. Dupuis II; Susan A. Jones; Kiet A. Ngo; David C. Nicholas; Joseph Maffei; Gregory D. Ebel; Kristen A. Bernard; Laura D. Kramer

2001-04-01T23:59:59.000Z

256

The epidemiology of human immunodeficiency virus in South Africa  

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...CH-1211, Switzerland We review the epidemiology of human immunodeficiency...done in this regard in order to plan, coordinate and evaluate an...virus in South Africa. | We review the epidemiology of human immunodeficiency...done in this regard in order to plan, coordinate and evaluate an...

2001-01-01T23:59:59.000Z

257

STUDIES OF DENGUE FEVER VIRUS BY ELECTRON MICROSCOPY  

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...MICROSCOPY Reginald L. Reagan A. L. Brueckner Live Stock Sanitary Service Laboratory...MICROSCOPY REGINALD L. REAGAN AND A. L. BRUECKNER Live Stock Sanitary Service Laboratory...material 233 REGINALD L. REAGAN AND A. L. BRUECKNER Figure 1. Dengue fever virus (mouse...

Reginald L. Reagan; A. L. Brueckner

1952-08-01T23:59:59.000Z

258

Genome Scale Patterns of Recombination between Coinfecting Vaccinia Viruses  

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...recombination could also produce hybrids between related poxviruses...discovery of another natural hybrid between rabbit fibroma and...Cancer Foundation and by an infrastructure award from the Canada Foundation...and KR Dumbell. 1964. Hybrids derived from the viruses of...

Li Qin; David H. Evans

2014-02-26T23:59:59.000Z

259

Antibody-mediated neutralization of virus is abrogated by mycoplasma.  

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...uninfected), whereas the same virus stock showed no significant differ- ence when neutralized by the guinea pig anti- VSVIdi.. sexo,, serum. The latter serum was not as effective in neutralization as the sheep immunoglobulin since a low, residual, non-neu...

C Dickson; J Elkington; A Hales; R Weiss

1980-06-01T23:59:59.000Z

260

Origin of HTLV-I virus in Japan  

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... SIR-If the human T lymphotropic virus I (HTLV-I) was brought to Japan from Africa by the Portuguese in the sixteenth century as in the proposal of Gallo ... India, Ceylon and Malacca, where the Portuguese constructed their bases long before arriving in Japan. Yet, recently, we tested 90 sera in Bombay for HTLV-I antibody and ...

HIROKUNI TAGUCHI

1986-10-30T23:59:59.000Z

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
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261

Polymerase chain reaction: detection of varicella-zoster virus.  

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...detection of varicella-zoster virus. T Fenner A Kropec J Hubner Polymerase chain reaction...viral diagnostic tool. REFERENCES 1. Fenner, T., J. Garweg, F. Hufert, M...Clin. Microbiol. 29:76-79. Thomas Fenner Andrea Kropec Johannes Hubner Department...

T Fenner; A Kropec; J Hbner

1993-02-01T23:59:59.000Z

262

RESPONSE OF MICE TO ECTROMELIA AND VACCINIA VIRUSES  

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...two viruses The careful experiments of Fenner (9, 10) (3-5). Sera of mice recovered...Diagrammatic description of mouse pox (after Fenner (9)) epizootics of mouse pox in the...intestine was so fre- In this connection, Fenner (7) has noted that the quently observed...

Bernard A. Briody

1959-06-01T23:59:59.000Z

263

2005 Nature Publishing Group Photosynthesis genes in marine viruses yield  

E-Print Network (OSTI)

© 2005 Nature Publishing Group Photosynthesis genes in marine viruses yield proteins during host­6 probably influences the genetic and functional diversity of both. For example, photosynthesis genes period. We also show that the expression of host photosynthesis genes declines over the course

Church, George M.

264

Conformational Changes in the Hepatitis B Virus Core Protein Are Consistent with a Role for Allostery in Virus Assembly  

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...B virus (HBV) core protein dimer, which can spontaneously...differences between core protein dimer and capsid conformations...is more accurately an ensemble of conformations. Simulations...would explain how capsid proteins avoid packaging the...which appears to be disordered based on image reconstructions...

Charles Packianathan; Sarah P. Katen; Charles E. Dann III; Adam Zlotnick

2009-11-25T23:59:59.000Z

265

Tobacco Mosaic Virus Replicase-Auxin/Indole Acetic Acid Protein Interactions: Reprogramming the Auxin Response Pathway To Enhance Virus Infection  

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...pTRV1 and pTRV2, were kindly provided by S. P. Dinesh-Kumar, Yale University (26). The LeIAA26 ORF was PCR...377-398. 26 Liu, Y., M. Schiff, and S. P. Dinesh-Kumar. 2002. Virus-induced gene silencing in tomato...

Meenu S. Padmanabhan; Sabrina R. Kramer; Xiao Wang; James N. Culver

2007-12-19T23:59:59.000Z

266

Contribution of Endocytic Motifs in the Cytoplasmic Tail of Herpes Simplex Virus Type 1 Glycoprotein B to Virus Replication and Cell-Cell Fusion  

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...regulation of cell-cell fusion. Herpes simplex virus type 1 (HSV-1), a...abolished the cell fusion phenotype associated with the wild-type gB and the gB dileucine...herpes simplex virus type 1 glycoprotein B-induced fusion. J. Virol. 68...

Igor Beitia Ortiz de Zarate; Lilia Cantero-Aguilar; Magalie Longo; Clarisse Berlioz-Torrent; Flore Rozenberg

2007-10-03T23:59:59.000Z

267

Rhesus monkeys kidney cells persistently infected with Simian Virus 40: production of defective interfering virus and acquisition of the transformed phenotype.  

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...the carrier culture was defective at both 31 and 37?C...these carrier cultures is defective and able to interfere...SV40. In addition, the car- rier cultures express...genetically susceptible to the car- ried virus are made...such as interferon or defective viruses (i.e., 6...

L C Norkin

1976-09-01T23:59:59.000Z

268

Drug Therapy: Management of Human Immunodeficiency Virus Infection in Pregnancy  

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An estimated 16.4 million women worldwide are living with human immunodeficiency virus (HIV) infection; 600,000 children are infected annually, most of them by mother-to-child transmission. Interventions designed to reduce perinatal transmission of HIV in the developing world have been described... Globally, more than 16 million women are living with human immunodeficiency virus (HIV) infection. Each year, 600,000 children are infected, most of them through mother-to-child transmission. This review focuses on the management of HIV infection during pregnancy in developed countries in which antiretroviral therapy, scheduled cesarean delivery, and alternatives to breast-feeding are available; it discusses strategies for obtaining the best possible outcomes.

Watts D.H.

2002-06-13T23:59:59.000Z

269

The stochastic entry of enveloped viruses: Fusion vs. endocytosis  

E-Print Network (OSTI)

Viral infection requires the binding of receptors on the target cell membrane to glycoproteins, or ``spikes,'' on the viral membrane. The initial entry is usually classified as fusogenic or endocytotic. However, binding of viral spikes to cell surface receptors not only initiates the viral adhesion and the wrapping process necessary for internalization, but can simultaneously initiate direct fusion with the cell membrane. Both fusion and internalization have been observed to be viable pathways for many viruses. We develop a stochastic model for viral entry that incorporates a competition between receptor mediated fusion and endocytosis. The relative probabilities of fusion and endocytosis of a virus particle initially nonspecifically adsorbed on the host cell membrane are computed as functions of receptor concentration, binding strength, and number of spikes. We find different parameter regimes where the entry pathway probabilities can be analytically expressed. Experimental tests of our mechanistic hypotheses are proposed and discussed.

Tom Chou

2007-03-02T23:59:59.000Z

270

Development of simulation tools for virus shell assembly. Final report  

SciTech Connect

Prof. Berger's major areas of research have been in applying computational and mathematical techniques to problems in biology, and more specifically to problems in protein folding and genomics. Significant progress has been made in the following areas relating to virus shell assembly: development has been progressing on a second-generation self-assembly simulator which provides a more versatile and physically realistic model of assembly; simulations are being developed and applied to a variety of problems in virus assembly; and collaborative efforts have continued with experimental biologists to verify and inspire the local rules theory and the simulator. The group has also worked on applications of the techniques developed here to other self-assembling structures in the material and biological sciences. Some of this work has been conducted in conjunction with Dr. Sorin Istrail when he was at Sandia National Labs.

Berger, Bonnie

2001-01-05T23:59:59.000Z

271

Ecological and Molecular Characterization of Avian Influenza Viruses Obtained from Waterfowl on the Texas Coast  

E-Print Network (OSTI)

combinations isolated. Similar to most surveillance studies, we found no significant difference in AIV infection based on host sex, but did find that juveniles were more likely to be positive for AIV than adults. We also documented that dabbling ducks were................................................... 7 1.2 Ecology of type A influenza viruses ................................ 7 1.2.1 Wild aquatic birds and avian influenza viruses............ 9 1.2.2 Surveillance for avian influenza virus in wild aquatic...

Ferro, Pamela Joyce

2011-10-21T23:59:59.000Z

272

Crystallization and preliminary X-ray analysis of the matrix protein from Ebola virus  

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The Ebola virus matrix protein VP40 has been expressed, purified and crystallized in space group C2. Crystals diffract to 1.9 using synchrotron radiation.

Dessen, A.

2000-06-01T23:59:59.000Z

273

E-Print Network 3.0 - asociado al virus Sample Search Results  

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University of Warwick Collection: Mathematics 16 Introduction: Molecular Bio-Hacking Department of Bioengineering Summary: infection DNA RNA protein (host DNA) + (virus...

274

E-Print Network 3.0 - anticuerpos al virus Sample Search Results  

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University of Warwick Collection: Mathematics 12 Introduction: Molecular Bio-Hacking Department of Bioengineering Summary: infection DNA RNA protein (host DNA) + (virus...

275

E-Print Network 3.0 - asocia al virus Sample Search Results  

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University of Warwick Collection: Mathematics 3 Introduction: Molecular Bio-Hacking Department of Bioengineering Summary: infection DNA RNA protein (host DNA) + (virus...

276

E-Print Network 3.0 - al virus vhs-1 Sample Search Results  

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University of Warwick Collection: Mathematics 7 Introduction: Molecular Bio-Hacking Department of Bioengineering Summary: infection DNA RNA protein (host DNA) + (virus...

277

E-Print Network 3.0 - anaemia virus isav-infected Sample Search...  

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and Human Development Collection: Biology and Medicine 93 Introduction: Molecular Bio-Hacking Department of Bioengineering Summary: infection DNA RNA protein (host DNA) + (virus...

278

E-Print Network 3.0 - acute nipah virus Sample Search Results  

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H5N1 avian influenza, can be analyzed to estimate... Rabies virus III (Spillover + stuttering chains) Andes ... Source: Grether, Gregory - Department of Ecology and Evolutionary...

279

E-Print Network 3.0 - anti-herpes simplex virus Sample Search...  

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with herpes simplex virus (HSV).Using congenic strains of mice, we found that the lgh... immune factors influence the clinical expres- sion of herpes ... Source: Knipe,...

280

In vitro studies of single-stranded RNA virus self-assembly.  

E-Print Network (OSTI)

??Viruses are self-replicating nucleoprotein complexes that have the ability to cause diseases and are composed of, at least, a single copy of genetic material (either (more)

Comas Garcia, Mauricio

2013-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

E-Print Network 3.0 - anti-virus business optimal Sample Search...  

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. Trademarks Symantec, the Symantec logo, Norton AntiVirus, and LiveUpdate are U.S registered ... Source: Khatiwala, Samar - Lamont-Doherty Earth Observatory, Columbia...

282

E-Print Network 3.0 - attenuated live-virus vaccine Sample Search...  

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virus (HIV) vaccines are unlikely to prevent acquisition of HIV in all Source: Gilbert, Peter - Fred Hutchinson Cancer Research Center & Department of Biostatistics,...

283

E-Print Network 3.0 - adeno-associated virus vectors Sample Search...  

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virus vectors: A historical perspective. Mol. Ther. 10... ., and NATH- WANI, A.C. (2004). ... Source: Mandel, Ronald J. - Department of Neuroscience, University of...

284

E-Print Network 3.0 - adeno-associated virus vector Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

virus vectors: A historical perspective. Mol. Ther. 10... ., and NATH- WANI, A.C. (2004). ... Source: Mandel, Ronald J. - Department of Neuroscience, University of...

285

E-Print Network 3.0 - anticuerpos contra virus Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

more than 10,000 DOS-based computer viruses. In addition to the ... Source: Perrig, Adrian - Department of Electrical and Computer Engineering, Carnegie Mellon University...

286

Microcalorimetric study of virus infection; The effects of hyperthermia and 1b recombinant homo interferon on the infection process of BHK-21 cells by foot and mouth disease virus  

Science Journals Connector (OSTI)

The metabolic process of BHK-21 cell line infected by foot and mouth disease virus (FMDV) was ... present study is to investigate the metabolic thermal power of the virus infection process of BHK- ... process. In...

Z. Heng; Z. Congyi; W. Cunxin; W. Jibin

2005-01-01T23:59:59.000Z

287

Correlation of hepatitis B virus, hepatitis D virus and human immunodeficiency virus type I infection markers in hepatitis B surface antigen positive haemophiliacs and patients without haemophilia with clinical and histopathological outcome of hepatitis  

Science Journals Connector (OSTI)

The hepatitis D virus (HDV) infection plays a major role in severe liver damage caused by hepatitis. To establish the prevalence of HDV infection in haemophilic patients and patients without haemophilia, 87 pa...

N. Wagner; H. W. Rotthauwe; M. Becker; H. P. Dienes

1992-02-01T23:59:59.000Z

288

Identification of Inhibitors that Block Vaccinia Virus Infection by Targeting the DNA Synthesis Processivity Factor D4  

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However, surreptitious stocks of variola virus, the causative agent of smallpox, pose a threat to the reemergence of this disease. ... Therapeutic compounds are needed to prevent a smallpox attack arising from a surreptitious release of variola virus. ...

Manunya Nuth; Lijuan Huang; Yih Ling Saw; Norbert Schormann; Debasish Chattopadhyay; Robert P. Ricciardi

2011-03-25T23:59:59.000Z

289

Genetic modification of alternative respiration in Nicotiana benthamiana affects basal and salicylic acid-induced resistance to potato virus X  

E-Print Network (OSTI)

constitutively expressing a functional RNA-dependent RNA polymerase (MtRDR1). Unexpectedly, Aox-transgenic plants infected with potato virus X (PVX) showed markedly increased susceptibility to systemic disease induction and virus accumulation in inoculated...

Lee, Wing-Sham; Fu, Shih-Feng; Verchot-Lubicz, Jeanmarie; Carr, John P

2011-02-28T23:59:59.000Z

290

Dominance of resistance-breaking cotton leaf curl Burewala virus (CLCuBuV) in northwestern India  

Science Journals Connector (OSTI)

Monitoring the virus sequences over a period of time helps in tracing the origin and/or introduction of a particular virus isolate in a specific region [16, 44]. Detailed sequence analysis of 258 CBV isolates dem...

Prem A. Rajagopalan; Amruta Naik; Prashanth Katturi

2012-05-01T23:59:59.000Z

291

Studies of Ebola Virus Glycoprotein-Mediated Entry and Fusion by Using Pseudotyped Human Immunodeficiency Virus Type 1 Virions: Involvement of Cytoskeletal Proteins and Enhancement by Tumor Necrosis Factor Alpha  

Science Journals Connector (OSTI)

...ARTICLE VIRUS-CELL INTERACTIONS Studies of Ebola Virus Glycoprotein-Mediated Entry and...California, San Francisco, California The Ebola filoviruses are aggressive pathogens that...analyze the entry and fusion properties of Ebola virus, we adapted a human immunodeficiency...

Akihito Yonezawa; Marielle Cavrois; Warner C. Greene

2005-01-01T23:59:59.000Z

292

Microsoft Word - Avian Flu Statement3-2008.doc  

NLE Websites -- All DOE Office Websites (Extended Search)

National Nuclear Security Administration National Nuclear Security Administration WWW.LANL.GOV Statement CONTACT: Nancy Ambrosiano, 505-667-0471, nwa@lanl.gov March 7, 2008 Statement on Avian Influenza Research at Los Alamos Los Alamos National Laboratory has pursued a robust experimental program in the biosciences for decades, and a major focus of its bioscience research in the past decade is in the area of biosecurity and public health. This research is both theoretical and computational, and it also involves direct laboratory experimental work with viable pathogens. The pathogen work done at Los Alamos is currently at the Biosafety Level 2 (BSL-2) level, and includes work with biological agents on the Centers for Disease Control (CDC) and U.S. Department of Agriculture (USDA) Select Agent and Toxin list. Although the site has a

293

Information From Your Health Care ProviderGASTROENTERITIS (Stomach Flu)  

E-Print Network (OSTI)

are bacterial or parasitic infections, food- borne toxins, shellfish and marine animal poisoning, food an object that has germs on it. Contaminated food or water is another source for infection. · Other causes, or antacids. · Contaminated food or water. · Travel to foreign countries. PREVENTIVE MEASURES · No specific

Rusu, Adrian

294

Swine Flu and Common Infections to Prepare For  

E-Print Network (OSTI)

particles can travel up to 12 feet through the air when someone with a cold coughs or sneezes http symptoms: ­ Headache or pressure on the face ­ Cough ­ Stuffy nose Nose drainage ("snots") or phlegm (rest do not require antibiotics) ­ Fever, swollen lymph nodes, no cough, white spots on tonsils

Goldman, Steven A.

295

BACTERIAL MENINGITIS AND SWINE FLU THE DIFFERENCES BETWEEN THE SYMPTOMS  

E-Print Network (OSTI)

bright lights stiff neck cough sore throat body aches runny nose congestion fatigue If you think you have

Oxford, University of

296

Preventing the Flu Good Health Habits Can Help Stop Germs  

E-Print Network (OSTI)

mouth and nose. When coughing or sneezing, cover your mouth and nose with a tissue or your inside elbow

Rhode Island, University of

297

Inhibition of Host Cell Ribosomal Ribonucleic Acid Methylation by Foot-and-Mouth Disease Virus  

Science Journals Connector (OSTI)

...chromatography, which has a high resolving power for the nucleic acids (based on secondary...and J. Polatnick. 1968. The site of foot-and-mouth disease virus ribonucleic...and G. Vande Woude. 1966. Studies on foot-and-mouth disease virus ribonucleic...

Richard Ascione; George F. Vande Woude

1969-11-01T23:59:59.000Z

298

Effects of Heat on the Infecting, Antibody-Absorbing, and Interfering Powers of Vaccinia Virus  

Science Journals Connector (OSTI)

...antibody-reactive power of the virus, which...et al. (1957) on foot-and-mouth disease...the plaque- forming power of vaccinia virus...the introduction for foot-and-mouth disease...superior interfering power. ACKNOWLEDGMENTS...Inactivation of foot-and- mouth disease...

G. J. Galasso; D. G. Sharp

1965-03-01T23:59:59.000Z

299

Degradation of Nuclear Factor Kappa B during Foot-and-Mouth Disease Virus Infection  

Science Journals Connector (OSTI)

...followed by 5 s of sonication at medium power in a Microsom XL2005 apparatus (Heat System...and C. A. Timpone. 1984. Epitopes on foot-and-mouth disease virus outer capsid...A region of the 5 noncoding region of foot-and-mouth disease virus RNA directs...

Teresa de los Santos; Fayna Diaz-San Segundo; Marvin J. Grubman

2007-09-19T23:59:59.000Z

300

Role of glycoprotein B of herpes simplex virus type 1 in viral entry and cell fusion.  

Science Journals Connector (OSTI)

...the syncytial pheno- type on HEL cells. Ceil fusion induced by gB-null viruses...gB in by an HpaI linker fusion. For both types of cells infected with...alterations that affect cell fusion in herpes simplex virus type 1. Virology 132:368-376...

W H Cai; B Gu; S Person

1988-08-01T23:59:59.000Z

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Histopathological and Immunohistochemical Studies of Lesions Associated with Ebola Virus in a Naturally Infected Chimpanzee  

E-Print Network (OSTI)

S54 Histopathological and Immunohistochemical Studies of Lesions Associated with Ebola Virus'Ivoire Lesions caused by the Co^te d'Ivoire subtype of Ebola virus in a naturally infected young chimpan- zee, so perti-A new subtype of Ebola (EBO) filovirus designated EBO nent laboratory analyses were done

302

Information regarding Ebola Virus Disease (EVD) for Campus Personnel and Visitors September 5, 2014  

E-Print Network (OSTI)

Information regarding Ebola Virus Disease (EVD) for Campus Personnel and Visitors September 5, 2014 You are likely very much aware of the ongoing attention focused on the Ebola Virus Disease (EVD Control and Prevention (CDC) considers Ebola to pose little risk to persons in the U.S. at this time. We

Gerdes, J. Christian

303

Inactivation of Viruses in Bubbling Processes Utilized for Personal Bioaerosol Monitoring  

Science Journals Connector (OSTI)

...Medical and Health Physics, Queensland University...the carrier gas passes through and thus...the inactivation rate of viruses in...turns by 180 and passes through the porous...the recovery rate of stress-sensitive...the carrier gas passes through and thus...the inactivation rate of viruses in...

I. E. Agranovski; A. S. Safatov; A. I. Borodulin; O. V. Pyankov; V. A. Petrishchenko; A. N. Sergeev; A. P. Agafonov; G. M. Ignatiev; A. A. Sergeev; V. Agranovski

2004-12-01T23:59:59.000Z

304

Contact heterogeneity in deer mice: implications for Sin Nombre virus transmission  

Science Journals Connector (OSTI)

...J Beaty1999Natural history of Sin Nombre Virus in Western Colorado. Emerg. Infect. Dis. 5, 126-134. Calisher...of antibody to Sin Nombre virus in deer mice in the western United States. J. Wildl. Dis. 43, 1-11. Childs...

2009-01-01T23:59:59.000Z

305

Airborne Transmission of Highly Pathogenic H7N1 Influenza Virus in Ferrets  

Science Journals Connector (OSTI)

...equipment and standard operating procedures. Only after...monthly departmental training sessions and a yearly...influenza viruses. All personnel working at BSL3+ must...suggesting a degree of selection. It is possible that...Perez. 2013. In vivo selection of H1N2 influenza virus...

Troy C. Sutton; Courtney Finch; Hongxia Shao; Matthew Angel; Hongjun Chen; Ilaria Capua; Giovanni Cattoli; Isabella Monne; Daniel R. Perez

2014-04-02T23:59:59.000Z

306

Chlorella Virus PBCV-1 Encodes a Functional Homospermidine Synthase Annette Kaiser,*,1  

E-Print Network (OSTI)

Chlorella Virus PBCV-1 Encodes a Functional Homospermidine Synthase Annette Kaiser,*,1 Michael 16, 1999 Sequence analysis of the 330-kb genome of chlorella virus Paramecium bursaria chlorella uninfected and PBCV-1-infected chlorella, as well as PBCV-1 virions, contain homospermidine, along

Graves, Michael V.

307

Stamped microbattery electrodes based on self-assembled M13 viruses  

Science Journals Connector (OSTI)

...in this study could enable economical small-scale patterning of viruses and virus-templated...Solid-state dye-sensitized solar cells combining a porous TiO2 film...Nanostructured materials for advanced energy conversion and storage devices . Nat Mater 4...Bacteriophage M13 chemistry Bioelectric Energy Sources virology Electrochemistry...

Ki Tae Nam; Ryan Wartena; Pil J. Yoo; Forrest W. Liau; Yun Jung Lee; Yet-Ming Chiang; Paula T. Hammond; Angela M. Belcher

2008-01-01T23:59:59.000Z

308

IMPRINTED MICROFLUIDIC DEVICE FOR BIOIN-SPIRED DETECTION OF AVIAN INFLUNZA VIRUS  

E-Print Network (OSTI)

IMPRINTED MICROFLUIDIC DEVICE FOR BIOIN- SPIRED DETECTION OF AVIAN INFLUNZA VIRUS USING NANOWIRES for the detection of avian influenza virus. A roll-to-roll im- printed microfluidic device suitable for simple process were integrated to the designed microfluidic chip (Figure 1). Using this system, we developed

309

Molecular Biology of Pseudorabies Virus: Impact on Neurovirology and Veterinary Medicine  

Science Journals Connector (OSTI)

...from pseudorabies virus challenge in mice by a combination...Peeters, B., N. de Wind, M. Hooisma, F. Wagenaar...van der Gulden, N. de Wind, A. Gielkens, and...L. Gielkens, N. de Wind, and T. G. Kimman...disease virus following challenge in previously vaccinated...

Lisa E. Pomeranz; Ashley E. Reynolds; Christoph J. Hengartner

2005-09-01T23:59:59.000Z

310

Predicted Inactivation of Viruses of Relevance to Biodefense by Solar Radiation  

Science Journals Connector (OSTI)

...of Relevance to Biodefense by Solar Radiation C. David Lytle Jose-Luis...estimate inactivation of viruses by solar exposure. We reviewed published...74 Tyrrell, R. M. 1978. Solar dosimetry with repair deficient...cells: similar increase in capacity to replicate intact minute-virus-of-mice...

C. David Lytle; Jose-Luis Sagripanti

2005-11-15T23:59:59.000Z

311

Venezuelan equine encephalitis virus entry mechanism requires late endosome formation and resists cell membrane cholesterol depletion  

SciTech Connect

Virus envelope proteins determine receptor utilization and host range. The choice of receptor not only permits specific targeting of cells that express it, but also directs the virus into specific endosomal trafficking pathways. Disrupting trafficking can result in loss of virus infectivity due to redirection of virions to non-productive pathways. Identification of the pathway or pathways used by a virus is, thus, important in understanding virus pathogenesis mechanisms and for developing new treatment strategies. Most of our understanding of alphavirus entry has focused on the Old World alphaviruses, such as Sindbis and Semliki Forest virus. In comparison, very little is known about the entry route taken by more pathogenic New World alphaviruses. Here, we use a novel contents mixing assay to identify the cellular requirements for entry of a New World alphavirus, Venezuelan equine encephalitis virus (VEEV). Expression of dominant negative forms of key endosomal trafficking genes shows that VEEV must access clathrin-dependent endocytic vesicles for membrane fusion to occur. Unexpectedly, the exit point is different from Old World alphaviruses that leave from early endosomes. Instead, VEEV also requires functional late endosomes. Furthermore, unlike the Old World viruses, VEEV entry is insensitive to cholesterol sequestration from cell membranes and may reflect a need to access an endocytic compartment that lacks cholesterol. This indicates fundamental differences in the entry route taken by VEEV compared to Old World alphaviruses.

Kolokoltsov, Andrey A. [Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 (United States); Fleming, Elisa H. [Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 (United States); Davey, Robert A. [Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 (United States)]. E-mail: radavey@utmb.edu

2006-04-10T23:59:59.000Z

312

Spatial analysis of West Nile Virus and predictors of hyperendemicity in the Texas equine industry  

E-Print Network (OSTI)

SPATIAL ANALYSIS OF WEST NILE VIRUS AND PREDICTORS OF HYPERENDEMICITY IN THE TEXAS EQUINE INDUSTRY A Thesis by COURTNEY ANNE WITTICH Submitted to the Office of Graduate Studies of Texas A&M University... in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE December 2007 Major Subject: Veterinary Public Health SPATIAL ANALYSIS OF WEST NILE VIRUS AND PREDICTORS OF HYPERENDEMICITY...

Wittich, Courtney Anne

2008-10-10T23:59:59.000Z

313

Establishment of a Chimeric, Replication-Deficient Influenza A Virus Vector by Modulation of Splicing Efficiency  

Science Journals Connector (OSTI)

...of the influenza A virus codes for two proteins (NS1 and NS2/NEP) via splicing. Here...for polypeptides NS1 and NS2 on RNA segment 8 of influenza...of the influenza A virus codes for two proteins (NS1 and NS2/NEP) via splicing. Here...

Markus Wolschek; Elisabeth Samm; Helena Seper; Sanda Sturlan; Irina Kuznetsova; Cornelia Schwager; Alexandra Khassidov; Christian Kittel; Thomas Muster; Andrej Egorov; Michael Bergmann

2010-12-22T23:59:59.000Z

314

Segment 8 of the influenza virus genome is unique in coding for two polypeptides  

Science Journals Connector (OSTI)

...genome segment 8 of influenza virus codes for NS2. MATERIALS AND METHODS Viruses...above evidence that a separate mRNA codes for NS2 indi- cate that RNA segment 8...determining which genome segment codes for NS2. By examining recombinants with...

R A Lamb; P W Choppin

1979-01-01T23:59:59.000Z

315

Influenza A Virus NEP (NS2 Protein) Downregulates RNA Synthesis of Model Template RNAs  

Science Journals Connector (OSTI)

...REPLICATION Influenza A Virus NEP (NS2 Protein) Downregulates RNA Synthesis...The influenza A virus NEP (NS2) protein is an structural component...with the viral RNA segment and codes for NS1 protein, and the other...named nonstructural protein 2 (NS2) (, ). More recently, however...

Rosario Bullido; Paulino Gmez-Puertas; Mar??a Jos Saiz; Agust??n Portela

2001-05-01T23:59:59.000Z

316

Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach  

Science Journals Connector (OSTI)

...influenza A viruses express comparable levels of the viral NEP (NS2), the second protein encoded by the viral NS gene (Fig. 1 A...examined whether influenza B/Yamagata virus derivatives that code for shortened NS1 proteins would show growth attenuation in older...

Julie Talon; Mirella Salvatore; Robert E. O'Neill; Yurie Nakaya; Hongyong Zheng; Thomas Muster; Adolfo Garca-Sastre; Peter Palese

2000-01-01T23:59:59.000Z

317

Saaremaa Hantavirus Should Not Be Confused with Its Dangerous Relative, Dobrava Virus  

Science Journals Connector (OSTI)

...Should Not Be Confused with Its Dangerous Relative, Dobrava Virus Alexander...known to be one of the most dangerous European viral pathogens...Research Institute for Animal Health Institute for Novel and Emerging...should not be confused with its dangerous relative, Dobrava virus...

Alexander Plyusnin; Antti Vaheri; ke Lundkvist

2006-04-01T23:59:59.000Z

318

Tomato Bushy Stunt Virus Recombination Guided by Introduced MicroRNA Target Sequences  

Science Journals Connector (OSTI)

...J. C. Anderson, G. B. Martin, and S. P. Dinesh-Kumar. 2004. Applications and advantages of virus-induced...Burch-Smith, T. M., M. Schiff, Y. Liu, and S. P. Dinesh-Kumar. 2006. Efficient virus-induced gene silencing in...

Pavan Kumar; Sandra Uratsu; Abhaya Dandekar; Bryce W. Falk

2009-07-29T23:59:59.000Z

319

Treatment of Chronic Hepatitis C Virus Infection: A Clinical and Virological Perspective  

Science Journals Connector (OSTI)

Hepatitis C virus (HCV), the etiologic agent of chronic non-A, non-B hepatitis,is a 9.4 kb positive strand RNA virus classified within the Flaviviridae family.1 The RNA genome of HCV encodes a single precursor po...

David R. Gretch; Stephen J. Polyak; Richard A. Willson

1996-01-01T23:59:59.000Z

320

Dahlia Mosaic Virus: A Pictorial Guide to Symptoms and Diagnosis Prepared by  

E-Print Network (OSTI)

Dahlia Mosaic Virus: A Pictorial Guide to Symptoms and Diagnosis Prepared by Dr. Hanu R. Pappu virus Dr. Hanu R. Pappu, Associate Professor, Department of Plant Pathology, Washington State University Society, Fourth Quarter, December 2004) has additional details. Acknowledgements: *Dr. Pappu holds

Pappu, Hanu R.

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
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We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Mutations That Hamper Dimerization of Foot-and-Mouth Disease Virus 3A Protein Are Detrimental for Infectivity  

Science Journals Connector (OSTI)

...non-structural proteins of foot-and-mouth disease virus...Donaldson. 2001. Outbreak of foot-and-mouth disease virus...and JM Matthews. 2004. The power of two: protein dimerization...cells: a comparative study with foot-and-mouth disease virus...

Mnica Gonzlez-Magaldi; Ral Postigo; Beatriz G. de la Torre; Yuri A. Vieira; Miguel Rodrguez-Pulido; Eduardo Lpez-Vias; Paulino Gmez-Puertas; David Andreu; Leonor Kremer; Mara F. Rosas; Francisco Sobrino

2012-07-11T23:59:59.000Z

322

The UL45 gene product is required for herpes simplex virus type 1 glycoprotein B-induced fusion.  

Science Journals Connector (OSTI)

...required for herpes simplex virus type 1 glycoprotein B-induced fusion. E J Haanes C M Nelson C L Soule...required for herpes simplex virus type 1 glycoprotein B-induced fusion. | Herpes simplex virus type 1 (HSV-1) syncytial (syn...

E J Haanes; C M Nelson; C L Soule; J L Goodman

1994-09-01T23:59:59.000Z

323

Chlorella Virus PBCV-1 Encodes Functional Glutamine: Fructose-6-Phosphate Amidotransferase and UDP-Glucose Dehydrogenase Enzymes  

E-Print Network (OSTI)

Chlorella Virus PBCV-1 Encodes Functional Glutamine: Fructose-6-Phosphate Amidotransferase and UDP August 18, 1998 DNA sequence analysis of the 330-kb Chlorella virus PBCV-1 genome unexpectedly revealed the Chlorella viruses. The products of the reactions catalyzed by these two enzymes are precursors

Graves, Michael V.

324

An Avian Influenza Virus from Waterfowl in South America Contains Genes from North American Avian and Equine Lineages  

E-Print Network (OSTI)

An Avian Influenza Virus from Waterfowl in South America Contains Genes from North American Avian in 2002, there have been few reports of avian influenza in South America. However, surveillance in free to an equine influenza virus from South America. RESUMEN. Un virus de influenza aviar aislado de aves acua

McCracken, Kevin G.

325

Epstein-Barr Virus Nuclear Antigen Leader Protein Induces Expression of Thymus- and Activation-Regulated Chemokine in B Cells  

Science Journals Connector (OSTI)

...Technology (MEXT) of Japan and the Japan Society for the...Epstein-Barr virus nuclear antigen 5 inhibits...Dussault, C. A. Powers, A. E. Proudfoot...gastric carcinoma in Japan. Virus Genes 19...Epstein-Barr virus nuclear antigen leader protein...

Mikiko Kanamori; Shinya Watanabe; Reiko Honma; Masayuki Kuroda; Shosuke Imai; Kenzo Takada; Naoki Yamamoto; Yukihiro Nishiyama; Yasushi Kawaguchi

2004-04-01T23:59:59.000Z

326

Expression of IFN? by a recombinant rabies virus strongly attenuates the pathogenicity of the virus via induction of type I interferon  

Science Journals Connector (OSTI)

...replication and spread limiting its pathogenicity in normal and immunocompromised mice. Therefore, vector delivery of IFNgamma to the brain may have the potential to treat individuals who would otherwise succumb to infection with rabies virus.

Darryll A. Barkhouse; Samantha A. Garcia; Emily K. Bongiorno; Aurore Lebrun; Milosz Faber; D. Craig Hooper

2014-10-15T23:59:59.000Z

327

Infectious clones of Tomato leaf curl Palampur virus with a defective DNA B and their pseudo-recombination with Tomato leaf curl New Delhi virus  

Science Journals Connector (OSTI)

As described earlier, a very severe yellow leaf curl disease was observed in several districts of central and southern Punjab, including Vehari, Sahiwal and Khanewal, and was shown...Zucchini yellow mosaic virus ...

Aamir Humayun Malik; Rob W Briddon; Shahid Mansoor

2011-04-01T23:59:59.000Z

328

V-101: McAfee VirusScan Enterprise Lets Local Users Gain Elevated  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

1: McAfee VirusScan Enterprise Lets Local Users Gain Elevated 1: McAfee VirusScan Enterprise Lets Local Users Gain Elevated Privileges V-101: McAfee VirusScan Enterprise Lets Local Users Gain Elevated Privileges February 28, 2013 - 12:05am Addthis PROBLEM: McAfee VirusScan Enterprise Lets Local Users Gain Elevated Privileges PLATFORM: VSE 8.8 Patch 2 with Access Protection, including Self Protection, turned off ABSTRACT: A vulnerability was reported in McAfee VirusScan Enterprise. REFERENCE LINKS: McAfee Security Bulletins ID: SB10038 SecurityTracker Alert ID: 1028209 IMPACT ASSESSMENT: Medium DISCUSSION: When Access Protection has been disabled, a local user can gain full control of the target application IMPACT: A local user can obtain elevated privileges on the target system. SOLUTION: The vendor has issued a fix (8.8 Patch 2 with HF778101, 8.8 Patch 3)

329

Structure of the Ebola virus glycoprotein bound to an antibody from a human  

NLE Websites -- All DOE Office Websites (Extended Search)

8 8 Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor Ebolavirus: The ebolavirus causes a severe hemorrhagic fever with 50-90% lethality for which no vaccines or treatments are yet available. The more frequent re-emergence of the virus, its high prevalence among wildlife, and ease of importation of the virus make it a significant public health concern. A team of researchers have recently determined the crystal structure of the oligomeric, viral surface glycoprotein in complex with a rare antibody derived from a human survivor. This work explains how the glycoprotein, termed GP, mediates host recognition, drives fusion of the viral and host membranes and masks itself from immune surveillance. The structure also explains why antibodies that neutralize the virus are so rare, identifies the very few sites to which a neutralizing antibody might bind, and thus, provides templates for vaccines and antibodies against the virus.

330

A Virus That Can Infect Lung Cancer Cells | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

Imaging Plant Viruses Could Yield New Ways to Safeguard Crops Imaging Plant Viruses Could Yield New Ways to Safeguard Crops Extreme Pressure Reveals a Volume Expansion Phenomenon A Nuclear Receptor with Implications for a Host of Diseases Unexpected Materials in Earth's Lowermost Mantle Nailing Down the Exciton in LiF Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed A Virus That Can Infect Lung Cancer Cells OCTOBER 21, 2008 Bookmark and Share The 3-D structure of Seneca Valley Virus-001. (Courtesy: The Scripps Research Institute) The structure of the Senecavirus is also depicted at http://viperdb.scripps.edu/, the "Virus Particle Explorer" developed at Scripps Research by Reddy and his colleagues. The online database is a

331

V-101: McAfee VirusScan Enterprise Lets Local Users Gain Elevated  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

1: McAfee VirusScan Enterprise Lets Local Users Gain Elevated 1: McAfee VirusScan Enterprise Lets Local Users Gain Elevated Privileges V-101: McAfee VirusScan Enterprise Lets Local Users Gain Elevated Privileges February 28, 2013 - 12:05am Addthis PROBLEM: McAfee VirusScan Enterprise Lets Local Users Gain Elevated Privileges PLATFORM: VSE 8.8 Patch 2 with Access Protection, including Self Protection, turned off ABSTRACT: A vulnerability was reported in McAfee VirusScan Enterprise. REFERENCE LINKS: McAfee Security Bulletins ID: SB10038 SecurityTracker Alert ID: 1028209 IMPACT ASSESSMENT: Medium DISCUSSION: When Access Protection has been disabled, a local user can gain full control of the target application IMPACT: A local user can obtain elevated privileges on the target system. SOLUTION: The vendor has issued a fix (8.8 Patch 2 with HF778101, 8.8 Patch 3)

332

Environmental assessment of curly top virus control in California  

SciTech Connect

Curly top is a viral disease of sugarbeets, tomatoes, melons, peppers, beans, cucumbers, squash, pumpkins, spinach, vineseed and other commercially important crops, including ornamentals. Curly top not only infects commercial crops, but at times devastates backyard vegetable and flower gardens. The only known vector of curly top is Circulifer tenellus, commonly known as the beet leafhopper. Control of the beet leafhopper may take place at various locations throughout the San Joaquin Valley, Salinas Valley, Cuyama Valley, Antelope Valley of northern Los Angeles County, Riverside County and the Imperial Valley (See Maps in Appendix ``E``), including portions of Merced, Fresno, Kings. Kern, San Luis Obispo, Monterey, San Benito, Santa Barbara, Los Angeles, Riverside and Imperial Counties. The size of the control program is totally dependent on the location, size, nd distribution of the beet leafhopper population. In a year with a low population, only 80,000 acres in western Fresno, Kings, and Kern Counties may require treatment. In a drought year, the treatment required may increase to more than 200,000 acres and include some inter-coastal valleys of Monterey, San Luis Obispo and Santa Barbara Counties. Not all areas require treatment on an annual basis and at no time is the entire area subject to blanket treatment. The Curly Top Virus Control Program (CTVCP) was instrumental in supporting research which developed an antisera allowing the use of Enzyme-Linked Immunosorbent Assay to determine the presence, on a percentage basis, of curly top virus. Thus, the amount of virus found in a given area lends weight to treatment priorities.

Not Available

1991-03-15T23:59:59.000Z

333

Structural determinants of tobacco vein mottling virus protease substrate specificity  

SciTech Connect

Tobacco vein mottling virus (TVMV) is a member of the Potyviridae, one of the largest families of plant viruses. The TVMV genome is translated into a single large polyprotein that is subsequently processed by three virally encoded proteases. Seven of the nine cleavage events are carried out by the NIa protease. Its homolog from the tobacco etch virus (TEV) is a widely used reagent for the removal of affinity tags from recombinant proteins. Although TVMV protease is a close relative of TEV protease, they exhibit distinct sequence specificities. We report here the crystal structure of a catalytically inactive mutant TVMV protease (K65A/K67A/C151A) in complex with a canonical peptide substrate (Ac-RETVRFQSD) at 1.7-{angstrom} resolution. As observed in several crystal structures of TEV protease, the C-terminus ({approx}20 residues) of TVMV protease is disordered. Unexpectedly, although deleting the disordered residues from TEV protease reduces its catalytic activity by {approx}10-fold, an analogous truncation mutant of TVMV protease is significantly more active. Comparison of the structures of TEV and TVMV protease in complex with their respective canonical substrate peptides reveals that the S3 and S4 pockets are mainly responsible for the differing substrate specificities. The structure of TVMV protease suggests that it is less tolerant of variation at the P1{prime} position than TEV protease. This conjecture was confirmed experimentally by determining kinetic parameters k{sub cat} and K{sub m} for a series of oligopeptide substrates. Also, as predicted by the cocrystal structure, we confirm that substitutions in the P6 position are more readily tolerated by TVMV than TEV protease.

Sun, Ping; Austin, Brian P.; Tozer, Jozsef; Waugh, David (Debrecen); (NCI)

2010-10-28T23:59:59.000Z

334

Inhibition of lytic infection of pseudorabies virus by arginine depletion  

SciTech Connect

Pseudorabies virus (PRV) is a member of Alphahepesviruses; it is an enveloped virus with a double-stranded DNA genome. Polyamines (such as spermine and spermidine) are ubiquitous in animal cells and participate in cellular proliferation and differentiation. Previous results of our laboratory showed that the PRV can accomplish lytic infection either in the presence of exogenous spermine (or spermidine) or depletion of cellular polyamines. The amino acid arginine is a precursor of polyamine biosynthesis. In this work, we investigated the role of arginine in PRV infection. It was found that the plaque formation of PRV was inhibited by arginase (enzyme catalyzing the conversion of arginine into ornithine and urea) treatment whereas this inhibition can be reversed by exogenous arginine, suggesting that arginine is essential for PRV proliferation. Western blotting was conducted to study the effect of arginine depletion on the levels of structural proteins of PRV in virus-infected cells. Four PRV structural proteins (gB, gE, UL47, and UL48) were chosen for examination, and results revealed that the levels of viral proteins were obviously reduced in long time arginase treatment. However, the overall protein synthesis machinery was apparently not influenced by arginase treatment either in mock or PRV-infected cells. Analyzing with native gel, we found that arginase treatment affected the mobility of PRV structural proteins, suggesting the conformational change of viral proteins by arginine depletion. Heat shock proteins, acting as molecular chaperons, participate in protein folding and translocation. Our results demonstrated that long time arginase treatment could reduce the expression of cellular heat shock proteins 70 (hsc70 and hsp70), and transcriptional suppression of heat shock protein 70 gene promoter was one of the mechanisms involved in this reduced expression.

Wang, H.-C. [Department of Veterinary Medicine, College of Veterinary Medicine, National Chung-Hsing University, Taichung 402, Taiwan (China); Kao, Y.-C. [Department of Veterinary Medicine, College of Veterinary Medicine, National Chung-Hsing University, Taichung 402, Taiwan (China); Chang, T-J. [Department of Veterinary Medicine, College of Veterinary Medicine, National Chung-Hsing University, Taichung 402, Taiwan (China); Wong, M.-L. [Department of Veterinary Medicine, College of Veterinary Medicine, National Chung-Hsing University, Taichung 402, Taiwan (China)]. E-mail: mlwong@dragon.nchu.edu.tw

2005-08-26T23:59:59.000Z

335

Contact with dogs, canine distemper virus, and multiple sclerosis  

E-Print Network (OSTI)

to 1945. It was further suggested that the occupation was accompanied by an influx of canine distemper virus through military dogs (44). In Sitka, Alaska, an increase in MS incidence also appeared to correlate with a previous epidemic of CDV... anti-human IgG heavy and light chain secondary antibody (Jackson ImmunoResearch Laboratories Inc, West Grove, PA) was used at a dilution of I:600. Each serum sample was run in four wells, and the average absorbance of the four replicates was used...

Hutka, Marcus Dietrich

1999-01-01T23:59:59.000Z

336

Feline Urological Syndrome: is a virus responsible for the disease?  

E-Print Network (OSTI)

that the inclusion bodies var ied in appear ence, apcearing somewhat different than those seen in cells infected with FHV. Other forms of CPE repor ted to occur in cells infected with CAHV include enlar ged cells, syncytia, snd loss of contact inhibition. Three... neutr alization (VN) tests were carr ied out using 100 TCID?&s of CAHV against antiserum crested to e number of her pesviruses, including: Feline herpesvirus type 1 (FHV1 ), Canine her pesvirus (CHV), Bovine mammalitis virus (BHV2), Pseudorabies...

Swansn, Cynthia Louise

1984-01-01T23:59:59.000Z

337

Ebola Virus Disease in the Democratic Republic of Congo  

Science Journals Connector (OSTI)

...EVD and had an epidemiologic link to a confirmed case but was not tested and did not have laboratory confirmation of the disease. A probable or suspected case was classified as confirmed when a sample from the affected person tested positive for EBOV in the laboratory. In this study, the final classification... On August 24, 2014, when the eyes of the world were on the spreading West African outbreak of Ebola virus disease (EVD), the World Health Organization (WHO) was notified of another EVD outbreak in the vicinity of Boende town, quateur province, in western ...

2014-10-15T23:59:59.000Z

338

Seeing the Smallest Steps  

NLE Websites -- All DOE Office Websites (Extended Search)

A Bird Flu Protein Link to Virulence A Bird Flu Protein Link to Virulence Smart viruses infect without killing the host, at least in the short term. In such low-level infections, the virus gains time to persist, reproduce, infect other individuals, and spread through the population. Some viruses persist in certain host populations without killing them, but in other hosts they have a rapid and deadly effect. The H5N1 virus strains responsible for recent lethal outbreaks of bird flu apparently existed for quite some time in wild goose populations without doing much harm. But when the same strains infected chickens, the results were disastrous, leading to high chicken mortality and a health risk for humans living in proximity. In fact, the risk of epidemic was considered high enough to lead China to

339

Interaction between Ebola Virus Glycoprotein and Host Toll-Like Receptor 4 Leads to Induction of Proinflammatory Cytokines and SOCS1  

Science Journals Connector (OSTI)

...VIRUS-CELL INTERACTIONS Interaction between Ebola Virus Glycoprotein and Host Toll-Like...Chiyoda-ku, Tokyo 102-0075, Japan Ebola virus initially targets monocytes and macrophages...development of circulatory shock seen in fatal Ebola virus infections. Here we report that...

Atsushi Okumura; Paula M. Pitha; Akihiko Yoshimura; Ronald N. Harty

2009-10-21T23:59:59.000Z

340

Isolation and partial characterisation of a new strain of Ebola We have isolated a new strain of Ebola virus from a non-  

E-Print Network (OSTI)

1271 Isolation and partial characterisation of a new strain of Ebola virus Summary We have isolated a new strain of Ebola virus from a non- fatal human case infected during the autopsy of a wild about the natural reservoir of the Ebola virus. Lancet 1995; 345: 1271-74 Introduction Ebola virus

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Chlorella viruses encode most, if not all, of the machinery to glycosylate their glycoproteins independent of the endoplasmic reticulum and Golgi  

E-Print Network (OSTI)

Review Chlorella viruses encode most, if not all, of the machinery to glycosylate 2009 Available online 3 August 2009 Keywords: Chlorella viruses PBCV-1 Virus, the large dsDNA-containing chlorella viruses encode most, if not all, of the components to glycosylate

Graves, Michael V.

342

Human APOBEC3G incorporation into murine leukemia virus particles  

Science Journals Connector (OSTI)

The human APOBEC3G protein exhibits broad antiretroviral activity against a variety of retroviruses. It is packaged into viral particles and executes its antiviral function in the target cell. The packaging of APOBEC3G into different viral particles requires a mechanism that confers this promiscuity. Here, APOBEC3G incorporation into murine leukemia virus (MLV) was studied using retroviral vectors. APOBEC3G uptake did not require either its cytidine deaminase activity or the presence of a retroviral vector genome. Results from immunoprecipitation and co-localization studies of APOBEC3G with a MLV GagCFP (cyan fluorescent protein) fusion protein imply an interaction between both proteins. \\{RNase\\} A treatment did not inhibit the co-precipitation of GagCFP and APOBEC3G, suggesting that the interaction is RNA independent. Like human immunodeficiency virus (HIV) Gag, the MLV Gag precursor protein appears to interact with APOBEC3G, indicating that Gag contains conserved structures which are used to encapsidate APOBEC3G into different retroviral particles.

Melanie Kremer; Alexandra Bittner; Barbara S. Schnierle

2005-01-01T23:59:59.000Z

343

Structure of the Ebola Virus Glycoprotein Bound to an Antibody from a Human  

NLE Websites -- All DOE Office Websites (Extended Search)

Structure of the Ebola Virus Structure of the Ebola Virus Glycoprotein Bound to an Antibody from a Human Survivor Structure of the Ebola Virus Glycoprotein Bound to an Antibody from a Human Survivor Print Wednesday, 26 November 2008 00:00 Ebolavirus, one of two members of the family of filoviruses, causes a severe hemorrhagic fever with 50-90% human mortality. That no vaccines or treatments are yet available combined with the frequent re-emergence of the virus, its high prevalence among wildlife, and ease of importation of the virus make it a significant public health concern. A team of researchers from the Scripps Research Institute, using diffraction data collected at ALS Beamline 5.0.2, has recently determined the crystal structure of an oligomeric glycoprotein from the viral surface in complex with a rare antibody derived from a human survivor. This work explains how the glycoprotein, termed GP, mediates recognition of the host cell, drives fusion of the viral and host membranes (necessary for viral entry into the host), and masks itself from immune surveillance. The structure also explains why antibodies that neutralize the virus are so rare, identifies the very few sites to which a neutralizing antibody might bind, and thus, provides templates for vaccines and antibodies against the virus.

344

Herpes Simplex Virus Type 1 gK Is Required for gB-Mediated Virus-Induced Cell Fusion, While neither gB and gK nor gB and UL20p Function Redundantly in Virion De-Envelopment  

Science Journals Connector (OSTI)

...virus-induced cell fusion: herpes simplex virus type 1 (HSV-1) mutants...alterations that affect cell fusion in herpes simplex virus type 1. Virology 132: 368-376...herpes simplex virus type 1 gene that causes cell fusion. Virology 145: 36-48...

Jeffrey M. Melancon; Rafael E. Luna; Timothy P. Foster; Konstantin G. Kousoulas

2005-01-01T23:59:59.000Z

345

V-021: Cisco IronPort Web / Email Security Appliance Sophos Anti-Virus  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

21: Cisco IronPort Web / Email Security Appliance Sophos 21: Cisco IronPort Web / Email Security Appliance Sophos Anti-Virus Multiple Vulnerabilities V-021: Cisco IronPort Web / Email Security Appliance Sophos Anti-Virus Multiple Vulnerabilities November 12, 2012 - 6:00am Addthis PROBLEM: Cisco IronPort Web / Email Security Appliance Sophos Anti-Virus Multiple Vulnerabilities PLATFORM: Cisco IronPort Email Security Appliances (C-Series and X-Series) running Sophos Engine versions 3.2.07.352_4.80 and prior. Cisco IronPort Web Security Appliances (S-Series) running Sophos Engine versions 3.2.07.352_4.80 and prior. ABSTRACT: Cisco Ironport Appliances Sophos Anti-Virus Vulnerabilities. REFERENCE LINKS: Cisco Security Advisory ID: cisco-sa-20121108-sophos Secunia Advisory SA51197 IMPACT ASSESSMENT: High DISCUSSION: Cisco has acknowledged some vulnerabilities in Cisco IronPort Web Security

346

V-021: Cisco IronPort Web / Email Security Appliance Sophos Anti-Virus  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

1: Cisco IronPort Web / Email Security Appliance Sophos 1: Cisco IronPort Web / Email Security Appliance Sophos Anti-Virus Multiple Vulnerabilities V-021: Cisco IronPort Web / Email Security Appliance Sophos Anti-Virus Multiple Vulnerabilities November 12, 2012 - 6:00am Addthis PROBLEM: Cisco IronPort Web / Email Security Appliance Sophos Anti-Virus Multiple Vulnerabilities PLATFORM: Cisco IronPort Email Security Appliances (C-Series and X-Series) running Sophos Engine versions 3.2.07.352_4.80 and prior. Cisco IronPort Web Security Appliances (S-Series) running Sophos Engine versions 3.2.07.352_4.80 and prior. ABSTRACT: Cisco Ironport Appliances Sophos Anti-Virus Vulnerabilities. REFERENCE LINKS: Cisco Security Advisory ID: cisco-sa-20121108-sophos Secunia Advisory SA51197 IMPACT ASSESSMENT: High DISCUSSION: Cisco has acknowledged some vulnerabilities in Cisco IronPort Web Security

347

Molecular Characterization of Three New Avian Infectious Bronchitis Virus (IBV) Strains Isolated in Quebec  

Science Journals Connector (OSTI)

Three unrecognized field isolates of Infectious Bronchitis Virus (IBV) were recovered from commercial broiler chickens vaccinated with live Mass viral strain (H120). These isolates were identified by immunoflu...

Ridha Smati; Amer Silim; Claude Guertin; Marc Henrichon; Mehdi Marandi

2002-08-01T23:59:59.000Z

348

Marburg and Ebola Viruses: New Agents on the Frontiers of Virology  

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Marburg virus was first isolated in 1967 in association with a devastating outbreak of hemorrhagic fever among laboratory workers in Germany and Yugoslavia [1]. Thirty-one people in two institutes were stricke...

Michael J. Buchmeier

1984-01-01T23:59:59.000Z

349

Physicochemical inactivation of Lassa, Ebola, and Marburg viruses and effect on clinical laboratory analyses  

SciTech Connect

Clinical specimens from patients infected with Lassa, Ebola, or Marburg virus may present a serious biohazard to laboratory workers. The authors have examined the effects of heat, alteration of pH, and gamma radiation on these viruses in human blood and on the electrolytes, enzymes, and coagulation factors measured in laboratory tests that are important in the care of an infected patient. Heating serum at 60 degrees C for 1 h reduced high titers of these viruses to noninfectious levels without altering the serum levels of glucose, blood urea nitrogen, and electrolytes. Dilution of blood in 3% acetic acid, diluent for a leukocyte count, inactivated all of these viruses. All of the methods tested for viral inactivation markedly altered certain serum proteins, making these methods unsuitable for samples that are to be tested for certain enzyme levels and coagulation factors.

Mitchell, S.W.; McCormick, J.B.

1984-09-01T23:59:59.000Z

350

Ebola virus infection in guinea pigs: presumable role of granulomatous inflammation in pathogenesis  

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An approach combining virology with light and electron microscopy was used to study the organs of guinea pigs during nine serial passages of Ebola virus, strain Zaire. It was observed that the wild type of Ebola ...

E. Ryabchikova; L. Kolesnikova; M. Smolina; V. Tkachev

1996-01-01T23:59:59.000Z

351

Effect of Ebola virus proteins GP, NP and VP35 on VP40 VLP morphology  

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Recently we described a role for Ebola virus proteins, NP, GP, and VP35 in enhancement of VP40 VLP budding. To explore the possibility that VLP structure was altered by co-expression of EBOV proteins leading t...

Reed F Johnson; Peter Bell; Ronald N Harty

2006-05-01T23:59:59.000Z

352

The role of mast cells in Theiler's virus-induced demyelination  

E-Print Network (OSTI)

Mast cells within the peripheral and central nervous systems of CBA and SJL mice during Theiler's virus-induced demyelination (TVID) have been investigated. CBA mice are intermediately susceptible and SJL mice are highly susceptible to TVIID...

Dean, Dana D

1997-01-01T23:59:59.000Z

353

Core Technology Analysis and Development for the Virus and Hacking Prevention  

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In this paper, we try to construct the searching and treatment modules to count the malignant programs effectively so that the Worm virus detection & blocking program has the functions thatit can check the fi...

Seung-Jae Yoo

2005-01-01T23:59:59.000Z

354

Hepatitis C Virus Network Based Classification of Hepatocellular Cirrhosis and Carcinoma  

E-Print Network (OSTI)

Hepatitis C virus (HCV) is a main risk factor for liver cirrhosis and hepatocellular carcinoma, particularly to those patients with chronic liver disease or injury. The similar etiology leads to a high correlation of the ...

Huang, Tao

355

Autologous and Heterologous Neutralization Analyses of Primary Feline Immunodeficiency Virus Isolates  

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...Neutralization Analyses of Primary Feline Immunodeficiency Virus Isolates Daniela del Mauro Donatella Matteucci Simone Giannecchini Fabrizio Maggi Mauro Pistello Mauro Bendinelli Retrovirus Center and Virology Section, Department of Biomedicine, University...

Daniela del Mauro; Donatella Matteucci; Simone Giannecchini; Fabrizio Maggi; Mauro Pistello; Mauro Bendinelli

1998-03-01T23:59:59.000Z

356

Avian diversity and West Nile virus: testing associations between biodiversity and infectious disease risk  

Science Journals Connector (OSTI)

...Kramer2003Serologic evidence of West Nile virus transmission, Jamaica, West Indies. Emerg. Infect. Dis...disease vectors in the Paraba Valley region, state of Sao Paulo...28, 74-78. Hayes, C.G West Nile fever. In Arboviruses...

2006-01-01T23:59:59.000Z

357

Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes.  

Science Journals Connector (OSTI)

...grant from the Department of Energy, Bioscience Division. Picor...differences in the binding free energies of human immunodeficiency virus...Eddy, S. J. Shin, R. L. Sheets, and J. H. Strauss. 1985...Close structural resem- blance between putative polymerase...

W G Dougherty; B L Semler

1993-12-01T23:59:59.000Z

358

Quantitatively Depositing Viruses onto TEM Grids Jennifer Brum, Tucson Marine Phage Lab  

E-Print Network (OSTI)

1 Quantitatively Depositing Viruses onto TEM Grids Jennifer Brum, Tucson Marine Phage Lab April prevents wear caused by metal-on-metal grinding) a) put a tiny amount of Spinkote on a Kimwipe b) rub

Sullivan, Matthew B.

359

Encapsidation of Host-Derived Factors Correlates with Enhanced Infectivity of Sindbis Virus  

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...The structure of Sindbis virus produced from vertebrate and invertebrate hosts as determined by small-angle neutron scattering. J. Virol. 84 :5270-5276. 28. Kostyuchenko, VA , J Jakana, X Liu, AD Haddow, M Aung, SC Weaver, W...

Kevin J. Sokoloski; Anthony J. Snyder; Natalia H. Liu; Chelsea A. Hayes; Suchetana Mukhopadhyay; Richard W. Hardy

2013-09-04T23:59:59.000Z

360

West Nile virus in the New World: potential impacts on bird species  

E-Print Network (OSTI)

The past five years have seen the arrival and extremely rapid expansion of West Nile virus (WNV) in the Western Hemisphere. The rapid sweep across North America has permitted little time for developing knowledge of the ...

Peterson, A. Townsend; Komar, Nicholas; Komar, Oliver; Navarro-Sigü enza, Adolfo G.; Robbins, Mark B.; Martí nez-Meyer, Enrique

2004-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

E-Print Network 3.0 - alfalfa mosaic virus Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

of the Brome Mosaic Virus Movement Protein Expressed in E. coli Kitty A. J. Jansen,* Cor J. A. M. Wolfs, Hendrikus Lohuis,* Rob W. Goldbach,* and Benedictus J. M....

362

Influenza A (H15N4) Virus Isolation in Western Siberia, Russia  

Science Journals Connector (OSTI)

...H15N4) Virus Isolation in Western Siberia, Russia Mariya V. Sivay a b Tatiana Baranovich c...Biotechnology Novosibirsk Region, Koltsovo, Russia b Novosibirsk State University, Novosibirsk, Russia c Department of Infectious Diseases, St...

Mariya V. Sivay; Tatiana Baranovich; Vasiliy Y. Marchenko; Kirill A. Sharshov; Elena A. Govorkova; Aleksander M. Shestopalov; Richard J. Webby

2013-01-02T23:59:59.000Z

363

Genetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Russia  

Science Journals Connector (OSTI)

...Crimean-Congo Hemorrhagic Fever Virus in Russia Lyudmila Yashina 1 Oleg Vyshemirskii 2...Koltsovo, Novosibirsk Region, 630559, Russia. Phone: 7 (383-2) 36-74-39...of Virology, RAMS, Moscow, 123098, Russia 3 Vanderbilt University Medical Center...

Lyudmila Yashina; Oleg Vyshemirskii; Sergei Seregin; Irina Petrova; Evgeny Samokhvalov; Dmitry Lvov; Valery Gutorov; Irina Kuzina; Georgy Tyunnikov; Yi-Wei Tang; Sergei Netesov; Vladimir Petrov

2003-02-01T23:59:59.000Z

364

Detection of Human Food-Borne and Zoonotic Viruses on Irrigated, Field-Grown Strawberries  

Science Journals Connector (OSTI)

...mulch and irrigation method) on strawberry viral contamination. Other factors not measured in this study (soil, wind, wildlife, etc.) could have played a role in viruses spreading in the plots. The fruits were not in contact with manures...

Julie Brassard; Marie-Jose Gagn; Mylne Gnreux; Caroline Ct

2012-03-16T23:59:59.000Z

365

Detection of chikungunya virus antigen by a novel rapid immunochromatographic test.  

Science Journals Connector (OSTI)

...by a novel rapid immunochromatographic test. Tamaki Okabayashi 1 6 * Tadahiro Sasaki...develop a new immunochromatographic diagnosis test for detection of chikungunya virus antigen...monoclonal antibodies, a new diagnostic test was developed and evaluated for the detection...

Tamaki Okabayashi; Tadahiro Sasaki; Promsin Masrinoul; Nantarat Chantawat; Sutee Yoksan; Narong Nitatpattana; Sarunyou Chusri; Ronald E. Morales Vargas; Marc Grandadam; Paul Brey; Soegeng Soegijanto; Kris Cahyo Mulyantno; Siti Churrotin; Tomohiro Kotaki; Oumar Faye; Ousmane Faye; Abdourahmane Sow; Amadou Alpha Sall; Orapim Puiprom; Panjaporn Chaichana; Takeshi Kurosu; Seiji Kato; Mieko Kosaka; Pongrama Ramasoota; Kazuyoshi Ikuta

2014-11-19T23:59:59.000Z

366

Hepatitis C virus prevalence and genetic diversity among pregnant women in Gabon, central Africa  

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Hepatitis C virus (HCV) infection is a major global public health problem in both developed and developing countries. The prevalence and genetic diversity of HCV in pregnant women in Gabon, central Africa, is not...

Guy-Roger Ndong-Atome; Maria Makuwa; Richard Njouom

2008-06-01T23:59:59.000Z

367

Cross-Species Transmission of Simian Foamy Virus to Humans in Rural Gabon, Central Africa  

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...of Simian Foamy Virus to Humans in Rural Gabon, Central Africa Augustin Mouinga-Ondeme...Medicales de Franceville, Franceville, Gabon b Unite des Maladies Virales Emergentes...Medicales de Franceville, Franceville, Gabon c Tulane National Primate Research Center...

Augustin Mouinga-Ondm; Mlanie Caron; Dieudonn Nkogh; Paul Telfer; Preston Marx; Ali Sab; Eric Leroy; Jean-Paul Gonzalez; Antoine Gessain; Mirdad Kazanji

2011-11-09T23:59:59.000Z

368

First serological evidence of West Nile virus in human rural populations of Gabon  

Science Journals Connector (OSTI)

To investigate West Nile virus (WNV) circulation in rural populations in Gabon, we undertook a large serological survey focusing ... findings strongly suggest that WNV is widespread in Gabon. The difference in WN...

Xavier Pourrut; Dieudonn Nkogh; Janusz Paweska; Eric Leroy

2010-06-01T23:59:59.000Z

369

E-Print Network 3.0 - al virus sincitial Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Search Powered by Explorit Topic List Advanced Search Sample search results for: al virus sincitial Page: << < 1 2 3 4 5 > >> 1 Temporal trends in the discovery of human...

370

E-Print Network 3.0 - al virus leucemia Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Search Powered by Explorit Topic List Advanced Search Sample search results for: al virus leucemia Page: << < 1 2 3 4 5 > >> 1 EnfErmEdadEs dEl jaguar En Estado silvEstrE...

371

Spatial analysis of West Nile Virus and predictors of hyperendemicity in the Texas equine industry  

E-Print Network (OSTI)

West Nile Virus (WNV) first appeared in Texas equids during June 2002. It has since spread rapidly across the state and apparently become endemic. Data from outbreaks occurring between 2002 and 2004 were analyzed to determine hotspots of equine WNV...

Wittich, Courtney Anne

2009-05-15T23:59:59.000Z

372

M13 Virus based detection of bacterial infections in living hosts  

E-Print Network (OSTI)

We report a first method for using M13 bacteriophage as a multifunctional scaffold for optically imaging bacterial infections in vivo. We demonstrate that M13 virus conjugated with hundreds of dye molecules (M13-Dye) can ...

Ghosh, Debadyuti

373

Extensive investigation of reticuloendotheliosis virus in the endangered Attwater's prairie chicken  

E-Print Network (OSTI)

to the repopulation of the Attwater's prairie chicken. Several aspects of virus infection were investigated. Reagents capable of recognizing prairie chicken IgY and viral gag polypeptides were developed for use in assays for detection of antibody responses...

Bohls, Ryan Lanier

2007-09-17T23:59:59.000Z

374

E-Print Network 3.0 - andes virus chi-7913 Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

and Ecology 20 1074 PHYTOPATHOLOGY Genetics and Resistance Summary: : Resistance to Potato virus Y in Wild Relatives of the Cultivated Potato X. K. Cai, D. M. Spooner, and S....

375

E-Print Network 3.0 - adeno-associated virus gene Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

(AAV) for expressing short hairpin RNA (sh... the human immunodeficiency virus type 1 (HIV-1) tat gene and the NF-B p65 subunit, respectively. 23 adeno-associated... 23...

376

V-101: McAfee VirusScan Enterprise Lets Local Users Gain Elevated...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

McAfee VirusScan Enterprise Lets Local Users Gain Elevated Privileges PLATFORM: VSE 8.8 Patch 2 with Access Protection, including Self Protection, turned off ABSTRACT: A...

377

Hepatitis C virus infection in injection drug users in Bavaria: Risk factors for seropositivity  

Science Journals Connector (OSTI)

Background: Hepatitis C Virus (HCV) infection is the most common disease among intravenous drug users (IDUs). Patients and method: All patients admitted to the detoxification unit 19911997 and m...

Markus Backmund; Kirsten Meyer; Martin Wchtler

2003-06-01T23:59:59.000Z

378

Investigation of the biological characteristics of amantadine-resistant influenza A virus  

E-Print Network (OSTI)

. . . . . The M2 Protein. . M2 and Amantadine Resistance. Amantadine Resistance in Clinical Isolates. . Amantadine Resistant Strains versus Sensitive Strains. . . . . . . . . Objectives. 2 5 6 9 11 14 17 MATERIALS AND METHODS. Cell Line and Virus.... . . . . The M2 Protein. . M2 and Amantadine Resistance. Amantadine Resistance in Clinical Isolates. . Amantadine Resistant Strains versus Sensitive Strains. . . . . . . . . Objectives. 2 5 6 9 11 14 17 MATERIALS AND METHODS. Cell Line and Virus...

Walters, Carol Christine

2012-06-07T23:59:59.000Z

379

Epstein-Barr virus immediate-early gene product trans-activates gene expression from the human immunodeficiency virus long terminal repeat  

SciTech Connect

Acquired immunodeficiency syndrome patients are frequently coinfected with Epstein-Barr virus (EBV). In this report, the authors demonstrate that an EBV immediate-early gene product, BamHI MLF1, stimulates expression of the bacterial chloramphenicol acetyltransferase (CAT) gene linked to the human immunodeficiency virus (HIV) promoter. The HIV promoter sequences necessary for trans-activation by EBV do not include the tat-responsive sequences. In addition, in contrast to the other herpesvirus trans-activators previously studied, the EBV BamHI MLF1 gene product appears to function in part by a posttranscriptional mechanism, since it increases pHIV-CAT protein activity more than it increases HIV-CAT mRNA. This ability of an EBV gene product to activate HIV gene expression may have biologic consequences in persons coinfected with both viruses.

Kenney, S.; Kamine, J.; Markovitz, D.; Fenrick, R.; Pagano, J.

1988-03-01T23:59:59.000Z

380

Structure of the Ebola Virus Glycoprotein Bound to an Antibody from a Human  

NLE Websites -- All DOE Office Websites (Extended Search)

Structure of the Ebola Virus Glycoprotein Bound to an Antibody from a Human Survivor Print Structure of the Ebola Virus Glycoprotein Bound to an Antibody from a Human Survivor Print Ebolavirus, one of two members of the family of filoviruses, causes a severe hemorrhagic fever with 50-90% human mortality. That no vaccines or treatments are yet available combined with the frequent re-emergence of the virus, its high prevalence among wildlife, and ease of importation of the virus make it a significant public health concern. A team of researchers from the Scripps Research Institute, using diffraction data collected at ALS Beamline 5.0.2, has recently determined the crystal structure of an oligomeric glycoprotein from the viral surface in complex with a rare antibody derived from a human survivor. This work explains how the glycoprotein, termed GP, mediates recognition of the host cell, drives fusion of the viral and host membranes (necessary for viral entry into the host), and masks itself from immune surveillance. The structure also explains why antibodies that neutralize the virus are so rare, identifies the very few sites to which a neutralizing antibody might bind, and thus, provides templates for vaccines and antibodies against the virus.

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Structure of a Venezuelan equine encephalitis virus assembly intermediate isolated from infected cells  

SciTech Connect

Venezuelan equine encephalitis virus (VEEV) is a prototypical enveloped ssRNA virus of the family Togaviridae. To better understand alphavirus assembly, we analyzed newly formed nucleocapsid particles (termed pre-viral nucleocapsids) isolated from infected cells. These particles were intermediates along the virus assembly pathway, and ultimately bind membrane-associated viral glycoproteins to bud as mature infectious virus. Purified pre-viral nucleocapsids were spherical with a unimodal diameter distribution. The structure of one class of pre-viral nucleocapsids was determined with single particle reconstruction of cryo-electron microscopy images. These studies showed that pre-viral nucleocapsids assembled into an icosahedral structure with a capsid stoichiometry similar to the mature nucleocapsid. However, the individual capsomers were organized significantly differently within the pre-viral and mature nucleocapsids. The pre-viral nucleocapsid structure implies that nucleocapsids are highly plastic and undergo glycoprotein and/or lipid-driven rearrangements during virus self-assembly. This mechanism of self-assembly may be general for other enveloped viruses.

Lamb, Kristen; Lokesh, G.L. [Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555-0647 (United States); Sherman, Michael [Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555-0647 (United States); W.M. Keck Center for Virus Imaging, University of Texas Medical Branch, Galveston, TX 77555-0647 (United States); Watowich, Stanley, E-mail: watowich@xray.utmb.ed [Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555-0647 (United States); W.M. Keck Center for Virus Imaging, University of Texas Medical Branch, Galveston, TX 77555-0647 (United States)

2010-10-25T23:59:59.000Z

382

One-step synthesis of efficient binding-inhibitor for influenza virus through multiple addition of sialyloligosaccharides on chitosan  

Science Journals Connector (OSTI)

We have succeeded in one-step synthesis of an efficient binding-inhibitor for influenza virus, which is composed of only sugar chains. This binding-inhibitor utilizes the carbohydrate recognition of influenza virus, thus it can prevent the virus from infection. We modified chitosan with multiple sialyl saccharides, ?2,6-sialyllactose or free sialyl glycan, using reductive amination reaction. The resulting inhibitors showed sufficient inhibitory activity against influenza virus infection in MDCK cells compared to that of ?2,6-sialyllactose or free sialyl glycan. Unlike the other binding-inhibitors of influenza virus, this virus inhibitor of sugar chains requires only one step in its synthesis. Therefore this inhibitor is suitable for use in products such as filters and masks.

Myco Umemura; Yutaka Makimura; Masae Itoh; Takeshi Yamamoto; Toshiki Mine; Seiji Mitani; Ichiro Simizu; Hisashi Ashida; Kenji Yamamoto

2010-01-01T23:59:59.000Z

383

Expression of Friend Leukemia Virus and Spleen Focus-forming Virus-specific Sequences in Erythroid Bursts and Granulocyte-Macrophage Colonies from Spleen and Marrow of Mice Infected with Friend Leukemia Virus  

Science Journals Connector (OSTI)

...passaged in our laboratory. Virus stock titers were, for FVP and FVA...macrophage colony- forming units colonies were separately pooled...The difference is also in keeping with kinetic data on the early...Mature erythroid burst-forming units are target cells for Friend...

Giulia Colletta; Pier Paolo Di Flore; Alfredo Fusco; Federico Lettieri; Alfredo Covelli; and Cesare Peschle

1983-02-01T23:59:59.000Z

384

What You Need To Know  

NLE Websites -- All DOE Office Websites (Extended Search)

What You Need to Know What You Need to Know An influenza (flu) pandemic is a worldwide outbreak of flu disease that occurs when a new type of influenza virus appears that people have not been exposed to before (or have not been exposed to in a long time). The pandemic virus can cause serious illness because people do not have immunity to the new virus. Pandemics are different from seasonal outbreaks of influenza that we see every year. Seasonal influenza is caused by influenza virus types to which people have already been exposed. Its impact on society is less severe than a pandemic, and influenza vaccines (flu shots and nasal-spray vaccine) are available to help prevent widespread illness from seasonal flu. Influenza pandemics are different from many of the other major public health and health care threats facing our country and the world. A pandemic will last much longer than most flu outbreaks and may include "waves" of influenza activity that last 6-8 weeks separated by months. The number of health care workers and first responders able to work may be reduced. Public health officials will not know how severe a pandemic will be until it begins.

385

Effective contact of cattle and feral swine facilitating potential foot-and-mouth disease virus transmission in southern Texas, USA rangeland  

E-Print Network (OSTI)

(1971). Probability of viral transmission is enhanced by: ?1) the amounts of virus given out by the infected animal; 2) the survival of virus outside the animal; and 3) the amount of virus required to set up disease in the susceptible animal... (1971). Probability of viral transmission is enhanced by: ?1) the amounts of virus given out by the infected animal; 2) the survival of virus outside the animal; and 3) the amount of virus required to set up disease in the susceptible animal...

De La Garza, Guadalupe Ray, III

2009-05-15T23:59:59.000Z

386

Caractrisation d'une nouvelle souche du virus du fltrissement de la fve isole de l'artichaut  

E-Print Network (OSTI)

° 256, Université de Rennes I, F35042 Rennes Cedex R?SUM? Un virus isolé de l'artichaut « Camus de in France. A virus isolated from artichoke "Camus de Bretagne" in France has been characterized biologically « Camus de Bretagne» (MIGLIORI et al., 1987). Deux virus sur les 6 observés sont fréquents ; il s'agit d

Paris-Sud XI, Université de

387

A Historical Perspective and Review of the Evidence to Support Fruit Bats as the Natural Reservoir for Ebola Viruses.  

E-Print Network (OSTI)

?? The Ebola viruses cause sporadic outbreaks of Ebola hemorrhagic fever (EHF) where origins have been traced to the continent of Africa and the Philippines. (more)

Reed, Zachary

2012-01-01T23:59:59.000Z

388

A study of the Ebola virus glycoprotein: Disruption of host surface protein function and evasion of immune responses.  

E-Print Network (OSTI)

??The Ebola virus (EBOV) is a member of the family, Filoviridae, and is the etiological agent of Ebola hemorrhagic fever (EHF). This disease causes significant (more)

Francica, Joseph R

2010-01-01T23:59:59.000Z

389

Function of the Viral Matrix Proteins VP40 and VP24 for the Life Cycle of Ebola Virus.  

E-Print Network (OSTI)

??Ebola virus (EBOV), a member of the family Filoviridae in the order Mononegavirales, is the causative agent of a severe haemorrhagic fever. Due to its (more)

Hoenen, Thomas

2007-01-01T23:59:59.000Z

390

The Structure of a T=169d Algal Virus, PBCV-1, at 15 Resolution ** V. Bowman,* N. H. Olson,*,  

E-Print Network (OSTI)

Pathology, University of Nebraska, Lincoln, NE 68583-0722 Paramecium bursaria chlorella virus 1 (PBCV-1) (genus Chlorovirus, family Phycodnaviridae), infects certain unicellular, exsymbiotic, chlorella

Baker, Timothy S.

391

Osteoblasts from osteoarthritis patients show enhanced susceptibility to Ross River virus infection associated with delayed type I interferon responses  

Science Journals Connector (OSTI)

Osteoblasts from osteoarthritis patients show enhanced susceptibility to Ross River virus infection, indicating osteoarthritis as a risk factor for alphavirus-induced bone pathology.

Weiqiang Chen; Suan-Sin Foo; Rachel W Li; Paul N Smith; Suresh Mahalingam

2014-11-19T23:59:59.000Z

392

Fusion properties of cells infected with human parainfluenza virus type 3: receptor requirements for viral spread and virus-mediated membrane fusion.  

Science Journals Connector (OSTI)

...requirements for mediating fusion. The envelope of...parainfluenza virus type 3 (HPF3) contains...extensive cell fusion was evident in both cell types at both MOIs. In...for F to mediate fusion, and only the type-matched HN can...

A Moscona; R W Peluso

1992-11-01T23:59:59.000Z

393

Differences and Similarities in Viral Life Cycle Progression and Host Cell Physiology after Infection of Human Dendritic Cells with Modified Vaccinia Virus Ankara and Vaccinia Virus  

Science Journals Connector (OSTI)

...recombinant vaccinia virus vectors. Gene 142: 167-174. 12 Bronte, V., M. W. Carroll, T. J. Goletz, M. Wang, W. W. Overwijk, F. Marincola, S. A. Rosenberg, B. Moss, and N. P. Restifo. 1997. Antigen expression by dendritic cells correlates...

Ann Chahroudi; David A. Garber; Patrick Reeves; Luzheng Liu; Daniel Kalman; Mark B. Feinberg

2006-09-01T23:59:59.000Z

394

Jembrana Disease Virus Tat Can Regulate Human Immunodeficiency Virus (HIV) Long Terminal Repeat-Directed Gene Expression and Can Substitute for HIV Tat in Viral Replication  

Science Journals Connector (OSTI)

...Expression and Can Substitute for HIV Tat in Viral Replication Hexin Chen Jun...virus (HIV) LTR. In contrast, HIV Tat cannot reciprocally activate the JDV...to but not the same as that of the HIV Tat. To further study the similarity...

Hexin Chen; Jun He; Steven Fong; Graham Wilcox; Charles Wood

2000-03-01T23:59:59.000Z

395

The N Terminus of the Influenza B Virus Nucleoprotein Is Essential for Virus Viability, Nuclear Localization, and Optimal Transcription and Replication of the Viral Genome  

Science Journals Connector (OSTI)

...replication. MATERIALS AND METHODS Cell and viruses. 293T and MDCK cells were maintained in Dulbecco's modified Eagle's medium (DMEM) (Invitrogen) supplemented with 10% fetal calf serum (FCS) at 37C with 5% CO2. B/Yamanashi/98 wild-type...

Lee Sherry; Matt Smith; Sophie Davidson; David Jackson

2014-08-13T23:59:59.000Z

396

Role of the Specific Amino Acid Sequence of the Membrane-Spanning Domain of Human Immunodeficiency Virus Type 1 in Membrane Fusion  

Science Journals Connector (OSTI)

...Human Immunodeficiency Virus Type 1 in Membrane Fusion Kosuke Miyauchi 1 Jun Komano...particularly in membrane fusion, by making two types of MSD mutants: (i) glycine...human immunodeficiency virus type 1 in membrane fusion. | Fusion between cell...

Kosuke Miyauchi; Jun Komano; Yoshiyuki Yokomaku; Wataru Sugiura; Naoki Yamamoto; Zene Matsuda

2005-04-01T23:59:59.000Z

397

Induction of ebolavirus cross-species immunity using retrovirus-like particles bearing the Ebola virus glycoprotein lacking the mucin-like domain  

Science Journals Connector (OSTI)

The genus Ebolavirus includes five distinct viruses. Four of these viruses cause hemorrhagic fever in humans. Currently there are no licensed vaccines for any of them; however, several vaccines are under developm...

Wu Ou; Josie Delisle; Jerome Jacques; Joanna Shih; Graeme Price

2012-01-01T23:59:59.000Z

398

Antibody Profiling by Proteome Microarray Reveals the Immunogenicity of the Attenuated Smallpox Vaccine Modified Vaccinia Virus Ankara Is Comparable to That of Dryvax  

Science Journals Connector (OSTI)

...generation of recombinant viruses in a nonhuman mammalian cell line. Virology 238: 198-211. 6 Carroll, M. W., W. W. Overwijk, R. S. Chamberlain, S. A. Rosenberg, B. Moss, and N. P. Restifo. 1997. Highly attenuated modified vaccinia virus...

D. Huw Davies; Linda S. Wyatt; Frances K. Newman; Patricia L. Earl; Sookhee Chun; Jenny E. Hernandez; Douglas M. Molina; Siddiqua Hirst; Bernard Moss; Sharon E. Frey; Philip L. Felgner

2007-10-31T23:59:59.000Z

399

Differential cytokine mRNA expression induced by binding of virulent and avirulent molecularly cloned equine infectious anemia viruses to equine macrophages  

E-Print Network (OSTI)

Equine infectious anemia virus (EIAV) causes rapid development of acute disease followed by recurring episodes of fever, thrombocytopenia and viremia, termed chronic EIA. Most infected horses control the virus by immune mechanisms and become...

Lim, Wah-Seng

2004-11-15T23:59:59.000Z

400

Sequence diversity of the nucleoprotein gene of iris yellow spot virus (genus Tospovirus, family Bunyaviridae) isolates from the western region of the United States  

Science Journals Connector (OSTI)

Iris yellow spot virus (IYSV), a tentative virus species in the genus Tospovirus and family Bunyaviridae, is considered a rapidly emerging threat to onion production in the western United States (US). The present...

H. R. Pappu; L. J. du Toit; H. F. Schwartz; S. K. Mohan

2006-05-01T23:59:59.000Z

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Identification and characterization of biologically distinct isolates of Iris yellow spot virus (genus Tospovirus, family Bunyaviridae), a serious pathogen of onion  

Science Journals Connector (OSTI)

Iris yellow spot virus (IYSV) causes an economically important disease in onion bulb and seed crops. While considerable information on the genetic diversity of the virus is available, little is k...

Sudeep Bag; H. F. Schwartz; H. R. Pappu

2012-09-01T23:59:59.000Z

402

Studies of Ebola Virus Glycoprotein-Mediated Entry and Fusion by Using Pseudotyped Human Immunodeficiency Virus Type 1 Virions: Involvement of Cytoskeletal Proteins and Enhancement by Tumor Necrosis Factor Alpha  

Science Journals Connector (OSTI)

...quantitative assay that detects the fusion of human immunodeficiency virus type 1 (HIV-1) virions to...2 required for entry and fusion of both types of the virions was shorter...human immunodeficiency virus type 1 fusion to virion maturation: a...

Akihito Yonezawa; Marielle Cavrois; Warner C. Greene

2005-01-01T23:59:59.000Z

403

The Crystal Structure of a Coxsackievirus B3-RD Variant and a Refined 9-Angstrom Cryo-Electron Microscopy Reconstruction of the Virus Complexed with Decay-Accelerating Factor (DAF) Provide a New Footprint of DAF on the Virus Surface  

Science Journals Connector (OSTI)

...features with the fitted crystal structure of the virus...from the newly solved crystal structure of the RD variant...the virus surface as a bent cylinder crossing in...graph describing the spherical average distribution...map calculated from the crystal structure (white) was...

Joshua D. Yoder; Javier O. Cifuente; Jieyan Pan; Jeffrey M. Bergelson; Susan Hafenstein

2012-09-12T23:59:59.000Z

404

A novel Ebola virus expressing luciferase allows for rapid and quantitative testing of antivirals  

Science Journals Connector (OSTI)

Abstract Ebola virus (EBOV) causes a severe hemorrhagic fever with case fatality rates of up to 90%, for which no antiviral therapies are available. Antiviral screening is hampered by the fact that development of cytopathic effect, the easiest means to detect infection with wild-type EBOV, is relatively slow. To overcome this problem we generated a recombinant EBOV carrying a luciferase reporter. Using this virus we show that EBOV entry is rapid, with viral protein expression detectable within 2h after infection. Further, luminescence-based assays were developed to allow highly sensitive titer determination within 48h. As a proof-of-concept for its utility in antiviral screening we used this virus to assess neutralizing antibodies and siRNAs, with significantly faster screening times than currently available wild-type or recombinant viruses. The availability of this recombinant virus will allow for more rapid and quantitative evaluation of antivirals against EBOV, as well as the study of details of the EBOV life cycle.

Thomas Hoenen; Allison Groseth; Julie Callison; Ayato Takada; Heinz Feldmann

2013-01-01T23:59:59.000Z

405

Activation of tat-defective human immunodeficiency virus by ultraviolet light  

SciTech Connect

Ultraviolet light (UV) is known to cause activation of gene expression from the human immunodeficiency virus type 1 (HIV-1) promoter. To address the question of whether tat-defective HIV-1 provirus could be rescued by UV irradiation we examined its effect on HeLa cells containing integrated proviruses with tat mutations. Exposure of these cells to an optimal dose of UV resulted in the production of infectious viruses. The degree of UV activation and reversion to infectious virus appeared to depend on the nature of the original tat mutation. Two of the mutants required cocultivation with tat-expressing cells to fully generate replication competent viruses, while a third mutant required only cocultivation with H9 cells. Sequencing of cDNA from cells infected with this last mutant demonstrated that the parental mutant sequence was retained and that genotypic revertants to the wild-type as well as new mutant sequences were generated. These results suggest that tat-defective HIV-1 provirus can be activated by UV and can subsequently revert to wild-type virus. This study raises the possibility that UV exposure of immune cells in the skin plays a role in the activation of defective HIV-1 in vivo.

Sadaie, M.R.; Tschachler, E.; Valerie, K.; Rosenberg, M.; Felber, B.K.; Pavlakis, G.N.; Klotman, M.E.; Wong-Staal, F. (National Institutes of Health, Bethesda, MD (USA))

1990-05-01T23:59:59.000Z

406

Cell-cell fusion induced by measles virus amplifies the type I interferon1 F. Herschke1  

E-Print Network (OSTI)

1 Cell-cell fusion induced by measles virus amplifies the type I interferon1 response2 3 F and $ These authors equally contributed to this work18 19 Running title: Amplified interferon by virus-induced fusion derived from human epithelial cells or mature conventional dendritic cells (mDC). Both33 fusion and IFN

Paris-Sud XI, Université de

407

DC-SIGN mediates avian H5N1 influenza virus infection in cis and in trans  

SciTech Connect

DC-SIGN, a C-type lectin receptor expressed in dendritic cells (DCs), has been identified as a receptor for human immunodeficiency virus type 1, hepatitis C virus, Ebola virus, cytomegalovirus, dengue virus, and the SARS coronavirus. We used H5N1 pseudotyped and reverse-genetics (RG) virus particles to study their ability to bind with DC-SIGN. Electronic microscopy and functional assay results indicate that pseudotyped viruses containing both HA and NA proteins express hemagglutination and are capable of infecting cells expressing {alpha}-2,3-linked sialic acid receptors. Results from a capture assay show that DC-SIGN-expressing cells (including B-THP-1/DC-SIGN and T-THP-1/DC-SIGN) and peripheral blood dendritic cells are capable of transferring H5N1 pseudotyped and RG virus particles to target cells; this action can be blocked by anti-DC-SIGN monoclonal antibodies. In summary, (a) DC-SIGN acts as a capture or attachment molecule for avian H5N1 virus, and (b) DC-SIGN mediates infections in cis and in trans.

Wang, S.-F.; Huang, Jason C. [Department of Biotechnology and Laboratory Science in Medicine, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan (China); AIDS Prevention and Research Center, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan (China); Lee, Y.-M. [Division of Preventive Medicine, Institute of Public Health, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan (China); Division of Clinical Virology, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan (China); Liu, S.-J. [Vaccine Research and Development Center, National Health Research Institutes, Taiwan (China); Chan, Yu-Jiun [Division of Preventive Medicine, Institute of Public Health, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan (China); Division of Clinical Virology, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan (China); Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan (China); Chau, Y.-P. [Institute of Anatomy and Cell Biology, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan (China); Chong, P. [Vaccine Research and Development Center, National Health Research Institutes, Taiwan (China); Chen, Y.-M.A. [AIDS Prevention and Research Center, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan (China) and Division of Preventive Medicine, Institute of Public Health, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan (China); Department of Microbiology, School of Medicine, National Yang-Ming University, AIDS Prevention and Research Center, No. 155, Linong Street, Section 2, Taipei 112, Taiwan (China)], E-mail: arthur@ym.edu.tw

2008-09-05T23:59:59.000Z

408

JC virus quasispecies analysis reveals complex viral population underlying PML and supports viral dissemination via the hematogenous route  

Science Journals Connector (OSTI)

...virus sporadically can be identified in PML brain although selection of rearranged JC virus...following high level DNA replication in the brain underlying PML has hitherto been much underestimated...viral dissemination from or towards the brain. IMPORTANCE For the first time the JC...

Tom Van Loy; Kim Thys; Caroline Ryschkewitsch; Ole Lagatie; Maria C. Monaco; Eugene O. Major; Luc Tritsmans; Lieven J. Stuyver

2014-11-12T23:59:59.000Z

409

I Ph}",l. 28, 846-850 (1992) REPLICATION OF CHLORELLA VIRUS PBCV-l AND HOST KARYOTYPE  

E-Print Network (OSTI)

I Ph}",l. 28, 846-850 (1992) REPLICATION OF CHLORELLA VIRUS PBCV-l AND HOST KARYOTYPE DETERMINATION 97331-2902 ABSTRACT We demonstrated the time-courseojDNA rePlication of the 330-kbp Chlorella virus PBCV the sizes oj the bands predicts a genome size oj 39-45 Mbp afDNA. Key index words: Chlorella; Chloro

Graves, Michael V.

410

Iron Chloride Precipitation of Viruses from Seawater Revision: 25 Mar 2014 Tucson Marine Phage Lab Page 1 of 5  

E-Print Network (OSTI)

waters using iron- based flocculation and large-pore-size filtration, followed by resuspension of virus- containing precipitates in a pH 6 buffer. This Fe-based virus flocculation, filtration and resuspension in the resuspension buffer. Particles lose infectivity if resuspended with ascorbic acid in the buffer. PCR inhibition

Sullivan, Matthew B.

411

Attachment and survival of viruses on lettuce (Lactuca sativa L. var. capitata L.): role of physicochemical and biotic factors  

E-Print Network (OSTI)

. Salads and salad crops are the principal vector for transmission of enteric viruses. The objective of this study was to determine if viruses are able to attach non-specifically to the surface of lettuce and to determine the forces responsible for non...

Vega, Everardo

2006-10-30T23:59:59.000Z

412

Sites of copy choice replication involved in generation of vesicular stomatitis virus defective-interfering particle RNAs.  

Science Journals Connector (OSTI)

...Replication DNA Restriction Enzymes Defective Viruses genetics Genes, Viral...Vesicular Stomatitis Virus Defective-Interfering Particle RNAs...Celter, Diur liali,n Nor thl Car olina i 277102 Received 27...model for the generation of defective interfering (DI) particles...

E Meier; G G Harmison; J D Keene; M Schubert

1984-08-01T23:59:59.000Z

413

Newly Identified Phosphorylation Site in the Vesicular Stomatitis Virus P Protein Is Required for Viral RNA Synthesis  

Science Journals Connector (OSTI)

...stomatitis virus P and N proteins: identification of...Chandipura virus N and P proteins: identification of...phosphoprotein is globally disordered but contains transient alpha-helices. Protein Sci. 20 :542-556...and M Jamin. 2012. Ensemble structure of the modular...

Arindam Mondal; Ken G. Victor; R. S. Pudupakam; Charles E. Lyons; Gail W. Wertz

2013-11-20T23:59:59.000Z

414

Biochemistry 1995, 34, 4077-4087 4077 C2, an Unusual Filamentous Bacterial Virus: Protein Sequence and Conformation,  

E-Print Network (OSTI)

-fold screw, the symmetry being designated CsS-2. In class I1 viruses (Pf1, Xf, and PB), the protein helices have approximately 5.4-fold screw symmetry, nominally ClS-5.4. The subunits in successive levels and Day (1988)l. Such viruses are assembled at the host cell membrane as they are extruded into the medium

415

Effects of the tom1 mutation of Arabidopsis thaliana on the multiplication of tobacco mosaic virus RNA in protoplasts.  

Science Journals Connector (OSTI)

...multiplication of TMV in plants. For full accumulation of viral CP in upper uninoculated leaves, all the following processes must pro- ceed with normal efficiencies: invasion of virus particles into a cell, uncoating of virus particles to release bare genomic RNA...

M Ishikawa; S Naito; T Ohno

1993-09-01T23:59:59.000Z

416

Safety of prolonged administration of rimantadine hydrochloride in the prophylaxis of influenza A virus infections in nursing homes.  

Science Journals Connector (OSTI)

...influenza A virus infections in nursing homes. P A Patriarca N A Kater A P Kendal D...placebo-controlled trial in three nursing homes during a community epidemic of influenza...influenza A virus infections in nursing homes. | We evaluated the safety of rimantadine...

P A Patriarca; N A Kater; A P Kendal; D J Bregman; J D Smith; R K Sikes

1984-07-01T23:59:59.000Z

417

Nuclear Export Factor CRM1 Interacts with Nonstructural Proteins NS2 from Parvovirus Minute Virus of Mice  

Science Journals Connector (OSTI)

...CRM1 Interacts with Nonstructural Proteins NS2 from Parvovirus Minute Virus of Mice Ursula...dkfz-heidelberg.de. The nonstructural NS2 proteins of autonomous parvoviruses are...characterization of the interaction with the NS2 proteins from the parvovirus minute virus...

Ursula Bodendorf; Celina Cziepluch; Jean-Claude Jauniaux; Jean Rommelaere; Nathalie Salom

1999-09-01T23:59:59.000Z

418

Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2  

Science Journals Connector (OSTI)

... of peptides. a, Amino-acid sequence of the matrix protein13 using the single letter code for amino acids. The eight synthetic peptides made with an Applied Biosystems synthesizer are ... vaccinia virus (Ml-VACC), influenza non-structural protein-2 expressing recombinant vaccinia virus (NS2-VACC), uninfected (0), or were treated with the synthetic peptides shown. The ...

Frances Gotch; Jonathan Rothbard; Kevin Howland; Alain Townsend; Andrew McMichael

1987-04-30T23:59:59.000Z

419

HEPATITIS C VIRUS (HCV) PROTEINS INDUCE LIPOGENESIS AND DEFECTIVE TRIGLYCERIDE SECRETION IN TRANSGENIC MICE EXPRESSING THE HCV FULL-  

E-Print Network (OSTI)

1 HEPATITIS C VIRUS (HCV) PROTEINS INDUCE LIPOGENESIS AND DEFECTIVE TRIGLYCERIDE SECRETION, Université Paris 12, Créteil, France4 Running head: Lipogenesis and triglyceride secretion in HCV mice hepatitis C virus (HCV) infection is associated with altered lipid metabolism and hepatocellular steatosis

Paris-Sud XI, Université de

420

Inhibition of Ebola Virus Infection: Identification of Niemann-Pick C1 as the Target by Optimization of a Chemical Probe  

Science Journals Connector (OSTI)

Inhibition of Ebola Virus Infection: Identification of Niemann-Pick C1 as the Target by Optimization of a Chemical Probe ... A high-throughput screen identified adamantane dipeptide 1 as an inhibitor of Ebola virus (EboV) infection. ... Ebola virus; small molecule inhibitor; viral entry; photoaffinity label; target identification; Niemann-Pick C1 ...

Kyungae Lee; Tao Ren; Marceline Ct; Berahman Gholamreza; John Misasi; Anna Bruchez; James Cunningham

2012-12-15T23:59:59.000Z

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Synthetic Fusion Peptides of Tick-Borne Encephalitis Virus as Models for Membrane Fusion  

Science Journals Connector (OSTI)

Initial coordinates for the L107F and L107T mutants were generated by modifying residue 107 into the appropriate residue types using CHIMERA (57). ... The ability of human immunodeficiency virus type 1 (HIV-1) to fuse its membrane with the membrane of the target cell is a function of a ?23-amino-acid amino-terminal segment of the gp41 subunit of the envelope glycoprotein complex, known as the fusion peptide. ... At the optimum pH for fusion and 37, the rate and extent of fusion were very high, with >50% of the virus fusing within 2 s and the final extent of fusion being 70%. ...

Jinhe Pan; C. Benjamin Lai; Walter R. P. Scott; Suzana K. Straus

2009-12-10T23:59:59.000Z

422

NMR Structure, Localization, and Vesicle Fusion of Chikungunya Virus Fusion Peptide  

Science Journals Connector (OSTI)

(4, 5, 17, 18) The type I fusion proteins, observed in influenza virus, HIV and SARS virus, are typified by a trimeric assembly of ?-helical coiled coil hairpins in the postfusion state. ... Recombinant fusin enabled CD4-expressing nonhuman cell types to support HIV-1 Env-mediated cell fusion and HIV-1 infection. ... After exposure to acid pH in endosomal compartments, a viral glycoprotein with the potential to mediate fusion undergoes a conformational change with the result that the viral envelope fuses with the endosomal membrane. ...

Harini Mohanram; Alyssa Nip; Prerna N Domadia; Anirban Bhunia; Surajit Bhattacharjya

2012-09-14T23:59:59.000Z

423

Identification and characterization of a virus isolated from bobwhite quail with a respiratory disease  

E-Print Network (OSTI)

. Observations were made on the chicken embryo mortality pat- tern, dwarfing and the gross lesions of necropsicd embryos in the reisolations of;"QV and CZLO virus, tne filtration of CZLO virus, in straight passages (/th through lith) of 2 field strains 17... and 8 days after inoculation in CELO Group I. It was usually unilateral and usually, but not clways, on the side of the intraocular inoculation. Nasal discharge could not, be di. s- cerned while the quail were in the 'brooder. Respiratory symptoms in:QV...

DuBose, Robert Trafton

2012-06-07T23:59:59.000Z

424

Characterization of a virus associated with head and lateral line erosion syndrome (HLLE) in marine angelfish  

E-Print Network (OSTI)

culture infective dose (TCIDss) method of determination as outlined by Rovozzo and Burke (1973). Virus titers were determined following 10-fold serial dilutions on RFDF monolayers in tissue culture chamber slides (Lab-Tek, Nunc, Inc. , Naperville, Il... model L-2 ultracentrifuge for 1. 5 hr using a swing-bucket type rotor (SW41 or SW28). The virus pellet was resuspended in 1 ml TNE buffer (0. 025 M Tris [Mallinckrodt, Paris, KY, USA], 0. 1 M NaCl, 1mM EDTA [Sigma Chemical Co. , St. Louis, MO, USA], p...

Varner, Patricia Wilcox

2012-06-07T23:59:59.000Z

425

Isolation methods and electron microscopy of the Internal Cork Virus of sweet potatoes  

E-Print Network (OSTI)

of the Virus Within the Cells of a Lesion from a Tuber 2 20 A lesion from a tuber was cut into cubes about one-half millimeter on an edge. Half of the cubes were fixed in buffered osmic acid and the other half were fixed in potassium permanganate solution... of the Virus Within the Cells of a Lesion from a Tuber 2 20 A lesion from a tuber was cut into cubes about one-half millimeter on an edge. Half of the cubes were fixed in buffered osmic acid and the other half were fixed in potassium permanganate solution...

Pickens, Edgar Eugene

2012-06-07T23:59:59.000Z

426

Hepatitis C virus genotypes and co-infection with GB virus C in patients with anti-HCV-positive chronic liver disease in Jakarta, Indonesia  

Science Journals Connector (OSTI)

Of 153 patients with chronic liver disease in Jakarta, Indonesia, who were positive for antibody to hepatitis C virus (HCV), 129 (84%) had HCV RNA in serum. HCV genotypes were II/1b in 55 (43%), III/2a in 33 (26%) and 1c in 15 (12%) patients; genotypes were not classifiable into the common five (I/1a, II/1b, III/2a, IV/2b and V/3a) or 1 c in the remaining 25 (19%) patients. RNA of a putative non-A-E hepatitis virus, designated GB virus C (GBV-C), was tested for by reverse-transcription polymerase chain reaction with nested primers deduced from the 5?-noncoding region, and detected in 18 (12%) patients of whom 14 (78%) possessed serum HCV RNA. These results indicate that 1c and the other indigenous genotypes of HCV, as well as the co-infection with GBV-C, would be common among Indonesian patients with HCV-associated chronic liver disease.

Laurentius A. Lesmana; H.Ali Sulaiman; H.M. Sjaifoellah Noer; Fumio Tsuda; Hiroaki Okamoto

1996-01-01T23:59:59.000Z

427

Identification of full-length transmitted/founder viruses and their progeny in primary HIV-1 infection  

SciTech Connect

Identification of transmitted/founder virus genomes and their progeny by is a novel strategy for probing the molecular basis of HIV-1 transmission and for evaluating the genetic imprint of viral and host factors that act to constrain or facilitate virus replication. Here, we show in a cohort of twelve acutely infected subjects (9 clade B; 3 clade C), that complete genomic sequences of transmitted/founder viruses could be inferred using single genome amplification of plasma viral RNA, direct amplicon sequencing, and a model of random virus evolution. This allowed for the precise identification, chemical synthesis, molecular cloning, and biological analysis of those viruses actually responsible for productive clinical infection and for a comprehensive mapping of sequential viral genomes and proteomes for mutations that are necessary or incidental to the establishment of HIV-1 persistence. Transmitted/founder viruses were CD4 and CCR5 tropic, replicated preferentially in activated primary T-Iymphocytes but not monocyte-derived macrophages, and were effectively shielded from most heterologous or broadly neutralizing antibodies. By 3 months of infection, the evolving viral quasispecies in three subjects showed mutational fixation at only 2-5 discreet genomic loci. By 6-12 months, mutational fixation was evident at 18-27 genomic loci. Some, but not all, of these mutations were attributable to virus escape from cytotoxic Tlymphocytes or neutralizing antibodies, suggesting that other viral or host factors may influence early HIV -1 fitness.

Korber, Bette [Los Alamos National Laboratory; Hraber, Peter [Los Alamos National Laboratory; Giorgi, Elena [Los Alamos National Laboratory; Bhattacharya, T [Los Alamos National Laboratory

2009-01-01T23:59:59.000Z

428

Integrating genetic and epidemiological data to determine transmission pathways of foot-and-mouth disease virus  

Science Journals Connector (OSTI)

...farms. The study has demonstrated the power of forensic genetic tracing for FMDV...Organization World Reference Laboratory for Foot-and-Mouth Disease. We are grateful...and cattle experimentally infected with foot-and-mouth disease virus O UK 2001...

2008-01-01T23:59:59.000Z

429

Regulation of Human Immunodeficiency Virus Type 1 Env-Mediated Membrane Fusion by Viral Protease Activity  

Science Journals Connector (OSTI)

...Regulation of Human Immunodeficiency Virus Type 1 Env-Mediated Membrane Fusion by Viral Protease Activity Tsutomu Murakami...HIV-1 virions to induce cell-to-cell fusion, a type of fusion known as fusion from without (3, 11, 28...

Tsutomu Murakami; Sherimay Ablan; Eric O. Freed; Yuetsu Tanaka

2004-01-01T23:59:59.000Z

430

Risk Assessment of H2N2 Influenza Viruses from the Avian Reservoir  

Science Journals Connector (OSTI)

...variations between the in vitro and in vivo models highlight the notion that there is no universal model that can precisely predict influenza virus fitness in humans...should include a variety of available model systems. To summarize the data generated...

Jeremy C. Jones; Tatiana Baranovich; Bindumadhav M. Marathe; Angela F. Danner; Jon P. Seiler; John Franks; Elena A. Govorkova; Scott Krauss; Robert G. Webster

2013-11-13T23:59:59.000Z

431

Quantitative analysis of virus and plasmid trafficking in cells Thibault Lagache, Emmanuel Dauty  

E-Print Network (OSTI)

Intracellular transport of DNA carriers is a fundamental step of gene delivery. By combining both theoretical, the geometry of cell and nucleus, the number and sizes of nuclear pores, the various degradation factors to be necessary in the case of viruses. A recent study [8] showed that microtubules shape the distribution

Lagache, Thibault

432

Primary Human Macrophages Serve as Vehicles for Vaccinia Virus Replication and Dissemination  

Science Journals Connector (OSTI)

...UV-inactivated, recombinant EBNA-3A vaccinia virus. Blood 94 :1372-1381. 16. Bronte, V , MW Carroll, TJ Goletz, M Wang, WW Overwijk, F Marincola, SA Rosenberg, B Moss, and NP Restifo. 1997. Antigen expression by dendritic cells correlates with the therapeutic...

Daniel Byrd; Nicole Shepherd; Jie Lan; Ningjie Hu; Tohti Amet; Kai Yang; Mona Desai; Qigui Yu

2014-04-02T23:59:59.000Z

433

Influenza Virus-Membrane Fusion Triggered by Proton Uncaging for Single Particle Studies of Fusion Kinetics  

E-Print Network (OSTI)

and Engineering, Cornell University, Ithaca, New York, United States � School of Applied and Engineering Physics parameters obtained from the data are sensitive to the rate at which protons are delivered to the bound with the endosomal membrane to pass viral genetic material into the cytosol. For many enveloped viruses, a drop

Daniel, Susan

434

Synthesis of Subgenomic RNAs by Positive-Strand RNA Viruses W. Allen Miller1  

E-Print Network (OSTI)

MINIREVIEW Synthesis of Subgenomic RNAs by Positive-Strand RNA Viruses W. Allen Miller1 is required for sgRNA synthesis, the RNA-dependent RNA polymerase (RdRp) is always translated first, directly, Tymovirus, Potexvirus, Hordeivirus, Tobamovirus, Sobemovirus, and Furovirus genera. Subgenomic RNA synthesis

Miller, W. Allen

435

Synthesis of Large Dendrimers with the Dimensions of Small Viruses Jongdoo Lim,  

E-Print Network (OSTI)

Synthesis of Large Dendrimers with the Dimensions of Small Viruses Jongdoo Lim, Mauri Kostiainen of growth per synthetic cycle. Fidelity in the synthesis is supported by evidence from NMR spectroscopy of this length scale are a convergent point for both top-down and bottom-up synthesis. Existing organic building

Annunziata, Onofrio

436

Peromyscus maniculatus in eastern Colorado: a subspecies with lower prevalence of Sin Nombre virus infection  

E-Print Network (OSTI)

a significantly lower Sin Nombre virus (SNV) antibody prevalence than mice from western Colorado. Based the mountainous regions of western Colorado and clade 2 crosses the short-grass steppe in southeastern Colorado differentiation was detected (FST 5 0.027) among 435 deer mice collected from 8 locations in western Colorado

437

Nuclear import of hepatitis B virus capsids and release of the viral genome  

E-Print Network (OSTI)

Nuclear import of hepatitis B virus capsids and release of the viral genome Birgit Rabe*, Angelika through the nuclear pore into the nuclear basket. Import depended on phosphorylation of the capsid protein from the inner face of the nuclear pore. Immature capsids that did not contain the mature viral genome

Panté, Nelly

438

Confirmed speakers include: THE GLOBAL ROLE OF VIRUSES IN BLOOM TERMINATION, BIODIVERSITY AND MARINE ECOLOGY  

E-Print Network (OSTI)

IN BLOOM TERMINATION, BIODIVERSITY AND MARINE ECOLOGY GUNNAR BRATBAK ­ University of Bergen, NorwayConfirmed speakers include: THE GLOBAL ROLE OF VIRUSES IN BLOOM TERMINATION, BIODIVERSITY AND MARINE ECOLOGY GUNNAR BRATBAK ­ University of Bergen, Norway COLLECTION, PROCESSING AND PRESERVATION

Wilhelm, Steven W.

439

BAG3, a Host Cochaperone, Facilitates Varicella-Zoster Virus Replication  

Science Journals Connector (OSTI)

...geldanamycin treatment prevented nuclear localization of ORF29p in MeWo...treatment. To demonstrate that nuclear exclusion resulting from drug-induced...knockdown of BAG3 does not block nuclear accumulation of virus and host...replication bodies but at the cost of a dramatically slowed and...

Christos A. Kyratsous; Saul J. Silverstein

2007-05-02T23:59:59.000Z

440

Lung Irradiation Increases Mortality After Influenza A Virus Challenge Occurring Late After Exposure  

SciTech Connect

Purpose: To address whether irradiation-induced changes in the lung environment alter responses to a viral challenge delivered late after exposure but before the appearance of late lung radiation injury. Methods and Materials: C57BL/6J mice received either lung alone or combined lung and whole-body irradiation (0-15 Gy). At 10 weeks after irradiation, animals were infected with 120 HAU influenza virus strain A/HKx31. Innate and adaptive immune cell recruitment was determined using flow cytometry. Cytokine and chemokine production and protein leakage into the lung after infection were assessed. Results: Prior irradiation led to a dose-dependent failure to regain body weight after infection and exacerbated mortality, but it did not affect virus-specific immune responses or virus clearance. Surviving irradiated animals displayed a persistent increase in total protein in bronchoalveolar lavage fluid and edema. Conclusions: Lung irradiation increased susceptibility to death after infection with influenza virus and impaired the ability to complete recovery. This altered response does not seem to be due to a radiation effect on the immune response, but it may possibly be an effect on epithelial repair.

Manning, Casey M. [Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York (United States)] [Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York (United States); Johnston, Carl J. [Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York (United States) [Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York (United States); Department of Pediatrics, University of Rochester Medical Center, Rochester, New York (United States); Reed, Christina K. [Department of Pediatrics, University of Rochester Medical Center, Rochester, New York (United States)] [Department of Pediatrics, University of Rochester Medical Center, Rochester, New York (United States); Lawrence, B. Paige [Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York (United States) [Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York (United States); Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York (United States); Williams, Jacqueline P. [Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York (United States)] [Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York (United States); Finkelstein, Jacob N., E-mail: Jacob_Finkelstein@urmc.rochester.edu [Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York (United States); Department of Pediatrics, University of Rochester Medical Center, Rochester, New York (United States); Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York (United States)

2013-05-01T23:59:59.000Z

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

E-Print Network 3.0 - active epstein-barr virus Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

79, No. 22 0022-538X0508.00 0 doi:10.1128JVI.79.22.1398413992.2005 Summary: , and S. Kenney. 2000. Epstein-Barr virus immediate-early proteins BZLF1 and BRLF1 activate the...

442

Novel Treatment with Neuroprotective and Antiviral Properties against a Neuroinvasive Human Respiratory Virus  

Science Journals Connector (OSTI)

...HCoV-OC43-infected mice. Moreover, memantine, an N-methyl-d-aspartate receptor...virus-infected mice. Interestingly, memantine attenuated mortality rates and body weight...dose-dependent manner. This novel action of memantine on viral replication strongly suggests...

Elodie Brison; Hlne Jacomy; Marc Desforges; Pierre J. Talbot

2013-11-13T23:59:59.000Z

443

Crystal Structure of the NS3 Protease-Helicase from Dengue Virus  

Science Journals Connector (OSTI)

...The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently. J. Biol...Peptide inhibitors of dengue virus NS3 protease. Part 1: Warhead. Bioorg. Med. Chem. Lett. 16: 36-39. 53 Yon, C...

Dahai Luo; Ting Xu; Cornelia Hunke; Gerhard Grber; Subhash G. Vasudevan; Julien Lescar

2007-10-17T23:59:59.000Z

444

Generation of defective virus after infection of newborn rats with reovirus.  

Science Journals Connector (OSTI)

...Research Article Generation of defective virus after infection of newborn...exceptions to this are described. Defective virions lacking the L1 segment...of cells J. VIROL. 4 .4 DEFECTIVE REOVIRUS IN VIVO 243 1? i...other experiments were being car- ried out with A mutants in...

D A Spandidos; A F Graham

1976-10-01T23:59:59.000Z

445

DNA Sensing-Independent Inhibition of Herpes Simplex Virus 1 Replication by DAI/ZBP1  

Science Journals Connector (OSTI)

...DNA Sensing-Independent Inhibition of Herpes Simplex Virus 1 Replication by DAI/ZBP1 Thanh H. Pham * Ki Mun Kwon Young-Eui Kim Kyeong Kyu Kim Jin-Hyun Ahn Address correspondence to Jin-Hyun Ahn, jahn@skku.edu . Department of Molecular Cell...

Thanh H. Pham; Ki Mun Kwon; Young-Eui Kim; Kyeong Kyu Kim; Jin-Hyun Ahn

2013-01-02T23:59:59.000Z

446

SAMHD1 Restricts Herpes Simplex Virus 1 in Macrophages by Limiting DNA Replication  

Science Journals Connector (OSTI)

...research-article Cellular Response to Infection SAMHD1 Restricts Herpes Simplex Virus 1 in Macrophages by Limiting DNA Replication Eui Tae Kim a Tommy E. White b Alberto Brandariz-Nunez b Felipe Diaz-Griffero b Matthew D. Weitzman a Address correspondence...

Eui Tae Kim; Tommy E. White; Alberto Brandariz-Nez; Felipe Diaz-Griffero; Matthew D. Weitzman

2013-09-25T23:59:59.000Z

447

STANDARDISING CLINICAL MEASUREMENTS OF BACTERIA AND VIRUSES USING NUCLEIC ACID TESTS  

Science Journals Connector (OSTI)

...CLINICAL MEASUREMENTS OF BACTERIA AND VIRUSES USING NUCLEIC ACID TESTS Jernej Pavsic a b Alison S. Devonshire c * Helen Parkes c Heinz...Institute of Virology, Berlin, Germany f . Nucleic acid based tests for infectious diseases currently used in the clinical laboratory...

Jernej Pavi?; Alison S. Devonshire; Helen Parkes; Heinz Schimmel; Carole A. Foy; Maria Karczmarczyk; Ion Gutirrez-Aguirre; Isobella Honeyborne; Jim F. Huggett; Timothy D. McHugh; Mojca Milavec; Heinz Zeichhardt; Jana el

2014-11-12T23:59:59.000Z

448

Phylogeography, Risk Factors and Genetic History of Hepatitis C Virus in Gabon, Central Africa  

E-Print Network (OSTI)

Phylogeography, Risk Factors and Genetic History of Hepatitis C Virus in Gabon, Central Africa Me´dicales de Franceville, Franceville, Gabon, 2 Centre Pasteur du Cameroun, Re´seau International, Gabon, 5 Institut Pasteur de Bangui, Re´seau International des Instituts Pasteur, Bangui, Central

Paris-Sud XI, Université de

449

Whole Blood as an Alternative to Plasma for Detection of Hepatitis C Virus RNA  

Science Journals Connector (OSTI)

...1110-1116. 10 Schmidt, W. N., P. Wu, J. Cederna, F. A. Mitros, D. R. LaBrecque, and J. T. Stapleton. 1997. Surreptitious hepatitis C virus (HCV) infection detected in the majority of patients with cryptogenic chronic hepatitis and negative...

Hubert Darius J. Daniel; Joel David; Paul R. Grant; Jeremy A. Garson; George M. Chandy; Priya Abraham

2008-08-13T23:59:59.000Z

450

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets  

Science Journals Connector (OSTI)

...virus particles. Segment 5 codes for the nucleocapsid protein...complexes (RNPs). Segment 7 codes for the viral matrix structural...NEP) previously known as NS2. NS1 is an antagonist of host innate...in accordance with the Dutch Code of Conduct for Biosecurity...

Sander Herfst; Eefje J. A. Schrauwen; Martin Linster; Salin Chutinimitkul; Emmie de Wit; Vincent J. Munster; Erin M. Sorrell; Theo M. Bestebroer; David F. Burke; Derek J. Smith; Guus F. Rimmelzwaan; Albert D. M. E. Osterhaus; Ron A. M. Fouchier

2012-06-22T23:59:59.000Z

451

A functional sequence-specific interaction between influenza A virus genomic RNA segments  

Science Journals Connector (OSTI)

...2/ nuclear export protein (NS2/NEP)] of the exemplar avian H5N2...of PB1, PB1-N40, NS1, or NS2/NEP (Fig. S3) and...mutant viruses. Viral RNA 7 codes for the matrix protein M1 and...vitro (26), whereas vRNA 6 codes for NA and interacts weakly with...

Cyrille Gavazzi; Matthieu Yver; Catherine Isel; Redmond P. Smyth; Manuel Rosa-Calatrava; Bruno Lina; Vincent Mouls; Roland Marquet

2013-01-01T23:59:59.000Z

452

Cell Surface Markers on Epithelial-Burkitt Hybrid Cells Superinfected with Epstein-Barr Virus  

Science Journals Connector (OSTI)

...Foundation. Ronald Glaser 2 Gilbert Lenoir Soldano Ferrone...de-The Department of Microbiology and Specialized Cancer...Epithelium immunology microbiology Erythrocytes immunology...Virus1 Ronald Glaser,2 Gilbert Lenoir, Soldano Ferrane...de-Th Department of Microbiology and Specialized Cancer...

Ronald Glaser; Gilbert Lenoir; Soldano Ferrone; Michele A. Pellegrino; and Guy de-Th

1977-07-01T23:59:59.000Z

453

Evaluation of Sindbis-M2e Virus Vector as a Universal Influenza A Vaccine  

E-Print Network (OSTI)

expressing the PR8 influenza strain's M2e peptide was developed as a potential universal DIVA vaccine. M2e is a conserved peptide amongst influenza A viruses; M2e-specific antibodies induce antibody-dependent cytotoxicity or phagocytosis of infected cells...

Vuong, Christine

2012-10-19T23:59:59.000Z

454

Occurrence of different types of infectious hematopoietic necrosis virus in fish.  

Science Journals Connector (OSTI)

...The appearance of type 2 IHNV at Minto Pond (MP...endemic strain on the North Santiam River was apparently...viruses. In addition, type 2 strains were isolated...supported by a grant from the Bonneville Power Administrations...Electrophoresis 1:32-37. 2. Amend, D. F. 1970...

Y L Hsu; H M Engelking; J C Leong

1986-12-01T23:59:59.000Z

455

Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes.  

Science Journals Connector (OSTI)

...animal hosts (e.g., Ross River virus, Western...540aa 807aa 549aa 610aa 1 2 3 4 Multiple intermediates...acetyl-pepstatin at 2.0-A resolution. J...conform to the adenovirus 2 endoproteinase cleavage...Gordon, H. Sanfacon, J. Bonneville, and T. Hohn. 1990...

W G Dougherty; B L Semler

1993-12-01T23:59:59.000Z

456

Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes.  

Science Journals Connector (OSTI)

...single-nucleotide changes from the cysteine...hosts (e.g., Ross River virus, Western...807aa 549aa 610aa 1 2 3 4 Multiple intermediates...acetyl-pepstatin at 2.0-A resolution...to the adenovirus 2 endoproteinase cleavage...H. Sanfacon, J. Bonneville, and T. Hohn. 1990...

W G Dougherty; B L Semler

1993-12-01T23:59:59.000Z

457

Inhibition of influenza virus infection with chitosansialyloligosaccharides ionic complex  

Science Journals Connector (OSTI)

Abstract With the recent emergence of drug-resistant influenza viruses, effective means of preventing and treating these contagious pathogens have become imperative. The binding receptors of influenza virus are sialyloligosaccharides (SOS), which are present on the surfaces of host cells, and are therefore attractive targets for antiviral development. We report the preparation and identification of a novel influenza virus entry inhibitor, designated chitosanSOS complex (CS complex). The CS complex was formed through noncovalent adsorption between cationic chitosan and anionic SOS, the latter derived from bovine colostrum. The preparation was accomplished in gram quantities from chitosan and bovine colostrum oligosaccharides by a one-step dialysis process. The inhibitory activity of the complex against influenza virus infection was determined by cytotoxicity inhibition assay (IC50=42?M). This simple preparation, combined with efficient anti-infective activity and the rich natural availability of chitosan and SOS, highlights the potential of the CS complex as a safe, practical agent for influenza prevention and control.

Shuihong Cheng; Huiqin Zhao; Yaozu Xu; Yawei Yang; Xun Lv; Peixing Wu; Xuebing Li

2014-01-01T23:59:59.000Z

458

Using Remote Sensing to Map the Principal Carrier of Monkeypox Virus in the Congo Basin  

E-Print Network (OSTI)

Using Remote Sensing to Map the Principal Carrier of Monkeypox Virus in the Congo Basin by Trevon consumed bushmeat species in rural areas of the Democratic Republic of Congo. Anne Rimoin, a CTR of Congo in Central Africa. Dr. Rimoin and her research teams are conducting clinical surveillance

Grether, Gregory

459

Inhibition of HIV-1 virus replication using small soluble Tat peptides Emmanuel Agbottah a  

E-Print Network (OSTI)

Inhibition of HIV-1 virus replication using small soluble Tat peptides Emmanuel Agbottah of viral resistance. During HIV infection, the viral activator Tat is needed for viral progeny formation in vivo. D 2005 Elsevier Inc. All rights reserved. Keywords: HIV; Cyclin-dependent kinase; Tat; Peptide

Zeng, Chen

460

Intracellular transactivation of HIV can account for the decelerating decay of virus load during drug therapy  

E-Print Network (OSTI)

. In HIV, the protein trans-activator of transcription (Tat) has been found to have a major role withinIntracellular transactivation of HIV can account for the decelerating decay of virus load during quantitative issues of HIV replication. However, several parts of the viral life cycle remain elusive. One

Utrecht, Universiteit

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Transcriptional Regulation of BK Virus by Nuclear Factor of Activated T Cells  

Science Journals Connector (OSTI)

...Regulation of BK Virus by Nuclear Factor of Activated...edu 1 Graduate Program in Pathobiology...we found that nuclear factor of activated...51). Previous research in our laboratory...infection. | Graduate Program in Pathobiology...Journal Article Research Support, N.I...

Joslynn A. Jordan; Kate Manley; Aisling S. Dugan; Bethany A. O'Hara; Walter J. Atwood

2009-12-02T23:59:59.000Z

462

Evaluation of Performance in Yearling Crossbred Steers following Bovine Viral Diarrhea Virus Challenge  

E-Print Network (OSTI)

Virus (BVDV) challenge. Yearling, F2 and F3 Nellore-Angus steers (n = 380) from the Texas A&M McGregor Genomics herd were utilized over 4 years, and were stratified by sire over three vaccine groups of modified-live (MLV), killed (KV), and non...

Runyan, Chase Anthony

2013-10-31T23:59:59.000Z

463

A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special?  

Science Journals Connector (OSTI)

...NW1 4RY, UK 6 US Geological Survey (retired), Fort Collins Science Center, Fort...The variables were rescaled to have unit variance before analysis in R using the...Johns Hopkins University Press. 31 Crawford, LV . 1966 A minute virus of mice. Virology...

2013-01-01T23:59:59.000Z

464

Mass production of volume phase holographic gratings for the VIRUS spectrograph array  

E-Print Network (OSTI)

The Visible Integral-field Replicable Unit Spectrograph (VIRUS) is a baseline array of 150 copies of a simple, fiber-fed integral field spectrograph that will be deployed on the Hobby-Eberly Telescope (HET). VIRUS is the first optical astronomical instrument to be replicated on an industrial scale, and represents a relatively inexpensive solution for carrying out large-area spectroscopic surveys, such as the HET Dark Energy Experiment (HETDEX). Each spectrograph contains a volume phase holographic (VPH) grating with a 138 mm diameter clear aperture as its dispersing element. The instrument utilizes the grating in first-order for 350-550 nm. Including witness samples, a suite of 170 VPH gratings has been mass produced for VIRUS. Here, we present the design of the VIRUS VPH gratings and a discussion of their mass production. We additionally present the design and functionality of a custom apparatus that has been used to rapidly test the first-order diffraction efficiency of the gratings for various discrete wav...

Chonis, Taylor S; Hill, Gary J; Clemens, J Christopher; Lee, Hanshin; Tuttle, Sarah E; Adams, Joshua J; Marshall, J L; DePoy, D L; Prochaska, Travis

2014-01-01T23:59:59.000Z

465

Infectious Bursal Disease Virus Capsid Assembly and Maturation by Structural Rearrangements of a Transient Molecular Switch  

Science Journals Connector (OSTI)

...VP2 trimers, namely, bent at the fivefold axis...pentamer is formed with bent contacts between VP2...2005. The birnavirus crystal structure reveals structural...three-dimensional reconstruction of spherical viruses by Fourier synthesis...M. Paetzel. 2006. Crystal structure of a novel...

Daniel Luque; Irene Saugar; Jos F. Rodrguez; Nuria Verdaguer; Dami Garriga; Carmen San Martn; Javier A. Velzquez-Muriel; Benes L. Trus; Jos L. Carrascosa; Jos R. Castn

2007-04-18T23:59:59.000Z

466

Structure and function of endogenous feline leukemia virus long terminal repeats and adjoining regions.  

Science Journals Connector (OSTI)

...long terminal repeat (LTR) of three independent loci (CFE-6, CFE-16, and CF-14) of endogenous feline leukemia virus...domestic cat genome was determined. The 3' LTR of the CFE-6 clone was also sequenced. The endogenous FeLV LTRs...

B T Berry; A K Ghosh; D V Kumar; D A Spodick; P Roy-Burman

1988-10-01T23:59:59.000Z

467

Genomics of Bacterial and Archaeal Viruses: Dynamics within the Prokaryotic Virosphere  

Science Journals Connector (OSTI)

...strains isolated from the Gulf of Mexico resulted in the production of...aspects of inovirus biology as well as their biotechnological appeal...Gram-negative bacteria as well as some Gram-positive species...Illegitimate recombination is well documented for these viruses...

Mart Krupovic; David Prangishvili; Roger W. Hendrix; Dennis H. Bamford

2011-12-01T23:59:59.000Z

468

Viral genetic determinants for thrips transmission of Tomato spotted wilt virus  

Science Journals Connector (OSTI)

...Bot. 54 , 402 405. 34 Bhat, A. I., Pappu, S. S., Pappu, H. R., Deom, C. R. & Culbreath, A. K. ( 1999 ) Virus...2795-2804. 2. Bhat, A. I., Pappu, S. S., Pappu, H. R., Deom, C. R. & Culbreath, A. K...

Sang-Hoon Sin; Brian C. McNulty; George G. Kennedy; James W. Moyer

2005-01-01T23:59:59.000Z

469

98% identical, 100% wrong: per cent nucleotide identity can lead plant virus epidemiology astray  

Science Journals Connector (OSTI)

...Press. Fauquet, C. M. , Briddon, R. W., Brown, J. K., Moriones...1094/PDIS-91-4-0466A ) Jones, R. A. 2009 Plant virus emergence and...1743-422X-2-21 ) Nischwitz, C. , Pappu, H. R., Mullis, S. W., Sparks, A...

2010-01-01T23:59:59.000Z

470

Bacterial carbon production in Lake Erie is influenced by viruses and solar radiation  

E-Print Network (OSTI)

Bacterial carbon production in Lake Erie is influenced by viruses and solar radiation Steven W basin, solar radiation was also dem- onstrated to regulate bacterial productivity. Ultraviolet radiation and >30% of the population of Canada. The lakes themselves constitute the largest system of fresh, surface

Wilhelm, Steven W.

471

Introduction Modified viruses are becoming the most commonly used vectors in gene therapy. The viral  

E-Print Network (OSTI)

. The chromatography protocol was developed at small- scale using RESOURCETM Q, a 1 ml column pre-packed with SOURCE 15 of a high transduction yield. Traditionally, purification of virus/viral vectors to high purities is done-step anion exchange chromatography purification on SOURCETM 15Q is a very attractive alternative to gradient

Lebendiker, Mario

472

Maize Dwarf Mosaic Virus: Effect of Strain A On Corn Inbreds, Single- and Double-Cross Hybrids.  

E-Print Network (OSTI)

. '. .,~. k ? -. MAIZE DWARF MOSAIC VIRUS: EFFECT OF STRAIN A ON CORN INBREDS, SINGLE- AND DOUBLE-CROSS HYBRIDS R. W. Toler, A.J. Bockholt and F. G. Alston* *Respectively, Professor, Department of Plant Sciences, Associate Professor, and Graduate... significantly affected the performance of the hybrid. MAIZE DWARF MOSAIC VIRUS: EFFECT OF STRAIN A ON CORN INBREDS, SINGLE- AND DOUBLE-CROSS HYBRIDS R. W. Toler, A.J. Bockho1t and F. G. Alston INTRODUCTION Maize dwarf mosaic virus strain A (MDMV...

Toler, R.W.; Bockholt, A.J.; Alston, F.G.

1982-01-01T23:59:59.000Z

473

Synthetic DNA Replication Bubbles Bound and Unwound with Twofold Symmetry by a Simian Virus 40 T-Antigen Double Hexamer  

Science Journals Connector (OSTI)

ARTICLE ANIMAL VIRUSES Synthetic DNA Replication Bubbles Bound and...examined the binding of TAgDH to synthetic DNA replication bubbles. Tests of...characterized the binding and unwinding of synthetic DNA replication bubbles by the TAgDH...

Natalia V. Smelkova; James A. Borowiec

1998-11-01T23:59:59.000Z

474

Inhibition of human immunodeficiency virus type-1 (HIV-1) glycoprotein-mediated cell-cell fusion by immunor (IM28)  

Science Journals Connector (OSTI)

Immunor (IM28), an analog of dehydroepiandrosterone (DHEA), inhibits human immunodeficiency virus type-1 (HIV-1) by inhibiting reverse ... ability of IM28 to inhibit the cell-cell fusion mediated by HIV envelope ...

Donatien Mavoungou; Virginie Poaty-Mavoungou; Marie-Yvonne Akoume

2005-02-01T23:59:59.000Z

475

Receptor Specificity and Transmission of H2N2 Subtype Viruses Isolated from the Pandemic of 1957  

E-Print Network (OSTI)

Influenza viruses of the H2N2 subtype have not circulated among humans in over 40 years. The occasional isolation of avian H2 strains from swine and avian species coupled with waning population immunity to H2 hemagglutinin ...

Pappas, Claudia

476

Emergency Medical Services Public Health Implications and Interim Guidance for the Ebola Virus in the United States  

E-Print Network (OSTI)

and Prevention. Available at: 6. Ebola Virus Disease. WorldOctober http://www.cdc.gov/vhf/ebola/pdf/checklist-patients-http://www.cdc.gov/vhf/ebola/index.html. Accessed disease in

McCoy, Christopher Eric; Lotfipour, Shahram; Chakravarthy, Bharath; Schultz, Carl; Barton, Erik

2014-01-01T23:59:59.000Z

477

Classification of Hepatitis C Virus Type 2 Isolates by Phylogenetic Analysis of Core and NS5 Regions  

Science Journals Connector (OSTI)

...Virus Type 2 Isolates by Phylogenetic Analysis of Core and NS5 Regions Mauro Pistello Fabrizio Maggi Claudia Fornai Alessandro Leonildi Antonietta Morrica Maria Linda Vatteroni Mauro Bendinelli Retrovirus Center and Virology Section Department of Biomedicine...

Mauro Pistello; Fabrizio Maggi; Claudia Fornai; Alessandro Leonildi; Antonietta Morrica; Maria Linda Vatteroni; Mauro Bendinelli

1999-06-01T23:59:59.000Z

478

Inter- and Intralaboratory Comparison of JC Polyomavirus Antibody Testing Using Two Different Virus-Like Particle-Based Assays  

Science Journals Connector (OSTI)

...PML), a debilitating, often fatal brain disease in immunocompromised patients...PML), a demyelinating disease of the brain, with typically fatal outcome (5, 6...virus-induced demyelinating disease of the human brain. Clin. Microbiol. Rev. 25 :471-506...

Piotr Kardas; Mohammadreza Sadeghi; Fabian H. Weissbach; Tingting Chen; Lea Hedman; Eeva Auvinen; Klaus Hedman; Hans H. Hirsch

2014-09-24T23:59:59.000Z

479

Using the Systematic Review Methodology To Evaluate Factors That Influence the Persistence of Influenza Virus in Environmental Matrices  

Science Journals Connector (OSTI)

...between measurement units even within the same...influenza virus in land disposal (25). The lack of...facilities or manure storage units. Data on the persistence...without host animals is critical to appropriate decision-making for issues...

C. K. Irwin; K. J. Yoon; C. Wang; S. J. Hoff; J. J. Zimmerman; T. Denagamage; A. M. O'Connor

2010-12-10T23:59:59.000Z

480

Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses  

Science Journals Connector (OSTI)

...SARS-CoV, maintains a purported nuclear localization signal, exhibits nuclear localization based on transfection...complex RNA and proteomics datasets across different virus infections...comparisons across systems virology datasets alleviated these problems and...

Vineet D. Menachery; Amie J. Eisfeld; Alexandra Schfer; Laurence Josset; Amy C. Sims; Sean Proll; Shufang Fan; Chengjun Li; Gabriele Neumann; Susan C. Tilton; Jean Chang; Lisa E. Gralinski; Casey Long; Richard Green; Christopher M. Williams; Jeffrey Weiss; Melissa M. Matzke; Bobbie-Jo Webb-Robertson; Athena A. Schepmoes; Anil K. Shukla; Thomas O. Metz; Richard D. Smith; Katrina M. Waters; Michael G. Katze; Yoshihiro Kawaoka; Ralph S. Baric

2014-06-01T23:59:59.000Z

Note: This page contains sample records for the topic "outsmarting flu viruses" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Interactions betweenPotato leafroll virus and potato plants and their implications for assessment of infection resistance  

Science Journals Connector (OSTI)

Se investigaron los efectos y mtodos de inoculacin, de aislamientos del virus del enrollamiento de la papa (PLRV), sobre la resistencia de clones y cultivares de papa. En ... fue rutinariamente utilizado en el ...

Bogdan Flis; Jerzy Syller; Iwona Wasilewicz-Flis

482

Effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on synthesis of herpes simplex virus type 1-specific polypeptides.  

Science Journals Connector (OSTI)

...research-article Research Article Effect of (E)-5-(2-bromovinyl...modification of polypeptides. Effect of (E)-5-(2-bromovinyl...simplex virus DNA: relation- ship between antiviral activity and effects on DNA structure. Biochim...

S A Siegel; M J Otto; E De Clercq; W H Prusoff

1984-05-01T23:59:59.000Z

483

Telomerase Regulation and Telomere Maintenance during Human T-cell Leukemia/Lymphoma Virus (HTLV-I) Transformation  

E-Print Network (OSTI)

Human T-cell leukemia/lymphoma virus (HTLV-I) is the etiological agent of the lymphoproliferative disorder, adult T-cell leukemia/lymphoma (ATLL) and the neurodegenerative disease, tropical spastic paraparesis/HTLV-I-associated ...

Bellon, Marcia Lynn

2008-04-29T23:59:59.000Z

484

Characterization and Mapping of the Gene Conferring Resistance to Rift Valley Fever Virus Hepatic Disease in WF.LEW Rats  

E-Print Network (OSTI)

Rift Valley Fever Virus is a plebovirus that causes epidemics and epizootics in sub-Saharan African countries but has expanded to Egypt and the Arabian Peninsula. The laboratory rat (Rattus norvegicus) is susceptible to RVFV and has been shown...

Callicott, Ralph J.

2010-01-14T23:59:59.000Z

485

Live Attenuated Tetravalent Dengue Virus Host Range Vaccine Is Immunogenic in African Green Monkeys following a Single Vaccination  

Science Journals Connector (OSTI)

...The structure of Sindbis virus produced from vertebrate and invertebrate hosts as determined by small-angle neutron scattering. J. Virol. 84 :5270-5276. doi: 10.1128/JVI.00044-10 . 41. Kostyuchenko, VA , PL Chew, TS Ng...

Caitlin M. Briggs; Katherine M. Smith; Amanda Piper; Emerson Huitt; Carla J. Spears; Michelle Quiles; Mariana Ribeiro; Malcolm E. Thomas; Dennis T. Brown; Raquel Hernandez

2014-04-02T23:59:59.000Z

486

Heterogeneous Nuclear Ribonucleoprotein K Supports Vesicular Stomatitis Virus Replication by Regulating Cell Survival and Cellular Gene Expression  

Science Journals Connector (OSTI)

...and prompt us to undertake additional research to uncover its involvement in virus-host...arginine dimethylation of heterogeneous nuclear ribonucleoprotein K by protein-arginine...erythroid cell maturation: heterogeneous nuclear ribonucleoprotein K controls the expression...

Phat X. Dinh; Anshuman Das; Rodrigo Franco; Asit K. Pattnaik

2013-07-10T23:59:59.000Z

487

Impaired Replication of Hepatitis C Virus Containing Mutations in a Conserved NS5B Retinoblastoma Protein-Binding Motif  

Science Journals Connector (OSTI)

...D. C. Young, J. Bard, R. Chopra, G. Krishnamurthy, T. Mansour, and J. OConnell. 2008. Molecular mechanism of heaptitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, Hcv-796. Antimicrob. Agents Chemother...

David R. McGivern; Rodrigo A. Villanueva; Sreedhar Chinnaswamy; C. Cheng Kao; Stanley M. Lemon

2009-05-20T23:59:59.000Z

488

The virulencetransmission trade-off in vector-borne plant viruses: a review of (non-)existing studies  

Science Journals Connector (OSTI)

...in the field. Transmission of vector-borne...through different routes depending on virus genera. Modes of transmission are briefly summarized...cultivars and breeding lines. Plant Dis...acquisition and transmission by its whitefly...

2010-01-01T23:59:59.000Z

489

Genomics Approaches to Study Molecular and Cellular Mechanisms of Host Response to Avian Influenza Virus in Chickens  

E-Print Network (OSTI)

are always accompanied by remarkable changes in gene expression. Therefore understanding the gene expression profile of infected cells at the global level is important to get insights into interactions between hosts and viruses. Different genomic approaches...

Wang, Ying

2012-02-14T23:59:59.000Z

490

Some physical and biological properties of the nuclear polyhedrosis virus of Heliothis zea (Boddie) and Heliothis virescens (Fabricius)  

E-Print Network (OSTI)

University Directed by: Dr. L. L. Keeley Laboratory investi ations were conducted into so ie of the physical and biological properties of the nuclear polyhedrosis virus ("!PV) of Heliothis zea (Boddie) and Peiiothi s virescens (Fabricius). information... the ranges of shapes and. sizes reported f' or other insect nuclear viruses. In contrast, the strength of alkali and dis- solving period necessary to dissolve Heliothis nuclear polyhedra are somewhat higher than those reported for other insect polyhedra...

MacFarlane, Johnny James

2012-06-07T23:59:59.000Z

491

A screen for genetic suppressor elements of hepatitis C virus identifies a supercharged protein inhibitor of viral replication  

E-Print Network (OSTI)

A Screen for Genetic Suppressor Elements of Hepatitis C Virus Identifies a Supercharged Protein Inhibitor of Viral Replication Rudo L. Simeon1, Zhilei Chen1,2* 1 Artie McFerrin Department of Chemical Engineering, Texas A&M University, College.... ACS Chemical Biology. 30. Lindenbach BD, Evans MJ, Syder AJ, Wolk B, Tellinghuisen TL, et al. (2005) Complete Replication of Hepatitis C Virus in Cell Culture. Science 309: 623 626. 31. Cowan S, Hatziioannou T, Cunningham T, Muesing MA, Gottlinger HG...

Simeon, Rudo L.; Chen, Zhilei

2013-12-31T23:59:59.000Z

492

5 SEPTEMBER 2014 VOL 345 ISSUE 6201 1097SCIENCE sciencemag.org 5 SEPTEMBER 2014 VOLUME 345 ISSUE 6201  

E-Print Network (OSTI)

By A. Gibbons 1108 ESTIMATING THE EBOLA EPIDEMIC Modelers of infectious diseases strive to predict of the week's news IN DEPTH 1105 POLICE CLAIM LEADING FLU RESEARCHER ILLEGALLY SOLD VIRUS Italian probe depicts web of scandal, including illegal animal vaccines and deliberate outbreaks By L. Margottini 1106

Napp, Nils

493

From the Director We live in a world of constant change, with perhaps the greatest changes occurring unnoticed to the human eye, within the burgeon-  

E-Print Network (OSTI)

be harnessed to help us predict and control disease outbreaks. But today, our future is uncertain. Human of stories on diseases with exotic names such as bird flu, E. coli O157:H7, West Nile virus and, closer to understand, predict and control infectious threats. This requires collaboration across disciplines and scales

Kane, Andrew S.

494

Avian influenza H5N1 in viverrids: implications for wildlife health and conservation  

Science Journals Connector (OSTI)

...associated with poultry outbreaks and transmission...poultry, one might predict that those species...Thailand and Vietnam outbreak in 2004-2005...Y Guan2005Avian flu: H5N1 virus outbreak in migratory waterfowl...Katz1999A mouse model for the evaluation...

2006-01-01T23:59:59.000Z

495

VIPR HMM: A hidden Markov model for detecting recombination with microbial detection microarrays  

E-Print Network (OSTI)

to disease outbreaks. H1N1, the influenza virus responsible for the 2009 outbreak of pandemic flu, is thought1 VIPR HMM: A hidden Markov model for detecting recombination with microbial detection microarrays. Results: We have expanded upon our previous implementation of VIPR by incorporating a hidden Markov model

Wang, David

496

The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway  

SciTech Connect

Ebola virus (EBOV) has been reported to enter cultured cell lines via a dynamin-2-independent macropinocytic pathway or clathrin-mediated endocytosis. The route(s) of productive EBOV internalization into physiologically relevant cell types remain unexplored, and viral-host requirements for this process are incompletely understood. Here, we use electron microscopy and complementary chemical and genetic approaches to demonstrate that the viral glycoprotein, GP, induces macropinocytic uptake of viral particles into cells. GP's highly-glycosylated mucin domain is dispensable for virus-induced macropinocytosis, arguing that interactions between other sequences in GP and the host cell surface are responsible. Unexpectedly, we also found a requirement for the large GTPase dynamin-2, which is proposed to be dispensable for several types of macropinocytosis. Our results provide evidence that EBOV uses an atypical dynamin-dependent macropinocytosis-like entry pathway to enter Vero cells, adherent human peripheral blood-derived monocytes, and a mouse dendritic cell line.

Mulherkar, Nirupama [Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461 (United States); Raaben, Matthijs [Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115 (United States); Torre, Juan Carlos de la [Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037 (United States); Whelan, Sean P. [Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115 (United States); Chandran, Kartik, E-mail: kartik.chandran@einstein.yu.edu [Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461 (United States)

2011-10-25T23:59:59.000Z

497

Single-particle cryo-electron microscopy of Rift Valley fever virus  

SciTech Connect

Rift Valley fever virus (RVFV; Bunyaviridae; Phlebovirus) is an emerging human and veterinary pathogen causing acute hepatitis in ruminants and has the potential to cause hemorrhagic fever in humans. We report a three-dimensional reconstruction of RVFV vaccine strain MP-12 (RVFV MP-12) by cryo-electron microcopy using icosahedral symmetry of individual virions. Although the genomic core of RVFV MP-12 is apparently poorly ordered, the glycoproteins on the virus surface are highly symmetric and arranged on a T = 12 icosahedral lattice. Our RVFV MP-12 structure allowed clear identification of inter-capsomer contacts and definition of possible glycoprotein arrangements within capsomers. This structure provides a detailed model for phleboviruses, opens new avenues for high-resolution structural studies of the bunyavirus family, and aids the design of antiviral diagnostics and effective subunit vaccines.

Sherman, Michael B. [Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 (United States); Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555 (United States); Freiberg, Alexander N. [Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 (United States); Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555 (United States); Holbrook, Michael R. [Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 (United States); Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555 (United States); Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555 (United States); Watowich, Stanley J., E-mail: watowich@xray.utmb.ed [Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 (United States); Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555 (United States); Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555 (United States); Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555 (United States)

2009-04-25T23:59:59.000Z

498

Evidence of Airborne Transmission of the Severe Acute Respiratory Syndrome Virus  

Science Journals Connector (OSTI)

...rates through doorways and windows (closed and open) were assumed to be dependent on differences in air pressure. Differences in air temperature and winds, as well as the exhaust from fans, could introduce driving pressures. We used the software program MIX, which was developed by Li et al. to model the... This analysis used detailed airflow-dynamics studies to model the possible airborne spread of the virus in the large outbreak of the severe acute respiratory syndrome (SARS) in the Amoy Gardens housing complex in Hong Kong. The spatial distribution of the cases supports the hypothesis that a single index patient was the source of infection and the infection was spread by virus-laden aerosols.

Yu I.T.S.; Li Y.; Wong T.W.

2004-04-22T23:59:59.000Z

499

The E6 protein from vaccinia virus is required for the formation of immature virions  

SciTech Connect

An IPTG-inducible mutant in the E6R gene of vaccinia virus was used to study the role of the E6 virion core protein in viral replication. In the absence of the inducer, the mutant exhibited a normal pattern DNA replication, concatemer resolution and late gene expression, but it showed an inhibition of virion structural protein processing it failed to produce infectious particles. Electron microscopic analysis showed that in the absence of IPTG viral morphogenesis was arrested before IV formation: crescents, aberrant or empty IV-like structures, and large aggregated virosomes were observed throughout the cytoplasm. The addition of IPTG to release a 12-h block showed that virus infectious particles could be formed in the absence of de novo DNA synthesis. Our observations show that in the absence of E6 the association of viroplasm with viral membrane crescents is impaired.

Boyd, Olga; Turner, Peter C.; Moyer, Richard W.; Condit, Richard C. [Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610 (United States); Moussatche, Nissin, E-mail: nissin@ufl.ed [Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610 (United States)

2010-04-10T23:59:59.000Z

500

Protective immunity to H7N9 influenza viruses elicited by synthetic DNA vaccine  

Science Journals Connector (OSTI)

Abstract Despite an intensive vaccine program influenza infections remain a major health problem, due to the viruses ability to change its envelope glycoprotein hemagglutinin (HA), through shift and drift, permitting influenza to escape protection induced by current vaccines or natural immunity. Recently a new variant, H7N9, has emerged in China causing global concern. First, there have been more than 130 laboratory-confirmed human infections resulting in an alarmingly high death rate (32.3%). Second, genetic changes found in H7N9 appear to be associated with enabling avian influenza viruses to spread more effectively in mammals, thus transmitting infections on a larger scale. Currently, no vaccines or drugs are effectively able to target H7N9. Here, we report the rapid development of a synthetic consensus DNA vaccine (pH7HA) to elicit potent protective immunity against the H7N9 viruses. We show that pH7HA induces broad antibody responses that bind to divergent \\{HAs\\} from multiple new members of the H7N9 family. These antibody responses result in high-titer HAI against H7N9. Simultaneously, this vaccine induces potent polyfunctional effector CD4 and CD8T cell memory responses. Animals vaccinated with pH7HA are completely protected from H7N9 virus infection and any morbidity associated with lethal challenge. This study establishes that this synthetic consensus DNA vaccine represents a new tool for targeting emerging infection, and more importantly, its design, testing and development into seed stock for vaccine production in a few days in the pandemic setting has significant implications for the rapid deployment of vaccines protecting against emerging infectious diseases.

Jian Yan; Daniel O. Villarreal; Trina Racine; Jaemi S. Chu; Jewell N. Walters; Matthew P. Morrow; Amir S. Khan; Niranjan Y. Sardesai; J. Joseph Kim; Gary P. Kobinger; David B. Weiner

2014-01-01T23:59:59.000Z