Sample records for nf metropolitan

  1. Metropolitan Transportation Plan 2035

    E-Print Network [OSTI]

    Tyler Area Metropolitan Planning Organization

    2009-12-04T23:59:59.000Z

    Adopted by the Tyler Area MPO Policy Committee December 4, 2009 METROPOLITAN TRANSPORTATION PLAN 2035 Revised April 22, 2010 Adopted by the Tyler Area MPO Policy Committee December 4, 2009 Amended/Revised April 22, 2010 Prepared by: Bucher..., Willis, and Ratliff Corporation 1828 East Southeast Loop 323, Suite 202 Tyler, Texas 75701 903.581.7844 This Document Serves as an Update to the Tyler Area Metropolitan Transportation Plan 2030. Portions of that Document were Unchanged and Appear...

  2. TransBorder 2035 Metropolitan Transportation Plan

    E-Print Network [OSTI]

    El Paso Metropolitan Planning Organization

    2007-11-16T23:59:59.000Z

    i TransBorder 2035 Metropolitan Transportation Plan November 16, 2007 El Paso Metropolitan Planning Organization www.elpasompo.org ii TransBorder 2035 Metropolitan Transportation Plan November 16, 2007... El Paso Metropolitan Planning Organization www.elpasompo.org iii TransBorder 2035 Metropolitan Transportation Plan November 16, 2007 El Paso Metropolitan Planning Organization www.elpasompo.org iv Trans...

  3. Baton Rouge Metropolitan Transportation Plan Update

    E-Print Network [OSTI]

    Capital Region Planning Commission

    (028) SUBMITTED TO: LOUISIANA DEPARTMENT OF TRANSPORTATION AND DEVELOPMENT SUBMITTED BY: IN ASSOCIATION WITH: & FINAL Metropolitan Transportation Plan Update Baton Rouge, LA... ............................189? X. APPENDIX .........................................................................................................................195? ? Metropolitan Transportation Plan Update...

  4. Metropolitan Transportation Plan 2009-2035

    E-Print Network [OSTI]

    South Central Planning and Development Commission

    2009-05-14T23:59:59.000Z

    ?? Metropolitan? Transportation?Plan? 2009?2035? ? This?document?is?the?long?range?transportation?plan?for?the?Houma?Thibodaux? Metropolitan?Planning?Organization.??It?represents?the?staged?implementation?of? the?transportation...?needs?in?the?Houma?Thibodaux?urbanized?area,?extending?from? 2009?to?2035.? ? Adopted?on?May?14,?2009? Prepared?by?the?South?Central?Planning?and?Development?Commission? ? Adopted My 14, 2009 [METROPOLITAN TRANSPORTATION PLAN] 2 Contents Chapters Page 1 Introduction 5 2 Existing...

  5. The Metropolitan Surface Water Management Act (Minnesota)

    Broader source: Energy.gov [DOE]

    The Metropolitan Surface Water Management Act aims to protect, preserve, and use natural, surface, and groundwater storage and retention systems; identify and plan for means to improve and protect...

  6. Metropolitan Accessibility and Transportation Sustainability:Sustainability

    E-Print Network [OSTI]

    Papalambros, Panos

    Metropolitan Accessibility and Transportation Sustainability:Sustainability: Comparative Reduce (fulfillment of)Promote Sustainability: Meet needs of (fulfillment of) needs present Institute SMART Sustainable Mobility and Accessibility Research andSMART Sustainable Mobility

  7. U.S. Metropolitan Spatial Structure and Employment Growth

    E-Print Network [OSTI]

    Huang, Xiaoyan

    2014-08-13T23:59:59.000Z

    This study explores the influence of US metropolitan spatial structure evolution on regional employment growth rate. The first part of this study investigates the evolution of US metropolitan spatial structures from 2000 to 2010. At the macro level...

  8. Learning sustainable metropolitan development for european students of planning

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Learning sustainable metropolitan development for european students of planning Serrano José, project assessment, sustainable developement, team work Introduction Metropolitan areas are experiencing ways which are more sustainable than others. In our planning training, we teach sustainable development

  9. METROPOLITAN TRANSPORTATION SUPPORT INITIATIVE (METSI) QUARTERLY REPORT

    E-Print Network [OSTI]

    Illinois at Chicago, University of

    METROPOLITAN TRANSPORTATION SUPPORT INITIATIVE (METSI) QUARTERLY REPORT for the quarter ending over 50%) of residents throughout the state of Illinois would support a 5 cent per gallon gas tax if the proceeds were to improve roads and transit. The other survey, 2002 Market Survey undertaken by RTA examined

  10. Metropolitan Transportation Plan Fiscal Year 2010 - 2035

    E-Print Network [OSTI]

    Corpus Christi Metropolitan Planning Organization

    2009-12-03T23:59:59.000Z

    Approved by the Transportation Policy Committee December 3, 2009 Disclaimer Statement: The preparation of this report has been financed in part through grant[s] from the Federal Highway Administration and Federal... Transit Administration, U.S. Department of Transportation, under the State Planning and Research Program, Section 505 [or Metropolitan Planning Program, Section 104(f)] of Title 23, U.S. Code. The contents of this report do not necessarily reflect...

  11. Connections 2035 The Waco Metropolitan Transportation Plan

    E-Print Network [OSTI]

    Waco Metropolitan Planning Organization

    2010-02-03T23:59:59.000Z

    Administration, Federal Transit Administration, and the Texas Department of Transportation. Preface The Waco Metropolitan Planning Organization has prepared this plan in compliance with the Safe, Accountable, Flexible and Efficient Transportation Equity Act...: A Legacy for Users (SAFETEA-LU). The preparation of this plan has been funded in part through grants by the Federal Highway Administration, the Federal Transit Administration and the Texas Department of Transportation. The contents...

  12. Metropolitan Transportation Plan 2005-2030

    E-Print Network [OSTI]

    Santa Fe Metropolitan Planning Organization

    1999-01-01T23:59:59.000Z

    The Santa Fe Metropolitan Transportation Plan 2005-2030 (MTP) replaces the Santa Fe MPO Long Range Transportation Plan 2000-2020 as a guide for developing a safer, more efficient and effective transportation system that serves the residents..., commuters and visitors to Santa Fe. The theme of ?providing interconnected options for more travel choices? reflects a strong public call for a safer and more functional interconnected network of roads, trails and transit routes that gives people a choice...

  13. Amarillo Metropolitan Transportation Plan 2010-2035

    E-Print Network [OSTI]

    Amarillo Metropolitan Planning Organization

    2009-10-15T23:59:59.000Z

    , natural resources, environmental protection, conservation, and historic preservation concerning the development of long- and short- range transportation plans. MPO maintains a website www.amarillompo.org that includes this Metropolitan Transportation... Commissioner City of Amarillo Alan M. Taylor City Manager City of Amarillo Howard Holland, P.E. District Engineer TxDOT Kenneth Petr, P.E. Dir. of Transportation Planning & Development TxDOT Judge Arthur Ware County Judge Potter County H.R. Kelly County...

  14. Metropolitan Road Traffic Simulation on FPGAs.

    SciTech Connect (OSTI)

    Tripp J. L. (Justin L.); Mortveit, H. S. (Henning S.); Hansson, A. A. (Anders A.); Gokhale, M. (Maya)

    2005-01-01T23:59:59.000Z

    This work demonstrates that road traffic simulation of entire metropolitan areas is possible with reconfigurable supercomputing that combines 64-bit microprocessors and FPGAs in a high bandwidth, low latency interconnect. Previously, traffic simulation on FPGAs was limited to very short road segments or required a very large number of FPGAs. Our data streaming approach overcomes scaling issues associated with direct implementations and still allows for high-level parallelism by dividing the data sets between hardware and software across the reconfigurable supercomputer. Using one FPGA on the Cray XD1 supercomputer, we are able to achieve a 34.4 x speed up over the AMD microprocessor. System integration issues must be optimized to exploit this speedup in the overall simulation.

  15. The structure of agriculture in metropolitan and nonmetropolitan America

    E-Print Network [OSTI]

    Scott, Michelle L

    2003-01-01T23:59:59.000Z

    variation of agristructure. Furthermore, total crop, grain, cotton, nursery/greenhouse, fruit/vegetable, and "other crop" sales revenues varied by metropolitan proximity, region, and farm system size. Ordinary least squares regression was employed...

  16. METROPOLITAN REPORT Economic Indicators for the New Orleans Area

    E-Print Network [OSTI]

    Kulp, Mark

    gained. Growth, while continuing, has slowed. · Construction, driven by recovery activity, is stronger or July 2007. Employment data at the metropolitan level under- went an enormous revision by the Louisiana

  17. american metropolitan areas: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    all-to-all traffic and regular ... Guan, Kyle C. 11 Impact of primary formaldehyde on air pollution in the Mexico City Metropolitan Area MIT - DSpace Summary: Formaldehyde (HCHO)...

  18. avoiding metropolitan areas: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    all-to-all traffic and regular ... Guan, Kyle C. 10 Impact of primary formaldehyde on air pollution in the Mexico City Metropolitan Area MIT - DSpace Summary: Formaldehyde (HCHO)...

  19. atlanta metropolitan area: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    all-to-all traffic and regular ... Guan, Kyle C. 10 Impact of primary formaldehyde on air pollution in the Mexico City Metropolitan Area MIT - DSpace Summary: Formaldehyde (HCHO)...

  20. Performance Measurement in Small Texas Metropolitan Planning Organizations

    E-Print Network [OSTI]

    Moore, Devin 1984-

    2012-10-16T23:59:59.000Z

    place including a rise in prominence of the Metropolitan Planning Organization (MPO). The public, state and local agencies, and other stakeholders are mutually served by the regional MPO to assure that transportation funding allocation and project...

  1. Metropolitan Edison Company SEF Loans (FirstEnergy Territory)

    Broader source: Energy.gov [DOE]

    FirstEnergy (formerly GPU) established the Metropolitan Edison Company Sustainable Energy Fund in 2000 with an initial contribution of $5.7 million. The fund later received an additional...

  2. The interests of landowners on the metropolitan fringe

    E-Print Network [OSTI]

    Molinsky, Jennifer H. (Jennifer Hrabchak)

    2005-01-01T23:59:59.000Z

    Numerous authors have noted that the patchy, sprawling pattern of development characterizing the metropolitan fringe results in part from the decisions of individual landowners regarding the use, subdivision, development, ...

  3. Efficient detection of contagious outbreaks in massive metropolitan encounter networks

    E-Print Network [OSTI]

    Sun, Lijun

    Physical contact remains difficult to trace in large metropolitan networks, though it is a key vehicle for the transmission of contagious outbreaks. Co-presence encounters during daily transit use provide us with a city-scale ...

  4. New Orleans Urbanized Area Metropolitan Transportation Plan FY 2032

    E-Print Network [OSTI]

    New Orleans Urbanized Area Regional Planning Commission

    2007-06-12T23:59:59.000Z

    which are more economical or which have less environmental eff ects while achieving similar transportation objectives. Burgeoning corridors such as the corridor between the Louis Armstrong International Airport and the Central Business District...2 0 23 F Y Metropolitan Transportation Plan New Orleans Urbanized AreaNew Regional Planning Commission Jefferson, Orleans Plaquemines, St. Bernard and St. Tammany Parishes, Louisiana June 12, 2007 Metropolitan Transportation Plan New Orleans...

  5. Hot Springs Metropolitan Planning Organization 2030 Long Range Transportation Plan

    E-Print Network [OSTI]

    Hot Springs Metropolitan Planning Organization

    2005-11-03T23:59:59.000Z

    Federal Highway Administration Federal Transit Administration 2030 Long Range Transportation Plan for the Hot Springs Area Metropolitan Planning Organization This LRTP has been funded with federal Metropolitan Planning (PL) funds through... the Federal Highway Administration, Section 5303 funds through the Federal Transit Administration, the State of Arkansas, and participating agency local match funds. HSA-MPO 100 Broadway Terrace Hot Springs, AR 71901 501-321-4804 HSA...

  6. Metropolitan area network support at Fermilab

    SciTech Connect (OSTI)

    DeMar, Phil; Andrews, Chuck; Bobyshev, Andrey; Crawford, Matt; Colon, Orlando; Fry, Steve; Grigaliunas, Vyto; Lamore, Donna; Petravick, Don; /Fermilab

    2007-09-01T23:59:59.000Z

    Advances in wide area network service offerings, coupled with comparable developments in local area network technology have enabled many research sites to keep their offsite network bandwidth ahead of demand. For most sites, the more difficult and costly aspect of increasing wide area network capacity is the local loop, which connects the facility LAN to the wide area service provider(s). Fermilab, in coordination with neighboring Argonne National Laboratory, has chosen to provide its own local loop access through leasing of dark fiber to nearby network exchange points, and procuring dense wave division multiplexing (DWDM) equipment to provide data channels across those fibers. Installing and managing such optical network infrastructure has broadened the Laboratory's network support responsibilities to include operating network equipment that is located off-site, and is technically much different than classic LAN network equipment. Effectively, the Laboratory has assumed the role of a local service provider. This paper will cover Fermilab's experiences with deploying and supporting a Metropolitan Area Network (MAN) infrastructure to satisfy its offsite networking needs. The benefits and drawbacks of providing and supporting such a service will be discussed.

  7. Sustainable metropolitan growth strategies : exploring the role of the built environment

    E-Print Network [OSTI]

    Diao, Mi, Ph. D. Massachusetts Institute of Technology

    2010-01-01T23:59:59.000Z

    The sustainability of metropolitan areas has been considered one of the most significant social challenges worldwide. Among the various policy options to achieve sustainable metropolitan growth, smart-growth strategies ...

  8. NF Energy Saving Corp | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere I Geothermal Pwer PlantMunhall, Pennsylvania: Energy Resources JumpNEF Advisors LLC JumpNF Energy Saving Corp

  9. Jonesboro Metropolitan Planning Organization 2030 Long Range Transportation Plan

    E-Print Network [OSTI]

    Jonesboro Metropolitan Planning Organization

    southern boundary. The airport is connected to the roadway system by Airport Road connecting Nettleton Avenue and US 49 (Johnson Avenue). According to the Federal Aviation Administration (FAA) information dated July 7, 2005, there are about 123...Jonesboro Metropolitan Planning Organization In cooperation with the Arkansas State Highway and Transportation Department United States Department of Transportation Federal Highway Administration Federal Transit Administration...

  10. Metropolitan Ethernet Network: A Move from LAN to MAN

    E-Print Network [OSTI]

    California at Davis, University of

    transformed from a CSMA/CD technology providing low throughput to a full duplex link increasing the throughput the transformation of Ethernet from the mainstream LAN technology to the possible adoption for metropolitan area networks (MENs). This paper will introduce the movement from basic Ethernet to the carrier grade Ethernet

  11. Energy Management Program atEnergy Management Program at Metropolitan Water District ofMetropolitan Water District of

    E-Print Network [OSTI]

    Keller, Arturo A.

    ;BackgroundBackground Climate change & global warming Greenhouse gas emissions Legislation ­ Governor's Executive Order S-3-05 ­ AB32: Reduction of GHG Emissions Climate change & global warming Greenhouse gas,385 GWh 2005 Metropolitan elect. usage = 1,940 GWh (0.7% of Calif.) ­ Enough electricity for 280,000 homes

  12. NF-?B Fans the Flames of Lung Carcinogenesis

    E-Print Network [OSTI]

    Jacks, Tyler E.

    This perspective on Deng et al. (beginning on p. 424 in this issue of the journal) examines the link between NF-?B and lung tumorigenesis. Experiments in genetically engineered mouse models of lung cancers are elucidating ...

  13. Universality of the Nf=2 Running Coupling

    E-Print Network [OSTI]

    K. Murano; S. Aoki; S. Takeda; Y. Taniguchi

    2009-03-06T23:59:59.000Z

    We investigate universality of the Nf=2 running coupling in the Sch\\"odinger functional scheme, by calculating the step scaling function in lattice QCD with the renorm alization group (RG) improved gauge action at both weak(u=0.9796) and strong(u=3.3340) couplings, where u=\\bar{g}^2_SF with \\bar{g}_SF being the running coupling in this scheme. In our main calculations, we use the tree-level value for O(a) improvement coefficients of boundary gauge fields. In addition we employ the 1-loop value for them in order to see how scaling behaviours are affected by them. In the continuum limit, the step scaling function obtained from the RG improved gauge actions agrees with the previous result obtained from the plaquette action within errors at both couplings, though errors of our result are larger. Combined fits using all data with the RG improved action as well as the plaquette action reduce errors in the continuum limit by 2% at the weak coupling and 22% at the strong coupling.

  14. Haploid reporter screens aimed at identification of NF-kappaB regulators

    E-Print Network [OSTI]

    Lee, Clarissa Ci

    2014-01-01T23:59:59.000Z

    Nuclear factor-kappaB (NF-KB) is a family of transcription factors that are essential for execution of both the innate and the adaptive immune response. NF-KB regulates hundreds of genes involved in critical processes such ...

  15. Efficient detection of contagious outbreaks in massive metropolitan encounter networks

    E-Print Network [OSTI]

    Sun, Lijun; Lee, Der-Horng; Cebrian, Manuel

    2014-01-01T23:59:59.000Z

    Physical contact remains difficult to trace in large metropolitan networks, though it is a key vehicle for the transmission of contagious outbreaks. Co-presence encounters during daily transit use provide us with a city-scale time-resolved physical contact network, consisting of 1 billion contacts among 3 million transit users. Here, we study the advantage that knowledge of such co-presence structures may provide for early detection of contagious outbreaks. We first examine the "friend sensor" scheme --- a simple, but universal strategy requiring only local information --- and demonstrate that it provides significant early detection of simulated outbreaks. Taking advantage of the full network structure, we then identify advanced "global sensor sets", obtaining substantial early warning times savings over the friends sensor scheme. Individuals with highest number of encounters are the most efficient sensors, with performance comparable to individuals with the highest travel frequency, exploratory behavior and ...

  16. Unequal development : decentralization and fiscal disparities in the Metropolitan Zone of the Valley of Mexico

    E-Print Network [OSTI]

    Raich, Uri

    2006-01-01T23:59:59.000Z

    This study is about the impact of decentralization in metropolitan areas. Studies of fiscal decentralization have largely centered on the formal tiers of government, without looking at the effects of this process on the ...

  17. Impact of primary formaldehyde on air pollution in the Mexico City Metropolitan Area

    E-Print Network [OSTI]

    Lei, Wenfang

    Formaldehyde (HCHO) is a radical source that plays an important role in urban atmospheric chemistry and ozone formation. The Mexico City Metropolitan Area (MCMA) is characterized by high anthropogenic emissions of HCHO ...

  18. Chemical evolution of volatile organic compounds in the outflow of the Mexico City Metropolitan area

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    and dispersion of a Mexico City pollution out- flow eventon air pollution in the Mexico City Metropolitan Area,pollution transport during the MILAGRO-2006 campaign: a case study of a major Mexico

  19. Planners and the Pork Barrel: Metropolitan Engagement in and Resistance to Congressional Transportation Earmarking

    E-Print Network [OSTI]

    Sciara, Gian-Claudia

    2009-01-01T23:59:59.000Z

    Tri-State Regional Planning Commission, which included metropolitan countiesCounty Department of Transportation Olivia Clark Executive Director of Governmental Affairs Tri-tri-state MPO in 1982, NYMTC has consisted of nine voting members, representing county

  20. Urban growth pattern and sustainable development: a comparative study of municipalities in the Seoul Metropolitan Region

    E-Print Network [OSTI]

    Paek, Seunggeun

    2006-10-30T23:59:59.000Z

    The main purpose of this study was to obtain a better understanding of the impact of urban growth and change on sustainability based on a comparative study of municipalities comprising Gyeonggi Province within the Seoul Metropolitan Region, Korea...

  1. Set of Comparable Carbon Footprints for Highway Travel in Metropolitan America

    SciTech Connect (OSTI)

    Southworth, Frank [ORNL; Sonnenberg, Anthon [Georgia Institute of Technology

    2011-01-01T23:59:59.000Z

    The authors describe the development of a set of carbon dioxide emissions estimates for highway travel by automobile, truck, bus and other public transit vehicle movements within the nation s 100 largest metropolitan areas, in calendar year 2005. Considerable variability is found to exist across metropolitan areas when these greenhouse gas emissions are measured on a per capita and a per gross metropolitan product (GMP) basis. Least square regression modeling shows a relationship between emissions per capita and per GMP with truck traffic share, transit share, employment density, population dispersion within the metro area, and GMP per capita. As a result many of the nation s largest metropolitan areas tend to have lower CO2 emissions per capita and per GMP than smaller and more recently developed metro areas.

  2. Economic impact of M.I.T. on Cambridge and Metropolitan Boston

    E-Print Network [OSTI]

    Finberg, Irving William

    1964-01-01T23:59:59.000Z

    This thesis investigated the economic impact of the Massachusetts Institute of Technology on its host city, Cambridge, and upon the Boston Metropolitan Area. The primary purpose was to develop sufficient information about ...

  3. Metropolitan governance and local land use planning in Boston, Denver, and Portland

    E-Print Network [OSTI]

    Rosan, Christina

    2007-01-01T23:59:59.000Z

    Metropolitan areas across the U.S. are characterized by sprawling development which uses larger amounts of open space than necessary, leads to the inefficient use of energy and water, increases social inequality, and causes ...

  4. The participation, spatial distribution, and consumption patterns of boaters residing in Metropolitan Toronto

    E-Print Network [OSTI]

    Weakley, John Robert James

    1971-01-01T23:59:59.000Z

    Board produced a conceptual plan for the redevelopment of the fifty miles of Lake Ontario shoreline within the Metropolitan Toronto Planning Area. Although the Plan provided for numerous marinas and boatramps, the Planning Board was hampered by a... to as the summer cottage is particularly well developed in Central Ontario (9). A large percentage of the boats licensed in Metropolitan Toronto are used in conjunction with these cottages (10). This porportionately high non-urban use of boats can be expected...

  5. Regional planning and operations architectures as means to foster transportation integration in the Mexico City Metropolitan Area

    E-Print Network [OSTI]

    Ortiz Mantilla, Bernardo Jose, 1977-

    2005-01-01T23:59:59.000Z

    The MCMA complexity in political, institutional, economical, and jurisdictional terms has resulted in limited coordination between MCMA authorities that in conjunction with the limited role of metropolitan transportation ...

  6. Porcine arterivirus activates the NF-{kappa}B pathway through I{kappa}B degradation

    SciTech Connect (OSTI)

    Lee, Sang-Myeong [Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri-Columbia, MO 65211 (United States); Kleiboeker, Steven B. [Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri-Columbia, MO 65211 (United States) and Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri-Columbia, MO 65211 (United States)]. E-mail: KleiboekerS@Missouri.edu

    2005-11-10T23:59:59.000Z

    Nuclear factor-kappaB (NF-{kappa}B) is a critical regulator of innate and adaptive immune function as well as cell proliferation and survival. The present study demonstrated for the first time that a virus belonging to the Arteriviridae family activates NF-{kappa}B in MARC-145 cells and alveolar macrophages. In porcine reproductive and respiratory syndrome virus (PRRSV)-infected cells, NF-{kappa}B activation was characterized by translocation of NF-{kappa}B from the cytoplasm to the nucleus, increased DNA binding activity, and NF-{kappa}B-regulated gene expression. NF-{kappa}B activation was increased as PRRSV infection progressed and in a viral dose-dependent manner. UV-inactivation of PRRSV significantly reduced the level of NF-{kappa}B activation. Degradation of I{kappa}B protein was detected late in PRRSV infection, and overexpression of the dominant negative form of I{kappa}B{alpha} (I{kappa}B{alpha}DN) significantly suppressed NF-{kappa}B activation induced by PRRSV. However, I{kappa}B{alpha}DN did not affect viral replication and viral cytopathic effect. PRRSV infection induced oxidative stress in cells by generating reactive oxygen species (ROS), and antioxidants inhibited NF-{kappa}B DNA binding activity in PRRSV-infected cells, suggesting ROS as a mechanism by which NF-{kappa}B was activated by PRRSV infection. Moreover, NF-{kappa}B-dependent expression of matrix metalloproteinase (MMP)-2 and MMP-9 was observed in PRRSV-infected cells, an observation which implies that NF-{kappa}B activation is a biologically significant aspect of PRRSV pathogenesis. The results presented here provide a basis for understanding molecular pathways of pathology and immune evasion associated with disease caused by PRRSV.

  7. Smoothing single-crystalline SiC surfaces by reactive ion etching using pure NF{sub 3} and NF{sub 3}/Ar mixture gas plasmas

    SciTech Connect (OSTI)

    Tasaka, Akimasa, E-mail: aki-tasaka-load@yahoo.co.jp [Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321, Japan and Department of Applied Chemistry, Graduate School of Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321 (Japan); Kotaka, Yuki [Department of Applied Chemistry, Graduate School of Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321 (Japan); Oda, Atsushi; Saito, Morihiro [Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321 (Japan); Tojo, Tetsuro [Toyo Tanso Co, Ltd., 5-7-2 Takeshima, Nishi yodogawa-ku, Osaka 555-0011 (Japan); Inaba, Minoru [Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321, Japan and Department of Applied Chemistry, Graduate School of Science and Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321 (Japan)

    2014-09-01T23:59:59.000Z

    In pure NF{sub 3} plasma, the etching rates of four kinds of single-crystalline SiC wafer etched at NF{sub 3} pressure of 2?Pa were the highest and it decreased with an increase in NF{sub 3} pressure. On the other hand, they increased with an increase in radio frequency (RF) power and were the highest at RF power of 200?W. A smooth surface was obtained on the single-crystalline 4H-SiC after reactive ion etching at NF{sub 3}/Ar gas pressure of 2?Pa and addition of Ar to NF{sub 3} plasma increased the smoothness of SiC surface. Scanning electron microscopy observation revealed that the number of pillars decreased with an increase in the Ar-concentration in the NF{sub 3}/Ar mixture gas. The roughness factor (R{sub a}) values were decreased from 51.5?nm to 25.5?nm for the As-cut SiC, from 0.25?nm to 0.20?nm for the Epi-SiC, from 5.0?nm to 0.7?nm for the Si-face mirror-polished SiC, and from 0.20?nm to 0.16?nm for the C-face mirror-polished SiC by adding 60% Ar to the NF{sub 3} gas. Both the R{sub a} values of the Epi- and the C-face mirror-polished wafer surfaces etched using the NF{sub 3}/Ar (40:60) plasma were similar to that treated with mirror polishing, so-called the Catalyst-Referred Etching (CARE) method, with which the lowest roughness of surface was obtained among the chemical mirror polishing methods. Etching duration for smoothing the single-crystalline SiC surface using its treatment was one third of that with the CARE method.

  8. 1 Managed by UT-Battelle for the U.S. Department of Energy NF Splash Mitigation 12 July 2011

    E-Print Network [OSTI]

    McDonald, Kirk

    1 Managed by UT-Battelle for the U.S. Department of Energy NF Splash Mitigation 12 July 2011 by UT-Battelle for the U.S. Department of Energy NF Splash Mitigation 12 July 2011 Splash Mitigation for comparison & final determination #12;3 Managed by UT-Battelle for the U.S. Department of Energy NF Splash

  9. DraftApril 7, 2009 Features of Climate-Smart Metropolitan Economies

    E-Print Network [OSTI]

    Draft­April 7, 2009 Chapter 8 Features of Climate-Smart Metropolitan Economies Marilyn A. Brown-carbon climate-smart leadership that is required to meet the nation's targets and timetables necessary to avoid emissions of carbon dioxide.) Residential and commercial buildings account for 39 percent of the carbon

  10. Computer Lab Software Installation Policy for the Metropolitan Instructional Support Laboratory

    E-Print Network [OSTI]

    Computer Lab Software Installation Policy for the Metropolitan Instructional Support Laboratory Laboratory (MISL) provides computer lab space for faculty, staff and student use as individuals or in classes on lab computers. This policy applies to both stationary and portable lab computers. Policy: Scenario 1

  11. ERASMUS 2011-2012. . Manchester Metropolitan University UK MANCHES 04 3 18

    E-Print Network [OSTI]

    Kouroupetroglou, Georgios

    ERASMUS 2011-2012. . . / . Manchester Metropolitan University UK MANCHES 04 3 18 PORTO 02 2 20 . University of Presov SK PRESOV 01 2 8 . Hacettepe University TR ANKARA 03 2 10 . University of Eastern Finland SF KUOPIO 12 4 18 Universitat fur Bodenkulrur Wien (BOKU) A WIEN 03 3 18

  12. ERASMUS 2011-2012. . Manchester Metropolitan University UK MANCHES 04 3 18

    E-Print Network [OSTI]

    Kouroupetroglou, Georgios

    ERASMUS 2011-2012. 1 . Manchester Metropolitan University UK MANCHES 04 3 18 PORTO 02 2 20 . University of Presov SK PRESOV 01 2 8 . Hacettepe University TR ANKARA 03 2 10 . University of Eastern Finland SF KUOPIO 12 4 18 Universitat fur Bodenkulrur Wien (BOKU) A WIEN 03 3 18

  13. BNY Mellon -Leading the way across the globe Manchester Metropolitan University

    E-Print Network [OSTI]

    BNY Mellon - Leading the way across the globe Manchester Metropolitan University 2012 #12;Page 2 business Established The Bank of New York Securities Co. Japan, Ltd. Established BNY Luxembourg Acquired) Luxembourg A radical increase in product breadth and global reach Early adopters of mainframe technology 1900

  14. Conservation justice in metropolitan Cape Town: A study at the Macassar Dunes Conservation Area

    E-Print Network [OSTI]

    Silander Jr., John A.

    Stakeholder analysis a b s t r a c t Conservation justice, a concept analogous to environmental justiceConservation justice in metropolitan Cape Town: A study at the Macassar Dunes Conservation Area J xxxx Keywords: Conservation justice Community-based conservation South Africa Urban conservation

  15. The Transportation Energy and Carbon Footprints of the 100 Largest U.S. Metropolitan Areas

    SciTech Connect (OSTI)

    Southworth, Frank [ORNL; Sonnenberg, Anthon [Georgia Institute of Technology; Brown, Marilyn A [ORNL

    2008-01-01T23:59:59.000Z

    We present estimates of the automobile and truck travel based energy and carbon footprints of the largest 100 U.S. metropolitan areas. The footprints are based on the estimated vehicle miles traveled and the transportation fuels consumed. Results are presented on an annual basis and represent end use emissions only. Total carbon emissions, emissions per capita, and emissions per dollar of gross metropolitan product are reported. Two years of annual data were examined, 2000 and 2005, with most of the in-depth analysis focused on the 2005 results. In section 2 we provide background data on the national picture and derive some carbon and energy consumption figures for the nation as a whole. In section 3 of the paper we examine the metropolitan area-wide results based on the sums and averages across all 100 metro areas, and compare these with the national totals and averages. In section 4 we present metropolitan area specific footprints and examine the considerable variation that is found to exist across individual metro areas. In doing so we pay particular attention to the effects that urban form might have on these differences. Finally, section 5 provides a summary of major findings, and a list of caveats that need to be borne in mind when using the results due to known limitations in the data sources used.

  16. IKK{epsilon} modulates RSV-induced NF-{kappa}B-dependent gene transcription

    SciTech Connect (OSTI)

    Bao Xiaoyong; Indukuri, Hemalatha; Liu Tianshuang; Liao Suiling [Department of Pediatrics, University of Texas Medical Branch, Galveston, TX (United States); Tian, Bing; Brasier, Allan R. [Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX (United States); Garofalo, Roberto P. [Department of Pediatrics, University of Texas Medical Branch, Galveston, TX (United States); Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX (United States); Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX (United States); Casola, Antonella, E-mail: ancasola@utmb.ed [Department of Pediatrics, University of Texas Medical Branch, Galveston, TX (United States); Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX (United States); Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX (United States)

    2010-12-20T23:59:59.000Z

    Respiratory syncytial virus (RSV), a negative-strand RNA virus, is the most common cause of epidemic respiratory disease in infants and young children. RSV infection of airway epithelial cells induces the expression of immune/inflammatory genes through the activation of a subset of transcription factors, including Nuclear Factor-{kappa}B (NF-{kappa}B). In this study we have investigated the role of the non canonical I{kappa}B kinase (IKK){epsilon} in modulating RSV-induced NF-{kappa}B activation. Our results show that inhibition of IKK{epsilon} activation results in significant impairment of viral-induced NF-{kappa}B-dependent gene expression, through a reduction in NF-{kappa}B transcriptional activity, without changes in nuclear translocation or DNA-binding activity. Absence of IKK{epsilon} results in a significant decrease of RSV-induced NF-{kappa}B phosphorylation on serine 536, a post-translational modification important for RSV-induced NF-{kappa}B-dependent gene expression, known to regulate NF-{kappa}B transcriptional activity without affecting nuclear translocation. This study identifies a novel mechanism by which IKK{epsilon} regulates viral-induced cellular signaling.

  17. Homeostatic control of IkappaB metabolism determines NF- kappaB responsiveness

    E-Print Network [OSTI]

    O'Dea, Ellen Louise

    2010-01-01T23:59:59.000Z

    19-26. O'Dea, E. and Hoffmann, A. 2009. NF-kappaB signaling.J.D. , Levchenko, A. , and Hoffmann, A. 2007. A homeostaticS.L. , Cheng, C. , and Hoffmann, A. 2007. A temporal code

  18. Response and Resistance to NF-?B Inhibitors in Mouse Models of Lung Adenocarcinoma

    E-Print Network [OSTI]

    Xue, Wen

    Lung adenocarcinoma is a leading cause of cancer death worldwide. We recently showed that genetic inhibition of the NF-?B pathway affects both the initiation and the maintenance of lung cancer, identifying this pathway as ...

  19. Requirement for NF-?B signalling in a mouse model of lung adenocarcinoma

    E-Print Network [OSTI]

    Meylan, Etienne

    NF-?B transcription factors function as crucial regulators of inflammatory and immune responses as well as of cell survival. They have also been implicated in cellular transformation and tumorigenesis. However, despite ...

  20. Modeling urban growth and land use/land cover change in the Houston Metropolitan Area from 2002 - 2030

    E-Print Network [OSTI]

    Oguz, Hakan

    2005-08-29T23:59:59.000Z

    spatially explicit cellular automata model, to simulate future (2002-2030) urban growth in the Houston metropolitan area, one of the fastest growing metropolises in the United States during the past decades. The model is calibrated with historical data...

  1. The case for pension plan and university endowment equity investment in brownfields in the urban core of major metropolitan areas

    E-Print Network [OSTI]

    Larsen, Tamara C. (Tamara Candace), 1977-

    2003-01-01T23:59:59.000Z

    The purpose of this thesis is to present a case for institutional equity investment in brownfields in the urban core of major metropolitan areas. Pension plans and university endowments are the primary institutional investors ...

  2. The effectiveness of jobs-housing balance as a strategy for reducing traffic congestion: a study of metropolitan Bangkok 

    E-Print Network [OSTI]

    Lobyaem, Sonchai

    2006-10-30T23:59:59.000Z

    Bangkok is widely known for its severe traffic congestion. The Thai government advocates the concept of jobs and housing balance (JHB) as a strategy for reducing traffic congestion in Metropolitan Bangkok. The basic idea ...

  3. The effectiveness of jobs-housing balance as a strategy for reducing traffic congestion: a study of metropolitan Bangkok

    E-Print Network [OSTI]

    Lobyaem, Sonchai

    2006-10-30T23:59:59.000Z

    Bangkok is widely known for its severe traffic congestion. The Thai government advocates the concept of jobs and housing balance (JHB) as a strategy for reducing traffic congestion in Metropolitan Bangkok. The basic idea is to decentralize the jobs...

  4. In situ measurements of speciated atmospheric mercury and the identification of source regions in the Mexico City Metropolitan Area

    E-Print Network [OSTI]

    Rutter, A. P.

    In order to expand the currently limited understanding of atmospheric mercury source-receptor relationships in the Mexico City Metropolitan Area, real time measurements of atmospheric mercury were made at a downtown urban ...

  5. A test of first order scaling in Nf=2 QCD

    E-Print Network [OSTI]

    G. Cossu; M. D'Elia; A. Di Giacomo; C. Pica

    2007-09-30T23:59:59.000Z

    We complete our analysis of Nf=2 QCD based on the lattice staggered fermion formulation. Using a series of Monte Carlo simulations at fixed (amq*Ls^yh) one is able to test the universality class with given critical exponent yh. This strategy has been used to test the O(4) universality class and it has been presented at the previous Lattice conferences. No agreement was found with simulations in the mass range amq=[0.01335,0.15] using lattices with Ls=16 up to 32 and Lt=4. With the same strategy, we now investigate the possibility of a first order transition using a new set of Monte Carlo data corresponding to yh=3 in the same mass and volume range as the one used for O(4). A substantial agreement is observed both in the specific heat scaling and in the scaling of the chiral condensate, while the chiral susceptibilities still presents visible deviation from scaling in the mass range explored.

  6. Sci. Aging Knowl. Environ., Vol. 2004, Issue 34, pp. nf78, 25 August 2004 [DOI: 10.1126/sageke.2004.34.nf78

    E-Print Network [OSTI]

    Seroude, Laurent

    : They scrubbed fly eggs with alcohol, fed the animals irradiated food, and kept them in sterile containers: http://sageke.sciencemag.org/cgi/content/full/2004/34/nf78 Nasty germs in fast-food burgers can kill direction--from fare that included antibiotics to "dirty" food--extended fly life on day 2 but not on day 4

  7. NF-?B1 Inhibits TLR-Induced IFN-? Production in Macrophages Through TPL-2-dependent ERK Activation

    E-Print Network [OSTI]

    Yang, Huei-Ting

    Although NF-?B1 p50/p105 has critical roles in immunity, the mechanism by which NF-?B1 regulates inflammatory responses is unclear. In this study, we analyzed the gene expression profile of LPS-stimulated Nfkb1?/? macrophages ...

  8. XIAP and cIAP1 amplifications induce Beclin 1-dependent autophagy through NF?B activation

    E-Print Network [OSTI]

    Lin, Fang; Ghislat, Ghita; Luo, Shouqing; Renna, Maurizio; Siddiqi, Farah; Rubinsztein, David C.

    2015-02-10T23:59:59.000Z

    ). In both steady state and stimulated conditions with TGF? that activates NF?B through TAK1 (33), nei- ther the overexpression of XIAP nor its knockdown affected the transcriptional activation of the NF?B promoter (Fig. 3B, top). The effect of TGF?...

  9. Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells

    SciTech Connect (OSTI)

    Jian Li

    2012-11-07T23:59:59.000Z

    A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

  10. Instruction sheet for the consolidation of the standard NF EN 693 dated September 2001 and its amendment A1 Machine tools : Safety : Hydraulic presses

    E-Print Network [OSTI]

    Association Française de Normalisation. Paris

    2009-01-01T23:59:59.000Z

    Instruction sheet for the consolidation of the standard NF EN 693 dated September 2001 and its amendment A1

  11. 1 Managed by UT-Battelle for the U.S. Department of Energy NF-IDS Videoconference 2 Jun 2009

    E-Print Network [OSTI]

    McDonald, Kirk

    1 Managed by UT-Battelle for the U.S. Department of Energy NF-IDS Videoconference 2 Jun 2009 by UT-Battelle for the U.S. Department of Energy NF-IDS Videoconference 2 Jun 2009 Purpose · Compare · Compilation of magnet geometry data #12;3 Managed by UT-Battelle for the U.S. Department of Energy NF

  12. Introduction The NF-B/Rel family of transcription factors is composed of

    E-Print Network [OSTI]

    Arnold, Jonathan

    gene expression exhibited a requirement for the host IKK complex. A detailed kinetic analysis of NF- B expression of anti-apoptotic genes and prevent death of infected cells in order to allow replication in a loss of the anti-apoptotic phenotype and a decrease in pro-survival gene expression (Molestina et al

  13. Single-cell NF-kB dynamics reveal digital activation and analogue information processing

    E-Print Network [OSTI]

    Quake, Stephen R.

    LETTERS Single-cell NF-kB dynamics reveal digital activation and analogue information processing and is a digital process at the single-cell level with fewer cells responding at lower doses. Cells also encode that reproduces both the digital and analogue dynamics as well as most gene expression profiles at all measured

  14. Microstructural Evolution in Two Variants of NF709 at 1023 and 1073 K

    E-Print Network [OSTI]

    Cambridge, University of

    and that could invalidate the extrapolations of short-term creep test data, and to identify any precipitates.K.D.H. BHADESHIA The microstructural state of two grades of the creep-resistant austenitic stainless steels NF709 regarded as one of the best austenitic steels for elevated temperature applications because of its creep

  15. Coal dust contiguity-induced changes in the concentration of TNF- and NF- B p65 on the ocular surface

    SciTech Connect (OSTI)

    Sun, Z.Y.; Hong, J.; Liu, Z.Y.; Jin, X.D.; Gu, C.H. [China Medical University, Shenyang (China)

    2009-07-01T23:59:59.000Z

    To observe the influence of coal dust on ocular surface of coal miners and rabbits with coal dust contiguity on expression TNF- and NF- Bp65 and dry eye occurrence. Expression TNF- and NF- Bp65 in ocular surface were determined. Results showed tear production, BUT and lysozyme decreased for coal miners and rabbits with coal dust contiguity. Coal dust exposure was linked to development of xerophthalmia, and induced a higher expression of NF- B p65 and TNF- perhaps as a mechanism to resist coal dust ocular surface injury.

  16. Omentin inhibits TNF-{alpha}-induced expression of adhesion molecules in endothelial cells via ERK/NF-{kappa}B pathway

    SciTech Connect (OSTI)

    Zhong, Xia, E-mail: zhongxia1977@126.com [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)] [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China); Li, Xiaonan; Liu, Fuli; Tan, Hui [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)] [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China); Shang, Deya, E-mail: wenhuashenghuo1@163.com [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)] [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)

    2012-08-24T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Omentin inhibited TNF-{alpha}-induced adhesion of THP-1 cells to HUVECs. Black-Right-Pointing-Pointer Omentin reduces expression of ICAM-1 and VCAM-1 induced by TNF-{alpha} in HUVECs. Black-Right-Pointing-Pointer Omentin inhibits TNF-{alpha}-induced ERK and NF-{kappa}B activation in HUVECs. Black-Right-Pointing-Pointer Omentin supreeses TNF-{alpha}-induced expression of ICAM-1 and VCAM-1 via ERK/NF-{kappa}B pathway. -- Abstract: In the present study, we investigated whether omentin affected the expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in tumor necrosis factor-{alpha} (TNF-{alpha}) induced human umbilical vein endothelial cells (HUVECs). Our data showed that omentin decreased TNF-{alpha}-induced expression of ICAM-1 and VCAM-1 in HUVECs. In addition, omentin inhibited TNF-{alpha}-induced adhesion of THP-1 cells to HUVECs. Further, we found that omentin inhibited TNF-{alpha}-activated signal pathway of nuclear factor-{kappa}B (NF-{kappa}B) by preventing NF-{kappa}B inhibitory protein (I{kappa}B{alpha}) degradation and NF-{kappa}B/DNA binding activity. Omentin pretreatment significantly inhibited TNF-{alpha}-induced ERK activity and ERK phosphorylation in HUVECs. Pretreatment with PD98059 suppressed TNF-{alpha}-induced NF-{kappa}B activity. Omentin, NF-kB inhibitor (BAY11-7082) and ERK inhibitor (PD98059) reduced the up-regulation of ICAM-1 and VCAM-1 induced by TNF-{alpha}. These results suggest that omentin may inhibit TNF-{alpha}-induced expression of adhesion molecules in endothelial cells via blocking ERK/NF-{kappa}B pathway.

  17. $Re(A_0)$, $Re(A_2)$ and RG evolution for $N_f=3$

    E-Print Network [OSTI]

    Choi, K; Choi, Keunsu; Lee, Weonjong

    2005-01-01T23:59:59.000Z

    We present results of $Re (A_0)$ and $Re (A_2)$ calculated using HYP staggered fermions on the lattice of $16^3 \\times 64$ at $\\beta=6.0$. These results are obtained using leading order chiral perturbation in quenched QCD. Buras's original RG evolution matrix develops a removable singularity for $N_f=3$. This subtlety is resolved by finding a finite solution to RG equation and the results are presented.

  18. Agreement Execution Process Study: CRADAs and NF-WFO Agreements and the Speed of Business

    SciTech Connect (OSTI)

    Harrer, Bruce J.; Cejka, Cheryl L.; Macklin, Richard; Miksovic, Ann

    2011-02-01T23:59:59.000Z

    This report summarizes the findings of a study on the execution of Cooperative Research and Development Agreements (CRADAs) and Non-Federal Work for Others (NF-WFO) agreements across the U.S. Department of Energy (DOE) laboratory complex. The study provides quantitiative estimates of times required to negotiate and execute these agreements across the DOE complex. It identifies factors impacting on cycle times and describes best practicies used at various laboratories and site offices that reduce cycle times.

  19. Using a Regional Chemical Transport Model for the Analysis of Gaseous and Particulate Air Pollutants in the Mexico City Metropolitan Area

    E-Print Network [OSTI]

    Ali, Sajjad Ghulam

    2012-02-14T23:59:59.000Z

    Air quality in the Mexico City Metropolitan Area (MCMA) is the subject of many studies due to concerns from high emissions and their adverse effects on public health and the environment. In this study, a high resolution simulation is performed...

  20. The value trees contribute to residential property in the Austin metropolitan area: a factor in assessing the impact of oak wilt

    E-Print Network [OSTI]

    Martin, Clay Whitney

    1986-01-01T23:59:59.000Z

    THE VALUE TREES CONTRIBUTE TO RESIDENTIAL PROPERTY IN THE AUSTIN METROPOLITAN AREA: A FACTOR IN ASSESSING THE IMPACT OF OAK WILT A Thesis by CLAY WHITNEY MARTIN Submitted to the Graduate College of Texas A&M University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE December 1986 Major Subject: Forestry THE VALUE TREES CONTRIBUTE TO RESIDENTIAL PROPERTY IN THE AUSTIN METROPOLITAN AREA: A FACTOR IN ASSESSING THE IMPACT OF OAK WILT A Thesis by CLAY WHITNEY MARTIN...

  1. NF-{kappa}B suppresses HIF-1{alpha} response by competing for P300 binding

    SciTech Connect (OSTI)

    Mendonca, Daniela B.S., E-mail: daniela_mendonca@dentistry.unc.edu [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil); Bone Biology and Implant Therapy Laboratory, Department of Prosthodontics, University of North Carolina at Chapel Hill, 330 Brauer Hall, CB 7450, Chapel Hill, NC 27599 (United States); Mendonca, Gustavo [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil) [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil); Bone Biology and Implant Therapy Laboratory, Department of Prosthodontics, University of North Carolina at Chapel Hill, 330 Brauer Hall, CB 7450, Chapel Hill, NC 27599 (United States); Aragao, Francisco J.L. [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil) [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil); Embrapa Recursos Geneticos e Biotecnologia, Laboratorio de Introducao e Expressao de Genes, PqEB W5 Norte, 70770-900 Brasilia, DF (Brazil); Cooper, Lyndon F., E-mail: lyndon_cooper@dentistry.unc.edu [Bone Biology and Implant Therapy Laboratory, Department of Prosthodontics, University of North Carolina at Chapel Hill, 330 Brauer Hall, CB 7450, Chapel Hill, NC 27599 (United States)

    2011-01-28T23:59:59.000Z

    Research highlights: {yields} p65 completely blocked HIF-1{alpha} activity at the HRE on different cell lines. {yields} p65 caused minor changes in HIF-1{alpha} and HIF-1{alpha} target genes mRNA expression. {yields} p65 reduced transcription of VEGF promoter. {yields} p65 competes with HIF-1{alpha} for p300. -- Abstract: Hypoxia has emerged as a key determinant of osteogenesis. HIF-1{alpha} is the transcription factor mediating hypoxia responses that include induction of VEGF and related bone induction. Inflammatory signals antagonize bone repair via the NF-{kappa}B pathway. The present investigation explored the functional relationship of hypoxia (HIF-1{alpha} function) and inflammatory signaling (NF-{kappa}B) in stem like and osteoprogenitor cell lines. The potential interaction between HIF-1{alpha} and NF-{kappa}B signaling was explored by co-transfection studies in hFOB with p65, HIF-1{alpha} and 9x-HRE-luc or HIF-1{alpha} target genes reporter plasmids. Nuclear cross-talk was directly tested using the mammalian Gal4/VP16 two-hybrid, and confirmed by co-immunoprecipitation/western blotting assays. The results show that inflammatory stimulation (TNF-{alpha} treatment) causes a marked inhibition of HIF-1{alpha} function at the HRE in all cell lines studied. Also, co-transfection with p65 expression vector leads to reduced hVEGFp transcription after DFO-induced hypoxia. However, TNF-{alpha} treatment had little effect on HIF-1{alpha} mRNA levels. The functional interaction of Gal4-HIF-1{alpha} and VP16-p300 fusion proteins is effectively blocked by expression of p65 in a dose dependent manner. It was concluded that NF-{kappa}B-mediated inflammatory signaling is able to block HIF-1{alpha} transactivation at HRE-encoding genes by direct competition for p300 binding at the promoter. Inflammation may influence the stem cell niche and tissue regeneration by influencing cellular responses to hypoxia.

  2. IDS-NF Impact of Neutrino Cross Section Impact of Neutrino Cross Section

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh School footballHydrogen andHypernuclei in Hall CInbydoeCELLIDRMSIDS-NF

  3. FY13 Summary Report on the Augmentation of the Spent Fuel Composition Dataset for Nuclear Forensics: SFCOMPO/NF

    SciTech Connect (OSTI)

    Brady Raap, Michaele C.; Lyons, Jennifer A.; Collins, Brian A.; Livingston, James V.

    2014-03-31T23:59:59.000Z

    This report documents the FY13 efforts to enhance a dataset of spent nuclear fuel isotopic composition data for use in developing intrinsic signatures for nuclear forensics. A review and collection of data from the open literature was performed in FY10. In FY11, the Spent Fuel COMPOsition (SFCOMPO) excel-based dataset for nuclear forensics (NF), SFCOMPO/NF was established and measured data for graphite production reactors, Boiling Water Reactors (BWRs) and Pressurized Water Reactors (PWRs) were added to the dataset and expanded to include a consistent set of data simulated by calculations. A test was performed to determine whether the SFCOMPO/NF dataset will be useful for the analysis and identification of reactor types from isotopic ratios observed in interdicted samples.

  4. ABD56 causes osteoclast apoptosis by inhibiting the NF{kappa}B and ERK pathways

    SciTech Connect (OSTI)

    Idris, Aymen [Rheumatic Diseases Unit, Molecular Medicine Centre, University of Edinburgh, General Western Hospital, Edinburgh, EH4 2XU (United Kingdom); Mrak, Emanuela [Bone Metabolic Unit, Scientific Institute H San Raffaele, via Olgettina 60, 20132 Milano (Italy); Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, via Vanvitelli 32, 20129 Milano (Italy); Greig, Iain [Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD (United Kingdom); Guidobono, Francesca [Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, via Vanvitelli 32, 20129 Milano (Italy); Ralston, Stuart H. [Rheumatic Diseases Unit, Molecular Medicine Centre, University of Edinburgh, General Western Hospital, Edinburgh, EH4 2XU (United Kingdom); Hof, Rob van 't [Rheumatic Diseases Unit, Molecular Medicine Centre, University of Edinburgh, General Western Hospital, Edinburgh, EH4 2XU (United Kingdom)], E-mail: rvanthof@staffmail.ed.ac.uk

    2008-06-20T23:59:59.000Z

    We have previously shown that the biphenylcarboxylic acid butanediol ester (ABD56) inhibits osteoclast formation and activity in vitro and in vivo. However, the mechanism of action of this compound is unknown. ABD56 inhibited osteoclast formation and caused osteoclast apoptosis, but had no effects on osteoblasts or macrophages. As the NF{kappa}B and MAPK pathways are essential for osteoclast formation and survival, we studied the effects of ABD56 on these pathways. ABD56 caused phosphorylation of p38, JNK and nuclear translocation of c-jun in osteoclasts. ABD56-induced apoptosis was prevented by the caspase inhibitor zVAD-fmk but was not prevented by the p38- or JNK-inhibitors. ABD56 completely abolished RANKL-induced I{kappa}B and ERK1/2 phosphorylation. Increasing the amount of RANKL partially rescued ABD56-induced apoptosis, indicating that the apoptosis is most probably due to the inhibition of survival signals such as ERK and NF{kappa}B, rather than activation of the p38 or Jnk MAPK pathways.

  5. The influence of coyotes on an urban Canada goose population in the Chicago metropolitan area

    SciTech Connect (OSTI)

    Brown, Justin L.; /Ohio State U.

    2007-01-01T23:59:59.000Z

    Canada geese (Branta canadensis) have become common in many urban areas, often creating nuisance problems for human residents. The presence of urban geese has raised concerns about the spread of disease, increased erosion, excessive noise, eutrophication of waterways, and general nuisance problems. Goose populations have grown due to an increase in urbanization resulting in an abundance of high quality food (urban grass) and suitable nesting sites, as well as a decrease in some predators. I monitored nest predation in the Chicago suburbs during the 2004 and 2005 nesting seasons using 3 nest monitoring techniques to identify predators: video cameras, plasticine eggs, and sign from nest using a classification tree analysis. Of 58 nests monitored in 2004 and 286 in 2005, only raccoons (Procyon lotor) and coyotes (Canis latrans) were identified as nest predators. Raccoons were responsible for 22-25% of depredated nests, but were rarely capable of depredating nests that were actively defended by a goose. Coyotes were responsible for 75-78% of all Canada goose nest depredation and were documented killing one adult goose and feeding on several others. The coyote is a top-level predator that had increased in many metropolitan areas in recent years. To determine if coyotes were actively hunting geese or eggs during the nesting season, I analyzed coyote habitat selection between nesting and pre-nesting or post-nesting seasons. Coyote home ranges (95% Minimum Convex Polygon) were calculated for 19 coyotes to examine third order habitat selection related to goose nest abundance. A 100 m buffer (buffer habitat) was created and centered on each waterway edge and contained 90% of all nests. Coyotes showed selection for habitats during all seasons. Buffer habitat was the top ranked habitat in both pre-nesting and nesting seasons, but dropped to third ranked in post-nesting season. Habitat selection across seasons was compared using a repeated measures MANOVA. Habitat selection between pre-nesting and nesting seasons (P=0.72) were similar, while between post-nesting and nesting seasons there was a nearly significant difference (P=0.07). The insignificant change in habitat use across seasons suggests that coyotes did not switch habitat use to take advantage of goose nests. Alternatively, the change in ranking of buffer habitat across seasons suggests that coyotes may have switched habitat use to take advantage of goose nests. The results are not clear as large individual variation between coyotes due to differences in habitat availability, and social status interfere with the results of the analysis. Even though I failed to find strong support for coyotes actively hunting goose nests, they nevertheless were the primary nest predator in the area and may influence Canada goose populations. To determine the potential influence of coyotes on the Canada goose population, I created a Canada goose matrix population model that included variables such as coyote predation on adults and nests as well as coyote influence on nest desertion. Using the base population model I calculated the Canada goose population to be increasing with {lambda} = 1.055. The removal of all coyote influence on the goose population would allow {lambda} to increase to 1.214. Nest predation was the most important factor related to coyotes: the removal of coyote nest predation from the model resulted in a population growth rate {lambda} = 1.157. Modeling results suggest coyotes are serving as a limiting factor for the Canada goose population within the Chicago metropolitan area.

  6. A comprehensive study of Superfund program benefits in the Denver and Tampa Bay metropolitan areas

    SciTech Connect (OSTI)

    Held, K.; Casper, B.; Siddhanti, S.K. [Booz Allen and Hamilton, Inc., McLean, VA (United States); Smith, E.R. [Environmental Protection Agency, Washington, DC (United States)

    1995-12-31T23:59:59.000Z

    The purpose of the study is to evaluate the benefits of the Superfund program in selected geographic areas. The study demonstrates how the cleanup of Superfund sites has improved the overall quality of life of those in the affected communities. The study presents findings on the benefits of Superfund cleanup activity in the Denver, Colorado and Tampa Bay, Florida metropolitan areas. Denver and Tampa Bay were chosen from several areas that the EPA evaluated and screened during the initial phase of the study. These locations were chosen because of a substantial presence of Superfund activities, making it possible to assess the efficacy of the program. Several features make this study unique in terms of its overall goal. The study examines a broad range of benefit categories related to human health, environmental, and socioeconomic effects of Superfund cleanup activities. The study is also designed to assess benefits due to completed, current, and future planned activity at Superfund sites. This assessment covers Federal remedial activities at National Priorities List (NPL) sites, as well as relevant Federal removal actions in the study areas. These benefits are investigated from an area-wide perspective, as opposed to site-by-site, to determine Superfund`s overall effect on the communities in each area. The study consists of two major phases: Phase 1: Screening and ranking 16 prospective geographic areas and selecting Denver and Tampa Bay as the most appropriate areas for in-depth analysis; and Phase 2: Developing methodologies for assessing benefits, collecting relevant data, and analyzing the benefits from Superfund cleanup activity.

  7. (Draft) Community air pollution and mortality: Analysis of 1980 data from US metropolitan areas

    SciTech Connect (OSTI)

    Lipfert, F.W.

    1992-11-01T23:59:59.000Z

    1980 data from up to 149 metropolitan areas were used to define cross-sectional associations between community air pollution and ``excess`` human mortality. The regression model proposed by Ozkaynak and Thurston (1987), which accounted for age, race, education, poverty, and population density, was evaluated and several new models were developed. The new models also accounted for migration, drinking water hardness, and smoking, and included a more detailed description of race. Cause-of-death categories analyzed include all causes, all ``non-external`` causes, major cardiovascular diseases, and chronic obstructive pulmonary diseases (COPD). Both annual mortality rates and their logarithms were analyzed. Air quality data were obtained from the EPA AIRS database (TSP, SO{sub 4}{sup =}, Mn, and ozone) and from the inhalable particulate network (PM{sub 15}, PM{sub 2.5} and SO{sub 4}{sup =}, for 63{sup 4} locations). The data on particulates were averaged across all monitoring stations available for each SMSA and the TSP data were restricted to the year 1980. The associations between mortality and air pollution were found to be dependent on the socioeconomic factors included in the models, the specific locations included in the data set, and the type of statistical model used. Statistically significant associations were found as follows: between TSP and mortality due to non-external causes with log-linear models, but not with a linear model betweenestimated 10-year average (1980--90) ozone levels and 1980 non-external and cardiovascular deaths; and between TSP and COPD mortality for both linear and log-linear models. When the sulfate contribution to TSP was subtracted, the relationship with COPD mortality was strengthened.

  8. (Draft) Community air pollution and mortality: Analysis of 1980 data from US metropolitan areas

    SciTech Connect (OSTI)

    Lipfert, F.W.

    1992-11-01T23:59:59.000Z

    1980 data from up to 149 metropolitan areas were used to define cross-sectional associations between community air pollution and excess'' human mortality. The regression model proposed by Ozkaynak and Thurston (1987), which accounted for age, race, education, poverty, and population density, was evaluated and several new models were developed. The new models also accounted for migration, drinking water hardness, and smoking, and included a more detailed description of race. Cause-of-death categories analyzed include all causes, all non-external'' causes, major cardiovascular diseases, and chronic obstructive pulmonary diseases (COPD). Both annual mortality rates and their logarithms were analyzed. Air quality data were obtained from the EPA AIRS database (TSP, SO[sub 4][sup =], Mn, and ozone) and from the inhalable particulate network (PM[sub 15], PM[sub 2.5] and SO[sub 4][sup =], for 63[sup 4] locations). The data on particulates were averaged across all monitoring stations available for each SMSA and the TSP data were restricted to the year 1980. The associations between mortality and air pollution were found to be dependent on the socioeconomic factors included in the models, the specific locations included in the data set, and the type of statistical model used. Statistically significant associations were found as follows: between TSP and mortality due to non-external causes with log-linear models, but not with a linear model betweenestimated 10-year average (1980--90) ozone levels and 1980 non-external and cardiovascular deaths; and between TSP and COPD mortality for both linear and log-linear models. When the sulfate contribution to TSP was subtracted, the relationship with COPD mortality was strengthened.

  9. Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-{kappa}B in hepatoma cells

    SciTech Connect (OSTI)

    Zhao, Yu [Department of Biochemistry, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071 (China)] [Department of Biochemistry, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071 (China); Wang, Wenhui [Department of Interventional Radiography, First Hospital of Lanzhou University, No.1 Donggang West Road, Lanzhou, Gansu Province 730000 (China)] [Department of Interventional Radiography, First Hospital of Lanzhou University, No.1 Donggang West Road, Lanzhou, Gansu Province 730000 (China); Wang, Qi [Department of Cancer Research, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China)] [Department of Cancer Research, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China); Zhang, Xiaodong, E-mail: zhangxd@nankai.edu.cn [Department of Cancer Research, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China)] [Department of Cancer Research, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China); Ye, Lihong, E-mail: yelihong@nankai.edu.cn [Department of Biochemistry, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071 (China)] [Department of Biochemistry, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071 (China)

    2012-02-24T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer 5-LOX is able to upregulate expression of NF-{kappa}B p65. Black-Right-Pointing-Pointer 5-LOX enhances nuclear translocation of NF-{kappa}B p65 via increasing p-I{kappa}B-{alpha} level. Black-Right-Pointing-Pointer 5-LOX stimulates transcriptional activity of NF-{kappa}B in hepatoma cells. Black-Right-Pointing-Pointer LTB4 activates transcriptional activity of NF-{kappa}B in hepatoma cells. -- Abstract: The issue that lipid metabolism enzyme and its metabolites regulate transcription factors in cancer cell is not fully understood. In this study, we first report that the lipid metabolism enzyme 5-Lipoxygenase (5-LOX) and its metabolite leukotriene B4 (LTB4) are capable of activating nuclear factor-{kappa}B (NF-{kappa}B) in hepatoma cells. We found that the treatment of MK886 (an inhibitor of 5-LOX) or knockdown of 5-LOX was able to downregulate the expression of NF-{kappa}B p65 at the mRNA level and decreased the phosphorylation level of inhibitor {kappa}B{alpha} (I{kappa}B{alpha}) in the cytoplasm of hepatoma HepG2 or H7402 cells, which resulted in the decrease of the level of nuclear NF-{kappa}B p65. These were confirmed by immunofluorescence staining in HepG2 cell. Moreover, the above treatments were able to decrease the transcriptional activity of NF-{kappa}B in the cells. The LTB4, one of metabolites of 5-LOX, is responsible for 5-LOX-activated NF-{kappa}B in a dose-dependent manner. Thus, we conclude that the lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-{kappa}B in hepatoma cells. Our finding provides new insight into the significance of lipid metabolism in activation of transcription factors in cancer.

  10. mm-Wave Op-Amps employing simple-Miller compensation, with OIP3/PDC ratios of 211 (10 dB NF) and 144 (6.0 dB NF) at 2 GHz

    E-Print Network [OSTI]

    Rodwell, Mark J. W.

    mm-Wave Op-Amps employing simple-Miller compensation, with OIP3/PDC ratios of 211 (10 dB NF/PDC ratio at fs = 2-3 GHz, compared to state-of-the-art. We address considerations important 1000 mW power dissipation PDC . This very high ratio of output-referred third-order-intercept power

  11. Cooling energy savings potential of light-colored roofs for residential and commercial buildings in 11 US metropolitan areas

    SciTech Connect (OSTI)

    Konopacki, S.; Akbari, H.; Pomerantz, M.; Gabersek, S.; Gartland, L.

    1997-05-01T23:59:59.000Z

    Light-colored roofs reflect more sunlight than dark roofs, thus they keep buildings cooler and reduce air-conditioning demand. Typical roofs in the United States are dark, which creates a potential for savings energy and money by changing to reflective roofs. In this report, the authors make quantitative estimates of the impact of roof color by simulating prototypical buildings with light- and dark-colored roofs and calculating savings by taking the differences in annual cooling and heating energy use, and peak electricity demand. Monetary savings are calculated using local utility rates. Savings are estimated for 11 U.S. Metropolitan Statistical Areas (MSAs) in a variety of climates.

  12. Modeling green fluorescent protein transcription, translation and modification as a method to obtain NF-kappaB activation profiles

    E-Print Network [OSTI]

    Laible, Allyson Marie

    2009-05-15T23:59:59.000Z

    that fluorescence increases up to 24 hours after an initial delay of approximately four hours. The fluorescence data was also used to develop a model describing significant events leading to NF-?B activation and GFP expression. In addition, a model describing...

  13. TCR and CD28 activate the transcription factor NF- B in T-cells viadistinct adaptor signaling complexes

    E-Print Network [OSTI]

    Thaker, Youg Raj; Schneider, Helga; Rudd, Christopher E.

    2014-10-23T23:59:59.000Z

    of NF-{kappa}B activation in T cells via association of the adapter proteins ADAP and CARMA1. Science 2007;316:754–8. [30] Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, et al. Phosphorylation of the CARMA1 linker...

  14. Enhancement of CD8+ T-cell memory by removal of a vaccinia virus NF-?B inhibitor

    E-Print Network [OSTI]

    Ren, Hongwei; Ferguson, Brian J.; de Motes, Carlos Maluquer; Sumner, Rebecca P.; Harman, Laura; Smith, Geoffrey L.

    2014-11-07T23:59:59.000Z

    induction of NF-kappaB activation via an ERK2 pathway in virus-infected human embryonic kidney cells. J Virol 2006;80(17):8676-85. 63. Harte MT, Haga IR, Maloney G, et al. The poxvirus protein A52R targets Toll-like receptor signaling complexes...

  15. Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-{kappa}B-mediated survival signaling

    SciTech Connect (OSTI)

    Leskinen, Markus J. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Heikkilae, Hanna M. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Speer, Mei Y. [Bioengineering Department, University of Washington, Seattle, WA 98195 (United States); Hakala, Jukka K. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Laine, Mika [Department of Medicine, Helsinki University Central Hospital and Minerva Institute for Medical Research, Helsinki (Finland); Kovanen, Petri T. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Lindstedt, Ken A. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland)]. E-mail: ken.lindstedt@wri.fi

    2006-05-01T23:59:59.000Z

    Chymase released from activated mast cells induces apoptosis of vascular smooth muscle cells (SMCs) in vitro by degrading the pericellular matrix component fibronectin, so causing disruption of focal adhesion complexes and Akt dephosphorylation, which are necessary for cell adhesion and survival. However, the molecular mechanisms of chymase-mediated apoptosis downstream of Akt have remained elusive. Here, we show by means of RT-PCR, Western blotting, EMSA, immunocytochemistry and confocal microscopy, that chymase induces SMC apoptosis by disrupting NF-{kappa}B-mediated survival signaling. Following chymase treatment, the translocation of active NF-{kappa}B/p65 to the nucleus was partly abolished and the amount of nuclear p65 was reduced. Pretreatment of SMCs with chymase also inhibited LPS- and IL-1{beta}-induced nuclear translocation of p65. The chymase-induced degradation of p65 was mediated by active caspases. Loss of NF-{kappa}B-mediated transactivation resulted in downregulation of bcl-2 mRNA and protein expression, leading to mitochondrial swelling and release of cytochrome c. The apoptotic process involved activation of both caspase 9 and caspase 8. The results reveal that, by disrupting the NF-{kappa}B-mediated survival-signaling pathway, activated chymase-secreting mast cells can mediate apoptosis of cultured arterial SMCs. Since activated mast cells colocalize with apoptotic SMCs in vulnerable areas of human atherosclerotic plaques, they may participate in the weakening and rupture of atherosclerotic plaques.

  16. Journal of Membrane Science 256 (2005) 134142 Characterization of novel acid-stable NF membranes before and after

    E-Print Network [OSTI]

    Freger, Viatcheslav "Slava"

    2005-01-01T23:59:59.000Z

    to hot 20% sulfuric acid solutions for various times. Swelling and morphological changes measured Nanofiltration (NF) membranes represent a class of mem- branes with capabilities to selectively separate low- sulfone, which support an ultra-thin selective layer a few tens to a few hundred of nanometers thick

  17. D-Dbar Mixing in the Standard Model and Beyond from Nf=2 Twisted Mass QCD

    E-Print Network [OSTI]

    N. Carrasco; M. Ciuchini; P. Dimopoulos; R. Frezzotti; V. Gimenez; V. Lubicz; G. C. Rossi; F. Sanfilippo; L. Silvestrini; S. Simula; C. Tarantino

    2014-06-13T23:59:59.000Z

    We present the first unquenched lattice QCD results for the bag parameters controlling the short distance contribution to D meson oscillations in the Standard Model and beyond. We have used the gauge configurations produced by the European Twisted Mass Collaboration with Nf = 2 dynamical quarks, at four lattice spacings and light meson masses in the range 280-500 MeV. Renormalization is carried out non-perturbatively with the RI-MOM method. The bag-parameter results have been used to constrain New Physics effects in D-Dbar mixing, to put a lower bound to the generic New Physics scale and to constrain off-diagonal squark mass terms for TeV-scale Supersymmetry.

  18. Kaon semileptonic vector form factor with $N_f=2+1+1$ Twisted Mass fermions

    E-Print Network [OSTI]

    Nuria Carrasco; Paolo Lami; Vittorio Lubicz; Eleonora Picca; Lorenzo Riggio; Silvano Simula; Cecilia Tarantino

    2014-10-27T23:59:59.000Z

    We investigate the vector form factor relevant for the $K_{\\ell 3}$ semileptonic decay using maximally twisted-mass fermions with 4 dynamical flavours ($N_f=2+1+1$). Our simulations feature pion masses ranging from $210$ MeV to approximately $450$ MeV and lattice spacing values as small as $0.06$fm. Our main result for the vector form factor at zero 4-momentum transfer is $f_+(0)=0.9683(65)$ where the uncertainty is both statistical and systematic. By combining our result with the experimental value of $f_+(0)|V_{us}|$ we obtain $|V_{us}|=0.2234(16)$, which satisfies the unitarity constraint of the Standard Model at the permille level.

  19. Ascorbic acid suppresses endotoxemia and NF-?B signaling cascade in alcoholic liver fibrosis in guinea pigs: A mechanistic approach

    SciTech Connect (OSTI)

    Abhilash, P.A.; Harikrishnan, R.; Indira, M., E-mail: indiramadambath@gmail.com

    2014-01-15T23:59:59.000Z

    Alcohol consumption increases the small intestinal bacterial overgrowth (SIBO) and intestinal permeability of endotoxin. The endotoxin mediated inflammatory signaling plays a major role in alcoholic liver fibrosis. We evaluated the effect of ascorbic acid (AA), silymarin and alcohol abstention on the alcohol induced endotoxemia and NF-?B activation cascade pathway in guinea pigs (Cavia porcellus). Guinea pigs were administered ethanol at a daily dose of 4 g/kg b.wt for 90 days. After 90 days, ethanol administration was stopped. The ethanol treated animals were divided into abstention, silymarin (250 mg/kg b.wt) and AA (250 mg/kg b.wt) supplemented groups and maintained for 30 days. The SIBO, intestinal permeability and endotoxin were significantly increased in the ethanol group. The mRNA expressions of intestinal proteins claudin, occludin and zona occludens-1 were significantly decreased in ethanol group. The mRNA levels of inflammatory receptors, activity of IKK? and the protein expressions of phospho-I?B?, NF-?B, TNF-?, TGF-?{sub 1} and IL-6 were also altered in ethanol group. The expressions of fibrosis markers ?-SMA, ?{sub 1} (I) collagen and sirius red staining in the liver revealed the induction of fibrosis. But the supplementation of AA could induce greater reduction of ethanol induced SIBO, intestinal barrier defects, NF-?B activation and liver fibrosis than silymarin. The possible mechanism may be the inhibitory effect of AA on SIBO, intestinal barrier defect and IKK?, which decreased the activation of NF-?B and synthesis of cytokines. This might have led to suppression of HSCs activation and liver fibrosis. - Highlights: • Alcohol increases intestinal bacterial overgrowth and permeability of endotoxin. • Endotoxin mediated inflammation plays a major role in alcoholic liver fibrosis. • Ascorbic acid reduces endotoxemia, NF-?B activation and proinflammatory cytokines. • AA's action is by inhibition of SIBO, IKK? and alteration of intestinal permeability. • This might have led to suppression of HSCs activation and liver fibrosis.

  20. Chemical evolution of volatile organic compounds in the outflow of the Mexico City Metropolitan area

    SciTech Connect (OSTI)

    Apel, Eric; Emmons, L.; Karl, Thomas G.; Flocke, Frank M.; Hills, A. J.; Madronich, Sasha; Lee-Taylor, J.; Fried, Alan; Weibring, P.; Walega, J.; Richter, Dirk; Tie, X.; Mauldin, L.; Campos, Teresa; Weinheimer, Andrew J.; Knapp, David; Sive, B.; Kleinman, Lawrence I.; Springston, S.; Zaveri, Rahul A.; Ortega, John V.; Voss, Paul B.; Blake, D. R.; Baker, Angela K.; Warneke, Carsten; Welsh-Bon, Daniel; de Gouw, Joost A.; Zheng, J.; Zhang, Renyi; Rudolph, Jochen; Junkermann, W.; Riemer, D.

    2010-01-01T23:59:59.000Z

    The volatile organic compound (VOC) distribution in the Mexico City Metropolitan Area (MCMA) and its evolution as it is uplifted and transported out of the MCMA basin was studied during the 2006 MILAGRO/MIRAGE-Mex field campaign. The results show that in the morning hours in the city center, the VOC distribution is dominated by non-methane hydrocarbons (NMHCs) but with a substantial contribution from oxygenated volatile organic compounds (OVOCs), predominantly from primary emissions. Alkanes account for a large part of the NMHC distribution in terms of mixing ratios. In terms of reactivity, NMHCs also dominate overall, especially in the morning hours. However, in the afternoon, as the boundary layer lifts and air is mixed and aged within the basin, the distribution changes as secondary products are formed. The WRF-Chem (Weather Research and Forecasting with Chemistry) model and MOZART (Model for Ozone and Related chemical Tracers) were able to reproduce the general features of the daytime cycle of the VOC OH reactivity distribution showing that NMHCs dominate the distribution except in the afternoon hours and that the VOC OH reactivity peaks in the early morning due to high morning emissions from the city into a shallow boundary layer. The WRF-Chem and MOZART models showed higher reactivity than the experimental data during the nighttime cycle, perhaps indicating problems with the modeled nighttime boundary layer height. In addition, a plume was studied in which air was advected out of the MCMA and intercepted downwind with the DOE G1 on March 18 and the NCAR C130 one day later on March 19. A number of identical species measured aboard each aircraft gave insight into the chemical evolution of the plume as it aged and was transported as far as 1000 km downwind. Ozone and many OVOCs were photochemically produced in the plume. The WRF-Chem and MOZART models were used to examine the spatial and temporal extent of the March 19 plume and to help interpret the OH reactivity in the downwind plume. The model results generally showed good agreement with experimental results for the total VOC OH reactivity downwind and gave insight into the distributions of VOC chemical classes downwind. A box model with detailed gas phase chemistry (NCAR Master Mechanism), initialized with concentrations observed at one of the ground sites in the MCMA, was used to examine the expected evolution of specific VOCs over a 1-2 day period. The models clearly supported the experimental evidence for NMHC oxidation leading to the formation of OVOCs downwind, which then become the primary fuel for ozone production far away from the MCMA.

  1. NF-kB activity-dependent P-selectin involved in ox-LDL-induced foam cell formation in U937 cell

    SciTech Connect (OSTI)

    Wang, Yi, E-mail: wangyi2004a@126.com [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China)] [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China); Wang, Xiang; Sun, Minghui; Zhang, Zhenyu; Cao, Heng; Chen, Xiaoqing [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China)] [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China)

    2011-08-05T23:59:59.000Z

    Highlights: {yields} Ox-LDL induced foam cell formation in the human U937 promonocytic cell line in a dose- and time-dependent manner. {yields} Ox-LDL induced expression of P-selectin through degradation of IkBa and augment of NF-kB activity and protein level during macrophage-derived foam cell formation. {yields} P-selectin and NF-kB may be identified as pivotal regulators of ox-LDL-induced foam cell formation. {yields} Therapy based on the inhibition of P-selectin and NF-kB may complement conventional treatments to prevent atherosclerosis. -- Abstract: Oxidized low-density lipoprotein (ox-LDL) plays a critical role in regulation of atherosclerosis. However, little is known about the role of Nuclear factor kB (NF-kB) activity-dependent P-selectin in ox-LDL-induced foam cell formation during atherosclerosis. In this study, we first investigated ox-LDL induced foam cell formation in the human U937 promonocytic cell line in a dose- and time-dependent manner. Treatment of U937 cells with ox-LDL increased lipid accumulation as well as intracellular cholesterol content. Next, a comparative analysis of gene expression profiling using cDNA microarray and Real-time-PCR indicated that ox-LDL exposure induced, in three treated groups, an extremely marked increase in the mRNA level of P-selectin. Protein levels of P-selectin and its upstream regulators IkBa and NF-kB showed that NF-kB pathway is involved in the ox-LDL-induced foam cell formation. Finally, overexpression of NF-kB significantly accelerated, whereas, inhibition of NF-kB with siRNA remarkably attenuated ox-LDL-induced macrophage-derived foam cell formation. It was concluded that the activity of NF-kB is augmented during macrophage-derived foam cell formation. Activation of NF-kB increased, whereas, inhibition of NF-kB decreased ox-LDL-induced P-selectin expression and lipid accumulation in macrophages, suggesting ox-LDL induced expression of P-selectin through degradation of IkBa and activation of NF-kB in the regulation of foam cell formation.

  2. Sanders, J. E.; and Merguerian, Charles, 1992a, Directional history of Pleistocene glaciers inferred from features eroded on bedrock, New York metropolitan area, SE NY.

    E-Print Network [OSTI]

    Merguerian, Charles

    Sanders, J. E.; and Merguerian, Charles, 1992a, Directional history of Pleistocene glaciers inferred from features eroded on bedrock, New York metropolitan area, SE NY. If a glacier erodes bedrock, the usual perception is that the youngest glacier will obliterate all direction-of-flow evidence that any

  3. Thermal Reactions of Uranium Metal, UO2, U3O8, UF4, and UO2F2 with NF3 to Produce UF6

    SciTech Connect (OSTI)

    McNamara, Bruce K.; Scheele, Randall D.; Kozelisky, Anne E.; Edwards, Matthew K.

    2009-11-01T23:59:59.000Z

    he objective of this paper is to demonstrate that NF3 fluorinates uranium metal, UO2, UF4, UO3, U3O8, and UO2F2•2H2O to produce the volatile UF6 at temperatures between 100 and 500?C. Thermogravimetric reaction profiles are described that reflect changes in the uranium oxidation state and discrete chemical speciation. Differences in the onset temperatures for each system indicate that NF3-substrate interactions are important for the temperature at which NF3 reacts: U metal > UO3 > UO2 > UO2F2 > UF4 and in fact may indicate different fluorination mechanisms for these various substrates. These studies demonstrate that NF3 is a potential replacement fluorinating agent in the existing nuclear fuel cycle and in oft-proposed actinide volatility reprocessing.

  4. 1 Managed by UT-Battelle for the U.S. Department of Energy NF/IDS Hg Vessel Layout 30 Jun 09

    E-Print Network [OSTI]

    McDonald, Kirk

    1 Managed by UT-Battelle for the U.S. Department of Energy NF/IDS Hg Vessel Layout 30 Jun 09 Cryostat 2 Front Drain Mercury Vessel Concept Matthew F. Glisson Van Graves #12;2 Managed by UT-Battelle;3 Managed by UT-Battelle for the U.S. Department of Energy NF/IDS Hg Vessel Layout 30 Jun 09 Cross Section

  5. Comparison of Daytime and Nighttime Populations Adjacent to Interstate Highways in Metropolitan Areas Using LandScan USA

    SciTech Connect (OSTI)

    Johnson, Paul E [ORNL] [ORNL

    2007-01-01T23:59:59.000Z

    An article of similar title was published in the International Journal of Radioactive Materials Transport in 1999. The study concluded that the daytime and nighttime populations are not substantially different for the metropolitan areas examined. This study revisits the issue, but using the LandScan USA high resolution population distribution data, which includes daytime and night-time population. Segments of Interstate highway beltways, along with the direct route through the city, for Atlanta, St. Louis, and Kansas City are examined with an 800m buffer from either side of the highways. The day/night ratio of population is higher using the LandScan USA data. LandScan USA daytime and night-time data will be incorporated into the TRAGIS routing model in future.

  6. Nmero Nome 1T 2T R1T R2T E AC NF 42200 Armando Dias

    E-Print Network [OSTI]

    Baia, Margarida

    Sheet1 Page 1 Número Nome 1T 2T R1T R2T E AC NF 42200 Armando Dias 53515 Jorge Branco 55774 João 70100 Catarina Ferreira 70146 Mariana Castro 70364 Nuno Gaspar 70524 António Grego 10 2 5 70934 João.2 2 15 78167 Afonso Sarmento 13.8 8.3 7.6 2 12 78175 Carlos Martins 14.3 12.6 11 2 14 78183 Ana

  7. Sulforaphane protects against cytokine- and streptozotocin-induced {beta}-cell damage by suppressing the NF-{kappa}B pathway

    SciTech Connect (OSTI)

    Song, Mi-Young; Kim, Eun-Kyung [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, 561-756 (Korea, Republic of); Moon, Woo-Sung [Department of Pathology, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, 561-756 (Korea, Republic of); Park, Jin-Woo [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, 561-756 (Korea, Republic of); Kim, Hyung-Jin; So, Hong-Seob; Park, Raekil [Vestibulocochlear System Research Center, College of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749 (Korea, Republic of); Kwon, Kang-Beom [Department of Physiology, School of Oriental Medicine, College of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749 (Korea, Republic of); Vestibulocochlear System Research Center, College of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749 (Korea, Republic of)], E-mail: desson@wonkwang.ac.kr; Park, Byung-Hyun [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, 561-756 (Korea, Republic of)], E-mail: bhpark@chonbuk.ac.kr

    2009-02-15T23:59:59.000Z

    Sulforaphane (SFN) is an indirect antioxidant that protects animal tissues from chemical or biological insults by stimulating the expression of several NF-E2-related factor-2 (Nrf2)-regulated phase 2 enzymes. Treatment of RINm5F insulinoma cells with SFN increases Nrf2 nuclear translocation and expression of phase 2 enzymes. In this study, we investigated whether the activation of Nrf2 by SFN treatment or ectopic overexpression of Nrf2 inhibited cytokine-induced {beta}-cell damage. Treatment of RIN cells with IL-1{beta} and IFN-{gamma} induced {beta}-cell damage through a NF-{kappa}B-dependent signaling pathway. Activation of Nrf2 by treatment with SFN and induction of Nrf2 overexpression by transfection with Nrf2 prevented cytokine toxicity. The mechanism by which Nrf2 activation inhibited NF-{kappa}B-dependent cell death signals appeared to involve the reduction of oxidative stress, as demonstrated by the inhibition of cytokine-induced H{sub 2}O{sub 2} production. The protective effect of SFN was further demonstrated by the restoration of normal insulin secreting responses to glucose in cytokine-treated rat pancreatic islets. Furthermore, pretreatment with SFN blocked the development of type 1 diabetes in streptozotocin-treated mice.

  8. Etching of UO{sub 2} in NF{sub 3} RF Plasma Glow Discharge

    SciTech Connect (OSTI)

    John M. Veilleux

    1999-08-01T23:59:59.000Z

    A series of room temperature, low pressure (10.8 to 40 Pa), low power (25 to 210 W) RF plasma glow discharge experiments with UO{sub 2} were conducted to demonstrate that plasma treatment is a viable method for decontaminating UO{sub 2} from stainless steel substrates. Experiments were conducted using NF{sub 3} gas to decontaminate depleted uranium dioxide from stainless-steel substrates. Depleted UO{sub 2} samples each containing 129.4 Bq were prepared from 100 microliter solutions of uranyl nitrate hexahydrate solution. The amorphous UO{sub 2} in the samples had a relatively low density of 4.8 gm/cm{sub 3}. Counting of the depleted UO{sub 2} on the substrate following plasma immersion was performed using liquid scintillation counting with alpha/beta discrimination due to the presence of confounding beta emitting daughter products, {sup 234}Th and {sup 234}Pa. The alpha emission peak from each sample was integrated using a gaussian and first order polynomial fit to improve quantification. The uncertainties in the experimental measurement of the etched material were estimated at about {+-} 2%. Results demonstrated that UO{sub 2} can be completely removed from stainless-steel substrates after several minutes processing at under 200 W. At 180 W and 32.7 Pa gas pressure, over 99% of all UO{sub 2} in the samples was removed in just 17 minutes. The initial etch rate in the experiments ranged from 0.2 to 7.4 {micro}m/min. Etching increased with the plasma absorbed power and feed gas pressure in the range of 10.8 to 40 Pa. A different pressure effect on UO{sub 2} etching was also noted below 50 W in which etching increased up to a maximum pressure, {approximately}23 Pa, then decreased with further increases in pressure.

  9. Renormalization of local quark-bilinear operators for Nf=3 flavors of SLiNC fermions

    E-Print Network [OSTI]

    M. Constantinou; R. Horsley; H. Panagopoulos; H. Perlt; P. E. L. Rakow; G. Schierholz; A. Schiller; J. M. Zanotti

    2014-08-26T23:59:59.000Z

    The renormalization factors of local quark-bilinear operators are computed non-perturbatively for $N_f=3$ flavors of SLiNC fermions, with emphasis on the various procedures for the chiral and continuum extrapolations. The simulations are performed at a lattice spacing $a=0.074$ fm, and for five values of the pion mass in the range of 290-465 MeV, allowing a safe and stable chiral extrapolation. Emphasis is given in the subtraction of the well-known pion pole which affects the renormalization factor of the pseudoscalar current. We also compute the inverse propagator and the Green's functions of the local bilinears to one loop in perturbation theory. We investigate lattice artifacts by computing them perturbatively to second order as well as to all orders in the lattice spacing. The renormalization conditions are defined in the RI$'$-MOM scheme, for both the perturbative and non-perturbative results. The renormalization factors, obtained at different values of the renormalization scale, are translated to the ${\\bar{\\rm MS}}$ scheme and are evolved perturbatively to 2 GeV. Any residual dependence on the initial renormalization scale is eliminated by an extrapolation to the continuum limit. We also study the various sources of systematic errors. Particular care is taken in correcting the non-perturbative estimates by subtracting lattice artifacts computed to one loop perturbation theory using the same action. We test two different methods, by subtracting either the ${\\cal O}(g^2\\,a^2)$ contributions, or the complete (all orders in $a$) one-loop lattice artifacts.

  10. Determination of c_sw in N_f=3+1 Lattice QCD with massive Wilson fermions

    E-Print Network [OSTI]

    Patrick Fritzsch; Rainer Sommer; Felix Stollenwerk; Ulli Wolff

    2015-01-27T23:59:59.000Z

    We develop a strategy for the non-perturbative determination of the O(a)-improvement coefficient c_sw for Wilson fermions with massive sea quarks. The improvement condition is defined via the PCAC relation in the Schr\\"odinger functional. It is imposed along a line of constant physics designed to be close to the correct mass of the charm quark. The numerical work uses the tree-level improved L\\"uscher-Weisz gauge action in N_f=3+1 Lattice QCD.

  11. A (P)HMC algorithm for N_f = 2 + 1 + 1 flavours of twisted mass fermions

    E-Print Network [OSTI]

    T. Chiarappa; R. Frezzotti; C. Urbach

    2005-09-27T23:59:59.000Z

    We present a detailed design of a (P)HMC simulation algorithm for N_f = 2 + 1 + 1 maximally twisted Wilson quark flavours. The algorithm retains even/odd and mass-shift preconditionings combined with multiple Molecular Dynamics time scales for both the light mass degenerate, u and d, quarks and the heavy mass non-degenerate, s and c, quarks. Various non-standard aspects of the algorithm are discussed, among which those connected to the use of a polynomial approximation for the inverse (square root of the squared) Dirac matrix in the s and c quark sector.

  12. Natural Proteasome Inhibitor Celastrol Suppresses Androgen-Independent Prostate Cancer Progression by Modulating Apoptotic Proteins and NF-kappaB

    E-Print Network [OSTI]

    Dai, Yao; Jeffrey, Tang; Wenhua, Xiaojie; Meng, Yang; Burstein, Ezra; Lawrence, Theodore S.; Xu, Liang

    2010-12-10T23:59:59.000Z

    Apoptotic Proteins and NF-kappaB. PLoS ONE 5(12): e14153. doi:10.1371/journal.pone.0014153 Editor: Gen Sheng Wu, Wayne State University, United States of America Received July 10, 2010; Accepted November 10, 2010; Published December 10, 2010 Copyright: #2... through a University of Michigan Cancer Center Support Grant [5 P30 CA46592]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared...

  13. NF-{kappa}B signaling is activated and confers resistance to apoptosis in three-dimensionally cultured EGFR-mutant lung adenocarcinoma cells

    SciTech Connect (OSTI)

    Sakuma, Yuji, E-mail: ysakuma@gancen.asahi.yokohama.jp [Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama (Japan)] [Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama (Japan); Yamazaki, Yukiko; Nakamura, Yoshiyasu; Yoshihara, Mitsuyo; Matsukuma, Shoichi; Koizume, Shiro; Miyagi, Yohei [Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama (Japan)] [Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama (Japan)

    2012-07-13T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer EGFR-mutant cells in 3D culture resist EGFR inhibition compared with suspended cells. Black-Right-Pointing-Pointer Degradation of I{kappa}B and activation of NF-{kappa}B are observed in 3D-cultured cells. Black-Right-Pointing-Pointer Inhibiting NF-{kappa}B enhances the efficacy of the EGFR inhibitor in 3D-cultured cells. -- Abstract: Epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma cells in suspension undergo apoptosis to a greater extent than adherent cells in a monolayer when EGFR autophosphorylation is inhibited by EGFR tyrosine kinase inhibitors (TKIs). This suggests that cell adhesion to a culture dish may activate an anti-apoptotic signaling pathway other than the EGFR pathway. Since the microenvironment of cells cultured in a monolayer are substantially different to that of cells existing in three-dimension (3D) in vivo, we assessed whether two EGFR-mutant lung adenocarcinoma cell lines, HCC827 and H1975, were more resistant to EGFR TKI-induced apoptosis when cultured in a 3D extracellular matrix (ECM) as compared with in suspension. The ECM-adherent EGFR-mutant cells in 3D were significantly less sensitive to treatment with WZ4002, an EGFR TKI, than the suspended cells. Further, a marked degradation of I{kappa}B{alpha}, the inhibitor of nuclear factor (NF)-{kappa}B, was observed only in the 3D-cultured cells, leading to an increase in the activation of NF-{kappa}B. Moreover, the inhibition of NF-{kappa}B with pharmacological inhibitors enhanced EGFR TKI-induced apoptosis in 3D-cultured EGFR-mutant cells. These results suggest that inhibition of NF-{kappa}B signaling would render ECM-adherent EGFR-mutant lung adenocarcinoma cells in vivo more susceptible to EGFR TKI-induced cell death.

  14. Determination of the running coupling constant $?_s$ for Nf=2+1 QCD with the Schroedinger functional scheme

    E-Print Network [OSTI]

    Yusuke Taniguchi; for the PACS-CS collaboration

    2009-10-27T23:59:59.000Z

    We present an evaluation of the running coupling constant and the quark mass renormalization factor for $N_f=2+1$ QCD. The Schr\\"odinger functional scheme is used as the intermediate scheme to carry out non-perturbative running from the low energy region, where physical input is introduced, to deep in the high energy perturbative region, where conversion to the ${\\ovl{\\rm MS}}$ scheme is safely performed. For numerical simulations we adopted Iwasaki gauge action and non-perturbatively improved Wilson fermion action with the clover term. Seven renormalization scales are used to cover from low to high energy region and three lattice spacings to take the continuum limit at each scale. Physical inputs are introduced from the previous $N_f=2+1$ simulation of the CP-PACS/JL-QCD collaboration, which covered the up-down quark mass range heavier than $m_\\pi\\sim 500$ MeV, and that of PACS-CS collaboration for much lighter quark masses down to $m_\\pi=155$ MeV.

  15. Angiotensin II modulates interleukin-1{beta}-induced inflammatory gene expression in vascular smooth muscle cells via interfering with ERK-NF-{kappa}B crosstalk

    SciTech Connect (OSTI)

    Xu, Shanqin [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States)] [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States); Zhi, Hui [Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States)] [Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States); Hou, Xiuyun [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States)] [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States); Jiang, Bingbing, E-mail: bjiang1@rics.bwh.harvard.edu [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States) [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States)

    2011-07-08T23:59:59.000Z

    Highlights: {yields} We examine how angiotensin II modulates ERK-NF-{kappa}B crosstalk and gene expression. {yields} Angiotensin II suppresses IL-1{beta}-induced prolonged ERK and NF-{kappa}B activation. {yields} ERK-RSK1 signaling is required for IL-1{beta}-induced prolonged NF-{kappa}B activation. {yields} Angiotensin II modulates NF-{kappa}B responsive genes via regulating ERK-NF-{kappa}B crosstalk. {yields} ERK-NF-{kappa}B crosstalk is a novel mechanism regulating inflammatory gene expression. -- Abstract: Angiotensin II is implicated in cardiovascular diseases, which is associated with a role in increasing vascular inflammation. The present study investigated how angiotensin II modulates vascular inflammatory signaling and expression of inducible nitric oxide synthase (iNOS) and vascular cell adhesion molecule (VCAM)-1. In cultured rat aortic vascular smooth muscle cells (VSMCs), angiotensin II suppressed interleukin-1{beta}-induced prolonged phosphorylation of extracellular signal-regulated kinase (ERK) and ribosomal S6 kinase (RSK)-1, and nuclear translocation of nuclear factor (NF)-{kappa}B, leading to decreased iNOS but enhanced VCAM-1 expression, associated with an up-regulation of mitogen-activated protein kinase phosphatase-1 expression. Knock-down of RSK1 selectively down regulated interleukin-1{beta}-induced iNOS expression without influencing VCAM-1 expression. In vivo experiments showed that interleukin-1{beta}, iNOS, and VCAM-1 expression were detectable in the aortic arches of both wild-type and apolipoprotein E-deficient (ApoE{sup -/-}) mice. VCAM-1 and iNOS expression were higher in ApoE{sup -/-} than in wild type mouse aortic arches. Angiotensin II infusion (3.2 mg/kg/day, for 6 days, via subcutaneous osmotic pump) in ApoE{sup -/-} mice enhanced endothelial and adventitial VCAM-1 and iNOS expression, but reduced medial smooth muscle iNOS expression associated with reduced phosphorylation of ERK and RSK-1. These results indicate that angiotensin II can differentially modulate inflammatory gene expression in aortic smooth muscle cells through influencing ERK-NF-{kappa}B crosstalk, which may contribute to angiotensin II-induced inflammatory disorders related to cardiovascular diseases.

  16. Community air pollution and mortality: Analysis of 1980 data from US metropolitan areas. 1: Particulate air pollution

    SciTech Connect (OSTI)

    Lipfert, F.W.

    1992-11-01T23:59:59.000Z

    1980 data from up to 149 metropolitan areas were used to define cross-sectional associations between community air pollution and excess human mortality. The regression model proposed by Oezkaynak and Thurston, which accounted for age, race, education, poverty, and population density, was evaluated and several new models were developed. The new models also accounted for population change, drinking water hardness, and smoking, and included a more detailed description of race. Cause-of-death categories analyzed include all causes, all non-external causes, major cardiovascular diseases, and chronic obstructive pulmonary diseases (COPD). Both annual mortality rates and their logarithms were analyzed. The data on particulates were averaged across all monitoring stations available for each SMSA and the TSP data were restricted to the year 1980. The associations between mortality and air pollution were found to be dependent on the socioeconomic factors included in the models, the specific locations included din the data set, and the type of statistical model used. Statistically significant associations were found between TSP and mortality due to non-external causes with log-linear models, but not with a linear model, and between TS and COPD mortality for both linear and log-linear models. When the sulfate contribution to TSP was subtracted, the relationship with COPD mortality was strengthened. Scatter plots and quintile analyses suggested a TSP threshold for COPD mortality at around 65 ug/m{sup 3} (annual average). SO{sub 4}{sup {minus}2}, Mn, PM{sup 15}, and PM{sub 2.5} were not significantly associated with mortality using the new models.

  17. Apolipoprotein E inhibits osteoclast differentiation via regulation of c-Fos, NFATc1 and NF-?B

    SciTech Connect (OSTI)

    Kim, Woo-Shin; Kim, Hyung Joon; Lee, Zang Hee [Department of Cell and Developmental Biology, BK21 Program and Dental Research Institute, Seoul National University, 28 Yeongon-Dong, Chongno-Gu, Seoul 110-749 (Korea, Republic of); Lee, Youngkyun [Department of Biochemistry, School of Dentistry, Kyungpook National University, Daegu 700-422 (Korea, Republic of); Kim, Hong-Hee, E-mail: hhbkim@snu.ac.kr [Department of Cell and Developmental Biology, BK21 Program and Dental Research Institute, Seoul National University, 28 Yeongon-Dong, Chongno-Gu, Seoul 110-749 (Korea, Republic of)

    2013-02-15T23:59:59.000Z

    Apolipoprotein E (ApoE) plays a major role in the transport and metabolism of lipid. Other functions of ApoE include modulation of innate and adaptive immune responses. The expression of ApoE in osteoblasts and its relevance with bone formation have also been reported. However, the effect of ApoE on osteoclasts has not yet been examined. Here, we investigated the role of ApoE in osteoclast differentiation using bone marrow-derived macrophages (BMMs) and RAW264.7 cells. We found a down-regulation of ApoE gene expression during osteoclastic differentiation of those cells. Overexpression of ApoE in BMMs and RAW264.7 cells significantly blocked the induction of c-Fos and nuclear factor of activated T cell c1 (NFATc1), transcription factors critical for expression of osteoclast marker genes, by receptor activator of nuclear factor ?B ligand (RANKL), the osteoclast differentiation factor. ApoE inhibited osteoclast differentiation, as measured by decreased number of tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cells (MNCs). In addition, ApoE reduced the expression of dendritic cell-specific transmembrane protein (DC-STAMP) and ATPase, H{sup +} transporting, lysosomal 38 kDa, V0 subunit d2 (ATP6v0d2), genes involved in cell–cell fusion during osteoclastogenesis. Knock-down of ApoE using a specific siRNA promoted the RANKL-mediated induction of osteoclast differentiation. While ApoE did not affect the activation of ERK, JNK, and p38 MAPK signaling pathways by RANKL, the phosphorylation of p65 trans-activation domain on serine 536 and transcription activity of NF-?B were reduced by ApoE overexpression. These findings suggest that ApoE plays an inhibitory role in osteoclast differentiation via the suppression of RANKL-dependent activation of NF-?B and induction of c-Fos and NFATc1. - Highlights: ? Apolipoprotein E (ApoE) significantly inhibited osteoclast differentiation and activation of NF-?B. ? ApoE decreased the induction of osteoclast marker genes such as c-Fos, NFATc1, TRAP, DC-STAMP and Cathepsin K. ? ApoE reduced number of TRAP-positive multinuclear cells. ? Exogenous ApoE inhibits osteoclast formation by reduction of crucial factor of osteoclast differentiation. ? knock-down of ApoE promoted the RANKL-mediated induction of osteoclast differentiation.

  18. GRP94/gp96 Elicits ERK Activation in Murine Macrophages A ROLE FOR ENDOTOXIN CONTAMINATION IN NF-B ACTIVATION AND NITRIC OXIDE PRODUCTION*

    E-Print Network [OSTI]

    Nicchitta, Chris

    GRP94/gp96 Elicits ERK Activation in Murine Macrophages A ROLE FOR ENDOTOXIN CONTAMINATION IN NF- B signaling and ni- tric oxide production, as well as the MAP kinase p38, JNK, and ERK signaling cascades a marked increase in ERK phosphorylation at protein concentrations as low as 2 g/ml. These results

  19. Differential Effects of ?-catenin and NF-?B Interplay in the Regulation of Cell Proliferation, Inflammation and Tumorigenesis in Response to Bacterial Infection

    E-Print Network [OSTI]

    Chandrakesan, Parthasarathy; Jakkula, Laxmi Uma Maheswar Rao; Ahmed, Ishfaq; Roy, Badal; Anant, Shrikant; Umar, Shahid

    2013-11-21T23:59:59.000Z

    Both ?-catenin and NF-?B have been implicated in our laboratory as candidate factors in driving proliferation in an in vivo model of Citrobacter rodentium (CR)-induced colonic crypt hyper-proliferation and hyperplasia. Herein, we test the hypothesis...

  20. Spontaneous transition of core radial electric field driven by magnetic islands in the H-1NF heliac

    SciTech Connect (OSTI)

    Kumar, S. T. A. [University of Wisconsin, Madison; Blackwell, B. D. [Australian National University, Canberra, Australia; Howard, J. [Australian National University, Canberra, Australia; Harris, J. H. [Oak Ridge National Laboratory (ORNL)

    2011-01-01T23:59:59.000Z

    This paper reports an experimental observation of spontaneous transition of the core radial electric field to a large positive value (E(r) similar to 5 kV m(-1)), with a strong electric-field shear (similar to 700 kV m(-2)) in a low temperature (T(e) similar to 10 eV) radio frequency generated argon plasma in the H-1NF heliac stellarator. The transition, which seems to be driven by a spontaneous excitation of m = 2 magnetic islands near the core, is associated with a localized increase in the plasma density and excitation of coherent low frequency (similar to 3 kHz) oscillations possibly due to unstable E(r) shear driven modes. Evidence suggests development of the core electron-root scenario, which previously has been observed only at high temperature electron cyclotron heated plasmas.

  1. Absolute frequency measurements of 85Rb nF7/2 Rydberg states using purely optical detection

    E-Print Network [OSTI]

    L. A. M. Johnson; H. O. Majeed; B. Sanguinetti; Th. Becker; B. T. H. Varcoe

    2010-02-16T23:59:59.000Z

    A three-step laser excitation scheme is used to make absolute frequency measurements of highly excited nF7/2 Rydberg states in 85Rb for principal quantum numbers n=33-100. This work demonstrates the first absolute frequency measurements of rubidium Rydberg levels using a purely optical detection scheme. The Rydberg states are excited in a heated Rb vapour cell and Doppler free signals are detected via purely optical means. All of the frequency measurements are made using a wavemeter which is calibrated against a GPS disciplined self-referenced optical frequency comb. We find that the measured levels have a very high frequency stability, and are especially robust to electric fields. The apparatus has allowed measurements of the states to an accuracy of 8.0MHz. The new measurements are analysed by extracting the modified Rydberg-Ritz series parameters.

  2. Magnetic susceptibility and equation of state of N_f = 2+1 QCD with physical quark masses

    E-Print Network [OSTI]

    Claudio Bonati; Massimo D'Elia; Marco Mariti; Francesco Negro; Francesco Sanfilippo

    2014-05-13T23:59:59.000Z

    We determine the free energy of strongly interacting matter as a function of an applied constant and uniform magnetic field. We consider N_f = 2+1 QCD with physical quark masses, discretized on a lattice by stout improved staggered fermions and a tree level improved Symanzik pure gauge action, and explore three different lattice spacings. For magnetic fields of the order of those produced in non-central heavy ion collisions (eB ~ 0.1 GeV^2) strongly interacting matter behaves like a medium with a linear response, and is paramagnetic both above and below the deconfinement transition, with a susceptibility which steeply rises in the deconfined phase. We compute the equation of state, showing that the relative increase in the pressure due to the magnetic field gets larger around the transition, and of the order of 10 % for eB ~ 0.1 GeV^2.

  3. Metastatic function of BMP-2 in gastric cancer cells: The role of PI3K/AKT, MAPK, the NF-{kappa}B pathway, and MMP-9 expression

    SciTech Connect (OSTI)

    Kang, Myoung Hee [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Oh, Sang Cheul [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Lee, Hyun Joo [Department of Pathology, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Department of Pathology, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Kang, Han Na; Kim, Jung Lim [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Kim, Jun Suk [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Yoo, Young A., E-mail: ydanbi@korea.ac.kr [Brain Korea 21 Program for Biomedical Science, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)

    2011-07-15T23:59:59.000Z

    Bone morphogenetic proteins (BMPs) have been implicated in tumorigenesis and metastatic progression in various types of cancer cells, but the role and cellular mechanism in the invasive phenotype of gastric cancer cells is not known. Herein, we determined the roles of phosphoinositide 3-kinase (PI3K)/AKT, extracellular signal-regulated protein kinase (ERK), nuclear factor (NF)-{kappa}B, and matrix metalloproteinase (MMP) expression in BMP-2-mediated metastatic function in gastric cancer. We found that stimulation of BMP-2 in gastric cancer cells enhanced the phosphorylation of AKT and ERK. Accompanying activation of AKT and ERK kinase, BMP-2 also enhanced phosphorylation/degradation of I{kappa}B{alpha} and the nuclear translocation/activation of NF-{kappa}B. Interestingly, blockade of PI3K/AKT and ERK signaling using LY294002 and PD98059, respectively, significantly inhibited BMP-2-induced motility and invasiveness in association with the activation of NF-{kappa}B. Furthermore, BMP-2-induced MMP-9 expression and enzymatic activity was also significantly blocked by treatment with PI3K/AKT, ERK, or NF-{kappa}B inhibitors. Immunohistochemistry staining of 178 gastric tumor biopsies indicated that expression of BMP-2 and MMP-9 had a significant positive correlation with lymph node metastasis and a poor prognosis. These results indicate that the BMP-2 signaling pathway enhances tumor metastasis in gastric cancer by sequential activation of the PI3K/AKT or MAPK pathway followed by the induction of NF-{kappa}B and MMP-9 activity, indicating that BMP-2 has the potential to be a therapeutic molecular target to decrease metastasis.

  4. Trap cultures reveal higher species richness of arbuscular mycorrhizal fungi in comparison to soil samples in the Phoenix metropolitan area.Arbuscular mycorrhizal fungal and dark septate endophytes colonization of plant roots from urban desert preserves a

    E-Print Network [OSTI]

    Hall, Sharon J.

    samples in the Phoenix metropolitan area.Arbuscular mycorrhizal fungal and dark septate endophytes mycorrhizal fungal and dark septate endophytes colonization of plant roots from urban desert preserves (Brundett 1999). Dark septate endophytes (DSE) are another type of root colonizing fungi mainly classified

  5. MANCHESTER METROPOLITAN Financial Statements

    E-Print Network [OSTI]

    (includes share of associated company's result) (199,979) (185,386) Impairment on properties in an impairment charge of £7.7m The University has during the past year been planning the implementation of six seven campus areas down to three and will ensure the University has a sustainable estate for the future

  6. Lubbock Metropolitan Transportation Plan

    E-Print Network [OSTI]

    Lubbock Metropolitan Planning Organization

    2007-09-18T23:59:59.000Z

    for Users (SAFETEA-LU) and its predecessors, the Transportation Equity Act for the 21st Century (TEA-21) and the Intermodal Surface Transportation Efficiency Act (ISTEA) of 1991, specified the transportation systems on which certain federal funds can... in Chapter 5 ? Streets and Highways; Chapter 6 ? Public Transportation; Chapter 7 ? Bicycle and Pedestrian Plan; Chapter 8 ? Lubbock International Airport and Chapter 9 ? Railroads and Trucking. Federally funded transit projects were developed...

  7. Manchester Metropolitan University Sustainability

    E-Print Network [OSTI]

    key technologies such as rainwater harvesting and grey water systems to reduce our water usage & Healthy Buildings Water savings · We've reduced our yearly water consumption by 12.1%. · We've utilised of the most visibly sustainable in Manchester city centre. 2,592,000 Ltr Water Management Biodiversity 39 #12

  8. Metropolitan problems in Texas

    E-Print Network [OSTI]

    Pearson, William Morris

    1965-01-01T23:59:59.000Z

    , the fifty state govern- ments, and 56, 507 local governments other than school districts: 3)043 counties, 17, 997 municipalities, 17, 144 townships, and. 18, 323 special districts. The average number of governmental units per state was 1, 825. However... Counties Municipalities Townships and towns School districts Special districts Total 1 50 17, 997 17, 144 34, 678 18, 323 91, 236 1 50 3)050 17)251 17, 198 50, 454 14, 424 102, 392 1 50 3) 052 16, 807 17)202 67, 355 12, 340 116...

  9. Characterization of Fine Particulate Matter (PM) and Secondary PM Precursor Gases in the Mexico City Metropolitan Area

    SciTech Connect (OSTI)

    Luisa T. Molina, Rainer Volkamer, Benjamin de Foy, Wenfang Lei, Miguel Zavala, Erik Velasco; Mario J. Molina

    2008-10-31T23:59:59.000Z

    This project was one of three collaborating grants funded by DOE/ASP to characterize the fine particulate matter (PM) and secondary PM precursors in the Mexico City Metropolitan Area (MCMA) during the MILAGRO Campaign. The overall effort of MCMA-2006, one of the four components, focused on i) examination of the primary emissions of fine particles and precursor gases leading to photochemical production of atmospheric oxidants and secondary aerosol particles; ii) measurement and analysis of secondary oxidants and secondary fine PM production, with particular emphasis on secondary organic aerosol (SOA), and iii) evaluation of the photochemical and meteorological processes characteristic of the Mexico City Basin. The collaborative teams pursued the goals through three main tasks: i) analyses of fine PM and secondary PM precursor gaseous species data taken during the MCMA-2002/2003 campaigns and preparation of publications; ii) planning of the MILAGRO Campaign and deployment of the instrument around the MCMA; and iii) analysis of MCMA-2006 data and publication preparation. The measurement phase of the MILAGRO Campaign was successfully completed in March 2006 with excellent participation from the international scientific community and outstanding cooperation from the Mexican government agencies and institutions. The project reported here was led by the Massachusetts Institute of Technology/Molina Center for Energy and the Environment (MIT/MCE2) team and coordinated with DOE/ASP-funded collaborators at Aerodyne Research Inc., University of Colorado at Boulder and Montana State University. Currently 24 papers documenting the findings from this project have been published. The results from the project have improved significantly our understanding of the meteorological and photochemical processes contributing to the formation of ozone, secondary aerosols and other pollutants. Key findings from the MCMA-2003 include a vastly improved speciated emissions inventory from on-road vehicles: the MCMA motor vehicles produce abundant amounts of primary PM, elemental carbon, particle-bound polycyclic aromatic hydrocarbons, carbon monoxide and a wide range of air toxics; the feasibility of using eddy covariance techniques to measure fluxes of volatile organic compounds in an urban core and a valuable tool for validating local emissions inventory; a much better understanding of the sources and atmospheric loadings of volatile organic compounds; the first spectroscopic detection of glyoxal in the atmosphere; a unique analysis of the high fraction of ambient formaldehyde from primary emission sources; characterization of ozone formation and its sensitivity to VOCs and NOx; a much more extensive knowledge of the composition, size distribution and atmospheric mass loadings of both primary and secondary fine PM, including the fact that the rate of MCMA SOA production greatly exceeded that predicted by current atmospheric models; evaluations of significant errors that can arise from standard air quality monitors for O3 and NO2; and the implementation of an innovative Markov Chain Monte Carlo method for inorganic aerosol modeling as a powerful tool to analyze aerosol data and predict gas phase concentrations where these are unavailable. During the MILAGRO Campaign the collaborative team utilized a combination of central fixed sites and a mobile laboratory deployed throughout the MCMA to representative urban and boundary sites to measure trace gases and fine particles. Analysis of the extensive 2006 data sets has confirmed the key findings from MCMA-2002/2003; additionally MCMA-2006 provided more detailed gas and aerosol chemistry and wider regional scale coverage. Key results include an updated 2006 emissions inventory; extension of the flux system to measure fluxes of fine particles; better understanding of the sources and apportionment of aerosols, including contribution from biomass burning and industrial sources; a comprehensive evaluation of metal containing particles in a complex urban environment; identification of a close correlation between

  10. Inhibition of inflammatory mediators contributes to the anti-inflammatory activity of KYKZL-1 via MAPK and NF-?B pathway

    SciTech Connect (OSTI)

    Xu, Guang-Lin [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Department of Pharmacology, University of Michigan, Ann Arbor (United States); Du, Yi-Fang; Cheng, Jing; Huan, Lin [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Chen, Shi-Cui [Jinhu Food and Drug Administration, Jiangsu (China); Wei, Shao-Hua [College of Chemistry and Materials Science, Nanjing Normal University, Nanjing (China); Gong, Zhu-Nan, E-mail: biopharmacology@126.com [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Cai, Jie; Qiu, Ting; Wu, Hao; Sun, Ting [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Ao, Gui-Zhen [Department of Medicinal Chemistry, School of Pharmacy, Soochow University, Jiangsu (China)

    2013-10-01T23:59:59.000Z

    KYKZL-1, a newly synthesized compound with COX/5-LOX dual inhibition, was subjected to the anti-inflammatory activity test focusing on its modulation of inflammatory mediators as well as intracellular MAPK and NF-?B signaling pathways. In acute ear edema model, pretreatment with KYKZL-1 (p.o.) dose-dependently inhibited the xylene-induced ear edema in mice with a higher inhibition than diclofenac. In a three-day TPA-induced inflammation, KYKZL-1 also showed significant anti-inflammatory activity with inhibition ranging between 20% and 64%. In gastric lesion test, KYKZL-1 elicited markedly fewer stomach lesions with a low index of ulcer as compared to diclofenac in rats. In further studies, KYKZL-1 was found to significantly inhibit the production of NO, PGE{sub 2}, LTB{sub 4} in LPS challenged RAW264.7, which is parallel to its attenuation of the expression of iNOS, COX-2, 5-LOX mRNAs or proteins and inhibition of phosphorylation of p38 and ERK MAPKs and activation of NF-?B. Taken together, our data indicate that KYKZL-1 comprises dual inhibition of COX and 5-LOX and exerts an obvious anti-inflammatory activity with an enhanced gastric safety profile via simultaneous inhibition of phosphorylation of p38 and ERK MAPKs and activation of NF-?B. - Highlights: • KYKZL-1 is designed to exhibit COX/5-LOX dual inhibition. • KYKZL-1 inhibits NO, PGE{sub 2} and LTB{sub 4} and iNOS, COX-2 and 5-LOX mRNAs and MAPKs. • KYKZL-1 inhibits phosphorylation of MAPKs. • KYKZL-1 inactivates NF-?B pathway.

  11. Carbachol ameliorates lipopolysaccharide-induced intestinal epithelial tight junction damage by down-regulating NF-{kappa}{beta} and myosin light-chain kinase pathways

    SciTech Connect (OSTI)

    Zhang, Ying [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China)] [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China); Li, Jianguo, E-mail: 2010lijianguo@sina.cn [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China)] [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China)

    2012-11-16T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Carbachol reduced the lipopolysaccharide-induced intestinal barrier breakdown. Black-Right-Pointing-Pointer Carbachol ameliorated the lipopolysaccharide-induced ileal tight junction damage. Black-Right-Pointing-Pointer Carbachol prevented the LPS-induced NF-{kappa}{beta} and myosin light-chain kinase activation. Black-Right-Pointing-Pointer Carbachol exerted its beneficial effects in an {alpha}7 nicotinic receptor-dependent manner. -- Abstract: Carbachol is a cholinergic agonist that protects the intestines after trauma or burn injury. The present study determines the beneficial effects of carbachol and the mechanisms by which it ameliorates the lipopolysaccharide (LPS)-induced intestinal barrier breakdown. Rats were injected intraperitoneally with 10 mg/kg LPS. Results showed that the gut barrier permeability was reduced, the ultrastructural disruption of tight junctions (TJs) was prevented, the redistribution of zonula occludens-1 and claudin-2 proteins was partially reversed, and the nuclear factor-kappa beta (NF-{kappa}{beta}) and myosin light-chain kinase (MLCK) activation in the intestinal epithelium were suppressed after carbachol administration in LPS-exposed rats. Pretreatment with the {alpha}7 nicotinic acetylcholine receptor ({alpha}7nAchR) antagonist {alpha}-bungarotoxin blocked the protective action of carbachol. These results suggested that carbachol treatment can protect LPS-induced intestinal barrier dysfunction. Carbachol exerts its beneficial effect on the amelioration of the TJ damage by inhibiting the NF-{kappa}{beta} and MLCK pathways in an {alpha}7nAchR-dependent manner.

  12. Broken Valence Chiral Symmetry and Chiral Polarization of Dirac Spectrum in N$_f$=12 QCD at Small Quark Mass

    E-Print Network [OSTI]

    Andrei Alexandru; Ivan Horváth

    2014-12-04T23:59:59.000Z

    The validity of recently proposed equivalence between valence spontaneous chiral symmetry breaking (vSChSB) and chiral polarization of low energy Dirac spectrum (ChP) in SU(3) gauge theory, is examined for the case of twelve mass-degenerate fundamental quark flavors. We find that the vSChSB-ChP correspondence holds for regularized systems studied. Moreover, our results suggest that vSChSB occurs in two qualitatively different circumstances: there is a quark mass $m_c$ such that for $m > m_c$ the mode condensing Dirac spectrum exhibits standard monotonically increasing density, while for $m_{ch} < m < m_c$ the peak around zero separates from the bulk of the spectrum, with density showing a pronounced depletion at intermediate scales. Valence chiral symmetry restoration may occur at yet smaller masses $m < m_{ch}$, but this has not yet been seen by overlap valence probe, leaving the $m_{ch}=0$ possibility open. The latter option could place massless N$_f$=12 theory outside of conformal window. Anomalous behavior of overlap Dirac spectrum for $m_{ch} < m < m_c$ is qualitatively similar to one observed previously in zero and few-flavor theories as an effect of thermal agitation.

  13. Up, down, strange and charm quark masses with Nf = 2+1+1 twisted mass lattice QCD

    E-Print Network [OSTI]

    N. Carrasco; A. Deuzeman; P. Dimopoulos; R. Frezzotti; V. Gimenez; G. Herdoiza; P. Lami; V. Lubicz; D. Palao; E. Picca; S. Recker; L. Riggio; G. C. Rossi; F. Sanfilippo; L. Scorzato; S. Simula; C. Tarantino; C. Urbach; U. Wenger

    2014-08-21T23:59:59.000Z

    We present a lattice QCD calculation of the up, down, strange and charm quark masses performed using the gauge configurations produced by the European Twisted Mass Collaboration with Nf = 2 + 1 + 1 dynamical quarks, which include in the sea, besides two light mass degenerate quarks, also the strange and charm quarks with masses close to their physical values. The simulations are based on a unitary setup for the two light quarks and on a mixed action approach for the strange and charm quarks. The analysis uses data at three values of the lattice spacing and pion masses in the range 210 - 450 MeV, allowing for accurate continuum limit and controlled chiral extrapolation. The quark mass renormalization is carried out non-perturbatively using the RI-MOM method. The results for the quark masses converted to the bar{MS} scheme are: mud(2 GeV) = 3.70(17) MeV, ms(2 GeV) = 99.6(4.3) MeV and mc(mc) = 1.348(46) GeV. We obtain also the quark mass ratios ms/mud = 26.66(32) and mc/ms = 11.62(16). By studying the mass splitting between the neutral and charged kaons and using available lattice results for the electromagnetic contributions, we evaluate mu/md = 0.470(56), leading to mu = 2.36(24) MeV and md = 5.03(26) MeV.

  14. Rosiglitazone attenuates NF-{kappa}B-dependent ICAM-1 and TNF-{alpha} production caused by homocysteine via inhibiting ERK{sub 1/2}/p38MAPK activation

    SciTech Connect (OSTI)

    Bai, Yong-Ping [Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China); Liu, Yu-Hui [Department of Pharmacology, College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330006 (China); Chen, Jia [Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China); Song, Tao [Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078 (China); You, Yu [Department of Digestive Medicine, Xiangya Second Hospital, Central South University, Changsha, Hunan 410078 (China); Tang, Zhen-Yan [Department of Urologic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China); Li, Yuan-Jian [Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078 (China); Zhang, Guo-Gang [Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China)]. E-mail: xyzgg2006@sina.com

    2007-08-17T23:59:59.000Z

    Previous studies demonstrated an important interaction between nuclear factor-kappaB (NF-{kappa}B) activation and homocysteine (Hcy)-induced cytokines expression in endothelial cells and vascular smooth muscle cells. However, the underlying mechanism remains illusive. In this study, we investigated the effects of Hcy on NF-{kappa}B-mediated sICAM-1, TNF-{alpha} production and the possible involvement of ERK{sub 1/2}/p38MAPK pathway. The effects of rosiglitazone intervention were also examined. Our results show that Hcy increased the levels of sICAM-1 and TNF-{alpha} in cultured human umbilical vein endothelial cells (HUVECs) in a time- and concentration-dependent manner. This effect was significantly depressed by rosiglitazone and different inhibitors (PDTC, NF-{kappa}B inhibitor; PD98059, MEK inhibitor; SB203580, p38MAPK specific inhibitor; and staurosporine, PKC inhibitor). Next, we investigated the effect of Hcy on ERK{sub 1/2}/p38MAPK pathway and NF-{kappa}B activity in HUVECs. The results show that Hcy activated both ERK{sub 1/2}/p38MAPK pathway and NF-{kappa}B-DNA-binding activity. These effects were markedly inhibited by rosiglitazone as well as other inhibitors (SB203580, PD98059, and PDTC). Further, the pretreatment of staurosporine abrogated ERK{sub 1/2}/p38MAPK phosphorylation, suggesting that Hcy-induced ERK{sub 1/2}/p38MAPK activation is associated with PKC activity. Our results provide evidence that Hcy-induced NF-{kappa}B activation was mediated by activation of ERK{sub 1/2}/p38MAPK pathway involving PKC activity. Rosiglitazone reduces the NF-{kappa}B-mediated sICAM-1 and TNF-{alpha} production induced by Hcy via inhibition of ERK{sub 1/2}/p38MAPK pa0011thw.

  15. Anti-neuroinflammatory efficacy of the aldose reductase inhibitor FMHM via phospholipase C/protein kinase C-dependent NF-?B and MAPK pathways

    SciTech Connect (OSTI)

    Zeng, Ke-Wu [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191 (China); Li, Jun [Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029 (China); Dong, Xin; Wang, Ying-Hong; Ma, Zhi-Zhong; Jiang, Yong; Jin, Hong-Wei [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191 (China); Tu, Peng-Fei, E-mail: pengfeitu@vip.163.com [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191 (China); Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029 (China)

    2013-11-15T23:59:59.000Z

    Aldose reductase (AR) has a key role in several inflammatory diseases: diabetes, cancer and cardiovascular diseases. Therefore, AR inhibition seems to be a useful strategy for anti-inflammation therapy. In the central nervous system (CNS), microglial over-activation is considered to be a central event in neuroinflammation. However, the effects of AR inhibition in CNS inflammation and its underlying mechanism of action remain unknown. In the present study, we found that FMHM (a naturally derived AR inhibitor from the roots of Polygala tricornis Gagnep.) showed potent anti-neuroinflammatory effects in vivo and in vitro by inhibiting microglial activation and expression of inflammatory mediators. Mechanistic studies showed that FMHM suppressed the activity of AR-dependent phospholipase C/protein kinase C signaling, which further resulted in downstream inactivation of the I?B kinase/I?B/nuclear factor-kappa B (NF-?B) inflammatory pathway. Therefore, AR inhibition-dependent NF-?B inactivation negatively regulated the transcription and expression of various inflammatory genes. AR inhibition by FMHM exerted neuroprotective effects in lipopolysaccharide-induced neuron–microglia co-cultures. These findings suggested that AR is a potential target for neuroinflammation inhibition and that FMHM could be an effective agent for treating or preventing neuroinflammatory diseases. - Highlights: • FMHM is a natural-derived aldose reductase (AR) inhibitor. • FMHM inhibits various neuroinflammatory mediator productions in vitro and in vivo. • FMHM inhibits neuroinflammation via aldose reductase/PLC/PKC-dependent NF-?B pathway. • FMHM inhibits neuroinflammation via aldose reductase/PLC/PKC-dependent MAPK pathway. • FMHM protects neurons against inflammatory injury in microglia-neuron co-cultures.

  16. Impaired NFAT and NF?B activation are involved in suppression of CD40 ligand expression by ?{sup 9}-tetrahydrocannabinol in human CD4{sup +} T cells

    SciTech Connect (OSTI)

    Ngaotepprutaram, Thitirat [Department of Pharmacology and Toxicology, Michigan State University (United States); Center for Integrative Toxicology, Michigan State University (United States); Kaplan, Barbara L.F. [Department of Pharmacology and Toxicology, Michigan State University (United States); Center for Integrative Toxicology, Michigan State University (United States); Neuroscience Program, Michigan State University (United States); Kaminski, Norbert E., E-mail: kamins11@msu.edu [Department of Pharmacology and Toxicology, Michigan State University (United States); Center for Integrative Toxicology, Michigan State University (United States)

    2013-11-15T23:59:59.000Z

    We have previously reported that ?{sup 9}-tetrahydrocannabinol (?{sup 9}-THC), the main psychoactive cannabinoid in marijuana, suppresses CD40 ligand (CD40L) expression by activated mouse CD4{sup +} T cells. CD40L is involved in pathogenesis of many autoimmune and inflammatory diseases. In the present study, we investigated the molecular mechanism of ?{sup 9}-THC-mediated suppression of CD40L expression using peripheral blood human T cells. Pretreatment with ?{sup 9}-THC attenuated CD40L expression in human CD4{sup +} T cells activated by anti-CD3/CD28 at both the protein and mRNA level, as determined by flow cytometry and quantitative real-time PCR, respectively. Electrophoretic mobility shift assays revealed that ?{sup 9}-THC suppressed the DNA-binding activity of both NFAT and NF?B to their respective response elements within the CD40L promoter. An assessment of the effect of ?{sup 9}-THC on proximal T cell-receptor (TCR) signaling induced by anti-CD3/CD28 showed significant impairment in the rise of intracellular calcium, but no significant effect on the phosphorylation of ZAP70, PLC?1/2, Akt, and GSK3?. Collectively, these findings identify perturbation of the calcium-NFAT and NF?B signaling cascade as a key mechanistic event by which ?{sup 9}-THC suppresses human T cell function. - Highlights: • ?{sup 9}-THC attenuated CD40L expression in activated human CD4+ T cells. • ?{sup 9}-THC suppressed DNA-binding activity of NFAT and NF?B. • ?{sup 9}-THC impaired elevation of intracellular Ca2+. • ?{sup 9}-THC did not affect phosphorylation of ZAP70, PLC?1/2, Akt, and GSK3?.

  17. The NSVZ beta-function and the Schwinger-Dyson equations for N=1 SQED with N_f flavors, regularized by higher derivatives

    E-Print Network [OSTI]

    K. V. Stepanyantz

    2014-06-08T23:59:59.000Z

    The effective diagram technique based on the Schwinger-Dyson equations is constructed for N=1 SQED with N_f flavors, regularized by higher derivatives. Using these effective diagrams, it is possible to derive the exact NSVZ relation between the beta-function and the anomalous dimension of the matter superfields exactly in all loops, if the renormalization group functions are defined in terms of the bare coupling constant. In particular, we verify that all integrals which give the beta-function defined in terms of the bare coupling constant are integrals of double total derivatives and prove some identities relating Green functions.

  18. OSU-A9 inhibits angiogenesis in human umbilical vein endothelial cells via disrupting Akt–NF-?B and MAPK signaling pathways

    SciTech Connect (OSTI)

    Omar, Hany A. [Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210 (United States); Department of Pharmacology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514 (Egypt); Arafa, El-Shaimaa A. [Department of Pharmacology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514 (Egypt); Salama, Samir A. [Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11511 (Egypt); Arab, Hany H. [Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo 11562 (Egypt); Wu, Chieh-Hsi, E-mail: chhswu@mail.cmu.edu.tw [School of Pharmacy, China Medical University, Taichung 40402, Taiwan (China); Weng, Jing-Ru, E-mail: columnster@gmail.com [Department of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan (China)

    2013-11-01T23:59:59.000Z

    Since the introduction of angiogenesis as a useful target for cancer therapy, few agents have been approved for clinical use due to the rapid development of resistance. This problem can be minimized by simultaneous targeting of multiple angiogenesis signaling pathways, a potential strategy in cancer management known as polypharmacology. The current study aimed at exploring the anti-angiogenic activity of OSU-A9, an indole-3-carbinol-derived pleotropic agent that targets mainly Akt–nuclear factor-kappa B (NF-?B) signaling which regulates many key players of angiogenesis such as vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). Human umbilical vein endothelial cells (HUVECs) were used to study the in vitro anti-angiogenic effect of OSU-A9 on several key steps of angiogenesis. Results showed that OSU-A9 effectively inhibited cell proliferation and induced apoptosis and cell cycle arrest in HUVECs. Besides, OSU-A9 inhibited angiogenesis as evidenced by abrogation of migration/invasion and Matrigel tube formation in HUVECs and attenuation of the in vivo neovascularization in the chicken chorioallantoic membrane assay. Mechanistically, Western blot, RT-PCR and ELISA analyses showed the ability of OSU-A9 to inhibit MMP-2 production and VEGF expression induced by hypoxia or phorbol-12-myristyl-13-acetate. Furthermore, dual inhibition of Akt–NF-?B and mitogen-activated protein kinase (MAPK) signaling, the key regulators of angiogenesis, was observed. Together, the current study highlights evidences for the promising anti-angiogenic activity of OSU-A9, at least in part through the inhibition of Akt–NF-?B and MAPK signaling and their consequent inhibition of VEGF and MMP-2. These findings support OSU-A9's clinical promise as a component of anticancer therapy. - Highlights: • The antiangiogenic activity of OSU-A9 in HUVECs was explored. • OSU-A9 inhibited HUVECs proliferation, migration, invasion and tube formation. • OSU-A9 targeted signaling pathways mediated by Akt-NF-kB, VEGF, and MMP-2. • The anti-angiogenic activity of OSU-A9 supports its clinical promise.

  19. NF_Eder_2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Saleshttp://www.fnal.gov/directorate/nalcal/nalcal02_07_05_files/nalcal.gif Directorate1, Issue 23 NETL NEVIS- 97NEWS RELEASE For3

  20. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-{kappa}B activation and the JAK/STAT pathway

    SciTech Connect (OSTI)

    Lv, Na; Kim, Eun-Kyung; Song, Mi-Young [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of); Choi, Ha-Na; Moon, Woo Sung [Department of Pathology, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Pathology, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of); Park, Sung-Joo [Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749 (Korea, Republic of)] [Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749 (Korea, Republic of); Park, Jin-Woo [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of); Kwon, Kang-Beom, E-mail: desson@wonkwang.ac.kr [Department of Physiology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749 (Korea, Republic of)] [Department of Physiology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749 (Korea, Republic of); Park, Byung-Hyun, E-mail: bhpark@chonbuk.ac.kr [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)

    2009-07-15T23:59:59.000Z

    JANEX-1/WHI-P131, a selective Janus kinase 3 (JAK3) inhibitor, has been shown to delay the onset of diabetes in the NOD mouse model. However, the molecular mechanism by which JANEX-1 protects pancreatic {beta}-cells is unknown. In the current study, we investigated the role of JANEX-1 on interleukin (IL)-1{beta} and interferon (IFN)-{gamma}-induced {beta}-cell damage using isolated islets. JANEX-1-pretreated islets showed resistance to cytokine toxicity, namely suppressed nitric oxide (NO) production, reduced inducible form of NO synthase (iNOS) expression, and decreased islet destruction. The molecular mechanism by which JANEX-1 inhibits iNOS expression was mediated through suppression of the nuclear factor {kappa}B (NF-{kappa}B) and JAK/signal transducer and activator of transcription (STAT) pathways. Islets treated with the cytokines downregulated the protein levels of suppressor of cytokine signaling (SOCS)-1 and SOCS-3, but pretreatment with JANEX-1 attenuated these decreases. Additionally, islets from JAK3{sup -/-} mice were more resistant to cytokine toxicity than islets from control mice. These results demonstrate that JANEX-1 protects {beta}-cells from cytokine toxicity through suppression of the NF-{kappa}B and JAK/STAT pathways and upregulation of SOCS proteins, suggesting that JANEX-1 may be used to preserve functional {beta}-cell mass.

  1. Early induction of cytokines/cytokine receptors and Cox2, and activation of NF-?B in 4-nitroquinoline 1-oxide-induced murine oral cancer model

    SciTech Connect (OSTI)

    Liu, Yu-Ching [Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan (China) [Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan (China); Department of Veterinary Medicine, National Chung Hsing University, Taichung 402, Taiwan (China); Ho, Heng-Chien; Lee, Miau-Rong [Department of Biochemistry, China Medical University, Taichung 404, Taiwan (China)] [Department of Biochemistry, China Medical University, Taichung 404, Taiwan (China); Lai, Kuang-Chi [Department of Surgery, China Medical University Beigang Hospital, Yunlin 651, Taiwan (China) [Department of Surgery, China Medical University Beigang Hospital, Yunlin 651, Taiwan (China); School of Medicine, China Medical University, Taichung 404, Taiwan (China); Yeh, Chung-Min; Lin, Yueh-Min [Department of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan (China)] [Department of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan (China); Ho, Tin-Yun [School of Chinese Medicine, China Medical University, Taichung 404, Taiwan (China)] [School of Chinese Medicine, China Medical University, Taichung 404, Taiwan (China); Hsiang, Chien-Yun, E-mail: cyhsiang@mail.cmu.edu.tw [Department of Microbiology, China Medical University, Taichung 404, Taiwan (China)] [Department of Microbiology, China Medical University, Taichung 404, Taiwan (China); Chung, Jing-Gung, E-mail: jgchung@mail.cmu.edu.tw [Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan (China) [Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan (China); Department of Biotechnology, Asia University, Taichung 413, Taiwan (China)

    2012-07-15T23:59:59.000Z

    The purpose of this study was to identify the genes induced early in murine oral carcinogenesis. Murine tongue tumors induced by the carcinogen, 4-nitroquinoline 1-oxide (4-NQO), and paired non-tumor tissues were subjected to microarray analysis. Hierarchical clustering of upregulated genes in the tumor tissues revealed an association of induced genes with inflammation. Cytokines/cytokine receptors induced early were subsequently identified, clearly indicating their involvement in oral carcinogenesis. Hierarchical clustering also showed that cytokine-mediated inflammation was possibly linked with Mapk6. Cox2 exhibited the greatest extent (9–18 fold) of induction in the microarray data, and its early induction was observed in a 2 h painting experiment by RT-PCR. MetaCore analysis showed that overexpressed Cox2 may interact with p53 and transcriptionally inhibit expression of several downstream genes. A painting experiment in transgenic mice also demonstrated that NF-?B activates early independently of Cox2 induction. MetaCore analysis revealed the most striking metabolic alterations in tumor tissues, especially in lipid metabolism resulting from the reduction of Ppar? and Rxrg. Reduced expression of Mapk12 was noted, and MetaCore analysis established its relationship with decreased efficiency of Ppar? phosphorylation. In conclusion, in addition to cytokines/cytokine receptors, the early induction of Cox2 and NF-?B activation is involved in murine oral carcinogenesis.

  2. High-loop perturbative renormalization constants for Lattice QCD (III): three-loop quark currents for Iwasaki gauge action and n_f=4 Wilson fermions

    E-Print Network [OSTI]

    M. Brambilla; F. Di Renzo; M. Hasegawa

    2014-06-23T23:59:59.000Z

    This is the third of a series of papers on three-loop computation of renormalization constants for Lattice QCD. Our main point of interest are results for the regularization defined by Iwasaki gauge action and n_f=4 Wilson fermions. Our results for quark bilinears renormalized according to the RI'-MOM scheme can be compared to non-perturbative results. The latter are available for Twisted Mass QCD: being defined in the chiral limit, renormalization constants must be the same. We also address more general problems. In particular, we discuss a few methodological issues connected to summing the perturbative series such as the effectiveness of Boosted Perturbation Theory and the disentanglement of irrelevant and finite volume contributions. Discussing these issues we consider ont only the new results of this paper, but also those for the regularization defined by tree-level Symanzik improved gauge action and n_f=2 Wilson fermions, which we presented in a recent paper of ours. We finally comment to which extent the techniques we put at work in the NSPT context can provide a fresher look into the lattice version of the RI'-MOM scheme.

  3. A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-?B and Nrf2-Keap1 signaling pathways

    SciTech Connect (OSTI)

    Gan, Fei-Fei; Ling, Hui; Ang, Xiaohui; Reddy, Shridhivya A.; Lee, Stephanie S-H.; Yang, Hong; Tan, Sock-Hoon [Department of Pharmacy, Faculty of Science, National University of Singapore (Singapore); Hayes, John D. [Jacqui Wood Cancer Centre, Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland (United Kingdom); Chui, Wai-Keung [Department of Pharmacy, Faculty of Science, National University of Singapore (Singapore); Chew, Eng-Hui, E-mail: phaceh@nus.edu.sg [Department of Pharmacy, Faculty of Science, National University of Singapore (Singapore)

    2013-11-01T23:59:59.000Z

    Natural compounds containing vanilloid and Michael acceptor moieties appear to possess anti-cancer and chemopreventive properties. The ginger constituent shogaol represents one such compound. In this study, the anti-cancer potential of a synthetic novel shogaol analog 3-phenyl-3-shogaol (3-Ph-3-SG) was assessed by evaluating its effects on signaling pathways. At non-toxic concentrations, 3-Ph-3-SG suppressed cancer cell invasion in MDA-MB-231 and MCF-7 breast carcinoma cells through inhibition of PMA-activated MMP-9 expression. At similar concentrations, 3-Ph-3-SG reduced expression of the inflammatory mediators nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and prostanglandin-E{sub 2} (PGE{sub 2}) in RAW 264.7 macrophage-like cells. Inhibition of cancer cell invasion and inflammation by 3-Ph-3-SG were mediated through suppression of the nuclear factor-kappaB (NF-?B) signaling pathway. The 3-Ph-3-SG also demonstrated cytoprotective effects by inducing the antioxidant response element (ARE)-driven genes NAD(P)H quinone oxidoreductase-1 (NQO1) and heme oxygenase-1 (HO-1). Cytoprotection by 3-Ph-3-SG was achieved at least partly through modification of cysteine residues in the E3 ubiquitin ligase substrate adaptor Kelch-like ECH-associated protein 1 (Keap1), which resulted in accumulation of transcription factor NF-E2 p45-related factor 2 (Nrf2). The activities of 3-Ph-3-SG were comparable to those of 6-shogaol, the most abundant naturally-occurring shogaol, and stronger than those of 4-hydroxyl-null deshydroxy-3-phenyl-3-shogaol, which attested the importance of the 4-hydroxy substituent in the vanilloid moiety for bioactivity. In summary, 3-Ph-3-SG is shown to possess activities that modulate stress-associated pathways relevant to multiple steps in carcinogenesis. Therefore, it warrants further investigation of this compound as a promising candidate for use in chemotherapeutic and chemopreventive strategies. - Highlights: • Novel shogaol 3-phenyl-3-shogaol suppressed cancer cell invasion and inflammation. • Anti-invasive and anti-inflammatory effects were NF-?B-dependent. • 3-Phenyl-3-shogaol induced ARE-driven genes to achieve cytoprotection. • Cytoprotective effects were brought about by modification of cysteines in Keap1. • Chemopreventive activities of 3-phenyl-3-shogaol and 6-shogaol were comparable.

  4. Microtrenching-free two-step reactive ion etching of 4H-SiC using NF{sub 3}/HBr/O{sub 2} and Cl{sub 2}/O{sub 2}

    SciTech Connect (OSTI)

    Tseng, Yuan-Hung, E-mail: yhtseng.ee99g@nctu.edu.tw; Tsui, Bing-Yue [Department of Electronics Engineering, National Chiao Tung University, No. 1001, Daxue Rd., East Dist., Hsinchu City 30010, Taiwan (China)

    2014-05-15T23:59:59.000Z

    In this paper, the authors performed a reactive ion etch of a 4H-SiC substrate with a gas mixture of NF{sub 3}, HBr, and O{sub 2}, resulting in a microtrenching-free etch. The etch rate was 107.8?nm/min, and the selectivity over the oxide hard mask was ?3.85. Cross-sectional scanning electron microscopy showed no microtrenching compared with etches using plasmas of NF{sub 3}, NF{sub 3}/HBr, and NF{sub 3}/O{sub 2}. Analyzing a variety of HBr/O{sub 2} mixing ratios, the authors discuss the additive effect of each gas and their respective potential mechanisms for alleviating microtrenching. To increase the radius of gyration of the bottom corners, they introduced a second etch step with Cl{sub 2}/O{sub 2} plasma. Fabricating simple metal-oxide-semiconductor capacitors on the two-step etched surface, the authors found that the electrical characteristics of the etched sample were nearly the same as the nonetched sample.

  5. Relation between two-point Green functions of ${\\cal N}=1$ SQED with $N_f$ flavors, regularized by higher derivatives, in the three-loop approximation

    E-Print Network [OSTI]

    A. E. Kazantsev; K. V. Stepanyantz

    2014-10-05T23:59:59.000Z

    We verify the identity which relates the two-point Green functions of ${\\cal N}=1$ SQED with $N_f$ flavors, regularized by higher derivatives, by explicit calculations in the three-loop approximation. This identity explains why in the limit of the vanishing external momentum the two-point Green function of the gauge superfield is given by integrals of double total derivatives in the momentum space. It also allows to derive the NSVZ $\\beta$-function exactly in all loops if the renormalization group functions are defined in terms of the bare coupling constant. In order to verify the considered identity we use it for constructing integrals giving the three-loop $\\beta$-function starting from the two-point Green functions of the matter superfields in the two-loop approximation. Then we demonstrate that the results for these integrals coincide with the sums of the corresponding three-loop supergraphs.

  6. 4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-{kappa}B and ERK/MAPK

    SciTech Connect (OSTI)

    Chen Zhihua [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Na, Hye-Kyung [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Hurh, Yeon-Jin [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Surh, Young-Joon [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of)]. E-mail: surh@plaza.snu.ac.kr

    2005-10-01T23:59:59.000Z

    Catechol estrogens, the hydroxylated metabolites of 17{beta}-estradiol (E{sub 2}), have been considered to be implicated in estrogen-induced carcinogenesis. 4-Hydroxyestradiol (4-OHE{sub 2}), an oxidized metabolite of E{sub 2} formed preferentially by cytochrome P450 1B1, reacts with DNA to form depurinating adducts thereby exerting genotoxicity and carcinogenicity. 4-OHE{sub 2} undergoes 2-electron oxidation to quinone via semiquinone, and during this process, reactive oxygen species (ROS) can be generated to cause DNA damage and cell death. In the present study, 4-OHE{sub 2} was found to elicit cytotoxicity in cultured human mammary epithelial (MCF-10A) cells, which was blocked by the antioxidant trolox. MCF-10A cells treated with 4-OHE{sub 2} exhibited increased intracellular ROS accumulation and 8-oxo-7,8-dihydroxy-2'-deoxyguanosine formation, and underwent apoptosis as determined by poly(ADP-ribose)polymerase cleavage and disruption of mitochondrial transmembrane potential. The redox-sensitive transcription factor nuclear factor {kappa}B (NF-{kappa}B) was transiently activated by 4-OHE{sub 2} treatment. Cotreatment of MCF-10A cells with the NF-{kappa}B inhibitor, L-1-tosylamido-2-phenylethyl chloromethyl ketone, exacerbated 4-OHE{sub 2}-induced cell death. 4-OHE{sub 2} also caused transient activation of extracellular signal-regulated protein kinases (ERK) involved in transmitting cell survival or death signals. A pharmacological inhibitor of ERK aggravated the 4-OHE{sub 2}-induced cytotoxicity, supporting the pivotal role of ERK in protecting against catechol estrogen-induced oxidative cell death.

  7. 2030 Metropolitan Transportation Plan for the Albuquerque Metropolitan Planning Area

    E-Print Network [OSTI]

    Mid-Region Metropolitan Planning Organization

    2007-04-26T23:59:59.000Z

    ...................................................................13-13 #0;#1;#0;#1; #0;5#0;"#0;##0;-#0;4#0;#1; 2-1 Population Density by Municipality, 2000-2004 ..........................................................................................2-2 2-2 Population by Municipality, 2000-2004..........................................................................................................2-3... .....................................................................................14-2 14-2 Neighborhood Association and Community Group MTP Meetings....................................................14-3 #0;#1; #0;'#0;*#0;(#0;6#0;3#0;4#0;#1; 2-1 Residential Building Permits, 1990...

  8. Abilene Metropolitan Area Metropolitan Transportation Plan 2010-2035

    E-Print Network [OSTI]

    Abilene Metropolitan Planning Organization

    2010-01-12T23:59:59.000Z

    City City of Abilene, Texas Class. Classification Col. Collector E. East Equip. Equipment FAA Federal Aviation Administration FHWA Federal Highway Administration FTA Federal Transit Administration FR or fr Frontage Road FM..., Texas Jones County Taylor County Texas Department of Transportation United States Department of Transportation Federal Highway Administration Federal Transit Administration Adopted by Policy Board January 12, 2010 Table...

  9. 2030 Metropolitan Transportation Plan for the Albuquerque Metropolitan Planning Area 

    E-Print Network [OSTI]

    Mid-Region Metropolitan Planning Organization

    2007-04-26T23:59:59.000Z

    ;B#0;O#0;#1;#0;5#0;S#0;B#0;O#0;T#0;Q#0;P#0;S#0;U#0;B#0;U#0;J#0;P#0;O#0;#1;#0;1#0;M#0;B#0;O#0;#1;#0; #0;.#0;5#0;1#0; #0;#1; #0;G#0;P#0;S#0;#1;#0;U#0;I#0;F#0;#1;#0;"#0;M#0;C#0;V#0;R#0;V#0;F#0;S#0;R#0;V#0;F#0;#1;#0;.#0;F#0;U#0;S#0;P#0;Q#0;P#0;M#0;J#0;U#0...#0;#19;#0;#17;#0;#20;#0;#17;#0;#1;#0;.#0;F#0;U#0;S#0;P#0;Q#0;P#0;M#0;J#0;U#0;B#0;O#0;#1;#0;5#0;S#0;B#0;O#0;T#0;Q#0;P#0;S#0;U#0;B#0;U#0;J#0;P#0;O#0;#1;#0;1#0;M#0;B#0;O#0;#1;#0; #0;.#0;5#0;1#0; #0;#1; #0;G#0;P#0;S#0;#1;#0;U#0;I#0;F#0;#1;#0;"#0;M#0;C#0...

  10. MANCHESTER METROPOLITAN DISABILITY EQUALITY SCHEME

    E-Print Network [OSTI]

    assessment following the creation of a dedicated Equalities Impact Assessment (EIA) team. In order to keep up has been made a priority for the Equalities and EIA teams by the Development & Training Manager

  11. MANCHESTER METROPOLITAN UNIVERSITY POLICY FRAMEWORK

    E-Print Network [OSTI]

    AND ACADEMIC SERVICES GOVERNANCE AND SECRETARIAT TEAM POLICY FRAMEWORK AND EQUALITY IMPACT ASSESSMENT (EIA date, date EIA approved, approval body and review date. Other points to consider include: Additional

  12. Mobility 2035 Metropolitan Transportation Plan

    E-Print Network [OSTI]

    Killeen-Temple Urban Transportation Study

    2009-05-20T23:59:59.000Z

    totality to include the ecological, physical (natural and manmade), social, political, aesthetic, and economic environments.? The Federal Highway Administration (FHWA) defines three basic principles of environmental justice: ? Avoid, minimize... ............................................................................................................... 2 Creation of Mobility 2035 and Who is Involved ...................................................................................... 2 Federal and State Requirements...

  13. Prepared for: New York Metropolitan

    E-Print Network [OSTI]

    Qiu, Weigang

    .............................................................................................................................2-2 Power................................................................................................................................2-2 Purchase Recommendations

  14. a sustainable Manchester Metropolitan University

    E-Print Network [OSTI]

    Management Plan which has been used as an exemplar of best practice across the public sector by the Carbon of student demand and consequent financial sustainability. Despite this, MMU remains in a strong position commitment to environmental responsibility; we remain determined to lead the sector in attaining

  15. Metropolitan Landfill Abatement Act (Minnesota)

    Broader source: Energy.gov [DOE]

    A fee is imposed on operators of mixed municipal solid waste disposal facilities corresponding to the amount of waste taken in. Waste residue from recycling facilities or resource recovery...

  16. Manchester Metropolitan University Travel Plan

    E-Print Network [OSTI]

    by providing more assistance to staff who are considering sharing car journeys, switching to public transport with the introduction of schemes to facilitate car sharing and the purchase of discounted season tickets on public.2 Measures to Reduce Car Use...............................................................................9

  17. San Angelo Metropolitan Transportation Plan

    E-Print Network [OSTI]

    San Angelo Metropolitan Planning Organization

    2009-11-16T23:59:59.000Z

    : City of San Angelo Tom Green County Concho Valley Transit District Texas Department of Transportation U.S. Department of Transportation Federal Highway Administration Federal Transit Administration Approved... Director Concho Valley Council of Governments * Elected Non-Voting Members Drew Darby* State Representative, State of Texas Robert Duncan* State Senator, State of Texas Peggy Thurin Statewide Planning Coordinator...

  18. Nature of Roberge-Weiss transition end points for heavy quarks in $N_f=2$ lattice QCD with Wilson fermions

    E-Print Network [OSTI]

    Liang-Kai Wu; Xiang-Fei Meng

    2014-10-26T23:59:59.000Z

    The phase structure of QCD with imaginary chemical potential provides information on the phase diagram of QCD with real chemical potential. With imaginary chemical potential $i\\mu_I=i\\pi T$, previous studies show that the Roberge-Weiss (RW) transition end points are triple points at both large and small quark masses, and second order transition points at intermediate quark masses. The triple and second order end points are separated by two tricritical ones. We present simulations with $ N_f=2 $ Wilson fermions to investigate the nature of RW transition end points. The simulations are carried out at 8 values of the hopping parameter $\\kappa$ ranging from 0.020 to 0.140 on different lattice volumes. The Binder cumulant, susceptibility and reweighted distribution of the imaginary part of Polyakov loop are employed to determine the nature of RW transition end points. The simulations show that the two tricritical points are within the range $0.070-0.080$ and $0.120-0.140$, respectively.

  19. Measurement of the F2n/F2p and d/u Ratios in Deep Inelastic Electron Scattering off 3H and 3He

    E-Print Network [OSTI]

    G. G. Petratos; I. R. Afnan; F. Bissey; J. Gomez; A. T. Katramatou; W. Melnitchouk; A. W. Thomas

    2000-10-19T23:59:59.000Z

    We discuss a possible measurement of the ratio of the nucleon structure functions, F2n/F2p, and the ratio of the up to down quark distributions, u/d, at large x, by performing deep inelastic electron scattering from the 3H and 3He mirror nuclei with the 11 GeV upgraded beam of Jefferson Lab. The measurement is expected to be almost free of nuclear effects, which introduce a significant uncertainty in the extraction of these two ratios from deep inelastic scattering off the proton and deuteron. The results are expected to test perturbative and non-perturbative mechanisms of spin-flavor symmetry breaking in the nucleon, and constrain the structure function parameterizations needed for the interpretation of high energy e-p, p-p and p-pbar collider data. The precision of the expected data can also allow for testing competing parameterizations of the nuclear EMC effect and provide valuable constraints on models of its dynamical origin.

  20. Lattice NRQCD study of S- and P-wave bottomonium states in a thermal medium with $N_f=2+1$ light flavors

    E-Print Network [OSTI]

    Seyong Kim; Peter Petreczky; Alexander Rothkopf

    2014-09-12T23:59:59.000Z

    We investigate the properties of S-and P-wave bottomonium states in the vicinity of the deconfinement transition temperature. The light degrees of freedom are represented by dynamical lattice QCD configurations of the HotQCD collaboration with $N_f = 2 + 1$ flavors. Bottomonium correlators are obtained from bottom quark propagators, computed in Non-Relativistic QCD (NRQCD) under the background of these gauge field configurations. The spectral functions for the $^3S_1$ ($\\Upsilon$) and $^3P_1$ ($\\chi_{b1}$) channel are extracted from the Euclidean time correlators using a novel Bayesian approach in the temperature region $140 {\\rm MeV} \\le T \\le 249 {\\rm MeV}$ and the results are contrasted to those from the standard Maximum Entropy Method. We find that the new Bayesian approach is far superior to the Maximum Entropy Method and enables us to study reliably the first peak in the spectral functions even under the limitations present in the finite temperature setup. We find that $\\chi_{b1}$ survives up to $T=249 {\\rm MeV}$, the highest temperature considered in our study and put stringent constraints on the size of the medium modification of $\\Upsilon$ and $\\chi_{b1}$ states.

  1. Leptonic decay constants fK, fD and fDs with Nf = 2+1+1 twisted-mass lattice QCD

    E-Print Network [OSTI]

    N. Carrasco; P. Dimopoulos; R. Frezzotti; P. Lami; V. Lubicz; F. Nazzaro; E. Picca; L. Riggio; G. C. Rossi; F. Sanfilippo; S. Simula; C. Tarantino

    2015-02-25T23:59:59.000Z

    We present a lattice QCD calculation of the pseudoscalar decay constants fK, fD and fDs performed using the gauge configurations produced by the European Twisted Mass Collaboration with Nf = 2 + 1 + 1 dynamical quarks, which include in the sea, besides two light mass degenerate quarks, also the strange and charm quarks with masses close to their values in the real world. The simulations are based on a unitary setup for the two light mass-degenerate quarks and on a mixed action approach for the strange and charm quarks. We use data simulated at three different values of the lattice spacing in the range 0.06 - 0.09 fm and at pion masses in the range 210 - 450 MeV. Our main results are: fK+ / fpi+ = 1.184 (16), fK+ = 154.4 (2.0) MeV, which incorporate the leading strong isospin breaking correction due to the up- and down-quark mass difference, and fK = 155.0 (1.9) MeV, fD = 207.4 (3.8) MeV, fDs = 247.2 (4.1) MeV, fDs / fD = 1.192 (22) and (fDs / fD) / (fK / fpi) = 1.003 (14) obtained in the isospin symmetric limit of QCD. Combined with the experimental measurements of the leptonic decay rates of kaon, pion, D- and Ds-mesons our results lead to the following determination of the CKM matrix elements: |Vus| = 0.2269 (29), |Vcd| = 0.2221 (67) and |Vcs| = 1.014 (24). Using the latest value of |Vud| from superallowed nuclear beta decays the unitarity of the first row of the CKM matrix is fulfilled at the permille level.

  2. The REMOTE SENSlNf

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA group currentBradleyTableSelling7 AugustAFRICAN3uj: ;;IDEC. i' , i Department_''1

  3. Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-{kappa}B translocation

    SciTech Connect (OSTI)

    Jawan, Bruno [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Kao, Y.-H. [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Department of Biological Sciences, National Sun Yat-Sen University, 70 Lien-Hai Road, Kaohsiung 804, Taiwan (China); Goto, Shigeru [Department of Surgery and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Department of Surgery, Iwao Hospital, 3059-1 Kawakami, Yufuin, Oita 879-5102 (Japan); Pan, M.-C. [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Lin, Y.-C.; Hsu, L.-W.; Nakano, Toshiaki; Lai, C.-Y.; Sun, C.-K.; Cheng, Y.-F. [Department of Surgery and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Tai, M.-H. [Department of Biological Sciences, National Sun Yat-Sen University, 70 Lien-Hai Road, Kaohsiung 804, Taiwan (China); Department of Medical Research and Education, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Road, Kaohsiung 813, Taiwan (China)] (and others)

    2008-06-15T23:59:59.000Z

    Propofol (PPF), a widely used intravenous anesthetic for induction and maintenance of anesthesia during surgeries, was found to possess suppressive effect on host immunity. This study aimed at investigating whether PPF plays a modulatory role in the lipopolysaccharide (LPS)-induced inflammatory cytokine expression in a cell line of rat hepatocytes. Morphological observation and viability assay showed that PPF exhibits no cytotoxicity at concentrations up to 300 {mu}M after 48 h incubation. Pretreatment with 100 {mu}M PPF for 24 h prior to LPS stimulation was performed to investigate the modulatory effect on LPS-induced inflammatory gene production. The results of semi-quantitative RT-PCR demonstrated that PPF pretreatment significantly suppressed the LPS-induced toll-like receptor (TLR)-4, CD14, tumor necrosis factor (TNF)-{alpha}, and granulocyte-macrophage colony-stimulating factor (GM-CSF) gene expression. Western blotting analysis showed that PPF pretreatment potentiated the LPS-induced TLR-4 downregulation. Flow cytometrical analysis revealed that PPF pretreatment showed no modulatory effect on the LPS-upregulated CD14 expression on hepatocytes. In addition, PPF pretreatment attenuated the phosphorylation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and I{kappa}B{alpha}, as well as the nuclear translocation of NF-{kappa}B primed by LPS. Moreover, addition of PD98059, a MAPK kinase inhibitor, significantly suppressed the LPS-induced NF-{kappa}B nuclear translocation and GM-CSF production, suggesting that the PPF-attenuated GM-CSF production in hepatocytes may be attributed to its suppressive effect on MAPK/ERK signaling pathway. In conclusion, PPF as an anesthetic may clinically benefit those patients who are vulnerable to sepsis by alleviating sepsis-related inflammatory response in livers.

  4. D-Saccharic acid 1,4-lactone protects diabetic rat kidney by ameliorating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via NF-?B and PKC signaling

    SciTech Connect (OSTI)

    Bhattacharya, Semantee [Department of Life Sciences and Biotechnology, Jadavpur University, 188, Raja S C Mullick Road, Kolkata 700 032 (India); Manna, Prasenjit [Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata-700054 (India); Gachhui, Ratan [Department of Life Sciences and Biotechnology, Jadavpur University, 188, Raja S C Mullick Road, Kolkata 700 032 (India); Sil, Parames C., E-mail: parames@bosemain.boseinst.ac.in [Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata-700054 (India)

    2013-02-15T23:59:59.000Z

    Increasing evidence suggests that oxidative stress is involved in the pathogenesis of diabetic nephropathy (DN) and this can be attenuated by antioxidants. D-Saccharic acid 1,4-lactone (DSL) is known for its detoxifying and antioxidant properties. Our early investigation showed that DSL can ameliorate alloxan (ALX) induced diabetes mellitus and oxidative stress in rats by inhibiting pancreatic ?-cell apoptosis. In the present study we, therefore, investigated the protective role of DSL against renal injury in ALX induced diabetic rats. ALX exposure (at a dose of 120 mg/kg body weight, i. p., once) elevated the blood glucose level, serum markers related to renal injury, the production of reactive oxygen species (ROS), and disturbed the intra-cellular antioxidant machineries. Oral administration of DSL (80 mg/kg body weight) restored all these alterations close to normal. In addition, DSL could also normalize the aldose reductase activity which was found to increase in the diabetic rats. Investigating the mechanism of its protective activity, we observed the activation of different isoforms of PKC along with the accumulation of matrix proteins like collagen and fibronectin. The diabetic rats also showed nuclear translocation of NF-?B and increase in the concentration of inflammatory cytokines in the renal tissue. The activation of mitochondria dependent apoptotic pathway was observed in the diabetic rat kidneys. However, treatment of diabetic rats with DSL counteracted all these changes. These findings, for the first time, demonstrated that DSL could ameliorate renal dysfunction in diabetic rats by suppressing the oxidative stress related signalling pathways. - Highlights: ? Sustained hyperglycemia and oxidative stress lead to diabetic renal injury. ? D-saccharic acid 1,4-lactone prevents renal damage in alloxan-induced diabetes. ? It restores intra-cellular antioxidant machineries and kidney apoptosis. ? DSL reduces hyperglycemia-mediated oxidative stress via NF-kB and PKC signaling. ? DSL may act as a beneficial agent in hyperglycemia induced renal disorder.

  5. Transportation 2035 Longview Metropolitan Transportation Plan

    E-Print Network [OSTI]

    Longview Metropolitan Planning Organization

    2009-11-12T23:59:59.000Z

    Owen, MPO Director Melissa Bechtold, Transportation Planner Nalora Moser, Planning Technician MPO TECHNICAL COMMITTEE Karen Owen, City of Longview Fred Marquez, TXDOT-Austin Dale Spitz, TXDOT-Tyler District Debbie Sadler, City of White... Oak Will Buskell, TXDOT-Longview Area Rea Donna Jones, TXDOT-Atlanta District Margie McAllister, TCEQ-Austin Randy Redmond, TXDOT-Tyler District John Paul Jones, Harrison County Keith Bonds, City of Longview Steve Juneau, TXDOT-Marshall...

  6. 2010-2035 Metropolitan Transportation Plan

    E-Print Network [OSTI]

    Bryan/College Station Metropolitan Planning Organization

    2009-12-02T23:59:59.000Z

    Bryan-College Station Airports Fish Tan k Har vey Mi tche ll Dis pos al P lan t Lut her Wh ite Cre ek Ray mon d St otze r Dow ling Favor PE NB ER TH Y BL We lco me Sti llw ate r Tu rke y C ree k George Bu sh JO HN K IM BR OU GH B L Wh ispe... Vi ew Wh ite s C ree k Easterwood Airport Easterwood Airport 0 .1 .2 .3 Miles 09/24/09 Legend Bryan City Limits College Station LAKES Water Features Streets Buildings Airports Selection Ea st S H 2 1 Ma rino Wa llac e Cro ssw ind Ea st Wa llis Coulter...

  7. MANCHESTER METROPOLITAN UNIVERSITY ORGANISATION DEVELOPMENT & TRAINING

    E-Print Network [OSTI]

    the Equality & Diversity (E&D) and the Equality Impact Assessment (EIA) Teams are jointly running a Student Research with Disabled Students on Library & ICT Services Through EIA activity in the areas of Library in both of these departments were screened ­ with the EIA Team and policy owners ­ to assess the potential

  8. Las Cruces MPO 2040 Metropolitan Transportation Plan

    E-Print Network [OSTI]

    Las Cruces Metropolitan Planning Organization

    2010-06-09T23:59:59.000Z

    : Tim Sanders, Bureau of Land Management, and Paul Howard, Do?a Ana County Planning. Finally, MPO staff would like to thank various members of the community and government staff for providing noteworthy assistance to us during our public input... A BALANCE 89 i TRANSPORT 2040 THE IMPLEMENTATION STRATEGIES CHAPTER 4 STRATEGY TOOLBOXES 91 INTRODUCTION 91 LAND USE AND DESIGN ELEMENTS 92 GREEN OPPORTUNITIES 99 MANAGEMENT PLANS 101 RESOURCE AND OUTREACH CENTER 107 PROCESS DEVELOPMENT...

  9. Ryan Groom & Simon Wilson Manchester Metropolitan University

    E-Print Network [OSTI]

    's largest companies: AT&T, Ford, IBM, Apple, Chrysler, Coca- Cola, Hewlett-Packard, The New York Times

  10. Lafayette Metropolitan Planning Organization 2030 Transportation Plan

    E-Print Network [OSTI]

    Lafayette Metropolitan Planning Organization

    2010-10-31T23:59:59.000Z

    of Carencro Byron Breaux City-Parish Council Designee John Broussard City-Parish President Designee Vernal Comeaux City-Parish Council Designee Bill Fontenot La Dept of Transportation and Development Lucien Gastineau City-Parish Planning Commission...

  11. Laredo 2010-2035 Metropolitan Transportation Plan

    E-Print Network [OSTI]

    Laredo Urban Transportation Study

    2009-12-11T23:59:59.000Z

    ?Rivera,?PE? Linda?Vela The?preparation?and?publication?of?this?report?was?financed?in?part?through?grants?from?the? Federal?Highway?Administration,?the?Federal?Transit?Administration,?and?the?Texas? Department?of?Transportation....?All?opinions,?findings,?and?conclusions?presented?in?this?report? reflect?the?view?of?the?Plan?authors?and?do?not?necessarily?reflect?the?official?views?or?policy? of?the?Federal?Highway?Administration,?the?Federal?Transit?Administration,?or?the?Texas? Department?of?Transportation.? ? ? ? ? ? ? ? ? ? ? THIS...

  12. Climate Action Champions: Metropolitan Washington Council of...

    Office of Environmental Management (EM)

    evaluates mitigation and adaptation strategies, and establishes greenhouse gas emission reduction goals of 20 percent by 2020, and 80 percent by 2050 as compared to a 2005...

  13. 2010-2035 Metropolitan Transportation Plan 

    E-Print Network [OSTI]

    Hidalgo County Metropolitan Planning Organization

    2009-12-10T23:59:59.000Z

    !"#"$%$!"&'$()*+,-,./*01$2+013-,+*0*/,1$4.01$ !"#$$%&'( #)( *+&,$( ! ! ! ! ! ! ! ! "##$%&'(!"! )*+,! C O U N T Y L I N E R D E UBA NKS R D W A L L A C E R D F M 2 2 2 1 S E M I N A R Y R D... F M 5 0 6 I O W A F M 4 9 0 S T A T E H W Y 1 0 7 F M 1 4 2 2 B I G 5 F M 4 9 1 D O O L I T T L E F M 6 8 1 J A R A C H I N A S R D F M 4 9 3 B R U S H L I N E F M 1 4 2 5 M I L E MI L I T A R Y H W Y F M 8 8 I N T E R N A T I...

  14. Metropolitan Transportation Plan 2005-2030 

    E-Print Network [OSTI]

    Santa Fe Metropolitan Planning Organization

    1999-01-01T23:59:59.000Z

    are being impacted. The ?sub areas? include: Airport Road, NM 599, Richards Avenue/Rodeo Road and South St. Francis Drive. 6 The fifth meeting was a demonstration of the traffic modeling software (VISUM) presented by Robert Shull of PTV America. VISUM... be completed as well as the connection between Agua Fria Rd and County Road 62 at NM 599. ? Traffic calming measures are recommended for Lopez Lane. Public Comment Summary: South St. Francis Drive The comments on this topic were primarily about how to improve...

  15. 2010-2035 Metropolitan Transportation Plan

    E-Print Network [OSTI]

    Hidalgo County Metropolitan Planning Organization

    2009-12-10T23:59:59.000Z

    O N A L B L V D / S P U R 1 1 5 B R U S H L I N E R D C O U N T Y L I N E S T A T E H W Y 1 8 6 U n k n o w n F M 2 6 2 9 M I L E 5 R D W M IL IT A R Y F M 1 0 1 5 M I N N E S O T A L A H O M A V A L L E Y V I E W R D R I O... G R A N D E C A R E C H I H U A H U A R D L A K E S H O R E D R S B E N T S O N S T O W E R R D M I L E 4 R D W M I L E 2 R D W M I L E 6 I O W A A V E R A N C H O T O L U C A R D D O F F I N G R D U S 2 8 1 T E X AS V...

  16. Las Cruces MPO 2040 Metropolitan Transportation Plan 

    E-Print Network [OSTI]

    Las Cruces Metropolitan Planning Organization

    2010-06-09T23:59:59.000Z

    circumstance, wes not determined, LITERAT %E CITS' Esm, Katherine, Plant Anatosy, John k'iley and Sons& p 115~ 1953. 2. Johansen~ D. A. , Plsnt Eicrotechnique~ HcOx'aw Hill~ p 87 ~ 19h0. 'Oosssrd, A. C?Rooting of pecan stea tissue by layering~ Aaerioan..., Page 24 TJL'ELK XQ Nuaher of roots per tree in 'Ireataents 1 and 2 on the two dates of inspections Ju+ la 1957~ and Narch 9a 1958 Date of Inspection ". reataent 1 Treataent 2 July la 1957 10 Naroh 9a 1958 Averais 2d 12 ho m ...

  17. MANCHESTER METROPOLITAN UNIVERSITY ORGANISATION DEVELOPMENT & TRAINING

    E-Print Network [OSTI]

    Throughout the 2008/9 academic year the Equality & Diversity (E&D) and the Equality Impact Assessment (EIA carried out during the autumn term. It is anticipated that it will be used to support EIA activity within the development of the University's Single Equality Scheme. Appendix 1 contains the Bristol Online Survey (BOS

  18. 2010 - 2035 Brownsville Metropolitan Transportation Plan

    E-Print Network [OSTI]

    Brownsville Metropolitan Planning Organization

    2009-12-09T23:59:59.000Z

    Project Selection ?????????????????????...... 2-1 Intermodal Facilities & West Rail Project ???????.??????.. 2-1 thru 2-5 Airport Transportation/Air Cargo ?????????????????. 2-5 thru 2-6 International Border Crossings ??????????????????... 2-6 thru 2... and the Union Pacific Railraod tracks. The TxDOT contract for these F.M. 511 construction activities is worth approximately 44.2 million dollars. This F.M. 511 widening project, by itself, may not seem very remarkable. However, if one considers...

  19. The Manchester Metropolitan University Financial Statements

    E-Print Network [OSTI]

    The new Business School and Student Hub is an award-winning building constructed to the highest standards of energy efficiency and sustainable development. The building provides an inspirational learning and Financial Review The Governors submit the University's annual report and audited consolidated financial

  20. Metropolitan Edison Co (Pennsylvania) | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual SiteofEvaluatingGroup |JilinLu an GroupInformation Meier(Redirected fromMetlakatla

  1. Quine's NF---60 years on Thomas Forster

    E-Print Network [OSTI]

    Forster, T.E.

    twentieth century mathematicians used the expression ``The Crisis in Foundations''. This crisis had many in the form of Russell's paradox, appropriately in the heart of set theory. At first blush one might think

  2. Migration Strategies towards All Optical Metropolitan Access Rings

    E-Print Network [OSTI]

    Aracil, Javier

    , in order to cope with the traffic increase and, most importantly, in order to reduce the CAPEX and OPEX reducing the CAPEX and OPEX of existing active technologies based on SDH/SONET rings and Ethernet star

  3. Tulsa Metropolitan Area Destination 2030 Long Range Transportation Plan

    E-Print Network [OSTI]

    Indian Nations Council of Governments

    OP 151 OP 20 tu 64 ??? 44 ??? 244 ??? 44 ??? 44 tu 75 tu 412 tu 75A tu 169 tu 64 Cherokee Industrial Park Tulsa Airport Area 21st & Utica Corridor BA Expressway & US 169 Corridor South Yale Corridor Port of Catoosa 116th 106th 126th Pine 36th 146th... International Airport Port of Catoosa Johnston's Port 33 116th 106th 126th Pine 36th 146th 166th 56th Uni o n 46th 171st Y a l e 3 3 r d W 161st P e o r i a M i n g o 1 2 9 t h W E l w o o d Apache 1 2 9 t h Admiral 151st 8 1 s t W L e w i s G a r n e t t 9 7...

  4. Victoria Metropolitan Transportation Plan Update 2005-2030

    E-Print Network [OSTI]

    Victoria Metropolitan Planning Organization

    arrived instead at the Texas Gulf Coast and established Fort St. Louis on Garcitas Creek in southeast Victoria County. He brought with him roughly 280 colonists. While a majority of the colonists remained at the fort, La Salle explored the region... arrived instead at the Texas Gulf Coast and established Fort St. Louis on Garcitas Creek in southeast Victoria County. He brought with him roughly 280 colonists. While a majority of the colonists remained at the fort, La Salle explored the region...

  5. CONTAINER MOVEMENT BY TRUCKS IN METROPOLITAN NETWORKS: MODELING

    E-Print Network [OSTI]

    Dessouky, Maged

    , Maged Dessouky , Petros Ioannou , and Anastasios Chassiakos * Department of Electrical Engineering Engineering, University of Southern California, Los Angeles, CA 90089-0193 *** College of Engineering/LB) twin ports, the U.S. largest ocean freight hub and busiest container port complex, has been quite

  6. Title of Project: Asset Management and Metropolitan Planning Organizations

    E-Print Network [OSTI]

    Illinois at Chicago, University of

    use of Soft Systems Methodology (SSM). SSM is a qualitative approach to intervene in complex problem literature review regarding asset management tools and the use of Soft Systems Methodology (SSM) 2) Review the hurdles presented by the human activity system. It is in this context that this project will contribute

  7. accra metropolitan area: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    that the role of transmission in the development of competitive markets in wholesale electric power in the US. We discuss the various developments on both the legislative and...

  8. Jonesboro Metropolitan Planning Organization 2030 Long Range Transportation Plan 

    E-Print Network [OSTI]

    Jonesboro Metropolitan Planning Organization

    2005-01-01T23:59:59.000Z

    Committee meets monthly to address specific development topics including updating the long-range planning process, involvement at public information meetings, developing goals and objectives, and alternatives analysis. The group identified key issues... 1-2 Policy Committee 1-2 Technical Advisory Committee 1-2 Public Involvement 1-2 Round 1 Public Involvement 1-3 Round 2 Public Involvement 1-3 Round 3 Public Involvement 1-4 Final Public Meeting and Document Review Period 1-4 Analysis 1...

  9. Green Roofs in the New York Metropolitan Region

    E-Print Network [OSTI]

    .....................................................................................1 Cynthia Rosenzweig, Stuart Gaffin, and Lily Parshall I. Data Analysis and Modeling Energy Balance Daniel Braman, Paul D. Schreiber High School, Port Washington, NY Jennifer Cox, Hunter College, City Hodges, Hunter College, City University of New York Paul Mankiewicz, Gaia Institute Franco Montalto, e

  10. THE MANCHESTER METROPOLITAN UNIVERSITY FACULTY OF SCIENCE AND ENGINEERING

    E-Print Network [OSTI]

    period, as an employee of your company, they will be expected to behave as a responsible member of your staff, and will be subject to company rules and discipline. We have particularly stressed: working. During the placement, we expect students to keep a log book, in which they make regular entries

  11. METROPOLITAN REPORT Economic Indicators for the New Orleans Area

    E-Print Network [OSTI]

    Kulp, Mark

    , about 0.9% or 1.1 million jobs were added across the U.S, and initial unemployment claims went down 13. Still, some industries, like construction, are still damaged. According to Portland Cement Association, construction is expected to recov

  12. atlanta georgia metropolitan: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of 2004. Five notable plumes of SO2, apparently from coal-fired power plants, were Weber, Rodney 12 ACI Spring Convention Atlanta Georgia Engineering Websites Summary:...

  13. Choosing the Right Metropolitan Ring for Your Business

    E-Print Network [OSTI]

    Fisher, Kathleen

    to the node (i.e. "on ramp"), and are configured to the speed and protocol of the requested service. Nodes

  14. You give me fever : practical protection for metropolitan neuroses

    E-Print Network [OSTI]

    Case, Keith William

    2010-01-01T23:59:59.000Z

    The emergence of Swine Flu in the past six months has once again heightened the world's fears of a coming flu pandemic. Although H1N1 is only slightly more pathogenic than the common seasonal flu, which kills approximately ...

  15. Planning for mitigating climate change risk to metropolitan areas (USA)

    E-Print Network [OSTI]

    Grover, Himanshu

    2009-06-02T23:59:59.000Z

    In the last couple of decades, there has been increasing evidence of changes in global climate. With urban areas identified as the primary contributors to the climate change, there is an impetus for initiatives to persuade major contributors...

  16. Texarkana Urban Transportation Study 2035 Metropolitan Transportation Plan

    E-Print Network [OSTI]

    Texarkana Metropolitan Planning Organization

    2009-10-01T23:59:59.000Z

    This page intentionally left blank. TUTS 2035 PLAN i October 1, 2009 TABLE OF CONTENTS 1 INTRODUCTION 4 OPERATIONS & MANAGEMENT What is the MPO? 1-1 O&M Goals 4-2 What does the MPO do? 1-1 O&M Strategies 4-2 Challenges...-7 TUTS 2035 PLAN ii October 1, 2009 7 PUBLIC TRANSPORTATION Amtrak-Passenger Rail Service 7-1 Texarkana Regional Airport 7-2 Greyhound Intercity Bus Service 7-4 Texarkana Urban Transit District Public Transportation 7-4 TRAX ? Rural Public...

  17. Planning for mitigating climate change risk to metropolitan areas (USA) 

    E-Print Network [OSTI]

    Grover, Himanshu

    2009-06-02T23:59:59.000Z

    In the last couple of decades, there has been increasing evidence of changes in global climate. With urban areas identified as the primary contributors to the climate change, there is an impetus for initiatives to persuade major contributors...

  18. THE MANCHESTER METROPOLITAN UNIVERSITY DIVERSITY AND EQUAL OPPORTUNITIES COMMITTEE

    E-Print Network [OSTI]

    off after 30 years; · Student numbers would be controlled by determining a minimum UCAS tariff points education. However, as eligibility for SF was dependent on obtaining a minimum UCAS tariff points score

  19. MetropoLitan CoLLege graduate prograMS

    E-Print Network [OSTI]

    Finzi, Adrien

    is certified by the State Council of Higher Education to operate in Virginia. #12;H3bu.edu/military PMi® a Institute's Global Accreditation Center (GAC): · Master of science in Computer information systems PMI® is the leading membership association for the project management profession. For more information, visit pmi

  20. Open space system study for the Dacca metropolitan area

    E-Print Network [OSTI]

    Rab, Wajeda Jafar

    1970-01-01T23:59:59.000Z

    and aspirations of 70 million of East Pakistan and 120 zillion people of Pakistan. A propor- tio 'ate distribution of the national capital building is desirable. So far Karachi and Islamabad have been successively developed as the admiristrative seats... of the national government at an estimated cost of Rs. 8, 000, 000, 000 end Rs. 4, 000, 000, 000 respectively. The capital building activity of Islamabad has just begun. Dacce. es the legislative seat of the nation has as its share only R . . 20, 000, 000...

  1. METRA -Metropolitan Rail Corporation Chicago, Illinois Posting Date

    E-Print Network [OSTI]

    Bustamante, Fabián E.

    includes approximately 400 employees classified as journeymen or apprentice electricians, machinist, Carmen

  2. The 2005 - 2030 Harlingen-San Benito Metropolitan Transportation Plan

    E-Print Network [OSTI]

    Harlingen-San Benito Metropolitan Planning Organization

    2004-12-29T23:59:59.000Z

    construction program for the MPO. It lists what projects will be constructed in the MPO urbanized area and in what fiscal year they will be let. (Let means when the contract will be awarded.) The TIP is updated every two fiscal years (FY 1999, 2001, 2003... the MPO study area experienced significant increases in population, and increased population and growth are projected to continue through the 25-year study period for the Harlingen-San Benito MPO and the Lower Rio Grande Valley as a whole. 1...

  3. Teito Tokyo: Empire, Modernity, and the Metropolitan Imagination

    E-Print Network [OSTI]

    Goddard, Timothy Unverzagt

    2013-01-01T23:59:59.000Z

    on several levels of glass shelving, stood in double image,succession off their high shelving and crashed to the floor.

  4. Racial Segregation and Educational Outcomes in Metropolitan Boston

    E-Print Network [OSTI]

    Lee, Chungmei

    2004-01-01T23:59:59.000Z

    Worcester, Leominster, Attleboro, Fall Comfort ex rel.Asian Satellite Cities Attleboro Brockton Cambridge ChelseaM C A S Rates Boston Attleboro Brockton Cambridge Chelsea

  5. Los Angeles County Metropolitan Transportation Authority Metro | Open

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere I Geothermal Pwer Plant Jump to:Landowners andLodgepole, Nebraska:LongboardLoretto,

  6. METROPOLITAN REPORT Economic Indicators for the New Orleans Area

    E-Print Network [OSTI]

    Kulp, Mark

    data through April to exclude the sizeable impact of the BP Horizon oil spill, because its purpose is to analyze the net recovery from Hurricane Katrina. Later issues of this report will address the BP oil spill

  7. Chicago Metropolitan Agency for Planning Data Dashboard | Department of

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO OverviewAttachments4 Chairs Meeting - April 2014 DOE-HDBK-1139/1-2006 MayEnergy Data

  8. Chicago Metropolitan Agency for Planning Summary of Reported Data |

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO OverviewAttachments4 Chairs Meeting - April 2014 DOE-HDBK-1139/1-2006 MayEnergy

  9. Climate Action Champions: Metropolitan Washington Council of Governments,

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO OverviewAttachments4 Chairs Meeting - AprilEvents Clean EnergyofDepartment of0211W HDC, MD,

  10. Metropolitan Edison Company SEF Grants (FirstEnergy Territory) | Department

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy ChinaofSchaeferApril 1,(EAC) Richard2015 RDSHARP SupportingMarchof Energy Local

  11. Metropolitan Water District of S CA | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual SiteofEvaluatingGroup |JilinLu an GroupInformation Meier(Redirected

  12. Alternative Fuels Data Center: Metropolitan Utilities District Fuels

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041cloth DocumentationProductsAlternative Fuels CleanReduce OperatingPropane in Ohio

  13. Cloning and expression of equine NF-kB2

    E-Print Network [OSTI]

    Mirhosseini, Negin

    2009-05-15T23:59:59.000Z

    ., 2005). EIAV is transmitted mechanically by either an insect vector or an infected needle. EIAV causes a persistent infection which is typically classified in three defined stages: acute, chronic, and long-term asymptomatic (Leroux et al., 2001...). Initial exposure of an animal to a virulent strain usually results in an acute disease (Leroux et al., 2004; Maury, 1998). The acute stage of disease usually resolves within a few days 1...

  14. NF kappa B expression and matrix metalloproteinase activity in hypertension

    E-Print Network [OSTI]

    Wu, Kwan-I

    2009-01-01T23:59:59.000Z

    J. Silica attenuates hypertension in Lyon hypertensive rats.to experimental hypertension. J. Exp. Med. 115(6):1173-1190,Hypertensive Rat. Hypertension 52(2):415-423, 2008. Fabunmi

  15. NF 3 , the greenhouse gas missing from Kyoto

    E-Print Network [OSTI]

    Prather, Michael J; Hsu, Juno

    2008-01-01T23:59:59.000Z

    Moreover, there is an economic incentive, a tradeoff betweenthere are economic as well as environmental incentives not

  16. Distinct functions of negative regulators of NF-kappaB

    E-Print Network [OSTI]

    Kearns, Jeffrey D.

    2009-01-01T23:59:59.000Z

    Kearns JD, Cheong R, Hoffmann A, Levchenko A. (2005) “S, Werner SL, Huang CS, Hoffmann A. (2006) “I?B? providesWare CF, Ghosh G, Verma IM, Hoffmann A. (2007) “A fourth I?B

  17. Distinct functions of negative regulators of NF-kappaB

    E-Print Network [OSTI]

    Kearns, Jeffrey D.

    2009-01-01T23:59:59.000Z

    J Immunol 174: 983-991. Emmerich F, Theurich S, Hummel M,specific (Doerre et al, 2005; Emmerich et al, 2003; Memet etDoerre et al, 2005; Emmerich et al, 2003; Memet et al, 1999;

  18. CMRR-NF Supplemental EIS Scoping Comments | National Nuclear Security

    National Nuclear Security Administration (NNSA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA groupTubahq.na.gov Office of the

  19. ARM - VAP Product - aerich1nf1turn

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa-AnomalousProductsabrfcabrfcprecip Documentation abrfc : XDC documentation

  20. ARM - VAP Product - aerich2nf1turn

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa-AnomalousProductsabrfcabrfcprecip Documentation abrfc : XDC

  1. An Assessment of Air Service Accessibility in U.S. Metropolitan Regions, 2007-2012

    E-Print Network [OSTI]

    Wittman, M.D.

    2014-05-20T23:59:59.000Z

    Regional accessibility to air transportation is often of interest to airport executives, politicians, and the general public due to the positive economic impacts of frequent commercial airline service. However, measuring ...

  2. Analysis of The Housing Market in the Metropolitan Areas in the United States

    E-Print Network [OSTI]

    Li, Yarui

    2013-12-04T23:59:59.000Z

    that economics dominates geography in terms of differentiating housing markets (Gyourko and Voith, 1992; Jud and Winkler, 2002; Chan, Ng and Ramchand, 2012). House prices are found to facilitate classifying homogeneous housing market and so are other elements... of attributes varies by geographical region and over time with property size and economic and demographical attributes being the key variables explaining asking price formation. The paper by Capozza, Hendershott, Mack and Mayer (2002) explores...

  3. Jefferson Orange Hardin Regional Transportation Study 2007 Metropolitan Transportation Plan - 2030

    E-Print Network [OSTI]

    South East Texas Regional Planning Commission

    2007-04-12T23:59:59.000Z

    . Average 4 th Highest Daily Maximum Eight-Hour Ozone Levels Per Three Year Period SETRPC Monitoring Sites TCEQ Monitoring Sites Years Sabine Pass Mauriceville SE Tex. Reg. Airport Port Arthur Beaumont Hamshire West Orange 97-99 0.099 0... construction projects. The successor to ISTEA, the Transportation Equity Act for the 21 st Century (TEA-21) was passed by Congress in 1998. This legislation continued to promote system preservation while increasing funding of transit and other...

  4. Mobility 2030: The Metropolitan Transportation Plan for the Dallas-Fort Worth Area 2009 Amendment

    E-Print Network [OSTI]

    North Central Texas Council of Governments

    2009-04-09T23:59:59.000Z

    the airports via DART light rail. DCTA will connect to the system in Carrollton. ? Review surface access to aviation and related changes over time. St udy alternative access and congestion scenarios at commercial airports based on alternative air travel... Dallas/Fort Worth International Airport Kathryn Wilemon Councilm e m b e r, City of Arlingt on Michael Morris, P.E. Director of Transportation, NCTC OG Surface Transportation Technical Committee Jim Sparks, Chair City of Grand Prairi e...

  5. ManchesterMetropolitanUniversityCareers&EmployabilityService How to...plan time out

    E-Print Network [OSTI]

    of the options you are considering whilst you take stock of your short and long term career objectives. How graduation www.mmu.ac.uk/careers Oct 2012 It is increasingly common for graduates to consider taking time out taking a year out to build up your employability skills You need to explore your options before making

  6. Manchester Metropolitan University, the owners of the former Alsager Campus, will soon make an

    E-Print Network [OSTI]

    Context Map job drawing rev 6001 SP(90)15 - chadsworth house wilmslow road handforth cheshire sk9 3hp tel and the highway network. The site has minimal ecological constraints, and the proposed residential development

  7. Facebook, Writing and Language Learner Variables at a Large Metropolitan Community College

    E-Print Network [OSTI]

    Dixon, Gregory A.

    2011-05-31T23:59:59.000Z

    This study gathered information on student engagement with Facebook, and described non-native English speakers' (NNS) expectations and experience. This also assessed the relationship this technology has with writing efficacy and compared NNS...

  8. An ozone episode in the Philadelphia metropolitan area Lawrence I. Kleinman,1

    E-Print Network [OSTI]

    and Structure: Pollution--urban and regional (0305); 0365 Atmospheric Composition and Structure: Troposphere follows population density, there are locations within the corridor with a concentration of electric and the Ohio River Valley, are large coal-fired power plants with high emissions of SO2 and NOx. Meteorological

  9. Chemical evolution of volatile organic compounds in the outflow of the Mexico City Metropolitan area

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    Methanol Ethanol Acetone MEK MTBE CO Methane UCI UCI TOGA/methyl tertiary butyl ether (MTBE), and toluene all ratioedthe observed decay. For MTBE, also a species that is not

  10. An Analysis of the Impacts of British Transport Reforms on Transit Integration in the Metropolitan Areas

    E-Print Network [OSTI]

    Rivasplata, Charles Richard

    2006-01-01T23:59:59.000Z

    and C. Nash, 1995. Bus deregulation: ten years on, TransportFN Spon. ________, 1996. Deregulation and privatization: theand N. Topham (Eds. ), Bus Deregulation and Privatisation,

  11. Economic Fundamentals in Local Housing Markets: Evidence from U.S. Metropolitan Regions

    E-Print Network [OSTI]

    Hwang, Min; Quigley, John M.

    2006-01-01T23:59:59.000Z

    Economic Activity, 2, 143–183. Quigley, John M. , and Larryrsthm@nus.edu.sg John M. Quigley Department of Economics,land-use regulations. See Quigley and Rosenthal (2005) for a

  12. Economic fundamentals in local housing markets: Evidence from US metropolitan regions

    E-Print Network [OSTI]

    Hwang, Min; Quigley, John M.

    2006-01-01T23:59:59.000Z

    Peter Englund, John M. Quigley, and Christian Redfearn.Hwang, Min, John M. Quigley, and Jae Young Son. 2005. “TheActivity, 2, 143-183. Quigley, John M. and Larry Rosenthal.

  13. Economic Fundamentals in Local Housing Markets: Evidence from U.S. Metropolitan Regions

    E-Print Network [OSTI]

    Hwang, Min; Quigley, John M.

    2006-01-01T23:59:59.000Z

    2, 143–183. Quigley, John M. , and Larry Rosenthal. 2005. “Peter Englund, John M. Quigley, and Christian Redfearn.Press. Hwang, Min, John M. Quigley, and Jae Young Son.

  14. Economic fundamentals in local housing markets: Evidence from US metropolitan regions

    E-Print Network [OSTI]

    Hwang, Min; Quigley, John M.

    2006-01-01T23:59:59.000Z

    Activity, 2, 143-183. Quigley, John M. and Larry Rosenthal.Peter Englund, John M. Quigley, and Christian Redfearn.Press. Hwang, Min, John M. Quigley, and Jae Young Son.

  15. METRA (Metropolitan Rail Corporation) Posting Period Chicago May 23 June 6, 2014

    E-Print Network [OSTI]

    Bustamante, Fabián E.

    including design of relay interlocking, application of essential signaling equipment such as Microlok, VPI include the use of Ladder, Relay and Boolean. § Project management experience is preferred. § Must have to a physical examination/drug test and background check to verify information regarding education, employment

  16. Geographically varying associations between personality and life satisfaction in the London metropolitan area

    E-Print Network [OSTI]

    Jokela, Markus; Rentfrow, Peter J.; Bleidorn, Wiebke; Lamb, Michael E.; Gosling, Samuel D.

    2015-01-12T23:59:59.000Z

    individual dispositions and neighborhood characteristics. Methods Participants Participants were from the Big Personality Test online survey advertized and hosted by the British Broadcasting Corporation (BBC) on its Lab UK website (https://ssl... TC (1985) Urbanism and tolerance: A test of some hypotheses drawn from Wirth and Stouffer. American Sociological Review. 17. uk MC ed. The Busiest Stations on the London Underground (mapsdata.co.uk) Available at: http://www.mapsdata.co.uk/portfolio...

  17. Executive Summary The Morgantown metropolitan statistical area (MSA) continued to expand in 2011, adding jobs

    E-Print Network [OSTI]

    Mohaghegh, Shahab

    job gains in natural resources and mining (new coal mine and continued development of the Marcellus. In addition, state and federal budgets are likely to tighten during the forecast, putting pressure on spending OF BUSINESS AND ECONOMIC RESEARCH COLLEGE OF BUSINESS AND ECONOMICS WEST VIRGINIA UNIVERSITY www

  18. A comparative study of ozone production in five U.S. metropolitan areas

    E-Print Network [OSTI]

    olefins are coemitted from petrochemical facilities leading to the highest P(O3)s of the five cities

  19. OPENING DAY OF THE MARYLAND AGRICULTURAL COLLEGE SOWING THE SEEDS OF A MODERN METROPOLITAN RESEARCH UNIVERSITY

    E-Print Network [OSTI]

    Rubloff, Gary W.

    to be one of the chief ornaments of the premises in time."1 The main building which was the location hundred students, and is so constructed as to insure the most perfect ventilation, and to afford every

  20. Real-time Air Quality Monitoring Through Mobile Sensing in Metropolitan Areas

    E-Print Network [OSTI]

    Iftode, Liviu

    . General Terms Measurement, Design, Experimentation, Human Factors. Keywords Air Quality, Pollution, Urban levels in the urban and suburban settings. According to the US EPA [3], the six common air pollutants. These are called the criteria pollutants and thus are required to be measured to tell us how healthy the air

  1. Urban growth pattern and sustainable development: a comparative study of municipalities in the Seoul Metropolitan Region 

    E-Print Network [OSTI]

    Paek, Seunggeun

    2006-10-30T23:59:59.000Z

    , environmental protection, and social equity (Agyeman & Evans, 2003; Campbell, 1996; World Bank, 2003). The sustainability agenda is a major global issue and at the same time a local issue. Sustainability is seen to be meaningful and achievable only when... in achieving sustainable development goals, Agenda 21, a comprehensive global blueprint for sustainable development adopted by the 1992 Earth Summit, recommends that local authorities adopt a local Agenda 21. Local Agenda 21 is community-based processes...

  2. Economic Fundamentals in Local Housing Markets: Evidence from U.S. Metropolitan Regions

    E-Print Network [OSTI]

    Hwang, Min; Quigley, John M.

    2006-01-01T23:59:59.000Z

    estimate capital gains assuming AR- GARCH processes for eachreturns, follows AR(4)-GARCH (1,1), that is, (B1) r t = ? 0

  3. Economic fundamentals in local housing markets: Evidence from US metropolitan regions

    E-Print Network [OSTI]

    Hwang, Min; Quigley, John M.

    2006-01-01T23:59:59.000Z

    estimate capital gains assuming AR-GARCH processes for eachreturns, follows AR(4)-GARCH ( 1,1), i.e. , (B.1) where t k

  4. Chemical evolution of volatile organic compounds in the outflow of the Mexico City Metropolitan area

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    C-130 T0 T1 G1 Ethane Propane i-Butane n-Butane i-Pentane n-ppbv) Ethane Ethene Ethyne Propane Propene i-Butane n-Butanee.g. , ethane, ethene, propane, propane, methanol, ethanol,

  5. Modeling the Dynamics of Desakota Regions: Global - Local Nexus in the Taipei Metropolitan Area

    E-Print Network [OSTI]

    Wu, Bing-Sheng

    2010-10-12T23:59:59.000Z

    Since the 1970s, Asia has experienced rapid urbanization processes, which are distinct from U.S. society, and the direction of Asian urbanization is more strongly affected by economic globalization. The desakota model, proposed by McGee and Ginsburg...

  6. publication 420-050 Learning to Live with Coyotes in Metropolitan Areas

    E-Print Network [OSTI]

    Liskiewicz, Maciej

    good chance for survival here. Being general- ists, they eat plants, animals, and even garbage. However. Children should tell an adult if they see one. 4. Take your garbage can to the curb on the morning of your

  7. Planners and the Pork Barrel: Metropolitan Engagement in and Resistance to Congressional Transportation Earmarking

    E-Print Network [OSTI]

    Sciara, Gian-Claudia

    2009-01-01T23:59:59.000Z

    the new public management (NPM) perspective that has gainedthe 1980s. Advocates of the NPM emphasize diminishing faith

  8. Planners and the Pork Barrel: Metropolitan Engagement in and Resistance to Congressional Transportation Earmarking

    E-Print Network [OSTI]

    Sciara, Gian-Claudia

    2009-01-01T23:59:59.000Z

    resembles the new public management (NPM) perspective thatfederal funding cuts. As new public management theory gainedpublic management, including decentralized decisionmaking and flexible government. 77 New

  9. Planners and the Pork Barrel: Metropolitan Engagement in and Resistance to Congressional Transportation Earmarking

    E-Print Network [OSTI]

    Sciara, Gian-Claudia

    2009-01-01T23:59:59.000Z

    Guarantee (Sec. 1104) Equity Bonus (Sec. 1104) Yes. AllRABA Bonus. 158 Recyclingrevenue (so-called RABA bonus); (6) rescinding previously

  10. The Political-Economic and Demographic Causes of Metropolitan Income Inequality and Its Components

    E-Print Network [OSTI]

    Chen, XI

    2010-07-14T23:59:59.000Z

    by standardizing pay among them within industrial units, e.g. plant, factory, or firm, but also equalize pay across units and reduce inequality by narrowing the earning gap between blue collar workers and highly paid professionals and executives. Furthermore... in various industrial and occupational categories. The most widely discussed demand-side factors 22 in studies on income inequality include industrial and occupational structure, size of the public sector, racial inequality caused by discrimination...

  11. Technology and policy options for reducing industrial air pollutants in the Mexico City Metropolitan Area

    E-Print Network [OSTI]

    Vijay, Samudra, 1968-

    2005-01-01T23:59:59.000Z

    Technology plays an important role in dealing with air pollution and other environmental problems faced by developing and developed societies. This research examines if technological solutions alone, such as end-of-pipe ...

  12. Vulnerability of the New York City Metropolitan Area to Coastal Hazards,

    E-Print Network [OSTI]

    moved from a manufacturing to a service industry-based economy. Mid-town and Lower Manhattan are two on Long Island, NY, and the north- ern New Jersey shore. Beaches and coastal wetlands provide recreational at or near sea level. Major coastal urban centers have long been vulnerable to natural hazards, such as storm

  13. Economic Fundamentals in Local Housing Markets: Evidence from U.S. Metropolitan Regions

    E-Print Network [OSTI]

    Hwang, Min; Quigley, John M.

    2006-01-01T23:59:59.000Z

    patterns of house price development are depicted in Figurethe predicted housing price developments from the same model

  14. Economic fundamentals in local housing markets: Evidence from US metropolitan regions

    E-Print Network [OSTI]

    Hwang, Min; Quigley, John M.

    2006-01-01T23:59:59.000Z

    patterns of house price development are To accomplish this,the predicted housing price developments from the same model

  15. An Analysis of the Impacts of British Transport Reforms on Transit Integration in the Metropolitan Areas

    E-Print Network [OSTI]

    Rivasplata, Charles Richard

    2006-01-01T23:59:59.000Z

    contrast to many other cities with the smart card system ofthe three case cities. Fare integration: transit smart cardsonly city in the country to have introduced a transit smart

  16. Human Exposure to Toxic Materials The New York-New Jersey Metropolitan Region

    E-Print Network [OSTI]

    Brookhaven National Laboratory

    of facilities for manufacture of lead- acid batteries directly exposes workers to air- borne particles and has, and the food we eat. As an example, con- sider someof the routes for exposureto lead. Lead has been used often brought about substantial pollution of the surrounding land. Run-off carrying lead from the site

  17. Public perceptions of, and attitudes toward, crime in the parks of a major metropolitan area

    E-Print Network [OSTI]

    Conway, Kenneth Lee

    1980-01-01T23:59:59.000Z

    , Davis Chairman of Advisory Committee: Dr. John L. Crompton Research was conducted to examine whether the perception of high crime and illegal activity levels in Austin parks was related to non- use or low use of these parks. An attempt was made... to determine which types of illegal activities Austin citizens were most sensitive to and how often they perceived these illegal activities to occur in Austin parks. Also, those crimes that most discouraged visitation were iden- tified, along with crime...

  18. Planners and the Pork Barrel: Metropolitan Engagement in and Resistance to Congressional Transportation Earmarking

    E-Print Network [OSTI]

    Sciara, Gian-Claudia

    2009-01-01T23:59:59.000Z

    MPOs, and other eligible grantees to submit applications forTEA-21 requires that Job Access grantees be selected on aoutside these traditional grantees, such as minor local

  19. Formation of semivolatile inorganic aerosols in the Mexico City Metropolitan Area during the MILAGRO campaign

    E-Print Network [OSTI]

    Karydis, V. A.

    One of the most challenging tasks for chemical transport models (CTMs) is the prediction of the formation and partitioning of the major semi-volatile inorganic aerosol components (nitrate, chloride, ammonium) between the ...

  20. Car Based Transport and Transit Oriented Metropolitan —— Chinese Urban Motorization Pathways

    E-Print Network [OSTI]

    Ximing, Lu

    2008-01-01T23:59:59.000Z

    their travel times. Car sharing is rising in importance inand DeLisi, 2000). Various car-sharing companies provideof car ownership. Car sharing is growing rapidly in Europe,

  1. Sustainable metropolitan mobility and public-private partnerships : a highway to institutional reform?

    E-Print Network [OSTI]

    Grillo, Christopher C. (Christopher Charles)

    2011-01-01T23:59:59.000Z

    The "sustainability" literature generally acknowledges a critical role for transportation infrastructure planning, finance, investment, design, construction, operation, and management for addressing the long-term viability ...

  2. Overview of The Ariel Sharon (Ayalon) Park PARK ARIEL SHARON TEL AVIV METROPOLITAN GEM

    E-Print Network [OSTI]

    Sadeh, Norman M.

    recycling and solid waste treatment center, a midsize neighborhood park, and Mikve Israel School's protected" Mikve Israel is occurring, advanced technologies of recycling are incorporated into the solid waste treatment park, Hyria waste Mountain is rehabilitated as park, the land is being acquired, and funds

  3. A plan for Metropolitan State Hospital : imagery as a therapy for an institution

    E-Print Network [OSTI]

    McMurrin, Sterling James

    1988-01-01T23:59:59.000Z

    This thesis is both text and illustration to describe the process of transforming a state mental institution from an outdated, outmoded, conventional hospital into a living community. The goal of the project is to develop ...

  4. The Origins of Metropolitan Transportation Planning in Travel Demand Forecasting, 1944-1962

    E-Print Network [OSTI]

    Deutsch, Cheryl

    2013-01-01T23:59:59.000Z

    J. (1955). The law of retail gravitation applied to trafficas “Reilly’s Law of Retail Gravitation. ” Concepts like

  5. A policy story of continuity and change : reflections on the Obama Administration's Metropolitan Agenda

    E-Print Network [OSTI]

    Ullah, Athena Jade

    2011-01-01T23:59:59.000Z

    President Obama was sworn into office on January 20, 2009 and within the first month of his presidency, against a backdrop of staggering concerns about financial reform, energy efficiency, and the need to allocate $787 ...

  6. Emission Testing of Washington Metropolitan Area Transit Authority (WMATA) Natural Gas and Diesel Transit Buses

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power AdministrationField Campaign:INEAWater UseCElizabethTwo States CARLSBAD,Emilio

  7. Chicago Metropolitan Agency for Planning Summary of Reported Data From July 1, 2010 - September 30, 2013

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: Theof EnergyAdministration-DesertofSuccessTroy

  8. DeKalb County/Metropolitan Atlanta Alternative Fuel and Advanced Technology

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny:Revised Finding of No53197 This workDayton: ENERGY STAR Referral (5NTX1)

  9. DeKalb County/Metropolitan Atlanta Alternative Fuel and Advanced Technology

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny:Revised Finding of No53197 This workDayton: ENERGY STAR Referral (5NTX1)Vehicle

  10. DeKalb County/Metropolitan Atlanta Alternative Fuel and Advanced Technology

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny:Revised Finding of No53197 This workDayton: ENERGY STAR Referral

  11. Washington Metropolitan Area Transit Authority: Biodiesel Fuel Comparison Final Data Report

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron SpinPrincetonUsing Maps1DOE AwardsD ContractBOE Reserve

  12. Insights into the regulation of NF-kappaB and mediation of the cellular stress response by NF-kappaB

    E-Print Network [OSTI]

    Ho, Jessica Q.

    2010-01-01T23:59:59.000Z

    Cancer Res 65, 4273-4281. Hoffmann, A. , Natoli, G. , andS.L. , Huang, C.S. , and Hoffmann, A. (2006). IkappaBepsilonK.I. , DiDonato, J.A. , Hoffmann, A. , Hardwick, J.M. , and

  13. Valuing Rail Transit: Comparing Capital and Operating Costs to Consumer Benefits

    E-Print Network [OSTI]

    Guerra, Erick

    2010-01-01T23:59:59.000Z

    of Allegheny County Tri-County Metropolitan Transportationof Allegheny County Tri-County Metropolitan Transportationof Allegheny County Tri-County Metropolitan Transportation

  14. Cities in Times of Crisis: The Response of Local Governments in Light of the Global Economic Crisis: the role of the formation of human capital, urban innovation and strategic planning

    E-Print Network [OSTI]

    Cohen, Manuel Perlo

    2011-01-01T23:59:59.000Z

    Metropolitan   Area     Campeche                    quarter  in  2010,  Campeche  recorded  an  unemployment  

  15. The Aoki phase for N_f=2 Wilson fermions revisited

    E-Print Network [OSTI]

    Sternbeck, A; Kerler, W; Müller-Preussker, M; Stüben, H

    2004-01-01T23:59:59.000Z

    We report on a numerical reinvestigation of the Aoki phase in full lattice QCD with two flavors of unimproved Wilson fermions. For zero temperature the Aoki phase can be confirmed at inverse coupling $\\beta=4.0$ and $\\beta=4.3$, but not at $\\beta=4.6$ and $\\beta=5.0$. At non-zero temperature the Aoki phase was found to exist also at $\\beta=4.6$.

  16. A partially quenched analysis of the eta-eta' system in N_f=2 QCD

    E-Print Network [OSTI]

    Neff, H; Negele, John W; Schilling, K; Lippert, Th.

    2004-01-01T23:59:59.000Z

    We report on a first, comprehensive partially quenched study of the eta-eta' problem, based on SESAM configurations on a 16^3x32 lattice at beta=5.6 QCD with two (mass degenerate) active sea quark flavours. By means of the spectral approximation of the two-loop (hairpin) diagrams, we find clear plateau formation in the effective masses which enables us both to determine the eta-eta' mass matrix and the alpha-parameter in the effective chiral Lagrangian for the flavour singlet sector, alpha=0.028 +- 0.013.

  17. Probing the Aoki phase with N_f=2 Wilson fermions at finite temperature

    E-Print Network [OSTI]

    Ilgenfritz, E M; Müller-Preussker, M; Sternbeck, A; Stüben, H

    2005-01-01T23:59:59.000Z

    In this letter we report on a numerical investigation of the Aoki phase in the case of finite temperature which continues our former study at zero temperature. We have performed simulations with Wilson fermions at $\\beta=4.6$ using lattices with temporal extension $N_{\\tau}=4$. In contrast to the zero temperature case, the existence of an Aoki phase can be confirmed for a small range in $\\kappa$ at $\\beta=4.6$, however, shifted slightly to lower $\\kappa$. Despite fine-tuning $\\kappa$ we could not separate the thermal transition line from the Aoki phase.

  18. NF-[kappa]B RelB/p52 heterodimer : biogenesis and DNA recognition

    E-Print Network [OSTI]

    Fusco, Amanda J.

    2007-01-01T23:59:59.000Z

    derived factor-1 (SDF-1), B lymphocyte chemoattractant (BLC)Sequence Consensus ELC BLC SDF-1 New Consensus for RelB/p52from the CD39, BLC, ELC and SDF-1 promoters (Figure 3-21).

  19. Gersende Prior NF-FE Meeting November 10th Neutrino Factory

    E-Print Network [OSTI]

    McDonald, Kirk

    long Hg target in 20 T field (SPL+accumulator & compressor ring). Decay: 30 m long in 1.8 T. Rotation the relations: = = ½ = 0 (can we ?) Problems: det(0 ) = 0 2x2 sub to understand the problems or change to a "real" optics code (MAD-X, OPTIM, PATH). - pros: ICOOL not designed

  20. www.nasa.gov/aeronautics NF-2013-05-565-HQ

    E-Print Network [OSTI]

    , emissions and fuel burn. A greener future for aviation holds the promise of new life for airports, because Headquarters 300 E. Street, SW Washington, DC 20546 NASA Facts Green Aviation: A Better Way to Treat the Planet engine emissions, unprecedented traffic jams in the sky, nonstop noise near airports, and more citizens

  1. Effects of water chemistry on NF/RO membrane structure and performance

    E-Print Network [OSTI]

    Mo, Yibing

    2013-01-01T23:59:59.000Z

    contaminants by a membrane bioreactor‚granular activatedA combination of a membrane bioreactor (MBR) and GAC for

  2. Effects of water chemistry on NF/RO membrane structure and performance

    E-Print Network [OSTI]

    Mo, Yibing

    2013-01-01T23:59:59.000Z

    methyl tert-butyl ether (MTBE), benzene, ethylbenzene,TCE** Industrial C 2 HCl 3 MTBE** [48] Industrial C 5 H 12 O

  3. Results of radiological measurements taken in the Niagara Falls, New York, area (NF002)

    SciTech Connect (OSTI)

    Williams, J.K.; Berven, B.A.

    1986-11-01T23:59:59.000Z

    The results of a radiological survey of 100 elevated gamma radiation anomalies in the Niagara Falls, New York, area are presented. These radiation anomalies were identified by a mobile gamma scanning survey during the period October 3-16, 1984, and were recommended for an onsite survey to determine if the elevated levels of radiation may be related to the transportation of radioactive waste material to the Lake Ontario Ordnance Works for storage. In this survey, radiological measurements included outdoor gamma exposure rates at 1 m above the surface; outdoor gamma exposure rates at the surface, range of gamma exposure rates during scan; and uranium, radium, and thorium concentrations in biased surface soil samples. The results show 38 anomalies (35 located along Pletcher Road and 3 associated with other unreleated locations) were found to exceed Formerly Utilized Sites Remedial Action Program (FUSRAP) remedial action guidelines and were recommended for formal characterization surveys. (Since the time of this survey, remedial actions have been conducted on the 38 anomalies identified as exceeding FUSRAP guidelines, and the radioactive material above guidelines has been removed.) The remaining 62 anomalies are associated with asphalt driveways and parking lots, which used a phosphate slag material (previously identified as cyclowollastonite, synthetic CaSiO/sub 3/). This rocky-slag waste material was used for bedding under asphalt surfaces and in general gravel applications. Most of the contaminated soil and rock samples collected at the latter anomalies had approximately equal concentrations of /sup 226/Ra and /sup 238/U and, therefore, are not related to materials connected with the Niagara Falls Storage Site (NFSS), including material that was transported to the NFSS. 13 refs., 7 figs., 14 tabs.

  4. University Square Stratford 1 Salway Road, Stratford, London, United Kingdom, E15 1NF

    E-Print Network [OSTI]

    Cocea, Mihaela

    has fully automatic heating, ventilation and lighting controls which require no manual operation. See. There is no smoking permitted in the premises or grounds area of the USS Building including the garden. #12;4 2

  5. Effects of water chemistry on NF/RO membrane structure and performance

    E-Print Network [OSTI]

    Mo, Yibing

    2013-01-01T23:59:59.000Z

    regulated some PAHs in the drinking water, but only Benzo-a-water of7 ppb, 700 ppb, 1ppm, 10 ppm, respectively [45]. PAHs

  6. Identification of NF-kappaB responsive elements in follistatin related gene (FLRG) promoter

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    : electrophoresis mobility-shift assay FLRG: follistatin related gene FSRP: follistatin-related protein FSTL3 lymphocytic leukemia (B-CLL). FLRG (alternative names: follistatin- related protein, FSRP / follistatin-like-3

  7. A NF-kappaB temporal code to ensure specificity in inflammatory signaling

    E-Print Network [OSTI]

    Werner, Shannon L.

    2009-01-01T23:59:59.000Z

    Kearns, J. , Cheong, R. , Hoffmann, A. , and Levchenko, A.G. , Verma, I.M. , and Hoffmann, A. 2007. A fourth IkappaBWerner, S.L. , Regal, J. , Hoffmann, A. , and Levchenko, A.

  8. Temporal encoding and homeostatic control in the IKK- kappaNF-kappaB signaling system

    E-Print Network [OSTI]

    Barken, Derren

    2007-01-01T23:59:59.000Z

    Nature 415(6868): 180-3. Hoffmann, A. and D. Baltimore (Immunol Rev 210: 171-86. Hoffmann, A. , A. Levchenko, etScience 298(5596): 1241-5. Hoffmann, A. , G. Natoli, et

  9. akt-dependent nf-kappab activation: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    particles, which take energy from an internal replenishable energy depot or ambient medium and transduce it into useful work performed on the environment, in addition to...

  10. Review of NF-IDS Targets Work Programme Status C. Densham, RAL, 17 November 2009

    E-Print Network [OSTI]

    McDonald, Kirk

    and services ? e) Cost of mercury system ? f) Cost of remote handling systems including shielding required ? g & containment TD Stalled c) Studies of irradiation, heat loads and cooling of decay solenoid JB, PL Underway d) Heat loads and cooling of shielding PL Stalled e) Solenoid system engineering, magnetic loads PL

  11. attenuates nf-kappab-dependent icam-1: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and borehole acoustic models. The validity of the scheme is established using a 3D homogenous isotropic ... Krasovec, Mary L. 2003-01-01 29 THE ATTENUATED RAY TRANSFORM...

  12. Spatial dimensions of workplaces and the effects on commuting: the dase of metropolitan Dallas-Fort Worth

    E-Print Network [OSTI]

    Shin, Sangyoung

    2004-09-30T23:59:59.000Z

    Sang-Chuel Choe in Seoul National University and to Professor Yang-Choon Park in Kyungpook National University. Thanks to all not listed in this page but deserving of credits. vii TABLE OF CONTENTS Page ABSTRACT g46g46g46g46g46g46g46g46g46g46...g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g46g...

  13. Project identification and evaluation techniques for transportation infrastructure : assessing their role in metropolitan areas of developing countries

    E-Print Network [OSTI]

    Kumar, Vimal, S.M. Massachusetts Institute of Technology

    2009-01-01T23:59:59.000Z

    Project identification and evaluation of transportation infrastructure play a vital role in shaping and sustaining the forms of cities all over the world. These cities differ substantially in character and urban form and ...

  14. Nitrogen gas emissions from stormwater retention basins during wet weather events in the Phoenix Metropolitan area: an additional ecosystem service?

    E-Print Network [OSTI]

    Hall, Sharon J.

    . We pretreated the basin with a heavy N isotope (15N in NO3 ­ ) to trace the fate of the N added from any process by basin design. Data calculated from gas fluxes in chambers after water, but potentially producing considerable amounts of N2O, a greenhouse gas Incoming data will allow complete

  15. Intra-metropolitan health disparities in Canada: Studying how and why globalization matters, and what to do about it

    E-Print Network [OSTI]

    Schrecker, Ted

    2007-01-01T23:59:59.000Z

    Globalization and its Critics: Perspectives from Political Economy (globalization is defined as “a process of greater integration within the world economyeconomy or for specific sectors judged to be susceptible to the effects of globalization –

  16. Identification of Water Resources Planning Problems in the Metropolitan Area of Greater San Antonio and its Associated Counties

    E-Print Network [OSTI]

    Garner, J. K.; Shih, C. S.

    1973-01-01T23:59:59.000Z

    agencies, river authorities and interest groups in water resources management have evolved into a complicated system in this area. Thus, it was realized that an overview embedded with the systems approach for the current water resources problems is needed...

  17. Examining the Impact of Spatial Development Patterns on Regional Heat Island Effect in Metropolitan Regions of the United States

    E-Print Network [OSTI]

    Kim, Heeju

    2013-07-08T23:59:59.000Z

    The urban heat island effect is considered one of the main causes of global warming and is contributing to increasing temperatures in the urban United States. This phenomenon enhances the intensity of summer heat waves and the risk to public health...

  18. EV Community Readiness projects: Delaware Valley Regional Planning Commission (PA); Metropolitan Energy Information Center, Inc. (KS, MO)

    Broader source: Energy.gov [DOE]

    2013 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting

  19. The Boston Indicators Project : the role of indicators in supporting environmental efforts in the Boston metropolitan region

    E-Print Network [OSTI]

    Wells, Anna K. (Anna Katherine)

    2006-01-01T23:59:59.000Z

    Community indicators projects are an increasingly popular way to measure, track, and, advocates claim, make progress. The commonly held belief is that indicators provide residents, governments, private entities, and community ...

  20. Relationships between family disability and family interaction patterns: a metropolitan-nonmetropolitan comparison of southern black families.

    E-Print Network [OSTI]

    Taft, Earl Austin

    1973-01-01T23:59:59.000Z

    PELATTCL'"-", ITPS BETISE!I FAN L'i DISABXLIT" A". iD I"A'l~'! Y Xih'I'EH 'CTZG~I PATTE PIIS A IIETRCP~I TAX-i'iCi'u. '&I, ~BCPO' ' T-', i' COI'. PAI'TSOY: OF SO' 'THEPi; Bi '=CK F . "IL:E A Thesis EASEL AUSTZI'I T VT Tei':. 1s ' K "I ~:ivec... 24 CHAPTER V. METHODS Collection of Data Data Processing Concepts, Indicators, and Measures Family Disability 28 28 30 3- 3J Pa~e The Concept The Indicator The Measures Positional Location of Disabled Merr. hers The Concept...

  1. Access to jobs : transportation barriers faced by low-skilled autoless workers in U.S. metropolitan areas

    E-Print Network [OSTI]

    Kawabata, Mizuki, 1972-

    2002-01-01T23:59:59.000Z

    One of the major concerns in today's urban labor market is spatial mismatch, the geographic separation between jobs and workers. Although numerous studies examine spatial mismatch, most of them focus on inner-city minorities, ...

  2. Connecting Land Use and Transportation Toward Sustainable Development: A Case Study of Houston-Galveston Metropolitan Area

    E-Print Network [OSTI]

    Lee, Jae Su

    2011-02-22T23:59:59.000Z

    of sustainable development; rather it has been defined and applied according to the goals and objectives of each agent or organization (Beatley 1995; Litman and Burwell 2006). There is, however, a widely used concept of sustainable development defined...

  3. Identification of Management and Planning Problems of Urban Water Resources in the Metropolitan Area of Greater San Antonio

    E-Print Network [OSTI]

    Garner, K.; Shih, C. S.

    including the inventory and planning control for both surface and ground Water Resource Management of the San Antonio area are presented. Emphasis has been placed upon the identification of the probabilistic nature of various decision-making parameters...

  4. Energy cost reduction study of the Washington Metropolitan Area Transit Authority metrorail system. volume 2: appendices. Final report

    SciTech Connect (OSTI)

    Uher, R.A.; Sathi, N.; Sathi, A.

    1982-05-01T23:59:59.000Z

    This study is the first time that the Energy Management Model (EMM), developed for the transit industry by the Rail Systems Center at Carnegie-Mellon University, was comprehensively applied to a rapid transit property. The application to Metrorail was verified by comparing the simulated results to actual data obtained from the Potomac Electric Power Company (PEPCO). The simulated results agree to within 3 percent of the actual energy consumption. Five energy conservation strategies were recommended for implementation based on high benefit and low cost, namely: coasting, catch-up operation, passenger load factor improvement, regeneration of braking energy, and passenger station lighting improvements.

  5. A numerical reinvestigation of the Aoki phase with N_f=2 Wilson fermions at zero temperature

    E-Print Network [OSTI]

    Ilgenfritz, E M; Müller-Preussker, M; Sternbeck, A; Stüben, H

    2003-01-01T23:59:59.000Z

    We report on a numerical reinvestigation of the Aoki phase in lattice QCD with two flavors of Wilson fermions where the parity-flavor symmetry is spontaneously broken. For this purpose an explicitly symmetry-breaking source term $h\\bar{\\psi} i \\gamma_{5} \\tau^{3}\\psi$ was added to the fermion action. The order parameter $$ was computed with the Hybrid Monte Carlo algorithm at several values of $(\\beta,\\kappa,h)$ on lattices of sizes $4^4$ to $12^4$ and extrapolated to $h=0$. The existence of a parity-flavor breaking phase can be confirmed at $\\beta=4.0$ and $4.3,$ while we do not find parity-flavor breaking at $\\beta=4.6$ and 5.0.

  6. Vector and scalar form factors for K- and D-meson semileptonic decays from twisted mass fermions with Nf = 2

    E-Print Network [OSTI]

    S. Di Vita; B. Haas; F. Mescia; V. Lubicz; S. Simula; C. Tarantino

    2009-10-26T23:59:59.000Z

    We present lattice results for the form factors relevant in the K -> pion and D -> pion semileptonic decays, obtained from simulations with two flavors of dynamical twisted-mass fermions and pion masses as light as 260 MeV. For K -> pion decays we discuss the estimates of the main sources of systematic uncertainties, including the quenching of the strange quark, leading to our final result f+(0) = 0.9560 (57) (62). Combined with the latest experimental data, our value of f+(0) implies for the CKM matrix element |Vus| the value 0.2267 (5) (20) consistent with the first-row CKM unitarity. For D -> pion decays the application of Heavy Meson Chiral Perturbation Theory allows to extrapolate our results for both the scalar and the vector form factors at the physical point with quite good accuracy, obtaining a nice agreement with the experimental data. In particular at zero-momentum transfer we obtain f+(0) = 0.64 (5).

  7. Modulation of host NF-[k??a?p?p?a?]B pathway by the Toxoplasma gondii secreted factor, GRA15

    E-Print Network [OSTI]

    Lu, Diana, Ph. D. Massachusetts Institute of Technology

    2013-01-01T23:59:59.000Z

    The apicomplexan protozoan Toxoplasma gondii is an obligate intracellular pathogen that infects all warm blooded animals, including nearly thirty percent of the human population worldwide. Toxoplasma's success as a parasite ...

  8. On the Use of Thermal NF3 as the Fluorination and Oxidation Agent in Treatment of Used Nuclear Fuels

    SciTech Connect (OSTI)

    Scheele, Randall D.; McNamara, Bruce K.; Casella, Andrew M.; Kozelisky, Anne E.

    2012-05-01T23:59:59.000Z

    This paper presents results of our investigation on the use of nitrogen trifluoride as the fluorination or fluorination/oxidation agent for use in a process for separating valuable constituents from used nuclear fuels by employing the volatility of many transition metal and actinide fluorides. Nitrogen trifluoride is less chemically and reactively hazardous than the hazardous and aggressive fluorinating agents used to prepare uranium hexafluoride and considered for fluoride volatility based nuclear fuels reprocessing. In addition, nitrogen trifluoride’s less aggressive character may be used to separate the volatile fluorides from used fuel and from themselves based on the fluorination reaction’s temperature sensitivity (thermal tunability) rather than relying on differences in sublimation/boiling temperature and sorbents. Our thermodynamic calculations found that nitrogen trifluoride has the potential to produce volatile fission product and actinide fluorides from candidate oxides and metals. Our simultaneous thermogravimetric and differential thermal analyses found that the oxides of lanthanum, cerium, rhodium, and plutonium fluorinated but did not form volatile fluorides and that depending on temperature volatile fluorides formed from the oxides of niobium, molybdenum, ruthenium, tellurium, uranium, and neptunium. We also demonstrated near-quantitative removal of uranium from plutonium in a mixed oxide.

  9. Studies of resonantly produced plasmas in the H-1NF heliac using a far-infrared scanning interferometer

    E-Print Network [OSTI]

    Howard, John

    with an electric motor to provide a stable computer controlled rotational speed and to make the system acoustically and the other as a vibration monitor to compensate for wheel induced vibrations. With the grating wheel rotating and signal to noise ratio. We typically choose N 30. A Fourier shifting algorithm is used to correct

  10. QCD thermodynamics with $N_f=2+1$ near the continuum limit at realistic quark masses

    E-Print Network [OSTI]

    Takashi Umeda

    2006-10-03T23:59:59.000Z

    We report on our study of QCD thermodynamics with 2+1 flavors of dynamical quarks. In this proceeding we present several thermodynamic quantities and our recent calculation of the critical temperature. In order to investigate the thermodynamic properties of QCD near the continuum limit we adopt improved staggered (p4) quarks coupled with tree-level Symanzik improved glue on $N_t=4$ and 6 lattices. The simulations are performed with a physical value of the strange quark mass and light quark masses which are in the range of $m_q/m_s=0.05-0.4$. The lightest quark mass corresponds to a pion mass of about 150 MeV.

  11. I kappa B epsilon provides negative feedback to control NF-kappa B oscillations, signaling dynamics, and inflammatory gene expression

    E-Print Network [OSTI]

    Kearns, Jeffrey D; Basak, Soumen; Werner, Shannon L; Huang, Christine S; Hoffmann, Alexander

    2006-01-01T23:59:59.000Z

    Cancer Lett. 206: 193-199. Hoffmann, A. , and D. Baltimore.Immunol. Rev. 210:171-186. Hoffmann, A. , A. Levchenko, M.L.Science. 298:1241—1245. Hoffmann, A. , T.H. Leung, and D.

  12. P105 and p100 proteins function as the core of heterogeneous NF-kappaB complexes

    E-Print Network [OSTI]

    Savinova, Olga V.

    2009-01-01T23:59:59.000Z

    the p105 mutant protein that lacks a death domain, p105(1-and p105 mutant protein that lacks the C-terminal deaththat YFP-tagged p105 proteins that lack the ANK domain are

  13. I kappa B epsilon provides negative feedback to control NF-kappa B oscillations, signaling dynamics, and inflammatory gene expression

    E-Print Network [OSTI]

    Kearns, Jeffrey D; Basak, Soumen; Werner, Shannon L; Huang, Christine S; Hoffmann, Alexander

    2006-01-01T23:59:59.000Z

    Immunol. 174:983—991. Emmerich, F. , S. Theurich, M. Hummel,Spiecker et al. , 2000; Emmerich et al. , 2003; Doerre etSpiecker et al. , 2000; Emmerich et al. , 2003; Doerre et

  14. ineralization of acid and sweet whey. There would be about 150 000200 000 m2 of NF

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    properties [13]. In crossflow filtration of whey using organic membranes, the most important fouling to fouling. Some studies have demonstrated that the hydrodynamic operating conditions of mem- brane crossflow

  15. A R T I C L E p53 stabilization is decreased upon NF B activation: A role for

    E-Print Network [OSTI]

    Wahl, Geoffrey M.

    et al., 1995). Since transcrip-et al., 1996), and hypoxia (Graeber et al., 1994), lead to activation

  16. MODULATION OF THE NF-KAPPA B SIGNALING PATHWAY BY THE BACTERIAL TYPE III SECRETION SYSTEM EFFECTORS

    E-Print Network [OSTI]

    Gao, Xiaofei

    2012-08-31T23:59:59.000Z

    The type III secretion system (T3SS) is a bacterial injection system expressed by many Gram-negative bacteria. During the last two decades, the repertoire of T3SS effectors has been greatly explored, and several mechanisms ...

  17. Nucleon form factors and structure functions with N_f=2+1 dynamical domain wall fermions

    E-Print Network [OSTI]

    RBC-UKQCD Collaborations; :; Takeshi Yamazaki; Shigemi Ohta

    2007-10-02T23:59:59.000Z

    We report isovector form factors and low moments of structure functions of nucleon in numerical lattice quantum chromodynamics (QCD) from the on-going calculations by the RIKEN-BNL-Columbia (RBC) and UKQCD Collaborations with (2+1) dynamical flavors of domain-wall fermion (DWF) quarks. We calculate the matrix elements with four light quark masses, corresponding to pion mass values of m_\\pi = 330-670 MeV, while the dynamical strange mass is fixed at a value close to physical, on (2.7 fm)^3 spatial volume. We found that our axial charge, g_A, at the lightest mass exhibits a large deviation from the heavier mass results. This deviation seems to be a finite-size effect as the g_A value scales with a single parameter, m_\\pi L, the product of pion mass and linear spatial lattice size. The scaling is also seen in earlier 2-flavor dynamical DWF and Wilson quark calculations. Without this lightest point, the three heavier mass results show only very mild mass dependence and linearly extrapolate to g_A=1.16(6). We determined the four form factors, the vector (Dirac), induced tensor (Pauli), axial vector and induced pseudoscalar, at a few finite momentum transfer values as well. At the physical pion mass the form-factors root mean square radii determined from the momentum-transfer dependence %of the form factors are 20-30% smaller than the corresonding experiments. The ratio of the isovector quark momentum to helicity fractions, _{u-d}/_{\\Delta u - \\Delta d} is in agreement with experiment without much mass dependence including the lightest point. We obtain an estimate, 0.81(2), by a constant fit. Although the individual momentum and helicity fractions are yet to be renormalized, they show encouraging trend toward experiment.

  18. Functions of receptor activator of NF-?B ligand (RANKL) and its receptors, RANK and OPG, are evolutionarily conserved 

    E-Print Network [OSTI]

    Sutton, Kate Maurice

    2014-11-28T23:59:59.000Z

    The tumour necrosis factor (TNF) superfamily is a group of cytokines that orchestrate a variety of functions, both in the development of the architecture of immune organs and of the immune response. The mammalian TNF ...

  19. DETEW!INATION OF THE NEUTRON MAGNETIC FlONENT G.L. Greene and N.F. Ramsey

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power Administration wouldDECOMPOSITION OF CALCIUM SULFATE: A REVIEW OF THEDETEW!INATION OF THE

  20. Essays on Urban Transportation and Transportation Energy Policy

    E-Print Network [OSTI]

    Kim, Chun Kon

    2008-01-01T23:59:59.000Z

    energy use and compare the results for city or metropolitan areaenergy consumption as we have seen in previous literature at city or metropolitan area

  1. ANNUAL REPORT ALAN M.VOORHEES

    E-Print Network [OSTI]

    , including the development of planned cities such as Columbia, MD and Canberra,Australia, and metropolitan

  2. Abstract--Developing clear, relevant performance measures for arterials is challenging due to complicated traffic control

    E-Print Network [OSTI]

    Bertini, Robert L.

    to develop freeway performance measures [5]. The Tri-County Metropolitan Transportation District (Tri

  3. Atmos. Chem. Phys., 10, 53715389, 2010 www.atmos-chem-phys.net/10/5371/2010/

    E-Print Network [OSTI]

    Meskhidze, Nicholas

    % prompt and 30% slow evapora- tion) at a site northwest from the metropolitan area (PEMEX Correspondence

  4. Investigations of Atmospheric and Plant Physiological Effects along an Urban-To-Rural Gradient in the Houston Metropolitan Area Comparing 2011 to 2012 

    E-Print Network [OSTI]

    Gramann, Jonathan

    2014-09-02T23:59:59.000Z

    of oak trees near each weather station were measured on periodic field trips throughout the growing season. Comparisons of temperature, rainfall, carbon dioxide, and ozone concentrations indicate that urbanization is a possible but imperfect proxy...

  5. Opportunity-Rich Schools and Sustainable Communities: Seven Steps to Align High-Quality Education with Innovations in City and Metropolitan Planning and Development

    E-Print Network [OSTI]

    McKoy, Deborah; Vincent, Jeffrey M; Bierbaum, Ariel H

    2011-01-01T23:59:59.000Z

    their region. ” Living Cities also created the Sustainableto develop sustainable communities. Living Cities recognizes

  6. Effects of urban land cover modifications in a mesoscale meteorological model on surface temperature and heat fluxes in the Phoenix metropolitan area.

    E-Print Network [OSTI]

    Hall, Sharon J.

    in the modeling domain was calculated as part of the energy balance equation according to: E = a C CuM[qs(Tg) -qs MM5. The single urban category in the existing 25-category United States Geological Survey (USGS surface energy fluxes and ground temperature. Planetary boundary layer processes were included via the MRF

  7. Assessment of the Applicability of Cooperative Vehicle-Highway Automation Systems to Bus Transit and Intermodal Freight: Case Study Feasibility Analyses in the Metropolitan Chicago Region

    E-Print Network [OSTI]

    2004-01-01T23:59:59.000Z

    it is a form of vehicle automation that could be implementedare developed. For full automation, vehicle-roadway wirelessof Cooperative Vehicle-Highway Automation Systems to Bus

  8. Manchester Metropolitan University Actions arising from Chair of ADC's AME Report to Academic Board on the findings of the 2010/11 Annual Monitoring Exercise

    E-Print Network [OSTI]

    with a live improvement process that is fit for purpose. CASQE DVCs PMI 2011/12 High 2. Issues highlighted MMUnion, DVC (SE) CASQE PMI CASQE Faculty and Campus SAS, PMI 2011/12 2011/12 2011/12 2011/12 2011/12 High and Campus SAS, PMI 2011/12 High 3. Matters of institutional significance (Trends and/or generic themes

  9. BROOKINGS-ROCKEFELLER Project on State and Metropolitan Innovation State Clean Energy Finance Banks: New Investment Facilities for Clean Energy Deployment

    E-Print Network [OSTI]

    Ken Berlin; Reed Hundt; Mark Muro; Devashree Saha

    “?The creation of state clean energy banks represents another arena for state leadership on alternative energy finance.” Summary Propelled by private entrepreneurship, technology gains, and public support, clean energy and energy efficiency solutions began to proliferate in recent years. However, federal policy gridlock and state budget challenges are now jeopardizing the availability of government finance, exacerbating the serious finance challenges that impede the large-scale deployment of low-carbon energy solutions. Fortunately a number of states are now exploring a variety of ways to leverage scarce public resources with sophisticated banking and finance mechanisms. Epitomized by Connecticut’s

  10. Emerging factors associated with the decline of a gray fox population and multi-scale land cover associations of mesopredators in the Chicago metropolitan area.

    SciTech Connect (OSTI)

    Willingham, Alison N.; /Ohio State U.; ,

    2008-01-01T23:59:59.000Z

    Statewide surveys of furbearers in Illinois indicate gray (Urocyon cinereoargenteus) and red (Vulpes vulpes) foxes have experienced substantial declines in relative abundance, whereas other species such as raccoons (Procyon lotor) and coyotes (Canis latrans) have exhibited dramatic increases during the same time period. The cause of the declines of gray and red foxes has not been identified, and the current status of gray foxes remains uncertain. Therefore, I conducted a large-scale predator survey and tracked radiocollared gray foxes from 2004 to 2007 in order to determine the distribution, survival, cause-specific mortality sources and land cover associations of gray foxes in an urbanized region of northeastern Illinois, and examined the relationships between the occurrence of gray fox and the presence other species of mesopredators, specifically coyotes and raccoons. Although generalist mesopredators are common and can reach high densities in many urban areas their urban ecology is poorly understood due to their secretive nature and wariness of humans. Understanding how mesopredators utilize urbanized landscapes can be useful in the management and control of disease outbreaks, mitigation of nuisance wildlife issues, and gaining insight into how mesopredators shape wildlife communities in highly fragmented areas. I examined habitat associations of raccoons, opossums (Didelphis virginiana), domestic cats (Felis catus), coyotes, foxes (gray and red), and striped skunks (Mephitis mephitis) at multiple spatial scales in an urban environment. Gray fox occurrence was rare and widely dispersed, and survival estimates were similar to other studies. Gray fox occurrence was negatively associated with natural and semi-natural land cover types. Fox home range size increased with increasing urban development suggesting that foxes may be negatively influenced by urbanization. Gray fox occurrence was not associated with coyote or raccoon presence. However, spatial avoidance and mortality due to coyote predation was documented and disease was a major mortality source for foxes. The declining relative abundance of gray fox in Illinois is likely a result of a combination of factors. Assessment of habitat associations indicated that urban mesopredators, particularly coyotes and foxes, perceived the landscape as relatively homogeneous and that urban mesopredators interacted with the environment at scales larger than that accommodated by remnant habitat patches. Coyote and fox presence was found to be associated with a high degree of urban development at large and intermediate spatial scales. However, at a small spatial scale fox presence was associated with high density urban land cover whereas coyote presence was associated with urban development with increased forest cover. Urban habitats can offer a diversity of prey items and anthropogenic resources and natural land cover could offer coyotes daytime resting opportunities in urban areas where they may not be as tolerated as smaller foxes. Raccoons and opossums were found to utilize moderately developed landscapes with interspersed natural and semi-natural land covers at a large spatial scale, which may facilitate dispersal movements. At intermediate and small spatial scales, both species were found to utilize areas that were moderately developed and included forested land cover. These results indicated that raccoons and opossums used natural areas in proximity to anthropogenic resources. At a large spatial scale, skunk presence was associated with highly developed landscapes with interspersed natural and semi-natural land covers. This may indicate that skunks perceived the urban matrix as more homogeneous than raccoons or opossums. At an intermediate spatial scale skunks were associated with moderate levels of development and increased forest cover, which indicated that they might utilize natural land cover in proximity to human-dominated land cover. At the smallest spatial scale skunk presence was associated with forested land cover surrounded by a suburban matrix. Compared to raccoon

  11. Investigations of Atmospheric and Plant Physiological Effects along an Urban-To-Rural Gradient in the Houston Metropolitan Area Comparing 2011 to 2012

    E-Print Network [OSTI]

    Gramann, Jonathan

    2014-09-02T23:59:59.000Z

    Township”) is a master-planned community started in 1974 and currently covering 115 km2 with a population of over 100,000 residents and a median household income over $100,000 [US Census Bureau 2012]. As the name indicates, The Woodlands is a heavily... wooded area. According to their official website, "the Woodlands philosophy even encourages ‘natural yards’ with less grass and more forest" [The Woodlands Township 2014]. The weather station is located behind the 5 school in an area characteristic...

  12. Investigation of surface inhomogeneity and estimation of the GOES skin temperature assimilation errors of the MM5 implied by the inhomogeneity over Houston metropolitan area

    E-Print Network [OSTI]

    Han, Sang-Ok

    2005-11-01T23:59:59.000Z

    This study developed a parameterization method to investigate the impacts of inhomogeneous land surfaces on mesoscale model simulations using a high-resolution 1-d PBL model. Then, the 1-d PBL model was used to investigate the inhomogeneity...

  13. Evaluation of the volatility basis-set approach for the simulation of organic aerosol formation in the Mexico City metropolitan area

    E-Print Network [OSTI]

    Tsimpidi, A. P.

    New primary and secondary organic aerosol modules have been added to PMCAMx, a three dimensional chemical transport model (CTM), for use with the SAPRC99 chemistry mechanism based on recent smog chamber studies. The new ...

  14. /7 soF'/t,,,,n,re D toPm NT". Using a Co nf=guration Management Tool to CoordInate

    E-Print Network [OSTI]

    Grinter, Rebecca Elizabeth

    for coordination they provide, and their role in supporting a model of work. KEYWORDS: configuration management (CM of coordinating group work. This particular technology, a configuration management (CM) tool, incorporates begins with a description of configuration management, and how it involves coordinating the work

  15. Form factors of the $D \\to ?$ and $D \\to K$ semileptonic decays with $N_f = 2$ twisted mass lattice QCD

    E-Print Network [OSTI]

    S. Di Vita; B. Haas; V. Lubicz; F. Mescia; S. Simula; C. Tarantino; for the ETM Collaboration

    2011-04-05T23:59:59.000Z

    We present lattice results for the vector and scalar form factors of the semileptonic decays D -> \\pi \\ell \

  16. Regulation of cytochrome P450 3A4 gene expression through modulating pregnane X receptor transcriptional activity by NF-? aryl hydrocarbon receptor and xenobiotics 

    E-Print Network [OSTI]

    Gu, Xinsheng

    2009-05-15T23:59:59.000Z

    Cytochrome P450 3A4 (CYP3A4) is a key enzyme responsible for the metabolism of drugs and endogenous compounds in human liver and intestine. CYP3A4 gene expression is mainly regulated by Pregnane X receptor (PXR) which is a ligand-dependent nuclear...

  17. Distinct NF-kB activation pathways engaged by T-cell receptor and co-receptor CD28 on T-cells

    E-Print Network [OSTI]

    Thaker, Youg Raj; Rudd, Christopher E

    2015-03-02T23:59:59.000Z

    at the pro-T3 stage [16]. In addition to this, Jurkat T-cell mutant lines lacking either SLP-76 or LAT expression showed a vital requirement of both molecules in mediating TCR-induced PLC?1 phosphorylation, extracellular signal-regulated kinase (ERK...

  18. DU145 human prostate cancer cells express functional Receptor Activator of NF-B: New insights in the prostate cancer bone metastasis process.

    E-Print Network [OSTI]

    Boyer, Edmond

    in the prostate cancer bone metastasis process. Mori K.1, 2, * , Le Goff B. 1, 2 , Charrier C. 1, 2 , Battaglia S cells, thus facilitating prostate cancer metastasis development in bone. We confirm that RANKL is a factor that facilitates metastasis to bone by acting as an activator of both osteoclasts and RANK

  19. Regulation of cytochrome P450 3A4 gene expression through modulating pregnane X receptor transcriptional activity by NF-? aryl hydrocarbon receptor and xenobiotics

    E-Print Network [OSTI]

    Gu, Xinsheng

    2009-05-15T23:59:59.000Z

    by biotransformation alters its biological effects, not only its pharmacokinetic behavior. In the case of pharmacology, some drugs must undergo biotransformation to exert their pharmacodynamic effect. In the case of toxicology, many xenobiotics must undergo...

  20. port reduces NF to 3.76 dB, which is in good agreement with the noise figure predicted without circuit losses at 5.8 GHz.

    E-Print Network [OSTI]

    Jerby, Eli

    monolithic low noise amplifier for wireless applications at 5 GHz, 1996 IEEE MMMICs Dig, pp 81­84. 9. I and procedures utilized to design an amplifier that can simultaneously provide high-gain, low-power consumption amplifier for low cost 1.5­8 GHz commercial applications, 1993 IEEE MMICS Dig, pp 13­16. 6. K.R. Gioffi

  1. TWIST1 associates with NF-kappaB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 production

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    subunit RELA via carboxyl-terminal WR domain to promote cellthrough the TWIST1 carboxy-terminal WR (Trp-Arg) domainis dependent on the C- terminal WR domain, through which

  2. Stimulation of Fas (CD95) induces production of pro-inflammatory mediators through ERK/JNK-dependent activation of NF-jB in THP-1 cells

    E-Print Network [OSTI]

    Lee, Won-Ha

    Stimulation of Fas (CD95) induces production of pro-inflammatory mediators through ERK line THP-1 (which expresses both Fas and FasL) was stimulated through treatment with agonistic anti in macrophage function, the human macrophage-like cell line THP-1 was analyzed after treatment with agonistic

  3. Three-gluon running coupling from lattice QCD at $N_f=2+1+1$: a consistency check of the OPE approach

    E-Print Network [OSTI]

    Ph. Boucaud; M. Brinet; F. De Soto; V. Morenas; O. Pène; K. Petrov; J. Rodríguez-Quintero

    2014-01-31T23:59:59.000Z

    We present a lattice calculation of the renormalized running coupling constant in symmetric (MOM) and asymmetric ($\\widetilde{\\rm MOM}$) momentum substraction schemes including $u$, $d$, $s$ and $c$ quarks in the sea. An Operator Product Expansion dominated by the dimension-two $\\langle A^2\\rangle$ condensate is used to fit the running of the coupling. We argue that the agreement in the predicted $\\langle A^2\\rangle$ condensate for both schemes is a strong support for the validity of the OPE approach and the effect of this non-gauge invariant condensate over the running of the strong coupling.

  4. 15-Deoxy-?{sup 12,14}-prostaglandin J{sub 2} inhibits IL-13 production in T cells via an NF-?B-dependent mechanism

    SciTech Connect (OSTI)

    Doyle, Marie-Christine; Tremblay, Sarah [Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke (QC), Canada J1K 2R1 (Canada)] [Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke (QC), Canada J1K 2R1 (Canada); Dumais, Nancy, E-mail: nancy.dumais@usherbrooke.ca [Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke (QC), Canada J1K 2R1 (Canada)] [Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke (QC), Canada J1K 2R1 (Canada)

    2013-02-15T23:59:59.000Z

    Highlights: ? 15d-PGJ{sub 2} decreased IL-13 mRNA transcription and secretion in activated T cells. ? IL-13 inhibition by 15d-PGJ{sub 2} is independent of PPAR-?. ? The nuclear factor-?B mediates the 15d-PGJ{sub 2}-dependent down regulation of IL-13. -- Abstract: Interleukin (IL)-13 is a cytokine produced by activated CD4{sup +} T cells that plays a critical role in promoting allergic responses and tumor cell growth. The 15-deoxy-?{sup 12,14}-prostaglandin J{sub 2} (15d-PGJ{sub 2}) is a natural ligand for the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-?), a known regulator of anti-inflammatory activities. We determined the effects of 15d-PGJ{sub 2} on IL-13 expression in the Jurkat E6.1 T-cell line and in peripheral blood mononuclear cells. Semi-quantitative reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay revealed that treatment of activated T cells with 15d-PGJ{sub 2} significantly decreased IL-13 mRNA transcription and secretion, respectively. This inhibition by 15d-PGJ{sub 2} was independent of PPAR-? since treatment with GW9662, an irreversible antagonist of the nuclear receptor, produced no effect. Our data also revealed the involvement of nuclear factor-?B in mediating 15d-PGJ{sub 2}-dependent down regulation of IL-13 expression. Collectively, these results demonstrate the potential of 15d-PGJ{sub 2} in attenuating expression and production of IL-13 in activated T cells.

  5. D O M A I NF A L L 2 0 0 4 55555 How a Top Secret Satellite and Fast-Thinking

    E-Print Network [OSTI]

    Weathermen Saved the Apollo 11 Astronauts from Disaster I t was one of those turning points in history where his "one small step for man," and the Apollo 11 Moon landers were speed ing back towards Earth-thinking weathermen -- Navy CAPT Willard "Sam" Houston and Air Force Maj. Hank Brandli. Saving Apollo 11Saving Apollo

  6. Deregulation of the phosphatidylinositol-3 kinase signaling cascade is associated with neurodegeneration in Npc1-/- mouse brain.

    E-Print Network [OSTI]

    Bi, Xiaoning; Liu, Jihua; Yao, Yueqin; Baudry, Michel; Lynch, Gary

    2005-01-01T23:59:59.000Z

    Inherited Diseases Deregulation of the Phosphatidylinositol-tion, and for NF- ? B deregulation; moreover, these changes3 ? Is Associated with Deregulation of NF- ? B Accumulating

  7. PORTLAND STATE UNIVERSITY CENTER FOR TRANSPORTATION STUDIES

    E-Print Network [OSTI]

    Bertini, Robert L.

    PORTLAND STATE UNIVERSITY CENTER FOR TRANSPORTATION STUDIES DEPARTMENT OF CIVIL & ENVIRONMENTAL ENGINEERING SCHOOL OF URBAN STUDIES AND PLANNING First Annual Portland Metropolitan Region Transportation System Performance Report September 8, 2004 #12;2First Annual Portland Metropolitan Region Transportation

  8. Love, Purification, and Forgiveness versus Justice, Punishment, and Satisfaction: The Debates on Purgatory and the Forgiveness of Sins

    E-Print Network [OSTI]

    Lasenby, Joan

    ' the Greeks to accept their doctrines.5 However, the refusal of Mark Eugenicus, Metropolitan of Ephesus,6

  9. Size-resolved aerosol emission factors and new particle formation/growth activity occurring in Mexico City during the MILAGRO 2006 Campaign

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    wind and air pollution interaction in the Mexico Basin,2006). The air pollution in the Mexico City Metropolitan

  10. The Determinants of Attitudes towards Strategic Default on Mortgages

    E-Print Network [OSTI]

    their house in the Salinas, CA metropolitan statistical area (MSA) in 2006 was -$214,305.2 Unfortunately, we

  11. NIFES Consulting Group, NIFES House, Sinderland Road, Broadheath, Altrincham, Cheshire, WA14 5HQ Tel: 0161 928 5791 | Fax: 0161 926 8718| www.nifes.co.uk

    E-Print Network [OSTI]

    .elkin@nifes.co.uk Ref: UKE1520 Manchester Metropolitan University Energy Audit/SE Date: January 2009 Status: R1,860 5.8 #12;UKE1520 Manchester Metropolitan University 2 Energy Audit Renewable technologies were also.0 COMMERCIAL IN CONFIDENCE REPORT for MANCHESTER METROPOLITAN UNIVERSITY for an ENERGY SURVEY at ALL SAINTS

  12. Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NF{kappa}B and AhR and EGFR-ERK pathway

    SciTech Connect (OSTI)

    Potapovich, Alla I. [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy); Biology Department, Belarus State University, Skorina Prosp. 10, Minsk 220050 (Belarus); Lulli, Daniela; Fidanza, Paolo [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy); Kostyuk, Vladimir A. [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy); Biology Department, Belarus State University, Skorina Prosp. 10, Minsk 220050 (Belarus); De Luca, Chiara; Pastore, Saveria [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy); Korkina, Liudmila G., E-mail: l.korkina@idi.it [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy)

    2011-09-01T23:59:59.000Z

    Molecular mechanisms underlying modulation of inflammatory responses in primary human keratinocytes by plant polyphenols (PPs), namely the glycosylated phenylpropanoid verbascoside, the stilbenoid resveratrol and its glycoside polydatin, and the flavonoid quercetin and its glycoside rutin were evaluated. As non-lethal stimuli, the prototypic ligand for epidermal growth factor receptor (EGFR) transforming growth factor alpha (TGFalpha), the combination of tumor necrosis factor (TNFalpha) and interferon (IFNgamma) (T/I), UVA + UVB irradiation, and bacterial lipopolysaccharide (LPS) were used. We demonstrated differential modulation of inflammatory responses in keratinocytes at signal transduction, gene transcription, and protein synthesis levels as a function of PP chemical structure, the pro-inflammatory trigger used, and PP interaction with intracellular detoxifying systems. The PPs remarkably inhibited constitutive, LPS- and T/I-induced but not TGFalpha-induced ERK phosphorylation. They also suppressed NFkappaB activation by LPS and T/I. Verbascoside and quercetin invariably impaired EGFR phosphorylation and UV-associated aryl hydrocarbon receptor (AhR)-mediated signaling, while rutin, polydatin and resveratrol did not affect EGFR phosphorylation and further activated AhR machinery in UV-exposed keratinocytes. In general, PPs down-regulated gene expression of pro-inflammatory cytokines/enzymes, except significant up-regulation of IL-8 observed under stimulation with TGFalpha. Both spontaneous and T/I-induced release of IL-8 and IP-10 was suppressed, although 50 {mu}M resveratrol and polydatin up-regulated IL-8. At this concentration, resveratrol activated both gene expression and de novo synthesis of IL-8 and AhR-mediated mechanisms were involved. We conclude that PPs differentially modulate the inflammatory response of human keratinocytes through distinct signal transduction pathways, including AhR and EGFR. - Graphical abstract: Display Omitted Highlights: > Effects of plant polyphenols on inflammatory responses in human keratinocytes. > Inflammatory stimuli used: TGFalpha, TNFalpha+IFNgamma, UVA+UVB, and LPS. > Inflammatory pathways connected with NFB, ERK1/2, EGFR, and AhR were investigated. > Plant polyphenols, flavonoids, stilbenoids, and phenylpropanoids, were studied. > Modulation of inflammation depends on phenolic core structure and glycosylation.

  13. High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53 - NF-kappaB - complex-dependent gene expression in human heart failure

    E-Print Network [OSTI]

    Choy, Mun-Kit; Movassagh, Mehregan; Siggens, Lee; Vujic, Ana; Goddard, Martin; Sanchez, Ana; Perkins, Neil; Figg, Nichola; Bennett, Martin; Carroll, Jason; Foo, Roger S-Y

    2010-06-14T23:59:59.000Z

    00.5 1 1.5 2 miR-15b miR-21 miR-125b -Dox +Dox Additional file 2 (Choy, et al) 40 30 20 1 0 mir-15b mir-21 mir-125b Dox control m iR N A a bu nd an ce [a rb ita ry u ni ts ] 0 0.02 0.04 0.06 0.08 1 2 normoxia hypoxia 30 0 6 90 CF m iR -2 1 ab un... da nc e [a rb ita ry u ni ts ] Hypoxia - + WB: p53 WB: SF2 DFX - -+ + Nuc Cyt WB: p53 WB: SF2 WB: RhoGDI A B C Dox - + WB: p53 WB: SF2 * * ...

  14. Supplementary Fig. 1. Inhibition of TLR2-induced NF-B activation by TirS is comparable to inhibition mediated by DN-hMyD88 or addition of a TLR2 antagonist SSL3. Untreated control

    E-Print Network [OSTI]

    Nizet, Victor

    to inhibition mediated by DN-hMyD88 or addition of a TLR2 antagonist SSL3. Untreated control cells were

  15. antibodies targeting cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of an NF-B responsive element (pNF-B- Luc) encapsulated in a PRb peptide functionalized stealth targeted systems. In addition, we constructed a novel cancer therapeutic plasmid...

  16. akt phosphorylation sites: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ser-142 (14). Ser-129 is believed to be a substrate for glycogen synthase kinase 3 Brownfield, Mark S. 36 Mass spectrometric analysis of bovine neurofilament proteins NF-L, NF-M,...

  17. Transit\tUse\tand\tCarpooling 7D Land\tUse\tManagement\tand\tUrban...

    Broader source: Energy.gov (indexed) [DOE]

    Metropolitan Planning Organization (Metro) undertook a literature re- view and case studies to quantify the effects of various TDM strategies. Summary results appear in...

  18. Massachusetts Clean Air Act (Massachusetts)

    Broader source: Energy.gov [DOE]

    The Act contains regulations to prevent the pollution and contamination of the atmosphere. The Act establishes a contiguous metropolitan pollution control district, comprised of towns in the...

  19. Better Buildings Neighborhood Program Workforce Peer Exchange...

    Energy Savers [EERE]

    NHCDFA Kansas City: Jensen Adams and Warren Adams Leavitt, Metropolitan Energy Center * Discussion: What types of mentoring or continued training have newly trained...

  20. Characterization of Aerosols Containing Zn, Pb, and Cl from an...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the March, 2006 MILAGRO campaign, measurements in the Northern Mexico City Metropolitan Area revealed the frequent appearance of particles with a characteristically high content of...

  1. Land use regulation and intraregional population-employment interaction

    E-Print Network [OSTI]

    Kim, JH; Hewings, GJD

    2013-01-01T23:59:59.000Z

    Levine J (2006) Zoned out: Regulation, markets, and choicesprices, externalities, and regulation in U.S. metropolitanCT (2000) Land use regulation and new construction. Regional

  2. A Blueprint for Urban Sustainability: Integrating Sustainable...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    A Blueprint for Urban Sustainability: Integrating Sustainable Energy Practices into Metropolitan Planning, May 2004 A Blueprint for Urban Sustainability: Integrating Sustainable...

  3. Disastrous Response to Natural and Man-Made Disasters: An Environmental Justice Analysis Twenty-Five Years after Warren County

    E-Print Network [OSTI]

    Bullard, Robert D.; Wright, Beverly

    2008-01-01T23:59:59.000Z

    of 149) metropolitan areas with hazardous waste sites (70%)concentrated in areas with com- mercial hazardous sites thanhazardous waste facilities, nearly doubling the percentage in areas

  4. area pollution sources: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    unless Rodney B. W. Smith; Theodore D. Tomasi 63 Impact of primary formaldehyde on air pollution in the Mexico City Metropolitan Area MIT - DSpace Summary: Formaldehyde (HCHO)...

  5. aires city region: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    urban-to-regional scale air Odman, M. Talat 43 Impact of primary formaldehyde on air pollution in the Mexico City Metropolitan Area MIT - DSpace Summary: Formaldehyde (HCHO)...

  6. air pollutants area: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4 Technology and policy options for reducing industrial air pollutants in the Mexico City Metropolitan Area MIT - DSpace Summary: Technology plays an important role in...

  7. area heavily polluted: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of (more) Enohnyaket, John 2013-01-01 18 Impact of primary formaldehyde on air pollution in the Mexico City Metropolitan Area MIT - DSpace Summary: Formaldehyde (HCHO)...

  8. area southern mexico: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    public domain British Columbia (l; R. H. Pinsent 5 Impact of primary formaldehyde on air pollution in the Mexico City Metropolitan Area MIT - DSpace Summary: Formaldehyde (HCHO)...

  9. area nellis air: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    reduction credits (offsets); Tuan Ngo P. E 39 Impact of primary formaldehyde on air pollution in the Mexico City Metropolitan Area MIT - DSpace Summary: Formaldehyde (HCHO)...

  10. area pollution advisory: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Semrau; Joe Simmler; Jane Zimmerman 2005-01-01 17 Impact of primary formaldehyde on air pollution in the Mexico City Metropolitan Area MIT - DSpace Summary: Formaldehyde (HCHO)...

  11. CX-002677: Categorical Exclusion Determination | Department of...

    Broader source: Energy.gov (indexed) [DOE]

    in Torrance, California. The station will be located along the existing 17 mile long hydrogen pipeline that runs through the Torrance and Wilmington areas of metropolitan Los...

  12. Workplace Charging Challenge Partner: Washington Area New Automobile...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Association (WANADA) serves as the representative organization for all franchised new car dealers in the metropolitan Washington region. Workplace charging matches the vision...

  13. Multi-Channel and Multi-Rate Adaptation for High-Throughput Wireless Networks

    E-Print Network [OSTI]

    Nguyen, Duy Duc

    2012-01-01T23:59:59.000Z

    layer. Unlike wired networks, wireless networks have to deal2 Background Wireless Networks Wireless technology is allWLAN), wireless mesh networks, wireless metropolitan area

  14. ashkenazi jewish woman: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ashkenazi Jewish genetic disease carrier screening and genetic counseling in the New York metropolitan area that have a Jewish genetic component Provide rabbis and other...

  15. Green Buildings in Green Cities: Integrating Energy Efficiency into the Real Estate Industry

    E-Print Network [OSTI]

    Bardhan, Ashok; Kroll, Cynthia A.

    2011-01-01T23:59:59.000Z

    2008. Shrinking the Carbon Footprint of Metropolitan US. TheUnited States. Their carbon footprint is significant. Thecompanywide (worldwide) carbon footprint, at the other end

  16. Department of Electrical and Electronic Engineering updated on July 25, 2011 MSc Courses for Undergraduate Students as Depth Courses (2011-2012)

    E-Print Network [OSTI]

    Leung, Ka-Cheong

    for metropolitan cities 2 6 ELEC6095 Smart Grid 2 6 ELEC6602 Business Venture in China 2 6 X X X X ELEC7144

  17. Suburban Poverty: Barriers to Services and Injury Prevention among Marginalized Women Who Use Methamphetamine

    E-Print Network [OSTI]

    Boeri, Miriam W.; Tyndall, Benjamin D; Woodall, Denise R

    2011-01-01T23:59:59.000Z

    and the suburbanization of poverty. The Metropolitan Policyriginal R esearch Suburban Poverty: Barriers to Services andmarginalized by drug use and poverty in order to prevent

  18. aquatic plants water: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    within the metropolitan area of Oklahoma City US Army Corps of Engineers 114 North City Water Reclamation Plant Energy Storage, Conversion and Utilization Websites Summary:...

  19. The New Suburbs: Evolving travel behavior, the built environment, and subway investments in Mexico City

    E-Print Network [OSTI]

    Guerra, Erick

    2013-01-01T23:59:59.000Z

    infrastructure and Census shapefiles from the Nationalin the metropolitan area. Shapefiles from 2005 were directlyIn order to generate shapefiles for 1990, I used INEGI’s

  20. The New Suburbs: Evolving travel behavior, the built environment, and subway investment in Mexico City

    E-Print Network [OSTI]

    Guerra, Erick Strom

    2013-01-01T23:59:59.000Z

    infrastructure and Census shapefiles from the Nationalin the metropolitan area. Shapefiles from 2005 were directlyIn order to generate shapefiles for 1990, I used INEGI’s

  1. academic health sciences: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    is a vital force in the Las Vegas metropolitan area, educating desperately needed health care professionals and taking on some Cho, Hokwon 12 and Occupational Health...

  2. academic health science: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    is a vital force in the Las Vegas metropolitan area, educating desperately needed health care professionals and taking on some Cho, Hokwon 12 and Occupational Health...

  3. Socioeconomic Differences in Household Automobile Ownership Rates: Implications for Evacuation Policy

    E-Print Network [OSTI]

    Raphael, S; Berube, A; Deakin, Elizabeth

    2006-01-01T23:59:59.000Z

    Differences in 10 Household Automobile Ownership Rates:hauseltoldr lacking automobiles were mmit like! ) to be leftWithout 3 Access to an Automobile. Top Ten Metropolitan

  4. This document was prepared as part of the Alternative Fuel Implementation Team project, sponsored by the U.S. Department of Energy's Clean Cities program. The U.S. Government nor any agency thereof, assumes any legal liability or responsibility for the

    E-Print Network [OSTI]

    Fuel Tool Kit Case Study on Biodiesel: Metropolitan Sewerage District Introduction Metropolitan a total of 113 on road vehicles, 59 of which use biodiesel. These 59 vehicles span light, medium of off-road construction equipment (e.g. backhoes, loaders, earth compactors) utilize biodiesel. The 91

  5. Modeling Transit Trip Time Using Archived Bus Dispatch System Data

    E-Print Network [OSTI]

    Bertini, Robert L.

    Transportation District of Oregon TriMet provides transit service in the three-county Portland metropolitan area that are automatically collected and archived for each bus, route, and stop every day. The Tri-County Metropolitan. TriMet has implemented a Bus Dispatch System BDS as a part of its overall service control

  6. Empirical findings of Bus Bunching Distributions and Attributes Using Archived AVL/APC Bus Data

    E-Print Network [OSTI]

    Bertini, Robert L.

    performance. This study is motivated by the low performance of a route operated by Portland Tri-County of data for TriMet's Route 15. TriMet is the transit provider for the Portland, Oregon metropolitan region Metropolitan Transportation District of Oregon (TriMet). The goals of this research are to: (1) identify

  7. The Interpretation of N+N and V+N Compounds by Spanish Heritage Speakers

    E-Print Network [OSTI]

    Gonzalez, Patricia Garza

    2014-09-19T23:59:59.000Z

    .4 Implications of the Laredo-Nuevo Laredo Metropolitan Area demographics ..................................................................................................... 18 1.5 Heritage language speakers: A linguistic characterization... and the Laredo-Nuevo Laredo Metropolitan Area. Most importantly, this section provides an overview of the profile of bilingual heritage language speakers in the United States. It discusses the linguistic characterization of bilingual heritage speakers...

  8. E-Print Network 3.0 - ankyrin-repeat membrane protein Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    10 Stabilizing IB by "Consensus" Design Diego U. Ferreiro1,3 Summary: Keywords: protein folding; ankyrin repeat protein; NF-B; transcription factor; repeat protein...

  9. E-Print Network 3.0 - ankyrin protein networks Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    >> 21 Stabilizing IB by "Consensus" Design Diego U. Ferreiro1,3 Summary: Keywords: protein folding; ankyrin repeat protein; NF-B; transcription factor; repeat protein...

  10. Garden Patch Chili

    E-Print Network [OSTI]

    ... 17-ounce can corn kernels, drained Toppings of your choice (salsa, chopped red onions, chopped cilantro, nf yogurt, [avocado, cheese], etc.) 1. Drain beans.

  11. PROTON BEAM REQUIREMENTS FOR A NEUTRINO FACTORY AND MUON COLLIDER

    E-Print Network [OSTI]

    Zisman, Michael S.

    2010-01-01T23:59:59.000Z

    Table 1 summarizes the NF proton driver parameters obtainedboth facilities. Table 1. Proton driver requirements for arepetition frequency (Hz) Proton energy (GeV) Proton rms

  12. ITREOH building of regional capacity to monitor recreational water: Development of a non-commercial microcystin ELISA and its impact on public health policy

    E-Print Network [OSTI]

    2006-01-01T23:59:59.000Z

    International Center; Uruguay, Rio de la Plata; waterRepublica, Montevideo, Uruguay (BMB, LD, NF); the Laboratoryof Montev- ideo, Uruguay (BMB, DS); the National Direction

  13. Insights into the homeostatic regulation of I kappa B alpha

    E-Print Network [OSTI]

    Lisabeth, Erika Mathes

    2009-01-01T23:59:59.000Z

    Biol, 13, 1572-1582. Emmerich, F. , Meiser, M. , Hummel,fully inhibit NF-?B (Emmerich et al. , 1999; Jungnickel et

  14. amniotic membrane graft: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    by grafting of Engineering Websites Summary: of polyamide thin-film composite membranes. The structure of nanofiltration (NF) and reverse osmosis (RO.V. All rights...

  15. advanced membrane filtration: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    available reverse osmosis (RO) and nanofiltration (NF) membranes are based on the thin film composite (TFC) aromatic polyamide membranes. However, they have several disadvantages...

  16. Control of size and charge selectivity in amphiphilic graft copolymer nanofiltration membranes

    E-Print Network [OSTI]

    Lovell, Nathan Gary

    2010-01-01T23:59:59.000Z

    The throughput and efficiency of membrane separations make polymer filtration membranes an important resource for the pharmaceutical, food and wastewater treatment industries. Nanofiltration (NF) membranes fill an important ...

  17. Anti-inflammatory and anti-oxidative effects of corilagin in a rat model of acute cholestasis

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    MPO), malondialdehyde (MDA), superoxide dismutase (SOD) andintervention, levels of MPO, MDA and translocation of NF-?BMPO), malondialdehyde (MDA), super- oxide dismutase (SOD),

  18. air-stable planar chiral: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in QCD. One of the predictions of orientifold planar equivalence is that the chiral condensates of a theory with Nf flavours of Dirac fermions in the symmetric (or...

  19. Optimal receiver cost and wavelength number minimization in all-optical ring networks

    E-Print Network [OSTI]

    Boyer, Edmond

    one of these equipments and explain how to reduce the CAPEX of such networks by properly dimensioning project aims to reduce the CAPital EXpen- diture (CAPEX) of metropolitan networks with low ecological

  20. Ahmet H. Aydilek, 1 Tuncer B. Edil, 1 Patrick J. Fox2 Consolidation Characteristics of Wastewater Sludge

    E-Print Network [OSTI]

    Aydilek, Ahmet

    Sludge ________________________________________________________________________ Reference: Aydilek, A. H., Edil, T. B., and Fox, P. J., "Consolidation Characteristics of Wastewater Sludge", Geotechnics of High contaminated sludge. The Madison Metropolitan Sewerage District evaluated different remediation alternatives

  1. Application of positive matrix factorization to on-road measurements for source apportionment of diesel- and gasoline-powered vehicle emissions in Mexico City

    E-Print Network [OSTI]

    Thornhill, D. A.

    The goal of this research is to quantify diesel- and gasoline-powered motor vehicle emissions within the Mexico City Metropolitan Area (MCMA) using on-road measurements captured by a mobile laboratory combined with positive ...

  2. Flexible urbanism

    E-Print Network [OSTI]

    Anandam, Anahita

    2006-01-01T23:59:59.000Z

    This thesis seeks to find a new approach/method towards urbanization in existing low density neighborhoods in major metropolitan cities in the United States. The near South side of the city of Chicago (a city that carries ...

  3. Sustainability Assessment of Residential Building Energy System in Belgrade

    E-Print Network [OSTI]

    Vucicevic, B.; Bakic, V.; Jovanovic, M.; Turanjanin, V.

    2010-01-01T23:59:59.000Z

    As a metropolitan city, Belgrade is a dwelling place for about 25% of total citizen number of Republic of Serbia, and at the same time regional cultural, educational, scientific and business center with its own energy production. Belgrade represents...

  4. Characterization of submicron aerosols at a rural site in Pearl River Delta of China using an Aerodyne High-Resolution Aerosol Mass Spectrometer

    E-Print Network [OSTI]

    Kroll, Jesse

    The Pearl River Delta (PRD) region in South China is one of the most economically developed regions in China, but it is also noted for its severe air pollution due to industrial/metropolitan emissions. In order to continuously ...

  5. EnergyWorks KC's Training Programs Provide Job Opportunities...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    EnergyWorks KC has trained 208 workers and placed 91 in green jobs in the Kansas City area. Successes include the Metropolitan Energy Center's training for professions such...

  6. Ozone response to emission changes: a modeling study during the MCMA-2006/MILAGRO Campaign

    E-Print Network [OSTI]

    Song, Jihee

    The sensitivity of ozone production to precursor emissions was investigated under five different meteorological conditions in the Mexico City Metropolitan Area (MCMA) during the MCMA-2006/MILAGRO field campaign using the ...

  7. Hit from both sides: tracking industrial and volcanic plumes in Mexico City with surface measurements and OMI SO2 retrievals during the MILAGRO field campaign

    E-Print Network [OSTI]

    de Foy, B.

    Large sulfur dioxide plumes were measured in the Mexico City Metropolitan Area (MCMA) during the MILAGRO field campaign. This paper seeks to identify the sources of these plumes and the meteorological processes that affect ...

  8. Modeling the impacts of biomass burning on air quality in and around Mexico City

    E-Print Network [OSTI]

    Lei, W.

    The local and regional impacts of open fires and trash burning on ground-level ozone (O[subscript 3]) and fine carbonaceous aerosols in the Mexico City Metropolitan Area (MCMA) and surrounding region during two high fire ...

  9. Contribution of garbage burning to chloride and PM[subscript 2.5] in Mexico City

    E-Print Network [OSTI]

    Li, G.

    The contribution of garbage burning (GB) emissions to chloride and PM[subscript 2.5] in the Mexico City Metropolitan Area (MCMA) has been investigated for the period of 24 to 29 March during the MILAGRO-2006 campaign using ...

  10. Northern noble savages? Edward Daniel Clarke and British primitivist narratives on Scotland and Scandinavia, c.1760-1822 

    E-Print Network [OSTI]

    Andersson Burnett, Linda Carin Cecilia; Burnett, Linda Carin Cecilia Andersson

    2012-06-28T23:59:59.000Z

    This thesis analyses a growing metropolitan British fascination with northern Scandinavia and Scotland towards the end of the eighteenth century. These two northern regions underwent a dramatic transformation, from being ...

  11. CX-004443: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    State Energy Program - Combined Heat and Power - Metropolitan CouncilCX(s) Applied: B5.1Date: 11/16/2010Location(s): MinnesotaOffice(s): Energy Efficiency and Renewable Energy, Golden Field Office

  12. Projections, politics, and practice in regional planning : a case study of MetroFuture

    E-Print Network [OSTI]

    Paul, Evan Thomas

    2010-01-01T23:59:59.000Z

    This thesis describes the comprehensive planning effort undertaken by the Metropolitan Area Planning Council in the Boston area. This effort engaged over 4,000 of the area's residents between 2002 and 2009 and produced a ...

  13. Assessment of the potential diversion of air passengers to high-speed rail in the northeast corridor

    E-Print Network [OSTI]

    Clarke, Michael D. D.

    1994-01-01T23:59:59.000Z

    The high level of intercity passenger travel in the Northeast Corridor is supported by densely populated metropolitan city-centers, the suitable distance between the urban areas, and the extent to which economic and social ...

  14. Undergraduate Internship Program -National Clandestine Service

    E-Print Network [OSTI]

    Meyers, Steven D.

    Undergraduate Internship Program - National Clandestine Service Work Schedule: Full Time Salary: $39,752 Location: Washington, DC metropolitan area Applications for internships starting in Summer arm of the CIA. The NCS Undergraduate Internship Program offers a limited number of talented

  15. Land development approaches in the context of land scarcity : case study, Byblos, Lebanon

    E-Print Network [OSTI]

    Asdourian, Avedis

    1986-01-01T23:59:59.000Z

    The objective of this study is to provide a general understanding for guiding urban development in secondary cities in Lebanon. An existing site in the Byblos Metropolitan Area is utilized as a reference to this study. The ...

  16. Short Bio of Naomi Angel Naomi Angel, Architect, M.Sc.

    E-Print Network [OSTI]

    Sadeh, Norman M.

    Planner (one of 6 Districts in Israel). Primary projects: Metropolitan Comprehensive Plan, Business in Public Uses ­ guide and & Directives High-rise Buildings - Planning Directives 2004 Urban Design Planning bureau consists of 25 professionals: Architects, Planners, Specific advisors ­ assessment

  17. archaeological site lammasmgi: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ARCHAEOLOGICAL WOODS FROM TERRESTRIAL SITES.E., (EDS.), PP. 328-347. THE METROPOLITAN MUSEUM OF ART, NEW YORK. 12;R.A. BLANCHETTE 329 ABSTRACT Wood Blanchette, Robert A. 9...

  18. archaeological site necochea: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ARCHAEOLOGICAL WOODS FROM TERRESTRIAL SITES.E., (EDS.), PP. 328-347. THE METROPOLITAN MUSEUM OF ART, NEW YORK. 12;R.A. BLANCHETTE 329 ABSTRACT Wood Blanchette, Robert A. 9...

  19. archaeological sites: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ARCHAEOLOGICAL WOODS FROM TERRESTRIAL SITES.E., (EDS.), PP. 328-347. THE METROPOLITAN MUSEUM OF ART, NEW YORK. 12;R.A. BLANCHETTE 329 ABSTRACT Wood Blanchette, Robert A. 9...

  20. Residential property values and neighborhood retail : a comparison of pedestrian and automobile oriented retail clusters

    E-Print Network [OSTI]

    Tiffany, Thacher

    2006-01-01T23:59:59.000Z

    This study tests the hypothesis that home buyers pay a premium to live within walking distance of pedestrian accessible retail. To answer this question two types of retail clusters are identified in the Boston metropolitan ...

  1. Optimal Urban Population Size: National vs Local Economic Efficiency

    E-Print Network [OSTI]

    Nam, Kyung-min

    This paper explores whether the population size of the Seoul Metropolitan Area (SMA) in Korea is efficient in terms of the national economy. To undertake this analysis, a recursively dynamic interregional computable general ...

  2. SCREENING OF FRENCH MINING EXPLOITATIONS: A METHODOLOGY AND A NATIONAL HIERARCHISATION TO EVALUATE THE GEOTECHNICAL RISK

    E-Print Network [OSTI]

    Boyer, Edmond

    (concessions, exploration agreements) have been granted throughout the whole metropolitan French territory ore basins exploited in France : certain metal mines (copper in Alps, uranium in Centre-West, etc

  3. Oxidative capacity of the Mexico City atmosphere - Part 1: A radical source perspective

    E-Print Network [OSTI]

    Volkamer, R.

    A detailed analysis of OH, HO2 [HO subscript 2] and RO2 [RO subscript 2] radical sources is presented for the near field photochemical regime inside the Mexico City Metropolitan Area (MCMA). During spring of 2003 (MCMA-2003 ...

  4. Applications of Engineering and Financial Analysis to the Valuation of Investments in Railroad Infrastructure 

    E-Print Network [OSTI]

    Roco, Craig E.

    2010-01-16T23:59:59.000Z

    to legislative proposals to relocate hazardous materials transported by rail around metropolitan areas. A risk analysis model was developed to predict the risk of exposure from the release of a hazardous material following a train derailment so that changes...

  5. Ozone production rate and hydrocarbon reactivity in 5 urban areas: A cause of high ozone concentration in Houston

    E-Print Network [OSTI]

    petrochemical complexes in the world. As a consequence the concentration of O3 in the Houston metropolitan area from nearby petrochemical facili- ties. A comparison between Houston and 4 other cities (Nashville, TN

  6. Atmos. Chem. Phys., 14, 70757089, 2014 www.atmos-chem-phys.net/14/7075/2014/

    E-Print Network [OSTI]

    Pierce, Jeffrey

    ), the Johannesburg­Pretoria metropolitan conurbation (> 10 mil- lion people), the Vaal Triangle (e.g. petrochemical and petrochemical industry) and also a region of anticyclonic recirculation of air mass over the in- terior of South

  7. Vehicle Technologies Office Merit Review 2014: Mid-America Collaborative for Alternative Fuels Implementation

    Broader source: Energy.gov [DOE]

    Presentation given by Metropolitan Energy Center, Inc. at 2014 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Office Annual Merit Review and Peer Evaluation Meeting about Mid-America...

  8. Measurements of the chemical, physical, and optical properties of single aerosol particles

    E-Print Network [OSTI]

    Moffet, Ryan Christopher

    2007-01-01T23:59:59.000Z

    particulate matter (PM) pollution in Mexico City, one needsuse Mexico City as a case study of air pollution mitigationMexico City Metropolitan area (MCMA) have employed a variety of instrumentation to address particulate pollution

  9. air reduce migratory: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2011-01-01 17 Technology and policy options for reducing industrial air pollutants in the Mexico City Metropolitan Area MIT - DSpace Summary: Technology plays an important role in...

  10. DOEE A-1059 Environmental Assessment Radioactive Source Recovery...

    Broader source: Energy.gov (indexed) [DOE]

    Alamos County are remote from major metropolitan areas and major sources of industrial pollution. In 1992, a i r quality at LANL was much better than ambient air quality...

  11. Finding the missing stratospheric Bry: a global modeling study of CHBr3 and CH2Br2

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    and dispersion of a Mexico City pollution out- flow eventon air pollution in the Mexico City Metropolitan Area,pollution transport during the MILAGRO-2006 campaign: a case study of a major Mexico

  12. Composition, sources, and formation of secondary organic aerosols from urban emissions

    E-Print Network [OSTI]

    Liu, Shang; Liu, Shang

    2012-01-01T23:59:59.000Z

    City, Mexico; Bakersfield, US), urban pollution-influencedthe Mexico City basin, suggesting that the air pollution notMexico City Metropolitan Area (MCMA) is the second largest megacity in the world. Although its pollution

  13. Detailed comparisons of airborne formaldehyde measurements with box models during the 2006 INTEX-B and MILAGRO campaigns: potential evidence for significant impacts of unmeasured and multi-generation volatile organic carbon compounds

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    on Air Pollution in the Mexico City Metropolitan Area, 9,and transport of pollution over the Gulf of Mexico and thepollution to sustain the production of ozone and SOA already in the chemical near field over Mexico

  14. SeptemberOctober 2003 Westernite Page 1www.westernite.org

    E-Print Network [OSTI]

    Bertini, Robert L.

    of the project include the Tri-County Metropolitan Transportation District (TriMet), the Oregon Department of Transportation (ODOT), and the City of Portland. TriMet provides transit service with more than 600 buses along

  15. Using Archived AVL/APC Bus Data to Identify Spatial-Temporal1 Causes of Bus Bunching2

    E-Print Network [OSTI]

    Bertini, Robert L.

    performance of a route operated by17 Portland Tri-County Metropolitan Transportation District of Oregon (Tri-year's worth of data for TriMet's Route 15. TriMet is the transit provider for the Portland,11 Oregon

  16. PORTLAND STATE UNIVERSITY CENTER FOR TRANSPORTATION STUDIES

    E-Print Network [OSTI]

    Bertini, Robert L.

    PORTLAND STATE UNIVERSITY CENTER FOR TRANSPORTATION STUDIES DEPARTMENT OF CIVIL & ENVIRONMENTAL Transportation System Performance Report December 27, 2005 #12;2Second Annual Portland Metropolitan Region Transportation System Performance Report Portland State University Center for Transportation Studies 2005

  17. 11.380J / 1.252J / ESD.225J Urban Transportation Planning, Fall 2002

    E-Print Network [OSTI]

    Salvucci, Frederick

    This class is an introduction to planning transportation in metropolitan areas. The approach, while rooted on the analytical tools which estimate outcomes and alternatives, is holistic. This means starting from ...

  18. If you reside in WASHINGTON, DC - MD -VA - WV your salary will...

    National Nuclear Security Administration (NNSA)

    If you are employed in the WASHINGTON, DC Metropolitan Area (D.C., Baltimore, Northern VA, Eastern WV, and Southern PA) your salary will range from: Pay Band Pay Plan(s) Minimum...

  19. Economic costs of conventional surface-water treatment: A case study of the Mcallen northwest facility 

    E-Print Network [OSTI]

    Rogers, Callie Sue

    2009-05-15T23:59:59.000Z

    Conventional water treatment facilities are the norm for producing potable water for U.S. metropolitan areas. Rapidly-growing urban populations, competing demands for water, imperfect water markets, and uncertainty of future water supplies...

  20. Copy right:Must ask the author to use this template Tolessa Deksissa (tdeksissa@udc.edu), July 31, 2008www.udc.edu/wrri

    E-Print Network [OSTI]

    District of Columbia, University of the

    Copy right:Must ask the author to use this template Tolessa Deksissa (tdeksissa@udc.edu), July 31 quality data in the metropolitan Washington, D.C. area, as reported by the U.S. Geological Survey (USGS

  1. Rhetorical Response to the Homeless Movement: Adopting Discursive Units in Counter-Frames

    E-Print Network [OSTI]

    Mathe, Kristin S.

    2010-07-14T23:59:59.000Z

    in the public discussions about homelessness published in the St. Petersburg Times, in Pinellas County, Florida. This county is representative of other metropolitan regions that experienced rapid growth, gentrification, and are now seeing skyrocketing rates...

  2. Laboratory characterization of a highly weathered old alluvium in San Juan, Puerto Rico

    E-Print Network [OSTI]

    Zhang, Guoping, 1968-

    2002-01-01T23:59:59.000Z

    The old alluvium underlying much of metropolitan San Juan was formed in early Pleistocene and has undergone substantial post-depositional weathering in the tropical climate of Puerto Rico, resulting in a special combination ...

  3. Intelligent Transportation Systems: Saving Lives, Time and Money Kristin Tufte

    E-Print Network [OSTI]

    Bertini, Robert L.

    Intelligent Transportation Systems: Saving Lives, Time and Money Kristin Tufte Portland State University Oregon Transportation Summit Sept 10, 2010 #12;Intelligent Transportation Systems: Saving Lives, Time and Money Official transportation data archive for the Portland-Vancouver metropolitan region

  4. Preliminary Release: April 19, 2012

    U.S. Energy Information Administration (EIA) Indexed Site

    "Not in metropolitan or micropolitan" "statistical area",2.8,3.1,3.3,"Q" "Climate Region4" "Very ColdCold",21.6,25.1,27.7,21.5 "Mixed-Humid","N","N","N","N"...

  5. Preliminary Release: April 19, 2012

    U.S. Energy Information Administration (EIA) Indexed Site

    "Not in metropolitan or micropolitan" "statistical area",9.6,8.6,8.5,7.5 "Climate Region4" "Very ColdCold","Q","Q","Q","Q" "Mixed-Humid",52.1,56.4,55.8,54...

  6. The U.S. Department of Energy's Brookhaven National Laboratory P.O. Box 5000, Upton NY 11973 631 344-2345 www.bnl.gov Homeland Security

    E-Print Network [OSTI]

    engineering infrastructure such as mass transit systems, electric power, gas/oil distribution and communication networks, as well as social infrastructure like housing, business, and news networks, and natural York Metropolitan Region: Counterterrorism and Infrastructure Assurance Technology Needs," co

  7. Game theory and real options : analysis of land value and strategic decisions in real estate development

    E-Print Network [OSTI]

    So, Chun Kit (Chun Kit Timothy)

    2013-01-01T23:59:59.000Z

    This thesis investigates the use of the game theory and the real options theory in real estate development at the strategic level, trying empirically to explain different economic observations among different metropolitan ...

  8. Key worker housing : a demand analysis of middle-income workforce housing in eastern Massachusetts

    E-Print Network [OSTI]

    Sacks, Sean D

    2005-01-01T23:59:59.000Z

    The Boston Metropolitan Area is one of the most expensive places to live in the United States. In recent years studies have speculated that middle-income workers have had to endure increased commute times as they have moved ...

  9. Factor Prices in Egypt from 1900 to World War II with International Comparisons

    E-Print Network [OSTI]

    Hansen, Bent

    1989-01-01T23:59:59.000Z

    av. , Cigarette Laborers, industry Egypt: Metropolitan OtherBusiness: Rate of Profits Egypt and United States (percent)n. a. n .a. CG LO Rates, Egypt, Visible profit Rates, % of

  10. Income Inequality, Race, and Place:  Does the Distribution of Race and Class within Neighborhoods affect Crime Rates?

    E-Print Network [OSTI]

    Hipp, John R

    2007-01-01T23:59:59.000Z

    James W. 1990. "Ethnic Inequality and the Rate of Homicide."Blau. 1982. "The Cost of Inequality: Metropolitan StructureSociology 83:26-54. —. 1987. Inequality and Heterogeneity :

  11. Impact of the Miami 21's parking requirements on the real estate developments in the city of Miami

    E-Print Network [OSTI]

    Libman, Rafael

    2014-01-01T23:59:59.000Z

    In the last years, Fort Lauderdale, West Beach, and Miami together became the 8th largest metropolitan area in the U.S. with a population of approximately 6 million people. During the last four years the population of such ...

  12. Impacts of residential developments on local sustainability : case study in Metro Boston

    E-Print Network [OSTI]

    Xia, Jie, M.C.P. Massachusetts Institute of Technology

    2011-01-01T23:59:59.000Z

    Along with urbanization and decentralization, the sustainability of metropolitan areas is considered one of the most significant challenges worldwide. Transportation-related problems, such as congestion, GHG emissions, and ...

  13. A review of "New World, Known World: Shaping Knowledge in Early Anglo-American Writing." by David Read,

    E-Print Network [OSTI]

    Scheick, William J.

    2007-01-01T23:59:59.000Z

    the experiential realities of a community dependent upon and defined by economic success through trade. Morton?s New English Canaan applies a mercantile and metropolitan frame- work to familiarize New World experience for homeland readers. Morton indicts his...

  14. "For good design, you pay now; for bad design, you pay later"--or do you?

    E-Print Network [OSTI]

    Murugappan, Meena

    2006-01-01T23:59:59.000Z

    What is the value of architectural design on office building income? This empirical study of 296 office building located in 11 Metropolitan Statistical Areas (MSA) hopes to quantitatively determine if a plain vanilla cereal ...

  15. Aerosol plume transport and transformation in high spectral resolution lidar measurements and WRF-Flexpart simulations during the MILAGRO Field Campaign

    E-Print Network [OSTI]

    de Foy, B.

    The Mexico City Metropolitan Area (MCMA) experiences high loadings of atmospheric aerosols from anthropogenic sources, biomass burning and wind-blown dust. This paper uses a combination of measurements and numerical ...

  16. Measurements of OH and HO2 concentrations during the MCMA-2006 field campaign – Part 2: Model comparison and radical budget

    E-Print Network [OSTI]

    Dusanter, S.

    Measurements of hydroxyl (OH) and hydroperoxy (HO2) radicals were made during the Mexico City Metropolitan Area (MCMA) field campaign as part of the MILAGRO (Megacity Initiative: Local and Global Research Observations) ...

  17. Imagining Chivalry: Charles V's Suits of Steel

    E-Print Network [OSTI]

    Machado, Erin Jeannine

    2012-01-01T23:59:59.000Z

    Mail, German, 15 th century. Steel and brass. MetropolitanI. , Innsbruck, ca. 1512-14. Steel, gilded silver, velvet,Elector of Saxony, ca. 1555. Steel, copper alloy (brass),

  18. Emergence of Secondary Airports and Dynamics of Regional Airport Systems in the United States

    E-Print Network [OSTI]

    Bonnefoy, Philippe A

    2006-11-21T23:59:59.000Z

    With the growing demand for air transportation and limited capacity at major airports, there is a need to increase the capacity of airport systems at the metropolitan area level. The increased use of secondary airports has ...

  19. Emergence of secondary airports and dynamics of regional airport systems in the United States

    E-Print Network [OSTI]

    Bonnefoy, Philippe A

    2005-01-01T23:59:59.000Z

    With the growing demand for air transportation and limited capacity at major airports, there is a need to increase the capacity of airport systems at the metropolitan area level. The increased use of secondary airports has ...

  20. Urban Reclamation in São Paulo

    E-Print Network [OSTI]

    Eskinazi, Victor

    2009-01-01T23:59:59.000Z

    The urbanized terrain of São Paulo is characterized by wasteful landscapes on peripheral areas of the metropolitan agglomeration, and decaying landscapes of waste in the core of the city. If on the one hand, the increasingly ...

  1. Modeled and observed ozone sensitivity to mobile-source emissions in Mexico City

    E-Print Network [OSTI]

    Zavala, M.

    The emission characteristics of mobile sources in the Mexico City Metropolitan Area (MCMA) have changed significantly over the past few decades in response to emission control policies, advancements in vehicle technologies ...

  2. B O N N E V I L L E P O W E R A D M I N I S T R A T I O N

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The result could be blackouts. Growing power demands in this metropolitan area are driving the need for this line. Since BPA built the last major high-voltage line in the...

  3. Destination : a development plan or public space in the small historical town of Waxholm, Sweden

    E-Print Network [OSTI]

    Brockman, Peter M. (Peter Marik), 1962-

    1994-01-01T23:59:59.000Z

    Small towns offer a type of community different than that of large metropolitan areas. The ideals of this community are deeply rooted in its history and culture. However, the current state of small towns in general, not ...

  4. Sustainability Assessment of Residential Building Energy System in Belgrade 

    E-Print Network [OSTI]

    Vucicevic, B.; Bakic, V.; Jovanovic, M.; Turanjanin, V.

    2010-01-01T23:59:59.000Z

    As a metropolitan city, Belgrade is a dwelling place for about 25% of total citizen number of Republic of Serbia, and at the same time regional cultural, educational, scientific and business center with its own energy ...

  5. North City Water Reclamation Plant

    E-Print Network [OSTI]

    Prevedouros, Panos D.

    -Site Cogeneration Methane Power Plant Methane piped in from: Miramar LandfillMiramar Landfill Metropolitan Biosolids Covered Subgrade basins Malfunction in Point Loma South Bay North City Metro Biosolids Center WW Pumping

  6. antonio convention center: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Planning Problems of Urban Water Resources in the Metropolitan Area of Greater San Antonio Texas A&M University - TxSpace Summary: including the inventory and planning...

  7. aid resource planning: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Planning Problems of Urban Water Resources in the Metropolitan Area of Greater San Antonio Texas A&M University - TxSpace Summary: including the inventory and planning...

  8. antonio pereira district: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Planning Problems of Urban Water Resources in the Metropolitan Area of Greater San Antonio Texas A&M University - TxSpace Summary: including the inventory and planning...

  9. active water management: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Planning Problems of Urban Water Resources in the Metropolitan Area of Greater San Antonio Texas A&M University - TxSpace Summary: including the inventory and planning...

  10. agricultural water management: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Planning Problems of Urban Water Resources in the Metropolitan Area of Greater San Antonio Texas A&M University - TxSpace Summary: including the inventory and planning...

  11. MFR PAPER 1321 BOHDAN M. SLABYJ, DONN L. CREAMER, and RUTH H. TRUE

    E-Print Network [OSTI]

    -bushel quantities (27.2 kg) in plastic mesh bags and held immersed in the ocean on a raft for I or 2 days small market was re- tained supplying the demand of certain ethnic groups in metropolitan areas

  12. Evaluation of WRF mesoscale simulations and particle trajectory analysis for the MILAGRO field campaign

    E-Print Network [OSTI]

    de Foy, B.

    Accurate numerical simulations of the complex wind flows in the Mexico City Metropolitan Area (MCMA) can be an invaluable tool for interpreting the MILAGRO field campaign results. This paper uses three methods to evaluate ...

  13. Town of Airfield : creating a prototype for suburban development at the Naval Air Station site in South Weymouth

    E-Print Network [OSTI]

    Panfil, J. Christoph

    1996-01-01T23:59:59.000Z

    The accumulation of negative externalities associated with the rapid expansion of many metropolitan areas in the United States suggests that the current suburban development model is no longer a viable option for efficiently ...

  14. What happened to the three-decker?

    E-Print Network [OSTI]

    Wegmann, Jacob (Jacob G.)

    2006-01-01T23:59:59.000Z

    This thesis examines the three-decker, a type of small apartment house ("superposed flats") that is common in the Boston metropolitan region and elsewhere in New England. The three-decker is distinctive in two ways: its ...

  15. 11.001J / 4.250J Introduction to Urban Design and Development, Fall 2001

    E-Print Network [OSTI]

    Vale, Lawrence

    Examines the evolving structure of cities and the way that cities, suburbs, and metropolitan areas can be designed and developed. Guest speakers present cases, involving current projects, which illustrate the scope and ...

  16. West Virginia Business & Economic Review, Winter 2012 1 West Virginia

    E-Print Network [OSTI]

    Mohaghegh, Shahab

    Morgantown's prices. Utilities, which include electric, natural gas, and land-line telephone services, were 2 Metropolitan Area Composite Index (100%) Grocery Items (13%) Housing (29%) Utilities (10%) Transportation (9

  17. A study of illegal housing of Lisbon built in 1974 to 1984 : from description to computation

    E-Print Network [OSTI]

    Santos Romão, Luís António dos, 1958-

    2005-01-01T23:59:59.000Z

    A morphological description of illegal housing built by homeowners in the Metropolitan Area of Lisbon between 1974 and 1984 is presented. This description is based on a parametric set grammar that attempts to formulate ...

  18. Managing the implementation of automotive emission control technologies using systems engineering principles

    E-Print Network [OSTI]

    Penney, John, 1974-

    2004-01-01T23:59:59.000Z

    In the 1940s and 1950s poor air quality in major metropolitan areas throughout the United States started to negatively influence the health of citizens throughout the country. After numerous studies the government concluded ...

  19. CX-009364: Categorical Exclusion Determination

    Broader source: Energy.gov [DOE]

    DeKalb County/Metropolitan Atlanta Alternative Fuel and Advanced Technology Vehicle Project CX(s) Applied: A1, B5.1 Date: 09/19/2012 Location(s): Georgia Offices(s): National Energy Technology Laboratory

  20. An overview of the MILAGRO 2006 Campaign: Mexico City emissions and their transport and transformation

    E-Print Network [OSTI]

    Molina, Luisa Tan

    MILAGRO (Megacity Initiative: Local And Global Research Observations) is an international collaborative project to examine the behavior and the export of atmospheric emissions from a megacity. The Mexico City Metropolitan ...

  1. Ozone predictabilities due to meteorological uncertainties in the Mexico City basin using ensemble forecasts

    E-Print Network [OSTI]

    Bei, Naifang

    The purpose of the present study is to investigate the sensitivity of ozone (O3)[(O subscript 3)] predictions in the Mexico City Metropolitan Area (MCMA) to meteorological initial uncertainties and planetary boundary layer ...

  2. Does Schooling Contribute to Increase Individuals Chances to Access The More Affluent Income Groups?

    E-Print Network [OSTI]

    Ortega, Esther Ruiz

    , 2001). The work covers both positive and policy issues, but its central focus is on the role to education and gender for wage-earners in Greater Córdoba, a typical mid-size metropolitan area in Argentina

  3. The Houston Lightning Mapping Array: Network Installation and Preliminary Analysis

    E-Print Network [OSTI]

    Cullen, Matthew Ryan

    2013-06-25T23:59:59.000Z

    The Houston Lightning Mapping Array (LMA) is a lightning detection network providing total lightning mapping for the Houston metropolitan area and southeast Texas. The network is comprised of twelve Very High Frequency (VHF) time-of-arrival total...

  4. Computing Needs Time Edward A. Lee

    E-Print Network [OSTI]

    (CSR-CPS)), the U. S. Army Research Office (ARO #W911NF-07-2-0019), the U. S. Air Force Office essential prop- erties of the physical systems, most particularly the passage of time. It makes a case (CSR-CPS)), the U. S. Army Research Office (ARO #W911NF-07-2-0019), the U. S. Air Force Office

  5. MEETING ABSTRACT Open Access Predominant role of Tax sumoylation in

    E-Print Network [OSTI]

    Boyer, Edmond

    the NF-kB pathway by acting both at cytoplasmic and nuclear levels. In the cytoplasm, Tax binds to and activates the IkB Kinase (IKK) complex while in the nucleus, Tax assembles tran- scriptional active nuclear bodies. Others and we have previously demonstrated that the cytoplasmic/nuclear partition and NF

  6. Relating Interactions between Neurofilaments to the Structure of Axonal Neurofilament Distributions through Polymer Brush Models

    E-Print Network [OSTI]

    Kumar, Sanjay

    ; Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195 with the experimental observation that sidearm phosphor- ylation regulates interfilament spacing. The presence-L, 61 kDa in humans), medium (NF-M, 90 kDa), and heavy (NF-H, 110 kDa) (Lee and Cleveland, 1996

  7. Increasing Cancer-Specific Gene Expression by Targeting Overexpressed 51 Integrin and Upregulated Transcriptional

    E-Print Network [OSTI]

    Kokkoli, Efie

    Engineering and Materials Science, University of Minnesota, 421 Washington Ave SE, Minneapolis, Minnesota the control of an NF-B responsive element (pNF-B- Luc) encapsulated in a PR_b peptide functionalized stealth was seen when transfected with PR_b functionalized stealth liposomes encapsulating the condensed p

  8. Dr. Pete's useful stuff College Physics I*

    E-Print Network [OSTI]

    Nelson, Peter Hugo

    /nelson Hooke's Law & SHM Friction NfNf kkss µµ = kineticstatic Gravitation Quadratic functions ax2 + bx + c = 0 Momentum im= = p v P p rr rr Conservation laws for an isolated system i f i fE E P P= = simple pendulum k g

  9. Reason for Testing (Required-failure to include a diagnosis may delay testing. Include all pertinent diagnoses and ICD9 codes. Ie. Primary Lung Cancer 162.9 with metastasis to brain 198.3 and bone 198.5)

    E-Print Network [OSTI]

    Wang, David

    , NF1, NOTCH1, NPM1, NRAS, PDGFRA, PIK3CA, PTCH1, PTEN, PTPN11, RB1, RET, RUNX1, SMO, STK11, TET2, TP53 MAP2K2 MET MPL MTOR MYC MYD88 NF1 NOTCH1 NPM1 NRAS PDGFRA PIK3CA PTCH1 PTEN PTPN11 RB1 RET RUNX1 SMO

  10. TEA: Automatically proving termination of programs in a nonstrict higherorder functional

    E-Print Network [OSTI]

    Schmidt-Schauss, Manfred

    TEA: Automatically proving termination of programs in a non­strict higher­order functional language termination of functions written in a non­strict high­level functional programming language like Haskell kinds of termination: nf­termination and lazy termination. Intuitively, nf­termination of f means

  11. Quadratic and differential forms over function fields of Pfister quadrics in characteristic two*

    E-Print Network [OSTI]

    @inst-mat.utalca.cl Abstract Let F be a field of characteristic 2. Let nFbe the F-space of differ- ential + nV a db, then let nF= 1Fand d : nF ! n+1Fbe the differential operato

  12. The BMM Global-Local bijection for GL(n,q) fhm rinivsn

    E-Print Network [OSTI]

    Srinivasan, Bhama

    prtition of nF heorem @pongErinivsnA D re in the sme `Elok if nd only if D hve the sme eEoreF Bhama of nF heorem @pongErinivsnA D re in the sme `Elok if nd only if D hve the sme eEoreF Bhama Srinivasan

  13. ENEA F. Zonca 1 Multiple space-time structure of low-frequency fluctuations in

    E-Print Network [OSTI]

    Zonca, Fulvio

    techniques based on scale separation. 2 BF introduced by a number of authors in the late 70's (Coppi PRL77, Lee PFBW 77, Glasser PFBW 77, Pegoraro IAEA 78, Connor PRL 78, Dewar NF81) to conveniently treat (Coppi PRL77, Lee PFBW 77, Glasser PFBW 77, Pegoraro IAEA 78, Connor PRL 78, Dewar NF81) to conveniently

  14. A novel derivative of decursin, CSL-32, blocks migration and production of inflammatory mediators and modulates PI3K

    E-Print Network [OSTI]

    Lee, Won-Ha

    and Biotechnology, Kyungpook National University, Daegu 702-701, Korea { College of Pharmacy, Chungnam NationalB), phosphorylation of p65 subunit of NF-kB (nuclear factor-kB) and nuclear translocation of NF-kB, which are required

  15. Dmarche qualit au sein d'un laboratoire de recherche du CNRS: FEMTO-ST

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    également lancés dans la mise en place de la norme NF EN ISO 9001 afin d'obtenir une certification : recherche, qualité, laboratoires, label Carnot, ISO 9001, ISO/CEI 17025, Université de Franche-Comté, FEMTO décennies des laboratoires accrédités par le COFRAC selon le référentiel NF EN ISO/CEI 17025. Ainsi, le

  16. Neurofilament Proteins in Avian Auditory Hair Cells

    E-Print Network [OSTI]

    Rubel, Edwin

    Neurofilament Proteins in Avian Auditory Hair Cells ELIZABETH C. OESTERLE,* DIANA I. LURIE avian inner ear by using immunocytochemical techniques. NF-M was detected in auditory hair cells and VIIIth cranial nerve neurons. NF-M-positive hair cells are first detected at embryonic day 11 (E11

  17. ASPECTS OF PARTIAL INFORMATION IN DATABASES Leonid Libkin

    E-Print Network [OSTI]

    Libkin, Leonid

    {c7 38. Kg4{f5 Nf6:d5+ 13. h2{h3? Bc8{d7 39. Kf5{g4 Nd5{f6+ 14. Rb1{c1 g7{g6 40. Kg4{f5 Nf6{g8+ 15. Nf3{d2 Ra8{b8 41. Kf5{g4 Ng8{f6+ 16. Nd2{b3 Nc5:b3 42. Kg4{f5 Nf6{g8+ 17. Qc2:b3 c6{c5 43. Kf5{g4 Be7:g5 18. Kg1{h2 Kg8{h8 44. Kg4:g5 Rf8{f7 19. Qb3{c2 Nf6{g8 45. Bf2{h4 Rh6{g6+ 20. Be2{g4 Ng8{h6 46. Kg

  18. Influence of the Torsion Angle in 3,3'-Dimethyl-2,2'-bipyridine on the Intermediate Valence of Yb in (C5Me5)2 Yb(3,3'-Me2-bipy)

    SciTech Connect (OSTI)

    Nocton, Gr& #233; gory; Booth, Corwin H.; Maron, Laurent; Andersen, Richard A.

    2014-06-26T23:59:59.000Z

    The synthesis and X-ray crystal structures of Cp-2*Yb(3,3'-Me(2)bipy) and [Cp-2 Yb(3,3'-Me(2)bipy)][Cp-2 YbCl1.6I0.4]center dot CH2Cl2 are described. In both complexes, the NCCN torsion angles are approximately 40 degrees. The temperature-independent value of n(f) of 0.17 shows that the valence of ytterbium in the neutral adduct is multiconfigurational, in reasonable agreement with a CASSCF calculation that yields a n(f) value of 0.27; that is, the two configurations in the wave function are f(13)(pi(1))(1) and f(14)(pi(1))(0) in a ratio of 0.27:0.73, respectively, and the open-shell singlet lies 0.28 eV below the triplet state (n(f) accounts for f-hole occupancy; that is, n(f) = 1 when the configuration is f(13) and n(f) = 0 when the configuration is f(14)). A correlation is outlined between the value of nf and the individual ytterbocene and bipyridine fragments such that, as the reduction potentials of the ytterbocene cation and the free x,x'-R-2-bipy ligands approach each other, the value of nf and therefore the f(13):f(14) ratio reaches a maximum; conversely, the ratio is minimized as the disparity increases.

  19. Numerical Investigation of Interaction Between Hydraulic Fractures and Natural Fractures

    E-Print Network [OSTI]

    Xue, Wenxu

    2011-02-22T23:59:59.000Z

    Hydraulic fracturing of a naturally-fractured reservoir is a challenge for industry, as fractures can have complex growth patterns when propagating in systems of natural fractures in the reservoir. Fracture propagation near a natural fracture (NF...

  20. after-school program targeting: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Karl R; Wyatt, Mark C 2015-01-01 22 KT McDonald Muon Accelerator Program DoE Review (FNAL) August 30, 2012 1 Target and Absorbers Physics Websites Summary: In the IDS-NF...