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1

The REMOTE SENSlNf  

Office of Legacy Management (LM)

REMOTE REMOTE SENSlNf ' . 1 ARllRllRRv OF THE UNITED STATES DEPARTMENT OF ENERGY . . . . .a. * ~~&hrEAWWMms Gap ~~&hrEAwwMms Gap ECT FOLLdW-UP REPORT ECT FOLLdW-UP REPORT NOVEMBER 1979 NOVEMBER 1979 AN AERIAL RADIOLOGICAL SURVEY OF THE CURTIS BAY FACILITY OF THE W. FL GRACE COMPANY Baltimore, Maryland t. Kent Hilton Project Scientist APPROVED FORPUBLlCATlON ' : T. P. Stuart, Manager Remote Sensing Sciences Department ATTACHMENT 4- ECT Follow-Up Report AN AERIAL RADIOLOGICAL SURVEY OF THE CURTIS BAY FACILITY This is the second of two reports discussing the gamma ray radiation levels measured at the Curtis Bay facility of the W. R. Grace Company. The first report presented gross count contours and gamma ray spectra over the most active areas. Refined gross count isopleth maps will be

2

Molecular Cell XIAP Induces NF-kB Activation  

E-Print Network (OSTI)

Molecular Cell Article XIAP Induces NF-kB Activation via the BIR1/TAB1 Interaction and BIR1 NF-kB and MAP kinase activation during TGF-b and BMP receptor signaling and upon overexpression. Here with TAB1 to induce NF-kB activation. TAB1 is an upstream adaptor for the activation of the kinase TAK1

Wu, Hao

3

NF kappa B expression and matrix metalloproteinase activity in hypertension  

E-Print Network (OSTI)

299-306, 1995. Baldwin A.S. The NF-kB and IkB Proteins: Newof transcription factor NF-kB in mouse glomerular mesangialwere then labeled with anti-NF-kB p65 rabbit polyclonal

Wu, Kwan-I

2009-01-01T23:59:59.000Z

4

Cloning and expression of equine NF-kB2  

E-Print Network (OSTI)

Equine infectious anemia virus (EIAV) is a macrophage-tropic retrovirus that causes persistent disease in horses and ponies. In addition to its structural proteins, EIAV encodes four regulatory/accessory genes, tat, rev, ttm, and S2. It has been documented EIAV S2 gene expression is essential for disease expression of EIAV. Using a yeast two-hybrid assay, it was shown that S2 protein interacts with human NF-KB2. NF-KB2 plays a key role in the alternative or non-canonical NF-KB pathway. In order to determine if the interaction of S2 with NF-KB2 might be relevant to equine disease, a cDNA representing full length equine NF-KB2 was generated in our laboratory using PCR and rapid amplification of cDNA ends. To our knowledge this is the first time that equine NF-KB2 cDNAs have been recovered and characterized. The sequence of equine NF-KB2 was 95% homologous to human overall, however a major difference was found in the ankyrin repeat region where protein-protein interactions occur. Two splice variants of equine NF-KB2 were found that correspond to splice variants of human NF- KB2. We tested the interaction of EIAV S2 and equine NF-KB2 using the yeast two hybrid system (Y2H) and co-immunoprecipitation. Unfortunately we were not able to detect an interaction between EIAV S2 and equine NF-KB2 in either system. Despite this result, NF-KB2 is an important component in the immune response so we examined its expression in equine macrophages. Moreover we were interested to know if EIAV might affect expression levels of equine NF-KB2, as NF-KB2 is a target of other viruses. Hence, the expression level of equine NF-KB2 was measured in uninfected and infected primary equine monocyte- derived macrophage (eMDM). Using quantitative PCR we determined that equine NF-KB2 gene expression is decreased in eMDM after 3 days post plating, about the time that monocytes start to differentiate into mature macrophages. However EIAV infection of eMDM upregulated the expression level of NF-KB2.

Mirhosseini, Negin

2008-05-01T23:59:59.000Z

5

CMRR-NF SEIS Scoping Information | National Nuclear Security...  

National Nuclear Security Administration (NNSA)

OctoberNovember 2010 Scoping meeting posters Welcome How You Can Submit Your Comments LANL Technical Areas Chemistry and Metallurgy Research Replacement (CMRR) CMRR-NF SEIS...

6

A NF-kappaB temporal code to ensure specificity in inflammatory signaling  

E-Print Network (OSTI)

requires the interaction of NF-kB with other transcriptionD. 2006. Circuitry of NF-kB Signaling. Immunological Reviewscontrol the dynamics of NF-kB signaling and gene expression.

Werner, Shannon L.

2009-01-01T23:59:59.000Z

7

Quantitative characterization and analysis of the dynamic NF-kappaB response in microglia  

E-Print Network (OSTI)

J, Wirth T, Schwaninger M: NF- kB is activated and promotesdomains of A20 downregulate NF-kB signalling. Nature 2004,Levchenko A: Understanding NF-kB signaling via mathematical

Sheppard, Patrick W; Sun, Xiaoyun; Emery, John F; Giffard, Rona G; Khammash, Mustafa

2011-01-01T23:59:59.000Z

8

Temporal encoding and homeostatic control in the IKK- kappaNF-kappaB signaling system  

E-Print Network (OSTI)

to control constitutive NF-kB activity." Molecular SystemsPharmacological Inhibitors on NF-kB Activation TimecoursesPharmacological Inhibitors on NF-kB Activation 102 x

Barken, Derren

2007-01-01T23:59:59.000Z

9

Homeostatic control of IkappaB metabolism determines NF- kappaB responsiveness  

E-Print Network (OSTI)

A. , and Ghosh, G. 2007. NF-kB dictates IkB degradationI?B protein within the NF-kB signaling module. Cell. 128:

O'Dea, Ellen Louise

2010-01-01T23:59:59.000Z

10

Modulation of the NF-kB Pathway by Bordetella  

E-Print Network (OSTI)

Background: Filamentous hemagglutinin (FHA) is a cell-associated and secreted adhesin produced by Bordetella pertussis with pro-apoptotic and pro-inflammatory activity in host cells. Given the importance of the NF-kB transcription factor family in these host cell responses, we examined the effect of FHA on NF-kB activation in macrophages and bronchial epithelial cells, both of which are relevant cell types during natural infection. Methodology/Principal Findings: Exposure to FHA of primary human monocytes and transformed U-937 macrophages, but not BEAS-2B epithelial cells, resulted in early activation of the NF-kB pathway, as manifested by the degradation of cytosolic IkBa, by NF-kB DNA binding, and by the subsequent secretion of NF-kB-regulated inflammatory cytokines. However, exposure of macrophages and human monocytes to FHA for two hours or more resulted in the accumulation of cytosolic IkBa, and the failure of TNF-a to activate NF-kB. Proteasome activity was attenuated following exposure of cells to FHA for 2 hours, as was the nuclear translocation of RelA in BEAS-2B cells. Conclusions: These results reveal a complex temporal dynamic, and suggest that despite short term effects to the contrary, longer exposures of host cells to this secreted adhesin may block NF-kB activation, and perhaps lead to a compromised immune response to this bacterial pathogen.

Pertussis Filamentous Hemagglutinin; Tzvia Abramson; Hassya Kedem; David A. Relman

2008-01-01T23:59:59.000Z

11

Kinetics of NF-kB nucleocytoplasmic transport probed by single-cell screening without imaging  

E-Print Network (OSTI)

Kinetics of NF-kB nucleocytoplasmic transport probed by single-cell screening without imaging Jun of nucleocytoplasmic transport of an important transcription factor NF-kB. With data collected from single cells, we activation barrier for NF-kB transport. Our data demonstrate that NF-kB nucleocytoplasmic transport fits

Lu, Chang

12

Charting the NF-kB Pathway Interactome Map  

E-Print Network (OSTI)

Inflammation is part of a complex physiological response to harmful stimuli and pathogenic stress. The five components of the Nuclear Factor kB (NF-kB) family are prominent mediators of inflammation, acting as key transcriptional regulators of hundreds of genes. Several signaling pathways activated by diverse stimuli converge on NF-kB activation, resulting in a regulatory system characterized by high complexity. It is increasingly recognized that the number of components that impinges upon phenotypic outcomes of signal transduction pathways may be higher than those taken into consideration from canonical pathway representations. Scope of the present analysis is to provide a wider, systemic picture of the NF-kB signaling system. Data from different sources such as literature, functional enrichment web resources, protein-protein interaction and pathway databases have been gathered, curated, integrated and analyzed in order to reconstruct a single, comprehensive picture of the proteins that interact with, and participate to the NF-kB activation system. Such a reconstruction shows that the NF-kB interactome is substantially different in quantity and quality of components with respect to canonical representations. The analysis highlights that several neglected but topologically central proteins may play a role in the activation of NF-kB mediated responses. Moreover the interactome structure fits with the characteristics of a bow tie architecture. This interactome is intended as an open network resource available for further development,

Paolo Tieri; Alberto Termanini; Elena Bellavista; Stefano Salvioli; Miriam Capri

2011-01-01T23:59:59.000Z

13

NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function  

SciTech Connect

NF45/ILF2 associates with NF90/ILF3 in the nucleus and regulates IL-2 gene transcription at the antigen receptor response element (ARRE)/NF-AT DNA target sequence (P.N. Kao, L. Chen, G. Brock, J. Ng, A.J. Smith, B. Corthesy, J. Biol. Chem. 269 (1994) 20691-20699). NF45 is widely expressed in normal tissues, especially testis, brain, and kidney, with a predominantly nuclear distribution. NF45 mRNA expression is increased in lymphoma and leukemia cell lines. The human and murine NF45 proteins differ only by substitution of valine by isoleucine at amino acid 142. Fluorescence in situ hybridization localized the human NF45 gene to chromosome 1q21.3, and mouse NF45 gene to chromosome 3F1. Promoter analysis of 2.5 kB of the murine NF45 gene reveals that significant activation is conferred by factors, possible including NF-Y, that bind to the CCAAT-box sequence. The function of human NF45 in regulating IL-2 gene expression was characterized in Jurkat T-cells stably transfected with plasmids directing expression of NF45 cDNA in sense or antisense orientations. NF45 sense expression increased IL-2 luciferase reporter gene activity 120-fold, and IL-2 protein expression 2-fold compared to control cells. NF45 is a highly conserved, regulated transcriptional activator, and one target gene is IL-2.

Zhao Guohua [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States); Shi Lingfang [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States); Qiu Daoming [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States); Hu Hong [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States); Kao, Peter N. [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States)]. E-mail: peterkao@stanford.edu

2005-05-01T23:59:59.000Z

14

Transcriptional regulation of antimicrobial peptide induction by NF-[kappa]B family members during the Drosophila melanogaster immune response  

E-Print Network (OSTI)

Dl), a member of the NF-kB family, through degradation ofworks in conjunction with NF-kB members to regulate fat bodystandard deviation. (C). Role of fly NF-kB proteins in AttA

Busse, Matthew Schmidt

2007-01-01T23:59:59.000Z

15

Mathematical model of NF-kB regulatory module  

E-Print Network (OSTI)

The two-feedback-loop regulatory module of nuclear factor kB (NF-kB) signaling pathway is modeled by means of ordinary differential equations. The constructed model involves two-compartment kinetics of the activators IkB (IKK) and NF-kB; the inhibitors A20 and IkBa; and their complexes. In resting cells, the unphosphorylated IkBa binds to NF-kB and sequesters it in an inactive form in the cytoplasm. In response to extracellular signals such as tumor necrosis factor or interleukin-1, IKK is transformed from its neutral form (IKKn) into its active form (IKKa), a form capable of phosphorylating IkBa; leading to IkBa degradation. Degradation of IkBa releases the main activator NF-kB; which then enters the nucleus and triggers transcription of the inhibitors and numerous other genes. The newly synthesized IkBa leads NF-kB out of the nucleus and sequesters it in the cytoplasm, while A20 inhibits IKK converting IKKa into the inactive form (IKKi), a form different from IKKn, no longer capable of phosphorylating IkBa: After parameter fitting, the proposed model is able to properly reproduce time behavior of all variables for which the data are available: NF-kB; cytoplasmic IkBa; A20 and IkBa mRNA transcripts, IKK and IKK catalytic activity in both wild-type and A20-deficient cells. The model allows detailed analysis of kinetics of the involved proteins and their complexes and gives the predictions of the possible responses of whole kinetics to the change in the level of a given activator or inhibitor.

Tomasz Lipniacki A; Pawel Paszek B; Allan R. Brasier D; Bruce Luxon C; Marek Kimmel B

2003-01-01T23:59:59.000Z

16

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1  

E-Print Network (OSTI)

super family pathway and NF-kB pathway, such as TRADD, RELB,genes from wound healing and NF-kB signaling. Samples in the

Verhaak, Roel GW

2010-01-01T23:59:59.000Z

17

Physiological functions for brain NF-kB Mollie K. Meffert and David Baltimore  

E-Print Network (OSTI)

Physiological functions for brain NF-kB Mollie K. Meffert and David Baltimore Division of BiologyB (NF-kB) family of transcription factors are activated within the CNS in pathological settings of the mechanisms of Ca2C -responsive activation and synaptic signaling to the nucleus by NF-kB transcription

Baltimore, David

18

Single-cell NF-kB dynamics reveal digital activation and analogue information processing  

E-Print Network (OSTI)

LETTERS Single-cell NF-kB dynamics reveal digital activation and analogue information processing information to the gene expression programs by means of the transcription factor nuclear factor (NF)-kB. We measured NF-kB activity in thousands of live cells under TNF-a doses covering four orders of magnitude. We

Quake, Stephen R.

19

ORIGINAL ARTICLE NF-jB activation by combinations of NEMO SUMOylation and ATM  

E-Print Network (OSTI)

The Rel/NF-kB family of transcription factors has been intensively studied as an important paradigm expression profiles (reviewed in Hayden and Ghosh (2004)). The proto- typical mammalian NF-kB complex, a p50 necrosis factor (TNF), interleukin-1 and bacterial lipopolysaccharide (LPS), activate NF-kB via convergence

Miyamoto, Shigeki

20

Dual Delayed Feedback Provides Sensitivity and Robustness to the NF-kB Signaling Module  

E-Print Network (OSTI)

Dual Delayed Feedback Provides Sensitivity and Robustness to the NF-kB Signaling Module Diane M of the transcription factor NF-kB. Linear stability analysis of the model shows that oscillatory frequency is a hard system minimizes stochastic excursions of the output to produce a robust NF-kB response. Citation: Longo

Hasty, Jeff

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

NF-[kappa]B RelB/p52 heterodimer : biogenesis and DNA recognition  

E-Print Network (OSTI)

A fourth IkB protein in the NF-kB signaling module. Cell, InCD28 is mediated through an NF-kB-like response element. JTo further test how other NF-kB dimers interact with CREB,

Fusco, Amanda J.

2007-01-01T23:59:59.000Z

22

Vol. 2003, Issue 36, pp. nf17, 10 September 2003 [DOI: 10.1126/sageke.2003.36.nf17  

E-Print Network (OSTI)

Document URL: http://sageke.sciencemag.org/cgi/content/full/sageke;2003/36/nf17 Science , . This article sophomore year in 1987. "It was actually a science experiment gone awry," confesses Gazzaley with a giggle into the toilet bowl. But he had miscalculated the power of the reaction: The resulting explosion shook

23

b-Arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-jB  

E-Print Network (OSTI)

: b-arrestin2; CK2; NF-kB Introduction The UV response in mammalian cells is mediated through activation of several transcription factors, including NF-kB (Shaulian et al, 2000). In resting cells, NF-kB by Silverman and Maniatis, 2001). The binding of IkB to NF-kB masks the nuclear localization sequences (NLS

Tian, Weidong

24

COMMD1 promotes the ubiquitination of NF-jB subunits through a cullin-containing ubiquitin  

E-Print Network (OSTI)

& transcription; proteins Keywords: COMMD1; cullin; NF-kB; transcription; ubiquitination Introduction NF-kB im- munity, apoptosis, and cell cycle progression (Karin and Lin, 2002). In mammals, NF-kB subunits into the mature p50 and p52 subunits, respectively. NF-kB is ordinarily sequestered in the cytoplasm

Burstein, Ezra

25

NF-kB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1a  

E-Print Network (OSTI)

LETTERS NF-kB links innate immunity to the hypoxic response through transcriptional regulation, regulated by several transcription factors, among which NF-kB plays a central role5,6 . NF-kB activation between NF-kB and HIF-1a has proven elusive. Using in vitro systems, it was reported that HIF-1a activates

Nizet, Victor

26

Low Dose Radiation Research Program: Regulation of NF-kB and MnSOD in Low  

NLE Websites -- All DOE Office Websites (Extended Search)

NF-kB and MnSOD in Low Dose Radiation-Induced Adaptive NF-kB and MnSOD in Low Dose Radiation-Induced Adaptive Responses in Mouse and Human Skin Cells Jian Jian Li School of Health Sciences, Purdue University West Lafayette, Indiana Why this Project? To determine if low dose ionizing radiation-induced adaptive responses in skin cells are mediated by activation of signaling networks. Project Goals To evaluate the signaling networks involving transcription factor NF-kB and the mitochondrial antioxidant protein MnSOD. To determine if NF-kB is activated by low dose radiation in vivo. To determine if NF-kB activation is critical in the pathways that produce adaptive responses. Experimental Approach Cells transfected with NF-kB luciferase responder genes will be used to define a dose-response relationship for activation of the NF-kB gene. NF-kB

27

The IkBa/NF-kB complex has two hot spots, one at either end of the interface  

E-Print Network (OSTI)

The IkBa/NF-kB complex has two hot spots, one at either end of the interface SIMON BERGQVIST,1 of NF-kB family members via its ankyrin repeat (AR) domain. The binding affinity of IkBa with NF-kB(p50/p65) heterodimers and NF-kB(p65/65) homodimers is in the picomolar range, and in the cell

Komives, Elizabeth A.

28

Myelin Activates FAK/Akt/NF-kB Pathways and Provokes CR3-Dependent Inflammatory Response in Murine  

E-Print Network (OSTI)

Myelin Activates FAK/Akt/NF-kB Pathways and Provokes CR3-Dependent Inflammatory Response in Murine is through activation of FAK/PI3K/Akt/NF-kB signaling pathways and CR3 contributes to myelin-induced PI3K/Akt/NF-kB) are not able to activate NF-kB signaling pathway. In conclusion, our results demonstrate a crucial role

Fan, Jianqing

29

An Epigenetic Switch Involving NF-kB, Lin28, Let-7 MicroRNA, and IL6 Links  

E-Print Network (OSTI)

An Epigenetic Switch Involving NF-kB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell to cancer, and NF-kB appears to play a causa- tive role, but the mechanisms are poorly understood. We show activation triggers an inflammatory response mediated by NF-kB that directly activates Lin28 transcription

30

NMR studies of the transcriptional inhibitor I kappa B alpha and its interaction with the transcription factor NF kappa B  

E-Print Network (OSTI)

E. A. (2008) The IkBa/NF-kB complex has two hot-spots, oneThe genes regulated by NF-kB fall into various functionaldimerization domains and NF-kB p65 amino-terminal domain (

Cervantes, Carla F.

2010-01-01T23:59:59.000Z

31

Dying for NF-jB? Control of cell death by transcriptional regulation of the apoptotic machinery  

E-Print Network (OSTI)

Ezra Burstein and Colin S Duckett? The transcription factor nuclear factor kB (NF-kB) is a pleiotropic signals and cellular stress. Several hundred cellular genes have been shown to be regulated by NF-kB showed that loss or suppression of NF-kB results in an enhanced sensitivity to apoptosis. In the ensuing

Burstein, Ezra

32

WntD is a feedback inhibitor of Dorsal/NF-kB in Drosophila development and immunity  

E-Print Network (OSTI)

WntD is a feedback inhibitor of Dorsal/NF-kB in Drosophila development and immunity Michael D. Gordon1 , Marc S. Dionne2 , David S. Schneider2 & Roel Nusse1 Regulating the nuclear factor-kB (NF-kB melanogaster have proved fruitful in determining the signals used to control NF-kB proteins, beginning

Bejerano, Gill

33

NF-{kappa}B regulates Lef1 gene expression in chondrocytes  

SciTech Connect

The relation of Wnt/{beta}-catenin signaling to osteoarthritis progression has been revealed with little information on the underlying molecular mechanism. In this study we found overexpression of Lef1 in cartilage tissue of osteoarthritic patients and elucidated molecular mechanism of NF-{kappa}B-mediated Lef1 gene regulation in chondrocytes. Treatment of IL-1{beta} augmented Lef1 upregulation and nuclear translocation of NF-{kappa}B in chondrocytes. Under IL-1{beta} signaling, treatment of NF-{kappa}B nuclear translocation inhibitor SN-50 reduced Lef1 expression. A conserved NF-{kappa}B-binding site between mouse and human was selected through bioinformatic analysis and mapped at the 14 kb upstream of Lef1 transcription initiation site. NF-{kappa}B binding to the site was confirmed by chromatin immunoprecipitation assay. Lef1 expression was synergistically upregulated by interactions of NF-{kappa}B with Lef1/{beta}-catenin in chondrocytes. Our results suggest a pivotal role of NF-{kappa}B in Lef1 expression in arthritic chondrocytes or cartilage degeneration.

Yun, Kangsun [Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712 (Korea, Republic of); Choi, Yoo Duk [Department of Pathology, Chonnam National University Medical School, Gwangju 501-749 (Korea, Republic of); Nam, Jong Hee [Department of Pathology, Chonnam National University Medical School, Gwangju 501-749 (Korea, Republic of); Park, Zeeyoung [Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712 (Korea, Republic of); Im, Sin-Hyeog [Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712 (Korea, Republic of)]. E-mail: imsh@gist.ac.kr

2007-06-08T23:59:59.000Z

34

La activacin de NF-kB, indicador de recada en el cncer de mama  

E-Print Network (OSTI)

La activación de NF-kB, indicador de recaída en el cáncer de mama La ausencia de la proteína 14 proteico relacio- nado con la progresión tumoral, NF-kB, según apunta un estudio en PLoS ONE realiza- do activación de NF-kB en los tumores como el mejor indi- cador de recaída en las pa- cientes de cáncer de mama

Foissac, Sylvain

35

Optineurin Is Required for CYLD-Dependent Inhibition of TNFa-Induced NF-kB Activation  

E-Print Network (OSTI)

The nuclear factor kappa B (NF-kB) regulates genes that function in diverse cellular processes like inflammation, immunity and cell survival. The activation of NF-kB is tightly controlled and the deubiquitinase CYLD has emerged as a key negative regulator of NF-kB signalling. Optineurin, mutated in certain glaucomas and amyotrophic lateral sclerosis, is also a negative regulator of NF-kB activation. It competes with NEMO (NF-kB essential modulator) for binding to ubiquitinated RIP (receptor interacting protein) to prevent NF-kB activation. Recently we identified CYLD as optineurin-interacting protein. Here we have analysed the functional significance of interaction of optineurin with CYLD. Our results show that a glaucomaassociated mutant of optineurin, H486R, is altered in its interaction with CYLD. Unlike wild-type optineurin, the H486R mutant did not inhibit tumour necrosis factor a (TNFa)-induced NF-kB activation. CYLD mediated inhibition of TNFainduced NF-kB activation was abrogated by expression of the H486R mutant. Upon knockdown of optineurin, CYLD was unable to inhibit TNFa-induced NF-kB activation and showed drastically reduced interaction with ubiquitinated RIP. The level of ubiquitinated RIP was increased in optineurin knockdown cells. Deubiquitination of RIP by over-expressed CYLD was abrogated in optineurin knockdown cells. These results suggest that optineurin regulates NF-kB activation by mediating

Ananthamurthy Nagabhushana; Megha Bansal; Ghanshyam Swarup

2010-01-01T23:59:59.000Z

36

Imaging Pulmonary NF-kappaB Activation and Therapeutic Effects of MLN120B and TDZD-8  

E-Print Network (OSTI)

NF-kB activation is a critical signaling event in the inflammatory response and has been implicated in a number of pathological lung diseases. To enable the assessment of NF-kB activity in the lungs, we transfected a luciferase based NF-kB reporter into the lungs of mice or into Raw264.7 cells in culture. The transfected mice showed specific luciferase expression in the pulmonary tissues. Using these mouse models, we studied the kinetics of NF-kB activation following exposure to lipopolysaccharide (LPS). The Raw264.7 cells expressed a dose-dependent increase in luciferase following exposure to LPS and the NF-kB reporter mice expressed luciferase in the lungs following LPS challenge, establishing that bioluminescence imaging provides adequate sensitivity for tracking the NF-kB activation pathway. Interventions affecting the NF-kB pathway are promising clinical therapeutics, thus we further examined the effect of IKK-2 inhibition by MLN120B and glycogen synthase kinase 3 beta inhibition by TDZD-8 on NF-kB activation. Pre-treatment with either MLN120B or TDZD-8 attenuated NF-kB activation in the pulmonary tissues, which was accompanied with suppression of pro-inflammatory chemokine MIP-1 and induction of anti-inflammatory cytokine IL-10. In summary, we have established an imaging based approach for noninvasive and longitudinal assessment of NF-kB activation and regulation during acute lung injury. This approach will

Dan Ansaldi; Eldad A. Hod; Fabio Stellari; Jae-beom Kim; Mark Roskey; Kevin P. Francis; Rajendra Singh; Ning Zhang

2011-01-01T23:59:59.000Z

37

Polycystin-1 promotes PKC{alpha}-mediated NF-{kappa}B activation in kidney cells  

Science Conference Proceedings (OSTI)

Polycystin-1 (PC1), the PKD1 gene product, is a membrane receptor which regulates many cell functions, including cell proliferation and apoptosis, both typically increased in cyst lining cells in autosomal dominant polycystic kidney disease. Here we show that PC1 upregulates the NF-{kappa}B signalling pathway in kidney cells to prevent cell death. Human embryonic kidney cell lines (HEK293{sup CTT}), stably expressing a PC1 cytoplasmic terminal tail (CTT), presented increased NF-{kappa}B nuclear levels and NF-{kappa}B-mediated luciferase promoter activity. This, consistently, was reduced in HEK293 cells in which the endogenous PC1 was depleted by RNA interference. CTT-dependent NF-{kappa}B promoter activation was mediated by PKC{alpha} because it was blocked by its specific inhibitor Ro-320432. Furthermore, it was observed that apoptosis, which was increased in PC1-depleted cells, was reduced in HEK293{sup CTT} cells and in porcine kidney LtTA cells expressing a doxycycline-regulated CTT. Staurosporine, a PKC inhibitor, and parthenolide, a NF-{kappa}B inhibitor, significantly reduced the CTT-dependent antiapoptotic effect. These data reveal, therefore, a novel pathway by which polycystin-1 activates a PKC{alpha}-mediated NF-{kappa}B signalling and cell survival.

Banzi, Manuela [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy); Aguiari, Gianluca [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy); Trimi, Viky [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy); Mangolini, Alessandra [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy); Pinton, Paolo [General Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara (Italy); Witzgall, Ralph [Institute for Molecular and Cellular Anatomy, University of Regensburg, Regensburg (Germany); Rizzuto, Rosario [General Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara (Italy); Senno, Laura del [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy)]. E-mail: sen@unife.it

2006-11-17T23:59:59.000Z

38

MicroRNAs Modulate the Dynamics of the NF-kB Signaling Pathway  

E-Print Network (OSTI)

Background: NF-kB, a major transcription factor involved in mammalian inflammatory signaling, is primarily involved in regulation of response to inflammatory cytokines and pathogens. Its levels are tightly regulated since uncontrolled inflammatory response can cause serious diseases. Mathematical models have been useful in revealing the underlying mechanisms, the dynamics, and other aspects of regulation in NF-kB signaling. The recognition that miRNAs are important regulators of gene expression, and that a number of miRNAs target different components of the NF-kB network, motivate the incorporation of miRNA regulated steps in existing mathematical models to help understand the quantitative aspects of miRNA mediated regulation. Methodology/Principal findings: In this study, two separate scenarios of miRNA regulation within an existing model are considered. In the first, miRNAs target adaptor proteins involved in the synthesis of IKK that serves as the NF-kB activator. In the second, miRNAs target different isoforms of IkB that act as NF-kB inhibitors. Simulations are carried out under two different conditions: when all three isoforms of IkB are present (wild type), and when only one isoform (IkBa) is present (knockout type). In both scenarios, oscillations in the NF-kB levels are observed and are found to be dependent on the levels of miRNAs. Conclusions/Significance: Computational modeling can provide fresh insights into intricate regulatory processes. The

Ida Vaz; Arvind Singh Mer; Alok Bhattacharya; Ramakrishna Ramaswamy

2011-01-01T23:59:59.000Z

39

A test of first order scaling in Nf=2 QCD  

E-Print Network (OSTI)

We complete our analysis of Nf=2 QCD based on the lattice staggered fermion formulation. Using a series of Monte Carlo simulations at fixed (amq*Ls^yh) one is able to test the universality class with given critical exponent yh. This strategy has been used to test the O(4) universality class and it has been presented at the previous Lattice conferences. No agreement was found with simulations in the mass range amq=[0.01335,0.15] using lattices with Ls=16 up to 32 and Lt=4. With the same strategy, we now investigate the possibility of a first order transition using a new set of Monte Carlo data corresponding to yh=3 in the same mass and volume range as the one used for O(4). A substantial agreement is observed both in the specific heat scaling and in the scaling of the chiral condensate, while the chiral susceptibilities still presents visible deviation from scaling in the mass range explored.

G. Cossu; M. D'Elia; A. Di Giacomo; C. Pica

2007-09-30T23:59:59.000Z

40

The role of the phosphorus BIBII transition in proteinDNA recognition: the NF-kB complex  

E-Print Network (OSTI)

The role of the phosphorus BI±BII transition in protein±DNA recognition: the NF-kB complex K) containing the HIV-1 NF-kB-binding site, in which the sequences ¯anking the kB site had been mutated. 31P NMR of the BI±BII equilibrium in NF-kB recognition by DNA was then investigated by electrophoretic mobility

Paris-Sud XI, Université de

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Theoretical analyses predict A20 regulates period of NF-kB oscillation  

E-Print Network (OSTI)

The nuclear-cytoplasmic shuttling of NF-kB is characterized by damped oscillations of the nuclear concentration with a time period of around 1-2 hours. The NF-kB network contains several feedback loops modulating the overall response of NF-kB activity. While IkBa is known to drive and IkBe is known to dampen the oscillations, the precise role of A20 negative feedback remains to be elucidated. Here we propose a model of the NF-kB system focusing on three negative feedback loops (IkBa, IkBe and A20) which capture the experimentally observed responses in wild-type and knockout cells. We find that A20, like IkBe, efficiently dampens the oscillations albeit through a distinct mechanism. In addition, however, we have discovered a new functional role of A20 by which it controls the oscillation period of nuclear NF-kB. The design based on three nested feedback loops allows independent control of period and amplitude decay in the oscillatory response. Based on these results we predict that adjusting the expression lev...

Mengel, Benedicte; Jensen, Mogens H; Trusina, Ala

2009-01-01T23:59:59.000Z

42

Evolutionary Conserved Regulation of HIF-1b by NF-kB  

E-Print Network (OSTI)

Hypoxia Inducible Factor-1 (HIF-1) is essential for mammalian development and is the principal transcription factor activated by low oxygen tensions. HIF-a subunit quantities and their associated activity are regulated in a post-translational manner, through the concerted action of a class of enzymes called Prolyl Hydroxylases (PHDs) and Factor Inhibiting HIF (FIH) respectively. However, alternative modes of HIF-a regulation such as translation or transcription are under-investigated, and their importance has not been firmly established. Here, we demonstrate that NF-kB regulates the HIF pathway in a significant and evolutionary conserved manner. We demonstrate that NF-kB directly regulates HIF-1b mRNA and protein. In addition, we found that NF-kBmediated changes in HIF-1b result in modulation of HIF-2a protein. HIF-1b overexpression can rescue HIF-2a protein levels following NF-kB depletion. Significantly, NF-kB regulates HIF-1b (tango) and HIF-a (sima) levels and activity (Hph/fatiga, ImpL3/ldha) in Drosophila, both in normoxia and hypoxia, indicating an evolutionary conserved mode of regulation. These results reveal a novel mechanism of HIF regulation, with impact in the development of

Patrick Van Uden; Niall S. Kenneth; Ryan Webster; H. Arno Mller; Sharon Mudie; Sonia Rocha

2010-01-01T23:59:59.000Z

43

Endocytosis-Independent Function of Clathrin Heavy Chain in the Control of Basal NF-kB Activation  

E-Print Network (OSTI)

Background: Nuclear factor-kB (NF-kB) is a transcription factor that regulates the transcription of genes involved in a variety of biological processes, including innate and adaptive immunity, stress responses and cell proliferation. Constitutive or excessive NF-kB activity has been associated with inflammatory disorders and higher risk of cancer. In contrast to the mechanisms controlling inducible activation, the regulation of basal NF-kB activation is not well understood. Here we test whether clathrin heavy chain (CHC) contributes to the regulation of basal NF-kB activity in epithelial cells. Methodology: Using RNA interference to reduce endogenous CHC expression, we found that CHC is required to prevent constitutive activation of NF-kB and gene expression. Immunofluorescence staining showed constitutive nuclear localization of the NF-kB subunit p65 in absence of stimulation after CHC knockdown. Elevated basal p65 nuclear localization is caused by constitutive phosphorylation and degradation of inhibitor of NF-kB alpha (IkBa) through an IkB kinase a (IKKa)-dependent mechanism. The role of CHC in NF-kB signaling is functionally relevant as constitutive expression of the proinflammatory chemokine interleukin-8 (IL-8), whose expression is regulated by NF-kB, was found after CHC knockdown. Disruption of clathrin-mediated endocytosis by chemical inhibition or depletion of the m2-subunit of the endocytosis adaptor protein AP-2, and knockdown of clathrin light chain a (CHLa), failed to induce constitutive NF-kB activation and IL-8 expression, showing that CHC acts on NF-kB independently of endocytosis and CLCa.

Man Lyang Kim; Isabel Sorg; Ccile Arrieumerlou

2011-01-01T23:59:59.000Z

44

Investigating the role of intra- and extra-cellular modulators of the transcription factor NF-kappaB  

E-Print Network (OSTI)

The nuclear factor-kappa B (NF-kappaB) family of transcription factors play a pivotal role in the inflammatory and immune responses, as well as cell growth and survival. Since its discovery 25 years ago, NF-kappaB has ...

Nguyen, Hung Nhat

2011-01-01T23:59:59.000Z

45

Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells  

Science Conference Proceedings (OSTI)

A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

Jian Li

2012-11-07T23:59:59.000Z

46

NRP/Optineurin Cooperates with TAX1BP1 to Potentiate the Activation of NF-kB by Human T-Lymphotropic Virus  

E-Print Network (OSTI)

NRP/Optineurin Cooperates with TAX1BP1 to Potentiate the Activation of NF-kB by Human T Nuclear factor (NF)-kB is a major survival pathway engaged by the Human T-Lymphotropic Virus type 1 (HTLV-1) Tax protein. Tax1 activation of NF-kB occurs predominantly in the cytoplasm, where Tax1 binds NF-kB

Paris-Sud XI, Université de

47

Poxvirus Targeting of E3 Ligase b-TrCP by Molecular Mimicry: A Mechanism to Inhibit NF-kB Activation and  

E-Print Network (OSTI)

Poxvirus Targeting of E3 Ligase b-TrCP by Molecular Mimicry: A Mechanism to Inhibit NF-kB, Trinity College Dublin, Dublin, Ireland Abstract The transcription factor NF-kB is essential for immune degradation of IkBa. Here we describe an inhibitor of NF-kB from vaccinia virus that has a closely related

Utrecht, Universiteit

48

NF-kB activation by ultraviolet light not dependent on a nuclear signal  

Science Conference Proceedings (OSTI)

Exposure of mammalian cells to radiation triggers the ultraviolet (UV) response, which includes activation of activator protein-1 (AP-1) and nuclear factor kappa B (NF-kB). This was postulated to occur by induction of a nuclear signaling cascade by damaged DNA. Recently, induction of AP-1 by UV was shown to be mediated by a pathway involving Src tyrosine kinases and the Ha-Ras small guanosine triphosphate-binding protein, proteins located at the plasma membrane. It is demonstrated here that the same pathway mediates induction of NF-kB by UV. Because inactive NF-kB is stored in the cytosol, analysis of its activation directly tests the involvement of a nuclear-initiated signaling cascade. Enucleated cells are fully responsive to UV both in NF-kB induction and in activation of another key signaling event. Therefore, the UV response does not require a signal generated in the nucleus and is likely to be initiated at or near the plasma membrane.

Devary, Y.; Rosette, C.; DiDonato, J.A.; Karin, M. (Univ. of California, San Diego, CA (United States))

1993-09-10T23:59:59.000Z

49

Original article Induction of apoptosis and NF-B by quercetin  

E-Print Network (OSTI)

activity of NF-B, which may implicate an increasing resistance to their cytotoxicity. quercetin / TNF) Abstract -- Polyphenol quercetin induced apoptosis in proliferating murine L1210 lymphocytic cells. DNA promoting activity of quercetin was enhanced by physiological concentrations of TNF-. At the same time

Recanati, Catherine

50

IS NF-B A GOOD TARGET FOR CANCER THERAPY? HOPES AND PITFALLS  

E-Print Network (OSTI)

clear that aberrant regulation of NF-B and the signaling pathways that control its activity are involved and acquire drug resistance4, 5 . The current armamentarium of medical oncology includes many active, such as innate and adaptive immune responses, cell proliferation, cell death, and inflammation. It has become

Paris-Sud XI, Université de

51

Human papillomavirus type 16 E6 and E 7 proteins alter NF-kB in cultured cervical epithelial cells and inhibition of NF-kB promotes cell growth and immortalization  

Science Conference Proceedings (OSTI)

The NF-kB family of transcription factors regulates important biological functions including cell growth, survival and the immune response. We found that Human Papillomavirus type 16 (HPV-16) E7 and E6/E7 proteins inhibited basal and TNF-alpha-inducible NF-kB activity in human epithelial cells cultured from the cervical transformation zone, the anatomic region where most cervical cancers develop. In contrast, HPV-16 E6 regulated NF-kB in a cell type- and cell growth-dependent manner. NF-kB influenced immortalization of cervical cells by HPV16. Inhibition of NF-kB by an IkB alpha repressor mutant increased colony formation and immortalization by HPV-16. In contrast, activation of NF-kB by constitutive expression of p65 inhibited proliferation and immortalization. Our results suggest that inhibition of NF-kB by HPV-16 E6/E7 contributes to immortalization of cells from the cervical transformation zone.

Vandermark, Erik R.; Deluca, Krysta A.; Gardner, Courtney R.; Marker, Daniel F.; Schreiner, Cynthia N.; Strickland, David A.; Wilton, Katelynn M. [Department of Biology, Clarkson University, Potsdam, NY 13699-5805 (United States)] [Department of Biology, Clarkson University, Potsdam, NY 13699-5805 (United States); Mondal, Sumona [Department of Mathematics, Clarkson University, Potsdam, NY 13699-5805 (United States)] [Department of Mathematics, Clarkson University, Potsdam, NY 13699-5805 (United States); Woodworth, Craig D., E-mail: woodworth@clarkson.edu [Department of Biology, Clarkson University, Potsdam, NY 13699-5805 (United States)

2012-03-30T23:59:59.000Z

52

Purinergic Signaling is Required for Fluid Shear Stress-Induced NF-kB Translocation in Osteoblasts  

SciTech Connect

Fluid shear stress regulates gene expression in osteoblasts, in part by activation of the transcription factor NF-kB. We examined whether this process was under control of purinoceptor activation. MC3T3-E1 osteoblasts under static conditions expressed the NF-kB inhibitory protein IkB alpha and exhibited cytosolic localization of NF-kB. Under fluid shear stress, I?B? levels decreased, and concomitant nuclear localization of NF-kB was observed. Cells exposed to fluid shear stress in ATP-depleted medium exhibited no significant reduction in I?B?, and NF-kB remained within the cytosol. Similar results were found using oxidized ATP or Brilliant Blue G, P2X7 receptor antagonists, indicating that the P2X7 receptor is responsible for fluid shear-stress-induced I?B? degradation and nuclear accumulation of NF-kB. Pharmacologic blockage of the P2Y6 receptor also prevented shear-induced IkB alpha degradation. These phenomena involved neither ERK1/2 signaling nor autocrine activation by P2X7-generated lysophosphatidic acid. Our results suggest that fluid shear stress regulates NF-kB activity through the P2Y6 and P2X7 receptor.

Genetos, Damian C.; Karin, Norman J.; Geist, Derik J.; Donahue, Henry J.; Duncan, Randall L.

2011-04-01T23:59:59.000Z

53

Coal dust contiguity-induced changes in the concentration of TNF- and NF- B p65 on the ocular surface  

Science Conference Proceedings (OSTI)

To observe the influence of coal dust on ocular surface of coal miners and rabbits with coal dust contiguity on expression TNF- and NF- Bp65 and dry eye occurrence. Expression TNF- and NF- Bp65 in ocular surface were determined. Results showed tear production, BUT and lysozyme decreased for coal miners and rabbits with coal dust contiguity. Coal dust exposure was linked to development of xerophthalmia, and induced a higher expression of NF- B p65 and TNF- perhaps as a mechanism to resist coal dust ocular surface injury.

Sun, Z.Y.; Hong, J.; Liu, Z.Y.; Jin, X.D.; Gu, C.H. [China Medical University, Shenyang (China)

2009-07-01T23:59:59.000Z

54

Agreement Execution Process Study: CRADAs and NF-WFO Agreements and the Speed of Business  

SciTech Connect

This report summarizes the findings of a study on the execution of Cooperative Research and Development Agreements (CRADAs) and Non-Federal Work for Others (NF-WFO) agreements across the U.S. Department of Energy (DOE) laboratory complex. The study provides quantitiative estimates of times required to negotiate and execute these agreements across the DOE complex. It identifies factors impacting on cycle times and describes best practicies used at various laboratories and site offices that reduce cycle times.

Harrer, Bruce J.; Cejka, Cheryl L.; Macklin, Richard; Miksovic, Ann

2011-02-01T23:59:59.000Z

55

TRIM30a negatively regulates TLR-mediated NF-jB activation by targeting TAB2 and TAB3 for degradation  

E-Print Network (OSTI)

of the transcription factor NF-kB and stress-activated protein kinases5 and then induces the expression of genes encoding immune and proinflammatory molecules6. Activation of NF-kB by a TLR signal depends on the activity of the inhibitor of NF-kB (IkB) kinase (IKK) complex. In turn, activation of both IKK and TAK1 (A002249

Tian, Weidong

56

IKKa and IKKb Each Function to Regulate NF-kB Activation in the TNF-Induced/Canonical Pathway  

E-Print Network (OSTI)

Background: Activation of the transcription factor NF-kB by cytokines is rapid, mediated through the activation of the IKK complex with subsequent phosphorylation and degradation of the inhibitory IkB proteins. The IKK complex is comprised of two catalytic subunits, IKKa and IKKb, and a regulatory protein known as NEMO. Using cells from mice that are genetically deficient in IKKb or IKKa, or using a kinase inactive mutant of IKKb, it has been proposed that IKKb is critical for TNF-induced IkB phosphorylation/degradation through the canonical pathway while IKKa has been shown to be involved in the noncanonical pathway for NF-kB activation. These conclusions have led to a focus on development of IKKb inhibitors for potential use in inflammatory disorders and cancer. Methodology: Analysis of NF-kB activation in response to TNF in MEFs reveals that IKKb is essential for efficient phosphorylation and subsequent degradation of IkBa, yet IKKa contributes to the NF-kB activation response in these cells as measured via DNA binding assays. In HeLa cells, both IKKa and IKKb contribute to IkBa phosphorylation and NF-kB activation. A kinase inactive mutant of IKKb, which has been used as evidence for the critical importance of IKKb in TNFinduced signaling, blocks activation of NF-kB induced by IKKa, even in cells that are deficient in IKKb. Conclusions: These results demonstrate the importance of IKKa in canonical NF-kB activation, downstream of cytokine

Mazhar Adli; Evan Merkhofer; Patricia Cogswell; Albert S. Baldwin

2009-01-01T23:59:59.000Z

57

XIAP Induces NF-kB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization  

Science Conference Proceedings (OSTI)

In addition to caspase inhibition, X-linked inhibitor of apoptosis (XIAP) induces NF-{kappa}B and MAP kinase activation during TGF-b and BMP receptor signaling and upon overexpression. Here we show that the BIR1 domain of XIAP, which has no previously ascribed function, directly interacts with TAB1 to induce NF-{kappa}B activation. TAB1 is an upstream adaptor for the activation of the kinase TAK1, which in turn couples to the NF-{kappa}B pathway. We report the crystal structures of BIR1, TAB1, and the BIR1/TAB1 complex. The BIR1/TAB1 structure reveals a striking butterfly-shaped dimer and the detailed interaction between BIR1 and TAB1. Structure-based mutagenesis and knockdown of TAB1 show unambiguously that the BIR1/TAB1 interaction is crucial for XIAP-induced TAK1 and NF-{kappa}B activation. We show that although not interacting with BIR1, Smac, the antagonist for caspase inhibition by XIAP, also inhibits the XIAP/TAB1 interaction. Disruption of BIR1 dimerization abolishes XIAP-mediated NF-{kappa}B activation, implicating a proximity-induced mechanism for TAK1 activation.

Lu,M.; Lin, S.; Huang, Y.; Kang, Y.; Rich, R.; Lo, Y.; Myszka, D.; Han, J.; Wu, H.

2007-01-01T23:59:59.000Z

58

The Enteropathogenic E. coli (EPEC) Tir Effector Inhibits NF-kB Activity by Targeting TNFa Receptor-Associated Factors  

E-Print Network (OSTI)

Enteropathogenic Escherichia coli (EPEC) disease depends on the transfer of effector proteins into epithelia lining the human small intestine. EPEC E2348/69 has at least 20 effector genes of which six are located with the effector-delivery system genes on the Locus of Enterocyte Effacement (LEE) Pathogenicity Island. Our previous work implied that non-LEE-encoded (Nle) effectors possess functions that inhibit epithelial anti-microbial and inflammation-inducing responses by blocking NF-kB transcription factor activity. Indeed, screens by us and others have identified novel inhibitory mechanisms for NleC and NleH, with key co-operative functions for NleB1 and NleE1. Here, we demonstrate that the LEE-encoded Translocatedintimin receptor (Tir) effector has a potent and specific ability to inhibit NF-kB activation. Indeed, biochemical, imaging and immunoprecipitation studies reveal a novel inhibitory mechanism whereby Tir interaction with cytoplasm-located TNFa receptor-associated factor (TRAF) adaptor proteins induces their proteasomal-independent degradation. Infection studies support this Tir-TRAF relationship but reveal that Tir, like NleC and NleH, has a non-essential contribution in EPECs NF-kB inhibitory capacity linked to Tirs activity being suppressed by undefined EPEC factors. Infections in a disease-relevant intestinal model confirm key NF-kB inhibitory roles for the NleB1/NleE1 effectors, with other studies providing insights on host targets. The work not only reveals a second Intimin-independent property for Tir and a novel EPEC effector-mediated NF-kB inhibitory mechanism but also lends itself to speculations on the evolution of EPECs capacity to inhibit NF-kB

Marie-hlne Ruchaud-sparagano; Sabrina Mhlen; Paul Dean; Brendan Kenny

2011-01-01T23:59:59.000Z

59

The Surface Activation Layer of GaAs Negative Electron Affinity Photocathode Activated by Cs, Li and NF3  

Science Conference Proceedings (OSTI)

The lifetime of GaAs photocathodes can be greatly improved by introducing Li in the Cs+NF{sub 3} activation process. The surface activation layer of such photocathodes is studied by synchrotron radiation photoemission and is compared with GaAs photocathodes activated without Li. The charge distributions of N, F and Cs experience significant changes when Li is added in the activation. In addition, the presence of Li causes NF{sub x} molecules to take an orientation with F atoms on top. All these changes induced by Li hold the key for the lifetime improvement of GaAs photocathodes.

Sun, Yun; /SLAC, SSRL; Kirby, R.E.; /Saxet Surface Sci.; Maruyama, T.; /SLAC; Mulhollan, G.A.; Bierman, J.C.; /Saxet Surface Sci.; Pianetta, P.; /SLAC, SSRL

2009-12-11T23:59:59.000Z

60

Introducing Spatial Information into Predictive NF-kB Modelling An Agent-Based Approach  

E-Print Network (OSTI)

Nature is governed by local interactions among lower-level sub-units, whether at the cell, organ, organism, or colony level. Adaptive system behaviour emerges via these interactions, which integrate the activity of the sub-units. To understand the system level it is necessary to understand the underlying local interactions. Successful models of local interactions at different levels of biological organisation, including epithelial tissue and ant colonies, have demonstrated the benefits of such agent-based modelling [14]. Here we present an agent-based approach to modelling a crucial biological system the intracellular NF-kB signalling pathway. The pathway is vital to immune response regulation, and is fundamental to basic survival in a range of species [57]. Alterations in pathway regulation underlie a variety of diseases, including atherosclerosis and arthritis. Our modelling of individual molecules, receptors and genes provides a more comprehensive outline of regulatory network mechanisms than previously possible with equation-based approaches [8]. The method also permits consideration of structural parameters in pathway regulation; here we predict that inhibition of NF-kB is directly affected by actin filaments of the cytoskeleton sequestering excess inhibitors, therefore regulating steady-state and feedback

Mark Pogson; Mike Holcombe; Rod Smallwood; Eva Qwarnstrom

2008-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

The TCL1A Oncoprotein Interacts Directly with the NF-kB Inhibitor IkB  

E-Print Network (OSTI)

The T cell leukaemia/lymphoma 1A (TCL1A) oncoprotein plays key roles in several B and T cell malignancies. Lacking enzymatic activity, TCL1As transforming action was linked to its capacity to co-activate the protein kinase AKT via binding to its pleckstrin homology (PH) domain. However, perturbation of AKT signalling alone was recently shown insufficient to explain TCL1A oncogenesis, suggesting that TCL1A has additional cellular partners. Searching for such additional targets, we found that TCL1A binds specifically and directly to the ankyrin domain of IkB, the inhibitor of the NF-kB transcription factors. Through binding assays and a structural analysis by small angle X-ray scattering, we show that TCL1A and IkB interact in yeast-two-hybrid systems, when transiently overexpressed in 293 cells, and as recombinant proteins in vitro. We further establish that the association between TCL1A and IkB is compatible with AKT binding to TCL1A, but incompatible with IkB binding to NF-kB. By interfering with the inhibition of NF-kB byIkB, TCL1A may increase the concentration of free NF-kB molecules sufficiently to trigger expression of anti-apoptotic genes. Thus our data suggest an additional route by

Virginie Ropars; Gilles Despouy; Marc-henri Stern; Serge Benichou; Stefan T. Arold

2009-01-01T23:59:59.000Z

62

Nat Rev Drug Discov. Author manuscript Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls  

E-Print Network (OSTI)

and the signaling pathways that control its activity are involved in cancer development and progression, as well resistance , .4 5 The current armamentarium of medical oncology includes many active anticancer agents, cell proliferation, cell death, and inflammation. It has become clear that aberrant regulation of NF- B

Paris-Sud XI, Université de

63

Towards thermodynamics with $N_f=2+1+1$ twisted mass quarks  

E-Print Network (OSTI)

We present preliminary results achieved within a recently started project dealing with QCD thermodynamics in the presence of a fully dynamical second quark family. We are employing the Wilson twisted mass discretization. To reduce the amount of zero temperature simulations and the cost of analysis we have chosen the fixed-scale approach. We show a variety of basic thermodynamic observables for temperatures ranging from 158 to 633 MeV. Simulations were performed for three lattice spacings below 0.1 fm each and at a single value of the pion mass which allows a comparison with previously obtained $N_f=2$ results. We determine the chiral crossover temperature from the bare chiral susceptibility and show results for the gauge part of the trace anomaly.

Florian Burger; Grit Hotzel; Michael Mller-Preussker; Ernst-Michael Ilgenfritz; Maria Paola Lombardo

2013-11-07T23:59:59.000Z

64

Determining the conformal window: SU(2) gauge theory with N_f = 4, 6 and 10 fermion flavours  

E-Print Network (OSTI)

We study the evolution of the coupling in SU(2) gauge field theory with $N_f=4$, 6 and 10 fundamental fermion flavours on the lattice. These values are chosen close to the expected edges of the conformal window, where the theory possesses an infrared fixed point. We use improved Wilson-clover action, and measure the coupling in the Schr\\"odinger functional scheme. At four flavours we observe that the couping grows towards the infrared, implying QCD-like behaviour, whereas at ten flavours the results are compatible with a Banks-Zaks type infrared fixed point. The six flavour case remains inconclusive: the evolution of the coupling is seen to become slower at the infrared, but the accuracy of the results falls short from fully resolving the fate of the coupling. We also measure the mass anomalous dimension for the $N_f=6$ case.

Tuomas Karavirta; Jarno Rantaharju; Kari Rummukainen; Kimmo Tuominen

2011-11-17T23:59:59.000Z

65

KT McDonald IDS-NF Plenary Meeting (RAL) Apr 6, 20132 1 Engineering Issues for the  

E-Print Network (OSTI)

Diagnostics Controls and Interlocks Health and Safety Mechanical Decommissioning Remote Handling and Hot Cells 10,730,099 1.06.07 - Remote Handling Systems 14,348,362 1.06.08 - Controls 3,076,899 1.06.09 - Beam. #12;KT McDonald IDS-NF Plenary Meeting (RAL) Apr 6, 20132 19 We must have an activated-air handling

McDonald, Kirk

66

GEF-H1 Mediated Control of NOD1 Dependent NF-kB Activation by Shigella Effectors  

E-Print Network (OSTI)

Shigella flexneri has evolved the ability to modify host cell function with intracellular active effectors to overcome the intestinal barrier. The detection of these microbial effectors and the initiation of innate immune responses are critical for rapid mucosal defense activation. The guanine nucleotide exchange factor H1 (GEF-H1) mediates RhoA activation required for cell invasion by the enteroinvasive pathogen Shigella flexneri. Surprisingly, GEF-H1 is requisite for NF-kB activation in response to Shigella infection. GEF-H1 interacts with NOD1 and is required for RIP2 dependent NF-kB activation by H-Ala-DcGlu-DAP (cTriDAP). GEF-H1 is essential for NF-kB activation by the Shigella effectors IpgB2 and OspB, which were found to signal in a NOD1 and RhoA Kinase (ROCK) dependent manner. Our results demonstrate that GEF-H1 is a critical component of cellular defenses forming an intracellular sensing system with NOD1 for the detection of microbial effectors during cell

Atsuko Fukazawa; Carmen Alonso; Kiyotaka Kurachi; Sonal Gupta; Cammie F. Lesser; Beth Ann; Hans-christian Reinecker

2008-01-01T23:59:59.000Z

67

Dual Delayed Feedback Provides Sensitivity and Robustness to the NF-kB Signaling Module  

E-Print Network (OSTI)

Many cellular stress-responsive signaling systems exhibit highly dynamic behavior with oscillatory features mediated by delayed negative feedback loops. What remains unclear is whether oscillatory behavior is the basis for a signaling code based on frequency modulation (FM) or whether the negative feedback control modules have evolved to fulfill other functional requirements. Here, we use experimentally calibrated computational models to interrogate the negative feedback loops that regulate the dynamic activity of the transcription factor NF-kB. Linear stability analysis of the model shows that oscillatory frequency is a hard-wired feature of the primary negative feedback loop and not a function of the stimulus, thus arguing against an FM signaling code. Instead, our modeling studies suggest that the two feedback loops may be tuned to provide for rapid activation and inactivation capabilities for transient input signals of a wide range of durations; by minimizing late phase oscillations response durations may be fine-tuned in a graded rather than quantized manner. Further, in the presence of molecular noise the dual delayed negative feedback system minimizes stochastic

Diane M. Longo; Jangir Selimkhanov; Jeffrey D. Kearns; Jeff Hasty; Er Hoffmann; Lev S. Tsimring

2013-01-01T23:59:59.000Z

68

NF-kB Hyper-Activation by HTLV-1 Tax Induces Cellular Senescence, but Can Be Alleviated by the Viral Anti- Sense Protein HBZ  

E-Print Network (OSTI)

Activation of I-kB kinases (IKKs) and NF-kB by the human T lymphotropic virus type 1 (HTLV-1) trans-activator/oncoprotein, Tax, is thought to promote cell proliferation and transformation. Paradoxically, expression of Tax in most cells leads to drastic up-regulation of cyclin-dependent kinase inhibitors, p21 CIP1/WAF1 and p27 KIP1, which cause p53-/pRb-independent cellular senescence. Here we demonstrate that p21 CIP1/WAF1-/p27 KIP1-mediated senescence constitutes a checkpoint against IKK/NF-kB hyper-activation. Senescence induced by Tax in HeLa cells is attenuated by mutations in Tax that reduce IKK/NFkB activation and prevented by blocking NF-kB using a degradation-resistant mutant of I-kBa despite constitutive IKK activation. Small hairpin RNA-mediated knockdown indicates that RelA induces this senescence program by acting upstream of the anaphase promoting complex and RelB to stabilize p27 KIP1 protein and p21 CIP1/WAF1 mRNA respectively. Finally, we show that down-regulation of NF-kB by the HTLV-1 anti-sense protein, HBZ, delay or prevent the onset of Taxinduced senescence. We propose that the balance between Tax and HBZ expression determines the outcome of HTLV-1 infection. Robust HTLV-1 replication and elevated Tax expression drive IKK/NF-kB hyper-activation and trigger senescence. HBZ, however, modulates Tax-mediated viral replication and NF-kB activation, thus allowing HTLV-1-infected cells to proliferate, persist, and evolve. Finally, inactivation of the senescence checkpoint can facilitate persistent NF-kB activation

Huijun Zhi; Liangpeng Yang; Yu-liang Kuo; Yik-khuan Ho; Hsiu-ming Shih; Chou-zen Giam

2011-01-01T23:59:59.000Z

69

Non-Canonical NF-kB Activation and Abnormal B Cell Accumulation in Mice Expressing Ubiquitin Protein Ligase-Inactive c-IAP2  

E-Print Network (OSTI)

Chromosomal translocations between loci encoding MALT1 and c-IAP2 are common in MALT lymphomas. The resulting fusion proteins lack the c-IAP2 RING domain, the region responsible for its ubiquitin protein ligase (E3) activity. Ectopic expression of the fusion protein activates the canonical NF-kB signaling cascade, but how it does so is controversial and how it promotes MALT lymphoma is unknown. Considering recent reports implicating c-IAP1 and c-IAP2 E3 activity in repression of non-canonical NF-kB signaling, we asked if the c-IAP2/MALT fusion protein can initiate non-canonical NF-kB activation. Here we show that in addition to canonical activation, the fusion protein stabilizes NIK and activates noncanonical NF-kB. Canonical but not non-canonical activation depended on MALT1 paracaspase activity, and expression of E3-inactive c-IAP2 activated non-canonical NF-kB. Mice in which endogenous c-IAP2 was replaced with an E3-inactive mutant accumulated abnormal B cells with elevated non-canonical NF-kB and had increased numbers of B cells with a marginal zone phenotype, gut-associated lymphoid hyperplasia, and other features of MALT lymphoma. Thus, the c-IAP2/ MALT1 fusion protein activates NF-kB by two distinct mechanisms, and loss of c-IAP2 E3 activity in vivo is sufficient to induce abnormalities common to MALT lymphoma.

Dietrich B. Conze; Yongge Zhao; Jonathan D. Ashwell

2010-01-01T23:59:59.000Z

70

Dual mechanisms of NF-kappaB inhibition in carnosol-treated endothelial cells  

Science Conference Proceedings (OSTI)

The increased adhesion of monocytes to injured endothelial layers is a critical early event in atherogenesis. Under inflammatory conditions, there is increased expression of specific cell adhesion molecules on activated vascular endothelial cells, which increases monocyte adhesion. In our current study, we demonstrate a putative mechanism for the anti-inflammatory effects of carnosol, a diterpene derived from the herb rosemary. Our results show that both carnosol and rosemary essential oils inhibit the adhesion of TNFalpha-induced monocytes to endothelial cells and suppress the expression of ICAM-1 at the transcriptional level. Moreover, carnosol was found to exert its inhibitory effects by blocking the degradation of the inhibitory protein IkappaBalpha in short term pretreatments but not in 12 h pretreatments. Our data show that carnosol reduces IKK-beta phosphorylation in pretreatments of less than 3 h. In TNFalpha-treated ECs, NF-kappaB nuclear translocation and transcriptional activity was abolished by up to 12 h of carnosol pretreatment and this was blocked by Nrf-2 siRNA. The long-term inhibitory effects of carnosol thus appear to be mediated through its induction of Nrf-2-related genes. The inhibition of ICAM-1 expression and p65 translocation is reversed by HO-1 siRNA. Carnosol also upregulates the Nrf-2-related glutathione synthase gene and thereby increases the GSH levels after 9 h of exposure. Treating ECs with a GSH synthesis inhibitor, BSO, blocks the inhibitory effects of carnosol. In addition, carnosol increases p65 glutathionylation. Hence, our present findings indicate that carnosol suppresses TNFalpha-induced singling pathways through the inhibition of IKK-beta activity or the upregulation of HO-1 expression. The resulting GSH levels are dependent, however, on the length of the carnosol pretreatment period.

Lian, K.-C.; Chuang, J.-J.; Hsieh, C.-W. [Department of Microbiology and Immunology, National Chiayi University, Chiayi, Taiwan (China); Wung, B.-S., E-mail: bswung@mail.ncyu.edu.t [Department of Microbiology and Immunology, National Chiayi University, Chiayi, Taiwan (China); Huang, G.-D.; Jian, T.-Y. [Department of Microbiology and Immunology, National Chiayi University, Chiayi, Taiwan (China); Sun, Y.-W. [Department of Biotechnology, Seed Improvement and Propagation Station, Taichung, Taiwan (China)

2010-05-15T23:59:59.000Z

71

Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling  

SciTech Connect

SET domain containing 6 (SETD6) monomethylates the RelA subunit of nuclear factor kappa B (NF-{kappa}B). The ankyrin repeats of G9a-like protein (GLP) recognizes RelA monomethylated at Lys310. Adjacent to Lys310 is Ser311, a known phosphorylation site of RelA. Ser311 phosphorylation inhibits Lys310 methylation by SETD6 as well as binding of Lys310me1 by GLP. The structure of SETD6 in complex with RelA peptide containing the methylation site, in the presence of S-adenosyl-l-methionine, reveals a V-like protein structure and suggests a model for NF-{kappa}B binding to SETD6. In addition, structural modeling of the GLP ankyrin repeats bound to Lys310me1 peptide provides insight into the molecular basis for inhibition of Lys310me1 binding by Ser311 phosphorylation. Together, these findings provide a structural explanation for a key cellular signaling pathway centered on RelA Lys310 methylation, which is generated by SETD6 and recognized by GLP, and incorporate a methylation-phosphorylation switch of adjacent lysine and serine residues. Finally, SETD6 is structurally similar to the Rubisco large subunit methyltransferase. Given the restriction of Rubisco to plant species, this particular appearance of the protein lysine methyltransferase has been evolutionarily well conserved.

Chang, Yanqi; Levy, Dan; Horton, John R.; Peng, Junmin; Zhang, Xing; Gozani, Or; Cheng, Xiaodong (Emory-MED); (Stanford)

2011-10-10T23:59:59.000Z

72

Regulation of cytochrome P450 3A4 gene expression through modulating pregnane X receptor transcriptional activity by NF-? aryl hydrocarbon receptor and xenobiotics  

E-Print Network (OSTI)

Cytochrome P450 3A4 (CYP3A4) is a key enzyme responsible for the metabolism of drugs and endogenous compounds in human liver and intestine. CYP3A4 gene expression is mainly regulated by Pregnane X receptor (PXR) which is a ligand-dependent nuclear receptor. It is a long-standing observation that inflammatory responses and infections decrease drug metabolism capacity in human and experimental animals. In this study, I reported that NF-?B activation by LPS and TNF-? plays a pivotal role in the suppression of CYP3A4 through interactions of NF-?B with PXR/RXR complex. Inhibition of NF-?B by NF-?B specific suppressor SRI?B? reversed the suppressive effects of LPS and TNF-?. Furthermore, I showed that NF-?B p65 disrupted the association of PXR/RXR? complex with DNA sequences as determined by EMSA and chromatin immunoprecipitation assays. NF-?B p65 directly interacted with DNA binding domain of RXR? and DNA binding domain, hinge domain and ligand-binding domain of PXR and may prevent its binding to the consensus DNA sequences, thus inhibiting the transactivation by PXR/RXR? complex. This mechanism of suppression by NF-?B activation may be extended to other nuclear receptor-regulated systems where RXR? is a dimerization partner. Many genes regulated by PXR and AhR are important for phase I, II and III drug metabolism. In this study I reported a crosstalk between PXR and AhR pathways. AhR physically and functionally interacted with PXR and enhanced the PXR transcriptional activity, and the interaction repressed the AhR transcriptional activity. AhR also physically interacted with RXR?. The synergistic induction of Gsta1 in the liver of mice by PCN and TCDD might assume a different mechanism. The results suggested the metabolism kinetics of mixture drugs was different from and more complicated than that of single compound. Using a HepG2 cell-based PXR-driven CYP3A4-Luciferase assay, I reported that E/F domain of PXR was responsible for ligand-dependant activation. A/B domain was necessary for co-activating the ligand-dependent activation and D domain was suppressive. High doses of Valerian Root extraction were PXR-dependent CYP3A4 inducers. Green tea polyphenols, aflatoxin B1, CuSO4 and MnCl2 enhanced the PXR transcription activity activated by rifampicin. The results suggested PXR-mediated drug metabolism kinetics altered on xenobiotic exposure.

Gu, Xinsheng

2007-08-01T23:59:59.000Z

73

Effect of phenobarbital on hepatic cell proliferation and apoptosis in mice deficient in the p50 subunit of NF-{kappa}B  

Science Conference Proceedings (OSTI)

Phenobarbital (PB) is a nongenotoxic tumor promoter in the liver. One mechanism by which PB may exert its tumor promoting activity is by inducing oxidative stress. We previously found that PB administration increased hepatic NF-{kappa}B DNA binding activity. In this study we examined the hypothesis that the effects of PB on cell proliferation and apoptosis are dependent on NF-{kappa}B. We used a mouse model that is deficient in the p50 subunit of NF-{kappa}B; previous studies had found that p50-/- mice were less sensitive to the induction of hepatic cell proliferation by PCBs or peroxisome proliferators. Mice (p50-/- and wild-type B6129) were fed a control diet or one containing 0.05% PB for 3, 10 or 34 days. At the end of the experiment, the mice were euthanized and livers removed and processed. PB increased cell proliferation at 3 and 10 days (but not at 34 days), but the deletion of the NF-{kappa}B p50 subunit did not inhibit these increases. p50-/- Mice had higher cell proliferation at the 3 day (only in mice fed PB) and 34-day timepoints. PB decreased hepatocyte apoptosis after 3 days, slightly decreased it after 10 days, and did not affect it after 34 days. The deletion of the NF-{kappa}B p50 subunit did not influence PB's effect on apoptosis. In p50-/- mice, apoptosis was increased after 3 or 10 days compared to wild-type mice, but no effect was seen after 34 days. The hepatic expression of the NF-{kappa}B-regulated gene TNF-{alpha} correlated more with the hepatic cell proliferation data than with hepatic apoptosis, and was not decreased by the deletion of the p50 subunit. These findings show that the p50 subunit of NF-{kappa}B is not required for the alteration of hepatocyte proliferation or apoptosis by PB up to 34 days after its administration.

Tharappel, Job C. [Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky (United States); Spear, Brett T. [Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky (United States); Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky (United States); Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (United States); Glauert, Howard P. [Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky (United States); Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (United States)], E-mail: hglauert@uky.edu

2008-02-01T23:59:59.000Z

74

Artemisolide is a typical inhibitor of I{kappa}B kinase {beta} targeting cysteine-179 residue and down-regulates NF-{kappa}B-dependent TNF-{alpha} expression in LPS-activated macrophages  

SciTech Connect

Nuclear factor (NF)-{kappa}B regulates a central common signaling for immunity and cell survival. Artemisolide (ATM) was previously isolated as a NF-{kappa}B inhibitor from a plant of Artemisia asiatica. However, molecular basis of ATM on NF-{kappa}B activation remains to be defined. Here, we demonstrate that ATM is a typical inhibitor of I{kappa}B kinase {beta} (IKK{beta}), resulting in inhibition of lipopolysaccharide (LPS)-induced NF-{kappa}B activation in RAW 264.7 macrophages. ATM inhibited the kinase activity of highly purified IKK{beta} and also LPS-induced IKK activity in the cells. Moreover, the effect of ATM on IKK{beta} activity was completely abolished by substitution of Cys-179 residue of IKK{beta} to Ala residue, indicating direct targeting site of ATM. ATM could inhibit I{kappa}B{alpha} phosphorylation in LPS-activated RAW 264.7 cells and subsequently prevent NF-{kappa}B activation. Further, we demonstrate that ATM down-regulates NF-{kappa}B-dependent TNF-{alpha} expression. Taken together, this study provides a pharmacological potential of ATM in NF-{kappa}B-dependent inflammatory disorders.

Kim, Byung Hak; Lee, Jun-Young; Seo, Jee Hee; Lee, Hwa Young [College of Pharmacy, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Ryu, Shi Yong [Korea Research Institute of Chemical Technology, Taejon 305-600 (Korea, Republic of); Ahn, Byung Woo [College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Lee, Chong-Kil; Hwang, Bang Yeon; Han, Sang-Bae [College of Pharmacy, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Kim, Youngsoo [College of Pharmacy, Chungbuk National University, Cheongju 361-763 (Korea, Republic of)], E-mail: youngsoo@chungbuk.ac.kr

2007-09-28T23:59:59.000Z

75

$K$ and $D$ oscillations in the Standard Model and its extensions from $N_f=2+1+1$ Twisted Mass LQCD  

E-Print Network (OSTI)

We present the first $N_f=2+1+1$ results for the matrix elements of the operators describing neutral $K$ and $D$ mixing in the Standard Model and its extensions. The combination of maximally twisted sea quarks and Osterwalder-Seiler valence quarks ensures $\\mathcal{O}(a)$-improvement and continuum like renormalization pattern. We have used the $N_f=2+1+1$ dynamical quark gauge configurations generated by ETMC. Simulations include three lattice spacings in the interval $[0.06:0.09]$ fm and pseudoscalar meson masses in the range $[230:500]$ MeV. Our results are extrapolated to the continuum limit and to the physical quark masses. The calculation of the renormalization constants has been performed non-perturbatively in the RI-MOM scheme.

Carrasco, Nuria; Frezzotti, Roberto; Gimnez, Vicent; Lubicz, Vittorio; Rossi, Giancarlo; Sanfilippo, Francesco; Tarantino, Cecilia

2013-01-01T23:59:59.000Z

76

The human NFKB3 gene encoding the p65 subunit of transcription factor NF-[sub K]B is located on chromosome 11q12  

SciTech Connect

A YAC clone that contains the human gene NFKB3, encoding the p65 subunit of transcription factor nuclear factor [sub K]B (NF-[sub K]B), was isolated. The YAC contains the entire NFKB3 gene, which is smaller than 15 kb and present in a single copy in the genome. Fluorescence in situ hybridization with metaphase chromosomes showed two different chromosomal locations (11q12 and Xp11.4) for sequences present in the YAC. The NFKB3 gene was assigned to chromosome 11q12 by PCR analysis of a panel of relevant hybrid cell lines. Thus, no linkage exists between NFKB3 and genes encoding other known members of the NF-[sub K]B family. 20 refs., 2 figs.

Deloukas, P.; Loon, A.P.G.M. van (F. Hoffmann-La Roche Ltd., Basel (Switzerland)); Dauwerse, J.G.; Ommen, G.J.B. van (Univ. of Leiden (Netherlands))

1994-02-01T23:59:59.000Z

77

Fucoidan prevents C{epsilon} germline transcription and NF{kappa}B p52 translocation for IgE production in B cells  

SciTech Connect

Fucoidan, a dietary fiber contained in seaweed, reduces the increase of antigen-specific IgE in mice exposed to ovalbumin. In this study, we investigated the effect of fucoidan on IgE production and intracellular events in B cells in vitro. Fucoidan inhibited the production of IgE and C{epsilon} germline transcription in murine B cells induced by IL-4 (100 ng/ml) and anti-CD40 antibodies (10 {mu}g/ml), whereas it stimulated cell proliferation. A significant effect of fucoidan on IgE production was observed when B cells were stimulated with a higher dose (5 {mu}g/ml) of anti-CD40 antibodies, but not when stimulated with lower doses (1.25, 2.5 {mu}g/ml), regardless of the IL-4 concentrations. Moreover, nuclear translocation of NF{kappa}B p52, but neither that of NF{kappa}B p65, nor the phosphorylation of JAK1 and STAT6 was reduced by fucoidan. These results suggest that fucoidan inhibited IgE production by preventing the NF{kappa}B p52-mediated pathways activated by CD40.

Oomizu, Souichi [Hiroshima Prefectural Institute of Industrial Science and Technology, Higashi-Hiroshima (Japan); Yanase, Yuhki [Hiroshima Prefectural Institute of Industrial Science and Technology, Higashi-Hiroshima (Japan); Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan); Suzuki, Hidenori [Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan); Kameyoshi, Yoshikazu [Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan); Hide, Michihiro [Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan)]. E-mail: mhide@hiroshima-u.ac.jp

2006-11-24T23:59:59.000Z

78

Research Article Curcumin Decreased Oxidative Stress, Inhibited NF-?B Activation, and Improved Liver Pathology in Ethanol-Induced Liver Injury in Rats  

E-Print Network (OSTI)

To study the mechanism of curcumin-attenuated inflammation and liver pathology in early stage of alcoholic liver disease, female Sprague-Dawley rats were divided into four groups and treated with ethanol or curcumin via an intragastric tube for 4 weeks. A control group treated with distilled water, and an ethanol group was treated with ethanol (7.5 g/kg bw). Treatment groups were fed with ethanol supplemented with curcumin (400 or 1 200 mg/kg bw). The liver histopathology in ethanol group revealed mild-tomoderate steatosis and mild necroinflammation. Hepatic MDA, hepatocyte apoptosis, and NF-?B activation increased significantly in ethanol-treated group when compared with control. Curcumin treatments resulted in improving of liver pathology, decreasing the elevation of hepatic MDA, and inhibition of NF-?B activation. The 400 mg/kg bw of curcumin treatment revealed only a trend of decreased hepatocyte apoptosis. However, the results of SOD activity, PPAR? protein expression showed no difference among the groups. In conclusion, curcumin improved liver histopathology in early stage of ethanol-induced liver injury by reduction of oxidative stress and inhibition of NF-?B activation. Copyright 2009 Suchittra Samuhasaneeto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1.

Suchittra Samuhasaneeto; Duangporn Thong-ngam; Onanong Kulaputana; Doungsamon Suyasunanont; Naruemon Klaikeaw

2009-01-01T23:59:59.000Z

79

DETEW!INATION OF THE NEUTRON MAGNETIC FlONENT G.L. Greene and N.F. Ramsey  

NLE Websites -- All DOE Office Websites (Extended Search)

DETEW!INATION OF THE NEUTRON MAGNETIC FlONENT DETEW!INATION OF THE NEUTRON MAGNETIC FlONENT * G.L. Greene and N.F. Ramsey Harvard U n i v e r s i t y , Cambridge, N a s s a c h u s e t t s 02138 h W. Plampe i - I n s t i t u t Laue-Langevin, 38042 Grenoble, France' 9/ \ P J . M . P e n d l e b u r y and K. Smith " ' , \30ddb * A , 4 U n i v e r s i t y o f S u s s e x , Falmer, B r i g h t o n , B N I 9 Q H , U n i t e d Kingdom W . B . Dress and P.D. Miller -3 Oak Ridge N a t i o n a l L a b o r a t o r y , Oak Ridge, Tennessee 37838 P a u l P e r r i n C e n t r e d ' E t u d e s N u c l e a i r e s , 38042 C r e n o b l e , F r a n c e The n e u t r o n m a g n e t i c moment h a s been measured w i t h an improvement of a f a c t o r of 100 o v e r t h e p r e v i o u s b e s t measurement. s p e c t r o m e t e r o f t h e s e p a r a t e d o s c i l l a t o r y f i e l d t y p e c a p a b l e o f d e t e r m i n i n g a r e s o n a n c e s i g n a l f o r b o t h n e u t r o n s and p r o t o n s ( i n f l o w i n g H20), we f i n d u n / p p = 0.68497935(17)

80

Astroglial Inhibition of NF-kB Does Not Ameliorate Disease Onset and Progression in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)  

E-Print Network (OSTI)

Motor neuron death in amyotrophic lateral sclerosis (ALS) is considered a non-cell autonomous process, with astrocytes playing a critical role in disease progression. Glial cells are activated early in transgenic mice expressing mutant SOD1, suggesting that neuroinflammation has a relevant role in the cascade of events that trigger the death of motor neurons. An inflammatory cascade including COX2 expression, secretion of cytokines and release of NO from astrocytes may descend from activation of a NF-kB-mediated pathway observed in astrocytes from ALS patients and in experimental models. We have attempted rescue of transgenic mutant SOD1 mice through the inhibition of the NF-kB pathway selectively in astrocytes. Here we show that despite efficient inhibition of this major pathway, double transgenic mice expressing the mutant SOD1 G93A ubiquitously and the dominant negative form of IkBa (IkBaAA) in astrocytes under control of the GFAP promoter show no benefit in terms of onset and progression of disease. Our data indicate that motor neuron death in ALS cannot be prevented by inhibition of a single inflammatory pathway because alternative pathways are activated in the

Claudia Crosio; Cristiana Valle; Arianna Casciati; Ciro Iaccarino; Maria Teresa Carr

2011-01-01T23:59:59.000Z

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81

nf]r Z  

E-Print Network (OSTI)

Dear Dr. Eggenberger: This letter provides a status ofthe Office of Environmental Management (EM) actions to complete Commitment 4.4 ofthe Department ofEnergy's (DOE) Implementation Plan for Recommendation 2002-3, Requirements for the Design, Implementation, and Maintenance ofAdministrative Controls. The commitment calls for the submission ofa report on training completed and copies ofchanges to relevant training plans regarding DOE-STD-II86-2004, Specific Administrative Controls. On November 4, 2004, the Secretary revised the due date to May 31, 2005, to allow additional time after the issuance ofthe standard in August 2004. We expect all EM actions under this commitment to be met within 90 days. EM sites and activities have completed the required initial training, except for one site. The contractor at the Richland Operations Office has initiated training and will complete the training in early June 2005. A summary ofthe training conducted at EM sites is enclosed. In addition, a compact disc containing the detailed training modules has been provided to your staff. EM sites are using a variety ofmeans to institutionalize DOE STD-1186-2004 into the various training programs as shown in the enclosure. These activities are in progress and are to be completed within 90 days. Ifyou have any further questions, please call me at (202) 586-7709 or

Jij-j L. L' i U H; I L. -' " ' i; The Honorable; A. J. Eggenberger

2005-01-01T23:59:59.000Z

82

4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-{kappa}B and ERK/MAPK  

Science Conference Proceedings (OSTI)

Catechol estrogens, the hydroxylated metabolites of 17{beta}-estradiol (E{sub 2}), have been considered to be implicated in estrogen-induced carcinogenesis. 4-Hydroxyestradiol (4-OHE{sub 2}), an oxidized metabolite of E{sub 2} formed preferentially by cytochrome P450 1B1, reacts with DNA to form depurinating adducts thereby exerting genotoxicity and carcinogenicity. 4-OHE{sub 2} undergoes 2-electron oxidation to quinone via semiquinone, and during this process, reactive oxygen species (ROS) can be generated to cause DNA damage and cell death. In the present study, 4-OHE{sub 2} was found to elicit cytotoxicity in cultured human mammary epithelial (MCF-10A) cells, which was blocked by the antioxidant trolox. MCF-10A cells treated with 4-OHE{sub 2} exhibited increased intracellular ROS accumulation and 8-oxo-7,8-dihydroxy-2'-deoxyguanosine formation, and underwent apoptosis as determined by poly(ADP-ribose)polymerase cleavage and disruption of mitochondrial transmembrane potential. The redox-sensitive transcription factor nuclear factor {kappa}B (NF-{kappa}B) was transiently activated by 4-OHE{sub 2} treatment. Cotreatment of MCF-10A cells with the NF-{kappa}B inhibitor, L-1-tosylamido-2-phenylethyl chloromethyl ketone, exacerbated 4-OHE{sub 2}-induced cell death. 4-OHE{sub 2} also caused transient activation of extracellular signal-regulated protein kinases (ERK) involved in transmitting cell survival or death signals. A pharmacological inhibitor of ERK aggravated the 4-OHE{sub 2}-induced cytotoxicity, supporting the pivotal role of ERK in protecting against catechol estrogen-induced oxidative cell death.

Chen Zhihua [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Na, Hye-Kyung [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Hurh, Yeon-Jin [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Surh, Young-Joon [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of)]. E-mail: surh@plaza.snu.ac.kr

2005-10-01T23:59:59.000Z

83

ATF3 Plays a Key Role in Kdo 2-Lipid A-Induced TLR4- Dependent Gene Expression via NF-kB Activation  

E-Print Network (OSTI)

Background: Activating transcription factor 3 (ATF3) is a negative regulator of proinflammatory cytokine expression in macrophages, and ATF3 deficient mice are more susceptible to endotoxic shock. This study addresses the role of ATF3 in the Kdo 2-Lipid A-induced Toll-like receptor 4 (TLR4) signaling pathway in mouse embryonic fibroblasts (MEF). Kdo 2-Lipid A upregulates ATF3 expression in wild type MEF cells and induces both nuclear factor kappa B (NF-kB) and c-Jun N-terminal kinase (JNK) activation via the TLR4 signaling pathway, while neither of these pathways is activated in ATF3-/- MEF cells. Interestingly, in contrast to Kdo 2-Lipid A, the activation of both NF-kB and JNK by TNF-a was normal in ATF3-/- MEF cells. Methodology/Principal Findings: We found that several genes were dramatically upregulated in ATF3+/+ MEF cells in response to Kdo2-Lipid A treatment, while little difference was observed in the ATF3-/- MEF cells. However, we also found that the signal intensities of IkBf in ATF3-/- MEF cells were substantially higher than those in wild type MEF cells upon microarray analyses, and upregulated IkBf expression was detected in the cytosol fraction. Conclusions/Significance: Our findings indicate that ATF3 deficiency affects Kdo 2-Lipid A-induced TLR4 signaling pathways in MEF cells, that it may upregulate IkBf expression and that the high levels of IkBf expression in ATF3-/- cells disrupts Kdo2-Lipid A-mediated signaling pathways.

Eun-young Kim; Hye Young Shin; Joo-young Kim; Dong-gun Kim; Yong-min Choi; Dong-kwon Rhee; You-sun Kim; Sangdun Choi

2010-01-01T23:59:59.000Z

84

The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-{kappa}B and I{kappa}B-{gamma}: Implications for NF-{kappa}B-mediated signal transduction  

SciTech Connect

The NFKB1 gene encodes three proteins of the NF-{kappa}/Rel and I{kappa}B families: p105, p50, and (in mouse) I{kappa}B-{gamma}. We determined the complete genomic structure of human NFKB1. NFKB1 spans 156 kb and has 24 exons with introns varying between 40,000 and 323 bp in length. Although NFKB2, which encodes p100 and p52, also has 24 exons and has a comparable exon-intron structure, it is 20 times shorter than NFKB1. We propose that the long size of NFKB1 is important for transient activation of NF-{kappa}B complexes containing p50. I{kappa}B-{gamma} corresponds to the carboxyl-terminal half of p105. DNA sequence analysis showed that the 3{prime}-end of human intron 11 and the 5{prime}-end of exon 12 of NFKB1 are colinear with the 5{prime}-untranslated region of mouse I{kappa}B-{gamma} cDNA. I{kappa}B-{gamma} is thus likely to be generated by transcription starting within intron 11 and not by alternative splicing of the mouse mRNA encoding p105 and p50. 71 refs., 5 figs., 1 tab.

Heron, E.; Deloukas, P.; van Loon, A.P.G.M. [F. Hoffmann-La Roche Limited, Basel (Switzerland)] [F. Hoffmann-La Roche Limited, Basel (Switzerland)

1995-12-10T23:59:59.000Z

85

Numerical investigation of the pulsed NF3 + H2 chemical laser using a model which includes rotational relaxation and semi-classical laser equations  

DOE Green Energy (OSTI)

Waveforms and population distributions have been calculated by a numerical model and compared with experiment for an electric-discharge-initiated, pulsed NF$sub 3$ + H$sub 2$ chemical laser. The model treats each vibrational- rotational state separately, allowing rotational relaxation between adjacent states as well as vibrational relaxation and lasing according to P-branch selection rules. Calculated waveforms agree with experiment and show several features not seen when rotational equilibrium is assumed: simultaneous lasing on many transitions, cascade behavior, spikes due to laser relaxation oscillations, non-Boltzmann rotational distributions, and ''hole burning'' in the population distributions. The calculations give insight into the physical phenomena governing the shape and duration of the waveforms. The effect of varying certain parameters, relaxation rates, temperature, pressure, and diluents, is studied. Best fit to experimental waveforms is obtained when the rotational relaxation rate and collisional line broadening rate are approximately equal at about 10 times the hard sphere collision rate. The IXION computer code, developed for these calculations, is described in detail. In addition, an analytic model is presented which accounts for major features of the total (all transitions) output waveform of the laser assuming rotational equilibrium, a steady state laser model, and constant temperature. A second computer code, MINOTAR, was developed as a general purpose chemical kinetics code. It verifies the analytic model and extends the results to adiabatic reactions where the temperature varies, and can yield waveforms using the assumptions of rotational equilibrium and a steady state laser. The MINOTAR code, being general, can also be used for chemical kinetics problems such as air pollution and combustion. (auth)

Creighton, J.R.

1975-09-01T23:59:59.000Z

86

Numerical investigation of the pulsed NF3 + H2 chemical laser using a model which includes rotational relaxation and semi-classical laser equations  

SciTech Connect

Waveforms and population distributions have been calculated by a numerical model and compared with experiment for an electric-discharge-initiated, pulsed NF$sub 3$ + H$sub 2$ chemical laser. The model treats each vibrational- rotational state separately, allowing rotational relaxation between adjacent states as well as vibrational relaxation and lasing according to P-branch selection rules. Calculated waveforms agree with experiment and show several features not seen when rotational equilibrium is assumed: simultaneous lasing on many transitions, cascade behavior, spikes due to laser relaxation oscillations, non-Boltzmann rotational distributions, and ''hole burning'' in the population distributions. The calculations give insight into the physical phenomena governing the shape and duration of the waveforms. The effect of varying certain parameters, relaxation rates, temperature, pressure, and diluents, is studied. Best fit to experimental waveforms is obtained when the rotational relaxation rate and collisional line broadening rate are approximately equal at about 10 times the hard sphere collision rate. The IXION computer code, developed for these calculations, is described in detail. In addition, an analytic model is presented which accounts for major features of the total (all transitions) output waveform of the laser assuming rotational equilibrium, a steady state laser model, and constant temperature. A second computer code, MINOTAR, was developed as a general purpose chemical kinetics code. It verifies the analytic model and extends the results to adiabatic reactions where the temperature varies, and can yield waveforms using the assumptions of rotational equilibrium and a steady state laser. The MINOTAR code, being general, can also be used for chemical kinetics problems such as air pollution and combustion. (auth)

Creighton, J.R.

1975-09-01T23:59:59.000Z

87

High-loop perturbative renormalization constants for Lattice QCD (II): three-loop quark currents for tree-level Symanzik improved gauge action and n_f=2 Wilson fermions  

E-Print Network (OSTI)

Numerical Stochastic Perturbation Theory was able to get three- (and even four-) loop results for finite Lattice QCD renormalization constants. More recently, a conceptual and technical framework has been devised to tame finite size effects, which had been reported to be significant for (logarithmically) divergent renormalization constants. In this work we present three-loop results for fermion bilinears in the Lattice QCD regularization defined by tree-level Symanzik improved gauge action and n_f=2 Wilson fermions. We discuss both finite and divergent renormalization constants in the RI'-MOM scheme. Since renormalization conditions are defined in the chiral limit, our results also apply to Twisted Mass QCD, for which non-perturbative computations of the same quantities are available. We emphasize the importance of carefully accounting for both finite lattice space and finite volume effects. In our opinion the latter have in general not attracted the attention they would deserve.

Brambilla, Michele

2013-01-01T23:59:59.000Z

88

The human transcription factor CP2 (TFCP2), a component of the human {gamma}-globin stage selector protein, maps to chromosome region 12q13 and is within 250 kb of the NF-E2 gene  

SciTech Connect

The transcription factor CP2{sup 2} has been shown to bind to several cellular and viral promoters as a homodimer. More recently, we have demonstrated that CP2 can form a heterodimer with a 45-kDa partner protein to form the stage selector protein complex (SSP). This complex binds to a proximal {gamma}-globin promoter regulatory element, the stage selector element (SSE), which appears to be involved in the competitive silencing of the {beta}-gene in the fetal stage of erythropoiesis. Similar SSP-like binding sites have been identified in the {beta}-globin promoter and regulatory elements of the {beta}-globin locus control region (LCR). The importance of the SSP complex is further emphasized by the fact that the chicken stage selector protein, NF-E4, which has been implicated in the competitive silencing of the chicken {epsilon}-globin gene, is the avian homologue of CP2. The purpose of this study is to map human CP2 genomically and define its relationship to previously identified loci. 9 refs., 1 fig.

Cunningham, J.M.; Tran, N.; Valentine, M. [St. Jude Children`s Research Hospital, Memphis, TN (United States)] [and others

1995-11-20T23:59:59.000Z

89

Mechanical Properties of Advanced NF616 Steel  

Science Conference Proceedings (OSTI)

... of TIG Welded and Laser-surface Melted SUS 304 for Nuclear Power Plants ... Statistics of Grain Boundary Crystallography in Surrogates for Oxide Nuclear...

90

Beam Loading Computation for the IDS-NF FFAG  

SciTech Connect

I accumulate the information we have for the current baseline design for a neutrino factory to determine the maximum current we can expect at the final FFAG accelerating stage. I then determine the energy extracted from the RF cavities in the FFAG, and from that determine how much time there must be between bunch trains to restore the energy to the RF cavities so that each bunch train has the same energy at the storage ring. I also estimate the amount of energy variation from the head to the tail of the bunch train.

Berg, J.S.

2011-10-01T23:59:59.000Z

91

CMRR-NF Supplemental EIS Scoping Comments | National Nuclear...  

National Nuclear Security Administration (NNSA)

Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management...

92

QCD THERMODYNAMICS WITH NF=2+1 NEAR THE CONTINUUM LIMIT AT REALISTIC QUARK MASSES.  

Science Conference Proceedings (OSTI)

We report on our study of QCD thermodynamics with 2 + 1 flavors of dynamical quarks. In this proceeding we present several thermodynamic quantities and our recent calculation of the critical temperature. In order to investigate the thermodynamic properties of QCD near the continuum limit we adopt improved staggered (p4) quarks coupled with tree-level Symanzik improved glue on N{sub t} = 4 and 6 lattices. The simulations are performed with a physical value of the strange quark mass and light quark masses which are in the range of m{sub q}/m{sub s} = 0.05 - 0.4. The lightest quark mass corresponds to a pion mass of about 150 MeV.

UMEDA, T.

2006-07-23T23:59:59.000Z

93

Centr um voor Wi skunde en I nf or mati ca Modelling, AnalysisandSimulation  

E-Print Network (OSTI)

. . . . . . . . . . . . . . . . . . . . . . . . . . 31 iii #12;Contents CAFE Final Report Volume II III Protocols 33 6 Notation and De nitions 35 6.1 and Simulation CAFE project _ Final report volume II Secure protocols and architecture Edited by A. Bosselaers, R;CAFE Project - Final Report Volume II Secure Protocols and Architecture Edited by A. Bosselaers, R

Schoenmakers, Berry

94

e its go right to the heart nf the basis on which  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

gas at the low- est cost-of-service to U.S. consumers-probably below the cost of imported oil and substantially below the costs of other fuel alter- natives. The average price of...

95

Effects of water chemistry on NF/RO membrane structure and performance  

E-Print Network (OSTI)

dioxane. 3.4. Water chemistry: Concentration, pH,4.3.1. Effect of water chemistry on membrane water4.3.2. Effect of water chemistry on EG rejection. ..

Mo, Yibing

2013-01-01T23:59:59.000Z

96

Review of NF-IDS Targets Work Programme Status C. Densham, RAL, 17 November 2009  

E-Print Network (OSTI)

and services ? e) Cost of mercury system ? f) Cost of remote handling systems including shielding required ? g implications for TS shielding CJD, OC, PL (RAL) 4.3.7 Investigate remote handling concepts and cost Dump iv. Time to repair/replace target system, Remote Handling complexity v. Maintenance intervals vi

McDonald, Kirk

97

A Combined NF-IDS and EUROnu Targets Work Programme Chris Densham, Marco Zito, Harold Kirk  

E-Print Network (OSTI)

i. Target system active volume ­ civil engineering, shielding and building costs ii. Remote handling and services e) Cost of mercury system f) Cost of remote handling systems including shielding required g) Any implications for TS TBD #12;shielding 4.3.10 Investigate remote handling concepts, reliability and cost RE

McDonald, Kirk

98

Effects of water chemistry on NF/RO membrane structure and performance  

E-Print Network (OSTI)

water by GAC adsorption, Desalination, 210 (2007) 215-224. [with strong oxidants, Desalination, 176 (2005) 37-45. [49]water RO membranes, Desalination, 235 (2009) 44-57. [19] G.

Mo, Yibing

2013-01-01T23:59:59.000Z

99

Heavy Quark Physics in Nf = 2 QCD ? CP-PACS Collaboration:  

E-Print Network (OSTI)

We present a preliminary analysis of the heavy-heavy spectrum and heavy-light decay constants in full QCD, using a tadpole-improved SW quark action and an RG-improved gauge action on a 16 3 32 lattice with four sea quark masses corresponding to m?/m? ? 0.8, 0.75, 0.7, 0.6 and a ?1 ? 1.3 GeV. We focus particularly on the effect of sea quarks on these observables. 1.

unknown authors

1998-01-01T23:59:59.000Z

100

Insights from reconstructing cellular networks in transcription, stress, and cancer  

E-Print Network (OSTI)

M. & Ghosh, S. Crosstalk in NF-kB signaling pathways. Natcomprehensive characterization of NF-kB family DNA binding.12 CHAPTER 1 NF-kB

Ke, Eugene Yunghung; Ke, Eugene Yunghung

2012-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

DOI: 10.1126/science.1164265 , 407 (2009);324Science  

E-Print Network (OSTI)

). Similarly, single nucleotide differences in NF-kB binding sequences determine cofactor specificity for NF-kB

Yamamoto, Keith

102

CtjNf.~1'-1'6....r .:tt33 J C7b/(j7/IS-  

E-Print Network (OSTI)

University Princeton, New Jersey 08540 (Submitted to the XVIII Conf. in High-Energy Physics, Tbilisi, USSR

McDonald, Kirk

103

On the Use of Thermal NF3 as the Fluorination and Oxidation Agent in Treatment of Used Nuclear Fuels  

SciTech Connect

This paper presents results of our investigation on the use of nitrogen trifluoride as the fluorination or fluorination/oxidation agent for use in a process for separating valuable constituents from used nuclear fuels by employing the volatility of many transition metal and actinide fluorides. Nitrogen trifluoride is less chemically and reactively hazardous than the hazardous and aggressive fluorinating agents used to prepare uranium hexafluoride and considered for fluoride volatility based nuclear fuels reprocessing. In addition, nitrogen trifluorides less aggressive character may be used to separate the volatile fluorides from used fuel and from themselves based on the fluorination reactions temperature sensitivity (thermal tunability) rather than relying on differences in sublimation/boiling temperature and sorbents. Our thermodynamic calculations found that nitrogen trifluoride has the potential to produce volatile fission product and actinide fluorides from candidate oxides and metals. Our simultaneous thermogravimetric and differential thermal analyses found that the oxides of lanthanum, cerium, rhodium, and plutonium fluorinated but did not form volatile fluorides and that depending on temperature volatile fluorides formed from the oxides of niobium, molybdenum, ruthenium, tellurium, uranium, and neptunium. We also demonstrated near-quantitative removal of uranium from plutonium in a mixed oxide.

Scheele, Randall D.; McNamara, Bruce K.; Casella, Andrew M.; Kozelisky, Anne E.

2012-05-01T23:59:59.000Z

104

Journal of Membrane Science 256 (2005) 134142 Characterization of novel acid-stable NF membranes before and after  

E-Print Network (OSTI)

studies, artificial aquifer storage and recovery, waterflood surveillance, gas production and CO2. Brady, C. L. V. Aiken, and J. E. Seib- ert, 2007, The 4D mictogravity method for waterflood surveillance

Freger, Viatcheslav "Slava"

105

QCD thermodynamics with $N_f=2+1$ near the continuum limit at realistic quark masses  

E-Print Network (OSTI)

We report on our study of QCD thermodynamics with 2+1 flavors of dynamical quarks. In this proceeding we present several thermodynamic quantities and our recent calculation of the critical temperature. In order to investigate the thermodynamic properties of QCD near the continuum limit we adopt improved staggered (p4) quarks coupled with tree-level Symanzik improved glue on $N_t=4$ and 6 lattices. The simulations are performed with a physical value of the strange quark mass and light quark masses which are in the range of $m_q/m_s=0.05-0.4$. The lightest quark mass corresponds to a pion mass of about 150 MeV.

Takashi Umeda

2006-10-03T23:59:59.000Z

106

Burned Area Emergency Response (BAER) Assessment FINAL Specialist Report GEOLOGIC HAZARDS Station Fire, Angeles N.F.  

E-Print Network (OSTI)

Three USFS BAER Team geologists assessed increased risks from geologic hazards within the 161,000 acre Station Fire. Watershed response to moderate and high severity burned areas will depend on storm intensity and duration, but is likely to be threatening to life, property and natural resources, and costly. Even small storms have a high to severe relative hazard rating for dangerous debris flows across most of the burned area. Most treatments to reduce debris flow risk were deemed not feasible, not effective, and cost prohibitive. Rockfall, debris slides and dry ravel will add additional hazard and sediment bulk to flood flows. Debris basins will fill quickly, and could overtop and damage downstream communities and infrastructure. Debris storage sites are lacking. Abandoned mines are exposed and add additional hazards. Treatment options are few, and warning systems and public education are critical.

Jerry Degraff Geologist; Sierra N. F; Jonathan Yonni; Schwartz Geologist; Angeles N. F

2009-01-01T23:59:59.000Z

107

Low level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts  

E-Print Network (OSTI)

Despite over forty years of investigation on low-level light therapy (LLLT), the fundamental mechanisms underlying photobiomodulation remain unclear. In this study, we isolated murine embryonic fibroblasts (MEF) from ...

Hamblin, Michael R.

108

NMR studies of the transcriptional inhibitor I kappa B alpha and its interaction with the transcription factor NF kappa B  

E-Print Network (OSTI)

correction of random coil NMR chemical shifts. J Am Chem Socproteins by multidimensional NMR. Biochemistry Bax, A. ,ensemble interpretation of NMR dipolar couplings without

Cervantes, Carla F.

2010-01-01T23:59:59.000Z

109

KT McDonald IDS-NF Plenary Meeting (Glasgow) Apr 19, 2012 1 The High-Power-Target System  

E-Print Network (OSTI)

Cryogenics Diagnostics Controls and Interlocks Health and Safety Mechanical Decommissioning Remote Handling and Hot Cells ######## UScaled from LBNE Buildings, tunnels and Infrastructure ######## Scaled from LBNE,405,475 1.06.06 - Target Utility Systems 10,730,099 1.06.07 - Remote Handling Systems 14,348,362 1

McDonald, Kirk

110

The non-canonical NFkappaB pathway modulates inflammatory signaling by the canonical NFkappaB pathway  

E-Print Network (OSTI)

Nomenclature Initial mM Location IkBa IkBa IkBa:NF-kBIkBa:NF-kB IkBa:IKKIkBa:IKK:NF-kB IkBa mRNA IkBb IkBb IkBb:NF-kB IkBb:NF-?B

Shih, Feng-Sheng

2011-01-01T23:59:59.000Z

111

Curcumin: A Review of Anti-Cancer Properties and Therapeutic Activity in Head & Neck Squamous Cell Carcinoma  

E-Print Network (OSTI)

Curcumin Inhibition of NF-kB activation, Suppression ofand other angionegic decreased NF-kB activation factors, Up-of transcription factor NF-kB is suppressed by curcumin (

Wilken, Reason; Veena, Mysore S; Wang, Marilene B; Srivatsan, Eri S

2011-01-01T23:59:59.000Z

112

Mitochondrial Protein Influx in Low-dose Radiation-mediated Radioprote...  

NLE Websites -- All DOE Office Websites (Extended Search)

radioprotection via activation of the prosurvival network of factor NF-kappa B (NF-kB). We have reported that blocking NF-kB activation is able to inhibit 10cGy x-ray-...

113

Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor  

E-Print Network (OSTI)

1 activity suppresses NF-kB-dependent gene transcription andinhibition suppresses NF-kB- dependent gene transcription inof PARP inhibitors to block NF-kB - mediated inflammatory

2012-01-01T23:59:59.000Z

114

The HB22.7 Anti-CD22 Monoclonal Antibody Enhances Bortezomib-mediated Lymphomacidal Activity in a Sequence Dependent Manner  

E-Print Network (OSTI)

the accumulation of NF-kB [3,4], increased ROS generation [via inhibition of NF-kB activation [29]. Interestingly,by bortezomib also inhibits NF-kB activation [3,4], which in

2011-01-01T23:59:59.000Z

115

Particulate Matter in Polluted Air May IncreaseBiomarkers of Inflammation in Mouse Brain  

E-Print Network (OSTI)

sample and unlabelled NF-kB consensus oligonu- cleotide, NSCendothelial cells: role of NF-kB activation. J Immunol 2001;EN, Krappmann D, Scheidereit C. NF-kB and the innate immune

Bondy, Stephen Bondy C

2005-01-01T23:59:59.000Z

116

Type I Interferon is Not Just for Viruses: Cytosolic Sensing of Bacterial Nucleic Acids  

E-Print Network (OSTI)

the nucleus and assemble with NF-kB and other transcriptionactivation of IRF3/7, NF-kB, and MAP kinases (Yoneyama andtype I IFNs primarily via NF-kB, which synergizes with other

Monroe, Kathryn McGee

2011-01-01T23:59:59.000Z

117

Advances in computational mass spectrometry : phosphoprotoemics and proteogenomics  

E-Print Network (OSTI)

and phosphorylation mediated NF-KB activiation. Four histoneto be activated, or relay the signal. In NF-KB signaling, atranscription factor (NF-KB) is held inactive outside the

Payne, Samuel Harris

2008-01-01T23:59:59.000Z

118

Discovery and characterization of the mechanisms of a vaccinia viral Bcl-2 homolog, F1L, on Inhibition of caspase-9 and NLRP1  

E-Print Network (OSTI)

a stably integrated NF-kB-driven secreted embryonic alkalineprior to VACV infection. NF-kB activation in THP-1-Bluecells (ATCC; InvivoGen), NF-kB activation was evaluated by

Yu, Chi Wang

2010-01-01T23:59:59.000Z

119

Mechanisms of regulation in the interferon factor 3 (IRF- 3) pathway  

E-Print Network (OSTI)

gene induction, whereas NF-kB- dependent gene inductioncytokines through the NF-kB pathway 4 , hinting at theprotein) and leads to NF-kB activation 2 . This pathway is

Limmer, Kirsten

2008-01-01T23:59:59.000Z

120

Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?  

E-Print Network (OSTI)

and one of the key factors implicated has been NF-kB [78].Nuclear translocation of NF-kB is associated withSong et al. inhibited NF-kB selectively in the endothelium

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Effects of melatonin and age on gene expression in mouseCNS using microarray analysis  

E-Print Network (OSTI)

gene contains an activation site for NF-kB (Cowland et al. ,and levels of activated NF-kB increase in murine cortex withThus, increased levels of NF-kB activation in the aged brain

Bondy, Stephen Bondy C

2007-01-01T23:59:59.000Z

122

Sumoylation strategies in regulated repression by nuclear receptors and in function of tumor metastasis suppressor genes  

E-Print Network (OSTI)

links gene expression by NF-kB and ?-amyloid precursorinteracts with and inhibits NF-kB in human colon and breastby KAI1. Since KAI1 is a NF-kB target gene, its message

Cai, Ling

2008-01-01T23:59:59.000Z

123

Activation of nucleic acid-sensing Toll-like receptors requires cleavage by endolysosomal proteases: a mechanism to avoid autoimmunity  

E-Print Network (OSTI)

a) RAW cells expressing an NF-kB luciferase reporter wereTRIF to induce production of NF-kB elicited transcripts andand a plasmid encoding an NF-kB luciferase reporter (with 5

Ewald, Sarah Elisabeth

2010-01-01T23:59:59.000Z

124

Self/Non-self Discrimination by Toll-like Receptor 9  

E-Print Network (OSTI)

cells stably expressing a NF-kB luciferase reporter and thewith LPS or CpG. Bottom, NF-kB luciferase activity measuredcells stably expressing a NF-kB luciferase reporter and TLR9

Mouchess, Maria Luz

2011-01-01T23:59:59.000Z

125

Plant and animal sensors of conserved microbial signatures.  

E-Print Network (OSTI)

a nuclear factor kB (NF-kB) re- sponse, is a key transducerof one human TLR induced NF-kB activation in mammaliansee SOM). Plants do not have NF-kBrelated transcrip- tion

Ronald, Pamela C; Beutler, Bruce

2010-01-01T23:59:59.000Z

126

Molecular mechanisms of ligand-dependent repression by the estrogen receptor and derepression by inflammatory signaling  

E-Print Network (OSTI)

links gene expression by NF-kB and b-amyloid precursorsuch as Receptor Activator of NF-kB (RANK), p75 neurotrophinby the p50 ho- modimer of NF-kB DNA binding factors by

Bourk, Eliot Michael

2010-01-01T23:59:59.000Z

127

Protein Kinase CK2 Regulates Cytoskeletal Reorganization during Ionizing Radiation-Induced Senescence of Human Mesenchymal Stem Cells  

E-Print Network (OSTI)

cytokines/chemokines are NF- kB responsive genes. These dataand suggested the possibility of NF-kB activation leadingto secretion of NF-kB responsive chemokines. Cytoskeleton

Wang, Daojing

2010-01-01T23:59:59.000Z

128

Evolution of the Oligopeptide Transporter (OPT) family  

E-Print Network (OSTI)

evaluation. Name Publication NF-kB Tian et al. 2005a 173expressed mutant IkB blocking NF-kB signaling (labeled based selection in (a) NF-kB dataset, (b) ALL dataset, (c)

Gomolplitinant, Kenny Matee

2010-01-01T23:59:59.000Z

129

Toll-like Receptor Signaling and its Effects on Microbial Pathogenesis  

E-Print Network (OSTI)

of transcription factors (NF-kB, AP-1, IRFs) that coordinatestably expressing an NF-kB- luciferase reporter construct.in robust induction of NF-kB, which we attributed to

Arpaia, Nicholas

2011-01-01T23:59:59.000Z

130

Sample-Specific Cancer Pathway Analysis Using PARADIGM  

E-Print Network (OSTI)

cation of response to QNZ (an NF-KB inhibitor) in the breastfor the combination of QNZ (an NF-KB inhibitor) and E2F3.studies have shown that NF-KB may activate E2F family

Benz, Stephen Charles

2012-01-01T23:59:59.000Z

131

Trichoepithelioma  

E-Print Network (OSTI)

that negatively regulates NF-kB activation by TNFR familycomponent proteins in the NF-kB and JNK signaling pathways.regulate the cytokine-induced NF-kB pathway for cellular

Johnson, Hillary; Robles, Mirin; Kamino, Hideko; Walters, Ruth F; Lee, Arnold; Sanchez, Miguel

2008-01-01T23:59:59.000Z

132

Computational tools based on energy landscape theory to predict structurally diverse ensembles of transcription factors  

E-Print Network (OSTI)

E. (2004) Thermodynamics and kinetics of the nf-kb/ikband nf-kb/dna interactions, Biophysical Journal 86, 513a. [

Ltzer, Joachim

2007-01-01T23:59:59.000Z

133

Metabolic Regulation by Lipid Activated Receptors  

E-Print Network (OSTI)

of iKB, which limits Nf-KB signaling(31, 32). PPAR ?VCAM expression through nf-kb and AP1 signaling when taken

Ruby, Maxwell A.

2010-01-01T23:59:59.000Z

134

A High-throughput Screening Approach Identifies Selective Regulators of Il12b Transcription  

E-Print Network (OSTI)

TLR4, in contrast to NF-kB and AP-1, whose activities aresignaling pathways, such as NF-kB and MAP kinase pathways,

Doty, Kevin Richard

2012-01-01T23:59:59.000Z

135

Analysis of Alzheimer's disease severity across brain regions by topological analysis of gene co-expression networks  

E-Print Network (OSTI)

in CF airways Transcription NF-kB signalling pathways Immunesilencing NGF activation of NF-kB EC-MTG Cytoskeleton

Ray, Monika; Zhang, Weixiong

2010-01-01T23:59:59.000Z

136

Shadow Enhancers Provide Precision and Robustness for the Patterning of the Precellular Drosophila Embryo  

E-Print Network (OSTI)

related to mammalian NF-kB. Dorsal controls DV patterningfactor related to mammalian NF-kB (Rushlow et al. 1989; Roth

Perry, Michael W.

2011-01-01T23:59:59.000Z

137

Structural Studies of Calcium/Calmodulin Depenedent Protein Kinase II Activation  

E-Print Network (OSTI)

activation. For example, NF-kB and Ras have been shown toet al. , 2005), and the NF-kB pathway (Dolmetsch et al. ,

Chao, Luke H.

2010-01-01T23:59:59.000Z

138

Pancreatitis and pancreatic cancer in two large pooled casecontrol studies  

E-Print Network (OSTI)

released during pancreatitis, NF-KB, IL-8, COX-2, and TNF-54]. The involvement of NF-KB is of particular interest as

Bracci, Paige M.; Wang, Furong; Hassan, Manal M.; Gupta, Samir; Li, Donghui; Holly, Elizabeth A.

2009-01-01T23:59:59.000Z

139

Anakinra-responsive lichen planus in a woman with Erdheim-Chester disease: a therapeutic enigma  

E-Print Network (OSTI)

cyclosporine A on TLRA/NF-kB signaling pathway activation inof the pro-inflammatory, NF-kB-dependent cytokines: TNF-

Cohen, Philip R; Kurzrock, Razelle

2014-01-01T23:59:59.000Z

140

Conference Highlights of the 15th International Conference on Human Retrovirology: HTLV and Related Retroviruses,4-8 June 2011, Leuven, Gembloux, Belgium  

E-Print Network (OSTI)

subcellular localization and NF-kB activation. RetrovirologyTax sumoylation in Tax-induced NF-kB activation in T cells.

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

NK1 (substance P) receptor  

E-Print Network (OSTI)

nuclear factor- kappaB (NF-kB) and leads to the productionits expression is controlled by NF-kB (Patel et al. 2005;

Goldsmith, Laura E; Kwatra, Madan M

2012-01-01T23:59:59.000Z

142

Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress  

E-Print Network (OSTI)

Signaling pathway: Nrf2 MAPK NF-kB Genetic response:ARE AP NF-kB Mitochondrial perturbation PT pore Figure 4

Araujo, Jesus A; Nel, Andre E

2009-01-01T23:59:59.000Z

143

Epidermal growth factor (EGF)-mediated DNA-binding activity of AP-1 is attenuated in senescent human epidermal keratinocytes  

E-Print Network (OSTI)

of microtubes activated NF-kB. J Cell Biol 1995: 128: 1111regulation of wound healing? NF-kB activation in cultured

Shi, B; Isseroff, R R

2005-01-01T23:59:59.000Z

144

Host factor regulation of Toxoplasma gondii growth and differentiation  

E-Print Network (OSTI)

has been shown that the NF-kB subunit p65 is phosphorylatedas a consequence of NF-kB signaling upon parasite

Weilhammer, Dina

2010-01-01T23:59:59.000Z

145

Z. Geomorph. N.F. Suppl.-Vol.146 235-251 Berlin Stuttgart November 2006 Geologic Impacts of the 2004 Indian OceanTsunami on Indonesia,  

E-Print Network (OSTI)

of the 2004 Indian OceanTsunami on Indonesia, Sri Lanka, and the Maldives Bruce M. Richmond, Bruce E in the eastern Indian Ocean near northern Sumatra, Indonesia.The resulting tsunami was measured globally and had.1) with an epicenter located under the seafloor in the eastern Indian Ocean near northern Sumatra, Indonesia

146

PI3 Kinase Signals BCR-Dependent Mature B Cell Survival  

E-Print Network (OSTI)

and BAFF-R signal B cellsurvival? UponBAFFengagement,theBAFF-R signalsmainly through the alternative NF-kB can activate the canonical NF-kB signaling pathway and mature B cells require canonical NF-kB signals) to propose a model in which mature B cell survival is based on an NF-kB-mediated crosstalk between BCR

147

Presence of Terminal EPIYA Phosphorylation Motifs in Helicobacter pylori CagA Contributes to IL-8 Secretion,  

E-Print Network (OSTI)

Ba phosphorylation and confirmed CagA involvement in NF-kB activation. Furthermore, we observed that presence of EPIYA-C functional phosphorylation motifs contributed to NF-kB activation. NF-kB upstream signaling-/- mouse embryonic fibroblasts (MEFs) failed to induce NF-kB activity, unlike the respective control MEFs

148

S:\VM3\RX97\TBL_LIST.WPD  

U.S. Energy Information Administration (EIA) Indexed Site

Million U.S. Households, 1997 Housing Unit Characteristics RSE Column Factor: Total Four Most Populated States RSE Row Factors New York California Texas Florida 0.4 1.1 1.1 1.2 1.7 Total .............................................................. 101.5 6.8 11.5 7.0 5.9 NF Census Region and Division Northeast ..................................................... 19.7 6.8 -- -- -- NF New England ............................................. 5.3 Q -- -- -- NF Middle Atlantic ........................................... 14.4 6.8 -- -- -- NF Midwest ....................................................... 24.1 -- -- -- -- NF East North Central ..................................... 16.9 -- -- -- -- NF West North Central .................................... 7.2 -- -- -- -- NF South ...........................................................

149

Plasmacytoid Dendritic Cells Are Crucial for the Initiation of Inflammation  

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downstream signaling pathways, in which the activation of the transcription factor nuclear factor kB (NF-kB) results in the production of proinflammatory cytokines, whereas the acti- vation of inhibitor of NF-kB (Ik

Gleeson, Joseph G.

150

Molecular Cell STAT3 Activation of miR-21 and miR-181b-1  

E-Print Network (OSTI)

cells via a positive feedback loop involving NF-kB, Lin28, let-7, and IL-6. We identify differentially, respectively, inhibit PTEN and CYLD tumor suppressors, leading to increased NF-kB activity required to maintain

Bulyk, Martha L.

151

Molecular Cell OTULIN Restricts Met1-Linked Ubiquitination  

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of IkBa, leading to nuclear translocation of nuclear factor kB (NF-kB) transcription factors. Together with transcription factors activated by MAP kinases, NF-kB promotes expression of genes that orchestrate

Komander, David

152

10.1101/gad.1936910Access the most recent version at doi: 2010 24: 1533-1545Genes Dev.  

E-Print Network (OSTI)

al. 2009). Studies with NF-kB (Leung et al. 2004) and glucocorticoid receptor (Meijsing et al. 2009- coid receptor and NF-kB affects the regulatory output of the bound complex, suggesting that small

153

Feiqiao Brian Yu 2012.03.16  

E-Print Network (OSTI)

individual cell (5). Another example deals with the study of NF-kB expression in mouse fibroblast cells (5). (B) Contrary to previous studies, NF-kB expression in mouse fibroblast cells occur digitally

Bejerano, Gill

154

Molecular mechanisms integrating genetic and calcium activity-dependent neurotransmitter specification  

E-Print Network (OSTI)

adhesion molecule vii NFAT NF-kB NFY Ngn1/2 NMDA NT p-cJuncontrast, activation of the NF-kB transcription factor by Ca

Kurtz, Lisa Miriam

2010-01-01T23:59:59.000Z

155

Worksheet  

U.S. Energy Information Administration (EIA) Indexed Site

of",6,5,"Aliant Energy Corp.","NF",1,,,30,30 8245,"Hastings City of",6,6,"Mid America Energy Co.","NF",14,,,561,561 8245,"Hastings City of",6,7,"Manitoba Hydro...

156

Worksheet  

U.S. Energy Information Administration (EIA) Indexed Site

Energy Trading","NF",270,,,15700,15700 9130,"Hutchinson Utilities Comm",6,6,"Manitoba Hydro Power","NF",299,,,4535,4535 9130,"Hutchinson Utilities Comm",6,7,"MidAmerica...

157

Dynamic Chromatin Localization of Sirt6 Shapes Stress-and Aging-Related Transcriptional Networks  

E-Print Network (OSTI)

control. Sirt6 can interact with the stress-responsive transcription factor NF-kB and regulate some NF-kB upon stress-signaling. The majority of genes bound by NF-kB subunit RelA recruit Sirt6, and dynamic of NF-kB signaling in stress response and aging. Citation: Kawahara TLA, Rapicavoli NA, Wu AR, Qu K

Quake, Stephen R.

158

A new indicator for breast cancer relapse identified http://www.eurekalert.org/pub_releases/2012-06/idm-ani061912.php[19/06/2012 16:38:11  

E-Print Network (OSTI)

the signalling of a protein complex called NF-kB, which is related to tumour progression. The activation of NF-kB, although the NF-kB complex is an essential requirement for it to remain active chronically-3-3 sigma and/or the activation of NF-kB in tumour cells as a factor in prognosis and diagnosis, as well

Foissac, Sylvain

159

A New Family of Synthetic Diterpenes that Regulates Cytokine Synthesis by Inhibiting IkBa  

E-Print Network (OSTI)

factors, col- lectively referred to as nuclear factor-kappa B (NF-kB).[4] In its resting state, NF-kB- flammatory stimuli induce phosphorylation of IkB leading to dissociation of NF-kB from its inhibitors. Once separated from IkB, NF-kB translocates into the nucleus, binds to the target DNA, and initiates gene

Theodorakis, Emmanuel

160

Molecular Cell Crystal Structures of the TRAF2: cIAP2  

E-Print Network (OSTI)

. They are crit- ical for canonical and noncanonical NF-kB signaling pathways. Here, we report the crystal-associated factors (TRAFs) in NF-kB and MAP kinase activation pathways in the signaling of multiple receptor families and the noncanon- ical NF-kB signaling pathways. In the noncanonical NF-kB signaling pathway, TRAF2 and cIAP1

Wu, Hao

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
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to obtain the most current and comprehensive results.


161

Molecular discrimination of structurally equivalent Lys63-linked and linear polyubiquitin chains  

E-Print Network (OSTI)

: ubiquitin linkage; deubiquitinase; ubiquitin binding domain; NF-kB signalling; TAK1/IKK/NEMO/NF-kB EMBO (inhibitor of kB kinase) pathway to nuclear factor-kappaB (NF-kB; Adhikari et al, 2007). TAK1 has been shown leads to the activation of IKK by TAK1 and subsequent NF-kB signalling (Adhikari et al, 2007

Komander, David

162

letters to nature 90 NATURE |VOL 406 |6 JULY 2000 |www.nature.com  

E-Print Network (OSTI)

that GSK-3b function is required for the NF-kB-mediated anti-apoptotic response to TNF-a. Our data also . Immunoblotting was carried out with I-kB-a (polyclonal, New England Biolabs), p65 NF-kB (polyclonal, Santa Cruz of either NF-kB-speci®c oligonu- cleotide probe containing two tandem NF-kB-binding sites (59

Davis, Trisha N.

163

To explore further the anti-inflammatory mech-anisms of PGRN and Atsttrin, we investigated  

E-Print Network (OSTI)

the role of PGRN and Atsttrin in the TNFa- induced activation of IKK (IkB kinase)­IkB­ NF-kB (nuclear). Treatment of BMDMs with rhPGRN or Atsttrin impaired TNFa-induced NF-kB nu- clear translocation, NF-kB binding to the IkBa promoter, and activation of gene expression by NF-kB (Fig. 6, C to F) (33). rh

164

DOI: 10.1126/science.1200840 , 484 (2011);332Science  

E-Print Network (OSTI)

activation of IKK (IkB kinase)­IkB­ NF-kB (nuclear factor kB) signaling. rhPGRN and Atsttrin blocked TNFa-induced NF-kB nu- clear translocation, NF-kB binding to the IkBa promoter, and activation of gene expression by NF-kB (Fig. 6, C to F) (33). rhPGRN and Atsttrin also inhibited the TNFa-induced phosphoryla- tion

Gleeson, Joseph G.

165

A novel derivative of decursin, CSL-32, blocks migration and production of inflammatory mediators and modulates PI3K  

E-Print Network (OSTI)

and modulates PI3K and NF-kB activities in HT1080 cells Seung-Hee Lee*, Jee Hyun Lee{ , Eun-Ju Kim*, WonB), phosphorylation of p65 subunit of NF-kB (nuclear factor-kB) and nuclear translocation of NF-kB, which are required. Keywords: cytokine; inflammation; invasion; NF-kB; signal transduction 1. Introduction Decursin

Lee, Won-Ha

166

A chicken c-Rel-estrogen receptor chimeric protein shows conditional nuclear localization, DNA binding, transformation and transcriptional  

E-Print Network (OSTI)

and dierentiation will potentially dier depend- ing on the level of expression. Keywords: c-Rel; NF-kB, Gerondakis et al., 1996). Structurally, c-Rel belongs to a larger family of transcription factors, the Rel/NF-kB family, which also includes RelA, RelB, NF-kB1, NF-kB2, Dorsal, Dif, and Relish. All members

?urovec, Michal

167

Joel L.Pomerantz1 , Elissa M.Denny and  

E-Print Network (OSTI)

@caltech.edu NF-kB is a critical target of signaling downstream of the T cell receptor (TCR) complex, but how TCR sig- naling activates NF-kB is poorly understood. We have developed an expression cloning strategy that can identify catalytic and noncatalytic molecules that par- ticipate in different pathways of NF-kB

Baltimore, David

168

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative  

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Regulation of Noncanonical NF-kB Signaling Irving C. Allen,1 Justin E. Wilson,1 Monika Schneider,2 John D of NLR proteins, including NLRP12, inhibits the transcription factor NF-kB, although physiologic and disease-rele- vant evidence is largely missing. Dysregulated NF-kB activity is associated with colonic

169

Tea Pigments Inhibit the Production of Type 1 (TH1) and Type 2 (TH2) Helper T Cell Cytokines  

E-Print Network (OSTI)

been linked to their capacity to inhibit the activation of nuclear factor-kB (NF-kB), a transcription. The current study examines the requirement for NF-kB in the immunosuppressive effects mediated by tea require NF-kB for gene expression, such as interleukin-2 (IL-2) and interferon gamma (IFN g

Brand, Paul H.

170

Transcriptomic Analysis of Host Immune and Cell Death Responses Associated with the Influenza A Virus PB1-F2  

E-Print Network (OSTI)

-apoptotic properties of PB1-F2. Using a NF-kB luciferase adenoviral vector, we were able to quantify in vivo the implication of NF-kB in the inflammation mediated by the influenza virus infection; we found that PB1-F2 expression intensifies the NF-kB activity. Finally, we quantified the neutrophil recruitment within

Paris-Sud XI, Université de

171

Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene  

E-Print Network (OSTI)

. IKK3 acti- vates the nuclear factor-kappaB (NF-kB) path- way in both cell lines and breast cancers. These observations suggest a mechanism for NF-kB activation in breast cancer, implicate the NF-kB pathway

172

Melatonin Alters Age-Related Changes in Transcription Factors and Kinase Activation  

E-Print Network (OSTI)

not to alter the extent of NF-kB or AP-1 activation [14]. X-in the spleen, dietary a NF-kB activity (densitometic units)YC YM OC OM b NF-kB activity (densitometic units) Results

Bondy, Stephen Bondy C

2010-01-01T23:59:59.000Z

173

Molecular Cell, Volume 37 Supplemental Information  

E-Print Network (OSTI)

a gradual increase in NF-kB p65 nuclear concentration. (A) Wild-type HCT 116 cells were stimulated with increasing doses of TNF for 20 minutes. The nuclear translocation of NF-kB was assessed by immunofluorescence that increasing TNF doses induce uniformly increasing nuclear localization of NF-kB in the cell population. (C) We

Bulyk, Martha L.

174

sortium for sharing analysis results; C. Allen and H. McClure of the Yerkes Primate Center, Atlanta, and  

E-Print Network (OSTI)

when citing this paper. Achieving Stability of Lipopolysaccharide-Induced NF-kB Activation Markus W of the transcription factor NF-kB exhibit damped oscillatory behavior when cells are stimulated by tumor necrosis-like receptor 4 (TLR4) causes activation of NF-kB that requires two down- stream pathways, each of which when

Baltimore, David

175

Ah receptor represses acute-phase response gene expression without binding to its cognate response  

E-Print Network (OSTI)

Repression of the nuclear factor-kB (NF-kB) pathway has been extensively researched because of its pivotal NF-kB regulated-gene expression, especially acute-phase genes, such as serum amyloid A (Saa). Using of transcription factors, such as nuclear factor-kB (NF-kB), signal transducer and activator of transcription-3

Perdew, Gary

176

12. McDonald, J. C. & Whitesides, G. M. Poly(dimethylsiloxane) as a material for fabricating microfluidic devices. Accounts Chem. Res. 35, 491499 (2002).  

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macrophage NF-kB activation and contributes to the resolution of inflammation Toby Lawrence1 *, Magali Bebien and IKKb, and controls the activation of NF-kB transcription factors, which play a pivotal role in inflammation2 . Ample evidence indicates that IKKb mediates NF-kB activation in response to pro-inflamma- tory

Nizet, Victor

177

caspase-8 became enzymatically active after TCR stimulation (Fig. 3H and fig. S8G).  

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caspase-8 became enzymatically active after TCR stimulation (Fig. 3H and fig. S8G). Hence, NF-kB activation by antigen receptors requires enzyme activity of full-length caspase- 8. In the NF-kB-receptor signaling and as a selective signal transducer for NF-kB during the early genetic response to an antigen

Kharasch, Evan

178

Cell cycle and DNA damage response regulation by Spy1, and the intersection of FGFR and NFkappaB pathways  

E-Print Network (OSTI)

Bio-Rad). Quantification of NF-kB binding to the probe wasBio-Rad). The average NF-kB binding from three independentBio-Rad). Quantification of NF-kB binding to the probe was

McAndrew, Christopher William

2010-01-01T23:59:59.000Z

179

Acute liver injury upregulates microRNA-491-5p in mice, and its overexpression sensitizes Hep G2 cells for tumour necrosis factor-alpha-induced apoptosis.  

E-Print Network (OSTI)

expression of AFP, hsp-90 and NF-kB. Acknowledgements This90; miRNA, microRNA; NF-kB, nuclear factor-k B; siRNA, short90) and nuclear factor-kB (NF-kB). Overexpression of miRNA-

Wu, Jian; Zern, M A

2010-01-01T23:59:59.000Z

180

Control of Stochastic Gene Expression by Host Factors at the HIV Promoter  

E-Print Network (OSTI)

promoter contains cis- acting Sp1 and NF-kB elements that regulate gene expression via the recruitment lentivirus variants with mutations introduced in the Sp1 and NF-kB elements, we employed flow cytometry, m and reduction in the regulation of histone acetylation and deacetylation. Furthermore, the NF-kB sites exhibit

Schaffer, David V.

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

MEETING ABSTRACT Open Access Predominant role of Tax sumoylation in  

E-Print Network (OSTI)

MEETING ABSTRACT Open Access Predominant role of Tax sumoylation in Tax-induced NF-kB activation of the NF-kB pathway, a property that is required for HTLV-1-induced T cell immortalization. Tax activates the NF-kB pathway by acting both at cytoplasmic and nuclear levels. In the cytoplasm, Tax binds

Paris-Sud XI, Université de

182

Molecular Cell The Structure of the CYLD USP Domain  

E-Print Network (OSTI)

The tumor suppressor CYLD antagonizes NF-kB and JNK signaling by disassembly of Lys63-linked ubiqui- tin al., 2000). CYLD negatively regulates activation of the cell-survival effec- tor NF-kB, a finding for stimulation of NF-kB and JNK in the innate and adaptive immune response (Jin et al., 2007; Zhang et al., 2006

Komander, David

183

The intersection of NFkappaB and fibroblast growth factor receptor signaling pathways  

E-Print Network (OSTI)

Bio-Rad). Quantification of NF-kB binding to the probe wasBio- Rad). The average NF-kB binding from three independentBio-Rad). Quantification of NF-kB binding to the probe was

Drafahl, Kristine A.

2009-01-01T23:59:59.000Z

184

Blood proteolytic activity elevation and plasma protein degradation in spontaneously hypertensive rat models  

E-Print Network (OSTI)

G-protein alpha s, H-Ras, NF-kB, pard6, PI3K cat class IA,G-protein alpha-s, H-Ras, NF-kB, Pi3k cat class IA, PKA-cat,Beta-catenin, MDM2, MMP-2, NF-kb, PIAS2, SUMO- 1, XPA, p21

Chow, Jason C

2011-01-01T23:59:59.000Z

185

Molecular Cell Recruitment of the Linear Ubiquitin Chain Assembly  

E-Print Network (OSTI)

, and is required for efficient TNF-induced activation of NF-kB and JNK, resulting in apoptosis inhibition. Finally-activated protein (MAP) kinase cascades and NF-kB activation (Wajant et al., 2003). Ligand-induced trimerization., 2008). TRAF2 and RIP1 play important roles in the activation of JNK and NF-kB, respectively (Devin et

Komander, David

186

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing  

E-Print Network (OSTI)

-linked (also known as linear) Ub chains that regulate nuclear factor kB (NF-kB) signaling. Deubi by reducing kcat 240-fold. OTULIN overexpression or knockdown affects NF-kB re- sponses to LUBAC, TNFa has roles in NF-kB activation (Haas et al., 2009; Toku- naga and Iwai, 2012; Tokunaga et al., 2009

Komander, David

187

Metabolic disorders in heart diseases with an inflammatory background  

E-Print Network (OSTI)

2010 This editorial refers to `The p65 subunit of NF-kB binds to PGC-1a, linking inflammation. Introduction Cardiac hypertrophy and heart failure are associated with nuclear factor-kB (NF-kB) activation major pathways. 2. Link between NFkB and PGC-1a pathways The general term NF-kB traditionally refers

Paris-Sud XI, Université de

188

Gene Regulation in M Cell Lineages: In Vitro and In Vivo  

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LTbR agonist (Fig 2-1C). The NF-kB gene relB (Relb) has alsoof relB is regulated by NF-kB activation, and the LT?R andreceptors all signal through NF-kB activation, this finding

Wang, Jing

2011-01-01T23:59:59.000Z

189

Specific Recognition of Linear Ubiquitin Chains by NEMO  

E-Print Network (OSTI)

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-kB Activation Simin.03.007 SUMMARY Activation of nuclear factor-kB (NF-kB), a key medi- ator of inducible transcription in immunity, requires binding of NF-kB essential modulator (NEMO) to ubiquitinated substrates. Here, we report

Komander, David

190

Cancer Cell A Transcriptional Signature and Common  

E-Print Network (OSTI)

. As in atherosclerosis, oxidized LDL and its receptor OLR1 activate the inflammatory pathway through NF-kB, leading, 2006; De Marzo et al., 2007; Naugler and Karin, 2008; Pierce et al., 2009). Constitutively active NF-kB, and mouse models provide evidence for a causative role of NF-kB in malignant conversion and progression

Bulyk, Martha L.

191

Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune  

E-Print Network (OSTI)

. pneumophila lacking the Dot/Icm system is recognized by Toll-like receptors (TLRs), leading to a canonical NF-kB, thereby preventing synthesis of IkB, an inhibitor of the NF-kB transcription factor. Thus, macrophages infected with wildtype L. pneumophila exhibited prolonged activation of NF-kB, which was associated

Vance,. Russell

192

Cloning and characterization of Dorsal homologues in the hemipteran Rhodnius prolixusimb_909 681..690  

E-Print Network (OSTI)

by transcription factors of the Rel/ Nuclear Factor kappa B (Rel/NF-kB) family. We have cloned and characterized is that of Nuclear Factor kappa B (NF-kB), named after the transcrip- tional activator of the immunoglobulin kappa light chain in human B-lymphocytes (Sen & Baltimore, 1986). A func- tional NF-kB transcription factor

Lowenberger, Carl

193

Received 9 Nov 2012 | Accepted 28 Jan 2013 | Published 5 Mar 2013 Regulation of A20 and other OTU  

E-Print Network (OSTI)

such as activation of protein kinase cascades during NF-kB (nuclear factor-kB) activation2,3. Ub modifications described to regulate the transcription factor NF-kB (ref. 6), activation of which depends on an intricate in hyperinflammatory phenotypes consistent with deregulated NF-kB signalling. Mechanistically, A20 establishes

Komander, David

194

Molecular Cell Noncooperative Interactions between Transcription  

E-Print Network (OSTI)

the definition of anatomical boundaries during development. Here we show that NF-kB, a TF controlling noncoop- eratively. We observed that increasing concentra- tions of NF-kB are translated into gradual by combining quantitative measurements and a minimal physical model of an NF-kB-dependent promoter. We

Bulyk, Martha L.

195

Functional dissection of homeodomain transcription factors HoxA9 and Meis1 in myeloid leukemia : their epigenetic regulation and their downstream targets  

E-Print Network (OSTI)

protein 3. A20. Neg reg Toll/NF-kB signaling Socs3 Cytokine-2, C polypeptide. Adhesion, NF-kB activation Hsd11b1Peli1 Pellino1. Required for NF-kB activation through IL1R

Wang, Gang

2006-01-01T23:59:59.000Z

196

Second SICSA Workshop on Biological Networks: Theory and Applications  

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stimulation, oscillatory MAPK, p53, NF-kB network with optional UV modulation Oscillations have been factor kappa-light-chain-enhancer of activated B cell (NF-kB) is conducted. A candidate for a tumor necrosis factor- (TNF-) controlled stimulation, oscillating MAPK, p53, NF-kB network with optional

Edinburgh, University of

197

ARTICLE doi:10.1038/nature09853 Crystal structure of inhibitorof kB kinase b  

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a similar trimodular architecture and function. Nuclear factor kB (NF-kB) transcription factors are master regulators of inflammatory, immune and apoptotic responses1,2 . In the canonical pathway, NF-kB dimers. When cells are stimulated by NF-kB inducers, IkB proteins are phosphorylated by the Ser

Wu, Hao

198

Table HC1-12a. Housing Unit Characteristics by West Census Region,  

U.S. Energy Information Administration (EIA) Indexed Site

2a. Housing Unit Characteristics by West Census Region, 2a. Housing Unit Characteristics by West Census Region, Million U.S. Households, 2001 Housing Unit Characteristics RSE Column Factor: Total U.S. West Census Region RSE Row Factors Total Census Division Mountain Pacific 0.5 1.0 1.7 1.1 Total .............................................................. 107.0 23.3 6.7 16.6 NE Census Region and Division Northeast ..................................................... 20.3 -- -- -- NF New England ............................................. 5.4 -- -- -- NF Middle Atlantic ........................................... 14.8 -- -- -- NF Midwest ....................................................... 24.5 -- -- -- NF East North Central ..................................... 17.1 -- -- -- NF West North Central ....................................

199

Decay constants of B and D mesons from improved relativistic lattice QCD with two flavours of sea quarks  

E-Print Network (OSTI)

We present a calculation of the B and D meson decay constants in lattice QCD with two (Nf=2) flavours of light dynamical quarks, using an O(a)-improved Wilson action for both light and heavy quarks and a renormalization-group improved gauge action. Simulations are made at three values of lattice spacing a=0.22, 0.16, 0.11 fm and four values of sea quark mass in the range m_PS/m_V \\~= 0.8-0.6. Our estimate for the continuum values of the decay constants are fBd = 208(10)(11) MeV, fBs = 250(10)(13)(^{+8}_{-0}) MeV, fDd = 225(14)(14) MeV, fDs = 267(13)(17)(^{+10}_{-0}) MeV for Nf=2 where the statistical and systematic errors are separately listed, and the third error for fBs and fDs show uncertainty of determination of strange quark mass. We also carry out a set of quenched simulations using the same action to make a direct examination of sea quark effects. Taking the ratio of results for Nf=2 and Nf=0, we obtain fb^{Nf=2}/fb^{Nf=0} = 1.11(6), fbs^{Nf=2}/fbs^{Nf=0} = 1.14(5), fd^{Nf=2}/\\fd^{Nf=0} = 1.03(6), fds^...

Khan, A A; Burkhalter, R; Ejiri, S; Fukugita, M; Hashimoto, S; Ishizuka, N; Iwasaki, Y; Kanaya, K; Kaneko, T; Kuramashi, Y; Manke, T; Nagai, K; Okawa, M; Shanahan, H P; Ukawa, A; Yoshi, T

2001-01-01T23:59:59.000Z

200

6. Chan, F. K., Siegel, M. R. & Lenardo, J. M. Signaling by the TNF receptor superfamily and T cell homeostasis. Immunity 13, 419422 (2000).  

E-Print Network (OSTI)

, T., Green, D. R. & Verma, I. M. Suppression of TNF-a-induced apoptosis by NF-kB. Science 274, 787 functions: JNK activation is not linked to apoptosis while NF-kB activation prevents cell death. Cell 87., Dixit, V. M. & Goeddel, D. V. TRAF2-mediated activation of NF-kB by TNF receptor 2 and CD40. Science 269

Hutchinson, John

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
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We encourage you to perform a real-time search of NLEBeta
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201

of May 16, 2013. This information is current as  

E-Print Network (OSTI)

-binding proteins TGF-b­activated kinase 1 (TAK1)­binding protein (TAB)2 and TAB3 are implicated in NF-kB signaling via TAK1 activation. However, TAB2 alone is dispensable for NF-kB activation in embryonic fibroblasts, but not NF-kB, in response to TLR and CD40 stimulation in B cells. Surprisingly, TAB2 and TAB3

202

RELB, A NEW PARTNER OF ARYL HYDROCARBON RECEPTOR-MEDIATED TRANSCRIPTION  

E-Print Network (OSTI)

-00268250,version1-31Mar2008 #12;3 INTRODUCTION The NF-kB/Rel transcription factors play critical roles, and apoptosis. Transcriptionally active NF-kB dimers are formed by combinatorial association of five subunits: p50, RelA (p65), p52, c-Rel, and RelB (1). The classic inducible NF-kB heterodimer consists of the p50

Paris-Sud XI, Université de

203

A jB sequence code for pathway-specific innate immune responses  

E-Print Network (OSTI)

of the NF-kB family of transcription factors, for example, vertebrate p50 and p65 (Ghosh et al, 1998; Karin and Ben-Neriah, 2000; Brennan and Anderson, 2004; Xiao and Ghosh, 2005). In the absence of a stimulus, NF-kB that allow NF-kB factors to enter the nucleus and direct expression of antimicrobial agents and secondary

204

(161), ra11. [DOI: 10.1126/scisignal.2001501]4Science Signaling Benedict, Gourisankar Ghosh and Alexander Hoffmann (22 February 2011)  

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of Interferon Response Elements by NF-kB p50 Christine S. Cheng,1,2,3 Kristyn E. Feldman,1,2 James Lee,1 programs. Members of the nuclear factor kB (NF-kB) and interferon (IFN) regulatory factor (IRF-down and bottom-up systems biology approaches, we have identified the NF-kB p50 homodimer as a regulator of IRF

Hasty, Jeff

205

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3  

E-Print Network (OSTI)

function and NF-kB signaling Di Sha, Lih-Shen Chin? and Lian Li? Department of Pharmacology and CenterB kinase/nuclear factor kB (NF-kB) pathway. Furthermore, the ability of PINK1 to promote parkin-mediated ubiquitin signaling and implicate the deregulation of the PINK1/parkin/NF-kB neuroprotective signaling

Li, Lian

206

www.cell-research.com | Cell Research Guoliang Qing et al.  

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B, inhibitor of NF-kB; IKK, IkB kinase Received 28 September 2006; revised 9 October 2006; accepted 10 October that the IkB kinase (IKK), an essential activator of NF-kB, is selectively degraded by autophagy when Hsp90 and establish a molecular link among Hsp90, NF-kB and autophagy Cell Research (2006) 16:895-901. doi:10.1038/sj

Cai, Long

207

letters to nature NATURE |VOL 414 |13 DECEMBER 2001 |www.nature.com 759  

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±1318 (1999). 2. Khush, R. S., Leulier, F. & Lemaitre, B. Drosophila immunity: two paths to NF-kB. Trends. Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kB receptor-mediated Drosophila immune response requires Dif, an NF-kB factor. Genes Dev. 13, 792±797 (1999

Schnaufer, Achim

208

Molecular Cell Hydrogen Sulfide-Linked Sulfhydration  

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Molecular Cell Article Hydrogen Sulfide-Linked Sulfhydration of NF-kB Mediates Its Antiapoptotic@jhmi.edu DOI 10.1016/j.molcel.2011.10.021 SUMMARY Nuclear factor kB (NF-kB) is an antiapoptotic tran- scription factor. We show that the antiapoptotic actions of NF-kB are mediated by hydrogen sulfide (H2S

Dong, Xinzhong

209

POSTER PRESENTATION Open Access HIV triggers immunoregulatory dendritic cells  

E-Print Network (OSTI)

T cells through the non-canonical NF-kB pathway O Manches1* , MV Fernandez1 , J Plumas2 , L Chaperot2 , N activation of the non-canonical NF-kB pathway in pDC, and is essential for IDO induction. TLR7 triggering-dependent fashion, allowing cDC to induce Treg from naïve CD4+ T cells. Conclusion The non-canonical NF-kB pathway

Paris-Sud XI, Université de

210

Epigenetic Upregulation of lncRNAs at 13q14.3 in Leukemia Is Linked to the In Cis Downregulation of a  

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of a Gene Cluster That Targets NF-kB Angela Garding1,2. , Nupur Bhattacharya1.¤a , Rainer Claus3¤b , Melanie NF-kB activity, which we could show after overexpression, siRNA­mediated knockdown, and dominant/16 family of genes at 13q14.3 as the strongest inducers of NF-kB activity. In summary, the tumor suppressor

Rippe, Karsten

211

Molecular Cell Structural Basis for Recognition  

E-Print Network (OSTI)

.01.012 SUMMARY NEMO is the regulatory subunit of the IkB kinase (IKK) in NF-kB activation, and its CC2-LZ region. INTRODUCTION NF-kB proteins are evolutionarily conserved master regulators of immune and inflammatory responses/Thr-specific IkB kinase (IKK) signalosome is at the bottleneck for NF-kB activation because activated IKK

Wu, Hao

212

(290), ra75. [DOI: 10.1126/scisignal.2004097]6Science Signaling Linda C. Hsieh-Wilson and David Baltimore (27 August 2013)  

E-Print Network (OSTI)

Function of the NF-kB Protein c-Rel by O-GlcNAc Glycosylation Parameswaran Ramakrishnan,1 * Peter M. Clark factor nuclear factor kB (NF-kB) rapidly reprograms gene expression in response to various stimuli stress. We report that the NF-kB subunit c-Rel is modified and acti- vated by O-GlcNAcylation. We

Gleeson, Joseph G.

213

Lattice Study of the Conformal Window in QCD-like Theories  

E-Print Network (OSTI)

Using lattice simulations, we study the extent of the conformal window for an $\\text{SU}(3)$ gauge theory with $N_f$ Dirac fermions in the fundamental representation. We present evidence that the infrared behavior is conformal for $12 \\leq N_f \\leq 16$, governed by an infrared fixed point, while confinement and chiral symmetry breaking are present for $N_f \\leq 8$.

Thomas Appelquist; George T. Fleming; Ethan T. Neil

2007-12-04T23:59:59.000Z

214

Table HC1-11a. Housing Unit Characteristics by South Census Region,  

U.S. Energy Information Administration (EIA) Indexed Site

1a. Housing Unit Characteristics by South Census Region, 1a. Housing Unit Characteristics by South Census Region, Million U.S. Households, 2001 Housing Unit Characteristics RSE Column Factor: Total U.S. South Census Region RSE Row Factors Total Census Division South Atlantic East South Central West South Central 0.5 0.9 1.2 1.4 1.4 Total .............................................................. 107.0 38.9 20.3 6.8 11.8 NE Census Region and Division Northeast ..................................................... 20.3 -- -- -- -- NF New England ............................................. 5.4 -- -- -- -- NF Middle Atlantic ........................................... 14.8 -- -- -- -- NF Midwest ....................................................... 24.5 -- -- -- -- NF East North Central .....................................

215

Single-qubit-gate error below 10 in a trapped ion  

Science Conference Proceedings (OSTI)

... computers depends on the ability to accurately control sensitive super- position amplitudes by ... near 1.25 GHz, coupled with a 4-nF capacitor to one ...

2011-10-28T23:59:59.000Z

216

THE LONG TERM CALIBRATION STABILITY OF CRITICAL ...  

Science Conference Proceedings (OSTI)

... through nf flow tubes with circular cross section, ... Real Gas Eflects in Critical Flow through Nozzles ... of the Effects of Heat Transfer and Compressible ...

2012-10-29T23:59:59.000Z

217

Mosaic neurofibromatosis type 1  

E-Print Network (OSTI)

with neurofibromatosis type 1 (NF1) with microdeletionsM, Huson S. Mosaic (segmental) neurofibromatosis type 1and type 2: no longer neurofibromatosis type 5. Am J Med

Liang, Christine; Schaffer, Julie V

2008-01-01T23:59:59.000Z

218

Construction of Risk-Averse Enhanced Index Funds  

E-Print Network (OSTI)

?George Washington University, Washington, DC, 20052, mlejeune@gwu.edu. The author is partially supported by the Grant #. W911NF-09-1-0497 from the...

219

NVN-079666 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2541.85 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

220

NVN-079352 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1160 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

NVN-079665 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2560 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

222

NVN-079668 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2585.51 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

223

NVN-079664 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

224

NVN-074253 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

225

NVN-079307 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

226

NVN-079663 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2213.1 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

227

NVN-079310 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 655 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

228

NVN-074250 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1199 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

229

NVN-074254 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

230

Table 2. Fuel Oil Consumption and Expenditures in U.S. Households ...  

U.S. Energy Information Administration (EIA)

1 A small amount of fuel oil used for appliances is included in "Fuel Oil" under "All Uses." NF = No applicable RSE row factor.

231

BMC Cancer BioMed Central  

E-Print Network (OSTI)

Research article Genistein inhibits radiation-induced activation of NF-?B in prostate cancer cells promoting apoptosis and G2 /M cell cycle arrest

Julian J Raffoul; Yu Wang; Omer Kucuk; Jeffrey D Forman; Fazlul H Sarkar; Gilda G Hillman; Jeffrey D Forman; Fazlul H Sarkar; Gilda G Hillman

2006-01-01T23:59:59.000Z

232

Stuart R Hudson | Princeton Plasma Physics Lab  

NLE Websites -- All DOE Office Websites (Extended Search)

approach for optimizing currents in H-1NF stellarator in operation in the Plasma Research Laboratory at the ANU to control vacuum magnetic islands was introduced. After...

233

Slide 1  

National Nuclear Security Administration (NNSA)

chemistry (AC) and materials characterization (MC) mission work CMR Chemistry and Metallurgy Research CMRR-NF CMR Replacement - Nuclear Facility RLUOB Radiological...

234

Chemistry and Metallurgy Research Replacement - Nuclear Facility...  

National Nuclear Security Administration (NNSA)

Chemistry and Metallurgy Research Replacement - Nuclear Facility (CMRR-NF SEIS) | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing...

235

CACA-014408 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 693.6 Bid PriceAcre Managing Field Office none provided Surface Manager INYO NF Lessee 1...

236

NVN-077646 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 80 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

237

NVN-079667 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1920 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

238

NVN-077647 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 640 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

239

NVN-079276 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 640 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

240

NVN-078687 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLEASENONCOMPETITI Total Acreage 1180 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 REESE...

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

NVN-079291 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1295.88 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

242

NVN-077668 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLEASENONCOMPETITI Total Acreage 3297.94 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 NGP BLUE...

243

CACA-011667 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 1590 Bid PriceAcre Managing Field Office none provided Surface Manager INYO NF Lessee 1...

244

NVN-080159 | Open Energy Information  

Open Energy Info (EERE)

(section) Case Status Authorized Case Type GEOLEASENONCOMPETITI Total Acreage 640 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 NGP BLUE...

245

Die Jontophorese der mit medikamentö  

Science Conference Proceedings (OSTI)

Flora, 131. N.F. 31, 87--112, 1936. Die bevorzugte Aufnahme saurer Farbstoffe bei hoher Wasserstoffionen- konzentration der die Zellen yon Asperffillus niger...

246

Dynamic Modeling of Behavior Change H. T. Banks, Keri L. Rehm, Karyn L. Sutton  

E-Print Network (OSTI)

chacun des noeuds des deux documents : sds1(r) = snf 1(r) = pr tree ? p nf 1 tree + pr paper ? pnf 1

247

Control of size and charge selectivity in amphiphilic graft copolymer nanofiltration membranes  

E-Print Network (OSTI)

The throughput and efficiency of membrane separations make polymer filtration membranes an important resource for the pharmaceutical, food and wastewater treatment industries. Nanofiltration (NF) membranes fill an important ...

Lovell, Nathan Gary

2010-01-01T23:59:59.000Z

248

Numerical Investigation of Interaction Between Hydraulic Fractures and Natural Fractures  

E-Print Network (OSTI)

Hydraulic fracturing of a naturally-fractured reservoir is a challenge for industry, as fractures can have complex growth patterns when propagating in systems of natural fractures in the reservoir. Fracture propagation near a natural fracture (NF) considering interaction between a hydraulic fracture (HF) and a pre-existing NF, has been investigated comprehensively using a two dimensional Displacement Discontinuity Method (DDM) Model in this thesis. The rock is first considered as an elastic impermeable medium (with no leakoff), and then the effects of pore pressure change as a result of leakoff of fracturing fluid are considered. A uniform pressure fluid model and a Newtonian fluid flow model are used to calculate the fluid flow, fluid pressure and width distribution along the fracture. Joint elements are implemented to describe different NF contact modes (stick, slip, and open mode). The structural criterion is used for predicting the direction and mode of fracture propagation. The numerical model was used to first examine the mechanical response of the NF to predict potential reactivation of the NF and the resultant probable location for fracture re-initiation. Results demonstrate that: 1) Before the HF reaches a NF, the possibility of fracture re-initiation across the NF and with an offset is enhanced when the NF has weaker interfaces; 2) During the stage of fluid infiltration along the NF, a maximum tensile stress peak can be generated at the end of the opening zone along the NF ahead of the fluid front; 3) Poroelastic effects, arising from fluid diffusion into the rock deformation can induce closure and compressive stress at the center of the NF ahead of the HF tip before HF arrival. Upon coalescence when fluid flows along the NF, the poroelastic effects tend to reduce the value of the HF aperture and this decreases the tension peak and the possibility of fracture re-initiation with time. Next, HF trajectories near a NF were examined prior to coalesce with the NF using different joint, rock and fluid properties. Our analysis shows that: 1) Hydraulic fracture trajectories near a NF may bend and deviate from the direction of the maximum horizontal stress when using a joint model that includes initial joint deformation; 2) Hydraulic fractures propagating with higher injection rate or fracturing fluid of higher viscosity propagate longer distance when turning to the direction of maximum horizontal stress; 3) Fracture trajectories are less dependent on injection rate or fluid viscosity when using a joint model that includes initial joint deformation; whereas, they are more dominated by injection rate and fluid viscosity when using a joint model that excludes initial joint deformation.

Xue, Wenxu

2010-12-01T23:59:59.000Z

249

ROCKY MOUNTAIN JOURNAL OF MATHEMATICS  

E-Print Network (OSTI)

factors of i = 1,...,t, j = 1,...,n-1, by n, we have nfAjm+i = (jmnf +nif -nf +n).-.(jmnf +nif) = (.(if - f +1) -j)...(nif - j) (modp), so that Multiplying both sides of this congruence by Bn = n(2n) .(tf n

Williams, Kenneth Stuart

250

LINE","COMPNAME","COMPID","YEAR","PURCNAME","SALETYPE","MEGAWATT...  

U.S. Energy Information Administration (EIA) Indexed Site

Spencer City of",554,1999,"Iowa State University","NF",3543,0,0,87758,87758 2,"Spencer City of",554,1999,"Alliant","NF",28,0,0,1443,1443 3,"Spencer City of",554,1999,"Mid-America...

251

Cytokine-Induced Signaling Networks Prioritize Dynamic Range  

E-Print Network (OSTI)

. For example, the transcription factor nuclear factor-kB (NF-kB) is widely regarded as a prosurvival protein-IAP2, Bcl-xL, and c-FLIP (Karin and Lin, 2002). In response to DNA-damaging agents, however, nuclear NF-kB

252

Noise-Limited Frequency Signal Transmission in Gene Circuits Cheemeng Tan,* Faisal Reza,*y  

E-Print Network (OSTI)

clocks (2), Ca21 signaling pathways (3,4), p53 DNA repair pathways (5), NF-kB pathways (6), and cell of ;0.008/s significantly increased the activity of Ras proteins (22). Similarly, the frequency of NF-kB

You, Lingchong

253

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer  

E-Print Network (OSTI)

(Watanabe et al., 2008). NOD2 stimulation leads to the activation of MAP kinase and NF-kB signaling pathways). Together, these studies suggest that innate immune signaling triggered by the commensal bacteria-TLR or NOD-NF-kB

254

Molecular Cell Short Article  

E-Print Network (OSTI)

of an HBO1 complex, ING4 has also been reported to repress transcription of the NF-kB and hypoxia response to directly interact with the RelA subunit of NF-kB and with Egln1/HPH2 (hypoxia inducible factor Prolyl

Gozani, Or

255

Molecular Cell Control of Proinflammatory Gene  

E-Print Network (OSTI)

-depen- dent erasure of H4K20me3 is required for effective gene activation and is achieved by NF-kB-depen- dent such as nuclear factor-k B (NF-kB), activator protein 1 (AP1), and interferon regulatory factor (IRFs

Higgins, Darren

256

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis  

E-Print Network (OSTI)

of signal 1 (NF-kB), the NLRP3 inflammasome was activated by mitochon- drial apoptotic signaling activation (Latz, 2010). The first signal (signal 1), often NF-kB activation, induces pro-IL-1b and NLRP3

257

Identification of genetic variation and putative regulatory regions in bovine CARD15  

E-Print Network (OSTI)

have an enhanced ability to activate nuclear factor kappa-B (NF-kB) (Miceli-Richard et al. 2001), while components resulting in a perturbation of NF-kB activation (Girardin et al. 2003; Gutierrez et al. 2002

Taylor, Jerry

258

Tumor and Stem Cell Biology Akt2 Regulates All Akt Isoforms and Promotes Resistance to  

E-Print Network (OSTI)

of NF-kB, cAMP responsive element­binding protein (CREB), and CBP/p300 to the miR-21 promoter (6). The LKB1/AMPK pathway on the other hand, inhibits mTOR and activates NF-kB and Notch1

259

NIKKI GEORGINA TRAYLOR-KNOWLES ntk1717@gmail.com (410) 905-5107  

E-Print Network (OSTI)

., Goucher, H., Finnerty, J.R., Gilmore, T.D. (2010) Characterization of the core elements of the NF-kB., Gilmore, T.D., and Finnerty, J.R. (2009) Two alleles encoding transcription factor NF-kB in the sea

Palumbi, Stephen

260

Worksheet  

U.S. Energy Information Administration (EIA) Indexed Site

ty",6,3,"AVISTA","NF",573733,,,22608999,22608999 3413,"PUD No 1 of Chelan County",6,4,"BC HYDRO","NF",5,,,211,211 3413,"PUD No 1 of Chelan County",6,5,"BENTON COUNTY...

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Table HC1-9a. Housing Unit Characteristics by Northeast Census Region,  

U.S. Energy Information Administration (EIA) Indexed Site

9a. Housing Unit Characteristics by Northeast Census Region, 9a. Housing Unit Characteristics by Northeast Census Region, Million U.S. Households, 2001 Housing Unit Characteristics RSE Column Factor: Total U.S. Northeast Census Region RSE Row Factors Total Census Division Middle Atlantic New England 0.5 1.0 1.2 1.6 Total .............................................................. 107.0 20.3 14.8 5.4 NE Census Region and Division Northeast ..................................................... 20.3 20.3 14.8 5.4 NF New England ............................................. 5.4 5.4 Q 5.4 NF Middle Atlantic ........................................... 14.8 14.8 14.8 Q NF Midwest ....................................................... 24.5 -- -- -- NF East North Central ..................................... 17.1 -- -- -- NF

262

Property:SurfaceManager | Open Energy Information  

Open Energy Info (EERE)

SurfaceManager SurfaceManager Jump to: navigation, search Property Name SurfaceManager Property Type Page Pages using the property "SurfaceManager" Showing 25 pages using this property. (previous 25) (next 25) A AZA-009168 + COCONINO NF + AZA-009169 + COCONINO NF + AZA-009170 + COCONINO NF + AZA-009171 + FOREST SERVICE + AZA-009172 + FOREST SERVICE + AZA-009173 + FOREST SERVICE + AZA-009174 + FOREST SERVICE + AZA-009175 + COCONINO NF + AZA-009176 + BUREAU OF LAND MGMT + AZA-009177 + FOREST SERVICE + AZA-009178 + FOREST SERVICE + AZA-009179 + FOREST SERVICE + AZA-009180 + FOREST SERVICE + AZA-009181 + FOREST SERVICE + AZA-009182 + FOREST SERVICE + AZA-009183 + FOREST SERVICE + AZA-009184 + FOREST SERVICE + AZA-009185 + FOREST SERVICE + AZA-009186 + COCONINO NF +

263

Study of Possible Ultraviolet Zero of the Beta Function in Gauge Theories with Many Fermions  

E-Print Network (OSTI)

We study the possibility of an ultraviolet (UV) zero in the $n$-loop beta function of U(1) and non-Abelian gauge theories with $N_f$ fermions for large $N_f$. The effect of scheme transformations on the coefficients of different powers of $N_f$ in the $n$-loop term in the beta function is calculated. A general scheme-independent criterion is given for determining whether or not the $n$-loop beta function has a UV zero for large $N_f$. We compare the results with exact integral representations of the leading terms in the beta functions for the respective Abelian and non-Abelian theories in the limit $N_f \\to \\infty$ limit with $N_f \\alpha$ finite. As part of this study, new analytic and numerical results are presented for certain coefficients, denoted $b_{n,n-1}$, that control the large-$N_f$ behavior at $n$-loop order in the beta function. We also investigate various test functions incorporating a power-law and essential UV zero in the beta function and determine their manifestations in series expansions in powers of coupling and in powers of $1/N_f$.

Robert Shrock

2013-11-20T23:59:59.000Z

264

Somatic mosaicism in a patient with neurofibromomatosis type 1  

SciTech Connect

Using loss of heterozygosity analysis, a method designed to detect moderate to large gene deletions, we have identified a new-mutation neurofibromatosis type 1 (NF1) patient who is somatically mosaic for a large maternally derived deletion in the NF1 gene region. The deletion extends at least from exon 4 near the 5{prime} end of the gene to intron 39 near the 3{prime} end. The gene-coding region is, therefore, mostly or entirely deleted, encompassing a loss of {>=}100 kb. We hypothesize that the deletion occurred at a relatively early developmental timepoint, since signs of NF in this patient are not confined to a specific body region, as seen in {open_quotes}segmental{close_quotes} NF, and since both mesodermally and ectodermally derived cells are affected. This report provides the first molecular evidence of somatic mosaicism in NF1 and, taken together with a recent report of germ-line mosaicism in NF1, adds credence to the concept that mosaicism plays an important role in phenotypic and genetic aspects of NF1 and may even be a relatively common phenomenon. 37 refs., 4 figs.

Colman, S.D.; Rasmussen, S.A.; Ho, V.T. [Univ. of Florida, Gainesville, FL (United States)] [and others

1996-03-01T23:59:59.000Z

265

Immunoglobulin motif DNA recognition and  

E-Print Network (OSTI)

binding domains of NF-kB, NFAT1, p53 and the STAT proteins. NMR spectroscopy of a 43.6 kD RD­b­DNA ternary for NF-kB3-4, the nuclear factor of acti- vated T-cells NFAT1 (refs 5,6), STAT1 (ref. 7) and STAT3b8 72 and Ser 73. In con- trast, the N-terminus of NF-kB3-4 and NFAT1 (refs 5, 6) loops around

Sali, Andrej

266

Identificado un nuevo indicador de recada en el cncer de mama http://www.lavanguardia.com/salud/20120619/54313501609/identificado-nuevo-indicador-recaida-cancer-mama.html[19/06/2012 12:09:50  

E-Print Network (OSTI)

células para activar la señalización de un complejo proteico llamado NF-kB que está relacionado con la activación de NF-kB en los tumores, como el mejor indicador de recaída en las pacientes de cáncer de mama, en requerimiento esencial para que se mantenga activado de manera crónica el complejo NF-kB, asociado a la invasión

Foissac, Sylvain

267

Nepali Aawaz Volume 1, Issue 2, 13-18 October 2005  

E-Print Network (OSTI)

/f]xdf g]kfnsf Vofltk|fKt nf]sufos >L k|]d/fhf dxtsf] lxdfnog Do"lhs ;d"xn] df}sf kfPsf] 5 . hfgsf/L cg';f/ g]zgn sfplG;n km/ b 6]l8;gn cf6{;\\ n] jfl;6g l8=;L= l: yt g]kfnL /fhb"tfjf;nfO{ Ps kq n]vL nf]s ufos >L k|]d/fhf dxt / pgsf] ;fF:s[lts 6...

Shrestha, Kashish Das

268

Parity Doubling and the S Parameter Below the Conformal Window  

E-Print Network (OSTI)

We describe a lattice simulation of the masses and decay constants of the lowest-lying vector and axial resonances, and the electroweak S parameter, in an SU(3) gauge theory with $N_f = 2$ and 6 fermions in the fundamental representation. The spectrum becomes more parity doubled and the S parameter per electroweak doublet decreases when $N_f$ is increased from 2 to 6, motivating study of these trends as $N_f$ is increased further, toward the critical value for transition from confinement to infrared conformality.

Thomas Appelquist; Ron Babich; Richard C. Brower; Michael Cheng; Michael A. Clark; Saul D. Cohen; George T. Fleming; Joe Kiskis; Meifeng Lin; Ethan T. Neil; James C. Osborn; Claudio Rebbi; David Schaich; Pavlos Vranas

2010-09-29T23:59:59.000Z

269

Table HC1-10a. Housing Unit Characteristics by Midwest Census Region,  

U.S. Energy Information Administration (EIA) Indexed Site

0a. Housing Unit Characteristics by Midwest Census Region, 0a. Housing Unit Characteristics by Midwest Census Region, Million U.S. Households, 2001 Housing Unit Characteristics RSE Column Factor: Total U.S. Midwest Census Region RSE Row Factors Total Census Division East North Central West North Central 0.5 1.0 1.2 1.8 Total .............................................................. 107.0 24.5 17.1 7.4 NE Census Region and Division Northeast ..................................................... 20.3 -- -- -- NF New England ............................................. 5.4 -- -- -- NF Middle Atlantic ........................................... 14.8 -- -- -- NF Midwest ....................................................... 24.5 24.5 17.1 7.4 NF East North Central ..................................... 17.1 17.1

270

Microsoft Word - Chapter 04.doc  

National Nuclear Security Administration (NNSA)

poorly welded tuff layer. This would reduce the number of trucks transporting concrete mix from the batch plant to the Modified CMRR-NF. While the total number of trucks would be...

271

CACA-014407 | Open Energy Information  

Open Energy Info (EERE)

Bid PriceAcre Managing Field Office none provided Surface Manager INYO NF Lessee 1 ORNI 51 LLC Lessee 2 none provided Effective Date 211985 Expire Date Held By Production (HBP)...

272

outbind://6-000000007B09B0C78182DD468D210820B7D48C0A070041ECF0B  

National Nuclear Security Administration (NNSA)

11172010 Dear Mr. John Tegtmeir, I have attached comments from Tewa Women United for the CMRR-NF. I do hope they are taken seriously and worthy of some more dialogues into the...

273

Primal-dual subgradient method for Huge-Scale Linear Conic ...  

E-Print Network (OSTI)

For N ? 0, denote by FN the set of iterations of type (F), which were used for generating the point yN+1. And let GN def. = {0,...,N}\\FN , Nf def. = |FN |, and Ng def.

274

On the Globally Concavized Filled Function Method ?  

E-Print Network (OSTI)

The test results of the above 8 problems are presented in Table 1. Table 1. Numerical results of the algorithm. Problem No. n. NF. NG. NFF. NFG. LNF. LNG.

275

2008ENGINEERING SCHOLARS PROGRAM 2008 JOURNAL  

E-Print Network (OSTI)

St. Marie Madeleine Parish By Akua Abu, Andrew Acevedo, Ari Bogotch, Jared Carron, Adam Carter, including the 470 nF capacitor and25. 1 M resistor at the buffer amplifier input. The capacitor is used

Marques, Oge

276

Design and synthesis of probes for detection of protein-protein interaction and RNA localization  

E-Print Network (OSTI)

The use of the ketone biotin - benzophenone-biotin hydrazide system for detecting the formation of cyan fluorescent protein and NF-kappaB p50 dimers was assessed. A series of benzophenone-based probes were synthesized and ...

Ryan, Jeremy Adam

2005-01-01T23:59:59.000Z

277

Nitrogen trifluoride global emissions estimated from updated atmospheric measurements  

E-Print Network (OSTI)

Nitrogen trifluoride (NF[subscript 3]) has potential to make a growing contribution to the Earths radiative budget; however, our understanding of its atmospheric burden and emission rates has been limited. Based on a ...

Ivy, Diane J.

278

Robust Efficient Frontier Analysis with a Separable Uncertainty Model  

E-Print Network (OSTI)

Institute on Energy Efficiency, by Army award W911NF-07-1-0029, by NSF award ECS-. 0423905, by NSF award .... [29] R. Green and B. Hollifield. When will...

279

Surface Electrode Ion Microtrap Fabrication 729nm ECDL with ...  

Science Conference Proceedings (OSTI)

... vs. 1.3 fF/m2). Capacitors are located within microns of DC electrode. 1nF trench capacitor is about ... ultra-high vacuum GR Brady et al. ...

2011-03-01T23:59:59.000Z

280

Career Options Program/Courses Resources Why Choose Computer Engineering  

E-Print Network (OSTI)

? · Design things that people use. · Computers, personal electronics. · Cars, planes etc. -- much/Courses Resources Employers Utilities NL Hydro, NF Power, Aliant, Ontario Hydro Resource/Heavy Industry Petro

Peters, Dennis

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281

Bioremediation of contaminated groundwater  

DOE Patents (OSTI)

Disclosed is an apparatus and method for in situ remediation of contaminated subsurface soil or groundwater contaminated by chlorinated hydrocarbons. A nutrient fluid (NF) is selected to simulated the growth and reproduction of indigenous subsurface microorganisms capable of degrading the contaminants; an oxygenated fluid (OF) is selected to create an aerobic environment with anaerobic pockets. NF is injected periodically while OF is injected continuously and both are extracted so that both are drawn across the plume. NF stimulates microbial colony growth; withholding it periodically forces the larger, healthy colony of microbes to degrade the contaminants. Treatment is continued until the subsurface concentration of contaminants is acceptable. NF can be methane and OF be air, for stimulating production of methanotrophs to break down chlorohydrocarbons, especially TCE and tetrachloroethylene.

Hazen, T.C.; Fliermans, C.B.

1994-01-01T23:59:59.000Z

282

Process Mineralogy  

Science Conference Proceedings (OSTI)

"The Exhumed 'Carlin-Type' Fossil Oil Reservoir at Yankee Basin" (Overview), J.B. Hulen, J.W. Collister, B. Stout, D.K. Curtiss, and N.F. Dahdah, December...

283

NVN-079104 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2480.99 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 ORNI 16...

284

AZA-009168 | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2005 Bid PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT W H...

285

NVN-079105 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2356.36 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 ORNI 16...

286

AZA-009186 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2471.1 Bid PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT OIL...

287

AZA-009170 | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 1920 Bid PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT W H...

288

NVN-079305 | Open Energy Information  

Open Energy Info (EERE)

1 Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1811.109 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

289

AZA-009175 | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2190 Bid PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT W H...

290

NVN-079106 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2588.75 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 ORNI 16...

291

AZA-009191 | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2560 Bid PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT OIL...

292

AZA-009169 | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2560 Bid PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT W H...

293

NVN-077739 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1271.82 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 PATUA...

294

AZA-009190 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Closed Case Type GEOLSENONCOMPPRE2005 Total Acreage 2018.7 Bid PriceAcre Managing Field Office none provided Surface Manager COCONINO NF Lessee 1 HUNT OIL...

295

Microsoft Word - Appendix C.doc  

National Nuclear Security Administration (NNSA)

fraction values are also taken from the hazard analysis information for the CMR Building and CMRR-NF (LANS 2011a, 2011b), or the DOE Handbook on airborne release...

296

PolynomialIdeals.f4 - CECM - Simon Fraser University  

E-Print Network (OSTI)

... construct a lookup table for monomials (used by nf_proc) mbasis := [seq( mbasis[i],i=1..n)]; basis_lookup := table(zip(`=`,mbasis,[seq(i,i=1..n)])); # initialize XLA...

297

CRYOPUMP BEHAVIOR IN THE PRESENCE OF BEAM OR NUCLEAR RADIATION  

E-Print Network (OSTI)

63, 151 T. Kaimcash. Fusion Reactor Physics (Ann ArborTritium Technology For Fusion Reactors. C0NF-750989 (OakA. Impurity Effects in Fusion Reactor Operations B.

Law, P.K.

2011-01-01T23:59:59.000Z

298

Structure and Biochemistry of IKappaB Zeta : : A Nuclear IKappaB Protein  

E-Print Network (OSTI)

NF-?B Nuclear factor -?B NSLS National Synchrotron LightSynchrotron Light Source (NSLS) in Brookhaven. We used thePDB accession code NSLS#25 P65 Data in parentheses are for

Zhu, Norman L.

299

appl_household2001.pdf  

Annual Energy Outlook 2012 (EIA)

... Q Q Q Q Q NF Other Appliances Automobile BlockEngine Battery Heater ... 0.5 0.3 Q 0.1 Q 37.2 Ceiling Fans...

300

UTU-029557 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 2594.37 Bid PriceAcre Managing Field Office none provided Surface Manager FISHLAKE NF Lessee 1 ENEL...

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

NVN-080086 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLEASENONCOMPETITI Total Acreage 650.32 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 NGP BLUE...

302

CACA-011672 | Open Energy Information  

Open Energy Info (EERE)

(40 Acres) Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 800 Bid PriceAcre Managing Field Office none provided Surface Manager INYO NF Lessee 1 ORNI 10 LLC...

303

NVN-074249 | Open Energy Information  

Open Energy Info (EERE)

Lot Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1860.19 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

304

Review Accurate thermochemistry from quantum chemical ...  

Science Conference Proceedings (OSTI)

Lipkowitz KB (eds) Rev Comp Chem 15:147; b) Curtiss. LA, Raghavachari K .... 46. a) Dorofeeva OV, Iorish VS, Moiseeva NF (1999) J Chem. Eng Data 44:516;...

305

Large size fibrillar bundles of the Alzheimer amyloid b-protein  

Science Conference Proceedings (OSTI)

StokesEinstein relation: kBTD1 = 6pgRh, where kB is the. Boltzmann constant ..... height hc and the aggregation number nf are less robust parameters, since...

306

Carbon Free Developments | Open Energy Information  

Open Energy Info (EERE)

Developments Jump to: navigation, search Name Carbon Free Developments Place United Kingdom Zip W11 3NF Sector Wind energy Product UK-based onshore wind project developer. The firm...

307

Project Title  

NLE Websites -- All DOE Office Websites (Extended Search)

plant possible * Other options: - Agricultural and potable water for local use - Saline cooling towers * Use softened water from NF - Saline oil-field make-up waters (11 wt %...

308

The NOAA Hydrometeorology Testbed Soil Moisture Observing Networks: Design, Instrumentation, and Preliminary Results  

Science Conference Proceedings (OSTI)

The NOAA Hydrometeorology Testbed (HMT) program has deployed soil moisture observing networks in the watersheds of the Russian River and the North Fork (NF) of the American River in northern California, and the San Pedro River in southeastern ...

Robert J. Zamora; F. Martin Ralph; Edward Clark; Timothy Schneider

2011-09-01T23:59:59.000Z

309

S:\VM3\RX97\TBL_LIST.WPD  

U.S. Energy Information Administration (EIA) Indexed Site

b. Housing Unit Characteristics by Four Most Populated States, b. Housing Unit Characteristics by Four Most Populated States, Percent of U.S. Households, 1997 Housing Unit Characteristics RSE Column Factor: Total Four Most Populated States RSE Row Factors New York California Texas Florida 0.4 1.1 1.1 1.2 1.7 Total .............................................................. 100.0 100.0 100.0 100.0 100.0 0.0 Census Region and Division Northeast ..................................................... 19.4 100.0 -- -- -- NF New England ............................................. 5.2 Q -- -- -- NF Middle Atlantic ........................................... 14.2 100.0 -- -- -- NF Midwest ....................................................... 23.7 -- -- -- -- NF East North Central ..................................... 16.7 --

310

Improved nuclear matter calculations from chiral low-momentum interactions  

Science Conference Proceedings (OSTI)

We present nuclear matter calculations based on low-momentum interactions derived from chiral effective field theory potentials. The current calculations use an improved treatment of the three-nucleon force (3NF) contribution that includes a corrected combinatorial factor beyond Hartree-Fock that was omitted in previous nuclear matter calculations. We find realistic saturation properties using parameters fit only to few-body data, but with larger uncertainty estimates from cutoff dependence and the 3NF parametrization than in previous calculations.

Hebeler, K. [TRIUMF, 4004 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2A3 (Canada); Department of Physics, Ohio State University, Columbus, Ohio 43210 (United States); Bogner, S. K. [National Superconducting Cyclotron Laboratory and Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan 48844 (United States); Furnstahl, R. J. [Department of Physics, Ohio State University, Columbus, Ohio 43210 (United States); Nogga, A. [Institute for Advanced Simulations, Institut fuer Kernphysik and Juelich Centre for Hadron Physics, Forschungszentrum Juelich, D-52425 Juelich (Germany); Schwenk, A. [ExtreMe Matter Institute EMMI, GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, D-64291 Darmstadt (Germany); Institut fuer Kernphysik, Technische Universitaet Darmstadt, D-64289 Darmstadt (Germany)

2011-03-15T23:59:59.000Z

311

1. "Kopfzahlen" -Insgesamt Studienanfnger im 1. Hochschulsem. 527 605 613 545 433  

E-Print Network (OSTI)

- - Gesamt 0 0 0 39 908 921 1.107 1.200 Chemie Biochemie * Bachelor - - - - 37 - - - Chemie Bachelor KF - 4 6.309 Deutsch als Bachelor KF 44 37 32 - 185 119 67 - Fremdsprache Bachelor NF 10 15 11 - 46 37 18 - (Interkult(42) 50(50) 120 - 860 681 492 - Deutsch Bachelor NF 17(15) 14 (10) 35 - 184 136 107 - Gesamt 61 64 155 188

Moeller, Ralf

312

NETL: Water-Energy Interface - Power Plant Water Management  

NLE Websites -- All DOE Office Websites (Extended Search)

Nanofiltration Treatment Options for Thermoelectric Power Plant Water Treatment Demands Nanofiltration Treatment Options for Thermoelectric Power Plant Water Treatment Demands Sandia National Laboratories (SNL) is conducting a study on the use of nanofiltration (NF) treatment options to enable use of non-traditional water sources as an alternative to freshwater make-up for thermoelectric power plants. The project includes a technical and economic evaluation of NF for two types of water that contain moderate to high levels of total dissolved solids (TDS): (1) cooling tower recirculating water and (2) produced waters from oil & gas extraction operations. Reverse osmosis (RO) is the most mature and commonly considered option for high TDS water treatment. However, RO is generally considered to be too expensive to make treatment of produced waters for power plant use a feasible application. Therefore, SNL is investigating the use of NF, which could be a more cost effective treatment option than RO. Similar to RO, NF is a membrane-based process. Although NF is not as effective as RO for the removal of TDS (typical salt rejection is ~85 percent, compared to >95 percent for RO), its performance should be sufficient for typical power plant applications. In addition to its lower capital cost, an NF system should have lower operating costs because it requires less pressure to achieve an equivalent flux of product water.

313

Activation of endothelial-leukocyte adhesion molecule 1 (ELAM-1) gene transcription  

SciTech Connect

Leukocyte adherence to endothelium is in part mediated by the transient expression of endothelial-leukocyte adhesion molecule 1 (ELAM-1) on endothelial surfaces stimulated by tumor necrosis factor {alpha} (TNF), interleukin (IL) 1, or bacterial lipopolysaccharide (LPS). The intracellular factors controlling induction of ELAM-1 mRNA and protein are unknown. In nuclear runoff experiments with cultured human umbilical vein endothelial cells (HUVEC), the authors demonstrate that transcriptional activation of the ELAM-1 gene occurs following stimulation with TNF. Sequence analysis of the 5{prime} flanking region of the ELAM-1 gene reveals consensus DNA-binding sequences for two known transcription factors, NF-{kappa}B and AP-1. Gel mobility shift assays demonstrate that TNF, IL-1, or LPS induces activation of NF-{kappa}B-like DNA binding activity in HUVEC. Phorbol 12-myristate 13-acetate, a known activator of protein kinase C (PKC), weakly induces NF-{kappa}B-like activity, ELAM-1 mRNA, and ELAM-1 surface expression in HUVEC. However, TNF, IL-1, and LPS do not activate PKC in HUVEC at doses that strongly induce NF-{kappa}B-like protein activation and ELAM-1 gene expression. PKC blockade with H7 does not inhibit activation of these NF-kB-like proteins but does inhibit ELAM-1 gene transcription. They conclude that PKC-independent activation of NF-{kappa}B in HUVEC with TNF, IL-1, or LPS is associated with, but not sufficient for, activation of ELAM-1 gene transcription.

Montgomery, K.F.; Tarr, P.I.; Bomsztyk, K.; Harlan, J.M.; Pohlman, T.H. (Univ. of Washington, Seattle (United States)); Osborn, L.; Hession, C.; Tizard, R.; Goff, D.; Vassallo, C.; Lobb, R. (Biogen, Inc., Cambridge, MA (United States))

1991-08-01T23:59:59.000Z

314

Activation of nuclear factor kB in human lymphoblastoid cells by low-dose ionizing radiation  

SciTech Connect

Nuclear factor kB (NF-kB) is a pleiotropic transcription factor which is involved in the transcriptional regulation of several specific genes. Recent reports demonstrated that ionizing radiation in the dose range of 2-50 Gy results in expression of NF-kB in human KG-1 myeloid leukemia cells and human B-lymphocyte precursor cells; the precise mechanism involved and the significance are not yet known. The present report demonstrates that even lower doses of ionizing radiation, 0.25-2.0 Gy, are capable of inducing expression of NF-kB in EBV-transformed 244B human lymphoblastoid cells. These results are in a dose range where the viability of the cells remains very high. After exposure to {sup 137}Cs {gamma} rays at a dose rate of 1.17 Gy/min, a maximum in expression of NF-kB was seen at 8 h after a 0.5-Gy exposure. Time-course studies revealed a biphasic time-dependent expression after 0.5-, 1- and 2-Gy exposures. However, for each time examined, the expression of NF-kB was maximum after the 0.5-Gy exposure. The expression of the p50 and p65 NF-kB subunits was also shown to be regulated differentially after exposures to 1.0 and 2.0 Gy. 32 refs., 3 figs.

Prasad, A.V.; Mohan, N.; Meltz, M.L.; Chandrasekar, B. [Univ. of Texas Health Science Center, San Antonio, TX (United States)

1994-06-01T23:59:59.000Z

315

Conformal Window and Correlation Functions in Lattice Conformal QCD  

E-Print Network (OSTI)

We discuss various aspects of Conformal Field Theories on the Lattice. We mainly investigate the SU(3) gauge theory with N_f degenerate fermions in the fundamental representation, employing the one-plaquette gauge action and the Wilson fermion action. First we make a brief review of our previous works and thereby clarify the reason why we conjecture that the conformal window is 7 le N_f le 16. Secondly, we introduce a new concept, "conformal theories with an IR cutoff" and point out that any numerical simulation on a lattice is bounded by an IR cutoff Lambda_{IR}. Then we make predictions that when N_f is within the conformal window, the propagator of a meson G(t) behaves at large t, as G(t) = c exp(-m_H t)/t^alpha, that is, a modified Yukawa-type decay form, instead of the usual exponential decay form in the small quark mass region. This holds on an any lattice for any coupling constant g, as far as g is between 0 and g^*, where g^* is the IR fixed point. We verify that numerical results really satisfy the predictions for the N_f=7 case and the N_f=16 case. Thirdly, we discuss small number of flavors (N_f=2 sim 6) QCD at finite temperatures. We point out theoretically and verify numerically that the correlation functions at T/T_c > 1 exhibit the characteristics of the conformal function with IR cutoff, an exponential decay with power correction. Further, we observe our data are consistent with the picture that the N_f=7 case and the N_f=2 at T sim 2 T_c case are close to the meson unparticle model, and we estimate gamma^* = 1.2(1). On the other hand, the N_f=16 case and the N_f=2 at T= 10^2 sim 10^5 Tc cases are close to a free state in the Z(3) twisted vacuum. The results give clues for long standing issues such as slow approach of the free energy to the Stefan-Boltzmann ideal gas limit.

Y. Iwasaki

2012-12-18T23:59:59.000Z

316

Genotoxicity of complex chemical mixtures  

E-Print Network (OSTI)

Complex chemical mixtures are ubiquitous in the environment. Humans are frequently exposed to these mixtures; therefore, it is important to understand potential interactions of chemical mixtures. Mixture interactions may influence the absorption, distribution, metabolism or excretion of the components of a complex mixture. The research conducted for this dissertation has coupled chemical fractionation with in vitro and in vivo bioassays to assess the potential carcinogenic risk of complex mixtures. A non-aqueous phase liquid from a wood treatment plant was separated into acid (AF), base (BF) and neutral fractions (NF). The NF was further enriched using column chromatography to produce a polychlorinated dinbenzo-p-dioxin (PCDD) and a polycyclic aromatic hydrocarbon (PAH) fraction. The genotoxicity of these mixtures were assessed via analytical quantification, in vitro (Salmonella microsome and E. coli prophage induction) and in vivo (32P-postlabeling) bioassays. The NF was further tested to measure bulky DNA adducts and induction of tumor formation. The AF contained the highest level of pentachlorophenol and the highest concentration of total PAHs. Although the carcinogenic PAHs were highest in the PCDD fraction, the highest concentrations of benzo(a)pyrene (BAP), indeno(1,2,3-cd)pyrene and dibenz(a,h)anthracene were detected in the PAH fraction. A positive genotoxic response in Salmonella was induced by the crude extract, the PAH and BF, whereas the AF and BF induced a positive response in the E. coli assay. In vivo, the PAH fraction induced the highest DNA adduct frequencies in the lung. The NF, reconstituted mixture (RM) (which includes equivalent concentrations of seven carcinogenic PAHs in the NF), BAP and the NF amended with BAP (NF+BAP) were all tested in an infant mouse model. At the highest dose, after a 24 hr exposure, NF+BAP had the highest total DNA adducts measured in liver which was three to seven times higher than with other treatments. Adduct levels were comparable to the control after 280 days. The highest incidence of tumors was observed in the liver. At the high dose, NF+BAP elicited the highest incidence of tumors. The results of this research confirm previous studies and indicate that the carcinogenic potential of PAH mixtures may be greater than predicted by chemical analysis.

Phillips, Tracie Denise

2006-12-01T23:59:59.000Z

317

Life Cycle Nitrogen Trifluoride Emissions from Photovoltaics  

SciTech Connect

Amorphous- and nanocrystalline-silicon thin-film photovoltaic modules are made in high-throughput manufacturing lines that necessitate quickly cleaning the reactor. Using NF{sub 3}, a potent greenhouse gas, as the cleaning agent triggered concerns as recent reports reveal that the atmospheric concentrations of this gas have increased significantly. We quantified the life-cycle emissions of NF{sub 3} in photovoltaic (PV) manufacturing, on the basis of actual measurements at the facilities of a major producer of NF{sub 3} and of a manufacturer of PV end-use equipment. From these, we defined the best practices and technologies that are the most likely to keep worldwide atmospheric concentrations of NF{sub 3} at very low radiative forcing levels. For the average U.S. insolation and electricity-grid conditions, the greenhouse gas (GHG) emissions from manufacturing and using NF{sub 3} in current PV a-Si and tandem a-Si/nc-Si facilities add 2 and 7 g CO{sub 2eq}/kWh, which can be displaced within the first 1-4 months of the PV system life.

Fthenakis, V.

2010-10-25T23:59:59.000Z

318

USFS Humboldt-Toiyabe National Forest | Open Energy Information  

Open Energy Info (EERE)

USFS Humboldt-Toiyabe National Forest USFS Humboldt-Toiyabe National Forest Jump to: navigation, search Name USFS Humboldt-Toiyabe National Forest Short Name Humbolt-Toiyabe NF Parent Organization United States Forest Service Address 1200 Franklin Way Place Sparks, NV Zip 89431 Phone number (775) 331-6444 Website http://www.fs.usda.gov/main/ht References Humboldt-Toiyabe NF Website[1] This article is a stub. You can help OpenEI by expanding it. USFS Toiyabe National Forest is an organization based in Sparks, Nevada, Sparks, Nevada. References ↑ "Humboldt-Toiyabe NF Website" Retrieved from "http://en.openei.org/w/index.php?title=USFS_Humboldt-Toiyabe_National_Forest&oldid=640692" Categories: Government Agencies Stubs What links here Related changes Special pages Printable version

319

Low Dose Radiation Research Program: Molecular Characterization of Survival  

NLE Websites -- All DOE Office Websites (Extended Search)

Survival Advantage, Bystander Effect, and Survival Advantage, Bystander Effect, and Genomic Instability after Low-LET Low Dose Radiation Exposure Mohan Natarajan University of Texas Health Science Center Why this Project? To understand the molecular link between the activation of NF-kB and cellular outcomes such as better cell survival after low-LET radiation and to determine whether low dose radiation-induced NF-kB signaling can mediate telomerase activation and thus confer enhanced cell survival of normal aortic endothelial cells. Project Goals To determine whether low-linear energy transfer (LET) radiation can cause a positive feedback signal initiated by the activation of the NF-kB. To examine one of the mechanisms involving TNF-a as a signaling mediator, which could mediate the bystander effect through the generation

320

Low Dose Radiation Research Program: Radiation-Induced Nuclear Factor kB  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation-Induced Nuclear Factor kB mediates survival advantage by Radiation-Induced Nuclear Factor kB mediates survival advantage by Telomerase Activation. Authors: Natarajan M.,1 Mohan S.,2 Pandeswara, S.L.,1 and Herman T.S.1 Institutions: Departments of 1Radiation Oncology and 2Pathology, The University of Texas Health Science Center, San Antonio, Texas Activation of NF-kB in response to low doses of ionizing radiation was first shown in our laboratory. Although studies have shown that NF-kB plays an important role in anti-apoptotic function, little has been done to understand the molecular link between the activation of NF-kB and cellular outcome such as enhanced cell survival after low dose low-linear transfer (LET) radiation. Because upregulation of telomerase activity is associated with longevity and allows cells to escape from senescence, we hypothesize

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
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We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

EIS-0350-S1: Mitigation Action Plan | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Mitigation Action Plan Mitigation Action Plan EIS-0350-S1: Mitigation Action Plan Nuclear Facility Portion of the Chemistry and Metallurgy Research Building Replacement Project at Los Alamos National Laboratory, Los Alamos, NM This Mitigation Action Plan (MAP) describes mitigation and monitoring commitments for constructing and operating the Modified CMRR-NF. The commitments made in this MAP are designed to mitigate potentially adverse environmental consequences associated with the CMRR-NF Project as the CMRR-NF is constructed and operated, and as direct, indirect, and cumulative impacts from these actions occur over time. EIS-0350-S1-MAP-2011.pdf More Documents & Publications EIS-0350-S1: Final Supplemental Environmental Impact Statement EIS-0350-S1: Draft Supplemental Environmental Impact Statement

322

A Variable flavor number scheme for heavy quark production at small x.  

E-Print Network (OSTI)

flavour contribution to the proton structure functions {Fa} can be written as: Fa,H = 1 nf nf ? i=1 e2i [ (CNSa,qq + CPSa,qq)? ? + CSa,qg ? g + nfCNSa,qq ? qns ] + e2H [ CPSa,Hq ? ?+ CSa,Hg ? g ] , (1) 3Here we are concerned with heavy quarks which... are generated perturbatively, as opposed to intrinsic heavy flavour distri- butions, which would be present in the proton at all values of Q2 [25]. 2 Coefficient Order CSa,Hg O(?S) CPSa,Hq O(?2S) CPS,NS,Sa,qq O(?2S) CSa,qg O(?3S) Table 1: The leading order...

White, C D; Thorne, Robert S

323

Atmospheric Chemistry and Physics  

E-Print Network (OSTI)

Abstract. A 3-D chemistry-transport model has been applied to the Mexico City metropolitan area to investigate the origin of elevated levels of non-fossil (NF) carbonaceous aerosols observed in this highly urbanized region. High time resolution measurements of the fine aerosol concentration and composition, and 12 or 24 h integrated 14 C measurements of aerosol modern carbon have been performed in and near Mexico City during the March 2006 MILAGRO field experiment. The non-fossil carbon fraction (fNF), which is lower than the measured modern fraction (fM) due to the elevated 14 C in the atmosphere caused by nuclear bomb testing, is estimated from the measured fM and the source-dependent information on modern carbon enrichment. The fNF contained in PM1 total carbon analyzed by a US team (f TC

unknown authors

2010-01-01T23:59:59.000Z

324

On the spectrum of QCD-like theories and the conformal window  

E-Print Network (OSTI)

We report on the spectrum of the SU(3) gauge theory with twelve flavours in the fundamental representation of the gauge group. We isolate distinctive features of the hadronic phase - the one proper of QCD at zero temperature - and the so called conformal phase. The latter should emerge at sufficiently large Nf and before the loss of asymptotic freedom. In particular, we analyse available lattice data for the spectrum of Nf=12 and include a comparison with results with Nf=16; the latter theory, predicted by the perturbative beta-function to develop an IRFP and therefore be in the conformal phase, can serve as a paradigm for the study of theories in the conformal window. Our analysis suggests that the theory with twelve flavours is in the conformal window, possibly close to its lower boundary.

Albert Deuzeman; Maria Paola Lombardo; Elisabetta Pallante

2012-01-09T23:59:59.000Z

325

The Nuclear Factor-kB Pathway Regulates Cytochrome P450 3A4 Protein Stability  

SciTech Connect

We have previously observed that CYP3A4 protein levels are suppressed by inhibition of the proteasome in primary cultured hepatocytes. Because this result is opposite of what would be expected if CYP3A4 is degraded by the proteasome, it seems likely that there is another protein that is susceptible to proteasomal degradation that regulates CYP3A4 expression. In this study, we evaluate whether the nuclear factor kappa B (NF-kB) pathway is involved in that process. Our model system uses an adenovirus system to express CYP3A4 protein in HepG2 cells, which are derived from human cancer cells. Similar to results in primary hepatocytes, we found that inhibition of the proteasome with MG132 suppresses CYP3A4. Consistent with reports that proteasome inhibition suppresses the NF-kB pathway, we also observe a suppression of inhibitory kB kinase protein levels after treatment with MG132. Treatment of the HepG2 cells with NK-kB Activation Inhibitor also suppresses CYP3A4 proteins levels. In contrast, inhibition of either the proteasome or NF-kB pathways increases CYP3A4 mRNA levels. When the HepG2 cells are treated with cycloheximide, a general inhibitor of translation, the loss of CYP3A4 protein is accelerated by co-treatment with an NF-kB Activation Inhibitor. These results indicate that NF-kB activity regulates CYP3A4 protein stability and suggest that the NF-kB pathway is responsible for the decrease in CYP3A4 protein levels that results from the inhibition of proteasomal activity.

Zangar, Richard C.; Bollinger, Nikki; Verma, Seema; Karin, Norm J.; Lu, Yi

2008-06-01T23:59:59.000Z

326

Similarity Renormalization Group Evolution of Three-Nucleon Forces in a Hyperspherical Momentum Representation  

E-Print Network (OSTI)

A new framework for computing the Similarity Renormalization Group (SRG) evolution of three-nucleon forces (3NF) in momentum representation is presented. The use of antisymmetric three-particle hyperspherical momentum states ensures unitary evolutions within certain basis truncations, much like antisymmetric harmonic oscillator SRG evolutions. Additionally, in each partial wave the $T_{\\mbox{rel}}$-SRG regulator is exactly represented, similar to recent 3NF momentum representation evolutions. Unitary equivalence is demonstrated for the triton using several chiral two- plus three-nucleon interactions. This method allows for a clean visualization of the evolution of the three-nucleon forces, which manifests the SRG decoupling pattern and low-momentum universality.

Kyle A. Wendt

2013-04-04T23:59:59.000Z

327

Report on thermal aging effects on tensile properties of ferritic-martensitic steels.  

Science Conference Proceedings (OSTI)

This report provides an update on the evaluation of thermal-aging induced degradation of tensile properties of advanced ferritic-martensitic steels. The report is the first deliverable (level 3) in FY11 (M3A11AN04030103), under the Work Package A-11AN040301, 'Advanced Alloy Testing' performed by Argonne National Laboratory, as part of Advanced Structural Materials Program for the Advanced Reactor Concepts. This work package supports the advanced structural materials development by providing tensile data on aged alloys and a mechanistic model, validated by experiments, with a predictive capability on long-term performance. The scope of work is to evaluate the effect of thermal aging on the tensile properties of advanced alloys such as ferritic-martensitic steels, mod.9Cr-1Mo, NF616, and advanced austenitic stainless steel, HT-UPS. The aging experiments have been conducted over a temperature of 550-750 C for various time periods to simulate the microstructural changes in the alloys as a function of time at temperature. In addition, a mechanistic model based on thermodynamics and kinetics has been used to address the changes in microstructure of the alloys as a function of time and temperature, which is developed in the companion work package at ANL. The focus of this project is advanced alloy testing and understanding the effects of long-term thermal aging on the tensile properties. Advanced materials examined in this project include ferritic-martensitic steels mod.9Cr-1Mo and NF616, and austenitic steel, HT-UPS. The report summarizes the tensile testing results of thermally-aged mod.9Cr-1Mo, NF616 H1 and NF616 H2 ferritic-martensitic steels. NF616 H1 and NF616 H2 experienced different thermal-mechanical treatments before thermal aging experiments. NF616 H1 was normalized and tempered, and NF616 H2 was normalized and tempered and cold-rolled. By examining these two heats, we evaluated the effects of thermal-mechanical treatments on material microstructures and associated mechanical properties during long-term aging at elevated temperatures. Thermal aging experiments at different temperatures and periods of time have been completed: 550 C for up to 5000 h, 600 C for up to 7500 h, and 650 C for more than 10,000 h. Tensile properties were measured on thermally aged specimens and aging effect on tensile behavior was assessed. Effects of thermal aging on deformation and failure mechanisms were investigated by using in-situ straining technique with simultaneous synchrotron XRD measurements.

Li, M.; Soppet, W.K.; Rink, D.L.; Listwan, J.T.; Natesan, K. (Nuclear Engineering Division)

2012-05-10T23:59:59.000Z

328

Use of nanofiltration to reduce cooling tower water usage.  

SciTech Connect

Nanofiltration (NF) can effectively treat cooling-tower water to reduce water consumption and maximize water usage efficiency of thermoelectric power plants. A pilot is being run to verify theoretical calculations. A side stream of water from a 900 gpm cooling tower is being treated by NF with the permeate returning to the cooling tower and the concentrate being discharged. The membrane efficiency is as high as over 50%. Salt rejection ranges from 77-97% with higher rejection for divalent ions. The pilot has demonstrated a reduction of makeup water of almost 20% and a reduction of discharge of over 50%.

Sanchez, Andres L.; Everett, Randy L.; Jensen, Richard Pearson; Cappelle, Malynda A.; Altman, Susan Jeanne

2010-09-01T23:59:59.000Z

329

Toward a Unified Treatment of Electronic Processes in Organic Semiconductors  

DOE Green Energy (OSTI)

A quantitative study of n-type doping in highly crystalline organic semiconductor films establishes the predominant influence of electrostatic forces in these low-dielectric materials. Based on these findings, a self-consistent model of doped (purposely or not) organic semiconductors is proposed in which: (1) the equilibrium free carrier density, nf, is a small fraction of the total charge density; (2) a superlinear increase in conductivity with doping density is universal; (3) nf increases with applied electric field; and (4) the carrier mobility is field-dependent regardless of crystallinity.

Gregg. B.A.

2005-01-01T23:59:59.000Z

330

Use of nanofiltration to reduce cooling tower water consumption.  

Science Conference Proceedings (OSTI)

Nanofiltration (NF) can effectively treat cooling-tower water to reduce water consumption and maximize water usage efficiency of thermoelectric power plants. A pilot is being run to verify theoretical calculations. A side stream of water from a 900 gpm cooling tower is being treated by NF with the permeate returning to the cooling tower and the concentrate being discharged. The membrane efficiency is as high as over 50%. Salt rejection ranges from 77-97% with higher rejection for divalent ions. The pilot has demonstrated a reduction of makeup water of almost 20% and a reduction of discharge of over 50%.

Altman, Susan Jeanne; Ciferno, Jared

2010-10-01T23:59:59.000Z

331

Newsfront 28 May - 3 June 2007, Issue 18  

E-Print Network (OSTI)

Kathmandu l 28 May-3 June, 2007 l # 18 l Price Rs. 25 Are you tired/sick, physically and men- tally? Why dont you try our Center? We strengthen your body and mind with dynamic human touch using oriental my- thology Our Services: Shitsu ,Anma... . However, Nembwang has saved the UML members by adjourning the House through advance notices. nf correspondent nf correspondent Former U S President Jimmy Carter has saved his statesmans image often at the cost of his own country. But his impending...

Ghimire, Yubaraj

332

Table A37. Total Inputs of Energy for Heat, Power, and Electricity  

U.S. Energy Information Administration (EIA) Indexed Site

2" 2" " (Estimates in Trillion Btu)" ,,,,,,,"Coal" ,,,,"Distillate",,,"(excluding" ,,,,"Fuel Oil",,,"Coal Coke",,"RSE" ,,"Net","Residual","and Diesel",,,"and",,"Row" "End-Use Categories","Total","Electricity(a)","Fuel Oil","Fuel(b)","Natural Gas(c)","LPG","Breeze)","Other(d)","Factors" "Total United States" "RSE Column Factors:","NF",0.4,1.6,1.5,0.7,1,1.6,"NF" "TOTAL INPUTS",15027,2370,414,139,5506,105,1184,5309,3 "Boiler Fuel","--","W",296,40,2098,18,859,"--",3.6

333

Table A11. Total Inputs of Energy for Heat, Power, and Electricity Generatio  

U.S. Energy Information Administration (EIA) Indexed Site

2" 2" " (Estimates in Trillion Btu)" ,,,,,,,"Coal" ,,,,"Distillate",,,"(excluding" ,,,,"Fuel Oil",,,"Coal Coke",,"RSE" ,,"Net","Residual","and Diesel",,,"and",,"Row" "End-Use Categories","Total","Electricity(a)","Fuel Oil","Fuel(b)","Natural Gas(c)","LPG","Breeze)","Other(d)","Factors" ,"Total United States" "RSE Column Factors:"," NF",0.5,1.3,1.4,0.8,1.2,1.2," NF" "TOTAL INPUTS",16515,2656,441,152,6141,99,1198,5828,2.7 "Indirect Uses-Boiler Fuel"," --",28,313,42,2396,15,875," --",4

334

Timed CSP and Object-Z John Derrick  

E-Print Network (OSTI)

Timed CSP and Object-Z John Derrick Computing Laboratory, University of Kent, Canterbury, CT2 7NF a simple integration of timed CSP and Object-Z. Following existing work, the components in such an inte- gration are written as either Object-Z classes, or timed CSP processes, and are combined together using

Kent, University of

335

Short Desc Long Desc Short Desc Long Desc Short Desc Long Desc Short Desc Long Desc 401k 401k D PP PT2 Dental Pre-Paid PT 2 Misc Miscellaneous Deductions ROTH ROTH 401(k)  

E-Print Network (OSTI)

FICA Additional Medicare Tax ORP ING1 ORP Retirement ING 10% TCRS NF TCRS Retirement Non-Faculty AFLACSIC Aflac - Sickness Indemnity Foundat Foundation ORP ING2 ORP Retirement ING Two Split TCRS TCB Closed Teacher Class B Contrib AFLCIEET Aflac - Critical ILL-EE-Tobacco Foundat ETSU Foundation ORP ING3

Karsai, Istvan

336

Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor  

Science Conference Proceedings (OSTI)

The merlin-1 tumor suppressor is encoded by the Neurofibromatosis-2 (Nf2) gene and loss-of-function Nf2 mutations lead to nervous system tumors in man and to several tumor types in mice. Merlin is an ERM (ezrin, radixin, moesin) family cytoskeletal protein that interacts with other ERM proteins and with components of cell-cell adherens junctions (AJs). Merlin stabilizes the links of AJs to the actin cytoskeleton. Thus, its loss destabilizes AJs, promoting cell migration and invasion, which in Nf2{sup +/-} mice leads to highly metastatic tumors. Paradoxically, the 'closed' conformation of merlin-1, where its N-terminal four-point-one, ezrin, radixin, moesin (FERM) domain binds to its C-terminal tail domain, directs its tumor suppressor functions. Here we report the crystal structure of the human merlin-1 head domain when crystallized in the presence of its tail domain. Remarkably, unlike other ERM head-tail interactions, this structure suggests that binding of the tail provokes dimerization and dynamic movement and unfurling of the F2 motif of the FERM domain. We conclude the 'closed' tumor suppressor conformer of merlin-1 is in fact an 'open' dimer whose functions are disabled by Nf2 mutations that disrupt this architecture.

Yogesha, S.D.; Sharff, Andrew J.; Giovannini, Marco; Bricogne, Gerard; Izard, Tina (House Ear); (Globel Phasing); (Scripps)

2012-03-26T23:59:59.000Z

337

Power-aware multiband-multistandard CMOS receiver system-level budgeting  

Science Conference Proceedings (OSTI)

A systematic system-level design methodology for multiband-multistandard (MB-MS) wideband/reconfigurable CMOS receivers is presented. The methodology determines the specifications (noise figure (NF) and linearity) for each building block to minimize ... Keywords: multiband-multistandard (MB-MS) CMOS receiver, power consumption, system-level budgeting

Mohamed El-Nozahi; Edgar Snchez-Sinencio; Kamran Entesari

2009-07-01T23:59:59.000Z

338

Design Ensemble Machine Learning Model for Breast Cancer Diagnosis  

Science Conference Proceedings (OSTI)

In this paper, we classify the breast cancer of medical diagnostic data. Information gain has been adapted for feature selections. Neural fuzzy (NF), k-nearest neighbor (KNN), quadratic classifier (QC), each single model scheme as well as their associated, ... Keywords: Ensemble learning, Information gain, KNN, Neural fuzzy, Quadratic classifier

Sheau-Ling Hsieh; Sung-Huai Hsieh; Po-Hsun Cheng; Chi-Huang Chen; Kai-Ping Hsu; I-Shun Lee; Zhenyu Wang; Feipei Lai

2012-10-01T23:59:59.000Z

339

INTRODUCTION Neural intermediate filaments (NIF) containing one or more of  

E-Print Network (OSTI)

INTRODUCTION Neural intermediate filaments (NIF) containing one or more of five different types, NIF possess common structural features, including a conserved alpha-helical central rod domain of NIF in the presence of NF-L (Zackroff et al., 1982; Hisanaga and Hirokawa, 1988; Balin and Lee, 1991

Goldman, Robert D.

340

Career Options Program/Courses Resources Why Choose Electrical Engineering  

E-Print Network (OSTI)

. · Telecommunications. · Design things that people use. · Computers, personal electronics. · Cars, planes etc. (e. · Biomedical. · Micro-hydro (see http://www.ieee.org/portal/ieeetv/ viewer.html?progId=124039) · Help people #12;Career Options Program/Courses Resources Employers Utilities NL Hydro, NF Power, Aliant, Ontario

Peters, Dennis

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
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341

Khesbn no. 71-72 - April 1973 - Journal  

E-Print Network (OSTI)

trlg tjih tJlr",rynNt t. ,l}ttl, os,l] -,Nf l,yblll) lylllh . ]lN) fUltP:yly;7, lty? ttl tt'1h btfybyf lln l)'! ]ylN i7! ilrS:! 1t1 yt ! '1tr tTl ,:tN -lylnyiz ! t? y,,ryF'D,

Admin, LAYCC

1973-01-01T23:59:59.000Z

342

Page 1; D.W. Marcouiller, Full CV September 2011 Curriculum Vitae  

E-Print Network (OSTI)

Page 1; D.W. Marcouiller, Full CV ­ September 2011 Curriculum Vitae DAVID WILLIAM MARCOUILLER, Ph Perce NF (Dixie, ID.) II. RESEARCH AND PUBLICATIONS A. Textbooks Marcouiller, D.W., M.L.Lapping, O the "Haves" and the "Have Nots". Surrey, UK: Ashgate Publishing. Green, G.P., S.C. Deller, and D.W

Mladenoff, David

343

Evolution of Persistent Wave Groups  

Science Conference Proceedings (OSTI)

During the near-field leg of the Hawaiian Ocean-Mixing Experiment (HOME-NF), short, steep surface wave groups were observed that elicited strong group-forced responses in the wave-filtered surface current field, as reported by Smith. Some of ...

Jerome A. Smith; Coralie Brulefert

2010-01-01T23:59:59.000Z

344

175 C 200 C 225 C 250 C 275 C DegradedH20consumed(L/kWh)  

E-Print Network (OSTI)

. William Glassley (bill.glassley@nf.au.dk) Dr. Sonia Yeh (slyeh@ucdavis.edu) 1. INTRODUCTION · Geothermal be conducted, including analysis of water usage in geothermal electricity production. · This study assesses the water requirements of producing geothermal electricity from: (1) hydrothermal resources producing hot

California at Davis, University of

345

Production and characterisation of hydroxyapatite/multi-walled carbon nanotube composites  

E-Print Network (OSTI)

by adding the CNTs to the Ca(OH)2 solution as the HA was precipitating. Both as-made (nfCNTs) and acid-treated CNTs (fCNTs) were used to make composites with loadings of 0.5 5 wt.% CNTs. The resulting slurry was shear mixed and then processed to make a...

White, Ashley Ann

2010-01-12T23:59:59.000Z

346

d'ordre : 88-2008 Annee 2008 presentee et soutenue publiquement pour l'obtention du  

E-Print Network (OSTI)

) (Aptel et coll., 2002). 5 tel-00335098,version1-28Oct2008 #12;I. ´Etude bibliographique OsmoseinverseNanofiltrationUltrafiltrationMicrofiltration), ul- trafiltration (UF), microfiltration (MF)), certaines caract´eristiques (mat´eriau, g fil- tration membranaire : osmose inverse (OI), nanofiltration (NF), ultrafiltration (UF) et

Paris-Sud XI, Université de

347

Colloidal Fouling of Reverse Osmosis Membranes  

E-Print Network (OSTI)

. For the tests involving foulant mass measurements and effect of surfactants, a predetermined initial flux to distinguish between two cases. For RO, nanofiltration (NF), and perhaps "tight" ultrafiltration (UF) membranes and, thus, reduces the product water flux (4). For microfiltration (MF) membranes, pore plugging

Elimelech, Menachem

348

SELECTING FUELS WITHIN ENVIRONMENTAL IMPACT REQUIREMENTS: CONVERTING A  

E-Print Network (OSTI)

SELECTING FUELS WITHIN ENVIRONMENTAL IMPACT REQUIREMENTS: CONVERTING A PRESENT COMBUSTION SYSTEM fossil fuels. Next, the alternative fuels with large po tential energy recovery are selected and presentDIIsrCDUICTOI SCIIU, ! i ItFUS£_pu- ;1II-'NfU1MTJ: 'U.)'// PIr I It \\I I ' I Ir-SUIIDDU\\N. £DI

Columbia University

349

DOE/EIA-0202(84/3Q) Short-Term Energy Outlook  

Annual Energy Outlook 2012 (EIA)

CN-H'-H cooin rjincN r *-i r oscoco fO -* -( jJ CO CO CO *I" CNCNCN rOCNCN sC >-* vn n CN O csicNfN T-T IiS OCNCO vOfN-< fOOO JO C OCOCO COfNsO inCOCT...

350

Radiation-induced gene responses  

SciTech Connect

In the process of identifying genes that are differentially regulated in cells exposed to ultraviolet radiation (UV), we identified a transcript that was repressed following the exposure of cells to a combination of UV and salicylate, a known inhibitor of NF-kappaB. Sequencing this band determined that it has identify to lactate dehydrogenase, and Northern blots confirmed the initial expression pattern. Analysis of the sequence of the LDH 5` region established the presence of NF-kappaB, Sp1, and two Ap-2 elements; two partial AP- 1; one partial RE, and two halves of E-UV elements were also found. Electromobility shift assays were then performed for the AP-1, NF- kappaB, and E-UV elements. These experiments revealed that binding to NF-kappaB was induced by UV but repressed with salicylic acid; UV did not affect AP-1 binding, but salicylic acid inhibited it alone or following UV exposure; and E-UV binding was repressed by UV, and salicylic acid had little effect. Since the binding of no single element correlated with the expression pattern of LDH, it is likely that multiple elements govern UV/salicylate-mediated expression.

Woloschak, G.E.; Paunesku, T.; Shearin-Jones, P.; Oryhon, J.

1996-12-31T23:59:59.000Z

351

Identification of cis-acting sequences responsible for phorbol ester induction of human serum amyloid A gene expression via a nuclear factor kB-like transcription factor  

Science Conference Proceedings (OSTI)

The authors have analyzed the 5'-flanking region of one of the genes coding for the human acute-phase protein, serum amyloid A (SAA). They found that SAA mRNA could be increased fivefold in transfected cells by treatment with phorbol 12-myristate 13-acetate (PMA). To analyze this observation further, they placed a 265-base-pair 5' SAA fragment upstream of the reporter chloramphenicol acetyltransferase (CAT) gene and transfected this construct into HeLa cells. PMA treatment of these transient transfectants resulted in increased CAT expression. Nuclear proteins from PMA-treated HeLa cells bound to this DNA fragment, and methylation interference analysis showed that the binding was specific to the sequence GGGACTTTCC (between -82 and -91), a sequence previously described by others as the binding site for the nuclear factor NF/kappa/B. In a cotransfection competition experiment, they could abolish PMA-induced CAT activity by using cloned human immunodeficiency virus long-terminal-repeat DNA containing the NF/kappa/B-binding sequence. The same long-terminal-repeat DNA containing mutant NF/kappa/B-binding sequences did not affect CAT expression, which suggested that binding by an NF/kappa/B-like factor is required for increased SAA transcription.

Edbrooke, M.R.; Cheshire, J.K.; Woo, P.; Burt, B.W.

1989-05-01T23:59:59.000Z

352

Nepali Aawaz Volume 1, Issue 15, 7 June 2006  

E-Print Network (OSTI)

O{x/sf] dxfg kj{df z'esfdgf JoSt ug'{ eof] . pSt sfo{s|ddf g]kfn ls/ft /fO{ P;f]l;P;g ckmo"P;P sL ;+:yfks ;b:o ;'hftf /fO{ -Sofgf8f_, 8f k|1f /fO{, 8f k]/] hf]zfL, 8f tf/f lg/f}nf, 8f ks+h /fO{, OlGhlgo/ k|efs/ /fO{, clwjStf ;'/]z rfdln , o'jf ufos p... ]nf8Lx?nfO k|z+;f kq ljt/0f ug'{ eof] . o"jf ufos pTtd /fO{nfO Members of the Kirant Rai Association celebrate traditional festivals in New York l;h{gf ;'Aafn] k|z+;f kq ljt/0f ug{' ePsf] lyof] . pSt sfo{s|dsf] bf];|f] r/0fdf HofS;g xfO6l:yt /]8...

Shrestha, Kashish Das

353

This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research  

E-Print Network (OSTI)

, the higher operational temperature and longer reactor exposure under intense radiation fields brings new to the author for internal non-commercial research and education use, including for instruction at the authors's personal copy In situ study of heavy ion induced radiation damage in NF616 (P92) alloy Cem Topbasi a

Motta, Arthur T.

354

Genus one correction to Seiberg-Witten prepotential from \\beta-deformed matrix model  

E-Print Network (OSTI)

We study \\beta-deformed matrix models with Penner type potentials, which correspond to N=2 SU(2) supersymmetric gauge theories with N_F=2,3, and 4 flavors. We compute explicitly the genus one corrections to the free energy of the matrix model and show that they match the corresponding results obtained from the Nekrasov partition function.

Baek, Jong-Hyun

2013-01-01T23:59:59.000Z

355

Acetylation of MEK2 and I B kinase (IKK) activation loop residues by YopJ inhibits signaling  

E-Print Network (OSTI)

Acetylation of MEK2 and I B kinase (IKK) activation loop residues by YopJ inhibits signaling Rohit modifi- cation prevents the phosphorylation of these serine residues that is required for activation residue in the activation loop of both the and subunits of the NF- B pathway kinase, IKK. These results

McMahon, Harvey

356

Managed by UT-Battelle for the Department of Energy  

E-Print Network (OSTI)

require extensive support facilities. 1. Mercury Containment 2. Hot Cell / Remote Handling 3. Ventilation change-out and process equipment maintenance is designed to be fully remote. Thus, · The SNS hot cell by UT-Battelle for the Department of Energy NF-IDS Meeting 15 Dec 08 4. Waste Handling · All hot cell

McDonald, Kirk

357

Arsenite enhances tumor necrosis factor-{alpha}-induced expression of vascular cell adhesion molecule-1  

Science Conference Proceedings (OSTI)

Epidemiological studies demonstrated a high association of vascular diseases with arsenite exposure. We hypothesize that arsenite potentiates the effect of proinflammatory cytokines on vascular endothelial cells, and hence contributes to atherosclerosis. In this study, we investigated the effect of arsenite and its induction of glutathione (GSH) on vascular cell adhesion molecule-1 (VCAM-1) protein expression in human umbilical vein endothelial cells (HUVECs) in response to tumor necrosis factor-{alpha} (TNF-{alpha}), a typical proinflammatory cytokine. Our study demonstrated that arsenite pretreatment potentiated the TNF-{alpha}-induced VCAM-1 expression with up-regulations of both activator protein-1 (AP-1) and nuclear factor-{kappa}B (NF-{kappa}B). To elucidate the role of GSH in regulation of AP-1, NF-{kappa}B, and VCAM-1 expression, we employed L-buthionine (S,R)-sulfoximine (BSO), a specific {gamma}-glutamylcysteine synthetase ({gamma}-GCS) inhibitor, to block intracellular GSH synthesis. Our investigation revealed that, by depleting GSH, arsenite attenuated the TNF-{alpha}-induced VCAM-1 expression as well as a potentiation of AP-1 and an attenuation of NF-{kappa}B activations by TNF-{alpha}. Moreover, we found that depletion of GSH would also attenuate the TNF-{alpha}-induced VCAM-1 expression with a down-regulation of the TNF-{alpha}-induced NF-{kappa}B activation and without significant effect on AP-1. On the other hand, the TNF-{alpha}-induced VCAM-1 expression could be completely abolished by inhibition of AP-1 or NF-{kappa}B activity, suggesting that activation of both AP-1 and NF-{kappa}B was necessary for VCAM-1 expression. In summary, we demonstrate that arsenite enhances the TNF-{alpha}-induced VCAM-1 expression in HUVECs via regulation of AP-1 and NF-{kappa}B activities in a GSH-sensitive manner. Our present study suggested a potential mechanism for arsenite in the induction of vascular inflammation and vascular diseases via modulating the actions of proinflammatory cytokines.

Tsou, T.-C. [Division of Environmental Health and Occupational Medicine, National Health Research Institutes, 100 Shih-Chuan 1st Road, Kaohsiung 807, Taiwan (China)]. E-mail: tctsou@nhri.org.tw; Yeh, Szu Ching [Division of Environmental Health and Occupational Medicine, National Health Research Institutes, 100 Shih-Chuan 1st Road, Kaohsiung 807, Taiwan (China); Tsai, E.-M. [Department of Obstetrics and Gynecology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (China); Department of Obstetrics and Gynecology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan (China); Tsai, F.-Y. [Division of Environmental Health and Occupational Medicine, National Health Research Institutes, 100 Shih-Chuan 1st Road, Kaohsiung 807, Taiwan (China); Chao, H.-R. [Department of Environmental and Safety Health Engineering, Chung Hwa College of Medical Technology, Tainan, Taiwan (China); Chang, Louis W. [Division of Environmental Health and Occupational Medicine, National Health Research Institutes, 100 Shih-Chuan 1st Road, Kaohsiung 807, Taiwan (China)

2005-11-15T23:59:59.000Z

358

ANP inhibits TNF-?-induced endothelial MCP-1 expression involvement of p38 MAPK and MKP-1  

E-Print Network (OSTI)

Abstract: Atrial natriuretic peptide (ANP) has been shown to reduce tumor necrosis factor ? (TNF-?)-induced activation of endothelial cells via inhibition of p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-?B pathways. The aim of this study was to determine whether ANP is able to inhibit TNF-?-induced expression of monocyte chemoattractant protein-1 (MCP-1) in endothelial cells and to elucidate the mechanisms involved. Pretreatment of human umbilical vein endothelial cell with ANP significantly reduced TNF-?-induced expression of MCP-1 protein and mRNA. The effects of ANP were shown to be mediated via the guanylyl-cyclase (GC)-coupled A receptor. Activation of the other GC-coupled receptor (natriuretic peptide receptor-B) by the C-type natriuretic peptide as well as activation of soluble GC with S-nitroso-L-glutathione exerted similar effects as ANP, supporting a role for cyclic guanosine monophosphate in the signal transduction. Antisense experiments showed a requirement of MAPK phosphatase-1 (MKP-1) induction and therefore, inhibition of p38 MAPK in the ANPmediated inhibition of TNF-?-induced expression of MCP-1. To investigate a potential interplay between TNF-?-induced activation of p38 MAPK and NF-?B, the p38 MAPK inhibitor SB203580 and a dominant-negative p38 MAPK mutant were used. The results indicated that the blockade of p38 MAPK activity leads to an increased activation of NF-?B and therefore, suggest a counter-regulatory action of p38 MAPK and NF-?B. As antisense experiments revealed a pivotal role for MKP-1 induction and therefore, p38 MAPK inhibition in ANPmediated attenuation of MCP-1 expression, this action seems to be rather independent of NF-?B

Nina C. Weber; Signe B. Blumenthal; Thomas Hartung; Angelika M. Vollmar; Ra K. Kiemer

2003-01-01T23:59:59.000Z

359

Exposure to diesel exhaust up-regulates iNOS expression in ApoE knockout mice  

SciTech Connect

Traffic related particulate matter air pollution is a risk factor for cardiovascular events; however, the biological mechanisms are unclear. We hypothesize that diesel exhaust (DE) inhalation induces up-regulation of inducible nitric oxide synthase (iNOS), which is known to contribute to vascular dysfunction, progression of atherosclerosis and ultimately cardiovascular morbidity and mortality. Methods: ApoE knockout mice (30-week) were exposed to DE (at 200 {mu}g/m{sup 3} of particulate matter) or filtered-air (control) for 7 weeks (6 h/day, 5 days/week). iNOS expression in the blood vessels and heart was evaluated by immunohistochemistry and western blotting analysis. To examine iNOS activity, thoracic aortae were mounted in a wire myograph, and vasoconstriction stimulated by phenylephrine (PE) was measured with and without the presence of the specific inhibitor for iNOS (1400 W). NF-{kappa}B (p65) activity was examined by ELISA. The mRNA expression of iNOS and NF-{kappa}B (p65) was determined by real-time PCR. Results: DE exposure significantly enhanced iNOS expression in the thoracic aorta (4-fold) and heart (1.5 fold). DE exposure significantly attenuated PE-stimulated vasoconstriction by {approx} 20%, which was partly reversed by 1400 W. The mRNA expression of iNOS and NF-{kappa}B was significantly augmented after DE exposure. NF-{kappa}B activity was enhanced 2-fold after DE inhalation, and the augmented NF-{kappa}B activity was positively correlated with iNOS expression (R{sup 2} = 0.5998). Conclusions: We show that exposure to DE increases iNOS expression and activity possibly via NF-{kappa}B-mediated pathway. We suspect that DE exposure-caused up-regulation of iNOS contributes to vascular dysfunction and atherogenesis, which could ultimately lead to urban air pollution-associated cardiovascular morbidity and mortality. - Highlights: > Exposed ApoE knockout mice (30-week) to diesel exhaust (DE) for 7 weeks. > Examine iNOS expression and activity in the blood vessels and heart. > DE exposure enhanced iNOS protein and mRNA expression in the aorta and heart. > iNOS activity was also increased after DE exposure. > This up-regulation of iNOS may contribute to vascular dysfunction and atherogenesis.

Bai Ni [Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC (Canada); James Hogg Research Centre, Providence Heart and Lung Institute, St. Paul's Hospital, University of British Columbia, Vancouver, BC (Canada); Kido, Takashi [James Hogg Research Centre, Providence Heart and Lung Institute, St. Paul's Hospital, University of British Columbia, Vancouver, BC (Canada); Kavanagh, Terrance J.; Kaufman, Joel D.; Rosenfeld, Michael E. [Department of Occupational and Environmental Health, University of Washington, Seattle, WA (United States); Breemen, Cornelis van [Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC (Canada); Eeden, Stephan F. van, E-mail: Stephan.vanEeden@hli.ubc.ca [James Hogg Research Centre, Providence Heart and Lung Institute, St. Paul's Hospital, University of British Columbia, Vancouver, BC (Canada)

2011-09-01T23:59:59.000Z

360

Microsoft Word - Summary.doc  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Summary Summary To submit questions regarding this CMRR-NF SEIS, or to request a copy, please contact: AVAILABILITY OF THE FINAL SUPPLEMENTAL ENVIRONMENTAL IMPACT STATEMENT FOR THE NUCLEAR FACILITY PORTION OF THE CHEMISTRY AND METALLURGY RESEARCH BUILDING REPLACEMENT PROJECT AT LOS ALAMOS NATIONAL LABORATORY, LOS ALAMOS, NEW MEXICO (CMRR-NF SEIS) Printed with soy ink on recycled paper John Tegtmeier, EIS Document Manager Los Alamos Site Office National Nuclear Security Administration U.S. Department of Energy 3747 West Jemez Road Los Alamos, NM 87544 Telephone: 505-665-0113 Conceptual Drawing CMRR Facility Past Present Future Past Final Supplemental Environmental Impact Statement for the Nuclear Facility Portion of the Chemistry and Metallurgy Research Building Replacement Project

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Manufacturing Consumption of Energy 1994  

U.S. Energy Information Administration (EIA) Indexed Site

A9. A9. Total Inputs of Energy for Heat, Power, and Electricity Generation by Fuel Type, Census Region, and End Use, 1994: Part 1 (Estimates in Btu or Physical Units) See footnotes at end of table. Energy Information Administration/Manufacturing Consumption of Energy 1994 166 End-Use Categories (trillion Btu) kWh) (1000 bbl) (1000 bbl) cu ft) (1000 bbl) tons) (trillion Btu) Total (million Fuel Oil Diesel Fuel (billion LPG (1000 short Other Net Distillate Natural and Electricity Residual Fuel Oil and Gas Breeze) a b c Coal (excluding Coal Coke d RSE Row Factors Total United States RSE Column Factors: NF 0.5 1.3 1.4 0.8 1.2 1.2 NF TOTAL INPUTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16,515 778,335 70,111 26,107 5,962 25,949 54,143 5,828 2.7 Indirect Uses-Boiler Fuel . . . . . . . . . . . . . . . . . . . . . . . --

362

Low Dose Radiation Research Program: Universities  

NLE Websites -- All DOE Office Websites (Extended Search)

Universities Universities | Duke University | Loma Linda University | Northwestern University | University of Chicago | University of California Davis | Northwestern University University of Chicago University of California Davis Effects of Low Dose Irradiation on NF-κB Signaling Networks and Mitochondria Principal Investigator: Dr. Gayle Woloschak DOE Low Dose Research Program Projects Low dose-low dose rate irradiation leads to long term changes in numbers of mitochondria and mitochondrial genomes - Principal Investigator: Gayle Woloschak, Professor, Department of Radiation Oncology, Northwestern University, Chicago, IL, USA NF-κB-mediated pro-survival network in low dose radiation-induced adaptive protection - Principal Investigator: Jian Jian Li, Professor, Department of Radiation Oncology, University of California Davis, Davis,

363

http://www.ornl.gov/Procurement.PDF  

NLE Websites -- All DOE Office Websites (Extended Search)

93 93 1. All Grade 5 and Grade 8 fasteners of foreign origin which do not bear any manufacturer's headmarks: Grade 5 Grade 8 2. Grade 5 fasteners with the following manufacturers' headmarks: J Jinn Her (TW) KS Kosaka Kogyo (JP) J KS 3. Grade 8 fasteners with the following manufacturers' headmarks: A Asahi Mfg (JP) KS Kosaka Kogyo (JP) A KS NF RT NF Nippon Fasteners (JP) RT Takai Ltd (JP) H Hinomoto Metal (JP) FM Fastener Co (of JP) H FM J M MS KY M Minamida Sieybo (JP) KY Kyoei (JP) MS Minato Kogyo (JP) J Jinn Her (JP) E Hollow Infasco Co. (CA TW JP YU) Triangle (sizes greater than 1/2-in dia) UNY E Daiei (JP) UNY Unytite (JP) 4. Grade 8.2 fasteners with the following headmarks: KS Kosaka Kogyo (JP) KS 5. Grade A325 Fasteners (Bennett Denver Target only) with the following headmarks: A325 KS Kosaka Kogyo (JP)

364

ORNL/RASA-85/1 RESULTS OF THE II4OBILE GAMMA SCANNING ACTIVITIES IN NIAGARA FALLS, NEvl YORK AREA  

Office of Legacy Management (LM)

Nf7 n-q Nf7 n-q gz75 tLtY r 1 irl,r:'a :.a l: i , l : i l ',:lr.:'. itl:t i .,,::l ' i , t . . ORNL/RASA-85/1 RESULTS OF THE II4OBILE GAMMA SCANNING ACTIVITIES IN NIAGARA FALLS, NEvl YORK AREA Access to the information in this report is limited to thoss indicated on the distribution list and io Department ol Energy ancl Depsrtment of Energy Contractors This report was prepared as an account ol work sponsored by an agency of the United States Government. Neither the U nited StatesGovernment nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any informalion, apparatus, product, or process disclosed, or represents thal its use would not inf ringe

365

EIS-0350-S1: Draft Supplemental Environmental Impact Statement | Department  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Draft Supplemental Environmental Impact Statement Draft Supplemental Environmental Impact Statement EIS-0350-S1: Draft Supplemental Environmental Impact Statement Nuclear Facility Portion of the Chemistry and Metallurgy Research Building Replacement Project at Los Alamos National Laboratory, New Mexico National Nuclear Security Administration, a semiautonomous agency within DOE, proposes to complete the Chemistry and Metallurgy Research Building Replacement (CMRR) Project at Los Alamos National Laboratory (LANL) by constructing the nuclear facility portion (CMRR-NF) of the CMRR Project to provide the analytical chemistry and materials characterization capabilities currently or previously performed in the existing Chemistry and Metallurgy Research (CMR) Building. This CMRR-NF SEIS examines the potential environmental impacts associated with NNSA's proposed

366

Conceptual Drawing CMRR Facility Past  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Volume 1 Volume 1 Chapters 1 through 10 Appendices A through D To submit questions regarding this CMRR-NF SEIS, or to request a copy, please contact: AVAILABILITY OF THE FINAL SUPPLEMENTAL ENVIRONMENTAL IMPACT STATEMENT FOR THE NUCLEAR FACILITY PORTION OF THE CHEMISTRY AND METALLURGY RESEARCH BUILDING REPLACEMENT PROJECT AT LOS ALAMOS NATIONAL LABORATORY, LOS ALAMOS, NEW MEXICO (CMRR-NF SEIS) Printed with soy ink on recycled paper John Tegtmeier, EIS Document Manager Los Alamos Site Office National Nuclear Security Administration U.S. Department of Energy 3747 West Jemez Road Los Alamos, NM 87544 Telephone: 505-665-0113 Conceptual Drawing CMRR Facility Past Present Future Past Final Supplemental Environmental Impact Statement for the

367

Next-to-next-to-leading order soft gluon corrections in direct photon production.  

E-Print Network (OSTI)

) , (2.4) where F is the factorization scale, CA = Nc, and ?0 = (11CA ? 2nf )/3, with nf the number of quark flavors. We also define for use below T qq2 = ?(?0/4) + 2CF ln(p2T/s) and T qg 2 = ?(3/4)CF + (CF + CA) ln(p2T/s). Finally we write c fifj 1 = c... fifj 1 + T fifj 1 . For qq ? ?g we have c qq1 = CF [ ?3 2 ? ln ( p2T s )] ln ( 2F s ) + ?0 4 ln ( 2R s ) , (2.5) and T qq1 = CF [3/2+ln(p2T/s)] ln(p 2 T/s)?(?0/4) ln(2R/s)+c? qq 1 where c ?qq 1 is defined in Eq. (3.11) of Ref. [5]. For qg...

Kidonakis, Nikolaos; Owens, J F

368

Neutrino Factories  

SciTech Connect

Over the last decade there has been significant progress in developing the concepts and technologies needed to produce, capture and accelerate O(10{sup 21}) muons/year. This prepares the way for a Neutrino Factory (NF) in which high energy muons decay within the straight sections of a storage ring to produce a beam of neutrinos and anti-neutrinos. The NF concept was proposed in 1997 at a time when the discovery that the three known types of neutrino ({nu}{sub e}, {nu}{sub {mu}}, {nu}{sub {tau}}) can change their flavor as they propagate through space (neutrino oscillations) was providing a first glimpse of physics beyond the Standard Model. This development prepares the way for a new type of neutrino source: a Neutrino Factory. This article reviews the motivation, design and R&D for a Neutrino Factory.

Geer, Steve; /Fermilab

2010-01-01T23:59:59.000Z

369

Near the sill of the conformal window: gauge theories with fermions in two-index representations  

E-Print Network (OSTI)

We apply Schroedinger functional methods to two gauge theories with fermions in two-index representations: the SU(3) theory with Nf=2 adjoint fermions, and the SU(4) theory with Nf=6 fermions in the two-index antisymmetric representation. Each theory is believed to lie near the bottom of the conformal window for its respective representation. In the SU(3) theory we find a small beta function in strong coupling but we cannot confirm or rule out an infrared fixed point. In the SU(4) theory we find a hint of walking - a beta function that approaches the axis and then turns away from it. In both theories the mass anomalous dimension remains small even at the strongest couplings, much like the theories with fermions in the two-index symmetric representation investigated earlier.

Thomas DeGrand; Yigal Shamir; Benjamin Svetitsky

2013-07-09T23:59:59.000Z

370

The electric dipole moment of the nucleon from simulations at imaginary vacuum angle theta  

E-Print Network (OSTI)

We compute the electric dipole moment of proton and neutron from lattice QCD simulations with N_f=2 flavors of dynamical quarks at imaginary vacuum angle theta. The calculation proceeds via the CP odd form factor F_3. A novel feature of our calculation is that we use partially twisted boundary conditions to extract F_3 at zero momentum transfer. As a byproduct, we test the QCD vacuum at nonvanishing theta.

R. Horsley; T. Izubuchi; Y. Nakamura; D. Pleiter; P. E. L. Rakow; G. Schierholz; J. Zanotti

2008-08-10T23:59:59.000Z

371

Design of Accumulator and Compressor Rings for the Project-X Based Proton Driver  

Science Conference Proceedings (OSTI)

A Muon Collider (MC) and a Neutrino Factory (NF) - which may be considered as a step towards a MC - both require a high-power ({approx}4 MW) proton driver providing short (compressor ring can be nearly isochronous in order to limit the required RF voltage and reduce the dispersion contribution to the beam size. In the present report we consider ring lattice designs which achieve these goals.

Alexahin, Y.; Neuffer, D.; /Fermilab

2012-05-01T23:59:59.000Z

372

Quark helicity flip generalized parton distributions from two-flavor lattice QCD  

E-Print Network (OSTI)

We present an initiatory study of quark helicity flip generalized parton distributions (GPDs) in n_f=2 lattice QCD, based on clover-improved Wilson fermions for a large number of coupling constants and pion masses. Quark helicity flip GPDs yield essential information on the transverse spin structure of the nucleon. In this work, we show first results on their lowest moments and dipole masses and study the corresponding chiral and continuum extrapolations.

M. Gockeler; Ph. Hagler; R. Horsley; D. Pleiter; P. E. L. Rakow; A. Schafer; G. Schierholz; J. M. Zanotti

2005-07-01T23:59:59.000Z

373

Biochem. J. (2008) 411, 531541 (Printed in Great Britain) doi:10.1042/BJ20071534 531 Endosomal NADPH oxidase regulates c-Src activation following  

E-Print Network (OSTI)

and the Center for Gene Therapy, The College of Medicine, University of Iowa, Iowa City, IA 52242, U.S.A. c-Src has been shown to activate NF-B (nuclear factor B) following H/R (hypoxia/reoxygenation) by acting participate in the initial redox activation of c-Src following H/R. In summary, our results suggest that Rac1

Engelhardt, John F.

374

ANHANG A: FORSCHUNG Tabelle A1: Sonderforschungsbereiche  

E-Print Network (OSTI)

. HF 1 5 6 Chemie MA NF 0 2 3 COMMAS MSc 29 22 24 28 Computational Physics BSc 5 11 6 3 Deutsch LA Gym.o. Diplom 226 151 96 Germanistik/Deutsch HF 184 152 121 Politikwiss./Sozialwiss. HF 117 95 37 Chemie Diplom. Umweltingenierwissen- schaften 0 0 3 Chemie 7 6 4 Geo- und Biowissenschaften 2 2 5 Informatik, Elektrotechnik u

Möbius, Bernd

375

Static-light mesons on a dynamical anisotropic lattice  

E-Print Network (OSTI)

We present results for the spectrum of static-light mesons from Nf=2 lattice QCD. These results were obtained using all-to-all light quark propagators on an anisotropic lattice, yielding an improved signal resolution when compared to more conventional lattice techniques. In particular, we consider the inversion of orbitally-excited multiplets with respect to the `standard ordering', which has been predicted by some quark models.

Justin Foley; Alan O Cais; Mike Peardon; Sinead M Ryan

2006-10-09T23:59:59.000Z

376

An Introductory Textbook on Cyber-Physical Systems Edward A. Lee  

E-Print Network (OSTI)

Webs) and #0720841 (CSR- CPS)), the U. S. Army Research Office (ARO #W911NF- 07-2-0019), the U. S. Air Force Office of Scientific Research (MURI #FA9550-06-0312 and AF-TRUST #FA9550-06-1- 0244), the Air Force Research Lab (AFRL ACM 1-58113-000-0/00/0010 ...$10.00. to write books (like the one presented here), search for infor

Seshia, Sanjit A.

377

NUMERICAL ANALYSIS OF FLOW FIELDS GENERATED BY ACCELERATING FLAMES  

E-Print Network (OSTI)

TR=D60*1 pf'o/nf>o/I GF-I '+UfO*.2/0f C. *2/2. ' C-----A(CTC SC=INITIAL STEP ~IZE C A"UFO=SPtC VOL "ATIC FCI' CCNST PRE=CFI". ~1 $ UPCCl,I,::UFO',O) EPC(I,I'=EP(M,O' $ PPC(I, II=

Kurylo, J.

2011-01-01T23:59:59.000Z

378

SOME ANALYTIC MODELS OF PASSIVE SOLAR BUILDING PERFORMANCE: A THEORETICAL APPROACH TO THE DESIGN OF ENERGY-CONSERVING BUILDINGS  

E-Print Network (OSTI)

N f Cf A A P A w A U wo C w Ufo Cf A G A f A p U NfNw q ~= CA A = A f G (1 _ N f ) N R Ufo C f A F = A R N N N f R A Q == A f A N h f A (a s) R N A Ufo a = A f - + C - N f R Table

Goldstein, David Baird

2011-01-01T23:59:59.000Z

379

EIS-0350-S1: Supplemental Environmental Impact Statement for the Nuclear Facility Portion of the Chemistry and Metallurgy Research Building Replacement Project at Los Alamos National Laboratory, New Mexico  

Energy.gov (U.S. Department of Energy (DOE))

This Supplemental EIS evaluates the completion of the Chemistry and Metallurgy Research Building Replacement (CMRR) Project, which consists of constructing the nuclear facility portion (CMRR-NF) at Los Alamos National Laboratory (LANL). The CMRR Project provides the analytical chemistry and materials characterization capabilities currently or previously performed in the existing Chemistry and Metallurgy Research (CMR) Building. Because of recent detailed site geotechnical investigations, certain aspects of the CMRR-NR project have changed resulting in change to the environmental impacts.

380

Newsfront 13-19 August 2007, Issue 29  

E-Print Network (OSTI)

Kathmandu l 13-19 August, 2007 l # 29 l Price Rs. 25 l www.newsfront.com.np Inside Maoists targeting media - page 2 Rayamajhi report: Nepali standard of investigation - page 5 nf special correspondent Prime Minister GP Koirala faces a... that he also accompa- nied the former US president, Jimmy Carter to Shivapuri national park. Nepal offers a great opportunity for nature conservation and studies. Like the extinct species of birds and animals, committed conservationists like Kazi are rare...

Ghimire, Yubaraj

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Design of Accumulator and Compressor Rings for the Project-X Based Proton Driver  

SciTech Connect

A Muon Collider (MC) and a Neutrino Factory (NF) - which may be considered as a step towards a MC - both require a high-power ({approx}4 MW) proton driver providing short (<1 m r.m.s. length) bunches for muon production. However, the driver repetition rates required for these two machines are different: {approx}15 Hz for MC and {approx}60 Hz for NF. This difference suggests employing two separate rings: one for accumulation of the proton beam from the Project-X linac in a few (e.g. 4) long bunches, the other for bunch compression - one by one for NF or all at a time for MC with simultaneous delivery to the target. The lattice requirements for these two rings are different: the momentum compaction factor in the accumulator ring should be large (and possibly negative) to avoid the microwave instability, while the compressor ring can be nearly isochronous in order to limit the required RF voltage and reduce the dispersion contribution to the beam size. In the present report we consider ring lattice designs which achieve these goals.

Alexahin, Y.; Neuffer, D.; /Fermilab

2012-05-01T23:59:59.000Z

382

Achieving very low mercury levels in refinery wastewater by membrane filtration.  

Science Conference Proceedings (OSTI)

Microfiltration (MF), ultrafiltration (UF), nanofiltration (NF) and reverse osmosis (RO) membranes were evaluated for their ability to achieve the world's most stringent Hg discharge criterion (oil refinery's wastewater. The membrane processes were operated at three different pressures to demonstrate the potential for each membrane technology to achieve the targeted effluent mercury concentrations. The presence of mercury in the particulate form in the refinery wastewater makes the use of MF and UF membrane technologies more attractive in achieving very low mercury levels in the treated wastewater. Both NF and RO were also able to meet the target mercury concentration at lower operating pressures (20.7 bar). However, higher operating pressures ({ge}34.5 bar) had a significant effect on NF and RO flux and fouling rates, as well as on permeate quality. SEM images of the membranes showed that pore blockage and narrowing were the dominant fouling mechanisms for the MF membrane while surface coverage was the dominant fouling mechanism for the other membranes. The correlation between mercury concentration and particle size distribution was also investigated to understand mercury removal mechanisms by membrane filtration. The mean particle diameter decreased with filtration from 1.1 {+-} 0.0 {micro}m to 0.74 {+-} 0.2 {micro}m after UF.

Urgun Demirtas, M.; Benda, P.; Gillenwater, P. S.; Negri, M. C.; Xiong, H.; Snyder, S. W. (Center for Nanoscale Materials); ( ES)

2012-05-15T23:59:59.000Z

383

Large N Volume Independence and an Emergent Fermionic Symmetry  

E-Print Network (OSTI)

Large-N volume independence in circle-compactified QCD with N_f \\geq 1 adjoint Weyl fermions implies the absence of any phase transitions as the radius is dialed to arbitrarily small values. This class of theories are believed to possess a Hagedorn density of hadronic states. It turns out that these properties are in apparent tension with each other, because a Hagedorn density of states typically implies a phase transition at some finite radius. This tension is resolved if there are degeneracies between the spectra of bosonic and fermionic states, as happens in the N_f=1 supersymmetric case. Resolution of the tension for N_f>1 then suggests the emergence of a fermionic symmetry at large N, where there is no supersymmetry. We can escape the Coleman-Mandula theorem since the N=\\infty theory is free, with a trivial S-matrix. We show an example of such a spectral degeneracy in a non-supersymmetric toy example which has a Hagedorn spectrum.

Basar, Gokce; Dorigoni, Daniele; Unsal, Mithat

2013-01-01T23:59:59.000Z

384

Induction of nuclear factor kB after low-dose ionizing radiation involves a reactive oxygen intermediate signaling pathway  

Science Conference Proceedings (OSTI)

Reactive oxygen intermediates (ROIs) have been found to be the messengers in the activation of the kB transcription regulator in mitogen- or cytokine-stimulated cells, operating in conjunction with or independently of various other mechanisms; these include Ca{sup ++}-dependent and PKC-dependent cytoplasmic signaling pathways. We have recently reported that low-dose ionizing radiation induces NF-kB in human lymphoblastoid 244B cells. Since ionizing radiation generates free radicals in cells, we have investigated whether the ROIs generated by ionizing radiation induce NF-kB activity, and also whether they do so by a similar mechanism as in cells treated with PMA or H{sub 2}O{sub 2}. The results not only confirm a previous observation from our laboratory that low-dose ionizing radiation (0.1-2.0 Gy) activates kB transcription factor transiently with a maximal induction at 0.5 Gy exposure, but also demonstrate mechanistically that the activation of NF-kB by low-dose ionizing radiation can be inhibited considerably by the antioxidant N-acetyl-L-cysteine, indicating that at least the major part of the activation process is mediated by ROIs. These findings support the idea that ROIs can regulate the kB elements which in turn can serve as response elements for oxidant stress. 37 refs., 4 figs., 1 tab.

Mohan, N.; Meltz, M.L. [Univ. of Texas Health Science Center, San Antonio, TX (United States)

1994-10-01T23:59:59.000Z

385

Ionizing radiation induces IL-6-production by human fibroblasts involving activation of nuclear factor-. kappa. B  

Science Conference Proceedings (OSTI)

The authors report that human lung fibroblasts respond to X-ray treatment with release of interleukin (IL) -6. Synthesis of IL-6 upon ionizing radiation is preceded by an increase of IL-6 transcript levels resulting from transcriptional activation of the IL-6 gene. Analysis of deleted fragments of the IL-6 promoter revealed that transcriptional induction of the IL-6 promoter is due to enhanced binding activity of the transcription factor NF-kB. Although AP-1 does not participate in the rapid induction of the IL-6 promoter its binding activity is also enhanced upon XRT. In contrast to binding kinetics observed with NF-kB, AP-1 binding upon XRT. In contrast to binding kinetics observed with NF-kB- and the AP-1 recognition sequence, conferred inducibility by XRT to a heterologous promoter, with reporter gene activity being maximal 24 hours or 48 hours upon XRT, respectively. Sequential activation of two distinct transcription factors might thus contribute to synchronize transcriptional activation of different genes participating in the X-ray response.

Brach, M.A.; Gruss, H.J.; Kaisho, Tsuneyasu; Asano, Yoshinobu; Vos, Sven de; Mertelsmann, R.; Hirano, Toshio; Herrmann, F. (Univ. of Freiburg (Germany) Osaka Univ. (Japan))

1992-02-26T23:59:59.000Z

386

Nepali Aawaz Volume 1, Issue 14, 10 May 2006  

E-Print Network (OSTI)

O{Psf] sfo{qmddf ;+3if{ Aof08sf ;Gtf]if kl/of/, ;Gtf]if u'?, ;'lbk alzi7, ;'/h / u0f]zn] nfO{e sG;6{ k|:t't u/]sf lyP . To:t} g]kfnsf rrL{t o'jf ufos k|sfz kf}8]n, ;GWof u|'k, td' af}4 ;]jf ;dfhssf snfsf/x?n] uLt g[To k|:t't u/]sf lyP . em08} $ 306f... 'ofPsf] lyof] . pgn] 8]9 jif{cl3 cd]l/sL gful/s;Fu} ljx] u/]/ pt} 3/hd ul;s]sLl5g . ;ft dlxgf cl3 cd]l/sf k'u]sL gflosf k'hf rGb afN6Ldf]/sf] Ps Aofkfl/s s]Gb|df sfd ub}{ df]8\\ln\\ lt/ nfUg] tof/Ldf l5g . cf7 jif{ cl3 k'u]sf nf]s ufos k|]d/fhf dxtn] cd...

Shrestha, Kashish Das

387

The Polyakov loop and the hadron resonance gas model  

E-Print Network (OSTI)

The Polyakov loop has been used repeatedly as an order parameter in the deconfinement phase transition in QCD. We argue that, in the confined phase, its expectation value can be represented in terms of hadronic states, similarly to the hadron resonance gas model for the pressure. Specifically, L(T) \\approx 1/2\\sum_\\alpha g_\\alpha e^(-\\Delta_\\alpha/T), where g_\\alpha are the degeneracies and \\Delta_\\alpha are the masses of hadrons with exactly one heavy quark (the mass of the heavy quark itself being subtracted). We show that this approximate sum rule gives a fair description of available lattice data with N_f=2+1 at low temperatures by using the spectrum of hadrons containing one charmed quark, and the \\bar{MS}-scheme charmed quark mass. A direct fit to this latter quantity yields a close value, m_c=1280_{-44}^{+29}MeV. The lattice data are well reproduced by a simplified version of this formula, L(T)= N_f(2N_f+3)e^(-\\Delta/T), for T < 200 MeV and Delta=913(2)MeV. We argue that this number should be Delta ...

Megias, E; Salcedo, L L

2012-01-01T23:59:59.000Z

388

Low Dose Radiation Research Program: Jian Jian Li  

NLE Websites -- All DOE Office Websites (Extended Search)

Jian Jian Li Jian Jian Li School of Health Sciences, Purdue University Newly Funded Projects Regulation of NF-kB and Mn SOD in Low Dose Radiation-Induced Adaptive Responses in Mouse and Human Skin Cells, abstract, description. Technical Abstracts 2006 Workshops: NF-kB Mediated Signaling Network in Low Dose X-Ray Induced Adaptive Protection on Mouse and Human Skin Epithelial Cells Ahmed, K.M., Fan, M., Spitz, and Li, J.J. 2005 Workshops: Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Ionizing Radiation: Induction of NF-κB, MnSOD, 14-3-3ζ and Cyclin B1. Li, J.J., Ahmed, K.M., Fan, M., Dong, S., Spitz, D.R., and Yu, C.-R. 2003 Workshops: Gene Expression Profiles of Human Skin Keratinocytes Exposed to Acute and Chronic Ionizing Radiation Li, J.J., Ozeki, M., Wang, T., Tamae, D., Nelson, D., Wyrobek, A., and

389

Potential Impacts of Desalination Concentrate on Salinity of Irrigation Water: A Case Study in the El Paso Valley  

E-Print Network (OSTI)

Winter returnflow has not been fully utilized for crop irrigation in the El Paso Valley. There are, however, emerging interests in utilizing it for urban water supply through desalting. This study examined the potential impact of concentrate discharge on salinity, sodicity, and ionic composition of irrigation water supply, using historical or published records. The analyses performed consisted of the estimate of riverflow rates on river water quality, a review of concentrate and permeate quality from nanofiltration (NF) and reverse osmosis (RO), and the impacts of dilution or blending on water quality. Riverflow and quality data from the U.S. Section, International Boundary and Water Commission (US-IBWC) were examined first. This analysis has shown that salinity and ionic composition of riverflow can be described by a simple power function as related to the momentary riverflow rate when water samples were taken for chemical analyses. This method provides more accurate estimates of monthly salinity than the use of monthly average flow which has a high degree of variation. In addition, this approximation technique allows for the estimation of river salinity and ionic compositions at any riverflow rates of interest. A review of published articles on NF processes indicates that there are essentially two types of membranes: one has a low rejection rate for Na and Cl, and the other has a high rejection rate. If the objective is to minimize Na and Cl ions while maximizing Ca and Mg concentrations in the concentrate, the first type is preferred. However, the sodium adsorption ratio (SAR) of concentrate from the first type of NF membrane is also influenced by feed water quality. Typically, the SAR of the concentrate does not change appreciably in water that is rich in SO4, as the rejection rate of SO4 is high, and SO4 ions remain in the concentrate along with accompanying cations. The SAR of the concentrate is not necessarily lower than that of feed water, due to the salt concentration effect on SAR. The SAR value which directly impacts the cation exchange reaction in soils decreases with dilution, but increases due to the increased formation of sulfate-divalent cation ion-pairs. Sodicity of the concentrate from the second type is higher than the sodicity of feed water or that of the concentrate from the first type, and approaches the concentrate composition from a RO process. The most significant changes that take place in the concentrate composition from the first type are an increase in TDS and divalent cations and anions, whereas sodicity and chloride concentrations remain more or less the same as those of feed water. Permeate from the first type of NF membrane is likely to be higher in Na, Cl, and TDS than from the second type. These elevated salt levels limit the opportunity for blending with the river water, which has elevated salinity and SO4 concentrations, especially at a low riverflow of 5 Mm3/mo or less. Sodicity and the concentrations of Na and Cl in the permeate could also exceed the unofficial water quality guidelines for irrigating urban landscape. If the RO process or the second type of NF membrane is used, the permeate can be blended with river water at nearly a 1:1 ratio. This means that a lesser quantity of water needs to be treated when a RO process is used. If river water high in Na and Cl concentrations is used for blending, the salt load of the concentrate from the NF process can actually be greater than that from the RO process, because of the limited blending possibility. If the NF option is to be retained, a NF membrane with some rejection of Cl ions may be warranted, unless blending water low in Cl is available at or near the site. Assuming that flow and salinity monitoring data at the Courchesne Bridge are realistic, the disposal of NF concentrate from 5 and 10 MGD membrane processes at a riverflow rate of 5 Mm3/mo may increase salinity of riverwater by around 7 and 16%, respectively, over the existing salinity. This estimate is for a NF membrane with a low

Miyamoto, S.

2008-05-01T23:59:59.000Z

390

Effects of 4-phenylbutyric acid on the process and development of diabetic nephropathy induced in rats by streptozotocin: Regulation of endoplasmic reticulum stress-oxidative activation  

Science Conference Proceedings (OSTI)

Oxidative stress may contribute to the pathogenesis of diabetic nephropathy (DN), although the precise regulatory mechanism is still unclear. Recent reports have shown that chemical molecular chaperone 4-phenylbutyric acid (4-PBA) can suppress oxidative stress by attenuating endoplasmic reticulum (ER) stress. We therefore hypothesized that 4-PBA could provide renoprotection through the suppression of oxidative stress in DN rats. Male Sprague-Dawley (SD) rats were randomly divided into three groups: a normal control (NC) group, a streptozotocin (STZ)-induced DN model group, and a DN plus 4-PBA (1 g/kg) treatment group. At the end of 4, 8, and 12 weeks, hydroxyproline content, NADPH oxidase activity and the expression of phosphorylation of inositol-requiring enzyme-1{alpha} (p-IRE1{alpha}), p47phox, nitrotyrosine (NT) and NF-E2-related factor 2 (Nrf2) in the kidneys of all rats were determined; malondialdehyde (MDA) levels and superoxide dismutase (SOD) activity in serum and urine were also detected; renal nuclear factor {kappa}B (NF-{kappa}B) activity in all of the rats was examined at the end of 12 weeks. Compared with the NC group, the DN rats showed a significant increase in hydroxyproline content, NADPH oxidase activity, NF-{kappa}B activity, the expression of p-IRE1{alpha}, p47phox, NT and Nrf2 in renal tissue; markedly, MDA levels were higher and SOD activity was lower in serum and urine of DN rats than in NC rats for the indicated time. These alterations were inhibited by the administration of 4-PBA. These findings first demonstrated that treatment with 4-PBA significantly inhibits the process and development of diabetic nephropathy in rats through the regulation of ER stress-oxidative activation.

Luo Zhifeng [Institute of Nephrology of Chongqing and Department of Nephrology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037 (China); Feng Bing, E-mail: fxb12@yahoo.com.c [Institute of Nephrology of Chongqing and Department of Nephrology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037 (China); Mu Jiao; Qi Wei; Zeng Wei; Guo Yanhong; Pang Qi; Ye Zilin; Liu Li; Yuan Fahuan [Institute of Nephrology of Chongqing and Department of Nephrology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037 (China)

2010-07-15T23:59:59.000Z

391

In vivo footprinting of the human [alpha]-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction  

SciTech Connect

A major regulatory element required for expression of the human [alpha]-globin genes is located 40 kb upstream of the embryonic [zeta]-globin gene. To understand how this and other locus control region (LCR) elements contribute to high-level expression in erythroid cells, we have performed high-resolution, in vivo dimethyl sulfate footprinting. In addition, we have modified the dimethyl sulfate-based ligation-mediated polymerase chain reaction in vivo footprinting procedure to permit the assessment of interactions at guanine and adenine residues, rather than guanines alone. In vivo footprinting of the human [alpha]-LCR element carried on chromosome 16 in a mouse erythroleukemia cell environment revealed protein occupancy at GATA-1, AP-1/NF-E2, and CACC/GGTGG motifs, specific differences compared with in vitro protein binding, and distinct changes in one region upon dimethyl sulfoxide-induced cellular maturation. No protein contacts were detected in nonexpressing hepatoma cells. In addition, we have demonstrated that two AP-1 motifs in the [alpha]-LCR element which are occupied in vivo bind purified mouse NF-E2 protein in vitro. Our data suggest that three proteins, GATA-1, NF-E2, and unknown CACC/GGTGG factors, are minimally required as DNA-binding proteins for the function of LCR-like elements. The juxtaposition and interaction of these factors with each other, and with accessory proteins not directly in contact with DNA, are likely to account for the relative position independence of the upstream globin regulatory elements. 39 refs., 6 figs.

Strauss, E.C.; Andrews, N.C.; Orkin, S.H.; Higgs, D.R. (Howard Hughes Medical Institute, Boston, MA (United States))

1992-05-01T23:59:59.000Z

392

ABM11 parton distributions and benchmarks  

E-Print Network (OSTI)

We present a determination of the nucleon parton distribution functions (PDFs) and of the strong coupling constant $\\alpha_s$ at next-to-next-to-leading order (NNLO) in QCD based on the world data for deep-inelastic scattering and the fixed-target data for the Drell-Yan process. The analysis is performed in the fixed-flavor number scheme for $n_f=3,4,5$ and uses the $\\bar{MS}$ scheme for $\\alpha_s$ and the heavy quark masses. The fit results are compared with other PDFs and used to compute the benchmark cross sections at hadron colliders to the NNLO accuracy.

S. Alekhin; J. Bluemlein; S. -O. Moch

2012-08-07T23:59:59.000Z

393

Table A18. Quantity of Electricity Sold to Utility and Nonutility Purchasers  

U.S. Energy Information Administration (EIA) Indexed Site

8. Quantity of Electricity Sold to Utility and Nonutility Purchasers" 8. Quantity of Electricity Sold to Utility and Nonutility Purchasers" " by Census Region, Industry Group, and Selected Industries, 1991" " (Estimates in Million Kilowatthours)" " "," "," "," "," ","RSE" "SIC"," "," ","Utility ","Nonutility","Row" "Code(a)","Industry Groups and Industry","Total Sold","Purchaser(b)","Purchaser(c)","Factors" ,,"Total United States" ,"RSE Column Factors:",0.9,1,1 , 20,"Food and Kindred Products",988,940,48,16.2 2011," Meat Packing Plants",0,0,0,"NF"

394

ESS 2012 Peer Review - Novel High Energy Density Dielectrics for Scalable Capacitor Needs - Geoff Brennecka, SNL  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Novel High Energy Density Novel High Energy Density Dielectrics for Scalable Capacitor Needs 27 September 2012 Geoff Brennecka The author gratefully acknowledges the support of Dr. Imre Gyuk and the Department of Energy's Office of Electricity Delivery and Energy Reliability. 400nF 2000V Project  Currently-available capacitor options force undesired choices:  (power, capacitance) vs. reliability  performance vs. (temperature, voltage) stability  Capacitors are often not deployed where they could be beneficial, or are deployed and fail (or are severely derated)  Stationary storage and related applications can realize significant value via improved capacitor performance and reliability  Improve reliability and efficiency of high temperature power electronics

395

Cytotoxicological Response to Engineered Nanomaterials: A Pathway-Driven Process  

E-Print Network (OSTI)

Nanoparticles, while included in a growing number of consumer products, may pose risks to human health due to heavy metal leaching and/or the production of reactive oxygen species following exposures. Subcellular mechanisms of action triggered as a result of exposure to various nanoparticles are still largely unexplored. In this work, an effort to elucidate such toxicological parameters was accomplished by evaluating oxidative stress generation, changes in gene and protein expression, and cell cycle status after low-dose exposures to a variety of metal and carbon-based nanomaterials in primary human dermal cells. Additionally, mitigation of nanoparticle toxicity via microencapsulation was investigated to assess the feasibility of utilizing nanomaterials in dermally implantable biosensor applications. Cellular immune and inflammatory processes were measured via qPCR and immunoblotting, which revealed gene and protein expression modulation along the NF-kappaB pathway after a variety of nanoparticle exposures. The role of immunoregulatory transcription factor NF-kappaB was examined in an oxidative stress context in cells exposed to a panel of nanoparticles, whereby glutathione conversion and modulation of oxidative stress proteins in normal and NF-kappaB knockdown human dermal fibroblasts were monitored. Results revealed decreased antioxidant response and corresponding increased levels of oxidative stress and cell death in exposed normal cells, compared to NF-kappaB incompetent cells. However, reactive oxygen species production was not an absolute precursor to DNA damage, which was measured by the comet assay, gamma-H2AX expression, and flow cytometry. Protein analysis revealed that map kinase p38, rather than p53, was involved in the halting of the cell cycle in S-phase after ZnO exposures, which caused DNA double strand breaks. Microencapsulation of fluorescent quantum dot nanoparticles, specifically, was utilized as a method to improve system functionality and surrounding cellular viability for the purpose of a dermal analyte detection assay. In vitro results indicated a functional localization of nanoparticles, as well as cessation of cellular uptake. Subsequently, cellular metabolism was unaffected over the range of time and concentrations tested in comparison to unencapsulated quantum dot treatments, indicating the usefulness of this technique in developing nanoparticle-driven biomedical applications.

Romoser, Amelia Antonia

2012-05-01T23:59:59.000Z

396

The Lattice Free Energy with Overlap Fermions: A Two-Loop Result  

E-Print Network (OSTI)

We calculate the 2-loop partition function of QCD on the lattice, using the Wilson formulation for gluons and the overlap-Dirac operator for fermions. Direct by-products of our result are the 2-loop free energy and average plaquette. Our calculation serves also as a prototype for further higher loop calculations in the overlap formalism. We present our results as a function of a free parameter $M_0$ entering the overlap action; the dependence on the number of colors $N$ and fermionic flavors $N_f$ is shown explicitly.

A. Athenodorou; H. Panagopoulos

2004-08-12T23:59:59.000Z

397

Newsfront 3-9 March 2008, Issue 56  

E-Print Network (OSTI)

worldwide inflation. Even if domestic fuel prices are to increase, it must be well managed and gradual. Another instance of rampant inefficiency and malpractice behavior lies in the electricity sector. At a broad level, two major issues persist - absence... Kathmandu l 3-9 March, 2008 l # 56 l Price Rs. 25 www.newsfront.com.np Ph:- Shop 5011685, Factory: 5555459 nf correspondent The three minor constituents of the ruling alliance have come out openly against the 'big-brother' attitude of the top...

Ghimire, Yubaraj

398

Making the most of Taylor expansion and imaginary chemical potential  

E-Print Network (OSTI)

We present preliminary results for the curvature of the pseudocritical line and susceptibilities in Nf = 2 + 1 flavor QCD. The computations are carried out on lattice sizes of 16x16x16x4, at matching parameters of early work of the Bielefeld group. Emphasis is placed on the control of systematic errors, by cross-validating results obtained by use of the Taylor expansion and measurements at imaginary chemical potential. To this end, we generalize the magnetic equation of state to the analysis of the number density, and we extend it to imaginary values of the chemical potential.

E. Laermann; F. Meyer; M. P. Lombardo

2013-04-11T23:59:59.000Z

399

Thermal Performance of Poly Alpha Olefin Nanofluid with Spherical and Non-spherical Nanoparticles  

E-Print Network (OSTI)

Research on nanofluids has been undertaken for several years because of the reported enhancements of thermal properties such as thermal conductivity and enhanced heat transfer performance in laminar flow. Nanofluid is the fluid where nanoparticles are dispersed in a base fluid. Thermal conductivity and viscosity are considered to be the most prominent factors in the efficient use of nanofluids. A change in thermal conductivity and viscosity also changes the convective heat transfer coefficient. Nanoparticles can be metallic or non-metallic and also can have different shapes. In this study, Poly-Alpha-Olefin (PAO) has been used as a base fluid with Alumina (Al2O3) nanoparticles. Poly-Alpha-Olefin is commonly used for engine lubrication in military applications and cooling in electronic and industrial devices. Several nanofluid samples were made by METSS Corp. in Ohio, USA using different dispersants, different base fluids and different morphology of alumina nanoparticles. The mass fraction of nanoparticles is from 2.5 to 20 percent. The thermal properties of each sample such as thermal conductivity and viscosity have been measured. Thermal conductivity of nanofluids and pure base fluids were both measured and the thermal conductivity enhancement has been calculated. Also, the heat transfer coefficient has been determined for laminar flow under constant heat flux conditions. Results indicate that all the tested nanofluids and base fluid samples show a Newtonian behavior. Among the nanofluid samples, NF-048, which contains non-spherical Alumina nanoparticles exhibits the greatest thermal conductivity enhancement when compared to pure PAO. Heat transfer tests were conducted with pure PAO and NF-048, and an enhancement in convective heat transfer coefficient was observed. The thermal conductivity of NF-048 increases with temperature, which is consistent with heat transfer results. Furthermore, the percentage enhancement in convective heat transfer coefficient was shown to increase non-linearly with the axial distance in the heat transfer section. NF-048 exhibits a lower Re (Reynolds number)*Ra (Rayleigh number) than pure PAO under laminar flow constant heat flux conditions indicating that nanoparticle morphology and composition are the two main factors responsible for convective heat transfer enhancement at low Reynolds number.

Park, Chan Hyun

2011-05-01T23:59:59.000Z

400

Application of Domain Decomposition to the Evaluation of Fermion Determinant Ratios  

E-Print Network (OSTI)

We analyze the fluctuations in the case of mass reweighting for N_f=2 Wilson fermions. We use a domain decomposition factorization of the fermion determinant. Ratios of determinants are estimated stochastically. We study the stochastic and the ensemble fluctuations as a function of the volume V and the mass shift Delta m. With our result it is possible to estimate the cost and the effectiveness of mass reweighting. In addition we introduce a stochastic estimation for the one flavor case without using the square root.

Jacob Finkenrath; Francesco Knechtli; Bjrn Leder

2012-11-06T23:59:59.000Z

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Communicating oscillatory networks: Frequency Domain Analysis  

E-Print Network (OSTI)

-deterministic models and used the presented techni- que of frequency domain analysis to investigate the differ- ences. The quasi-deterministic models are constructed from exactly the same reaction scheme and kinetic para- meters, however the kinetic functions... significant role in our findings. Note in particular from Additional file 1 Table S4 that the two species that directly perturb the cell cycle (namely p53a and NF-#1;Bn) have low stochasticity, so any noise inherent in their respective net- works does...

Ihekwaba, Adaoha E C; Sedwards, Sean

2011-12-22T23:59:59.000Z

402

Dynamical SUSY Breaking and the Beta-Deformation  

E-Print Network (OSTI)

We study supersymmetry breaking metastable vacua arising from beta deformed quiver gauge theories. The relation between the bounds on metastability and the deformation are discussed. Metastable supersymmetry breaking vacua are found in the IR of beta deformed cascading quivers with vector-like field content. Furthermore the limiting case of massive Nf=Nc SQCD appears in the IR of gauge theories with chiral-like field content. We comment on the field theory origin of the deformation and on possible applications in AdS/CFT.

Amariti, A

2010-01-01T23:59:59.000Z

403

Nepali Aawaz Volume 1, Issue 9, 24 January - 7 February 2006  

E-Print Network (OSTI)

Psf] lyof] . :yndfu{jf6 klg ToxfF;Dd ;]gf k'Ug ;Sof] . t/ ;]gfn] Tof] hf]lvd df]Ng grfx]sf] b]lvof] . j? Pp6f ;}lgs x]lnsK6/ cfO sfo{qmd :yn j/k/ / ;8s cj?4 u/]sf 7fpFdf rf/kfFr kmGsf nufof] . e]nf ePsf ;j{;fwf/0f cft+lst eO efUg yfn] . t/ ;]gfn] xjf...

Shrestha, Kashish Das

404

Thermodynamics using p4-improved staggered fermion action on QCDOC  

E-Print Network (OSTI)

We present an exploratory study of the thermodynamics of $N_f=3$ QCD with an improved staggered fermions using the QCDOC supercomputer. We use a p4 action with MILC-style smeared links (Fat 7). Some details of the implementation of the p4 action on QCDOC are discussed and performance benchmarks are given. We show preliminary results for the quark mass dependence of the pseudo-critical temperature $T_c$ from several lattice volumes . We also make a comparison between p4fat7 and the old p4 action.

Chulwoo Jung

2005-10-05T23:59:59.000Z

405

Characterization of a heat resistant beta-glucosidase as a new reporter in cells and mice  

E-Print Network (OSTI)

, bladder and small intestinal samples from Ahcre/R26(SYNbglA)R mice induced with ?- napthoflavone 1-6 weeks previously were fixed in various fixatives for 1-6 h, processed through an ascending series of ethanols, xylene and into paraffin wax at 65C... - neal injections of 80 mg/kg ?-napthoflavone (?NF; Sigma) dissolved in corn oil (8 mg/mL) at the frequencies stated and controls received either no treatment or corn oil only. Tissues and immunohistochemistry Whole tissues for BCI-glu staining were...

McCutcheon, Susan C; Jones, Ken; Cumming, Sarah A; Kemp, Richard; Ireland-Zecchini, Heather; Saunders, John C; Houghton, Carol A; Howard, Louise A; Winton, Douglas J

2010-06-22T23:59:59.000Z

406

Signal separation of musical instruments: simulation-based methods for musical signal decomposition and transcription  

E-Print Network (OSTI)

words. Paul J. Walmsley 4 Abstract This thesis presents techniques for the modelling of musical signals, with particular re gard to monophonic and polyphonic pitch estimation. Musical signals are modelled as a set of notes, each comprising of a set... the time its taken me to get this done. And of course, Dominic's teeth, without whom ... 8 ,1 Notation Symbols b b D..cp, a~ r q G GC g 0 0 {oqh~ {OYh~,Nf {oq} _{q} ll[Xl ,X2J (x) I IN !v! M IQl

Walmsley, Paul Jospeh

2001-05-29T23:59:59.000Z

407

Newsfront 23-29 July 2007, Issue 26  

E-Print Network (OSTI)

Kathmandu l 23-29 July, 2007 l # 26 l Price Rs. 25 l www.newsfront.com.np nf correspondent Nepal is not yet free from fear and possibility of army coup. This is something which appears inevitable if the election to the constituent assembly... our voice. Sushil Koirala did not retort and just smiled at Giris sarcasm. Deceptive nod Soon after the former US President Jimmy Carters visit and wide ranging meeting with the politicians in Kathmandu, the Maoist leaders Prachanda and Baburam...

Ghimire, Yubaraj

408

Newsfront 28 April - 4 May, 2008, Issue 64  

E-Print Network (OSTI)

Kathmandu l 28 Apr-4 May, 2008 l # 64 l Price Rs. 25 www.newsfront.com.np Ph:- Shop 5011685, Factory: 5555459 New outlet in Lainchour also nf correspondent As the speculation about the number is over and the Communist Party of Nepal... on April 25 that GP Koirala must continue to lead the government. Joshi also said it was a wrong to move closer to the Maoists, keeping the parties like UML and the Madheshi Janadhikar Forum (MJF) at bay. Joshi said Maoists also indulged in large scale...

Ghimire, Yubaraj

409

Newsfront 25 November - 1 December 2007, Issue 42  

E-Print Network (OSTI)

25, in presence of fellow Sanyasis and invitees. nf correspondent Former US President Jimmy Carter was received warmly and heard patiently by Nepals key political actors during his recent 3 day visit, his second in six months, but his ideas... Kathmandu l 25 Nov-1 Dec, 2007 l # 42 l Price Rs. 25 www.newsfront.com.np Are you tired/sick, physically and men- tally? Why dont you try our Center? We strengthen your body and mind with dynamic human touch using oriental my- thology Our...

Ghimire, Yubaraj

410

Newsfront 3-9 December 2007, Issue 43  

E-Print Network (OSTI)

Kathmandu l 3-9 Dec, 2007 l # 43 l Price Rs. 25 www.newsfront.com.np He ma nta G uru ng nf correspondent Nepal army is believed to have lodged a protest informally with the United States for having given visa to Prabhakar, Deputy leader... electoral atmosphere wil l not be estab- lished without all that happening. ne ws fro nt 3-9 Dec, 20076 Debating Development Manish Gautam Rita (name changed), 25, is a mother of a five year old child. Both the mother and the child are infected with HIV...

Ghimire, Yubaraj

411

Newsfront 25 June - 1 July 2007, Issue 22  

E-Print Network (OSTI)

memorial at Madi. Now, that is fair journalism. But let newsfront come out in a bigger size. Paying Rs. 25 for 12 thin pages is something that at least I do not feel comfortable with. Tejendra Karki Paknajole, Kathmandu Carters visit Too much has been... Kathmandu l 25 June-1 July, 2007 l # 22 l Price Rs. 25 nf correspondent After prolonged confusion, debate and discussions, the government has fixed 22 November as the date for holding Constituent Assembly (CA) election. This was decided...

Ghimire, Yubaraj

412

Newsfront 17-23 December 2007, Issue 45  

E-Print Network (OSTI)

Kathmandu l 17-23 Dec, 2007 l # 45 l Price Rs. 25 www.newsfront.com.np Bh asw or Ojh a nf correspondent Finally, GP Koirala seems to be able to prolong his rule marred by defaults and poor delivery at least till April based on a power... States President Jimmy Carters visit in November despite the election having been put off, took place largely because many donor agencies had already funded Carter Centers visit here, and his not coming here would have meant having to return that money...

Ghimire, Yubaraj

413

Newsfront 26 March - 1 April 2007, Issue 9  

E-Print Network (OSTI)

Kathmandu l 26 Mar-1 Apr 2007 l # 9 l Price Rs. 25 NF correspondent Waves of NGO led agitation and protests of political nature have not only come as a headache for the Government, but emerged as an entirely new issue for the international... . Shrestha, an Ethno- botanist says Kangchenjunga region is floristically rich. It has nearly 2,000 species of flowering plants. Several species are found to be endemic to the Himalayas. Apart from that, Kangchenjunga region has 25 species of endemic...

Ghimire, Yubaraj

414

Newsfront 30 July - 5 August 2007, Issue 27  

E-Print Network (OSTI)

Kathmandu l 30 July - 5 August, 2007 l # 27 l Price Rs. 25 l www.newsfront.com.np Da mo dar bh and ari nf correspondent Despite governments rhetoric that it is committed to hold elections to the constituent assembly on November 22... of office on July 25. Prime Minister G P Koirala who is the president of Nepali Congress also has been acting as head of the government as well as head of the State under the interim constitution. All crews and the ground staff of the Nepal airlines...

Ghimire, Yubaraj

415

Newsfront 7-13 April 2008, Issue 61  

E-Print Network (OSTI)

Kathmandu l 7-13 Apr, 2008 l # 61 l Price Rs. 25 www.newsfront.com.np Ph:- Shop 5011685, Factory: 5555459 New outlet in Lainchour also Nir aj Sa pko ta nf correspondent Amidst hopes and doubts, an estimated 17.6 million voters are set to go... to the poll this week on April 10 as world watches with vigilant eyes. At least 1000 international observers led by former US President Jimmy Carter will be observing the poll as fears rise that they may not be free from violence, intimidation and rigging...

Ghimire, Yubaraj

416

Newsfront 21-27 April 2008, Issue 63  

E-Print Network (OSTI)

Kathmandu l 21-27 Apr, 2008 l # 63 l Price Rs. 25 www.newsfront.com.np Ph:- Shop 5011685, Factory: 5555459 New outlet in Lainchour also nf correspondent Prime Minister GP Koirala has not yet accepted his defeat, nor is there any sign of his... with the Maoists after the Congress party reviews its poll performance and its future role in the new political context. The two-day review meeting is slated for April 24 and 25. Individual leaders and parliamentarians have been told not to hold press conference...

Ghimire, Yubaraj

417

Newsfront 8-14 October 2007, Issue 37  

E-Print Network (OSTI)

Kathmandu l 8-14 Oct, 2007 l # 37 l Price Rs. 25 www.newsfront.com.np nf correspondent The downslide is complete. From a national hero to South Asia's legend, GP Koirala is now counting his days since the prime minister is now looking for a... ' that parliament should declare Nepal a republic when it meets next week. UN Secretary General Ban Ki Moon, the United States of America, European Union and the Carter Center have expressed their disappointment over the postpone- ment of the polls, and asked key...

Ghimire, Yubaraj

418

Nickel-induced down-regulation of {Delta}Np63 and its role in the proliferation of keratinocytes  

SciTech Connect

Epidemiological, animal, and cell studies have demonstrated that nickel compounds are human carcinogens. The mechanisms of their carcinogenic actions remain to be investigated. p63, a close homologue of the p53 tumor suppressor protein, has been linked to cell fate determination and/or maintenance of self-renewing populations in several epithelial tissues, including skin, mammary gland, and prostate. {Delta}Np63, a dominant negative isoform of p63, is amplified in a variety of epithelial tumors including squamous cell carcinomas and carcinomas of the prostate and mammary glands. The present study shows that nickel suppressed {Delta}Np63 expression in a short-time treatment (up to 48 h). Nickel treatment caused activation of NF-{kappa}B. Blockage of NF-{kappa}B partially reversed nickel-induced {Delta}Np63 suppression. Nickel decreased interferon regulatory factor (IRF) 3 and IRF7, IKK{epsilon}, and Sp100. Over-expression of IRF3 increased {Delta}Np63 expression suppressed by nickel. Nickel was able to activate p21, and its activation was offset by the over-expression of {Delta}Np63. In turn, elevated p63 expression counteracted the ability of nickel to restrict cell growth. The present study demonstrated that nickel decreased interferon regulatory proteins IRF3 and IRF7, and activated NF-{kappa}B, resulting in {Delta}Np63 suppression and then p21 up-regulation. {Delta}Np63 plays an important role in nickel-induced cell proliferation. - Highlights: > Ni suppressed {Delta}Np63 expression in HaCat cells. > Ni activated NF-{kappa}B, decreased expressions of IRF3 and IRF7, IKK{epsilon}, and Sp100. > Over-expression of IRF3 increased {Delta}Np63 expression suppressed by Ni. > Ni activated p21, and its activation was offset by over-expression of {Delta}Np63. > Elevated p63 expression counteracted the ability of nickel to restrict cell growth.

Zhang Zhuo, E-mail: zhuo.zhang@uky.edu [Department of Preventive Medicine and Environmental Health, University of Kentucky, 121 Washington Avenue, Lexington, KY 40536 (United States); Li Wenqi [Department of Preventive Medicine and Environmental Health, University of Kentucky, 121 Washington Avenue, Lexington, KY 40536 (United States); Cheng Senping [Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY 40536 (United States); Yao Hua [Department of Stomatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003 (China); Zhang Fan; Chang Qingshan [Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY 40536 (United States); Ke Zunji [Department of Internal Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536 (United States); Wang Xin; Son, Young-Ok [Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY 40536 (United States); Luo Jia [Department of Internal Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536 (United States); Shi Xianglin [Graduate Center for Toxicology, University of Kentucky, 1095 VA Drive, Lexington, KY 40536 (United States)

2011-06-15T23:59:59.000Z

419

Khesbn no. 73-74 - October 1973 - Journal  

E-Print Network (OSTI)

1ttr" ;ll:p yrl$tyD .typ,'.rtD! 't-f.tN;r ty] rJ)D fNf nylDnYt! LfY .1Y)tl:t't 7:1tf 4n) ''rtD r''N 'ty:)y1] ,)xprno l5Ni2 9t tgt OY l0t'l'ly) rtD ': r)N iTtNluyr Ds'r tN Jtrl'l '

Admin, LAYCC

1973-01-01T23:59:59.000Z

420

Nucleon excited states on the lattice  

E-Print Network (OSTI)

We study the pion-nucleon system in s-wave in the framework of lattice QCD in order to gain new information on the nucleon excited states. We perform simulations for $n_f =2$ mass degenerate light quarks at a pion mass of 266 MeV. The results show that including the two-particle states drastically changes the energy levels. The variational analysis and the distillation approach play an important role in the extraction of the energy levels. The phase shift analysis allows to extract information on the resonance nature of the observed states.

C. B. Lang; V. Verduci

2013-04-15T23:59:59.000Z

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Nucleon excited states on the lattice  

E-Print Network (OSTI)

We study the pion-nucleon system in s-wave in the framework of lattice QCD in order to gain new information on the nucleon excited states. We perform simulations for $n_f =2$ mass degenerate light quarks at a pion mass of 266 MeV. The results show that including the two-particle states drastically changes the energy levels. The variational analysis and the distillation approach play an important role in the extraction of the energy levels. The phase shift analysis allows to extract information on the resonance nature of the observed states.

Lang, C B

2013-01-01T23:59:59.000Z

422

Search for the IR fixed point in the Twisted Polyakov Loop scheme (II)  

E-Print Network (OSTI)

We measure the renormalized coupling in the Twisted Polyakov loop scheme for SU(3) gauge theory coupled with $N_f=12$ fundamental fermions. To find the infrared fixed point of this theory, we focus on the step scaling function for the renormalized coupling. We take the continuum limit using the linear function of $(a/L)^2$ and a constant fit function. We find that there is a sizeable systematic error due to the choice of the continuum extrapolation function in the low energy region. We will give some directions to reduce the systematic errors.

Etsuko Itou; Tatsumi Aoyama; Masafumi Kurachi; C. -J. David Lin; Hideo Matsufuru; Hiroshi Ohki; Tetsuya Onogi; Eigo Shintani; Takeshi Yamazaki

2010-11-02T23:59:59.000Z

423

Search for the IR fixed point in the twisted Polyakov loop scheme  

E-Print Network (OSTI)

We present a non-perturbative study of the running coupling constant in the Twisted Polyakov Loop (TPL) scheme. We investigate how the systematic and statistical errors can be controlled {\\it via} a feasibility study in SU(3) pure Yang-Mills theory. We show that our method reproduces the perturbative determination of the running coupling in the UV. In addition, our numerical result agrees with the theoretical prediction of this coupling constant in the IR. We also present our preliminary results for $N_f=12$ QCD, where an IR fixed point may be present.

Erek Bilgici; Antonino Flachi; Etsuko Itou; Masafumi Kurachi; C. -J. David Lin; Hideo Matsufuru; Hiroshi Ohki; Tetsuya Onogi; Eigo Shintani; Takeshi Yamazaki

2009-10-21T23:59:59.000Z

424

V-210: HP LaserJet Pro Printer Bug Lets Remote Users Access Data |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

V-210: HP LaserJet Pro Printer Bug Lets Remote Users Access Data V-210: HP LaserJet Pro Printer Bug Lets Remote Users Access Data V-210: HP LaserJet Pro Printer Bug Lets Remote Users Access Data August 3, 2013 - 2:37am Addthis PROBLEM: A vulnerability was reported in HP Printers. A remote user can obtain potentially sensitive information. PLATFORM: HP LaserJet Pro products ABSTRACT: A potential security vulnerability has been identified with certain HP LaserJet Pro printers. The vulnerability could be exploited remotely to gain unauthorized access to data. REFERENCE LINKS: SecurityTracker Alert ID 1028869 CVE-2013-4807 Vendor URL IMPACT ASSESSMENT: Medium DISCUSSION: The following models are affected: HP LaserJet Pro P1102w CE657A/CE658A HP LaserJet Pro P1606dn CE749A HP LaserJet Pro M1212nf MFP CE841A HP LaserJet Pro M1213nf MFP CE845A

425

REQUEST BY SIEMENS WESTINGHOUSE POWER CORPORATION FOR AN ADVANCE WAIVER OF DOMESTIC AND FOREIGN RIGHTS IN  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

U5-30-Z002 04:U5pm Frorm-NlIIUNAL I Nf-NWCY L;CHNULULOY LABUKAI UKY -YI-U4L b4LL 1-411 r.uu6/uuJ U5-30-Z002 04:U5pm Frorm-NlIIUNAL I Nf-NWCY L;CHNULULOY LABUKAI UKY -YI-U4L b4LL 1-411 r.uu6/uuJ r -J Statement of Considerations REQUEST BY SIEMENS WESTINGHOUSE POWER CORPORATION FOR AN ADVANCE WAIVER OF DOMESTIC AND FOREIGN RIGHTS IN SUBJECT INVENTIONS MADE IN THE COURSE OF OR UNDER DEPARTMENT OF ENERGY CONTRACT NO. DE-AC26-98FT40355; DOE WAIVER DOCKET W(A)-98-009 [CH-0967] Siemens Westinghouse Power Corporation (hereinafter referred to as "SWPC"), has made a timely request for an advance waiver to worldwide rights in Subject Inventions made in the course of or under Department of Energy (DOE) Contract No. DE-AC26-98FT40355. The scope of the work calls for SWPC to perform a conceptual design and feasibility study of a High Efficiency Fossil-Fueled Power Plant (HEFPP) that incorporates a pressurized tubular solid oxide

426

Sandia National Laboratories: Z Pulsed Power Facility: How Does the Z  

NLE Websites -- All DOE Office Websites (Extended Search)

How Does the Z Machine Work? How Does the Z Machine Work? z-machine i Marx Bank Generator Marx Bank. Each Marx bank has sixty 2.6 μF capacitors (43 nF per Marx when erected) that are charged in parallel and discharged in series. When charged to 85 kV its output voltage is 5.1 MV, and stored energy is 20 MJ for all 36. (For a 90 kV charge it is 5.4 MV and 23 MJ.) When discharged, the peak current of each Marx is about 150 kA with a 1.5 μs time to peak. i Intermediate-Store Capacitor Intermediate-Store Water Capacitor. The output of each Marx is dumped into a 6.5-ft diameter, 10-ft long (24 nF, 3.8 Ω) coaxial cylinder filled with water. This cylinder sits in the oil tank and has polyurethane barriers on each end. It acts as a large capacitor that accumulates the energy from the Marx. When it reaches full voltage (5.1 to 5.4 MV) it is discharged

427

Compatibility Assessment of Advanced Stainless Steels in Sodium  

Science Conference Proceedings (OSTI)

Type 316L stainless steel capsules containing commercially pure sodium and miniature tensile specimens of HT-UPS (austenitic, 14Cr-16Ni), NF-616 (ferritic/martensitic, 9Cr-2W-0.5Mo), or 316L (austenitic, 17Cr-10Ni-2Mo) stainless steel were exposed at 600 or 700 C for 100 and 400 h as a screening test for compatibility. Using weight change, tensile testing, and metallographic analysis, HT-UPS and 316L were found to be largely immune to changes resulting from sodium exposure, but NF-616 was found susceptible to substantial decarburization at 700 C. Subsequently, two thermal convection loops (TCLs) constructed of 316L and loaded with commercially pure sodium and miniature tensile specimens of HT-UPS and 316L were operated for 2000 h each one between 500 and 650 C, the other between 565 and 725 C at a flow rate of about 1.5 cm/s. Changes in specimen appearance, weight, and tensile properties were observed to be very minor in all cases, and there was no metallographic evidence of microstructure changes, composition gradients, or mass transfer resulting from prolonged exposure in a TCL. Thus, it appears that HT-UPS and 316L stainless steels are similarly compatible with commercially pure sodium under these exposure conditions.

Pawel, Steven J [ORNL

2012-01-01T23:59:59.000Z

428

Nepali Aawaz Volume 1, Issue 6, 7-20 December 2005  

E-Print Network (OSTI)

]bLj'sf ufFpn]x?n] dfcf]jfbL x'F eGb} rGbf c;'Ng] Ps gSsnL dfcf]jfbLnfO{ kqmfp u/L ;'/Iff kmf}hnfO{ a'emfP . @@ jlif{o lagf]b vjf; gfdsf lt o'jfn] :yfgLo laBfnosf k|wfgfWofks l8NnL/d0f a/fn / lai0f' /fO{nfO{ @% xhf/ gub dfu u/]sf lyP . To; cl3 ^ sft... 'xn] 38L, ;ft ;o gub / Ps tf]nf ;'gsf] cf}7L+ n'6]/ nusf] lyof] . dfcf]jfbLsf] gfd lnP/ rGbf dfu ug]{ lu/f]x k'jL{ If]qdf clxn] lgs} a9]sf] 5 . dfcf]jfbL eg]k5L rf8} dflg;x? 8/fpg] / s]xL dflg; tyf pBf]uL Aofkf/Lx? af6} *!) nfv ?k}of c;'Ng ;lsg] e...

Shrestha, Kashish Das

429

Heavy-quark free energy at finite temperature with 2+1 flavors of improved Wilson quarks in fixed scale approach  

E-Print Network (OSTI)

The free energy between a static quark and an antiquark is studied by using the color-singlet Polyakov-line correlation at finite temperature. We perform simulations on $32^3 \\times 12$, 10, 8, 6, 4 lattices in the high temperature phase with the RG-improved gluon action and 2+1 flavors of the clover-improved Wilson quark action. Since the simulations are based on the fixed scale approach that the temperature can be varied without changing the spatial volume and renormalization factor, it is possible to investigate temperature dependence of the heavy-quark free energy without any adjustment of the overall constant. We find that, the heavy-quark free energies at short distance converge to the heavy-quark potential evaluated from the Wilson-loop operator at zero temperature, in accordance with the expected insensitivity of short distance physics to the temperature. At long distance, the heavy-quark free energies approach to twice the single-quark free energies, implying that the interaction between heavy quarks is screened. The Debye screening mass obtained from the long range behavior of the heavy-quark free energy is compared with results of the thermal perturbation theory and those of $N_f=2$ and $N_f=0$ lattice simulations.

Y. Maezawa; S. Aoki; S. Ejiri; T. Hatsuda; K. Kanaya; H. Ohno; T. Umeda

2009-11-02T23:59:59.000Z

430

Instantons in the Higgs Phase  

E-Print Network (OSTI)

When instantons are put into the Higgs phase, vortices are attached to instantons. We construct such composite solitons as 1/4 BPS states in five-dimensional supersymmetric U(Nc) gauge theory with Nf(>=Nc) fundamental hypermultiplets. We solve the hypermultiplet BPS equation and show that all 1/4 BPS solutions are generated by an Nc x Nf matrix which is holomorphic in two complex variables, assuming the vector multiplet BPS equation does not give additional moduli. We determine the total moduli space formed by topological sectors patched together and work out the multi-instanton solution inside a single vortex with complete moduli. Small instanton singularities are interpreted as small sigma-model lump singularities inside the vortex. The relation between monopoles and instantons in the Higgs phase is also clarified as limits of calorons in the Higgs phase. Another type of instantons stuck at an intersection of two vortices and dyonic instantons in the Higgs phase are also discussed.

Minoru Eto; Youichi Isozumi; Muneto Nitta; Keisuke Ohashi; Norisuke Sakai

2004-12-06T23:59:59.000Z

431

QCD matrix elements + parton showers.  

E-Print Network (OSTI)

(q, Q)?g(Q1, q) ? Q Q1 dq? ?q(q?, Q)?g(Q1, q?) + ? Q Q1 dq ?q(q, Q)?g(Q1, q) ? q Q1 dq? ?g(q?, q)?g(Q1, q?) + ? Q Q1 dq ?q(q, Q)?g(Q1, q) ? q Q1 dq? ?f(q?)?f (Q1, q?) } (2.4) where ?q,g,f are q ? qg, g ? gg and g ? qq branching probabilities ?q(q, Q... ) = 2CF pi ?S(q) q ( ln Q q ? 3 4 ) (2.5) ?g(q, Q) = 2CA pi ?S(q) q ( ln Q q ? 11 12 ) (2.6) ?f(q) = Nf 3pi ?S(q) q , (2.7) CF = (N2c ?1)/2Nc and CA = Nc for Nc colours, Nf is the number of active flavours, and ?q,g are the quark and gluon Sudakov form...

Catani, S; Krauss, F; Kuhn, R; Webber, Bryan R

432

Scale-dependent mass anomalous dimension from Dirac eigenmodes  

E-Print Network (OSTI)

We investigate the eigenmodes of the massless Dirac operator to extract the scale-dependent fermion mass anomalous dimension gamma_m(mu). By combining simulations on multiple lattice volumes, and when possible several gauge couplings, we are able to measure the anomalous dimension across a wide range of energy scales. The method that we present is universal and can be applied to any lattice model of interest, including both conformal or chirally broken systems. We consider SU(3) lattice gauge theories with Nf=4, 8 and 12 light or massless fermions. The 4-flavor model behaves as expected for a QCD-like system and demonstrates that systematic effects are manageable in practical lattice calculations. Our 12-flavor results are consistent with the existence of an infrared fixed point, at which we predict the scheme-independent mass anomalous dimension gamma_m^*=0.32(3). For the 8-flavor model we observe a large anomalous dimension across a wide range of energy scales. Further investigation is required to determine whether Nf=8 is chirally broken and walking, or if it possesses a strongly-coupled conformal fixed point.

Anqi Cheng; Anna Hasenfratz; Gregory Petropoulos; David Schaich

2013-01-07T23:59:59.000Z

433

Alterations in transcription factor binding in radioresistant human melanoma cells after ionizing radiation  

Science Conference Proceedings (OSTI)

We analyzed alterations in transcription factor binding to specific, known promoter DNA consensus sequences between irradiated and unirradiated radioresistant human melanoma (U1-Mel) cells. The goal of this study was to begin to investigate which transcription factors and DNA-binding sites are responsible for the induction of specific transcripts and proteins after ionizing radiation. Transcription factor binding was observed using DNA band-shift assays and oligonucleotide competition analyses. Confluence-arrested U1-Mel cells were irradiated (4.5 Gy) and harvested at 4 h. Double-stranded oligonucleotides containing known DNA-binding consensus sites for specific transcription factors were used. Increased DNA binding activity after ionizing radiation was noted with oligonucleotides containing the CREB, NF-kB and Sp1 consensus sites. No changes in protein binding to AP-1, AP-2, AP-3, or CTF/NF1, GRE or Oct-1 consensus sequences were noted. X-ray activation of select transcription factors, which bind certain consensus sites in promoters, may cause specific induction or repression of gene transcription. 22 refs., 2 figs.

Sahijdak, W.M.; Yang, Chin-Rang; Zuckerman, J.S.; Meyers, M.; Boothman, D.A. [Univ. of Wisconsin, Madison, WI (United States)

1994-04-01T23:59:59.000Z

434

A Crack in the Conformal Window  

E-Print Network (OSTI)

In {\\cal N} = 2 superconformal three-dimensional field theory the R-symmetry is determined by locally maximizing the free energy F on the three-sphere. Using F-maximization, we study the {\\cal N} = 2 supersymmetric U(N_c) gauge theory coupled to N_f pairs of fundamental and anti-fundamental superfields in the Veneziano large N_c limit, where x = N_f / N_c is kept fixed. This theory has a superconformal window 1 \\leq x \\leq \\infty, while for x window" - a critical value x_c \\approx 1.45 where the monopole operators reach the unitarity bound. To continue the theory to x < x_c we assume that the monopoles become free fields, leading to an accidental global symmetry. Using the Aharony dual description of the theory for x < x_c allows us to determine the R-charges and F for 1 \\leq x < x_c. Adding a Chern-Simons term removes the transition at x_c. In these more general theories we study the scaling dimensions of meson operators as functions of x and \\kappa = |k| / N_c. We find that there is an interesting transition in behavior at \\kappa = 1.

Benjamin R. Safdi; Igor R. Klebanov; Jeongseog Lee

2012-12-18T23:59:59.000Z

435

Sensitization of vascular smooth muscle cell to TNF-{alpha}-mediated death in the presence of palmitate  

SciTech Connect

Saturated free fatty acids (FFAs), including palmitate, can activate the intrinsic death pathway in cells. However, the relationship between FFAs and receptor-mediated death pathway is still unknown. In this study, we have investigated whether FFAs are able to trigger receptor-mediated death. In addition, to clarify the mechanisms responsible for the activation, we examined the biochemical changes in dying vascular smooth muscle cell (VSMC) and the effects of various molecules to the receptor-mediated VSMC death. Tumor necrosis factor (TNF)-{alpha}-mediated VSMC death occurred in the presence of sub-cytotoxic concentration of palmitate as determined by assessing viability and DNA degradation, while the cytokine did not influence VSMC viability in the presence of oleate. The VSMC death was inhibited by the gene transfer of a dominant-negative Fas-associated death domain-containing protein and the baculovirus p35, but not by the bcl-xL or the c-Jun N-terminal kinase (JNK) binding domain of JNK-interacting protein-1, in tests utilizing recombinant adenoviruses. The VSMC death was also inhibited by a neutralizing anti-TNF receptor 1 antibody, the caspase inhibitor z-VAD, and the cathepsin B inhibitor CA074, a finding indicative of the role of both caspases and cathepsin B in this process. Consistent with this finding, caspase-3 activation and an increase in cytosolic cathepsin B activity were detected in the dying VSMC. Palmitate inhibited an increase of TNF-{alpha}-mediated nuclear factor kappa B (NF-{kappa}B) activity, the survival pathway activated by the cytokine, by hindering the translocation of the NF-{kappa}B subunit of p65 from the cytosol into the nucleus. The gene transfer of inhibitor of NF-{kappa}B predisposed VSMC to palmitate-induced cell death. To the best of our knowledge, this study is the first report to demonstrate the activation of TNF-{alpha}-mediated cell death in the presence of palmitate. The current study proposes that FFAs would take part in deleterious vascular consequences of such patients with elevated levels of FFAs as diabetics and obese individuals via the triggering of receptor-mediated death pathways of VSMC.

Rho, Mun-Chual [Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejon (Korea, Republic of); Ah Lee, Kyeong [Department of Pharmacology, School of Medicine, Pusan National University and Medical Research Institute, 10 Ami-dong 1 ga, Seo-gu, Busan 602-739 (Korea, Republic of); Mi Kim, Sun [Department of Pharmacology, School of Medicine, Pusan National University and Medical Research Institute, 10 Ami-dong 1 ga, Seo-gu, Busan 602-739 (Korea, Republic of); Sik Lee, Chang [Department of Pharmacology, School of Medicine, Pusan National University and Medical Research Institute, 10 Ami-dong 1 ga, Seo-gu, Busan 602-739 (Korea, Republic of); Jeong Jang, Min [Department of Pharmacology, School of Medicine, Pusan National University and Medical Research Institute, 10 Ami-dong 1 ga, Seo-gu, Busan 602-739 (Korea, Republic of); Kook Kim, Young [Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejon (Korea, Republic of); Sun Lee, Hyun [Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejon (Korea, Republic of); Hyun Choi, Yung [Department of Biochemistry, Dongeui University College of Oriental Medicine, Dongeui University Graduate School, Busan (Korea, Republic of); Yong Rhim, Byung [Department of Pharmacology, School of Medicine, Pusan National University and Medical Research Institute, 10 Ami-dong 1 ga, Seo-gu, Busan 602-739 (Korea, Republic of); Kim, Koanhoi [Department of Pharmacology, School of Medicine, Pusan National University and Medical Research Institute, 10 Ami-dong 1 ga, Seo-gu, Busan 602-739 (Korea, Republic of)]. E-mail: koanhoi@pusan.ac.kr

2007-05-01T23:59:59.000Z

436

New CYP1 genes in the frog Xenopus (Silurana) tropicalis: Induction patterns and effects of AHR agonists during development  

Science Conference Proceedings (OSTI)

The Xenopus tropicalis genome shows a single gene in each of the four cytochrome P450 1 (CYP1) subfamilies that occur in vertebrates, designated as CYP1A, CYP1B1, CYP1C1, and CYP1D1. We cloned the cDNAs of these genes and examined their expression in untreated tadpoles and in tadpoles exposed to waterborne aryl hydrocarbon receptor agonists, 3,3',4,4',5-pentachlorobiphenyl (PCB126), {beta}-naphthoflavone ({beta}NF), or indigo. We also examined the effects of PCB126 on expression of genes involved in stress response, cell proliferation, thyroid homeostasis, and prostaglandin synthesis. PCB126 induced CYP1A, CYP1B1, and CYP1C1 but had little effect on CYP1D1 (77-, 1.7-, 4.6- and 1.4-fold induction versus the control, respectively). {beta}NF induced CYP1A and CYP1C1 (26- and 2.5-fold), while, under conditions used, indigo tended to induce only CYP1A (1.9-fold). The extent of CYP1 induction by PCB126 and {beta}NF was positively correlated to the number of putative dioxin response elements 0-20 kb upstream of the start codons. No morphological effect was observed in tadpoles exposed to 1 nM-10 {mu}M PCB126 at two days post-fertilization (dpf) and screened 20 days later. However, in 14-dpf tadpoles a slight up-regulation of the genes for PCNA, transthyretin, HSC70, Cu-Zn SOD, and Cox-2 was observed two days after exposure to 1 {mu}M PCB126. This study of the full suite of CYP1 genes in an amphibian species reveals gene- and AHR agonist-specific differences in response, as well as a much lower sensitivity to CYP1 induction and short-term toxicity by PCB126 compared with in fish larvae. The single genes in each CYP1 subfamily may make X. tropicalis a useful model for mechanistic studies of CYP1 functions.

Joensson, Maria E., E-mail: maria.jonsson@ebc.uu.se [Dept of Environmental Toxicology, Evolutionary Biology Centre, Uppsala University, Norbyvaegen 18A, 752 36 Uppsala (Sweden); Biology Department, Redfield 3-42 MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA, 02543 (United States); Berg, Cecilia [Dept of Environmental Toxicology, Evolutionary Biology Centre, Uppsala University, Norbyvaegen 18A, 752 36 Uppsala (Sweden); Goldstone, Jared V.; Stegeman, John J. [Biology Department, Redfield 3-42 MS 32, Woods Hole Oceanographic Institution, Woods Hole, MA, 02543 (United States)

2011-01-15T23:59:59.000Z

437

Anti-inflammatory and antifibrotic effects of methyl palmitate  

Science Conference Proceedings (OSTI)

Methyl palmitate (MP) has been shown earlier to inhibit Kupffer cells and rat peritoneal macrophages. To evaluate the potential of MP to inhibit the activation of other macrophages, RAW cells (macrophages of alveolar origin) were treated with varying concentrations of MP (0.25, 0.5, 1 mM). Assessment of cytotoxicity using MTT assay revealed that 0.25 and 0.5 mM are not toxic to RAW cells. MP was able to inhibit the phagocytic function of RAW cells. Treatment of cells with MP 24 hours prior to LPS stimulation significantly decreased nitric oxide release and altered the pattern of cytokines release; there was a significant decrease in TNF-{alpha} and a significant increase in IL-10 compared to the controls. However, there is a non-significant change in IL-6 level. Furthermore, phosphorylation of inhibitory kappa B (I{kappa}B{alpha}) protein was significantly decreased in RAW cells treated with 0.5 mM MP after LPS stimulation. Based upon the in-vitro results, it was examined whether MP treatment will be effective in preventing bleomycin-induced lung inflammation and fibrosis in-vivo. Bleomycin given by itself caused destruction of the lung architecture characterized by pulmonary fibrosis with collapse of air alveoli and emphysematous. Bleomycin induced a significant increase in hydroxyproline level and activated NF-{kappa}B, p65 expression in the lung. MP co-treatment significantly ameliorated bleomycin effects. These results suggest that MP has a potential of inhibiting macrophages in general. The present study demonstrated for the first time that MP has anti-inflammatory and antifibrotic effect that could be through NF-kB inhibition. Thus MP like molecule could be a promising anti-inflammatory and antifibrotic drug. - Research Highlights: >Methyl palmitate is a universal macrophage inhibitor. >It could be a promising nucleus of anti-inflammatory and antifibrotic drugs. >The underlying mechanism of these effects could be through NF-kB inhibition.

El-Demerdash, Ebtehal, E-mail: ebtehal_dm@yahoo.com

2011-08-01T23:59:59.000Z

438

U.S. Department of Energy Categorical Exclusion Determination Form  

NLE Websites -- All DOE Office Websites (Extended Search)

Electrochemical Fluorination in Molten Fluoride Salts Electrochemical Fluorination in Molten Fluoride Salts Savannah River Site Aiken/Aiken/South Carolina This EEC covers activities in C105/110 related to development of an electrochemical fluorination process to separate selected metals (non- RCRA) from depleted uranium. The goal of the process is to convert depleted uranium metal (U) to gaseous uranium hexafluoride (UF6) that can be easily separated from solution while other metallic constituents remain as metals or are converted to non-volatile fluoride salts. The electrochemical fluorination process will be conducted in molten fluoride eutectic salts at temperatures above 300°C. The electrochemical fluorination process will be carried out using the fluorinating agents such as NF3, XeF2, and F2. Additional inert gases or vacuum may be used in

439

u.s. DEPARTMENT OF ENER GY EERE PROJECT MANAGEMENT CENTER NEPA DETERMINATION  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

REClPIENT:Optony Inc. REClPIENT:Optony Inc. PROJECf Southwest Solar Transformation Initiative TITLE: Page 1 of2 STATE: CA Funding Opportunity Announcement Number Procuremrnt Instrument Number NEPA Control Number CID Number DOE·FQA.Q()()()549 DE-EEOOO5682 GF0-0005682-OO1 0 Based on my review of the information concerning the proposw action, as NEPA Compliance Offic:er (authorized under DOE Order 451.IA),1 have made the follOwing determination : ex, EA, [IS APPENDIX AND NUMBER: Ocscription : A11 Technical advice a nd as s istance to organizations Technical advice and planning assistance to international, national, state, and local organizabons A91nf ormation gathering. analysis, and dissemination Informabon gathenng (indudlng, but not limited 10, literature surveys, inventories, site VISits, and audits), data analysis

440

gropuUCSB2013-07-30_Webinar.ppt  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Characterization of a Larger Scale NFA Heat: FCRD-NFA1 UCSB Performers: G. R. Odette, N. J. Cunningham, Y. Wu, E. T. Yamamoto Primary Collaborators D. T. Hoelzer (ORNL), S. A. Maloy (LANL) 7/31/13 Primary UCSB Sponsor DOE Office of Nuclear Energy NEUP and LANL Secondary Sponsor DOE Office of Fusion Energy Sciences (irradiation studies) * Systematic development of 'best practice" alloy design processing path for larger heat of 14YWT NFA - FCRD NFA1 * Guided by step by step characterization at UCSB and collaborators using state of the art SANS, APT and TEM techniques - including NF phase and OR * Determined critical parameters - milling time, consolidation temperature, O-level, post consolidation deformation processing * ORNL produced PM2 as the final precursor alloy

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Microsoft PowerPoint - Dose Ranges 24Jan 05.ppt  

NLE Websites -- All DOE Office Websites (Extended Search)

20 40 60 20 40 60 80 100 rem NRC Dose Limit for Public 100 mrem/yr = 1 mSv/yr (DOE, ICRP, NCRP) ANSI standard N43.17 Personnel scanner, max = 25 mrem/yr Cleanup criteria for site decommissioning/ license termination 25 mrem/yr NCRP "Negligible Dose" Medical Diagnostics (A-J) A C D E G B Temporary "Special Case" annual Public Limit (NRC, DOE) NRC Dose Limit for Workers = 5 rem/yr = 50 mSv/yr Cancer Epidemiology Life Span Study (A-bomb survivors) ( Chart compiled by NF Metting, Office of Science DOE/BER; 24Jan2005,"Orders of Magnitude") Absorbed dose: 100 rad = 1 Gray Dose equivalent: 100 rem = 1 Sievert 100 mrem = 1 mSv (1 rem = 1 rad for x- and gamma- rays) Estimated dose for

442

NVN-078688 | Open Energy Information  

Open Energy Info (EERE)

8688 8688 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-078688 Case Data Survey Type Unsurveyed - uprotracted Case Status Authorized Case Type GEO_LEASE_NONCOMPETITI Total Acreage 2525 Bid Price/Acre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 REESE RIVER GEO POWER LLC Lessee 2 none provided Effective Date 10/1/2004 Expire Date Held By Production (HBP) HBP Date RoyaltyRate Most Recent Action EFFECTIVE DATE Most Recent Action Date 10/1/2004 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0230N Range 0430E Section 3 Aliquot nw,s2 Retrieved from "http://en.openei.org/w/index.php?title=NVN-078688&oldid=661594" Category: BLM Geothermal Case What links here

443

Federal Utility Partnership Working Group - Utility Interconnection Panel  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

WORKING GROUP - Utility Interconnection Panel M. Renee Jewell, Program/Energy Manager, & Contracting Officer, Forest Service (reneejewell@fs.fed.us) SCENARIO: Fed Agencies had Solar PV Projects To Connect with Utility in California * United States (US) Forest Service (FS) - 1 small Solar Photovoltaic (PV) project; and - 1 small Renewable project (Solar PV) exporting energy to grid. * U.S. National Park Service (NPS) - 24 Small Solar Photovoltaic projects. * U.S. Dept. of Veterans Affairs (VA) - 6 Renewable generation projects of different sizes. FS Region 5 (California) - Solar Photovoltaic Installations Solar PV Project @ Mono Lake Visitor Center (Inyo NF) Solar PV Project (net exporter) @ San Dimas Technology and Development Center SITUATION - Utility Wanted Feds to Sign Its

444

RECIPIENT:Semprius  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Semprius Semprius u.s. DEPARTr-IEN T OF ENERGY EERE PROJECT MAN AGEMEN T CENT ER NEPA DETERMINATION Page 1 of2 STATE: NC PROJECT TITLE: SAl Incubator - Semprius - Massively Parallel Microcell-based Module Array; NREl Tracking No. 09- 036a Funding Opportunity Announcement Number Procur~mtnt Instrument Number NEPA Control Number elD Number NREL-09-036a G010337 Based on my review of the information concuning the proposed action, as Nf:PA Compliance Officer (authorized undcr DOE Order 45 I. IA), I have made the following determination: ex, EA, EIS APPENDIX ANI) NUMBER: Description: 83.6 Siting, construction (or modification), operation, and decommissioning of facilities for indoor bench-scale research projects and conventional laboratory operations (for example, preparation of chemical standards and sample analysis);

445

Visions for Data Management and Remote Collaboration on ITER  

NLE Websites -- All DOE Office Websites (Extended Search)

Transport And Density Peaking At Low Transport And Density Peaking At Low Collisionality On Alcator C-Mod 49 th Annual Meeting of APS - DPP Orlando, 11/14/2007 M. Greenwald, J.W. Hughes, D. Mikkelsen, J. Terry, Alcator Group C. Angioni, H. Weisen M. Greenwald, et al., APS-DPP November 2007 Particle Transport and Density Profiles ● We want to be able to predict density profile - Better fusion performance with moderate density peaking - Effects on stability, divertor operation etc. ● Results from ASDEX (Angioni et al., PRL 2003), JET (H. Weisen, et al., NF 2005) show increase in density peaking at low ν* for H-mode plasmas. - Central fueling (NBI) can play an important role as well. ● Scales to ITER (with weak fueling): n e (0)/ ~ 1.4-1.5 ● In this talk, we'll also look at an additional effect: the role of safety factor

446

NVN-079306 | Open Energy Information  

Open Energy Info (EERE)

6 6 Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home BLM Geothermal Case: NVN-079306 Case Data Survey Type B Case Status Authorized Case Type GEO_LSE_NONCOMP_PRE_2005 Total Acreage 2140.53 Bid Price/Acre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT RESOURCES INC Lessee 2 none provided Effective Date 7/1/2006 Expire Date Held By Production (HBP) HBP Date RoyaltyRate 10% - 5% - 5% Most Recent Action RLTY RATE -10%- Most Recent Action Date 7/1/2006 Location Information Geothermal Resource Area Meridian 21 State(s) Nevada Township 0270N Range 0320E Section 2 Aliquot nenesw,w2w2sw Retrieved from "http://en.openei.org/w/index.php?title=NVN-079306&oldid=665211" Category: BLM Geothermal Case What links here

447

REGISTRATION LIST P PR RE ES SO OL LI IC CI IT TA AT TI IO ON  

NLE Websites -- All DOE Office Websites (Extended Search)

REGISTRATION LIST REGISTRATION LIST P PR RE ES SO OL LI IC CI IT TA AT TI IO ON N C CO ON NF FE ER RE EN NC CE E August 9, 2011 Holiday Inn Capitol  550 C Street, SW  Washington, DC 20024 Page 1 of 9 Instructions: (iii) Please indicate (by checking the appropriate box) whether the organization you represent is a large business, small business, or not a business. (iv) Please indicate (by checking the appropriate box) whether your name or the name of your organization may be released on the NNSA website as an attendee of this conference. (v) Please provide an email address if you would like it to be released on the NNSA website. An email address cannot be released if you select neither in column (iv). Name Organization Name Large/Small (iii) Release Attendance? (iv) Email (to release)

448

Developing small vacuum spark as an x-ray source for calibration of an x-ray focusing crystal spectrometer  

SciTech Connect

A new technique of x-ray focusing crystal spectrometers' calibration is the desired result. For this purpose the spectrometer is designed to register radiated copper K{alpha} and K{beta} lines by using a flat {alpha}-quartz crystal. This experiment uses pre-breakdown x-ray emissions in low vacuum of about 2.5-3 mbar. At this pressure the pinch will not form so the plasma will not radiate. The anode material is copper and the capacity of the capacitor bank is 22.6 nF. This experiment designed and mounted a repetitive triggering system to save the operator time making hundreds of shots. This emission amount is good for calibration and geometrical adjustment of an optical crystal x-ray focusing spectrometer.

Ghomeishi, Mostafa; Adikan, Faisal Rafiq Mahamd [Photonic Research Group, Department of Electrical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur (Malaysia); Karami, Mohammad [Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur (Malaysia)

2012-10-15T23:59:59.000Z

449

U.S. Department of Energy NEPA Categorical Exclusion Determination Form  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

mail mail u.s. Department of Energy Categorical Exclusion Determination Form Proposed Action Title: Notice of Proposed Rulemaking (NOPR) for Energy Conservation Standards for Commercial Refrigeration Equipment (RIN: 1904-AC19) Program or Field Office: EERE - Buildings Technology Program Location(s) (City/County/State): NfA Proposed Action Description: DOE proposes to adopt amended energy conservation standards for commercial refrigeration equipment. The proposed standards consist of maximum daily energy consumption (MDEC) values as a function of either refrigerated volume or total display area (IDA). DOE proposes that the standards covered in this NQPR, if adopted, would apply to all equipment listed in Table 1.1 of the NOPR and manufactured in, or imported

450

TO: FILE SITE  

Office of Legacy Management (LM)

c)&a sw&?u da r/dwl&e c)&a sw&?u da r/dwl&e ALTERNATE NAME: NAME: --------------------------------------- CITY: 79lA% lo -------------------------- STATE: TYPE OF OPERATION -------------_--_ D Research & Development 0 Production scale tasting ench Scale Process 0 Theoretical Studies 0 Sample & Analysis 0 Facility Typo * Manuf actul 0 Universijt 0 Reaearcti I 0 Governmfn Cl Other ---. 0 Production p Disposal/Staraqe cwQ @oa&' y, a( L:& 0 Prime 0 Subcontract& cl Other i nf ormi 0 Purchase Order + fixed fed, time & mat&: I ---------____ I Contract/Purchase Order # ---------____ I -----------------------------. CONTRACTING PERIOD: -~~----___----_--_ ----------------------------------. OWNERSHiP: AK/PIED AECMED GOVT GOUT CON: !%!E!? EASE!? o_w!!!z? LESE!?

451

Low Dose Radiation Research Program: Gregory A. Kimmel  

NLE Websites -- All DOE Office Websites (Extended Search)

Gregory A. Kimmel Gregory A. Kimmel Pacific Northwest National Laboratory Past Project A Novel Spatially Resolved Cell Irradiator to Study Bystander and Adaptive Responses to Low-LET Radiation. Technical Abstracts 2002 Workshop: Spatially Resolved Single Cell Irradiator to Study Bystander Responses to Low LET Radiation. Resat, M.S., Kimmel, G.A., Miller, J.H., McDonald, J.C., Murphy, M.K., Strom, D.J., Thrall, B.D., and Colson, S.D. 2001 Workshop: Spatially Resolved Single Cell Irradiator to Study Bystander Responses to Low LET Radiation. Resat, M.S., Kimmel, G.A., Miller, J.H., McDonald, J.C., Murphy, M.K., Strom, D.J., Thrall, B.D., Metting, N.F., and Colson, S.D 1999 Workshop: A Novel, Spatially Resolved Cell Irradiator to Study Bystander and Adaptive Responses to Low-LET Radiation.

452

U.S. Department of Energy Categorical Exclusion Determination Form  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Electrochemical Fluorination in Molten Fluoride Salts Electrochemical Fluorination in Molten Fluoride Salts Savannah River Site Aiken/Aiken/South Carolina This EEC covers activities in C105/110 related to development of an electrochemical fluorination process to separate selected metals (non- RCRA) from depleted uranium. The goal of the process is to convert depleted uranium metal (U) to gaseous uranium hexafluoride (UF6) that can be easily separated from solution while other metallic constituents remain as metals or are converted to non-volatile fluoride salts. The electrochemical fluorination process will be conducted in molten fluoride eutectic salts at temperatures above 300°C. The electrochemical fluorination process will be carried out using the fluorinating agents such as NF3, XeF2, and F2. Additional inert gases or vacuum may be used in

453

The Mycorrhizal Fungus, Sebacina  

NLE Websites -- All DOE Office Websites (Extended Search)

Mycorrhizal Mycorrhizal Fungus, Sebacina vermifera, Enhances Seed Germination and Biomass Production in Switchgrass (Panicum virgatum L) Sita R. Ghimire & Nikki D. Charlton & Kelly D. Craven Published online: 16 April 2009 # Springer Science + Business Media, LLC. 2009 Abstract Seed dormancy and slow seedling establishment are two major concerns in switchgrass (Panicum virgatum L.) production, often resulting in a poor stand with reduced productivity. Studies were conducted to investigate the stability of artificial associations between switchgrass and the ectomycorrhizal fungus, Sebacina vermifera, and to evaluate the potential benefits of this novel association in seed germination and biomass production. All six strains of S. vermifera tested had a high frequency of colonization on switchgrass roots of a synthetic cultivar NF/GA-993. The positive effects of the associations

454

Low Dose Radiation Research Program: Adaptive Response of Mouse Skin  

NLE Websites -- All DOE Office Websites (Extended Search)

Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Ionizing Radiation: Induction of NF-κB, MnSOD, 14-3-3ζ and Cyclin B1 Authors: Jian Jian Li, Kazi M. Ahmed, Ming Fan, Shaozhong Dong, Douglas R. Spitz, and Cheng-Rong Yu Institutions: Division of Molecular Radiobiology, Purdue University School of Health Sciences, West Lafayette, Indiana; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa; Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland Gene expression profiles demonstrate that a group of key stress-responsive genes are associated with radiation exposure and may contribute to cellular

455

Microsoft PowerPoint - Low Dose Update Metting 6 Dec 2012  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Low Dose DOE's Low Dose Low Dose DOE's Low Dose R di ti R h R di ti R h Radiation Research Radiation Research Program Program g g NF Metting, Sc.D., Program Manager Nuclear Energy Advisory Committee Meeting Nuclear Energy Advisory Committee Meeting L'Enfant Plaza Hotel L'Enfant Plaza Hotel 6 December 2012 Office of Science Office of Biological and Environmental Research DOE's Low Dose Program: DOE s Low Dose Program: Is unique within the U.S. government in focusing on low dose biological research aimed at informing current and future g g national radiation risk policy for the public and the workplace * DOE focuses on worker and public safety from very low dose x- and p y y gamma-ray exposures encountered in energy production and environmental cleanup In contrast: In contrast: * NASA focuses on astronaut safety from high energy particulate radiation

456

Climate VISION: Private Sector Initiatives: Semiconductors  

Office of Scientific and Technical Information (OSTI)

Letters of Intent/Agreements Letters of Intent/Agreements The U.S. semiconductor industry, represented by the members of the Environmental Protection Agency's PFC Reduction/Climate Partnership for the Semiconductor Industry, has committed to reduce absolute perfluorocompound (PFC) emissions by 10% below the 1995 baseline level by the year 2010. Perfluorocompounds include the most potent and long-lived greenhouse gases such as perfluorocarbons (e.g., CF4, C2F6, C3F8), trifluoromethane (CHF3), nitrogen trifluoride (NF3), and sulfur hexafluoride (SF6). The Environmental Protection Agency's (EPA) voluntary semiconductor industry partnership was developed collaboratively with the Semiconductor Industry Association (SIA). EPA, SIA, and the Partner companies (listed below) are working to reduce industry greenhouse gas (GHG) emissions. EPA's

457

table5.1_02  

U.S. Energy Information Administration (EIA) Indexed Site

End Uses of Fuel Consumption, 2002; End Uses of Fuel Consumption, 2002; Level: National Data; Row: End Uses within NAICS Codes; Column: Energy Sources, including Net Electricity; Unit: Physical Units or Btu. Distillate Fuel Oil Coal Net Residual and Natural LPG and (excluding Coal RSE NAICS Total Electricity(b) Fuel Oil Diesel Fuel(c) Gas(d) NGL(e) Coke and Breeze) Other(f) Row Code(a) End Use (trillion Btu) (million kWh) (million bbl) (million bbl) (billion cu ft) (million bbl) (million short tons) (trillion Btu) Factors Total United States 311 - 339 ALL MANUFACTURING INDUSTRIES RSE Column Factors: 0.3 1 1 2.4 1.1 1.4 1 NF TOTAL FUEL CONSUMPTION 16,273 832,257 33 24 5,641 26 53 6,006 3.4 Indirect Uses-Boiler Fuel -- 3,540 20 6

458

eCopy, Inc.  

NLE Websites -- All DOE Office Websites (Extended Search)

submitted manuscript has ooen authored submitted manuscript has ooen authored )y a contr"I"'!N nf the U. S. Government unoer contract No. W-31-109-ENG-38. Accordingly, the U. S. Government retains a nonexclusive, royalty-free license to publish lli r reproduce the published form of this contribution, or allow others to do so, for U. S. Government purposes. LS-183 DIFFERENCE RESONANCE STUDY ON THE ELECTRON STORAGE RING ALADDIN AT SRC* J. Liu APS, Argonne National Laboratory and Dept. of Physics, University of Wisconsin-Madison E. Crosbie, L. Teng, J. Bridges APS, Argonne National Laboratory Argonne, IL 60439, USA K. Symon Dept. of Physics University of Wisconsin-Madison W. Trzeciak Synchrotron Radiation Center, Stoughton, 'VI 53589, USA Abstract \Ve have studied the third-order betatron difference resonance on the elec-

459

. DEPART.MENT OF ENERGY EERE PROJECT MANAGEMENT CENTER NEP.-\. DE  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

DEPART.MENT OF ENERGY DEPART.MENT OF ENERGY EERE PROJECT MANAGEMENT CENTER NEP.-\. DE TERIvllNATION Page 1 of2 RECIPIENT:Delaware State Energy Office STATE: DE PROJECT TITLE: EECBG Subgrant: Lums Pond State Park Natural Gas Conversion Funding Opportunity Announcement Numbl'r DE-FOA-0000013 Procurement Instrument Number DE-EE-0000775 NF.PA Control Number GFO-00OO775-002 cm Number o Based on my review of the information concerning the proposed action, as NEPA Compliance Officer (authorized under DOE Order 451_IA), 1 have made the following determination: cx, EA, EIS APPENDIX ANI) NUMBER: lkscription: 82.5 Safety and environmental improvements of a facility, including replacement and upgrade of facility components. that do not result in a significant change in the expected useful life, design capacity, or function of the facility and during which

460

I"  

Office of Legacy Management (LM)

.., ..6'"w' .., ..6'"w' I, . v -+"+.~ f, :. 6 ~,i.//bJc-iC ' ; 1-i -5' ; i - *> i-i> I ii I-t t n,.,4 ( .I , f ' .I f x c . : ' . ,"", ' C.--c rn ' 2. I _ i ' L :_ ;) --lr>[-0-t. ' I" c j-j! : , :- ) L (, 3 uTALL.URCICAL PROJECT FOmc W-73 The University of Chicago Chicago, Illinois s docurrient consists of--.TL,y. es and ._______ C? . _ - _ _ ._.__ d..nf ______ &?copiesl fig ____________________-----. 2 Series_.. re%~~IC~ 0~ T~WINATI~N OF SUBCONTRACT _ _____ Contract No. 7401-37-146 To: Quality Hardware & Machine Corp. , Subcontractor 5849 N. Ravenswood Ave. (Attn: L. S. Laystrom ) . Chiw Tlllnnin / &xx Gentlemen: You are hereby notified that by reason of normal expiration, a certain subcontract between you and The University of Chic&go

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
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461

TITLE  

Office of Legacy Management (LM)

CULTURAL RESOURCES STUDY CULTURAL RESOURCES STUDY BACKQROUND RESEARCH REPORT Off-NfS Cukural Rasowcmr Studks: Background Research for Project Shot11 Prepared by Maureen King Alvin R. McLane and William Gray Johnson MAY 1993 DESERT RESEARCH INSTITUTE CULTURAL RESOURCES STUDY BACKGROUND RESEARCH REPORT Off-NTS Cultural Resources Studies: Background Research for Project Shoal Prepared by Maureen King Alvin R. McLane and William Gray Johnson Prepared for the U.S. Department of Energy Nevada Field Office Las Vegas, Nevada This document is UNCLASSIFIED Derivative , , ::/>.: ; , . / I : Classifier - & ? " A . + - = / . /.. Desert Research Institute ate.:^^:,'& MAY 1993 The work upon which this report is based was supporred by the U.S. Department of h e r g y under Contract #DE-AC08-90NV10845

462

OAK RIDGE NATIONAL LABORATORY RESULTS OF RADIOLOGICAL  

Office of Legacy Management (LM)

2 7% 2 7% d &y / 7 ORNL/TM- 10076 OAK RIDGE NATIONAL LABORATORY RESULTS OF RADIOLOGICAL ~-T-m -~=- -~ w-~- -"" * ,<.~- ~w&$UREMENTs: TAKEN IN THE NIAGARA FALLS, NEW YORK, AREA (NF002) J. K. Williams B. A. Berven ~.~~;:;-~~~ ~. -,' - ~~ 7, OPERATED BY MARTIN MARIDTA ENERGY SYSTEMS, INC, FOR THE UNITED STATES DEPARTMENT OF ENERGY --... ORNL/TM-10076 HEALTH AND SAFETY RESEARCH DIVISION Nuclear and Chemical Waste Programs (Activity No. AH 10 05 00 0; ONLWCOI) RESULTS OF RADIOLOGICAL MEASUREMENTS TAKEN IN THE NIAGARA FALLS, NEW YORK, AREA (NFOO2) J. K. Williams* and B. A. Berven *Biology Division Date Published November 1986 Investigation Team B. A. Berven - RASA Program Manager W. D. Cottrell - FUSRAP Project Director W. H. Shinpaugh - Field Survey Supervisor

463

ABORATOtiY  

Office of Legacy Management (LM)

ABORATOtiY ABORATOtiY ., . . . .' _ RESULTS OF THE RADIOLOGICAi SURVEY AT SUMITOMO MACHINERY CORPORATION OF AMERICA, 7 MALCOLM AVENUE, TETERBORO;NEW JERSEY (TJoo~) R. D. Foley L. M. Floyd Printed in the United States of America. Available from National Technical ' Information Serwce U.S. Department of Commerce 5265 Port Royal Road, Springfield, Virginia 22161 NTIS price codes-Printed Copy:A03 Microfiche A01 This report was prepared as an aCCo"nf of Work sponsored by an agency 01 Ihe UnifedStalesGovernment.NeithertheUniledStatesGovernmentnoranyagency thereof. nor any of their employees. makes any warranty. express or implied. or a~wrne~ any legal liability or responsibility for the accuracy. completeness. or urelulnesr of any inlormation. apparatus. product. or process disclosed. or

464

EIS-0350-S1: DOE Notice of Availability of the Draft Supplemental  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

-S1: DOE Notice of Availability of the Draft Supplemental -S1: DOE Notice of Availability of the Draft Supplemental Environmental Impact Statement and Notice of Public Hearings EIS-0350-S1: DOE Notice of Availability of the Draft Supplemental Environmental Impact Statement and Notice of Public Hearings Nuclear Facility Portion of the Chemistry and Metallurgy Research Building Replacement Project NNSA, a semiautonomous agency within DOE, proposes to complete the Chemistry and Metallurgy Research Building Replacement (CMRR) Project at Los Alamos National Laboratory (LANL) by constructing the nuclear facility portion (CMRR-NF) of the CMRR Project to provide the analytical chemistry and materials characterization capabilities currently or previously performed in the existing Chemistry and Metallurgy Research (CMR) Building.

465

Victory Electric Coop Assn Inc | Open Energy Information  

Open Energy Info (EERE)

Electric Coop Assn Inc Electric Coop Assn Inc Jump to: navigation, search Name Victory Electric Coop Assn Inc Place Kansas Utility Id 19820 Utility Location Yes Ownership C NERC Location SPP NERC SPP Yes RTO SPP Yes Activity Distribution Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png AE-11 All Electric Service Residential B-11 Small Commercial Service Multi-Phase Industrial B-11 Small Commercial Service Single Phase Commercial DS-11 Domestic Service Residential EDR-04 Economic Development Rider EDR-NF-04 Economic Development Rider No Facilities Charge I-11 Irrigation Service I-B-11 Irrigation Service Center Pivot Drives and Reuse Pumps

466

RECiPIENT:Hidaigo County u.s. DEPARTMENT OF ENERGY EERE PROJECT MANAGEMENT CENTER  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

RECiPIENT:Hidaigo County RECiPIENT:Hidaigo County u.s. DEPARTMENT OF ENERGY EERE PROJECT MANAGEMENT CENTER NEPA DETERMINATION PROJ ECT TITLE: County of Hidalgo Tx - Solar Lights for Colonias ARRA·EECBG (S ) Page 1 of2 STATE : TX .'undlng Opportunity Announcement Number DE-FQAOOOO013 Procurement Instrument Number DE-EE0000912 NF.PA Control Number em Number o Based on my review orlhe information concerning the proposed action, as NEPA Compliance Officer (authorized under DOE Order 4SI.IA), I have made the follo"" ing determination: ex, EA. EIS APPENDIX AND NUMBER: Description: 6 5.1 Actions to conserve energy. demonstrate potential energy conservation , and promote energy--efficJency that do not increase the indoor concentrations of potentially harmful substances. These actions may involve finanCial and technical

467

The kaon semileptonic form factor with near physical domain wall quarks  

E-Print Network (OSTI)

We present a new calculation of the K->pi semileptonic form factor at zero momentum transfer in domain wall lattice QCD with Nf=2+1 dynamical quark flavours. By using partially twisted boundary conditions we simulate directly at the phenomenologically relevant point of zero momentum transfer. We perform a joint analysis for all available ensembles which include three different lattice spacings (a=0.09-0.14fm), large physical volumes (m_pi*L>3.9) and pion masses as low as 171 MeV. The comprehensive set of simulation points allows for a detailed study of systematic effects leading to the prediction f+(0)=0.9670(20)(+18/-46), where the first error is statistical and the second error systematic. The result allows us to extract the CKM-matrix element |Vus|=0.2237(+13/-8) and confirm first-row CKM-unitarity in the Standard Model at the sub per mille level.

Peter A. Boyle; Jonathan M. Flynn; Nicolas Garron; Andreas Juttner; Chris T. Sachrajda; Karthee Sivalingam; James M. Zanotti

2013-05-30T23:59:59.000Z

468

Nepal: Dangerous Plans for Village Militias  

E-Print Network (OSTI)

in Sudama, a village in the eastern Tarai district of Sarlahi some 125 kilometres from Kathmandu. The village, which has a population of about 5,000, is just four kilometres north of the border with the Indian state of Bihar. Sudamas population... If cg'kl:yt x'Fbf csf{] kIfsf] k|e'Tj b]lvPsf] 5 . csf{lt/ ;/sf/n] b]zsf s'gfsfKrfdf km}n]sf ;'/Iff lgsfoxnfO{ ToxfFaf6 p7fP/ x/]s lhNnfdf Pp6f cyjf b'O{cf]6f 7fpFdf alnof] zlQm :yfkgf ug{] s]lGb|s[t sdf08 cjwf/0ff ckgfPsf] 5 . sf7df8f}Faf6 sl...

International Crisis Group

2004-02-17T23:59:59.000Z

469

A new family of anion receptors and their effects on ion pair dissociation and conductivity of lithium salts in non-aqueous solutions  

DOE Green Energy (OSTI)

A new family of anion receptors based on aza-ether compounds have been synthesized. Since the anion complexation of these compounds is not based on either positively charged sites or hydrogen bonding, they have a potential to be used in lithium batteries as electrolyte additives. When these compounds are added into nonaqueous electrolytes using lithium salts, such as LiCl/BF or LiBr/THF, the ionic conductivity can be dramatically increased. Near Edge X-ray Absorption Fine Structure (NF-XAFS) spectroscopy studies show that Cl{sup {minus}} anions are completed with the nitrogen groups in these compounds. The increase in ionic conductivity and the degree of complexation, are both related to the number of R=CF{sub 3}SO{sub 2} groups that are used to substitute the amine hydrogen atoms in these aza-ether compounds.

Lee, H.S.; Yang, X.Q.; McBreen, J. [Brookhaven National Lab., Upton, NY (United States); Okamoto, Y. [Polytechnic Univ., Brooklyn, NY (United States)

1994-08-01T23:59:59.000Z

470

100 Area D4 Project Building Completion Report - July 2007 to December 2008  

Science Conference Proceedings (OSTI)

This report documents the decontamination, decommissioning, and demolition of the 105-NB, 163-N, 183-N, 183-NA, 183-NB, 183-NC, 184-N, 184-NA, 184-NB, 184-NC, 184-ND, 184-NE, 184-NF, 1312-N, 1330-N, 1705-N, 1705-NA, 1706-N, 1712-N, 1714-N, 1714-NA, 1714-NB, 1802-N, MO-050, MO-055, MO-358, MO-390, MO-900, MO-911, and MO-950 facilities in the 100 Area of the Hanford Site. The D4 activities for these facilities include utility disconnection, planning, characterization, engineering, removal of hazardous and radiological contaminated materials, equipment removal, decommissioning, deactivation, decontamination, demolition of the structure, and removal of the remaining slabs.

M. T. Stankovich

2009-04-15T23:59:59.000Z

471

Tika of Dharmapala  

E-Print Network (OSTI)

Jl::thb~J1'1 ljlliltj..l22l1:1?lHll.Ej bJlli1? 'hll':lel'& h4,~ ~:thDJ l::!l.l;jl~h nf: .l:j.Ia.l2 I .E:J!?:~~Hjl'J.I:i 1=jll' .\\:!=Iab1?JlS gj... ~- ~r~ Vim I ~ Sfftr:r~~ 6~0l.fft:rf~;;f~ ar~~1ffu I

unknown

1980-01-01T23:59:59.000Z

472

RECENT PROGRESS TOWARD A MUON RECIRCULATING LINEAR ACCELERATOR  

SciTech Connect

Both Neutrino Factories (NF) and Muon Colliders (MC) require very rapid acceleration due to the short lifetime of muons. After a capture and bunching section, a linac raises the energy to about 900 MeV, and is followed by one or more Recirculating Linear Accelerators (RLA), possibly followed by a Rapid Cycling Synchnotron (RCS) or Fixed-Field Alternating Gradient (FFAG) ring. A RLA reuses the expensive RF linac section for a number of passes at the price of having to deal with different energies within the same linac. Various techniques including pulsed focusing quadruopoles, beta frequency beating, and multipass arcs have been investigated via simulations to improve the performance and reduce the cost of such RLAs.

Slawomir Bogacz, Vasiliy Morozov, Yves Roblin, Kevin Beard

2012-07-01T23:59:59.000Z

473

Nuclear forces in the parity odd sector and the LS forces  

E-Print Network (OSTI)

In this paper, we report our first attempt at determining NN potentials in the parity odd sector including the spin-orbit force in lattice QCD, employing the method to extract successfully parity even NN potentials from Nambu-Bethe-Salpeter (NBS) wave functions through the Schr\\"odinger equation. Using Nf = 2 CP-PACS gauge configurations on a 16^3 x 32 lattice at a = 0.16 fm and m_\\pi \\cong 1.1 GeV, we calculate central, tensor and spin-orbit potentials in the parity odd sector. Although statistical errors are still large, we observe that the qualitative features of these potentials roughly agree with those of phenomenological potentials.

Keiko Murano; for the HALQCD Collaboration

2011-12-09T23:59:59.000Z

474

Cutoff effects on lattice nuclear forces  

E-Print Network (OSTI)

We present a lattice QCD study for the cutoff effects on nuclear forces. Two-nucleon forces are determined from Nambu-Bethe-Salpeter (NBS) wave functions using the HAL QCD method. Lattice QCD simulations are performed employing N_f = 2 clover fermion configurations at three lattice spacings of a = 0.108, 0.156, 0.215 fm on a fixed physical volume of L^3 x T = (2.5 fm)^3 x 5 fm with a large quark mass corresponding to m_\\pi = 1.1 GeV. We observe that while the discretization artifact appears at the short range part of potentials, it is suppressed at the long distance region. The cutoff dependence of the phase shifts and scattering length is also presented.

Takumi Doi; for HAL QCD Collaboration

2013-11-12T23:59:59.000Z

475

Use of Treated Municipal Wastewater as Power Plant Cooling System Makeup Water: Tertiary Treatment versus Expanded Chemical Regimen for Recirculating Water Quality Management  

SciTech Connect

Treated municipal wastewater is a common, widely available alternative source of cooling water for thermoelectric power plants across the U.S. However, the biodegradable organic matter, ammonia-nitrogen, carbonate and phosphates in the treated wastewater pose challenges with respect to enhanced biofouling, corrosion, and scaling, respectively. The overall objective of this study was to evaluate the benefits and life cycle costs of implementing tertiary treatment of secondary treated municipal wastewater prior to use in recirculating cooling systems. The study comprised bench- and pilot-scale experimental studies with three different tertiary treated municipal wastewaters, and life cycle costing and environmental analyses of various tertiary treatment schemes. Sustainability factors and metrics for reuse of treated wastewater in power plant cooling systems were also evaluated. The three tertiary treated wastewaters studied were: secondary treated municipal wastewater subjected to acid addition for pH control (MWW_pH); secondary treated municipal wastewater subjected to nitrification and sand filtration (MWW_NF); and secondary treated municipal wastewater subjected nitrification, sand filtration, and GAC adsorption (MWW_NFG). Tertiary treatment was determined to be essential to achieve appropriate corrosion, scaling, and biofouling control for use of secondary treated municipal wastewater in power plant cooling systems. The ability to control scaling, in particular, was found to be significantly enhanced with tertiary treated wastewater compared to secondary treated wastewater. MWW_pH treated water (adjustment to pH 7.8) was effective in reducing scale formation, but increased corrosion and the amount of biocide required to achieve appropriate biofouling control. Corrosion could be adequately controlled with tolytriazole addition (4-5 ppm TTA), however, which was the case for all of the tertiary treated waters. For MWW_NF treated water, the removal of ammonia by nitrification helped to reduce the corrosivity and biocide demand. Also, the lower pH and alkalinity resulting from nitrification reduced the scaling to an acceptable level, without the addition of anti-scalant chemicals. Additional GAC adsorption treatment, MWW_NFG, yielded no net benefit. Removal of organic matter resulted in pitting corrosion in copper and cupronickel alloys. Negligible improvement was observed in scaling control and biofouling control. For all of the tertiary treatments, biofouling control was achievable, and most effectively with pre-formed monochloramine (2-3 ppm) in comparison with NaOCl and ClO2. Life cycle cost (LCC) analyses were performed for the tertiary treatment systems studied experimentally and for several other treatment options. A public domain conceptual costing tool (LC3 model) was developed for this purpose. MWW_SF (lime softening and sand filtration) and MWW_NF were the most cost-effective treatment options among the tertiary treatment alternatives considered because of the higher effluent quality with moderate infrastructure costs and the relatively low doses of conditioning chemicals required. Life cycle inventory (LCI) analysis along with integration of external costs of emissions with direct costs was performed to evaluate relative emissions to the environment and external costs associated with construction and operation of tertiary treatment alternatives. Integrated LCI and LCC analysis indicated that three-tiered treatment alternatives such as MWW_NSF and MWW_NFG, with regular chemical addition for treatment and conditioning and/or regeneration, tend to increase the impact costs and in turn the overall costs of tertiary treatment. River water supply and MWW_F alternatives with a single step of tertiary treatment were associated with lower impact costs, but the contribution of impact costs to overall annual costs was higher than all other treatment alternatives. MWW_NF and MWW_SF alternatives exhibited moderate external impact costs with moderate infrastructure and chemical conditioner dosing, which makes them (especially

David Dzombak; Radisav Vidic; Amy Landis

2012-06-30T23:59:59.000Z

476

Surrogate measurement of the {sup 238}Pu(n,f) cross section  

Science Conference Proceedings (OSTI)

The neutron-induced fission cross section of {sup 238}Pu was determined using the surrogate ratio method. The (n,f) cross section over an equivalent neutron energy range 5-20 MeV was deduced from inelastic {alpha}-induced fission reactions on {sup 239}Pu, with {sup 235}U({alpha},{alpha}{sup '}f) and {sup 236}U({alpha},{alpha}{sup '}f) used as references. These reference reactions reflect {sup 234}U(n,f) and {sup 235}U(n,f) yields, respectively. The deduced {sup 238}Pu(n,f) cross section agrees well with standard data libraries up to {approx}10 MeV, although larger values are seen at higher energies. The difference at higher energies is less than 20%.

Ressler, J. J.; Burke, J. T.; Escher, J. E.; Bernstein, L. A.; Bleuel, D. L.; Casperson, R. J.; Gostic, J.; Henderson, R.; Scielzo, N. D.; Thompson, I. J.; Wiedeking, M. [Lawrence Livermore National Laboratory, Livermore, California 94551 (United States); Angell, C. T.; Goldblum, B. L.; Munson, J. [Department of Nuclear Engineering, University of California, Berkeley, California 94720 (United States); Basunia, M. S.; Phair, L. W. [Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Beausang, C. W.; Hughes, R. O. [Department of Physics, University of Richmond, Richmond, Virginia 23173 (United States); Hatarik, R. [Lawrence Livermore National Laboratory, Livermore, California 94551 (United States); Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Ross, T. J. [Department of Physics, University of Richmond, Richmond, Virginia 23173 (United States); Department of Physics, University of Surrey, Guildford GU2 7XH (United Kingdom)

2011-05-15T23:59:59.000Z

477

Cellular and molecular level responses after radiofrequency radiation exposure, alone or in combination with x-rays or chemicals. Final report, 1 April 1991-30 September 1994  

SciTech Connect

This project was initiated to explore the potential bioeffects of microwave radiation, alone or in combination with ionizing radiation and chemicals. Over the time period of the project, an automated thermal control system, to be used for maintaining the temperature in tissue culture medium during microwave exposures, was designed, constructed, and software was created. While this was underway during the project period, numerous positive control biological experiments were performed on two different cell types, the Epstein Barr Virus transformed 244B human lymphoblastoid cell, and the freshly isolated peripheral human lymphocyte. The 244B cells were used to address the question of whether a physical agent, ionizing radiation, at low doses where cells would predominantly remain viable, would induce the DNA binding protein NF-kB, and/or four immediate early genes (IEG) (protooncogenes).

Meltz, M.L.; Natarajan, M.; Prasad, A.V.

1995-02-21T23:59:59.000Z

478

Dissipative Cryogenic Filters with Zero DC Resistance  

SciTech Connect

The authors designed, implemented and tested cryogenic RF filters with zero DC resistance, based on wires with a superconducting core inside a resistive sheath. The superconducting core allows low frequency currents to pass with negligible dissipation. Signals above the cutoff frequency are dissipated in the resistive part due to their small skin depth. The filters consist of twisted wire pairs shielded with copper tape. Above approximately 1 GHz, the attenuation is exponential in {radical}{omega}, as typical for skin depth based RF filters. By using additional capacitors of 10 nF per line, an attenuation of at least 45 dB above 10 MHz can be obtained. Thus, one single filter stage kept at mixing chamber temperature in a dilution refrigerator is sufficient to attenuate room temperature black body radiation to levels corresponding to 10 mK above about 10 MHz.

Bluhm, Hendrik; Moler, Kathryn A.; /Stanford U., Appl. Phys. Dept

2008-04-22T23:59:59.000Z

479

Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP)  

Science Conference Proceedings (OSTI)

The human CRF-binding protein gene has been cloned and mapped to the distal region of chromosome 13 and loci 5q in the mouse and human genomes, respectively. The gene consists of 7 exons and 6 introns. The mature protein has 10 cysteines and 5 tandem disulfide bridges 4 of which are contained within exons 3, 5, 6, and 7. One bridge is shared by exons 3 and 4. The signal peptide and the first 3 amino acids of the mature protein were coded for by an extreme 5[prime] exon. Primer extension analyses revealed the transcriptional initiation site to be located 32 bp downstream from a consensus TATA box. The promoter sequence contained a number of putative promoter elements including an AP-1 site, three ER-half sites, the immunoglobulin enhancer elements NF-kB and INF-1, and the liver-specific enhancers LFA1 and LFB1. 26 refs., 5 figs., 1 tab.

Behan, D.P.; Potter, E.; Lewis, K.A.; Vale, W.W. (Salk Inst., La Jolla, CA (United States)); Jenkins, N.A.; Copeland, N. (Frederick Cancer Research and Development Center, MD (United States)); Lowry, P.J. (Reading Univ. (United Kingdom))

1993-04-01T23:59:59.000Z

480

Probing novel TeV physics through precision calculations of scalar and tensor charges of the nucleon  

E-Print Network (OSTI)

We present an update on the calculation of matrix elements of iso-vector scalar, axial and tensor charges between a neutron and a proton state. These matrix elements are needed to probe novel scalar and tensor interactions in neutron beta-decay that can arise in extensions of the Standard Model at the TeV scale. Our calculations are being done using valence clover fermions on dynamical N_f=2+1+1 HISQ configurations generated by the MILC Collaboration. We provide preliminary estimates of the dependence of these matrix elements on the light quark masses, lattice spacing, and the time separation between the source and sink of the nucleons. We also find that the renormalization constants calculated using the RI-sMOM scheme are close to unity for the HYP smeared HISQ lattices.

Rajan Gupta; Tanmoy Bhattacharya; Anosh Joseph; Saul D. Cohen; Huey-Wen Lin

2012-12-20T23:59:59.000Z

Note: This page contains sample records for the topic "nf nf nf" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Fireside corrosion testing of candidate superheater tube alloys, coatings, and claddings -- Phase 2 field testing  

SciTech Connect

In Phase 1 of this project, a variety of developmental and commercial tubing alloys and claddings was exposed to laboratory fireside corrosion testing simulating a superheater or reheater in a coal-fired boiler. Phase 2 (in situ testing) has exposed samples of 347, RA85H, HR3C, 253MA, Fe{sub 3}Al + 5Cr, 310 modified, NF 709, 690 clad, and 671 clad for over 10,000 hours to the actual operating conditions of a 250-MW coal-fired boiler. The samples were installed on air-cooled, retractable corrosion probes, installed in the reheater cavity, controlled to the operating metal temperatures of an existing and advanced-cycle, coal-fired boiler. Samples of each alloy are being exposed for 4,000, 12,000, and 16,000 hours of operation. The present results are for the metallurgical examination of the corrosion probe samples after approximately 4,400 hours of exposure.

Blough, J.L. [Foster Wheeler Development Corp., Livingston, NJ (United States)

1996-08-01T23:59:59.000Z

482

Opening the Rome-Southampton window for operator mixing matrices  

E-Print Network (OSTI)

We show that the running of operators which mix under renormalization can be computed fully non-perturbatively as a product of continuum step scaling matrices. These step scaling matrices are obtained by taking the "ratio" of Z matrices computed at different energies in an RI-MOM type scheme for which twisted boundary conditions are an essential ingredient. Our method allows us to relax the bounds of the Rome-Southampton window. We also explain why such a method is important in view of the light quark physics program of the RBC-UKQCD collaborations. To illustrate our method, using n_f=2+1 domain-wall fermions, we compute the non-perturbative running matrix of four-quark operators needed in K->pipi decay and neutral kaon mixing. Our results are then compared to perturbation theory.

R. Arthur; P. A. Boyle; N. Garron; C. Kelly; A. T. Lytle

2011-09-06T23:59:59.000Z

483

SULFUR HEXAFLUORIDE TREATMENT OF USED NUCLEAR FUEL TO ENHANCE SEPARATIONS  

SciTech Connect

Reactive Gas Recycling (RGR) technology development has been initiated at Savannah River National Laboratory (SRNL), with a stretch-goal to develop a fully dry recycling technology for Used Nuclear Fuel (UNF). This approach is attractive due to the potential of targeted gas-phase treatment steps to reduce footprint and secondary waste volumes associated with separations relying primarily on traditional technologies, so long as the fluorinators employed in the reaction are recycled for use in the reactors or are optimized for conversion of fluorinator reactant. The developed fluorination via SF{sub 6}, similar to the case for other fluorinators such as NF{sub 3}, can be used to address multiple fuel forms and downstream cycles including continued processing for LWR via fluorination or incorporation into a aqueous process (e.g. modified FLUOREX) or for subsequent pyro treatment to be used in advanced gas reactor designs such metal- or gas-cooled reactors. This report details the most recent experimental results on the reaction of SF{sub 6} with various fission product surrogate materials in the form of oxides and metals, including uranium oxides using a high-temperature DTA apparatus capable of temperatures in excess of 1000{deg}C . The experimental results indicate that the majority of the fission products form stable solid fluorides and sulfides, while a subset of the fission products form volatile fluorides such as molybdenum fluoride and niobium fluoride, as predicted thermodynamically. Additional kinetic analysis has been performed on additional fission products. A key result is the verification that SF{sub 6} requires high temperatures for direct fluorination and subsequent volatilization of uranium oxides to UF{sub 6}, and thus is well positioned as a head-end treatment for other separations technologies, such as the volatilization of uranium oxide by NF{sub 3} as reported by colleagues at PNNL, advanced pyrochemical separations or traditional full recycle approaches. Based on current results of the research at SRNL on SF{sub 6} fluoride volatility for UNF separations, SF{sub 6} treatment renders all anticipated volatile fluorides studied to be volatile, and all non-volatile fluorides studied to be non-volatile, with the notable exception of uranium oxides. This offers an excellent opportunity to use this as a head-end separations treatment process because: 1. SF{sub 6} can be used to remove volatile fluorides from a UNF matrix while leaving behind uranium oxides. Therefore an agent such as NF{sub 3} should be able to very cleanly separate a pure UF{sub 6} stream, leaving compounds in the bottoms such as PuF{sub 4}, SrF{sub 2} and CsF after the UNF matrix has been pre-treated with SF{sub 6}. 2. Due to the fact that the uranium oxide is not separated in the volatilization step upon direct contact with SF{sub 6} at moderately high temperatures (? 1000{deg}C), this fluoride approach may be wellsuited for head-end processing for Gen IV reactor designs where the LWR is treated as a fuel stock, and it is not desired to separate the uranium from plutonium, but it is desired to separate many of the volatile fission products. 3. It is likely that removal of the volatile fission products from the uranium oxide should simplify both traditional and next generation pyroprocessing techniques. 4. SF{sub 6} treatment to remove volatile fission products, with or without treatment with additional fluorinators, could be used to simplify the separations of traditional aqueous processes in similar fashion to the FLUOREX process. Further research should be conducted to determine the separations efficiency of a combined SF{sub 6}/NF{sub 3} separations approach which could be used as a stand-alone separations technology or a head-end process.

Gray, J.; Torres, R.; Korinko, P.; Martinez-Rodriguez, M.; Becnel, J.; Garcia-Diaz, B.; Adams, T.

2012-09-25T23:59:59.000Z

484

System for studying a sample of material using a heavy ion induced mass spectrometer source  

DOE Patents (OSTI)

A heavy ion generator is used with a plasma desorption mass spectrometer to provide an appropriate neutron flux in the direction of a fissionable material in order to desorb and ionize large molecules from the material for mass analysis. The heavy ion generator comprises a fissionable material having a high (n,f) reaction cross section. The heavy ion generator also comprises a pulsed neutron generator that is used to bombard the fissionable material with pulses of neutrons, thereby causing heavy ions to be emitted from the fissionable material. These heavy ions impinge on a material, thereby causing ions to desorb off that material. The ions desorbed off the material pass through a time-of-flight mass analyzer, wherein ions can be measured with masses greater than 25,000 amu. 3 figs.

Fries, D.P.; Browning, J.F.

1998-07-21T23:59:59.000Z

485

System for studying a sample of material using a heavy ion induced mass spectrometer source  

DOE Patents (OSTI)

A heavy ion generator is used with a plasma desorption mass spectrometer to provide an appropriate neutron flux in the direction of a fissionable material in order to desorb and ionize large molecules from the material for mass analysis. The heavy ion generator comprises a fissionable material having a high n,f reaction cross section. The heavy ion generator also comprises a pulsed neutron generator that is used to bombard the fissionable material with pulses of neutrons, thereby causing heavy ions to be emitted from the fissionable material. These heavy ions impinge on a material, thereby causing ions to desorb off that material. The ions desorbed off the material pass through a time-of-flight mass analyzer, wherein ions can be measured with masses greater than 25,000 amu.

Fries, David P. (St. Petersburg, FL); Browning, James F. (Palm Harbour, FL)

1998-01-01T23:59:59.000Z

486

Method for studying a sample of material using a heavy ion induced mass spectrometer source  

DOE Patents (OSTI)

A heavy ion generator is used with a plasma desorption mass spectrometer to provide an appropriate neutron flux in the direction of a fissionable material in order to desorb and ionize large molecules from the material for mass analysis. The heavy ion generator comprises a fissionable material having a high n,f reaction cross section. The heavy ion generator also comprises a pulsed neutron generator that is used to bombard the fissionable material with pulses of neutrons, thereby causing heavy ions to be emitted from the fissionable material. These heavy ions impinge on a material, thereby causing ions to desorb off that material. The ions desorbed off the material pass through a time-of-flight mass analyzer, wherein ions can be measured with masses greater than 25,000 amu.

Fries, David P. (St. Petersburg, FL); Browning, James F. (Palm Harbour, FL)

1999-01-01T23:59:59.000Z

487

Method for studying a sample of material using a heavy ion induced mass spectrometer source  

DOE Patents (OSTI)

A heavy ion generator is used with a plasma desorption mass spectrometer to provide an appropriate neutron flux in the direction of a fissionable material in order to desorb and ionize large molecules from the material for mass analysis. The heavy ion generator comprises a fissionable material having a high n,f reaction cross section. The heavy ion generator also comprises a pulsed neutron generator that is used to bombard the fissionable material with pulses of neutrons, thereby causing heavy ions to be emitted from the fissionable material. These heavy ions impinge on a material, thereby causing ions to desorb off that material. The ions desorbed off the material pass through a time-of-flight mass analyzer, wherein ions can be measured with masses greater than 25,000 amu. 3 figs.

Fries, D.P.; Browning, J.F.

1999-02-16T23:59:59.000Z

488

Performance of aluminide coatings applied on alloy CF8C plus at 800 C  

Science Conference Proceedings (OSTI)

The cost effective, austenitic stainless steel CF8C plus is an attractive alloy for massive cast structures such as steam turbine casings. The microstructure stability and creep strength of this alloy are better than commercial high-performance heat-resistant steels such as NF709 and Super 304H, and are comparable to the Ni-based superalloy Inconel 617. The oxidation resistance of the alloy in atmosphere rich in water vapor is however insufficient at T>800 C, and the use of diffusion aluminide coatings is considered for potential high temperature applications. The thermal stability and protectiveness of coatings applied on the CF8C plus substrate by pack cementation and slurry process were investigated in air + 10% H2O environment at 800 C. Further, the coating effect on the fatigue life of the alloy was assessed via low-cycle-fatigue experiments.

Kumar, Deepak [ORNL; Dryepondt, Sebastien N [ORNL; Shyam, Amit [ORNL; Haynes, James A [ORNL; Pint, Bruce A [ORNL; Armstrong, Beth L [ORNL; Lara-Curzio, Edgar [ORNL

2011-01-01T23:59:59.000Z

489

Probing TeV scale physics via ultra cold neutron decays and calculating non-standard baryon matrix elements  

E-Print Network (OSTI)

We motivate undertaking precision analyses of neutron decays to look for signatures of new scalar and tensor interactions that can arise in extensions of the Standard Model at the TeV scale. The key ingrediant needed to connect experimental data with theoretical analysis are high-precision calculations of matrix elements of isovector bilinear operators between the decaying neutron and final state proton. We describe the status of our Lattice QCD program of using valence clover fermions on dynamical N_f=2+1+1 HISQ configurations generated by the MILC Collaboration. On the theoretical side we use the effective field theory method and provide both model independent and dependent analyses to obtain bounds on possible scalar and tensor interactions, both from low energy experiments and LHC data.

Rajan Gupta; Tanmoy Bhattacharya; Anosh Joseph; Huey-Wen Lin; Saul D. Cohen

2012-02-07T23:59:59.000Z

490

The quark contents of the nucleon and their implication for dark matter search  

E-Print Network (OSTI)

We present results concerning the light and strange quark contents of the nucleon using $N_f=2+1+1$ flavours of maximally twisted mass fermions. The corresponding $\\sigma$-terms are casting light on the origin of the nucleon mass and their values are important to interpret experimental data from direct dark matter searches. We discuss our strategy to estimate systematic uncertainties arising in our computations. Our preliminary results for the $\\sigma-$terms read $\\sigma_{\\pi N} = 37(2.6)(24.7) \\mev$ and $\\sigma_s=28(8)(10) \\mev$. We present our recent final analysis of the $y_N$ parameter and found $y_N=0.135(46)$ including systematics\\cite{Alexandrou:2013nda}.

C. Alexandrou; M. Constantinou; V. Drach; K. Hadjiyiannakou; K. Jansen; G. Koutsou; A. Strelchenko; A. Vaquero

2013-11-24T23:59:59.000Z

491

Scattering in the pion-nucleon negative parity channel in lattice QCD  

E-Print Network (OSTI)

We study the coupled pion-nucleon system (negative parity, isospin 1/2) based on a lattice QCD simulation for nf=2 mass degenerate light quarks. Both, standard 3-quarks baryon operators as well as meson-baryon (4+1)-quark operators are included. This is an exploratory study for just one lattice size and lattice spacing and at a pion mass of 266 MeV. Using the distillation method and variational analysis we determine energy levels of the lowest eigenstates. Comparison with the results of simple 3-quark correlation studies exhibits drastic differences and a new level appears. A clearer picture of the negative parity nucleon spectrum emerges. For the parameters of the simulation we may assume elastic s-wave scattering and can derive values of the phase shift.

C. B. Lang; V. Verduci

2012-12-20T23:59:59.000Z

492

Scattering in the pion-nucleon negative parity channel in lattice QCD  

E-Print Network (OSTI)

We study the coupled pion-nucleon system (negative parity, isospin 1/2) based on a lattice QCD simulation for nf=2 mass degenerate light quarks. Both, standard 3-quarks baryon operators as well as meson-baryon (4+1)-quark operators are included. This is an exploratory study for just one lattice size and lattice spacing and at a pion mass of 266 MeV. Using the distillation method and variational analysis we determine energy levels of the lowest eigenstates. Comparison with the results of simple 3-quark correlation studies exhibits drastic differences and a new level appears. A clearer picture of the negative parity nucleon spectrum emerges. For the parameters of the simulation we may assume elastic s-wave scattering and can derive values of the phase shift.

Lang, C B

2013-01-01T23:59:59.000Z

493

U.S. DEPARThIENT OF ENERGY EERE PROJECT MANAGEMENT CENTER NEPA DETERMINATION  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

:. :. U.S. DEPARThIENT OF ENERGY EERE PROJECT MANAGEMENT CENTER NEPA DETERMINATION RECIPIENT:Kansas Corporation Commission PROJECT TITLE: Multi-Family Housing Weatherizallon Page \ of2 STATE: KS Funding Opponunlty Announcement Number DE-FOA-OOOOO52 Procurement Instrument Number NF.PA Control Number CID Number DE-EEOOOOO132 GF0-0000132-006 0 Based on my review oflhe information concuning the proposed action, as NEPA Compliance Officer (aulhori7.ed under DOE Order 4SI.IA), I bave made the (allowing determination: ex, EA, EIS APPENDIX AND NUMBER: Description: 85.1 Action s 10 conserve energy, demonstrate potential energy conservation , and promote energy-efficiency that do not increase the indoor ooncenlrallQns of potentially harmful substances. These actions may involve financial and technical

494

S:\VM3\RX97\TBL_LIST.WPD [PFP#201331587]  

U.S. Energy Information Administration (EIA) Indexed Site

Million U.S. Households, 1997 Usage Indicators RSE Column Factor: Total Four Most Populated States RSE Row Factors New York California Texas Florida 0.4 1.2 1.1 1.3 1.5 Total .............................................................. 101.5 6.8 11.5 7.0 5.9 NF Weekday Home Activities Home Used for Business Yes ............................................................ 7.4 0.5 0.9 0.4 0.4 13.5 No .............................................................. 94.1 6.3 10.6 6.5 5.6 2.2 Energy-Intensive Activity Yes ............................................................ 2.4 Q 0.4 0.1 Q 26.0 No .............................................................. 99.1 6.7 11.1 6.8 5.8 1.5 Someone Home All Day Yes ............................................................

495

table5.3_02  

U.S. Energy Information Administration (EIA) Indexed Site

3 End Uses of Fuel Consumption, 2002; 3 End Uses of Fuel Consumption, 2002; Level: National Data; Row: End Uses within NAICS Codes; Column: Energy Sources, including Net Demand for Electricity; Unit: Physical Units or Btu. Distillate Net Demand Fuel Oil Coal for Residual and Natural LPG and (excluding Coal RSE NAICS Electricity(b) Fuel Oil Diesel Fuel(c) Gas(d) NGL(e) Coke and Breeze) Row Code(a) End Use (million kWh) (million bbl) (million bbl) (billion cu ft) (million bbl) (million short tons) Factors Total United States 311 - 339 ALL MANUFACTURING INDUSTRIES RSE Column Factors: NF 1 2.4 1.1 1.4 1 TOTAL FUEL CONSUMPTION 966,231 33 24 5,641 26 53 3.4 Indirect Uses-Boiler Fuel 6,714 20 6 2,105 2 35 5.3 Conventional Boiler Use

496

Light Meson Distribution Amplitudes  

E-Print Network (OSTI)

We calculated the first two moments of the light-cone distribution amplitudes for the pseudoscalar mesons ($\\pi$ and $K$) and the longitudinally polarised vector mesons ($\\rho$, $K^*$ and $\\phi$) as part of the UKQCD and RBC collaborations' $N_f=2+1$ domain-wall fermion phenomenology programme. These quantities were obtained with a good precision and, in particular, the expected effects of $SU(3)$-flavour symmetry breaking were observed. Operators were renormalised non-perturbatively and extrapolations to the physical point were made, guided by leading order chiral perturbation theory. The main results presented are for two volumes, $16^3\\times 32$ and $24^3\\times 64$, with a common lattice spacing. Preliminary results for a lattice with a finer lattice spacing, $32^3\\times64$, are discussed and a first look is taken at the use of twisted boundary conditions to extract distribution amplitudes.

R. Arthur; P. A. Boyle; D. Brmmel; M. A. Donnellan; J. M. Flynn; A. Jttner; H. Pedroso de Lima; T. D. Rae; C. T. Sachrajda; B. Samways

2010-11-12T23:59:59.000Z

497

Study of Scheme Transformations to Remove Higher-Loop Terms in the $?$ Function of a Gauge Theory  

E-Print Network (OSTI)

Since three-loop and higher-loop terms in the $\\beta$ function of a gauge theory are scheme-dependent, one can, at least for sufficiently small coupling, carry out a scheme transformation that removes these terms. A basic question concerns the extent to which this can be done at an infrared fixed point of an asymptotically free gauge theory. This is important for quantitative analyses of the scheme dependence of such a fixed point. Here we study a scheme transformation $S_{R,m}$ with $m \\ge 2$ that is constructed so as to remove the terms in the beta function at loop order $\\ell=3$ to $\\ell=m+1$, inclusive. Starting from an arbitrary initial scheme, we present general expressions for the coefficients of terms of loop order $\\ell$ in the beta function in the transformed scheme from $\\ell=m+2$ up to $\\ell=8$. Extending a previous study of $S_{R,2}$, we investigate the range of applicability of the $S_{R,3}$ scheme transformation in an asymptotically free SU($N_c$) gauge theory with an infrared zero in $\\beta$ depending on the number, $N_f$, of fermions in the theory. We show that this $S_{R,3}$ scheme transformation can only be applied self-consistently in a restricted range of $N_f$ with a correspondingly small value of infrared fixed-point coupling. We also study the effect of higher-loop terms on the beta function of a U(1) gauge theory.

Robert Shrock

2013-05-28T23:59:59.000Z

498

Neutrino-electron scattering in a magnetic field with allowance for polarizations of electrons  

Science Conference Proceedings (OSTI)

We present an analytic formula for differential cross section (DCS) of neutrino-electron scattering (NES) in a magnetic field (MF) with allowance for longitudinal polarizations of initial and final electrons (IAFE). The DCS of NES in a MF is sensitive to the spin variable of the IAFE and to the direction of the incident and scattered neutrinos (IASN) momenta. Spin asymmetries and field effects in NES in a MF enable us to use initial electrons having a left-hand circular polarization (LHCP) as polarized electron targets in detectors for detection of low-energy neutrinos or relic neutrinos and for distinguishing neutrino flavor (NF). In general, gas consisting of only electrons having a LHCP and gas consisting of only electrons having a right-hand circular polarization (RHCP) are heated by neutrinos asymmetrically. The asymmetry of heating (AH) is sensitive to NF, MF strength, energies (Landau quantum numbers and third components of the momenta) of IAFE, final electron chemical potential, the final temperature of gas consisting of only electrons having a LHCP (RHCP), polar angles of IASN momenta, the difference between the azimuthal angles of IASN momenta, the angle {phi}, and IASN energies. In the heating process of electrons by neutrinos the dominant role belongs to electron neutrinos compared with the contribution of muon (tauon) neutrinos. Electrons having a LHCP in NES in a MF are heated by {nu}{sub e} and {nu}{sub {mu}}({nu}{sub {tau}}) unequally when both the IASN fly along or against the MF direction. For magnetars and neutrinos of 1 MeV energy, within the considered kinematics, the AH in an electron neutrino-electron scattering is 2.23 times that in a muon neutrino-electron scattering or in a tauon neutrino-electron scattering.

Guseinov, V. A. [Department of General and Theoretical Physics, Nakhchivan State University, AZ 7000, Nakhchivan (Azerbaijan); Laboratory of Physical Research, Nakhchivan Division of Azerbaijan National Academy of Sciences, AZ 7000, Nakhchivan (Azerbaijan); Jafarov, I. G. [Department of Theoretical Physics and Astrophysics, Azerbaijan State Pedagogical University, Baku (Azerbaijan); Gasimova, R. E. [Department of General and Theoretical Physics, Nakhchivan State University, AZ 7000, Nakhchivan (Azerbaijan)

2007-04-01T23:59:59.000Z

499

Induction of Genomic Instability In Vivo by Low Doses of 137Cs gamma rays  

SciTech Connect

The overall goal of this project is to determine if low doses (below or equal to the level traditionally requiring human radiation protection, i.e. less than or equal to 10 cGy) of low LET radiation can induce genomic instability. The magnitude of genomic instability was measured as delayed chromosome instability in bone marrow cells of exposed mice with different levels of endogenous DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity, i.e. high (C57BL/6J mice), intermediate (BALB/cJ mice), and extremely low (Scid mice). In addition, at early time points (1 and 4 hrs) following irradiation, levels of activation of nuclear factor-kappa B (NF-{kappa}B), a transcription factor known to be involved in regulating the expression of genes responsible for cell protection following stimuli, were measured in these cells. Bone marrow cells were collected at different times following irradiation, i.e. 1 hr, 4 hrs, 1 month, and 6 months. A total of five mice per dose per strain were sacrificed at each time point for sample collection. As a result, a total of 80 mice from each strain were used. The frequency and the type of metaphase chromosome aberrations in bone marrow cells collected from exposed mice at different times following irradiation were used as markers for radiation-induced genomic instability. A three-color fluorescence in situ hybridization (FISH) protocol for mouse chromosomes 1, 2, and 3 was used for the analysis of delayed stable chromosomal aberrations in metaphase cells. All other visible chromatid-type aberrations and gross structural abnormalities involving non-painted chromosomes were also evaluated on the same metaphase cells used for scoring the stable chromosomal aberrations of painted chromosomes. Levels of nuclear factor-kappa B (NF-{kappa}B) activation were also determined in cells at 1 and 4 hrs following irradiation (indicative of early responses).

Rithidech, Kanokporn; Simon, Sanford, R.; Whorton, Elbert, B.

2006-01-06T23:59:59.000Z

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Dissection of the erythroid-specific transcriptional promoter used by the gene encoding aminolevulinic acid dehydratase (ALAD)  

Science Conference Proceedings (OSTI)

The gene encoding delta-aminolevulinate dehydratase (ALAD), the second enzyme of the heme biosynthetic pathway, exists as a single gene in most mammalian genomes and we have sequenced over 12 kb from overlapping lambda clones containing the murine ALAD gene. The gene has a dual promoter driving expression of two different first exons; exon1A is expressed in all tissues and exon1B only in erythroid cells, where heme production is induced to exceptionally high levels for hemoglobin synthesis. Erythroid-specific expression of the ALAD gene is presumably accomplished by using the exon1B promoter which we hypothesize is responsive to erythroid-specific transcriptional activators. In order to test this, we have used gel mobility shift assays and DNase footprint analyses to dissect and identify the critical upstream regulatory elements. Nuclear extracts, prepared from murine erythroleukemia cells (MELC), human chronic myelogenous leukemia cell line (K562) and human fibroblast cell line (HeLa), were used as sources of proteins to analyze DNA binding sites in the ALAD erythroid-specific promoter from -307 to +1. In this region, there are three potential GATA1 sites, two CACCC boxes, a CCAAT box and a GGTGG box. NF-E2 sites were explored by using in vitro translation products of cloned p18 and p45, the two heterologous components of NF-E2, and successfully gel-shifted a 29 bp double-stranded oligo found at 2.6 kb in front of the ALAD gene. Thus, the ALAD gene utilizes both a housekeeping and a tissue-specific promoter.

Bishop, T.R.; Schaffer, T.; Pien, B. [Johns Hopkins Univ. School of Medicine, Baltimore, MD (United States)

1994-09-01T23:59:59.000Z