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Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
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1

Metropolitan Edison Co (Pennsylvania) | Open Energy Information  

Open Energy Info (EERE)

Pennsylvania) Jump to: navigation, search Name Metropolitan Edison Co Place Pennsylvania Utility Id 12390 References EIA Form EIA-861 Final Data File for 2010 - File220101...

2

Alternative Fuels Data Center: Metropolitan Utilities District Fuels  

Alternative Fuels and Advanced Vehicles Data Center (EERE)

Metropolitan Utilities Metropolitan Utilities District Fuels Vehicles With Natural Gas to someone by E-mail Share Alternative Fuels Data Center: Metropolitan Utilities District Fuels Vehicles With Natural Gas on Facebook Tweet about Alternative Fuels Data Center: Metropolitan Utilities District Fuels Vehicles With Natural Gas on Twitter Bookmark Alternative Fuels Data Center: Metropolitan Utilities District Fuels Vehicles With Natural Gas on Google Bookmark Alternative Fuels Data Center: Metropolitan Utilities District Fuels Vehicles With Natural Gas on Delicious Rank Alternative Fuels Data Center: Metropolitan Utilities District Fuels Vehicles With Natural Gas on Digg Find More places to share Alternative Fuels Data Center: Metropolitan Utilities District Fuels Vehicles With Natural Gas on

3

New York Metropolitan Transportation Council  

E-Print Network (OSTI)

The contents of this report reflect the views of those interviewed as interpreted by the authors except where specified. The authors are responsible for the facts, data, and analyses presented herein. The contents do not necessarily reflect the official views or policies of the Federal Highway Administration, the Federal Transit Administration, nor the collective membership of the New York Metropolitan Transportation Council (NYMTC). This report does not constitute a standard, specification, or regulation. Acceptance of this report as evidence of fulfillment, in part or whole, of the objectives of the planning study PTCS.07.P12 does not constitute endorsement or approval of the need for any recommended improvement or additional study. It is being sponsored by the NYMTC for the benefit of its members and all interested stakeholders. Other legislation, regulation, executive order(s), official policy, and/or standard practice may supersede the recommendations or advice provided within. 1. Report No.

Jeff Ban Ph. D; Miguel Jaller M. S; Lisa Destro; Robyn Marquis

2010-01-01T23:59:59.000Z

4

The Geography of Metropolitan Carbon Footprints  

SciTech Connect

The world s metropolitan carbon footprints have distinct geographies that are not well understood or recognized in debates about climate change, partly because data on greenhouse gas emissions is so inadequate. This article describes the results of the most comprehensive assessment of carbon footprints for major American metropolitan areasavailable to date, focusing on residential and transportation carbon emissions for the largest 100 metropolitan areas in the United States. These findings are put into the context of effortsacross the country and the globe to characterize carbon impacts and policy linkages.

Brown, Dr. Marilyn Ann [Georgia Institute of Technology; Southworth, Frank [ORNL; Sarzynski, Andrea [Brookings Institution

2009-01-01T23:59:59.000Z

5

Metropolitan Edison Co | Open Energy Information  

Open Energy Info (EERE)

Metropolitan Edison Co Metropolitan Edison Co Jump to: navigation, search Name Metropolitan Edison Co Place Ohio Utility Id 12390 Utility Location Yes Ownership I NERC Location RFC NERC RFC Yes RTO PJM Yes Activity Transmission Yes Activity Buying Transmission Yes Activity Distribution Yes Activity Wholesale Marketing Yes Alt Fuel Vehicle Yes Alt Fuel Vehicle2 Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] Energy Information Administration Form 826[2] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png RS Residential RT (Time-Of-Day) Residential Average Rates No Rates Available The following table contains monthly sales and revenue data for

6

Metropolitan Groundwater Plans (Minnesota) | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Groundwater Plans (Minnesota) Groundwater Plans (Minnesota) Metropolitan Groundwater Plans (Minnesota) < Back Eligibility Utility Fed. Government Commercial Agricultural Investor-Owned Utility State/Provincial Govt Industrial Construction Municipal/Public Utility Local Government Residential Installer/Contractor Rural Electric Cooperative Tribal Government Low-Income Residential Schools Retail Supplier Institutional Multi-Family Residential Systems Integrator Fuel Distributor Nonprofit General Public/Consumer Transportation Savings Category Alternative Fuel Vehicles Hydrogen & Fuel Cells Buying & Making Electricity Water Home Weatherization Solar Wind Program Info State Minnesota Program Type Environmental Regulations This section gives metropolitan counties the authority to prepare and adopt groundwater plans, or to grant this responsibility to soil and water

7

Human mobility modeling at metropolitan scales  

Science Conference Proceedings (OSTI)

Models of human mobility have broad applicability in fields such as mobile computing, urban planning, and ecology. This paper proposes and evaluates WHERE, a novel approach to modeling how large populations move within different metropolitan areas. ... Keywords: call detail records, human mobility patterns

Sibren Isaacman; Richard Becker; Ramón Cáceres; Margaret Martonosi; James Rowland; Alexander Varshavsky; Walter Willinger

2012-06-01T23:59:59.000Z

8

Metropolitan functional specialization, transportation, and gasoline consumption  

SciTech Connect

This study examines metropolitan functional specialization relative to urban commuting patterns and per capita gasoline consumption in 55 Standard Metropolitan Statistical Areas throughout the United States. Under the concept of sustenance organization in human ecology, social scientists have documented support for the importance of the key urban economic function for composition and distribution of population and firms in cities. However, sociological and ecological knowledge of the relationships of functional specialization, commuting, and transportation energy use is extremely limited. The present research utilizes the concept of function specialization and the framework of the ecological complex in developing relationships and models of personal daily urban travel patterns and gasoline use. The effort is made to examine human ecological factors in a physical approach to energy consumption. Relationships are tested using correlation matrices, regression analyses, and scatterplots where necessary. The findings indicate that the functional specialization of communities is significant in accounting for variance and patterns in their commuting travel and per capita gasoline consumption.

Hoffman, W.D.

1985-01-01T23:59:59.000Z

9

Los Angeles County Metropolitan Transportation Authority Metro | Open  

Open Energy Info (EERE)

County Metropolitan Transportation Authority Metro County Metropolitan Transportation Authority Metro Jump to: navigation, search Name Los Angeles County Metropolitan Transportation Authority (Metro) Place Los Angeles, California Zip 90012-2952 Sector Renewable Energy Product Metro is the regional transportation planner for all of Los Angeles County. It is a developer of renewable energy projects. References Los Angeles County Metropolitan Transportation Authority (Metro)[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Los Angeles County Metropolitan Transportation Authority (Metro) is a company located in Los Angeles, California . References ↑ "Los Angeles County Metropolitan Transportation Authority

10

The Metropolitan Surface Water Management Act (Minnesota) | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

The Metropolitan Surface Water Management Act (Minnesota) The Metropolitan Surface Water Management Act (Minnesota) The Metropolitan Surface Water Management Act (Minnesota) < Back Eligibility Utility Fed. Government Commercial Agricultural Investor-Owned Utility State/Provincial Govt Industrial Construction Municipal/Public Utility Local Government Residential Installer/Contractor Rural Electric Cooperative Tribal Government Low-Income Residential Schools Retail Supplier Institutional Multi-Family Residential Systems Integrator Fuel Distributor Nonprofit General Public/Consumer Transportation Savings Category Alternative Fuel Vehicles Hydrogen & Fuel Cells Buying & Making Electricity Water Home Weatherization Solar Wind Program Info State Minnesota Program Type Siting and Permitting The Metropolitan Surface Water Management Act aims to protect, preserve,

11

Sustainable Energy Fund (Metropolitan Edison) | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Sustainable Energy Fund (Metropolitan Edison) Sustainable Energy Fund (Metropolitan Edison) Sustainable Energy Fund (Metropolitan Edison) < Back Eligibility Commercial Industrial Local Government Nonprofit Schools Savings Category Bioenergy Commercial Heating & Cooling Manufacturing Buying & Making Electricity Alternative Fuel Vehicles Hydrogen & Fuel Cells Water Heating & Cooling Solar Heating Water Heating Wind Maximum Rebate Varies; $25,000 for some types of projects Program Info State Pennsylvania Program Type Local Grant Program Rebate Amount Varies according to project Provider Community Foundation of the Alleghenies FirstEnergy (formerly GPU) established the Metropolitan Edison Company Sustainable Energy Fund and the Penelec Sustainable Energy Fund in 2000. The Community Foundation for the Alleghenies in Johnstown, Pennsylvania

12

The REMOTE SENSlNf  

Office of Legacy Management (LM)

REMOTE REMOTE SENSlNf ' . 1 ARllRllRRv OF THE UNITED STATES DEPARTMENT OF ENERGY . . . . .a. * ~~&hrEAWWMms Gap ~~&hrEAwwMms Gap ECT FOLLdW-UP REPORT ECT FOLLdW-UP REPORT NOVEMBER 1979 NOVEMBER 1979 AN AERIAL RADIOLOGICAL SURVEY OF THE CURTIS BAY FACILITY OF THE W. FL GRACE COMPANY Baltimore, Maryland t. Kent Hilton Project Scientist APPROVED FORPUBLlCATlON ' : T. P. Stuart, Manager Remote Sensing Sciences Department ATTACHMENT 4- ECT Follow-Up Report AN AERIAL RADIOLOGICAL SURVEY OF THE CURTIS BAY FACILITY This is the second of two reports discussing the gamma ray radiation levels measured at the Curtis Bay facility of the W. R. Grace Company. The first report presented gross count contours and gamma ray spectra over the most active areas. Refined gross count isopleth maps will be

13

Metropolitan Land Use Planning (Minnesota) | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Land Use Planning (Minnesota) Land Use Planning (Minnesota) Metropolitan Land Use Planning (Minnesota) < Back Eligibility Utility Fed. Government Commercial Agricultural Investor-Owned Utility State/Provincial Govt Industrial Construction Municipal/Public Utility Local Government Residential Installer/Contractor Rural Electric Cooperative Tribal Government Low-Income Residential Schools Retail Supplier Institutional Multi-Family Residential Systems Integrator Fuel Distributor Nonprofit General Public/Consumer Transportation Savings Category Alternative Fuel Vehicles Hydrogen & Fuel Cells Buying & Making Electricity Water Home Weatherization Solar Wind Program Info State Minnesota Program Type Environmental Regulations This statute establishes the Metropolitan Land Use Advisory Committee within the Metropolitan Council to coordinate plans, programs, and controls

14

Metropolitan Edison Company SEF Grants (FirstEnergy Territory) | Department  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Metropolitan Edison Company SEF Grants (FirstEnergy Territory) Metropolitan Edison Company SEF Grants (FirstEnergy Territory) Metropolitan Edison Company SEF Grants (FirstEnergy Territory) < Back Eligibility Commercial Industrial Local Government Nonprofit Schools Savings Category Bioenergy Commercial Heating & Cooling Manufacturing Buying & Making Electricity Alternative Fuel Vehicles Hydrogen & Fuel Cells Water Heating & Cooling Solar Heating Water Heating Wind Maximum Rebate Varies; $25,000 for some types of projects Program Info State Pennsylvania Program Type Local Grant Program Rebate Amount Varies according to project Provider Berks County Community Foundation FirstEnergy (formerly GPU) established the Metropolitan Edison Company Sustainable Energy Fund in 2000 with an initial contribution of $5.7 million. The fund later received an additional contribution of $2.5 million

15

Metropolitan Edison Company SEF Loans (FirstEnergy Territory) | Department  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Metropolitan Edison Company SEF Loans (FirstEnergy Territory) Metropolitan Edison Company SEF Loans (FirstEnergy Territory) Metropolitan Edison Company SEF Loans (FirstEnergy Territory) < Back Eligibility Commercial Industrial Local Government Nonprofit Schools Savings Category Bioenergy Commercial Heating & Cooling Manufacturing Buying & Making Electricity Alternative Fuel Vehicles Hydrogen & Fuel Cells Water Heating & Cooling Solar Heating Water Heating Wind Maximum Rebate $500,000 (generally) Program Info State Pennsylvania Program Type Local Loan Program Rebate Amount Varies according to project Provider Berks County Community Foundation FirstEnergy (formerly GPU) established the Metropolitan Edison Company Sustainable Energy Fund in 2000 with an initial contribution of $5.7 million. The fund later received an additional contribution of $2.5 million

16

The interests of landowners on the metropolitan fringe  

E-Print Network (OSTI)

Numerous authors have noted that the patchy, sprawling pattern of development characterizing the metropolitan fringe results in part from the decisions of individual landowners regarding the use, subdivision, development, ...

Molinsky, Jennifer H. (Jennifer Hrabchak)

2005-01-01T23:59:59.000Z

17

Office rent and labor availability in the Chicago Metropolitan Area  

E-Print Network (OSTI)

This paper provides an empirical analysis of office rents using data from the 2000 U.S. Census and TWR office building data in the Chicago Metropolitan Statistical Area. The results indicate that rent levels respond to ...

Tang, Wencan, M.C.P. Massachusetts Institute of Technology

2008-01-01T23:59:59.000Z

18

Metropolitan Water District of S CA | Open Energy Information  

Open Energy Info (EERE)

Water District of S CA Jump to: navigation, search Name Metropolitan Water District of S CA Place California Utility Id 12397 Utility Location Yes Ownership S NERC Location WECC...

19

Metropolitan area network support at Fermilab  

Science Conference Proceedings (OSTI)

Advances in wide area network service offerings, coupled with comparable developments in local area network technology have enabled many research sites to keep their offsite network bandwidth ahead of demand. For most sites, the more difficult and costly aspect of increasing wide area network capacity is the local loop, which connects the facility LAN to the wide area service provider(s). Fermilab, in coordination with neighboring Argonne National Laboratory, has chosen to provide its own local loop access through leasing of dark fiber to nearby network exchange points, and procuring dense wave division multiplexing (DWDM) equipment to provide data channels across those fibers. Installing and managing such optical network infrastructure has broadened the Laboratory's network support responsibilities to include operating network equipment that is located off-site, and is technically much different than classic LAN network equipment. Effectively, the Laboratory has assumed the role of a local service provider. This paper will cover Fermilab's experiences with deploying and supporting a Metropolitan Area Network (MAN) infrastructure to satisfy its offsite networking needs. The benefits and drawbacks of providing and supporting such a service will be discussed.

DeMar, Phil; Andrews, Chuck; Bobyshev, Andrey; Crawford, Matt; Colon, Orlando; Fry, Steve; Grigaliunas, Vyto; Lamore, Donna; Petravick, Don; /Fermilab

2007-09-01T23:59:59.000Z

20

Sustainable metropolitan growth strategies : exploring the role of the built environment  

E-Print Network (OSTI)

The sustainability of metropolitan areas has been considered one of the most significant social challenges worldwide. Among the various policy options to achieve sustainable metropolitan growth, smart-growth strategies ...

Diao, Mi, Ph. D. Massachusetts Institute of Technology

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Molecular Cell XIAP Induces NF-kB Activation  

E-Print Network (OSTI)

Molecular Cell Article XIAP Induces NF-kB Activation via the BIR1/TAB1 Interaction and BIR1 NF-kB and MAP kinase activation during TGF-b and BMP receptor signaling and upon overexpression. Here with TAB1 to induce NF-kB activation. TAB1 is an upstream adaptor for the activation of the kinase TAK1

Wu, Hao

22

NF kappa B expression and matrix metalloproteinase activity in hypertension  

E-Print Network (OSTI)

299-306, 1995. Baldwin A.S. The NF-kB and IkB Proteins: Newof transcription factor NF-kB in mouse glomerular mesangialwere then labeled with anti-NF-kB p65 rabbit polyclonal

Wu, Kwan-I

2009-01-01T23:59:59.000Z

23

Argonne partners with Metropolitan Water Reclamation District to study  

NLE Websites -- All DOE Office Websites (Extended Search)

Scientists at Argonne and the Metropolitan Water Reclamation District hope to map the Chicago River microbe population and how it changes during daily events like storms as well as larger events, such as the MWRD beginning to disinfect its discharge. Click to enlarge. Scientists at Argonne and the Metropolitan Water Reclamation District hope to map the Chicago River microbe population and how it changes during daily events like storms as well as larger events, such as the MWRD beginning to disinfect its discharge. Click to enlarge. Scientists at Argonne and the Metropolitan Water Reclamation District hope to map the Chicago River microbe population and how it changes during daily events like storms as well as larger events, such as the MWRD beginning to disinfect its discharge. Click to enlarge. Boats pass under the LaSalle St. Bridge in downtown Chicago. Scientists at Argonne are partnering with the Metropolitan Water Reclamation District to catalogue the microbe population of the Chicago River. Click to enlarge.

24

Optimizing Fire Station Locations for the Istanbul Metropolitan Municipality  

Science Conference Proceedings (OSTI)

The Istanbul Metropolitan Municipality IMM seeks to determine locations for additional fire stations to build in Istanbul; its objective is to make residences and historic sites reachable by emergency vehicles within five minutes of a fire station’s ... Keywords: fire station location, geographic information system, maximal-covering problem, set-covering problem

Emel Akta?; Özay Özayd?n; Burçin Bozkaya; Füsun Ülengin; ?ule Önsel

2013-05-01T23:59:59.000Z

25

Cloning and expression of equine NF-kB2  

E-Print Network (OSTI)

Equine infectious anemia virus (EIAV) is a macrophage-tropic retrovirus that causes persistent disease in horses and ponies. In addition to its structural proteins, EIAV encodes four regulatory/accessory genes, tat, rev, ttm, and S2. It has been documented EIAV S2 gene expression is essential for disease expression of EIAV. Using a yeast two-hybrid assay, it was shown that S2 protein interacts with human NF-KB2. NF-KB2 plays a key role in the alternative or non-canonical NF-KB pathway. In order to determine if the interaction of S2 with NF-KB2 might be relevant to equine disease, a cDNA representing full length equine NF-KB2 was generated in our laboratory using PCR and rapid amplification of cDNA ends. To our knowledge this is the first time that equine NF-KB2 cDNAs have been recovered and characterized. The sequence of equine NF-KB2 was 95% homologous to human overall, however a major difference was found in the ankyrin repeat region where protein-protein interactions occur. Two splice variants of equine NF-KB2 were found that correspond to splice variants of human NF- KB2. We tested the interaction of EIAV S2 and equine NF-KB2 using the yeast two hybrid system (Y2H) and co-immunoprecipitation. Unfortunately we were not able to detect an interaction between EIAV S2 and equine NF-KB2 in either system. Despite this result, NF-KB2 is an important component in the immune response so we examined its expression in equine macrophages. Moreover we were interested to know if EIAV might affect expression levels of equine NF-KB2, as NF-KB2 is a target of other viruses. Hence, the expression level of equine NF-KB2 was measured in uninfected and infected primary equine monocyte- derived macrophage (eMDM). Using quantitative PCR we determined that equine NF-KB2 gene expression is decreased in eMDM after 3 days post plating, about the time that monocytes start to differentiate into mature macrophages. However EIAV infection of eMDM upregulated the expression level of NF-KB2.

Mirhosseini, Negin

2008-05-01T23:59:59.000Z

26

CMRR-NF SEIS Scoping Information | National Nuclear Security...  

National Nuclear Security Administration (NNSA)

OctoberNovember 2010 Scoping meeting posters Welcome How You Can Submit Your Comments LANL Technical Areas Chemistry and Metallurgy Research Replacement (CMRR) CMRR-NF SEIS...

27

A NF-kappaB temporal code to ensure specificity in inflammatory signaling  

E-Print Network (OSTI)

requires the interaction of NF-kB with other transcriptionD. 2006. Circuitry of NF-kB Signaling. Immunological Reviewscontrol the dynamics of NF-kB signaling and gene expression.

Werner, Shannon L.

2009-01-01T23:59:59.000Z

28

Quantitative characterization and analysis of the dynamic NF-kappaB response in microglia  

E-Print Network (OSTI)

J, Wirth T, Schwaninger M: NF- kB is activated and promotesdomains of A20 downregulate NF-kB signalling. Nature 2004,Levchenko A: Understanding NF-kB signaling via mathematical

Sheppard, Patrick W; Sun, Xiaoyun; Emery, John F; Giffard, Rona G; Khammash, Mustafa

2011-01-01T23:59:59.000Z

29

Temporal encoding and homeostatic control in the IKK- kappaNF-kappaB signaling system  

E-Print Network (OSTI)

to control constitutive NF-kB activity." Molecular SystemsPharmacological Inhibitors on NF-kB Activation TimecoursesPharmacological Inhibitors on NF-kB Activation 102   x

Barken, Derren

2007-01-01T23:59:59.000Z

30

Washington Metropolitan Area Transit Authority: Compressed Natural Gas Transit Bus Evaluation  

DOE Green Energy (OSTI)

Evaluates compressed natural gas (CNG) powered transit buses at Washington Metropolitan Area Transit Authority (WMATA), providing a comparison between them and standard diesel transit buses.

Chandler, K.; Eberts, E.; Melendez, M.

2006-04-01T23:59:59.000Z

31

Car Based Transport and Transit Oriented Metropolitan —— Chinese Urban Motorization Pathways  

E-Print Network (OSTI)

Car Based Transport and Transit Oriented Metropolitan ——the automobile, the result is that car ownership has becomeof American families lack cars. In China, however, large

Ximing, Lu

2008-01-01T23:59:59.000Z

32

Homeostatic control of IkappaB metabolism determines NF- kappaB responsiveness  

E-Print Network (OSTI)

A. , and Ghosh, G. 2007. NF-kB dictates IkB degradationI?B protein within the NF-kB signaling module. ” Cell. 128:

O'Dea, Ellen Louise

2010-01-01T23:59:59.000Z

33

Planning for mitigating climate change risk to metropolitan areas (USA)  

E-Print Network (OSTI)

In the last couple of decades, there has been increasing evidence of changes in global climate. With urban areas identified as the primary contributors to the climate change, there is an impetus for initiatives to persuade major contributors of greenhouse gases to undertake policy measures for climate change mitigation. The support for such initiatives at the international level has been mixed with many nations, including the United States, not accepting the Kyoto protocol. In view of the evident disagreement at the international level, initiatives promoting local communities to adopt self regulating policies for climate change mitigation have gained importance. One such initiative is the Cities for Climate Protection (CCP) supported by the International Council for Local Environmental Initiatives. This research explores the differences in the socio-economic and civic characteristics of metropolitan areas in the contiguous United States that have committed to CCP (as a policy measure for climate change mitigation) to those that have not. The data in this study has been primarily collected from the census documents and government publications. The indicators are grouped into risk, stress and civic variables. The differences amongst the metropolitan areas with CCP committed jurisdictions and those with non-committed jurisdictions have been analyzed through statistical t-tests and use of geographical information system (GIS). The research reveals that metropolitan areas with a higher degree of risk are more likely to commit to climate change mitigation policies whereas those with higher stress index are less likely to commit. The metropolitan areas with higher civic index were also found more likely to commit to policy measures for climate change mitigation. The results of the study are significant as they reveal that communities that are at risk are not necessarily adding to the climate stress and those contributing the most to the climatic stress are not committed to climate change mitigation. The results of the study support the need to discontinue the closed box approach and instead adopt an approach with vertical integration. Cooperation and coordination amongst the hierarchical aggregate levels of communities, from a place to a region, are imperative for effective implementation of climate mitigation initiatives.

Grover, Himanshu

2006-08-01T23:59:59.000Z

34

Transitioning to a low-carbon climate-smart metropolitan America  

SciTech Connect

Meeting the climate challenge requires the leadership of metropolitan America. With two-thirds of the U.S. population and nearly three-quarters of the nation s economic activity residing in the nation s 100 largest metropolitan areas, urban centers account for much of the nation s greenhouse gas (GHG) emissions. At the same time, metropolitan America is the traditional locus of technological, entrepreneurial, and policy innovations. Its access to capital and a highly trained workforce have enabled metropolitan areas to play a pivotal role in expanding U.S. business opportunities while solving environmental challenges. With supportive federal policies, metropolitan areas can provide the low-carbon climate-smart leadership that is required to meet the nation s targets and timetables necessary to avoid dangerous levels of atmospheric greenhouse gases.

Brown, Dr. Marilyn Ann [Georgia Institute of Technology; Southworth, Frank [ORNL; Sarzynski, Andrea [Brookings Institution

2010-01-01T23:59:59.000Z

35

Modulation of the NF-kB Pathway by Bordetella  

E-Print Network (OSTI)

Background: Filamentous hemagglutinin (FHA) is a cell-associated and secreted adhesin produced by Bordetella pertussis with pro-apoptotic and pro-inflammatory activity in host cells. Given the importance of the NF-kB transcription factor family in these host cell responses, we examined the effect of FHA on NF-kB activation in macrophages and bronchial epithelial cells, both of which are relevant cell types during natural infection. Methodology/Principal Findings: Exposure to FHA of primary human monocytes and transformed U-937 macrophages, but not BEAS-2B epithelial cells, resulted in early activation of the NF-kB pathway, as manifested by the degradation of cytosolic IkBa, by NF-kB DNA binding, and by the subsequent secretion of NF-kB-regulated inflammatory cytokines. However, exposure of macrophages and human monocytes to FHA for two hours or more resulted in the accumulation of cytosolic IkBa, and the failure of TNF-a to activate NF-kB. Proteasome activity was attenuated following exposure of cells to FHA for 2 hours, as was the nuclear translocation of RelA in BEAS-2B cells. Conclusions: These results reveal a complex temporal dynamic, and suggest that despite short term effects to the contrary, longer exposures of host cells to this secreted adhesin may block NF-kB activation, and perhaps lead to a compromised immune response to this bacterial pathogen.

Pertussis Filamentous Hemagglutinin; Tzvia Abramson; Hassya Kedem; David A. Relman

2008-01-01T23:59:59.000Z

36

Kinetics of NF-kB nucleocytoplasmic transport probed by single-cell screening without imaging  

E-Print Network (OSTI)

Kinetics of NF-kB nucleocytoplasmic transport probed by single-cell screening without imaging Jun of nucleocytoplasmic transport of an important transcription factor NF-kB. With data collected from single cells, we activation barrier for NF-kB transport. Our data demonstrate that NF-kB nucleocytoplasmic transport fits

Lu, Chang

37

Charting the NF-kB Pathway Interactome Map  

E-Print Network (OSTI)

Inflammation is part of a complex physiological response to harmful stimuli and pathogenic stress. The five components of the Nuclear Factor kB (NF-kB) family are prominent mediators of inflammation, acting as key transcriptional regulators of hundreds of genes. Several signaling pathways activated by diverse stimuli converge on NF-kB activation, resulting in a regulatory system characterized by high complexity. It is increasingly recognized that the number of components that impinges upon phenotypic outcomes of signal transduction pathways may be higher than those taken into consideration from canonical pathway representations. Scope of the present analysis is to provide a wider, systemic picture of the NF-kB signaling system. Data from different sources such as literature, functional enrichment web resources, protein-protein interaction and pathway databases have been gathered, curated, integrated and analyzed in order to reconstruct a single, comprehensive picture of the proteins that interact with, and participate to the NF-kB activation system. Such a reconstruction shows that the NF-kB interactome is substantially different in quantity and quality of components with respect to canonical representations. The analysis highlights that several neglected but topologically central proteins may play a role in the activation of NF-kB mediated responses. Moreover the interactome structure fits with the characteristics of a bow tie architecture. This interactome is intended as an open network resource available for further development,

Paolo Tieri; Alberto Termanini; Elena Bellavista; Stefano Salvioli; Miriam Capri

2011-01-01T23:59:59.000Z

38

Upper-Level Atmospheric Circulation Patterns and Ground-Level Ozone in the Atlanta Metropolitan Area  

Science Conference Proceedings (OSTI)

The purpose of this paper is to identify middle-troposphere circulation patterns associated with high ozone concentrations during June–August of 2000–07 in the Atlanta, Georgia, metropolitan statistical area (MSA), which is located in the ...

Jeremy E. Diem; Melissa A. Hursey; Imani R. Morris; Amanda C. Murray; Ricardo A. Rodriguez

2010-11-01T23:59:59.000Z

39

The Evolution of Photochemical Smog in the Metropolitan Area of Santiago de Chile  

Science Conference Proceedings (OSTI)

In November and December 1996 the PHOTOCHEMICAL CAMPAIGN took place in the Metropolitan Area of Santiago de Chile and covered a range of simultaneous measurements of meteorological parameters and air chemical compounds, including ozone, carbon ...

Bernhard Rappenglück; Pedro Oyola; Ignacio Olaeta; Peter Fabian

2000-03-01T23:59:59.000Z

40

Daytime Local Circulations and Their Interactions in the Seoul Metropolitan Area  

Science Conference Proceedings (OSTI)

Daytime local circulations and their interactions in the Seoul, South Korea, metropolitan area are investigated using a high-resolution mesoscale model. It is found that the urban-breeze circulation interacts strongly with other local circulations,...

Young-Hee Ryu; Jong-Jin Baik

2013-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Simulations of the Urban Planetary Boundary Layer in an Arid Metropolitan Area  

Science Conference Proceedings (OSTI)

A modified version of the fifth-generation Pennsylvania State University–National Center for Atmospheric Research Mesoscale Model (MM5) was applied to the arid Phoenix, Arizona, metropolitan region. The ability of the model to simulate ...

Susanne Grossman-Clarke; Yubao Liu; Joseph A. Zehnder; Jerome D. Fast

2008-03-01T23:59:59.000Z

42

Metropolitan governance and local land use planning in Boston, Denver, and Portland  

E-Print Network (OSTI)

Metropolitan areas across the U.S. are characterized by sprawling development which uses larger amounts of open space than necessary, leads to the inefficient use of energy and water, increases social inequality, and causes ...

Rosan, Christina

2007-01-01T23:59:59.000Z

43

Development of a Statistical Model for Forecasting Episodes of Visibility Degradation in the Denver Metropolitan Area  

Science Conference Proceedings (OSTI)

In 1990, the State of Colorado implemented a visibility standard of 0.076 km?1 of beta extinction for the Denver metropolitan area. Meteorologists with Colorado's Air Pollution Control Division forecast high pollution days associated with ...

P. J. Reddy; D. E. Barbarick; R. D. Osterburg

1995-03-01T23:59:59.000Z

44

Climatological Analyses of Thunderstorms and Flash Floods in the Baltimore Metropolitan Region  

Science Conference Proceedings (OSTI)

The climatology of thunderstorms and flash floods in the Baltimore, Maryland, metropolitan region is examined through analyses of cloud-to-ground (CG) lightning observations from the National Lightning Detection Network (NLDN) and discharge ...

Alexandros A. Ntelekos; James A. Smith; Witold F. Krajewski

2007-02-01T23:59:59.000Z

45

Economic impact of M.I.T. on Cambridge and Metropolitan Boston  

E-Print Network (OSTI)

This thesis investigated the economic impact of the Massachusetts Institute of Technology on its host city, Cambridge, and upon the Boston Metropolitan Area. The primary purpose was to develop sufficient information about ...

Finberg, Irving William

1964-01-01T23:59:59.000Z

46

Trends in Extreme Temperatures in Relation to Urbanization in the Twin Cities Metropolitan Area, Minnesota  

Science Conference Proceedings (OSTI)

The long-term trends in extreme summer season temperatures across the Twin Cities Metropolitan Area (TCMA) associated with urbanization are examined. To assess trends in extreme temperature data, maximum and minimum temperatures from 1975 to 2002 ...

Shouraseni Sen Roy; Fei Yuan

2009-03-01T23:59:59.000Z

47

The variation of capitalization rates across submarkets within the same metropolitan area  

E-Print Network (OSTI)

This paper investigates the variation of capitalization rates across submarkets within the same metropolitan area by using a database with 73 transactions of office properties located in nine submarkets of Atlanta during ...

Yu, Yisheng, 1973-

2004-01-01T23:59:59.000Z

48

Set of Comparable Carbon Footprints for Highway Travel in Metropolitan America  

Science Conference Proceedings (OSTI)

The authors describe the development of a set of carbon dioxide emissions estimates for highway travel by automobile, truck, bus and other public transit vehicle movements within the nation s 100 largest metropolitan areas, in calendar year 2005. Considerable variability is found to exist across metropolitan areas when these greenhouse gas emissions are measured on a per capita and a per gross metropolitan product (GMP) basis. Least square regression modeling shows a relationship between emissions per capita and per GMP with truck traffic share, transit share, employment density, population dispersion within the metro area, and GMP per capita. As a result many of the nation s largest metropolitan areas tend to have lower CO2 emissions per capita and per GMP than smaller and more recently developed metro areas.

Southworth, Frank [ORNL; Sonnenberg, Anthon [Georgia Institute of Technology

2011-01-01T23:59:59.000Z

49

Unequal development : decentralization and fiscal disparities in the Metropolitan Zone of the Valley of Mexico  

E-Print Network (OSTI)

This study is about the impact of decentralization in metropolitan areas. Studies of fiscal decentralization have largely centered on the formal tiers of government, without looking at the effects of this process on the ...

Raich, Uri

2006-01-01T23:59:59.000Z

50

NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function  

SciTech Connect

NF45/ILF2 associates with NF90/ILF3 in the nucleus and regulates IL-2 gene transcription at the antigen receptor response element (ARRE)/NF-AT DNA target sequence (P.N. Kao, L. Chen, G. Brock, J. Ng, A.J. Smith, B. Corthesy, J. Biol. Chem. 269 (1994) 20691-20699). NF45 is widely expressed in normal tissues, especially testis, brain, and kidney, with a predominantly nuclear distribution. NF45 mRNA expression is increased in lymphoma and leukemia cell lines. The human and murine NF45 proteins differ only by substitution of valine by isoleucine at amino acid 142. Fluorescence in situ hybridization localized the human NF45 gene to chromosome 1q21.3, and mouse NF45 gene to chromosome 3F1. Promoter analysis of 2.5 kB of the murine NF45 gene reveals that significant activation is conferred by factors, possible including NF-Y, that bind to the CCAAT-box sequence. The function of human NF45 in regulating IL-2 gene expression was characterized in Jurkat T-cells stably transfected with plasmids directing expression of NF45 cDNA in sense or antisense orientations. NF45 sense expression increased IL-2 luciferase reporter gene activity 120-fold, and IL-2 protein expression 2-fold compared to control cells. NF45 is a highly conserved, regulated transcriptional activator, and one target gene is IL-2.

Zhao Guohua [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States); Shi Lingfang [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States); Qiu Daoming [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States); Hu Hong [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States); Kao, Peter N. [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States)]. E-mail: peterkao@stanford.edu

2005-05-01T23:59:59.000Z

51

Transcriptional regulation of antimicrobial peptide induction by NF-[kappa]B family members during the Drosophila melanogaster immune response  

E-Print Network (OSTI)

Dl), a member of the NF-kB family, through degradation ofworks in conjunction with NF-kB members to regulate fat bodystandard deviation. (C). Role of fly NF-kB proteins in AttA

Busse, Matthew Schmidt

2007-01-01T23:59:59.000Z

52

Mathematical model of NF-kB regulatory module  

E-Print Network (OSTI)

The two-feedback-loop regulatory module of nuclear factor kB (NF-kB) signaling pathway is modeled by means of ordinary differential equations. The constructed model involves two-compartment kinetics of the activators IkB (IKK) and NF-kB; the inhibitors A20 and IkBa; and their complexes. In resting cells, the unphosphorylated IkBa binds to NF-kB and sequesters it in an inactive form in the cytoplasm. In response to extracellular signals such as tumor necrosis factor or interleukin-1, IKK is transformed from its neutral form (IKKn) into its active form (IKKa), a form capable of phosphorylating IkBa; leading to IkBa degradation. Degradation of IkBa releases the main activator NF-kB; which then enters the nucleus and triggers transcription of the inhibitors and numerous other genes. The newly synthesized IkBa leads NF-kB out of the nucleus and sequesters it in the cytoplasm, while A20 inhibits IKK converting IKKa into the inactive form (IKKi), a form different from IKKn, no longer capable of phosphorylating IkBa: After parameter fitting, the proposed model is able to properly reproduce time behavior of all variables for which the data are available: NF-kB; cytoplasmic IkBa; A20 and IkBa mRNA transcripts, IKK and IKK catalytic activity in both wild-type and A20-deficient cells. The model allows detailed analysis of kinetics of the involved proteins and their complexes and gives the predictions of the possible responses of whole kinetics to the change in the level of a given activator or inhibitor.

Tomasz Lipniacki A; Pawel Paszek B; Allan R. Brasier D; Bruce Luxon C; Marek Kimmel B

2003-01-01T23:59:59.000Z

53

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1  

E-Print Network (OSTI)

super family pathway and NF-kB pathway, such as TRADD, RELB,genes from wound healing and NF-kB signaling. Samples in the

Verhaak, Roel GW

2010-01-01T23:59:59.000Z

54

Regional planning and operations architectures as means to foster transportation integration in the Mexico City Metropolitan Area  

E-Print Network (OSTI)

The MCMA complexity in political, institutional, economical, and jurisdictional terms has resulted in limited coordination between MCMA authorities that in conjunction with the limited role of metropolitan transportation ...

Ortiz Mantilla, Bernardo Jose, 1977-

2005-01-01T23:59:59.000Z

55

Intra-metropolitan health disparities in Canada: Studying how and why globalization matters, and what to do about it  

E-Print Network (OSTI)

of Supermarkets in Metropolitan Detroit. American Journal ofAn Economic Development Agenda for Detroit.Detroit: Widgetripper Press [on file with author]. Maher, K.

Schrecker, Ted

2007-01-01T23:59:59.000Z

56

Women and the high school principalship: metropolitan detroit principals' and superintendents' perceptions regarding barriers and facilitators for job attainment.  

E-Print Network (OSTI)

??WOMEN AND THE HIGH SCHOOL PRINCIPALSHIP: METROPOLITAN DETROIT PRINCIPALS' AND SUPERINTENDENTS' PERCEPTIONS REGARDING BARRIERS AND FACILITATORS FOR JOB ATTAINMENT by HEIDI SCHNABEL KATTULA 2011 Advisor:… (more)

Schnabel Kattula, Heidi

2011-01-01T23:59:59.000Z

57

Physiological functions for brain NF-kB Mollie K. Meffert and David Baltimore  

E-Print Network (OSTI)

Physiological functions for brain NF-kB Mollie K. Meffert and David Baltimore Division of BiologyB (NF-kB) family of transcription factors are activated within the CNS in pathological settings of the mechanisms of Ca2C -responsive activation and synaptic signaling to the nucleus by NF-kB transcription

Baltimore, David

58

Single-cell NF-kB dynamics reveal digital activation and analogue information processing  

E-Print Network (OSTI)

LETTERS Single-cell NF-kB dynamics reveal digital activation and analogue information processing information to the gene expression programs by means of the transcription factor nuclear factor (NF)-kB. We measured NF-kB activity in thousands of live cells under TNF-a doses covering four orders of magnitude. We

Quake, Stephen R.

59

ORIGINAL ARTICLE NF-jB activation by combinations of NEMO SUMOylation and ATM  

E-Print Network (OSTI)

The Rel/NF-kB family of transcription factors has been intensively studied as an important paradigm expression profiles (reviewed in Hayden and Ghosh (2004)). The proto- typical mammalian NF-kB complex, a p50 necrosis factor (TNF), interleukin-1 and bacterial lipopolysaccharide (LPS), activate NF-kB via convergence

Miyamoto, Shigeki

60

Dual Delayed Feedback Provides Sensitivity and Robustness to the NF-kB Signaling Module  

E-Print Network (OSTI)

Dual Delayed Feedback Provides Sensitivity and Robustness to the NF-kB Signaling Module Diane M of the transcription factor NF-kB. Linear stability analysis of the model shows that oscillatory frequency is a hard system minimizes stochastic excursions of the output to produce a robust NF-kB response. Citation: Longo

Hasty, Jeff

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

NF-[kappa]B RelB/p52 heterodimer : biogenesis and DNA recognition  

E-Print Network (OSTI)

A fourth IkB protein in the NF-kB signaling module. Cell, InCD28 is mediated through an NF-kB-like response element. JTo further test how other NF-kB dimers interact with CREB,

Fusco, Amanda J.

2007-01-01T23:59:59.000Z

62

Vol. 2003, Issue 36, pp. nf17, 10 September 2003 [DOI: 10.1126/sageke.2003.36.nf17  

E-Print Network (OSTI)

Document URL: http://sageke.sciencemag.org/cgi/content/full/sageke;2003/36/nf17 Science , . This article sophomore year in 1987. "It was actually a science experiment gone awry," confesses Gazzaley with a giggle into the toilet bowl. But he had miscalculated the power of the reaction: The resulting explosion shook

63

b-Arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-jB  

E-Print Network (OSTI)

: b-arrestin2; CK2; NF-kB Introduction The UV response in mammalian cells is mediated through activation of several transcription factors, including NF-kB (Shaulian et al, 2000). In resting cells, NF-kB by Silverman and Maniatis, 2001). The binding of IkB to NF-kB masks the nuclear localization sequences (NLS

Tian, Weidong

64

COMMD1 promotes the ubiquitination of NF-jB subunits through a cullin-containing ubiquitin  

E-Print Network (OSTI)

& transcription; proteins Keywords: COMMD1; cullin; NF-kB; transcription; ubiquitination Introduction NF-kB im- munity, apoptosis, and cell cycle progression (Karin and Lin, 2002). In mammals, NF-kB subunits into the mature p50 and p52 subunits, respectively. NF-kB is ordinarily sequestered in the cytoplasm

Burstein, Ezra

65

NF-kB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1a  

E-Print Network (OSTI)

LETTERS NF-kB links innate immunity to the hypoxic response through transcriptional regulation, regulated by several transcription factors, among which NF-kB plays a central role5,6 . NF-kB activation between NF-kB and HIF-1a has proven elusive. Using in vitro systems, it was reported that HIF-1a activates

Nizet, Victor

66

Conservation justice in metropolitan Cape Town: A study at the Macassar Dunes Conservation Area  

E-Print Network (OSTI)

Conservation justice in metropolitan Cape Town: A study at the Macassar Dunes Conservation Area J xxxx Keywords: Conservation justice Community-based conservation South Africa Urban conservation Stakeholder analysis a b s t r a c t Conservation justice, a concept analogous to environmental justice

Silander Jr., John A.

67

Observed Structure of a Land Breeze Head in the Tokyo Metropolitan Area  

Science Conference Proceedings (OSTI)

The penetration of a land breeze front and its turbulence structure was observed at the center of the Tokyo metropolitan area on 27–28 January 1983. A turbulence sonde, small tethersonde and an acoustic sounder were used for the experiment. The ...

Toshimasa Ohara; Itsushi Uno; Shinji Wakamatsu

1989-08-01T23:59:59.000Z

68

The Transportation Energy and Carbon Footprints of the 100 Largest U.S. Metropolitan Areas  

Science Conference Proceedings (OSTI)

We present estimates of the automobile and truck travel based energy and carbon footprints of the largest 100 U.S. metropolitan areas. The footprints are based on the estimated vehicle miles traveled and the transportation fuels consumed. Results are presented on an annual basis and represent end use emissions only. Total carbon emissions, emissions per capita, and emissions per dollar of gross metropolitan product are reported. Two years of annual data were examined, 2000 and 2005, with most of the in-depth analysis focused on the 2005 results. In section 2 we provide background data on the national picture and derive some carbon and energy consumption figures for the nation as a whole. In section 3 of the paper we examine the metropolitan area-wide results based on the sums and averages across all 100 metro areas, and compare these with the national totals and averages. In section 4 we present metropolitan area specific footprints and examine the considerable variation that is found to exist across individual metro areas. In doing so we pay particular attention to the effects that urban form might have on these differences. Finally, section 5 provides a summary of major findings, and a list of caveats that need to be borne in mind when using the results due to known limitations in the data sources used.

Southworth, Frank [ORNL; Sonnenberg, Anthon [Georgia Institute of Technology; Brown, Marilyn A [ORNL

2008-01-01T23:59:59.000Z

69

Comparison of the Impact of Global Climate Changes and Urbanization on Summertime Future Climate in the Tokyo Metropolitan Area  

Science Conference Proceedings (OSTI)

In this study, the impact of global climate change and anticipated urbanization over the next 70 years is estimated with regard to the summertime local climate in the Tokyo metropolitan area (TMA), whose population is already near its peak now. ...

Sachiho A. Adachi; Fujio Kimura; Hiroyuki Kusaka; Tomoshige Inoue; Hiroaki Ueda

2012-08-01T23:59:59.000Z

70

Urban Modifications in a Mesoscale Meteorological Model and the Effects on Near-Surface Variables in an Arid Metropolitan Region  

Science Conference Proceedings (OSTI)

A refined land cover classification for the arid Phoenix (Arizona) metropolitan area and some simple modifications to the surface energetics were introduced in the fifth-generation Pennsylvania State University–National Center for Atmospheric ...

Susanne Grossman-Clarke; Joseph A. Zehnder; William L. Stefanov; Yubao Liu; Michael A. Zoldak

2005-09-01T23:59:59.000Z

71

The case for pension plan and university endowment equity investment in brownfields in the urban core of major metropolitan areas  

E-Print Network (OSTI)

The purpose of this thesis is to present a case for institutional equity investment in brownfields in the urban core of major metropolitan areas. Pension plans and university endowments are the primary institutional investors ...

Larsen, Tamara C. (Tamara Candace), 1977-

2003-01-01T23:59:59.000Z

72

In situ measurements of speciated atmospheric mercury and the identification of source regions in the Mexico City Metropolitan Area  

E-Print Network (OSTI)

In order to expand the currently limited understanding of atmospheric mercury source-receptor relationships in the Mexico City Metropolitan Area, real time measurements of atmospheric mercury were made at a downtown urban ...

Rutter, A. P.

73

A Set of Comparable Carbon Footprints for Auto, Truck and Transit Travel in Metropolitan America  

NLE Websites -- All DOE Office Websites (Extended Search)

Set of Comparable Carbon Footprints for Highway Travel in Set of Comparable Carbon Footprints for Highway Travel in Metropolitan America by Frank Southworth* and Anthon Sonnenberg** August 31, 2009 *Corresponding author: Senior R&D Staff, Oak Ridge National Laboratory and Principal Research Scientist Georgia Institute of Technology 790 Atlantic Drive SEB Building, Room 324 Atlanta, GA 30332-0355 E-mail: frank.southworth@ce.gatech.edu ** PhD Student, Georgia Institute of Technology School of Civil and Environmental Engineering Georgia Institute of Technology 1 Abstract The authors describe the development of a set of carbon dioxide emissions estimates for highway travel by automobile, truck, bus and other public transit vehicle movements within the nation's 100 largest metropolitan areas, in calendar year 2005. Considerable variability is found to exist

74

Emission Testing of Washington Metropolitan Area Transit Authority (WMATA) Natural Gas and Diesel Transit Buses  

Alternative Fuels and Advanced Vehicles Data Center (EERE)

Emission Testing of Washington Emission Testing of Washington Metropolitan Area Transit Authority (WMATA) Natural Gas and Diesel Transit Buses M. Melendez, J. Taylor, and J. Zuboy National Renewable Energy Laboratory W.S. Wayne West Virginia University D. Smith U.S. Department of Energy Technical Report NREL/TP-540-36355 December 2005 Emission Testing of Washington Metropolitan Area Transit Authority (WMATA) Natural Gas and Diesel Transit Buses M. Melendez, J. Taylor, and J. Zuboy National Renewable Energy Laboratory W.S. Wayne West Virginia University D. Smith U.S. Department of Energy Prepared under Task No. FC05-9000 Technical Report NREL/TP-540-36355 December 2005 National Renewable Energy Laboratory 1617 Cole Boulevard, Golden, Colorado 80401-3393 303-275-3000 * www.nrel.gov

75

Residential Segregation,Spatial Mismatch and Economic Growth across US Metropolitan Area  

Science Conference Proceedings (OSTI)

Numerous studies have demonstrated the detrimental influence of residential segregation on poor inner-city residents. This study examines the impact of residential segregation on the welfare of populations in US metropolitan areas using economic growth as the indicator. Panel data of US metropolitan areas spanning 25 years, 1980 2005, are used to analyze the effect of segregation on economic growth. The results show that both racial and skill segregation have a negative impact on short and long-term economic growth, which have increased over time. Further, the negative impact of the variables associated with spatial mismatch is also revealed. The results clearly point to the need for mobility policies that favor non-White households and comprehensive strategies that promote economic opportunities in low-resource communities in the US.

Campbell, Dr Harrison [University of North Carolina, Charlotte] [University of North Carolina, Charlotte; Li, Huiping [ORNL] [ORNL

2013-01-01T23:59:59.000Z

76

Regional Economic Benefits from Electric Transportation: Case Study of the Cleveland, Ohio Metropolitan Statistical Area  

Science Conference Proceedings (OSTI)

This study analyzes the economic impacts due to electric drive vehicle (EDVs) market penetration in the Cleveland metropolitan statistical area (MSA). Specifically, the study examines the economic impacts due to petroleum displacement and decreased pollution control compliance costs for local industry. The study applies a regional input-out put analysis to develop regional economic impact multipliers (REIMs) appropriate for EDV evaluation. These REIMs are integrated into a spreadsheet based Cleveland EDV...

2006-12-12T23:59:59.000Z

77

METRO Metropolitan Exposition Recreation Commission MERC Facilities Efficiently Maintained – Maybe Too Efficiently  

E-Print Network (OSTI)

To the Metro Council, Metropolitan Exposition Recreation Commission and Metro-area citizens: As part of the Metro Auditor’s risk assessment and audit plan, we studied facility care and capital improvement processes at the Metropolitan Exposition Recreation Commission (MERC), a unit of Metro. Facility care includes janitorial and repair and maintenance activities. Capital improvement processes include plans for determining necessary capital improvements and obtaining adequate, reliable funding for capital renewal and replacement projects. MERC owns public assembly facilities with a book value of over $200 million. It manages the Oregon Convention Center, the Portland Center for the Performing Arts and the Portland Metropolitan Exposition Center. The cost of maintaining and safeguarding these facilities consumes about 14 % of MERC’s operating revenues each year. The cost of MERC facilities care activities benchmark below that of other facilities across the nation. While low cost is generally a positive, some improvements in facility care practices and capital improvement processes could be made. We recommend that MERC: Evaluate the adequacy of staffing for janitorial and maintenance activities and add electrical expertise where needed.

Alexis Dow Cpa; A Uditor; A Lexis; D Ow

2006-01-01T23:59:59.000Z

78

Low Dose Radiation Research Program: Regulation of NF-kB and MnSOD in Low  

NLE Websites -- All DOE Office Websites (Extended Search)

NF-kB and MnSOD in Low Dose Radiation-Induced Adaptive NF-kB and MnSOD in Low Dose Radiation-Induced Adaptive Responses in Mouse and Human Skin Cells Jian Jian Li School of Health Sciences, Purdue University West Lafayette, Indiana Why this Project? To determine if low dose ionizing radiation-induced adaptive responses in skin cells are mediated by activation of signaling networks. Project Goals To evaluate the signaling networks involving transcription factor NF-kB and the mitochondrial antioxidant protein MnSOD. To determine if NF-kB is activated by low dose radiation in vivo. To determine if NF-kB activation is critical in the pathways that produce adaptive responses. Experimental Approach Cells transfected with NF-kB luciferase responder genes will be used to define a dose-response relationship for activation of the NF-kB gene. NF-kB

79

The IkBa/NF-kB complex has two hot spots, one at either end of the interface  

E-Print Network (OSTI)

The IkBa/NF-kB complex has two hot spots, one at either end of the interface SIMON BERGQVIST,1 of NF-kB family members via its ankyrin repeat (AR) domain. The binding affinity of IkBa with NF-kB(p50/p65) heterodimers and NF-kB(p65/65) homodimers is in the picomolar range, and in the cell

Komives, Elizabeth A.

80

Myelin Activates FAK/Akt/NF-kB Pathways and Provokes CR3-Dependent Inflammatory Response in Murine  

E-Print Network (OSTI)

Myelin Activates FAK/Akt/NF-kB Pathways and Provokes CR3-Dependent Inflammatory Response in Murine is through activation of FAK/PI3K/Akt/NF-kB signaling pathways and CR3 contributes to myelin-induced PI3K/Akt/NF-kB) are not able to activate NF-kB signaling pathway. In conclusion, our results demonstrate a crucial role

Fan, Jianqing

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

An Epigenetic Switch Involving NF-kB, Lin28, Let-7 MicroRNA, and IL6 Links  

E-Print Network (OSTI)

An Epigenetic Switch Involving NF-kB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell to cancer, and NF-kB appears to play a causa- tive role, but the mechanisms are poorly understood. We show activation triggers an inflammatory response mediated by NF-kB that directly activates Lin28 transcription

82

NMR studies of the transcriptional inhibitor I kappa B alpha and its interaction with the transcription factor NF kappa B  

E-Print Network (OSTI)

E. A. (2008) The IkBa/NF-kB complex has two hot-spots, oneThe genes regulated by NF-kB fall into various functionaldimerization domains and NF-kB p65 amino-terminal domain (

Cervantes, Carla F.

2010-01-01T23:59:59.000Z

83

Dying for NF-jB? Control of cell death by transcriptional regulation of the apoptotic machinery  

E-Print Network (OSTI)

Ezra Burstein and Colin S DuckettÃ? The transcription factor nuclear factor kB (NF-kB) is a pleiotropic signals and cellular stress. Several hundred cellular genes have been shown to be regulated by NF-kB showed that loss or suppression of NF-kB results in an enhanced sensitivity to apoptosis. In the ensuing

Burstein, Ezra

84

WntD is a feedback inhibitor of Dorsal/NF-kB in Drosophila development and immunity  

E-Print Network (OSTI)

WntD is a feedback inhibitor of Dorsal/NF-kB in Drosophila development and immunity Michael D. Gordon1 , Marc S. Dionne2 , David S. Schneider2 & Roel Nusse1 Regulating the nuclear factor-kB (NF-kB melanogaster have proved fruitful in determining the signals used to control NF-kB proteins, beginning

Bejerano, Gill

85

NF-{kappa}B regulates Lef1 gene expression in chondrocytes  

SciTech Connect

The relation of Wnt/{beta}-catenin signaling to osteoarthritis progression has been revealed with little information on the underlying molecular mechanism. In this study we found overexpression of Lef1 in cartilage tissue of osteoarthritic patients and elucidated molecular mechanism of NF-{kappa}B-mediated Lef1 gene regulation in chondrocytes. Treatment of IL-1{beta} augmented Lef1 upregulation and nuclear translocation of NF-{kappa}B in chondrocytes. Under IL-1{beta} signaling, treatment of NF-{kappa}B nuclear translocation inhibitor SN-50 reduced Lef1 expression. A conserved NF-{kappa}B-binding site between mouse and human was selected through bioinformatic analysis and mapped at the 14 kb upstream of Lef1 transcription initiation site. NF-{kappa}B binding to the site was confirmed by chromatin immunoprecipitation assay. Lef1 expression was synergistically upregulated by interactions of NF-{kappa}B with Lef1/{beta}-catenin in chondrocytes. Our results suggest a pivotal role of NF-{kappa}B in Lef1 expression in arthritic chondrocytes or cartilage degeneration.

Yun, Kangsun [Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712 (Korea, Republic of); Choi, Yoo Duk [Department of Pathology, Chonnam National University Medical School, Gwangju 501-749 (Korea, Republic of); Nam, Jong Hee [Department of Pathology, Chonnam National University Medical School, Gwangju 501-749 (Korea, Republic of); Park, Zeeyoung [Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712 (Korea, Republic of); Im, Sin-Hyeog [Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712 (Korea, Republic of)]. E-mail: imsh@gist.ac.kr

2007-06-08T23:59:59.000Z

86

La activacin de NF-kB, indicador de recada en el cncer de mama  

E-Print Network (OSTI)

La activación de NF-kB, indicador de recaída en el cáncer de mama La ausencia de la proteína 14 proteico relacio- nado con la progresión tumoral, NF-kB, según apunta un estudio en PLoS ONE realiza- do activación de NF-kB en los tumores como el mejor indi- cador de recaída en las pa- cientes de cáncer de mama

Foissac, Sylvain

87

Metropolitan Undergraduate  

E-Print Network (OSTI)

opportunities, careers and employability 14 Learn in an enriching environment with outstanding facilities 15 Essential Information How to apply Entry requirements, English language, visa information 45 Support your course. We combine world-class learning and teaching facilities underpinned by a £350million

88

Polycystin-1 promotes PKC{alpha}-mediated NF-{kappa}B activation in kidney cells  

Science Conference Proceedings (OSTI)

Polycystin-1 (PC1), the PKD1 gene product, is a membrane receptor which regulates many cell functions, including cell proliferation and apoptosis, both typically increased in cyst lining cells in autosomal dominant polycystic kidney disease. Here we show that PC1 upregulates the NF-{kappa}B signalling pathway in kidney cells to prevent cell death. Human embryonic kidney cell lines (HEK293{sup CTT}), stably expressing a PC1 cytoplasmic terminal tail (CTT), presented increased NF-{kappa}B nuclear levels and NF-{kappa}B-mediated luciferase promoter activity. This, consistently, was reduced in HEK293 cells in which the endogenous PC1 was depleted by RNA interference. CTT-dependent NF-{kappa}B promoter activation was mediated by PKC{alpha} because it was blocked by its specific inhibitor Ro-320432. Furthermore, it was observed that apoptosis, which was increased in PC1-depleted cells, was reduced in HEK293{sup CTT} cells and in porcine kidney LtTA cells expressing a doxycycline-regulated CTT. Staurosporine, a PKC inhibitor, and parthenolide, a NF-{kappa}B inhibitor, significantly reduced the CTT-dependent antiapoptotic effect. These data reveal, therefore, a novel pathway by which polycystin-1 activates a PKC{alpha}-mediated NF-{kappa}B signalling and cell survival.

Banzi, Manuela [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy); Aguiari, Gianluca [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy); Trimi, Viky [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy); Mangolini, Alessandra [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy); Pinton, Paolo [General Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara (Italy); Witzgall, Ralph [Institute for Molecular and Cellular Anatomy, University of Regensburg, Regensburg (Germany); Rizzuto, Rosario [General Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara (Italy); Senno, Laura del [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy)]. E-mail: sen@unife.it

2006-11-17T23:59:59.000Z

89

MicroRNAs Modulate the Dynamics of the NF-kB Signaling Pathway  

E-Print Network (OSTI)

Background: NF-kB, a major transcription factor involved in mammalian inflammatory signaling, is primarily involved in regulation of response to inflammatory cytokines and pathogens. Its levels are tightly regulated since uncontrolled inflammatory response can cause serious diseases. Mathematical models have been useful in revealing the underlying mechanisms, the dynamics, and other aspects of regulation in NF-kB signaling. The recognition that miRNAs are important regulators of gene expression, and that a number of miRNAs target different components of the NF-kB network, motivate the incorporation of miRNA regulated steps in existing mathematical models to help understand the quantitative aspects of miRNA mediated regulation. Methodology/Principal findings: In this study, two separate scenarios of miRNA regulation within an existing model are considered. In the first, miRNAs target adaptor proteins involved in the synthesis of IKK that serves as the NF-kB activator. In the second, miRNAs target different isoforms of IkB that act as NF-kB inhibitors. Simulations are carried out under two different conditions: when all three isoforms of IkB are present (wild type), and when only one isoform (IkBa) is present (knockout type). In both scenarios, oscillations in the NF-kB levels are observed and are found to be dependent on the levels of miRNAs. Conclusions/Significance: Computational modeling can provide fresh insights into intricate regulatory processes. The

Ida Vaz; Arvind Singh Mer; Alok Bhattacharya; Ramakrishna Ramaswamy

2011-01-01T23:59:59.000Z

90

Optineurin Is Required for CYLD-Dependent Inhibition of TNFa-Induced NF-kB Activation  

E-Print Network (OSTI)

The nuclear factor kappa B (NF-kB) regulates genes that function in diverse cellular processes like inflammation, immunity and cell survival. The activation of NF-kB is tightly controlled and the deubiquitinase CYLD has emerged as a key negative regulator of NF-kB signalling. Optineurin, mutated in certain glaucomas and amyotrophic lateral sclerosis, is also a negative regulator of NF-kB activation. It competes with NEMO (NF-kB essential modulator) for binding to ubiquitinated RIP (receptor interacting protein) to prevent NF-kB activation. Recently we identified CYLD as optineurin-interacting protein. Here we have analysed the functional significance of interaction of optineurin with CYLD. Our results show that a glaucomaassociated mutant of optineurin, H486R, is altered in its interaction with CYLD. Unlike wild-type optineurin, the H486R mutant did not inhibit tumour necrosis factor a (TNFa)-induced NF-kB activation. CYLD mediated inhibition of TNFainduced NF-kB activation was abrogated by expression of the H486R mutant. Upon knockdown of optineurin, CYLD was unable to inhibit TNFa-induced NF-kB activation and showed drastically reduced interaction with ubiquitinated RIP. The level of ubiquitinated RIP was increased in optineurin knockdown cells. Deubiquitination of RIP by over-expressed CYLD was abrogated in optineurin knockdown cells. These results suggest that optineurin regulates NF-kB activation by mediating

Ananthamurthy Nagabhushana; Megha Bansal; Ghanshyam Swarup

2010-01-01T23:59:59.000Z

91

Imaging Pulmonary NF-kappaB Activation and Therapeutic Effects of MLN120B and TDZD-8  

E-Print Network (OSTI)

NF-kB activation is a critical signaling event in the inflammatory response and has been implicated in a number of pathological lung diseases. To enable the assessment of NF-kB activity in the lungs, we transfected a luciferase based NF-kB reporter into the lungs of mice or into Raw264.7 cells in culture. The transfected mice showed specific luciferase expression in the pulmonary tissues. Using these mouse models, we studied the kinetics of NF-kB activation following exposure to lipopolysaccharide (LPS). The Raw264.7 cells expressed a dose-dependent increase in luciferase following exposure to LPS and the NF-kB reporter mice expressed luciferase in the lungs following LPS challenge, establishing that bioluminescence imaging provides adequate sensitivity for tracking the NF-kB activation pathway. Interventions affecting the NF-kB pathway are promising clinical therapeutics, thus we further examined the effect of IKK-2 inhibition by MLN120B and glycogen synthase kinase 3 beta inhibition by TDZD-8 on NF-kB activation. Pre-treatment with either MLN120B or TDZD-8 attenuated NF-kB activation in the pulmonary tissues, which was accompanied with suppression of pro-inflammatory chemokine MIP-1ß and induction of anti-inflammatory cytokine IL-10. In summary, we have established an imaging based approach for noninvasive and longitudinal assessment of NF-kB activation and regulation during acute lung injury. This approach will

Dan Ansaldi; Eldad A. Hod; Fabio Stellari; Jae-beom Kim; Mark Roskey; Kevin P. Francis; Rajendra Singh; Ning Zhang

2011-01-01T23:59:59.000Z

92

A test of first order scaling in Nf=2 QCD  

E-Print Network (OSTI)

We complete our analysis of Nf=2 QCD based on the lattice staggered fermion formulation. Using a series of Monte Carlo simulations at fixed (amq*Ls^yh) one is able to test the universality class with given critical exponent yh. This strategy has been used to test the O(4) universality class and it has been presented at the previous Lattice conferences. No agreement was found with simulations in the mass range amq=[0.01335,0.15] using lattices with Ls=16 up to 32 and Lt=4. With the same strategy, we now investigate the possibility of a first order transition using a new set of Monte Carlo data corresponding to yh=3 in the same mass and volume range as the one used for O(4). A substantial agreement is observed both in the specific heat scaling and in the scaling of the chiral condensate, while the chiral susceptibilities still presents visible deviation from scaling in the mass range explored.

G. Cossu; M. D'Elia; A. Di Giacomo; C. Pica

2007-09-30T23:59:59.000Z

93

The effectiveness of jobs-housing balance as a strategy for reducing traffic congestion: a study of metropolitan Bangkok  

E-Print Network (OSTI)

Bangkok is widely known for its severe traffic congestion. The Thai government advocates the concept of jobs and housing balance (JHB) as a strategy for reducing traffic congestion in Metropolitan Bangkok. The basic idea is to decentralize the jobs to the neighboring provinces so that the commuters would live closer to their workplaces and thereby alleviate traffic congestion. The main purpose of this research is to examine empirically the effectiveness of JHB in reducing the severity of traffic congestion in the Bangkok Metropolitan Region. For this purpose, three data sets derived from the Bangkok Metropolitan Region Extended City Model (BMR-ECM) were obtained from the Office of the Commission for the Management of Land Traffic and the National Statistical Office of Thailand. Travel time index (TTI) was developed to measure congestion. In addition to JHB, a number of land use variables were included in the analysis. They are population density, school density, and job accessibility index. Multiple regression models of TTI as functions of JHB and other variables were estimated at two geographic scales: subsector and traffic analysis zone (TAZ). The study finds JHB is significant in influencing congestion levels in the Bangkok Metropolitan Region. Other influential factors include the population density, school density, and job accessibility. All of these factors are found to be statistically significant in explaining the variation of traffic congestion at the traffic analysis zone level, but not at the subsector level, however.

Lobyaem, Sonchai

2006-08-01T23:59:59.000Z

94

Volcanic Ash Transport from Mount Asama to the Tokyo Metropolitan Area Influenced by Large-Scale Local Wind Circulation  

Science Conference Proceedings (OSTI)

The eruption of the Mount Asama volcano on 16 September 2004 produced an ash cloud and led to ashfall in the Tokyo metropolitan area that lies on the Kanto Plain. Satellite images showed the ash cloud drifting toward the south in the morning but ...

Nobumitsu Tsunematsu; Tomohiro Nagai; Toshiyuki Murayama; Ahoro Adachi; Yasuhiro Murayama

2008-04-01T23:59:59.000Z

95

Numerical Analysis on the Contribution of Urbanization to Wind Stilling: An Example over the Greater Beijing Metropolitan Area  

Science Conference Proceedings (OSTI)

A decline of surface wind speed (wind stilling) has been observed in many regions of the world. The greater Beijing metropolitan area in China is taken as an example for analyzing the urbanization impact on wind stilling. This study set up five ...

Aizhong Hou; Guangheng Ni; Hanbo Yang; Zhidong Lei

2013-05-01T23:59:59.000Z

96

The role of the phosphorus BIBII transition in proteinDNA recognition: the NF-kB complex  

E-Print Network (OSTI)

The role of the phosphorus BI±BII transition in protein±DNA recognition: the NF-kB complex K) containing the HIV-1 NF-kB-binding site, in which the sequences ¯anking the kB site had been mutated. 31P NMR of the BI±BII equilibrium in NF-kB recognition by DNA was then investigated by electrophoretic mobility

Paris-Sud XI, Université de

97

DEVELOPMENT OF THE REGIONAL INTELLIGENT TRANSPORTATION SYSTEMS ARCHITECTURE FOR THE SAN JUAN METROPOLITAN AREA Approved by:  

E-Print Network (OSTI)

Several regions around the United States and Puerto Rico have been facing increasingly complex problems related to their transportation systems. In many cases, the use of advanced technology and strategies collectively known as Intelligent Transportation Systems (ITS) have helped to substantially improve their transportation systems. The integration of all the ITS components in a framework is called the ITS system architecture and has usually been an important part of the success in improving the transportation system. This work presents the methodology followed to develop the regional ITS architecture for the San Juan Metropolitan Area. Initially, the region is described including the stakeholders group and identified needs. A description of user services, operational concepts and functional requirements is then presented. These steps lead to the presentation of the system architecture based upon the National ITS Architecture. At the end, the implications of the architecture in terms of planning and project development are discussed. i RESUMEN

María Isabel; Fernández González; Wilma Santiago

2006-01-01T23:59:59.000Z

98

Theoretical analyses predict A20 regulates period of NF-kB oscillation  

E-Print Network (OSTI)

The nuclear-cytoplasmic shuttling of NF-kB is characterized by damped oscillations of the nuclear concentration with a time period of around 1-2 hours. The NF-kB network contains several feedback loops modulating the overall response of NF-kB activity. While IkBa is known to drive and IkBe is known to dampen the oscillations, the precise role of A20 negative feedback remains to be elucidated. Here we propose a model of the NF-kB system focusing on three negative feedback loops (IkBa, IkBe and A20) which capture the experimentally observed responses in wild-type and knockout cells. We find that A20, like IkBe, efficiently dampens the oscillations albeit through a distinct mechanism. In addition, however, we have discovered a new functional role of A20 by which it controls the oscillation period of nuclear NF-kB. The design based on three nested feedback loops allows independent control of period and amplitude decay in the oscillatory response. Based on these results we predict that adjusting the expression lev...

Mengel, Benedicte; Jensen, Mogens H; Trusina, Ala

2009-01-01T23:59:59.000Z

99

Evolutionary Conserved Regulation of HIF-1b by NF-kB  

E-Print Network (OSTI)

Hypoxia Inducible Factor-1 (HIF-1) is essential for mammalian development and is the principal transcription factor activated by low oxygen tensions. HIF-a subunit quantities and their associated activity are regulated in a post-translational manner, through the concerted action of a class of enzymes called Prolyl Hydroxylases (PHDs) and Factor Inhibiting HIF (FIH) respectively. However, alternative modes of HIF-a regulation such as translation or transcription are under-investigated, and their importance has not been firmly established. Here, we demonstrate that NF-kB regulates the HIF pathway in a significant and evolutionary conserved manner. We demonstrate that NF-kB directly regulates HIF-1b mRNA and protein. In addition, we found that NF-kB–mediated changes in HIF-1b result in modulation of HIF-2a protein. HIF-1b overexpression can rescue HIF-2a protein levels following NF-kB depletion. Significantly, NF-kB regulates HIF-1b (tango) and HIF-a (sima) levels and activity (Hph/fatiga, ImpL3/ldha) in Drosophila, both in normoxia and hypoxia, indicating an evolutionary conserved mode of regulation. These results reveal a novel mechanism of HIF regulation, with impact in the development of

Patrick Van Uden; Niall S. Kenneth; Ryan Webster; H. Arno Müller; Sharon Mudie; Sonia Rocha

2010-01-01T23:59:59.000Z

100

Endocytosis-Independent Function of Clathrin Heavy Chain in the Control of Basal NF-kB Activation  

E-Print Network (OSTI)

Background: Nuclear factor-kB (NF-kB) is a transcription factor that regulates the transcription of genes involved in a variety of biological processes, including innate and adaptive immunity, stress responses and cell proliferation. Constitutive or excessive NF-kB activity has been associated with inflammatory disorders and higher risk of cancer. In contrast to the mechanisms controlling inducible activation, the regulation of basal NF-kB activation is not well understood. Here we test whether clathrin heavy chain (CHC) contributes to the regulation of basal NF-kB activity in epithelial cells. Methodology: Using RNA interference to reduce endogenous CHC expression, we found that CHC is required to prevent constitutive activation of NF-kB and gene expression. Immunofluorescence staining showed constitutive nuclear localization of the NF-kB subunit p65 in absence of stimulation after CHC knockdown. Elevated basal p65 nuclear localization is caused by constitutive phosphorylation and degradation of inhibitor of NF-kB alpha (IkBa) through an IkB kinase a (IKKa)-dependent mechanism. The role of CHC in NF-kB signaling is functionally relevant as constitutive expression of the proinflammatory chemokine interleukin-8 (IL-8), whose expression is regulated by NF-kB, was found after CHC knockdown. Disruption of clathrin-mediated endocytosis by chemical inhibition or depletion of the m2-subunit of the endocytosis adaptor protein AP-2, and knockdown of clathrin light chain a (CHLa), failed to induce constitutive NF-kB activation and IL-8 expression, showing that CHC acts on NF-kB independently of endocytosis and CLCa.

Man Lyang Kim; Isabel Sorg; Cécile Arrieumerlou

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Investigating the role of intra- and extra-cellular modulators of the transcription factor NF-kappaB  

E-Print Network (OSTI)

The nuclear factor-kappa B (NF-kappaB) family of transcription factors play a pivotal role in the inflammatory and immune responses, as well as cell growth and survival. Since its discovery 25 years ago, NF-kappaB has ...

Nguyen, Hung Nhat

2011-01-01T23:59:59.000Z

102

Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells  

Science Conference Proceedings (OSTI)

A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

Jian Li

2012-11-07T23:59:59.000Z

103

Simple Modifications to Improve Fifth-Generation Pennsylvania State University–National Center for Atmospheric Research Mesoscale Model Performance for the Phoenix, Arizona, Metropolitan Area  

Science Conference Proceedings (OSTI)

The diurnal temperature cycle in the Phoenix, Arizona, metropolitan area, as represented in the fifth-generation Pennsylvania State University–National Center for Atmospheric Research Mesoscale Model (MM5), is examined using a high-resolution 2-...

Joseph A. Zehnder

2002-09-01T23:59:59.000Z

104

Elevated Ozone Layers over the Seoul Metropolitan Region in Korea: Evidence for Long-Range Ozone Transport from Eastern China and Its Contribution to Surface Concentrations  

Science Conference Proceedings (OSTI)

Elevated layers of high ozone concentration were observed over the Seoul metropolitan region (SMR) in Korea by ozonesonde measurements during 6–9 June 2003. An analysis of the synoptic-scale meteorological features and backward trajectories ...

In-Bo Oh; Yoo-Keun Kim; Mi-Kyung Hwang; Cheol-Hee Kim; Soontae Kim; Sang-Keun Song

2010-02-01T23:59:59.000Z

105

NRP/Optineurin Cooperates with TAX1BP1 to Potentiate the Activation of NF-kB by Human T-Lymphotropic Virus  

E-Print Network (OSTI)

NRP/Optineurin Cooperates with TAX1BP1 to Potentiate the Activation of NF-kB by Human T Nuclear factor (NF)-kB is a major survival pathway engaged by the Human T-Lymphotropic Virus type 1 (HTLV-1) Tax protein. Tax1 activation of NF-kB occurs predominantly in the cytoplasm, where Tax1 binds NF-kB

Paris-Sud XI, Université de

106

Poxvirus Targeting of E3 Ligase b-TrCP by Molecular Mimicry: A Mechanism to Inhibit NF-kB Activation and  

E-Print Network (OSTI)

Poxvirus Targeting of E3 Ligase b-TrCP by Molecular Mimicry: A Mechanism to Inhibit NF-kB, Trinity College Dublin, Dublin, Ireland Abstract The transcription factor NF-kB is essential for immune degradation of IkBa. Here we describe an inhibitor of NF-kB from vaccinia virus that has a closely related

Utrecht, Universiteit

107

NF-kB activation by ultraviolet light not dependent on a nuclear signal  

Science Conference Proceedings (OSTI)

Exposure of mammalian cells to radiation triggers the ultraviolet (UV) response, which includes activation of activator protein-1 (AP-1) and nuclear factor kappa B (NF-kB). This was postulated to occur by induction of a nuclear signaling cascade by damaged DNA. Recently, induction of AP-1 by UV was shown to be mediated by a pathway involving Src tyrosine kinases and the Ha-Ras small guanosine triphosphate-binding protein, proteins located at the plasma membrane. It is demonstrated here that the same pathway mediates induction of NF-kB by UV. Because inactive NF-kB is stored in the cytosol, analysis of its activation directly tests the involvement of a nuclear-initiated signaling cascade. Enucleated cells are fully responsive to UV both in NF-kB induction and in activation of another key signaling event. Therefore, the UV response does not require a signal generated in the nucleus and is likely to be initiated at or near the plasma membrane.

Devary, Y.; Rosette, C.; DiDonato, J.A.; Karin, M. (Univ. of California, San Diego, CA (United States))

1993-09-10T23:59:59.000Z

108

Original article Induction of apoptosis and NF-B by quercetin  

E-Print Network (OSTI)

activity of NF-B, which may implicate an increasing resistance to their cytotoxicity. quercetin / TNF) Abstract -- Polyphenol quercetin induced apoptosis in proliferating murine L1210 lymphocytic cells. DNA promoting activity of quercetin was enhanced by physiological concentrations of TNF-. At the same time

Recanati, Catherine

109

IS NF-B A GOOD TARGET FOR CANCER THERAPY? HOPES AND PITFALLS  

E-Print Network (OSTI)

clear that aberrant regulation of NF-B and the signaling pathways that control its activity are involved and acquire drug resistance4, 5 . The current armamentarium of medical oncology includes many active, such as innate and adaptive immune responses, cell proliferation, cell death, and inflammation. It has become

Paris-Sud XI, Université de

110

Human papillomavirus type 16 E6 and E 7 proteins alter NF-kB in cultured cervical epithelial cells and inhibition of NF-kB promotes cell growth and immortalization  

Science Conference Proceedings (OSTI)

The NF-kB family of transcription factors regulates important biological functions including cell growth, survival and the immune response. We found that Human Papillomavirus type 16 (HPV-16) E7 and E6/E7 proteins inhibited basal and TNF-alpha-inducible NF-kB activity in human epithelial cells cultured from the cervical transformation zone, the anatomic region where most cervical cancers develop. In contrast, HPV-16 E6 regulated NF-kB in a cell type- and cell growth-dependent manner. NF-kB influenced immortalization of cervical cells by HPV16. Inhibition of NF-kB by an IkB alpha repressor mutant increased colony formation and immortalization by HPV-16. In contrast, activation of NF-kB by constitutive expression of p65 inhibited proliferation and immortalization. Our results suggest that inhibition of NF-kB by HPV-16 E6/E7 contributes to immortalization of cells from the cervical transformation zone.

Vandermark, Erik R.; Deluca, Krysta A.; Gardner, Courtney R.; Marker, Daniel F.; Schreiner, Cynthia N.; Strickland, David A.; Wilton, Katelynn M. [Department of Biology, Clarkson University, Potsdam, NY 13699-5805 (United States)] [Department of Biology, Clarkson University, Potsdam, NY 13699-5805 (United States); Mondal, Sumona [Department of Mathematics, Clarkson University, Potsdam, NY 13699-5805 (United States)] [Department of Mathematics, Clarkson University, Potsdam, NY 13699-5805 (United States); Woodworth, Craig D., E-mail: woodworth@clarkson.edu [Department of Biology, Clarkson University, Potsdam, NY 13699-5805 (United States)

2012-03-30T23:59:59.000Z

111

Purinergic Signaling is Required for Fluid Shear Stress-Induced NF-kB Translocation in Osteoblasts  

SciTech Connect

Fluid shear stress regulates gene expression in osteoblasts, in part by activation of the transcription factor NF-kB. We examined whether this process was under control of purinoceptor activation. MC3T3-E1 osteoblasts under static conditions expressed the NF-kB inhibitory protein IkB alpha and exhibited cytosolic localization of NF-kB. Under fluid shear stress, I?B? levels decreased, and concomitant nuclear localization of NF-kB was observed. Cells exposed to fluid shear stress in ATP-depleted medium exhibited no significant reduction in I?B?, and NF-kB remained within the cytosol. Similar results were found using oxidized ATP or Brilliant Blue G, P2X7 receptor antagonists, indicating that the P2X7 receptor is responsible for fluid shear-stress-induced I?B? degradation and nuclear accumulation of NF-kB. Pharmacologic blockage of the P2Y6 receptor also prevented shear-induced IkB alpha degradation. These phenomena involved neither ERK1/2 signaling nor autocrine activation by P2X7-generated lysophosphatidic acid. Our results suggest that fluid shear stress regulates NF-kB activity through the P2Y6 and P2X7 receptor.

Genetos, Damian C.; Karin, Norman J.; Geist, Derik J.; Donahue, Henry J.; Duncan, Randall L.

2011-04-01T23:59:59.000Z

112

Coal dust contiguity-induced changes in the concentration of TNF- and NF- B p65 on the ocular surface  

Science Conference Proceedings (OSTI)

To observe the influence of coal dust on ocular surface of coal miners and rabbits with coal dust contiguity on expression TNF- and NF- Bp65 and dry eye occurrence. Expression TNF- and NF- Bp65 in ocular surface were determined. Results showed tear production, BUT and lysozyme decreased for coal miners and rabbits with coal dust contiguity. Coal dust exposure was linked to development of xerophthalmia, and induced a higher expression of NF- B p65 and TNF- perhaps as a mechanism to resist coal dust ocular surface injury.

Sun, Z.Y.; Hong, J.; Liu, Z.Y.; Jin, X.D.; Gu, C.H. [China Medical University, Shenyang (China)

2009-07-01T23:59:59.000Z

113

Modeling the Dynamics of Desakota Regions: Global - Local Nexus in the Taipei Metropolitan Area  

E-Print Network (OSTI)

Since the 1970s, Asia has experienced rapid urbanization processes, which are distinct from U.S. society, and the direction of Asian urbanization is more strongly affected by economic globalization. The desakota model, proposed by McGee and Ginsburg in 1991, focuses on how internal domestic and local forces drive the specific rural-urban transformation in Asia. However, the McGee-Ginsburg model does not emphasize the importance of globalization on Asian urbanization. To fill the gap, this study develops a GIS-based CA framework based on the desakota model to not only simulate the unique urbanization processes in Asia but also integrate the influence of globalization into Asian urban dynamics. Three approaches are developed in the CA simulation: 1) physical constraints and land-use classification from remotely sensed images in 1993, 2000, and 2008, are incorporated into micro-scale transformation; 2) population dynamics, shifts of economic activities, and foreign direct investment (FDIs), a representative of the impact of globalization, are applied for multi-scale interconnection; 3) the Monte Carlo mechanism is finally introduced to combine the above two approaches and implement the simulation process. The Taipei metropolitan area, a rapid urbanizing region that highly interacts with the global economy in Asia, is chosen to examine this model. The CA simulation model establishes a strong interaction between FDIs, an indicator representing impacts of globalization, and the dazzling Asian urban model. The combination of multi-scale economic factors and micro-scale land-use transformation also reveals how urban growth of the Taipei metropolis in recent years fits the characterization of the desakota model, and how desakota regions, the growth generators, interact with city cores. As a result, the research not only successfully links the influence of globalization with the desakota model and simulates urban dynamics of Asian cities but also provides scenarios of different FDI inputs for governments to better handle urban growth with global impacts under the deep economic recession since 2007.

Wu, Bing-Sheng

2009-08-01T23:59:59.000Z

114

Cooling energy savings potential of light-colored roofs for residential and commercial buildings in 11 US metropolitan areas  

SciTech Connect

Light-colored roofs reflect more sunlight than dark roofs, thus they keep buildings cooler and reduce air-conditioning demand. Typical roofs in the United States are dark, which creates a potential for savings energy and money by changing to reflective roofs. In this report, the authors make quantitative estimates of the impact of roof color by simulating prototypical buildings with light- and dark-colored roofs and calculating savings by taking the differences in annual cooling and heating energy use, and peak electricity demand. Monetary savings are calculated using local utility rates. Savings are estimated for 11 U.S. Metropolitan Statistical Areas (MSAs) in a variety of climates.

Konopacki, S.; Akbari, H.; Pomerantz, M.; Gabersek, S.; Gartland, L.

1997-05-01T23:59:59.000Z

115

Agreement Execution Process Study: CRADAs and NF-WFO Agreements and the Speed of Business  

SciTech Connect

This report summarizes the findings of a study on the execution of Cooperative Research and Development Agreements (CRADAs) and Non-Federal Work for Others (NF-WFO) agreements across the U.S. Department of Energy (DOE) laboratory complex. The study provides quantitiative estimates of times required to negotiate and execute these agreements across the DOE complex. It identifies factors impacting on cycle times and describes best practicies used at various laboratories and site offices that reduce cycle times.

Harrer, Bruce J.; Cejka, Cheryl L.; Macklin, Richard; Miksovic, Ann

2011-02-01T23:59:59.000Z

116

IKKa and IKKb Each Function to Regulate NF-kB Activation in the TNF-Induced/Canonical Pathway  

E-Print Network (OSTI)

Background: Activation of the transcription factor NF-kB by cytokines is rapid, mediated through the activation of the IKK complex with subsequent phosphorylation and degradation of the inhibitory IkB proteins. The IKK complex is comprised of two catalytic subunits, IKKa and IKKb, and a regulatory protein known as NEMO. Using cells from mice that are genetically deficient in IKKb or IKKa, or using a kinase inactive mutant of IKKb, it has been proposed that IKKb is critical for TNF-induced IkB phosphorylation/degradation through the canonical pathway while IKKa has been shown to be involved in the noncanonical pathway for NF-kB activation. These conclusions have led to a focus on development of IKKb inhibitors for potential use in inflammatory disorders and cancer. Methodology: Analysis of NF-kB activation in response to TNF in MEFs reveals that IKKb is essential for efficient phosphorylation and subsequent degradation of IkBa, yet IKKa contributes to the NF-kB activation response in these cells as measured via DNA binding assays. In HeLa cells, both IKKa and IKKb contribute to IkBa phosphorylation and NF-kB activation. A kinase inactive mutant of IKKb, which has been used as evidence for the critical importance of IKKb in TNFinduced signaling, blocks activation of NF-kB induced by IKKa, even in cells that are deficient in IKKb. Conclusions: These results demonstrate the importance of IKKa in canonical NF-kB activation, downstream of cytokine

Mazhar Adli; Evan Merkhofer; Patricia Cogswell; Albert S. Baldwin

2009-01-01T23:59:59.000Z

117

TRIM30a negatively regulates TLR-mediated NF-jB activation by targeting TAB2 and TAB3 for degradation  

E-Print Network (OSTI)

of the transcription factor NF-kB and stress-activated protein kinases5 and then induces the expression of genes encoding immune and proinflammatory molecules6. Activation of NF-kB by a TLR signal depends on the activity of the inhibitor of NF-kB (IkB) kinase (IKK) complex. In turn, activation of both IKK and TAK1 (A002249

Tian, Weidong

118

Modeling urban growth and land use/land cover change in the Houston Metropolitan Area from 2002 - 2030  

E-Print Network (OSTI)

The Houston-Galveston-Brazoria Consolidated Metropolitan Statistical Area (Houston CMSA) has experienced rapid population growth during the past decades and is the only major US metropolitan area with no zoning regulations. We use SLEUTH, a spatially explicit cellular automata model, to simulate future (2002-2030) urban growth in the Houston metropolitan area, one of the fastest growing metropolises in the United States during the past decades. The model is calibrated with historical data for the period 1974-2002 that are extracted from a time series of satellite images. The dataset consists of four historical urban extents (1974, 1984, 1992, 2002), two land use layers (1992, 2002), five transportation layers (1974, 1984, 1990, 2002, 2025), slope layer, hillshade layer, and excluded layer. Future growth patterns are predicted based on growth coefficients derived during the calibration phase. After calibrating the model successfully, the spatial pattern of urban growth of the Houston CMSA for the period from 2002 to 2030 is predicted. Within SLEUTH, growth in the Houston CMSA is predominately "organic" with most growth occurring along the urban/rural fringe. Projected increases in urban area from 2002 to 2030 parallel projected increases in population growth within the Houston CMSA. We design three specific scenarios to simulate the spatial consequences of urban growth under different environmental conditions. The first scenario is to simulate the unmanaged growth with no restrictions. The second scenario is to project the moderate growth trend by taking into consideration environmental protection, specifically for agricultural areas, forests and wetlands. The last scenario is to simulate the managed growth with maximum environmental protection. Adjusting the level of protection for different land cover types was found to markedly affect the land use changes in the Houston CMSA. Without any protection on resource lands, Houston CMSA is estimated to lose 2,000 km2 of forest land by 2030, about 600 km2 of agricultural land, and approximately 400 km2 of wetland. Approximately half of all resource land could be saved by the third scenario, managed growth with maximum protection.

Oguz, Hakan

2003-05-01T23:59:59.000Z

119

XIAP Induces NF-kB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization  

Science Conference Proceedings (OSTI)

In addition to caspase inhibition, X-linked inhibitor of apoptosis (XIAP) induces NF-{kappa}B and MAP kinase activation during TGF-b and BMP receptor signaling and upon overexpression. Here we show that the BIR1 domain of XIAP, which has no previously ascribed function, directly interacts with TAB1 to induce NF-{kappa}B activation. TAB1 is an upstream adaptor for the activation of the kinase TAK1, which in turn couples to the NF-{kappa}B pathway. We report the crystal structures of BIR1, TAB1, and the BIR1/TAB1 complex. The BIR1/TAB1 structure reveals a striking butterfly-shaped dimer and the detailed interaction between BIR1 and TAB1. Structure-based mutagenesis and knockdown of TAB1 show unambiguously that the BIR1/TAB1 interaction is crucial for XIAP-induced TAK1 and NF-{kappa}B activation. We show that although not interacting with BIR1, Smac, the antagonist for caspase inhibition by XIAP, also inhibits the XIAP/TAB1 interaction. Disruption of BIR1 dimerization abolishes XIAP-mediated NF-{kappa}B activation, implicating a proximity-induced mechanism for TAK1 activation.

Lu,M.; Lin, S.; Huang, Y.; Kang, Y.; Rich, R.; Lo, Y.; Myszka, D.; Han, J.; Wu, H.

2007-01-01T23:59:59.000Z

120

Study of the temporal and spatial variation of climate and solar radiation in th metropolitan Phoenix area. Final technical progress report, July 1, 1977-June 30, 1978  

DOE Green Energy (OSTI)

The research performed was designed to identify spatial or temporal variation of any atmospheric parameters that might affect the operation of devices utilizing solar energy in the metropolitan Phoenix area. The first part of the research involved the analysis of all available solar and climatic data to determine their validity and comparability. For the standard climatic parameters, few difficulties were encountered, but the task of determining comparability of solar radiation data involved many pitfalls. It was concluded that most of the solar data acquired before January 1977 could not be used for purposes of identifying spatial variability. And, a year and a half of data does not represent a long enough period of time upon which to base sound conclusions about spatial and temporal variability of solar radiation in the metropolitan Phoenix region. The data currently available to us do not indicate any great variation of solar radiation in the metropolitan Phoenix area. However, any meaningful statements about spatial and temporal variability of solar radiation in the metropolitan Phoenix area must await the acquisition of additional data from well-calibrated equipment.

Durrenberger, R.W.

1978-09-29T23:59:59.000Z

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Effects of urban land cover modifications in a mesoscale meteorological model on surface temperature and heat fluxes in the Phoenix metropolitan area.  

E-Print Network (OSTI)

and latent heat fluxes and therefore the ground temperature, Tg. Evaporation, E, for each grid cell temperature and heat fluxes in the Phoenix metropolitan area. S. Grossman-Clarke1, J.A. Zehnder2, and W) satellite images [2]. The data were upscaled to a 30-second grid and used to augment and correct

Hall, Sharon J.

122

Contribution of Land Use Changes to Near-Surface Air Temperatures during Recent Summer Extreme Heat Events in the Phoenix Metropolitan Area  

Science Conference Proceedings (OSTI)

The impact of 1973–2005 land use–land cover (LULC) changes on near-surface air temperatures during four recent summer extreme heat events (EHEs) are investigated for the arid Phoenix, Arizona, metropolitan area using the Weather Research and ...

Susanne Grossman-Clarke; Joseph A. Zehnder; Thomas Loridan; C. Sue B. Grimmond

2010-08-01T23:59:59.000Z

123

Effects of Regional Warming due to Urbanization on Daytime Local Circulations in a Complex Basin of the Daegu Metropolitan Area, Korea  

Science Conference Proceedings (OSTI)

Numerical and observational analyses were conducted using realistic and historical three-set land-use data over 40 yr from 1963 to 2002 to evaluate regional warming in the Daegu metropolitan area due to dramatic land-use alterations in the basin ...

Soon-Hwan Lee; Hae-Dong Kim

2008-05-01T23:59:59.000Z

124

The Enteropathogenic E. coli (EPEC) Tir Effector Inhibits NF-kB Activity by Targeting TNFa Receptor-Associated Factors  

E-Print Network (OSTI)

Enteropathogenic Escherichia coli (EPEC) disease depends on the transfer of effector proteins into epithelia lining the human small intestine. EPEC E2348/69 has at least 20 effector genes of which six are located with the effector-delivery system genes on the Locus of Enterocyte Effacement (LEE) Pathogenicity Island. Our previous work implied that non-LEE-encoded (Nle) effectors possess functions that inhibit epithelial anti-microbial and inflammation-inducing responses by blocking NF-kB transcription factor activity. Indeed, screens by us and others have identified novel inhibitory mechanisms for NleC and NleH, with key co-operative functions for NleB1 and NleE1. Here, we demonstrate that the LEE-encoded Translocatedintimin receptor (Tir) effector has a potent and specific ability to inhibit NF-kB activation. Indeed, biochemical, imaging and immunoprecipitation studies reveal a novel inhibitory mechanism whereby Tir interaction with cytoplasm-located TNFa receptor-associated factor (TRAF) adaptor proteins induces their proteasomal-independent degradation. Infection studies support this Tir-TRAF relationship but reveal that Tir, like NleC and NleH, has a non-essential contribution in EPEC’s NF-kB inhibitory capacity linked to Tir’s activity being suppressed by undefined EPEC factors. Infections in a disease-relevant intestinal model confirm key NF-kB inhibitory roles for the NleB1/NleE1 effectors, with other studies providing insights on host targets. The work not only reveals a second Intimin-independent property for Tir and a novel EPEC effector-mediated NF-kB inhibitory mechanism but also lends itself to speculations on the evolution of EPEC’s capacity to inhibit NF-kB

Marie-hélène Ruchaud-sparagano; Sabrina Mühlen; Paul Dean; Brendan Kenny

2011-01-01T23:59:59.000Z

125

Introducing Spatial Information into Predictive NF-kB Modelling – An Agent-Based Approach  

E-Print Network (OSTI)

Nature is governed by local interactions among lower-level sub-units, whether at the cell, organ, organism, or colony level. Adaptive system behaviour emerges via these interactions, which integrate the activity of the sub-units. To understand the system level it is necessary to understand the underlying local interactions. Successful models of local interactions at different levels of biological organisation, including epithelial tissue and ant colonies, have demonstrated the benefits of such ‘agent-based ’ modelling [1–4]. Here we present an agent-based approach to modelling a crucial biological system – the intracellular NF-kB signalling pathway. The pathway is vital to immune response regulation, and is fundamental to basic survival in a range of species [5–7]. Alterations in pathway regulation underlie a variety of diseases, including atherosclerosis and arthritis. Our modelling of individual molecules, receptors and genes provides a more comprehensive outline of regulatory network mechanisms than previously possible with equation-based approaches [8]. The method also permits consideration of structural parameters in pathway regulation; here we predict that inhibition of NF-kB is directly affected by actin filaments of the cytoskeleton sequestering excess inhibitors, therefore regulating steady-state and feedback

Mark Pogson; Mike Holcombe; Rod Smallwood; Eva Qwarnstrom

2008-01-01T23:59:59.000Z

126

The Surface Activation Layer of GaAs Negative Electron Affinity Photocathode Activated by Cs, Li and NF3  

Science Conference Proceedings (OSTI)

The lifetime of GaAs photocathodes can be greatly improved by introducing Li in the Cs+NF{sub 3} activation process. The surface activation layer of such photocathodes is studied by synchrotron radiation photoemission and is compared with GaAs photocathodes activated without Li. The charge distributions of N, F and Cs experience significant changes when Li is added in the activation. In addition, the presence of Li causes NF{sub x} molecules to take an orientation with F atoms on top. All these changes induced by Li hold the key for the lifetime improvement of GaAs photocathodes.

Sun, Yun; /SLAC, SSRL; Kirby, R.E.; /Saxet Surface Sci.; Maruyama, T.; /SLAC; Mulhollan, G.A.; Bierman, J.C.; /Saxet Surface Sci.; Pianetta, P.; /SLAC, SSRL

2009-12-11T23:59:59.000Z

127

The TCL1A Oncoprotein Interacts Directly with the NF-kB Inhibitor IkB  

E-Print Network (OSTI)

The T cell leukaemia/lymphoma 1A (TCL1A) oncoprotein plays key roles in several B and T cell malignancies. Lacking enzymatic activity, TCL1A’s transforming action was linked to its capacity to co-activate the protein kinase AKT via binding to its pleckstrin homology (PH) domain. However, perturbation of AKT signalling alone was recently shown insufficient to explain TCL1A oncogenesis, suggesting that TCL1A has additional cellular partners. Searching for such additional targets, we found that TCL1A binds specifically and directly to the ankyrin domain of IkB, the inhibitor of the NF-kB transcription factors. Through binding assays and a structural analysis by small angle X-ray scattering, we show that TCL1A and IkB interact in yeast-two-hybrid systems, when transiently overexpressed in 293 cells, and as recombinant proteins in vitro. We further establish that the association between TCL1A and IkB is compatible with AKT binding to TCL1A, but incompatible with IkB binding to NF-kB. By interfering with the inhibition of NF-kB byIkB, TCL1A may increase the concentration of free NF-kB molecules sufficiently to trigger expression of anti-apoptotic genes. Thus our data suggest an additional route by

Virginie Ropars; Gilles Despouy; Marc-henri Stern; Serge Benichou; Stefan T. Arold

2009-01-01T23:59:59.000Z

128

Nat Rev Drug Discov. Author manuscript Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls  

E-Print Network (OSTI)

and the signaling pathways that control its activity are involved in cancer development and progression, as well resistance , .4 5 The current armamentarium of medical oncology includes many active anticancer agents, cell proliferation, cell death, and inflammation. It has become clear that aberrant regulation of NF- B

Paris-Sud XI, Université de

129

Towards thermodynamics with $N_f=2+1+1$ twisted mass quarks  

E-Print Network (OSTI)

We present preliminary results achieved within a recently started project dealing with QCD thermodynamics in the presence of a fully dynamical second quark family. We are employing the Wilson twisted mass discretization. To reduce the amount of zero temperature simulations and the cost of analysis we have chosen the fixed-scale approach. We show a variety of basic thermodynamic observables for temperatures ranging from 158 to 633 MeV. Simulations were performed for three lattice spacings below 0.1 fm each and at a single value of the pion mass which allows a comparison with previously obtained $N_f=2$ results. We determine the chiral crossover temperature from the bare chiral susceptibility and show results for the gauge part of the trace anomaly.

Florian Burger; Grit Hotzel; Michael Müller-Preussker; Ernst-Michael Ilgenfritz; Maria Paola Lombardo

2013-11-07T23:59:59.000Z

130

Determining the conformal window: SU(2) gauge theory with N_f = 4, 6 and 10 fermion flavours  

E-Print Network (OSTI)

We study the evolution of the coupling in SU(2) gauge field theory with $N_f=4$, 6 and 10 fundamental fermion flavours on the lattice. These values are chosen close to the expected edges of the conformal window, where the theory possesses an infrared fixed point. We use improved Wilson-clover action, and measure the coupling in the Schr\\"odinger functional scheme. At four flavours we observe that the couping grows towards the infrared, implying QCD-like behaviour, whereas at ten flavours the results are compatible with a Banks-Zaks type infrared fixed point. The six flavour case remains inconclusive: the evolution of the coupling is seen to become slower at the infrared, but the accuracy of the results falls short from fully resolving the fate of the coupling. We also measure the mass anomalous dimension for the $N_f=6$ case.

Tuomas Karavirta; Jarno Rantaharju; Kari Rummukainen; Kimmo Tuominen

2011-11-17T23:59:59.000Z

131

Cooling energy savings potential of light-colored roofs for residential and commercial buildings in 11 US metropolitan areas  

SciTech Connect

The U.S. Environmental Protection Agency (EPA) sponsored this project to estimate potential energy and monetary savings resulting from the implementation of light-colored roofs on residential and commercial buildings in major U.S. metropolitan areas. Light-colored roofs reflect more sunlight than dark roofs, so they keep buildings cooler and reduce air-conditioning demand. Typically, rooftops in the United States are dark, and thus there is a potential for saving energy and money by changing to reflective roofs. Naturally, the expected savings are higher in southern, sunny, and cloudless climates. In this study, we make quantitative estimates of reduction in peak power demand and annual cooling electricity use that would result from increasing the reflectivity of the roofs. Since light-colored roofs also reflect heat in the winter, the estimates of annual electricity savings are a net value corrected for the increased wintertime energy use. Savings estimates only include direct reduction in building energy use and do not account for the indirect benefit that would also occur from the reduction in ambient temperature, i.e. a reduction in the heat island effect. This analysis is based on simulations of building energy use, using the DOE-2 building energy simulation program. Our methodology starts with specifying 11 prototypical buildings: single-family residential (old and new), office (old and new), retail store (old and new), school (primary and secondary), health (hospital and nursing home), and grocery store. Most prototypes are simulated with two heating systems: gas furnace and heat pumps. We then perform DOE-2 simulations of the prototypical buildings, with light and dark roofs, in a variety of climates and obtain estimates of the energy use for air conditioning and heating.

Konopacki, S.; Akbari, H.; Gartland, L. [and others

1997-05-01T23:59:59.000Z

132

KT McDonald IDS-NF Plenary Meeting (RAL) Apr 6, 20132 1 Engineering Issues for the  

E-Print Network (OSTI)

Diagnostics Controls and Interlocks Health and Safety Mechanical Decommissioning Remote Handling and Hot Cells 10,730,099 1.06.07 - Remote Handling Systems 14,348,362 1.06.08 - Controls 3,076,899 1.06.09 - Beam. #12;KT McDonald IDS-NF Plenary Meeting (RAL) Apr 6, 20132 19 We must have an activated-air handling

McDonald, Kirk

133

GEF-H1 Mediated Control of NOD1 Dependent NF-kB Activation by Shigella Effectors  

E-Print Network (OSTI)

Shigella flexneri has evolved the ability to modify host cell function with intracellular active effectors to overcome the intestinal barrier. The detection of these microbial effectors and the initiation of innate immune responses are critical for rapid mucosal defense activation. The guanine nucleotide exchange factor H1 (GEF-H1) mediates RhoA activation required for cell invasion by the enteroinvasive pathogen Shigella flexneri. Surprisingly, GEF-H1 is requisite for NF-kB activation in response to Shigella infection. GEF-H1 interacts with NOD1 and is required for RIP2 dependent NF-kB activation by H-Ala-DcGlu-DAP (cTriDAP). GEF-H1 is essential for NF-kB activation by the Shigella effectors IpgB2 and OspB, which were found to signal in a NOD1 and RhoA Kinase (ROCK) dependent manner. Our results demonstrate that GEF-H1 is a critical component of cellular defenses forming an intracellular sensing system with NOD1 for the detection of microbial effectors during cell

Atsuko Fukazawa; Carmen Alonso; Kiyotaka Kurachi; Sonal Gupta; Cammie F. Lesser; Beth Ann; Hans-christian Reinecker

2008-01-01T23:59:59.000Z

134

Dual Delayed Feedback Provides Sensitivity and Robustness to the NF-kB Signaling Module  

E-Print Network (OSTI)

Many cellular stress-responsive signaling systems exhibit highly dynamic behavior with oscillatory features mediated by delayed negative feedback loops. What remains unclear is whether oscillatory behavior is the basis for a signaling code based on frequency modulation (FM) or whether the negative feedback control modules have evolved to fulfill other functional requirements. Here, we use experimentally calibrated computational models to interrogate the negative feedback loops that regulate the dynamic activity of the transcription factor NF-kB. Linear stability analysis of the model shows that oscillatory frequency is a hard-wired feature of the primary negative feedback loop and not a function of the stimulus, thus arguing against an FM signaling code. Instead, our modeling studies suggest that the two feedback loops may be tuned to provide for rapid activation and inactivation capabilities for transient input signals of a wide range of durations; by minimizing late phase oscillations response durations may be fine-tuned in a graded rather than quantized manner. Further, in the presence of molecular noise the dual delayed negative feedback system minimizes stochastic

Diane M. Longo; Jangir Selimkhanov; Jeffrey D. Kearns; Jeff Hasty; Er Hoffmann; Lev S. Tsimring

2013-01-01T23:59:59.000Z

135

NF-kB Hyper-Activation by HTLV-1 Tax Induces Cellular Senescence, but Can Be Alleviated by the Viral Anti- Sense Protein HBZ  

E-Print Network (OSTI)

Activation of I-kB kinases (IKKs) and NF-kB by the human T lymphotropic virus type 1 (HTLV-1) trans-activator/oncoprotein, Tax, is thought to promote cell proliferation and transformation. Paradoxically, expression of Tax in most cells leads to drastic up-regulation of cyclin-dependent kinase inhibitors, p21 CIP1/WAF1 and p27 KIP1, which cause p53-/pRb-independent cellular senescence. Here we demonstrate that p21 CIP1/WAF1-/p27 KIP1-mediated senescence constitutes a checkpoint against IKK/NF-kB hyper-activation. Senescence induced by Tax in HeLa cells is attenuated by mutations in Tax that reduce IKK/NFkB activation and prevented by blocking NF-kB using a degradation-resistant mutant of I-kBa despite constitutive IKK activation. Small hairpin RNA-mediated knockdown indicates that RelA induces this senescence program by acting upstream of the anaphase promoting complex and RelB to stabilize p27 KIP1 protein and p21 CIP1/WAF1 mRNA respectively. Finally, we show that down-regulation of NF-kB by the HTLV-1 anti-sense protein, HBZ, delay or prevent the onset of Taxinduced senescence. We propose that the balance between Tax and HBZ expression determines the outcome of HTLV-1 infection. Robust HTLV-1 replication and elevated Tax expression drive IKK/NF-kB hyper-activation and trigger senescence. HBZ, however, modulates Tax-mediated viral replication and NF-kB activation, thus allowing HTLV-1-infected cells to proliferate, persist, and evolve. Finally, inactivation of the senescence checkpoint can facilitate persistent NF-kB activation

Huijun Zhi; Liangpeng Yang; Yu-liang Kuo; Yik-khuan Ho; Hsiu-ming Shih; Chou-zen Giam

2011-01-01T23:59:59.000Z

136

Non-Canonical NF-kB Activation and Abnormal B Cell Accumulation in Mice Expressing Ubiquitin Protein Ligase-Inactive c-IAP2  

E-Print Network (OSTI)

Chromosomal translocations between loci encoding MALT1 and c-IAP2 are common in MALT lymphomas. The resulting fusion proteins lack the c-IAP2 RING domain, the region responsible for its ubiquitin protein ligase (E3) activity. Ectopic expression of the fusion protein activates the canonical NF-kB signaling cascade, but how it does so is controversial and how it promotes MALT lymphoma is unknown. Considering recent reports implicating c-IAP1 and c-IAP2 E3 activity in repression of non-canonical NF-kB signaling, we asked if the c-IAP2/MALT fusion protein can initiate non-canonical NF-kB activation. Here we show that in addition to canonical activation, the fusion protein stabilizes NIK and activates noncanonical NF-kB. Canonical but not non-canonical activation depended on MALT1 paracaspase activity, and expression of E3-inactive c-IAP2 activated non-canonical NF-kB. Mice in which endogenous c-IAP2 was replaced with an E3-inactive mutant accumulated abnormal B cells with elevated non-canonical NF-kB and had increased numbers of B cells with a marginal zone phenotype, gut-associated lymphoid hyperplasia, and other features of MALT lymphoma. Thus, the c-IAP2/ MALT1 fusion protein activates NF-kB by two distinct mechanisms, and loss of c-IAP2 E3 activity in vivo is sufficient to induce abnormalities common to MALT lymphoma.

Dietrich B. Conze; Yongge Zhao; Jonathan D. Ashwell

2010-01-01T23:59:59.000Z

137

Dual mechanisms of NF-kappaB inhibition in carnosol-treated endothelial cells  

Science Conference Proceedings (OSTI)

The increased adhesion of monocytes to injured endothelial layers is a critical early event in atherogenesis. Under inflammatory conditions, there is increased expression of specific cell adhesion molecules on activated vascular endothelial cells, which increases monocyte adhesion. In our current study, we demonstrate a putative mechanism for the anti-inflammatory effects of carnosol, a diterpene derived from the herb rosemary. Our results show that both carnosol and rosemary essential oils inhibit the adhesion of TNFalpha-induced monocytes to endothelial cells and suppress the expression of ICAM-1 at the transcriptional level. Moreover, carnosol was found to exert its inhibitory effects by blocking the degradation of the inhibitory protein IkappaBalpha in short term pretreatments but not in 12 h pretreatments. Our data show that carnosol reduces IKK-beta phosphorylation in pretreatments of less than 3 h. In TNFalpha-treated ECs, NF-kappaB nuclear translocation and transcriptional activity was abolished by up to 12 h of carnosol pretreatment and this was blocked by Nrf-2 siRNA. The long-term inhibitory effects of carnosol thus appear to be mediated through its induction of Nrf-2-related genes. The inhibition of ICAM-1 expression and p65 translocation is reversed by HO-1 siRNA. Carnosol also upregulates the Nrf-2-related glutathione synthase gene and thereby increases the GSH levels after 9 h of exposure. Treating ECs with a GSH synthesis inhibitor, BSO, blocks the inhibitory effects of carnosol. In addition, carnosol increases p65 glutathionylation. Hence, our present findings indicate that carnosol suppresses TNFalpha-induced singling pathways through the inhibition of IKK-beta activity or the upregulation of HO-1 expression. The resulting GSH levels are dependent, however, on the length of the carnosol pretreatment period.

Lian, K.-C.; Chuang, J.-J.; Hsieh, C.-W. [Department of Microbiology and Immunology, National Chiayi University, Chiayi, Taiwan (China); Wung, B.-S., E-mail: bswung@mail.ncyu.edu.t [Department of Microbiology and Immunology, National Chiayi University, Chiayi, Taiwan (China); Huang, G.-D.; Jian, T.-Y. [Department of Microbiology and Immunology, National Chiayi University, Chiayi, Taiwan (China); Sun, Y.-W. [Department of Biotechnology, Seed Improvement and Propagation Station, Taichung, Taiwan (China)

2010-05-15T23:59:59.000Z

138

Metropolitan Washington Council of Governments National Capital Region Transportation Planning Board Summary of the State of the Practice and State of the Art of Modeling Peak Spreading  

E-Print Network (OSTI)

Traffic congestion in large metropolitan areas has become so acute that many commuters are adjusting their departure and/or arrival times for work and other destinations to avoid the worst of what is now called the “peak period”. The adjustments in departure times combined with travel times that can last beyond the peak hour have led to the phenomena of peak spreading, where the peak hour demand on a particular roadway exceeds the peak hour capacity and causes demand to shift to the “shoulders ” of the peak hour, or the hours adjacent to the peak hour. This situation is so pronounced in the TPB region, that most of the major freeways in the areas have peak periods that last from roughly 6 AM to 10 AM in the morning and 3 PM to 7 PM in the evening where stop and go traffic is common throughout. The Metropolitan Washington Council of Governments, National Capital Region Transportation Planning Board (TPB) engaged Vanasse Hangen Brustlin (VHB) to review and summarize the state of the practice and the state of the art with regards to modeling peak spreading at the MPO level. VHB began this effort by reviewing the recent MPO survey and following up with staff at large MPOs with characteristics similar

unknown authors

2007-01-01T23:59:59.000Z

139

Characterization of Fine Particulate Matter (PM) and Secondary PM Precursor Gases in the Mexico City Metropolitan Area  

SciTech Connect

This project was one of three collaborating grants funded by DOE/ASP to characterize the fine particulate matter (PM) and secondary PM precursors in the Mexico City Metropolitan Area (MCMA) during the MILAGRO Campaign. The overall effort of MCMA-2006, one of the four components, focused on i) examination of the primary emissions of fine particles and precursor gases leading to photochemical production of atmospheric oxidants and secondary aerosol particles; ii) measurement and analysis of secondary oxidants and secondary fine PM production, with particular emphasis on secondary organic aerosol (SOA), and iii) evaluation of the photochemical and meteorological processes characteristic of the Mexico City Basin. The collaborative teams pursued the goals through three main tasks: i) analyses of fine PM and secondary PM precursor gaseous species data taken during the MCMA-2002/2003 campaigns and preparation of publications; ii) planning of the MILAGRO Campaign and deployment of the instrument around the MCMA; and iii) analysis of MCMA-2006 data and publication preparation. The measurement phase of the MILAGRO Campaign was successfully completed in March 2006 with excellent participation from the international scientific community and outstanding cooperation from the Mexican government agencies and institutions. The project reported here was led by the Massachusetts Institute of Technology/Molina Center for Energy and the Environment (MIT/MCE2) team and coordinated with DOE/ASP-funded collaborators at Aerodyne Research Inc., University of Colorado at Boulder and Montana State University. Currently 24 papers documenting the findings from this project have been published. The results from the project have improved significantly our understanding of the meteorological and photochemical processes contributing to the formation of ozone, secondary aerosols and other pollutants. Key findings from the MCMA-2003 include a vastly improved speciated emissions inventory from on-road vehicles: the MCMA motor vehicles produce abundant amounts of primary PM, elemental carbon, particle-bound polycyclic aromatic hydrocarbons, carbon monoxide and a wide range of air toxics; the feasibility of using eddy covariance techniques to measure fluxes of volatile organic compounds in an urban core and a valuable tool for validating local emissions inventory; a much better understanding of the sources and atmospheric loadings of volatile organic compounds; the first spectroscopic detection of glyoxal in the atmosphere; a unique analysis of the high fraction of ambient formaldehyde from primary emission sources; characterization of ozone formation and its sensitivity to VOCs and NOx; a much more extensive knowledge of the composition, size distribution and atmospheric mass loadings of both primary and secondary fine PM, including the fact that the rate of MCMA SOA production greatly exceeded that predicted by current atmospheric models; evaluations of significant errors that can arise from standard air quality monitors for O3 and NO2; and the implementation of an innovative Markov Chain Monte Carlo method for inorganic aerosol modeling as a powerful tool to analyze aerosol data and predict gas phase concentrations where these are unavailable. During the MILAGRO Campaign the collaborative team utilized a combination of central fixed sites and a mobile laboratory deployed throughout the MCMA to representative urban and boundary sites to measure trace gases and fine particles. Analysis of the extensive 2006 data sets has confirmed the key findings from MCMA-2002/2003; additionally MCMA-2006 provided more detailed gas and aerosol chemistry and wider regional scale coverage. Key results include an updated 2006 emissions inventory; extension of the flux system to measure fluxes of fine particles; better understanding of the sources and apportionment of aerosols, including contribution from biomass burning and industrial sources; a comprehensive evaluation of metal containing particles in a complex urban environment; identification of a close correlation between

Luisa T. Molina, Rainer Volkamer, Benjamin de Foy, Wenfang Lei, Miguel Zavala, Erik Velasco; Mario J. Molina

2008-10-31T23:59:59.000Z

140

Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling  

SciTech Connect

SET domain containing 6 (SETD6) monomethylates the RelA subunit of nuclear factor kappa B (NF-{kappa}B). The ankyrin repeats of G9a-like protein (GLP) recognizes RelA monomethylated at Lys310. Adjacent to Lys310 is Ser311, a known phosphorylation site of RelA. Ser311 phosphorylation inhibits Lys310 methylation by SETD6 as well as binding of Lys310me1 by GLP. The structure of SETD6 in complex with RelA peptide containing the methylation site, in the presence of S-adenosyl-l-methionine, reveals a V-like protein structure and suggests a model for NF-{kappa}B binding to SETD6. In addition, structural modeling of the GLP ankyrin repeats bound to Lys310me1 peptide provides insight into the molecular basis for inhibition of Lys310me1 binding by Ser311 phosphorylation. Together, these findings provide a structural explanation for a key cellular signaling pathway centered on RelA Lys310 methylation, which is generated by SETD6 and recognized by GLP, and incorporate a methylation-phosphorylation switch of adjacent lysine and serine residues. Finally, SETD6 is structurally similar to the Rubisco large subunit methyltransferase. Given the restriction of Rubisco to plant species, this particular appearance of the protein lysine methyltransferase has been evolutionarily well conserved.

Chang, Yanqi; Levy, Dan; Horton, John R.; Peng, Junmin; Zhang, Xing; Gozani, Or; Cheng, Xiaodong (Emory-MED); (Stanford)

2011-10-10T23:59:59.000Z

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141

Regulation of cytochrome P450 3A4 gene expression through modulating pregnane X receptor transcriptional activity by NF-? aryl hydrocarbon receptor and xenobiotics  

E-Print Network (OSTI)

Cytochrome P450 3A4 (CYP3A4) is a key enzyme responsible for the metabolism of drugs and endogenous compounds in human liver and intestine. CYP3A4 gene expression is mainly regulated by Pregnane X receptor (PXR) which is a ligand-dependent nuclear receptor. It is a long-standing observation that inflammatory responses and infections decrease drug metabolism capacity in human and experimental animals. In this study, I reported that NF-?B activation by LPS and TNF-? plays a pivotal role in the suppression of CYP3A4 through interactions of NF-?B with PXR/RXR complex. Inhibition of NF-?B by NF-?B specific suppressor SRI?B? reversed the suppressive effects of LPS and TNF-?. Furthermore, I showed that NF-?B p65 disrupted the association of PXR/RXR? complex with DNA sequences as determined by EMSA and chromatin immunoprecipitation assays. NF-?B p65 directly interacted with DNA binding domain of RXR? and DNA binding domain, hinge domain and ligand-binding domain of PXR and may prevent its binding to the consensus DNA sequences, thus inhibiting the transactivation by PXR/RXR? complex. This mechanism of suppression by NF-?B activation may be extended to other nuclear receptor-regulated systems where RXR? is a dimerization partner. Many genes regulated by PXR and AhR are important for phase I, II and III drug metabolism. In this study I reported a crosstalk between PXR and AhR pathways. AhR physically and functionally interacted with PXR and enhanced the PXR transcriptional activity, and the interaction repressed the AhR transcriptional activity. AhR also physically interacted with RXR?. The synergistic induction of Gsta1 in the liver of mice by PCN and TCDD might assume a different mechanism. The results suggested the metabolism kinetics of mixture drugs was different from and more complicated than that of single compound. Using a HepG2 cell-based PXR-driven CYP3A4-Luciferase assay, I reported that E/F domain of PXR was responsible for ligand-dependant activation. A/B domain was necessary for co-activating the ligand-dependent activation and D domain was suppressive. High doses of Valerian Root extraction were PXR-dependent CYP3A4 inducers. Green tea polyphenols, aflatoxin B1, CuSO4 and MnCl2 enhanced the PXR transcription activity activated by rifampicin. The results suggested PXR-mediated drug metabolism kinetics altered on xenobiotic exposure.

Gu, Xinsheng

2007-08-01T23:59:59.000Z

142

Effect of phenobarbital on hepatic cell proliferation and apoptosis in mice deficient in the p50 subunit of NF-{kappa}B  

Science Conference Proceedings (OSTI)

Phenobarbital (PB) is a nongenotoxic tumor promoter in the liver. One mechanism by which PB may exert its tumor promoting activity is by inducing oxidative stress. We previously found that PB administration increased hepatic NF-{kappa}B DNA binding activity. In this study we examined the hypothesis that the effects of PB on cell proliferation and apoptosis are dependent on NF-{kappa}B. We used a mouse model that is deficient in the p50 subunit of NF-{kappa}B; previous studies had found that p50-/- mice were less sensitive to the induction of hepatic cell proliferation by PCBs or peroxisome proliferators. Mice (p50-/- and wild-type B6129) were fed a control diet or one containing 0.05% PB for 3, 10 or 34 days. At the end of the experiment, the mice were euthanized and livers removed and processed. PB increased cell proliferation at 3 and 10 days (but not at 34 days), but the deletion of the NF-{kappa}B p50 subunit did not inhibit these increases. p50-/- Mice had higher cell proliferation at the 3 day (only in mice fed PB) and 34-day timepoints. PB decreased hepatocyte apoptosis after 3 days, slightly decreased it after 10 days, and did not affect it after 34 days. The deletion of the NF-{kappa}B p50 subunit did not influence PB's effect on apoptosis. In p50-/- mice, apoptosis was increased after 3 or 10 days compared to wild-type mice, but no effect was seen after 34 days. The hepatic expression of the NF-{kappa}B-regulated gene TNF-{alpha} correlated more with the hepatic cell proliferation data than with hepatic apoptosis, and was not decreased by the deletion of the p50 subunit. These findings show that the p50 subunit of NF-{kappa}B is not required for the alteration of hepatocyte proliferation or apoptosis by PB up to 34 days after its administration.

Tharappel, Job C. [Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky (United States); Spear, Brett T. [Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky (United States); Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky (United States); Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (United States); Glauert, Howard P. [Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky (United States); Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (United States)], E-mail: hglauert@uky.edu

2008-02-01T23:59:59.000Z

143

Artemisolide is a typical inhibitor of I{kappa}B kinase {beta} targeting cysteine-179 residue and down-regulates NF-{kappa}B-dependent TNF-{alpha} expression in LPS-activated macrophages  

SciTech Connect

Nuclear factor (NF)-{kappa}B regulates a central common signaling for immunity and cell survival. Artemisolide (ATM) was previously isolated as a NF-{kappa}B inhibitor from a plant of Artemisia asiatica. However, molecular basis of ATM on NF-{kappa}B activation remains to be defined. Here, we demonstrate that ATM is a typical inhibitor of I{kappa}B kinase {beta} (IKK{beta}), resulting in inhibition of lipopolysaccharide (LPS)-induced NF-{kappa}B activation in RAW 264.7 macrophages. ATM inhibited the kinase activity of highly purified IKK{beta} and also LPS-induced IKK activity in the cells. Moreover, the effect of ATM on IKK{beta} activity was completely abolished by substitution of Cys-179 residue of IKK{beta} to Ala residue, indicating direct targeting site of ATM. ATM could inhibit I{kappa}B{alpha} phosphorylation in LPS-activated RAW 264.7 cells and subsequently prevent NF-{kappa}B activation. Further, we demonstrate that ATM down-regulates NF-{kappa}B-dependent TNF-{alpha} expression. Taken together, this study provides a pharmacological potential of ATM in NF-{kappa}B-dependent inflammatory disorders.

Kim, Byung Hak; Lee, Jun-Young; Seo, Jee Hee; Lee, Hwa Young [College of Pharmacy, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Ryu, Shi Yong [Korea Research Institute of Chemical Technology, Taejon 305-600 (Korea, Republic of); Ahn, Byung Woo [College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Lee, Chong-Kil; Hwang, Bang Yeon; Han, Sang-Bae [College of Pharmacy, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Kim, Youngsoo [College of Pharmacy, Chungbuk National University, Cheongju 361-763 (Korea, Republic of)], E-mail: youngsoo@chungbuk.ac.kr

2007-09-28T23:59:59.000Z

144

$K$ and $D$ oscillations in the Standard Model and its extensions from $N_f=2+1+1$ Twisted Mass LQCD  

E-Print Network (OSTI)

We present the first $N_f=2+1+1$ results for the matrix elements of the operators describing neutral $K$ and $D$ mixing in the Standard Model and its extensions. The combination of maximally twisted sea quarks and Osterwalder-Seiler valence quarks ensures $\\mathcal{O}(a)$-improvement and continuum like renormalization pattern. We have used the $N_f=2+1+1$ dynamical quark gauge configurations generated by ETMC. Simulations include three lattice spacings in the interval $[0.06:0.09]$ fm and pseudoscalar meson masses in the range $[230:500]$ MeV. Our results are extrapolated to the continuum limit and to the physical quark masses. The calculation of the renormalization constants has been performed non-perturbatively in the RI-MOM scheme.

Carrasco, Nuria; Frezzotti, Roberto; Giménez, Vicent; Lubicz, Vittorio; Rossi, Giancarlo; Sanfilippo, Francesco; Tarantino, Cecilia

2013-01-01T23:59:59.000Z

145

The human NFKB3 gene encoding the p65 subunit of transcription factor NF-[sub K]B is located on chromosome 11q12  

SciTech Connect

A YAC clone that contains the human gene NFKB3, encoding the p65 subunit of transcription factor nuclear factor [sub K]B (NF-[sub K]B), was isolated. The YAC contains the entire NFKB3 gene, which is smaller than 15 kb and present in a single copy in the genome. Fluorescence in situ hybridization with metaphase chromosomes showed two different chromosomal locations (11q12 and Xp11.4) for sequences present in the YAC. The NFKB3 gene was assigned to chromosome 11q12 by PCR analysis of a panel of relevant hybrid cell lines. Thus, no linkage exists between NFKB3 and genes encoding other known members of the NF-[sub K]B family. 20 refs., 2 figs.

Deloukas, P.; Loon, A.P.G.M. van (F. Hoffmann-La Roche Ltd., Basel (Switzerland)); Dauwerse, J.G.; Ommen, G.J.B. van (Univ. of Leiden (Netherlands))

1994-02-01T23:59:59.000Z

146

Fucoidan prevents C{epsilon} germline transcription and NF{kappa}B p52 translocation for IgE production in B cells  

SciTech Connect

Fucoidan, a dietary fiber contained in seaweed, reduces the increase of antigen-specific IgE in mice exposed to ovalbumin. In this study, we investigated the effect of fucoidan on IgE production and intracellular events in B cells in vitro. Fucoidan inhibited the production of IgE and C{epsilon} germline transcription in murine B cells induced by IL-4 (100 ng/ml) and anti-CD40 antibodies (10 {mu}g/ml), whereas it stimulated cell proliferation. A significant effect of fucoidan on IgE production was observed when B cells were stimulated with a higher dose (5 {mu}g/ml) of anti-CD40 antibodies, but not when stimulated with lower doses (1.25, 2.5 {mu}g/ml), regardless of the IL-4 concentrations. Moreover, nuclear translocation of NF{kappa}B p52, but neither that of NF{kappa}B p65, nor the phosphorylation of JAK1 and STAT6 was reduced by fucoidan. These results suggest that fucoidan inhibited IgE production by preventing the NF{kappa}B p52-mediated pathways activated by CD40.

Oomizu, Souichi [Hiroshima Prefectural Institute of Industrial Science and Technology, Higashi-Hiroshima (Japan); Yanase, Yuhki [Hiroshima Prefectural Institute of Industrial Science and Technology, Higashi-Hiroshima (Japan); Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan); Suzuki, Hidenori [Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan); Kameyoshi, Yoshikazu [Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan); Hide, Michihiro [Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan)]. E-mail: mhide@hiroshima-u.ac.jp

2006-11-24T23:59:59.000Z

147

Research Article Curcumin Decreased Oxidative Stress, Inhibited NF-?B Activation, and Improved Liver Pathology in Ethanol-Induced Liver Injury in Rats  

E-Print Network (OSTI)

To study the mechanism of curcumin-attenuated inflammation and liver pathology in early stage of alcoholic liver disease, female Sprague-Dawley rats were divided into four groups and treated with ethanol or curcumin via an intragastric tube for 4 weeks. A control group treated with distilled water, and an ethanol group was treated with ethanol (7.5 g/kg bw). Treatment groups were fed with ethanol supplemented with curcumin (400 or 1 200 mg/kg bw). The liver histopathology in ethanol group revealed mild-tomoderate steatosis and mild necroinflammation. Hepatic MDA, hepatocyte apoptosis, and NF-?B activation increased significantly in ethanol-treated group when compared with control. Curcumin treatments resulted in improving of liver pathology, decreasing the elevation of hepatic MDA, and inhibition of NF-?B activation. The 400 mg/kg bw of curcumin treatment revealed only a trend of decreased hepatocyte apoptosis. However, the results of SOD activity, PPAR? protein expression showed no difference among the groups. In conclusion, curcumin improved liver histopathology in early stage of ethanol-induced liver injury by reduction of oxidative stress and inhibition of NF-?B activation. Copyright © 2009 Suchittra Samuhasaneeto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1.

Suchittra Samuhasaneeto; Duangporn Thong-ngam; Onanong Kulaputana; Doungsamon Suyasunanont; Naruemon Klaikeaw

2009-01-01T23:59:59.000Z

148

Investigation of surface inhomogeneity and estimation of the GOES skin temperature assimilation errors of the MM5 implied by the inhomogeneity over Houston metropolitan area  

E-Print Network (OSTI)

This study developed a parameterization method to investigate the impacts of inhomogeneous land surfaces on mesoscale model simulations using a high-resolution 1-d PBL model. Then, the 1-d PBL model was used to investigate the inhomogeneity-caused model errors in applying the GOES satellite skin temperature assimilation technique into the MM5 over the Houston metropolitan area (HOU). In order to investigate the surface inhomogeneity impacts on the surface fluxes and PBL variables over HOU, homo- and inhomogeneous 1-d PBL model simulations were performed over HOU and compared to each other. The 1-d PBL model was constructed so that the surface inhomogeneities were able to be represented within model grid elements using a methodology similar to Avissar and Pielke (1989). The surface inhomogeneities over HOU were defined using 30-m resolution land cover data produced by Global Environment Management (GEM), Inc. The inhomogeneity parameterization method developed in the 1-d model was applied to a standard MM5 simulation to test the applicability of the parameterization to 3-d mesoscale model simulations. From the 1-d simulations it was inferred that the surface inhomogeneities would enhance the sensible heat flux by about 36 % and reduce the latent heat flux by about 25 %, thereby inducing the warmer (0.7 %) and drier (-1.0 %) PBL and the colder and moister PBL top induced by greater turbulent diffusivities. The 3-d application of the inhomogeneity parameterization indicated consistent results with the 1-d in general, with additional effects of advection and differential local circulation. The original GOES simulation was warmer compared to observations over HOU than over surrounding areas. The satellite data assimilation itself would lead to a warm bias due to erroneous estimation of gridpoint-mean skin temperature by the satellite, but 1-d simulations indicate that the impact of this error should be much weaker than what was observed. It seems that, unless the already existing warm and dry bias of the MM5 is corrected, the inhomogeneity parameterization in the MM5 would adversely affect the MM5 performance. Therefore, consideration of the surface inhomogeneities in the urban area needs to be confined to the GOES skin temperature retrieval errors at the moment.

Han, Sang-Ok

2004-08-01T23:59:59.000Z

149

DETEW!INATION OF THE NEUTRON MAGNETIC FlONENT G.L. Greene and N.F. Ramsey  

NLE Websites -- All DOE Office Websites (Extended Search)

DETEW!INATION OF THE NEUTRON MAGNETIC FlONENT DETEW!INATION OF THE NEUTRON MAGNETIC FlONENT * G.L. Greene and N.F. Ramsey Harvard U n i v e r s i t y , Cambridge, N a s s a c h u s e t t s 02138 h W. Plampe i - I n s t i t u t Laue-Langevin, 38042 Grenoble, France' 9/ \ P J . M . P e n d l e b u r y and K. Smith " ' , \30ddb * A , 4 U n i v e r s i t y o f S u s s e x , Falmer, B r i g h t o n , B N I 9 Q H , U n i t e d Kingdom W . B . Dress and P.D. Miller -3 Oak Ridge N a t i o n a l L a b o r a t o r y , Oak Ridge, Tennessee 37838 P a u l P e r r i n C e n t r e d ' E t u d e s N u c l e a i r e s , 38042 C r e n o b l e , F r a n c e The n e u t r o n m a g n e t i c moment h a s been measured w i t h an improvement of a f a c t o r of 100 o v e r t h e p r e v i o u s b e s t measurement. s p e c t r o m e t e r o f t h e s e p a r a t e d o s c i l l a t o r y f i e l d t y p e c a p a b l e o f d e t e r m i n i n g a r e s o n a n c e s i g n a l f o r b o t h n e u t r o n s and p r o t o n s ( i n f l o w i n g H20), we f i n d u n / p p = 0.68497935(17)

150

Metropolitan Landfill Abatement Act (Minnesota)  

Energy.gov (U.S. Department of Energy (DOE))

A fee is imposed on operators of mixed municipal solid waste disposal facilities corresponding to the amount of waste taken in. Waste residue from recycling facilities or resource recovery...

151

nf]r Z  

E-Print Network (OSTI)

Dear Dr. Eggenberger: This letter provides a status ofthe Office of Environmental Management (EM) actions to complete Commitment 4.4 ofthe Department ofEnergy's (DOE) Implementation Plan for Recommendation 2002-3, Requirements for the Design, Implementation, and Maintenance ofAdministrative Controls. The commitment calls for the submission ofa report on training completed and copies ofchanges to relevant training plans regarding DOE-STD-II86-2004, Specific Administrative Controls. On November 4, 2004, the Secretary revised the due date to May 31, 2005, to allow additional time after the issuance ofthe standard in August 2004. We expect all EM actions under this commitment to be met within 90 days. EM sites and activities have completed the required initial training, except for one site. The contractor at the Richland Operations Office has initiated training and will complete the training in early June 2005. A summary ofthe training conducted at EM sites is enclosed. In addition, a compact disc containing the detailed training modules has been provided to your staff. EM sites are using a variety ofmeans to institutionalize DOE STD-1186-2004 into the various training programs as shown in the enclosure. These activities are in progress and are to be completed within 90 days. Ifyou have any further questions, please call me at (202) 586-7709 or

Jij-j L. L' i U H; I L. -' " ' i; The Honorable; A. J. Eggenberger

2005-01-01T23:59:59.000Z

152

Astroglial Inhibition of NF-kB Does Not Ameliorate Disease Onset and Progression in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)  

E-Print Network (OSTI)

Motor neuron death in amyotrophic lateral sclerosis (ALS) is considered a ‘‘non-cell autonomous’ ’ process, with astrocytes playing a critical role in disease progression. Glial cells are activated early in transgenic mice expressing mutant SOD1, suggesting that neuroinflammation has a relevant role in the cascade of events that trigger the death of motor neurons. An inflammatory cascade including COX2 expression, secretion of cytokines and release of NO from astrocytes may descend from activation of a NF-kB-mediated pathway observed in astrocytes from ALS patients and in experimental models. We have attempted rescue of transgenic mutant SOD1 mice through the inhibition of the NF-kB pathway selectively in astrocytes. Here we show that despite efficient inhibition of this major pathway, double transgenic mice expressing the mutant SOD1 G93A ubiquitously and the dominant negative form of IkBa (IkBaAA) in astrocytes under control of the GFAP promoter show no benefit in terms of onset and progression of disease. Our data indicate that motor neuron death in ALS cannot be prevented by inhibition of a single inflammatory pathway because alternative pathways are activated in the

Claudia Crosio; Cristiana Valle; Arianna Casciati; Ciro Iaccarino; Maria Teresa Carrì

2011-01-01T23:59:59.000Z

153

4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-{kappa}B and ERK/MAPK  

Science Conference Proceedings (OSTI)

Catechol estrogens, the hydroxylated metabolites of 17{beta}-estradiol (E{sub 2}), have been considered to be implicated in estrogen-induced carcinogenesis. 4-Hydroxyestradiol (4-OHE{sub 2}), an oxidized metabolite of E{sub 2} formed preferentially by cytochrome P450 1B1, reacts with DNA to form depurinating adducts thereby exerting genotoxicity and carcinogenicity. 4-OHE{sub 2} undergoes 2-electron oxidation to quinone via semiquinone, and during this process, reactive oxygen species (ROS) can be generated to cause DNA damage and cell death. In the present study, 4-OHE{sub 2} was found to elicit cytotoxicity in cultured human mammary epithelial (MCF-10A) cells, which was blocked by the antioxidant trolox. MCF-10A cells treated with 4-OHE{sub 2} exhibited increased intracellular ROS accumulation and 8-oxo-7,8-dihydroxy-2'-deoxyguanosine formation, and underwent apoptosis as determined by poly(ADP-ribose)polymerase cleavage and disruption of mitochondrial transmembrane potential. The redox-sensitive transcription factor nuclear factor {kappa}B (NF-{kappa}B) was transiently activated by 4-OHE{sub 2} treatment. Cotreatment of MCF-10A cells with the NF-{kappa}B inhibitor, L-1-tosylamido-2-phenylethyl chloromethyl ketone, exacerbated 4-OHE{sub 2}-induced cell death. 4-OHE{sub 2} also caused transient activation of extracellular signal-regulated protein kinases (ERK) involved in transmitting cell survival or death signals. A pharmacological inhibitor of ERK aggravated the 4-OHE{sub 2}-induced cytotoxicity, supporting the pivotal role of ERK in protecting against catechol estrogen-induced oxidative cell death.

Chen Zhihua [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Na, Hye-Kyung [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Hurh, Yeon-Jin [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Surh, Young-Joon [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of)]. E-mail: surh@plaza.snu.ac.kr

2005-10-01T23:59:59.000Z

154

ATF3 Plays a Key Role in Kdo 2-Lipid A-Induced TLR4- Dependent Gene Expression via NF-kB Activation  

E-Print Network (OSTI)

Background: Activating transcription factor 3 (ATF3) is a negative regulator of proinflammatory cytokine expression in macrophages, and ATF3 deficient mice are more susceptible to endotoxic shock. This study addresses the role of ATF3 in the Kdo 2-Lipid A-induced Toll-like receptor 4 (TLR4) signaling pathway in mouse embryonic fibroblasts (MEF). Kdo 2-Lipid A upregulates ATF3 expression in wild type MEF cells and induces both nuclear factor kappa B (NF-kB) and c-Jun N-terminal kinase (JNK) activation via the TLR4 signaling pathway, while neither of these pathways is activated in ATF3-/- MEF cells. Interestingly, in contrast to Kdo 2-Lipid A, the activation of both NF-kB and JNK by TNF-a was normal in ATF3-/- MEF cells. Methodology/Principal Findings: We found that several genes were dramatically upregulated in ATF3+/+ MEF cells in response to Kdo2-Lipid A treatment, while little difference was observed in the ATF3-/- MEF cells. However, we also found that the signal intensities of IkBf in ATF3-/- MEF cells were substantially higher than those in wild type MEF cells upon microarray analyses, and upregulated IkBf expression was detected in the cytosol fraction. Conclusions/Significance: Our findings indicate that ATF3 deficiency affects Kdo 2-Lipid A-induced TLR4 signaling pathways in MEF cells, that it may upregulate IkBf expression and that the high levels of IkBf expression in ATF3-/- cells disrupts Kdo2-Lipid A-mediated signaling pathways.

Eun-young Kim; Hye Young Shin; Joo-young Kim; Dong-gun Kim; Yong-min Choi; Dong-kwon Rhee; You-sun Kim; Sangdun Choi

2010-01-01T23:59:59.000Z

155

The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-{kappa}B and I{kappa}B-{gamma}: Implications for NF-{kappa}B-mediated signal transduction  

SciTech Connect

The NFKB1 gene encodes three proteins of the NF-{kappa}/Rel and I{kappa}B families: p105, p50, and (in mouse) I{kappa}B-{gamma}. We determined the complete genomic structure of human NFKB1. NFKB1 spans 156 kb and has 24 exons with introns varying between 40,000 and 323 bp in length. Although NFKB2, which encodes p100 and p52, also has 24 exons and has a comparable exon-intron structure, it is 20 times shorter than NFKB1. We propose that the long size of NFKB1 is important for transient activation of NF-{kappa}B complexes containing p50. I{kappa}B-{gamma} corresponds to the carboxyl-terminal half of p105. DNA sequence analysis showed that the 3{prime}-end of human intron 11 and the 5{prime}-end of exon 12 of NFKB1 are colinear with the 5{prime}-untranslated region of mouse I{kappa}B-{gamma} cDNA. I{kappa}B-{gamma} is thus likely to be generated by transcription starting within intron 11 and not by alternative splicing of the mouse mRNA encoding p105 and p50. 71 refs., 5 figs., 1 tab.

Heron, E.; Deloukas, P.; van Loon, A.P.G.M. [F. Hoffmann-La Roche Limited, Basel (Switzerland)] [F. Hoffmann-La Roche Limited, Basel (Switzerland)

1995-12-10T23:59:59.000Z

156

Numerical investigation of the pulsed NF3 + H2 chemical laser using a model which includes rotational relaxation and semi-classical laser equations  

DOE Green Energy (OSTI)

Waveforms and population distributions have been calculated by a numerical model and compared with experiment for an electric-discharge-initiated, pulsed NF$sub 3$ + H$sub 2$ chemical laser. The model treats each vibrational- rotational state separately, allowing rotational relaxation between adjacent states as well as vibrational relaxation and lasing according to P-branch selection rules. Calculated waveforms agree with experiment and show several features not seen when rotational equilibrium is assumed: simultaneous lasing on many transitions, cascade behavior, spikes due to laser relaxation oscillations, non-Boltzmann rotational distributions, and ''hole burning'' in the population distributions. The calculations give insight into the physical phenomena governing the shape and duration of the waveforms. The effect of varying certain parameters, relaxation rates, temperature, pressure, and diluents, is studied. Best fit to experimental waveforms is obtained when the rotational relaxation rate and collisional line broadening rate are approximately equal at about 10 times the hard sphere collision rate. The IXION computer code, developed for these calculations, is described in detail. In addition, an analytic model is presented which accounts for major features of the total (all transitions) output waveform of the laser assuming rotational equilibrium, a steady state laser model, and constant temperature. A second computer code, MINOTAR, was developed as a general purpose chemical kinetics code. It verifies the analytic model and extends the results to adiabatic reactions where the temperature varies, and can yield waveforms using the assumptions of rotational equilibrium and a steady state laser. The MINOTAR code, being general, can also be used for chemical kinetics problems such as air pollution and combustion. (auth)

Creighton, J.R.

1975-09-01T23:59:59.000Z

157

Numerical investigation of the pulsed NF3 + H2 chemical laser using a model which includes rotational relaxation and semi-classical laser equations  

SciTech Connect

Waveforms and population distributions have been calculated by a numerical model and compared with experiment for an electric-discharge-initiated, pulsed NF$sub 3$ + H$sub 2$ chemical laser. The model treats each vibrational- rotational state separately, allowing rotational relaxation between adjacent states as well as vibrational relaxation and lasing according to P-branch selection rules. Calculated waveforms agree with experiment and show several features not seen when rotational equilibrium is assumed: simultaneous lasing on many transitions, cascade behavior, spikes due to laser relaxation oscillations, non-Boltzmann rotational distributions, and ''hole burning'' in the population distributions. The calculations give insight into the physical phenomena governing the shape and duration of the waveforms. The effect of varying certain parameters, relaxation rates, temperature, pressure, and diluents, is studied. Best fit to experimental waveforms is obtained when the rotational relaxation rate and collisional line broadening rate are approximately equal at about 10 times the hard sphere collision rate. The IXION computer code, developed for these calculations, is described in detail. In addition, an analytic model is presented which accounts for major features of the total (all transitions) output waveform of the laser assuming rotational equilibrium, a steady state laser model, and constant temperature. A second computer code, MINOTAR, was developed as a general purpose chemical kinetics code. It verifies the analytic model and extends the results to adiabatic reactions where the temperature varies, and can yield waveforms using the assumptions of rotational equilibrium and a steady state laser. The MINOTAR code, being general, can also be used for chemical kinetics problems such as air pollution and combustion. (auth)

Creighton, J.R.

1975-09-01T23:59:59.000Z

158

The Vertical Turn: Topographies of Metropolitan Modernism  

E-Print Network (OSTI)

Its Discontents: Essays on the New Mobility of People and214 Although this new vertical mobility was largely embracedhave produced new possibilities for mobility, simultaneity,

Haacke, Paul

2011-01-01T23:59:59.000Z

159

The Vertical Turn: Topographies of Metropolitan Modernism  

E-Print Network (OSTI)

s Catch-22; Billy Pilgrim, who becomes fantastically “Heller’s Catch-22; Billy Pilgrim, who becomes “unstuck indead people. Billy Pilgrim explains: “When a Tralfamadorian

Haacke, Paul

2011-01-01T23:59:59.000Z

160

Manchester Metropolitan University Organisation Development, Training & Diversity  

E-Print Network (OSTI)

and diversity by its continuing progress, we appreciate that there is still more work to be done. The University and to meet the statutory requirements for each protected characteristic. It is a live document which and communicate overarching equality objectives. DS DES EF 1. Draft new equality objectives in line

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161

METROPOLITAN TRANSPORTATION SUPPORT INITIATIVE (METSI) QUARTERLY REPORT  

E-Print Network (OSTI)

, to be updated on a regular basis, will constitute the baseline for subsequent NEPA analyses. 2. Progress during of proposed fishery regulations and similar activities on "fishing communities." NEPA analysis contained/3 of Hawaii's commercial fish (measured in pounds; 2002 data). Previous socio- anthropological studies have

Illinois at Chicago, University of

162

METROPOLITAN TRANSPORTATION SUPPORT INITIATIVE (METSI) QUARTERLY REPORT  

E-Print Network (OSTI)

on Historic Preservation ADS Activity Data Sheet system AGS Alternating Gradient Synchrotron AIRFA American............................................................................................. 49 7.0 Scheduled Updates National Environmental Policy Act (NEPA) and Cultural Resource Reviews Attachment 28: RC-SOP-501 Project

Illinois at Chicago, University of

163

Ryan Groom & Simon Wilson Manchester Metropolitan University  

E-Print Network (OSTI)

#12;Building a Department Scene 2 #12;McKinsey - 7S Model Skills Strategy System Style Staff Shared Values Structure Figure 1. McKinsey 7S Model (Waterman, Peters, & Philips, 1980). #12;Thinking Tools

164

The Vertical Turn: Topographies of Metropolitan Modernism  

E-Print Network (OSTI)

pastoral city, with the tall tower standing as a guidingreach a church with a tall tower, which she climbs up. Then,tall sequoia trees outside the city, and of course the church tower

Haacke, Paul

2011-01-01T23:59:59.000Z

165

The Vertical Turn: Topographies of Metropolitan Modernism  

E-Print Network (OSTI)

1948: “In an atomic war, congested cities would become deathcrashes down on the city like an atomic bomb. The heat is

Haacke, Paul

2011-01-01T23:59:59.000Z

166

The Vertical Turn: Topographies of Metropolitan Modernism  

E-Print Network (OSTI)

superpower of the atomic age, these vertical structures andPan-Romanticism in the Atomic Age” before turning to myand the emergence of the atomic age. 228 Dos Passos, John.

Haacke, Paul

2011-01-01T23:59:59.000Z

167

High-loop perturbative renormalization constants for Lattice QCD (II): three-loop quark currents for tree-level Symanzik improved gauge action and n_f=2 Wilson fermions  

E-Print Network (OSTI)

Numerical Stochastic Perturbation Theory was able to get three- (and even four-) loop results for finite Lattice QCD renormalization constants. More recently, a conceptual and technical framework has been devised to tame finite size effects, which had been reported to be significant for (logarithmically) divergent renormalization constants. In this work we present three-loop results for fermion bilinears in the Lattice QCD regularization defined by tree-level Symanzik improved gauge action and n_f=2 Wilson fermions. We discuss both finite and divergent renormalization constants in the RI'-MOM scheme. Since renormalization conditions are defined in the chiral limit, our results also apply to Twisted Mass QCD, for which non-perturbative computations of the same quantities are available. We emphasize the importance of carefully accounting for both finite lattice space and finite volume effects. In our opinion the latter have in general not attracted the attention they would deserve.

Brambilla, Michele

2013-01-01T23:59:59.000Z

168

The human transcription factor CP2 (TFCP2), a component of the human {gamma}-globin stage selector protein, maps to chromosome region 12q13 and is within 250 kb of the NF-E2 gene  

SciTech Connect

The transcription factor CP2{sup 2} has been shown to bind to several cellular and viral promoters as a homodimer. More recently, we have demonstrated that CP2 can form a heterodimer with a 45-kDa partner protein to form the stage selector protein complex (SSP). This complex binds to a proximal {gamma}-globin promoter regulatory element, the stage selector element (SSE), which appears to be involved in the competitive silencing of the {beta}-gene in the fetal stage of erythropoiesis. Similar SSP-like binding sites have been identified in the {beta}-globin promoter and regulatory elements of the {beta}-globin locus control region (LCR). The importance of the SSP complex is further emphasized by the fact that the chicken stage selector protein, NF-E4, which has been implicated in the competitive silencing of the chicken {epsilon}-globin gene, is the avian homologue of CP2. The purpose of this study is to map human CP2 genomically and define its relationship to previously identified loci. 9 refs., 1 fig.

Cunningham, J.M.; Tran, N.; Valentine, M. [St. Jude Children`s Research Hospital, Memphis, TN (United States)] [and others

1995-11-20T23:59:59.000Z

169

Mechanical Properties of Advanced NF616 Steel  

Science Conference Proceedings (OSTI)

... of TIG Welded and Laser-surface Melted SUS 304 for Nuclear Power Plants ... Statistics of Grain Boundary Crystallography in Surrogates for Oxide Nuclear ...

170

You give me fever : practical protection for metropolitan neuroses  

E-Print Network (OSTI)

The emergence of Swine Flu in the past six months has once again heightened the world's fears of a coming flu pandemic. Although H1N1 is only slightly more pathogenic than the common seasonal flu, which kills approximately ...

Case, Keith William

2010-01-01T23:59:59.000Z

171

CSOnet: A Metropolitan Scale Wireless Sensor-Actuator Network  

E-Print Network (OSTI)

increasing the capacity of the wastewater treatment plant (WWTP) or building large off-line storage sensed data to power actuators which can then effect the sensed environment. The resulting changes treatment plants, automatic chemical processes, energy efficient HVAC systems and power grid control

Lemmon, Michael

172

New Ruralism: Agriculture at the Metropolitan Edge [Dispatch  

E-Print Network (OSTI)

a pro- motional “white paper” outlining the activitiesvision. According to the white paper: “Larger home sites,

Moffat, David

2006-01-01T23:59:59.000Z

173

Manchester Metropolitan University December 2010 Corporate Planning Statement  

E-Print Network (OSTI)

at the Digital Ecosystems and Business Intelligence Institute, Curtin University of Technology, Australia. He has Statistics 2010 supports that 63% electricity in the United States comes from fossil fuel combustion, while electricity sup- plies. In the United States, the meaning of SG is much broader, referring to a means

174

Simulation and Visualization of Airside Operations at Detroit Metropolitan Airport  

E-Print Network (OSTI)

In recent years, airline flight delays have been among the most troublesome problems in the national transportation system. Although bad weather has historically been the main cause of delays, a growing reason has been the inability of the nation’s air transport system to efficiently absorb all of the aircraft trying to use limited airspace or trying to take off or land at busy airports. Simulation modeling and visualization can be of substantial help in the efficient design of airport operations, which in turn can mitigate some of the abovementioned capacity problems. This study presents the simulation model and 3D animation of the airside airport operations at Detroit Metro Airport, Romulus, Michigan. The simulation model is developed in STROBOSCOPE (Martinez 1996) and the 3D animation is created using

Copyright Hiam; M. Khoury; Vineet R. Kamat; Vineet R. Kamat; Photios G. Ioannou; Photios G. Ioannou; Hiam M. Khoury; Hiam M. Khoury

2005-01-01T23:59:59.000Z

175

Transit planning in metropolitan Seattle: a historical perspective. Final report  

SciTech Connect

The document provides a historical overview of trends in transit planning to casing on the experiences of Seattle, Washington as a case study. It focuses on the period from the 1940's to the present, detailing major transit initiatives and the planning process which led to them. The document includes a detailed chronological review of events affecting transportation planning, both in Seattle and nationwide.

Malm, R.

1986-04-01T23:59:59.000Z

176

After Exodus : re-occupation of the metropolitan wall  

E-Print Network (OSTI)

The title "Exodus alludes to a restricted exclave encircled by a forbidding wall -- effect, a prison on the scale of a metropolis, and one in which people sought refuge voluntarily. Over the past forty years, similar walls ...

Allison, Jordan Lloyd Norman

2012-01-01T23:59:59.000Z

177

EIA initiates daily gasoline availability survey for metropolitan ...  

U.S. Energy Information Administration (EIA)

Biofuels: Ethanol & Biodiesel ... As a result of the subsequent disruptions to the supply chain for gasoline, EIA implemented an emergency survey starting on Friday ...

178

Open space system study for the Dacca metropolitan area  

E-Print Network (OSTI)

Open space facilities proposed in the Master Plan for Dacca, 1960, based on zoning by land subdivision, although inadequate in terms of population needs, were never realized -- partly due to their turnover to other land hungry urban developments. A comprehensive step to solve the problem of open space needs for present and future Decca was sought through an ecological approach. The search was for land of intrinsic open space value to be developed with compatible land uses to arrive at a system of multiple values. The map of Dacca published by the geological survey of Pakistan and supporting reference material was analysed for an understanding of the city's various features -- water and wetland, settlement pattern, climate, community, transportation and vegetation. The analytical facts were synthesized to socio-cultural image study, road system study, end finally, open space system study. These studies are based on existing and future physical, socio-cultural growth patterns. It was found out that the rivers, canals, wetlands encircling Dacca could "be the median of an open space system developed with the compatible land use of flood and erosion control, drainage, water supply, agriculture, water transportation and recreation. The system incorporates existing parks, open spaces, and historic value nodes, proposes pedestrian shopping malls, pedestrian, levels in highways, and, reserves spaces for institution and housing expansion.

Rab, Wajeda Jafar

1970-01-01T23:59:59.000Z

179

Atmospheric Chemistry and Physics  

E-Print Network (OSTI)

Abstract. A 3-D chemistry-transport model has been applied to the Mexico City metropolitan area to investigate the origin of elevated levels of non-fossil (NF) carbonaceous aerosols observed in this highly urbanized region. High time resolution measurements of the fine aerosol concentration and composition, and 12 or 24 h integrated 14 C measurements of aerosol modern carbon have been performed in and near Mexico City during the March 2006 MILAGRO field experiment. The non-fossil carbon fraction (fNF), which is lower than the measured modern fraction (fM) due to the elevated 14 C in the atmosphere caused by nuclear bomb testing, is estimated from the measured fM and the source-dependent information on modern carbon enrichment. The fNF contained in PM1 total carbon analyzed by a US team (f TC

unknown authors

2010-01-01T23:59:59.000Z

180

Beam Loading Computation for the IDS-NF FFAG  

SciTech Connect

I accumulate the information we have for the current baseline design for a neutrino factory to determine the maximum current we can expect at the final FFAG accelerating stage. I then determine the energy extracted from the RF cavities in the FFAG, and from that determine how much time there must be between bunch trains to restore the energy to the RF cavities so that each bunch train has the same energy at the storage ring. I also estimate the amount of energy variation from the head to the tail of the bunch train.

Berg, J.S.

2011-10-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

CMRR-NF Supplemental EIS Scoping Comments | National Nuclear...  

National Nuclear Security Administration (NNSA)

Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management...

182

Solar Spectral Irradiance under Clear Skies around a Major Metropolitan Area  

Science Conference Proceedings (OSTI)

This paper investigates the influence of gaseous pollutants and aerosol on the spectral composition of various segments of the solar spectrum in cloudless conditions. This investigation is done by using data of the spectral energy distribution of ...

C. P. Jacovides; Michael D. Steven; D. N. Asimakopoulos

2000-06-01T23:59:59.000Z

183

Human Exposure to Toxic Materials The New York-New Jersey Metropolitan Region  

E-Print Network (OSTI)

, such as SO, and NO, and other petroleum combustion products, is pro- duced by the operation of internal sources (Table 1) (1).Airborne emissions are directly related to problems of contaminated sediments. First. The fine particles are derived chiefly from fossil fuel combustion sources and their size range contrib

Brookhaven National Laboratory

184

METROPOLITAN TRANSPORTATION SUPPORT INITIATIVE For the Illinois Department of Transportation (IDOT)  

E-Print Network (OSTI)

and national private providers in order to foster public-private partnerships. Below is a description

Illinois at Chicago, University of

185

METROPOLITAN TRANSPORTATION SUPPORT INITIATIVE For the Illinois Department of Transportation (IDOT)  

E-Print Network (OSTI)

for July 22 in Oak Park. -The paper "Chicago's CREATE Rail Program: A Successful Public-Private Partnership

Illinois at Chicago, University of

186

Metropolitan New York in the greenhouse: Air quality and health effects  

SciTech Connect

A variety of potential effects on human health resulting from climate change have been identified in several assessments. According to an international panel{sup 1} they include direct effects of extreme temperatures on cardiovascular deaths, secondary effects due to vector-borne diseases or crop yields, and tertiary effects such as those that might arise from conflicts over freshwater supplies. To this fist we add the secondary effects of increased air pollution, which may result either directly from climate change or indirectly from increased air conditioning loads and the corresponding pollutant emissions from electric utilities. Higher ozone concentrations have been linked to increased ambient temperatures by both theory and observations of monitoring data. A similar association with particulate matter has been limited to observations, thus far. The pollution-heat linkage has been recognized before` but health effects have not been evaluated in terms of predictions of the joint effects of both agents. This paper has been prepared in two sections. First, we discuss the ozone situation with special reference to the Northeast Corridor and New York. In the second section, we present estimates of the health effects of climate change on New York and discuss some mitigation options.

Kleinman, L.I.; Lipfert, F.

1996-01-01T23:59:59.000Z

187

Executive Summary The Morgantown metropolitan statistical area (MSA) accelerated during 2010, after posting slow  

E-Print Network (OSTI)

facility, and a National Energy Technology Lab site, among others. Local government jobs, primarily.D. Associate Director, BBER and Associate Professor of Economics Jordan Hantz, Undergraduate Research Assistant.bber.wvu.edu This conference is made possible by the following underwriters: Chesapeake Energy Corporation Morgantown Area

Mohaghegh, Shahab

188

Executive Summary The Morgantown metropolitan statistical area (MSA) continued to expand in 2011, adding jobs  

E-Print Network (OSTI)

in natural resources and mining during the forecast, which reflects the startup of a new CONSOL Energy coal Assistant Jordan Hantz, Undergraduate Research Assistant This document is published by the Bureau underwriters: Chesapeake Energy Corporation Morgantown Area Economic Partnership The Dominion Post The State

Mohaghegh, Shahab

189

MEMORANDUM OF UNDERSTANDING BETWEEN THE METROPOLITAN COUNCIL, REGENTS OF THE UNIVERSITY OF  

E-Print Network (OSTI)

the development of a Central Corridor Light Rail Transit ("CCLRT") line; 2. The Parties agree that a portion-grade Transit/Pedestrian Mall on Washington Avenue with no vehicular traffic except emergency vehicles, light, the extension of East River Road to Main Street, has been identified by the Parties as a traffic mitigation

Amin, S. Massoud

190

State and Metropolitan Area Impacts of the Offshore Outsourcing of Business Services and IT  

E-Print Network (OSTI)

US Services Jobs to Go Offshore." Forrester Research, IT37. Garry, G.C. 1999. "Offshore programmers: The wave of theInsight. The Impact of Offshore IT Software and Services

Kroll, Cynthia A.

2005-01-01T23:59:59.000Z

191

Real-time air quality monitoring through mobile sensing in metropolitan areas  

Science Conference Proceedings (OSTI)

Traditionally, pollution measurements are performed using expensive equipment at fixed locations or dedicated mobile equipment laboratories. This is a coarse-grained and expensive approach where the pollution measurements are few and far in-between. ... Keywords: air quality, mobile sensing, participatory sensing, pollution, social networks, urban sensing

Srinivas Devarakonda, Parveen Sevusu, Hongzhang Liu, Ruilin Liu, Liviu Iftode, Badri Nath

2013-08-01T23:59:59.000Z

192

Emission Testing of Washington Metropolitan Area Transit Authority (WMATA) Natural Gas and Diesel Transit Buses  

DOE Green Energy (OSTI)

An evaluation of emissions of natural gas and diesel buses operated by the Washington Metro Area Transit Authority.

Melendez, M.; Taylor, J.; Wayne, W. S.; Smith, D.; Zuboy, J.

2005-12-01T23:59:59.000Z

193

Car Based Transport and Transit Oriented Metropolitan —— Chinese Urban Motorization Pathways  

E-Print Network (OSTI)

reprocessing of used motor oil are a serious environmentalcan be traced to motor fuels and the oils and salts that

Ximing, Lu

2008-01-01T23:59:59.000Z

194

Planners and the Pork Barrel: Metropolitan Engagement in and Resistance to Congressional Transportation Earmarking  

E-Print Network (OSTI)

s why it’s not on the STIP,’” the state capital program.projects already in the TIP or STIP are twofold. First, fromstate capital program or STIP: .[I]t took money that had

Sciara, Gian-Claudia

2009-01-01T23:59:59.000Z

195

An Analysis of the Impacts of British Transport Reforms on Transit Integration in the Metropolitan Areas  

E-Print Network (OSTI)

to Decide (Transport White Paper), Luxembourg: Office forSADOT), 1996. Transport White Paper, Pretoria. ________,Everyone (Transport White Paper), London: HMSO. ________,

Rivasplata, Charles Richard

2006-01-01T23:59:59.000Z

196

Tornadoes in the New York Metropolitan Region: Climatology and Multiscale Analysis of Two Events  

Science Conference Proceedings (OSTI)

This paper describes the climatology of tornadoes around New York City (NYC) and Long Island (LI), New York, and the structural evolution of two tornadic events that affected NYC on 8 August 2007 and 16 September 2010. Nearly half (18 of 34 events ...

Brian A. Colle; Kelly A. Lombardo; Jeffrey S. Tongue; William Goodman; Nelson Vaz

2012-12-01T23:59:59.000Z

197

A policy story of continuity and change : reflections on the Obama Administration's Metropolitan Agenda  

E-Print Network (OSTI)

President Obama was sworn into office on January 20, 2009 and within the first month of his presidency, against a backdrop of staggering concerns about financial reform, energy efficiency, and the need to allocate $787 ...

Ullah, Athena Jade

2011-01-01T23:59:59.000Z

198

Sustainable metropolitan mobility and public-private partnerships : a highway to institutional reform?  

E-Print Network (OSTI)

The "sustainability" literature generally acknowledges a critical role for transportation infrastructure planning, finance, investment, design, construction, operation, and management for addressing the long-term viability ...

Grillo, Christopher C. (Christopher Charles)

2011-01-01T23:59:59.000Z

199

An Analysis Of Teacher Distribution Across Districts And Schools In The Detroit Metropolitan Area.  

E-Print Network (OSTI)

??The demand that today's schools shall produce better educational outcomes of their pupils is stronger than ever before, especially in front of the background of… (more)

Krispien, Christina Susanne

2010-01-01T23:59:59.000Z

200

Executive Summary The Morgantown metropolitan statistical area (MSA) outperformed both the state and the nation  

E-Print Network (OSTI)

Unemployment Rate 9.3 9.9 9.3 8.3 7.5 7.0 Federal Funds Rate 0.16 0.24 1.70 3.34 3.55 4.59 30-Year Fixed through 2014. Monetary policy is expected to remain accommodative through 2010. The federal funds rate infrastructure. Morgantown MSA Outlook FORECAST: 2010-2014 March 2010 BUREAU OF BUSINESS AND ECONOMIC RESEARCH

Mohaghegh, Shahab

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Executive Summary The Morgantown metropolitan statistical area (MSA) continued to expand in 2011, adding jobs  

E-Print Network (OSTI)

to remain low until 2014. As Figure 4 shows, the federal funds rate is expected to stay in the 0.10 range until 2014, when it jumps to 1.23 percent. The federal funds rate is then expected to rise to 4 6 8 10 12 14 16 FederalFundsRate(%) Forecast Figure 4 The Federal Budget Deficit Declines While

Mohaghegh, Shahab

202

A Metropolitan-Scale Testbed for Heterogeneous Wireless Sensor Networks to  

E-Print Network (OSTI)

by instrumenting the award-winning solar house developed by the architecture department of the Technische testbed has four major application domains where it is being applied: TU Darmstadt's award winning solar house, where temperature and CO2 levels are monitored; an 80 year old building in which a WSN

Darmstadt, Technische Universität

203

After the Fall: An Ex Post Characterization of Housing Price Declines Across Metropolitan Areas  

E-Print Network (OSTI)

Model: How Much Do House Prices Matter?" , Real EstateThe Subprime Crisis and House Price Appreciation", NationalT. 2005, "Assessing High House Prices: Bubbles, Fundamentals

Carson, Richard T; Dastrup, Samuel R.

2009-01-01T23:59:59.000Z

204

East Coast Cool-Weather Storms in the New York Metropolitan Region  

Science Conference Proceedings (OSTI)

New York coastal regions are frequently exposed to winter extratropical storm systems that exhibit a wide range of local impacts. Studies of these systems either have used localized water-level or beach erosion data to identify and characterize ...

H. Salmun; A. Molod; F. S. Buonaiuto; K. Wisniewska; K. C. Clarke

2009-11-01T23:59:59.000Z

205

Planners and the Pork Barrel: Metropolitan Engagement in and Resistance to Congressional Transportation Earmarking  

E-Print Network (OSTI)

such as a bus or rail-car purchase; or research or planninga bus or rail-car purchase; or specific research or planningRail Transit in Los Angeles," Journal of Architectural and Planning Research

Sciara, Gian-Claudia

2009-01-01T23:59:59.000Z

206

A plan for Metropolitan State Hospital : imagery as a therapy for an institution  

E-Print Network (OSTI)

This thesis is both text and illustration to describe the process of transforming a state mental institution from an outdated, outmoded, conventional hospital into a living community. The goal of the project is to develop ...

McMurrin, Sterling James

1988-01-01T23:59:59.000Z

207

Planners and the Pork Barrel: Metropolitan Engagement in and Resistance to Congressional Transportation Earmarking  

E-Print Network (OSTI)

and MPOs to plan for future transportation improvementsneeds and estimated future transportation funds, they seedesirable transportation investments for the future. The MPO

Sciara, Gian-Claudia

2009-01-01T23:59:59.000Z

208

Regional Resilience in the Face of Foreclosures: Evidence from Six Metropolitan Areas  

E-Print Network (OSTI)

Figure 2. Pre-foreclosures by zip code in the St. LouisFigure 3. Pre-foreclosures by zip code in the Inland Empire,Pre-foreclosure notices by zip code, San Francisco Bay Area,

Todd Swanstrom; Karen Chapple; Dan Immergluck

2009-01-01T23:59:59.000Z

209

The influence of peer, community and religion on adolescent substance use in the Cape Metropolitan area.  

E-Print Network (OSTI)

??The aim of this study was to investigate the impact of peer, community and religious influences on alcohol and tobacco use among high school adolescents… (more)

Gana, Thandeka Christine

2004-01-01T23:59:59.000Z

210

Manchester Metropolitan University, the owners of the former Alsager Campus, will soon make an  

E-Print Network (OSTI)

· legionellosis · leptospirosis · lyme disease · q fever · rabies · streptococcus suis · tetanus · tuberculosis

211

Flash Flood Forecasting for Small Urban Watersheds in the Baltimore Metropolitan Region  

Science Conference Proceedings (OSTI)

The utility of distributed hydrologic models in combination with high-resolution Weather Surveillance Radar-1988 Doppler (WSR-88D) rainfall estimates for flash flood forecasting in urban drainage basins is examined through model simulations of 10 ...

Julie Rose N. Javier; James A. Smith; Katherine L. Meierdiercks; Mary Lynn Baeck; Andrew J. Miller

2007-12-01T23:59:59.000Z

212

Technology and policy options for reducing industrial air pollutants in the Mexico City Metropolitan Area  

E-Print Network (OSTI)

Technology plays an important role in dealing with air pollution and other environmental problems faced by developing and developed societies. This research examines if technological solutions alone, such as end-of-pipe ...

Vijay, Samudra, 1968-

2005-01-01T23:59:59.000Z

213

Green optical network design : power optimization of wide area and metropolitan area networks  

E-Print Network (OSTI)

Advancements in technology are fueling huge growth in network traffic capacity. Demand for low cost, reliable, and high bitrate transmissions grows 40-110% internationally every year. To date, most research has focused on ...

Lin, Katherine Xiaoyan

2011-01-01T23:59:59.000Z

214

Technological analysis of options for generating electricity with solid waste fuel in the Bangkok metropolitan area  

SciTech Connect

A discussion of relatively current techniques for converting mixed municipal waste into electricity is presented. A brief review of the comparative capabilities of the relevant energy recovery systems is documented in this section. The discussion is focused on the principal system and technological strategies that would be best suited for the municipal solid waste recovery project in Thailand. Emphasis in the review was placed on mixed waste processing in a mass burning waterwalled system.

1985-09-01T23:59:59.000Z

215

Planners and the Pork Barrel: Metropolitan Engagement in and Resistance to Congressional Transportation Earmarking  

E-Print Network (OSTI)

organizations and state agencies to bolster their processesto be addressed by state agencies. Regionalism, defined herematters to federal and state agencies as well; when Congress

Sciara, Gian-Claudia

2009-01-01T23:59:59.000Z

216

Suppression and Dissipation of Weak Tornadoes in Metropolitan Areas: A Case Study of Greater London  

Science Conference Proceedings (OSTI)

Examination of the distribution of property-damaging tornadoes which have occurred in and around Greater London since 1830 reveals that the inner parts of the metropolis have experienced relatively few tornadoes during the past 150 years compared ...

Derek M. Elsom; G. Terence Meaden

1982-07-01T23:59:59.000Z

217

The Frequency of High-Impact Convective Weather Events in the Twin Cities Metropolitan Area, Minnesota  

Science Conference Proceedings (OSTI)

Thunderstorms frequently produce brief flooding or minor damage, though far fewer lead to major flooding and widespread or significant damage. Outbreaks of such storms exact large tolls on their victims and can compromise, or completely overwhelm,...

Kenneth A. Blumenfeld

2010-04-01T23:59:59.000Z

218

AMBIENT HYDROCARBONS IN THE HOUSTON METROPOLITAN AREA DURING TEXAQS 2000: AN IDENTIFICATION OF UNUSUAL FEATURES.  

SciTech Connect

Houston's ozone problem has been linked to the occurrence of very high light olefin concentrations. We have analyzed the DOE G-1 aircraft hydrocarbon data set to provide additional information on the geographic distribution and prevalence of air samples with high olefin concentration as well as an identification of other compounds which contribute to the high hydrocarbon reactivity in Houston. In order to identify high concentrations we need a definition of normal. For that purpose we use aircraft samples collected during a 1999 aircraft based field campaign in Philadelphia relying on the circumstance that the frequency distributions of NO{sub x} and C{sub 2}H{sub 2} in Philadelphia are nearly the same as in Houston. Comparison is made also with hydrocarbons collected in Phoenix which exhibit nearly the same NO{sub x} and C{sub 2}H{sub 2} frequency distribution as the other 2 cities, but in spite of that similarity have a much lower hydrocarbon reactivity. As in other studies we find that there is a subset of Houston hydrocarbon samples with very high OH-reactivity due to elevated concentrations of ethylene, propylene and less often butenes, including 1,3 butadiene. Although these samples stand out as being qualitatively different we present evidence that ethylene and propylene are significantly elevated in at least half of the Houston samples, covering a wide geographic area apart from the Ship Channel region. Frequency distributions for these compounds are log normal suggesting that Houston's atmosphere is a single entity rather than separate industrial and urban areas. The comparison between Houston and Philadelphia also identifies C{sub 2}-C{sub 5} alkanes, n-hexane, and benzene as having elevated concentrations. Emission reductions of these less reactive compounds sufficient to yield the concentrations observed in Philadelphia would have a minor effect on the most reactive samples, but about a 20% effect on samples with more typical (median) reactivity.

KLEINMAN, L.I.; DAUM P.H.

2004-11-01T23:59:59.000Z

219

Formation of semivolatile inorganic aerosols in the Mexico City Metropolitan Area during the MILAGRO campaign  

E-Print Network (OSTI)

One of the most challenging tasks for chemical transport models (CTMs) is the prediction of the formation and partitioning of the major semi-volatile inorganic aerosol components (nitrate, chloride, ammonium) between the ...

Karydis, V. A.

220

Planners and the Pork Barrel: Metropolitan Engagement in and Resistance to Congressional Transportation Earmarking  

E-Print Network (OSTI)

January 2, 2008). Office of Inspector General, Review ofof Transportation, Office of Inspector General, 2007), 9.of Transportation, Office of Inspector General, 2007. These

Sciara, Gian-Claudia

2009-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Analysis of positional aspects in the variation of real estate values in an italian southern metropolitan area  

Science Conference Proceedings (OSTI)

The paper show the use of a fuzzy weighting system to identify the correspondence of real estate value with main socio-physical characters of the urban tissue. The descriptor of the relationship with the real estate value is represented by a set of indicators ... Keywords: SatScan, estate value, fuzzy logic, semantic distance

Silvestro Montrone; Paola Perchinunno; Carmelo Maria Torre

2010-03-01T23:59:59.000Z

222

Development and application of GIS-based analysis/synthesis modeling techniques for urban planning of Istanbul Metropolitan Area  

Science Conference Proceedings (OSTI)

Istanbul is the largest city in Turkey with an area of around 5750km^2 and population of around 10.58M (2000). The population is increasing because of mass immigration. Planned and unplanned housing are increasing while green areas are decreasing in ... Keywords: Geographic information systems, Istanbul, Modeling, Spatial evaluation, Sustainability

Ibrahim Baz; Abdurrahman Geymen; Semih Nogay Er

2009-02-01T23:59:59.000Z

223

From Cars to Casinos: Global Pasts and Local Futures in the Detroit-Windsor Transnational Metropolitan Area [book chapter  

E-Print Network (OSTI)

Over the past twenty years the topics of globalization and the global city have come to dominate the intellectual dialogue on international planning and development. Related issues like poverty, neocolonialism, sustainability, ...

Ryan, Brent D.

224

MAKING DO: How Working Families in Seven U.S. Metropolitan Areas Trade Off Housing Costs and Commuting Times  

E-Print Network (OSTI)

worker households trip-maker DRIVE ALONE/Disabled trip-maker CARPOOL/Disabled trip-makerPUBLIC TRANSIT/Disabled trip-maker BIKE-PED/Disabled trip-

2006-01-01T23:59:59.000Z

225

DESIGN AND DEPLOYMENT OF A MOBILE SENSOR NETWORK FOR THE SURVEILLANCE OF NUCLEAR MATERIALS IN METROPOLITAN AREAS  

E-Print Network (OSTI)

surveillance of nuclear materials in major cities. Specifically, the network consists of a large numberDESIGN AND DEPLOYMENT OF A MOBILE SENSOR NETWORK FOR THE SURVEILLANCE OF NUCLEAR MATERIALS, Rutgers University Piscataway, NJ 08854 Piscataway, NJ 08854 Key Words: Nuclear Detection and Surveillance

226

The Resonance of the Surface Waves. The H/V Ratio in the Metropolitan Area of Bucharest  

SciTech Connect

The purpose of this work is to evaluate the natural period of oscillation T{sub 0} for soils in Bucharest city area. We will start by examine the elastic waves excited at the surface of an isotropic body by an oscillatory, localized force (Rayleigh waves). We define the 'H/V'-ratio as the ratio of the intensity of the in-plane waves (horizontal waves) to the intensity of the perpendicular-to-the-plane waves (vertical waves). It is shown that this ratio exhibits a resonance at a frequency which is close to the frequency of the transverse waves. It may serve to determine Poison's ratio of the body. We consider the ratio H/V of the horizontal to the vertical component of the Fourier spectrum for the seismic events recorded at 34 locations during the period October 2003 to August 2004. The method gives reliable data regarding the fundamental frequencies for soil deposits and the results of this experiment allows us to improve the known distribution of T{sub 0}--regularly calculated with the approximate formula T = 4h/v{sub s}. The earthquakes with M{sub w}>4 that occurred on 21.01.2004, 07.02.2004, 17.03.2004 and 04.04.2004 will be used as input to compute H/V ratios for each site of a URS stations in the area of Bucharest city. The H/V ratio is also calculated from noise recordings in the same areas. Computation of H/V spectral ratios are performed by means of the SeismicHandler and J-SESAME software showing the reliability of the method used for the sites located in Bucharest. The fundamental period obtained for the majority of sites is in accordance with already known results. By obtaining the fundamental period for much more and different spots situated in the Bucharest area we covered the zones where these data did not exist before. This study is significant in seismic risk mitigation for the Bucharest city area, for a safer seismic design and for the improvement of microzonation efforts.

Balan, Stefan F.; Cioflan, Carmen O.; Apostol, Bogdan F.; Tataru, Dragos; Grecu, Bogdan [National Institute for Earth Physics, Calugareni 12, PO Box MG2, Bucharest-Magurele (Romania)

2008-07-08T23:59:59.000Z

227

II. RACE AND POVERTY IN METROPOLITAN SCHOOLS……………………………14 III. A NEW GOVERNANCE STRUCTURE: THE EMERGENCE OF CHARTER  

E-Print Network (OSTI)

Education. The Institute on Race and Poverty (IRP) is solely responsible for the content of this report. 0 The Cowen Institute for Public Education Initiatives provided the Institute on Race and Poverty with extensive feedback on the report. Appendix 1 includes

Minnesota Law School

2010-01-01T23:59:59.000Z

228

Onondaga County Department of Water Environment Protection: Process Optimization Saves Energy at Metropolitan Syracuse Wastewater Treatment Plant  

SciTech Connect

This DOE Industrial Technologies Program spotlight describes how Onondaga County, New York, is saving nearly 3 million kWh and 270 million Btu annually at a wastewater treatment plant after replacing inefficient motors and upgrading pumps.

Not Available

2005-12-01T23:59:59.000Z

229

Bay Area Transportation Decision Making in the Wake of ISTEA: Planning Styles in Conflict at the Metropolitan Transportation Commission  

E-Print Network (OSTI)

1998 STIP . . . . . . . . . . . . . . . . . . . . . . . .Improvement Program (STIP) by passing a package of billsImprovement Program (STIP), and what technical studies of

Innes, Judith E.; Gruber, Judith

2001-01-01T23:59:59.000Z

230

Access to jobs : transportation barriers faced by low-skilled autoless workers in U.S. metropolitan areas  

E-Print Network (OSTI)

One of the major concerns in today's urban labor market is spatial mismatch, the geographic separation between jobs and workers. Although numerous studies examine spatial mismatch, most of them focus on inner-city minorities, ...

Kawabata, Mizuki, 1972-

2002-01-01T23:59:59.000Z

231

Project identification and evaluation techniques for transportation infrastructure : assessing their role in metropolitan areas of developing countries  

E-Print Network (OSTI)

Project identification and evaluation of transportation infrastructure play a vital role in shaping and sustaining the forms of cities all over the world. These cities differ substantially in character and urban form and ...

Kumar, Vimal, S.M. Massachusetts Institute of Technology

2009-01-01T23:59:59.000Z

232

Urban Canopy Modeling of the New York City Metropolitan Area: A Comparison and Validation of Single- and Multilayer Parameterizations  

Science Conference Proceedings (OSTI)

High-resolution numerical simulations are conducted using the Coupled Ocean–Atmosphere Mesoscale Prediction System (COAMPS) with two different urban canopy parameterizations for a 23-day period in August 2005 for the New York City (NYC) ...

Teddy Holt; Julie Pullen

2007-05-01T23:59:59.000Z

233

Section 2: Landscapes of Capital - On Big Beaver Road: Detroit and the Diversity of American Metropolitan Landscapes  

E-Print Network (OSTI)

Center near Ann Arbor, Detroit News, April 12, 2005, p. 8.on Southern Plant,” Detroit News, October 28, 2006, p. 3.Pro?le: Michigan 2005 (Detroit: Southeast Michigan Council

Fishman, Robert

2007-01-01T23:59:59.000Z

234

Lori Laitman and Sara Teasdale: A Performer's Guide to The Metropolitan Tower and Other Songs, Mystery, and The Years.  

E-Print Network (OSTI)

??American composer, Lori Laitman, has published over fifty works for solo voice and piano. She has become an important contributor to contemporary art song composition,… (more)

Mueller, Andrea

2009-01-01T23:59:59.000Z

235

An Investigation into the Spatial Variability of Near-Surface Air Temperatures in the Detroit, Michigan, Metropolitan Region  

Science Conference Proceedings (OSTI)

On an annual basis, heat is the chief cause of weather-related deaths in the United States. Therefore, understanding the temperature structure where people live is important for reducing the health burden imposed by hot weather. This study focused ...

Evan M. Oswald; Richard B. Rood; Kai Zhang; Carina J. Gronlund; Marie S. O’Neill; Jalonne L. White-Newsome; Shannon J. Brines; Daniel G. Brown

2012-07-01T23:59:59.000Z

236

The Effect of Urban Street Gang Densities on Small Area Homicide Incidence in a Large Metropolitan County, 1994–2002  

E-Print Network (OSTI)

43 Two hundred eighty-nine zip code tabulation areas existedWe selected 255 of those zip codes to merge with homicideanalysis. We excluded zip codes with very low populations

Robinson, Paul L.; Boscardin, W. John; George, Sheba M.; Teklehaimanot, Senait; Heslin, Kevin C.; Bluthenthal, Ricky N.

2009-01-01T23:59:59.000Z

237

Approaches to the Spatial Modelling of Cancer Incidence and Mortality in Metropolitan Perth, Western Australia, 1990 -2005.  

E-Print Network (OSTI)

??Cancer is one of potentially preventable and treatable diseases. Cancer analysis from different perspectives is necessary to provide the information for health research and the… (more)

Shao, Changying

2011-01-01T23:59:59.000Z

238

From Shrinking Cities to Toshi no Shukush?: Identifying Patterns of Urban Shrinkage in the Osaka Metropolitan Area  

E-Print Network (OSTI)

Osaka], CNRS Editions. Beauregard R. 2003 Voices of Decline.from inner cities (Beauregard 2003). In mature industrial

Buhnik, Sophie

2010-01-01T23:59:59.000Z

239

Municipal Annexation and Metropolitan Colonialism at the Nation's Fringe: San Ysidro, San Diego and the U-S///Mexico Border  

E-Print Network (OSTI)

Reviews 6: 465-498. nd Beauregard, Robert. 2001. Voices ofrise to suburban spaces. Robert Beauregard argues that theout and forming suburbs. Beauregard notes that this shift

Hernandez, Roberto

2006-01-01T23:59:59.000Z

240

Executive Summary The Morgantown metropolitan statistical area (MSA) continues to be a force for growth in West  

E-Print Network (OSTI)

year growth. Leisure and hospitality includes motels/hotels, bars and restaurants, as well as local at a slower pace, as investments in hotels/motels in the region generate future job gains. Finally Corporation www.bber.wvu.edu This conference is made possible by the following underwriters: Chesapeake Energy

Mohaghegh, Shahab

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

A Modification to the NOAH LSM to Simulate Heat Mitigation Strategies in the New York City Metropolitan Area  

Science Conference Proceedings (OSTI)

A new approach to simulating the urban environment with a mesocale model has been developed to identify efficient strategies for mitigating increases in surface air temperatures associated with the urban heat island (UHI). A key step in this ...

Barry H. Lynn; Toby N. Carlson; Cynthia Rosenzweig; Richard Goldberg; Leonard Druyan; Jennifer Cox; Stuart Gaffin; Lily Parshall; Kevin Civerolo

2009-02-01T23:59:59.000Z

242

Characterizing the fabric of the urban environment: A case study of Metropolitan Chicago, Illinois and Executive Summary  

E-Print Network (OSTI)

UT and Sacramento, CA. ..22 Tablefor three cities: Sacramento, CA, Salt Lake City, UT, andfabric of Salt Lake City, UT, Sacramento, CA and Chicago,

Akbari, Hashem; Rose, Leanna Shea

2001-01-01T23:59:59.000Z

243

The Changing Industrial Composition of Manufacturing-Based Regions, 1980-2005  

E-Print Network (OSTI)

2005. Unlike analyses of aggregate metropolitan job growth,analysis shows which metropolitan areas had high, low, or moderate job

Howard Wial

2008-01-01T23:59:59.000Z

244

QCD THERMODYNAMICS WITH NF=2+1 NEAR THE CONTINUUM LIMIT AT REALISTIC QUARK MASSES.  

Science Conference Proceedings (OSTI)

We report on our study of QCD thermodynamics with 2 + 1 flavors of dynamical quarks. In this proceeding we present several thermodynamic quantities and our recent calculation of the critical temperature. In order to investigate the thermodynamic properties of QCD near the continuum limit we adopt improved staggered (p4) quarks coupled with tree-level Symanzik improved glue on N{sub t} = 4 and 6 lattices. The simulations are performed with a physical value of the strange quark mass and light quark masses which are in the range of m{sub q}/m{sub s} = 0.05 - 0.4. The lightest quark mass corresponds to a pion mass of about 150 MeV.

UMEDA, T.

2006-07-23T23:59:59.000Z

245

Centr um voor Wi skunde en I nf or mati ca Modelling, AnalysisandSimulation  

E-Print Network (OSTI)

. . . . . . . . . . . . . . . . . . . . . . . . . . 31 iii #12;Contents CAFE Final Report Volume II III Protocols 33 6 Notation and De nitions 35 6.1 and Simulation CAFE project _ Final report volume II Secure protocols and architecture Edited by A. Bosselaers, R;CAFE Project - Final Report Volume II Secure Protocols and Architecture Edited by A. Bosselaers, R

Schoenmakers, Berry

246

e its go right to the heart nf the basis on which  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

gas at the low- est cost-of-service to U.S. consumers-probably below the cost of imported oil and substantially below the costs of other fuel alter- natives. The average price of...

247

Effects of water chemistry on NF/RO membrane structure and performance  

E-Print Network (OSTI)

dioxane…. ……………… 3.4. Water chemistry: Concentration, pH,4.3.1. Effect of water chemistry on membrane water4.3.2. Effect of water chemistry on EG rejection…………………. …..

Mo, Yibing

2013-01-01T23:59:59.000Z

248

Review of NF-IDS Targets Work Programme Status C. Densham, RAL, 17 November 2009  

E-Print Network (OSTI)

and services ? e) Cost of mercury system ? f) Cost of remote handling systems including shielding required ? g implications for TS shielding CJD, OC, PL (RAL) 4.3.7 Investigate remote handling concepts and cost Dump iv. Time to repair/replace target system, Remote Handling complexity v. Maintenance intervals vi

McDonald, Kirk

249

A Combined NF-IDS and EUROnu Targets Work Programme Chris Densham, Marco Zito, Harold Kirk  

E-Print Network (OSTI)

i. Target system active volume ­ civil engineering, shielding and building costs ii. Remote handling and services e) Cost of mercury system f) Cost of remote handling systems including shielding required g) Any implications for TS TBD #12;shielding 4.3.10 Investigate remote handling concepts, reliability and cost RE

McDonald, Kirk

250

Effects of water chemistry on NF/RO membrane structure and performance  

E-Print Network (OSTI)

water by GAC adsorption, Desalination, 210 (2007) 215-224. [with strong oxidants, Desalination, 176 (2005) 37-45. [49]water RO membranes, Desalination, 235 (2009) 44-57. [19] G.

Mo, Yibing

2013-01-01T23:59:59.000Z

251

Heavy Quark Physics in Nf = 2 QCD ? CP-PACS Collaboration:  

E-Print Network (OSTI)

We present a preliminary analysis of the heavy-heavy spectrum and heavy-light decay constants in full QCD, using a tadpole-improved SW quark action and an RG-improved gauge action on a 16 3 × 32 lattice with four sea quark masses corresponding to m?/m? ? 0.8, 0.75, 0.7, 0.6 and a ?1 ? 1.3 GeV. We focus particularly on the effect of sea quarks on these observables. 1.

unknown authors

1998-01-01T23:59:59.000Z

252

Insights from reconstructing cellular networks in transcription, stress, and cancer  

E-Print Network (OSTI)

M. & Ghosh, S. Crosstalk in NF-kB signaling pathways. Natcomprehensive characterization of NF-kB family DNA binding.12 CHAPTER 1 NF-kB

Ke, Eugene Yunghung; Ke, Eugene Yunghung

2012-01-01T23:59:59.000Z

253

_MainReportGM  

NLE Websites -- All DOE Office Websites (Extended Search)

Events Performed Electricity Consumed (AC MWh) Phoenix, AZ Metropolitan Area 524 59,284 456.28 Tucson, AZ Metropolitan Area 145 16,694 119.53 Los Angeles, CA Metropolitan Area 528...

254

CtjNf.~1'-1'6....r .:tt33 J C7b/(j7/IS-  

E-Print Network (OSTI)

University Princeton, New Jersey 08540 (Submitted to the XVIII Conf. in High-Energy Physics, Tbilisi, USSR

McDonald, Kirk

255

On the Use of Thermal NF3 as the Fluorination and Oxidation Agent in Treatment of Used Nuclear Fuels  

SciTech Connect

This paper presents results of our investigation on the use of nitrogen trifluoride as the fluorination or fluorination/oxidation agent for use in a process for separating valuable constituents from used nuclear fuels by employing the volatility of many transition metal and actinide fluorides. Nitrogen trifluoride is less chemically and reactively hazardous than the hazardous and aggressive fluorinating agents used to prepare uranium hexafluoride and considered for fluoride volatility based nuclear fuels reprocessing. In addition, nitrogen trifluoride’s less aggressive character may be used to separate the volatile fluorides from used fuel and from themselves based on the fluorination reaction’s temperature sensitivity (thermal tunability) rather than relying on differences in sublimation/boiling temperature and sorbents. Our thermodynamic calculations found that nitrogen trifluoride has the potential to produce volatile fission product and actinide fluorides from candidate oxides and metals. Our simultaneous thermogravimetric and differential thermal analyses found that the oxides of lanthanum, cerium, rhodium, and plutonium fluorinated but did not form volatile fluorides and that depending on temperature volatile fluorides formed from the oxides of niobium, molybdenum, ruthenium, tellurium, uranium, and neptunium. We also demonstrated near-quantitative removal of uranium from plutonium in a mixed oxide.

Scheele, Randall D.; McNamara, Bruce K.; Casella, Andrew M.; Kozelisky, Anne E.

2012-05-01T23:59:59.000Z

256

Journal of Membrane Science 256 (2005) 134142 Characterization of novel acid-stable NF membranes before and after  

E-Print Network (OSTI)

studies, artificial aquifer storage and recovery, waterflood surveillance, gas production and CO2. Brady, C. L. V. Aiken, and J. E. Seib- ert, 2007, The 4D mictogravity method for waterflood surveillance

Freger, Viatcheslav "Slava"

257

QCD thermodynamics with $N_f=2+1$ near the continuum limit at realistic quark masses  

E-Print Network (OSTI)

We report on our study of QCD thermodynamics with 2+1 flavors of dynamical quarks. In this proceeding we present several thermodynamic quantities and our recent calculation of the critical temperature. In order to investigate the thermodynamic properties of QCD near the continuum limit we adopt improved staggered (p4) quarks coupled with tree-level Symanzik improved glue on $N_t=4$ and 6 lattices. The simulations are performed with a physical value of the strange quark mass and light quark masses which are in the range of $m_q/m_s=0.05-0.4$. The lightest quark mass corresponds to a pion mass of about 150 MeV.

Takashi Umeda

2006-10-03T23:59:59.000Z

258

Burned Area Emergency Response (BAER) Assessment FINAL Specialist Report – GEOLOGIC HAZARDS Station Fire, Angeles N.F.  

E-Print Network (OSTI)

Three USFS BAER Team geologists assessed increased risks from geologic hazards within the 161,000 acre Station Fire. Watershed response to moderate and high severity burned areas will depend on storm intensity and duration, but is likely to be threatening to life, property and natural resources, and costly. Even small storms have a high to severe relative hazard rating for dangerous debris flows across most of the burned area. Most treatments to reduce debris flow risk were deemed not feasible, not effective, and cost prohibitive. Rockfall, debris slides and dry ravel will add additional hazard and sediment bulk to flood flows. Debris basins will fill quickly, and could overtop and damage downstream communities and infrastructure. Debris storage sites are lacking. Abandoned mines are exposed and add additional hazards. Treatment options are few, and warning systems and public education are critical.

Jerry Degraff Geologist; Sierra N. F; Jonathan Yonni; Schwartz Geologist; Angeles N. F

2009-01-01T23:59:59.000Z

259

Low level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts  

E-Print Network (OSTI)

Despite over forty years of investigation on low-level light therapy (LLLT), the fundamental mechanisms underlying photobiomodulation remain unclear. In this study, we isolated murine embryonic fibroblasts (MEF) from ...

Hamblin, Michael R.

260

NMR studies of the transcriptional inhibitor I kappa B alpha and its interaction with the transcription factor NF kappa B  

E-Print Network (OSTI)

correction of random coil NMR chemical shifts. J Am Chem Socproteins by multidimensional NMR. Biochemistry Bax, A. ,ensemble interpretation of NMR dipolar couplings without

Cervantes, Carla F.

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

KT McDonald IDS-NF Plenary Meeting (Glasgow) Apr 19, 2012 1 The High-Power-Target System  

E-Print Network (OSTI)

Cryogenics Diagnostics Controls and Interlocks Health and Safety Mechanical Decommissioning Remote Handling and Hot Cells ######## UScaled from LBNE Buildings, tunnels and Infrastructure ######## Scaled from LBNE,405,475 1.06.06 - Target Utility Systems 10,730,099 1.06.07 - Remote Handling Systems 14,348,362 1

McDonald, Kirk

262

DOI: 10.1126/science.1164265 , 407 (2009);324Science  

E-Print Network (OSTI)

). Similarly, single nucleotide differences in NF-kB binding sequences determine cofactor specificity for NF-kB

Yamamoto, Keith

263

Record Flood-Producing Rainstorms of 17–18 July 1996 in the Chicago Metropolitan Area. Part II: Hydrometeorological Characteristics of the Rainstorms  

Science Conference Proceedings (OSTI)

The rainstorm on 17–18 July 1996 in northern Illinois produced three rainfall records. The 43.0-cm total storm rainfall at Aurora was the greatest point rainfall recorded for storm durations of 24 hours or less in this century in Illinois and ...

James R. Angel; Floyd A. Huff

1999-03-01T23:59:59.000Z

264

A qualitative study of the relationship between disability, access and service provisions on the quality of life of the disabled in the Greater Durban Metropolitan Area.  

E-Print Network (OSTI)

??Disabled people live in a complex world encompassing the same interests and desires that motivate the balance of the earth's population. We have always known… (more)

Konar, Devoshini.

2008-01-01T23:59:59.000Z

265

Evaluation of the Research-Version TMPA Rainfall Estimate at Its Finest Spatial and Temporal Scales over the Rome Metropolitan Area  

Science Conference Proceedings (OSTI)

The focus of this study is the evaluation of the research-version Tropical Rainfall Measuring Mission (TRMM) Multisatellite Precipitation Analysis (TMPA) rainfall product at its finest spatial and temporal resolutions (3-hourly and 0.25° × 0.25°) ...

Gabriele Villarini

2010-12-01T23:59:59.000Z

266

Record Flood-Producing Rainstorms of 17–18 July 1996 in the Chicago Metropolitan Area. Part III: Impacts and Responses to the Flash Flooding  

Science Conference Proceedings (OSTI)

A record-breaking 24-h rainstorm on 17–18 July 1996 was centered on south Chicago and its southern and western suburbs, areas with a population of 3.4 million. The resulting flash flooding in Chicago and 21 suburbs broke all-time records in the ...

Stanley A. Changnon

1999-03-01T23:59:59.000Z

267

Assessing the impacts of feed in tariffs and metering configuration (gross or net), on the payback period for an average solar PV system in metropolitan Melbourne.  

E-Print Network (OSTI)

??With an increasing customer focus on renewable energy and the perceived benefits from widespread solar photovoltaic (PV) generation there has been a rapid increase in… (more)

Bailey, Darren

2009-01-01T23:59:59.000Z

268

Assessment of the Applicability of Cooperative Vehicle-Highway Automation Systems to Bus Transit and Intermodal Freight: Case Study Feasibility Analyses in the Metropolitan Chicago Region  

E-Print Network (OSTI)

Avenue from Austin to Michigan, Pavement markings, LastCenter, Navy Pier, North Michigan Avenue, State Street, thes. It would extend from Michigan Avenue to Clinton Street,

2004-01-01T23:59:59.000Z

269

Formation Mechanisms of the Extreme High Surface Air Temperature of 40.9°C Observed in the Tokyo Metropolitan Area: Considerations of Dynamic Foehn and Foehnlike Wind  

Science Conference Proceedings (OSTI)

A record-breaking high surface air temperature in Japan of 40.9°C was observed on 16 August 2007 in Kumagaya, located 60 km northwest of central Tokyo. In this study, the formation mechanisms of this extreme high temperature event are ...

Yuya Takane; Hiroyuki Kusaka

2011-09-01T23:59:59.000Z

270

This project is to evaluate the benefits of the System-Wide Adaptive Ramp Metering (SWARM) system implemented in the Portland Metropolitan area as  

E-Print Network (OSTI)

Abstract This project is to evaluate the benefits of the System-Wide Adaptive Ramp Metering (SWARM-timed ramp metering to manage traffic congestion during the morning and afternoon peak periods. The SWARM implemented in stages since May 2005 and is operating on six of the seven metered freeway corridors. Results

Bertini, Robert L.

271

Emerging factors associated with the decline of a gray fox population and multi-scale land cover associations of mesopredators in the Chicago metropolitan area.  

SciTech Connect

Statewide surveys of furbearers in Illinois indicate gray (Urocyon cinereoargenteus) and red (Vulpes vulpes) foxes have experienced substantial declines in relative abundance, whereas other species such as raccoons (Procyon lotor) and coyotes (Canis latrans) have exhibited dramatic increases during the same time period. The cause of the declines of gray and red foxes has not been identified, and the current status of gray foxes remains uncertain. Therefore, I conducted a large-scale predator survey and tracked radiocollared gray foxes from 2004 to 2007 in order to determine the distribution, survival, cause-specific mortality sources and land cover associations of gray foxes in an urbanized region of northeastern Illinois, and examined the relationships between the occurrence of gray fox and the presence other species of mesopredators, specifically coyotes and raccoons. Although generalist mesopredators are common and can reach high densities in many urban areas their urban ecology is poorly understood due to their secretive nature and wariness of humans. Understanding how mesopredators utilize urbanized landscapes can be useful in the management and control of disease outbreaks, mitigation of nuisance wildlife issues, and gaining insight into how mesopredators shape wildlife communities in highly fragmented areas. I examined habitat associations of raccoons, opossums (Didelphis virginiana), domestic cats (Felis catus), coyotes, foxes (gray and red), and striped skunks (Mephitis mephitis) at multiple spatial scales in an urban environment. Gray fox occurrence was rare and widely dispersed, and survival estimates were similar to other studies. Gray fox occurrence was negatively associated with natural and semi-natural land cover types. Fox home range size increased with increasing urban development suggesting that foxes may be negatively influenced by urbanization. Gray fox occurrence was not associated with coyote or raccoon presence. However, spatial avoidance and mortality due to coyote predation was documented and disease was a major mortality source for foxes. The declining relative abundance of gray fox in Illinois is likely a result of a combination of factors. Assessment of habitat associations indicated that urban mesopredators, particularly coyotes and foxes, perceived the landscape as relatively homogeneous and that urban mesopredators interacted with the environment at scales larger than that accommodated by remnant habitat patches. Coyote and fox presence was found to be associated with a high degree of urban development at large and intermediate spatial scales. However, at a small spatial scale fox presence was associated with high density urban land cover whereas coyote presence was associated with urban development with increased forest cover. Urban habitats can offer a diversity of prey items and anthropogenic resources and natural land cover could offer coyotes daytime resting opportunities in urban areas where they may not be as tolerated as smaller foxes. Raccoons and opossums were found to utilize moderately developed landscapes with interspersed natural and semi-natural land covers at a large spatial scale, which may facilitate dispersal movements. At intermediate and small spatial scales, both species were found to utilize areas that were moderately developed and included forested land cover. These results indicated that raccoons and opossums used natural areas in proximity to anthropogenic resources. At a large spatial scale, skunk presence was associated with highly developed landscapes with interspersed natural and semi-natural land covers. This may indicate that skunks perceived the urban matrix as more homogeneous than raccoons or opossums. At an intermediate spatial scale skunks were associated with moderate levels of development and increased forest cover, which indicated that they might utilize natural land cover in proximity to human-dominated land cover. At the smallest spatial scale skunk presence was associated with forested land cover surrounded by a suburban matrix. Compared to raccoon

Willingham, Alison N.; /Ohio State U.

2008-01-01T23:59:59.000Z

272

A Square Prism Urban Canopy Scheme for the NHM and Its Evaluation on Summer Conditions in the Tokyo Metropolitan Area, Japan  

Science Conference Proceedings (OSTI)

A single-layered square prism urban canopy (SPUC) scheme for the Japan Meteorological Agency nonhydrostatic model (NHM) was developed. This scheme considers the urban canopy layer with square prism–shaped buildings. The basic concept of this ...

Toshinori Aoyagi; Naoko Seino

2011-07-01T23:59:59.000Z

273

Evaluation of the volatility basis-set approach for the simulation of organic aerosol formation in the Mexico City metropolitan area  

E-Print Network (OSTI)

New primary and secondary organic aerosol modules have been added to PMCAMx, a three dimensional chemical transport model (CTM), for use with the SAPRC99 chemistry mechanism based on recent smog chamber studies. The new ...

Tsimpidi, A. P.

274

Green Buildings in Green Cities: Integrating Energy Efficiency into the Real Estate Industry  

E-Print Network (OSTI)

carbon dioxide emissions among metropolitan areas (generated by climate, commute patterns, and other factors),

Bardhan, Ashok; Kroll, Cynthia A.

2011-01-01T23:59:59.000Z

275

The non-canonical NFkappaB pathway modulates inflammatory signaling by the canonical NFkappaB pathway  

E-Print Network (OSTI)

Nomenclature Initial mM Location IkBa IkBa IkBa:NF-kBIkBa:NF-kB IkBa:IKKIkBa:IKK:NF-kB IkBa mRNA IkBb IkBb IkBb:NF-kB IkBb:NF-?B

Shih, Feng-Sheng

2011-01-01T23:59:59.000Z

276

Curcumin: A Review of Anti-Cancer Properties and Therapeutic Activity in Head & Neck Squamous Cell Carcinoma  

E-Print Network (OSTI)

Curcumin Inhibition of NF-kB activation, Suppression ofand other angionegic decreased NF-kB activation factors, Up-of transcription factor NF-kB is suppressed by curcumin (

Wilken, Reason; Veena, Mysore S; Wang, Marilene B; Srivatsan, Eri S

2011-01-01T23:59:59.000Z

277

Mitochondrial Protein Influx in Low-dose Radiation-mediated Radioprote...  

NLE Websites -- All DOE Office Websites (Extended Search)

radioprotection via activation of the prosurvival network of factor NF-kappa B (NF-kB). We have reported that blocking NF-kB activation is able to inhibit 10cGy x-ray-...

278

Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor  

E-Print Network (OSTI)

1 activity suppresses NF-kB-dependent gene transcription andinhibition suppresses NF-kB- dependent gene transcription inof PARP inhibitors to block NF-kB - mediated inflammatory

2012-01-01T23:59:59.000Z

279

The HB22.7 Anti-CD22 Monoclonal Antibody Enhances Bortezomib-mediated Lymphomacidal Activity in a Sequence Dependent Manner  

E-Print Network (OSTI)

the accumulation of NF-kB [3,4], increased ROS generation [via inhibition of NF-kB activation [29]. Interestingly,by bortezomib also inhibits NF-kB activation [3,4], which in

2011-01-01T23:59:59.000Z

280

Particulate Matter in Polluted Air May IncreaseBiomarkers of Inflammation in Mouse Brain  

E-Print Network (OSTI)

sample and unlabelled NF-kB consensus oligonu- cleotide, NSCendothelial cells: role of NF-kB activation. J Immunol 2001;EN, Krappmann D, Scheidereit C. NF-kB and the innate immune

Bondy, Stephen Bondy C

2005-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Type I Interferon is Not Just for Viruses: Cytosolic Sensing of Bacterial Nucleic Acids  

E-Print Network (OSTI)

the nucleus and assemble with NF-kB and other transcriptionactivation of IRF3/7, NF-kB, and MAP kinases (Yoneyama andtype I IFNs primarily via NF-kB, which synergizes with other

Monroe, Kathryn McGee

2011-01-01T23:59:59.000Z

282

Advances in computational mass spectrometry : phosphoprotoemics and proteogenomics  

E-Print Network (OSTI)

and phosphorylation mediated NF-KB activiation. Four histoneto be activated, or relay the signal. In NF-KB signaling, atranscription factor (NF-KB) is held inactive outside the

Payne, Samuel Harris

2008-01-01T23:59:59.000Z

283

Discovery and characterization of the mechanisms of a vaccinia viral Bcl-2 homolog, F1L, on Inhibition of caspase-9 and NLRP1  

E-Print Network (OSTI)

a stably integrated NF-kB-driven secreted embryonic alkalineprior to VACV infection. NF-kB activation in THP-1-Bluecells (ATCC; InvivoGen), NF-kB activation was evaluated by

Yu, Chi Wang

2010-01-01T23:59:59.000Z

284

Mechanisms of regulation in the interferon factor 3 (IRF- 3) pathway  

E-Print Network (OSTI)

gene induction, whereas NF-kB- dependent gene inductioncytokines through the NF-kB pathway 4 , hinting at theprotein) and leads to NF-kB activation 2 . This pathway is

Limmer, Kirsten

2008-01-01T23:59:59.000Z

285

Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?  

E-Print Network (OSTI)

and one of the key factors implicated has been NF-kB [78].Nuclear translocation of NF-kB is associated withSong et al. inhibited NF-kB selectively in the endothelium

2011-01-01T23:59:59.000Z

286

Effects of melatonin and age on gene expression in mouseCNS using microarray analysis  

E-Print Network (OSTI)

gene contains an activation site for NF-kB (Cowland et al. ,and levels of activated NF-kB increase in murine cortex withThus, increased levels of NF-kB activation in the aged brain

Bondy, Stephen Bondy C

2007-01-01T23:59:59.000Z

287

Sumoylation strategies in regulated repression by nuclear receptors and in function of tumor metastasis suppressor genes  

E-Print Network (OSTI)

links gene expression by NF-kB and ?-amyloid precursorinteracts with and inhibits NF-kB in human colon and breastby KAI1. Since KAI1 is a NF-kB target gene, its message

Cai, Ling

2008-01-01T23:59:59.000Z

288

Activation of nucleic acid-sensing Toll-like receptors requires cleavage by endolysosomal proteases: a mechanism to avoid autoimmunity  

E-Print Network (OSTI)

a) RAW cells expressing an NF-kB luciferase reporter wereTRIF to induce production of NF-kB elicited transcripts andand a plasmid encoding an NF-kB luciferase reporter (with 5

Ewald, Sarah Elisabeth

2010-01-01T23:59:59.000Z

289

Self/Non-self Discrimination by Toll-like Receptor 9  

E-Print Network (OSTI)

cells stably expressing a NF-kB luciferase reporter and thewith LPS or CpG. Bottom, NF-kB luciferase activity measuredcells stably expressing a NF-kB luciferase reporter and TLR9

Mouchess, Maria Luz

2011-01-01T23:59:59.000Z

290

Plant and animal sensors of conserved microbial signatures.  

E-Print Network (OSTI)

a nuclear factor kB (NF-kB) re- sponse, is a key transducerof one human TLR induced NF-kB activation in mammaliansee SOM). Plants do not have NF-kB–related transcrip- tion

Ronald, Pamela C; Beutler, Bruce

2010-01-01T23:59:59.000Z

291

Molecular mechanisms of ligand-dependent repression by the estrogen receptor and derepression by inflammatory signaling  

E-Print Network (OSTI)

links gene expression by NF-kB and b-amyloid precursorsuch as Receptor Activator of NF-kB (RANK), p75 neurotrophinby the p50 ho- modimer of NF-kB DNA binding factors by

Bourk, Eliot Michael

2010-01-01T23:59:59.000Z

292

Protein Kinase CK2 Regulates Cytoskeletal Reorganization during Ionizing Radiation-Induced Senescence of Human Mesenchymal Stem Cells  

E-Print Network (OSTI)

cytokines/chemokines are NF- kB responsive genes. These dataand suggested the possibility of NF-kB activation leadingto secretion of NF-kB responsive chemokines. Cytoskeleton

Wang, Daojing

2010-01-01T23:59:59.000Z

293

Evolution of the Oligopeptide Transporter (OPT) family  

E-Print Network (OSTI)

evaluation. Name Publication NF-kB Tian et al. 2005a 173expressed mutant IkB blocking NF-kB signaling (labeled “based selection in (a) NF-kB dataset, (b) ALL dataset, (c)

Gomolplitinant, Kenny Matee

2010-01-01T23:59:59.000Z

294

Toll-like Receptor Signaling and its Effects on Microbial Pathogenesis  

E-Print Network (OSTI)

of transcription factors (NF-kB, AP-1, IRFs) that coordinatestably expressing an NF-kB- luciferase reporter construct.in robust induction of NF-kB, which we attributed to

Arpaia, Nicholas

2011-01-01T23:59:59.000Z

295

Sample-Specific Cancer Pathway Analysis Using PARADIGM  

E-Print Network (OSTI)

cation of response to QNZ (an NF-KB inhibitor) in the breastfor the combination of QNZ (an NF-KB inhibitor) and E2F3.studies have shown that NF-KB may activate E2F family

Benz, Stephen Charles

2012-01-01T23:59:59.000Z

296

Trichoepithelioma  

E-Print Network (OSTI)

that negatively regulates NF-kB activation by TNFR familycomponent proteins in the NF-kB and JNK signaling pathways.regulate the cytokine-induced NF-kB pathway for cellular

Johnson, Hillary; Robles, Mirin; Kamino, Hideko; Walters, Ruth F; Lee, Arnold; Sanchez, Miguel

2008-01-01T23:59:59.000Z

297

Slide 1  

National Nuclear Security Administration (NNSA)

1 DEMO Career Paths and Pay Bands 1 DEMO Career Paths and Pay Bands Career Paths Salary ranges for employees in D.C. Metropolitan Area (D.C., Baltimore, Northern VA, Eastern West Virginia and Southern Pennsylvania) Engineering and Scientific (NN) Band 01 $34,075 - $60,765 Band 02 $51,630 - $81,204 Band 03 $74,872 - $115,742 Band 04 $105,211 - $155,500 Professional, Technical, and Administrative (NQ) Band 01 $34,075 - $60,765 Band 02 $51,630 - $97,333 Band 03 $89,033 - $136,771 Band 04 $123,758 To $155,500 Technical and Administrative Support (NU) Band 01 $22,115 - $39,590 Band 02 $34,075 - $60,765 Band 03 $51,630 To $67,114 Nuclear Materials Courier (NV) Band 01 $46,745 - $73,917 Band 02 $62,467 To $81,204 Band 03 $74,872 To $97,333 Band 04 $89,033 To 115,742 Future Leader (NF) Band 01 $34,075 - $60,765 Band 02 $51,630 - $81,204 Band 03 $74,872 -

298

Z. Geomorph. N.F. Suppl.-Vol.146 235-251 Berlin Stuttgart November 2006 Geologic Impacts of the 2004 Indian OceanTsunami on Indonesia,  

E-Print Network (OSTI)

of the 2004 Indian OceanTsunami on Indonesia, Sri Lanka, and the Maldives Bruce M. Richmond, Bruce E in the eastern Indian Ocean near northern Sumatra, Indonesia.The resulting tsunami was measured globally and had.1) with an epicenter located under the seafloor in the eastern Indian Ocean near northern Sumatra, Indonesia

299

Alternative Fuels Data Center: Compressed Natural Gas (CNG) Vehicle Rebate  

Alternative Fuels and Advanced Vehicles Data Center (EERE)

Compressed Natural Gas Compressed Natural Gas (CNG) Vehicle Rebate - Metropolitan Utilities District to someone by E-mail Share Alternative Fuels Data Center: Compressed Natural Gas (CNG) Vehicle Rebate - Metropolitan Utilities District on Facebook Tweet about Alternative Fuels Data Center: Compressed Natural Gas (CNG) Vehicle Rebate - Metropolitan Utilities District on Twitter Bookmark Alternative Fuels Data Center: Compressed Natural Gas (CNG) Vehicle Rebate - Metropolitan Utilities District on Google Bookmark Alternative Fuels Data Center: Compressed Natural Gas (CNG) Vehicle Rebate - Metropolitan Utilities District on Delicious Rank Alternative Fuels Data Center: Compressed Natural Gas (CNG) Vehicle Rebate - Metropolitan Utilities District on Digg Find More places to share Alternative Fuels Data Center: Compressed

300

Computational tools based on energy landscape theory to predict structurally diverse ensembles of transcription factors  

E-Print Network (OSTI)

E. (2004) Thermodynamics and kinetics of the nf-kb/ikband nf-kb/dna interactions, Biophysical Journal 86, 513a. [

Lätzer, Joachim

2007-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
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301

Metabolic Regulation by Lipid Activated Receptors  

E-Print Network (OSTI)

of iKB, which limits Nf-KB signaling(31, 32). PPAR ?VCAM expression through nf-kb and AP1 signaling when taken

Ruby, Maxwell A.

2010-01-01T23:59:59.000Z

302

A High-throughput Screening Approach Identifies Selective Regulators of Il12b Transcription  

E-Print Network (OSTI)

TLR4, in contrast to NF-kB and AP-1, whose activities aresignaling pathways, such as NF-kB and MAP kinase pathways,

Doty, Kevin Richard

2012-01-01T23:59:59.000Z

303

Analysis of Alzheimer's disease severity across brain regions by topological analysis of gene co-expression networks  

E-Print Network (OSTI)

in CF airways Transcription NF-kB signalling pathways Immunesilencing NGF activation of NF-kB EC-MTG Cytoskeleton

Ray, Monika; Zhang, Weixiong

2010-01-01T23:59:59.000Z

304

Shadow Enhancers Provide Precision and Robustness for the Patterning of the Precellular Drosophila Embryo  

E-Print Network (OSTI)

related to mammalian NF-kB. Dorsal controls DV patterningfactor related to mammalian NF-kB (Rushlow et al. 1989; Roth

Perry, Michael W.

2011-01-01T23:59:59.000Z

305

Structural Studies of Calcium/Calmodulin Depenedent Protein Kinase II Activation  

E-Print Network (OSTI)

activation. For example, NF-kB and Ras have been shown toet al. , 2005), and the NF-kB pathway (Dolmetsch et al. ,

Chao, Luke H.

2010-01-01T23:59:59.000Z

306

Pancreatitis and pancreatic cancer in two large pooled case–control studies  

E-Print Network (OSTI)

released during pancreatitis, NF-KB, IL-8, COX-2, and TNF-54]. The involvement of NF-KB is of particular interest as

Bracci, Paige M.; Wang, Furong; Hassan, Manal M.; Gupta, Samir; Li, Donghui; Holly, Elizabeth A.

2009-01-01T23:59:59.000Z

307

Anakinra-responsive lichen planus in a woman with Erdheim-Chester disease: a therapeutic enigma  

E-Print Network (OSTI)

cyclosporine A on TLRA/NF-kB signaling pathway activation inof the pro-inflammatory, NF-kB-dependent cytokines: TNF-

Cohen, Philip R; Kurzrock, Razelle

2014-01-01T23:59:59.000Z

308

Conference Highlights of the 15th International Conference on Human Retrovirology: HTLV and Related Retroviruses,4-8 June 2011, Leuven, Gembloux, Belgium  

E-Print Network (OSTI)

subcellular localization and NF-kB activation. RetrovirologyTax sumoylation in Tax-induced NF-kB activation in T cells.

2011-01-01T23:59:59.000Z

309

NK1 (substance P) receptor  

E-Print Network (OSTI)

nuclear factor- kappaB (NF-kB) and leads to the productionits expression is controlled by NF-kB (Patel et al. 2005;

Goldsmith, Laura E; Kwatra, Madan M

2012-01-01T23:59:59.000Z

310

Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress  

E-Print Network (OSTI)

Signaling pathway: Nrf2 MAPK NF-kB Genetic response:ARE AP NF-kB Mitochondrial perturbation PT pore Figure 4

Araujo, Jesus A; Nel, Andre E

2009-01-01T23:59:59.000Z

311

Epidermal growth factor (EGF)-mediated DNA-binding activity of AP-1 is attenuated in senescent human epidermal keratinocytes  

E-Print Network (OSTI)

of microtubes activated NF-kB. J Cell Biol 1995: 128: 1111–regulation of wound healing? NF-kB activation in cultured

Shi, B; Isseroff, R R

2005-01-01T23:59:59.000Z

312

Host factor regulation of Toxoplasma gondii growth and differentiation  

E-Print Network (OSTI)

has been shown that the NF-kB subunit p65 is phosphorylatedas a consequence of NF-kB signaling upon parasite

Weilhammer, Dina

2010-01-01T23:59:59.000Z

313

SUSAN K. BROWN Department of Sociology (949) 824-9382  

E-Print Network (OSTI)

Foundation. 2004-2005. "Immigration and Intergenerational Mobility in Metropolitan Los Angeles." Co. 2002. "Immigration and Intergenerational Mobility in Metropolitan Los Angeles" (pilot study). Co, Susan. 2004. Beyond the Immigrant Enclave: Network Change and Assimilation. New York: LFB Scholarly

Stanford, Kyle

314

Life-cycle Energy and Emissions Inventories for Motorcycles, Diesel Automobiles, School Buses, Electric Buses, Chicago Rail, and New York City Rail  

E-Print Network (OSTI)

Buses, and Metropolitan Rail  Mikhail Chester and Arpad Buses, and Metropolitan Rail  Mikhail Chester and Arpad 2005, Metra (2005)]  Metra Rail, 2005.  Available Daily 

Chester, Mikhail; Horvath, Arpad

2009-01-01T23:59:59.000Z

315

Towards connecting base stations over metro gigabit ethernets  

Science Conference Proceedings (OSTI)

Deployment of Gigabit Ethernets in metropolitan areas creates new opportunities to save costs by converging data and telephone services. The primary question of our study is whether emerging metropolitan networks can meet the QoS requirements necessary ...

Rainer Baumann; Ulrich Fiedler

2006-08-01T23:59:59.000Z

316

Supporting Photovoltaics in Market-Rate Residential New Construction: A Summary of Programmatic Experience to Date and Lessons Learned  

E-Print Network (OSTI)

Metropolitan Edison Sustainable Energy Fund, PennsylvaniaElectric Company Sustainable EnergyFund, Sustainable Energy Fund of Central Eastern

Barbose, Galen; Wiser, Ryan; Bolinger, Mark

2006-01-01T23:59:59.000Z

317

A Survey of Utility Experience with Real Time Pricing  

E-Print Network (OSTI)

Edison)79 Exelon (Commonwealth Edison) and The Community Energy82 FirstEnergy (Metropolitan Edison and Pennsylvania

Barbose, Galen; Goldman, Charles; Neenan, Bernie

2004-01-01T23:59:59.000Z

318

Nitrogen dynamics of storm runoff in the riparian zone of a forested ...  

Science Conference Proceedings (OSTI)

suggested that scientists should focus on how water chemistry is altered ...... Metropolitan Toronto and Region Conservation Authority for access to.

319

5, 40834113, 2005 Black Carbon  

E-Print Network (OSTI)

ACPD 5, 4083­4113, 2005 Black Carbon Specific Absorption in the Mexico City Metropolitan Area J. C and Physics Discussions Measurements of Black Carbon Specific Absorption in the Mexico City Metropolitan Area License. 4083 #12;ACPD 5, 4083­4113, 2005 Black Carbon Specific Absorption in the Mexico City Metropolitan

Paris-Sud XI, Université de

320

Race, Citizenship, and the Negotiation of Space: Chinese, Japanese, and Mexicans in Fresno, California, 1870-1949  

E-Print Network (OSTI)

Window:  Confronting  Concentrated  Poverty  Across   America,”  in  Brooking Institution and Metropolitan Policy Program (Washington, DC,Window:  Confronting Concentrated Poverty Across America,”  in  Brooking Institution and Metropolitan Policy Program (Washington, DC,Window:  Confronting  Concentrated   Poverty Across America. ” Brooking Institution and Metropolitan Policy Program (Washington, DC,

Guzmán, Christina Morales

2012-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

PI3 Kinase Signals BCR-Dependent Mature B Cell Survival  

E-Print Network (OSTI)

and BAFF-R signal B cellsurvival? UponBAFFengagement,theBAFF-R signalsmainly through the alternative NF-kB can activate the canonical NF-kB signaling pathway and mature B cells require canonical NF-kB signals) to propose a model in which mature B cell survival is based on an NF-kB-mediated crosstalk between BCR

322

Presence of Terminal EPIYA Phosphorylation Motifs in Helicobacter pylori CagA Contributes to IL-8 Secretion,  

E-Print Network (OSTI)

Ba phosphorylation and confirmed CagA involvement in NF-kB activation. Furthermore, we observed that presence of EPIYA-C functional phosphorylation motifs contributed to NF-kB activation. NF-kB upstream signaling-/- mouse embryonic fibroblasts (MEFs) failed to induce NF-kB activity, unlike the respective control MEFs

323

S:\VM3\RX97\TBL_LIST.WPD  

U.S. Energy Information Administration (EIA) Indexed Site

Million U.S. Households, 1997 Housing Unit Characteristics RSE Column Factor: Total Four Most Populated States RSE Row Factors New York California Texas Florida 0.4 1.1 1.1 1.2 1.7 Total .............................................................. 101.5 6.8 11.5 7.0 5.9 NF Census Region and Division Northeast ..................................................... 19.7 6.8 -- -- -- NF New England ............................................. 5.3 Q -- -- -- NF Middle Atlantic ........................................... 14.4 6.8 -- -- -- NF Midwest ....................................................... 24.1 -- -- -- -- NF East North Central ..................................... 16.9 -- -- -- -- NF West North Central .................................... 7.2 -- -- -- -- NF South ...........................................................

324

Hydrogen & Fuel Cells | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Metropolitan Edison Company SEF Loans (FirstEnergy Territory) Metropolitan Edison Company SEF Loans (FirstEnergy Territory) FirstEnergy (formerly GPU) established the Metropolitan Edison Company Sustainable Energy Fund in 2000 with an initial contribution of $5.7 million. The fund later received an additional contribution of $2.5 million as a result of the merger between GPU Energy and FirstEnergy, bringing the total to $8.2 million. The fund is administered by the Berks County Community Foundation. The majority of funding available from the Metropolitan Edison Company SEF takes the form of investments made in businesses pursuing one or more of the fund's objectives. October 16, 2013 Metropolitan Edison Company SEF Grants (FirstEnergy Territory) FirstEnergy (formerly GPU) established the Metropolitan Edison Company

325

Plasmacytoid Dendritic Cells Are Crucial for the Initiation of Inflammation  

E-Print Network (OSTI)

downstream signaling pathways, in which the activation of the transcription factor nuclear factor kB (NF-kB) results in the production of proinflammatory cytokines, whereas the acti- vation of inhibitor of NF-kB (Ik

Gleeson, Joseph G.

326

Molecular Cell STAT3 Activation of miR-21 and miR-181b-1  

E-Print Network (OSTI)

cells via a positive feedback loop involving NF-kB, Lin28, let-7, and IL-6. We identify differentially, respectively, inhibit PTEN and CYLD tumor suppressors, leading to increased NF-kB activity required to maintain

Bulyk, Martha L.

327

Molecular Cell OTULIN Restricts Met1-Linked Ubiquitination  

E-Print Network (OSTI)

of IkBa, leading to nuclear translocation of nuclear factor kB (NF-kB) transcription factors. Together with transcription factors activated by MAP kinases, NF-kB promotes expression of genes that orchestrate

Komander, David

328

10.1101/gad.1936910Access the most recent version at doi: 2010 24: 1533-1545Genes Dev.  

E-Print Network (OSTI)

al. 2009). Studies with NF-kB (Leung et al. 2004) and glucocorticoid receptor (Meijsing et al. 2009- coid receptor and NF-kB affects the regulatory output of the bound complex, suggesting that small

329

Feiqiao Brian Yu 2012.03.16  

E-Print Network (OSTI)

individual cell (5). Another example deals with the study of NF-kB expression in mouse fibroblast cells (5). (B) Contrary to previous studies, NF-kB expression in mouse fibroblast cells occur digitally

Bejerano, Gill

330

Molecular mechanisms integrating genetic and calcium activity-dependent neurotransmitter specification  

E-Print Network (OSTI)

adhesion molecule vii NFAT NF-kB NFY Ngn1/2 NMDA NT p-cJuncontrast, activation of the NF-kB transcription factor by Ca

Kurtz, Lisa Miriam

2010-01-01T23:59:59.000Z

331

Worksheet  

U.S. Energy Information Administration (EIA) Indexed Site

of",6,5,"Aliant Energy Corp.","NF",1,,,30,30 8245,"Hastings City of",6,6,"Mid America Energy Co.","NF",14,,,561,561 8245,"Hastings City of",6,7,"Manitoba Hydro...

332

Worksheet  

U.S. Energy Information Administration (EIA) Indexed Site

Energy Trading","NF",270,,,15700,15700 9130,"Hutchinson Utilities Comm",6,6,"Manitoba Hydro Power","NF",299,,,4535,4535 9130,"Hutchinson Utilities Comm",6,7,"MidAmerica...

333

Dynamic Chromatin Localization of Sirt6 Shapes Stress-and Aging-Related Transcriptional Networks  

E-Print Network (OSTI)

control. Sirt6 can interact with the stress-responsive transcription factor NF-kB and regulate some NF-kB upon stress-signaling. The majority of genes bound by NF-kB subunit RelA recruit Sirt6, and dynamic of NF-kB signaling in stress response and aging. Citation: Kawahara TLA, Rapicavoli NA, Wu AR, Qu K

Quake, Stephen R.

334

A new indicator for breast cancer relapse identified http://www.eurekalert.org/pub_releases/2012-06/idm-ani061912.php[19/06/2012 16:38:11  

E-Print Network (OSTI)

the signalling of a protein complex called NF-kB, which is related to tumour progression. The activation of NF-kB, although the NF-kB complex is an essential requirement for it to remain active chronically-3-3 sigma and/or the activation of NF-kB in tumour cells as a factor in prognosis and diagnosis, as well

Foissac, Sylvain

335

A New Family of Synthetic Diterpenes that Regulates Cytokine Synthesis by Inhibiting IkBa  

E-Print Network (OSTI)

factors, col- lectively referred to as nuclear factor-kappa B (NF-kB).[4] In its resting state, NF-kB- flammatory stimuli induce phosphorylation of IkB leading to dissociation of NF-kB from its inhibitors. Once separated from IkB, NF-kB translocates into the nucleus, binds to the target DNA, and initiates gene

Theodorakis, Emmanuel

336

Molecular Cell Crystal Structures of the TRAF2: cIAP2  

E-Print Network (OSTI)

. They are crit- ical for canonical and noncanonical NF-kB signaling pathways. Here, we report the crystal-associated factors (TRAFs) in NF-kB and MAP kinase activation pathways in the signaling of multiple receptor families and the noncanon- ical NF-kB signaling pathways. In the noncanonical NF-kB signaling pathway, TRAF2 and cIAP1

Wu, Hao

337

Molecular discrimination of structurally equivalent Lys63-linked and linear polyubiquitin chains  

E-Print Network (OSTI)

: ubiquitin linkage; deubiquitinase; ubiquitin binding domain; NF-kB signalling; TAK1/IKK/NEMO/NF-kB EMBO (inhibitor of kB kinase) pathway to nuclear factor-kappaB (NF-kB; Adhikari et al, 2007). TAK1 has been shown leads to the activation of IKK by TAK1 and subsequent NF-kB signalling (Adhikari et al, 2007

Komander, David

338

letters to nature 90 NATURE |VOL 406 |6 JULY 2000 |www.nature.com  

E-Print Network (OSTI)

that GSK-3b function is required for the NF-kB-mediated anti-apoptotic response to TNF-a. Our data also . Immunoblotting was carried out with I-kB-a (polyclonal, New England Biolabs), p65 NF-kB (polyclonal, Santa Cruz of either NF-kB-speci®c oligonu- cleotide probe containing two tandem NF-kB-binding sites (59

Davis, Trisha N.

339

To explore further the anti-inflammatory mech-anisms of PGRN and Atsttrin, we investigated  

E-Print Network (OSTI)

the role of PGRN and Atsttrin in the TNFa- induced activation of IKK (IkB kinase)­IkB­ NF-kB (nuclear). Treatment of BMDMs with rhPGRN or Atsttrin impaired TNFa-induced NF-kB nu- clear translocation, NF-kB binding to the IkBa promoter, and activation of gene expression by NF-kB (Fig. 6, C to F) (33). rh

340

DOI: 10.1126/science.1200840 , 484 (2011);332Science  

E-Print Network (OSTI)

activation of IKK (IkB kinase)­IkB­ NF-kB (nuclear factor kB) signaling. rhPGRN and Atsttrin blocked TNFa-induced NF-kB nu- clear translocation, NF-kB binding to the IkBa promoter, and activation of gene expression by NF-kB (Fig. 6, C to F) (33). rhPGRN and Atsttrin also inhibited the TNFa-induced phosphoryla- tion

Gleeson, Joseph G.

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
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341

A novel derivative of decursin, CSL-32, blocks migration and production of inflammatory mediators and modulates PI3K  

E-Print Network (OSTI)

and modulates PI3K and NF-kB activities in HT1080 cells Seung-Hee Lee*, Jee Hyun Lee{ , Eun-Ju Kim*, WonB), phosphorylation of p65 subunit of NF-kB (nuclear factor-kB) and nuclear translocation of NF-kB, which are required. Keywords: cytokine; inflammation; invasion; NF-kB; signal transduction 1. Introduction Decursin

Lee, Won-Ha

342

A chicken c-Rel-estrogen receptor chimeric protein shows conditional nuclear localization, DNA binding, transformation and transcriptional  

E-Print Network (OSTI)

and dierentiation will potentially dier depend- ing on the level of expression. Keywords: c-Rel; NF-kB, Gerondakis et al., 1996). Structurally, c-Rel belongs to a larger family of transcription factors, the Rel/NF-kB family, which also includes RelA, RelB, NF-kB1, NF-kB2, Dorsal, Dif, and Relish. All members

Â?urovec, Michal

343

Massachusetts Clean Air Act (Massachusetts)  

Energy.gov (U.S. Department of Energy (DOE))

The Act contains regulations to prevent the pollution and contamination of the atmosphere. The Act establishes a contiguous metropolitan pollution control district, comprised of towns in the...

344

Design of Optimal Coasting Speed for MRT Systems by Considering Social Cost.  

E-Print Network (OSTI)

??The Mass Rapid Transit (MRT) systems have been built in many metropolitans to solve the public transportation problem such as traffic congestion. With such high… (more)

Hsieh, Ching-Ho

2006-01-01T23:59:59.000Z

345

Occupant Emergency Plans  

Energy.gov (U.S. Department of Energy (DOE))

On this page is the collection of Emergency Procedures documents for the Department of Energy, Headquarters buildings, in the Washington, DC, metropolitan area.

346

NETL F 451.1-1/1 Categorical Exclusion (CX) Designation Form  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

1209 - 1213 Omaha, NE Midwest Region Alternative Fuels Project NEPA approval for one CNG Vehicle Refueling Appliance (VRA) to be installed at Metropolitan Community College in...

347

Locating American Manufacturing:  

Science Conference Proceedings (OSTI)

... future of manufacturing in America but also ... as defined in the North American Industry Classification ... about two thirds of American metropolitan areas ...

2013-07-31T23:59:59.000Z

348

Gender and Computing Work in the Late 1990s  

E-Print Network (OSTI)

Panteli,A. Stack,J. Ramsay,H. Atkinson,M.P. Presented at The Gender, Work and Organization Conference, Manchester Metropolitan University

Panteli, A.; Stack, J.; Ramsay, H.; Atkinson, M.P.

349

A survey of state clean energy fund support for biomass  

E-Print Network (OSTI)

the Metropolitan Edison Sustainable Energy Fund” http://Kane. “Met-Ed Penelec Sustainable Energy Fund: Semi-AnnualAnnual_Report.pdf Sustainable Energy Fund of Central Eastern

Fitzgerald, Garrett; Bolinger, Mark; Wiser, Ryan

2004-01-01T23:59:59.000Z

350

Penelec SEF of the Community Foundation for the Alleghenies Loan...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

to project FirstEnergy (formerly GPU) established the Metropolitan Edison Company Sustainable Energy Fund and the Penelec Sustainable Energy Fund in 2000. The Community...

351

Using Cool Roofs to Reduce Energy Use, Greenhouse Gas Emissions...  

NLE Websites -- All DOE Office Websites (Extended Search)

roofs on commercial buildings in the Metropolitan Hyderabad region, corresponding to cooling energy savings of 10 19%. With the assumption of an annual increase...

352

Participatory Music Making and Affinity in Washington, DC Irish Sessions.  

E-Print Network (OSTI)

??The Washington, DC metropolitan area hosts a vibrant Irish music scene. Like those in many Irish sessions found throughout the world, the District's network of… (more)

Flynn, Erin Michele

2011-01-01T23:59:59.000Z

353

Rethink DC Metro Stations.  

E-Print Network (OSTI)

??This thesis intends to rethink the role of Metro stations in the Washington Metropolitan Area. It considers Metro stations as more than infrastructure, but with… (more)

Leung, Yathim

2009-01-01T23:59:59.000Z

354

Where the Heart Is? A Geographic Analysis of Working-class Cultures in Detroit Neighborhoods, 1953  

E-Print Network (OSTI)

Peterson 1954. City of Detroit Election Commission. 1952.Precinct Level. Microfilm. Detroit City Hall. Clawson, Dan.You!" Footnotes 24:1,4. Detroit Metropolitan Area Traffic

Stepan-Norris, Judith; Southworth, Caleb

2000-01-01T23:59:59.000Z

355

Hungry for Respect: Discrimination among Adults Using Emergency Food Services  

E-Print Network (OSTI)

and mental health in the Detroit metropolitan area. JournalAmerican women in Detroit: results from a longitudinal2004). Validation of the Detroit Area Study Discrimination

Gee, Gilbert C.; Lively, Kathryn J.; Larsen, Larissa; Keith, Jennifer; Stone, Jana; MacLeod, Kara

2007-01-01T23:59:59.000Z

356

Paul Waddell  

NLE Websites -- All DOE Office Websites (Extended Search)

for operational planning purposes in a variety of U.S. metropolitan areas such as Detroit, Houston, Phoenix, Salt Lake City, San Francisco, and Seattle, as well as...

357

Table 3. Top Five Retailers of Electricity, with End Use Sectors...  

U.S. Energy Information Administration (EIA) Indexed Site

Corp","Investor-Owned",15992689,10452664,4185504,1346875,7646 "4. Metropolitan Edison Co","Investor-Owned",13585688,5653878,4597757,3334053,"-" "5. Pennsylvania Electric...

358

Microsoft Word - JEA CFB PPA Draft for HQ ReviewFinal.doc  

NLE Websites -- All DOE Office Websites (Extended Search)

in September 1996, York County Energy Partners and Metropolitan Edison Company terminated activities on the CFB project. On August 26, 1997, DOE approved transfer of the project to...

359

Flux Measurements of Volatile Organic Compounds from an Urban Tower Platform.  

E-Print Network (OSTI)

??A tall tower flux measurement setup was established in metropolitan Houston, Texas, to measure trace gas fluxes from both anthropogenic and biogenic emission sources in… (more)

Park, Chang Hyoun

2011-01-01T23:59:59.000Z

360

Argonne Chemical Sciences & Engineering - 2008 Awards  

NLE Websites -- All DOE Office Websites (Extended Search)

of Chicago-Argonne Distinguished Performance Award, Lynda Soderholm Excellence in Catalysis Award from the Metropolitan Catalysis Society of New York, Jeff Miller 25...

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Today in Energy - U.S. Energy Information Administration (EIA)  

U.S. Energy Information Administration (EIA)

Petroleum products demand data revised at regional level. June 27, 2013 ... EIA initiates daily gasoline availability survey for metropolitan New York. October 18, 2012

362

Application of the soil and water assessment tool in a tropical agricultural catchment of the Panama Canal watershed implications for its use in watershed management activities.  

E-Print Network (OSTI)

??The Panama Canal Watershed (PCW) provides water to operate the Canal, generate hydroelectricity, and supply water provisions to the local and metropolitan populations. With a… (more)

Oestreicher, Jordan

2008-01-01T23:59:59.000Z

363

Serum 25-hydroxyvitamin D and risk of breast cancer  

E-Print Network (OSTI)

The relationship of solar radiation to cancer mortality ininvolving exposure to solar radiation. Prev Med. 1990;19:and amount of solar radiation in 49 US metropolitan areas

Mohr, Sharif Burgette

2012-01-01T23:59:59.000Z

364

NETL F 451.1-1/1 Categorical Exclusion (CX) Designation Form  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

PMCPower and Vehicle Tech. Div. 09 S. Richardson 382010 - 372015 Marrow, GA DeKalb CountyMetropolitan Atlanta Alternative Fuel and Advanced Technology Vehicle...

365

NETL F 451.1-1/1 Categorical Exclusion (CX) Designation Form  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

PMCPower and Vehicle Tech. Div. 09 S. Richardson 382010 - 372015 Morrow, GA DeKalb CountyMetropolitan Atlanta Alternative Fuel and Advanced Technology Vehicle...

366

La variedad linguistica de la mujer del Area Metropolitana de San Juan, Puerto Rico.  

E-Print Network (OSTI)

??This is an empirical study which aims at describing the speech of women in the Metropolitan Area of San Juan, Puerto Rico. Despite the fact… (more)

Pratt-Panford, Comfort

2012-01-01T23:59:59.000Z

367

Management of building energy consumption and energy supply network on campus scale.  

E-Print Network (OSTI)

??Building portfolio management on campus and metropolitan scale involves decisions about energy retrofits, energy resource pooling, and investments in shared energy systems, such as district… (more)

Lee, Sang Hoon

2012-01-01T23:59:59.000Z

368

NETL F 451.1-1/1 Categorical Exclusion (CX) Designation Form  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Fuels Project Installation of electric charging infrastructure for electric & plug-in hybrid vehicles at various locations in the Kansas City Metropolitan Area. Grant...

369

The Geographic Concentration of Manufacturing Across the ...  

Science Conference Proceedings (OSTI)

... Howard, AR 44% 40% Rural Whitley, IN 44% 30% Metropolitan ... List of All Counties with Manufacturing Share above 20 percent, 2010 ... County ...

2013-07-31T23:59:59.000Z

370

Brazil: desafios de las politicas para las familias  

E-Print Network (OSTI)

Significance of Skin Color in Brazil, Princeton Universityof Gender Inequality- in Brazil, 1914-1940. Bercovich. A„and Demography in Brazil: the Case of the Metropolitan Area

Goldani, Ana Maria; Lazo, Aida Verdugo

2007-01-01T23:59:59.000Z

371

Clean Cities: Greater Washington Region Clean Cities coalition  

Alternative Fuels and Advanced Vehicles Data Center (EERE)

Capitol Chapter, National Association of Fleet Administrators (NAFA); Chair of the Audit Committee, NAFA; and Chair of the Alternative Fuels Vehicle Committee, Metropolitan...

372

Weather and emotional state: a search for associations between weather and calls to telephone counseling services.  

E-Print Network (OSTI)

??Calls to four telephone counseling services, or "hotlines", each serving communities in a major metropolitan area of the United States (Detroit, Washington DC, Dallas and… (more)

Stillman, Daniel Noah

2012-01-01T23:59:59.000Z

373

Implementing Innovation in Planning Practice: The Case of Travel Demand Forecasting  

E-Print Network (OSTI)

Urban Travel Demand Forecasting Project. Institute ofTRB. Metropolitan Travel Forecasting: Current Practice andPurvis. Regional Travel Forecasting Model System for the San

Newmark, Gregory Louis

2011-01-01T23:59:59.000Z

374

From Elevated Freeway to Linear Park: Land Price Impacts of Seoul, Korea's CGC Project  

E-Print Network (OSTI)

2001 ~ 2006). Seoul, Korea. National Statistical Office,2000 and 2005. Dae-jeon, Korea. Polinsky, M. and Shavell,CGC Project. Seoul, Korea. Seoul Metropolitan Government (

Kang, Chang Deok; Cervero, Robert

2008-01-01T23:59:59.000Z

375

Huawei Technologies Co  

Science Conference Proceedings (OSTI)

... SFP+ Enhanced Small Form-Factor Pluggable ... business continuity and disaster recovery sites, metropolitan ... any grease, dirt, or oil before applying ...

2013-03-19T23:59:59.000Z

376

Sandia National Laboratories: Locations: Albuquerque, New Mexico...  

NLE Websites -- All DOE Office Websites (Extended Search)

Housing Sandia is within easy commuting distance of neighborhoods in the Albuquerque metropolitan area and nearby communities. Residents have a broad choice of housing - from lofts...

377

U.S. Energy Market Outlook - Energy Information Administration  

U.S. Energy Information Administration (EIA)

emergency survey 9 Adam Sieminski November 29, 2012 Source: EIA Emergency Gasoline Availability Survey . New York City metropolitan area gas station ...

378

Joel L.Pomerantz1 , Elissa M.Denny and  

E-Print Network (OSTI)

@caltech.edu NF-kB is a critical target of signaling downstream of the T cell receptor (TCR) complex, but how TCR sig- naling activates NF-kB is poorly understood. We have developed an expression cloning strategy that can identify catalytic and noncatalytic molecules that par- ticipate in different pathways of NF-kB

Baltimore, David

379

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative  

E-Print Network (OSTI)

Regulation of Noncanonical NF-kB Signaling Irving C. Allen,1 Justin E. Wilson,1 Monika Schneider,2 John D of NLR proteins, including NLRP12, inhibits the transcription factor NF-kB, although physiologic and disease-rele- vant evidence is largely missing. Dysregulated NF-kB activity is associated with colonic

380

Tea Pigments Inhibit the Production of Type 1 (TH1) and Type 2 (TH2) Helper T Cell Cytokines  

E-Print Network (OSTI)

been linked to their capacity to inhibit the activation of nuclear factor-kB (NF-kB), a transcription. The current study examines the requirement for NF-kB in the immunosuppressive effects mediated by tea require NF-kB for gene expression, such as interleukin-2 (IL-2) and interferon gamma (IFN g

Brand, Paul H.

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Transcriptomic Analysis of Host Immune and Cell Death Responses Associated with the Influenza A Virus PB1-F2  

E-Print Network (OSTI)

-apoptotic properties of PB1-F2. Using a NF-kB luciferase adenoviral vector, we were able to quantify in vivo the implication of NF-kB in the inflammation mediated by the influenza virus infection; we found that PB1-F2 expression intensifies the NF-kB activity. Finally, we quantified the neutrophil recruitment within

Paris-Sud XI, Université de

382

Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene  

E-Print Network (OSTI)

. IKK3 acti- vates the nuclear factor-kappaB (NF-kB) path- way in both cell lines and breast cancers. These observations suggest a mechanism for NF-kB activation in breast cancer, implicate the NF-kB pathway

383

Melatonin Alters Age-Related Changes in Transcription Factors and Kinase Activation  

E-Print Network (OSTI)

not to alter the extent of NF-kB or AP-1 activation [14]. X-in the spleen, dietary a NF-kB activity (densitometic units)YC YM OC OM b NF-kB activity (densitometic units) Results

Bondy, Stephen Bondy C

2010-01-01T23:59:59.000Z

384

Molecular Cell, Volume 37 Supplemental Information  

E-Print Network (OSTI)

a gradual increase in NF-kB p65 nuclear concentration. (A) Wild-type HCT 116 cells were stimulated with increasing doses of TNF for 20 minutes. The nuclear translocation of NF-kB was assessed by immunofluorescence that increasing TNF doses induce uniformly increasing nuclear localization of NF-kB in the cell population. (C) We

Bulyk, Martha L.

385

sortium for sharing analysis results; C. Allen and H. McClure of the Yerkes Primate Center, Atlanta, and  

E-Print Network (OSTI)

when citing this paper. Achieving Stability of Lipopolysaccharide-Induced NF-kB Activation Markus W of the transcription factor NF-kB exhibit damped oscillatory behavior when cells are stimulated by tumor necrosis-like receptor 4 (TLR4) causes activation of NF-kB that requires two down- stream pathways, each of which when

Baltimore, David

386

Ah receptor represses acute-phase response gene expression without binding to its cognate response  

E-Print Network (OSTI)

Repression of the nuclear factor-kB (NF-kB) pathway has been extensively researched because of its pivotal NF-kB regulated-gene expression, especially acute-phase genes, such as serum amyloid A (Saa). Using of transcription factors, such as nuclear factor-kB (NF-kB), signal transducer and activator of transcription-3

Perdew, Gary

387

12. McDonald, J. C. & Whitesides, G. M. Poly(dimethylsiloxane) as a material for fabricating microfluidic devices. Accounts Chem. Res. 35, 491499 (2002).  

E-Print Network (OSTI)

macrophage NF-kB activation and contributes to the resolution of inflammation Toby Lawrence1 *, Magali Bebien and IKKb, and controls the activation of NF-kB transcription factors, which play a pivotal role in inflammation2 . Ample evidence indicates that IKKb mediates NF-kB activation in response to pro-inflamma- tory

Nizet, Victor

388

caspase-8 became enzymatically active after TCR stimulation (Fig. 3H and fig. S8G).  

E-Print Network (OSTI)

caspase-8 became enzymatically active after TCR stimulation (Fig. 3H and fig. S8G). Hence, NF-kB activation by antigen receptors requires enzyme activity of full-length caspase- 8. In the NF-kB-receptor signaling and as a selective signal transducer for NF-kB during the early genetic response to an antigen

Kharasch, Evan

389

Cell cycle and DNA damage response regulation by Spy1, and the intersection of FGFR and NFkappaB pathways  

E-Print Network (OSTI)

Bio-Rad). Quantification of NF-kB binding to the probe wasBio-Rad). The average NF-kB binding from three independentBio-Rad). Quantification of NF-kB binding to the probe was

McAndrew, Christopher William

2010-01-01T23:59:59.000Z

390

Acute liver injury upregulates microRNA-491-5p in mice, and its overexpression sensitizes Hep G2 cells for tumour necrosis factor-alpha-induced apoptosis.  

E-Print Network (OSTI)

expression of AFP, hsp-90 and NF-kB. Acknowledgements This90; miRNA, microRNA; NF-kB, nuclear factor-k B; siRNA, short90) and nuclear factor-kB (NF-kB). Overexpression of miRNA-

Wu, Jian; Zern, M A

2010-01-01T23:59:59.000Z

391

Control of Stochastic Gene Expression by Host Factors at the HIV Promoter  

E-Print Network (OSTI)

promoter contains cis- acting Sp1 and NF-kB elements that regulate gene expression via the recruitment lentivirus variants with mutations introduced in the Sp1 and NF-kB elements, we employed flow cytometry, m and reduction in the regulation of histone acetylation and deacetylation. Furthermore, the NF-kB sites exhibit

Schaffer, David V.

392

MEETING ABSTRACT Open Access Predominant role of Tax sumoylation in  

E-Print Network (OSTI)

MEETING ABSTRACT Open Access Predominant role of Tax sumoylation in Tax-induced NF-kB activation of the NF-kB pathway, a property that is required for HTLV-1-induced T cell immortalization. Tax activates the NF-kB pathway by acting both at cytoplasmic and nuclear levels. In the cytoplasm, Tax binds

Paris-Sud XI, Université de

393

Molecular Cell The Structure of the CYLD USP Domain  

E-Print Network (OSTI)

The tumor suppressor CYLD antagonizes NF-kB and JNK signaling by disassembly of Lys63-linked ubiqui- tin al., 2000). CYLD negatively regulates activation of the cell-survival effec- tor NF-kB, a finding for stimulation of NF-kB and JNK in the innate and adaptive immune response (Jin et al., 2007; Zhang et al., 2006

Komander, David

394

The intersection of NFkappaB and fibroblast growth factor receptor signaling pathways  

E-Print Network (OSTI)

Bio-Rad). Quantification of NF-kB binding to the probe wasBio- Rad). The average NF-kB binding from three independentBio-Rad). Quantification of NF-kB binding to the probe was

Drafahl, Kristine A.

2009-01-01T23:59:59.000Z

395

Blood proteolytic activity elevation and plasma protein degradation in spontaneously hypertensive rat models  

E-Print Network (OSTI)

G-protein alpha s, H-Ras, NF-kB, pard6, PI3K cat class IA,G-protein alpha-s, H-Ras, NF-kB, Pi3k cat class IA, PKA-cat,Beta-catenin, MDM2, MMP-2, NF-kb, PIAS2, SUMO- 1, XPA, p21

Chow, Jason C

2011-01-01T23:59:59.000Z

396

Molecular Cell Recruitment of the Linear Ubiquitin Chain Assembly  

E-Print Network (OSTI)

, and is required for efficient TNF-induced activation of NF-kB and JNK, resulting in apoptosis inhibition. Finally-activated protein (MAP) kinase cascades and NF-kB activation (Wajant et al., 2003). Ligand-induced trimerization., 2008). TRAF2 and RIP1 play important roles in the activation of JNK and NF-kB, respectively (Devin et

Komander, David

397

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing  

E-Print Network (OSTI)

-linked (also known as linear) Ub chains that regulate nuclear factor kB (NF-kB) signaling. Deubi by reducing kcat 240-fold. OTULIN overexpression or knockdown affects NF-kB re- sponses to LUBAC, TNFa has roles in NF-kB activation (Haas et al., 2009; Toku- naga and Iwai, 2012; Tokunaga et al., 2009

Komander, David

398

Metabolic disorders in heart diseases with an inflammatory background  

E-Print Network (OSTI)

2010 This editorial refers to `The p65 subunit of NF-kB binds to PGC-1a, linking inflammation. Introduction Cardiac hypertrophy and heart failure are associated with nuclear factor-kB (NF-kB) activation major pathways. 2. Link between NFkB and PGC-1a pathways The general term NF-kB traditionally refers

Paris-Sud XI, Université de

399

Gene Regulation in M Cell Lineages: In Vitro and In Vivo  

E-Print Network (OSTI)

LTbR agonist (Fig 2-1C). The NF-kB gene relB (Relb) has alsoof relB is regulated by NF-kB activation, and the LT?R andreceptors all signal through NF-kB activation, this finding

Wang, Jing

2011-01-01T23:59:59.000Z

400

Specific Recognition of Linear Ubiquitin Chains by NEMO  

E-Print Network (OSTI)

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-kB Activation Simin.03.007 SUMMARY Activation of nuclear factor-kB (NF-kB), a key medi- ator of inducible transcription in immunity, requires binding of NF-kB essential modulator (NEMO) to ubiquitinated substrates. Here, we report

Komander, David

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Cancer Cell A Transcriptional Signature and Common  

E-Print Network (OSTI)

. As in atherosclerosis, oxidized LDL and its receptor OLR1 activate the inflammatory pathway through NF-kB, leading, 2006; De Marzo et al., 2007; Naugler and Karin, 2008; Pierce et al., 2009). Constitutively active NF-kB, and mouse models provide evidence for a causative role of NF-kB in malignant conversion and progression

Bulyk, Martha L.

402

Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune  

E-Print Network (OSTI)

. pneumophila lacking the Dot/Icm system is recognized by Toll-like receptors (TLRs), leading to a canonical NF-kB, thereby preventing synthesis of IkB, an inhibitor of the NF-kB transcription factor. Thus, macrophages infected with wildtype L. pneumophila exhibited prolonged activation of NF-kB, which was associated

Vance,. Russell

403

Cloning and characterization of Dorsal homologues in the hemipteran Rhodnius prolixusimb_909 681..690  

E-Print Network (OSTI)

by transcription factors of the Rel/ Nuclear Factor kappa B (Rel/NF-kB) family. We have cloned and characterized is that of Nuclear Factor kappa B (NF-kB), named after the transcrip- tional activator of the immunoglobulin kappa light chain in human B-lymphocytes (Sen & Baltimore, 1986). A func- tional NF-kB transcription factor

Lowenberger, Carl

404

Received 9 Nov 2012 | Accepted 28 Jan 2013 | Published 5 Mar 2013 Regulation of A20 and other OTU  

E-Print Network (OSTI)

such as activation of protein kinase cascades during NF-kB (nuclear factor-kB) activation2,3. Ub modifications described to regulate the transcription factor NF-kB (ref. 6), activation of which depends on an intricate in hyperinflammatory phenotypes consistent with deregulated NF-kB signalling. Mechanistically, A20 establishes

Komander, David

405

Molecular Cell Noncooperative Interactions between Transcription  

E-Print Network (OSTI)

the definition of anatomical boundaries during development. Here we show that NF-kB, a TF controlling noncoop- eratively. We observed that increasing concentra- tions of NF-kB are translated into gradual by combining quantitative measurements and a minimal physical model of an NF-kB-dependent promoter. We

Bulyk, Martha L.

406

Functional dissection of homeodomain transcription factors HoxA9 and Meis1 in myeloid leukemia : their epigenetic regulation and their downstream targets  

E-Print Network (OSTI)

protein 3. A20. Neg reg Toll/NF-kB signaling Socs3 Cytokine-2, C polypeptide. Adhesion, NF-kB activation Hsd11b1Peli1 Pellino1. Required for NF-kB activation through IL1R

Wang, Gang

2006-01-01T23:59:59.000Z

407

Second SICSA Workshop on Biological Networks: Theory and Applications  

E-Print Network (OSTI)

stimulation, oscillatory MAPK, p53, NF-kB network with optional UV modulation Oscillations have been factor kappa-light-chain-enhancer of activated B cell (NF-kB) is conducted. A candidate for a tumor necrosis factor- (TNF-) controlled stimulation, oscillating MAPK, p53, NF-kB network with optional

Edinburgh, University of

408

ARTICLE doi:10.1038/nature09853 Crystal structure of inhibitorof kB kinase b  

E-Print Network (OSTI)

a similar trimodular architecture and function. Nuclear factor kB (NF-kB) transcription factors are master regulators of inflammatory, immune and apoptotic responses1,2 . In the canonical pathway, NF-kB dimers. When cells are stimulated by NF-kB inducers, IkB proteins are phosphorylated by the Ser

Wu, Hao

409

Table HC1-12a. Housing Unit Characteristics by West Census Region,  

U.S. Energy Information Administration (EIA) Indexed Site

2a. Housing Unit Characteristics by West Census Region, 2a. Housing Unit Characteristics by West Census Region, Million U.S. Households, 2001 Housing Unit Characteristics RSE Column Factor: Total U.S. West Census Region RSE Row Factors Total Census Division Mountain Pacific 0.5 1.0 1.7 1.1 Total .............................................................. 107.0 23.3 6.7 16.6 NE Census Region and Division Northeast ..................................................... 20.3 -- -- -- NF New England ............................................. 5.4 -- -- -- NF Middle Atlantic ........................................... 14.8 -- -- -- NF Midwest ....................................................... 24.5 -- -- -- NF East North Central ..................................... 17.1 -- -- -- NF West North Central ....................................

410

Decay constants of B and D mesons from improved relativistic lattice QCD with two flavours of sea quarks  

E-Print Network (OSTI)

We present a calculation of the B and D meson decay constants in lattice QCD with two (Nf=2) flavours of light dynamical quarks, using an O(a)-improved Wilson action for both light and heavy quarks and a renormalization-group improved gauge action. Simulations are made at three values of lattice spacing a=0.22, 0.16, 0.11 fm and four values of sea quark mass in the range m_PS/m_V \\~= 0.8-0.6. Our estimate for the continuum values of the decay constants are fBd = 208(10)(11) MeV, fBs = 250(10)(13)(^{+8}_{-0}) MeV, fDd = 225(14)(14) MeV, fDs = 267(13)(17)(^{+10}_{-0}) MeV for Nf=2 where the statistical and systematic errors are separately listed, and the third error for fBs and fDs show uncertainty of determination of strange quark mass. We also carry out a set of quenched simulations using the same action to make a direct examination of sea quark effects. Taking the ratio of results for Nf=2 and Nf=0, we obtain fb^{Nf=2}/fb^{Nf=0} = 1.11(6), fbs^{Nf=2}/fbs^{Nf=0} = 1.14(5), fd^{Nf=2}/\\fd^{Nf=0} = 1.03(6), fds^...

Khan, A A; Burkhalter, R; Ejiri, S; Fukugita, M; Hashimoto, S; Ishizuka, N; Iwasaki, Y; Kanaya, K; Kaneko, T; Kuramashi, Y; Manke, T; Nagai, K; Okawa, M; Shanahan, H P; Ukawa, A; Yoshié, T

2001-01-01T23:59:59.000Z

411

6. Chan, F. K., Siegel, M. R. & Lenardo, J. M. Signaling by the TNF receptor superfamily and T cell homeostasis. Immunity 13, 419422 (2000).  

E-Print Network (OSTI)

, T., Green, D. R. & Verma, I. M. Suppression of TNF-a-induced apoptosis by NF-kB. Science 274, 787 functions: JNK activation is not linked to apoptosis while NF-kB activation prevents cell death. Cell 87., Dixit, V. M. & Goeddel, D. V. TRAF2-mediated activation of NF-kB by TNF receptor 2 and CD40. Science 269

Hutchinson, John

412

of May 16, 2013. This information is current as  

E-Print Network (OSTI)

-binding proteins TGF-b­activated kinase 1 (TAK1)­binding protein (TAB)2 and TAB3 are implicated in NF-kB signaling via TAK1 activation. However, TAB2 alone is dispensable for NF-kB activation in embryonic fibroblasts, but not NF-kB, in response to TLR and CD40 stimulation in B cells. Surprisingly, TAB2 and TAB3

413

RELB, A NEW PARTNER OF ARYL HYDROCARBON RECEPTOR-MEDIATED TRANSCRIPTION  

E-Print Network (OSTI)

-00268250,version1-31Mar2008 #12;3 INTRODUCTION The NF-kB/Rel transcription factors play critical roles, and apoptosis. Transcriptionally active NF-kB dimers are formed by combinatorial association of five subunits: p50, RelA (p65), p52, c-Rel, and RelB (1). The classic inducible NF-kB heterodimer consists of the p50

Paris-Sud XI, Université de

414

A jB sequence code for pathway-specific innate immune responses  

E-Print Network (OSTI)

of the NF-kB family of transcription factors, for example, vertebrate p50 and p65 (Ghosh et al, 1998; Karin and Ben-Neriah, 2000; Brennan and Anderson, 2004; Xiao and Ghosh, 2005). In the absence of a stimulus, NF-kB that allow NF-kB factors to enter the nucleus and direct expression of antimicrobial agents and secondary

415

(161), ra11. [DOI: 10.1126/scisignal.2001501]4Science Signaling Benedict, Gourisankar Ghosh and Alexander Hoffmann (22 February 2011)  

E-Print Network (OSTI)

of Interferon Response Elements by NF-kB p50 Christine S. Cheng,1,2,3 Kristyn E. Feldman,1,2 James Lee,1 programs. Members of the nuclear factor kB (NF-kB) and interferon (IFN) regulatory factor (IRF-down and bottom-up systems biology approaches, we have identified the NF-kB p50 homodimer as a regulator of IRF

Hasty, Jeff

416

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3  

E-Print Network (OSTI)

function and NF-kB signaling Di Sha, Lih-Shen ChinÃ? and Lian LiÃ? Department of Pharmacology and CenterB kinase/nuclear factor kB (NF-kB) pathway. Furthermore, the ability of PINK1 to promote parkin-mediated ubiquitin signaling and implicate the deregulation of the PINK1/parkin/NF-kB neuroprotective signaling

Li, Lian

417

www.cell-research.com | Cell Research Guoliang Qing et al.  

E-Print Network (OSTI)

B, inhibitor of NF-kB; IKK, IkB kinase Received 28 September 2006; revised 9 October 2006; accepted 10 October that the IkB kinase (IKK), an essential activator of NF-kB, is selectively degraded by autophagy when Hsp90 and establish a molecular link among Hsp90, NF-kB and autophagy Cell Research (2006) 16:895-901. doi:10.1038/sj

Cai, Long

418

letters to nature NATURE |VOL 414 |13 DECEMBER 2001 |www.nature.com 759  

E-Print Network (OSTI)

±1318 (1999). 2. Khush, R. S., Leulier, F. & Lemaitre, B. Drosophila immunity: two paths to NF-kB. Trends. Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kB receptor-mediated Drosophila immune response requires Dif, an NF-kB factor. Genes Dev. 13, 792±797 (1999

Schnaufer, Achim

419

Molecular Cell Hydrogen Sulfide-Linked Sulfhydration  

E-Print Network (OSTI)

Molecular Cell Article Hydrogen Sulfide-Linked Sulfhydration of NF-kB Mediates Its Antiapoptotic@jhmi.edu DOI 10.1016/j.molcel.2011.10.021 SUMMARY Nuclear factor kB (NF-kB) is an antiapoptotic tran- scription factor. We show that the antiapoptotic actions of NF-kB are mediated by hydrogen sulfide (H2S

Dong, Xinzhong

420

POSTER PRESENTATION Open Access HIV triggers immunoregulatory dendritic cells  

E-Print Network (OSTI)

T cells through the non-canonical NF-kB pathway O Manches1* , MV Fernandez1 , J Plumas2 , L Chaperot2 , N activation of the non-canonical NF-kB pathway in pDC, and is essential for IDO induction. TLR7 triggering-dependent fashion, allowing cDC to induce Treg from naïve CD4+ T cells. Conclusion The non-canonical NF-kB pathway

Paris-Sud XI, Université de

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Epigenetic Upregulation of lncRNAs at 13q14.3 in Leukemia Is Linked to the In Cis Downregulation of a  

E-Print Network (OSTI)

of a Gene Cluster That Targets NF-kB Angela Garding1,2. , Nupur Bhattacharya1.¤a , Rainer Claus3¤b , Melanie NF-kB activity, which we could show after overexpression, siRNA­mediated knockdown, and dominant/16 family of genes at 13q14.3 as the strongest inducers of NF-kB activity. In summary, the tumor suppressor

Rippe, Karsten

422

Molecular Cell Structural Basis for Recognition  

E-Print Network (OSTI)

.01.012 SUMMARY NEMO is the regulatory subunit of the IkB kinase (IKK) in NF-kB activation, and its CC2-LZ region. INTRODUCTION NF-kB proteins are evolutionarily conserved master regulators of immune and inflammatory responses/Thr-specific IkB kinase (IKK) signalosome is at the bottleneck for NF-kB activation because activated IKK

Wu, Hao

423

(290), ra75. [DOI: 10.1126/scisignal.2004097]6Science Signaling Linda C. Hsieh-Wilson and David Baltimore (27 August 2013)  

E-Print Network (OSTI)

Function of the NF-kB Protein c-Rel by O-GlcNAc Glycosylation Parameswaran Ramakrishnan,1 * Peter M. Clark factor nuclear factor kB (NF-kB) rapidly reprograms gene expression in response to various stimuli stress. We report that the NF-kB subunit c-Rel is modified and acti- vated by O-GlcNAcylation. We

Gleeson, Joseph G.

424

Lattice Study of the Conformal Window in QCD-like Theories  

E-Print Network (OSTI)

Using lattice simulations, we study the extent of the conformal window for an $\\text{SU}(3)$ gauge theory with $N_f$ Dirac fermions in the fundamental representation. We present evidence that the infrared behavior is conformal for $12 \\leq N_f \\leq 16$, governed by an infrared fixed point, while confinement and chiral symmetry breaking are present for $N_f \\leq 8$.

Thomas Appelquist; George T. Fleming; Ethan T. Neil

2007-12-04T23:59:59.000Z

425

Table HC1-11a. Housing Unit Characteristics by South Census Region,  

U.S. Energy Information Administration (EIA) Indexed Site

1a. Housing Unit Characteristics by South Census Region, 1a. Housing Unit Characteristics by South Census Region, Million U.S. Households, 2001 Housing Unit Characteristics RSE Column Factor: Total U.S. South Census Region RSE Row Factors Total Census Division South Atlantic East South Central West South Central 0.5 0.9 1.2 1.4 1.4 Total .............................................................. 107.0 38.9 20.3 6.8 11.8 NE Census Region and Division Northeast ..................................................... 20.3 -- -- -- -- NF New England ............................................. 5.4 -- -- -- -- NF Middle Atlantic ........................................... 14.8 -- -- -- -- NF Midwest ....................................................... 24.5 -- -- -- -- NF East North Central .....................................

426

Single-qubit-gate error below 10 in a trapped ion  

Science Conference Proceedings (OSTI)

... computers depends on the ability to accurately control sensitive super- position amplitudes by ... near 1.25 GHz, coupled with a 4-nF capacitor to one ...

2011-10-28T23:59:59.000Z

427

THE LONG TERM CALIBRATION STABILITY OF CRITICAL ...  

Science Conference Proceedings (OSTI)

... through nf flow tubes with circular cross section, ... Real Gas Eflects in Critical Flow through Nozzles ... of the Effects of Heat Transfer and Compressible ...

2012-10-29T23:59:59.000Z

428

Mosaic neurofibromatosis type 1  

E-Print Network (OSTI)

with neurofibromatosis type 1 (NF1) with microdeletionsM, Huson S. Mosaic (segmental) neurofibromatosis type 1and type 2: no longer neurofibromatosis type 5. Am J Med

Liang, Christine; Schaffer, Julie V

2008-01-01T23:59:59.000Z

429

Construction of Risk-Averse Enhanced Index Funds  

E-Print Network (OSTI)

?George Washington University, Washington, DC, 20052, mlejeune@gwu.edu. The author is partially supported by the Grant #. W911NF-09-1-0497 from the ...

430

NVN-079666 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2541.85 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

431

NVN-079352 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1160 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

432

NVN-079665 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2560 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

433

NVN-079668 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2585.51 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

434

NVN-079664 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

435

NVN-074253 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

436

NVN-079307 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

437

NVN-079663 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2213.1 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

438

NVN-079310 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 655 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

439

NVN-074250 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1199 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

440

NVN-074254 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Table 2. Fuel Oil Consumption and Expenditures in U.S. Households ...  

U.S. Energy Information Administration (EIA)

1 A small amount of fuel oil used for appliances is included in "Fuel Oil" under "All Uses." NF = No applicable RSE row factor.

442

BMC Cancer BioMed Central  

E-Print Network (OSTI)

Research article Genistein inhibits radiation-induced activation of NF-?B in prostate cancer cells promoting apoptosis and G2 /M cell cycle arrest

Julian J Raffoul; Yu Wang; Omer Kucuk; Jeffrey D Forman; Fazlul H Sarkar; Gilda G Hillman; Jeffrey D Forman; Fazlul H Sarkar; Gilda G Hillman

2006-01-01T23:59:59.000Z

443

Stuart R Hudson | Princeton Plasma Physics Lab  

NLE Websites -- All DOE Office Websites (Extended Search)

approach for optimizing currents in H-1NF stellarator in operation in the Plasma Research Laboratory at the ANU to control vacuum magnetic islands was introduced. After...

444

Slide 1  

National Nuclear Security Administration (NNSA)

chemistry (AC) and materials characterization (MC) mission work CMR Chemistry and Metallurgy Research CMRR-NF CMR Replacement - Nuclear Facility RLUOB Radiological...

445

Chemistry and Metallurgy Research Replacement - Nuclear Facility...  

National Nuclear Security Administration (NNSA)

Chemistry and Metallurgy Research Replacement - Nuclear Facility (CMRR-NF SEIS) | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing...

446

CACA-014408 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 693.6 Bid PriceAcre Managing Field Office none provided Surface Manager INYO NF Lessee 1...

447

NVN-077646 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 80 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

448

NVN-079667 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1920 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

449

NVN-077647 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 640 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

450

NVN-079276 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 640 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

451

NVN-078687 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLEASENONCOMPETITI Total Acreage 1180 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 REESE...

452

NVN-079291 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1295.88 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

453

NVN-077668 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLEASENONCOMPETITI Total Acreage 3297.94 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 NGP BLUE...

454

CACA-011667 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 1590 Bid PriceAcre Managing Field Office none provided Surface Manager INYO NF Lessee 1...

455

NVN-080159 | Open Energy Information  

Open Energy Info (EERE)

(section) Case Status Authorized Case Type GEOLEASENONCOMPETITI Total Acreage 640 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 NGP BLUE...

456

Die Jontophorese der mit medikamentö  

Science Conference Proceedings (OSTI)

Flora, 131. N.F. 31, 87--112, 1936. Die bevorzugte Aufnahme saurer Farbstoffe bei hoher Wasserstoffionen- konzentration der die Zellen yon Asperffillus niger ...

457

Dynamic Modeling of Behavior Change H. T. Banks, Keri L. Rehm, Karyn L. Sutton  

E-Print Network (OSTI)

chacun des noeuds des deux documents : sds1(r) = snf 1(r) = pr tree Ã? p nf 1 tree + pr paper Ã? pnf 1

458

Control of size and charge selectivity in amphiphilic graft copolymer nanofiltration membranes  

E-Print Network (OSTI)

The throughput and efficiency of membrane separations make polymer filtration membranes an important resource for the pharmaceutical, food and wastewater treatment industries. Nanofiltration (NF) membranes fill an important ...

Lovell, Nathan Gary

2010-01-01T23:59:59.000Z

459

Numerical Investigation of Interaction Between Hydraulic Fractures and Natural Fractures  

E-Print Network (OSTI)

Hydraulic fracturing of a naturally-fractured reservoir is a challenge for industry, as fractures can have complex growth patterns when propagating in systems of natural fractures in the reservoir. Fracture propagation near a natural fracture (NF) considering interaction between a hydraulic fracture (HF) and a pre-existing NF, has been investigated comprehensively using a two dimensional Displacement Discontinuity Method (DDM) Model in this thesis. The rock is first considered as an elastic impermeable medium (with no leakoff), and then the effects of pore pressure change as a result of leakoff of fracturing fluid are considered. A uniform pressure fluid model and a Newtonian fluid flow model are used to calculate the fluid flow, fluid pressure and width distribution along the fracture. Joint elements are implemented to describe different NF contact modes (stick, slip, and open mode). The structural criterion is used for predicting the direction and mode of fracture propagation. The numerical model was used to first examine the mechanical response of the NF to predict potential reactivation of the NF and the resultant probable location for fracture re-initiation. Results demonstrate that: 1) Before the HF reaches a NF, the possibility of fracture re-initiation across the NF and with an offset is enhanced when the NF has weaker interfaces; 2) During the stage of fluid infiltration along the NF, a maximum tensile stress peak can be generated at the end of the opening zone along the NF ahead of the fluid front; 3) Poroelastic effects, arising from fluid diffusion into the rock deformation can induce closure and compressive stress at the center of the NF ahead of the HF tip before HF arrival. Upon coalescence when fluid flows along the NF, the poroelastic effects tend to reduce the value of the HF aperture and this decreases the tension peak and the possibility of fracture re-initiation with time. Next, HF trajectories near a NF were examined prior to coalesce with the NF using different joint, rock and fluid properties. Our analysis shows that: 1) Hydraulic fracture trajectories near a NF may bend and deviate from the direction of the maximum horizontal stress when using a joint model that includes initial joint deformation; 2) Hydraulic fractures propagating with higher injection rate or fracturing fluid of higher viscosity propagate longer distance when turning to the direction of maximum horizontal stress; 3) Fracture trajectories are less dependent on injection rate or fluid viscosity when using a joint model that includes initial joint deformation; whereas, they are more dominated by injection rate and fluid viscosity when using a joint model that excludes initial joint deformation.

Xue, Wenxu

2010-12-01T23:59:59.000Z

460

Town of Airfield : creating a prototype for suburban development at the Naval Air Station site in South Weymouth  

E-Print Network (OSTI)

The accumulation of negative externalities associated with the rapid expansion of many metropolitan areas in the United States suggests that the current suburban development model is no longer a viable option for efficiently ...

Panfil, J. Christoph

1996-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Pseudovertical Temperature Profiles and the Urban Heat Island Measured by a Temperature Datalogger Network in Phoenix, Arizona  

Science Conference Proceedings (OSTI)

As part of an air-quality field campaign conducted in Phoenix, Arizona, during the summer of 2001, a network of temperature dataloggers and surface meteorological stations was deployed across the metropolitan area for a 61-day period. The ...

Jerome D. Fast; Joel C. Torcolini; Randy Redman

2005-01-01T23:59:59.000Z

462

The Urban-related Nocturnal Rainfall Anomaly at St. Louis  

Science Conference Proceedings (OSTI)

Studies during the Metropolitan Meteorological Experiment (METROMEX) sought to define influences of St. Louis on the summer atmosphere that led to alterations in rainfall. These studies defined how city influences caused an afternoon maximum of ...

Stanley A. Changnon Jr.; Floyd A. Huff

1986-12-01T23:59:59.000Z

463

Delimiting “Thunderstorm Watch” Periods by Real-Time Lightning Location for a Power Utility Company  

Science Conference Proceedings (OSTI)

During times of thunderstorm activity, the power utility serving metropolitan New York enters a potentially costly “thunderstorm watch” mode of operation which is designed to prevent a major power outage caused by lightning. To evaluate the ...

Vincent P. Idone; Richard E. Orville

1990-03-01T23:59:59.000Z

464

Air Quality Forecasts in the Mid-Atlantic Region: Current Practice and Benchmark Skill  

Science Conference Proceedings (OSTI)

Air quality forecasts for the mid-Atlantic region (including the metropolitan areas of Baltimore, Washington, D.C., and Philadelphia) began in 1992. These forecasts were issued to the public beginning in 1995 and predict daily peak O3 ...

William F. Ryan; Charles A. Piety; Eric D. Luebehusen

2000-02-01T23:59:59.000Z

465

An Evaluation of Multiscalar Drought Indices in Nevada and Eastern California  

Science Conference Proceedings (OSTI)

Nevada and eastern California are home to some of the driest and warmest climates, most mountainous regions, and fastest growing metropolitan areas of the United States. Throughout Nevada and eastern California, snow-dominated watersheds provide ...

Daniel J. McEvoy; Justin L. Huntington; John T. Abatzoglou; Laura M. Edwards

2012-12-01T23:59:59.000Z

466

Aggregation of U.S. Population Centers Using Climate Parameters Related to Building Energy Use  

Science Conference Proceedings (OSTI)

A technique for aggregating population centers into groups based on selected climate parameters is presented. Climate information on the 125 largest Standard Metropolitan Statistical Areas (SMSAs) in the United States is used to assign each SMSA ...

Brandt Andersson; William L. Carroll; Marlo R. Martin

1986-05-01T23:59:59.000Z

467

BAE/Orion Hybrid Electric Buses at New York City Transit: A Generation...  

NLE Websites -- All DOE Office Websites (Extended Search)

8 truck Cummins Westport ISXG high-pressure, direct- injection, liquefied natural gas (LNG) and diesel Completed in 2004 Host Site Profile-NYCT NYCT is a part of the Metropolitan...

468

A study of illegal housing of Lisbon built in 1974 to 1984 : from description to computation  

E-Print Network (OSTI)

A morphological description of illegal housing built by homeowners in the Metropolitan Area of Lisbon between 1974 and 1984 is presented. This description is based on a parametric set grammar that attempts to formulate ...

Santos Romão, Luís António dos, 1958-

2005-01-01T23:59:59.000Z

469

Analysis of Urban-Rural Solar Radiation Data from St. Louis, Missouri  

Science Conference Proceedings (OSTI)

The results of an analysis of simultaneous measurements of incident solar radiation from six locations in metropolitan St. Louis, Missouri are described. The measurements were taken continuously from September 1975 through March 1977 with ...

James T. Peterson; Thomas L. Stoffel

1980-03-01T23:59:59.000Z

470

Modeling Land Surface Processes and Heavy Rainfall in Urban Environments: Sensitivity to Urban Surface Representations  

Science Conference Proceedings (OSTI)

High-resolution simulations with the Weather Research and Forecasting (WRF) model are used in conjunction with observational analyses to investigate land surface processes and heavy rainfall over the Baltimore-Washington metropolitan area. ...

Dan Li; Elie Bou-Zeid; Mary Lynn Baeck; Stephen Jessup; James A. Smith

471

Managing the implementation of automotive emission control technologies using systems engineering principles  

E-Print Network (OSTI)

In the 1940s and 1950s poor air quality in major metropolitan areas throughout the United States started to negatively influence the health of citizens throughout the country. After numerous studies the government concluded ...

Penney, John, 1974-

2004-01-01T23:59:59.000Z

472

Space–Time Variability of Rainfall and Extreme Flood Response in the Menomonee River Basin, Wisconsin  

Science Conference Proceedings (OSTI)

The hydrometeorological processes that control flash flooding are examined through analyses of space–time rainfall variability and flood response in the Milwaukee metropolitan region. The analyses focus on four flood events in the Menomonee River ...

Yu Zhang; James A. Smith

2003-06-01T23:59:59.000Z

473

Urbanization and Climate Change: An Examination of Nonstationarities in Urban Flooding  

Science Conference Proceedings (OSTI)

We examine the hydroclimatology, hydrometeorology and hydrology of flooding in the Milwaukee metropolitan region of the upper midwest of the US. The objectives of this study are: 1) to assess nonstationarities in flood frequency associated with ...

Long Yang; James A. Smith; Daniel B. Wright; Mary Lynn Baeck; Gabriele Villarini; Fuqiang Tian; Heping Hu

474

Atmospheric Response to Local Upwelling in the Vicinity of New York–New Jersey Harbor  

Science Conference Proceedings (OSTI)

Multiply nested urbanized mesoscale model [Coupled Ocean–Atmosphere Mesoscale Prediction System (COAMPS)] simulations of the New York–New Jersey metropolitan region are conducted for 4–11 July 2004. The simulations differ only in their ...

Julie Pullen; Teddy Holt; Alan F. Blumberg; Robert D. Bornstein

2007-07-01T23:59:59.000Z

475

Inadvertent Weather Modification in Urban Areas: Lessons for Global Climate Change  

Science Conference Proceedings (OSTI)

Large metropolitan areas in North America, home to 65% of the nation's population, have created major changes in their climates over the past 150 years. The rate and amount of the urban climate change approximate those being predicted globally ...

Stanley A. Changnon

1992-05-01T23:59:59.000Z

476

Tornado-Related Deaths and Injuries in Oklahoma due to the 3 May 1999 Tornadoes  

Science Conference Proceedings (OSTI)

During the evening hours of 3 May 1999, 58 tornadoes occurred in Oklahoma. One tornado reached F5 intensity and left a widespread path of death, injury, and destruction in and around the Oklahoma City metropolitan area. Other communities across ...

Sheryll Brown; Pam Archer; Elizabeth Kruger; Sue Mallonee

2002-06-01T23:59:59.000Z

477

If you reside in WASHINGTON, DC - MD -VA - WV your salary will...  

National Nuclear Security Administration (NNSA)

If you are employed in the WASHINGTON, DC Metropolitan Area (D.C., Baltimore, Northern VA, Eastern WV, and Southern PA) your salary will range from: Pay Band Pay Plan(s) Minimum...

478

An overview of the MILAGRO 2006 Campaign: Mexico City emissions and their transport and transformation  

E-Print Network (OSTI)

MILAGRO (Megacity Initiative: Local And Global Research Observations) is an international collaborative project to examine the behavior and the export of atmospheric emissions from a megacity. The Mexico City Metropolitan ...

Molina, Luisa Tan

479

"Arab Americans and Segmented Assimilation: Looking Beyond the Theory to the Reality in the Detroit Metro Area".  

E-Print Network (OSTI)

??This thesis aims to apply Segmented Assimilation Theory to the Arab-American community in Metropolitan Detroit. Segmented assimilation theory relates to second-generation immigrants, and proposes three… (more)

Weaver, Kristin

2010-01-01T23:59:59.000Z

480

Residential segregation and health behavior among Black adults  

E-Print Network (OSTI)

of supermarkets in metropolitan Detroit. Am J Public Health,determinants of health in Detroit. The Millbank Quarterly,86.7% of the Blacks in Detroit, 83.6% of the Blacks in

Corral, Irma

2009-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf metropolitan" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Flexible urbanism  

E-Print Network (OSTI)

This thesis seeks to find a new approach/method towards urbanization in existing low density neighborhoods in major metropolitan cities in the United States. The near South side of the city of Chicago (a city that carries ...

Anandam, Anahita

2006-01-01T23:59:59.000Z

482

Assessment of the potential diversion of air passengers to high-speed rail in the northeast corridor  

E-Print Network (OSTI)

The high level of intercity passenger travel in the Northeast Corridor is supported by densely populated metropolitan city-centers, the suitable distance between the urban areas, and the extent to which economic and social ...

Clarke, Michael D. D.

1994-01-01T23:59:59.000Z

483

The Urban Heat Island of the North-Central Texas Region and its Relation to the 2011 Severe Texas Drought  

Science Conference Proceedings (OSTI)

Hourly surface temperature differences between Dallas-Fort Worth metropolitan and rural sites have been used to calculate the urban heat island from 2001 to 2011. The heat island peaked after sunset, and was particularly strong during the drought ...

A. M. E. Winguth; B. Kelp

484

Impacts of residential developments on local sustainability : case study in Metro Boston  

E-Print Network (OSTI)

Along with urbanization and decentralization, the sustainability of metropolitan areas is considered one of the most significant challenges worldwide. Transportation-related problems, such as congestion, GHG emissions, and ...

Xia, Jie, M.C.P. Massachusetts Institute of Technology

2011-01-01T23:59:59.000Z

485

A Subsynoptic Analysis of the Denver Tornadoes of 3 June 1981  

Science Conference Proceedings (OSTI)

On the afternoon of 3 June 1981 a severe thunderstorm spawned two tornadoes which moved across a portion of metropolitan Denver. The tornadoes were classified as strong F2 intensity, and caused damage totaling over $1 5 million. The synoptic-...

E. J. Szoke; M. L. Weisman; J. M. Brown; F. Caracena; T. W. Schlatter

1984-04-01T23:59:59.000Z

486

Measurements of OH and HO2 concentrations during the MCMA-2006 field campaign – Part 2: Model comparison and radical budget  

E-Print Network (OSTI)

Measurements of hydroxyl (OH) and hydroperoxy (HO2) radicals were made during the Mexico City Metropolitan Area (MCMA) field campaign as part of the MILAGRO (Megacity Initiative: Local and Global Research Observations) ...

Dusanter, S.

487

Intelligent Transportation Systems: Saving Lives, Time and Money Kristin Tufte  

E-Print Network (OSTI)

Intelligent Transportation Systems: Saving Lives, Time and Money Kristin Tufte Portland State University Oregon Transportation Summit Sept 10, 2010 #12;Intelligent Transportation Systems: Saving Lives, Time and Money Official transportation data archive for the Portland-Vancouver metropolitan region

Bertini, Robert L.

488

PORTLAND STATE UNIVERSITY CENTER FOR TRANSPORTATION STUDIES  

E-Print Network (OSTI)

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Transit and Non-Motorized Transport . . . . . . . . . . . . Future Data SourcesPORTLAND STATE UNIVERSITY CENTER FOR TRANSPORTATION STUDIES DEPARTMENT OF CIVIL & ENVIRONMENTAL Transportation System Performance Report June, 2008 #12;2007 Portland Metropolitan Region Transportation System

Bertini, Robert L.

489

The Effect of Building Shadows on the Vertical Temperature Structure of the Lower Atmosphere in Downtown Denver  

Science Conference Proceedings (OSTI)

Denver's Continuous Air Monitoring Program (CAMP) site, typically recording the highest carbon monoxide levels in the metropolitan area; lies within a large region of downtown Denver shadowed by tall buildings. Two studies conducted during the ...

Dominique Ruffieux; Daniel E. Wolfe; Catherine Russell

1990-12-01T23:59:59.000Z

490

Mesoscale and Synoptic Scale Interactions Leading to Intense Convection: The Case of 7 June 1982  

Science Conference Proceedings (OSTI)

A case study is presented involving an unusually intense mesoscale convective system (MCS) which produced extensive hail and wind damage in northeast Kansas and northern Missouri, including the Kansas City metropolitan area, during the predawn ...

Anthony A. Rockwood; Robert A. Maddox

1988-03-01T23:59:59.000Z

491

Application of positive matrix factorization to on-road measurements for source apportionment of diesel- and gasoline-powered vehicle emissions in Mexico City  

E-Print Network (OSTI)

The goal of this research is to quantify diesel- and gasoline-powered motor vehicle emissions within the Mexico City Metropolitan Area (MCMA) using on-road measurements captured by a mobile laboratory combined with positive ...

Thornhill, D. A.

492

A Multivariate Assessment of Meteorological Influences on Inhalable Particle Source Impacts  

Science Conference Proceedings (OSTI)

This paper identifies the sources of fine and coarse inhalable particles at a site in metropolitan Boston and investigates their respective relationships to meteorological conditions. In this work, Principal Component Analysis (PCA) is applied to:...

George D. Thurston; John D. Spengler

1985-11-01T23:59:59.000Z

493

Modeling the impacts of biomass burning on air quality in and around Mexico City  

E-Print Network (OSTI)

The local and regional impacts of open fires and trash burning on ground-level ozone (O[subscript 3]) and fine carbonaceous aerosols in the Mexico City Metropolitan Area (MCMA) and surrounding region during two high fire ...

Lei, W.

494

"For good design, you pay now; for bad design, you pay later"--or do you?  

E-Print Network (OSTI)

What is the value of architectural design on office building income? This empirical study of 296 office building located in 11 Metropolitan Statistical Areas (MSA) hopes to quantitatively determine if a plain vanilla cereal ...

Murugappan, Meena

2006-01-01T23:59:59.000Z

495

Montreal Quebec City Corner Brook Charlottetown Sydney Halifax Saint John Bar Harbor Rockland/Camden Newport New York  

E-Print Network (OSTI)

synergy and fuel the momentum of the entire community. The metropolitan university serves as a gateway surcharge. Flats smaller than the minimum size are non-mailable. minimum size 3.5" x 5" minimum size 3.5" x

Raina, Ramesh

496

NETL F 451.1-1/1 Categorical Exclusion (CX) Designation Form  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

8 Metropolitan Energy Center EE DE-EE0002538 (Clean Cities) PVT - Clean Cities 2010 Kay Kelly (GO) 1209 - 1213 Multiple B20 and E85 sites in KS Midwest Region Alternative Fuels...

497

Laboratory characterization of a highly weathered old alluvium in San Juan, Puerto Rico  

E-Print Network (OSTI)

The old alluvium underlying much of metropolitan San Juan was formed in early Pleistocene and has undergone substantial post-depositional weathering in the tropical climate of Puerto Rico, resulting in a special combination ...

Zhang, Guoping, 1968-

2002-01-01T23:59:59.000Z

498

Magellan at NERSC Progress Report for June 2010  

E-Print Network (OSTI)

NERSC in partnership with ESNet was able to provisionof Magellan to JGI. Using ESnet’s OSCARS [6] and the Scienceare adjacent on the ESnet Bay Area MAN (Metropolitan Area

Broughton, Richard Canon, Lavanya Ramakrishnan, Brent Draney, Jeff

2011-01-01T23:59:59.000Z

499

A Note on the Ichoua et al (2003) Travel Time Model  

E-Print Network (OSTI)

by users in a number of different metropolitan areas in the United States. [2] proposed a ..... with Pij the set of simple paths on G, connecting customer/facility i to.

500

Urban Reclamation in São Paulo  

E-Print Network (OSTI)

The urbanized terrain of São Paulo is characterized by wasteful landscapes on peripheral areas of the metropolitan agglomeration, and decaying landscapes of waste in the core of the city. If on the one hand, the increasingly ...

Eskinazi, Victor

2009-01-01T23:59:59.000Z