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Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Cleavage of nucleic acids  

DOE Patents [OSTI]

The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.

Prudent, James R. (Madison, WI); Hall, Jeff G. (Waunakee, WI); Lyamichev, Victor I. (Madison, WI); Brow; Mary Ann D. (Madison, WI); Dahlberg, James E. (Madison, WI)

2010-11-09T23:59:59.000Z

2

Cleavage of nucleic acids  

DOE Patents [OSTI]

The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.

Prudent, James R. (Madison, WI); Hall, Jeff G. (Madison, WI); Lyamichev, Victor L. (Madison, WI); Brow, Mary Ann D. (Madison, WI); Dahlberg, James E. (Madison, WI)

2007-12-11T23:59:59.000Z

3

Nucleic acid detection compositions  

DOE Patents [OSTI]

The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.

Prudent, James R. (Madison, WI); Hall, Jeff G. (Madison, WI); Lyamichev, Victor I. (Madison, WI); Brow, Mary Ann (Madison, WI); Dahlberg, James L. (Madison, WI)

2008-08-05T23:59:59.000Z

4

Nucleic Acids Research, 2009, 114 doi:10.1093/nar/gkn1064  

E-Print Network [OSTI]

Nucleic Acids Research, 2009, 1­14 doi:10.1093/nar/gkn1064 Allegro: Analyzing expression- ulate. We present Allegro, a method for de-novo dis- covery of cis-regulatory transcriptional programs by a group of co-regulated genes. We show that Allegro is more accurate and sensitive than existing

Shamir, Ron

5

Nucleic Acids Research, Vol. 20, No. 3 613 An alfalfa cDNA encodes a protein with similarity to  

E-Print Network [OSTI]

Nucleic Acids Research, Vol. 20, No. 3 613 An alfalfa cDNA encodes a protein with similarity to an understanding of the function of these proteins in RNA processing. We have isolated an alfalfa cDNA whose, the putative alfalfa protein is clearly related to the human snRNP-E protein. However, since the protein

Hirt, Heribert

6

1996 Oxford University Press 47094718Nucleic Acids Research, 1996, Vol. 24, No. 23 Logitlinear models for the prediction of splice sites in  

E-Print Network [OSTI]

© 1996 Oxford University Press 4709­4718Nucleic Acids Research, 1996, Vol. 24, No. 23 Logitlinear the degree of fit to some average signal pattern around known splice sites in a learning set (e.g., 3

Brendel, Volker

7

Self-assembling multimeric nucleic acid constructs  

DOE Patents [OSTI]

The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify diseased tissue or cells. Repeated administrations of multimeric nucleic acid compositions produce a rapid and specific amplification of nucleic acid constructs and their attached functional groups. For treatment purposes, functional groups may be toxins, radioisotopes, genes or enzymes. Diagnostically, labeled multimeric constructs may be used to identify specific targets in vivo or in vitro. Multimeric nucleic acids may also be used in nanotechnology and to create self-assembling polymeric aggregates such as membranes of defined porosity, microcircuits and many other products. 5 figs.

Cantor, C.R.; Niemeyer, C.M.; Smith, C.L.; Sano, Takeshi; Hnatowich, D.J.; Rusckowski, M.

1996-10-01T23:59:59.000Z

8

Self-assembling multimeric nucleic acid constructs  

DOE Patents [OSTI]

The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify diseased tissue or cells. Repeated administrations of multimeric nucleic acid compositions produce a rapid and specific amplification of nucleic acid constructs and their attached functional groups. For treatment purposes, functional groups may be toxins, radioisotopes, genes or enzymes. Diagnostically, labeled multimeric constructs may be used to identify specific targets in vivo or in vitro. Multimeric nucleic acids may also be used in nanotechnology and to create self-assembling polymeric aggregates such as membranes of defined porosity, microcircuits and many other products.

Cantor, Charles R. (Boston, MA); Niemeyer, Christof M. (Bremen, DE); Smith, Cassandra L. (Boston, MA); Sano, Takeshi (Boston, MA); Hnatowich, Donald J. (Brookline, MA); Rusckowski, Mary (Southborough, MA)

1999-10-12T23:59:59.000Z

9

Self-assembling multimeric nucleic acid constructs  

DOE Patents [OSTI]

The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify diseased tissue or cells. Repeated administrations of multimeric nucleic acid compositions produce a rapid and specific amplification of nucleic acid constructs and their attached functional groups. For treatment purposes, functional groups may be toxins, radioisotopes, genes or enzymes. Diagnostically, labeled multimeric constructs may be used to identify specific targets in vivo or in vitro. Multimeric nucleic acids may also be used in nanotechnology and to create self-assembling polymeric aggregates such as membranes of defined porosity, microcircuits and many other products.

Cantor, Charles R. (Boston, MA); Niemeyer, Christof M. (Bremen, DE); Smith, Cassandra L. (Boston, MA); Sano, Takeshi (Boston, MA); Hnatowich, Donald J. (Brookline, MA); Rusckowski, Mary (Southborough, MA)

1996-01-01T23:59:59.000Z

10

Double stranded nucleic acid biochips  

DOE Patents [OSTI]

This invention describes a new method of constructing double-stranded DNA (dsDNA) microarrays based on the use of pre-synthesized or natural DNA duplexes without a stem-loop structure. The complementary oligonucleotide chains are bonded together by a novel connector that includes a linker for immobilization on a matrix. A non-enzymatic method for synthesizing double-stranded nucleic acids with this novel connector enables the construction of inexpensive and robust dsDNA/dsRNA microarrays. DNA-DNA and DNA-protein interactions are investigated using the microarrays.

Chernov, Boris; Golova, Julia

2006-05-23T23:59:59.000Z

11

Methods for analyzing nucleic acid sequences  

SciTech Connect (OSTI)

The present invention is directed to a method of sequencing a target nucleic acid. The method provides a complex comprising a polymerase enzyme, a target nucleic acid molecule, and a primer, wherein the complex is immobilized on a support Fluorescent label is attached to a terminal phosphate group of the nucleotide or nucleotide analog. The growing nucleic acid strand is extended by using the polymerase to add a nucleotide analog to the nucleic acid strand. The nucleotide analog added to the oligonucleotide primer as a result of the polymerizing step is identified. The time duration of the signal from labeled nucleotides or nucleotide analogs that become incorporated is distinguished from freely diffusing labels by a longer retention in the observation volume for the nucleotides or nucleotide analogs that become incorporated than for the freely diffusing labels.

Korlach, Jonas (Ithaca, NY); Webb, Watt W. (Ithaca, NY); Levene, Michael (Ithaca, NY); Turner, Stephen (Ithaca, NY); Craighead, Harold G. (Ithaca, NY); Foquet, Mathieu (Ithaca, NY)

2011-05-17T23:59:59.000Z

12

Amplification of trace amounts of nucleic acids  

DOE Patents [OSTI]

Methods of reducing background during amplification of small amounts of nucleic acids employ careful analysis of sources of low level contamination. Ultraviolet light can be used to reduce nucleic acid contaminants in reagents and equipment. "Primer-dimer" background can be reduced by judicious design of primers. We have shown clean signal-to-noise with as little as starting material as one single human cell (.about.6 picogram), E. coli cell (.about.5 femtogram) or Prochlorococcus cell (.about.3 femtogram).

Church, George M. (Brookline, MA); Zhang, Kun (Brighton, MA)

2008-06-17T23:59:59.000Z

13

Nucleic acid based fluorescent sensor for copper detection  

DOE Patents [OSTI]

A nucleic acid enzyme responsive to copper, comprising an oligonucleotide comprising a nucleotide sequence of SEQ ID NO:1, wherein the nucleic acid enzyme is not self-cleaving.

Lu, Yi; Liu, Juewen

2013-04-02T23:59:59.000Z

14

Method for nucleic acid isolation using supercritical fluids  

DOE Patents [OSTI]

A method for detecting the presence of a microorganism in an environmental sample involves contacting the sample with a supercritical fluid to isolate nucleic acid from the microorganism, then detecting the presence of a particular sequence within the isolated nucleic acid. The nucleic acid may optionally be subjected to further purification.

Nivens, David E. (11912 Kingsgate Rd., Knoxville, TN 37911); Applegate, Bruce M. (3700 Sutherland Ave. #Q2, Knoxville, TN 37911)

1999-01-01T23:59:59.000Z

15

Nucleic acid analysis using terminal-phosphate-labeled nucleotides  

DOE Patents [OSTI]

The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the activity of a nucleic acid polymerizing enzyme on the template nucleic acid molecule to be sequenced is followed in real time. The sequence is deduced by identifying which base is being incorporated into the growing complementary strand of the target nucleic acid by the catalytic activity of the nucleic acid polymerizing enzyme at each step in the sequence of base additions. A polymerase on the target nucleic acid molecule complex is provided in a position suitable to move along the target nucleic acid molecule and extend the oligonucleotide primer at an active site. A plurality of labelled types of nucleotide analogs are provided proximate to the active site, with each distinguishable type of nucleotide analog being complementary to a different nucleotide in the target nucleic acid sequence. The growing nucleic acid strand is extended by using the polymerase to add a nucleotide analog to the nucleic acid strand at the active site, where the nucleotide analog being added is complementary to the nucleotide of the target nucleic acid at the active site. The nucleotide analog added to the oligonucleotide primer as a result of the polymerizing step is identified. The steps of providing labelled nucleotide analogs, polymerizing the growing nucleic acid strand, and identifying the added nucleotide analog are repeated so that the nucleic acid strand is further extended and the sequence of the target nucleic acid is determined.

Korlach, Jonas (Ithaca, NY); Webb, Watt W. (Ithaca, NY); Levene, Michael (Ithaca, NY); Turner, Stephen (Ithaca, NY); Craighead, Harold G. (Ithaca, NY); Foquet, Mathieu (Ithaca, NY)

2008-04-22T23:59:59.000Z

16

Detection of nucleic acids by multiple sequential invasive cleavages  

DOE Patents [OSTI]

The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof. The present invention further relates to methods and devices for the separation of nucleic acid molecules based on charge. The present invention also provides methods for the detection of non-target cleavage products via the formation of a complete and activated protein binding region. The invention further provides sensitive and specific methods for the detection of human cytomegalovirus nucleic acid in a sample.

Hall, Jeff G; Lyamichev, Victor I; Mast, Andrea L; Brow, Mary Ann D

2012-10-16T23:59:59.000Z

17

Method for analyzing nucleic acids by means of a substrate having a microchannel structure containing immobilized nucleic acid probes  

DOE Patents [OSTI]

A method and apparatus for analyzing nucleic acids includes immobilizing nucleic probes at specific sites within a microchannel structure and moving target nucleic acids into proximity to the probes in order to allow hybridization and fluorescence detection of specific target sequences.

Ramsey, J. Michael (Knoxville, TN); Foote, Robert S. (Oak Ridge, TN)

2002-01-01T23:59:59.000Z

18

Nucleic acids, compositions and uses thereof  

DOE Patents [OSTI]

The subject invention provides at least one nucleic acid sequence encoding an aldouronate-utilization regulon isolated from Paenibacillus sp. strain JDR-2, a bacterium which efficiently utilizes xylan and metabolizes aldouronates (methylglucuronoxylosaccharides). The subject invention also provides a means for providing a coordinately regulated process in which xylan depolymerization and product assimilation are coupled in Paenibacillus sp. strain JDR-2 to provide a favorable system for the conversion of lignocellulosic biomass to biobased products. Additionally, the nucleic acid sequences encoding the aldouronate-utilization regulon can be used to transform other bacteria to form organisms capable of producing a desired product (e.g., ethanol, 1-butanol, acetoin, 2,3-butanediol, 1,3-propanediol, succinate, lactate, acetate, malate or alanine) from lignocellulosic biomass.

Preston, III, James F. (Micanopy, FL); Chow, Virginia (Gainesville, FL); Nong, Guang (Gainesville, FL); Rice, John D. (Gainesville, FL); St. John, Franz J. (Baltimore, MD)

2012-02-21T23:59:59.000Z

19

Nucleic acid compositions and the encoding proteins  

SciTech Connect (OSTI)

The subject invention provides at least one nucleic acid sequence encoding an aldouronate-utilization regulon isolated from Paenibacillus sp. strain JDR-2, a bacterium which efficiently utilizes xylan and metabolizes aldouronates (methylglucuronoxylosaccharides). The subject invention also provides a means for providing a coordinately regulated process in which xylan depolymerization and product assimilation are coupled in Paenibacillus sp. strain JDR-2 to provide a favorable system for the conversion of lignocellulosic biomass to biobased products. Additionally, the nucleic acid sequences encoding the aldouronate-utilization regulon can be used to transform other bacteria to form organisms capable of producing a desired product (e.g., ethanol, 1-butanol, acetoin, 2,3-butanediol, 1,3-propanediol, succinate, lactate, acetate, malate or alanine) from lignocellulosic biomass.

Preston, III, James F.; Chow, Virginia; Nong, Guang; Rice, John D.; St. John, Franz J.

2014-09-02T23:59:59.000Z

20

Nucleic Acid Database: a Repository of Three-Dimensional Information about Nucleic Acids  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

The Nucleic Acid Database (NDB) provides 3-D structural information about nucleic acids.  It is a relational database designed to facilitate the easy search for nucleic acid structures using any of the stored primary or derived structural features. Reports can then be created describing any properties of the selected structures and structures may be viewed in several different formats, including the mmCIF format, the NDB Atlas format, the NDB coordinate format, or the PDB coordinate format. Browsing structure images created directly from coordinates in the repository can also be done. More than 7000 structures have been released as of May 2014. This website also includes a number of specialized tools and interfaces. The NDB Project is funded by the National Institutes of Health and has been funded by the National Science Foundation and the Department of Energy in the past.

Berman, H.M.; Olson, W.K.; Beveridge, D.L.; Westbrook, J.; Gelbin, A.; Demeny, T.; Hsieh, S.H.; Srinivasan, A.R.; Schneider, B.

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

EGVII endoglucanase and nucleic acids encoding the same  

DOE Patents [OSTI]

The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVII, recombinant EGVII proteins and methods for producing the same.

Dunn-Coleman, Nigel; Goedegebuur, Frits; Ward, Michael; Yao, Jian

2014-02-25T23:59:59.000Z

22

EGVII endoglucanase and nucleic acids encoding the same  

DOE Patents [OSTI]

The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVII, recombinant EGVII proteins and methods for producing the same.

Dunn-Coleman, Nigel (Los Gatos, CA); Goedegebuur, Frits (Vlaardingen, NL); Ward, Michael (San Francisco, CA); Yao, Jian (Sunnyvale, CA)

2008-11-11T23:59:59.000Z

23

Nucleic acid amplification using modular branched primers  

DOE Patents [OSTI]

Methods and compositions expand the options for making primers for use in amplifying nucleic acid segments. The invention eliminates the step of custom synthesis of primers for Polymerase Chain Reactions (PCR). Instead of being custom-synthesized, a primer is replaced by a combination of several oligonucleotide modules selected from a pre-synthesized library. A modular combination of just a few oligonucleotides essentially mimics the performance of a conventional, custom-made primer by matching the sequence of the priming site in the template. Each oligonucleotide module has a segment that matches one of the stretches within the priming site.

Ulanovsky, Levy (Westmont, IL)

2001-01-01T23:59:59.000Z

24

Nucleic acid based fluorescent sensor for mercury detection  

DOE Patents [OSTI]

A nucleic acid enzyme comprises an oligonucleotide containing thymine bases. The nucleic acid enzyme is dependent on both Hg.sup.2+and a second ion as cofactors, to produce a product from a substrate. The substrate comprises a ribonucleotide, a deoxyribonucleotide, or both.

Lu, Yi; Liu, Juewen

2013-02-05T23:59:59.000Z

25

E-Print Network 3.0 - archetypical nucleic acid Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

archetypical nucleic acid Search Powered by Explorit Topic List Advanced Search Sample search results for: archetypical nucleic acid Page: << < 1 2 3 4 5 > >> 1 Multiple Sequence...

26

E-Print Network 3.0 - a-form nucleic acid Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: a-form nucleic acid Page: << < 1 2 3 4 5 > >> 1 The Right Chemistry: an Updated Nucleic Acids Textbook Summary: The Right Chemistry: an Updated Nucleic...

27

Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids  

DOE Patents [OSTI]

A composition for inactivating a target nucleic acid which comprises an oligonucleoside alkyl or arylphosphonate analogue which is complementary to the sequence of the target nucleic acid is provided. It includes a functional group which reacts with the target nucleic acid to render the target nucleic acid inactive or nonfunctional. 16 figs.

Miller, P.S.; Ts'o, P.O.P.

1999-06-15T23:59:59.000Z

28

Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids  

DOE Patents [OSTI]

A composition for inactivating a target nucleic acid which comprises an oligonucleoside alkyl or arylphosphonate analogue which is complementary to the sequence of the target nucleic acid and includes a functional group which reacts with the target nucleic acid to render the target nucleic acid inactive or nonfunctional.

Miller, Paul S. (Baltimore, MD); Ts'o, Paul O.P. (Lutherville, MD)

1999-06-15T23:59:59.000Z

29

Isolated menthone reductase and nucleic acid molecules encoding same  

DOE Patents [OSTI]

The present invention provides isolated menthone reductase proteins, isolated nucleic acid molecules encoding menthone reductase proteins, methods for expressing and isolating menthone reductase proteins, and transgenic plants expressing elevated levels of menthone reductase protein.

Croteau, Rodney B; Davis, Edward M; Ringer, Kerry L

2013-04-23T23:59:59.000Z

30

Thermoplastic Microfluidic Device for On-Chip Purification of Nucleic Acids for Disposable  

E-Print Network [OSTI]

Thermoplastic Microfluidic Device for On-Chip Purification of Nucleic Acids for Disposable, Brookline, Massachusetts 02446 A polymeric microfluidic device for solid-phase extraction (SPE applications. Microfluidic approaches to nucleic acid isolation have therefore received great attention

31

Polymerase chain reaction system using magnetic beads for analyzing a sample that includes nucleic acid  

DOE Patents [OSTI]

A polymerase chain reaction system for analyzing a sample containing nucleic acid includes providing magnetic beads; providing a flow channel having a polymerase chain reaction chamber, a pre polymerase chain reaction magnet position adjacent the polymerase chain reaction chamber, and a post pre polymerase magnet position adjacent the polymerase chain reaction chamber. The nucleic acid is bound to the magnetic beads. The magnetic beads with the nucleic acid flow to the pre polymerase chain reaction magnet position in the flow channel. The magnetic beads and the nucleic acid are washed with ethanol. The nucleic acid in the polymerase chain reaction chamber is amplified. The magnetic beads and the nucleic acid are separated into a waste stream containing the magnetic beads and a post polymerase chain reaction mix containing the nucleic acid. The reaction mix containing the nucleic acid flows to an analysis unit in the channel for analysis.

Nasarabadi, Shanavaz (Livermore, CA)

2011-01-11T23:59:59.000Z

32

E-Print Network 3.0 - ampliprep nucleic acid Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Affinity for Nucleic Acids Summary: for Nucleic Acids Coby B. Carlson and Peter A. Beal* Department of Chemistry, UniVersity of Utah, 315 South... if immobilization of a PAC...

33

E-Print Network 3.0 - azobenzene-modified nucleic acid Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Affinity for Nucleic Acids Summary: for Nucleic Acids Coby B. Carlson and Peter A. Beal* Department of Chemistry, UniVersity of Utah, 315 South... if immobilization of a PAC...

34

Methods of staining target chromosomal DNA employing high complexity nucleic acid probes  

DOE Patents [OSTI]

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W.; Pinkel, Daniel; Kallioniemi, Ol'li-Pekka; Kallioniemi, Anne; Sakamoto, Masaru

2006-10-03T23:59:59.000Z

35

Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same  

DOE Patents [OSTI]

The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

Brown, Kimberly; Harris, Paul; Zaretsky, Elizabeth; Re, Edward; Vlasenko, Elena; McFarland, Keith; Lopez de Leon, Alfredo

2012-10-16T23:59:59.000Z

36

7-9/99 Neuman Chapter 23 Nucleic Acids  

E-Print Network [OSTI]

7-9/99 Neuman Chapter 23 0 Chapter 23 Nucleic Acids from Organic Chemistry by Robert C. Neuman, Jr. Professor of Chemistry, emeritus University of California, Riverside orgchembyneuman@yahoo.com ://web.chem.ucsb.edu/~neuman/orgchembyneuman/> Chapter Outline of the Book

Reed, Christopher A.

37

Multiple Sequence Alignments of Partially Coding Nucleic Acid Sequences  

E-Print Network [OSTI]

Multiple Sequence Alignments of Partially Coding Nucleic Acid Sequences Roman R. Stocsits1 , Ivo L Fe Institute, 1399 Hyde Park Rd., Santa Fe NM 87501, USA Email: Roman R. Stocsits - roman of the available sequence data was pre- sented very recently [12]. SARGLSSTVSLGQFEHWSPR NARNLSDTVS

Stadler, Peter F.

38

Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same  

DOE Patents [OSTI]

The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

Brown, Kimberly; Harris, Paul; Zaretsky, Elizabeth; Re, Edward; Vlasenko, Elena; McFarland, Keith; Lopez de Leon, Alfredo

2014-09-30T23:59:59.000Z

39

Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same  

SciTech Connect (OSTI)

The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

Brown, Kimberly; Harris, Paul; Zaretsky, Elizabeth; Re, Edward; Vlasenko, Elena; McFarland, Keith; Lopez de Leon, Alfredo

2010-06-22T23:59:59.000Z

40

Mosaic protein and nucleic acid vaccines against hepatitis C virus  

DOE Patents [OSTI]

The invention relates to immunogenic compositions useful as HCV vaccines. Provided are HCV mosaic polypeptide and nucleic acid compositions which provide higher levels of T-cell epitope coverage while minimizing the occurrence of unnatural and rare epitopes compared to natural HCV polypeptides and consensus HCV sequences.

Yusim, Karina; Korber, Bette T. M.; Kuiken, Carla L.; Fischer, William M.

2013-06-11T23:59:59.000Z

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Cell cycle nucleic acids, polypeptides and uses thereof  

DOE Patents [OSTI]

The invention provides isolated nucleic acids and their encoded proteins that are involved in cell cycle regulation. The invention further provides recombinant expression cassettes, host cells, transgenic plants, and antibody compositions. The present invention provides methods and compositions relating to altering cell cycle protein content, cell cycle progression, cell number and/or composition of plants.

Gordon-Kamm, William J. (Urbandale, IA); Lowe, Keith S. (Johnston, IA); Larkins, Brian A. (Tucson, AZ); Dilkes, Brian R. (Tucson, AZ); Sun, Yuejin (Westfield, IN)

2007-08-14T23:59:59.000Z

42

Universal nucleic acids sample preparation method for cells, spores and their mixture  

DOE Patents [OSTI]

The present invention relates to a method for extracting nucleic acids from biological samples. More specifically the invention relates to a universal method for extracting nucleic acids from unidentified biological samples. An advantage of the presently invented method is its ability to effectively and efficiently extract nucleic acids from a variety of different cell types including but not limited to prokaryotic or eukaryotic cells and/or recalcitrant organisms (i.e. spores). Unlike prior art methods which are focused on extracting nucleic acids from vegetative cell or spores, the present invention effectively extracts nucleic acids from spores, multiple cell types or mixtures thereof using a single method. Important that the invented method has demonstrated an ability to extract nucleic acids from spores and vegetative bacterial cells with similar levels effectiveness. The invented method employs a multi-step protocol which erodes the cell structure of the biological sample, isolates, labels, fragments nucleic acids and purifies labeled samples from the excess of dye.

Bavykin, Sergei (Darien, IL)

2011-01-18T23:59:59.000Z

43

Method and apparatus for staining immobilized nucleic acids  

DOE Patents [OSTI]

A method for staining immobilized nucleic acids includes the steps of affixing DNA probes to a solid substrate, moving target DNA material into proximity with the DNA probes, whereby the target DNA hybridized with specific ones of the DNA probes, and moving a fluorescent dye into proximity with the hybridized target DNA, whereby the fluorescent dye binds to the hybridized DNA to enable subsequent detection of fluorescence.

Ramsey, J. Michael (Knoxville, TN); Foote, Robert S. (Oak Ridge, TN); Jacobson, Stephen C. (Knoxville, TN)

2000-01-01T23:59:59.000Z

44

Nucleic acids encoding human trithorax protein  

DOE Patents [OSTI]

In accordance with the present invention, there is provided an isolated peptide having the characteristics of human trithorax protein (as well as DNA encoding same, antisense DNA derived therefrom and antagonists therefor). The invention peptide is characterized by having a DNA binding domain comprising multiple zinc fingers and at least 40% amino acid identity with respect to the DNA binding domain of Drosophila trithorax protein and at least 70% conserved sequence with respect to the DNA binding domain of Drosophila trithorax protein, and wherein said peptide is encoded by a gene located at chromosome 11 of the human genome at q23. Also provided are methods for the treatment of subject(s) suffering from immunodeficiency, developmental abnormality, inherited disease, or cancer by administering to said subject a therapeutically effective amount of one of the above-described agents (i.e., peptide, antagonist therefor, DNA encoding said peptide or antisense DNA derived therefrom). Also provided is a method for the diagnosis, in a subject, of immunodeficiency, developmental abnormality, inherited disease, or cancer associated with disruption of chromosome 11 at q23.

Evans, Glen A. (Encinitas, CA); Djabali, Malek (Marseilles, FR); Selleri, Licia (Del Mar, CA); Parry, Pauline (San Diego, CA)

2001-01-01T23:59:59.000Z

45

Nucleic acid modifications in bacterial pathogens - impact on pathogenesis, diagnosis, and therapy  

E-Print Network [OSTI]

Nucleic acids are subject to extensive chemical modification by all organisms. These modifications display incredible structural diversity, and some are essential for survival. Intriguingly, several of these modifications ...

Russell, Brandon S. (Brandon Skylur)

2014-01-01T23:59:59.000Z

46

BGL7 beta-glucosidase and nucleic acids encoding the same  

DOE Patents [OSTI]

The present invention provides a novel .beta.-glucosidase nucleic acid sequence, designated bgl7, and the corresponding BGL7 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL7, recombinant BGL7 proteins and methods for producing the same.

Dunn-Coleman, Nigel; Ward, Michael

2014-03-25T23:59:59.000Z

47

BGL7 beta-glucosidase and nucleic acids encoding the same  

DOE Patents [OSTI]

The present invention provides a novel .beta.-glucosidase nucleic acid sequence, designated bgl7, and the corresponding BGL7 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL7, recombinant BGL7 proteins and methods for producing the same.

Dunn-Coleman, Nigel; Ward, Michael

2013-01-29T23:59:59.000Z

48

BGL6 beta-glucosidase and nucleic acids encoding the same  

DOE Patents [OSTI]

The present invention provides a novel .beta.-glucosidase nucleic acid sequence, designated bgl6, and the corresponding BGL6 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL6, recombinant BGL6 proteins and methods for producing the same.

Dunn-Coleman, Nigel; Ward, Michael

2014-03-04T23:59:59.000Z

49

BGL6 .beta.-glucosidase and nucleic acids encoding the same  

DOE Patents [OSTI]

The present invention provides a novel .beta.-glucosidase nucleic acid sequence, designated bgl6, and the corresponding BGL6 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL6, recombinant BGL6 proteins and methods for producing the same.

Dunn-Coleman, Nigel; Ward, Michael

2012-10-02T23:59:59.000Z

50

BGL4 beta-glucosidase and nucleic acids encoding the same  

DOE Patents [OSTI]

The present invention provides a novel .beta.-glucosidase nucleic acid sequence, designated bgl4, and the corresponding BGL4 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL4, recombinant BGL4 proteins and methods for producing the same.

Dunn-Coleman, Nigel (Los Gatos, CA) [Los Gatos, CA; Goedegebuur, Frits (Vlaardingen, NL) [Vlaardingen, NL; Ward, Michael (San Francisco, CA) [San Francisco, CA; Yao, Jian (Sunnyvale, CA) [Sunnyvale, CA

2008-01-22T23:59:59.000Z

51

BGL3 beta-glucosidase and nucleic acids encoding the same  

DOE Patents [OSTI]

The present invention provides a novel .beta.-glucosidase nucleic acid sequence, designated bgl3, and the corresponding BGL3 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL3, recombinant BGL3 proteins and methods for producing the same.

Dunn-Coleman, Nigel (Los Gatos, CA); Goedegebuur, Frits (Vlaardingen, NL); Ward, Michael (San Francisco, CA); Yao, Jian (Sunnyvale, CA)

2008-04-01T23:59:59.000Z

52

BGL5 .beta.-glucosidase and nucleic acids encoding the same  

DOE Patents [OSTI]

The present invention provides a novel .beta.-glucosidase nucleic acid sequence, designated bgl5, and the corresponding BGL5 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL5, recombinant BGL5 proteins and methods for producing the same.

Dunn-Coleman, Nigel (Los Gatos, CA); Goedegebuur, Frits (Vlaardingen, NL); Ward, Michael (San Francisco, CA); Yao, Jian (Sunnyvale, CA)

2008-03-18T23:59:59.000Z

53

BGL3 beta-glucosidase and nucleic acids encoding the same  

DOE Patents [OSTI]

The present invention provides a novel .beta.-glucosidase nucleic acid sequence, designated bgl3, and the corresponding BGL3 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL3, recombinant BGL3 proteins and methods for producing the same.

Dunn-Coleman, Nigel (Los Gatos, CA); Goedegebuur, Frits (Vlaardingen, NL); Ward, Michael (San Francisco, CA); Yao, Jian (Sunnyvale, CA)

2011-06-14T23:59:59.000Z

54

BGL4 beta-glucosidase and nucleic acids encoding the same  

DOE Patents [OSTI]

The present invention provides a novel .beta.-glucosidase nucleic acid sequence, designated bgl4, and the corresponding BGL4 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL4, recombinant BGL4 proteins and methods for producing the same.

Dunn-Coleman, Nigel (Los Gatos, CA); Goedegebuur, Frits (Vlaardingen, NL); Ward, Michael (San Francisco, CA); Yao, Jian (Sunnyvale, CA)

2011-12-06T23:59:59.000Z

55

BGL3 beta-glucosidase and nucleic acids encoding the same  

DOE Patents [OSTI]

The present invention provides a novel .beta.-glucosidase nucleic acid sequence, designated bgl3, and the corresponding BGL3 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL3, recombinant BGL3 proteins and methods for producing the same.

Dunn-Coleman, Nigel (Los Gatos, CA); Goedegebuur, Frits (Vlaardingen, NL); Ward, Michael (San Francisco, CA); Yao, Jian (Sunnyvale, CA)

2007-09-25T23:59:59.000Z

56

BGL3 beta-glucosidase and nucleic acids encoding the same  

DOE Patents [OSTI]

The present invention provides a novel .beta.-glucosidase nucleic acid sequence, designated bgl3, and the corresponding BGL3 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL3, recombinant BGL3 proteins and methods for producing the same.

Dunn-Coleman, Nigel; Goedegebuur, Frits; Ward, Michael; Yao, Jian

2012-10-30T23:59:59.000Z

57

BGL7 beta-glucosidase and nucleic acids encoding the same  

DOE Patents [OSTI]

The present invention provides a novel .beta.-glucosidase nucleic acid sequence, designated bgl7, and the corresponding BGL7 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL7, recombinant BGL7 proteins and methods for producing the same.

Dunn-Coleman, Nigel (Los Gatos, CA); Ward, Michael (San Francisco, CA)

2008-08-05T23:59:59.000Z

58

Nucleic acid sequence detection using multiplexed oligonucleotide PCR  

DOE Patents [OSTI]

Methods for rapidly detecting single or multiple sequence alleles in a sample nucleic acid are described. Provided are all of the oligonucleotide pairs capable of annealing specifically to a target allele and discriminating among possible sequences thereof, and ligating to each other to form an oligonucleotide complex when a particular sequence feature is present (or, alternatively, absent) in the sample nucleic acid. The design of each oligonucleotide pair permits the subsequent high-level PCR amplification of a specific amplicon when the oligonucleotide complex is formed, but not when the oligonucleotide complex is not formed. The presence or absence of the specific amplicon is used to detect the allele. Detection of the specific amplicon may be achieved using a variety of methods well known in the art, including without limitation, oligonucleotide capture onto DNA chips or microarrays, oligonucleotide capture onto beads or microspheres, electrophoresis, and mass spectrometry. Various labels and address-capture tags may be employed in the amplicon detection step of multiplexed assays, as further described herein.

Nolan, John P. (Santa Fe, NM); White, P. Scott (Los Alamos, NM)

2006-12-26T23:59:59.000Z

59

Structure and function of circadian clock proteins and deuterium isotope effects in nucleic acid hydrogen bonds  

E-Print Network [OSTI]

-terminal domain. Hydrogen bonds are of paramount importance in nucleic acid structure and function. Here we show that changes in the width and anharmonicity of vibrational potential energy wells of hydrogen bonded groups can be measured in nucleic acids and can...

Vakonakis, Ioannis

2005-08-29T23:59:59.000Z

60

The present invention relates to automated methods of introducing multiple nucleic acid sequences into one or more target cells.  

DOE Patents [OSTI]

The present invention relates to automated methods of introducing multiple nucleic acid sequences into one or more target cells.

Church, George M. (Brookline, MA); Wang, Harris H. (Cambridge, MA); Isaacs, Farren J. (Brookline, MA)

2012-04-10T23:59:59.000Z

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Understanding barriers to efficient nucleic acid delivery with bioresponsive block copolymers  

E-Print Network [OSTI]

The delivery of nucleic acids has the potential to revolutionize medicine by allowing previously untreatable diseases to be clinically addressed. Viral delivery systems have been held back by immunogenicity and toxicity ...

Bonner, Daniel Kenneth

2012-01-01T23:59:59.000Z

62

Studies toward biomimetic claisen condensation using nucleic acid templates and ribozyme catalysis  

E-Print Network [OSTI]

Many different experimental approaches were attempted to achieve carbon-carbon bond formation by nucleic acid template-directed reactions and ribozyme catalysis as potential lipid synthesizing machineries in the RNA world. A novel biomimetic...

Ryu, Youngha

2005-08-29T23:59:59.000Z

63

Stable nitrogen isotope measurements of marine bacterial proteins and nucleic acids: tracers of microbial activity  

E-Print Network [OSTI]

and nucleic acids from cultures and environmental samples were analyzed to determine if protein []15N reliably reflects whole cell []15N. In batch culture experiments, the net fractionation between Vibrio harveyi and bacterial protein extracts, varied as a...

Kovacs, Jeffrey Paul

1996-01-01T23:59:59.000Z

64

Development of polymer and lipid materials for enhanced delivery of nucleic acids and proteins  

E-Print Network [OSTI]

The development of synthetic vectors enabling efficient intracellular delivery of macromolecular therapeutics such as nucleic acids and proteins could potentially catalyze the clinical translation of many gene and protein-based ...

Eltoukhy, Ahmed Atef

2013-01-01T23:59:59.000Z

65

Point of Attachment and Sequence of Immobilized Peptide-Acridine Conjugates Control Affinity for Nucleic Acids  

E-Print Network [OSTI]

for Nucleic Acids Coby B. Carlson and Peter A. Beal* Department of Chemistry, UniVersity of Utah, 315 South) was constructed * To whom correspondence should be addressed. E-mail: beal@ chemistry.chem.utah.edu. Figure 1

Beal, Peter A.

66

Method for producing labeled single-stranded nucleic acid probes  

DOE Patents [OSTI]

Disclosed is a method for the introduction of unidirectional deletions in a cloned DNA segment. More specifically, the method comprises providing a recombinant DNA construct comprising a DNA segment of interest inserted in a cloning vector, the cloning vector having an f1 endonuclease recognition sequence adjacent to the insertion site of the DNA segment of interest. The recombinant DNA construct is then contacted with the protein pII encoded by gene II of phage f1 thereby generating a single-stranded nick. The nicked DNA is then contacted with E. coli Exonuclease III thereby expanding the single-stranded nick into a single-stranded gap. The single-stranded gapped DNA is then contacted with a single-strand-specific endonuclease thereby producing a linearized DNA molecule containing a double-stranded deletion corresponding in size to the single-stranded gap. The DNA treated in this manner is then incubated with DNA ligase under conditions appropriate for ligation. Also disclosed is a method for producing single-stranded DNA probes. In this embodiment, single-stranded gapped DNA, produced as described above, is contacted with a DNA polymerase in the presence of labeled nucleotides to fill in the gap. This DNA is then linearized by digestion with a restriction enzyme which cuts outside the DNA segment of interest. The product of this digestion is then denatured to produce a labeled single-stranded nucleic acid probe.

Dunn, John J. (Bellport, NY); Quesada, Mark A. (Middle Island, NY); Randesi, Matthew (Upton, NY)

1999-10-19T23:59:59.000Z

67

Methods and kits for nucleic acid analysis using fluorescence resonance energy transfer  

DOE Patents [OSTI]

A method for detecting the presence of a target nucleotide or sequence of nucleotides in a nucleic acid is disclosed. The method is comprised of forming an oligonucleotide labeled with two fluorophores on the nucleic acid target site. The doubly labeled oligonucleotide is formed by addition of a singly labeled dideoxynucleoside triphosphate to a singly labeled polynucleotide or by ligation of two singly labeled polynucleotides. Detection of fluorescence resonance energy transfer upon denaturation indicates the presence of the target. Kits are also provided. The method is particularly applicable to genotyping.

Kwok, Pui-Yan (Clayton, MO); Chen, Xiangning (St. Louis, MO)

1999-01-01T23:59:59.000Z

68

Structural aspects of catalytic mechanisms of endonucleases and their binding to nucleic acids  

SciTech Connect (OSTI)

Endonucleases (EC 3.1) are enzymes of the hydrolase class that catalyze the hydrolytic cleavage of deoxyribonucleic and ribonucleic acids at any region of the polynucleotide chain. Endonucleases are widely used both in biotechnological processes and in veterinary medicine as antiviral agents. Medical applications of endonucleases in human cancer therapy hold promise. The results of X-ray diffraction studies of the spatial organization of endonucleases and their complexes and the mechanism of their action are analyzed and generalized. An analysis of the structural studies of this class of enzymes showed that the specific binding of enzymes to nucleic acids is characterized by interactions with nitrogen bases and the nucleotide backbone, whereas the nonspecific binding of enzymes is generally characterized by interactions only with the nucleic-acid backbone. It should be taken into account that the specificity can be modulated by metal ions and certain low-molecular-weight organic compounds. To test the hypotheses about specific and nonspecific nucleic-acid-binding proteins, it is necessary to perform additional studies of atomic-resolution three-dimensional structures of enzyme-nucleic-acid complexes by methods of structural biology.

Zhukhlistova, N. E.; Balaev, V. V.; Lyashenko, A. V.; Lashkov, A. A., E-mail: alashkov83@gmail.com [Russian Academy of Sciences, Shubnikov Institute of Crystallography (Russian Federation)

2012-05-15T23:59:59.000Z

69

Nucleosides, Nucleotides, and Nucleic Acids, 25:915, 2006 Copyright C Taylor & Francis Group, LLC  

E-Print Network [OSTI]

Nucleosides, Nucleotides, and Nucleic Acids, 25:9­15, 2006 Copyright C Taylor & Francis Group, LLC-LABELED NUCLEOTIDE SPACER ARM ON INCORPORATION BY THERMOPHILIC DNA POLYMERASES Christopher J. Lacenere 2 Division incor- porate fluorescently labeled nucleotides sequentially was analyzed by a gel based primer

Stoltz, Brian M.

70

Nucleic acid molecules conferring enhanced ethanol tolerance and microorganisms having enhanced tolerance to ethanol  

DOE Patents [OSTI]

The present invention provides isolated nucleic acid molecules which encode a mutant acetaldehyde-CoA/alcohol dehydrogenase or mutant alcohol dehydrogenase and confer enhanced tolerance to ethanol. The invention also provides related expression vectors, genetically engineered microorganisms having enhanced tolerance to ethanol, as well as methods of making and using such genetically modified microorganisms for production of biofuels based on fermentation of biomass materials.

Brown, Steven; Guss, Adam; Yang, Shihui; Karpinets, Tatiana; Lynd, Lee; Shao, Xiongjun

2014-01-14T23:59:59.000Z

71

Nucleic acids encoding modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins  

DOE Patents [OSTI]

The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

Haynes, Barton F. (Durham, NC); Gao, Feng (Durham, NC); Korber, Bette T. (Los Alamos, NM); Hahn, Beatrice H. (Birmingham, AL); Shaw, George M. (Birmingham, AL); Kothe, Denise (Birmingham, AL); Li, Ying Ying (Hoover, AL); Decker, Julie (Alabaster, AL); Liao, Hua-Xin (Chapel Hill, NC)

2011-12-06T23:59:59.000Z

72

Supplementary Materials: A Partition Function Algorithm for Interacting Nucleic Acid Strands  

E-Print Network [OSTI]

nucleic acid strands by R and S. Strand R is indexed from 1 to LR, and S is indexed from 1 to LS both in 5 to 3 direction. Note that the two strands interact in opposite directions, e.g. R in 5 3 with S in 3 to the ith nucleotide in R and S by iR and iS respectively. An intramolecular base pair between

Will, Sebastian

73

Nucleic Acid Encoding A Lectin-Derived Progenitor Cell Preservation Factor  

DOE Patents [OSTI]

The invention relates to an isolated nucleic acid molecule that encodes a protein that is effective to preserve progenitor cells, such as hematopoietic progenitor cells. The nucleic acid comprises a sequence defined by SEQ ID NO:1, a homolog thereof, or a fragment thereof. The encoded protein has an amino acid sequence that comprises a sequence defined by SEQ ID NO:2, a homolog thereof, or a fragment thereof that contains an amino acid sequence TNNVLQVT. Methods of using the encoded protein for preserving progenitor cells in vitro, ex vivo, and in vivo are also described. The invention, therefore, include methods such as myeloablation therapies for cancer treatment wherein myeloid reconstitution is facilitated by means of the specified protein. Other therapeutic utilities are also enabled through the invention, for example, expanding progenitor cell populations ex vivo to increase chances of engraftation, improving conditions for transporting and storing progenitor cells, and facilitating gene therapy to treat and cure a broad range of life-threatening hematologic diseases.

Colucci, M. Gabriella (Dugenta, IT); Chrispeels, Maarten J. (La Jolla, CA); Moore, Jeffrey G. (New York, NY)

2001-10-30T23:59:59.000Z

74

Method for high-volume sequencing of nucleic acids: random and directed priming with libraries of oligonucleotides  

DOE Patents [OSTI]

Random and directed priming methods for determining nucleotide sequences by enzymatic sequencing techniques, using libraries of primers of lengths 8, 9 or 10 bases, are disclosed. These methods permit direct sequencing of nucleic acids as large as 45,000 base pairs or larger without the necessity for subcloning. Individual primers are used repeatedly to prime sequence reactions in many different nucleic acid molecules. Libraries containing as few as 10,000 octamers, 14,200 nonamers, or 44,000 decamers would have the capacity to determine the sequence of almost any cosmid DNA. Random priming with a fixed set of primers from a smaller library can also be used to initiate the sequencing of individual nucleic acid molecules, with the sequence being completed by directed priming with primers from the library. In contrast to random cloning techniques, a combined random and directed priming strategy is far more efficient. 2 figs.

Studier, F.W.

1995-04-18T23:59:59.000Z

75

Method for high-volume sequencing of nucleic acids: random and directed priming with libraries of oligonucleotides  

DOE Patents [OSTI]

Random and directed priming methods for determining nucleotide sequences by enzymatic sequencing techniques, using libraries of primers of lengths 8, 9 or 10 bases, are disclosed. These methods permit direct sequencing of nucleic acids as large as 45,000 base pairs or larger without the necessity for subcloning. Individual primers are used repeatedly to prime sequence reactions in many different nucleic acid molecules. Libraries containing as few as 10,000 octamers, 14,200 nonamers, or 44,000 decamers would have the capacity to determine the sequence of almost any cosmid DNA. Random priming with a fixed set of primers from a smaller library can also be used to initiate the sequencing of individual nucleic acid molecules, with the sequence being completed by directed priming with primers from the library. In contrast to random cloning techniques, a combined random and directed priming strategy is far more efficient.

Studier, F. William (Stony Brook, NY)

1995-04-18T23:59:59.000Z

76

Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes  

DOE Patents [OSTI]

A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from Alicyclobacillus acidocaldarius and encoding a polypeptide involved in at least partially degrading, cleaving, transporting, metabolizing, or removing polysaccharides, cellulose, lignocellulose, hemicellulose, lignin, starch, sugars, sugar oligomers, carbohydrates, complex carbohydrates, chitin, heteroxylans, glycosides, xylan-, glucan-, galactan-, or mannan-decorating groups; and at least one nucleic acid sequence and/or at least one recombinant nucleic acid encoding a polypeptide involved in fermenting sugar molecules to a product. Additionally, enzymatic and/or proteinaceous extracts may be isolated from one or more genetically modified organisms. The extracts are utilized to convert biomass into a product. Further provided are methods of converting biomass into products comprising: placing the genetically modified organism and/or enzymatic extracts thereof in fluid contact with polysaccharides, cellulose, lignocellulose, hemicellulose, lignin, starch, sugars, sugar oligomers, carbohydrates, complex carbohydrates, chitin, heteroxylans, glycosides, and/or xylan-, glucan-, galactan-, or mannan-decorating groups.

Thompson, David N; Apel, William A; Thompson, Vicki S; Ward, Thomas E

2014-04-08T23:59:59.000Z

77

Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes  

DOE Patents [OSTI]

A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from Alicyclobacillus acidocaldarius and encoding a polypeptide involved in at least partially degrading, cleaving, transporting, metabolizing, or removing polysaccharides, cellulose, lignocellulose, hemicellulose, lignin, starch, sugars, sugar oligomers, carbohydrates, complex carbohydrates, chitin, heteroxylans, glycosides, xylan-, glucan-, galactan-, or mannan-decorating groups; and at least one nucleic acid sequence and/or at least one recombinant nucleic acid encoding a polypeptide involved in fermenting sugar molecules to a product. Additionally, enzymatic and/or proteinaceous extracts may be isolated from one or more genetically modified organisms. The extracts are utilized to convert biomass into a product. Further provided are methods of converting biomass into products comprising: placing the genetically modified organism and/or enzymatic extracts thereof in fluid contact with polysaccharides, cellulose, lignocellulose, hemicellulose, lignin, starch, sugars, sugar oligomers, carbohydrates, complex carbohydrates, chitin, heteroxylans, glycosides, and/or xylan-, glucan-, galactan-, or mannan-decorating groups.

Thompson, David N; Apel, William A; Thompson, Vicki S; Ward, Thomas E

2013-07-23T23:59:59.000Z

78

Aptamer- and nucleic acid enzyme-based systems for simultaneous detection of multiple analytes  

DOE Patents [OSTI]

The present invention provides aptamer- and nucleic acid enzyme-based systems for simultaneously determining the presence and optionally the concentration of multiple analytes in a sample. Methods of utilizing the system and kits that include the sensor components are also provided. The system includes a first reactive polynucleotide that reacts to a first analyte; a second reactive polynucleotide that reacts to a second analyte; a third polynucleotide; a fourth polynucleotide; a first particle, coupled to the third polynucleotide; a second particle, coupled to the fourth polynucleotide; and at least one quencher, for quenching emissions of the first and second quantum dots, coupled to the first and second reactive polynucleotides. The first particle includes a quantum dot having a first emission wavelength. The second particle includes a second quantum dot having a second emission wavelength different from the first emission wavelength. The third polynucleotide and the fourth polynucleotide are different.

Lu, Yi (Champaign, IL); Liu, Juewen (Albuquerque, NM)

2011-11-15T23:59:59.000Z

79

Site-Selective Binding of Nanoparticles to Double-Stranded DNA via Peptide Nucleic Acid "Invasion"  

SciTech Connect (OSTI)

We demonstrate a novel method for by-design placement of nano-objects along double-stranded (ds) DNA. A molecular intercalator, designed as a peptide nucleic acid (PNA)-DNA chimera, is able to invade dsDNA at the PNA-side due to the hybridization specificity between PNA and one of the duplex strands. At the same time, the single-stranded (ss) DNA tail of the chimera, allows for anchoring of nano-objects that have been functionalized with complementary ssDNA. The developed method is applied for interparticle attachment and for the fabrication of particle clusters using a dsDNA template. This method significantly broadens the molecular toolbox for constructing nanoscale systems by including the most conventional not yet utilized DNA motif, double helix DNA.

Stadler, A.L.; van der Lelie, D.; Sun, D.; Maye, M. M.; Gang, O.

2011-04-01T23:59:59.000Z

80

Quantification of false positive reduction in nucleic acid purification on hemorrhagic fever DNA.  

SciTech Connect (OSTI)

Columbia University has developed a sensitive highly multiplexed system for genetic identification of nucleic acid targets. The primary obstacle to implementing this technology is the high rate of false positives due to high levels of unbound reporters that remain within the system after hybridization. The ability to distinguish between free reporters and reporters bound to targets limits the use of this technology. We previously demonstrated a new electrokinetic method for binary separation of kb pair long DNA molecules and oligonucleotides. The purpose of this project 99864 is to take these previous demonstrations and further develop the technique and hardware for field use. Specifically, our objective was to implement separation in a heterogeneous sample (containing target DNA and background oligo), to perform the separation in a flow-based device, and to develop all of the components necessary for field testing a breadboard prototype system.

James, Conrad D.; Pohl, Kenneth Roy; Derzon, Mark Steven; McClain, Jaime; Achyuthan, Komandoor

2006-11-01T23:59:59.000Z

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Repeat sequence chromosome specific nucleic acid probes and methods of preparing and using  

DOE Patents [OSTI]

A primer directed DNA amplification method to isolate efficiently chromosome-specific repeated DNA wherein degenerate oligonucleotide primers are used is disclosed. The probes produced are a heterogeneous mixture that can be used with blocking DNA as a chromosome-specific staining reagent, and/or the elements of the mixture can be screened for high specificity, size and/or high degree of repetition among other parameters. The degenerate primers are sets of primers that vary in sequence but are substantially complementary to highly repeated nucleic acid sequences, preferably clustered within the template DNA, for example, pericentromeric alpha satellite repeat sequences. The template DNA is preferably chromosome-specific. Exemplary primers and probes are disclosed. The probes of this invention can be used to determine the number of chromosomes of a specific type in metaphase spreads, in germ line and/or somatic cell interphase nuclei, micronuclei and/or in tissue sections. Also provided is a method to select arbitrarily repeat sequence probes that can be screened for chromosome-specificity. 18 figs.

Weier, H.U.G.; Gray, J.W.

1995-06-27T23:59:59.000Z

82

BIO 548--NUCLEIC ACIDS AND PROTEIN SYNTHESIS--FALL 2014 Coursemaster  

E-Print Network [OSTI]

in organic chemistry, Cell Biology and Genetics is also very useful. Formal lectures in all areas of nucleic for the course. The listed books are recommended as sources of background information for the lectures

83

Nucleic Acid-Based Detection and Identification of Bacterial and Fungal Plant Pathogens - Final Report  

SciTech Connect (OSTI)

The threat to American interests from terrorists is not limited to attacks against humans. Terrorists might seek to inflict damage to the U.S. economy by attacking our agricultural sector. Infection of commodity crops by bacterial or fungal crop pathogens could adversely impact U.S. agriculture, either directly from damage to crops or indirectly from damage to our ability to export crops suspected of contamination. Recognizing a terrorist attack against U.S. agriculture, to be able to prosecute the terrorists, is among the responsibilities of the members of Hazardous Material Response Unit (HMRU) of the Federal Bureau of Investigation (FBI). Nucleic acid analysis of plant pathogen strains by the use of polymerase chain reaction (PCR) amplification techniques is a powerful method for determining the exact identity of pathogens, as well as their possible region of origin. This type of analysis, however, requires that PCR assays be developed specific to each particular pathogen strain, and analysis protocols developed that are specific to the particular instrument used for detection. The objectives of the work described here were threefold: 1) to assess the potential terrorist threat to U.S. agricultural crops, 2) to determine whether suitable assays exist to monitor that threat, and 3) where assays are needed for priority plant pathogen threats, to modify or develop those assays for use by specialists at the HMRU. The assessment of potential threat to U.S. commodity crops and the availability of assays for those threats were described in detail in the Technical Requirements Document (9) and will be summarized in this report. This report addresses development of specific assays identified in the Technical Requirements Document, and offers recommendations for future development to ensure that HMRU specialists will be prepared with the PCR assays they need to protect against the threat of economic terrorism.

Kingsley, Mark T.

2001-03-13T23:59:59.000Z

84

Nucleic Acid-Based Detection and Identification of Bacterial and Fungal Plant Pathogens - Final Report  

SciTech Connect (OSTI)

The threat to American interests from terrorists is not limited to attacks against humans. Terrorists might seek to inflict damage to the U.S. economy by attacking our agricultural sector. Infection of commodity crops by bacterial or fungal crop pathogens could adversely impact U.S. agriculture, either directly from damage to crops or indirectly from damage to our ability to export crops suspected of contamination. Recognizing a terrorist attack against U.S. agriculture, to be able to prosecute the terrorists, is among the responsibilities of the members of Hazardous Material Response Unit (HMRU) of the Federal Bureau of Investigation (FBI). Nucleic acid analysis of plant pathogen strains by the use of polymerase chain reaction (PCR) amplification techniques is a powerful method for determining the exact identity of pathogens, as well as their possible region of origin. This type of analysis, however, requires that PCR assays be developed specific to each particular pathogen strain, an d analysis protocols developed that are specific to the particular instrument used for detection. The objectives of the work described here were threefold: (1) to assess the potential terrorist threat to U.S. agricultural crops, (2) to determine whether suitable assays exist to monitor that threat, and (3) where assays are needed for priority plant pathogen threats, to modify or develop those assays for use by specialists at the HMRU. The assessment of potential threat to U.S. commodity crops and the availability of assays for those threats were described in detail in the Technical Requirements Document (9) and will be summarized in this report. This report addresses development of specific assays identified in the Technical Requirements Document, and offers recommendations for future development to ensure that HMRU specialists will be prepared with the PCR assays they need to protect against the threat of economic terrorism.

Kingsley, Mark T

2001-03-13T23:59:59.000Z

85

Human retroviruses and AIDS 1996. A compilation and analysis of nucleic acid and amino acid sequences  

SciTech Connect (OSTI)

This compendium and the accompanying floppy diskettes are the result of an effort to compile and rapidly publish all relevant molecular data concerning the human immunodeficiency viruses (HIV) and related retroviruses. The scope of the compendium and database is best summarized by the five parts that it comprises: (1) Nuclear Acid Alignments and Sequences; (2) Amino Acid Alignments; (3) Analysis; (4) Related Sequences; and (5) Database Communications. Information within all the parts is updated throughout the year on the Web site, http://hiv-web.lanl.gov. While this publication could take the form of a review or sequence monograph, it is not so conceived. Instead, the literature from which the database is derived has simply been summarized and some elementary computational analyses have been performed upon the data. Interpretation and commentary have been avoided insofar as possible so that the reader can form his or her own judgments concerning the complex information. In addition to the general descriptions of the parts of the compendium, the user should read the individual introductions for each part.

Myers, G.; Foley, B.; Korber, B. [eds.] [Los Alamos National Lab., NM (United States). Theoretical Div.] [eds.; Los Alamos National Lab., NM (United States). Theoretical Div.; Mellors, J.W. [ed.] [Univ. of Pittsburgh, PA (United States)] [ed.; Univ. of Pittsburgh, PA (United States); Jeang, K.T. [ed.] [National Institutes of Health, Bethesda, MD (United States). Molecular Virology Section] [ed.; National Institutes of Health, Bethesda, MD (United States). Molecular Virology Section; Wain-Hobson, S. [Pasteur Inst., Paris (France)] [ed.] [Pasteur Inst., Paris (France); ed.

1997-04-01T23:59:59.000Z

86

Does Water Play a Structural Role in the Folding of Small Nucleic Acids? Eric J. Sorin,* Young Min Rhee,* and Vijay S. Pande*yz  

E-Print Network [OSTI]

Does Water Play a Structural Role in the Folding of Small Nucleic Acids? Eric J. Sorin,* Young Min Rhee,* and Vijay S. Pande*yz Departments of *Chemistry and y Structural Biology, and z Stanford character of the solvent. Here we consider what role the discrete properties of water and ions play

Sorin, Eric J.

87

Supplementary Information An In Vitro Translation, Selection, and Amplification System for Peptide Nucleic Acids  

E-Print Network [OSTI]

% trifluoroacetic acid in water for 10 min at room temperature; (iv) reverse-phase HPLC purification of the MMTS1 Supplementary Information An In Vitro Translation, Selection, and Amplification System available reagents and solvents were purchased from Aldrich and used without further purification. All PNA

Liu, David R.

88

Accurate small and wide angle x-ray scattering profiles from atomic models of proteins and nucleic acids  

SciTech Connect (OSTI)

A new method is introduced to compute X-ray solution scattering profiles from atomic models of macromolecules. The three-dimensional version of the Reference Interaction Site Model (RISM) from liquid-state statistical mechanics is employed to compute the solvent distribution around the solute, including both water and ions. X-ray scattering profiles are computed from this distribution together with the solute geometry. We describe an efficient procedure for performing this calculation employing a Lebedev grid for the angular averaging. The intensity profiles (which involve no adjustable parameters) match experiment and molecular dynamics simulations up to wide angle for two proteins (lysozyme and myoglobin) in water, as well as the small-angle profiles for a dozen biomolecules taken from the BioIsis.net database. The RISM model is especially well-suited for studies of nucleic acids in salt solution. Use of fiber-diffraction models for the structure of duplex DNA in solution yields close agreement with the observed scattering profiles in both the small and wide angle scattering (SAXS and WAXS) regimes. In addition, computed profiles of anomalous SAXS signals (for Rb{sup +} and Sr{sup 2+}) emphasize the ionic contribution to scattering and are in reasonable agreement with experiment. In cases where an absolute calibration of the experimental data at q = 0 is available, one can extract a count of the excess number of waters and ions; computed values depend on the closure that is assumed in the solution of the Ornstein–Zernike equations, with results from the Kovalenko–Hirata closure being closest to experiment for the cases studied here.

Nguyen, Hung T. [BioMaPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey 08854 (United States); Pabit, Suzette A.; Meisburger, Steve P.; Pollack, Lois [School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853 (United States); Case, David A., E-mail: case@biomaps.rutgers.edu [BioMaPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey 08854 (United States); Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854 (United States)

2014-12-14T23:59:59.000Z

89

Nucleic acid molecules encoding isopentenyl monophosphate kinase, and methods of use  

DOE Patents [OSTI]

A cDNA encoding isopentenyl monophosphate kinase (IPK) from peppermint (Mentha x piperita) has been isolated and sequenced, and the corresponding amino acid sequence has been determined. Accordingly, an isolated DNA sequence (SEQ ID NO:1) is provided which codes for the expression of isopentenyl monophosphate kinase (SEQ ID NO:2), from peppermint (Mentha x piperita). In other aspects, replicable recombinant cloning vehicles are provided which code for isopentenyl monophosphate kinase, or for a base sequence sufficiently complementary to at least a portion of isopentenyl monophosphate kinase DNA or RNA to enable hybridization therewith. In yet other aspects, modified host cells are provided that have been transformed, transfected, infected and/or injected with a recombinant cloning vehicle and/or DNA sequence encoding isopentenyl monophosphate kinase. Thus, systems and methods are provided for the recombinant expression of the aforementioned recombinant isopentenyl monophosphate kinase that may be used to facilitate its production, isolation and purification in significant amounts. Recombinant isopentenyl monophosphate kinase may be used to obtain expression or enhanced expression of isopentenyl monophosphate kinase in plants in order to enhance the production of isopentenyl monophosphate kinase, or isoprenoids derived therefrom, or may be otherwise employed for the regulation or expression of isopentenyl monophosphate kinase, or the production of its products.

Croteau, Rodney B. (Pullman, WA); Lange, Bernd M. (Pullman, WA)

2001-01-01T23:59:59.000Z

90

Nucleic and amino acid sequences relating to a novel transketolase, and methods for the expression thereof  

DOE Patents [OSTI]

cDNAs encoding 1-deoxyxylulose-5-phosphate synthase from peppermint (Mentha piperita) have been isolated and sequenced, and the corresponding amino acid sequences have been determined. Accordingly, isolated DNA sequences (SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7) are provided which code for the expression of 1-deoxyxylulose-5-phosphate synthase from plants. In another aspect the present invention provides for isolated, recombinant DXPS proteins, such as the proteins having the sequences set forth in SEQ ID NO:4, SEQ ID NO:6 and SEQ ID NO:8. In other aspects, replicable recombinant cloning vehicles are provided which code for plant 1-deoxyxylulose-5-phosphate synthases, or for a base sequence sufficiently complementary to at least a portion of 1-deoxyxylulose-5-phosphate synthase DNA or RNA to enable hybridization therewith. In yet other aspects, modified host cells are provided that have been transformed, transfected, infected and/or injected with a recombinant cloning vehicle and/or DNA sequence encoding a plant 1-deoxyxylulose-5-phosphate synthase. Thus, systems and methods are provided for the recombinant expression of the aforementioned recombinant 1-deoxyxylulose-5-phosphate synthase that may be used to facilitate its production, isolation and purification in significant amounts. Recombinant 1-deoxyxylulose-5-phosphate synthase may be used to obtain expression or enhanced expression of 1-deoxyxylulose-5-phosphate synthase in plants in order to enhance the production of 1-deoxyxylulose-5-phosphate, or its derivatives such as isopentenyl diphosphate (BP), or may be otherwise employed for the regulation or expression of 1-deoxyxylulose-5-phosphate synthase, or the production of its products.

Croteau, Rodney Bruce (Pullman, WA); Wildung, Mark Raymond (Colfax, WA); Lange, Bernd Markus (Pullman, WA); McCaskill, David G. (Pullman, WA)

2001-01-01T23:59:59.000Z

91

Nucleic acid isolation  

DOE Patents [OSTI]

A method is provided for isolating DNA from eukaryotic cell and flow sorted chromosomes. When DNA is removed from chromosome and cell structure, detergent and proteolytic digestion products remain with the DNA. These products can be removed with organic extraction, but the process steps associated with organic extraction reduces the size of DNA fragments available for experimental use. The present process removes the waste products by dialyzing a solution containing the DNA against a solution containing polyethylene glycol (PEG). The waste products dialyze into the PEG leaving isolated DNA. The remaining DNA has been prepared with fragments containing more than 160 kb. The isolated DNA has been used in conventional protocols without effect on the protocol.

Longmire, J.L.; Lewis, A.K.; Hildebrand, C.E.

1988-01-21T23:59:59.000Z

92

Nucleic acid isolation process  

DOE Patents [OSTI]

A method is provided for isolating DNA from eukaryotic cell and flow sorted chromosomes. When DNA is removed from chromosome and cell structure, detergent and proteolytic digestion products remain with the DNA. These products can be removed with organic extraction, but the process steps associated with organic extraction reduce the size of DNA fragments available for experimental use. The present process removes the waste products by dialyzing a solution containing the DNA against a solution containing polyethylene glycol (PEG). The waste products dialyze into the PEG leaving isolated DNA. The remaining DNA has been prepared with fragments containing more than 160 kb. The isolated DNA has been used in conventional protocols without affect on the protocol.

Longmire, Jonathan L. (Los Alamos, NM); Lewis, Annette K. (La Jolla, CA); Hildebrand, Carl E. (Los Alamos, NM)

1990-01-01T23:59:59.000Z

93

Nucleic acid biosensors  

DOE Patents [OSTI]

Sensors comprising aptazymes capable of detecting the presence and concentration of effectors, as well as methods of using such sensors, are disclosed.

Lu, Yi (Champaign, IL); Liu, Juewen (Urbana, IL)

2009-11-03T23:59:59.000Z

94

Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3;#8242;-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides  

SciTech Connect (OSTI)

The synthesis, biophysical, structural, and biological properties of both isomers of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides are reported. Synthesis of the FHNA and Ara-FHNA thymine phosphoramidites was efficiently accomplished starting from known sugar precursors. Optimal RNA affinities were observed with a 3'-fluorine atom and nucleobase in a trans-diaxial orientation. The Ara-FHNA analog with an equatorial fluorine was found to be destabilizing. However, the magnitude of destabilization was sequence-dependent. Thus, the loss of stability is sharply reduced when Ara-FHNA residues were inserted at pyrimidine-purine (Py-Pu) steps compared to placement within a stretch of pyrimidines (Py-Py). Crystal structures of A-type DNA duplexes modified with either monomer provide a rationalization for the opposing stability effects and point to a steric origin of the destabilization caused by the Ara-FHNA analog. The sequence dependent effect can be explained by the formation of an internucleotide C-F {hor_ellipsis} H-C pseudo hydrogen bond between F3' of Ara-FHNA and C8-H of the nucleobase from the 3'-adjacent adenosine that is absent at Py-Py steps. In animal experiments, FHNA-modified antisense oligonucleotides formulated in saline showed a potent downregulation of gene expression in liver tissue without producing hepatotoxicity. Our data establish FHNA as a useful modification for antisense therapeutics and also confirm the stabilizing influence of F(Py) {hor_ellipsis} H-C(Pu) pseudo hydrogen bonds in nucleic acid structures.

Egli, Martin; Pallan, Pradeep S.; Allerson, Charles R.; Prakash, Thazha P.; Berdeja, Andres; Yu, Jinghua; Lee, Sam; Watt, Andrew; Gaus, Hans; Bhat, Balkrishen; Swayze, Eric E.; Seth, Punit P. (Isis Pharm.); (Vanderbilt)

2012-03-16T23:59:59.000Z

95

Nucleic Acids Research doi:10.1093/nar/gkn305  

E-Print Network [OSTI]

server for rapidly generating accurate 3D protein structures using only assigned nuclear magnetic no NOE and/or J-coupling data to perform its calculations. CS23D accepts chemical shift files in either. Tests conducted on more than 100 proteins from the BioMagResBank indicate that CS23D converges (i

Lin, Guohui

96

Nucleic Acids Research doi:10.1093/nar/gkn465  

E-Print Network [OSTI]

is a histone acetyltransferase implicated in the regulation of transcriptional silencing, and ORC is the six the temperature sensitivity of the ORC mutants orc2-1 and orc5-1. Moreover, sas2D and orc2-1 have a synthetic and orc5-1 have a synthetic effect on transcriptional silencing at the HMR locus. Moreover, we demon

Bi, Xin

97

acid adenine dinucleotide: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Theoretical Determination of One-Electron Oxidation Potentials for Nucleic Acid Bases Brian T potentials for N-methyl substituted nucleic acid bases guanine, adenine, cytosine,...

98

Structural Rationalization of a Large Difference in RNA Affinity Despite a Small Difference in Chemistry between Two 2'-O-Modified Nucleic Acid Analogs  

SciTech Connect (OSTI)

Chemical modification of nucleic acids at the 2'-position of ribose has generated antisense oligonucleotides (AONs) with a range of desirable properties. Electron-withdrawing substituents such as 2'-O-[2-(methoxy)ethyl] (MOE) confer enhanced RNA affinity relative to that of DNA by conformationally preorganizing an AON for pairing with the RNA target and by improving backbone hydration. 2'-Substitution of the ribose has also been shown to increase nuclease resistance and cellular uptake via changes in lipophilicity. Interestingly, incorporation of either 2'-O-[2-(methylamino)-2-oxoethyl]- (NMA) or 2'-O-(N-methylcarbamate)-modified (NMC) residues into AONs has divergent effects on RNA affinity. Incorporation of 2'-O-NMA-T considerably improves RNA affinity while incorporation of 2'-O-NMC-T drastically reduces RNA affinity. Crystal structures at high resolution of A-form DNA duplexes containing either 2'-O-NMA-T or 2'-O-NMC-T shed light on the structural origins of the surprisingly large difference in stability given the relatively minor difference in chemistry between NMA and NMC. NMA substituents adopt an extended conformation and use either their carbonyl oxygen or amino nitrogen to trap water molecules between phosphate group and sugar. The conformational properties of NMA and the observed hydration patterns are reminiscent of those found in the structures of 2'-O-MOE-modified RNA. Conversely, the carbonyl oxygen of NMC and O2 of T are in close contact, providing evidence that an unfavorable electrostatic interaction and the absence of a stable water structure are the main reasons for the loss in thermodynamic stability as a result of incorporation of 2'-O-NMC-modified residues.

Pattanayek, R.; Sethaphong, L.; Pan, C.; Prhavc, M.; Prakash, T.P.; Manoharan, M.; Egli, M. (Tennessee); (Isis Pharmaceuticals Inc.); (Alnylam Pharmaceuticals,); (Vanderbilt)

2010-03-08T23:59:59.000Z

99

Final Scientific/Technical Report, DE-FG02-06ER64171, Integrated Nucleic Acid System for In-Field Monitoring of Microbial Community Dynamics and Metabolic Activity – Subproject to Co-PI Eric E. Roden  

SciTech Connect (OSTI)

This report summarizes research conducted in conjunction with a project entitled “Integrated Nucleic Acid System for In-Field Monitoring of Microbial Community Dynamics and Metabolic Activity”, which was funded through the Integrative Studies Element of the former NABIR Program (now the Environmental Remediation Sciences Program) within the Office of Biological and Environmental Research. Dr. Darrell Chandler (originally at Argonne National Laboratory, now with Akonni Biosystems) was the overall PI/PD for the project. The overall project goals were to (1) apply a model iron-reducer and sulfate-reducer microarray and instrumentation systems to sediment and groundwater samples from the Scheibe et al. FRC Area 2 field site, UMTRA sediments, and other DOE contaminated sites; (2) continue development and expansion of a 16S rRNA/rDNA¬-targeted probe suite for microbial community dynamics as new sequences are obtained from DOE-relevant sites; and (3) address the fundamental molecular biology and analytical chemistry associated with the extraction, purification and analysis of functional genes and mRNA in environmental samples. Work on the UW subproject focused on conducting detailed batch and semicontinuous culture reactor experiments with uranium-contaminated FRC Area 2 sediment. The reactor experiments were designed to provide coherent geochemical and microbiological data in support of microarray analyses of microbial communities in Area 2 sediments undergoing biostimulation with ethanol. A total of four major experiments were conducted (one batch and three semicontinuous culture), three of which (the batch and two semicontinuous culture) provided samples for DNA microarray analysis. A variety of other molecular analyses (clone libraries, 16S PhyloChip, RT-PCR, and T-RFLP) were conducted on parallel samples from the various experiments in order to provide independent information on microbial community response to biostimulation.

Eric E. Roden

2009-07-08T23:59:59.000Z

100

E-Print Network 3.0 - acid house juergen Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Division of Cell Biology and Immunology, HZI Summary: , Karst U, Fischer E, Wehland J, Jansch L. Nucleic Acids Res. 2006; 34(Database issue):D402-6. Jenzora A... Research (HZI)...

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Human Retroviruses and AIDS. A compilation and analysis of nucleic acid and amino acid sequences: I--II; III--V  

SciTech Connect (OSTI)

This compendium and the accompanying floppy diskettes are the result of an effort to compile and rapidly publish all relevant molecular data concerning the human immunodeficiency viruses (HIV) and related retroviruses. The scope of the compendium and database is best summarized by the five parts that it comprises: (I) HIV and SIV Nucleotide Sequences; (II) Amino Acid Sequences; (III) Analyses; (IV) Related Sequences; and (V) Database Communications. Information within all the parts is updated at least twice in each year, which accounts for the modes of binding and pagination in the compendium.

Myers, G.; Korber, B. [eds.] [Los Alamos National Lab., NM (United States)] [eds.; Los Alamos National Lab., NM (United States); Wain-Hobson, S. [ed.] [Laboratory of Molecular Retrovirology, Pasteur Inst.] [ed.; Laboratory of Molecular Retrovirology, Pasteur Inst.; Smith, R.F. [ed.] [Baylor Coll. of Medicine, Houston, TX (United States). Dept. of Pharmacology] [ed.; Baylor Coll. of Medicine, Houston, TX (United States). Dept. of Pharmacology; Pavlakis, G.N. [ed.] [National Cancer Inst., Frederick, MD (United States). Cancer Research Facility] [ed.; National Cancer Inst., Frederick, MD (United States). Cancer Research Facility

1993-12-31T23:59:59.000Z

102

Nucleic Acids Research, 1993, Vol. 21, No. 9 2247-2248 The nucleosome repeat length of Kluyveromyces lactis is  

E-Print Network [OSTI]

Sorbitol, 20 mM Pipes, 0.1 mM CaCl2, pH = 6.3), and resuspended in the remaining liquid. The suspensions were each added to 25 ml of Ficoll-PMSF solution (9% Ficoll 4000, 20 mM Pipes, 0.5 mM CaCl2, pH = 6

103

2001 Oxford University Press Nucleic Acids Research, 2001, Vol. 29, No. 22 46634673 Importance of the conserved nucleotides around the  

E-Print Network [OSTI]

of the conserved nucleotides around the tRNA-like structure of Escherichia coli transfer- messenger RNA for protein nucleotide stretches 16­20 and 333­335 seriously impair protein tagging with only minor changes nucleotides next to the tRNA-like portion is proposed. Overall, the highly conserved nucleotides around the t

Paris-Sud XI, Université de

104

Nucleic Acids Research, 1994, Vol. 22, No. 11 1981 -1987 Interaction between the first and last nucleotides of  

E-Print Network [OSTI]

nucleotides of pre-mRNA introns is a determinant of 3' splice site selection in S.cerevisiae Guillaume be reactivated by a G to C substitution of the last intron nucleotide. These results demonstrate that the inter- action between the first and last intron nucleotides is a conserved feature of nuclear pre-mRNA splicing

Chanfreau, Guillaume

105

1997 Oxford University Press49945002 Nucleic Acids Research, 1997, Vol. 25, No. 24 Information analysis of Fis binding sites  

E-Print Network [OSTI]

analysis of Fis binding sites Paul N. Hengen1, Stacy L. Bartram1,2,+, Lisa E. Stewart1 and Thomas D 30, 1997 ABSTRACT Originally discovered in the bacteriophage Mu DNA inversion system gin, Fis (Factor for Fis to locate its binding sites, we collected a set of 60 experimentally defined wild-type Fis DNA

Schneider, Thomas D.

106

1997 Oxford University Press 13391346Nucleic Acids Research, 1997, Vol. 25, No. 7 Mechanisms of triplex-caused polymerization arrest  

E-Print Network [OSTI]

of triplex-caused polymerization arrest Andrey S. Krasilnikov1,2, Igor G. Panyutin3, George M. Samadashwily1/purine/purine triplexes are known to inhibit DNA polymerization. Here we have studied the mech- anisms of this inhibition temperatures and ambient conditions make them a barrier to polymerization. INTRODUCTION During the last decade

Mirkin, Sergei

107

1996 Oxford University Press 713720Nucleic Acids Research, 1996, Vol. 24, No. 4 Atomic force microscopy of long and short  

E-Print Network [OSTI]

of DNA can be reliably imaged and identified and also what substrates and methods of sample preparation technique for observing DNA. The AFM can image conformations of DNA molecules (3­5), nucleosome Corporation; Wood Dale, IL) and cleaved with tape immediately before use. Silicon. Oxidized silicon substrates

Hansma, Helen

108

1998 Oxford University Press 7379Nucleic Acids Research, 1998, Vol. 26, No. 1 SGD: Saccharomyces Genome Database  

E-Print Network [OSTI]

, Erich T. Hester, Yankai Jia, Gail Juvik, TaiYun Roe, Mark Schroeder, Shuai Weng and David Botstein

Botstein, David

109

Geochemical Rate/RNA Integration Study (GRIST): A Pilot Field Experiment for Inter-Calibration of Biogeochemistry and Nucleic Acid Measurements Final Report  

SciTech Connect (OSTI)

The Geochemical Rate/RNA Integration Study (GRIST) project sought to correlate biogeochemical flux rates with measurements of gene expression and mRNA abundance to demonstrate the application of molecular approaches to estimate the presence and magnitude of a suite of biogeochemical processes. The study was headed by Lee Kerkhoff of Rutgers University. In this component of the GRIST study, we characterized ambient nutrient concentrations and measured uptake rates for dissolved inorganic nitrogen (DIN, ammonium, nitrate and nitrite) and dissolved organic nitrogen (urea and dissolved free amino acids) during two diel studies at the Long-Term Ecosystem Observatory (LEO-15) on the New Jersey continental shelf.

Bronk, Deborah

2007-01-08T23:59:59.000Z

110

Nucleic acids encoding a cellulose binding domain  

DOE Patents [OSTI]

A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production thereof. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques.

Shoseyov, Oded (Karmey Yosef, IL); Shpiegl, Itai (Rehovot, IL); Goldstein, Marc A. (Davis, CA); Doi, Roy H. (Davis, CA)

1996-01-01T23:59:59.000Z

111

Nucleic acids encoding a cellulose binding domain  

DOE Patents [OSTI]

A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques. 15 figs.

Shoseyov, O.; Shpiegl, I.; Goldstein, M.A.; Doi, R.H.

1996-03-05T23:59:59.000Z

112

Ramon Eritja Nucleic Acid Chemistry Group  

E-Print Network [OSTI]

, IQAC-CSIC, CIBER-BBN DNA and RNA in Biophysics #12;DNA and RNA Synthesis tetrazol + (CH2)2(CH2)2 R R R

Ritort, Felix

113

Diagnostic method employing MSH2 nucleic acids  

DOE Patents [OSTI]

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.

de la Chapelle, Albert (Helsingfors, FI); Vogelstein, Bert (Baltimore, MD); Kinzler, Kenneth W. (Baltimore, MD)

1997-01-01T23:59:59.000Z

114

Diagnostic method employing MSH2 nucleic acids  

DOE Patents [OSTI]

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +}(RER{sup +}) tumor cells. 19 figs.

Chapelle, A. de la; Vogelstein, B.; Kinzler, K.W.

1997-12-02T23:59:59.000Z

115

Fatty acid-producing hosts  

DOE Patents [OSTI]

Described are hosts for overproducing a fatty acid product such as a fatty acid. The hosts include an exogenous nucleic acid encoding a thioesterase and, optionally, an exogenous nucleic acid encoding an acetyl-CoA carboxylase, wherein an acyl-CoA synthetase in the hosts are functionally delected. The hosts prefereably include the nucleic acid encoding the thioesterase at an intermediate copy number. The hosts are preferably recominantly stable and growth-competent at 37.degree. C. Methods of producing a fatty acid product comprising culturing such hosts at 37.degree. C. are also described.

Pfleger, Brian F; Lennen, Rebecca M

2013-12-31T23:59:59.000Z

116

E-Print Network 3.0 - acids amino acids Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

State University Collection: Biology and Medicine 77 CHE 427627 THE ORGANIC CHEMISTRY OF BIOLOGICAL MOLECULES Summary: macromolecules: carbohydrates, amino acids, nucleic...

117

E-Print Network 3.0 - acid amino acid Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

State University Collection: Biology and Medicine 77 CHE 427627 THE ORGANIC CHEMISTRY OF BIOLOGICAL MOLECULES Summary: macromolecules: carbohydrates, amino acids, nucleic...

118

E-Print Network 3.0 - anthranilic acid derivatives Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

This acid has been used... -specific nucleic acid ligands via affinity ... Source: Beal, Peter A. - Department of Chemistry, University of Utah Collection: Chemistry 26 Direct...

119

acid rain research: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in rain falling over industrial decline of fish populations in the lakes of southern Norway and traced the problem to acid rain. Similar Jacob, Daniel J. 5 Long range transport...

120

acids structures applied: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Treatment of software French, James C. 5 Parsing nucleic acid pseudoknotted secondary structure: algorithm and applications Computer Technologies and Information Sciences...

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

acid biosensor based: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

biosensors of nucleic acids and proteins for point- of-care (POC. The merger of microfluidics and advanced biosensor technolo- gies offers new promises for POC diagnostics...

122

158 BrainResearch,359(1985) 158-165 Unfocused Laser Illumination Kills Dye-Targeted Mouse Neurons  

E-Print Network [OSTI]

158 BrainResearch,359(1985) 158-165 Elsevier BRE 11224 Unfocused Laser Illumination Kills Dye March 12th, 1985) Key words:laser-lesioning -- dye-targeting -- central nervous system-- in vitro by propidium iodide (PI), a fluorescent dye that leaks through damaged membranes and binds to nucleic acids

123

Nucleic Acids Research, 2007, Vol. 35, Web Server issue W357W362 doi:10.1093/nar/gkm231  

E-Print Network [OSTI]

://pipe.scs.fsu.edu. To illustrate the utility of these web servers, cons-PPISP and DISPLAR predictions are used to construct of the web servers and illustrate their utility by a structural model, built from predictions of the web similar designs. The input in each case consists of data for a list of residues. In WESA, the list

Weston, Ken

124

Published online 26 November 2007 Nucleic Acids Research, 2008, Vol. 36, No. 2 451461 doi:10.1093/nar/gkm1067  

E-Print Network [OSTI]

September 7, 2007; Revised November 11, 2007; Accepted November 12, 2007 ABSTRACT The Chlorella virus RNA poxviruses, reoviruses, alphaviruses, baculoviruses, West Nile virus and Chlorella virus PBCV-1 encode

Perreault, Jean-Pierre

125

This is a pre-print of a manuscript that will appear in: Nucleic Acids Research, 2005, Vol 33, Oxford University Press.  

E-Print Network [OSTI]

Function Prediction Brett Poulin*, Duane Szafron, Russell Greiner, Roman Eisner and Paul Lu *poulin@cs.ualberta.ca BIOINFORMATICS I We use Markov chains as a pre-processing filter for HMM software (HMMER)[2], removing the most

Alberta, University of

126

Published online 11 August 2009 Nucleic Acids Research, 2009, Vol. 37, No. 18 61616173 doi:10.1093/nar/gkp597  

E-Print Network [OSTI]

. N. M. Glover1, * 1 Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7 whom correspondence should be addressed. Tel: +1 780 492 2136; Fax: +1 780 492 0886; Email: mark.glover

Glover, Mark

127

Research Report Oral supplementation with docosahexaenoic acid and  

E-Print Network [OSTI]

cognitive ability with a diet enriched in DHA. Various cellular mechanisms have been proposed for DHA phosphatides and in pre- and post-synaptic proteins within the hippocampus. Hence, oral DHA may promote, is synthesized from its precursor -linolenic acid, which cannot be synthesized in mammals (mammals lack

Wurtman, Richard

128

acid research frontiers: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

(NSF), Department of Energy (DOE), National Institutes of Health (NIH) and NASA, are funding the necessary cyberinfrastructure to empower e-science research and allied education...

129

E-Print Network 3.0 - acids research database Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

5 > >> 1 The Peptaibol Database: a database for sequences and structures of naturally occurring peptaibols Summary: , Database issue D593D594 DOI: 10.1093nargkh077 Nucleic...

130

E-Print Network 3.0 - acid chelate derivatives Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Ca21 and Mg21 by phosphates and nucleic acids. We describe coordination chemistry Source: Williams, Loren - School of Chemistry and Biochemistry, Georgia Institute of Technology...

131

E-Print Network 3.0 - acid hybridization probes Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

tion to hybridization and wash... or the extent to which nucleic acid ... Source: Kelly, John J. - Department of Biology, Loyola University Chicago Collection: Environmental...

132

E-Print Network 3.0 - acid regulates gene Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

DNA binding domain or partner domain type Summary: of the Bipartite response regulator FIS-like Nucleic acid-binding proteins Distribution of DBDs in the TF... R + + + + + ...

133

E-Print Network 3.0 - acid negatively regulates Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

DNA binding domain or partner domain type Summary: of the Bipartite response regulator FIS-like Nucleic acid-binding proteins Distribution of DBDs in the TF... R + + + + + ...

134

E-Print Network 3.0 - acid catabolic pathway Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

metabolism of nutrients1 Summary: , and cell cultures to investigate the interconnectivity of the pathways of macronutrient and nucleic acid... -labeled car- bon skeletons...

135

Plant fatty acid hydroxylase  

DOE Patents [OSTI]

The present invention relates to the identification of nucleic acid sequences and constructs, and methods related thereto, and the use of these sequences and constructs to produce genetically modified plants for the purpose of altering the composition of plant oils, waxes and related compounds.

Somerville, Chris (Portola Valley, CA); van de Loo, Frank (Lexington, KY)

2000-01-01T23:59:59.000Z

136

Thermal and acid tolerant beta-xylosidases, genes encoding, related organisms, and methods  

DOE Patents [OSTI]

Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius and variations thereof are provided. Further provided are methods of at least partially degrading xylotriose and/or xylobiose using isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius and variations thereof.

Thompson, David N. (Idaho Falls, ID); Thompson, Vicki S. (Idaho Falls, ID); Schaller, Kastli D. (Ammon, ID); Apel, William A. (Jackson, WY); Lacey, Jeffrey A. (Idaho Falls, ID); Reed, David W. (Idaho Falls, ID)

2011-04-12T23:59:59.000Z

137

Thermal and acid tolerant beta xylosidases, arabinofuranosidases, genes encoding, related organisms, and methods  

DOE Patents [OSTI]

Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius and variations thereof are provided. Further provided are methods of at least partially degrading xylotriose, xylobiose, and/or arabinofuranose-substituted xylan using isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius and variations thereof.

Thompson, David N; Thompson, Vicki S; Schaller, Kastli D; Apel, William A; Reed, David W; Lacey, Jeffrey A

2013-04-30T23:59:59.000Z

138

Targeting unique nucleic acid structures with small molecules  

E-Print Network [OSTI]

2 min and then flash cooling on ice for 2 min. Incubated atfor 2 min then flash cooling on ice for 2 min. The extendedminutes, followed by flash cooling on ice for 2 minutes. The

Tam, Victor Kin-man

2007-01-01T23:59:59.000Z

139

Targeting unique nucleic acid structures with small molecules  

E-Print Network [OSTI]

of mono- and disubstitued anthraquinone derivatives with anat opposite ends of the anthraquinone scaffold are employed.

Tam, Victor Kin-man

2007-01-01T23:59:59.000Z

140

E-Print Network 3.0 - acid pdb entries Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

, nucleic acids, and other biological macro- molecules 1-3. The PDB has a 27-year history of service... entries include amino acid or nucle- ... Source: Sussman, Joel L. -...

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

E-Print Network 3.0 - acid utilization final Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

active with 18:1. In plants containing... nucleic acids were resuspended in water. Lithium chloride was then added to a final concentration of 2 m... Fatty Acids1 Hangsik Moon2...

142

Producing dicarboxylic acids using polyketide synthases  

DOE Patents [OSTI]

The present invention provides for a polyketide synthase (PKS) capable of synthesizing a dicarboxylic acid (diacid). Such diacids include diketide-diacids and triketide-diacids. The invention includes recombinant nucleic acid encoding the PKS, and host cells comprising the PKS. The invention also includes methods for producing the diacids.

Katz, Leonard; Fortman, Jeffrey L; Keasling, Jay D

2013-10-29T23:59:59.000Z

143

Research, development, and demonstration of lead-acid batteries for electric-vehicle propulsion. Annual report for 1982  

SciTech Connect (OSTI)

Research programs on lead-acid batteries are reported that cover active materials utilization, active material integrity, and some technical support projects. Processing problems were encountered and corrected. Components and materials, a lead-plastic composite grid, cell designs, and deliverables are described. Cell testing is discussed, as well as battery subsystems, including fuel gage, thermal management, and electrolyte circulation. (LEW)

Bowman, D.E.

1983-08-01T23:59:59.000Z

144

Research, development and demonstration of lead-acid batteries for electric vehicle propulsion. Annual report, 1979  

SciTech Connect (OSTI)

This report describes work performed from October 1, 1978 to September 30, 1979. The approach for development of both the Improved State-of-the-Art (ISOA) and Advanced lead-acid batteries is three pronged. This approach concentrates on simultaneous optimization of battery design, materials, and manufacturing processing. The 1979 fiscal year saw the achievement of significant progress in the program. Some of the major accomplishments of the year are outlined. 33 figures, 13 tables. (RWR)

Not Available

1980-06-01T23:59:59.000Z

145

Research, development, and demonstration of lead-acid batteries for electric vehicle propulsion. Annual report, 1980  

SciTech Connect (OSTI)

The progress and status of Eltra's Electric Vehicle Battery Program during FY-80 are presented under five divisional headings: Research on Components and Processes; Development of Cells and Modules for Electric Vehicle Propulsion; Sub-Systems; Pilot Line Production of Electric Vehicle Battery Prototypes; and Program Management.

Not Available

1981-03-01T23:59:59.000Z

146

Research, development, and demonstration of advanced lead-acid batteries for utility load leveling. Final report  

SciTech Connect (OSTI)

An advanced lead-acid storage battery has been developed to the preprototype cell and module design stage. Accelerated tests on full-size plates in 3, 5, and 17-plate cell sizes predict a cycle life goal of 4000 cycles at 80% depth-of-discharge can be achieved at 25/sup 0/C on a 2 cycle per day regime. One 6-cell 36 kwh and two 3-cell 18 kwh modules of cells in series were assembled and delivered to the ANL/NBTL for utility application and accelerated cycling tests. Each module is equipped with a low cost tray, automatic watering system, and air-lift pumps for increased acid circulation in each cell. Positive grid corrosion was measured in 5-plate cells at 50 to 55/sup 0/C during 166 kAh continuous overcharge to qualify a grid alloy. Up to 60% weight loss was observed on one test alloy. With the qualified alloy catastrophic positive grid corrosion will not limit cell cycle life. An accelerated shallow cycle regime at room ambient tested 60 cell designs for the active material shedding failure mode. An anti-shedding active material additive was found to reduce positive active material shedding significantly and extend the cycle life of both the positive and the negative plate. An accelerated 2-deep cycle per day test regime at 70/sup 0/C with 80% DoD and 24% overcharge selected 10 of 60 cell designs with a predicted cycle life greater than 5000 equivalent 25/sup 0/C cycles. Equations relating cell design to deep cycle life were developed from the factorial tests on the 60 cells. Eight 35-plate preprototype cells are cycling at EXIDE to prove the room ambient cycle life predicted by the accelerated test at 70/sup 0/C. Cell, module and battery prices are projected, based on the 6 kwh preprototype cell design.

Not Available

1983-08-01T23:59:59.000Z

147

acid amplification test: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

amplification test First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Diagnostic Accuracy of Nucleic Acid...

148

Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production  

DOE Patents [OSTI]

The present disclosure provides novel beta-alanine/alpha ketoglutarate aminotransferase nucleic acid and protein sequences having increased biological activity. Also provided are cells containing such enzymes, as well as methods of their use, for example to produce malonyl semialdehyde and downstream products thereof, such as 3-hydroxypropionic acid and derivatives thereof.

Jessen, Holly Jean (Chanhassen, MN); Liao, Hans H. (Eden Prairie, MN); Gort, Steven John (Apple Valley, MN); Selifonova, Olga V. (Plymouth, MN)

2011-10-04T23:59:59.000Z

149

Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production  

SciTech Connect (OSTI)

The present disclosure provides novel beta-alanine/alpha ketoglutarate aminotransferase nucleic acid and protein sequences having increased biological activity. Also provided are cells containing such enzymes, as well as methods of their use, for example to produce malonyl semialdehyde and downstream products thereof, such as 3-hydroxypropionic acid and derivatives thereof.

Jessen, Holly Jean; Liao, Hans H; Gort, Steven John; Selifonova, Olga V

2014-11-18T23:59:59.000Z

150

The integrated microbial genomes (IMG) system in 2007: data content and analysis tool extensions  

E-Print Network [OSTI]

for genome annotation: PRIAM. Nucleic Acids Research 31 (EC numbers are computed using PRIAM (13), as a complement to

2008-01-01T23:59:59.000Z

151

UBC Centre for Blood Research: Fermentation Suite Brom A5 (F4) PDF.xls: FermentationProfile Air O2 rpm N2 Base Acid  

E-Print Network [OSTI]

UBC Centre for Blood Research: Fermentation Suite Brom A5 (F4) PDF.xls: FermentationProfile Air O2 rpm N2 Base Acid NH4OH Acetic Acid 8.6 16.0 Configuration 1 SP 4 - - - SP - 2 SP 3 0.000 Temp (oC) dO2 Fermentation (Hrs) pH rpm Temp Do OD CK (mg/50-L) MeOH (ml) dO2 (%)Temp (C) 40 20 60 80 0 100 6 8 4 2 0 10 28

Strynadka, Natalie

152

Xylanases, nucleic acids encoding them and methods for making and using them  

DOE Patents [OSTI]

The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal .beta.-1,4-xylosidic linkages or endo-.beta.-1,4-glucanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.

Gray, Kevin A; Dirmeier, Reinhard

2013-07-16T23:59:59.000Z

153

BGL7 beta-glucosidase and nucleic acids encoding the same  

DOE Patents [OSTI]

The present invention provides BGL7 polypeptides with the biological activity of a .beta.-glucosidase and a method of producing a recombinant enzyme having .beta.-glucosidase activity.

Dunn-Coleman, Nigel (Los Gatos, CA); Ward, Michael (San Francisco, CA)

2012-03-13T23:59:59.000Z

154

Nucleic acid encoding a self-assembling split-fluorescent protein system  

DOE Patents [OSTI]

The invention provides a protein labeling and detection system based on self-complementing fragments of fluorescent and chromophoric proteins. The system of the invention is exemplified with various combinations of self-complementing fragments derived from Aequorea victoria Green Fluorescent Protein (GFP), which are used to detect and quantify protein solubility in multiple assay formats, both in vitro and in vivo.

Waldo, Geoffrey S. (Santa Fe, NM); Cabantous, Stephanie (Los Alamos, NM)

2011-06-07T23:59:59.000Z

155

Nucleic acid encoding a self-assembling split-fluorescent protein system  

DOE Patents [OSTI]

The invention provides a protein labeling and detection system based on self-complementing fragments of fluorescent and chromophoric proteins. The system of the invention is exemplified with various combinations of self-complementing fragments derived from Aequorea victoria Green Fluorescent Protein (GFP), which are used to detect and quantify protein solubility in multiple assay formats, both in vitro and in vivo.

Waldo, Geoffrey S; Cabantous, Stephanie

2014-04-01T23:59:59.000Z

156

Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them  

DOE Patents [OSTI]

The invention provides polypeptides having any cellulolytic activity, e.g., a cellulase activity, a endoglucanase, a cellobiohydrolase, a beta-glucosidase, a xylanase, a mannanse, a .beta.-xylosidase, an arabinofuranosidase, and/or an oligomerase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having any cellulolytic activity, e.g., a cellulase activity, e.g., endoglucanase, cellobiohydrolase, beta-glucosidase, xylanase, mannanse, .beta.-xylosidase, arabinofuranosidase, and/or oligomerase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides having an oligomerase activity, e.g., enzymes that convert recalcitrant soluble oligomers to fermentable sugars in the saccharification of biomass. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural, food and feed processing and industrial contexts. The invention also provides compositions or products of manufacture comprising mixtures of enzymes comprising at least one enzyme of this invention.

Gray, Kevin A. (San Diego, CA); Zhao, Lishan (Emeryville, CA); Cayouette, Michelle H. (San Diego, CA)

2012-01-24T23:59:59.000Z

157

On-line microdialysis sample cleanup for electrospray ionization mass spectrometry of nucleic acid samples  

SciTech Connect (OSTI)

A major limitation of electrospray ionization mass spectrometry (ESI-MS) for oligonucleotide analysis arises due to sodium adduction, a problem that increases with molecular weight. Sodium adduction can preclude useful measurements when limited sample sizes prevent off-line cleanup. A novel and generally useful on-line microdialysis technique is described for the rapid (nearly 1-5 min) DNA sample cleanup for ESI-MS. Mass spectra of oligonucleotides of different size and sequence showing no significant sodium adduct peaks were obtained using the on-line microdialysis system with sodium chloride concentrations as high as 250 mM. Signal-to-noise ratios were also greatly enhanced compared to direct infusion of the original samples. By using ammonium acetate as the dialysis buffer, it was also found that the noncovalent association of double-stranded oligonucleotides could be preserved during the microdialysis process, allowing analysis by ESI-MS. 33 refs., 6 figs.

Liu, C.; Wu, Q.; Harms, A.C.; Smith, R.D. [Pacific Northwest National Lab., Richland, WA (United States)] [Pacific Northwest National Lab., Richland, WA (United States)

1996-09-15T23:59:59.000Z

158

Enhanced Functional Potential of Nucleic Acid Aptamer Libraries Patterned to Increase Secondary Structure  

E-Print Network [OSTI]

the formation of stem-loop structures without imposing any specific sequence or secondary structural requirement carbon-carbon bond formation,3,4 and oxidation or reduction.5 In addition to ac- celerating chemical

Liu, David R.

159

Detection of nucleic acids by graphene-based devices: A first-principles study  

SciTech Connect (OSTI)

Based on first-principles quantum transport calculations, we design a graphene-based biosensor device, which is composed of graphene nanoribbons electrodes and a biomolecule. It is found that when different nucleobases or poly nucleobase chains are located in the nanogap, the device presents completely different transport properties, showing different current informations. And the change of currents from 2 to 5 orders of magnitude for four different nucleobases suggests a great ability of discrimination by utilizing such a device. The physical mechanism of this phenomenon originates from their different chemical composition and structure. Moreover, we also explore the coupling effect of several neighboring bases and the size effect of the nanogap on transport properties. Our results show the possibility of rapid sequencing DNA by measuring such a transverse-current of the device, and provide a new idea for sequencing DNA.

Zhang, Hua [School of Physics and Electronics, Central South University, Changsha 410083 (China); School of Physics and Electronic Science, Changsha University of Science and Technology, Changsha 410114 (China); Xu, Hui, E-mail: xuhui@csu.edu.cn, E-mail: ouyangfp06@tsinghua.org.cn; Ni, Xiang; Lin Peng, Sheng; Liu, Qi; Ping OuYang, Fang, E-mail: xuhui@csu.edu.cn, E-mail: ouyangfp06@tsinghua.org.cn [School of Physics and Electronics, Central South University, Changsha 410083 (China)

2014-04-07T23:59:59.000Z

160

Nucleic acids encoding phloem small RNA-binding proteins and transgenic plants comprising them  

DOE Patents [OSTI]

The present invention provides a polynucleotide sequence encoding a component of the protein machinery involved in small RNA trafficking, Cucurbita maxima phloem small RNA-binding protein (CmPSRB 1), and the corresponding polypeptide sequence. The invention also provides genetic constructs and transgenic plants comprising the polynucleotide sequence encoding a phloem small RNA-binding protein to alter (e.g., prevent, reduce or elevate) non-cell autonomous signaling events in the plants involving small RNA metabolism. These signaling events are involved in a broad spectrum of plant physiological and biochemical processes, including, for example, systemic resistance to pathogens, responses to environmental stresses, e.g., heat, drought, salinity, and systemic gene silencing (e.g., viral infections).

Lucas, William J.; Yoo, Byung-Chun; Lough, Tony J.; Varkonyi-Gasic, Erika

2007-03-13T23:59:59.000Z

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Cellulases, nucleic acids encoding them and methods for making and using them  

DOE Patents [OSTI]

This invention relates to molecular and cellular biology and biochemistry. In one aspect, the invention provides polypeptides having cellulase activity, e.g., endoglucanase, cellobiohydrolase, mannanase and/or .beta.-glucosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides cellulase activity, e.g., endoglucanase, cellobiohydrolase, mannanase and/or .beta.-glucosidase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural, food and feed processing and industrial contexts.

Blum, David; Gemsch Cuenca, Joslin; Dycaico, Mark

2013-04-23T23:59:59.000Z

162

Y chromosome specific nucleic acid probe and method for determining the Y chromosome in situ  

DOE Patents [OSTI]

A method for producing a Y chromosome specific probe selected from highly repeating sequences on that chromosome is described. There is little or no nonspecific binding to autosomal and X chromosomes, and a very large signal is provided. Inventive primers allowing the use of PCR for both sample amplification and probe production are described, as is their use in producing large DNA chromosome painting sequences. 9 figs.

Gray, J.W.; Weier, H.U.

1998-11-24T23:59:59.000Z

163

Y chromosome specific nucleic acid probe and method for identifying the Y chromosome in SITU  

DOE Patents [OSTI]

A method for producing a Y chromosome specific probe selected from highly repeating sequences on that chromosome is described. There is little or no nonspecific binding to autosomal and X chromosomes, and a very large signal is provided. Inventive primers allowing the use of PCR for both sample amplification and probe production are described, as is their use in producing large DNA chromosome painting sequences. 9 figs.

Gray, J.W.; Weier, H.U.

1999-03-30T23:59:59.000Z

164

Probing structural heterogeneities and fluctuations of nucleic acids and denatured proteins  

E-Print Network [OSTI]

polyelec- trolytes and protein folding in particular, standsdynamics ? protein folding ? single-molecule ?uorescencestructure and dynamics. Protein folding is the most spec-

Laurence, T A; Kong, X X; Jager, M; Weiss, S

2005-01-01T23:59:59.000Z

165

A HANDHELD MAGNETIC SENSING PLATFORM FOR ANTIGEN AND NUCLEIC ACID DETECTION  

E-Print Network [OSTI]

of manufacturing development for superior reliability, scalability, and low-cost. The electrical details cable for communication and power. (b) Disposable Cartridge. The disposable cartridge consists of an electrically connected integrated circuit chip inside a polypropylene well. (c) Chip Surface after Immunoassay

Weinreb, Sander

166

MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes  

E-Print Network [OSTI]

is the addition and full optimization of all hydrogen atoms, bothpolar and nonpolar.The results are reported. The all-atom contact analysis (7) featured on the MOLPROBITY site provides a simple but powerful system uses the information from both hydro- gen bonding and all-atom steric compatibility to fully

Richardson, David

167

An unprecedented nucleic acid capture mechanism for excision of DNA damage  

SciTech Connect (OSTI)

DNA glycosylases that remove alkylated and deaminated purine nucleobases are essential DNA repair enzymes that protect the genome, and at the same time confound cancer alkylation therapy, by excising cytotoxic N3-methyladenine bases formed by DNA-targeting anticancer compounds. The basis for glycosylase specificity towards N3- and N7-alkylpurines is believed to result from intrinsic instability of the modified bases and not from direct enzyme functional group chemistry. Here we present crystal structures of the recently discovered Bacillus cereus AlkD glycosylase in complex with DNAs containing alkylated, mismatched and abasic nucleotides. Unlike other glycosylases, AlkD captures the extrahelical lesion in a solvent-exposed orientation, providing an illustration for how hydrolysis of N3- and N7-alkylated bases may be facilitated by increased lifetime out of the DNA helix. The structures and supporting biochemical analysis of base flipping and catalysis reveal how the HEAT repeats of AlkD distort the DNA backbone to detect non-Watson-Crick base pairs without duplex intercalation.

Rubinson, Emily H.; Prakasha Gowda, A.S.; Spratt, Thomas E.; Gold, Barry; Eichmanbrand, Brandt F. (Pitt); (Vanderbilt); (Penn)

2010-11-18T23:59:59.000Z

168

Single-molecule characterization and engineering of the surfaces of nucleic acid sensors  

E-Print Network [OSTI]

Diamond Nanopure water purification system was used.laboratory water purification system (18.2 M?·cm). In a

Josephs, Eric Alan

2013-01-01T23:59:59.000Z

169

Bioluminescence regenerative cycle (BRC) system: Theoretical considerations for nucleic acid quantification assays  

E-Print Network [OSTI]

. In the BRC system, pyrophosphate (PPi) molecules are released during biopolymerization and are counted

Hassibi, Arjang

170

Thermo-Biolithography: A Technique for Patterning Nucleic Acids and Proteins  

E-Print Network [OSTI]

fluorescent protein (using tyrosinase-initiated conjugation). Because gelatin can be applied and removed under

Rubloff, Gary W.

171

Structure-based model for light-harvesting properties of nucleic acid nanostructures  

E-Print Network [OSTI]

Programmed self-assembly of DNA enables the rational design of megadalton-scale macromolecular assemblies with sub-nanometer scale precision. These assemblies can be programmed to serve as structural scaffolds for secondary ...

Pan, Keyao

172

Type I Interferon is Not Just for Viruses: Cytosolic Sensing of Bacterial Nucleic Acids  

E-Print Network [OSTI]

in the recognition of Helicobacter pylori. Gastroenterologypneumophila, Helicobacter pylori, Francisella tularensis,the focus of Chapter 3. Helicobacter pylori is another gram-

Monroe, Kathryn McGee

2011-01-01T23:59:59.000Z

173

STRUCTURAL EFFECTS ON THE CIRCULAR DICHROISM OF ETHIDIUM-NUCLEIC ACID COMPLEXES  

E-Print Network [OSTI]

trup et al. (1978) examined dye binding with pdC- dG-dC-dG (2 dC-dG sites), pdC-dC-dG-dG (l dC-dG site), pdG-dG-dC-dC,1 dC-dG Site). For dye plus pdC-dG-dC-dG, both dC-dG sites

Dahl, Kenneth Steven

2013-01-01T23:59:59.000Z

174

Relations between intraruminal protein and nucleic acid synthesis and forms of urinary nitrogen excreted by sheep  

E-Print Network [OSTI]

alcohol. The samples were coils. cted in duplicates. An attempt was made to determine the volume of the rumen digesta and its passage out of the reticulo-rumen by usi. ng polyethylene glycol. An appropriate amount of polyethylene glycol (2 gm... procedure for poly- ethylene glycol it was not possible to determine the volume of the rumen digesta and rate of passage out of the reticulo-rumen. Fasting Animals At the end of all experimer. . tal feeding and collection periods, the rumens of two...

Razzaque, Md. Abdur

1967-01-01T23:59:59.000Z

175

Integration of On-chip Isotachophoresis and Functionalized Hydrogels for Enhanced-Sensitivity Nucleic Acid Detection  

E-Print Network [OSTI]

of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA *E-mail: juan purchased crown glass microfluidic chips (model NS260) and separate plastic chip caddies from Caliper Life of prepolymer mastermix, ITP buffers, and surface modification reagents Composition of our prepolymer is similar

Santiago, Juan G.

176

Quantitative prediction of 3D solution shape and flexibility of nucleic acid nanostructures  

E-Print Network [OSTI]

DNA nanotechnology enables the programmed synthesis of intricate nanometer-scale structures for diverse applications in materials and biological science. Precise control over the 3D solution shape and mechanical flexibility ...

Kilchherr, F.

177

Nature and Magnitude of Aromatic Stacking of Nucleic Acid Bases. | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the Contributions andDataNational Library of1, 2007 (next release3,3,Nature and Magnitude

178

Progress Report No. AT(11-1)-3083-6 RE: Nucleic Acids and Protein...  

Office of Scientific and Technical Information (OSTI)

Chiu, N., Chiu, A. & Suyama, Y. (1974). J. Mol. Biol. (In the ress). 4. Elder, K.T. & Smith, A.E. (1973). Proc. Natl. Acad. Sci. U.S.A . 70, .. 1 2823-2826. ' 5. Gillespie, D. &...

179

Balance of Attraction and Repulsion in Nucleic-Acid Base Stacking:  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series to someone6 M. Babzien, I. Ben-Zvi, P. Study ofJ U LY 2AVS trustee

180

Disposable and removable nucleic acid extraction and purification cartridges for automated flow-through systems  

DOE Patents [OSTI]

Removable cartridges are used on automated flow-through systems for the purpose of extracting and purifying genetic material from complex matrices. Different types of cartridges are paired with specific automated protocols to concentrate, extract, and purifying pathogenic or human genetic material. Their flow-through nature allows large quantities sample to be processed. Matrices may be filtered using size exclusion and/or affinity filters to concentrate the pathogen of interest. Lysed material is ultimately passed through a filter to remove the insoluble material before the soluble genetic material is delivered past a silica-like membrane that binds the genetic material, where it is washed, dried, and eluted. Cartridges are inserted into the housing areas of flow-through automated instruments, which are equipped with sensors to ensure proper placement and usage of the cartridges. Properly inserted cartridges create fluid- and air-tight seals with the flow lines of an automated instrument.

Regan, John Frederick

2014-09-09T23:59:59.000Z

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Research and development of a phosphoric acid fuel cell/battery power source integrated in a test-bed bus. Final report  

SciTech Connect (OSTI)

This project, the research and development of a phosphoric acid fuel cell/battery power source integrated into test-bed buses, began as a multi-phase U.S. Department of Energy (DOE) project in 1989. Phase I had a goal of developing two competing half-scale (25 kW) brassboard phosphoric acid fuel cell systems. An air-cooled and a liquid-cooled fuel cell system were developed and tested to verify the concept of using a fuel cell and a battery in a hybrid configuration wherein the fuel cell supplies the average power required for operating the vehicle and a battery supplies the `surge` or excess power required for acceleration and hill-climbing. Work done in Phase I determined that the liquid-cooled system offered higher efficiency.

NONE

1996-05-30T23:59:59.000Z

182

Use of plant fatty acyl hydroxylases to produce hydroxylated fatty acids and derivatives in plants  

DOE Patents [OSTI]

The present invention relates to the identification of nucleic acid sequences and constructs, and methods related thereto, and the use of these sequences and constructs to produce genetically modified plants for the purpose of altering the composition of plant oils, waxes and related compounds.

Somerville, Chris (Portola Valley, CA); van de Loo, Frank (Lexington, KY)

2002-01-01T23:59:59.000Z

183

Research, development, and demonstration of lead-acid batteries for electric-vehicle propulsion. Annual report, 1980  

SciTech Connect (OSTI)

The first development effort in improving lead-acid batteries fore electric vehicles was the improvement of electric vehicle batteries using flat pasted positive plates and the second was for a tubular long life positive plate. The investigation of 32 component variables based on a flat pasted positive plate configuration is described. The experiment tested 96 - six volt batteries for characterization at 0, 25, and 40/sup 0/C and for cycle life capability at the 3 hour discharge rate with a one cycle, to 80% DOD, per day regime. Four positive paste formulations were selected. Two commercially available microporous separators were used in conjunction with a layer of 0.076 mm thick glass mat. Two concentrations of battery grade sulfuric acid were included in the test to determine if an increase in concentration would improve the battery capacity sufficient to offset the added weight of the more concentrated solution. Two construction variations, 23 plate elements with outside negative plates and 23 plate elements with outside positive plates, were included. The second development effort was an experiment designed to study the relationship of 32 component variables based on a tubular positive plate configuration. 96-six volt batteries were tested at various discharge rates at 0, 25, and 40/sup 0/C along with cycle life testing at 80% DOD of the 3 hour rate. 75 batteries remain on cycle life testing with 17 batteries having in excess of 365 life cycles. Preliminary conclusions indicate: the tubular positive plate is far more capable of withstanding deep cycles than is the flat pasted plate; as presently designed 40 Whr/kg can not be achieved, since 37.7 Whr/kg was the best tubular data obtained; electrolyte circulation is impaired due to the tight element fit in the container; and a redesign is required to reduce the battery weight which will improve the Whr/kg value. This redesign is complete and new molds have been ordered.

Not Available

1981-03-01T23:59:59.000Z

184

Research  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassive Solar HomePromisingStories » RemovingResearch CORE-SHELL NANOPARTICLES AND

185

acid docosahexaenoic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 38 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

186

acid aspartic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 20 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

187

acid caffeic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 11 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

188

acid benzoic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 24 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

189

acid propanoic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 9 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

190

acid oleic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 31 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

191

Methods and compounds for chemical ligation  

DOE Patents [OSTI]

Compositions and methods for chemical ligation are provided. Methods for nucleic acid sequencing, nucleic acid assembly and nucleic acid synthesis are also provided.

Church, George M.; Sismour, A. Michael

2013-07-09T23:59:59.000Z

192

Strategies for enhancing the effectiveness of metagenomic-based enzyme discovery in lignocellulytic microbial communities  

E-Print Network [OSTI]

for genome annotation: PRIAM. Nucleic Acids Research 31:November 2008 release of PRIAM [12], modified for nucleotide232,025) at EPRIAM enzyme-specific sequence profiles

DeAngelis, K.M.

2010-01-01T23:59:59.000Z

193

Using IMG: Comparative Analysis with the Integrated Microbial Genomes System  

E-Print Network [OSTI]

for genome annotation: PRIAM. Nucleic Acids Research 31 (RPS-BLAST against the PRIAM database (12), as a complementBLAST computations. Computation COG PRIAM Tool Low- Maximum

2008-01-01T23:59:59.000Z

194

HexServer: an FFT-based protein docking server powered by graphics processors  

E-Print Network [OSTI]

MACINDOE,G. MAVRIDIS,L. VENKATRAMAN,V. DEVIGNES,M. RITCHIE,D.W. Nucleic Acids Research Oxford University Press

MACINDOE, G.; MAVRIDIS, L.; VENKATRAMAN, V.; DEVIGNES, M.; RITCHIE, D.W.; Nucleic Acids Research Oxford University Press [More Details

195

The influence of naturally-occurring organic acids on model estimates of lakewater acidification using the model of acidification of groundwater in catchments (MAGIC). Summary of research conducted during year 1  

SciTech Connect (OSTI)

A project for the US Department of Energy, entitled ``Incorporation of an organic acid representation into MAGIC (Model of Acidification of Groundwater in Catchments) and Testing of the Revised Model UsingIndependent Data Sources`` was initiated by E&S Environmental Chemistry, Inc. in March, 1992. Major components of the project include: improving the MAGIC model by incorporating a rigorous organic acid representation, based on empirical data and geochemical considerations, and testing the revised model using data from paleolimnological hindcasts of preindustrial chemistry for 33 Adirondack Mountain lakes, and the results of whole-catchment artificial acidification projects in Maine and Norway. The ongoing research in this project involves development of an organic acid representation to be incorporated into the MAGIC modeland testing of the improved model using three independent data sources. The research during Year 1 has included conducting two workshops to agree on an approach for the organic acid modeling, developing the organic subroutine and incorporating it into MAGIC (Task 1), conducing MAGIC hindcasts for Adirondack lakes and comparing the results with paleolimnological reconstructions (Task 2), and conducting site visits to the manipulation project sites in Maine and Norway. The purpose of this report is to provide a summary of the work that has been conducted on this project during Year 1. Tasks 1 and 2 have now been completed.

Sullivan, T.J.; Eilers, J.M. [E and S Environmental Chemistry, Inc., Corvallis, OR (United States)] [E and S Environmental Chemistry, Inc., Corvallis, OR (United States); Cosby, B.J. [Virginia Univ., Charlottesville, VA (United States). Dept. of Environmental Sciences] [Virginia Univ., Charlottesville, VA (United States). Dept. of Environmental Sciences; Driscoll, C.T. [Syracuse Univ., NY (United States). Dept. of Civil Engineering] [Syracuse Univ., NY (United States). Dept. of Civil Engineering; Hemond, H.F. [Massachusetts Inst. of Tech., Cambridge, MA (United States). Dept. of Civil Engineering] [Massachusetts Inst. of Tech., Cambridge, MA (United States). Dept. of Civil Engineering; Charles, D.F. [Academy of Natural Sciences of Philadelphia, PA (United States). Patrick Center for Environmental Research] [Academy of Natural Sciences of Philadelphia, PA (United States). Patrick Center for Environmental Research; Norton, S.A. [Maine Univ., Orono, ME (United States). Dept. of Geological Sciences] [Maine Univ., Orono, ME (United States). Dept. of Geological Sciences

1993-03-05T23:59:59.000Z

196

The Effect of Dye-Dye Interactions on the Spatial Resolution of Single-Molecule FRET Measurements in Nucleic Acids  

E-Print Network [OSTI]

The Effect of Dye-Dye Interactions on the Spatial Resolution of Single-Molecule FRET Measurements Engineering, Boston University, Boston, Massachusetts ABSTRACT We study the effect of dye-dye interactions-nm separation, provided that dye-dye quenching is accounted for. At these short separations, we find

197

Electronic structure and spectroscopy of nucleic acid bases: Ionization energies, ionization-induced structural changes, and photoelectron spectra  

SciTech Connect (OSTI)

We report high-level ab initio calculations and single-photon ionization mass spectrometry study of ionization of adenine (A), thymine (T), cytosine (C) and guanine (G). For thymine and adenine, only the lowest-energy tautomers were considered, whereas for cytosine and guanine we characterized five lowest-energy tautomeric forms. The first adiabatic and several vertical ionization energies were computed using equation-of-motion coupled-cluster method for ionization potentials with single and double substitutions. Equilibrium structures of the cationic ground states were characterized by DFT with the {omega}B97X-D functional. The ionization-induced geometry changes of the bases are consistent with the shapes of the corresponding molecular orbitals. For the lowest-energy tautomers, the magnitude of the structural relaxation decreases in the following series G > C > A > T, the respective relaxation energies being 0.41, 0.32, 0.25 and 0.20 eV. The computed adiabatic ionization energies (8.13, 8.89, 8.51-8.67 and 7.75-7.87 eV for A,T,C and G, respectively) agree well with the onsets of the photoionization efficiency (PIE) curves (8.20 {+-} 0.05, 8.95 {+-} 0.05, 8.60 {+-} 0.05 and 7.75 {+-} 0.05 eV). Vibrational progressions for the S{sub 0}-D{sub 0} vibronic bands computed within double-harmonic approximation with Duschinsky rotations are compared with previously reported experimental photoelectron spectra.

Bravaya, Ksenia B.; Kostko, Oleg; Dolgikh, Stanislav; Landau, Arie; Ahmed, Musahid; Krylov, Anna I.

2010-08-02T23:59:59.000Z

198

Thermodynamics and Enzymatic Polymerization of Artificial Metallo-Nucleic Acids AND Investigation of Duplex Formation between GAN and RNA  

E-Print Network [OSTI]

°C rt (92%). (c) DMTrCl, pyridine, rt (69%). (d) (iPr) 2 NP(Cl)OEtCN, (iPr) 2 NEt, CH 2 Cl 2 , rt (71%). Scheme 1. 7N,N-diisopropylehylamine ((iPr) 2 NEt) and 2-cyanoehtyl-N,N-

Kim, Eun Kyong

2011-01-01T23:59:59.000Z

199

Discrimination of Alternative Spliced Isoforms by Real-Time PCR Using Locked Nucleic Acid (LNA) Substituted Primer  

E-Print Network [OSTI]

Determination of quantitative expression levels of alternatively spliced isoforms provides an important approach to the understanding of the functional significance of each isoform. Real-time PCR using exon junction ...

Wan, Guoqiang

200

Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same  

DOE Patents [OSTI]

The invention provides an array of oligonucleotide probes immobilized on a solid support for analysis of a target sequence from a human immunodeficiency virus. The array comprises at least four sets of oligonucleotide probes 9 to 21 nucleotides in length. A first probe set has a probe corresponding to each nucleotide in a reference sequence from a human immunodeficiency virus. A probe is related to its corresponding nucleotide by being exactly complementary to a subsequence of the reference sequence that includes the corresponding nucleotide. Thus, each probe has a position, designated an interrogation position, that is occupied by a complementary nucleotide to the corresponding nucleotide. The three additional probe sets each have a corresponding probe for each probe in the first probe set. Thus, for each nucleotide in the reference sequence, there are four corresponding probes, one from each of the probe sets. The three corresponding probes in the three additional probe sets are identical to the corresponding probe from the first probe or a subsequence thereof that includes the interrogation position, except that the interrogation position is occupied by a different nucleotide in each of the four corresponding probes.

Chee, Mark (Palo Alto, CA); Gingeras, Thomas R. (Santa Clara, CA); Fodor, Stephen P. A. (Palo Alto, CA); Hubble, Earl A. (Mountain View, CA); Morris, MacDonald S. (San Jose, CA)

1999-01-19T23:59:59.000Z

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Activation of nucleic acid-sensing Toll-like receptors requires cleavage by endolysosomal proteases: a mechanism to avoid autoimmunity  

E-Print Network [OSTI]

receptor DC: dendritic cell pDC: plasmacytoid dendritic celltaken up by plasmacytoid DCs (pDC) and elicit large amountsare also components of the pDC-MyD88 signaling complex (

Ewald, Sarah Elisabeth

2010-01-01T23:59:59.000Z

202

Thermodynamics and Enzymatic Polymerization of Artificial Metallo-Nucleic Acids AND Investigation of Duplex Formation between GAN and RNA  

E-Print Network [OSTI]

cells on a Varian Cary 500 UV-Vis spectrophotometer equipped with a Peltiercell on a Varian Cary 500 UV-Vis spectrophotometer equipped with a Peltier

Kim, Eun Kyong

2011-01-01T23:59:59.000Z

203

Electrical Detection of Nucleic Acid Amplification Using an On-Chip Quasi-Reference Electrode and a PVC REFET  

E-Print Network [OSTI]

and a PVC REFET Eric Salm,, Yu Zhong,,§ Bobby Reddy, Jr.,,§ Carlos Duarte-Guevara,,§ Vikhram Swaminathan that utilizes a platinum QRE to establish a pH-sensitive fluid gate potential and a PVC membrane REFET to enable

Bashir, Rashid

204

acidization: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 7 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

205

Impact of Herbicides on Winter Canola (Brassica napus L.) Production and Fatty Acid Composition in South Texas  

E-Print Network [OSTI]

by the herbicides evaluated. Fatty acid composition, specifically stearic acid, oleic acid, linolenic acid, and oleic to linolenic acid ratio, was affected by herbicide treatments. This research found that protoporphyrinogen oxidase (PPG oxidase) inhibitor...

Cogdill, Todd Joseph

2013-01-16T23:59:59.000Z

206

Experimental Investigation for the Effects of the Core Geometry on the Optimum Acid Flux in Carbonate Acidizing  

E-Print Network [OSTI]

Previous matrix acidizing experimental research showed that there exists an optimum acid interstitial velocity (Vi-opt) that results in the minimum volume of acid used while providing the best stimulation results. There are already several...

Jin, Xiao

2013-11-21T23:59:59.000Z

207

(Acid rain workshop)  

SciTech Connect (OSTI)

The traveler presented a paper entitled Susceptibility of Asian Ecosystems to Soil-Mediated Acid Rain Damage'' at the Second Workshop on Acid Rain in Asia. The workshop was organized by the Asian Institute of Technology (Bangkok, Thailand), Argonne National Laboratory (Argonne, Illinois), and Resource Management Associates (Madison, Wisconsin) and was sponsored by the US Department of Energy, the United Nations Environment Program, the United Nations Economic and Social Commission for Asia and the Pacific, and the World Bank. Papers presented on the first day discussed how the experience gained with acid rain in North America and Europe might be applied to the Asian situation. Papers describing energy use projections, sulfur emissions, and effects of acid rain in several Asian countries were presented on the second day. The remaining time was allotted to discussion, planning, and writing plans for a future research program.

Turner, R.S.

1990-12-05T23:59:59.000Z

208

acid-dependent ribonucleic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 40 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

209

Cost Effective Bioethanol via Acid Pretreatment of Corn Stover, Saccharification, and Conversion via a Novel Fermentation Organism: Cooperative Research and Development Final Report, CRADA Number: CRD-12-485  

SciTech Connect (OSTI)

This research program will convert acid pretreated corn stover to sugars at the National Renewable Energy Laboratory (NREL) and then transfer these sugars to Honda R&D and its partner the Green Earth Institute (GEI) for conversion to ethanol via a novel fermentation organism. In phase one, NREL will adapt its pretreatment and saccharification process to the unique attributes of this organism, and Honda R&D/GEI will increase the sugar conversion rate as well as the yield and titer of the resulting ethanol. In later phases, NREL, Honda R&D, and GEI will work together at NREL to optimize and scale-up to pilot-scale the Honda R&D/GEI bioethanol production process. The final stage will be to undertake a pilot-scale test at NREL of the optimized bioethanol conversion process.

Dowe, N.

2014-05-01T23:59:59.000Z

210

Postdoctoral Research Awards Annual Research Meeting: Sarah Hobdey...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

EERE Postdoctoral Research Awards Annual Meeting Posters Process Design and Economics for Biochemical Conversion of Lignocellulosic Biomass to Ethanol: Dilute-Acid...

211

Naphthenic acid corrosion literature survey  

SciTech Connect (OSTI)

Naphthenic acid corrosion is a growing concern for refineries processing crudes containing high levels of naphthenic acid. Due to this concern initiatives in place to better understand the mechanism of corrosion for mitigating the corrosion. During the 1996 Fall Corrosion Group, organized existing literature relevant to the literature search. Committee Week, NACE International many refineries have and evaluate methods T-8 Refining Industry a task group, T-8-22, to perform a review and compilation of naphthenic acid corrosion. This paper provides a summary of the literature research.

Babaian-Kibala, E. [Nalco/Exxon Energy Chemicals, Sugar Land, TX (United States); Nugent, M.J. [Tosco Refining Co., Linden, NJ (United States)

1999-11-01T23:59:59.000Z

212

Investigating acid rain  

SciTech Connect (OSTI)

A report is given of an address by Kathleen Bennett, Assistant Administrator of Air, Noise and Radiation, Environmental Protection Agency which was presented to the US Senate Committee on the Environment and Public Works. Bennet explained that in view of the many unknowns about acid rain, and the possible substantial cost burden of additional controls, EPA is proceeding with its program to investigate this environmental malady over a 10-year period. The three major areas of the research program are (1) transport, transformation, and deposition processes, (2) effects of acid deposition, and (3) assessments and policy studies. Other issues discussed were global transboundary air pollution and Senate amendments addressing long-range transport. (JMT)

Not Available

1981-01-01T23:59:59.000Z

213

acid mononucleotide adenylyltransferase: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 14 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

214

aminoadipic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 7 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

215

aminocaproic acid eaca: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 7 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

216

acid hydrazone dpktch: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 11 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

217

aminolevulinic acid dehydratase: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 18 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

218

aminobutyric acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 36 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

219

aminolevulinic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 12 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

220

acid riboside salvage: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 30 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

anf 4-hydroxyhomocitric acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 15 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

222

acid dioxygenase hpd: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 37 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

223

acid ascorbyl palmitate: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 27 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

224

acid dehydratase alad: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 15 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

225

acetoacetic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 8 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

226

acid lna taqman: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 46 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

227

amygdalic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 8 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

228

acid phosphoribosyltransferase 1-deficient: Topics by E-print...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 19 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

229

adipic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 11 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

230

acid dmsa renography: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 8 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

231

anthranilic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 10 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

232

aminocaproic acids: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 7 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

233

acid glycosaminoglycan mucopolysaccharide: Topics by E-print...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 34 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

234

acidic oligosaccharides paos: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 40 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

235

aminobutyric acids: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 36 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

236

asparaginic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 17 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

237

arsonic acids: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 10 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

238

anthraquinonic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 12 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

239

aristolochic acid nephropathy: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 28 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

240

acetylsalicylic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 11 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

acid decarboxylase hgad65: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 32 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

242

Acid rain information book. Draft final report  

SciTech Connect (OSTI)

Acid rain is one of the most widely publicized environmental issues of the day. The potential consequences of increasingly widespread acid rain demand that this phenomenon be carefully evaluated. Reveiw of the literature shows a rapidly growing body of knowledge, but also reveals major gaps in understanding that need to be narrowed. This document discusses major aspects of the acid rain phenomenon, points out areas of uncertainty, and summarizes current and projected research by responsible government agencies and other concerned organizations.

None

1980-12-01T23:59:59.000Z

243

Prolactin messenger ribonucleic acid concentrations throughout the ovine estrous cycle: Assessment relative to prolactin serum and pituitary amounts  

SciTech Connect (OSTI)

Prolactin (PRL) mRNA concentrations were assessed by nucleic acid hybridization assays in pituitaries of ewes representing the defined stages of the ovine estrous cycle. Concomitantly, pituitary and serum PRL concentrations were measured in these ewes using radioimmunoassays. It was observed that PRL serum, pituitary and mRNA concentrations tended to increase near the time of the gonadotropin preovulatory surge, particularly between 24 hrs before behavioral estrus to 5 hours after estrus. However, the changes in PRL mRNA, serum and pituitary concentrations were shown not to be statistically significant. These data suggest that PRL production during the sheep estrous cycle is maintained without dramatic changes in synthesis or secretion.

Landefeld, T.; Roulia, V.; Bagnell, T.; Ballard, T.; Levitan, I. (Univ. of Michigan, Ann Arbor (USA))

1991-01-01T23:59:59.000Z

244

E-Print Network 3.0 - acide nitrique concentre Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Engineering, Metabolic & Biomolecular Engineering National Research Laboratory Collection: Engineering ; Biotechnology 83 A ACID RAIN Audrey Gibson Summary: source of...

245

MATERIALS AND MOLECULAR RESEARCH DIVISION ANNUAL REPORT 1979  

E-Print Network [OSTI]

More than a decade of hydrogen-air fuel cell research andand Hydrogen Utilization in an Acid Fuel Cell," Electrochem.

Authors, Various

2013-01-01T23:59:59.000Z

246

A New Heat Shock Protein That Binds Nucleic Acids* (Received for publication, August 20, 1998, and in revised form, September 28, 1998)  

E-Print Network [OSTI]

production of a number of proteins termed heat shock proteins (Hsps).1 Although heat shock pro- teins were Hsp15-P2 (5 - TCTTGCAGGATCCAGTTATTCACT-3 ), and Taq polymerase (Strat- agene). The PCR product g, 4 °C). All further steps were performed at 4 °C. The cell pellet was resuspended in cold buffer

Bardwell, James

247

Formation and Genotoxicity of Novel Oxidatively Generated Tandem DNA Lesions and N2-(1-carboxyethyl)-2'-deoxyguanosine  

E-Print Network [OSTI]

Nucleic Acids Res. 33, 1593-1603. von Sonntag, C. (1987) TheNucleic Acids Res. 33, 1593-1603. Liu, Z. J. , Gao, Y. , andNucleic Acids Res. 33, 1593-1603. Wang, Y. (2008) Bulky DNA

Jiang, Yong

2009-01-01T23:59:59.000Z

248

2013 METALS IN BIOLOGY GORDON RESEARCH CONFERENCE, JANUARY 20-25, 2013  

SciTech Connect (OSTI)

Typical topics for lectures and posters include: biochemical and biophysical characterization of new metal containing proteins, enzymes, nucleic acids, factors, and chelators from all forms of life; synthesis, detailed characterization, and reaction chemistry of biomimetic compounds; novel crystal and solution structures of biological molecules and synthetic metal-chelates; discussions of the roles that metals play in medicine, maintenance of the environment, and biogeochemical processes; metal homeostasis; application of theory and computations to the structure and mechanism of metal-containing biological systems; and novel applications of spectroscopy to metals in biological systems.

Rosenzweig, Amy

2013-01-25T23:59:59.000Z

249

Sequence Logos: A New Way to Display Consensus Sequences  

E-Print Network [OSTI]

, P. O. Box B, Frederick, MD 21701. Internet addresses: toms@ncifcrf.gov and stephens@ncifcrf.gov. y. Michael Stephens \\Lambda version = 1.55 of logopaper.tex 1999 August 5 Nucleic Acids Research, 18: 6097

Schneider, Thomas D.

250

Sequence Logos: A New Way to Display Consensus Sequences  

E-Print Network [OSTI]

. Internet addresses: toms@ncifcrf.gov and stephens@ncifcrf.gov. ycorresponding author 1 #12;2. The order Stephens version = 1.55 of logopaper.tex 1999 August 5 Nucleic Acids Research, 18: 6097-6100 (1990

Schneider, Thomas D.

251

E-Print Network 3.0 - assisted binding site Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Press 4994--5002 Nucleic Acids Research, 1997, Vol. 25, No. 24 Summary: analysis of Fis binding sites Paul N. Hengen 1 , Stacy L. Bartram 1,2,+ , Lisa E. Stewart 1 and Thomas...

252

E-Print Network 3.0 - ans preferred site Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Press 4994--5002 Nucleic Acids Research, 1997, Vol. 25, No. 24 Summary: analysis of Fis binding sites Paul N. Hengen 1 , Stacy L. Bartram 1,2,+ , Lisa E. Stewart 1 and Thomas...

253

Acid deposition in Maryland: Summary of results through 1989. Final report  

SciTech Connect (OSTI)

The Chesapeake Bay Research and Monitoring Program coordinates Maryland's acid deposition research and reports research results annually. The report evaluates several major topic areas including transport and chemistry of acid deposition, its potential impacts on the State's streams and fish, possible impacts on terrestrial resources such as crops and forests and on materials, the ability of energy conservation programs to reduce emissions of acid-forming pollutants, and mitigation techniques for neutralizing acid waters.

DeMuro, J.; Bowman, M.; Maxwell, C.; Asante-Duah, D.; Meyers, S.

1990-06-01T23:59:59.000Z

254

RegPredict: an integrated system for regulon inference in prokaryotes by comparative genomics approach  

E-Print Network [OSTI]

motifs by comparative genomics. Nucleic Acids Res. , 28,M.S. (2009) Comparative genomics of regulation of fatty acidcomparative and functional genomics. Nucleic Acids Res. ,

Novichkov, Pavel S.

2010-01-01T23:59:59.000Z

255

Plant fatty acid hydroxylases  

DOE Patents [OSTI]

This invention relates to plant fatty acyl hydroxylases. Methods to use conserved amino acid or nucleotide sequences to obtain plant fatty acyl hydroxylases are described. Also described is the use of cDNA clones encoding a plant hydroxylase to produce a family of hydroxylated fatty acids in transgenic plants. In addition, the use of genes encoding fatty acid hydroxylases or desaturases to alter the level of lipid fatty acid unsaturation in transgenic plants is described.

Somerville, Chris (Portola Valley, CA); Broun, Pierre (Burlingame, CA); van de Loo, Frank (Lexington, KY)

2001-01-01T23:59:59.000Z

256

ATMOSPHERIC ~ ~ RESEARCH  

E-Print Network [OSTI]

. 1. Introduction Air pollution and acid rain have become the subject of (not only) scientific within the troposphere and the transport of pollutants as well as acid rain even in rural regions

Moelders, Nicole

257

Production of Succinic Acid for Lignocellulosic Hydrolysates  

SciTech Connect (OSTI)

The purpose of this Cooperative Research and Development Agreement (CRADA) is to add and test new metabolic activities to existing microbial catalysts for the production of succinic acid from renewables. In particular, they seek to add to the existing organism the ability to utilize xylose efficiently and simultaneously with glucose in mixtures of sugars or to add succinic acid production to another strain and to test the value of this new capability for production of succinic acid from industrial lignocellulosic hydrolyasates. The Contractors and Participant are hereinafter jointly referred to as the 'Parties'. Research to date in succinic acid fermentation, separation and genetic engineering has resulted in a potentially economical process based on the use of an Escherichia coli strain AFP111 with suitable characteristics for the production of succinic acid from glucose. Economic analysis has shown that higher value commodity chemicals can be economically produced from succinic acid based on repliminary laboratory findings and predicted catalytic parameters. The initial target markets include succinic acid itself, succinate salts, esters and other derivatives for use as deicers, solvents and acidulants. The other commodity products from the succinic acid platform include 1,4-butanediol, {gamma}-butyrolactone, 2-pyrrolidinone and N-methyl pyrrolidinone. Current economic analyses indicate that this platform is competitive with existing petrochemical routes, especially for the succinic acid and derivatives. The report presents the planned CRADA objectives followed by the results. The results section has a combined biocatalysis and fermentation section and a commercialization section. This is a nonproprietary report; additional proprietary information may be made available subject to acceptance of the appropriate proprietary information agreements.

Davison, B.H.; Nghiem, J.

2002-06-01T23:59:59.000Z

258

Correction to "Sulfuric acid deposition from stratospheric geoengineering with sulfate aerosols"  

E-Print Network [OSTI]

Correction to "Sulfuric acid deposition from stratospheric geoengineering with sulfate aerosols (2010), Correction to "Sulfuric acid deposition from stratospheric geoengineering with sulfate aerosols from stratospheric geoengineering with sulfate aerosols" (Journal of Geophysical Research, 114, D14109

Robock, Alan

259

Effect of droplet size on the behavior and characteristics of emulsified acid  

E-Print Network [OSTI]

Emulsified acids have been extensively used in the oil industry since 1933. Most of the available research and publications discussed mainly the application of emulsified acid in the field. A fair number of the published work also discussed in depth...

Almutairi, Saleh Haif

2008-10-10T23:59:59.000Z

260

acidic pathogenesis-related pr-1: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 23 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

acid o-methyltransferase activity1: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 39 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

262

alpha-oxo acid decarboxylase: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 32 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

263

anti-psoriatic fumaric acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 15 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

264

alpha2-6-linked sialic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 33 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

265

anti-proliferative acidic meglcua: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 12 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

266

abscisic acid receptor1oa: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by USDA and U of I researchers Illinois at Urbana-Champaign, University of 44 Controlling acid rain MIT - DSpace Summary: High concentrations of sulfuric and nitric acid in raTn fn...

267

E-Print Network 3.0 - acid-g-ethylene glycol prepared Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of interest in this research were com- plexing poly(methacrylic acid-g-ethylene glycol) hydro- gels... Part Synthesis of Poly(methacrylic acid-g-ethylene glycol) ... Source:...

268

Process for the preparation of lactic acid and glyceric acid  

DOE Patents [OSTI]

Hexose and pentose monosaccharides are degraded to lactic acid and glyceric acid in an aqueous solution in the presence of an excess of a strongly anionic exchange resin, such as AMBERLITE IRN78 and AMBERLITE IRA400. The glyceric acid and lactic acid can be separated from the aqueous solution. Lactic acid and glyceric acid are staple articles of commerce.

Jackson, James E [Haslett, MI; Miller, Dennis J [Okemos, MI; Marincean, Simona [Dewitt, MI

2008-12-02T23:59:59.000Z

269

STANDARD OPERATING PROCEDURE ACIDS CONTAINING PHOSPHOROUS  

E-Print Network [OSTI]

12.1 STANDARD OPERATING PROCEDURE for ACIDS CONTAINING PHOSPHOROUS Location(s): ___________________________________________________ Chemical(s): Hypophosphorous acid, methylphosphonic acid, phosphonic acid, phosphoric acid, phosphorous

Pawlowski, Wojtek

270

Microorganisms for producing organic acids  

DOE Patents [OSTI]

Organic acid-producing microorganisms and methods of using same. The organic acid-producing microorganisms comprise modifications that reduce or ablate AcsA activity or AcsA homolog activity. The modifications increase tolerance of the microorganisms to such organic acids as 3-hydroxypropionic acid, acrylic acid, propionic acid, lactic acid, and others. Further modifications to the microorganisms increase production of such organic acids as 3-hydroxypropionic acid, lactate, and others. Methods of producing such organic acids as 3-hydroxypropionic acid, lactate, and others with the modified microorganisms are provided. Methods of using acsA or homologs thereof as counter-selectable markers are also provided.

Pfleger, Brian Frederick; Begemann, Matthew Brett

2014-09-30T23:59:59.000Z

271

Electrostatic precipitation of condensed acid mist  

SciTech Connect (OSTI)

Southern Research Institute is developing a compact, wet electrostatic precipitator (WESP) to control acid mist missions from high-sulfur coal combustion. The WESP is being developed as a retrofit technology for existing coal-fired power plants, particularly those equipped with wet flue gas desulfurization (FGD) scrubbers. Acid mist emissions can be a significant problem at these facilities because the sulfuric acid vapor in the flue gas is converted to a very fine mist that is not collected in the scrubber system. Conventional mist eliminators are not adequate in this application due to the very fine size of the mist droplets. The potential for corrosion also makes it difficult to use a fabric filter or a conventional, dry ESP in this application. Therefore, this research project has been structured around the development of a compact WESP that could be retrofit on top of an existing scrubber or within an existing flue gas duct. This paper describes the development and testing of a prototype WESP for the utility acid mist application. Testing was conducted with combustion of sulfur-doped gas to simulate the acid mist alone, and with a combination of coal and sulfur-doped gas to simulate the mixture of acid mist and fly ash downstream from a scrubber. The performance of the WESP test unit was modeled using two different cylindrical-geometry computer models: a current-seeking'' model and a current-specific'' model. 8 refs., 15 figs., 7 tabs.

Dahlin, R.S.

1989-11-01T23:59:59.000Z

272

Separation Nanotechnology of Diethylenetriaminepentaacetic Acid...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Nanotechnology of Diethylenetriaminepentaacetic Acid Bonded Magnetic Nanoparticles for Spent Nuclear Fuel. Separation Nanotechnology of Diethylenetriaminepentaacetic Acid Bonded...

273

Exploring the associations of maternal red blood cell fatty acids, infant body composition, and quality of infant growth  

E-Print Network [OSTI]

(21:0) and infant FM (r = 0.23, p = 0.049). Vaccenic acid (18:1n-7t) showed an association that approached significance (presented in italics in Table 3). Table 3. Correlation Matrix of Significant Fatty Acids for Visit 1 Fatty Acid (%) Percentage... expression (12). Research currently has studied associations between essential fatty acids such as the omega-3 (n-3) fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), and omega-6 (n-6) fatty acid arachidonic acid (AA) in maternal...

Newbold, Emily A.

2014-05-31T23:59:59.000Z

274

Reactive Distillation for Esterification of Bio-based Organic Acids  

SciTech Connect (OSTI)

The following is the final report of the three year research program to convert organic acids to their ethyl esters using reactive distillation. This report details the complete technical activities of research completed at Michigan State University for the period of October 1, 2003 to September 30, 2006, covering both reactive distillation research and development and the underlying thermodynamic and kinetic data required for successful and rigorous design of reactive distillation esterification processes. Specifically, this project has led to the development of economical, technically viable processes for ethyl lactate, triethyl citrate and diethyl succinate production, and on a larger scale has added to the overall body of knowledge on applying fermentation based organic acids as platform chemicals in the emerging biorefinery. Organic acid esters constitute an attractive class of biorenewable chemicals that are made from corn or other renewable biomass carbohydrate feedstocks and replace analogous petroleum-based compounds, thus lessening U.S. dependence on foreign petroleum and enhancing overall biorefinery viability through production of value-added chemicals in parallel with biofuels production. Further, many of these ester products are candidates for fuel (particularly biodiesel) components, and thus will serve dual roles as both industrial chemicals and fuel enhancers in the emerging bioeconomy. The technical report from MSU is organized around the ethyl esters of four important biorenewables-based acids: lactic acid, citric acid, succinic acid, and propionic acid. Literature background on esterification and reactive distillation has been provided in Section One. Work on lactic acid is covered in Sections Two through Five, citric acid esterification in Sections Six and Seven, succinic acid in Section Eight, and propionic acid in Section Nine. Section Ten covers modeling of ester and organic acid vapor pressure properties using the SPEAD (Step Potential Equilibrium and Dynamics) method.

Fields, Nathan; Miller, Dennis J.; Asthana, Navinchandra S.; Kolah, Aspi K.; Vu, Dung; Lira, Carl T.

2008-09-23T23:59:59.000Z

275

Laboratory Directed Research and Development Program: Annual report to the Department of Energy  

SciTech Connect (OSTI)

Project program summaries are presented for: effect of bacterial spore protein on mutagenesis; cellular toxicity of coaine and cocaethylene; calcinfication in marine alga (global carbon cycling); advanced permanent magnet materials; a high flux neutron source; genetics of drug addiction; microdialysis; analysis of powder diffraction data; accelerator technology; nucleic acids and proteins and their interactions, by small-angle XRD; enhancement of microplanar beam radiation therapy of gliosarcoma; relaxographic and functional MRI; low-temperature infrared laser absorption spectroscopy; photodesorption of H{sub 2}; helical magnet for RHIC; novel microporous solids; chemistry and physics of stratospheric aerosols (ozone depletion); rf source for linear colliders; resonance Raman detection of VOCs; synthesis of plant fatty acids with unusual double bond positions; outer surface proteins of the Lyme disease spirochete; multiwire proportional chambers for collider muons; self-organized criticality; PCR-SSCP detection of genetic changes at single cell level; proton facility for cancer therapy; and visible free-electron laser experiment.

Ogeka, G.J.; Romano, A.J.

1994-12-01T23:59:59.000Z

276

Reversible Acid Gas Capture  

ScienceCinema (OSTI)

Pacific Northwest National Laboratory scientist David Heldebrant demonstrates how a new process called reversible acid gas capture works to pull carbon dioxide out of power plant emissions.

Dave Heldebrant

2012-12-31T23:59:59.000Z

277

EMSL - Nuclei acid structure  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

conditions showed a temporary pH decrease, with a concomitant increase in formic acid during exponential growth. Fermentation experiments performed outside of the magnet...

278

Nuclei acid structure | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

conditions showed a temporary pH decrease, with a concomitant increase in formic acid during exponential growth. Fermentation experiments performed outside of the magnet...

279

Investigating fatty acid biosynthesis within the algal chloroplast using Chlamydomonas reinhardtii as a model  

E-Print Network [OSTI]

offering a continuous algal production-secretion system thatalgal lipids [124]. As such, there are many research groups interested in engineering fatty acid production and secretion

Blatti, Jillian L.

2012-01-01T23:59:59.000Z

280

E-Print Network 3.0 - acid deposition forest Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

upland areas (occult deposition). The acid pollutants may also... through to the soil by rainwater. ... Source: Forest Research Agency of the UK Forestry Commission Collection:...

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

E-Print Network 3.0 - acid gas emissions Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

control is the per formance of the acid gas... can control emissions of priority pollutants, including ... Source: Columbia University - Waste-to-Energy Research and Technology...

282

E-Print Network 3.0 - acid aptamer libraries Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Search Sample search results for: acid aptamer libraries Page: << < 1 2 3 4 5 > >> 1 Chemistry Department 2011 Summer Research Program Summary: that within a large library of...

283

Controlling acid rain  

E-Print Network [OSTI]

High concentrations of sulfuric and nitric acid in raTn fn the northeastern USA are caused by the large scale combustion of fossil fuels within this region. Average precipitation acidity is pH 4.2, but spatial and temporal ...

Fay, James A.

1983-01-01T23:59:59.000Z

284

Research Statement  

E-Print Network [OSTI]

entries in the natural numbers, into an undergraduate research project. ..... and developing the undergraduate research project described at the end of Section 2,

2015-01-18T23:59:59.000Z

285

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Madden-Julian Oscillation Heating: to Tilt or Not to Tilt For original submission and image(s), see ARM Research Highlights http:www.arm.govsciencehighlights Research...

286

Research Library  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

LANL Research Library: delivering essential knowledge services for national security sciences since 1947 About the Research Library The Basics Mission We deliver agile, responsive...

287

IMPROVED PROCESSES TO REMOVE NAPHTHENIC ACIDS  

SciTech Connect (OSTI)

In the first year of this project, we have established our experimental and theoretical methodologies for studies of the catalytic decarboxylation process. We have developed both glass and stainless steel micro batch type reactors for the fast screening of various catalysts with reaction substrates of model carboxylic acid compounds and crude oil samples. We also developed novel product analysis methods such as GC analyses for organic acids and gaseous products; and TAN measurements for crude oil. Our research revealed the effectiveness of several solid catalysts such as NA-Cat-1 and NA-Cat-2 for the catalytic decarboxylation of model compounds; and NA-Cat-5{approx}NA-Cat-9 for the acid removal from crude oil. Our theoretical calculations propose a three-step concerted oxidative decarboxylation mechanism for the NA-Cat-1 catalyst.

Aihua Zhang; Qisheng Ma; William A. Goddard; Yongchun Tang

2004-04-28T23:59:59.000Z

288

Fatty Acid Carcass Mapping  

E-Print Network [OSTI]

FATTY ACID CARCASS MAPPING A Thesis by STACEY NICOLE TURK Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE May 2008... Major Subject: Animal Science FATTY ACID CARCASS MAPPING A Thesis by STACEY NICOLE TURK Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE...

Turk, Stacey N.

2010-01-14T23:59:59.000Z

289

The utilization of tricarboxylic acid cycle acids and the uptake of succinic acid by Neurospora crassa  

E-Print Network [OSTI]

THE UTILIZATION OF TRICARBOXYLIC ACID CYCLE ACIDS AND THE UPTAKE OF SUCCINIC ACID BY NEUROSPORA CRASSA A Thesis by PATTI LYNN GILLILAND Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement... for the degree of MASTER OF SCIENCE August 1978 Ma) or Subject: Microbiology THE UTILIZATION OF TRICARBOXYLIC ACID CYCLE ACIDS AND THE UPTAKE OF SUCCINIC ACID BY NEUROSPORA CRASSA A Thesis by PATTI LYNN GILLILAND Approved as to style and content by...

Gilliland, Patti Lynn

2012-06-07T23:59:59.000Z

290

GE, University of Washington Disease Detection | GE Global Research  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

excited about this team's unique ability to combine new designs for paper-based microfluidics with new nucleic amplification methods and GE's novel paper chemistries to help...

291

Focus Sheet | Hydrofluoric Acid Health hazards of hydrofluoric acid  

E-Print Network [OSTI]

Focus Sheet | Hydrofluoric Acid Health hazards of hydrofluoric acid Hydrofluoric acid (HF characterized by weight loss, brittle bones, anemia, and general ill health. Safe use If possible, avoid working to exposures. #12;Focus Sheet | Hydrofluoric Acid Environmental Health and Safety Environmental Programs Office

Wilcock, William

292

Optical high acidity sensor  

DOE Patents [OSTI]

An apparatus and method for determining acid concentrations in solutions having acid concentrations of from about 0.1 Molar to about 16 Molar is disclosed. The apparatus includes a chamber for interrogation of the sample solution, a fiber optic light source for passing light transversely through the chamber, a fiber optic collector for receiving the collimated light after transmission through the chamber, a coating of an acid resistant polymeric composition upon at least one fiber end or lens, the polymeric composition in contact with the sample solution within the chamber and having a detectable response to acid concentrations within the range of from about 0.1 Molar to about 16 Molar, a measurer for the response of the polymeric composition in contact with the sample solution, and, a comparer of the measured response to predetermined standards whereby the acid molarity of the sample solution within the chamber can be determined. Preferably, a first lens is attached to the end of the fiber optic light source, the first lens adapted to collimate light from the fiber optic light source, and a second lens is attached to the end of the fiber optic collector for focusing the collimated light after transmission through the chamber.

Jorgensen, Betty S. (Jemez Springs, NM); Nekimken, Howard L. (Los Alamos, NM); Carey, W. Patrick (Lynnwood, WA); O'Rourke, Patrick E. (Martinez, GA)

1997-01-01T23:59:59.000Z

293

A Novel Model for Fracture Acidizing with Important Thermal Effects  

E-Print Network [OSTI]

A NOVEL MODEL FOR FRACTURE ACIDIZING WITH IMPORTANT THERMAL EFFECTS A Thesis by JOHN BRENDAN LYONS Submitted to the Office of Graduate and Professional Studies of Texas A&M University in partial fulfillment of the requirements for the degree... benefit to my research. I would like to acknowledge the Qatar National Research Fund, NPRP 09-828-2-316, for supporting this research. The facilities and resources provided by the Harold Vance Department of Petroleum Engineering of Texas A&M University...

Lyons, John

2013-12-05T23:59:59.000Z

294

A Direct, Biomass-Based Synthesis of Benzoic Acid: Formic Acid-Mediated Deoxygenation of the Glucose-Derived Materials Quinic Acid and Shikimic Acid  

SciTech Connect (OSTI)

An alternative biomass-based route to benzoic acid from the renewable starting materials quinic acid and shikimic acid is described. Benzoic acid is obtained selectively using a highly efficient, one-step formic acid-mediated deoxygenation method.

Arceo, Elena; Ellman, Jonathan; Bergman, Robert

2010-05-03T23:59:59.000Z

295

Synthesis of acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters  

DOE Patents [OSTI]

A process of preparing an acid addition salt of delta-aminolevulinc acid comprising: a) dissolving a lower alkyl 5-bromolevulinate and hexamethylenetetramine in a solvent selected from the group consisting of water, ethyl acetate, chloroform, acetone, ethanol, tetrahydrofuran and acetonitrile, to form a quaternary ammonium salt of the lower alkyl 5-bromolevulinate; and b) hydrolyzing the quaternary ammonium salt with an inorganic acid to form an acid addition salt of delta-aminolevulinic acid.

Moens, Luc (Lakewood, CO)

2003-06-24T23:59:59.000Z

296

Viral RNA testing and automation on the bead-based CBNE detection microsystem.  

SciTech Connect (OSTI)

We developed prototype chemistry for nucleic acid hybridization on our bead-based diagnostics platform and we established an automatable bead handling protocol capable of 50 part-per-billion (ppb) sensitivity. We are working towards a platform capable of parallel, rapid (10 minute), raw sample testing for orthogonal (in this case nucleic acid and immunoassays) identification of biological (and other) threats in a single sensor microsystem. In this LDRD we developed the nucleic acid chemistry required for nucleic acid hybridization. Our goal is to place a non-cell associated RNA virus (Bovine Viral Diarrhea, BVD) on the beads for raw sample testing. This key pre-requisite to showing orthogonality (nucleic acid measurements can be performed in parallel with immunoassay measurements). Orthogonal detection dramatically reduces false positives. We chose BVD because our collaborators (UC-Davis) can supply samples from persistently infected animals; and because proof-of-concept field testing can be performed with modification of the current technology platform at the UC Davis research station. Since BVD is a cattle-prone disease this research dovetails with earlier immunoassay work on Botulinum toxin simulant testing in raw milk samples. Demonstration of BVD RNA detection expands the repertoire of biological macromolecules that can be adapted to our bead-based detection. The resources of this late start LDRD were adequate to partially demonstrate the conjugation of the beads to the nucleic acids. It was never expected to be adequate for a full live virus test but to motivate that additional investment. In addition, we were able to reduce the LOD (Limit of Detection) for the botulinum toxin stimulant to 50 ppb from the earlier LOD of 1 ppm. A low LOD combined with orthogonal detection provides both low false negatives and low false positives. The logical follow-on steps to this LDRD research are to perform live virus identification as well as concurrent nucleic acid and immunoassay detection.

Galambos, Paul C.; Bourdon, Christopher Jay; Farrell, Cara M.; Rossito, Paul (University of California at Davis); McClain, Jaime L.; Derzon, Mark Steven; Cullor, James Sterling (University of California at Davis); Rahimian, Kamayar

2008-09-01T23:59:59.000Z

297

Acidizing of Sandstone Reservoirs Using HF and Organic Acids  

E-Print Network [OSTI]

Mud acid, which is composed of HCl and HF, is commonly used to remove the formation damage in sandstone reservoirs. However, many problems are associated with HCl, especially at high temperatures. Formic-HF acids have served as an alternative...

Yang, Fei

2012-10-19T23:59:59.000Z

298

acid succinic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

simulated the laser heating of the succinic acid (this data is still simulation is that infrared heating generates about 10-15 more succinic acid molecules bound to the analyte...

299

Acid Placement in Acid Jetting Treatments in Long Horizontal Wells  

E-Print Network [OSTI]

In the Middle East, extended reach horizontal wells (on the order of 25,000 feet of horizontal displacement) are commonly acid stimulated by jetting acid out of drill pipe. The acid is jetted onto the face of the openhole wellbore as the drill pipe...

Sasongko, Hari

2012-07-16T23:59:59.000Z

300

Acid placement and coverage in the acid jetting process  

E-Print Network [OSTI]

Many open-hole acid treatments are being conducted by pumping acid through jetting ports placed at the end of coiled tubing or drill pipe. The filter-cake on the bore-hole is broken by the jet; the acid-soluble material is dissolved, creating...

Mikhailov, Miroslav I.

2009-05-15T23:59:59.000Z

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Research Gallery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Environmental Monitoring and Research Nanotechnology: The Science of the Small Algae to Biofuels: Squeezing Power from Pond Scum Living with Wildfire: A Shared Community...

302

Crosscutting Research  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

to, and encourage, greater synergy among disciplines and across each of the Clean Coal Research Program (CCRP) core technology areas. Its mission space is bound by...

303

Pantothenic acid biosynthesis in zymomonas  

DOE Patents [OSTI]

Zymomonas is unable to synthesize pantothenic acid and requires this essential vitamin in growth medium. Zymomonas strains transformed with an operon for expression of 2-dehydropantoate reductase and aspartate 1-decarboxylase were able to grow in medium lacking pantothenic acid. These strains may be used for ethanol production without pantothenic acid supplementation in seed culture and fermentation media.

Tao, Luan; Tomb, Jean-Francois; Viitanen, Paul V.

2014-07-01T23:59:59.000Z

304

Laser desorption mass spectrometry for fast DNA analysis  

SciTech Connect (OSTI)

During the past few years, major effort has been directed toward developing mass spectrometry to measure biopolymers because of the great potential benefit to biomedical research. Hellenkamp and his co-workers were the first to report that large polypeptide molecules can be ionized and detected without significant fragmentation when a greater number of nicotinic acid molecules are used as a matrix. This method is now well known as matrix-assisted laser desorption/ionization (MALDI). Since then, various groups have reported measurements of very large proteins by MALDI. Reliable protein analysis by MALDI is more or less well established. However, the application of MALDI to nucleic acids analysis has been found to be much more difficult. Most research on the measurement of nucleic acid by MALDI were stimulated by the Human Genome Project. Up to now, the only method for reliable routine analysis of nucleic acid is gel electrophoresis. Different sizes of nucleic acids can be separated in gel medium when a high electric field is applied to the gel. However, the time needed to separate different sizes of DNA segments usually takes from several minutes to several hours. If MALDI can be successfully used for nucleic acids analysis, the analysis time can be reduced to less than I millisecond. In addition, no tagging with radioactive materials or chemical dyes is needed. In this work, we will review recent progress related to MALDI for DNA analysis.

Chen, C.H.; Ch`ang, L.Y.; Taranenko, N.I.; Allman, S.L.; Tang, K.; Matteson, K.J.

1995-09-01T23:59:59.000Z

305

Critical review of naphthenic acid corrosion  

SciTech Connect (OSTI)

Naphthenic acid corrosion continues to be a reliability issue in refinery distillation units. A review of the subject is presented herein with special focus on field and laboratory data and on areas where research is needed. The review shows that several parameters are known to affect the corrosion process and their individual effect on crude corrosivity are somewhat understood. However, their combined effect is still subject to much controversy. The determination of a critical factor--naphthenic acid content--is still not standardized. It is shown herein that, by arranging the literature findings into three groups (1) furnace tubes and transfer lines, (2) vacuum column and (3) side cut piping, a better agreement of the literature data is achieved.

Tebbal, S. [SET Labs., Inc., Stafford, TX (United States)

1999-11-01T23:59:59.000Z

306

MFR PAPER 1033 Research determin es fatty aCid  

E-Print Network [OSTI]

~1 Preparation of Esters \\leth) I e\\ler lIere preparuJ u\\lng the mClhod :r, "ere \\cparated an d Idenlilied u\\lng , Zook E J Powell B Hackley J Emerson J Brooker. and G M Knobl

307

Research Help  

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308

Jointly Sponsored Research Program Energy Related Research  

SciTech Connect (OSTI)

Cooperative Agreement, DE-FC26-98FT40323, Jointly Sponsored Research (JSR) Program at Western Research Institute (WRI) began in 1998. Over the course of the Program, a total of seventy-seven tasks were proposed utilizing a total of $23,202,579 in USDOE funds. Against this funding, cosponsors committed $26,557,649 in private funds to produce a program valued at $49,760,228. The goal of the Jointly Sponsored Research Program was to develop or assist in the development of innovative technology solutions that will: (1) Increase the production of United States energy resources - coal, natural gas, oil, and renewable energy resources; (2) Enhance the competitiveness of United States energy technologies in international markets and assist in technology transfer; (3) Reduce the nation's dependence on foreign energy supplies and strengthen both the United States and regional economies; and (4) Minimize environmental impacts of energy production and utilization. Under the JSR Program, energy-related tasks emphasized enhanced oil recovery, heavy oil upgrading and characterization, coal beneficiation and upgrading, coal combustion systems development including oxy-combustion, emissions monitoring and abatement, coal gasification technologies including gas clean-up and conditioning, hydrogen and liquid fuels production, coal-bed methane recovery, and the development of technologies for the utilization of renewable energy resources. Environmental-related activities emphasized cleaning contaminated soils and waters, processing of oily wastes, mitigating acid mine drainage, and demonstrating uses for solid waste from clean coal technologies, and other advanced coal-based systems. Technology enhancement activities included resource characterization studies, development of improved methods, monitors and sensors. In general the goals of the tasks proposed were to enhance competitiveness of U.S. technology, increase production of domestic resources, and reduce environmental impacts associated with energy production and utilization. This report summarizes the accomplishments of the JSR Program.

Western Research Institute

2009-03-31T23:59:59.000Z

309

AR Researchers  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for fixed-wing unmanned aerial vehicles with an emphasis in cooperative unmanned vehicle research and intelligent remote sensing. Cal Christensen, M.S., P.E., P.M.P Cal...

310

IR Researchers  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Researchers Eric D. Larsen Eric D. Larsen is a mechanical engineer at the Idaho National Laboratorywith 19 years of experience in design and integration of electro-mechanical and...

311

The urban perspectives of acid rain. Workshop summary  

SciTech Connect (OSTI)

This report documents discussions held during a workshop an Urban Perspective of Acid Rain. The workshop was sponsored by the Office of the Director, National Acid Precipitation Assessment Program (NAPAP). NAPAP anticipates giving increased emphasis to the benefits in urban areas of emissions reductions. The goal of this informal, exploratory workshop was to serve as a first step towards identifying pollutant monitoring, and research and assessment needs to help answer, from an urban perspective, the two key questions posed to NAPAP by Congress: (1) what are the costs, benefits, and effectiveness of the acid rain control program, and (2) what reductions in deposition, rates are needed in order to prevent adverse effects? The workshop addressed research activities needed to respond to these questions. The discussions focused. sequentially, on data needs, data and model availability, and data and modeling gaps. The discussions concentrated on four areas of effects: human health, materials, urban forests, and visibility.

Tonn, B.E.

1993-06-04T23:59:59.000Z

312

acid acetic acid: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of asphaltene deposition that occurs during acid treatments of oil reservoirs. Asphaltenes are present to some degree in most hydrocarbons. Due to the molecular weight of the...

313

Research departments Materials Research Department  

E-Print Network [OSTI]

and alleviate atmospheric pollution in colla- boration with DMU (the National En- vironmental Research Institute Countries is also part of this department. Wind Energy and Atmospheric Physics Department (Formerly

314

Theoretical Population Biology 54, 257 269 (1998) Acidic Deposition, Plant Pests, and the Fate  

E-Print Network [OSTI]

with power plants, smelters or factories. More recent research developments have evidenced the existenceTheoretical Population Biology 54, 257 269 (1998) Acidic Deposition, Plant Pests, and the Fate the abundance of predators is not too small. Numerical simulation shows that increasing acidic load can lead

Gatto, Marino

315

Direct conversion of carboxylate salts to carboxylic acids via reactive extraction  

E-Print Network [OSTI]

the fermentation conversion. In this case, fermentation broth contains ammonium salts (e.g., ammonium acetate, propionate, butyrate, pentanoate). Therefore, the downstream processing steps (including extraction, purification, esterification, and product... separation) must be compatible with the ammonium carboxylate salts formed in the fermentation. This research focuses on converting fermentation broth carboxylate salts into their corresponding acids via “acid springing.” Reactive extraction and thermal...

Xu, Xin

2008-10-10T23:59:59.000Z

316

E-Print Network 3.0 - acid induces npr1-dependent Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

acid induces npr1-dependent Page: << < 1 2 3 4 5 > >> 1 Communicative & Integrative Biology 3:2, 130-138; MarchApril 2010; 2010 Landes Bioscience ReseARCh pApeR Summary: ....

317

E-Print Network 3.0 - attenuates kainic acid-induced Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: attenuates kainic acid-induced Page: << < 1 2 3 4 5 > >> 1 Brain Research, 599 (1992) 57-63 57 ' 1992 Elsevier Science Publishers B.V. All rights...

318

Workshop overview: Arsenic research and risk assessment  

SciTech Connect (OSTI)

The chronic exposure of humans through consumption of high levels of inorganic arsenic (iAs)-contaminated drinking water is associated with skin lesions, peripheral vascular disease, hypertension, and cancers. Additionally, humans are exposed to organic arsenicals when used as pesticides and herbicides (e.g., monomethylarsonic acid, dimethylarsinic acid (DMA{sup V}) also known as cacodylic acid). Extensive research has been conducted to characterize the adverse health effects that result from exposure to iAs and its metabolites to describe the biological pathway(s) that lead to adverse health effects. To further this effort, on May 31, 2006, the United States Environmental Protection Agency (USEPA) sponsored a meeting entitled 'Workshop on Arsenic Research and Risk Assessment'. The invited participants from government agencies, academia, independent research organizations and consultants were asked to present their current research. The overall focus of these research efforts has been to determine the potential human health risks due to environmental exposures to arsenicals. Pursuant in these efforts is the elucidation of a mode of action for arsenicals. This paper provides a brief overview of the workshop goals, regulatory context for arsenical research, mode of action (MOA) analysis in human health risk assessment, and the application of MOA analysis for iAs and DMA{sup V}. Subsequent papers within this issue will present the research discussed at the workshop, ensuing discussions, and conclusions of the workshop.

Sams, Reeder [Integrated Risk Information System Program, National Center for Environmental Assessment, MC: B-243 01, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711 (United States)], E-mail: sams.reeder@epa.gov; Wolf, Douglas C. [Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711 (United States); Ramasamy, Santhini; Ohanian, Ed [Health and Ecological Criteria Division, Office of Science and Technology, Office of Water, United States Environmental Protection Agency, Washington, DC 20460 (United States); Chen, Jonathan [Antimicrobials Division, Office of Pesticide Programs, United States Environmental Protection Agency, Washington, DC 20460 (United States); Lowit, Anna [Health Effects Division, Office of Pesticide Programs, United States Environmental Protection Agency, Washington, DC 20460 (United States)

2007-08-01T23:59:59.000Z

319

Acidic gas capture by diamines  

DOE Patents [OSTI]

Compositions and methods related to the removal of acidic gas. In particular, the present disclosure relates to a composition and method for the removal of acidic gas from a gas mixture using a solvent comprising a diamine (e.g., piperazine) and carbon dioxide. One example of a method may involve a method for removing acidic gas comprising contacting a gas mixture having an acidic gas with a solvent, wherein the solvent comprises piperazine in an amount of from about 4 to about 20 moles/kg of water, and carbon dioxide in an amount of from about 0.3 to about 0.9 moles per mole of piperazine.

Rochelle, Gary (Austin, TX); Hilliard, Marcus (Missouri City, TX)

2011-05-10T23:59:59.000Z

320

Research paper Drug diffusion and binding in ionizable interpenetrating networks  

E-Print Network [OSTI]

Research paper Drug diffusion and binding in ionizable interpenetrating networks from poly) (PVA), poly(acrylic acid) (PAA), and their interpenetrating networks (IPNs) were prepared using by measuring their equilibrium polymer volume fraction, equilibrium swelling ratio, and mesh size. Drug

Peppas, Nicholas A.

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Research Gallery  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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322

Research Highlight  

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323

Research Highlight  

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324

Research Highlight  

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325

Research Highlight  

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326

Research Highlight  

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327

Research Highlight  

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328

Research Highlight  

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329

Research Highlight  

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330

Research Highlight  

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331

Research Highlights  

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332

Research Library  

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333

Research Opportunities  

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334

Research | JCESR  

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335

Research Highlight  

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336

Research Highlight  

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337

Research Highlight  

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338

Altered Amino Acid Sequence Affects Amyloid Formation In A?(25-35)  

E-Print Network [OSTI]

ALTERED AMINO ACID SEQUENCE AFFECTS AMYLOID FORMATION IN A?(25-35) A Senior Scholars Thesis by MORGAN CHATEAU Submitted to the Office of Undergraduate Research Texas A&M University In partial fulfillment of the requirements... for the designation as UNDERGRADUATE RESEARCH SCHOLAR April 2007 Majors: Biochemistry and Genetics ALTERED AMINO ACID SEQUENCE AFFECTS AMYLOID FORMATION IN A?(25-35) A Senior Scholars Thesis by MORGAN CHATEAU Submitted to the Office...

Chateau, Morgan

2007-09-17T23:59:59.000Z

339

Carbonic Acid Pretreatment of Biomass  

SciTech Connect (OSTI)

This project sought to address six objectives, outlined below. The objectives were met through the completion of ten tasks. 1) Solidify the theoretical understanding of the binary CO2/H2O system at reaction temperatures and pressures. The thermodynamics of pH prediction have been improved to include a more rigorous treatment of non-ideal gas phases. However it was found that experimental attempts to confirm theoretical pH predictions were still off by a factor of about 1.8 pH units. Arrhenius experiments were carried out and the activation energy for carbonic acid appears to be substantially similar to sulfuric acid. Titration experiments have not yet confirmed or quantified the buffering or acid suppression effects of carbonic acid on biomass. 2) Modify the carbonic acid pretreatment severity function to include the effect of endogenous acid formation and carbonate buffering, if necessary. It was found that the existing severity functions serve adequately to account for endogenous acid production and carbonate effects. 3) Quantify the production of soluble carbohydrates at different reaction conditions and severity. Results show that carbonic acid has little effect on increasing soluble carbohydrate concentrations for pretreated aspen wood, compared to pretreatment with water alone. This appears to be connected to the release of endogenous acids by the substrate. A less acidic substrate such as corn stover would derive benefit from the use of carbonic acid. 4) Quantify the production of microbial inhibitors at selected reaction conditions and severity. It was found that the release of inhibitors was correlated to reaction severity and that carbonic acid did not appear to increase or decrease inhibition compared to pretreatment with water alone. 5) Assess the reactivity to enzymatic hydrolysis of material pretreated at selected reaction conditions and severity. Enzymatic hydrolysis rates increased with severity, but no advantage was detected for the use of carbonic acid compared to water alone. 6) Determine optimal conditions for carbonic acid pretreatment of aspen wood. Optimal severities appeared to be in the mid range tested. ASPEN-Plus modeling and economic analysis of the process indicate that the process could be cost competitive with sulfuric acid if the concentration of solids in the pretreatment is maintained very high (~50%). Lower solids concentrations result in larger reactors that become expensive to construct for high pressure applications.

G. Peter van Walsum; Kemantha Jayawardhana; Damon Yourchisin; Robert McWilliams; Vanessa Castleberry

2003-05-31T23:59:59.000Z

340

University of California, Irvine Environmental Health and Safety www.ehs.uci.edu Questions Call: (949) 824-6200 Version 2.1 Ethidium bromide is a commonly used stain for identifying nucleic acids in electrophoresis gels. It is  

E-Print Network [OSTI]

&S hazardous waste label and placed in secondary containment. Do not use a biohazardous waste bag to package bromide solutions must be treated as part of the experimental protocol or managed as a hazardous chemical is saturated, the charcoal must be managed as a hazardous chemical waste and disposed of through EH&S. Charcoal

George, Steven C.

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Research | Energy Frontier Research Centers  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

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342

Research | Photosynthetic Antenna Research Center  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation Desert Southwest RegionatSearch Welcome toResearch Areas OurLANLSoftwareCenterResearch

343

Research and Development with Full Scale Research  

E-Print Network [OSTI]

One of the research programs of the Energy research Centre of the Netherlands (ECN) concerns the built environment. Several facilities to conduct the research activities are at ECN's disposal. One of these facilities, are five research dwellings...

Sijpheer, N.; Bakker, E.J.; Opstelten, I.

2010-01-01T23:59:59.000Z

344

Global Health Research | 2 Global Health Research  

E-Print Network [OSTI]

Global Health Research | 2 Global Health Research Supporting researchers in low- and middle-income countries to carry out health- related research within their own countries. Gl bal Health #12;3 | Global Health Research #12;Global Health Research | 4 We are a global charitable foundation dedicated

Rambaut, Andrew

345

Metabolism of Thioctic Acid in Algae  

E-Print Network [OSTI]

METABOLISM OF THlOCTlC ACID IN ALGAE TWO-WEEK LOAN COPY ThisMETABOLISM OF THIOCTIC ACID IN ALGAE Hans Grisebach, R. , C.METABOLISM OF THIOCTIC ACID IN ALGAE Hans Grisebach, R. C.

Grisebach, Hans; Fuller, R.C.; Calvin, M.

1956-01-01T23:59:59.000Z

346

Solvent extraction of inorganic acids  

E-Print Network [OSTI]

the solution by a sim?. le process that is economically =ttrsctlve is of con- sider. ble interest~ Dilute "olution; of hydrochloric, nitric and sul- furic acid d; occur in many processes either alone or toga- th: r . 'he use of li. , uid-li~uid extraction...~~ram for hexyl c~rbitol- water-nitric acid 17 ~ Distribution die, r m for hoxl'' ca:-bitol- watcr-sulfur'c acid Table 1. . 'xperimental d ta of amyl alcohol-water-!!Cl Pa, e 33 2. Experimental data of isoamyl alcohol-water- HC1 34 3 ~ Cxperimental data...

Ysrael, Miguel Curie

1965-01-01T23:59:59.000Z

347

acetic acid solutions: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In the present study, bonding among formic, acetic and benzoic acids, sulfuric acid, ammonia, acetic, and benzoic acids with free and hydrated sulfuric acid has been...

348

arachidonic acid activation: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In the present study, bonding among formic, acetic and benzoic acids, sulfuric acid, ammonia, acetic, and benzoic acids with free and hydrated sulfuric acid has been...

349

acid inertness studies: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In the present study, bonding among formic, acetic and benzoic acids, sulfuric acid, ammonia, acetic, and benzoic acids with free and hydrated sulfuric acid has been...

350

acid activated montmorillonite: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In the present study, bonding among formic, acetic and benzoic acids, sulfuric acid, ammonia, acetic, and benzoic acids with free and hydrated sulfuric acid has been...

351

acid amide hydrolase: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In the present study, bonding among formic, acetic and benzoic acids, sulfuric acid, ammonia, acetic, and benzoic acids with free and hydrated sulfuric acid has been studied....

352

acid chelation phototherapeutic: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In the present study, bonding among formic, acetic and benzoic acids, sulfuric acid, ammonia, acetic, and benzoic acids with free and hydrated sulfuric acid has been...

353

acid phosphatase activity: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In the present study, bonding among formic, acetic and benzoic acids, sulfuric acid, ammonia, acetic, and benzoic acids with free and hydrated sulfuric acid has been...

354

acetic acid solution: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In the present study, bonding among formic, acetic and benzoic acids, sulfuric acid, ammonia, acetic, and benzoic acids with free and hydrated sulfuric acid has been...

355

acetic acid operational: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In the present study, bonding among formic, acetic and benzoic acids, sulfuric acid, ammonia, acetic, and benzoic acids with free and hydrated sulfuric acid has been...

356

acid phosphatase activities: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In the present study, bonding among formic, acetic and benzoic acids, sulfuric acid, ammonia, acetic, and benzoic acids with free and hydrated sulfuric acid has been...

357

acid sphingomyelinase activity: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In the present study, bonding among formic, acetic and benzoic acids, sulfuric acid, ammonia, acetic, and benzoic acids with free and hydrated sulfuric acid has been...

358

acids decreases fibrinolysis: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In the present study, bonding among formic, acetic and benzoic acids, sulfuric acid, ammonia, acetic, and benzoic acids with free and hydrated sulfuric acid has been...

359

arachidonic acid activates: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In the present study, bonding among formic, acetic and benzoic acids, sulfuric acid, ammonia, acetic, and benzoic acids with free and hydrated sulfuric acid has been...

360

acid decarboxylase activity: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In the present study, bonding among formic, acetic and benzoic acids, sulfuric acid, ammonia, acetic, and benzoic acids with free and hydrated sulfuric acid has been...

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

acid activates nrf2: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In the present study, bonding among formic, acetic and benzoic acids, sulfuric acid, ammonia, acetic, and benzoic acids with free and hydrated sulfuric acid has been...

362

acid processing activity: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In the present study, bonding among formic, acetic and benzoic acids, sulfuric acid, ammonia, acetic, and benzoic acids with free and hydrated sulfuric acid has been...

363

ascorbic acid enhances: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In the present study, bonding among formic, acetic and benzoic acids, sulfuric acid, ammonia, acetic, and benzoic acids with free and hydrated sulfuric acid has been...

364

acid cupric chloride: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In the present study, bonding among formic, acetic and benzoic acids, sulfuric acid, ammonia, acetic, and benzoic acids with free and hydrated sulfuric acid has been...

365

University Research  

Office of Science (SC) Website

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched5 Industrial CarbonArticles News News Homeuniversity-research/ The Office of Science

366

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassive Solar HomePromisingStories » RemovingResearchGallery

367

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassive Solar HomePromisingStories » RemovingResearchGalleryAre Increases in

368

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassive Solar HomePromisingStories » RemovingResearchGalleryAre Increases inSatellite

369

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassive Solar HomePromisingStories » RemovingResearchGalleryAre Increases

370

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassive Solar HomePromisingStories » RemovingResearchGalleryAre IncreasesEvaluation

371

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassive Solar HomePromisingStories » RemovingResearchGalleryAre

372

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassive Solar HomePromisingStories » RemovingResearchGalleryAreQuantifying the

373

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassive Solar HomePromisingStories » RemovingResearchGalleryAreQuantifying

374

Research Projects  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassive Solar HomePromisingStories »Submitter A B C D E F G H I J KAustin » Research

375

PNNL: Research  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation Desert Southwest RegionatSearch Welcome to the Pacific Northwest National LaboratoryResearch

376

Research Areas  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation Desert Southwest RegionatSearch Welcome toResearch Areas Our Vision National User Facilities

377

Research Areas  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation Desert Southwest RegionatSearch Welcome toResearch Areas Our Vision National User

378

Research Techniques  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation Desert Southwest RegionatSearch Welcome toResearch Areas OurLANL

379

Research Tools  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation Desert Southwest RegionatSearch Welcome toResearch Areas OurLANLSoftware & Tools

380

Research | NREL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation Desert Southwest RegionatSearch Welcome toResearch Areas OurLANLSoftwareCenter

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared at 278, 298,NIST31 ORVEnergyResearch Form

382

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared at 278, 298,NIST31 ORVEnergyResearch FormGeneral Formulation

383

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared at 278, 298,NIST31 ORVEnergyResearch FormGeneral FormulationAn

384

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared at 278, 298,NIST31 ORVEnergyResearch FormGeneral

385

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared at 278, 298,NIST31 ORVEnergyResearch FormGeneralIntegrated

386

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared at 278, 298,NIST31 ORVEnergyResearch

387

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared at 278, 298,NIST31 ORVEnergyResearchCloud Observations at

388

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared at 278, 298,NIST31 ORVEnergyResearchCloud Observations atARM

389

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared at 278, 298,NIST31 ORVEnergyResearchCloud Observations

390

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared at 278, 298,NIST31 ORVEnergyResearchCloud

391

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared at 278, 298,NIST31 ORVEnergyResearchCloudObservational

392

Research Highlight  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared at 278, 298,NIST31 ORVEnergyResearchCloudObservationalA

393

In vivo incorporation of unnatural amino acids  

DOE Patents [OSTI]

The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.

Schultz, Peter G. (La Jolla, CA); Wang, Lei (San Diego, CA); Anderson, John Christopher (San Diego, CA); Chin, Jason W. (Cambridge, GB); Liu, David R. (Lexington, MA); Magliery, Thomas J. (North Haven, CT); Meggers, Eric L. (Philadelphia, PA); Mehl, Ryan Aaron (Lancaster, PA); Pastrnak, Miro (San Diego, CA); Santoro, Stephen William (Cambridge, MA); Zhang, Zhiwen (San Diego, CA)

2012-05-08T23:59:59.000Z

394

Carbonic Acid Shows Promise in Geology, Biology  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

The Surprising Secrets of Carbonic Acid Probing the Surprising Secrets of Carbonic Acid Berkeley Lab Study Holds Implications for Geological and Biological Processes October 23,...

395

Mineralogical transformations controlling acid mine drainage...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mineralogical transformations controlling acid mine drainage chemistry. Mineralogical transformations controlling acid mine drainage chemistry. Abstract: The role of Fe(III)...

396

Phytozome: A Comparative Platform for Green Plant Genomics  

E-Print Network [OSTI]

a growing plant comparative genomics resource. Nucleic AcidsL.A. (2011) The Sol Genomics Network (solgenomics.net):for comparative plant genomics. Nucleic Acids Res, 36, D959-

Goodstein, David M.

2012-01-01T23:59:59.000Z

397

E-Print Network 3.0 - antisense oligonucleotide lna Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

block mRNA translation (3, 4). Below we describe... RNA using locked nucleic acid (LNA) technology. LNAs are nucleic acid analogs in which the ribose ring... is "locked" by a...

398

Method of detecting genetic deletions identified with chromosomal abnormalities  

DOE Patents [OSTI]

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyzes. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acids probes are typically of a complexity greater tha 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particlularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML) and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar ut genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W; Pinkel, Daniel; Tkachuk, Douglas

2013-11-26T23:59:59.000Z

399

Chromosome-specific staining to detect genetic rearrangements  

DOE Patents [OSTI]

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyzes. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML) and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W.; Pinkel, Daniel; Tkachuk, Douglas; Westbrook, Carol

2013-04-09T23:59:59.000Z

400

Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17  

DOE Patents [OSTI]

Methods and compositions for staining based upon nucleic acid sequence that employ .[.nudeic.]. .Iadd.nucleic .Iaddend.acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W. (San Francisco, CA); Pinkel, Daniel (Lafayette, CA); Kallioniemi, Olli-Pekka (Turku, FI); Kallioniemi, Anne (Tampere, FI); Sakamoto, Masaru (Tokyo, JP)

2009-10-06T23:59:59.000Z

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Chromosome-Specific Staining To Detect Genetic Rearrangements Associated With Chromosome 3 And/Or Chromosone 17  

DOE Patents [OSTI]

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray; Joe W. (Livermore, CA); Pinkel; Daniel (Walnut Creek, CA); Kallioniemi; Olli-Pekka (Tampere, FI); Kallioniemi; Anne (Tampere, FI); Sakamoto; Masaru (Tokyo, JP)

2002-02-05T23:59:59.000Z

402

Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17  

DOE Patents [OSTI]

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W. (San Francisco, CA); Pinkel, Daniel (Lafayette, CA); Kallioniemi, Olli-Pekka (Turku, FI); Kallioniemi, Anne (Tampere, FI); Sakamoto, Masaru (Tokyo, JP)

2008-09-09T23:59:59.000Z

403

Method of detecting genetic translocations identified with chromosomal abnormalities  

DOE Patents [OSTI]

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML) and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Gray, Joe W. (Livermore, CA); Pinkel, Daniel (Walnut Creek, CA); Tkachuk, Douglas (Livermore, CA)

2001-01-01T23:59:59.000Z

404

Seasonalepisodic control of acid deposition  

E-Print Network [OSTI]

This report contains the climatological, technical and economic factors for episodic and seasonal control of emissions in existing power plants. Analyzing a large data set of acid deposition for the years 1982-85, we find ...

Fay, James A.

1988-01-01T23:59:59.000Z

405

Asphaltene damage in matrix acidizing  

E-Print Network [OSTI]

This work addresses the problem of asphaltene deposition that occurs during acid treatments of oil reservoirs. Asphaltenes are present to some degree in most hydrocarbons. Due to the molecular weight of the components these asphaltenes are more...

Hinojosa, Roberto Antonio

2012-06-07T23:59:59.000Z

406

Controlling acid rain : policy issues  

E-Print Network [OSTI]

The policy and regulatory ramifications of U.S. acid rain control programs are examined; particularly, the alternative of a receptor-oriented strategy as constrasted to emission-oriented proposals (e.g., the Mitchell bill) ...

Fay, James A.

1983-01-01T23:59:59.000Z

407

Nitrate and Prussic Acid Poisoning  

E-Print Network [OSTI]

Nitrate and prussic acid poisoning in cattle are noninfectious conditions that can kill livestock. This publication explains the causes and symptoms of these conditions as well as preventive measures and sampling and testing steps....

Stichler, Charles; Reagor, John C.

2001-09-05T23:59:59.000Z

408

High Level Waste System Impacts from Acid Dissolution of Sludge  

SciTech Connect (OSTI)

This research evaluates the ability of OLI{copyright} equilibrium based software to forecast Savannah River Site High Level Waste system impacts from oxalic acid dissolution of Tank 1-15 sludge heels. Without further laboratory and field testing, only the use of oxalic acid can be considered plausible to support sludge heel dissolution on multiple tanks. Using OLI{copyright} and available test results, a dissolution model is constructed and validated. Material and energy balances, coupled with the model, identify potential safety concerns. Overpressurization and overheating are shown to be unlikely. Corrosion induced hydrogen could, however, overwhelm the tank ventilation. While pH adjustment can restore the minimal hydrogen generation, resultant precipitates will notably increase the sludge volume. OLI{copyright} is used to develop a flowsheet such that additional sludge vitrification canisters and other negative system impacts are minimized. Sensitivity analyses are used to assess the processability impacts from variations in the sludge/quantities of acids.

KETUSKY, EDWARD

2006-04-20T23:59:59.000Z

409

Factors controlling naphthenic acid corrosion  

SciTech Connect (OSTI)

A laboratory study was conducted to elucidate the influence of chemical and physical parameters on corrosion of type 1018 carbon steel (CS, UNS G10180) and 5% Cr-0.5% Mo steel in oils containing naphthenic acids (NAs) for application to crude oil refinery systems. Effects of test duration, temperature, and acid concentration were assessed for a range of single acids of varying carbon numbers and for NA mixtures in mineral oil (MO) and in heavy vacuum gas oil (HGVO). In addition, a limited study of the effect of hydrogen sulfide (H{sub 2}S) addition to the acid-oil mixture was conducted. Use of the total acid number (TAN) as a measure of corrosiveness of a crude oil was discredited further. For the same TAN value, molecular size and structure of the acid were shown to have an important influence. Tests conducted in HGVO showed lower corrosion rates than in MO, suggesting inhibition caused by S species in the oil or the steric hindrance of naphtheno-aromatic acids. In oil containing the mixture of NAs, the corrosion rate of type 1018 CS was lower than that for 5% Cr-0.5% Mo steel. The 0.1% H{sub 2}S that passed through the acid-oil mixtures had an inhibiting effect on corrosion. Predicting corrosiveness of a crude oil from the measurement of TAN, distribution of NA composition, and S content and form was particularly challenging. The simple tests used were informative, but further work will be required to establish a standard test method that can provide an adequate ranking of crudes.

Turnbull, A. [National Physical Lab., Teddington (United Kingdom); Slavcheva, E. [Bulgarian Academy of Sciences, Sofia (Bulgaria); Shone, B. [Ty Isa, Nr Mold (United Kingdom)

1998-11-01T23:59:59.000Z

410

Fuel Cell Applied Research Project  

SciTech Connect (OSTI)

Since November 12, 2003, Northern Alberta Institute of Technology has been operating a 200 kW phosphoric acid fuel cell to provide electrical and thermal energy to its campus. The project was made possible by funding from the U.S. Department of Energy as well as by a partnership with the provincial Alberta Energy Research Institute; a private-public partnership, Climate Change Central; the federal Ministry of Western Economic Development; and local natural gas supplier, ATCO Gas. Operation of the fuel cell has contributed to reducing NAIT's carbon dioxide emissions through its efficient use of natural gas.

Lee Richardson

2006-09-15T23:59:59.000Z

411

2010 ANNUAL RESEARCH REPORT 2010 ANNUAL RESEARCH REPORT 2010 ANNUAL RESEARCH REPORT RESEARCH REPORT2010ANNUAL RESEARCH REPORT2010ANNUAL RESEARCH REPORT  

E-Print Network [OSTI]

2010 ANNUAL RESEARCH REPORT 2010 ANNUAL RESEARCH REPORT 2010 ANNUAL RESEARCH REPORT RESEARCH REPORT2010ANNUAL RESEARCH REPORT2010ANNUAL RESEARCH REPORT 2010 ANNUAL RESEARCH REPORT 2010 ANNUAL RESEARCH REPORT 2010 ANNUAL RESEARCH REPORT RESEARCH REPORT2010ANNUAL RESEARCH REPORT2010ANNUAL RESEARCH REPORT

Jawitz, James W.

412

Multiplex automated genome engineering  

DOE Patents [OSTI]

The present invention relates to automated methods of introducing multiple nucleic acid sequences into one or more target cells.

Church, George M; Wang, Harris H; Isaacs, Farren J

2013-10-29T23:59:59.000Z

413

Acid sorption regeneration process using carbon dioxide  

DOE Patents [OSTI]

Carboxylic acids are sorbed from aqueous feedstocks onto a solid adsorbent in the presence of carbon dioxide under pressure. The acids are freed from the sorbent phase by a suitable regeneration method, one of which is treating them with an organic alkylamine solution thus forming an alkylamine-carboxylic acid complex which thermally decomposes to the desired carboxylic acid and the alkylamine.

King, C. Judson (Kensington, CA); Husson, Scott M. (Anderson, SC)

2001-01-01T23:59:59.000Z

414

Succinic acid production by Anaerobiospirillum succiniciproducens  

E-Print Network [OSTI]

, succinic acid has been produced commercially by chemical processes. Recently, however, fermentative of bacteria produce succinic acid as a fermentation end product,4 7 few species can produce it as the major 10 Previous studies showed that A. succiniciproducens produces succinic acid and acetic acid

415

Instrument Application Capabilities Advantages Disadvantages Recommendations Contact Qiagen Qiacube  

E-Print Network [OSTI]

@uthsc.edu Agilent Bioanalyzer Quality control Profiles for total RNA; enriched mRNA; enriched small RNA; DNA Nucleic acid isolation and purification Total RNA; miRNA; DNA; All prep (all nucleic acid) 2-12 samples Felicia Waller fwaller@uthsc.edu Nanodrop Spectrophotometer Nucleic acids quantification and quality

Cui, Yan

416

Red-shifted fluorescent proteins mPlum and mRaspberry and polynucleotides encoding the same  

DOE Patents [OSTI]

Methods using somatic hypermutation (SHM) for producing polypeptide and nucleic acid variants, and nucleic acids encoding such polypeptide variants are disclosed. Such variants may have desired properties. Also disclosed are novel polypeptides, such as improved fluorescent proteins, produced by the novel methods, and nucleic acids, vectors, and host cells comprising such vectors.

Tsien, Roger Y. (La Jolla, CA); Wang, Lei (San Diego, CA)

2008-07-01T23:59:59.000Z

417

Methods for making nucleotide probes for sequencing and synthesis  

DOE Patents [OSTI]

Compositions and methods for making a plurality of probes for analyzing a plurality of nucleic acid samples are provided. Compositions and methods for analyzing a plurality of nucleic acid samples to obtain sequence information in each nucleic acid sample are also provided.

Church, George M; Zhang, Kun; Chou, Joseph

2014-07-08T23:59:59.000Z

418

3284 E Exobiology (theoretical), Complexity in Exobiology (theoretical),  

E-Print Network [OSTI]

to as enzymes. Nucleotides and nucleic acids Nucleotides are mono- mers of nucleic acids, e. g., of RNA bases) that can pair in a specific way. Nucleotides can form polymers, and their sequence carries water molecule is removed in this step. Other nucleotides of interest include peptide nucleic acid

Brandenburg, Axel

419

National Centre for Biological Sciences Mass Spectrometry Facility  

E-Print Network [OSTI]

: Sample Information Number of samples: Sample ID: Concentration: Solubility: Expected mass (Da): Molecular: Protein Peptide Lipid Nucleic acid Others (specify) Analysis Requirement ESI MS, low resolution ESI MS, high resolution LC-ESI MS LC-ESI MS/MS Others (specify) Signature of research supervisor: Signature

Bhalla, Upinder S.

420

Proceedings of the National Academy of Sciences USA 94: 1454214546.  

E-Print Network [OSTI]

in the gastric pathogen Helicobacter pylori. Nucleic Acids Research 20: 6221­6225. Albert, T. J. et al. (2005). Mutation discovery in bacte- rial genomes: metronidazole resistance in Helicobacter pylori. Nature Methods. (1999a). Recombination and clonal groupings within Helicobacter pylori from different geo- graphical

Alberts, Susan C

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Parallel Picoliter RT-PCR Assays Using Microfluidics  

E-Print Network [OSTI]

Parallel Picoliter RT-PCR Assays Using Microfluidics Joshua S. Marcus,, W. French Anderson The development of microfluidic tools for high-throughput nucleic acid analysis has become a burgeoning area of research in the post-genome era. Here, we have developed a microfluidic chip to perform 72 parallel 450-p

Quake, Stephen R.

422

Research and Commercialization Grants  

Broader source: Energy.gov [DOE]

The Board of Research and Commercialization Technology provides grants for renewable resource research and development projects, among other types, to be conducted at research and commercialization...

423

Research Library Discontinues OPPIE  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

About the Library Research Library Discontinues OPPIE Research Library Discontinues OPPIE Find more information below. Questions? 505-667-5809 Email The Research Library is...

424

Method for production of petroselinic acid and OMEGA12 hexadecanoic acid in transgenic plants  

DOE Patents [OSTI]

The present invention relates to a process for producing lipids containing the fatty acid petroselinic acid in plants. The production of petroselinic acid is accomplished by genetically transforming plants which do not normally accumulate petroselinic acid with a gene for a .omega.12 desaturase from another species which does normally accumulate petroselinic acid.

Ohlrogge, John B. (Okemos, MI); Cahoon, Edgar B. (Lansing, MI); Shanklin, John (Upton, NY); Somerville, Christopher R. (Okemos, MI)

1995-01-01T23:59:59.000Z

425

Method for production of petroselinic acid and OMEGA12 hexadecanoic acid in transgenic plants  

DOE Patents [OSTI]

The present invention relates to a process for producing lipids containing the fatty acid, petroselinic acid, in plants. The production of petroselinic acid is accomplished by genetically transforming plants which do not normally accumulate petroselinic acid with a gene for a {omega}12 desaturase from another species which does normally accumulate petroselinic acid. 19 figs.

Ohlrogge, J.B.; Cahoon, E.B.; Shanklin, J.; Somerville, C.R.

1995-07-04T23:59:59.000Z

426

New syntheses of aminoalkylphosphonic acids  

E-Print Network [OSTI]

NEW SYNTHESES OF AMINOALKYLPHOSPHON1C ACIDS A Thesis by John Frederick DeBardeleben, Jr. Su'bmitted to the Graduate School of the Agricultural and Mechanical College of Texas in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE August 196$ Major Subject: Chemistry NEW SYNTHESES OF AMINOALKYLPHOSPHONIC ACIDS A Thesis BY John Frederick DeBardeleben, Jr. Approved as to style and content hy: (Chairman of Committee) iJ C wc+'. A-c-~-' & (Head of Department...

DeBardeleben, John Frederick

2012-06-07T23:59:59.000Z

427

Energy technology and emissions control for acid rain abatement in Asia  

SciTech Connect (OSTI)

After more than ten years of research, acid rain is a sufficiently serious problem in North America to warrant control action. The acid rain problem has become a threat to the Asian continent as well. Emissions of sulfur dioxide and nitrogen oxides are already high and announces plans for increases in coal use by countries in the region imply a major increase in emissions in the future. This will inevitably lead to greater incidence of acid rain and probably significant environmental damage in some locations. The purpose of this paper is to examine some of the issues relating to acid-rain-control technology in Asia and to suggest ways to include technology options in integrated simulation models of acid rain in Asia. 14 refs., 9 figs., 6 tabs. (FL)

Streets, D.G.

1990-01-01T23:59:59.000Z

428

Introduction of biotin or folic acid into polypyrrole magnetite core-shell nanoparticles  

SciTech Connect (OSTI)

In order to contribute to the trend in contemporary research to develop magnetic core shell nanoparticles with better properties (reduced toxicity, high colloidal and chemical stability, wide scope of application) in straightforward and reproducible methods new core shell magnetic nanoparticles were developed based on polypyrrole shells functionalized with biotin and folic acid. Magnetite nanoparticles stabilized by sebacic acid were used as magnetic cores. The morphology of magnetite was determined by transmission electron microscopy TEM, while the chemical structure investigated by FT-IR.

Nan, Alexandrina; Turcu, Rodica [National Institute of Research and Development for Isotopic and Molecular Technologies, Donath 65-103, Cluj-Napoca (Romania)] [National Institute of Research and Development for Isotopic and Molecular Technologies, Donath 65-103, Cluj-Napoca (Romania); Liebscher, Jürgen [National Institute of Research and Development for Isotopic and Molecular Technologies, Donath 65-103, Cluj-Napoca, Romania and Institute of Chemistry, Humboldt-University Berlin, Brook-Taylor 2, D-12489 Berlin (Germany)] [National Institute of Research and Development for Isotopic and Molecular Technologies, Donath 65-103, Cluj-Napoca, Romania and Institute of Chemistry, Humboldt-University Berlin, Brook-Taylor 2, D-12489 Berlin (Germany)

2013-11-13T23:59:59.000Z

429

Acid Catalysis in Modern Organic  

E-Print Network [OSTI]

catalyst for organic synthesis". That is the starting sentence of this book by Yamamoto and Ishihara, which follows their earlier book "Lewis Acids in Organic Synthesis (2000)", and covers the new developments book that should be available in every well-equipped chemistry library. It will certainly be helpful

Snyder, Scott A.

430

HYDROFLUORIC ACID FIRST AID INSTRUCTIONS  

E-Print Network [OSTI]

with large amounts of cool running water. Immediately washing off the acid is of primary importance. 2.Remove Immediately flush eyes for at least 15 minutes with copious cool flowing water. 2 If only one eye is affected by a glass of milk or milk of magnesia. 3 Call 911 for immediate medical assistance. REMEMBER, ALL PERSONNEL

Jalali. Bahram

431

Energy Frontier Research Centers | ORNL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Materials Home | Science & Discovery | Advanced Materials | Research Areas | Energy Frontier Research Centers SHARE Energy Frontier Research Centers Advanced Materials research...

432

E-Print Network 3.0 - acid acetylsalicylic acid Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Acids are kept in storage cabinets under the fume hood... in the plastic box. 3. Place filters in hood, add 50% (approximate concentration) HCl acid (Fisher, certified ACS......

433

E-Print Network 3.0 - acid methoxyacetic acid Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Acids are kept in storage cabinets under the fume hood... in the plastic box. 3. Place filters in hood, add 50% (approximate concentration) HCl acid (Fisher, certified ACS......

434

E-Print Network 3.0 - acidic alpha-amino acids Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Acids are kept in storage cabinets under the fume hood... in the plastic box. 3. Place filters in hood, add 50% (approximate concentration) HCl acid (Fisher, certified ACS......

435

E-Print Network 3.0 - acid sorbic acid Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Acids are kept in storage cabinets under the fume hood... in the plastic box. 3. Place filters in hood, add 50% (approximate concentration) HCl acid (Fisher, certified ACS......

436

E-Print Network 3.0 - acid dichloroacetic acid Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Acids are kept in storage cabinets under the fume hood... in the plastic box. 3. Place filters in hood, add 50% (approximate concentration) HCl acid (Fisher, certified ACS......

437

E-Print Network 3.0 - acid n-glycolylneuraminic acid Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Acids are kept in storage cabinets under the fume hood... in the plastic box. 3. Place filters in hood, add 50% (approximate concentration) HCl acid (Fisher, certified ACS......

438

E-Print Network 3.0 - acids organic acids Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in the decomposition of organic material, is the primary source of acidity in unpolluted rainwater. NOTE: Parts per... A ACID RAIN Audrey Gibson ATOC 3500 Thursday, April ......

439

E-Print Network 3.0 - acid propionic acid Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by Explorit Topic List Advanced Search Sample search results for: acid propionic acid Page: << < 1 2 3 4 5 > >> 1 Biodegradation 9: 463473, 1998. 1998 Kluwer Academic...

440

E-Print Network 3.0 - acid linoleic acid Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

FAs (linolenic, linoleic) - - monounsaturated FAs (oleic acid) - olive, canola - hydrogenation... Biol 458 Lecture 6 & 7 Fatty Acids 1 A. Introduction to acyl lipids...

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Modeling of Acid Fracturing in Carbonate Reservoirs  

E-Print Network [OSTI]

The acid fracturing process is a thermal, hydraulic, mechanical, and geochemical (THMG)-coupled phenomena in which the behavior of these variables are interrelated. To model the flow behavior of an acid into a fracture, mass and momentum balance...

Al Jawad, Murtada s

2014-06-05T23:59:59.000Z

442

Fuel cell electrolyte membrane with acidic polymer  

DOE Patents [OSTI]

An electrolyte membrane is formed by an acidic polymer and a low-volatility acid that is fluorinated, substantially free of basic groups, and is either oligomeric or non-polymeric.

Hamrock, Steven J. (Stillwater, MN); Larson, James M. (Saint Paul, MN); Pham, Phat T. (Little Canada, MN); Frey, Matthew H. (Cottage Grove, MN); Haugen, Gregory M. (Edina, MN); Lamanna, William M. (Stillwater, MN)

2009-04-14T23:59:59.000Z

443

Recovery of mercury from acid waste residues  

DOE Patents [OSTI]

Mercury can be recovered from nitric acid-containing fluids by reacting the fluid with aluminum metal to produce mercury metal, and thence quenching the reactivity of the nitric acid prior to nitration of the mercury metal. 1 fig.

Greenhalgh, W.O.

1987-02-27T23:59:59.000Z

444

Recovery of mercury from acid waste residues  

DOE Patents [OSTI]

Mercury can be recovered from nitric acid-containing fluids by reacting the fluid with aluminum metal to produce mercury metal, and then quenching the reactivity of the nitric acid prior to nitration of the mercury metal.

Greenhalgh, Wilbur O. (Richland, WA)

1989-01-01T23:59:59.000Z

445

Sarnoff Cardiovascular Sarnoff Cardiovascular Research Foundation Research Foundation  

E-Print Network [OSTI]

Sarnoff Cardiovascular Sarnoff Cardiovascular Research Foundation Research Foundation Medical Research Foundation Research Foundation Medical Student Research Fellowships Scientists of Tomorrow #12 medical Provides medical Sarnoff Cardiovascular Sarnoff Cardiovascular Research Foundation Research

Bushman, Frederic

446

amino acid intake: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

protein intake (PDI) and net portal appearance rate of amino acids by continuous infusion of para-aminohippuric acid via the mesenteric catheter. The amino-acid appearance...

447

Reactions Between Water Soluble Organic Acids and Nitrates in...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Reactions Between Water Soluble Organic Acids and Nitrates in Atmospheric Aerosols: Recycling of Nitric Acid and Formation of Reactions Between Water Soluble Organic Acids and...

448

acid synthase impacts: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

acid utilization and glucose oxidation. Glucose... Adhikari, Sean 2006-10-30 246 ANTIBODY PURIFICATION USING CAPRYLIC ACID In mildly acidic conditions, the addition of short-chain...

449

Nanoplasmonic molecular ruler for nuclease activity and DNA footprinting  

DOE Patents [OSTI]

This invention provides a nanoplasmonic molecular ruler, which can perform label-free and real-time monitoring of nucleic acid (e.g., DNA) length changes and perform nucleic acid footprinting. In various embodiments the ruler comprises a nucleic acid attached to a nanoparticle, such that changes in the nucleic acid length are detectable using surface plasmon resonance. The nanoplasmonic ruler provides a fast and convenient platform for mapping nucleic acid-protein interactions, for nuclease activity monitoring, and for other footprinting related methods.

Chen, Fanqing Frank; Liu, Gang L; Lee, Luke P

2013-10-29T23:59:59.000Z

450

ENERGY GENERATION RESEARCH PIER Energy Generation Research  

E-Print Network [OSTI]

ENERGY GENERATION RESEARCH PIER Energy Generation Research www.energy.ca.gov/research/ renewable/ November 2010 Sonoma County RESCO A Local Level Approach to Renewable Energy Portfolios. The Issue To address energy usage that contributes to climate change, California has enacted legislation to guide

451

Unnatural reactive amino acid genetic code additions  

DOE Patents [OSTI]

This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.

Deiters, Alexander; Cropp, T. Ashton; Chin, Jason W.; Anderson, J. Christopher; Schultz, Peter G.

2014-08-26T23:59:59.000Z

452

Organic Acid Production by Filamentous Fungi  

E-Print Network [OSTI]

-being. Indeed, organic acid fermentations are often not even identified as fungal bioprocesses, having been Aspergillus niger in aerated stirred-tank-reactors can convert glucose to citric acid with greater than 80 lipolytica, and related yeast species, may be in use commercially to produce citric acid (Lopez-Garcia, 2002

453

Unnatural reactive amino acid genetic code additions  

DOE Patents [OSTI]

This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNAsyn-thetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.

Deiters, Alexander (La Jolla, CA); Cropp, T. Ashton (Bethesda, MD); Chin, Jason W. (Cambridge, GB); Anderson, J. Christopher (San Francisco, CA); Schultz, Peter G. (La Jolla, CA)

2011-08-09T23:59:59.000Z

454

Unnatural reactive amino acid genetic code additions  

DOE Patents [OSTI]

This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.

Deiters, Alexander; Cropp, Ashton T; Chin, Jason W; Anderson, Christopher J; Schultz, Peter G

2013-05-21T23:59:59.000Z

455

Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters  

DOE Patents [OSTI]

A process is disclosed for preparing an acid addition salt of delta-aminolevulinic acid comprising. The process involves dissolving a lower alkyl 5-bromolevulinate and an alkali metal diformylamide in an organic solvent selected from the group consisting of acetonitrile, methanol, tetrahydrofuran, 2-methyltetrahydrofuran and methylformate or mixtures to form a suspension of an alkyl 5-(N,N-diformylamino) levulinate ester; and hydrolyzing the alkyl 5-(N,N-diformylamino) levulinate with an inorganic acid to form an acid addition salt of delta-amino levulinic acid.

Moens, L.

1999-05-25T23:59:59.000Z

456

Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters  

DOE Patents [OSTI]

A process of preparing an acid addition salt of delta-aminolevulinic acid comprising: dissolving a lower alkyl 5-bromolevulinate and an alkali metal diformylamide in an organic solvent selected from the group consisting of acetonitrile, methanol, tetrahydrofuran, 2-methyltetrahydrofuran and methylformate or mixtures thereof to form a suspension of an alkyl 5-(N,N-diformylamino) levulinate ester; and hydrolyzing said alkyl 5-(N,N-diformylamino) levulinate with an inorganic acid to form an acid addition salt of delta-amino levulinic acid.

Moens, Luc (Lakewood, CO)

1999-01-01T23:59:59.000Z

457

ARM - Lesson Plans: Acid Rain  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc Documentation RUC : XDCResearch Related InformationAcid Rain Outreach Home Room News

458

External Research Funding Agreements  

E-Print Network [OSTI]

1 External Research Funding Agreements University Policy No: RH8200 Classification: Research and university employees under Research Funding Agreements. DEFINITIONS 2.00 Research Funding Agreement means funding provided through an agreement with the university to be used for research purposes, whether

Victoria, University of

459

Forest Research: Climate Change  

E-Print Network [OSTI]

Forest Research: Climate Change projects Forest Research is part of the Forestry Commission of climate change-related research is wide-ranging, covering impact assessment and monitoring, adaptation around a quarter of its research budget with Forest Research on climate change and related programmes

460

Transforming Health Research  

E-Print Network [OSTI]

Transforming Health Research the first two years National Institute for Health Research Progress For Information R OCR R ef: 0 Gateway R ef: 9298 Title Transforming Health Research the first two years. Health Institute for Health Research Progress Report i Transforming Health Research the first two years National

Diggle, Peter J.

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Thermal Stability Of Formohydroxamic Acid  

SciTech Connect (OSTI)

The thermal stability of formohydroxamic acid (FHA) was evaluated to address the potential for exothermic decomposition during storage and its use in the uranium extraction process. Accelerating rate calorimetry showed rapid decomposition at a temperature above 65 {degree}?C; although, the rate of pressure rise was greater than two orders of magnitude less than the lower bound for materials which have no explosive properties with respect to transportation. FHA solutions in water and nitric acid did not reach runaway conditions until 150 {degree}?C. Analysis by differential scanning calorimetry showed that FHA melted at 67 {degree}?C and thermally decomposed at 90 {degree}?C with an enthalpy of -1924 J/g. The energics of the FHA thermal decomposition are comparable to those measured for aqueous solutions of hydroxylamine nitrate. Solid FHA should be stored in a location where the temperature does not exceed 20-25 {degree}?C. As a best practice, the solid material should be stored in a climate-controlled environment such as a refrigerator or freezer. FHA solutions in water are not susceptible to degradation by acid hydrolysis and are the preferred way to handle FHA prior to use.

Fondeur, F. F.; Rudisill, T. S.

2011-10-21T23:59:59.000Z

462

CHAPTER 13. ACID RAIN Acid rain was discovered in the 19th century by Robert Angus  

E-Print Network [OSTI]

247 CHAPTER 13. ACID RAIN Acid rain was discovered in the 19th century by Robert Angus Smith, a pharmacist from Manchester (England), who measured high levels of acidity in rain falling over industrial decline of fish populations in the lakes of southern Norway and traced the problem to acid rain. Similar

Jacob, Daniel J.

463

Fate of Acids in Clouds 1. Combination with bases dissolved in clouds: acids neutralized  

E-Print Network [OSTI]

problems. E#11;ects of Acid Rain 1. Vegetation: SO 2 is toxic to plants #15; Leaves damaged below pH 3 rain { Athens and Rome cathedrals and statues: pollution leads to acid rain #15; SteelFate of Acids in Clouds 1. Combination with bases dissolved in clouds: acids neutralized NH 3 (g

Schofield, Jeremy

464

Radioiodinated fatty acid analogs for myocardial imaging  

SciTech Connect (OSTI)

Fatty acids are the preferred substrate for the normoxic heart. About sixty percent of the energy required by the myocardium is provided by fatty acid [beta]-oxidation. Many scientists have focused on the alterations in fatty acid metabolism in the ischemic heart for the development of radiolabelled fatty acids for functional imaging of the heart. Three main categories of compounds were synthesized: tetrazoles (1 and 2), glycidic and [alpha]-methylene acids (3-5), and analogs of oleic acid (6,7 and 7A). The tetrazole group has a similar pKa and size to that of a carboxyl group; however, such fatty acid analogs cannot undergo normal fatty acid metabolism. Glycidic and [alpha]-methylene analogs are potential irreversible inhibitors of fatty acid metabolism. Oleic acid analogs were investigated to assess the affect of stereochemical consequences on biodistribution. The key intermediates in the synthesis of the target compounds were [omega]-nitrophenyl alkylcarboxylic acids and alcohols, which were made using a variety of cross-coupling reactions. The Wittig reaction, which was used in the synthesis of tetrazole 1 and glycidic acid 3, gave low yields of the cross-coupled products. The remaining target compounds were synthesized by condensation of appropriate RCu (CN) ZnI and substituted benzyl bromides or by Pd[sup II] catalyzed cross-coupling of substituted arylhalides with suitable alkynes. The latter two reactions produced much higher yields of the desired products. All of the target compounds were radiolabeled with [sup 125]I by various Cu(I) catalyzed radioiodine exchange procedures and were then subjected to tissue biodistribution (TD) studies in rats. Except for the 15-(4-iodophenyl)-2-methylene-pentadecanoic acid (5), all of the fatty acid analogs failed to surpass clinically-used 15-(4-iodophenyl)pentadecanoic acid (IPPA) in their ability to be taken up and retained by the rat myocardium.

Ruyan, M.K.

1993-01-01T23:59:59.000Z

465

INTERNATIONAL PACIFIC RESEARCH CENTER  

E-Print Network [OSTI]

INTERNATIONAL PACIFIC RESEARCH CENTER APRIL 2004­MARCH 2005 REPORT SCHOOL OF OCEAN AND EARTH RESEARCH HIGHLIGHTS Indo-Pacific Ocean Climate Pacific Research Center Design by: Susan Yamamoto Printed by: Hagadone Printing Company Photo: Waikiki

Wang, Yuqing

466

RESEARCH INFRASTRUCTURES Roadmap 2008  

E-Print Network [OSTI]

RESEARCH INFRASTRUCTURES FOR FRANCE Roadmap 2008 #12;INTRODUCTION European research infrastructures and development, benefiting to Europe's economy and competitiveness. This roadmap for the research infrastructures....................................................................................................6 3. The roadmap: existing and already decided RIs and others at the planning stage

Horn, David

467

BRAZIL RESEARCH INITIATIVES  

E-Print Network [OSTI]

Bioenergy Research Collaboration As a partner of the Great Lakes Bioenergy Research Center (GLBRC among agricultural researchers and stakeholders around the world. MSU's work with the GLBRC is organized

Liu, Taosheng

468

Integrated Particle Handling Methods for Multiplexed Microbial Identification and Characterization in Sediments and Groundwater  

SciTech Connect (OSTI)

Molecular methods are still relatively ineffectual for monitoring community dynamics during bioremediation, due primarily to the cost, technical difficulty and retrospective nature of the analyses. For nucleic acid analyses to meaningfully contribute to bioremediation efforts they must not only contribute to the fundamental understanding of microbial ecology, but also be formatted in such a manner that infield analysis can be achieved. The objective of this project is therefore to develop an integrated microbial and nucleic acid detection method and prototype system for the characterization and analysis of subsurface sediments, focusing on the molecular detection of metal and sulfate-reducing bacteria and activity in sediments obtained from the Oak Ridge Field Research Center. We are meeting this objective by combining environmental molecular microbiology with renewable surface techniques, microfluidic systems and microparticle analytical chemistry. The fluidic systems are used to evaluate hypotheses on the integrated biochemistry that is necessary to directly detect 16S rRNA from metal-reducing microbial communities on a suspension microarray, without using the polymerase chain reaction (PCR). These investigations include the use of peptide nucleic acid capture and detection probes and 'tunable surface' concepts to increase nucleic acid capture and detection efficiency and/or mitigate interferences due to co-extracted humic acids. The unified microparticle sample preparation method and suspension array is then used to characterize the 16S rRNA metal- and sulfate-reducing microbial community in FRC sediments before and after biostimulation.

Darrell P. Chandler; Ann E. Jarrell; Craig S. Criddle

2004-03-17T23:59:59.000Z

469

Solid phase sequencing of biopolymers  

DOE Patents [OSTI]

This invention relates to methods for detecting and sequencing target nucleic acid sequences, to mass modified nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probes comprise a single-stranded portion, an optional double-stranded portion and a variable sequence within the single-stranded portion. The molecular weights of the hybridized nucleic acids of the set can be determined by mass spectroscopy, and the sequence of the target determined from the molecular weights of the fragments. Nucleic acids whose sequences can be determined include DNA or RNA in biological samples such as patient biopsies and environmental samples. Probes may be fixed to a solid support such as a hybridization chip to facilitate automated molecular weight analysis and identification of the target sequence.

Cantor, Charles (Del Mar, CA); Koster, Hubert (La Jolla, CA)

2010-09-28T23:59:59.000Z

470

Micro-electro-mechanical systems phosphoric acid fuel cell  

DOE Patents [OSTI]

A phosphoric acid fuel cell system comprising a porous electrolyte support, a phosphoric acid electrolyte in the porous electrolyte support, a cathode electrode contacting the phosphoric acid electrolyte, and an anode electrode contacting the phosphoric acid electrolyte.

Sopchak, David A. (Livermore, CA); Morse, Jeffrey D. (Martinez, CA); Upadhye, Ravindra S. (Pleasanton, CA); Kotovsky, Jack (Oakland, CA); Graff, Robert T. (Modesto, CA)

2010-12-21T23:59:59.000Z

471

Micro-electro-mechanical systems phosphoric acid fuel cell  

DOE Patents [OSTI]

A phosphoric acid fuel cell system comprising a porous electrolyte support, a phosphoric acid electrolyte in the porous electrolyte support, a cathode electrode contacting the phosphoric acid electrolyte, and an anode electrode contacting the phosphoric acid electrolyte.

Sopchak, David A. (Livermore, CA); Morse, Jeffrey D. (Martinez, CA); Upadhye, Ravindra S. (Pleasanton, CA); Kotovsky, Jack (Oakland, CA); Graff, Robert T. (Modesto, CA)

2010-08-17T23:59:59.000Z

472

acid bacteria isolates: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

acids are solids not liquids. They sublime under vacuum to compare the strengths of solid acids with liquid acids therefore led us to obtain a measure of acidity in dilute...

473

acid bacteria isolated: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

acids are solids not liquids. They sublime under vacuum to compare the strengths of solid acids with liquid acids therefore led us to obtain a measure of acidity in dilute...

474

Research News TEMPLATE  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

(DOE) Methane Hydrates R&D Program is addressing myriad questions NETL researcher Kelly Rose evaluates a natural gas hydrate research core from India's NGHP-01 natural...

475

Operations Research Analyst  

Broader source: Energy.gov [DOE]

The incumbent in this position will serve as an Operations Research Analyst in the Generation Scheduling (PGS). The Operations Research Analyst is responsible for analytical work that involves...

476

Current Testbed Research  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Current Testbed Research Previous Testbed Research Proposal Process Terms and Conditions Dark Fiber Testbed Performance (perfSONAR) Software & Tools Development Partnerships...

477

JOURNAL OF GEOPHYSICAL RESEARCH, VOL. 105, NO. Dl, PAGES 1387-1415, JANUARY 20,2000 Sulfur chelllistry in the National Center for  

E-Print Network [OSTI]

Understanding the tropospheric sulfur cycle is impor- tant because of its contribution to acid rain and its effect on the Earth's radiation balance. The role of sulfuric acid in acid rain has been recognizedJOURNAL OF GEOPHYSICAL RESEARCH, VOL. 105, NO. Dl, PAGES 1387-1415, JANUARY 20,2000 Sulfur

Schwartz, Stephen E.

478

NREL Creates New Pathways for Producing Biofuels and Acids from Cyanobacteria (Fact Sheet)  

SciTech Connect (OSTI)

Cyanobacteria use photosynthesis to convert carbon dioxide into glycogen, a carbohydrate that is stored in the cells as an energy source. However, researchers at the National Renewable Energy Laboratory (NREL) have discovered that this photosynthesis can be redirected to produce lipids and valuable organic acids. The research could yield a new source of biofuels, because the lipids can potentially be extracted from the bacteria and converted into biodiesel.

Not Available

2012-10-01T23:59:59.000Z

479

Sandia National Laboratories: Research: Research Foundations...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

pulsed-power machine. The Radiation Effects and High Energy Density Science Research Foundation seeks to advance science and engineering in the areas of radiation effects sciences,...

480

Research at Research Development Services and  

E-Print Network [OSTI]

· $400M ongoing upgrade · FEL Light Source (~14kW) CEBAF #12;Alternative Energy ·Algal Biodiesel Research

Note: This page contains sample records for the topic "nucleic acids research" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Jahresbericht der Research Academy  

E-Print Network [OSTI]

Jahresbericht der Research Academy Leipzig 2008 #12;Inhalt Die Research Academy Leipzig 3 Vorwort Research Academy Leipzig im Aufwind 3 Die Arbeit der RAL-Doktorandenvertretung 2008 4 Fächerübergreifendes Qualifikationsprogramm Die Veranstaltungen der Research Academy Leipzig 2008 5 Seminar ,,Junge Wissenschaft und Praxis" 6

Schüler, Axel

482

Ultracomputer Research Project  

SciTech Connect (OSTI)

This document presents significant accomplishments made on the Ultracomputer Research Project during CY92.

Gottlieb, A.

1992-10-01T23:59:59.000Z

483

Research Councils UK Transforming  

E-Print Network [OSTI]

research is helping to accelerate the use of green energy technologies. RCUK has played a key role to help combat climate change, accelerate the deployment of green energy technologies and create newResearch Councils UK Transforming our energy future #12;Research funded by the Research Councils

Berzins, M.

484

Oleic AcidDependent Modulation of NITRIC OXIDE ASSOCIATED1 Protein Levels Regulates Nitric  

E-Print Network [OSTI]

of Agriculture­Agricultural Research Service, Washington State University, Prosser, Washington 99350 acid, which induces anti-inflammatory effects (Denys et al., 2001). FAs also serve as alarm molecules also regulate salt, drought, and heavy metal tolerance as well as wounding-induced responses

Kachroo, Pradeep

485

Research Roadmap Presentation  

E-Print Network [OSTI]

Research Roadmap Presentation: euCognition Meeting, Munich 12 Jan 2007 http://www.eucognition.org/six_monthly_meeting_2.htm What's a Research Roadmap For? Why do we need one? How can we produce one? Aaron Sloman ( http.cs.bham.ac.uk/research/projects/cosy/papers/#pr0701 See also the euCognition Research Roadmap project: http://www.eucognition.org/wiki/index.php?title=Research_Roadmap

Sloman, Aaron

486

Laboratory Directed Research & Development program. Annual report to the Department of Energy  

SciTech Connect (OSTI)

This report briefly discusses the following projects coordinated at Brookhaven National Laboratory: investigation of the utility of max-entropy methods for the analysis of powder diffraction data; analysis of structures and interactions of nucleic acids and proteins by small angle x-ray diffraction; relaxographic MRI and functional MRI; very low temperature infra-red laser absorption as a potential analytical tool; state-resolved measurements of H{sub 2} photodesorption: development of laser probes of H{sub 2} for in-situ accelerator measurements; Siberian snake prototype development for RHIC; synthesis and characterization of novel microporous solids; ozone depletion, chemistry and physics of stratospheric aerosols; understanding the molecular basis for the synthesis of plant fatty acids possessing unusual double bond positions; structure determination of outer surface proteins of the Lyme disease spirochete; low mass, low-cost multi-wire proportional chambers for muon systems of collider experiments; theory of self-organized criticality; development of the PCR-SSCP technique for the detection, at the single cell level, of specific genetic changes; feasibility of SPECT in imaging of F-18 FDG accumulation in tumors; visible free electron laser oscillator experiment; study of possible 2 + 2 TeV muon-muon collider; ultraviolet FEL R & D; precision machining using hard x-rays; new directions in in-vivo enzyme mapping: catechol-O-methyltransferase; proposal to develop a high rate muon polarimeter; development of intense, tunable 20-femtosecond laser systems; use of extreme thermophilic bacterium thermatoga maritima as a source of ribosomal components and translation factors for structural studies; and biochemical and structural studies of Chaperon proteins from thermophilic bacteria and other experiments.

Ogeka, G.J.; Romano, A.J.

1995-12-01T23:59:59.000Z

487

Sandia's research spans generation, storage, and load management at  

E-Print Network [OSTI]

Sandia's research spans generation, storage, and load management at the component and systems kW diesel genset, fuel cells, and additional interchangeable generators. Storage capabilities include a 500 kWh lead-acid battery bank, along with several additional batteries of smaller size. Over

488

Montana Water Resources Research Center Annual Technical Report  

E-Print Network [OSTI]

the potential to release significant levels of acidity, heavy metals, and toxic oxyanions (As) to groundwater Information Category Data Title Influence of Organic Mine Reclamation Amendments on Metal Mobility and Water Pollution Potential Project Number C-01 Start Date 09/01/1998 End Date 09/30/2000 Research Category Water

489

Testing of organic acids in engine coolants  

SciTech Connect (OSTI)

The effectiveness of 30 organic acids as inhibitors in engine coolants is reported. Tests include glassware corrosion of coupled and uncoupled metals. FORD galvanostatic and cyclic polarization electrochemistry for aluminum pitting, and reserve alkalinity (RA) measurements. Details of each test are discussed as well as some general conclusions. For example, benzoic acid inhibits coupled metals well but is ineffective on cast iron when uncoupled. In benzoic acid inhibits coupled metals well but is ineffective on cast iron when uncoupled. In general, the organic acids provide little RA when titrated to a pH of 5.5, titration to a pH of 4.5 can result in precipitation of the acid. Trends with respect to acid chain length are reported also.

Weir, T.W. [ARCO Chemical Co., Newtown Square, PA (United States)

1999-08-01T23:59:59.000Z

490

Carboxylic acid accelerated formation of diesters  

DOE Patents [OSTI]

This invention pertains to accelerating the rate of formation of 1,1-dicarboxylic esters from the reaction of an aldehyde with a carboxylic acid anhydride or a ketene in the presence of a non-iodide containing a strong Bronsted acid catalyst by the addition of a carboxylic acid at about one bar pressure and between about 0 and 80 C in the substantial absence of a hydrogenation or carbonylation catalyst.

Tustin, G.C.; Dickson, T.J.

1998-04-28T23:59:59.000Z

491

Organic Phosphoric Acid of the Soil.  

E-Print Network [OSTI]

TEXAS AGRICULTURAL EXPERIMENT STATIONS BULLETIN NO. +6CT /36 CHEMICAL SECTION, FEBRUARY, 191 1 I TECHNICAL BULLETIN Organic Phosphoric Acid of the Soil BY G. S. FRAPS, Chemist POSTOFFICE College Station, Brazos County, 'Texas. ,\\ustin... . ................................................ introduction 5 .............................. hmmonia-Soluble Phosphoric Acid 5 ................ Solubility of Phosphates in Ammonia 6 I Fixation of Phosphoric Acid from Ammonia .......... 7 Effect of Ratio of Soil to Solvent in Extraction of Phos- I I...

Fraps, G. S. (George Stronach)

1911-01-01T23:59:59.000Z

492

Carboxylic acid accelerated formation of diesters  

DOE Patents [OSTI]

This invention pertains to accelerating the rate of formation of 1,1-dicarboxylic esters from the reaction of an aldehyde with a carboxylic acid anhydride or a ketene in the presence of a non-iodide containing a strong Bronsted acid catalyst by the addition of a carboxylic acid at about one bar pressure and between about 0.degree. and 80.degree. C. in the substantial absence of a hydrogenation or carbonylation catalyst.

Tustin, Gerald Charles (Kingsport, TN); Dickson, Todd Jay (Kingsport, TN)

1998-01-01T23:59:59.000Z

493

Novel Regenerated Solvent Extraction Processes for the Recovery of Carboxylic Acids or Ammonia from Aqueous Solutions Part I. Regeneration of Amine-Carboxylic Acid Extracts  

E-Print Network [OSTI]

production of citric acid by fermentation, recovery of theof Citric Acid from Aqueous Fermentation Solutions byof citric acid was 1.1.1 Lactic Acid Currently, fermentation

Poole, L.J.

2008-01-01T23:59:59.000Z

494

Acid Doped Membranes for High Temperature PEMFC  

Broader source: Energy.gov [DOE]

Presentation on Acid Doped Membranes for High Temperature PEMFC to the High Temperature Membrane Working Group, May 25, 2004 in Philadelphia, PA.

495

Organic acid-tolerant microorganisms and uses thereof for producing organic acids  

DOE Patents [OSTI]

Organic acid-tolerant microorganisms and methods of using same. The organic acid-tolerant microorganisms comprise modifications that reduce or ablate AcsA activity or AcsA homolog activity. The modifications increase tolerance of the microorganisms to such organic acids as 3-hydroxypropionic acid (3HP), acrylic acid, and propionic acid. Further modifications to the microorganisms such as increasing expression of malonyl-CoA reductase and/or acetyl-CoA carboxylase provide or increase the ability of the microorganisms to produce 3HP. Methods of generating an organic acid with the modified microorganisms are provided. Methods of using acsA or homologs thereof as counter-selectable markers include replacing acsA or homologs thereof in cells with genes of interest and selecting for the cells comprising the genes of interest with amounts of organic acids effective to inhibit growth of cells harboring acsA or the homologs.

Pfleger, Brian Frederick; Begemann, Matthew Brett

2014-05-06T23:59:59.000Z

496

E-Print Network 3.0 - acid eicosapentaenoic acid Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: acid eicosapentaenoic acid Page: << < 1 2 3 4 5 > >> 1 Fish or Fish Oil in the Diet and Heart Attacks MAURICE E. STANSBY Summary: . Further...

497

E-Print Network 3.0 - acids eicosapentaenoic acid Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: acids eicosapentaenoic acid Page: << < 1 2 3 4 5 > >> 1 Fish or Fish Oil in the Diet and Heart Attacks MAURICE E. STANSBY Summary: . Further...

498

2006 DOE Hydrogen Program Poly (p-phenylene Sulfonic Acid)s with...  

Broader source: Energy.gov (indexed) [DOE]

2006 DOE Hydrogen Program Poly (p-phenylene Sulfonic Acid)s with Frozen-in Free Volume for use in High Temperature Fuel Cells 2006 DOE Hydrogen Program Poly (p-phenylene Sulfonic...

499

2006 DOE Hydrogen Program Poly (p-phenylene Sulfonic Acid)s with...  

Broader source: Energy.gov (indexed) [DOE]

Poly(p-phenylene Sulfonic Acid)s with Frozen-in Free Volume for use in High Temperature Fuel Cells Morton Litt and Peter Pintauro Case Western Reserve University Cleveland, Ohio...

500

Decomposition Studies of Triphenylboron, Diphenylborinic Acid and Phenylboric Acid in Aqueous Alkaline Solutions Containing Copper  

SciTech Connect (OSTI)

This report documents the copper-catalyzed chemical kinetics of triphenylboron, diphenylborinic acid and phenylboric acid (3PB, 2PB and PBA) in aqueous alkaline solution contained in carbon-steel vessels between 40 and 70 degrees C.

Crawford, C.L. [Westinghouse Savannah River Company, AIKEN, SC (United States); Peterson, R. A.

1997-02-11T23:59:59.000Z