National Library of Energy BETA

Sample records for nf metropolitan

  1. The Future Metropolitan Landscape

    E-Print Network [OSTI]

    Bosselmann, Peter; Ruggeri, Deni

    2007-01-01

    The Future Metropolitan Landscape Peter Bosselmann and DeniMetropolitan Landscape The Future Metropolitan Landscape Thecomplex phenomenon of “The Future Metropolitan Landscape. ”

  2. The Metropolitan Water District of Southern California

    Broader source: Energy.gov (indexed) [DOE]

    ERcomments@hq.doe.gov Comments on the Department of Energy's Quadrennial Energy Review: Water-Energy Nexus The Metropolitan Water District of Southern California (Metropolitan) is...

  3. Employee and Student Trip Reduction: First Year Results from Metropolitan Phoenix

    E-Print Network [OSTI]

    Burns, Elizabeth K.

    1994-01-01

    Results from Metropolitan Phoenix Elizabeth K. Bums Workingfrom Metropolitan Phoenix ElizabethK. Burns Department ofCounty Regional metropolitan Phoenix~ Arizona. compared with

  4. Metropolitan Accessibility and Transportation Sustainability:Sustainability

    E-Print Network [OSTI]

    Papalambros, Panos

    Metropolitan Accessibility and Transportation Sustainability:Sustainability: Comparative Reduce (fulfillment of)Promote Sustainability: Meet needs of (fulfillment of) needs present Institute SMART Sustainable Mobility and Accessibility Research andSMART Sustainable Mobility

  5. TNAP, a Novel Repressor of NF-B-inducing Kinase, Suppresses NF-B Activation*

    E-Print Network [OSTI]

    Hu, Wen-Hui

    responses, oncogenesis, apoptosis, and neuronal signaling (1­5). To date two principal pathways for NF- B

  6. U.S. Metropolitan Spatial Structure and Employment Growth 

    E-Print Network [OSTI]

    Huang, Xiaoyan

    2014-08-13

    This study explores the influence of US metropolitan spatial structure evolution on regional employment growth rate. The first part of this study investigates the evolution of US metropolitan spatial structures from 2000 to 2010. At the macro level...

  7. Correction to NF 3 , the greenhouse gas missing from Kyoto

    E-Print Network [OSTI]

    Prather, Michael J; Hsu, Juno

    2010-01-01

    J. Hsu (2008), NF 3 , the greenhouse gas missing from Kyoto,Correction to “NF 3 , the greenhouse gas missing from Kyoto”2010), Correction to “NF 3 , the greenhouse gas missing from

  8. Columbia metropolitan Convention Center Columbia, South Carolina

    E-Print Network [OSTI]

    Valtorta, Marco

    at the Columbia metropolitan Convention Center Columbia, South Carolina marCh 23-25, 2011 Bringing Center 101 linColn Street Bringing Open SOurce tO the SOutheaSt Columbia, South Carolina developerS, edu team member, Rails Bringing Open SOurce tO the SOutheaSt Columbia, South Carolina POSSCON 2010 kicked

  9. Metropolitan Community College (Missouri-all locations)

    E-Print Network [OSTI]

    OF KANSAS Department of Design Photo Media-B.F.A Number to call at KU for advising: (785) 864-3500 Website/Senior level for graduation. Photo Media Requirements: KU Course Requirements Metropolitan Course Equivalents Critical Reading and Writing 3 ENGL 102 Composition and Reading II 3 GE21 GE11 Core: Core ENGL 209 Intro

  10. TransBorder 2035 Metropolitan Transportation Plan 

    E-Print Network [OSTI]

    El Paso Metropolitan Planning Organization

    2007-11-16

    Investigacion y Planeacion (IMIP), Tigua Tribal Government, New Mexico Environmental Department, Texas Commission on Environmental Quality, City of El Paso, and surrounding towns. The MPO staff is tasked with establishing an impartial setting for effective... Metropolitan Planning Organization www.elpasompo.org 3.3 Environmental Justice Environmental Justice (EJ) is a concept that has a major impact in the transportation planning process. The goal of EJ, as it relates to transportation...

  11. Chicago Metropolitan Agency for Planning Data Dashboard | Department...

    Energy Savers [EERE]

    Metropolitan Agency for Planning Data Dashboard More Documents & Publications Austin Energy Data Dashboard Massachusetts -- SEP Data Dashboard Phoenix, Arizona Data Dashboard...

  12. Involuntary Mobility, Gender, and Travel Demand Management in Metropolitan Phoenix

    E-Print Network [OSTI]

    Burns, Elizabeth K.

    1995-01-01

    1988. “Transportation in the Phoenix Metropolitan Area. ” In218. Luckingham, Bradford. 1989. Phoenix: The History of aYear Ending December 31, 1995. Phoenix: Maricopa County Trip

  13. Alexandria/Pineville Metropolitan Transportation Plan MTP 2029 

    E-Print Network [OSTI]

    Rapides Area Planning Commission

    2005-01-01

    stream_source_info Alexandria_Pineville Metropolitan Transportation Plan MTP 2029.pdf.txt stream_content_type text/plain stream_size 90 Content-Encoding ISO-8859-1 stream_name Alexandria_Pineville Metropolitan Transportation Plan MTP...

  14. Metropolitan Road Traffic Simulation on FPGAs.

    SciTech Connect (OSTI)

    Tripp J. L. (Justin L.); Mortveit, H. S. (Henning S.); Hansson, A. A. (Anders A.); Gokhale, M. (Maya)

    2005-01-01

    This work demonstrates that road traffic simulation of entire metropolitan areas is possible with reconfigurable supercomputing that combines 64-bit microprocessors and FPGAs in a high bandwidth, low latency interconnect. Previously, traffic simulation on FPGAs was limited to very short road segments or required a very large number of FPGAs. Our data streaming approach overcomes scaling issues associated with direct implementations and still allows for high-level parallelism by dividing the data sets between hardware and software across the reconfigurable supercomputer. Using one FPGA on the Cray XD1 supercomputer, we are able to achieve a 34.4 x speed up over the AMD microprocessor. System integration issues must be optimized to exploit this speedup in the overall simulation.

  15. Office rent and labor availability in the Chicago Metropolitan Area

    E-Print Network [OSTI]

    Tang, Wencan, M.C.P. Massachusetts Institute of Technology

    2008-01-01

    This paper provides an empirical analysis of office rents using data from the 2000 U.S. Census and TWR office building data in the Chicago Metropolitan Statistical Area. The results indicate that rent levels respond to ...

  16. Transit Access and Regional Coordination in Metropolitan Detroit

    E-Print Network [OSTI]

    LaRose, Jeremiah; Netto, Alyssa; Thomas, Trevor

    2014-01-01

    groups on both sides of Detroit’s borders, and a great dealbadly needed transit service in Detroit. Planetizen, May 22.Coordination in Metropolitan Detroit Jeremiah LaRose, MURP '

  17. Efficient detection of contagious outbreaks in massive metropolitan encounter networks

    E-Print Network [OSTI]

    Sun, Lijun

    Physical contact remains difficult to trace in large metropolitan networks, though it is a key vehicle for the transmission of contagious outbreaks. Co-presence encounters during daily transit use provide us with a city-scale ...

  18. Hot Springs Metropolitan Planning Organization 2030 Long Range Transportation Plan 

    E-Print Network [OSTI]

    Hot Springs Metropolitan Planning Organization

    2005-11-03

    of Mountain Pine Hot Springs Village The Greater Hot Springs Chamber of Commerce The Arkansas State Highway and Transportation Department In Cooperation With United States Department of Transportation Federal Highway Administration Federal Transit... Administration 2030 Long Range Transportation Plan for the Hot Springs Area Metropolitan Planning Organization This LRTP has been funded with federal Metropolitan Planning (PL) funds through the Federal Highway Administration, Section 5303 funds...

  19. NF kappa B expression and matrix metalloproteinase activity in hypertension

    E-Print Network [OSTI]

    Wu, Kwan-I

    2009-01-01

    without PDTC treatment by gelatin gel zymography. Chapter 2Labeling of NF-?B………………………………14 Gelatin Gel ZymographyPDTC treatment measured by gelatin zymography…………………34

  20. Erratum: NF3, the greenhouse gas missing from Kyoto (Geophysical Research Letters (2010) 37 (L11807))

    E-Print Network [OSTI]

    Prather, MJ; Hsu, J

    2010-01-01

    J. Hsu (2008), NF 3 , the greenhouse gas missing from Kyoto,Correction to “NF 3 , the greenhouse gas missing from Kyoto”2010), Correction to “NF 3 , the greenhouse gas missing from

  1. Sustainable metropolitan growth strategies : exploring the role of the built environment

    E-Print Network [OSTI]

    Diao, Mi, Ph. D. Massachusetts Institute of Technology

    2010-01-01

    The sustainability of metropolitan areas has been considered one of the most significant social challenges worldwide. Among the various policy options to achieve sustainable metropolitan growth, smart-growth strategies ...

  2. Governing the metropolis : the evolution of cooperative metropolitan governance in Mexico City's public transportation

    E-Print Network [OSTI]

    Cenizal, Callida

    2015-01-01

    What enables cooperation at the metropolitan scale? This thesis explores public transportation planning in the Mexico City metropolitan area (MCMA) for empirical evidence to better understand what institutional, financial, ...

  3. DeKalb County/Metropolitan Atlanta Alternative Fuel and Advanced...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    60tifrancis2012o.pdf More Documents & Publications DeKalb CountyMetropolitan Atlanta Alternative Fuel and Advanced Technology Vehicle Project DeKalb CountyMetropolitan...

  4. DeKalb County/Metropolitan Atlanta Alternative Fuel and Advanced...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    vt060francis2010p.pdf More Documents & Publications DeKalb CountyMetropolitan Atlanta Alternative Fuel and Advanced Technology Vehicle Project DeKalb CountyMetropolitan...

  5. DeKalb County/Metropolitan Atlanta Alternative Fuel and Advanced...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    60tifrancis2011p.pdf More Documents & Publications DeKalb CountyMetropolitan Atlanta Alternative Fuel and Advanced Technology Vehicle Project DeKalb CountyMetropolitan...

  6. Cloning and expression of equine NF-kB2 

    E-Print Network [OSTI]

    Mirhosseini, Negin

    2009-05-15

    ........................ 51 xi LIST OF TABLES Page Table 1 Primers to generate full length NF-?B2... of the interaction between EIAV S2 and equine NF-?B in the yeast two hybrid system........................... 43 Table 7 Primers and probes for quantitative PCR.......................................... 48 1 CHAPTER I INTRODUCTION 1 Equine Infectious...

  7. Baskerville, C. A.; and Merguerian, Charles, 1982, Tectonic history of the New York Metropolitan area.

    E-Print Network [OSTI]

    Merguerian, Charles

    Baskerville, C. A.; and Merguerian, Charles, 1982, Tectonic history of the New York Metropolitan area. Urban field mapping of basement (literally in some cases) rocks in the New York Metropolitan area: Baskerville, C. A.; and Merguerian, Charles, 1982, Tectonic history of the New York Metropolitan area (abs

  8. Fargo-Moorhead Metropolitan Flood Risk Management Feasibility Study

    E-Print Network [OSTI]

    US Army Corps of Engineers

    Fargo-Moorhead Metropolitan Flood Risk Management Feasibility Study North Dakota and Minnesota Quality Bulletin for Peer Review released December 16, 2004. This flood risk management feasibility study flood risk management and recreation needs of the study area in February 2010. An IEPR of the draft

  9. The structure of agriculture in metropolitan and nonmetropolitan America 

    E-Print Network [OSTI]

    Scott, Michelle L

    2003-01-01

    the following questions: (1) What was the structure of U.S. agricultural production systems in 1992 and had this structure changed by 1997? (2) What was the relationship between metropolitan proximity and U.S. agristructure and its changes from 1992 to 1997...

  10. Pricing Schemes for Metropolitan Traffic Data Markets Negin Golrezaei1

    E-Print Network [OSTI]

    Shahabi, Cyrus

    Marshall School of Business, University of Southern California, Los Angeles, CA 90089 {golrezae, nazerzad of the pricing schemes applicable to data marketplaces in the context of transportation traffic data. Traffic congestion is a growing problem in many metropolitan areas. It not only wastes our time and energy

  11. Effects of water chemistry on NF/RO membrane structure and performance

    E-Print Network [OSTI]

    Mo, Yibing

    2013-01-01

    potable water and seawater desalination. NF/RO are effectivemembranes under seawater conditions, Desalination, 247 (

  12. NF 3 , the greenhouse gas missing from Kyoto

    E-Print Network [OSTI]

    Prather, Michael J; Hsu, Juno

    2008-01-01

    of high-GWP, long-lived, greenhouse gases like NF 3 shouldbe included in the national greenhouse gas inventories onceto expand the list of greenhouse gases for the second

  13. NF-?B Fans the Flames of Lung Carcinogenesis

    E-Print Network [OSTI]

    Jacks, Tyler E.

    This perspective on Deng et al. (beginning on p. 424 in this issue of the journal) examines the link between NF-?B and lung tumorigenesis. Experiments in genetically engineered mouse models of lung cancers are elucidating ...

  14. Car Based Transport and Transit Oriented Metropolitan —— Chinese Urban Motorization Pathways

    E-Print Network [OSTI]

    Ximing, Lu

    2008-01-01

    Car Based Transport and Transit Oriented Metropolitan ——the automobile, the result is that car ownership has becomeof American families lack cars. In China, however, large

  15. Washington Metropolitan Area Transit Authority: Compressed Natural Gas Transit Bus Evaluation

    SciTech Connect (OSTI)

    Chandler, K.; Eberts, E.; Melendez, M.

    2006-04-01

    Evaluates compressed natural gas (CNG) powered transit buses at Washington Metropolitan Area Transit Authority (WMATA), providing a comparison between them and standard diesel transit buses.

  16. The Origins of Metropolitan Transportation Planning in Travel Demand Forecasting, 1944-1962

    E-Print Network [OSTI]

    Deutsch, Cheryl

    2013-01-01

    predictions for the Detroit area. In Highway Research Board4: Desire line charts from Detroit, 1942………………………………………………….transportation research in the Detroit Metropolitan Area

  17. A gradient analysis of urban landscape pattern: a case study from the Phoenix metropolitan region, Arizona, USA

    E-Print Network [OSTI]

    Wu, Jianguo "Jingle"

    A gradient analysis of urban landscape pattern: a case study from the Phoenix metropolitan region the spatial pattern of urbanization in the Phoenix metropolitan area, Arizona, USA. Several landscape metrics

  18. Haploid reporter screens aimed at identification of NF-kappaB regulators

    E-Print Network [OSTI]

    Lee, Clarissa Ci

    2014-01-01

    Nuclear factor-kappaB (NF-KB) is a family of transcription factors that are essential for execution of both the innate and the adaptive immune response. NF-KB regulates hundreds of genes involved in critical processes such ...

  19. Topographically-Based Real-Time Traffic Anomaly Detection in a Metropolitan Highway System

    E-Print Network [OSTI]

    Grossman, Robert

    Topographically-Based Real-Time Traffic Anomaly Detection in a Metropolitan Highway System Rajmonda metropolitan area. Our Chicago Alert System (CAS) considers both the spatial and temporal aspects of the data of attack, the need for real-time traffic management is crucial. Real-time traffic management encompasses

  20. Photochemical age determinations in the Phoenix metropolitan area L. I. Kleinman,1

    E-Print Network [OSTI]

    Photochemical age determinations in the Phoenix metropolitan area L. I. Kleinman,1 P. H. Daum,1 Y oxidant field campaign conducted in the Phoenix air basin in the late spring of 1998. Sampling was done, Phoenix Citation: Kleinman, L. I., et al., Photochemical age determinations in the Phoenix metropolitan

  1. Debris flows from small catchments of the Ma Ha Tuak Range, metropolitan Phoenix, Arizona

    E-Print Network [OSTI]

    Dorn, Ron

    Debris flows from small catchments of the Ma Ha Tuak Range, metropolitan Phoenix, Arizona Ronald I from tiny but steep mountain catchments throughout metropolitan Phoenix, Arizona, USA. Urban growth downtown Phoenix, was selected to determine the feasibility of using the varnish microlaminations (VML

  2. Multiplex networks in metropolitan areas: generic features and local effects

    E-Print Network [OSTI]

    Strano, Emanuele; Dobson, Simon; Barthelemy, Marc

    2015-01-01

    Most large cities are spanned by more than one transportation system. These different modes of transport have usually been studied separately: it is however important to understand the impact on urban systems of the coupling between them and we report in this paper an empirical analysis of the coupling between the street network and the subway for the two large metropolitan areas of London and New York. We observe a similar behaviour for network quantities related to quickest paths suggesting the existence of generic mechanisms operating beyond the local peculiarities of the specific cities studied. An analysis of the betweenness centrality distribution shows that the introduction of underground networks operate as a decentralising force creating congestions in places located at the end of underground lines. Also, we find that increasing the speed of subways is not always beneficial and may lead to unwanted uneven spatial distributions of accessibility. In fact, for London -- but not for New York -- there is ...

  3. Efficient detection of contagious outbreaks in massive metropolitan encounter networks

    E-Print Network [OSTI]

    Sun, Lijun; Lee, Der-Horng; Cebrian, Manuel

    2014-01-01

    Physical contact remains difficult to trace in large metropolitan networks, though it is a key vehicle for the transmission of contagious outbreaks. Co-presence encounters during daily transit use provide us with a city-scale time-resolved physical contact network, consisting of 1 billion contacts among 3 million transit users. Here, we study the advantage that knowledge of such co-presence structures may provide for early detection of contagious outbreaks. We first examine the "friend sensor" scheme --- a simple, but universal strategy requiring only local information --- and demonstrate that it provides significant early detection of simulated outbreaks. Taking advantage of the full network structure, we then identify advanced "global sensor sets", obtaining substantial early warning times savings over the friends sensor scheme. Individuals with highest number of encounters are the most efficient sensors, with performance comparable to individuals with the highest travel frequency, exploratory behavior and ...

  4. Unequal development : decentralization and fiscal disparities in the Metropolitan Zone of the Valley of Mexico

    E-Print Network [OSTI]

    Raich, Uri

    2006-01-01

    This study is about the impact of decentralization in metropolitan areas. Studies of fiscal decentralization have largely centered on the formal tiers of government, without looking at the effects of this process on the ...

  5. Impact of primary formaldehyde on air pollution in the Mexico City Metropolitan Area

    E-Print Network [OSTI]

    Lei, Wenfang

    Formaldehyde (HCHO) is a radical source that plays an important role in urban atmospheric chemistry and ozone formation. The Mexico City Metropolitan Area (MCMA) is characterized by high anthropogenic emissions of HCHO ...

  6. Metropolitan governance and local land use planning in Boston, Denver, and Portland

    E-Print Network [OSTI]

    Rosan, Christina

    2007-01-01

    Metropolitan areas across the U.S. are characterized by sprawling development which uses larger amounts of open space than necessary, leads to the inefficient use of energy and water, increases social inequality, and causes ...

  7. Finite density phase transition of QCD with $N_f=4$ and $N_f=2$ using canonical ensemble method

    E-Print Network [OSTI]

    Anyi Li; Andrei Alexandru; Keh-Fei Liu; Xiangfei Meng

    2010-10-01

    In a progress toward searching for the QCD critical point, we study the finite density phase transition of $N_f = 4$ and 2 lattice QCD at finite temperature with the canonical ensemble approach. We develop a winding number expansion method to accurately project out the particle number from the fermion determinant which greatly extends the applicable range of baryon number sectors to make the study feasible. Our lattice simulation was carried out with the clover fermions and improved gauge action. For a given temperature, we calculate the baryon chemical potential from the canonical approach to look for the mixed phase as a signal for the first order phase transition. In the case of $N_f=4$, we observe an "S-shape" structure in the chemical potential-density plane due to the surface tension of the mixed phase in a finite volume which is a signal for the first order phase transition. We use the Maxwell construction to determine the phase boundaries for three temperatures below $T_c$. The intersecting point of the two extrapolated boundaries turns out to be at the expected first order transition point at $T_c$ with $\\mu = 0$. This serves as a check for our method of identifying the critical point. We also studied the $N_f =2$ case, but do not see a signal of the mixed phase for temperature as low as 0.83 $T_c$.

  8. Truck transport of RAM: Risk effects of avoiding metropolitan areas

    SciTech Connect (OSTI)

    Mills, G.S.; Neuhauser, K.S.

    1997-11-01

    In the transport of radioactive material (RAM), e.g., spent nuclear fuel (SNF), stakeholders are generally most concerned about risks in high population density areas along transportation routes because of the perceived high consequences of potential accidents. The most significant portions of a transcontinental route and an alternative examined previously were evaluated again using population density data derived from US Census Block data. This method of characterizing population that adjoins route segments offers improved resolution of population density variations, especially in high population density areas along typical transport routes. Calculated incident free doses and accident dose risks for these routes, and the rural, suburban and urban segments are presented for comparison of their relative magnitudes. The results indicate that modification of this route to avoid major metropolitan areas through use of non-Interstate highways increases total risk yet does not eliminate a relatively small urban component of the accident dose risk. This conclusion is not altered by improved resolution of route segments adjoining high density populations.

  9. Regional planning and operations architectures as means to foster transportation integration in the Mexico City Metropolitan Area

    E-Print Network [OSTI]

    Ortiz Mantilla, Bernardo Jose, 1977-

    2005-01-01

    The MCMA complexity in political, institutional, economical, and jurisdictional terms has resulted in limited coordination between MCMA authorities that in conjunction with the limited role of metropolitan transportation ...

  10. DraftApril 7, 2009 Features of Climate-Smart Metropolitan Economies

    E-Print Network [OSTI]

    emissions of carbon dioxide.) Residential and commercial buildings account for 39 percent of the carbon. To help provide benchmarks and expand our understanding of carbon emissions, this chapter quantifies highway transportation and residential carbon emissions of the 100 largest U.S. metropolitan areas in 2000

  11. DraftApril 7, 2009 Features of Climate-Smart Metropolitan Economies

    E-Print Network [OSTI]

    , such as coal and oil, for energy.3 (Here, the terms carbon emissions or carbon footprint both indicate of the economy, and (4) carbon intensity of the energy system.8 Shrinking the nation's carbon footprint, while solving environmental challenges. With supportive federal policies, metropolitan areas can provide the low-carbon

  12. Fuel-Based On-Road Motor Vehicle Emissions Inventory for the Denver Metropolitan Area

    E-Print Network [OSTI]

    Denver, University of

    Fuel-Based On-Road Motor Vehicle Emissions Inventory for the Denver Metropolitan Area Sajal S of obtaining on-road emissions inventories has been developed. This technique calculates emission factors these factors with fuel use data, available from tax records, yields a fuel based emission inventory. We have

  13. FARGO-MOORHEAD METROPOLITAN AREA, ND AND MN FLOOD RISK MANAGEMENT PROJECT

    E-Print Network [OSTI]

    US Army Corps of Engineers

    FARGO-MOORHEAD METROPOLITAN AREA, ND AND MN FLOOD RISK MANAGEMENT PROJECT 23 September 2011, and technically feasible flood risk management for Fargo, North Dakota, Moorhead, Minnesota, and the surrounding area, and a storage area to reduce the existing and future flood risk and damages to public and private

  14. Do Debris Flows Pose a Hazard to Mountain-Front Property in Metropolitan Phoenix, Arizona?

    E-Print Network [OSTI]

    Dorn, Ron

    Do Debris Flows Pose a Hazard to Mountain-Front Property in Metropolitan Phoenix, Arizona? Ronald I by growing suburbs of metropoli- tan Phoenix, Arizona, including on steep slopes above large single hazard in Phoenix and perhaps other grow- ing cities in the desert Southwest. Key Words: debris flow

  15. Response and Resistance to NF-?B Inhibitors in Mouse Models of Lung Adenocarcinoma

    E-Print Network [OSTI]

    Xue, Wen

    Lung adenocarcinoma is a leading cause of cancer death worldwide. We recently showed that genetic inhibition of the NF-?B pathway affects both the initiation and the maintenance of lung cancer, identifying this pathway as ...

  16. Requirement for NF-?B signalling in a mouse model of lung adenocarcinoma

    E-Print Network [OSTI]

    Meylan, Etienne

    NF-?B transcription factors function as crucial regulators of inflammatory and immune responses as well as of cell survival. They have also been implicated in cellular transformation and tumorigenesis. However, despite ...

  17. Interleukin-6 upregulates paraoxonase 1 gene expression via an AKT/NF-?B-dependent pathway

    SciTech Connect (OSTI)

    Cheng, Chi-Chih [Department of Research, Taichung Veterans General Hospital, Taichung, Taiwan (China)] [Department of Research, Taichung Veterans General Hospital, Taichung, Taiwan (China); Hsueh, Chi-Mei [Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan (China)] [Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan (China); Chen, Chiu-Yuan [Graduate Institute of Natural Healing Sciences, Nanhua University, Chiayi, Taiwan (China)] [Graduate Institute of Natural Healing Sciences, Nanhua University, Chiayi, Taiwan (China); Chen, Tzu-Hsiu, E-mail: hsiu@mail.chna.edu.tw [Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan (China)] [Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan (China); Hsu, Shih-Lan, E-mail: h2326@vghtc.gov.tw [Department of Research, Taichung Veterans General Hospital, Taichung, Taiwan (China) [Department of Research, Taichung Veterans General Hospital, Taichung, Taiwan (China); Department of Applied Chemistry, National Chi Nan University, Puli, Nantou, Taiwan (China)

    2013-07-19

    Highlights: •IL-6 could induce PON1 gene expression. •IL-6 increased NF-?B protein expression and NF-?B-p50 and -p65 subunits nuclear translocation. •IL-6-induced PON1 up-regulation was through an AKT/NF-?B pathway. -- Abstract: The aim of this study is to investigate the relationship between paraoxonase 1 (PON1) and atherosclerosis-related inflammation. In this study, human hepatoma HepG2 cell line was used as a hepatocyte model to examine the effects of the pro-inflammatory cytokines on PON1 expression. The results showed that IL-6, but not TNF-? and IL-1?, significantly increased both the function and protein level of PON1; data from real-time RT-PCR analysis revealed that the IL-6-induced PON1 expression occurred at the transcriptional level. Increase of I?B kinase activity and I?B phosphorylation, and reduction of I?B protein level were also observed in IL-6-treated HepG2 cells compared with untreated culture. This event was accompanied by increase of NF-?B-p50 and -p65 nuclear translocation. Moreover, treatment with IL-6 augmented the DNA binding activity of NF-?B. Furthermore, pharmacological inhibition of NF-?B activation by PDTC and BAY 11-7082, markedly suppressed the IL-6-mediated PON1 expression. In addition, IL-6 increased the levels of phosphorylated protein kinase B (PKB, AKT). An AKT inhibitor LY294002 effectively suppressed IKK/I?B/NF-?B signaling and PON1 gene expression induced by IL-6. Our findings demonstrate that IL-6 upregulates PON1 gene expression through an AKT/NF-?B signaling axis in human hepatocyte-derived HepG2 cell line.

  18. A test of first order scaling in Nf=2 QCD

    E-Print Network [OSTI]

    G. Cossu; M. D'Elia; A. Di Giacomo; C. Pica

    2007-09-30

    We complete our analysis of Nf=2 QCD based on the lattice staggered fermion formulation. Using a series of Monte Carlo simulations at fixed (amq*Ls^yh) one is able to test the universality class with given critical exponent yh. This strategy has been used to test the O(4) universality class and it has been presented at the previous Lattice conferences. No agreement was found with simulations in the mass range amq=[0.01335,0.15] using lattices with Ls=16 up to 32 and Lt=4. With the same strategy, we now investigate the possibility of a first order transition using a new set of Monte Carlo data corresponding to yh=3 in the same mass and volume range as the one used for O(4). A substantial agreement is observed both in the specific heat scaling and in the scaling of the chiral condensate, while the chiral susceptibilities still presents visible deviation from scaling in the mass range explored.

  19. The case for pension plan and university endowment equity investment in brownfields in the urban core of major metropolitan areas

    E-Print Network [OSTI]

    Larsen, Tamara C. (Tamara Candace), 1977-

    2003-01-01

    The purpose of this thesis is to present a case for institutional equity investment in brownfields in the urban core of major metropolitan areas. Pension plans and university endowments are the primary institutional investors ...

  20. In situ measurements of speciated atmospheric mercury and the identification of source regions in the Mexico City Metropolitan Area

    E-Print Network [OSTI]

    Rutter, A. P.

    In order to expand the currently limited understanding of atmospheric mercury source-receptor relationships in the Mexico City Metropolitan Area, real time measurements of atmospheric mercury were made at a downtown urban ...

  1. The effectiveness of jobs-housing balance as a strategy for reducing traffic congestion: a study of metropolitan Bangkok 

    E-Print Network [OSTI]

    Lobyaem, Sonchai

    2006-10-30

    Bangkok is widely known for its severe traffic congestion. The Thai government advocates the concept of jobs and housing balance (JHB) as a strategy for reducing traffic congestion in Metropolitan Bangkok. The basic idea is to decentralize the jobs...

  2. Chicago Metropolitan Agency for Planning Summary of Reported Data From July 1, 2010 - September 30, 2013

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum Based Fuels|Programs |Chart of breakout of fundsChicago Metropolitan Agency for

  3. Development of NF3 Deposit Removal Technology for the Portsmouth Gaseous Diffusion Plant

    SciTech Connect (OSTI)

    Scheele, R.D.; McNamara, B.K.; Rapko, B.M.; Edwards, M.K.; Kozelisky, A.E.; Daniel, R.C. [Battelle Pacific Northwest Division, PO Box 999, Battelle Blvd, Richland, Washington 99352 (United States); McSweeney, T.I.; Maharas, S.J.; Weaver, P.J.; Iwamasa, K.J. [Battelle Columbus Operations, 505 King Avenue, Columbus, Ohio 43201 (United States); Kefgen, R.B. [WASTREN, Inc., 1864 Shyville Road, Piketon, Ohio 45661 (United States)

    2006-07-01

    This paper summarizes the Battelle, Stoller, and WASTREN (BSW) team's efforts, to date, in support of the United States Department of Energy's plans to remove uranium and technetium deposits before decommissioning the Portsmouth Gaseous Diffusion Plant. The BSW team investigated nitrogen trifluoride (NF{sub 3}) as a safer yet effective alternative gaseous treatment to the chlorine trifluoride (ClF{sub 3})-elemental fluorine (F{sub 2}) treatment currently used to remove uranium and technetium deposits from the uranium enrichment cascade. Both ClF{sub 3} and F{sub 2} are highly reactive, toxic, and hazardous gases, while NF{sub 3}, although toxic [1], is no more harmful than moth balls [2]. BSW's laboratory thermo-analytical and laboratory-scale prototype studies with NF{sub 3} established that thermal NF{sub 3} can effectively remove likely and potential uranium (UO{sub 2}F{sub 2} and UF{sub 4}) and technetium deposits (a surrogate deposit material, TcO{sub 2}, and pertechnetates) by conversion to volatile compounds. Our engineering evaluations suggest that NF{sub 3}'s effectiveness could be enhanced by combining with a lesser concentration of ClF{sub 3}. BSW's and other's studies indicate compatibility with Portsmouth materials of construction (aluminum, copper, and nickel). (authors)

  4. Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells

    SciTech Connect (OSTI)

    Jian Li

    2012-11-07

    A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

  5. CARD6 Is a Modulator of NF-B Activation by Nod1-and Cardiak-mediated Pathways*

    E-Print Network [OSTI]

    CARD6 Is a Modulator of NF- B Activation by Nod1- and Cardiak-mediated Pathways* Received specific binding of this CARD6-encoding protein to Nod1 (CARD4), Cardiak (Rip2/Rick), NAC (NALP1/DEFCAP implicated in NF- B and caspase-1 activation but not to other CARD family proteins. Cardiak and Nod1 (but

  6. NF-?B1 Inhibits TLR-Induced IFN-? Production in Macrophages Through TPL-2-dependent ERK Activation

    E-Print Network [OSTI]

    Yang, Huei-Ting

    Although NF-?B1 p50/p105 has critical roles in immunity, the mechanism by which NF-?B1 regulates inflammatory responses is unclear. In this study, we analyzed the gene expression profile of LPS-stimulated Nfkb1?/? macrophages ...

  7. Investigating the role of intra- and extra-cellular modulators of the transcription factor NF-kappaB

    E-Print Network [OSTI]

    Nguyen, Hung Nhat

    2011-01-01

    The nuclear factor-kappa B (NF-kappaB) family of transcription factors play a pivotal role in the inflammatory and immune responses, as well as cell growth and survival. Since its discovery 25 years ago, NF-kappaB has ...

  8. 1 Managed by UT-Battelle for the U.S. Department of Energy NF Splash Mitigation 12 July 2011

    E-Print Network [OSTI]

    McDonald, Kirk

    1 Managed by UT-Battelle for the U.S. Department of Energy NF Splash Mitigation 12 July 2011 for comparison & final determination #12;3 Managed by UT-Battelle for the U.S. Department of Energy NF Splash Neutrino Factory Mercury Pool Splash Mitigation V.B. Graves IDS Videoconference July 12, 2011 #12;2 Managed

  9. VALIDATION OF EAF-2010 (N,G) AND (N,F) REACTIONS 1. INTEGRAL ACTIVATION DATA BASE FOR (N,G) AND (N,F) REACTIONS

    E-Print Network [OSTI]

    VALIDATION OF EAF-2010 (N,G) AND (N,F) REACTIONS 1. INTEGRAL ACTIVATION DATA BASE FOR (N,G) AND (N IRRAGIAMENTO SIC A FNG, supplied by M Pillon used at FNG for integral exps [175 group Vitamin-E weighting Pillon used at FNG for integral exps [175 group Vitamin-E weighting]. UKAEA-FUS-547 7 fng_tung.asc 175

  10. Instruction sheet for the consolidation of the standard NF EN 693 dated September 2001 and its amendment A1 Machine tools : Safety : Hydraulic presses

    E-Print Network [OSTI]

    Association Française de Normalisation. Paris

    2009-01-01

    Instruction sheet for the consolidation of the standard NF EN 693 dated September 2001 and its amendment A1

  11. Sanders, J. E.; and Merguerian, Charles, 1992a, Directional history of Pleistocene glaciers inferred from features eroded on bedrock, New York metropolitan area, SE NY.

    E-Print Network [OSTI]

    Merguerian, Charles

    inferred from features eroded on bedrock, New York metropolitan area, SE NY. If a glacier erodes bedrock Tryon Park, Central Park, and in the New York Botanical Garden. To Cite This Abstract: Sanders, J. E on bedrock, New York metropolitan area, SE NY (abs.): Geological Society of America, Abstracts with Programs

  12. Microstructural Evolution in Two Variants of NF709 at 1023 and 1073 K

    E-Print Network [OSTI]

    Cambridge, University of

    and that could invalidate the extrapolations of short-term creep test data, and to identify any precipitates.K.D.H. BHADESHIA The microstructural state of two grades of the creep-resistant austenitic stainless steels NF709 regarded as one of the best austenitic steels for elevated temperature applications because of its creep

  13. Purinergic signaling is required for fluid shear stress-induced NF-{kappa}B translocation in osteoblasts

    SciTech Connect (OSTI)

    Genetos, Damian C., E-mail: dgenetos@ucdavis.edu [Department of Anatomy, Cell Biology, and Physiology, School of Veterinary Medicine, University of California, Davis, CA (United States); Karin, Norman J. [Cell Biology and Biochemistry, Pacific Northwest National Laboratory, Richland, WA (United States)] [Cell Biology and Biochemistry, Pacific Northwest National Laboratory, Richland, WA (United States); Geist, Derik J. [Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN (United States)] [Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN (United States); Donahue, Henry J. [Division of Musculoskeletal Sciences, Department of Orthopaedics and Rehabilitation, Pennsylvania State College of Medicine, Hershey, PA (United States)] [Division of Musculoskeletal Sciences, Department of Orthopaedics and Rehabilitation, Pennsylvania State College of Medicine, Hershey, PA (United States); Duncan, Randall L. [Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN (United States)] [Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN (United States)

    2011-04-01

    Fluid shear stress regulates gene expression in osteoblasts, in part by activation of the transcription factor NF-{kappa}B. We examined whether this process was under the control of purinoceptor activation. MC3T3-E1 osteoblasts under static conditions expressed the NF-{kappa}B inhibitory protein I{kappa}B{alpha} and exhibited cytosolic localization of NF-{kappa}B. Under fluid shear stress, I{kappa}B{alpha} levels decreased, and concomitant nuclear localization of NF-{kappa}B was observed. Cells exposed to fluid shear stress in ATP-depleted medium exhibited no significant reduction in I{kappa}B{alpha}, and NF-{kappa}B remained within the cytosol. Similar results were found using oxidized ATP or Brilliant Blue G, P2X{sub 7} receptor antagonists, indicating that the P2X{sub 7} receptor is responsible for fluid shear-stress-induced I{kappa}B{alpha} degradation and nuclear accumulation of NF-{kappa}B. Pharmacologic blockage of the P2Y6 receptor also prevented shear-induced I{kappa}B{alpha} degradation. These phenomena involved neither ERK1/2 signaling nor autocrine activation by P2X{sub 7}-generated lysophosphatidic acid. Our results suggest that fluid shear stress regulates NF-{kappa}B activity through the P2Y{sub 6} and P2X{sub 7} receptor.

  14. MDI-QKD: Continuous- versus discrete-variables at metropolitan distances

    E-Print Network [OSTI]

    Stefano Pirandola; Carlo Ottaviani; Gaetana Spedalieri; Christian Weedbrook; Samuel L. Braunstein; Seth Lloyd; Tobias Gehring; Christian S. Jacobsen; Ulrik L. Andersen

    2015-08-01

    In a comment, Xu, Curty, Qi, Qian, and Lo claimed that discrete-variable (DV) measurement device independent (MDI) quantum key distribution (QKD) would compete with its continuous-variable (CV) counterpart at metropolitan distances. Actually, Xu et al.'s analysis supports exactly the opposite by showing that the experimental rate of our CV protocol (achieved with practical room-temperature devices) remains one order of magnitude higher than their purely-numerical and over-optimistic extrapolation for qubits, based on nearly-ideal parameters and cryogenic detectors (unsuitable solutions for a realistic metropolitan network, which is expected to run on cheap room-temperature devices, potentially even mobile). The experimental rate of our protocol (expressed as bits per relay use) is confirmed to be two-three orders of magnitude higher than the rate of any realistic simulation of practical DV-MDI-QKD over short-medium distances. Of course this does not mean that DV-MDI-QKD networks should not be investigated or built, but increasing their rate is a non-trivial practical problem clearly beyond the analysis of Xu et al. Finally, in order to clarify the facts, we also refute a series of incorrect arguments against CV-MDI-QKD and, more generally, CV-QKD, which were made by Xu et al. with the goal of supporting their thesis.

  15. Coal dust contiguity-induced changes in the concentration of TNF- and NF- B p65 on the ocular surface

    SciTech Connect (OSTI)

    Sun, Z.Y.; Hong, J.; Liu, Z.Y.; Jin, X.D.; Gu, C.H.

    2009-07-01

    To observe the influence of coal dust on ocular surface of coal miners and rabbits with coal dust contiguity on expression TNF- and NF- Bp65 and dry eye occurrence. Expression TNF- and NF- Bp65 in ocular surface were determined. Results showed tear production, BUT and lysozyme decreased for coal miners and rabbits with coal dust contiguity. Coal dust exposure was linked to development of xerophthalmia, and induced a higher expression of NF- B p65 and TNF- perhaps as a mechanism to resist coal dust ocular surface injury.

  16. Analysis and Comparison between War Driving and War Walk-ing in Metropolitan WiFi Radio Maps

    E-Print Network [OSTI]

    Chu, Hao-hua

    Analysis and Comparison between War Driving and War Walk- ing in Metropolitan WiFi Radio Maps Arvin, Hsinchu County, 310, Taiwan arvin@itri.org.tw ABSTRACT War-driving is currently the most widely adopted cost for war driv- ing is smaller than that of war walking, its positional accu- racy is also lower

  17. An Investigation into the Spatial Variability of Near-Surface Air Temperatures in the Detroit, Michigan, Metropolitan Region*

    E-Print Network [OSTI]

    Brown, Daniel G.

    An Investigation into the Spatial Variability of Near-Surface Air Temperatures in the Detroit. This study focused on the air temperatures in the Detroit, Michigan, metropolitan region during the summer portions of Detroit experienced decreased temperatures during afternoons. 1. Introduction In 2010, more

  18. Estimating overdispersion in the assessment of crime reduction interventions Paul R. Marchant, Leeds Metropolitan University, School of Information m

    E-Print Network [OSTI]

    Barber, Stuart

    , Leeds Metropolitan University, School of Information m Management, Leeds, LS6 3QS; email: p.marchant@leedsmet.ac.uk; phone: 0113 283 6109; fax: 0113 283 7599 Paul D. Baxter* and Stuart Barber, University of Leeds, Department of Statistics, Leeds LS2 9JT; email: pdbaxt@maths.leeds.ac.uk, stuart@maths.leeds.ac.uk; phone

  19. Natural Proteasome Inhibitor Celastrol Suppresses Androgen-Independent Prostate Cancer Progression by Modulating Apoptotic Proteins and NF-kappaB

    E-Print Network [OSTI]

    Dai, Yao; Jeffrey, Tang; Wenhua, Xiaojie; Meng, Yang; Burstein, Ezra; Lawrence, Theodore S.; Xu, Liang

    2010-12-10

    Background Celastrol is a natural proteasome inhibitor that exhibits promising anti-tumor effects in human malignancies, especially the androgen-independent prostate cancer (AIPC) with constitutive NF-?B activation. ...

  20. Linear noise approximation of noise-induced oscillation in NF-?B signaling network

    E-Print Network [OSTI]

    Jaewook Joo

    2010-10-08

    NF-{\\kappa}B, one of key regulators of inflammation, apoptosis, and differentiation, was found to have noisy oscillatory shuttling between the nucleus and the cytoplasm in single cells when cells are stimulated by cytokine TNF{\\alpha}. We present the analytical analysis which uncovers the underlying physical mechanisms of this spectacular noise-induced transition in biological networks. Starting with the master equation describing both signaling and transcription events in NF-{\\kappa}B signaling network, we derived the macroscopic and the Fokker-Planck equations by using van Kampen's sysem size expansion. Using the noise-induced oscillatory signatures present in the power spectrum, we constructed the two-dimensional phase diagram where the noise-induced oscillation emerges in the dynamically stable parameter space.

  1. Omentin inhibits TNF-{alpha}-induced expression of adhesion molecules in endothelial cells via ERK/NF-{kappa}B pathway

    SciTech Connect (OSTI)

    Zhong, Xia, E-mail: zhongxia1977@126.com [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)] [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China); Li, Xiaonan; Liu, Fuli; Tan, Hui [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)] [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China); Shang, Deya, E-mail: wenhuashenghuo1@163.com [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)] [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)

    2012-08-24

    Highlights: Black-Right-Pointing-Pointer Omentin inhibited TNF-{alpha}-induced adhesion of THP-1 cells to HUVECs. Black-Right-Pointing-Pointer Omentin reduces expression of ICAM-1 and VCAM-1 induced by TNF-{alpha} in HUVECs. Black-Right-Pointing-Pointer Omentin inhibits TNF-{alpha}-induced ERK and NF-{kappa}B activation in HUVECs. Black-Right-Pointing-Pointer Omentin supreeses TNF-{alpha}-induced expression of ICAM-1 and VCAM-1 via ERK/NF-{kappa}B pathway. -- Abstract: In the present study, we investigated whether omentin affected the expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in tumor necrosis factor-{alpha} (TNF-{alpha}) induced human umbilical vein endothelial cells (HUVECs). Our data showed that omentin decreased TNF-{alpha}-induced expression of ICAM-1 and VCAM-1 in HUVECs. In addition, omentin inhibited TNF-{alpha}-induced adhesion of THP-1 cells to HUVECs. Further, we found that omentin inhibited TNF-{alpha}-activated signal pathway of nuclear factor-{kappa}B (NF-{kappa}B) by preventing NF-{kappa}B inhibitory protein (I{kappa}B{alpha}) degradation and NF-{kappa}B/DNA binding activity. Omentin pretreatment significantly inhibited TNF-{alpha}-induced ERK activity and ERK phosphorylation in HUVECs. Pretreatment with PD98059 suppressed TNF-{alpha}-induced NF-{kappa}B activity. Omentin, NF-kB inhibitor (BAY11-7082) and ERK inhibitor (PD98059) reduced the up-regulation of ICAM-1 and VCAM-1 induced by TNF-{alpha}. These results suggest that omentin may inhibit TNF-{alpha}-induced expression of adhesion molecules in endothelial cells via blocking ERK/NF-{kappa}B pathway.

  2. Agreement Execution Process Study: CRADAs and NF-WFO Agreements and the Speed of Business

    SciTech Connect (OSTI)

    Harrer, Bruce J.; Cejka, Cheryl L.; Macklin, Richard; Miksovic, Ann

    2011-02-01

    This report summarizes the findings of a study on the execution of Cooperative Research and Development Agreements (CRADAs) and Non-Federal Work for Others (NF-WFO) agreements across the U.S. Department of Energy (DOE) laboratory complex. The study provides quantitiative estimates of times required to negotiate and execute these agreements across the DOE complex. It identifies factors impacting on cycle times and describes best practicies used at various laboratories and site offices that reduce cycle times.

  3. MC/NF TARGET SHIELDING STUDIES. NICHOLAS SOUCHLAS (10/29/2010)

    E-Print Network [OSTI]

    McDonald, Kirk

    MC/NF TARGET SHIELDING STUDIES. NICHOLAS SOUCHLAS (10/29/2010) 1 #12;Energy deposition from MARS, MARS+MCNP codes. STANDARD (STUDY II) GEOMETRY. STANDARD SHIELDING (80%WC+20% H2O). 4MW proton beamW to 50 kW in total power. 4 24 GeV 8 GeV #12;OFF/ON SHIELDING, DIFFERENT NEUTRON ENERGY CUTOFFS. 5 #12

  4. 1 Managed by UT-Battelle for the U.S. Department of Energy NF/IDS Hg Vessel Layout 30 Jun 09

    E-Print Network [OSTI]

    McDonald, Kirk

    1 Managed by UT-Battelle for the U.S. Department of Energy NF/IDS Hg Vessel Layout 30 Jun 09;3 Managed by UT-Battelle for the U.S. Department of Energy NF/IDS Hg Vessel Layout 30 Jun 09 Cross Section to flow out the front of the cryostat #12;4 Managed by UT-Battelle for the U.S. Department of Energy NF

  5. IDS-NF Impact of Neutrino Cross Section Impact of Neutrino Cross Section

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (JournalvivoHighHussein KhalilResearch &ENERGYWhoCELL WALLS4,IDRMSIDS-NF

  6. FY13 Summary Report on the Augmentation of the Spent Fuel Composition Dataset for Nuclear Forensics: SFCOMPO/NF

    SciTech Connect (OSTI)

    Brady Raap, Michaele C.; Lyons, Jennifer A.; Collins, Brian A.; Livingston, James V.

    2014-03-31

    This report documents the FY13 efforts to enhance a dataset of spent nuclear fuel isotopic composition data for use in developing intrinsic signatures for nuclear forensics. A review and collection of data from the open literature was performed in FY10. In FY11, the Spent Fuel COMPOsition (SFCOMPO) excel-based dataset for nuclear forensics (NF), SFCOMPO/NF was established and measured data for graphite production reactors, Boiling Water Reactors (BWRs) and Pressurized Water Reactors (PWRs) were added to the dataset and expanded to include a consistent set of data simulated by calculations. A test was performed to determine whether the SFCOMPO/NF dataset will be useful for the analysis and identification of reactor types from isotopic ratios observed in interdicted samples.

  7. ABD56 causes osteoclast apoptosis by inhibiting the NF{kappa}B and ERK pathways

    SciTech Connect (OSTI)

    Idris, Aymen [Rheumatic Diseases Unit, Molecular Medicine Centre, University of Edinburgh, General Western Hospital, Edinburgh, EH4 2XU (United Kingdom); Mrak, Emanuela [Bone Metabolic Unit, Scientific Institute H San Raffaele, via Olgettina 60, 20132 Milano (Italy); Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, via Vanvitelli 32, 20129 Milano (Italy); Greig, Iain [Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD (United Kingdom); Guidobono, Francesca [Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, via Vanvitelli 32, 20129 Milano (Italy); Ralston, Stuart H. [Rheumatic Diseases Unit, Molecular Medicine Centre, University of Edinburgh, General Western Hospital, Edinburgh, EH4 2XU (United Kingdom); Hof, Rob van 't [Rheumatic Diseases Unit, Molecular Medicine Centre, University of Edinburgh, General Western Hospital, Edinburgh, EH4 2XU (United Kingdom)], E-mail: rvanthof@staffmail.ed.ac.uk

    2008-06-20

    We have previously shown that the biphenylcarboxylic acid butanediol ester (ABD56) inhibits osteoclast formation and activity in vitro and in vivo. However, the mechanism of action of this compound is unknown. ABD56 inhibited osteoclast formation and caused osteoclast apoptosis, but had no effects on osteoblasts or macrophages. As the NF{kappa}B and MAPK pathways are essential for osteoclast formation and survival, we studied the effects of ABD56 on these pathways. ABD56 caused phosphorylation of p38, JNK and nuclear translocation of c-jun in osteoclasts. ABD56-induced apoptosis was prevented by the caspase inhibitor zVAD-fmk but was not prevented by the p38- or JNK-inhibitors. ABD56 completely abolished RANKL-induced I{kappa}B and ERK1/2 phosphorylation. Increasing the amount of RANKL partially rescued ABD56-induced apoptosis, indicating that the apoptosis is most probably due to the inhibition of survival signals such as ERK and NF{kappa}B, rather than activation of the p38 or Jnk MAPK pathways.

  8. (Draft) Community air pollution and mortality: Analysis of 1980 data from US metropolitan areas

    SciTech Connect (OSTI)

    Lipfert, F.W.

    1992-11-01

    1980 data from up to 149 metropolitan areas were used to define cross-sectional associations between community air pollution and ``excess`` human mortality. The regression model proposed by Ozkaynak and Thurston (1987), which accounted for age, race, education, poverty, and population density, was evaluated and several new models were developed. The new models also accounted for migration, drinking water hardness, and smoking, and included a more detailed description of race. Cause-of-death categories analyzed include all causes, all ``non-external`` causes, major cardiovascular diseases, and chronic obstructive pulmonary diseases (COPD). Both annual mortality rates and their logarithms were analyzed. Air quality data were obtained from the EPA AIRS database (TSP, SO{sub 4}{sup =}, Mn, and ozone) and from the inhalable particulate network (PM{sub 15}, PM{sub 2.5} and SO{sub 4}{sup =}, for 63{sup 4} locations). The data on particulates were averaged across all monitoring stations available for each SMSA and the TSP data were restricted to the year 1980. The associations between mortality and air pollution were found to be dependent on the socioeconomic factors included in the models, the specific locations included in the data set, and the type of statistical model used. Statistically significant associations were found as follows: between TSP and mortality due to non-external causes with log-linear models, but not with a linear model betweenestimated 10-year average (1980--90) ozone levels and 1980 non-external and cardiovascular deaths; and between TSP and COPD mortality for both linear and log-linear models. When the sulfate contribution to TSP was subtracted, the relationship with COPD mortality was strengthened.

  9. (Draft) Community air pollution and mortality: Analysis of 1980 data from US metropolitan areas

    SciTech Connect (OSTI)

    Lipfert, F.W.

    1992-11-01

    1980 data from up to 149 metropolitan areas were used to define cross-sectional associations between community air pollution and excess'' human mortality. The regression model proposed by Ozkaynak and Thurston (1987), which accounted for age, race, education, poverty, and population density, was evaluated and several new models were developed. The new models also accounted for migration, drinking water hardness, and smoking, and included a more detailed description of race. Cause-of-death categories analyzed include all causes, all non-external'' causes, major cardiovascular diseases, and chronic obstructive pulmonary diseases (COPD). Both annual mortality rates and their logarithms were analyzed. Air quality data were obtained from the EPA AIRS database (TSP, SO[sub 4][sup =], Mn, and ozone) and from the inhalable particulate network (PM[sub 15], PM[sub 2.5] and SO[sub 4][sup =], for 63[sup 4] locations). The data on particulates were averaged across all monitoring stations available for each SMSA and the TSP data were restricted to the year 1980. The associations between mortality and air pollution were found to be dependent on the socioeconomic factors included in the models, the specific locations included in the data set, and the type of statistical model used. Statistically significant associations were found as follows: between TSP and mortality due to non-external causes with log-linear models, but not with a linear model betweenestimated 10-year average (1980--90) ozone levels and 1980 non-external and cardiovascular deaths; and between TSP and COPD mortality for both linear and log-linear models. When the sulfate contribution to TSP was subtracted, the relationship with COPD mortality was strengthened.

  10. Journal of Membrane Science 256 (2005) 134142 Characterization of novel acid-stable NF membranes before and after

    E-Print Network [OSTI]

    Freger, Viatcheslav "Slava"

    2005-01-01

    to hot 20% sulfuric acid solutions for various times. Swelling and morphological changes measured Nanofiltration (NF) membranes represent a class of mem- branes with capabilities to selectively separate low- sulfone, which support an ultra-thin selective layer a few tens to a few hundred of nanometers thick

  11. Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-{kappa}B-mediated survival signaling

    SciTech Connect (OSTI)

    Leskinen, Markus J. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Heikkilae, Hanna M. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Speer, Mei Y. [Bioengineering Department, University of Washington, Seattle, WA 98195 (United States); Hakala, Jukka K. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Laine, Mika [Department of Medicine, Helsinki University Central Hospital and Minerva Institute for Medical Research, Helsinki (Finland); Kovanen, Petri T. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Lindstedt, Ken A. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland)]. E-mail: ken.lindstedt@wri.fi

    2006-05-01

    Chymase released from activated mast cells induces apoptosis of vascular smooth muscle cells (SMCs) in vitro by degrading the pericellular matrix component fibronectin, so causing disruption of focal adhesion complexes and Akt dephosphorylation, which are necessary for cell adhesion and survival. However, the molecular mechanisms of chymase-mediated apoptosis downstream of Akt have remained elusive. Here, we show by means of RT-PCR, Western blotting, EMSA, immunocytochemistry and confocal microscopy, that chymase induces SMC apoptosis by disrupting NF-{kappa}B-mediated survival signaling. Following chymase treatment, the translocation of active NF-{kappa}B/p65 to the nucleus was partly abolished and the amount of nuclear p65 was reduced. Pretreatment of SMCs with chymase also inhibited LPS- and IL-1{beta}-induced nuclear translocation of p65. The chymase-induced degradation of p65 was mediated by active caspases. Loss of NF-{kappa}B-mediated transactivation resulted in downregulation of bcl-2 mRNA and protein expression, leading to mitochondrial swelling and release of cytochrome c. The apoptotic process involved activation of both caspase 9 and caspase 8. The results reveal that, by disrupting the NF-{kappa}B-mediated survival-signaling pathway, activated chymase-secreting mast cells can mediate apoptosis of cultured arterial SMCs. Since activated mast cells colocalize with apoptotic SMCs in vulnerable areas of human atherosclerotic plaques, they may participate in the weakening and rupture of atherosclerotic plaques.

  12. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kB pathways

    E-Print Network [OSTI]

    Abecasis, Goncalo

    Genome-wide scan reveals association of psoriasis with IL-23 and NF-kB pathways Rajan P Nair1 Abecasis4,20, for the Collaborative Association Study of Psoriasis18 Psoriasis is a common immune-mediated disorder that affects the skin, nails and joints. To identify psoriasis susceptibility loci, we genotyped

  13. Modeling green fluorescent protein transcription, translation and modification as a method to obtain NF-kappaB activation profiles 

    E-Print Network [OSTI]

    Laible, Allyson Marie

    2009-05-15

    that fluorescence increases up to 24 hours after an initial delay of approximately four hours. The fluorescence data was also used to develop a model describing significant events leading to NF-?B activation and GFP expression. In addition, a model describing...

  14. Decreasing NF-?B Expression Enhances Odontoblastic Differentiation and Collagen Expression in Dental Pulp Stem Cells Exposed to Inflammatory Cytokines 

    E-Print Network [OSTI]

    Hozhabri, Neda S. T.; Benson, M. Douglas; Vu, Michael D.; Patel, Rinkesh H.; Martinez, Rebecca M.; Nakhaie, Fatemeh N.; Kim, Harry K. W.; Varanasi, Venu G.

    2015-01-28

    Decreasing NF-?B Expression Enhances Odontoblastic Differentiation and Collagen Expression in Dental Pulp Stem Cells Exposed to Inflammatory Cytokines Neda S. T. Hozhabri1, M. Douglas Benson1, Michael D. Vu1, Rinkesh H. Patel1, Rebecca M. Martinez1, Fatemeh N...

  15. Ascorbic acid suppresses endotoxemia and NF-?B signaling cascade in alcoholic liver fibrosis in guinea pigs: A mechanistic approach

    SciTech Connect (OSTI)

    Abhilash, P.A.; Harikrishnan, R.; Indira, M.

    2014-01-15

    Alcohol consumption increases the small intestinal bacterial overgrowth (SIBO) and intestinal permeability of endotoxin. The endotoxin mediated inflammatory signaling plays a major role in alcoholic liver fibrosis. We evaluated the effect of ascorbic acid (AA), silymarin and alcohol abstention on the alcohol induced endotoxemia and NF-?B activation cascade pathway in guinea pigs (Cavia porcellus). Guinea pigs were administered ethanol at a daily dose of 4 g/kg b.wt for 90 days. After 90 days, ethanol administration was stopped. The ethanol treated animals were divided into abstention, silymarin (250 mg/kg b.wt) and AA (250 mg/kg b.wt) supplemented groups and maintained for 30 days. The SIBO, intestinal permeability and endotoxin were significantly increased in the ethanol group. The mRNA expressions of intestinal proteins claudin, occludin and zona occludens-1 were significantly decreased in ethanol group. The mRNA levels of inflammatory receptors, activity of IKK? and the protein expressions of phospho-I?B?, NF-?B, TNF-?, TGF-?{sub 1} and IL-6 were also altered in ethanol group. The expressions of fibrosis markers ?-SMA, ?{sub 1} (I) collagen and sirius red staining in the liver revealed the induction of fibrosis. But the supplementation of AA could induce greater reduction of ethanol induced SIBO, intestinal barrier defects, NF-?B activation and liver fibrosis than silymarin. The possible mechanism may be the inhibitory effect of AA on SIBO, intestinal barrier defect and IKK?, which decreased the activation of NF-?B and synthesis of cytokines. This might have led to suppression of HSCs activation and liver fibrosis. - Highlights: • Alcohol increases intestinal bacterial overgrowth and permeability of endotoxin. • Endotoxin mediated inflammation plays a major role in alcoholic liver fibrosis. • Ascorbic acid reduces endotoxemia, NF-?B activation and proinflammatory cytokines. • AA's action is by inhibition of SIBO, IKK? and alteration of intestinal permeability. • This might have led to suppression of HSCs activation and liver fibrosis.

  16. Chemical evolution of volatile organic compounds in the outflow of the Mexico City Metropolitan area

    SciTech Connect (OSTI)

    Apel, Eric; Emmons, L.; Karl, Thomas G.; Flocke, Frank M.; Hills, A. J.; Madronich, Sasha; Lee-Taylor, J.; Fried, Alan; Weibring, P.; Walega, J.; Richter, Dirk; Tie, X.; Mauldin, L.; Campos, Teresa; Weinheimer, Andrew J.; Knapp, David; Sive, B.; Kleinman, Lawrence I.; Springston, S.; Zaveri, Rahul A.; Ortega, John V.; Voss, Paul B.; Blake, D. R.; Baker, Angela K.; Warneke, Carsten; Welsh-Bon, Daniel; de Gouw, Joost A.; Zheng, J.; Zhang, Renyi; Rudolph, Jochen; Junkermann, W.; Riemer, D.

    2010-01-01

    The volatile organic compound (VOC) distribution in the Mexico City Metropolitan Area (MCMA) and its evolution as it is uplifted and transported out of the MCMA basin was studied during the 2006 MILAGRO/MIRAGE-Mex field campaign. The results show that in the morning hours in the city center, the VOC distribution is dominated by non-methane hydrocarbons (NMHCs) but with a substantial contribution from oxygenated volatile organic compounds (OVOCs), predominantly from primary emissions. Alkanes account for a large part of the NMHC distribution in terms of mixing ratios. In terms of reactivity, NMHCs also dominate overall, especially in the morning hours. However, in the afternoon, as the boundary layer lifts and air is mixed and aged within the basin, the distribution changes as secondary products are formed. The WRF-Chem (Weather Research and Forecasting with Chemistry) model and MOZART (Model for Ozone and Related chemical Tracers) were able to reproduce the general features of the daytime cycle of the VOC OH reactivity distribution showing that NMHCs dominate the distribution except in the afternoon hours and that the VOC OH reactivity peaks in the early morning due to high morning emissions from the city into a shallow boundary layer. The WRF-Chem and MOZART models showed higher reactivity than the experimental data during the nighttime cycle, perhaps indicating problems with the modeled nighttime boundary layer height. In addition, a plume was studied in which air was advected out of the MCMA and intercepted downwind with the DOE G1 on March 18 and the NCAR C130 one day later on March 19. A number of identical species measured aboard each aircraft gave insight into the chemical evolution of the plume as it aged and was transported as far as 1000 km downwind. Ozone and many OVOCs were photochemically produced in the plume. The WRF-Chem and MOZART models were used to examine the spatial and temporal extent of the March 19 plume and to help interpret the OH reactivity in the downwind plume. The model results generally showed good agreement with experimental results for the total VOC OH reactivity downwind and gave insight into the distributions of VOC chemical classes downwind. A box model with detailed gas phase chemistry (NCAR Master Mechanism), initialized with concentrations observed at one of the ground sites in the MCMA, was used to examine the expected evolution of specific VOCs over a 1-2 day period. The models clearly supported the experimental evidence for NMHC oxidation leading to the formation of OVOCs downwind, which then become the primary fuel for ozone production far away from the MCMA.

  17. Chemical evolution of volatile organic compounds in the outflow of the Mexico City Metropolitan area

    SciTech Connect (OSTI)

    Apel, E.; Springston, S.; Karl, T.; Emmons, L.; Flocke, F.; Hills, A. J.; Madronich, S.; Lee-Taylor, J.; Fried, A.; Weibring, P.; Walega, J.; Richter, D., Tie, X.; Mauldin, L.; Campos, T.; Sive, B.; Kleinman, L.; Springston, S., Zaveri, R.; deGouw, J.; Zheng, J.; Zhang, R.; Rudolph, J.; Junkermann, W.; Riemer, D. D.

    2009-11-01

    The volatile organic compound (VOC) distribution in the Mexico City Metropolitan Area (MCMA) and its evolution as it is uplifted and transported out of the MCMA basin was studied during the 2006 MILAGRO/MIRAGE-Mex field campaign. The results show that in the morning hours in the city center, the VOC distribution is dominated by non-methane hydrocarbons (NMHCs) but with a substantial contribution from oxygenated volatile organic compounds (OVOCs), predominantly from primary emissions. Alkanes account for a large part of the NMHC distribution in terms of mixing ratios. In terms of reactivity, NMHCs also dominate overall, especially in the morning hours. However, in the afternoon, as the boundary layer lifts and air is mixed and aged within the basin, the distribution changes as secondary products are formed. The WRF-Chem (Weather Research and Forecasting with Chemistry) model and MOZART (Model for Ozone and Related chemical Tracers) were able to reproduce the general features of the daytime cycle of the VOC OH reactivity distribution showing that NMHCs dominate the distribution except in the afternoon hours and that the VOC OH reactivity peaks in the early morning due to high morning emissions from the city into a shallow boundary layer. The WRF-Chem and MOZART models showed higher reactivity than the experimental data during the nighttime cycle, perhaps indicating problems with the modeled nighttime boundary layer height. In addition, a plume was studied in which air was advected out of the MCMA and intercepted downwind with the DOE G1 on 18 March and the NCAR C130 one day later on 19 March. A number of identical species measured aboard each aircraft gave insight into the chemical evolution of the plume as it aged and was transported as far as 1000 km downwind. Ozone and many OVOCs were photochemically produced in the plume. The WRF-Chem and MOZART models were used to examine the spatial and temporal extent of the 19 March plume and to help interpret the OH reactivity in the downwind plume. The model results generally showed good agreement with experimental results for the total VOC OH reactivity downwind and gave insight into the distributions of VOC chemical classes downwind. A box model with detailed gas phase chemistry (NCAR Master Mechanism), initialized with concentrations observed at one of the ground sites in the MCMA, was used to examine the expected evolution of specific VOCs over a 1-2 day period. The models clearly supported the experimental evidence for NMHC oxidation leading to the formation of OVOCs downwind, which then become the primary fuel for ozone production far away from the MCMA.

  18. Bulletin of the Seismological Society of America, Vol. 94, No. 6, pp. 21372163, December 2004 A Probabilistic Approach to Seismic Hazard in Metropolitan France

    E-Print Network [OSTI]

    Avouac, Jean-Philippe

    methods to seismic hazard assessment in France. This study differs from previous studies that have adopted A Probabilistic Approach to Seismic Hazard in Metropolitan France by Sylvie Marin, Jean-Philippe Avouac,* Marc Nicolas, and Antoine Schlupp Abstract In this study, we applied a probabilistic methodology to seismic

  19. Effects of urban land cover modifications in a mesoscale meteorological model on surface temperature and heat fluxes in the Phoenix metropolitan area.

    E-Print Network [OSTI]

    Hall, Sharon J.

    Effects of urban land cover modifications in a mesoscale meteorological model on surface between the two simulations. Mesoscale atmospheric models such as the Pennsylvania State University for the Phoenix metropolitan area was implemented in the fifth- generation PSU/NCAR mesoscale meteorological model

  20. Mathematical Modeling of Hepatitis C Prevalence Reduction with Antiviral Treatment Scale-Up in Persons Who Inject Drugs in Metropolitan Chicago

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Echevarria, Desarae; Gutfraind, Alexander; Boodram, Basmattee; Major, Marian; Del Valle, Sara; Cotler, Scott J.; Dahari, Harel

    2015-08-21

    New direct-acting antivirals (DAAs) provide an opportunity to combat hepatitis C virus (HCV) infection in persons who inject drugs (PWID). Here we use a mathematical model to predict the impact of a DAA-treatment scale-up on HCV prevalence among PWID and the estimated cost in metropolitan Chicago.

  1. East Coast Cool-Weather Storms in the New York Metropolitan Region Hunter College of the City University of New York, New York, New York

    E-Print Network [OSTI]

    Salmun, Haydee

    East Coast Cool-Weather Storms in the New York Metropolitan Region H. SALMUN Hunter College of the City University of New York, New York, New York A. MOLOD University of Maryland, Baltimore County of New York, New York, New York (Manuscript received 20 January 2009, in final form 3 May 2009) ABSTRACT

  2. Thermal Reactions of Uranium Metal, UO2, U3O8, UF4, and UO2F2 with NF3 to Produce UF6

    SciTech Connect (OSTI)

    McNamara, Bruce K.; Scheele, Randall D.; Kozelisky, Anne E.; Edwards, Matthew K.

    2009-11-01

    he objective of this paper is to demonstrate that NF3 fluorinates uranium metal, UO2, UF4, UO3, U3O8, and UO2F2•2H2O to produce the volatile UF6 at temperatures between 100 and 500?C. Thermogravimetric reaction profiles are described that reflect changes in the uranium oxidation state and discrete chemical speciation. Differences in the onset temperatures for each system indicate that NF3-substrate interactions are important for the temperature at which NF3 reacts: U metal > UO3 > UO2 > UO2F2 > UF4 and in fact may indicate different fluorination mechanisms for these various substrates. These studies demonstrate that NF3 is a potential replacement fluorinating agent in the existing nuclear fuel cycle and in oft-proposed actinide volatility reprocessing.

  3. TCR and CD28 activate the transcription factor NF- B in T-cells viadistinct adaptor signaling complexes

    E-Print Network [OSTI]

    Thaker, Youg Raj; Schneider, Helga; Rudd, Christopher E.

    2014-10-23

    Article history: Received 19 A Received in re Accepted 15 O Available onlin Keywords: Adaptors ADAP VAV-1 GRB-2 NF-?B ed fo nd CD ng T- n wit ?B in F-?B p?/? m Over-expression of ADAP or its binding partner SKAP1 failed to enhance anti-CD28... to CD28 addition, Tu can deliver complexes co-operate Rac-1 and m Despite ponents of T-cells have various kno 170F) mice that the TC the NF-?B p that the CD ent signalin 2. Materia 2.1. Mice an DO11.10 (kindly pro School of M Dr. Erik Pe housed und...

  4. Nmero Nome 1T 2T R1T R2T E AC NF 42200 Armando Dias

    E-Print Network [OSTI]

    Baia, Margarida

    Sheet1 Page 1 Número Nome 1T 2T R1T R2T E AC NF 42200 Armando Dias 53515 Jorge Branco 55774 João 70100 Catarina Ferreira 70146 Mariana Castro 70364 Nuno Gaspar 70524 António Grego 10 2 5 70934 João.2 2 15 78167 Afonso Sarmento 13.8 8.3 7.6 2 12 78175 Carlos Martins 14.3 12.6 11 2 14 78183 Ana

  5. Comparison of Daytime and Nighttime Populations Adjacent to Interstate Highways in Metropolitan Areas Using LandScan USA

    SciTech Connect (OSTI)

    Johnson, Paul E [ORNL] [ORNL

    2007-01-01

    An article of similar title was published in the International Journal of Radioactive Materials Transport in 1999. The study concluded that the daytime and nighttime populations are not substantially different for the metropolitan areas examined. This study revisits the issue, but using the LandScan USA high resolution population distribution data, which includes daytime and night-time population. Segments of Interstate highway beltways, along with the direct route through the city, for Atlanta, St. Louis, and Kansas City are examined with an 800m buffer from either side of the highways. The day/night ratio of population is higher using the LandScan USA data. LandScan USA daytime and night-time data will be incorporated into the TRAGIS routing model in future.

  6. Etching of UO{sub 2} in NF{sub 3} RF Plasma Glow Discharge

    SciTech Connect (OSTI)

    John M. Veilleux

    1999-08-01

    A series of room temperature, low pressure (10.8 to 40 Pa), low power (25 to 210 W) RF plasma glow discharge experiments with UO{sub 2} were conducted to demonstrate that plasma treatment is a viable method for decontaminating UO{sub 2} from stainless steel substrates. Experiments were conducted using NF{sub 3} gas to decontaminate depleted uranium dioxide from stainless-steel substrates. Depleted UO{sub 2} samples each containing 129.4 Bq were prepared from 100 microliter solutions of uranyl nitrate hexahydrate solution. The amorphous UO{sub 2} in the samples had a relatively low density of 4.8 gm/cm{sub 3}. Counting of the depleted UO{sub 2} on the substrate following plasma immersion was performed using liquid scintillation counting with alpha/beta discrimination due to the presence of confounding beta emitting daughter products, {sup 234}Th and {sup 234}Pa. The alpha emission peak from each sample was integrated using a gaussian and first order polynomial fit to improve quantification. The uncertainties in the experimental measurement of the etched material were estimated at about {+-} 2%. Results demonstrated that UO{sub 2} can be completely removed from stainless-steel substrates after several minutes processing at under 200 W. At 180 W and 32.7 Pa gas pressure, over 99% of all UO{sub 2} in the samples was removed in just 17 minutes. The initial etch rate in the experiments ranged from 0.2 to 7.4 {micro}m/min. Etching increased with the plasma absorbed power and feed gas pressure in the range of 10.8 to 40 Pa. A different pressure effect on UO{sub 2} etching was also noted below 50 W in which etching increased up to a maximum pressure, {approximately}23 Pa, then decreased with further increases in pressure.

  7. A (P)HMC algorithm for N_f = 2 + 1 + 1 flavours of twisted mass fermions

    E-Print Network [OSTI]

    T. Chiarappa; R. Frezzotti; C. Urbach

    2005-09-27

    We present a detailed design of a (P)HMC simulation algorithm for N_f = 2 + 1 + 1 maximally twisted Wilson quark flavours. The algorithm retains even/odd and mass-shift preconditionings combined with multiple Molecular Dynamics time scales for both the light mass degenerate, u and d, quarks and the heavy mass non-degenerate, s and c, quarks. Various non-standard aspects of the algorithm are discussed, among which those connected to the use of a polynomial approximation for the inverse (square root of the squared) Dirac matrix in the s and c quark sector.

  8. Hadron-Hadron Interactions from $N_f=2+1+1$ Lattice QCD: isospin-2 $??$ scattering length

    E-Print Network [OSTI]

    C. Helmes; C. Jost; B. Knippschild; C. Liu; J. Liu; L. Liu; C. Urbach; M. Ueding; Z. Wang; M. Werner

    2015-06-01

    We present results for the $I=2$ $\\pi\\pi$ scattering length using $N_f=2+1+1$ twisted mass lattice QCD for three values of the lattice spacing and a range of pion mass values. Due to the use of Laplacian Heaviside smearing our statistical errors are reduced compared to previous lattice studies. A detailed investigation of systematic effects such as discretisation effects, volume effects, and pollution of excited and thermal states is performed. After extrapolation to the physical point using chiral perturbation theory at NLO we obtain $M_\\pi a_0=-0.0442(2)_\\mathrm{stat}(^{+4}_{-0})_\\mathrm{sys}$.

  9. Determination of c_sw in N_f=3+1 Lattice QCD with massive Wilson fermions

    E-Print Network [OSTI]

    Patrick Fritzsch; Rainer Sommer; Felix Stollenwerk; Ulli Wolff

    2015-01-27

    We develop a strategy for the non-perturbative determination of the O(a)-improvement coefficient c_sw for Wilson fermions with massive sea quarks. The improvement condition is defined via the PCAC relation in the Schr\\"odinger functional. It is imposed along a line of constant physics designed to be close to the correct mass of the charm quark. The numerical work uses the tree-level improved L\\"uscher-Weisz gauge action in N_f=3+1 Lattice QCD.

  10. Angiotensin II modulates interleukin-1{beta}-induced inflammatory gene expression in vascular smooth muscle cells via interfering with ERK-NF-{kappa}B crosstalk

    SciTech Connect (OSTI)

    Xu, Shanqin [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States)] [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States); Zhi, Hui [Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States)] [Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States); Hou, Xiuyun [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States)] [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States); Jiang, Bingbing, E-mail: bjiang1@rics.bwh.harvard.edu [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States) [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States)

    2011-07-08

    Highlights: {yields} We examine how angiotensin II modulates ERK-NF-{kappa}B crosstalk and gene expression. {yields} Angiotensin II suppresses IL-1{beta}-induced prolonged ERK and NF-{kappa}B activation. {yields} ERK-RSK1 signaling is required for IL-1{beta}-induced prolonged NF-{kappa}B activation. {yields} Angiotensin II modulates NF-{kappa}B responsive genes via regulating ERK-NF-{kappa}B crosstalk. {yields} ERK-NF-{kappa}B crosstalk is a novel mechanism regulating inflammatory gene expression. -- Abstract: Angiotensin II is implicated in cardiovascular diseases, which is associated with a role in increasing vascular inflammation. The present study investigated how angiotensin II modulates vascular inflammatory signaling and expression of inducible nitric oxide synthase (iNOS) and vascular cell adhesion molecule (VCAM)-1. In cultured rat aortic vascular smooth muscle cells (VSMCs), angiotensin II suppressed interleukin-1{beta}-induced prolonged phosphorylation of extracellular signal-regulated kinase (ERK) and ribosomal S6 kinase (RSK)-1, and nuclear translocation of nuclear factor (NF)-{kappa}B, leading to decreased iNOS but enhanced VCAM-1 expression, associated with an up-regulation of mitogen-activated protein kinase phosphatase-1 expression. Knock-down of RSK1 selectively down regulated interleukin-1{beta}-induced iNOS expression without influencing VCAM-1 expression. In vivo experiments showed that interleukin-1{beta}, iNOS, and VCAM-1 expression were detectable in the aortic arches of both wild-type and apolipoprotein E-deficient (ApoE{sup -/-}) mice. VCAM-1 and iNOS expression were higher in ApoE{sup -/-} than in wild type mouse aortic arches. Angiotensin II infusion (3.2 mg/kg/day, for 6 days, via subcutaneous osmotic pump) in ApoE{sup -/-} mice enhanced endothelial and adventitial VCAM-1 and iNOS expression, but reduced medial smooth muscle iNOS expression associated with reduced phosphorylation of ERK and RSK-1. These results indicate that angiotensin II can differentially modulate inflammatory gene expression in aortic smooth muscle cells through influencing ERK-NF-{kappa}B crosstalk, which may contribute to angiotensin II-induced inflammatory disorders related to cardiovascular diseases.

  11. Apolipoprotein E inhibits osteoclast differentiation via regulation of c-Fos, NFATc1 and NF-?B

    SciTech Connect (OSTI)

    Kim, Woo-Shin; Kim, Hyung Joon; Lee, Zang Hee [Department of Cell and Developmental Biology, BK21 Program and Dental Research Institute, Seoul National University, 28 Yeongon-Dong, Chongno-Gu, Seoul 110-749 (Korea, Republic of); Lee, Youngkyun [Department of Biochemistry, School of Dentistry, Kyungpook National University, Daegu 700-422 (Korea, Republic of); Kim, Hong-Hee, E-mail: hhbkim@snu.ac.kr [Department of Cell and Developmental Biology, BK21 Program and Dental Research Institute, Seoul National University, 28 Yeongon-Dong, Chongno-Gu, Seoul 110-749 (Korea, Republic of)

    2013-02-15

    Apolipoprotein E (ApoE) plays a major role in the transport and metabolism of lipid. Other functions of ApoE include modulation of innate and adaptive immune responses. The expression of ApoE in osteoblasts and its relevance with bone formation have also been reported. However, the effect of ApoE on osteoclasts has not yet been examined. Here, we investigated the role of ApoE in osteoclast differentiation using bone marrow-derived macrophages (BMMs) and RAW264.7 cells. We found a down-regulation of ApoE gene expression during osteoclastic differentiation of those cells. Overexpression of ApoE in BMMs and RAW264.7 cells significantly blocked the induction of c-Fos and nuclear factor of activated T cell c1 (NFATc1), transcription factors critical for expression of osteoclast marker genes, by receptor activator of nuclear factor ?B ligand (RANKL), the osteoclast differentiation factor. ApoE inhibited osteoclast differentiation, as measured by decreased number of tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cells (MNCs). In addition, ApoE reduced the expression of dendritic cell-specific transmembrane protein (DC-STAMP) and ATPase, H{sup +} transporting, lysosomal 38 kDa, V0 subunit d2 (ATP6v0d2), genes involved in cell–cell fusion during osteoclastogenesis. Knock-down of ApoE using a specific siRNA promoted the RANKL-mediated induction of osteoclast differentiation. While ApoE did not affect the activation of ERK, JNK, and p38 MAPK signaling pathways by RANKL, the phosphorylation of p65 trans-activation domain on serine 536 and transcription activity of NF-?B were reduced by ApoE overexpression. These findings suggest that ApoE plays an inhibitory role in osteoclast differentiation via the suppression of RANKL-dependent activation of NF-?B and induction of c-Fos and NFATc1. - Highlights: ? Apolipoprotein E (ApoE) significantly inhibited osteoclast differentiation and activation of NF-?B. ? ApoE decreased the induction of osteoclast marker genes such as c-Fos, NFATc1, TRAP, DC-STAMP and Cathepsin K. ? ApoE reduced number of TRAP-positive multinuclear cells. ? Exogenous ApoE inhibits osteoclast formation by reduction of crucial factor of osteoclast differentiation. ? knock-down of ApoE promoted the RANKL-mediated induction of osteoclast differentiation.

  12. Differential Effects of ?-catenin and NF-?B Interplay in the Regulation of Cell Proliferation, Inflammation and Tumorigenesis in Response to Bacterial Infection

    E-Print Network [OSTI]

    Chandrakesan, Parthasarathy; Jakkula, Laxmi Uma Maheswar Rao; Ahmed, Ishfaq; Roy, Badal; Anant, Shrikant; Umar, Shahid

    2013-11-21

    Both ?-catenin and NF-?B have been implicated in our laboratory as candidate factors in driving proliferation in an in vivo model of Citrobacter rodentium (CR)-induced colonic crypt hyper-proliferation and hyperplasia. Herein, we test the hypothesis...

  13. GRP94/gp96 Elicits ERK Activation in Murine Macrophages A ROLE FOR ENDOTOXIN CONTAMINATION IN NF-B ACTIVATION AND NITRIC OXIDE PRODUCTION*

    E-Print Network [OSTI]

    Nicchitta, Chris

    GRP94/gp96 Elicits ERK Activation in Murine Macrophages A ROLE FOR ENDOTOXIN CONTAMINATION IN NF- B signaling and ni- tric oxide production, as well as the MAP kinase p38, JNK, and ERK signaling cascades a marked increase in ERK phosphorylation at protein concentrations as low as 2 g/ml. These results

  14. Community air pollution and mortality: Analysis of 1980 data from US metropolitan areas. 1: Particulate air pollution

    SciTech Connect (OSTI)

    Lipfert, F.W.

    1992-11-01

    1980 data from up to 149 metropolitan areas were used to define cross-sectional associations between community air pollution and excess human mortality. The regression model proposed by Oezkaynak and Thurston, which accounted for age, race, education, poverty, and population density, was evaluated and several new models were developed. The new models also accounted for population change, drinking water hardness, and smoking, and included a more detailed description of race. Cause-of-death categories analyzed include all causes, all non-external causes, major cardiovascular diseases, and chronic obstructive pulmonary diseases (COPD). Both annual mortality rates and their logarithms were analyzed. The data on particulates were averaged across all monitoring stations available for each SMSA and the TSP data were restricted to the year 1980. The associations between mortality and air pollution were found to be dependent on the socioeconomic factors included in the models, the specific locations included din the data set, and the type of statistical model used. Statistically significant associations were found between TSP and mortality due to non-external causes with log-linear models, but not with a linear model, and between TS and COPD mortality for both linear and log-linear models. When the sulfate contribution to TSP was subtracted, the relationship with COPD mortality was strengthened. Scatter plots and quintile analyses suggested a TSP threshold for COPD mortality at around 65 ug/m{sup 3} (annual average). SO{sub 4}{sup {minus}2}, Mn, PM{sup 15}, and PM{sub 2.5} were not significantly associated with mortality using the new models.

  15. Osthole inhibits the invasive ability of human lung adenocarcinoma cells via suppression of NF-?B-mediated matrix metalloproteinase-9 expression

    SciTech Connect (OSTI)

    Kao, Shang-Jyh [Department of Chest Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China) [Department of Chest Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan (China); School of Respiratory Therapy, Taipei Medical University, Taipei Taiwan (China); Su, Jen-Liang [Graduate Institute of Cancer Biology, College of Medicine, China Medical University, Taichung, Taiwan (China) [Graduate Institute of Cancer Biology, College of Medicine, China Medical University, Taichung, Taiwan (China); Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan (China); Department of Biotechnology, Asia University, Taichung, Taiwan (China); Chen, Chi-Kuan [Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan (China)] [Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan (China); Yu, Ming-Chih; Bai, Kuan-Jen; Chang, Jer-Hua [Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan (China)] [Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan (China); Bien, Mauo-Ying [School of Respiratory Therapy, Taipei Medical University, Taipei Taiwan (China) [School of Respiratory Therapy, Taipei Medical University, Taipei Taiwan (China); Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan (China); Yang, Shun-Fa [Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan (China) [Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan (China); Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan (China); Chien, Ming-Hsien, E-mail: mhchien1976@gmail.com [Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan (China)] [Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan (China)

    2012-05-15

    The induction of matrix metalloproteinase (MMP)-9 is particularly important for the invasiveness of various cancer cells. Osthole, a natural coumarin derivative extracted from traditional Chinese medicines, is known to inhibit the proliferation of a variety of tumor cells, but the effect of osthole on the invasiveness of tumor cells is largely unknown. This study determines whether and by what mechanism osthole inhibits invasion in CL1-5 human lung adenocarcinoma cells. Herein, we found that osthole effectively inhibited the migratory and invasive abilities of CL1-5 cells. A zymographic assay showed that osthole inhibited the proteolytic activity of MMP-9 in CL1-5 cells. Inhibition of migration, invasion, and MMP2 and/or MMP-9 proteolytic activities was also observed in other lung adenocarcinoma cell lines (H1299 and A549). We further found that osthole inhibited MMP-9 expression at the messenger RNA and protein levels. Moreover, a chromatin immunoprecipitation assay showed that osthole inhibited the transcriptional activity of MMP-9 by suppressing the DNA binding activity of nuclear factor (NF)-?B in the MMP-9 promoter. Using reporter assays with point-mutated promoter constructs further confirmed that the inhibitory effect of osthole requires an NF-?B binding site on the MMP-9 promoter. Western blot and immunofluorescence assays demonstrated that osthole inhibited NF-?B activity by inhibiting I?B-? degradation and NF-?B p65 nuclear translocation. In conclusion, we demonstrated that osthole inhibits NF-?B-mediated MMP-9 expression, resulting in suppression of lung cancer cell invasion and migration, and osthole might be a potential agent for preventing the invasion and metastasis of lung cancer. -- Highlights: ? Osthole treatment inhibits lung adenocarcinoma cells migration and invasion. ? Osthole reduces the expression and proteolytic activity of MMP-9. ? Osthole inhibits MMP-9 transcription via suppression of NF-?B binding activity. ? Osthole inhibits I?B? degradation and NF-?B nucleus translocation. ? Osthole suppresses EMT by repressing vimentin and inducing E-cadherin expression.

  16. Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

    SciTech Connect (OSTI)

    Verhaak, Roel GW; Hoadley, Katherine A; Purdom, Elizabeth; Wang, Victoria; Qi, Yuan; Wilkerson, Matthew D; Miller, C Ryan; Ding, Li; Golub, Todd; Mesirov, Jill P; Alexe, Gabriele; Lawrence, Michael; O'Kelly, Michael; Tamayo, Pablo; Weir, Barbara A; Gabriel, Stacey; Winckler, Wendy; Gupta, Supriya; Jakkula, Lakshmi; Feiler, Heidi S; Hodgson, J Graeme; James, C David; Sarkaria, Jann N; Brennan, Cameron; Kahn, Ari; Spellman, Paul T; Wilson, Richard K; Speed, Terence P; Gray, Joe W; Meyerson, Matthew; Getz, Gad; Perou, Charles M; Hayes, D Neil; Network, The Cancer Genome Atlas Research

    2009-09-03

    The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular classification of GBM into Proneural, Neural, Classical, and Mesenchymal subtypes and integrate multidimensional genomic data to establish patterns of somatic mutations and DNA copy number. Aberrations and gene expression of EGFR, NF1, and PDGFRA/IDH1 each define the Classical, Mesenchymal, and Proneural subtypes, respectively. Gene signatures of normal brain cell types show a strong relationship between subtypes and different neural lineages. Additionally, response to aggressive therapy differs by subtype, with the greatest benefit in the Classical subtype and no benefit in the Proneural subtype. We provide a framework that unifies transcriptomic and genomic dimensions for GBM molecular stratification with important implications for future studies.

  17. Simulating QCD at the Physical Point with $N_f=2$ Wilson Twisted Mass Fermions at Maximal Twist

    E-Print Network [OSTI]

    ETM Collaboration; A. Abdel-Rehim; C. Alexandrou; F. Burger; M. Constantinou; P. Dimopoulos; R. Frezzotti; K. Hadjiyiannakou; K. Jansen; C. Kallidonis; B. Kostrzewa; G. Koutsou; M. Mangin-Brinet; M. Petschlies; G. Pientka; G. C. Rossi; C. Urbach; U. Wenger

    2015-07-17

    We present simulations of QCD using Nf=2 dynamical Wilson twisted mass lattice QCD with physical value of the pion mass and at one value of the lattice spacing. Such simulations at ~0.09 fm became possible by adding the clover term to the action. While O(a) improvement is still guaranteed by Wilson twisted mass fermions at maximal twist, the introduction of the clover term reduces cutoff effects related to isospin symmetry breaking. We give results for a set of phenomenologically interesting observables like pseudo-scalar masses and decay constants, quark masses and the anomalous magnetic moments of leptons. We mostly find remarkably good agreement with phenomenology, even though we cannot take the continuum and thermodynamic limits.

  18. Update on a short-distance D^0-meson mixing calculation with $N_f=2+1$ flavors

    E-Print Network [OSTI]

    C. C. Chang; C. Bernard; C. M. Bouchard; A. X. El-Khadra; E. D. Freeland; E. Gámiz; A. S. Kronfeld; J. Laiho; R. S. Van de Water

    2014-12-13

    We present an update on our calculation of the short-distance $D^0$-meson mixing hadronic matrix elements. The analysis is performed on the MILC collaboration's $N_f=2+1$ asqtad configurations. We use asqtad light valence quarks and the Sheikoleslami-Wohlert action with the Fermilab interpretation for the valence charm quark. SU(3), partially quenched, rooted, staggered heavy-meson chiral perturbation theory is used to extrapolate to the chiral-continuum limit. Systematic errors arising from the chiral-continuum extrapolation, heavy-quark discretization, and quark-mass uncertainties are folded into the statistical errors from the chiral-continuum fits with methods of Bayesian inference. A preliminary error budget for all five operators is presented.

  19. Metastatic function of BMP-2 in gastric cancer cells: The role of PI3K/AKT, MAPK, the NF-{kappa}B pathway, and MMP-9 expression

    SciTech Connect (OSTI)

    Kang, Myoung Hee [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Oh, Sang Cheul [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Lee, Hyun Joo [Department of Pathology, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Department of Pathology, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Kang, Han Na; Kim, Jung Lim [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Kim, Jun Suk [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Yoo, Young A., E-mail: ydanbi@korea.ac.kr [Brain Korea 21 Program for Biomedical Science, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)

    2011-07-15

    Bone morphogenetic proteins (BMPs) have been implicated in tumorigenesis and metastatic progression in various types of cancer cells, but the role and cellular mechanism in the invasive phenotype of gastric cancer cells is not known. Herein, we determined the roles of phosphoinositide 3-kinase (PI3K)/AKT, extracellular signal-regulated protein kinase (ERK), nuclear factor (NF)-{kappa}B, and matrix metalloproteinase (MMP) expression in BMP-2-mediated metastatic function in gastric cancer. We found that stimulation of BMP-2 in gastric cancer cells enhanced the phosphorylation of AKT and ERK. Accompanying activation of AKT and ERK kinase, BMP-2 also enhanced phosphorylation/degradation of I{kappa}B{alpha} and the nuclear translocation/activation of NF-{kappa}B. Interestingly, blockade of PI3K/AKT and ERK signaling using LY294002 and PD98059, respectively, significantly inhibited BMP-2-induced motility and invasiveness in association with the activation of NF-{kappa}B. Furthermore, BMP-2-induced MMP-9 expression and enzymatic activity was also significantly blocked by treatment with PI3K/AKT, ERK, or NF-{kappa}B inhibitors. Immunohistochemistry staining of 178 gastric tumor biopsies indicated that expression of BMP-2 and MMP-9 had a significant positive correlation with lymph node metastasis and a poor prognosis. These results indicate that the BMP-2 signaling pathway enhances tumor metastasis in gastric cancer by sequential activation of the PI3K/AKT or MAPK pathway followed by the induction of NF-{kappa}B and MMP-9 activity, indicating that BMP-2 has the potential to be a therapeutic molecular target to decrease metastasis.

  20. Nuclear NF-?B Expression Correlates With Outcome Among Patients With Head and Neck Squamous Cell Carcinoma Treated With Primary Chemoradiation Therapy

    SciTech Connect (OSTI)

    Balermpas, Panagiotis [Department of Radiation Therapy and Oncology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany)] [Department of Radiation Therapy and Oncology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany); Michel, Yvonne [Senckenberg Institute of Pathology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany)] [Senckenberg Institute of Pathology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany); Wagenblast, Jens [Department of Otorhinolaryngology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany)] [Department of Otorhinolaryngology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany); Seitz, Oliver [Department of Maxillofacial Surgery, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany)] [Department of Maxillofacial Surgery, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany); Sipek, Florian; Rödel, Franz; Rödel, Claus [Department of Radiation Therapy and Oncology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany)] [Department of Radiation Therapy and Oncology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany); Fokas, Emmanouil, E-mail: emmanouil.fokas@kgu.de [Department of Radiation Therapy and Oncology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany)] [Department of Radiation Therapy and Oncology, J. W. Goethe – University Frankfurt am Main, Frankfurt (Germany)

    2013-07-15

    Background: To examine whether nuclear NF-?B expression correlates with outcome in patients with head and neck squamous cell carcinoma (HNSCC) treated with primary chemoradiation therapy (CRT). Methods and Materials: Between 2007 and 2010, 101 patients with locally advanced primary HNSCC were treated with definitive simultaneous CRT. Pretreatment biopsy specimens were analyzed for NF-?B p65 (RelA) nuclear immunoreactivity. A sample was assigned to be positive with more than 5% positive nuclear expression. The predictive relevance of NF-?B and clinicopathologic factors for overall survival (OS), progression-free survival (PFS), local progression-free survival (LPFS), and metastasis-free survival (DMFS) was examined by univariate and multivariate analysis. Results: No significant differences between the groups were observed with regard to age, sex, total radiation dose, fractionation mode, total chemotherapy applied, T stage or grading. Patients with p65 nuclear positive biopsy specimens showed significantly a higher rate of lymph node metastasis (cN2c or cN3 status, P=.034). Within a mean follow-up time of 25 months (range, 2.33-62.96 months) OS, PFS, and DMFS were significantly poorer in the p65 nuclear positive group (P=.008, P=.027, and P=.008, respectively). These correlations remained significant in multivariate analysis. Conclusion: NF-?B/p65 nuclear expression is associated with increased lymphatic and hematogenous tumor dissemination and decreased survival in HNSCC patients treated with primary CRT. Our results may foster further investigation of a predictive relevance of NF-?B/p65 and its role as a suitable target for a molecular-based targeted therapy in HNSCC cancer.

  1. Please cite this article in press as: Buyantuyev, A., et al., Multiscale analysis of the urbanization pattern of the Phoenix metropolitan landscape of USA: Time, space and thematic resolution. Landscape Urban Plan. (2009), doi:10.1016/j.landurbplan.2009.1

    E-Print Network [OSTI]

    Wu, Jianguo "Jingle"

    2009-01-01

    of the urbanization pattern of the Phoenix metropolitan landscape of USA: Time, space and thematic resolution of the urbanization pattern of the Phoenix metropolitan landscape of USA: Time, space and thematic resolution of land-cover dynam- ics. Quantification of land-use/land-cover change in Phoenix, Arizona during

  2. Metropolitan Transportation Plan 2035 

    E-Print Network [OSTI]

    Tyler Area Metropolitan Planning Organization

    2009-12-04

    and vertical concentration distributions with the assumptions of continuous emissions, conservation of mass, steady-state conditions, and normal distribution of crosswind and vertical concentrations of pollutants (Cooper and Alley, 2002). The Gaussian...

  3. Lubbock Metropolitan Transportation Plan 

    E-Print Network [OSTI]

    Lubbock Metropolitan Planning Organization

    2007-09-18

    ..............................................................................................................................40 Marsha Sharp Freeway (US 62/82) ...............................................................................................40 Ports-To-Plains Corridor...

  4. Manchester Metropolitan University Sustainability

    E-Print Network [OSTI]

    to create a sustainable University with a positive environmental impact" First Class Environmental and environmental impact. · We've installed two green roofs on our All Saints building to help reduce the risk "Working together to create a sustainable University with a positive environmental impact" First Class

  5. MANCHESTER METROPOLITAN Financial Statements

    E-Print Network [OSTI]

    (includes share of associated company's result) (199,979) (185,386) Impairment on properties in an impairment charge of £7.7m The University has during the past year been planning the implementation of six seven campus areas down to three and will ensure the University has a sustainable estate for the future

  6. Inhibition of inflammatory mediators contributes to the anti-inflammatory activity of KYKZL-1 via MAPK and NF-?B pathway

    SciTech Connect (OSTI)

    Xu, Guang-Lin [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Department of Pharmacology, University of Michigan, Ann Arbor (United States); Du, Yi-Fang; Cheng, Jing; Huan, Lin [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Chen, Shi-Cui [Jinhu Food and Drug Administration, Jiangsu (China); Wei, Shao-Hua [College of Chemistry and Materials Science, Nanjing Normal University, Nanjing (China); Gong, Zhu-Nan, E-mail: biopharmacology@126.com [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Cai, Jie; Qiu, Ting; Wu, Hao; Sun, Ting [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Ao, Gui-Zhen [Department of Medicinal Chemistry, School of Pharmacy, Soochow University, Jiangsu (China)

    2013-10-01

    KYKZL-1, a newly synthesized compound with COX/5-LOX dual inhibition, was subjected to the anti-inflammatory activity test focusing on its modulation of inflammatory mediators as well as intracellular MAPK and NF-?B signaling pathways. In acute ear edema model, pretreatment with KYKZL-1 (p.o.) dose-dependently inhibited the xylene-induced ear edema in mice with a higher inhibition than diclofenac. In a three-day TPA-induced inflammation, KYKZL-1 also showed significant anti-inflammatory activity with inhibition ranging between 20% and 64%. In gastric lesion test, KYKZL-1 elicited markedly fewer stomach lesions with a low index of ulcer as compared to diclofenac in rats. In further studies, KYKZL-1 was found to significantly inhibit the production of NO, PGE{sub 2}, LTB{sub 4} in LPS challenged RAW264.7, which is parallel to its attenuation of the expression of iNOS, COX-2, 5-LOX mRNAs or proteins and inhibition of phosphorylation of p38 and ERK MAPKs and activation of NF-?B. Taken together, our data indicate that KYKZL-1 comprises dual inhibition of COX and 5-LOX and exerts an obvious anti-inflammatory activity with an enhanced gastric safety profile via simultaneous inhibition of phosphorylation of p38 and ERK MAPKs and activation of NF-?B. - Highlights: • KYKZL-1 is designed to exhibit COX/5-LOX dual inhibition. • KYKZL-1 inhibits NO, PGE{sub 2} and LTB{sub 4} and iNOS, COX-2 and 5-LOX mRNAs and MAPKs. • KYKZL-1 inhibits phosphorylation of MAPKs. • KYKZL-1 inactivates NF-?B pathway.

  7. D O M A I NF A L L 2 0 0 4 55555 How a Top Secret Satellite and Fast-Thinking

    E-Print Network [OSTI]

    D O M A I NF A L L 2 0 0 4 55555 How a Top Secret Satellite and Fast-Thinking Navy and Air Force man in the Navy who had worked directly with the top secret Corona Air Force spy satellite, knew what the weather at the Pacific Ocean splashdown site. "When I arrived in Hawaii, I still had my top secret

  8. Moderate extracellular acidification inhibits capsaicin-induced cell death through regulating calcium mobilization, NF-{kappa}B translocation and ROS production in synoviocytes

    SciTech Connect (OSTI)

    Hu, Fen; Yang, Shuang; Zhao, Dan; Zhu, Shuyan; Wang, Yuxiang; Li, Junying

    2012-07-20

    Highlights: Black-Right-Pointing-Pointer Moderate extracellular acidification regulates intracellular Ca{sup 2+} mobilization. Black-Right-Pointing-Pointer Moderate acidification activates NF-{kappa}B nuclear translocation in synoviocytes. Black-Right-Pointing-Pointer Moderate acidification depresses the ROS production induced by capsaicin. Black-Right-Pointing-Pointer Moderate acidification inhibits capsaicin-caused synoviocyte death. -- Abstract: We previously show the expression of transient receptor potential vanilloid 1 (TRPV1) in primary synoviocytes from collagen-induced arthritis (CIA) rats. Capsaicin and lowered extracellular pH from 7.4 to 5.5 induce cell death through TRPV1-mediated Ca{sup 2+} entry and reactive oxygen species (ROS) production. However, under the pathological condition in rheumatoid arthritis, the synovial fluid is acidified to a moderate level (about pH 6.8). In the present study, we examined the effects of pH 6.8 on the TRPV1-mediated cell death. Our finding is different or even opposite from what was observed at pH 5.5. We found that the moderate extracellular acidification (from pH 7.4 to 6.8) inhibited the capsaicin-induced Ca{sup 2+} entry through attenuating the activity of TRPV1. In the mean time, it triggered a phospholipse C (PLC)-related Ca{sup 2+} release from intracellular stores. The nuclear translocation of NF-{kappa}B was found at pH 6.8, and this also depends on PLC activation. Moreover, the capsaicin-evoked massive ROS production and cell death were depressed at pH 6.8, both of which are dependent on the activation of PLC and NF-{kappa}B. Taken together, these results suggested that the moderate extracellular acidification inhibited the capsaicin-induced synoviocyte death through regulating Ca{sup 2+} mobilization, activating NF-{kappa}B nuclear translocation and depressing ROS production.

  9. ROS and NF-{kappa}B are involved in upregulation of IL-8 in A549 cells exposed to multi-walled carbon nanotubes

    SciTech Connect (OSTI)

    Ye Shefang Wu Yihui; Hou Zhenqing; Zhang Qiqing

    2009-02-06

    Carbon nanotubes (CNTs) have potential applications in biosensors, tissue engineering, and biomedical devices because of their unique physico-chemical, electronic and mechanical properties. However, there is limited literature data available concerning the biological properties and toxicity of CNTs. This study aimed to assess the toxicity exhibited by multi-walled CNTs (MWCNTs) and to elucidate possible molecular mechanisms underlying the biological effects of MWCNTs in A549 cells. Exposing A549 cells to MWCNTs led to cell death, changes in cell size and complexity, reactive oxygen species (ROS) production, interleukin-8 (IL-8) gene expression and nuclear factor (NF)-{kappa}B activation. Treatment of A549 cells with antioxidants prior to adding MWCNTs decreased ROS production and abrogated expression of IL-8 mRNA. Pretreatment of A549 cells with NF-{kappa}B inhibitors suppressed MWCNTs-induced IL-8 mRNA expression. These results indicate that MWCNTs are able to induce expression of IL-8 in A549 cells, at least in part, mediated by oxidative stress and NF-{kappa}B activation.

  10. Characterization of Fine Particulate Matter (PM) and Secondary PM Precursor Gases in the Mexico City Metropolitan Area

    SciTech Connect (OSTI)

    Molina, Luisa T.; Molina, Mario J.; Volkamer, Rainer; de Foy, Benjamin; Lei, Wenfang; Zavaka, Miguel; Velasco, Erik

    2008-10-31

    This project was one of three collaborating grants funded by DOE/ASP to characterize the fine particulate matter (PM) and secondary PM precursors in the Mexico City Metropolitan Area (MCMA) during the MILAGRO Campaign. The overall effort of MCMA-2006, one of the four components, focused on i) examination of the primary emissions of fine particles and precursor gases leading to photochemical production of atmospheric oxidants and secondary aerosol particles; ii) measurement and analysis of secondary oxidants and secondary fine PM production, with particular emphasis on secondary organic aerosol (SOA), and iii) evaluation of the photochemical and meteorological processes characteristic of the Mexico City Basin. The collaborative teams pursued the goals through three main tasks: i) analyses of fine PM and secondary PM precursor gaseous species data taken during the MCMA-2002/2003 campaigns and preparation of publications; ii) planning of the MILAGRO Campaign and deployment of the instrument around the MCMA; and iii) analysis of MCMA-2006 data and publication preparation. The measurement phase of the MILAGRO Campaign was successfully completed in March 2006 with excellent participation from the international scientific community and outstanding cooperation from the Mexican government agencies and institutions. The project reported here was led by the Massachusetts Institute of Technology/Molina Center for Energy and the Environment (MIT/MCE2) team and coordinated with DOE/ASP-funded collaborators at Aerodyne Research Inc., University of Colorado at Boulder and Montana State University. Currently 24 papers documenting the findings from this project have been published. The results from the project have improved significantly our understanding of the meteorological and photochemical processes contributing to the formation of ozone, secondary aerosols and other pollutants. Key findings from the MCMA-2003 include a vastly improved speciated emissions inventory from on-road vehicles: the MCMA motor vehicles produce abundant amounts of primary PM, elemental carbon, particle-bound polycyclic aromatic hydrocarbons, carbon monoxide and a wide range of air toxics; the feasibility of using eddy covariance techniques to measure fluxes of volatile organic compounds in an urban core and a valuable tool for validating local emissions inventory; a much better understanding of the sources and atmospheric loadings of volatile organic compounds; the first spectroscopic detection of glyoxal in the atmosphere; a unique analysis of the high fraction of ambient formaldehyde from primary emission sources; characterization of ozone formation and its sensitivity to VOCs and NOx; a much more extensive knowledge of the composition, size distribution and atmospheric mass loadings of both primary and secondary fine PM, including the fact that the rate of MCMA SOA production greatly exceeded that predicted by current atmospheric models; evaluations of significant errors that can arise from standard air quality monitors for O3 and NO2; and the implementation of an innovative Markov Chain Monte Carlo method for inorganic aerosol modeling as a powerful tool to analyze aerosol data and predict gas phase concentrations where these are unavailable. During the MILAGRO Campaign the collaborative team utilized a combination of central fixed sites and a mobile laboratory deployed throughout the MCMA to representative urban and boundary sites to measure trace gases and fine particles. Analysis of the extensive 2006 data sets has confirmed the key findings from MCMA-2002/2003; additionally MCMA-2006 provided more detailed gas and aerosol chemistry and wider regional scale coverage. Key results include an updated 2006 emissions inventory; extension of the flux system to measure fluxes of fine particles; better understanding of the sources and apportionment of aerosols, including contribution from biomass burning and industrial sources; a comprehensive evaluation of metal containing particles in a com

  11. Broken Valence Chiral Symmetry and Chiral Polarization of Dirac Spectrum in N$_f$=12 QCD at Small Quark Mass

    E-Print Network [OSTI]

    Andrei Alexandru; Ivan Horváth

    2014-12-04

    The validity of recently proposed equivalence between valence spontaneous chiral symmetry breaking (vSChSB) and chiral polarization of low energy Dirac spectrum (ChP) in SU(3) gauge theory, is examined for the case of twelve mass-degenerate fundamental quark flavors. We find that the vSChSB-ChP correspondence holds for regularized systems studied. Moreover, our results suggest that vSChSB occurs in two qualitatively different circumstances: there is a quark mass $m_c$ such that for $m > m_c$ the mode condensing Dirac spectrum exhibits standard monotonically increasing density, while for $m_{ch} < m < m_c$ the peak around zero separates from the bulk of the spectrum, with density showing a pronounced depletion at intermediate scales. Valence chiral symmetry restoration may occur at yet smaller masses $m < m_{ch}$, but this has not yet been seen by overlap valence probe, leaving the $m_{ch}=0$ possibility open. The latter option could place massless N$_f$=12 theory outside of conformal window. Anomalous behavior of overlap Dirac spectrum for $m_{ch} < m < m_c$ is qualitatively similar to one observed previously in zero and few-flavor theories as an effect of thermal agitation.

  12. Involvement of a chromatin modifier in response to mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cell injury: Probably an indirect action via the regulation of NF?B/FasL circuitry

    SciTech Connect (OSTI)

    Chen, Shiwei [Department of Urology, 174th Hospital of PLA, Fujian 361001 (China)] [Department of Urology, 174th Hospital of PLA, Fujian 361001 (China); Dong, Yushu [Department of Neurosurgery, 463rd Hospital of PLA, Shenyang 110042 (China)] [Department of Neurosurgery, 463rd Hospital of PLA, Shenyang 110042 (China); Xu, Chun; Jiang, Liming; Chen, Yongjie; Jiang, Cheng [Department of Urology, 174th Hospital of PLA, Fujian 361001 (China)] [Department of Urology, 174th Hospital of PLA, Fujian 361001 (China); Hou, Wugang, E-mail: gangwuhou@163.com [Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032 (China)] [Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032 (China); Li, Wei, E-mail: liweipepeyato@163.com [Department of Human Anatomy, Histology and Embryology, Fourth Military Medical University, Xi’an 710032 (China)] [Department of Human Anatomy, Histology and Embryology, Fourth Military Medical University, Xi’an 710032 (China)

    2013-11-01

    Highlights: •MTA1 expression is upregulated in SCs upon MEHP treatment. •Knockdown of MTA1 in SCs impairs the MEHP-induced NF?B signaling activation. •Knockdown of MTA1 inhibits recruitment of NF?B onto FasL promoter in MEHP-treated SCs. -- Abstract: The Fas/FasL signaling pathway, controlled by nuclear factor-?B (NF?B) at the transcriptional level, is critical for triggering germ cell apoptosis in response to mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cell (SC) injury, but the exact regulation mechanism remain unknown. Here, we discovered that expression level of Metastasis associated protein 1 (MTA1), a component of the Mi-2/nucleosome remodeling and deacetylase complex, was upregulated in SCs during the early recovery after MEHP exposure. This expression change was in line with the dynamic changes in germ cell apoptosis in response to MEHP treatment. Furthermore, a knockdown of MTA1 by RNAi in SCs was found to impair the MEHP-induced early activation of NF?B pathway and abolish the recruitment of NF?B onto FasL promoter, which consequently diminished the MEHP-triggered FasL induction. Considering that Fas/FasL is a well characterized apoptosis initiating signaling during SCs injury, our results point to a potential “switch on” effect of MTA1, which may govern the activation of NF?B/FasL cascade in MEHP-insulted SCs. Overall, the MTA1/NF?B/FasL circuit may serve as an important defensive/repairing mechanism to help to control the germ cell quality after SCs injury.

  13. Rosiglitazone attenuates NF-{kappa}B-dependent ICAM-1 and TNF-{alpha} production caused by homocysteine via inhibiting ERK{sub 1/2}/p38MAPK activation

    SciTech Connect (OSTI)

    Bai, Yong-Ping [Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China); Liu, Yu-Hui [Department of Pharmacology, College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330006 (China); Chen, Jia [Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China); Song, Tao [Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078 (China); You, Yu [Department of Digestive Medicine, Xiangya Second Hospital, Central South University, Changsha, Hunan 410078 (China); Tang, Zhen-Yan [Department of Urologic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China); Li, Yuan-Jian [Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078 (China); Zhang, Guo-Gang [Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China)]. E-mail: xyzgg2006@sina.com

    2007-08-17

    Previous studies demonstrated an important interaction between nuclear factor-kappaB (NF-{kappa}B) activation and homocysteine (Hcy)-induced cytokines expression in endothelial cells and vascular smooth muscle cells. However, the underlying mechanism remains illusive. In this study, we investigated the effects of Hcy on NF-{kappa}B-mediated sICAM-1, TNF-{alpha} production and the possible involvement of ERK{sub 1/2}/p38MAPK pathway. The effects of rosiglitazone intervention were also examined. Our results show that Hcy increased the levels of sICAM-1 and TNF-{alpha} in cultured human umbilical vein endothelial cells (HUVECs) in a time- and concentration-dependent manner. This effect was significantly depressed by rosiglitazone and different inhibitors (PDTC, NF-{kappa}B inhibitor; PD98059, MEK inhibitor; SB203580, p38MAPK specific inhibitor; and staurosporine, PKC inhibitor). Next, we investigated the effect of Hcy on ERK{sub 1/2}/p38MAPK pathway and NF-{kappa}B activity in HUVECs. The results show that Hcy activated both ERK{sub 1/2}/p38MAPK pathway and NF-{kappa}B-DNA-binding activity. These effects were markedly inhibited by rosiglitazone as well as other inhibitors (SB203580, PD98059, and PDTC). Further, the pretreatment of staurosporine abrogated ERK{sub 1/2}/p38MAPK phosphorylation, suggesting that Hcy-induced ERK{sub 1/2}/p38MAPK activation is associated with PKC activity. Our results provide evidence that Hcy-induced NF-{kappa}B activation was mediated by activation of ERK{sub 1/2}/p38MAPK pathway involving PKC activity. Rosiglitazone reduces the NF-{kappa}B-mediated sICAM-1 and TNF-{alpha} production induced by Hcy via inhibition of ERK{sub 1/2}/p38MAPK pa0011thw.

  14. Anti-neuroinflammatory efficacy of the aldose reductase inhibitor FMHM via phospholipase C/protein kinase C-dependent NF-?B and MAPK pathways

    SciTech Connect (OSTI)

    Zeng, Ke-Wu [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191 (China); Li, Jun [Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029 (China); Dong, Xin; Wang, Ying-Hong; Ma, Zhi-Zhong; Jiang, Yong; Jin, Hong-Wei [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191 (China); Tu, Peng-Fei, E-mail: pengfeitu@vip.163.com [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191 (China); Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029 (China)

    2013-11-15

    Aldose reductase (AR) has a key role in several inflammatory diseases: diabetes, cancer and cardiovascular diseases. Therefore, AR inhibition seems to be a useful strategy for anti-inflammation therapy. In the central nervous system (CNS), microglial over-activation is considered to be a central event in neuroinflammation. However, the effects of AR inhibition in CNS inflammation and its underlying mechanism of action remain unknown. In the present study, we found that FMHM (a naturally derived AR inhibitor from the roots of Polygala tricornis Gagnep.) showed potent anti-neuroinflammatory effects in vivo and in vitro by inhibiting microglial activation and expression of inflammatory mediators. Mechanistic studies showed that FMHM suppressed the activity of AR-dependent phospholipase C/protein kinase C signaling, which further resulted in downstream inactivation of the I?B kinase/I?B/nuclear factor-kappa B (NF-?B) inflammatory pathway. Therefore, AR inhibition-dependent NF-?B inactivation negatively regulated the transcription and expression of various inflammatory genes. AR inhibition by FMHM exerted neuroprotective effects in lipopolysaccharide-induced neuron–microglia co-cultures. These findings suggested that AR is a potential target for neuroinflammation inhibition and that FMHM could be an effective agent for treating or preventing neuroinflammatory diseases. - Highlights: • FMHM is a natural-derived aldose reductase (AR) inhibitor. • FMHM inhibits various neuroinflammatory mediator productions in vitro and in vivo. • FMHM inhibits neuroinflammation via aldose reductase/PLC/PKC-dependent NF-?B pathway. • FMHM inhibits neuroinflammation via aldose reductase/PLC/PKC-dependent MAPK pathway. • FMHM protects neurons against inflammatory injury in microglia-neuron co-cultures.

  15. Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2–NF?B pathways

    SciTech Connect (OSTI)

    Das, Joydeep; Ghosh, Jyotirmoy; Roy, Anandita; Sil, Parames C.

    2012-04-01

    Mangiferin, a xanthone glucoside, is well known to exhibit antioxidant, antiviral, antitumor, anti-inflammatory and gene-regulatory effects. In the present study, we isolated mangiferin from the bark of Mangifera indica and assessed its beneficial role in galactosamine (GAL) induced hepatic pathophysiology. GAL (400 mg/kg body weight) exposed hepatotoxic rats showed elevation in the activities of serum ALP, ALT, levels of triglycerides, total cholesterol, lipid-peroxidation and reduction in the levels of serum total proteins, albumin and cellular GSH. Besides, GAL exposure (5 mM) in hepatocytes induced apoptosis and necrosis, increased ROS and NO production. Signal transduction studies showed that GAL exposure significantly increased the nuclear translocation of NF?B and elevated iNOS protein expression. The same exposure also elevated TNF-?, IFN-?, IL-1?, IL-6, IL-12, IL-18 and decreased IL-10 mRNA expressions. Furthermore, GAL also decreased the protein expression of Nrf2, NADPH:quinine oxidoreductase-1, heme oxygenase-1 and GST?. However, mangiferin administration in GAL intoxicated rats or coincubation of hepatocytes with mangiferin significantly altered all these GAL-induced adverse effects. In conclusion, the hepatoprotective role of mangiferin was due to induction of antioxidant defense via the Nrf2 pathway and reduction of inflammation via NF?B inhibition. Highlights: ?Galactosamine induces hepatocytes death via oxidative and nitrosative stress. ?Mangiferin exerts hepatoprotective effect/antioxidant defense via Nrf2 pathway. ?Mangiferin exerts anti-inflammatory responses by inhibiting NF-?B. ?Mangiferin suppresses galactosamine-induced repression of IL-10 mRNA.

  16. Hadron-Hadron Interactions from $N_f=2+1+1$ Lattice QCD: isospin-2 $\\pi\\pi$ scattering length

    E-Print Network [OSTI]

    Helmes, C; Knippschild, B; Liu, C; Liu, J; Liu, L; Urbach, C; Ueding, M; Wang, Z; Werner, M

    2015-01-01

    We present results for the $I=2$ $\\pi\\pi$ scattering length using $N_f=2+1+1$ twisted mass lattice QCD for three values of the lattice spacing and a range of pion mass values. Due to the use of Laplacian Heaviside smearing our statistical errors are reduced compared to previous lattice studies. A detailed investigation of systematic effects such as discretisation effects, volume effects, and pollution of excited and thermal states is performed. After extrapolation to the physical point using chiral perturbation theory at NLO we obtain $M_\\pi a_0=-0.0442(2)_\\mathrm{stat}(^{+4}_{-0})_\\mathrm{sys}$.

  17. NF_Eder_2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMass map shines light on771/6/14 Contact: Janet Lambert4 FLCNETL-ORD4NEVIS-NEWS MEDIAmail3

  18. TGF-{beta}1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-{kappa}B/IL-6/MMP-2

    SciTech Connect (OSTI)

    Binker, Marcelo G.; CBRHC Research Center, Buenos Aires ; Binker-Cosen, Andres A.; Gaisano, Herbert Y.; Cosen, Rodica H. de; Cosen-Binker, Laura I.

    2011-02-04

    Research highlights: {yields} Rac1 mediates TGF-{beta}1-induced SW1990 invasion through MMP-2 secretion and activation. {yields} NADPH-generated ROS act downstream of Rac1 in TGF-{beta}1-challenged SW1990 cells. {yields} TGF-{beta}1-stimulated ROS activate NF-{kappa}B in SW1990 cells. {yields} NF{kappa}B-induced IL-6 release is required for secretion and activation of MMP-2 in SW1990 cells. -- Abstract: Human pancreatic cancer invasion and metastasis have been found to correlate with increased levels of active matrix metalloproteinase 2 (MMP-2). The multifunctional cytokine transforming growth factor beta 1 (TGF-{beta}1) has been shown to increase both secretion of MMP-2 and invasion by several pancreatic cancer cell types. In the present study, we investigated the signaling pathway involved in TGF-{beta}1-promoted MMP-2 secretion and invasion by human pancreatic cancer cells SW1990. Using specific inhibitors, we found that stimulation of these tumor cells with TGF-{beta}1 induced secretion and activation of the collagenase MMP-2, which was required for TGF-{beta}1-stimulated invasion. Our results also indicate that signaling events involved in TGF-{beta}1-enhanced SW1990 invasiveness comprehend activation of Rac1 followed by generation of reactive oxygen species through nicotinamide adenine dinucleotide phosphate-oxidase, activation of nuclear factor-kappa beta, release of interleukin-6, and secretion and activation of MMP-2.

  19. 4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-{kappa}B and ERK/MAPK

    SciTech Connect (OSTI)

    Chen Zhihua [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Na, Hye-Kyung [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Hurh, Yeon-Jin [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Surh, Young-Joon [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of)]. E-mail: surh@plaza.snu.ac.kr

    2005-10-01

    Catechol estrogens, the hydroxylated metabolites of 17{beta}-estradiol (E{sub 2}), have been considered to be implicated in estrogen-induced carcinogenesis. 4-Hydroxyestradiol (4-OHE{sub 2}), an oxidized metabolite of E{sub 2} formed preferentially by cytochrome P450 1B1, reacts with DNA to form depurinating adducts thereby exerting genotoxicity and carcinogenicity. 4-OHE{sub 2} undergoes 2-electron oxidation to quinone via semiquinone, and during this process, reactive oxygen species (ROS) can be generated to cause DNA damage and cell death. In the present study, 4-OHE{sub 2} was found to elicit cytotoxicity in cultured human mammary epithelial (MCF-10A) cells, which was blocked by the antioxidant trolox. MCF-10A cells treated with 4-OHE{sub 2} exhibited increased intracellular ROS accumulation and 8-oxo-7,8-dihydroxy-2'-deoxyguanosine formation, and underwent apoptosis as determined by poly(ADP-ribose)polymerase cleavage and disruption of mitochondrial transmembrane potential. The redox-sensitive transcription factor nuclear factor {kappa}B (NF-{kappa}B) was transiently activated by 4-OHE{sub 2} treatment. Cotreatment of MCF-10A cells with the NF-{kappa}B inhibitor, L-1-tosylamido-2-phenylethyl chloromethyl ketone, exacerbated 4-OHE{sub 2}-induced cell death. 4-OHE{sub 2} also caused transient activation of extracellular signal-regulated protein kinases (ERK) involved in transmitting cell survival or death signals. A pharmacological inhibitor of ERK aggravated the 4-OHE{sub 2}-induced cytotoxicity, supporting the pivotal role of ERK in protecting against catechol estrogen-induced oxidative cell death.

  20. Agent-based model forecasts aging of the population of people who inject drugs in metropolitan Chicago and changing prevalence of hepatitis C infections

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Gutfraind, Alexander; Boodram, Basmattee; Prachand, Nikhil; Hailegiorgis, Atesmachew; Dahari, Harel; Major, Marian E.; Kaderali, Lars

    2015-09-30

    People who inject drugs (PWID) are at high risk for blood-borne pathogens transmitted during the sharing of contaminated injection equipment, particularly hepatitis C virus (HCV). HCV prevalence is influenced by a complex interplay of drug-use behaviors, social networks, and geography, as well as the availability of interventions, such as needle exchange programs. To adequately address this complexity in HCV epidemic forecasting, we have developed a computational model, the Agent-based Pathogen Kinetics model (APK). APK simulates the PWID population in metropolitan Chicago, including the social interactions that result in HCV infection. We used multiple empirical data sources on Chicago PWID tomore »build a spatial distribution of an in silico PWID population and modeled networks among the PWID by considering the geography of the city and its suburbs. APK was validated against 2012 empirical data (the latest available) and shown to agree with network and epidemiological surveys to within 1%. For the period 2010–2020, APK forecasts a decline in HCV prevalence of 0.8% per year from 44(±2)% to 36(±5)%, although some sub-populations would continue to have relatively high prevalence, including Non-Hispanic Blacks, 48(±5)%. The rate of decline will be lowest in Non-Hispanic Whites and we find, in a reversal of historical trends, that incidence among non-Hispanic Whites would exceed incidence among Non-Hispanic Blacks (0.66 per 100 per years vs 0.17 per 100 person years). APK also forecasts an increase in PWID mean age from 35(±1) to 40(±2) with a corresponding increase from 59(±2)% to 80(±6)% in the proportion of the population >30 years old. Our research highlight the importance of analyzing sub-populations in disease predictions, the utility of computer simulation for analyzing demographic and health trends among PWID and serve as a tool for guiding intervention and prevention strategies in Chicago, and other major cities.« less

  1. 2030 Metropolitan Transportation Plan for the Albuquerque Metropolitan Planning Area 

    E-Print Network [OSTI]

    Mid-Region Metropolitan Planning Organization

    2007-04-26

    Transportation Planner Diane Scena, Trails Planner Mark A. Sprick, AICP, Transportation Planning Manager Barbara Thomas, Secretary-Transportation/Water Kendra Watkins, Transportation Planner Eric Webster, Transportation Planner ?4?Q?F?D?J?B?M???5?I?B?O?L... Manager Bruce Rizzieri, Regional Transit Manager Tony Sylvester, AICP, Special Projects Planner Loretta Tollefson, AICP, Special Projects Manager-Mid-Region Rural Transportation Planning Organization ?4?Q?F?D?J?B?M???5?I?B?O?L?T???U?P???U?I?F???.?3...

  2. Abilene Metropolitan Area Metropolitan Transportation Plan 2010-2035 

    E-Print Network [OSTI]

    Abilene Metropolitan Planning Organization

    2010-01-12

    Lindley, former Abilene City Engineer MPO Staff (Non-Voting) Robert Allen, Abilene MPO Transportation Planning Director Dyess AFB SH 351 SH 351 FM 10 82 Jones County JonesCounty Jones County Jones County Jones County Te xt Jones County Jones... Area Urbanized Area Boundary county lines City Limits Freeways and Expressways Major Streets and Highways Railroad 0241Miles Tye Potosi Caps Dyess AFB Abilene Regional Airport Abilene ??? 20 ??? 20 ??? 20 Hamby State Prisons Lake Fort Phantom Hill...

  3. Prepared for: New York Metropolitan

    E-Print Network [OSTI]

    Qiu, Weigang

    .............................................................................................................................2-2 Power................................................................................................................................2-2 Purchase Recommendations

  4. Mobility 2035 Metropolitan Transportation Plan 

    E-Print Network [OSTI]

    Killeen-Temple Urban Transportation Study

    2009-05-20

    braking while decelerating or traveling downhill will be captured with some conversion losses. 9 CHAPTER IV DATA GATHERING To investigate the effect of electrifying existing interstate/freeway transportation, as a start, the existing traffic... on the grid by conveying on the new guideway freight and passenger vehicles currently driven on the freeways and interstate highways. The calculation required total vehicle miles traveled (VMT) and the hourly volume pattern by each vehicle class and road...

  5. Landscape viewing in metropolitan Boston

    E-Print Network [OSTI]

    Teas, Wendy Ann

    1990-01-01

    This thesis recognizes the importance of landscape viewing, especially as a solitary act of contemplation. It suggests the creation of a place from which to gaze upon a vast landscape. It postulates that an observation ...

  6. San Angelo Metropolitan Transportation Plan 

    E-Print Network [OSTI]

    San Angelo Metropolitan Planning Organization

    2009-11-16

    2-5 Projected Population for Tom Green County and the San Angelo MTP Planning Area ....................................................................................................................................................... 25 Table 2-6... Table 6-3 Estimated Costs for all LCI-related Improvements ...................................................... 84 Table 10-1 Financial Plan Roadway by Category ...................................................................... 118 Table 10-2...

  7. Hypo-responsiveness of interleukin-8 production in human embryonic epithelial intestine 407 cells independent of NF-{kappa}B pathway: New lessons from endotoxin and ribotoxic deoxynivalenol

    SciTech Connect (OSTI)

    Moon, Yuseok [Department of Microbiology and Immunology, Medical Research Institute, Pusan National University School of Medicine, Busan, 602-739 (Korea, Republic of)], E-mail: moon@pusan.ac.kr; Yang, Hyun; Park, Seung-Hwan [Department of Microbiology and Immunology, Medical Research Institute, Pusan National University School of Medicine, Busan, 602-739 (Korea, Republic of)

    2008-08-15

    Mucosal epithelium senses external toxic insults and transmits the danger signals into the epithelial cells in order to activate a broad range of inflammatory responses. However, pre-exposure to the commensal endotoxins can induce inflammatory tolerance and maintain the homeostasis without excessive immune responses. We recently reported that ribotoxin deoxynivalenol (DON) and its derivatives elicited the pro-inflammatory response as the mucosal insults in human epithelial cells. Taking the knowledge into consideration, we tested the hypothesis that endotoxin pre-exposure can attenuate ribotoxin-induced epithelial interleukin-8 (IL-8) production via a tolerance mechanism. Pre-exposure to endotoxin repressed IL-8 release and its gene expression. However, inflammatory tolerance was not mediated by the attenuated NF-{kappa}B activation which has been generally recognized as the major mediator of LPS-mediated toll-like receptor (TLR) signaling pathway. Instead, pre-exposure to endotoxin was observed to trigger the delayed induction of peroxisome proliferator-activated receptor gamma (PPAR-{gamma}) which contributed to the diminished IL-8 production in the human epithelial cells. Moreover, endogenous PPAR-{gamma} agonist suppressed toxicant-mediated interleukin-8 production and IL-8 mRNA stability. Taken together, endotoxin induced hypo-production of pro-inflammatory cytokine IL-8 in the human epithelial cells, which was associated with the delayed activation of PPAR-{gamma} expression by pre-existing endotoxin.

  8. Dietary turmeric modulates DMBA-induced p21{sup ras}, MAP kinases and AP-1/NF-{kappa}B pathway to alter cellular responses during hamster buccal pouch carcinogenesis

    SciTech Connect (OSTI)

    Garg, Rachana; Ingle, Arvind; Maru, Girish

    2008-11-01

    The chemopreventive efficacy of turmeric has been established in experimental systems. However, its mechanism(s) of action are not fully elucidated in vivo. The present study investigates the mechanism of turmeric-mediated chemoprevention in 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis at 2, 4, 6, 10 and 12 weeks. Dietary turmeric (1%) led to decrease in DMBA-induced tumor burden and multiplicity, and enhanced the latency period in parallel, to its modulatory effects on oncogene products and various cellular responses during HBP tumorigenesis. DMBA-induced expression of ras oncogene product, p21 and downstream target, the mitogen-activated protein kinases were significantly decreased by turmeric during HBP carcinogenesis. Turmeric also diminished the DMBA-induced mRNA expression of proto-oncogenes (c-jun, c-fos) and NF-{kappa}B, leading to decreased protein levels and in further attenuation of DMBA-induced AP-1/NF-{kappa}B DNA-binding in the buccal pouch nuclear extracts. Besides, buccal pouch of hamsters receiving turmeric diet showed significant alterations in DMBA-induced effects: (a) decrease in cell proliferation (diminished PCNA and Bcl2 expression), (b) enhanced apoptosis (increased expression of Bax, caspase-3 and apoptotic index), (c) decrease in inflammation (levels of Cox-2, the downstream target of AP-1/NF-{kappa}B, and PGE2) and (d) aberrant expression of differentiation markers, the cytokeratins (1, 5, 8, and 18). Together, the protective effects of dietary turmeric converge on augmenting apoptosis of the initiated cells and decreasing cell proliferation in DMBA-treated animals, which in turn, is reflected in decreased tumor burden, multiplicity and enhanced latency period. Some of these biomarkers are likely to be helpful in monitoring clinical trials and evaluating drug effect measurements.

  9. Activation of ROS/NF-{kappa}B and Ca{sup 2+}/CaM kinase II are necessary for VCAM-1 induction in IL-1{beta}-treated human tracheal smooth muscle cells

    SciTech Connect (OSTI)

    Luo, S.-F. [Department of Internal Medicine, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China); Chang, C.-C.; Lee, I-T. [Department of Physiology and Pharmacology, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China); Lee, C.-W. [Department of Nursing, Division of Basic Medical Sciences, Chang Gung Institute of Technology, Chia-Yi, Taiwan (China); Lin, W.-N. [Department of Physiology and Pharmacology, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China); Lin, C.-C. [Department of Anesthetics, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China); Yang, C.-M. [Department of Physiology and Pharmacology, Chang Gung University, Kwei-San, Tao-Yuan, Taiwan (China)], E-mail: chuenmao@mail.cgu.edu.tw

    2009-05-15

    Histone acetylation regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) plays a critical role in the expression of inflammatory genes, such as vascular cell adhesion molecule-1 (VCAM-1). Oxidative processes have been shown to induce VCAM-1 expression. Here, we investigated the mechanisms underlying IL-1{beta}-induced VCAM-1 expression in human tracheal smooth muscle cells (HTSMCs). Our results showed that IL-1{beta} enhanced HTSMCs-monocyte adhesion through up-regulation of VCAM-1, which was inhibited by pretreatment with selective inhibitors of PKC{alpha} (Goe6976), c-Src (PP1), NADPH oxidase [diphenylene iodonium (DPI) and apocynin (APO)], intracellular calcium chelator (BAPTA/AM), PI-PLC (U73122), CaM (calmidazolium chloride), CaM kinase II (KN62), p300 (garcinol), NF-{kappa}B (Bay11-7082), HDAC (trichostatin A), and ROS scavenger [N-acetyl-L-cysteine (NAC)] or transfection with siRNAs of MyD88, PKC{alpha}, Src, p47{sup phox}, p300, and HDAC4. Moreover, IL-1{beta} stimulated NF-{kappa}B and CaMKII phosphorylation through MyD88-dependent PI-PLC/PKC{alpha}/c-Src/ROS and PI-PLC/Ca{sup 2+}/CaM pathways, respectively. Activation of NF-{kappa}B and CaMKII may eventually lead to the acetylation of histone residues and phosphorylation of histone deacetylases. These findings suggested that IL-1{beta} induced VCAM-1 expression via these multiple signaling pathways in HTSMCs. Blockade of these pathways may reduce monocyte adhesion via VCAM-1 suppression and attenuation of the inflammatory responses in airway diseases.

  10. The REMOTE SENSlNf

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield Municipal Gas &SCE-SessionsSouth DakotaRobbins and700, 1. .&. ' , c 1afr -.:2yL: a,;. -:-1 / .'

  11. Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-{kappa}B translocation

    SciTech Connect (OSTI)

    Jawan, Bruno [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Kao, Y.-H. [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Department of Biological Sciences, National Sun Yat-Sen University, 70 Lien-Hai Road, Kaohsiung 804, Taiwan (China); Goto, Shigeru [Department of Surgery and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Department of Surgery, Iwao Hospital, 3059-1 Kawakami, Yufuin, Oita 879-5102 (Japan); Pan, M.-C. [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Lin, Y.-C.; Hsu, L.-W.; Nakano, Toshiaki; Lai, C.-Y.; Sun, C.-K.; Cheng, Y.-F. [Department of Surgery and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Tai, M.-H. [Department of Biological Sciences, National Sun Yat-Sen University, 70 Lien-Hai Road, Kaohsiung 804, Taiwan (China); Department of Medical Research and Education, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Road, Kaohsiung 813, Taiwan (China)] (and others)

    2008-06-15

    Propofol (PPF), a widely used intravenous anesthetic for induction and maintenance of anesthesia during surgeries, was found to possess suppressive effect on host immunity. This study aimed at investigating whether PPF plays a modulatory role in the lipopolysaccharide (LPS)-induced inflammatory cytokine expression in a cell line of rat hepatocytes. Morphological observation and viability assay showed that PPF exhibits no cytotoxicity at concentrations up to 300 {mu}M after 48 h incubation. Pretreatment with 100 {mu}M PPF for 24 h prior to LPS stimulation was performed to investigate the modulatory effect on LPS-induced inflammatory gene production. The results of semi-quantitative RT-PCR demonstrated that PPF pretreatment significantly suppressed the LPS-induced toll-like receptor (TLR)-4, CD14, tumor necrosis factor (TNF)-{alpha}, and granulocyte-macrophage colony-stimulating factor (GM-CSF) gene expression. Western blotting analysis showed that PPF pretreatment potentiated the LPS-induced TLR-4 downregulation. Flow cytometrical analysis revealed that PPF pretreatment showed no modulatory effect on the LPS-upregulated CD14 expression on hepatocytes. In addition, PPF pretreatment attenuated the phosphorylation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and I{kappa}B{alpha}, as well as the nuclear translocation of NF-{kappa}B primed by LPS. Moreover, addition of PD98059, a MAPK kinase inhibitor, significantly suppressed the LPS-induced NF-{kappa}B nuclear translocation and GM-CSF production, suggesting that the PPF-attenuated GM-CSF production in hepatocytes may be attributed to its suppressive effect on MAPK/ERK signaling pathway. In conclusion, PPF as an anesthetic may clinically benefit those patients who are vulnerable to sepsis by alleviating sepsis-related inflammatory response in livers.

  12. A Briefing Notebook for Metropolitan Planning

    E-Print Network [OSTI]

    Handy, Susan L.

    . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .40 System Management and Operations (M&O) . . . . . . . . . . . . . . . .42 Transportation Demand listing highway and transit capital investments, it requires developing strategies for operating, managing Policy and Planning Issues . . . . . . . . . . . . . . . . . . . . . . .10 Air Quality

  13. Metropolitan Community College (Missouri-all locations)

    E-Print Network [OSTI]

    GE3N PHYS 104 Foundations of Physical Science 4 GE3N PHYS 106 General Astronomy 5 GE3N CHEM 105 Problems 3 PHSX 114 College Physics 1 4 PHYS 130 College Physics 5 PHSX 211 General Physics & 216 4 PHYS 220 General Physics 5 Goal 2: Communication (3 Units) -two from outc

  14. Amarillo Metropolitan Transportation Plan 2010-2035 

    E-Print Network [OSTI]

    Amarillo Metropolitan Planning Organization

    2009-10-15

    With multiple advancements in technology and the wide range of genres available to choose from, younger adults may be shifting to other platforms of radio. If younger generations begin to shift towards digital streaming ...

  15. Metropolitan Transportation Plan 2005-2030 

    E-Print Network [OSTI]

    Santa Fe Metropolitan Planning Organization

    1999-01-01

    to Camino Entrada and left turns to and from Airport Rd. ? The extension of South Meadows north to Rufina should be completed as well as the connection between Agua Fria Rd and County Road 62 at NM 599. ? Traffic calming measures are recommended for Lopez... Members County Commission Members Councilor Patti Bushee, Chair Commissioner Harry Montoya, Vice Chair Councilor Miguel Chavez Commissioner Paul Campos Councilor David Coss Commissioner Jack Sullivan Councilor Rebecca Wurzburger Commissioner Virginia Vigil...

  16. Metropolitan Spillover and California's Central Valley

    E-Print Network [OSTI]

    Kroll, Cynthia A.

    1985-01-01

    SUTTER 67.0% TEHAMA 36.6% TULARE 62.4% YOLO 81.9% YUBA 71 4%San Joaquin, Stanislaus, and Tulare counties (see Figure 1).JOAQUIN STANISLAUS SUTTER TEHAMA TULARE YOLO YUBA _\\. _\\-—\\_

  17. Connections 2035 The Waco Metropolitan Transportation Plan 

    E-Print Network [OSTI]

    Waco Metropolitan Planning Organization

    2010-02-03

    LIST OF FIGURES Page 1.1 Schematics of a thermocouple circuit formed from two dissimilar materials X and Y. (a) Illustration of Seebeck effect for electricity generation and (b) illustration of Peltier cooling... and (b) Illustration of Peltier cooling.13-16 3 The generation of electricity in a thermoelectric materials is based on Seebeck effects. Figure 1.1 show a thermocouple circuit formed from two dissimilar materials X and Y...

  18. Metropolitan Community College (Missouri-all locations)

    E-Print Network [OSTI]

    & 236 Engineering Physics 4 PHYS 221 Engineering Physics 2 5 GE3N CHEM 130 Chemistry 5 CHEM 111 General CHEM S330 & S331 Organic Chemistry 5 CHEM 220 Organic Chemistry 1 5 Petroleum Engineering: KU Course OF KANSAS B.S. in Chemical & Petroleum Engineering (Subplans of Environmental, Biomedical, Petroleum, Pre

  19. Laredo 2010-2035 Metropolitan Transportation Plan 

    E-Print Network [OSTI]

    Laredo Urban Transportation Study

    2009-12-11

    ?Rivera,?PE? Linda?Vela The?preparation?and?publication?of?this?report?was?financed?in?part?through?grants?from?the? Federal?Highway?Administration,?the?Federal?Transit?Administration,?and?the?Texas? Department?of?Transportation.?All?opinions,?findings,?and...?conclusions?presented?in?this?report? reflect?the?view?of?the?Plan?authors?and?do?not?necessarily?reflect?the?official?views?or?policy? of?the?Federal?Highway?Administration,?the?Federal?Transit?Administration,?or?the?Texas? Department?of?Transportation.? ? ? ? ? ? ? ? ? ? ? THIS...

  20. 2010-2035 Metropolitan Transportation Plan 

    E-Print Network [OSTI]

    Bryan/College Station Metropolitan Planning Organization

    2009-12-02

    of instruments and spray nozzle sites ..................................................... 31 Fig. 17. Crosswind vapor concentrations near ground at x = 90 m .................................. 32 Fig. 18. Experimental setup of Nov 2007 MKOPSC LNG spill test...

  1. Metropolitan Transportation Plan 2005-2030 

    E-Print Network [OSTI]

    Midland-Odessa Transportation Organization

    2004-12-08

    This study evaluated the effect of typical production practices during transport of cattle on the resulting incidence of pathogenic bacteria in cattle and their resulting carcasses. Various factors, including type of animal, body condition score...

  2. Towards Smarter Metropolitan Emergency Response Marcus Poulton

    E-Print Network [OSTI]

    Roussos, George

    of London Malet Street, London WC1E 7HX marcus.poulton@gmail.com George Roussos Birkbeck College, University of London Malet Street, London WC1E 7HX gr@dcs.bbk.ac.uk ABSTRACT A core ingredient of Smart Cities on extensive command and control infrastructure that links into the healthcare and transportation systems

  3. Metropolitan Transportation Plan 2009-2035 

    E-Print Network [OSTI]

    South Central Planning and Development Commission

    2009-05-14

    taxes?collected?in?their?jurisdictions?to?fund?road?and?street?improvements.??These?projects?are? primarily?maintenance?projects?(i.e.,?resurfacing)?aimed?at?making?better?use?of?existing? facilities.? ? Community?Development?Block?Grants? The... TRANSPORTATION PLAN] 4 Tables Table Page 3.1 Road Improvement Cost Estimates 15 3.2 Historical Federal and State Funding 20 3.3 Stage I (2009-2014) ? Improvement Program 23 3.4 Stage II (2015-2020) ? Improvement Program...

  4. Las Cruces MPO 2040 Metropolitan Transportation Plan 

    E-Print Network [OSTI]

    Las Cruces Metropolitan Planning Organization

    2010-06-09

    /or regionally significant transportation projects determined by the Policy Committee. The list of projects is created in cooperation with residents, local governments, and the New Mexico Department of Transportation (NMDOT). The TIP must be in compliance... short and long-term strategies for maintaining and enhancing the area's transportation system and ? Develop implementation strategies and performance measures that will help achieve the desired results. TRANSPORT 2040 7 ?Y Existing...

  5. Metropolitan Transportation Plan Fiscal Year 2010 - 2035 

    E-Print Network [OSTI]

    Corpus Christi Metropolitan Planning Organization

    2009-12-03

    .................................................................................................................... 23 Urban Action Plan ........................................................................................................................... 24 Table 1 - Functional Systems in Urbanized Areas... ........................................................................... 28 Critical Incident Planning ................................................................................................................ 29 CHAPTER 5 PUBLIC TRANSPORTATION...

  6. 2010-2035 Metropolitan Transportation Plan 

    E-Print Network [OSTI]

    Hidalgo County Metropolitan Planning Organization

    2009-12-10

    /#?? ??"??"????????????"???"??"?????????"????????"???????"????"?????"???????"??"???????"?????" ????"?????????"?-??"???"??"??????????"?????????????" ?????????????"???????"??"???"?-?-???""5??????"???"?-??????"???"6&/??"?????" Chapter 2 ???" ?/???????????" 6?????????????" 2????" ???" *? ??" ????" ?" ?$???????" 6?????????????" 5???????" " " 6???" ????" ??????" ???" ???" ???????????" ??" ???????????" ?????" ??" ???" ?2...??????" ??-??" ??????????????" ???" ???" ???????" ???" ?2???????" ???" 2??????" ???" 0??-???" ?'???????????" &???" %?????????" ??? /?????????" 5????????" " +?" ????" ???" /21" ??????" ???" 6...

  7. Climate Action Champions: Metropolitan Washington Council of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    (COG) and its member governments are pioneering efforts to address and prepare for climate change and are recognized leaders in that regard. In 2008, the COG Board of...

  8. The Vertical Turn: Topographies of Metropolitan Modernism

    E-Print Network [OSTI]

    Haacke, Paul

    2011-01-01

    than the towers of the Brooklyn Bridge, which inspired poetsby jumping off the Brooklyn Bridge. And so, just as SeptimusLooking at the Brooklyn Bridge against the Manhattan

  9. Transportation 2035 Longview Metropolitan Transportation Plan 

    E-Print Network [OSTI]

    Longview Metropolitan Planning Organization

    2009-11-12

    -f Annual Household Income, 2002 II-g Annual Household Income, 2035 III-a Wetlands IV-a FM 2275/George Richey Road Alignment Alternatives IV-b North East Texas Regional Mobility Authority, Toll 49 IV-c Major Streets & Highways VI-a Truck... I-a MPO Boundary II-a 2002 Base Yr. Volume/Capacity II-b Residential Permits & Demolitions, 1999 - 2009 II-c Commercial Permits & Demolitions, 1999 - 2009 II-d Population Growth, 2002 to 2035 II-e Employment Growth, 2002 to 2035 II...

  10. Metropolitan Community College (Missouri-all locations)

    E-Print Network [OSTI]

    3 ART 103 3D Computer Animation 3 ART 105 Digital Sketchbook 3 ART 170 Ceramics 3 ART 220 Painting 3 ART 244 Digital Photography 3 ART 254 Silk Screen Printing 3 ART 255 Silk Screen Printing 2 3 ART 256 Silk Screen Printing 3 3 ART 261 Graphic Design 3 3 ART 270 Illustration 3 ART 102 Computers in Design

  11. Metropolitan Community College (Missouri-all locations)

    E-Print Network [OSTI]

    ART 261 Graphic Design 3 3 ART 270 Illustration 3 ART 102 Computers in Design 3 ART 103 3D Computer Photography 3 ART 254 Silk Screen Printing 3 ART 255 Silk Screen Printing 2 3 ART 256 Silk Screen Printing 3 3

  12. Metropolitan Community College (Missouri-all locations)

    E-Print Network [OSTI]

    ART 261 Graphic Design 3 3 ART 270 Illustration 3 ART 102 Computers in Design 3 ART 103 3D Computer Photography 3 ART 254 Silk Screen Printing 3 ART 255 Silk Screen Printing 2 3 ART 256 Silk Screen Printing 3 3 Sculpture 3 ART 139 Photography 3 ART 142 Fiber 3 ART 254 Silk Screen Printing 3 ART 141 Beginning Jewelry

  13. Metropolitan Community College (Missouri-all locations)

    E-Print Network [OSTI]

    270 Illustration 3 ART 102 Computers in Design 3 ART 103 3D Computer Animation 3 ART 105 Digital 242 Photography 3 3 ART 243 Photography 4 3 ART 244 Digital Photography 3 ART 254 Silk Screen Printing 3 ART 255 Silk Screen Printing 2 3 ART 256 Silk Screen Printing 3 3 ART 261 Graphic Design 3 3 ART

  14. The Vertical Turn: Topographies of Metropolitan Modernism

    E-Print Network [OSTI]

    Haacke, Paul

    2011-01-01

    comparable to that of Albert Camus, whose travel essay “Lestheir irony. 93 Camus, Albert. “Hope and Absurdity” in Thethat, Sartre, 128-9 Camus, Albert. "Les pluies de New York,"

  15. Metropolitan Community College (Missouri-all locations)

    E-Print Network [OSTI]

    in advanced art or design studio courses. Students complete Drawing I, Drawing II, Art Concepts & Practice HWC 205 Western Civilization 2 3 HIST 134 Modern Western Civilization 3 HUMN 134 Modern Western I 5 CHEM 135 Chemistry 2 5 CHEM 112 General College Chemistry II 5 PHSX 114 College Physics 5 PHYS

  16. Metropolitan Transportation Plan 2010-2035 

    E-Print Network [OSTI]

    Wichita Falls Metropolitan Planning Organization

    2010-01-27

    ,212 by 2035. The greatest amount of the population growth will occur in southwest portion of the city just north of Lake Wichita. Growth will occur west of Interstate Highway 44 in the north portion of the region in close proximity to Sheppard AFB... 171 LEBANON WELLINGT ON KEMP JEFFERSON AVENUE K SOUTHWEST LINCOLN 9TH PETROLIA BEVERL Y US 82 US 287 US 287 IH 44 US 287 KELL KELL US 287 Sheppard AFB Lake Wichita Pleasant Valley Lakeside City Wichita Falls MTP 2005 Congestion Map LOS D LOS C LOS B...

  17. Metropolitan Community College (Missouri-all locations)

    E-Print Network [OSTI]

    130 Varieties of Human Exper/Comparative Societies 3 f. MATH 101 College Algebra or MATH 104 ENGL 264 US Latino and Latina Literature 3 GE3H MATHEMATICS (2 courses) Core MATH 101 College Algebra 3 MATH 120R College Algebra with Review 5 GE12 OR MATH 120 Algebra 3 GE12 MATH 104 Precalculus

  18. Metropolitan Community College (Missouri-all locations)

    E-Print Network [OSTI]

    Equations 3 MATH 230 Differential Equations 4 MATH 290 Elementary Linear Algebra 2 No equivalent ECONOMICS Equations 4 MATH 290 Elementary Linear Algebra 2 No equivalent ECONOMICS & electives Core Choose One: ECON MATH 101 College Algebra 3 MATH 120R College Algebra with Review 5 GE12 OR MATH 120 Algebra 3 MATH 104

  19. Metropolitan Community College (Missouri-all locations)

    E-Print Network [OSTI]

    /Comparative Societies 3 f. MATH 101 College Algebra or MATH 104 Precalculus 3 g. GEOL 104 & 105 Physical Geography 5 h 101 College Algebra 3 MATH 120R College Algebra with Review 5 GE12 OR MATH 120 Algebra 3 GE12 MATH 104. 2nd Math, either MATH 115 or MATH 365 3 Unified Early Childhood Education Requirements: KU Course

  20. Metropolitan Community College (Missouri-all locations)

    E-Print Network [OSTI]

    122 Calculus 2 5 MATH 210 Analytic Geometry & Calc. 3 5 MATH 223 Linear Algebra 3 No equivalent MATH 290 Elementary Linear Algebra 2 No equivalent MATH 220 Differential Equations 3 MATH 230 Differential Calc 2 5 GE12 MATH 122 Calculus 2 5 MATH 210 Analytic Geometry & Calc. 3 5 MATH 223 Linear Algebra 3

  1. Metropolitan Community College (Missouri-all locations)

    E-Print Network [OSTI]

    Algebra or MATH 104 Precalculus 3 g. BIOL 100 & 102 Principals of Biology (for Math Concentration) 5 h. 2 GE21 MATHEMATICS (3 courses) Core MATH 101 College Algebra 3 MATH 120R College Algebra with Review 5 GE12 MATH 120 Algebra 3 GE12 MATH 125 Calculus 4 MATH 180 Analytic Geometry & Calc. 5 GE12 MATH S365

  2. Lafayette Metropolitan Planning Organization 2030 Transportation Plan 

    E-Print Network [OSTI]

    Lafayette Metropolitan Planning Organization

    2010-10-31

    ............................................................................................................ v GLOSSARY...................................................................................................................... vi CHAPTER 1: INTRODUCTION .................................................................................... 1 1.0... ...................................................................................................................... 70 APPENDIX 1.0: CODING GUIDE .......................................................................................... 70 APPENDIX 1.1: DEMOGRAPHIC VARIABLES .................................................................. 70 APPENDIX 1...

  3. Baton Rouge Metropolitan Transportation Plan Update 

    E-Print Network [OSTI]

    Capital Region Planning Commission

    2007-01-01

    ....................................................................................48 FIGURE 20 ? SAMPLE MODEL SETUP INTERFACE .......................................................50 FIGURE 21 ? MODE CHOICE MODEL ESTIMATED NESTING STRUCTURE ........................................................58 FIGURE 22 ? FEEDBACK... Baton Rouge, LA xiii December 2007 S. No Project Number Parish Name (Location) Improvement Total Cost (000) Funding Source 1 742-17-MAP8 EBR Transfer CMAQ Funds to STPHAZ City's Share of M.A.P. 1,750 CM 2 077-02-0019 ASC LA 73 (LA 74 - LA...

  4. Metropolitan Community College (Missouri-all locations)

    E-Print Network [OSTI]

    - Choose one Core ECON 142 Princ of Microeconomics 3 ECON 210 Economics 3 GE3S ECON 144 Princ Prn Molecular/Cellular 5 No equivalent GE3N BIOL 152 Princ of Organismal Biology 5 No equivalent GE3N

  5. The Metropolitan Water District of Southern California

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield Municipal Gas &SCE- Non-ResidentialAlliantPGE andOffice -EnergyEnergyManagement of theManager

  6. Metropolitan Edison Co (Pennsylvania) | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoop Inc Jump to: navigation,Mereg GmbH Jump to: navigation, searchMetalcoEdison Co

  7. Mercury Chamber NF-IDS Meeting

    E-Print Network [OSTI]

    McDonald, Kirk

    windows (upstream and downstream) ­ Shell cooling? #12;4 Managed by UT-Battelle for the U.S. Department Upstream View Downstream View #12;6 Managed by UT-Battelle for the U.S. Department of Energy Mercury Isometrics Downstream Beam Window Drainage Notch Overflow & Maintenance Drains Nozzle, Beam Pipe, Vents

  8. Solid Target Studies for NF Rob Edgecock

    E-Print Network [OSTI]

    McDonald, Kirk

    . Proposed lubricant (coating): WS2 Demonstrated to work to ~1300oC in vacuum. #12;Target Change #12;Target Calculations and Optimisation. John 4. Chain Design Optimisation ­ roller chain or alternative. David Consult

  9. NF Energy Saving Corp | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QAsource History ViewMayo, Maryland: EnergyInformationOliver,Minnesota:EnergyNARI JumpNEXTGen Syndicate LLC

  10. IDS NF Target StudiesIDS-NF Target Studies H. Kirk (BNL)( )

    E-Print Network [OSTI]

    McDonald, Kirk

    20 40 60 80 100 Proton Kinetic Energy, GeV #12;Meson Production EfficiencyMeson Production Efficiency

  11. CSOnet: A Metropolitan Scale Wireless Sensor-Actuator Network

    E-Print Network [OSTI]

    Lemmon, Michael

    that monitors and controls the frequency of combined sewer overflow (CSO) events in city sewer systems. CSO and Purdue University) agen- cies. The WSAN is being built to control the frequency of combined-sewer is described in section V. II. COMBINED-SEWER OVERFLOW PROBLEM More than 700 cities in the U.S. have sewer

  12. New Orleans Urbanized Area Metropolitan Transportation Plan FY 2032 

    E-Print Network [OSTI]

    New Orleans Urbanized Area Regional Planning Commission

    2007-06-12

    Road Corridor---------------------------------------------------------------------------------- 52 Earhart Corridor--------------------------------------------------------------------------------------- 53 Causeway Boulevard Widening...

  13. Built Landscapes of Metropolitan Regions: An International Typology

    E-Print Network [OSTI]

    Wheeler, Stephen M

    2015-01-01

    can infl uence the urban heat island effect. Journal of thegas emissions, and urban heat island effects, Keywords:Cervero, 2010), urban heat island effects (e.g. , Stone &

  14. Tulsa Metropolitan Area Destination 2030 Long Range Transportation Plan 

    E-Print Network [OSTI]

    Indian Nations Council of Governments

    2005-01-01

    , Osage, Rogers, Tulsa, and Wagoner counties. INCOG?s purpose is to promote economy and ef?ciency in government by providing a forum for regional cooperation and by supporting members with planning, development, management, research, and coordination... www.incog.org MAILING ADDRESS 201 W. 5th Street Suite 600 Tulsa, OK 74103-4236 The 1,200 square-mile Tulsa Transportation Management Area (TMA) is comprised of Tulsa County and portions of Creek, Osage, Rogers, and Wagoner counties. The area...

  15. Cultural Benefits from Metropolitan River Recreation -- San Antonio Prototype 

    E-Print Network [OSTI]

    Gunn, C. A.; Reed, D. J.; Couch, R. E.

    1972-01-01

    This study analyzes the response to an outstanding design and development of a park-business complex along a natural river in the heart of a major city, The San Antonio River Walk. The research includes both those who visit and those who control...

  16. Green Roofs in the New York Metropolitan Region

    E-Print Network [OSTI]

    University of New York and Regional Plan Association Stuart Gaffin, Center for Climate Systems Research Hodges, Hunter College, City University of New York Paul Mankiewicz, Gaia Institute Franco Montalto, eDesign and Graduate School of Architecture, Planning, and Preservation, Columbia University Cynthia Rosenzweig, NASA

  17. Migration Strategies towards All Optical Metropolitan Access Rings

    E-Print Network [OSTI]

    Aracil, Javier

    , in order to cope with the traffic increase and, most importantly, in order to reduce the CAPEX and OPEX reducing the CAPEX and OPEX of existing active technologies based on SDH/SONET rings and Ethernet star

  18. You give me fever : practical protection for metropolitan neuroses

    E-Print Network [OSTI]

    Case, Keith William

    2010-01-01

    The emergence of Swine Flu in the past six months has once again heightened the world's fears of a coming flu pandemic. Although H1N1 is only slightly more pathogenic than the common seasonal flu, which kills approximately ...

  19. Texarkana Urban Transportation Study 2035 Metropolitan Transportation Plan 

    E-Print Network [OSTI]

    Texarkana Metropolitan Planning Organization

    2009-10-01

    And Local Resource Agencies 1-7 Inclusion of Indian Tribes in the Transportation Process 1-8 2 SOCIO-ECONOMIC DATA 5 ROADS & BRIDGES Population Data 2-1 Road Performance 5-1 Housing Data 2... to increased motor fuels taxes or alternative revenue sources 4. Decaying infrastructure 5. Increasing demand for new infrastructure and access to alternative modes Starting with the Intermodal Surface Transportation Act of 1991 (ISTEA), the regulatory...

  20. Farmington Metropolitan Planning Organization 2010-2035 Transportation Plan 

    E-Print Network [OSTI]

    Farmington Metropoliatan Planning Organization

    2010-04-15

    ?bike?lanesfrom?Murray?to?Miler? Ruth?Lane?Blomfield? New?bike?lanesfrom?US?64?to?West?Blanco?Blvd?NM?516?&?US?50? Aztec? Wide?shoulders?marked?as?bike?routeswithin?the?City?Limits?Ash?St.? Aztec? New?bike?lanesfrom?Llano?to?NM?516? Chaco?St.? Aztec? New?bike?lanesfrom?NM?516?to...?Ash?St.?Rio?Grande?Ave? Aztec? New?bike?lanesfrom?Blanco?to?US?550?US?64? Farmington? New?sidewalksfrom?Malta?to?Hilside?(north?side?only)? San?Juan?Blvd? Farmington? New?sidewalksfrom?Butler?to?Main?St.?West?Blanco?Blvd? Blomfield? New?sidewalksfrom?US?50?to...

  1. After Exodus : re-occupation of the metropolitan wall

    E-Print Network [OSTI]

    Allison, Jordan Lloyd Norman

    2012-01-01

    The title "Exodus alludes to a restricted exclave encircled by a forbidding wall -- effect, a prison on the scale of a metropolis, and one in which people sought refuge voluntarily. Over the past forty years, similar walls ...

  2. The 2005 - 2030 Harlingen-San Benito Metropolitan Transportation Plan 

    E-Print Network [OSTI]

    Harlingen-San Benito Metropolitan Planning Organization

    2004-12-29

    . Construct Additional Rail and Complete Rail Realignments E. Construct Intercity Loops 5.14 Future Freeway Traffic Management and Operations Team??pg. 76 5.15 Future Mobility and Arterial Congestion Team???????pg. 77 5.16 Goals to Meet Transportation... of Mobility Level of Accessibility System Relationships Interstate or Freeway Connects urban and rural service, connects urban sub regions, connects urban areas. There is no direct land access. Used for long trips at high speeds...

  3. Lawton Metropolitan Planning Organization 2030 Long Range Transportation Plan 

    E-Print Network [OSTI]

    Lawton Metropolitan Planning Organization

    2008-01-01

    Uranium IAEA International Atomic Energy Agency ITDB IAEA Illicit Trafficking Database Li Lithium MCNP Monte Carlo N-Particle NNSA National Nuclear Security Agency/Administration NSC Nuclear Science Center PNNL Pacific Northwest... by the National Nuclear Security Administration (NNSA) to deter, detect, and interdict illicit trafficking of nuclear and radioactive materials across international borders and by maritime shipping. SLD aims to equip 30 countries with portal detection equipment...

  4. Planning for mitigating climate change risk to metropolitan areas (USA) 

    E-Print Network [OSTI]

    Grover, Himanshu

    2009-06-02

    the growing urban areas in the world. The program coordinated the CO2 reduction efforts of 14 municipalities in Canada, the United States, and Europe. The program proved remarkably successful, with municipalities achieving both significant reductions in CO2... compensation (Rayner et al., 1999). The approach places the responsibility of remediation on the communities that have caused the damage by overuse of the common pool resources. The CCP program itself aims to enlist the higher polluting cities to commit...

  5. Performance Measurement in Small Texas Metropolitan Planning Organizations 

    E-Print Network [OSTI]

    Moore, Devin 1984-

    2012-10-16

    Performance measurement has grown in importance within transportation agencies due to decreased and stipulated funding and federal focus on system performance. A shift has occurred in how transportation planning and decision making historically took...

  6. Teito Tokyo: Empire, Modernity, and the Metropolitan Imagination

    E-Print Network [OSTI]

    Goddard, Timothy Unverzagt

    2013-01-01

    of East Asia (Keij?, Taipei, Dalian, and Shanghai). 141 Yisuch as Keij?, Taipei, Dalian, and Shanghai. As my study has

  7. Jonesboro Metropolitan Planning Organization 2030 Long Range Transportation Plan 

    E-Print Network [OSTI]

    Jonesboro Metropolitan Planning Organization

    2005-01-01

    ,500 1995 - 2003 -813 Oakdale Street ? Bittle Street 0291 15,000 1995 - 2003 -625 Oakmeadow Blvd. ? Franklin St. 0325 13,000 1995 - 2003 -125 Rains Street ? Perkin Street 0326 11,000 1995 - 2003 -125 Madison Street ? Haven Street 0244 10,000 1995 - 2003.... Land Use 3-2 D. Traffic Analysis and Forecast 3-2 Chapter 4: Goals and Priorities 4-1 A. Why a Transportation Plan 4-1 B. Goals and Priorities 4-1 Chapter 5: Streets and Highways 5-1 Introduction 5-1 Goals and Objectives 5...

  8. Alternative Fuels Data Center: Metropolitan Utilities District Fuels

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 OutreachProductswsicloudwsiclouddenDVA N C E D B L O O D S TA IMaryland Conserves Fuel With HybridVehicles With

  9. Los Angeles County Metropolitan Transportation Authority Metro | Open

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QAsource History View NewTexas:Montezuma, Arizona:Oregon: EnergyLloyd, NewBranchLongweiLos Alamos CountyAltosEnergy

  10. Metropolitan Water District of S CA | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoop Inc Jump to: navigation,Mereg GmbH Jump to: navigation, searchMetalcoEdison

  11. Metropolitan Edison Company SEF Grants (FirstEnergy Territory) | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURING OFFICESpecial ReportProposal toDepartment of EnergyDepartment ofFYFYgas

  12. Metropolitan Edison Company SEF Loans (FirstEnergy Territory) | Department

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i nAand DOE Safetyof Methane Hydrate Program Annual Report to

  13. Chicago Metropolitan Agency for Planning Data Dashboard | Department of

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p a lCaribElectricSouthApplying2-2002 July 2002

  14. Chicago Metropolitan Agency for Planning Summary of Reported Data |

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p a lCaribElectricSouthApplying2-2002 July 2002Department of Energy

  15. Climate Action Champions: Metropolitan Washington Council of Governments,

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergy A plug-in electric vehicle (PEV) chargingWASHINGTON, DCThe City of Dubuque,DC, MD,

  16. Energy Management Program atEnergy Management Program at Metropolitan Water District ofMetropolitan Water District of

    E-Print Network [OSTI]

    Keller, Arturo A.

    reconfiguration ­ 50% reduction in energy use ­ $1+ million annual energy savings, $500,000 rebate (SCE) 45 Station reconfiguration ­ 50% reduction in energy use ­ $1+ million annual energy savings, $500,000 rebate

  17. NF kappa B expression and matrix metalloproteinase activity in hypertension

    E-Print Network [OSTI]

    Wu, Kwan-I

    2009-01-01

    14% (Fig. 3-1), and in hypothalamus region of brain by 22% (?B expression level in hypothalamus region of the brain. Forp65 subunit in the hypothalamus. N=4 rats for each group. *p

  18. N_f=2+1 flavour equation of state

    E-Print Network [OSTI]

    Szabolcs Borsanyi; Gergely Endrodi; Zoltan Fodor; Antal Jakovac; Sandor D. Katz; Stefan Krieg; Claudia Ratti; Kalman K. Szabo

    2010-11-18

    We conclude our investigation on the QCD equation of state (EoS) with 2+1 staggered flavors and one-link stout improvement. We extend our previous study [JHEP 0601:089 (2006)] by choosing even finer lattices. These new results [for details see arXiv:1007.2580] support our earlier findings. Lattices with N_t=6,8 and 10 are used, and the continuum limit is approached by checking the results at N_t=12. A Symanzik improved gauge and a stout-link improved staggered fermion action is taken; the light and strange quark masses are set to their physical values. Various observables are calculated in the temperature (T) interval of 100 to 1000~MeV. We compare our data to the equation of state obtained by the "hotQCD" collaboration.

  19. NF 3 , the greenhouse gas missing from Kyoto

    E-Print Network [OSTI]

    Prather, Michael J; Hsu, Juno

    2008-01-01

    of the world’s largest coal-fired power plants. If released,the world’s largest coal-fired power stations (e.g. , 25 toO b CH 4b CO 2b 3600 MW Coal-Fired Plants Scherer (Georgia,

  20. ARM - VAP Product - aerich1nf1turn

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach HomeA Better AnodeThe Influence ofrlprofasr1ferrProductsabrfcabrfcprecip Documentation abrfc :

  1. ARM - VAP Product - aerich2nf1turn

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach HomeA Better AnodeThe Influence ofrlprofasr1ferrProductsabrfcabrfcprecip Documentation abrfc

  2. CMRR-NF Supplemental EIS Scoping Comments | National Nuclear Security

    National Nuclear Security Administration (NNSA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield Municipal Gas &SCE-SessionsSouthReporteeo | National Nucleara minNuclear SecurityREQUIREMENTS

  3. Functional diversity in amphipods revealed by stable isotopes in an eelgrass ecosystem

    E-Print Network [OSTI]

    Farlin, JP; Lewis, LS; Anderson, TW; Lai, CT

    2010-01-01

    Diego City Metropolitan Waste Water District for assistanceCity Metropolitan Waste Water District. Sample preparation

  4. Decision Analysis on Water Resources Planning and Management for an Arid Metropolitan Center in West Texas 

    E-Print Network [OSTI]

    Shih, C. S.; Dean, J. H.

    1973-01-01

    The demand by consumers for public-owned low-priced natural resources is essentially insatiable. When natural resources become scarce the public is agonized by the problem of making an optimum choice or choices from feasible ...

  5. An Assessment of Air Service Accessibility in U.S. Metropolitan Regions, 2007-2012

    E-Print Network [OSTI]

    Wittman, M.D.

    2014-05-20

    Regional accessibility to air transportation is often of interest to airport executives, politicians, and the general public due to the positive economic impacts of frequent commercial airline service. However, measuring ...

  6. Analysis of The Housing Market in the Metropolitan Areas in the United States 

    E-Print Network [OSTI]

    Li, Yarui

    2013-12-04

    The housing market plays a significant role in shaping the economic and social well-being of U.S. households. It helps spur U.S. economic growth when house prices rise, and drags the economic growth when house prices drop. In this dissertation...

  7. On Comparing Two Social Science Traditions: The "Metropolitan" Question in France and in the US

    E-Print Network [OSTI]

    ghorra-gobin, cynthia

    2015-01-01

    given social and spatial inequalities among municipalitiesin the French context inequalities are mainly dealt into the white population. Inequality among municipalities

  8. Jefferson Orange Hardin Regional Transportation Study 2007 Metropolitan Transportation Plan - 2030 

    E-Print Network [OSTI]

    South East Texas Regional Planning Commission

    2007-04-12

    .9 shows the relationship between the rail group staff, the Austin office and Central Division management, and the client and market leadership. Rail Market Sector Leader Austin Office Client Service Leaders Rail Group Central Division BNSF...

  9. An Analysis of the Impacts of British Transport Reforms on Transit Integration in the Metropolitan Areas

    E-Print Network [OSTI]

    Rivasplata, Charles Richard

    2006-01-01

    British Transport Commission (BTC), 1963. The Reshaping ofroutes throughout Britain (BTC 1963), it had little direct

  10. Modeling the Dynamics of Desakota Regions: Global - Local Nexus in the Taipei Metropolitan Area 

    E-Print Network [OSTI]

    Wu, Bing-Sheng

    2010-10-12

    in 1991, focuses on how internal domestic and local forces drive the specific rural-urban transformation in Asia. However, the McGee-Ginsburg model does not emphasize the importance of globalization on Asian urbanization. To fill the gap, this study...

  11. An Analysis of the Impacts of British Transport Reforms on Transit Integration in the Metropolitan Areas

    E-Print Network [OSTI]

    Rivasplata, Charles Richard

    2006-01-01

    Transport Policy and Sustainable Mobility, London: Spon.sustainable environment. It is through the development of a comprehensive set of mobility

  12. Chemical evolution of volatile organic compounds in the outflow of the Mexico City Metropolitan area

    E-Print Network [OSTI]

    2010-01-01

    MEX 1 . Compound C-130 T0 T1 G1 Ethane Propane i-Butanen-Butane i-Pentane n-Pentane n-Hexane n-Heptane n-OctaneEthyne Propane Propene i-Butane n-Butane 1-Butene + i-Butene

  13. Real-time Air Quality Monitoring Through Mobile Sensing in Metropolitan Areas

    E-Print Network [OSTI]

    Iftode, Liviu

    . General Terms Measurement, Design, Experimentation, Human Factors. Keywords Air Quality, Pollution, Urban levels in the urban and suburban settings. According to the US EPA [3], the six common air pollutants. These are called the criteria pollutants and thus are required to be measured to tell us how healthy the air

  14. Urban growth pattern and sustainable development: a comparative study of municipalities in the Seoul Metropolitan Region 

    E-Print Network [OSTI]

    Paek, Seunggeun

    2006-10-30

    sustainability in 31 study areas for the years 1990, 1995 and 2000. Data for this study were drawn from the 1990-2000 censuses and local government publications. Statistical methods such as t-test, analysis of variance and factor analysis were used to answer...

  15. METRA (Metropolitan Rail Corporation) Posting Period Chicago May 23 June 6, 2014

    E-Print Network [OSTI]

    Bustamante, Fabián E.

    including design of relay interlocking, application of essential signaling equipment such as Microlok, VPI include the use of Ladder, Relay and Boolean. § Project management experience is preferred. § Must have to a physical examination/drug test and background check to verify information regarding education, employment

  16. Sustainable metropolitan mobility and public-private partnerships : a highway to institutional reform?

    E-Print Network [OSTI]

    Grillo, Christopher C. (Christopher Charles)

    2011-01-01

    The "sustainability" literature generally acknowledges a critical role for transportation infrastructure planning, finance, investment, design, construction, operation, and management for addressing the long-term viability ...

  17. Chemical evolution of volatile organic compounds in the outflow of the Mexico City Metropolitan area

    E-Print Network [OSTI]

    2010-01-01

    Butene cis-2-Butene 1,3-Butadiene 1-Pentene trans-2-Pentenei-Pentane n-Pentane 1,3-Butadiene 1-Pentene Isoprene trans-i-Pentane n-Pentane 1,3-Butadiene 1-Pentene Isoprene trans-

  18. An Analysis of the Impacts of British Transport Reforms on Transit Integration in the Metropolitan Areas

    E-Print Network [OSTI]

    Rivasplata, Charles Richard

    2006-01-01

    dares – the London experience, Transportation Planning anddecisions, Transportation 27: 243-267. London Transport (transportation, Mass Transit (November). Transport for London (

  19. Emission Testing of Washington Metropolitan Area Transit Authority (WMATA) Natural Gas and Diesel Transit Buses

    SciTech Connect (OSTI)

    Melendez, M.; Taylor, J.; Wayne, W. S.; Smith, D.; Zuboy, J.

    2005-12-01

    An evaluation of emissions of natural gas and diesel buses operated by the Washington Metro Area Transit Authority.

  20. Analysis of a Mixed-Use Urban WiFi Network: When Metropolitan becomes Neapolitan

    E-Print Network [OSTI]

    Snoeren, Alex

    spectrum. We study the usage of the Google WiFi network de- ployed in Mountain View, California, and find that copies are not made or distributed for profit or commercial advantage and that copies bear this notice- able outdoor wireless Internet service deployed in Mountain View, California, consisting of over 500

  1. Technology and policy options for reducing industrial air pollutants in the Mexico City Metropolitan Area

    E-Print Network [OSTI]

    Vijay, Samudra, 1968-

    2005-01-01

    Technology plays an important role in dealing with air pollution and other environmental problems faced by developing and developed societies. This research examines if technological solutions alone, such as end-of-pipe ...

  2. Mobility 2030: The Metropolitan Transportation Plan for the Dallas-Fort Worth Area 2009 Amendment 

    E-Print Network [OSTI]

    North Central Texas Council of Governments

    2009-04-09

    are consistent with state and regional air quality improvement goals. Infrastructure Mainten. Management & Operations (ITS, TSM,TDM, Bike/Ped) Rail & Bus HOV/Managed Lanes Freeway/Tollway & Arterial Mobility Plan = Intermodal Planning Efforts System..., Paratransit Capital $1.5 Regional Arterial System $3.4 Other Arterials $2.9 Freeway, Tollway, HOV, Managed System $32.8 *Costs are adjusted for ?total project cost? and ?year of expenditure? consistent with SAFETEA-LU planning requirements. ?Actual...

  3. Chemical evolution of volatile organic compounds in the outflow of the Mexico City Metropolitan area

    E-Print Network [OSTI]

    2010-01-01

    methanol, ethanol, formaldehyde, acetaldehyde), while higher VOCs are represented as a lumped alkane (BIGANE), lumped alkene (BIGENE) and lumped aromatic (

  4. Chemical evolution of volatile organic compounds in the outflow of the Mexico City Metropolitan area

    E-Print Network [OSTI]

    2010-01-01

    C-130 T0 T1 G1 Ethane Propane i-Butane n-Butane i-Pentane n-ppbv) Ethane Ethene Ethyne Propane Propene i-Butane n-Butanee.g. , ethane, ethene, propane, propane, methanol, ethanol,

  5. Intra-metropolitan location of foreign direct investment in Wuhan, China: Institution, urban structure, and accessibility

    E-Print Network [OSTI]

    Wei, Yehua Dennis

    model with geographically weighted regression, we examine the effects of institution and urban structure-temporal patterns of FDI within Wuhan. It integrates a lo- gistic model with geographically weighted regressions on the Wuhan Economic and Technological Development Zone, a national development zone. Combining the logistic

  6. The Origins of Metropolitan Transportation Planning in Travel Demand Forecasting, 1944-1962

    E-Print Network [OSTI]

    Deutsch, Cheryl

    2013-01-01

    J. (1955). The law of retail gravitation applied to trafficas “Reilly’s Law of Retail Gravitation. ” Concepts like

  7. Green optical network design : power optimization of wide area and metropolitan area networks

    E-Print Network [OSTI]

    Lin, Katherine Xiaoyan

    2011-01-01

    Advancements in technology are fueling huge growth in network traffic capacity. Demand for low cost, reliable, and high bitrate transmissions grows 40-110% internationally every year. To date, most research has focused on ...

  8. ManchesterMetropolitanUniversityCareers&EmployabilityService How to...plan time out

    E-Print Network [OSTI]

    of the options you are considering whilst you take stock of your short and long term career objectives. How graduation www.mmu.ac.uk/careers Oct 2012 It is increasingly common for graduates to consider taking time out taking a year out to build up your employability skills You need to explore your options before making

  9. Fee Assessment Information for Overseas Applicants RIBM Graduate School, Manchester Metropolitan University

    E-Print Network [OSTI]

    and Liechtenstein. c) Refugee*, or the spouse or child of a refugee, (provided refugee status has been granted

  10. Fee Assessment Information for Overseas Applicants RIBM Graduate School, Manchester Metropolitan University

    E-Print Network [OSTI]

    and Liechtenstein. c) Refugee*, or the spouse or child of a refugee, (provided refugee status has been granted; if no, please continue) 4) Do you have full refugee status or Exceptional Leave to Enter/ YES NO Remain, please go to 10 and enclose a copy of the letter from the immigration authorities in which refugee status

  11. Spatial Politics in Metropolitan Miami: Cuban American Empowerment, Municipal Incorporations, and Cultural Production

    E-Print Network [OSTI]

    Burga, Hector Fernando

    2013-01-01

    initiated Miami’s brand of pop art based on a colorful happyan artist in the tradition of pop art himself, he explicitlyan unmemorable pop-up event space. Over the years, Art Basel

  12. An Analysis of the Impacts of British Transport Reforms on Transit Integration in the Metropolitan Areas

    E-Print Network [OSTI]

    Rivasplata, Charles Richard

    2006-01-01

    contrast to many other cities with the smart card system ofthe three case cities. Fare integration: transit smart cardsonly city in the country to have introduced a transit smart

  13. Planners and the Pork Barrel: Metropolitan Engagement in and Resistance to Congressional Transportation Earmarking

    E-Print Network [OSTI]

    Sciara, Gian-Claudia

    2009-01-01

    12 A Drive Down Coconutan interstate connection at Coconut Road. Yet, the region’svoted twice against linking Coconut Road to the interstate.

  14. A DESCRIPTIVE STUDY OF PUBLIC HIGH SCHOOL FRESHMEN TRANSITION PROGRAMS IN THE KANSAS CITY METROPOLITAN AREA

    E-Print Network [OSTI]

    Biermann, Brian Richard

    2010-07-05

    Transitioning into high school can be exciting but also challenging for some students. To combat some of the common pitfalls incoming freshmen face, schools are developing freshmen induction programs. This research was a descriptive study of twenty...

  15. Chemical evolution of volatile organic compounds in the outflow of the Mexico City Metropolitan area

    E-Print Network [OSTI]

    2010-01-01

    results in bar graphs and pie charts. The bar graphs show03:00 p.m. Shown in the first pie chart to the right of eachof each bar graph is a pie chart showing the breakdown of

  16. Final Independent External Peer Review Report Fargo-Moorhead Metropolitan Flood Risk

    E-Print Network [OSTI]

    US Army Corps of Engineers

    feet in 51 of the past 107 years, and every year from 1993 through 2009. The study area is between in Minnesota also cross the study area. The primary problem in the study area is a high risk of flood damage, Canada. The drainage area of the Red River of the North above the U.S. Geological Survey gauging station

  17. Economic Fundamentals in Local Housing Markets: Evidence from U.S. Metropolitan Regions

    E-Print Network [OSTI]

    Hwang, Min; Quigley, John M.

    2006-01-01

    patterns of house price development are depicted in Figurethe predicted housing price developments from the same model

  18. Economic fundamentals in local housing markets: Evidence from US metropolitan regions

    E-Print Network [OSTI]

    Hwang, Min; Quigley, John M.

    2006-01-01

    patterns of house price development are To accomplish this,the predicted housing price developments from the same model

  19. Formation of semivolatile inorganic aerosols in the Mexico City Metropolitan Area during the MILAGRO campaign

    E-Print Network [OSTI]

    Karydis, V. A.

    One of the most challenging tasks for chemical transport models (CTMs) is the prediction of the formation and partitioning of the major semi-volatile inorganic aerosol components (nitrate, chloride, ammonium) between the ...

  20. Facebook, Writing and Language Learner Variables at a Large Metropolitan Community College

    E-Print Network [OSTI]

    Dixon, Gregory A.

    2011-05-31

    This study gathered information on student engagement with Facebook, and described non-native English speakers' (NNS) expectations and experience. This also assessed the relationship this technology has with writing efficacy and compared NNS...

  1. A policy story of continuity and change : reflections on the Obama Administration's Metropolitan Agenda

    E-Print Network [OSTI]

    Ullah, Athena Jade

    2011-01-01

    President Obama was sworn into office on January 20, 2009 and within the first month of his presidency, against a backdrop of staggering concerns about financial reform, energy efficiency, and the need to allocate $787 ...

  2. A Blueprint for Urban Sustainability: Integrating Sustainable Energy Practices into Metropolitan Planning, May 2004

    Office of Energy Efficiency and Renewable Energy (EERE)

    Blueprint to define sustainable energy planning as integrated energy & environmental planning to support community sustainability

  3. Planners and the Pork Barrel: Metropolitan Engagement in and Resistance to Congressional Transportation Earmarking

    E-Print Network [OSTI]

    Sciara, Gian-Claudia

    2009-01-01

    MPOs, and other eligible grantees to submit applications forTEA-21 requires that Job Access grantees be selected on aoutside these traditional grantees, such as minor local

  4. An ozone episode in the Philadelphia metropolitan area Lawrence I. Kleinman,1

    E-Print Network [OSTI]

    , winds were nearly stagnant, allowing local emissions to accumulate. In contrast to typical O3 episodes urban areas. High O3 was also observed in a less likely region near the Delaware-Pennsylvania border by 60­80 ppb. Photochemical model calculations indicate O3 production rates in excess of 20 ppb hÀ1

  5. A comparative study of ozone production in five U.S. metropolitan areas

    E-Print Network [OSTI]

    ) are calculated using observed concentrations as inputs to a steady state box model. City to city comparisons are made to illustrate common features of urban photochemistry and features that are unique to specific. These conditions are infrequent, and aside from a common dependence on calm winds, reasons vary from city to city

  6. A plan for Metropolitan State Hospital : imagery as a therapy for an institution

    E-Print Network [OSTI]

    McMurrin, Sterling James

    1988-01-01

    This thesis is both text and illustration to describe the process of transforming a state mental institution from an outdated, outmoded, conventional hospital into a living community. The goal of the project is to develop ...

  7. DeKalb County/Metropolitan Atlanta Alternative Fuel and Advanced Technology

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum Based| Department8, 20153Daniel Boff About UsWorkDavid

  8. DeKalb County/Metropolitan Atlanta Alternative Fuel and Advanced Technology

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum Based| Department8, 20153Daniel Boff About UsWorkDavidVehicle Project |

  9. DeKalb County/Metropolitan Atlanta Alternative Fuel and Advanced Technology

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum Based| Department8, 20153Daniel Boff About UsWorkDavidVehicle Project |Vehicle

  10. Emission Testing of Washington Metropolitan Area Transit Authority (WMATA) Natural Gas and Diesel Transit Buses

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels Data Center Home PageBlender PumpVehiclesThe Heat Is onis3INTRODUCTIONEmission

  11. Washington Metropolitan Area Transit Authority: Biodiesel Fuel Comparison Final Data Report

    Alternative Fuels and Advanced Vehicles Data Center [Office of Energy Efficiency and Renewable Energy (EERE)]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels Data Center Home PageBlender PumpVehiclesThe HeatClean Cities

  12. Gradient flow and IR fixed point in SU(2) with Nf=8 flavors

    E-Print Network [OSTI]

    Viljami Leino; Tuomas Karavirta; Jarno Rantaharju; Teemu Rantalaiho; Kari Rummukainen; Joni M. Suorsa; Kimmo Tuominen

    2015-11-11

    We study the running of the coupling in SU(2) gauge theory with 8 massless fundamental representation fermion flavours, using the gradient flow method with the Schr\\"odinger functional boundary conditions. Gradient flow allows us to measure robust continuum limit for the step scaling function. The results show a clear indication of infrared fixed point consistent with perturbation theory.

  13. DEPOSITED POWER STUDIES FOR THE MC/NF TARGET STATION. Nicholas Souchlas (PBL)

    E-Print Network [OSTI]

    McDonald, Kirk

    . SHIELDING MATERIAL TO PROTECT SC COILS. SHIELDING VESSELS TO CONTAIN SHIELDING MATERIAL. SC SOLENOIDS CRYOGENIC COOLING COMPONENTS. LIQUID TARGET COLLECTING TANK (+ BEAM DUMP) AND REMOVAL CONFIGURATION. 2 15 55 #12;SHIELDING MATERIAL OPTIMIZATION (TYPE/QUANTITY) MINIMIZE DEMAND ON SC CRYOGENIC OPERATIONS. AVOID

  14. Effects of water chemistry on NF/RO membrane structure and performance

    E-Print Network [OSTI]

    Mo, Yibing

    2013-01-01

    1,4-dioxane…. ……………… 3.4. Water chemistry: Concentration,for EG………………………………………. 4.3.1. Effect of water chemistryon membrane water permeability … 4.3.1.1. Effect of ionic

  15. Materials Data on H11NF8 (SG:14) by Materials Project

    SciTech Connect (OSTI)

    Kristin Persson

    2014-11-02

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  16. Materials Data on H7NF4 (SG:161) by Materials Project

    SciTech Connect (OSTI)

    Kristin Persson

    2014-11-02

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  17. Materials Data on H8NF5 (SG:88) by Materials Project

    SciTech Connect (OSTI)

    Kristin Persson

    2014-11-02

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  18. Materials Data on TiH12(NF2)4 (SG:56) by Materials Project

    SciTech Connect (OSTI)

    Kristin Persson

    2014-11-02

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  19. Materials Data on H4NF (SG:186) by Materials Project

    SciTech Connect (OSTI)

    Kristin Persson

    2014-11-02

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  20. Thermal NF3 fluorination/oxidation of cobalt, yttrium, zirconium, and selected lanthanide oxides

    SciTech Connect (OSTI)

    Scheele, Randall D.; McNamara, Bruce K.; Casella, Andrew M.; Kozelisky, Anne E.; Neiner, Doinita

    2013-02-01

    This paper presents results of our continuing investigation on the use of nitrogen trifluoride as a fluorination or fluorination/oxidation agent for separating valuable constituents from used nuclear fuels by exploiting the different volatilities of the constituent fission product and actinide fluorides. This article focuses on fission products that do not have volatile fluorides or oxyfluorides at expected operations temperatures. Our thermodynamic calculations show that nitrogen trifluoride has the potential to completely fluorinate fission product oxides to their fluorides. Simultaneous thermogravimetric and differential thermal analyses show that the oxides of cobalt, zirconium, and the lanthanides are fluorinated but do not form volatile fluorides when treated with nitrogen trifluoride at temperatures up to 550°C. Our studies of gadolinium-doped commercial nuclear fuel indicate that nitrogen trifluoride can extract uranium from the non-volatile gadolinium.

  1. Can 3-D models explain the observed fractions of fossil and non-fossil carbon in and near Mexico City?

    SciTech Connect (OSTI)

    Hodzic, Alma; Jimenez, Jose L.; Prevot, A. S. H.; Szidat, S.; Fast, Jerome D.; Madronich, Sasha

    2010-11-25

    Abstract. A 3-D chemistry-transport model has been applied to the Mexico City metropolitan area to investigate the origin of elevated levels of non-fossil (NF) carbonaceous aerosols observed in this highly urbanized region. High time resolution measurements of the fine aerosol concentration and composition, and 12 or 24 h integrated 14C measurements of aerosol modern carbon have been performed in and near Mexico City during the March 2006 MILAGRO field experiment. The non-fossil carbon fraction (fNF), which is lower than the measured modern fraction (fM) due to the elevated 14C in the atmosphere caused by nuclear bomb testing, is estimated from the measured fM and the source-dependent information on modern carbon enrichment. The fNF contained in PM1 total carbon analyzed by a US team (f TC NF ) ranged from 0.37 to 0.67 at the downtown location, and from 0.50 to 0.86 at the suburban site. Substantially lower values (i.e. 0.24–0.49) were found for PM10 filters downtown by an independent set of measurements (Swiss team), which are inconsistent with the modeled and known differences between the size ranges, suggesting higher than expected uncertainties in the measurement techniques of 14C. An increase in the non-fossil organic carbon (OC) fraction (f OC NF ) by 0.10–0.15 was observed for both sets of filters during periods with enhanced wildfire activity in comparison to periods when fires were suppressed by rain, which is consistent with the wildfire impacts estimated with other methods. Model results show that the relatively high fraction of nonfossil carbon found in Mexico City seems to arise from the combination in about equal proportions of regional biogenic SOA, biomass burning POA and SOA, as well as non-fossil urban POA and SOA. Predicted spatial and temporal variations for f OC NF are similar to those in the measurements between the urban vs. suburban sites, and high-fire vs. low-fire periods. The absolute modeled values of f OC NF are consistent with the Swiss dataset but lower than the US dataset. Resolving the 14C measurement discrepancies is necessary for further progress in model evaluation. The model simulations that included secondary organic aerosol (SOA) formation from semi-volatile and intermediate volatility (S/IVOC) vapors showed improved closure for the total OA mass compared to simulations which only included SOA from VOCs, providing a more realistic basis to evaluate the fNF predictions. f OC NF urban sources of modern carbon are important in reducing or removing the difference in fNF between model and measurements, even though they are often neglected on the interpretation of 14C datasets. An underprediction of biomass burning POA by the model during some mornings also explains a part of the model-measurement differences. The fNF of urban POA and SOA precursors is an important parameter that needs to be better constrained by measurements. Performing faster ( 3 h) 14C measurements in future campaigns is critical to further progress in this area. To our knowledge this is the first time that radiocarbon measurements are used together with aerosol mass spectrometer (AMS) organic components to assess the performance of a regional model for organic aerosols.

  2. Examining the Impact of Spatial Development Patterns on Regional Heat Island Effect in Metropolitan Regions of the United States 

    E-Print Network [OSTI]

    Kim, Heeju

    2013-07-08

    The urban heat island effect is considered one of the main causes of global warming and is contributing to increasing temperatures in the urban United States. This phenomenon enhances the intensity of summer heat waves and the risk to public health...

  3. EV Community Readiness projects: Delaware Valley Regional Planning Commission (PA); Metropolitan Energy Information Center, Inc. (KS, MO)

    Broader source: Energy.gov [DOE]

    2013 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting

  4. Modeling urban growth and land use/land cover change in the Houston Metropolitan Area from 2002 - 2030 

    E-Print Network [OSTI]

    Oguz, Hakan

    2005-08-29

    for the period from 2002 to 2030 is predicted. Within SLEUTH, growth in the Houston CMSA is predominately "organic" with most growth occurring along the urban/rural fringe. Projected increases in urban area from 2002 to 2030 parallel projected increases...

  5. Onondaga County Department of Water Environment Protection: Process Optimization Saves Energy at Metropolitan Syracuse Wastewater Treatment Plant

    SciTech Connect (OSTI)

    2010-06-25

    This DOE Industrial Technologies Program spotlight describes how Onondaga County, New York, is saving nearly 3 million kWh and 270 million Btu annually at a wastewater treatment plant after replacing inefficient motors and upgrading pumps.

  6. The Metropolitan Accessibility Project The purpose of a transportation system is to meet people's needs and get them where they

    E-Print Network [OSTI]

    Papalambros, Panos

    's needs and get them where they want to go. Rapid mobility may seem like the best way to do this most efficiently, but planning transportation systems based on mobility alone can have the effect of spreading development out over wide areas, making destinations harder to reach and making the system less sustainable

  7. Access to jobs : transportation barriers faced by low-skilled autoless workers in U.S. metropolitan areas

    E-Print Network [OSTI]

    Kawabata, Mizuki, 1972-

    2002-01-01

    One of the major concerns in today's urban labor market is spatial mismatch, the geographic separation between jobs and workers. Although numerous studies examine spatial mismatch, most of them focus on inner-city minorities, ...

  8. MAKING DO: How Working Families in Seven U.S. Metropolitan Areas Trade Off Housing Costs and Commuting Times

    E-Print Network [OSTI]

    2006-01-01

    San Francisco Washington, D.C. /Baltimore Washington, D.C. /Baltimore Washington, D.C. /Baltimore Washington, D.C. /Baltimore XX XXX X Suburban

  9. Final report for "Characterization of Fine Particulate Matter (PM) and secondary PM Precursor Gases in the Mexico City Metropolitan Area"

    SciTech Connect (OSTI)

    Prof. Jose-Luis Jimenez

    2009-05-18

    The objectives of this funded project were (a) to further analyze the data collected by our group and collaborators in Mexico City during the MCMA-2003 field campaign, with the goal of further our understanding of aerosol sources and processes; and (b) to deploy several advanced instruments, including the newly developed high-resolution time-of-flight aerosol mass spectrometer (HR-ToF-AMS) and thermal-denuder (TD), during the MILAGRO/MAX-Mex/MCMA-2006 field campaign, and to analyze those data (together with the 2003 data) to provide additional insights on the formation and transformation of aerosols in the Mexico City area. These goals were addressed in collaboration with our project partners, MIT/Molina Center, and Aerodyne Research. Overall this project was very successful, resulting on 22+ journal papers including six “highly cited papers” and three papers that are the most cited in their respective journals (out of several thousand papers) since the year in which they were published. Multiple discoveries, such as the the underestimation of SOA in urban areas even for short photochemical ages, the demonstration that urban POA is of similar or higher volatility than urban SOA, and the first analysis of organic aerosol elemental composition in real-time have been recently published. Several dozen presentations at major US and international conferences and seminars also acknowledged this grant.

  10. Identification of Management and Planning Problems of Urban Water Resources in the Metropolitan Area of Greater San Antonio 

    E-Print Network [OSTI]

    Garner, K.; Shih, C. S.

    1971-01-01

    This interim report describes the research performed to date on Project A-017-TEX sponsored by the U. S. Department of Interior Office of Water Resources Research and the Texas A&M University Texas Water Resources ...

  11. Section 2: Landscapes of Capital - On Big Beaver Road: Detroit and the Diversity of American Metropolitan Landscapes

    E-Print Network [OSTI]

    Fishman, Robert

    2007-01-01

    Center near Ann Arbor, Detroit News, April 12, 2005, p. 8.on Southern Plant,” Detroit News, October 28, 2006, p. 3.Pro?le: Michigan 2005 (Detroit: Southeast Michigan Council

  12. From Cars to Casinos: Global Pasts and Local Futures in the Detroit-Windsor Transnational Metropolitan Area [book chapter

    E-Print Network [OSTI]

    Ryan, Brent D.

    Over the past twenty years the topics of globalization and the global city have come to dominate the intellectual dialogue on international planning and development. Related issues like poverty, neocolonialism, sustainability, ...

  13. No evidence for acid-catalyzed secondary organic aerosol formation in power plant plumes over metropolitan Atlanta, Georgia

    E-Print Network [OSTI]

    Weber, Rodney

    conducted in the summer of 2004. Five notable plumes of SO2, apparently from coal-fired power plants, wereNo evidence for acid-catalyzed secondary organic aerosol formation in power plant plumes over that secondary organic aerosol formation via heterogeneous acid-catalyzed reactions within power plant plumes

  14. Project identification and evaluation techniques for transportation infrastructure : assessing their role in metropolitan areas of developing countries

    E-Print Network [OSTI]

    Kumar, Vimal, S.M. Massachusetts Institute of Technology

    2009-01-01

    Project identification and evaluation of transportation infrastructure play a vital role in shaping and sustaining the forms of cities all over the world. These cities differ substantially in character and urban form and ...

  15. Spatial dimensions of workplaces and the effects on commuting: the dase of metropolitan Dallas-Fort Worth 

    E-Print Network [OSTI]

    Shin, Sangyoung

    2004-09-30

    -density suburban workplaces are associated with shorter vehicle travel times but more drive-alone trips. While major suburban centers attain some level of compact development in terms of local activity mix and regional accessibility, employees in these centers...

  16. A Modification to the NOAH LSM to Simulate Heat Mitigation Strategies in the New York City Metropolitan Area

    E-Print Network [OSTI]

    to simulating the urban environment with a mesocale model has been developed to identify efficient strategies temperature, moisture, and winds within an atmospheric model. This information is used to calculate local for mitigating increases in surface air temperatures associated with the urban heat island (UHI). A key step

  17. Metropolitan-scale Transport and Dispersion from the New York World Trade Center Following September 11, 2001. Part I

    E-Print Network [OSTI]

    Raman, Sethu

    System (ARPS) and 5th Generation Mesoscale Model (MM5) in the complex marine-influenced urban setting of NYC. Results indicate wind speed, in most cases, is greater in CALMET than the two mesoscale models resolved by the mesoscale models, were not well simulated by CALMET. Independent wind observations in Lower

  18. Connecting Land Use and Transportation Toward Sustainable Development: A Case Study of Houston-Galveston Metropolitan Area 

    E-Print Network [OSTI]

    Lee, Jae Su

    2011-02-22

    How do land use characteristics affect individual and household travel behavior in a regional context? Can the investigation justify the land use policies to reduce automobile dependence and achieve the goals of sustainable ...

  19. Acknowledgements. This work was partially supported by NSF CAREER IIS-0845282, ARO YIP W911NF-11-1-0090 and DARPA Mind's Eye W911NF-10-2-0062.

    E-Print Network [OSTI]

    Krovi, Venkat

    in the final segmentation based on various post hoc feature criteria, such as motion, object-ness or human-ness: - Unsupervised: Motion. - Supervised, Category-Independent: Object-ness. - Supervised: Human-ness, Car-ness, etc and Flattening) UES on Human-ness (Selection and Flattening) UES on Car-ness (Selection a

  20. DETEW!INATION OF THE NEUTRON MAGNETIC FlONENT G.L. Greene and N.F. Ramsey

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would like submit theCovalent Bonding Low-Cost Ground8 Gas

  1. XIAP and cIAP1 amplifications induce Beclin 1-dependent autophagy through NF?B activation

    E-Print Network [OSTI]

    Lin, Fang; Ghislat, Ghita; Luo, Shouqing; Renna, Maurizio; Siddiqi, Farah; Rubinsztein, David C.

    2015-02-10

    and on the cell or tissue context. Furthermore, it is possible that the expression of certain proteins associated with cancer riskmayaffect both autophagy and apoptosis and the pro- ducts of this interplay may be relevant to the disease. Inhibitors of apoptosis...

  2. JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation

    E-Print Network [OSTI]

    Tsai, Ming-Daw

    of transcription factors is essential for correct programming of cell proliferation and differentiation. We have and nuclear hormones all play important roles in the maturation of erythroid cells. For exam- ple, it is known that signaling from the erythropoietin (Epo) receptor activates several pathways to promote cell proliferation

  3. Functions of receptor activator of NF-?B ligand (RANKL) and its receptors, RANK and OPG, are evolutionarily conserved 

    E-Print Network [OSTI]

    Sutton, Kate Maurice

    2014-11-28

    The tumour necrosis factor (TNF) superfamily is a group of cytokines that orchestrate a variety of functions, both in the development of the architecture of immune organs and of the immune response. The mammalian TNF ...

  4. Stepwise contraction of the nf Rydberg shells in the 3d photoionization of multiply-charged xenon ions

    E-Print Network [OSTI]

    Schippers, S; Buhr, T; Hellhund, J; Holste, K; Kilcoyne, A L D; Klumpp, S; Martins, M; Müller, A; Ricz, S; Fritzsche, S

    2014-01-01

    Triple photoionization of Xe3+, Xe4+ and Xe5+ ions has been studied in the energy range 670-750 eV, including the 3d ionization threshold. The photon-ion merged-beam technique was used at a synchrotron light source to measure the absolute photoionization cross sections. These cross sections exhibit a progressively larger number of sharp resonances as the ion charge state is increased. This clearly visualizes the re-ordering of the $\\epsilon$f continuum into a regular series of (bound) Rydberg orbitals as the ionic core becomes more attractive. The energies and strengths of the resonances are extracted from the experimental data and are further analyzed by relativistic atomic-structure calculations.

  5. QCD thermodynamics with $N_f=2+1$ near the continuum limit at realistic quark masses

    E-Print Network [OSTI]

    Takashi Umeda

    2006-10-03

    We report on our study of QCD thermodynamics with 2+1 flavors of dynamical quarks. In this proceeding we present several thermodynamic quantities and our recent calculation of the critical temperature. In order to investigate the thermodynamic properties of QCD near the continuum limit we adopt improved staggered (p4) quarks coupled with tree-level Symanzik improved glue on $N_t=4$ and 6 lattices. The simulations are performed with a physical value of the strange quark mass and light quark masses which are in the range of $m_q/m_s=0.05-0.4$. The lightest quark mass corresponds to a pion mass of about 150 MeV.

  6. An Epigenetic Switch Involving NF-kB, Lin28, Let-7 MicroRNA, and IL6 Links

    E-Print Network [OSTI]

    proinflammatory cytokines and chemokines, seems to be a key molecular link between inflammation and oncogenesis

  7. Modulation of host NF-[k??a?p?p?a?]B pathway by the Toxoplasma gondii secreted factor, GRA15

    E-Print Network [OSTI]

    Lu, Diana, Ph. D. Massachusetts Institute of Technology

    2013-01-01

    The apicomplexan protozoan Toxoplasma gondii is an obligate intracellular pathogen that infects all warm blooded animals, including nearly thirty percent of the human population worldwide. Toxoplasma's success as a parasite ...

  8. ineralization of acid and sweet whey. There would be about 150 000200 000 m2 of NF

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    properties [13]. In crossflow filtration of whey using organic membranes, the most important fouling to fouling. Some studies have demonstrated that the hydrodynamic operating conditions of mem- brane crossflow

  9. Enhancement of CD8+ T-cell memory by removal of a vaccinia virus NF-?B inhibitor

    E-Print Network [OSTI]

    Ren, Hongwei; Ferguson, Brian J.; de Motes, Carlos Maluquer; Sumner, Rebecca P.; Harman, Laura; Smith, Geoffrey L.

    2014-11-07

    % paraformaldehyde (Sigma-Aldrich, St Louis, MO). Flow cytometry was performed with a BD LSR Fortessa (BD Biosciences), and data were analysed with FLOWJO software (Tree Star Inc., Ashland, OR). LIVE/DEAD? Fixable Aqua Dead Cell Stain Kit (Life Technologies, Paisley... , UK) was used to exclude non-via- ble cells from analysis. Flow cytometric gating strategies are shown in Supplementary Figure S3. DimerX assay to detect VACV specific CD8+ T cells Recombinant soluble dimeric mouse H-2Kb:Ig fusion pro- teins were...

  10. MODULATION OF THE NF-KAPPA B SIGNALING PATHWAY BY THE BACTERIAL TYPE III SECRETION SYSTEM EFFECTORS

    E-Print Network [OSTI]

    Gao, Xiaofei

    2012-08-31

    G PAMPs: Pathogen associated molecular patterns PRRs: Pattern recognition receptors PI: Phosphoinositide RING: Really Interesting New Gene RPS3: Ribosomal protein subunit 3 Stx: Shiga toxins TAK1: Transforming growth factor-activated protein....coli) is one of the most studied microorganism. It has been used as a model organism for a variety of biological purposes. Recent studies showed that E. coli is an extremely versatile organism with high genome plasticity (Hacker et al., 1997). Studies in E...

  11. Iowa Water and Wastewater Operators Seek SEP Certification in...

    Broader source: Energy.gov (indexed) [DOE]

    Representatives from the Des Moines Metropolitan WRA and Des Moines Water Works sign the SEP agreement. The Des Moines Metropolitan Wastewater Reclamation Authority (WRA) and Des...

  12. Philadelphia’s Space In Between: Inner-Ring Suburb Evolution

    E-Print Network [OSTI]

    Green Leigh, Nancey; Lee, Sugie

    2005-01-01

    Institution. Metropolitan Philadelphia Policy Center. 2001.Or Fight! Metropolitan Philadelphia and Its Future. RegionalAll Rights Reserved. Philadelphia’s Space In Between: Inner-

  13. Metropolitan High-Technology Industry Growth in the Mid 1970s: Can Everyone Have a Slice of the High-Tech Pie

    E-Print Network [OSTI]

    Glasmeier, Amy; Hall, Peter; Markusen, Ann R.

    1984-01-01

    surroundi ng high-technology (high-tech) i ndus­ tries is incommunities compete for high - tech employment with only agoverning the diffusion of high-tech development. All too

  14. Metropolitan High-Technology Industry Growth in the Mid 1970s: Can Everyone Have a Slice of the High-Tech Pie

    E-Print Network [OSTI]

    Glasmeier, Amy; Hall, Peter; Markusen, Ann R.

    1984-01-01

    tion and Gro wth in High Technology Industries: A R egionalC . Burke , Thomas. 1 97 9 . High Technology En terprise in1 9 83c. De fining High Technology Industries. I nstitute of

  15. Metropolitan High-Technology Industry Growth in the Mid 1970s: Can Everyone Have a Slice of the High-Tech Pie

    E-Print Network [OSTI]

    Glasmeier, Amy; Hall, Peter; Markusen, Ann R.

    1984-01-01

    such as crystal-growth technology. The second measure ,sustained economic growth (Office of Technology Assessmen t,TABLE 1 High Technology Industries Growth Performance, 1972-

  16. The correlational and causal investigation into the land use-transportation relationships: evidence from the Dallas-Fort Worth metropolitan area 

    E-Print Network [OSTI]

    Lee, Sangkug

    2006-10-30

    The role of land-use and related policies in reducing automobile dependence has been the subject of heated policy debate for over two decades. Previous research has shed light on the correlations between land-use and travel. ...

  17. Using a Regional Chemical Transport Model for the Analysis of Gaseous and Particulate Air Pollutants in the Mexico City Metropolitan Area 

    E-Print Network [OSTI]

    Ali, Sajjad Ghulam

    2012-02-14

    -Chem). The simulation period was March 2-7, 2006. Hourly species concentrations of O3, NOx, CO, SO2, PM10, and PM2.5 for the period were provided by the Automatic Air Quality Monitoring Network (labeled as RAMA). Preliminary evaluation showed GEOS-Chem and CMAQ being...

  18. Investigations of Atmospheric and Plant Physiological Effects along an Urban-To-Rural Gradient in the Houston Metropolitan Area Comparing 2011 to 2012 

    E-Print Network [OSTI]

    Gramann, Jonathan

    2014-09-02

    to rural trees. To study this, an urban0to-rural gradient was set up starting near downtown Houston, TX, and extending north approximately 90 km. Three weather stations were erected along this gradient to continually monitor weather. Photosynthesis rates...

  19. A COMPARISON OF OBJECT-BASED WITH PIXEL-BASED LAND COVER CHANGE DETECTION IN THE BALTIMORE METROPOLITAN AREA USING MULTITEMPORAL

    E-Print Network [OSTI]

    Vermont, University of

    A COMPARISON OF OBJECT-BASED WITH PIXEL-BASED LAND COVER CHANGE DETECTION IN THE BALTIMORE portions of Baltimore City and Baltimore County, Maryland, USA. The results indicated that the object- classification change detection, high-spatial resolution image, urban area, Baltimore, LTER. 1. INTRODUCTION

  20. Investigation of surface inhomogeneity and estimation of the GOES skin temperature assimilation errors of the MM5 implied by the inhomogeneity over Houston metropolitan area 

    E-Print Network [OSTI]

    Han, Sang-Ok

    2005-11-01

    by about 25 %, thereby inducing the warmer (0.7 %) and drier (-1.0 %) PBL and the colder and moister PBL top induced by greater turbulent diffusivities. The 3-d application of the inhomogeneity parameterization indicated consistent results with the 1-d...

  1. Implementing the Americans with Disabilities Act of 1990: an evaluation of the Metropolitan Transit Authority of Harris County's Freedom Passport Program 

    E-Print Network [OSTI]

    Ricci, Janet

    1993-01-01

    for use by disabled individuals, including hydraulic wheelchair lifts. In addition, paratransit service of comparable quality, must be provided for those individuals who are unable to use accessible fixed-route service. Many U.S. transit agencies...

  2. The Residential Segregation of Same-Sex Partnered Households from Heterosexual Partnered Households: Metropolitan Statistical Areas in the U.S., 2010 

    E-Print Network [OSTI]

    Deng, Xiaodan

    2015-05-12

    to date. Figure 1, reproduced from Duncan and Duncan (1955), shows a geometrical def- inition of D as the maximum vertical dis- tance between the "segregation curve" and the curve Y = X. The segregation curve is the plot of the cumulative proportion... of whites versus the cumulative proportion of nonwhites, where the respective cumula- tions are obtained by taking the census tracts in order of increasing nonwhite per- centages. The Duncans provided a set of inade- quacies and precautionary comments...

  3. DATE COURT GROUP G.NO. TIME TEAM A VS TEAM B ST MARY'S A 1 08H00 NELSON MANDELA METROPOLITAN UNIVERSITY VS UNIVERSITY OF JOHANNESBURG

    E-Print Network [OSTI]

    Wagner, Stephan

    CENTRAL UNIVERSITY OF TECHNOLOGY COURT STATUS G.NO. TIME TEAM A VS TEAM B TUKS B 43 14H00 POS B7 WOMEN VS POS A7 WOMEN ST MARY'S 43 14H00 POS B7 VS POS A7 PRETORIA CLUB 11 & 12 44 14H00 POS A6 VS POS B6 TUKS A 1/2 FINAL 44 15H30 POS B1 WOMEN VS POS A2 WOMEN ST MARY'S 11 & 12 45 15H30 POS A6 WOMEN VS POS B6

  4. Evaluation of the volatility basis-set approach for the simulation of organic aerosol formation in the Mexico City metropolitan area

    E-Print Network [OSTI]

    Tsimpidi, A. P.

    New primary and secondary organic aerosol modules have been added to PMCAMx, a three dimensional chemical transport model (CTM), for use with the SAPRC99 chemistry mechanism based on recent smog chamber studies. The new ...

  5. The value trees contribute to residential property in the Austin metropolitan area: a factor in assessing the impact of oak wilt 

    E-Print Network [OSTI]

    Martin, Clay Whitney

    1986-01-01

    rt 0 nl 0 Ql 8 4 CQ 't5 8 8 Ql ) tt 8 A 'CI nl tn A 8 8 8 rt 0l kr IQ 0 0 Ql 0 8 In 8 ) '0 nl 0 Ql IQ M 8 8 K ) QQ D Ot I0 A Ot nQ 0 M Cl a ot QO OQ Ul P4 g R 0 0 0 IX 0 x IO M 4V QQ M r tel M rV 0 0 nt 0 Ifl rn to d... 0 IO 0 'IO IO m OI Ifl CO 'IO m r Ifl r nt tlt m ft tfr 0 0 0 0 Pl Pl fr PI tn 0' 8 0 tt 8 0 0 0 0 8 0 0 nl nl M tt Cl 0 IQ 0 OQ nn 0 34 Predictive Modeling Method A regression model was developed in order to predict tree value...

  6. Kentucky Water Resources Research Institute Annual Technical Report

    E-Print Network [OSTI]

    , and the Metropolitan Sewer District funded activities addressing Beargrass Creek Combined Sewer Overflows in Louisville

  7. Summary of Activities at the ST. LOUIS DOWNTOWN SITE

    E-Print Network [OSTI]

    US Army Corps of Engineers

    Salt South PSC Metals Inc. St. Louis Metropolitan Sewer District Lift Station Midtown Garage Hjersted

  8. Inductive machine learning for improved estimation of catchment-scale snow water equivalent

    E-Print Network [OSTI]

    Bongard, Josh

    agricultural planning, metropolitan use, flood risk evaluation, planning of hydropower production potential

  9. Atmos. Chem. Phys., 10, 53715389, 2010 www.atmos-chem-phys.net/10/5371/2010/

    E-Print Network [OSTI]

    Meskhidze, Nicholas

    % prompt and 30% slow evapora- tion) at a site northwest from the metropolitan area (PEMEX Correspondence

  10. CILAS Newslettter Summer 2004

    E-Print Network [OSTI]

    Center for Iberian and Latin American Studies

    2004-01-01

    Autonomous University of Xochimilco, Mexico, his specialtyMetropolitan University, Xochimilco (Mexico City); Lia

  11. 1992 CBECS C & E

    U.S. Energy Information Administration (EIA) Indexed Site

    of District Heat by End Use, 1989 District Heat Consumption (trillion Btu) Space Water a Total Heating Heating Other RSE Building Row Characteristics Factor 1.0 NF NF NF RSE...

  12. 1992 CBECS C & E

    U.S. Energy Information Administration (EIA) Indexed Site

    0. Consumption of Fuel Oil by End Use, 1989 Fuel Oil Consumption (trillion Btu) Space Water a Total Heating Heating Other RSE Building Row Characteristics Factor 1.0 NF NF NF RSE...

  13. Microstructural evolution in NF616 (P92) and Fee9Cre0.1C-model alloy under heavy ion irradiation

    E-Print Network [OSTI]

    Motta, Arthur T.

    .V. All rights reserved. 1. Introduction High chromium (9e12 wt.%) ferritic-martensitic (FeM) steels]. Normalized and tempered 9e12 wt.% FeM steels typically exhibit the tempered martensite structure reactor Heavy ion irradiation In situ technique Transmission electron microscopy Ferritic-martensitic

  14. TWIST1 associates with NF-kappaB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 production

    E-Print Network [OSTI]

    2012-01-01

    in (A). Scale bar, 160 ?m. (D) Gelatin zymography assays ofin ECM degradation. Using gelatin zymography, we found thatmanufac- turer’s guidelines. Gelatin zymography Conditioned

  15. TNF{alpha} induced FOXP3-NF{kappa}B interaction dampens the tumor suppressor role of FOXP3 in gastric cancer cells

    SciTech Connect (OSTI)

    Hao, Qiang; Li, Weina; Zhang, Cun; Qin, Xin; Xue, Xiaochang; Li, Meng; Shu, Zhen; Xu, Tianjiao; Xu, Yujin; Wang, Weihua [The State Key Laboratory of Cancer Biology, School of Pharmacy, Department of Biopharmaceutics, Fourth Military Medical University, Xi'an 710032 (China)] [The State Key Laboratory of Cancer Biology, School of Pharmacy, Department of Biopharmaceutics, Fourth Military Medical University, Xi'an 710032 (China); Zhang, Wei, E-mail: Zhangw90@fmmu.edu.cn [The State Key Laboratory of Cancer Biology, School of Pharmacy, Department of Biopharmaceutics, Fourth Military Medical University, Xi'an 710032 (China)] [The State Key Laboratory of Cancer Biology, School of Pharmacy, Department of Biopharmaceutics, Fourth Military Medical University, Xi'an 710032 (China); Zhang, Yingqi, E-mail: Zhangyqh@fmmu.edu.cn [The State Key Laboratory of Cancer Biology, School of Pharmacy, Department of Biopharmaceutics, Fourth Military Medical University, Xi'an 710032 (China)] [The State Key Laboratory of Cancer Biology, School of Pharmacy, Department of Biopharmaceutics, Fourth Military Medical University, Xi'an 710032 (China)

    2013-01-04

    Highlights: Black-Right-Pointing-Pointer FOXP3 inhibition of cell proliferation is p21-dependent under basal conditions. Black-Right-Pointing-Pointer Inflammation induced by TNF{alpha} inhibits the tumor suppressor role of FOXP3. Black-Right-Pointing-Pointer Interaction between p65 and FOXP3 inhibits p21 transcription activation. -- Abstract: Controversial roles of FOXP3 in different cancers have been reported previously, while its role in gastric cancer is largely unknown. Here we found that FOXP3 is unexpectedly upregulated in some gastric cancer cells. To test whether increased FOXP3 remains the tumor suppressor role in gastric cancer as seen in other cancers, we test its function in cell proliferation both at basal and TNF{alpha} mimicked inflammatory condition. Compared with the proliferation inhibitory role observed in basal condition, FOXP3 is insufficient to inhibit the cell proliferation under TNF{alpha} treatment. Molecularly, we found that TNF{alpha} induced an interaction between FOXP3 and p65, which in turn drive the FOXP3 away from the promoter of the well known target p21. Our data here suggest that although FOXP3 is upregulated in gastric cancer, its tumor suppressor role has been dampened due to the inflammation environment.

  16. GaAs 0.5 dB NF dual-loop negative-feedback broadband low-noise amplifier IC

    E-Print Network [OSTI]

    Serdijn, Wouter A.

    ) designed for the square kilometre array is presented. Effects of transformer non-idealities on LNA is obtained by increasing the collecting area to approxi- mately one square kilometre. This square kilometre array (SKA) [1] employs approximately 100 million antennas that are connected in a phased array, forming

  17. Leading-order hadronic contribution to the anomalous magnetic moment of the muon from N_f=2+1+1 twisted mass fermions

    SciTech Connect (OSTI)

    Burger, Florian [Humboldt U. Berlin; Feng, Xu [KEK; Hotzel, Grit [Humboldt U. Berlin; Jansen, Karl [DESY; Petschlies, Marcus [The Cyprus Institute; Renner, Dru B. [JLAB

    2013-11-01

    We present results for the leading order QCD correction to the anomalous magnetic moment of the muon including the first two generations of quarks as dynamical degrees of freedom. Several light quark masses are examined in order to yield a controlled extrapolation to the physical pion mass. We analyse ensembles for three different lattice spacings and several volumes in order to investigate lattice artefacts and finite-size effects, respectively. We also provide preliminary results for this quantity for two flavours of mass-degenerate quarks at the physical value of the pion mass.

  18. Distinct NF-kB activation pathways engaged by T-cell receptor and co-receptor CD28 on T-cells

    E-Print Network [OSTI]

    Thaker, Youg Raj; Rudd, Christopher E

    2015-03-02

    at the pro-T3 stage [16]. In addition to this, Jurkat T-cell mutant lines lacking either SLP-76 or LAT expression showed a vital requirement of both molecules in mediating TCR-induced PLC?1 phosphorylation, extracellular signal-regulated kinase (ERK...

  19. Stimulation of Fas (CD95) induces production of pro-inflammatory mediators through ERK/JNK-dependent activation of NF-jB in THP-1 cells

    E-Print Network [OSTI]

    Lee, Won-Ha

    Stimulation of Fas (CD95) induces production of pro-inflammatory mediators through ERK is mediated by mitogen activated protein kinases (MAPKs) including extracellular-signal-regulated kinase (ERK inducing molecule through interaction with its counterpart and Fas-mediate events are mediated by ERK

  20. Regulation of cytochrome P450 3A4 gene expression through modulating pregnane X receptor transcriptional activity by NF-? aryl hydrocarbon receptor and xenobiotics 

    E-Print Network [OSTI]

    Gu, Xinsheng

    2009-05-15

    Cytochrome P450 3A4 (CYP3A4) is a key enzyme responsible for the metabolism of drugs and endogenous compounds in human liver and intestine. CYP3A4 gene expression is mainly regulated by Pregnane X receptor (PXR) which is ...

  1. The Low Energy Constants of $SU(2)$ Partially Quenched Chiral Perturbation Theory from $N_{f}=2+1$ Domain Wall QCD

    E-Print Network [OSTI]

    Boyle, P A; Garron, N; Jung, C; Jüttner, A; Kelly, C; Mawhinney, R D; McGlynn, G; Murphy, D J; Ohta, S; Portelli, A; Sachrajda, C T

    2015-01-01

    We have performed fits of the pseudoscalar masses and decay constants, from a variety of RBC-UKQCD domain wall fermion ensembles, to $SU(2)$ partially quenched chiral perturbation theory at next-to leading order (NLO) and next-to-next-to leading order (NNLO). We report values for 9 NLO and 8 linearly independent combinations of NNLO partially quenched low energy constants, which we compare to other lattice and phenomenological determinations. We discuss the size of successive terms in the chiral expansion and use our large set of low energy constants to make predictions for mass splittings due to QCD isospin breaking effects and the S-wave $\\pi \\pi$ scattering lengths. We conclude that, for the range of pseudoscalar masses explored in this work, $115~\\mathrm{MeV} \\lesssim m_{\\rm PS} \\lesssim 430~\\mathrm{MeV}$, the NNLO $SU(2)$ expansion is quite robust and can fit lattice data with percent-scale accuracy.

  2. A Smac-mimetic sensitizes prostrate cancer cells to TRAIL-induced apoptosis via modulating IAPs and NF-kappaB

    E-Print Network [OSTI]

    Dai, Yao; Liu, Meilan; Tang, Wenhua; Li, Yongming; Lian, Jiqin; Lawrence, Theodore S.; Xu, Liang

    2009-11-06

    Background: Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising agent for human cancer therapy, prostate cancer still remains resistant to TRAIL. Both X-linked inhibitor of apoptosis (XIAP) and nuclear factor...

  3. Structure and Biochemistry of IKappaB Zeta : : A Nuclear IKappaB Protein

    E-Print Network [OSTI]

    Zhu, Norman L.

    Bcl-3 is an antagonist of pSO/NF-?B-mediated inhibition. ,Bcl-3 is an antagonist of pSO/NF-?B-mediated inhibition. ,

  4. Helper's Network Gazette October 1995 

    E-Print Network [OSTI]

    1995-01-01

    This study examines the residential outcomes of Latinos in major metropolitan areas using new methods to connect micro-level analyses of residential attainments to overall patterns of segregation in the metropolitan area. ...

  5. Latino Residential Segregation in the United States: Applying New Methods to Gain New Understandings 

    E-Print Network [OSTI]

    Fox, Amber Raquel

    2014-12-04

    This study examines the residential outcomes of Latinos in major metropolitan areas using new methods to connect micro-level analyses of residential attainments to overall patterns of segregation in the metropolitan area. ...

  6. Introduction: Transportation Planning as an Integral Part of Urban Development: The Emerging Paradigm

    E-Print Network [OSTI]

    Deakin, Elizabeth A.

    2008-01-01

    effectively with metropolitan flood risk could increase asare already located on high-risk flood- transport modes are

  7. Vertical Relationships and Competition in Retail Gasoline Markets: An Empirical Evidence from Contract Changes in Southern California

    E-Print Network [OSTI]

    Hastings, Justine

    2000-01-01

    that, within each metropolitan area, the pre-buyout andpost-buyout levels and trends are very similar between the

  8. Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NF{kappa}B and AhR and EGFR-ERK pathway

    SciTech Connect (OSTI)

    Potapovich, Alla I. [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy); Biology Department, Belarus State University, Skorina Prosp. 10, Minsk 220050 (Belarus); Lulli, Daniela; Fidanza, Paolo [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy); Kostyuk, Vladimir A. [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy); Biology Department, Belarus State University, Skorina Prosp. 10, Minsk 220050 (Belarus); De Luca, Chiara; Pastore, Saveria [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy); Korkina, Liudmila G., E-mail: l.korkina@idi.it [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy)

    2011-09-01

    Molecular mechanisms underlying modulation of inflammatory responses in primary human keratinocytes by plant polyphenols (PPs), namely the glycosylated phenylpropanoid verbascoside, the stilbenoid resveratrol and its glycoside polydatin, and the flavonoid quercetin and its glycoside rutin were evaluated. As non-lethal stimuli, the prototypic ligand for epidermal growth factor receptor (EGFR) transforming growth factor alpha (TGFalpha), the combination of tumor necrosis factor (TNFalpha) and interferon (IFNgamma) (T/I), UVA + UVB irradiation, and bacterial lipopolysaccharide (LPS) were used. We demonstrated differential modulation of inflammatory responses in keratinocytes at signal transduction, gene transcription, and protein synthesis levels as a function of PP chemical structure, the pro-inflammatory trigger used, and PP interaction with intracellular detoxifying systems. The PPs remarkably inhibited constitutive, LPS- and T/I-induced but not TGFalpha-induced ERK phosphorylation. They also suppressed NFkappaB activation by LPS and T/I. Verbascoside and quercetin invariably impaired EGFR phosphorylation and UV-associated aryl hydrocarbon receptor (AhR)-mediated signaling, while rutin, polydatin and resveratrol did not affect EGFR phosphorylation and further activated AhR machinery in UV-exposed keratinocytes. In general, PPs down-regulated gene expression of pro-inflammatory cytokines/enzymes, except significant up-regulation of IL-8 observed under stimulation with TGFalpha. Both spontaneous and T/I-induced release of IL-8 and IP-10 was suppressed, although 50 {mu}M resveratrol and polydatin up-regulated IL-8. At this concentration, resveratrol activated both gene expression and de novo synthesis of IL-8 and AhR-mediated mechanisms were involved. We conclude that PPs differentially modulate the inflammatory response of human keratinocytes through distinct signal transduction pathways, including AhR and EGFR. - Graphical abstract: Display Omitted Highlights: > Effects of plant polyphenols on inflammatory responses in human keratinocytes. > Inflammatory stimuli used: TGFalpha, TNFalpha+IFNgamma, UVA+UVB, and LPS. > Inflammatory pathways connected with NFB, ERK1/2, EGFR, and AhR were investigated. > Plant polyphenols, flavonoids, stilbenoids, and phenylpropanoids, were studied. > Modulation of inflammation depends on phenolic core structure and glycosylation.

  9. NF-kappa B- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: A novel effect of a probiotic bacterium

    E-Print Network [OSTI]

    2004-01-01

    and E. Isolauri. 2002. Probiotics: an overview of bene?cial17. Isolauri, E. 2001. Probiotics in human disease. Am. J.and S. Salminen. 2002. Probiotics: a role in the treatment

  10. Bestelmeyer, BT, GS Okin, MC Duniway, SR Archer, NF Sayre, JC Williamson, JE Herrick. 2014. Desertification, land use and the transformation of global drylands. Frontiers in Ecology and the

    E-Print Network [OSTI]

    Archer, Steven R.

    . Desertification, land use and the transformation of global drylands. Frontiers in Ecology and the Environment : In Press Desertification is an escalating concern in global drylands, yet assessments to guide are involved. In order to provide greater clarity, we propose that assessments of desertification and land

  11. High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53 - NF-kappaB - complex-dependent gene expression in human heart failure

    E-Print Network [OSTI]

    Choy, Mun-Kit; Movassagh, Mehregan; Siggens, Lee; Vujic, Ana; Goddard, Martin; Sanchez, Ana; Perkins, Neil; Figg, Nichola; Bennett, Martin; Carroll, Jason; Foo, Roger S.-Y.

    2010-06-14

    with this cis-element. Using high-throughput sequencing, we analyzed genome-wide binding sites for the p53-RELA complex in diseased and control human hearts and found a significant overrepresentation of the STAT3 motif. We further determined that STAT3...

  12. Quality and Membrane Treatability of the Lake Houston Water Supply 

    E-Print Network [OSTI]

    Chellam, Shankar; Sharma, Ramesh; Shetty, Grishma; Wei, Ying

    2001-10-01

    fouling rates and increase chemical cleaning intervals during surface water nanofiltration (NF) (4). Therefore, an integrated membrane system employing MF or UF pretreatment to NF is expected to be an important treatment candidate for Lake Houston water...

  13. Dysregulation of nuclear factor kappa B activity and osteopontin expression in oxidant-induced atherogenesis 

    E-Print Network [OSTI]

    Williams, Edward Spencer

    2004-09-30

    NF-?B activity is critical in the regulation of atherosclerotic vascular smooth muscle cell (vSMC) phenotypes induced following oxidative injury by allylamine. The present studies were designed to detail dysregulation of NF-?B activity...

  14. ORIGINAL PAPER P. R. Territo J. Altimiras

    E-Print Network [OSTI]

    Altimiras, Jordi

    - metamorphic climax). Surface area [8.5 mm2 at stages Nieuwkoop-Faber (NF) 33±34 to 70.2 mm2 at stages NF 50±51 (hemoglobin poisoning with carbon monoxide), whole animal surface area and volume were measured and bulk] and volume (1.8 mm3 at stages NF 33±34 to 35.7 mm3 at stages NF 50±51) measured from volu- metric analysis

  15. Publication Date 4/1/2015 FEDERAL RECREATION AREA/SITE PHONE CITY STATE WEBSITE ANNUAL SENIOR ACCESS

    E-Print Network [OSTI]

    /coconino/contact/index.shtml YES YES YES Coconino NF - Peaks & Mormon Lake District 928-526-0866 Flagstaff

  16. {ksj, ms9405, ms9504}@cis.scu.edu.tw {churen, isu}@gate.sinica.edu.tw

    E-Print Network [OSTI]

    81 976 Nf, Nf, Nf 47 4,574 T, T, I 1567 35,645 XML word, pos="100863"> pos> pos>Nh> id=1 sent id=18 sent id=21 w id=1 w id=10 w id=11 w id=15 word D pos 0200 tag1 word D pos 0200

  17. EnergyWorks KC's Training Programs Provide Job Opportunities...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Kansas City area. Successes include the Metropolitan Energy Center's training for professions such as commercial energy auditors, weatherization installation contractors, and...

  18. Kentucky Water Resources Research Institute Annual Technical Report

    E-Print Network [OSTI]

    Public Outreach Program. The Metropolitan Sewer District funded activities addressing Beargrass Creek combined sewer overflows in the Louisville area. The Kentucky Department for Environmental Protection also

  19. Kentucky Water Resources Research Institute Annual Technical Report

    E-Print Network [OSTI]

    Public Outreach Program. The Metropolitan Sewer District funded activities addressing Beargrass Creek combined sewer overflows in Louisville. The Kentucky Department for Environmental Protection also supported

  20. Multi-Channel and Multi-Rate Adaptation for High-Throughput Wireless Networks

    E-Print Network [OSTI]

    Nguyen, Duy Duc

    2012-01-01

    layer. Unlike wired networks, wireless networks have to deal2 Background Wireless Networks Wireless technology is allWLAN), wireless mesh networks, wireless metropolitan area

  1. Department of Electrical and Electronic Engineering updated on July 25, 2011 MSc Courses for Undergraduate Students as Depth Courses (2011-2012)

    E-Print Network [OSTI]

    Leung, Ka-Cheong

    for metropolitan cities 2 6 ELEC6095 Smart Grid 2 6 ELEC6602 Business Venture in China 2 6 X X X X ELEC7144

  2. Does a High Tech Boom Worsen Housing Problems for Working Families?

    E-Print Network [OSTI]

    Querica, Roberto G.; Stegman, Michael A.; Davis, Walter R.

    2001-01-01

    Dynamics and Outcomes in High- Tech Economies. Presented atthis is the case in areas experiencing high tech growth.Metropolitan areas promoting high tech growth would do well

  3. A Blueprint for Urban Sustainability: Integrating Sustainable...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    A Blueprint for Urban Sustainability: Integrating Sustainable Energy Practices into Metropolitan Planning, May 2004 A Blueprint for Urban Sustainability: Integrating Sustainable...

  4. Green Buildings in Green Cities: Integrating Energy Efficiency into the Real Estate Industry

    E-Print Network [OSTI]

    Bardhan, Ashok; Kroll, Cynthia A.

    2011-01-01

    2008. Shrinking the Carbon Footprint of Metropolitan US. TheUnited States. Their carbon footprint is significant. Thecompanywide (worldwide) carbon footprint, at the other end

  5. Handling Globalization: Labor, Capital, and Class in the Globalized Warehouse and Distribution Center

    E-Print Network [OSTI]

    Struna, Jason Young

    2015-01-01

    Francois Nielsen. 1999. "Income Inequality, Development, andand the Great U-Turn: Income Inequality Trends in 16 OECDMovement and Metropolitan Inequality: Global Restructuring,

  6. Green Buildings in Green Cities: Integrating Energy Efficiency into the Real Estate Industry

    E-Print Network [OSTI]

    Bardhan, Ashok; Kroll, Cynthia A.

    2011-01-01

    of green and energy efficient buildings throughout the urbancosts of green and energy efficient buildings, barriers toof green or energy-efficient buildings across a metropolitan

  7. Massachusetts Clean Air Act (Massachusetts)

    Broader source: Energy.gov [DOE]

    The Act contains regulations to prevent the pollution and contamination of the atmosphere. The Act establishes a contiguous metropolitan pollution control district, comprised of towns in the...

  8. Main Panel I Professor David Otley Lancaster University

    E-Print Network [OSTI]

    Abrahams, I. David

    and Political Science Mr Jonathan Portes Department for Work and Pensions Professor Jonathan Thomas University of Scotland Professor Alistair Black Leeds Metropolitan University Professor Elisabeth Davenport Napier

  9. Land use regulation and intraregional population-employment interaction

    E-Print Network [OSTI]

    Kim, JH; Hewings, GJD

    2013-01-01

    Levine J (2006) Zoned out: Regulation, markets, and choicesprices, externalities, and regulation in U.S. metropolitanCT (2000) Land use regulation and new construction. Regional

  10. Disastrous Response to Natural and Man-Made Disasters: An Environmental Justice Analysis Twenty-Five Years after Warren County

    E-Print Network [OSTI]

    Bullard, Robert D.; Wright, Beverly

    2008-01-01

    of 149) metropolitan areas with hazardous waste sites (70%)concentrated in areas with com- mercial hazardous sites thanhazardous waste facilities, nearly doubling the percentage in areas

  11. ACCESS Magazine Fall 2008

    E-Print Network [OSTI]

    2008-01-01

    effectively with metropolitan flood risk could increase asspecies, residual flood risk continued land subsidence, andthe source of serious flood risks that, as we witnessed in

  12. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Combined Heat & Power Tax Credits, Rebates & Savings Tax Credits, Rebates & Savings Metropolitan Edison Company SEF Loans (FirstEnergy Territory) The fund is designed to...

  13. Microsoft Word - Test4.doc

    U.S. Energy Information Administration (EIA) Indexed Site

    prevailed in the four metropolitan areas monitored by this report (Chicago, Kansas City, New York, and Pittsburgh) and throughout most of the country. Temperatures in the Rocky...

  14. Visualizing Energy Infrastructure Exposure to Storm Surge and...

    Energy Savers [EERE]

    energy infrastructure, focused on four major metropolitan statistical areas (MSAs): New York City, Houston, Miami, and Los Angeles. Since then, Boston, Philadelphia, and Norfolk...

  15. Microsoft Word - ngw0217.doc

    U.S. Energy Information Administration (EIA) Indexed Site

    price. Average temperatures in the four metropolitan areas (Chicago, Kansas City, New York, and Pittsburgh) monitored for this report were 10 to 14 degrees warmer than...

  16. weekly

    U.S. Energy Information Administration (EIA) Indexed Site

    week in the four metropolitan areas monitored by this report (Chicago, Kansas City, New York City, and Pittsburgh). Friday, the first full day of spring, saw daytime temperatures...

  17. AVTA: Chargepoint America | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Chargepoint America AVTA: Chargepoint America ChargePoint America deployed 4,600 public and private charging stations in 9 metropolitan areas. ChargePoint America Recovery Act...

  18. Penelec SEF of the Community Foundation for the Alleghenies Loan...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Program Summary FirstEnergy (formerly GPU) established the Metropolitan Edison Company Sustainable Energy Fund and the Penelec Sustainable Energy Fund in 2000. The Community...

  19. Energize New York Data Dashboard | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    New York Data Dashboard More Documents & Publications Lowell, Massachusetts Data Dashboard Chicago Metropolitan Agency for Planning Data Dashboard Austin Energy Data Dashboard...

  20. Energy Savings Calculations for Heat Island Reduction Strategies in Baton Rouge, Sacramento and Salt Lake City

    E-Print Network [OSTI]

    Konopacki, S.; Akbari, H.

    2000-01-01

    Commission Report P300-94-007. Sacramento, CA. Commercialthe (New Orleans, Sacramento & Salt Lake City) MetropolitanStrategies in Baton Rouge, Sacramento and Salt Lake City S.

  1. Collaboration Is Not Enough: Virtuous Cycles of Reform in Transportation Policy

    E-Print Network [OSTI]

    Weir, Margaret; Rongerude, Jane; Ansell, Christopher K.

    2011-01-01

    ited the power of political actors and depressed politicalan important new political actor, the Metropolitan Mayorsthese powerful political actors enhanced the possibilities

  2. Increasing State Capacity Through Clans

    E-Print Network [OSTI]

    Doyle, Jr, Thomas Martin

    2009-01-01

    party. In reality, political actors serving in any of theidentified goals and those political actors in positions ofInterviewing mainstream political actors in a metropolitan

  3. Where the Heart Is? A Geographic Analysis of Working-class Cultures in Detroit Neighborhoods, 1953

    E-Print Network [OSTI]

    Stepan-Norris, Judith; Southworth, Caleb

    2000-01-01

    Peterson 1954. City of Detroit Election Commission. 1952.Precinct Level. Microfilm. Detroit City Hall. Clawson, Dan.You!" Footnotes 24:1,4. Detroit Metropolitan Area Traffic

  4. Occupant Emergency Plans | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    documents for the Department of Energy, Headquarters buildings, in the Washington, DC, metropolitan area. Emergency Procedures Pamphlets Building Evacuation Routes Occupant...

  5. Clean Cities: Greater New Haven Clean Cities coalition

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    alternative vehicle and fuel consultation and assistance to many organizations in Connecticut and outside the state, including several towns and cities, metropolitan transit...

  6. Tobacco Control in Transition: Public Support and Governmental Disarray in Arizona 1997-2007

    E-Print Network [OSTI]

    Hendlin M.Sc., Yogi H.; Barnes, Richard L JD; Glantz, Stanton A. Ph.D.

    2008-01-01

    2002. Morris D. "East & West Valley Voters Support Smokefreebecame the first city in the West Valley of the metropolitanTGen) Arizona Heart Institute West Valley Hospital Arizona

  7. Marginalized Monitoring: Adaptively Managing Urban Stormwater

    E-Print Network [OSTI]

    Scanlan, Melissa K; Tai, Stephanie

    2013-01-01

    is heavily polluted by stormwater runoff from metropolitanMaroochy River, many near stormwater pipes. Human-specificFramework for Municipal Stormwater .. 17   B. The Federal

  8. Contending with illness in ancient Egypt: A textual and osteological study of health care at Deir el-Medina

    E-Print Network [OSTI]

    Austin, Anne

    2014-01-01

    Bioarchaeology of Ancient Egypt and Nubia: A Bibliography.of Medicine in Ancient Egypt. New York: Metropolitan MuseumPyramid Builders of Ancient Egypt: A Modern Investigation of

  9. Department of Energy Announces Quadrennial Energy Review Public...

    Broader source: Energy.gov (indexed) [DOE]

    Special Assistant to the President for Energy and Climate Change WHERE Metropolitan State University of Denver, Auraria Campus St. Cajetan's Center 1190 9th Street Denver, CO 80204...

  10. Tax Credits, Rebates & Savings | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Fuel Cells using Renewable Fuels Tax Credits, Rebates & Savings Tax Credits, Rebates & Savings Metropolitan Edison Company SEF Grants (FirstEnergy Territory) Examples of...

  11. Technical Report Documentation Page 1. Report No.

    E-Print Network [OSTI]

    and metropolitan areas. Economists have also predicted that oil prices will rise in real terms during the same and metropolitan areas. Economists have also predicted that oil prices will rise in real terms during the same. The research determined that the additional cost (with current prices) of the hybrid refuse truck was justified

  12. Motor Transport Co. 

    E-Print Network [OSTI]

    Unknown

    2011-09-05

    METROPOLITAN TRANSPORTATION PLAN Prepared by: The Longview Metropolitan Planning Organization In cooperation with: o City of Longview o City of White Oak o Gregg County o Harrison County o Texas Department of Transportation o U.S. Department... of Transportation o Federal Highway Administration o Federal Transit Administration Adopted November 12, 2009 TRANSPORTATION 2035 TABLE OF CONTENTS INTRODUCTION...

  13. Puzzle (4) 

    E-Print Network [OSTI]

    2012-03-05

    stream_source_info Alexandria_Pineville Metropolitan Transportation Plan MTP 2029.pdf.txt stream_content_type text/plain stream_size 90 Content-Encoding ISO-8859-1 stream_name Alexandria_Pineville Metropolitan Transportation Plan MTP...

  14. 2007 Telecommunications Policy Research Conference (TPRC) Finding an Effective Sustainable Model for a Wireless

    E-Print Network [OSTI]

    Peha, Jon M.

    , Associate Director of the Center for Wireless & Broadband Networking, Professor of Electrical Engineering for a Wireless Metropolitan-Area Network: Analyzing the Case of Pittsburgh1 J. M. Peha2 , B. E. Gilden3 , R. J to facilitate the deployment of a wireless metropolitan-area network (WiMAN) based on wifi technology. City

  15. PROTON BEAM REQUIREMENTS FOR A NEUTRINO FACTORY AND MUON COLLIDER

    E-Print Network [OSTI]

    Zisman, Michael S.

    2010-01-01

    Table 1 summarizes the NF proton driver parameters obtainedboth facilities. Table 1. Proton driver requirements for arepetition frequency (Hz) Proton energy (GeV) Proton rms

  16. ER85357_Phase2_Eltron | netl.doe.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    a proprietary, high-temperature nanofiltration (NF) technology (DurafluxTM) to remove salt and other dissolved solids from produced water originating from domestic oil and gas...

  17. Multicasting in Large Random Wireless Networks: Bounds on the Minimum Energy per Bit

    E-Print Network [OSTI]

    Verdú, Sergio

    was supported in part by the Office of Naval Research under contract numbers W911NF-07-1-0185 and N00014-07-1-0555

  18. 4786 IEEE TRANSACTIONS ON INFORMATION THEORY, VOL. 55, NO. 10, OCTOBER 2009 Probabilistic Coherence and Proper Scoring Rules

    E-Print Network [OSTI]

    Fitelson, Branden

    by the Office of Naval Research under Contracts W911NF-07-1-0185 and N00014-07-1-0555. J. B. Predd is with RAND

  19. Minimum Energy per Bit for Gaussian Broadcast Channels with Common Message and Cooperating

    E-Print Network [OSTI]

    Verdú, Sergio

    by the Office of Naval Research under contract numbers W911NF-07-1-0185 and N00014-07-1-0555. The minimum energy

  20. Energy-Distortion Tradeoff with Multiple Sources and Feedback

    E-Print Network [OSTI]

    Verdú, Sergio

    00014-07-1-0555, and the U.S. Army Research Ofce under Grant W911NF-07-1-0185. xed bandwidth ratio, we

  1. Control of size and charge selectivity in amphiphilic graft copolymer nanofiltration membranes

    E-Print Network [OSTI]

    Lovell, Nathan Gary

    2010-01-01

    The throughput and efficiency of membrane separations make polymer filtration membranes an important resource for the pharmaceutical, food and wastewater treatment industries. Nanofiltration (NF) membranes fill an important ...

  2. Dartmouth College HANOVER NEW HAMPSHIRE 03755-3586 Office of Pluralism and Leadership, Native American Program

    E-Print Network [OSTI]

    _campaign=DartmouthNAP&utm_content=157886900294782 976&ref=nf Registrar's Office Link to the ORC http://dartmouth.smartcatalogiq.com/2012/orc

  3. ISSN 1028-3358, Doklady Physics, 2006, Vol. 51, No. 10, pp. 569573. Pleiades Publishing, Inc., 2006. Original Russian Text E.A. Ivanova, D.A. Indeoetsev, N.F. Morozov, 2006, published in Doklady Akademii Nauk, 2006, Vol. 410, No. 6, pp. 754758.

    E-Print Network [OSTI]

    Ivanova, Elena A.

    investigation. In this paper, we discuss subtle features arising when such a method is applied in studying at the microscopic and macroscopic levels. In [1, 2], as an example, the dependences of both the Young modulus and the bending rigidities of samples were theoretically investigated for a two-dimensional single-crystal bar

  4. Research on Hakka Word Segmentation Processes in ChinesetoHakka TexttoSpeech System

    E-Print Network [OSTI]

    .66 40.67 30.87 26.65 33.04 33.04 1. 2.3.4.5. (Nep) (Nf) (Nc) (DE) (Na) (D) (VH) (COMMACATEGORY) (D) (VH) (VC) (Nc) (PERIODCATEGORY) (Nep) (Nf) (Nc) (DE) (Na) (D) (VH) (COMMACATEGORY) (D) (VH

  5. Genotoxicity of complex chemical mixtures 

    E-Print Network [OSTI]

    Phillips, Tracie Denise

    2009-05-15

    non-aqueous phase liquid from a wood treatment plant was separated into acid (AF), base (BF) and neutral fractions (NF). The NF was further enriched using column chromatography to produce a polychlorinated dinbenzo-p-dioxin (PCDD) and a polycyclic...

  6. 782 A. Y. KAPLAN ET AL. SOFIA U. TARASOVA

    E-Print Network [OSTI]

    Kaplan, Alexander

    (NF), but were guided only to look at the computer screen. It was found that during such unconscious-computer interface (BCI), color perception, electroencepha- logram (EEG), neurofeedback (NF), RGB model, spectral of many disabled people by the use of an available power computer. #12;UNCONSCIOUS OPERANT CONDITIONING

  7. High Flash-point Fluid Flow System Aerosol Flammability Study and Combustion Mechanism Analysis 

    E-Print Network [OSTI]

    Huang, Szu-Ying

    2013-12-02

    regions of three main, widely-used commercial heat transfer fluids: Paratherm NF (P-NF); Dowtherm-600 (D-600); and Plate Heat Exchange Fluid (PHE), were analyzed by electro-spray generation with laser diffraction particle analysis method. The aerosol...

  8. Harold G. Kirk Brookhaven National Laboratory

    E-Print Network [OSTI]

    McDonald, Kirk

    Harold G. Kirk Brookhaven National Laboratory The IDS-NF Target Baseline IDS-NF Plenary Meeting Rutherford Appleton Lab September 20-25, 2010 #12;Harold G. Kirk 2 The Neutrino Factory Target Concept/GeV/interactingproton) - + Palmer, PAC97 #12;Harold G. Kirk 3 The Study 2 Target System Neutrino

  9. Dmarche qualit au sein d'un laboratoire de recherche du CNRS: FEMTO-ST

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    également lancés dans la mise en place de la norme NF EN ISO 9001 afin d'obtenir une certification décennies des laboratoires accrédités par le COFRAC selon le référentiel NF EN ISO/CEI 17025. Ainsi, le : recherche, qualité, laboratoires, label Carnot, ISO 9001, ISO/CEI 17025, Université de Franche-Comté, FEMTO

  10. A study of open payment fare systems : system design, fare engine algorithm and GTFS extension

    E-Print Network [OSTI]

    Wang, Yin, S.M. Massachusetts Institute of Technology

    2014-01-01

    This thesis describes the design and implementation of the key parts of an open payment system that supports mobile phone ticketing for the Long Island Railroad (LIRR), a part of the New York Metropolitan Transportation ...

  11. Optimal Urban Population Size: National vs Local Economic Efficiency

    E-Print Network [OSTI]

    Nam, Kyung-min

    This paper explores whether the population size of the Seoul Metropolitan Area (SMA) in Korea is efficient in terms of the national economy. To undertake this analysis, a recursively dynamic interregional computable general ...

  12. Neighborhood, City, or Region: Deconstructing Scale in Planning Frames

    E-Print Network [OSTI]

    Lowe, Kate

    2011-01-01

    and the California High-Speed Rail Authority) Fischer,have implications for the federal high-speed rail program.Interstate program, high-speed rail may have metropolitan

  13. Assessment of the potential diversion of air passengers to high-speed rail in the northeast corridor

    E-Print Network [OSTI]

    Clarke, Michael D. D.

    1994-01-01

    The high level of intercity passenger travel in the Northeast Corridor is supported by densely populated metropolitan city-centers, the suitable distance between the urban areas, and the extent to which economic and social ...

  14. Publications of the Hawaii Institute of Geophysics and Planetology University of Hawaii

    E-Print Network [OSTI]

    (2011). Seismicity around the Hawaiian Islands Recorded by the PLUME Seismometer Networks: Insight of summer heat waves in the Paris metropolitan area. International Journal of Climatology, 31: 313­323. doi

  15. Emergence of secondary airports and dynamics of regional airport systems in the United States

    E-Print Network [OSTI]

    Bonnefoy, Philippe A

    2005-01-01

    With the growing demand for air transportation and limited capacity at major airports, there is a need to increase the capacity of airport systems at the metropolitan area level. The increased use of secondary airports has ...

  16. 11.380J / 1.252J / ESD.225J Urban Transportation Planning, Fall 2002

    E-Print Network [OSTI]

    Salvucci, Frederick

    This class is an introduction to planning transportation in metropolitan areas. The approach, while rooted on the analytical tools which estimate outcomes and alternatives, is holistic. This means starting from ...

  17. Female community leaders in Houston, Texas: a study of the education of Ima Hogg and Christia Daniels Adair 

    E-Print Network [OSTI]

    Black, Linda L.

    2009-05-15

    Houston, Texas, the fourth largest metropolitan area in the United States, has several structures named after historically male leaders of the city?George R. Brown Convention Center, Mickey Leland Federal Building, William ...

  18. Preliminary Analysis of Energy Consumption For Cool Roofing Measures

    E-Print Network [OSTI]

    Wang, Xiaorui "Ray"

    was the result of studies performed in the 1980's establishing a phenomenon known as the urban heat island effect. As best described, the urban heat island effect is the thermal property of metropolitan areas to remain

  19. Mexican Internal and International Migration: Empirical Evidence from Related Theories

    E-Print Network [OSTI]

    von Scheven, Elsa Beatrice

    2015-01-01

    H. , and C. Defoort 2009 “Inequality and the Self-SelectionCompanion to Social Inequalities. Ed. M. Romero and E.Sources of Racial Wage Inequality in Metropolitan Labor

  20. What happened to the three-decker?

    E-Print Network [OSTI]

    Wegmann, Jacob (Jacob G.)

    2006-01-01

    This thesis examines the three-decker, a type of small apartment house ("superposed flats") that is common in the Boston metropolitan region and elsewhere in New England. The three-decker is distinctive in two ways: its ...

  1. Short Bio of Naomi Angel Naomi Angel, Architect, M.Sc.

    E-Print Network [OSTI]

    Sadeh, Norman M.

    Planner (one of 6 Districts in Israel). Primary projects: Metropolitan Comprehensive Plan, Business in Public Uses ­ guide and & Directives High-rise Buildings - Planning Directives 2004 Urban Design Planning bureau consists of 25 professionals: Architects, Planners, Specific advisors ­ assessment

  2. Laboratory characterization of a highly weathered old alluvium in San Juan, Puerto Rico

    E-Print Network [OSTI]

    Zhang, Guoping, 1968-

    2002-01-01

    The old alluvium underlying much of metropolitan San Juan was formed in early Pleistocene and has undergone substantial post-depositional weathering in the tropical climate of Puerto Rico, resulting in a special combination ...

  3. An overview of the MILAGRO 2006 Campaign: Mexico City emissions and their transport and transformation

    E-Print Network [OSTI]

    Molina, Luisa Tan

    MILAGRO (Megacity Initiative: Local And Global Research Observations) is an international collaborative project to examine the behavior and the export of atmospheric emissions from a megacity. The Mexico City Metropolitan ...

  4. Residential property values and neighborhood retail : a comparison of pedestrian and automobile oriented retail clusters

    E-Print Network [OSTI]

    Tiffany, Thacher

    2006-01-01

    This study tests the hypothesis that home buyers pay a premium to live within walking distance of pedestrian accessible retail. To answer this question two types of retail clusters are identified in the Boston metropolitan ...

  5. Art History and the Invention of Botticelli

    E-Print Network [OSTI]

    Melius, Jeremy Norman

    2010-01-01

    Zerner, Henri. “Giovanni Morelli et la science de l’art. ”Revue de l’Art 40-41 (1978): Zola, Émile. Rome. Paris: G.cm. Metropolitan Museum of Art, New York. Fig. 16: Detail of

  6. Modeled and observed ozone sensitivity to mobile-source emissions in Mexico City

    E-Print Network [OSTI]

    Zavala, M.

    The emission characteristics of mobile sources in the Mexico City Metropolitan Area (MCMA) have changed significantly over the past few decades in response to emission control policies, advancements in vehicle technologies ...

  7. Comparison of aromatic hydrocarbon measurements made by PTR-MS, DOAS and GC-FID during the MCMA 2003 Field Experiment

    E-Print Network [OSTI]

    Jobson, B. T.

    A comparison of aromatic hydrocarbon measurements is reported for the CENICA supersite in the district of Iztapalapa during the Mexico City Metropolitan Area field experiment in April 2003 (MCMA 2003). Data from three ...

  8. Evaluation of WRF mesoscale simulations and particle trajectory analysis for the MILAGRO field campaign

    E-Print Network [OSTI]

    de Foy, B.

    Accurate numerical simulations of the complex wind flows in the Mexico City Metropolitan Area (MCMA) can be an invaluable tool for interpreting the MILAGRO field campaign results. This paper uses three methods to evaluate ...

  9. Impacts of residential developments on local sustainability : case study in Metro Boston

    E-Print Network [OSTI]

    Xia, Jie, M.C.P. Massachusetts Institute of Technology

    2011-01-01

    Along with urbanization and decentralization, the sustainability of metropolitan areas is considered one of the most significant challenges worldwide. Transportation-related problems, such as congestion, GHG emissions, and ...

  10. South Carolina Clean Energy Summit | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    3, 2015 8:00AM to 5:00PM EDT Metropolitan Convention Center Columbia, South Carolina The South Carolina Clean Energy Business Alliance will host the fourth annual Clean Energy...

  11. CX-004443: Categorical Exclusion Determination

    Office of Energy Efficiency and Renewable Energy (EERE)

    State Energy Program - Combined Heat and Power - Metropolitan CouncilCX(s) Applied: B5.1Date: 11/16/2010Location(s): MinnesotaOffice(s): Energy Efficiency and Renewable Energy, Golden Field Office

  12. Weekly

    U.S. Energy Information Administration (EIA) Indexed Site

    the four metropolitan areas monitored by this report (Atlanta, Chicago, Houston and New York City) were cooler than normal most days last week. This was especially true in Chicago...

  13. Environmental impacts of the digital economy: The case of Austin, Texas, 1990-2008 

    E-Print Network [OSTI]

    Tu, Wei

    2005-08-29

    This dissertation investigates the dynamic economic structure transformation and its corresponding environmental consequences at the Austin-San Marcos Metropolitan Statistical Area (Austin MSA) from 1990 to 2008. Input-output (IO) analysis...

  14. Orchard 

    E-Print Network [OSTI]

    2009-01-01

    spatially explicit cellular automata model, to simulate future (2002-2030) urban growth in the Houston metropolitan area, one of the fastest growing metropolises in the United States during the past decades. The model is calibrated with historical data...

  15. Political Fragmentation and Its Effects on Residential Segregation 

    E-Print Network [OSTI]

    Amaro, Gabriel Hernandez

    2013-11-25

    In this thesis, I investigate the relationship between black-white residential segregation in U.S. metropolitan areas, and the amount of political fragmentation within the metro area. Using the dissimilarity index calculated ...

  16. If you reside in WASHINGTON, DC - MD -VA - WV your salary will...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    If you are employed in the WASHINGTON, DC Metropolitan Area (D.C., Baltimore, Northern VA, Eastern WV, and Southern PA) your salary will range from: Pay Band Pay Plan(s) Minimum...

  17. Evaluation of mobile emissions contributions to Mexico City's emissions inventory using on-road and cross-road emission measurements and ambient data

    E-Print Network [OSTI]

    Zavala-Perez, Miguel Angel

    Mobile emissions represent a significant fraction of the total anthropogenic emissions burden in the Mexico City Metropolitan Area (MCMA) and, therefore, it is crucial to use top-down techniques informed by on-road exhaust ...

  18. Game theory and real options : analysis of land value and strategic decisions in real estate development

    E-Print Network [OSTI]

    So, Chun Kit (Chun Kit Timothy)

    2013-01-01

    This thesis investigates the use of the game theory and the real options theory in real estate development at the strategic level, trying empirically to explain different economic observations among different metropolitan ...

  19. Land development approaches in the context of land scarcity : case study, Byblos, Lebanon

    E-Print Network [OSTI]

    Asdourian, Avedis

    1986-01-01

    The objective of this study is to provide a general understanding for guiding urban development in secondary cities in Lebanon. An existing site in the Byblos Metropolitan Area is utilized as a reference to this study. The ...

  20. Atmos. Chem. Phys., 11, 1316113179, 2011 www.atmos-chem-phys.net/11/13161/2011/

    E-Print Network [OSTI]

    Meskhidze, Nicholas

    Mediterranean forest site near the metropolitan area of Barcelona (NE Iberian Peninsula). Methanol was the most abundant compound among all the VOCs mea- sured in both seasons. While aromatic VOCs showed al- most

  1. Introduction to Transportation Planning

    E-Print Network [OSTI]

    Tipple, Brett

    Introduction to Transportation Planning CMP 4710/6710 Fall 2012 3 Credit Hours Room: ARCH 229 of City & Metropolitan Planning; Associate Dean, College of Architecture + Planning; former associate, social equity, fiscal health, and public health. Unfortunately, most transportation planning processes

  2. Comprehensive Regional Goods Movement Plan and Implementation Strategy

    E-Print Network [OSTI]

    California at Davis, University of

    Comprehensive Regional Goods Movement Plan and Implementation Strategy ON THE MOVE Southern? Nation's largest Metropolitan Planning Organization (MPO) and Council of Governments (COG) 6 counties and Warehousing, $22 Utilities, $10 Mining, $3 Forestry, Fishing, Related Activities and Other, $- 4 Manufacturing

  3. THE GREATER TORONTO AREA TRAVEL DEMAND MODELLING SYSTEM

    E-Print Network [OSTI]

    Toronto, University of

    by the then Metropolitan Toronto Planning Department and the Ministry of Transportation, Ontario. Support and advice Post-Run Report 32 4.5 Base 1996 Files for Use in Post-Run Utilities 33 #12;GTA Travel Demand Modelling

  4. Urban Reclamation in São Paulo

    E-Print Network [OSTI]

    Eskinazi, Victor

    2009-01-01

    The urbanized terrain of São Paulo is characterized by wasteful landscapes on peripheral areas of the metropolitan agglomeration, and decaying landscapes of waste in the core of the city. If on the one hand, the increasingly ...

  5. Can Federal Funding Create Bicycle Friendly Cities? A Comparative Study of Bicycle Planning in Sacramento and Amsterdam

    E-Print Network [OSTI]

    2007-01-01

    of Bicycle Planning in Sacramento and Amsterdam KATHRYN M.as a model of how the Sacramento region can achieve highis on the area within Sacramento’s Metropolitan Planning

  6. Weather and emotional state: a search for associations between weather and calls to telephone counseling services 

    E-Print Network [OSTI]

    Stillman, Daniel Noah

    2000-01-01

    Calls to four telephone counseling services, or "hotlines", each serving communities in a major metropolitan area of the United States (Detroit, Washington DC, Dallas and Seattle), were analyzed for influence from daily weather. Associations...

  7. Innovation Systems and Learning Processes in the EU and US Regions

    E-Print Network [OSTI]

    Runiewicz-Wardyn, Malgorzata

    2009-01-01

    Santa Clara, Seattle-Tacoma-Bellevue and the metropolitanWarren-Livonia, US Seattle-Tacoma-Bellevue, US West, SwedenArden-Arcade-- Seattle-Tacoma-Bellevue, US Denver-Aurora, US

  8. A Novel Technology for the Reduction of NOx on Char by Microwaves 

    E-Print Network [OSTI]

    Buenger, C.; Peterson, E.

    1994-01-01

    The emphasis on reduction of NOx as a precursor to street level ozone has increased the need for technologies capable of reducing NOx (>95%) to very low levels in major metropolitan areas from a wide variety of sources. Technology offerings...

  9. Characterization of submicron aerosols at a rural site in Pearl River Delta of China using an Aerodyne High-Resolution Aerosol Mass Spectrometer

    E-Print Network [OSTI]

    Kroll, Jesse

    The Pearl River Delta (PRD) region in South China is one of the most economically developed regions in China, but it is also noted for its severe air pollution due to industrial/metropolitan emissions. In order to continuously ...

  10. Hit from both sides: tracking industrial and volcanic plumes in Mexico City with surface measurements and OMI SO2 retrievals during the MILAGRO field campaign

    E-Print Network [OSTI]

    de Foy, B.

    Large sulfur dioxide plumes were measured in the Mexico City Metropolitan Area (MCMA) during the MILAGRO field campaign. This paper seeks to identify the sources of these plumes and the meteorological processes that affect ...

  11. Contribution of garbage burning to chloride and PM[subscript 2.5] in Mexico City

    E-Print Network [OSTI]

    Li, G.

    The contribution of garbage burning (GB) emissions to chloride and PM[subscript 2.5] in the Mexico City Metropolitan Area (MCMA) has been investigated for the period of 24 to 29 March during the MILAGRO-2006 campaign using ...

  12. West Virginia Business & Economic Review, Winter 2012 1 West Virginia

    E-Print Network [OSTI]

    Mohaghegh, Shahab

    Morgantown's prices. Utilities, which include electric, natural gas, and land-line telephone services, were 2 Metropolitan Area Composite Index (100%) Grocery Items (13%) Housing (29%) Utilities (10%) Transportation (9

  13. Economic costs of conventional surface-water treatment: A case study of the Mcallen northwest facility 

    E-Print Network [OSTI]

    Rogers, Callie Sue

    2009-05-15

    Conventional water treatment facilities are the norm for producing potable water for U.S. metropolitan areas. Rapidly-growing urban populations, competing demands for water, imperfect water markets, and uncertainty of ...

  14. The Migration Industry: Brokering Mobility in the Mexico-U.S. Migratory System

    E-Print Network [OSTI]

    Hernandez-Leon, Ruben

    2013-01-01

    Epic Story of the Great Migrations that Made the AmericanR. F. “The Commerce of Migration. ” Canadian Ethnic Studies/Metropolitan Migrants: The Migration of Urban Mexicans to

  15. Impact of the Miami 21's parking requirements on the real estate developments in the city of Miami

    E-Print Network [OSTI]

    Libman, Rafael

    2014-01-01

    In the last years, Fort Lauderdale, West Beach, and Miami together became the 8th largest metropolitan area in the U.S. with a population of approximately 6 million people. During the last four years the population of such ...

  16. Ozone predictabilities due to meteorological uncertainties in the Mexico City basin using ensemble forecasts

    E-Print Network [OSTI]

    Bei, Naifang

    The purpose of the present study is to investigate the sensitivity of ozone (O3)[(O subscript 3)] predictions in the Mexico City Metropolitan Area (MCMA) to meteorological initial uncertainties and planetary boundary layer ...

  17. QGESS: Specification for Selected Feedstocks

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in Exhibit 1-1, which is based on the mean of over 6,800 samples of pipeline quality natural gas taken in 26 major metropolitan areas of the United States (U.S.). 1 Exhibit 1-1...

  18. Evaluation of access management on urban arterial streets using TRAF-NETSIM 

    E-Print Network [OSTI]

    Irizarry Gutierrez, Nelson

    1995-01-01

    The increasing congestion problems faced by most metropolitan areas have resulted in the search for new ways to control the traffic congestion problem. Most cities have relied for years in the addition of new lanes to ...

  19. Oxidative capacity of the Mexico City atmosphere - Part 1: A radical source perspective

    E-Print Network [OSTI]

    Volkamer, R.

    A detailed analysis of OH, HO2 [HO subscript 2] and RO2 [RO subscript 2] radical sources is presented for the near field photochemical regime inside the Mexico City Metropolitan Area (MCMA). During spring of 2003 (MCMA-2003 ...

  20. Ozone response to emission changes: a modeling study during the MCMA-2006/MILAGRO Campaign

    E-Print Network [OSTI]

    Song, Jihee

    The sensitivity of ozone production to precursor emissions was investigated under five different meteorological conditions in the Mexico City Metropolitan Area (MCMA) during the MCMA-2006/MILAGRO field campaign using the ...

  1. Measurements of OH and HO2 concentrations during the MCMA-2006 field campaign – Part 2: Model comparison and radical budget

    E-Print Network [OSTI]

    Dusanter, S.

    Measurements of hydroxyl (OH) and hydroperoxy (HO2) radicals were made during the Mexico City Metropolitan Area (MCMA) field campaign as part of the MILAGRO (Megacity Initiative: Local and Global Research Observations) ...

  2. Cost-effective optical network architecture : a joint optimization of topology, switching, routing and wavelength assignment

    E-Print Network [OSTI]

    Guan, Kyle Chi

    2007-01-01

    To provide end users with economic access to high bandwidth, the architecture of the next generation metropolitan area networks (MANs) needs to be judiciously designed from the cost perspective. In addition to a low initial ...

  3. Application of positive matrix factorization to on-road measurements for source apportionment of diesel- and gasoline-powered vehicle emissions in Mexico City

    E-Print Network [OSTI]

    Thornhill, D. A.

    The goal of this research is to quantify diesel- and gasoline-powered motor vehicle emissions within the Mexico City Metropolitan Area (MCMA) using on-road measurements captured by a mobile laboratory combined with positive ...

  4. "For good design, you pay now; for bad design, you pay later"--or do you?

    E-Print Network [OSTI]

    Murugappan, Meena

    2006-01-01

    What is the value of architectural design on office building income? This empirical study of 296 office building located in 11 Metropolitan Statistical Areas (MSA) hopes to quantitatively determine if a plain vanilla cereal ...

  5. Directions to East Hall: I-94 (Ford Freeway)

    E-Print Network [OSTI]

    Jonides, John

    Directions to East Hall: I-94 (Ford Freeway) From Detroit and the Detroit Metropolitan on your right. I-96 (also called the Jeffries Freeway) From Parts of Detroit, Redford, M-14, Plymouth

  6. Detroit folio : Wayne, Detroit, Grosse Pointe, Romulus, and Wyandotte quadrangles, Michigan 

    E-Print Network [OSTI]

    Sherzer, W. H. (William Hittell), 1860-1932.

    1917-01-01

    Calls to four telephone counseling services, or "hotlines", each serving communities in a major metropolitan area of the United States (Detroit, Washington DC, Dallas and Seattle), were analyzed for influence from daily weather. Associations...

  7. A flexible infra-architectural system for a Hybrid Shanghai

    E-Print Network [OSTI]

    Luna, Rafael (Rafael Alberto)

    2010-01-01

    The increasing migration from a rural to an urban setting has lead to a rapid expansion of metropolitan areas around world (50% of the world population lives in cities). The demand for living and working spaces inside the ...

  8. Factor Prices in Egypt from 1900 to World War II with International Comparisons

    E-Print Network [OSTI]

    Hansen, Bent

    1989-01-01

    av. , Cigarette Laborers, industry Egypt: Metropolitan OtherBusiness: Rate of Profits Egypt and United States (percent)n. a. n .a. CG LO Rates, Egypt, Visible profit Rates, % of

  9. The Role of Climatic and Environmental Variability on West Nile Virus in Harris County, Texas, 2006-2007 

    E-Print Network [OSTI]

    Berhane, Stephen

    2010-07-14

    Between the years 2006-2007, Harris County, located at the heart of the Houston metropolitan area, experienced a nearly 90% decline in the number of female mosquitoes which tested positive for the West Nile virus. Different ...

  10. Modeling the impacts of biomass burning on air quality in and around Mexico City

    E-Print Network [OSTI]

    Lei, W.

    The local and regional impacts of open fires and trash burning on ground-level ozone (O[subscript 3]) and fine carbonaceous aerosols in the Mexico City Metropolitan Area (MCMA) and surrounding region during two high fire ...

  11. Vehicle Technologies Office Merit Review 2014: Mid-America Collaborative for Alternative Fuels Implementation

    Broader source: Energy.gov [DOE]

    Presentation given by Metropolitan Energy Center, Inc. at 2014 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Office Annual Merit Review and Peer Evaluation Meeting about Mid-America...

  12. AN ASSESSMENT OF THE USE OF POTOMAC ESTUARY WATERS AND AWT

    E-Print Network [OSTI]

    District of Columbia, University of the

    of upland dams to supply future metropolitan water needs. A result of this resistance is a heightened 25 V. SUMMARY CONCLUSIONS AND RECOMMENDATIONS 27 SELECTED REFERENCES 31 LIST OF TABLES 1. VIRUS

  13. GIS-based modeling approaches to identify mitigation placement along roads

    E-Print Network [OSTI]

    Clevenger, Anthony P.; Wierzchowski, Jack

    2001-01-01

    and K. Gunson. In press. GIS-generated expert based modelsJ.M and R.M. Itami. 1991. GIS-based habitat modeling usingsuitability assessment – A GIS approach. Bombay Metropolitan

  14. Town of Airfield : creating a prototype for suburban development at the Naval Air Station site in South Weymouth

    E-Print Network [OSTI]

    Panfil, J. Christoph

    1996-01-01

    The accumulation of negative externalities associated with the rapid expansion of many metropolitan areas in the United States suggests that the current suburban development model is no longer a viable option for efficiently ...

  15. The Elsevier Foundation Awards for Early-Career Researchers in Developing Countries 2015

    E-Print Network [OSTI]

    The Elsevier Foundation Awards for Early-Career Researchers in Developing Countries 2015 Physics Mandela Metropolitan University (NMMU). Her current research focuses on development of titanium oxide and climate parameters, atmospheric radioactivity and electricity and lightning and food security using

  16. Educational Human-computer Debate: a Computational Dialectics Approach

    E-Print Network [OSTI]

    Grasso, Floriana

    and reflection ([15], ¡ School of computing, Leeds Metropolitan University, Leeds, LS6 3QS, United Kingdom [16 in educational contexts in particular. We therefore review two approaches to characterising dia- logue types

  17. Aerosol plume transport and transformation in high spectral resolution lidar measurements and WRF-Flexpart simulations during the MILAGRO Field Campaign

    E-Print Network [OSTI]

    de Foy, B.

    The Mexico City Metropolitan Area (MCMA) experiences high loadings of atmospheric aerosols from anthropogenic sources, biomass burning and wind-blown dust. This paper uses a combination of measurements and numerical ...

  18. Flexible urbanism

    E-Print Network [OSTI]

    Anandam, Anahita

    2006-01-01

    This thesis seeks to find a new approach/method towards urbanization in existing low density neighborhoods in major metropolitan cities in the United States. The near South side of the city of Chicago (a city that carries ...

  19. Opportunities for Energy Efficiency and Open Automated Demand Response in Wastewater Treatment Facilities in California -- Phase I Report

    E-Print Network [OSTI]

    Lekov, Alex

    2010-01-01

    for Wineries- Energy Management East Bay Municipal UtilityWastewater Process Energy, Case Studies: East Bay MunicipalEast Bay Municipal Utilities District Metropolitan Water District Methodology for Analysis of Energy

  20. State and Regional Energy Risk Assessment Initiative | Department...

    Office of Environmental Management (EM)

    During the Winters of 2013-2014 and 2014-2015 Energy Risk Predictions for the 2015 Hurricane Season Effect of Sea Level Rise on Energy Infrastructure in Four Major Metropolitan...

  1. Managing the implementation of automotive emission control technologies using systems engineering principles

    E-Print Network [OSTI]

    Penney, John, 1974-

    2004-01-01

    In the 1940s and 1950s poor air quality in major metropolitan areas throughout the United States started to negatively influence the health of citizens throughout the country. After numerous studies the government concluded ...

  2. ASPECTS OF PARTIAL INFORMATION IN DATABASES Leonid Libkin

    E-Print Network [OSTI]

    Libkin, Leonid

    {c7 38. Kg4{f5 Nf6:d5+ 13. h2{h3? Bc8{d7 39. Kf5{g4 Nd5{f6+ 14. Rb1{c1 g7{g6 40. Kg4{f5 Nf6{g8+ 15. Nf3{d2 Ra8{b8 41. Kf5{g4 Ng8{f6+ 16. Nd2{b3 Nc5:b3 42. Kg4{f5 Nf6{g8+ 17. Qc2:b3 c6{c5 43. Kf5{g4 Be7:g5 18. Kg1{h2 Kg8{h8 44. Kg4:g5 Rf8{f7 19. Qb3{c2 Nf6{g8 45. Bf2{h4 Rh6{g6+ 20. Be2{g4 Ng8{h6 46. Kg

  3. First order switched-capacitor building blocks for analog circuits 

    E-Print Network [OSTI]

    Nguyen, Liem Thanh

    1983-01-01

    switches. (a. ) Circuit schematic and, (b. ) the resulting two-phase clock signals. 29 13 Magnitude response of the stray sensitive configuration with V3 connected to V and V2 grounded. Cl 4. 591nF, 0 C3=255. 4pF, and C4 14. 7nF, 31 14 Phase response... of the stray sensitive configuration with V3 connected to V and V2 grounded . C 1 =4 . 5 91 nF 0 C3=255. 4pP, and C4=14. 7nF. 32 15 Magnitude response of the stray sensitive configuration with V3 connected to VO and Vl grounded. Cp4. 591nF, C3=255. 4p...

  4. Monroe Urbanized Area MTP 2035 

    E-Print Network [OSTI]

    Monroe Urbanized Area Metropolitan Planning Organization

    2010-10-31

    /plain; charset=ISO-8859-1 Monroe Urbanized Area MTP 2035 The 2035 Metropolitan Transportation Plan for the Monroe Urbanized Area Developed for The Monroe Urbanized Area Metropolitan Planning Organization and The Louisiana Department... of Transportation and Development Developed by In association with Neel-Schaffer, Inc. **DRAFT** Adopted Date Here This document was prepared in cooperation with: The Monroe Urbanized Area MPO Technical Advisory Committee and The Louisiana...

  5. Influence of the Torsion Angle in 3,3'-Dimethyl-2,2'-bipyridine on the Intermediate Valence of Yb in (C5Me5)2 Yb(3,3'-Me2-bipy)

    SciTech Connect (OSTI)

    Nocton, Gré gory; Booth, Corwin H.; Maron, Laurent; Andersen, Richard A.

    2014-06-26

    The synthesis and X-ray crystal structures of Cp-2*Yb(3,3'-Me(2)bipy) and [Cp-2 Yb(3,3'-Me(2)bipy)][Cp-2 YbCl1.6I0.4]center dot CH2Cl2 are described. In both complexes, the NCCN torsion angles are approximately 40 degrees. The temperature-independent value of n(f) of 0.17 shows that the valence of ytterbium in the neutral adduct is multiconfigurational, in reasonable agreement with a CASSCF calculation that yields a n(f) value of 0.27; that is, the two configurations in the wave function are f(13)(pi(1))(1) and f(14)(pi(1))(0) in a ratio of 0.27:0.73, respectively, and the open-shell singlet lies 0.28 eV below the triplet state (n(f) accounts for f-hole occupancy; that is, n(f) = 1 when the configuration is f(13) and n(f) = 0 when the configuration is f(14)). A correlation is outlined between the value of nf and the individual ytterbocene and bipyridine fragments such that, as the reduction potentials of the ytterbocene cation and the free x,x'-R-2-bipy ligands approach each other, the value of nf and therefore the f(13):f(14) ratio reaches a maximum; conversely, the ratio is minimized as the disparity increases.

  6. Information strategies and energy conservation behavior: A meta-analysis of experimental studies from 1975 to 2012

    E-Print Network [OSTI]

    Delmas, MA; Fischlein, M; Asensio, OI

    2013-01-01

    use reminders, may render energy usage more salient and helpmore aware of their own energy usage may contribute toa relative increase in energy usage. art ic l e i nf o a b s

  7. Microsoft PowerPoint - Low Dose Update Metting 6 Dec 2012

    Broader source: Energy.gov (indexed) [DOE]

    Dose DOE's Low Dose R di ti R h R di ti R h Radiation Research Radiation Research Program Program g g NF Metting, Sc.D., Program Manager Nuclear Energy Advisory Committee Meeting...

  8. Politeness in Japanese Sign Language (JSL): Polite JSL expression as evidence for intermodal language contact influence

    E-Print Network [OSTI]

    George, Johnny Earl

    2011-01-01

    Do you mind’ Ni=#N= phrase initial nod F=chin-forward Nf=N#=phrase final nod O= O=ONEGAI ‘please’ E=polite grimacepoints to indicate, head nods and shakes to modulate their

  9. Design considerations for a solar-powered desalination system for remote communities in Australia 

    E-Print Network [OSTI]

    Richards, B.S.; Schäfer, Andrea

    2002-01-01

    Water in many areas of Australia is scarce and of poor quality. In some areas high levels of treatment are required either due to contamination of waters or due to high salinity. Nanofiltration (NF) and low-pressure reverse ...

  10. 1992 CBECS C & E

    U.S. Energy Information Administration (EIA) Indexed Site

    of Natural Gas by End Use, 1989 Natural Gas Consumption (trillion Btu) Space Water a Total Heating Heating Cooking Other RSE Building Row Characteristics Factor 1.0 NF...

  11. Systematic approach for simultaneously correcting the band-gap...

    Office of Scientific and Technical Information (OSTI)

    Number: Army W911NF-10-1-0524; AC02-05CH11231 Type: Publisher's Accepted Manuscript Journal Name: Physical Review. B, Condensed Matter and Materials Physics Additional Journal...

  12. gropuUCSB2013-07-30_Webinar.ppt

    Broader source: Energy.gov (indexed) [DOE]

    124345 1-D profile through NF PM2 Summary Cont. - APT Fe TA artifact L T 40115 kgmm 2 PM2 Summary Cont. - Tensile Strength Property L T * Excellent low transition...

  13. Anti-inflammatory Effect of Vigna Unguiculata Polyphenols in Raw 264.7 Macrophages 

    E-Print Network [OSTI]

    Siska, Karla P

    2013-04-29

    for phenolic content and composition using UV-Visible Spectroscopy and HPLC; antioxidant activation mechanism (AOX) by oxygen radical absorbance capacity (ORAC). Anti-inflammatory activity was measured via NF-?B activation in Raw 264.7 macrophages challenged...

  14. Indirect Determination of the 230Th(n,f) and 231Th(n,f) Cross Sections for Thorium-Based Nuclear Energy Systems

    E-Print Network [OSTI]

    Stroberg, S.R.

    2012-01-01

    n,f) Cross Sections for Thorium-Based Nuclear Energy Systemsf ) Cross Sections for Thorium-Based Nuclear Energy Systemsbenchmark- ing of advanced thorium-based nuclear reactor

  15. YEAR

    National Nuclear Security Administration (NNSA)

    300 YEAR 2011 Males 109 Females 191 YEAR 2011 SES 9 EJEK 1 NN (Engineering) 2 NQ (ProfTechAdmin) 203 NU (TechAdmin Support) 38 NF (Future Ldrs) 47 YEAR 2011 American Indian...

  16. YEAR

    National Nuclear Security Administration (NNSA)

    86 YEAR 2012 Males 103 Females 183 YEAR 2012 SES 7 EJEK 1 NN (Engineering) 1 NQ (ProfTechAdmin) 202 NU (TechAdmin Support) 30 NF (Future Ldrs) 45 YEAR 2012 American Indian Male...

  17. Adsorption of Estrone on nanofiltration and reverse osmosis membranes in water and wastewater treatment 

    E-Print Network [OSTI]

    Nghiem, D.L.; Schäfer, Andrea; Waite, T.D.

    2002-01-01

    Adsorption of the trace contaminant estrone, a natural hormone and commonly abundant in surface waters and in treated as well as untreated wastewaters, to eight commercial nanofiltration (NF) and reverse osmosis (RO) ...

  18. Renewable energy powered membrane technology. 2. The effect of energy fluctuations on performance of a photovoltaic hybrid membrane system 

    E-Print Network [OSTI]

    Richards, B.S.; Capão, D.P.S.; Schäfer, Andrea

    2008-01-01

    This paper reports on the performance fluctuations during the operation of a batteryless hybrid ultrafiltration – nanofiltration / reverse osmosis (UF-NF/RO) membrane desalination system powered by photovoltaics treating ...

  19. Impact of pH on the removal of fluoride, nitrate and boron by nanofiltration/reverse osmosis 

    E-Print Network [OSTI]

    Richards, Laura A.; Vuachère, Marion; Schäfer, Andrea

    2010-01-01

    The objective of this study was to evaluate the impact of pH on boron, fluoride, and nitrate retention by comparing modelled speciation predictions with retention using six different nanofiltration (NF) and reverse osmosis ...

  20. Thermal transition temperature from twisted mass QCD

    E-Print Network [OSTI]

    Florian Burger; Ernst-Michael Ilgenfritz; Malik Kirchner; Maria Paola Lombardo; Michael Müller-Preussker; Owe Philipsen; Carsten Urbach; Lars Zeidlewicz

    2010-09-20

    We present the current status of lattice simulations with N_f=2 maximally twisted mass Wilson fermions at finite temperature. In particular, the determination of the thermal transition temperature is discussed.