Sample records for nf lrmp fs

  1. John H. Abel '90P 'F/S ++ Karen A. Adams '89G 'F/S ++

    E-Print Network [OSTI]

    Napier, Terrence

    /S J. Richard Aronson 'F/S Bradley J. Askins 'F/S ++ Henry S. Baird 'F/S Lisa A. Baker '10P 'F/S Mary K. Baker 'F/S ++ Robert F. Barnes, Jr. 'F/S Marcia M. Barone '86 '93G Catherine D. Barrett '70G 'F/S Donald. Holcombe '58 '69G '95P 'F/S ++ Barbara A. Holva 'F/S John A. Hughes 'F/S Mark Ironside 'F/

  2. John H. Abel, Jr. '90P 'F/S ++ Karen A. Adams '89G 'F/S ++

    E-Print Network [OSTI]

    Napier, Terrence

    /S ++ David J. Anastasio 'F/S Anne-Marie Anderson 'F/S N. Craig Anderson '60 '91P 'F/S ++ William R. Anderson/S Bradley J. Askins 'F/S ++ Mary K. Baker 'F/S ++ Edward S. Barndt '63 'F/S Robert F. Barnes, Jr. 'F/S ++ Stacey A. Blue 'F/S Marie C. Boltz 'F/S ++ Sarah C. Bombard '06 '08G 'F/S Donald H. Bott '54 'F

  3. mm-Wave Op-Amps employing simple-Miller compensation, with OIP3/PDC ratios of 211 (10 dB NF) and 144 (6.0 dB NF) at 2 GHz

    E-Print Network [OSTI]

    Rodwell, Mark J. W.

    mm-Wave Op-Amps employing simple-Miller compensation, with OIP3/PDC ratios of 211 (10 dB NF/PDC ratio at fs = 2-3 GHz, compared to state-of-the-art. We address considerations important 1000 mW power dissipation PDC . This very high ratio of output-referred third-order-intercept power

  4. Faculty and Staff LEHIGH UNIVERSITY 1 John H. Abel `90P `F/S ++

    E-Print Network [OSTI]

    Gilchrist, James F.

    /S Mount V. Allen III `F/S Dave C. Amidon, Jr. `F/S Anne-Marie Anderson `F/S Jill C. Anderson `91 `F/S Joanne C. Anderson `F/S N. Craig Anderson `60 `91P `F/S ++ William R. Anderson, Jr. `F/S J. Richard Aronson `F/S ++ Bradley J. Askins `F/S Mary K. Baker `F/S Nicholas W. Balabkins `F/S Christine M. Banzhoff

  5. Faculty and Staff LEHIGH UNIVERSITY 1 John H. Abel '90P 'F/S ++

    E-Print Network [OSTI]

    Gilchrist, James F.

    Faculty and Staff LEHIGH UNIVERSITY 1 John H. Abel '90P 'F/S ++ Karen A. Adams '89G 'F/S ++ Louise '60 '91P 'F/S ++ William R. Anderson, Jr. 'F/S Bradley J. Askins 'F/S Kimberly A. Backer 'F/S Henry S. Baird 'F/S Lisa A. Baker '10P 'F/S Mary K. Baker 'F/S Edward S. Barndt '63 'F/S Robert F. Barnes, Jr. 'F

  6. Faculty and Staff LEHIGH UNIVERSITY 1 John H. Abel `90P `F/S ++

    E-Print Network [OSTI]

    Napier, Terrence

    /S ++ Victoria P. Aitchison `92 ++ Mount V. Allen III `F/S ++ Dave C. Amidon, Jr. `F/S Joanne C. Anderson `F/S N. Craig Anderson `60 `91P `F/S ++ William R. Anderson, Jr. `F/S David C. Angstadt `87 `01G `05G `F/S J. Richard Aronson `F/S Bradley J. Askins `F/S ++ Henry S. Baird `F/S Lisa A. Baker `10P `F/S Mary K. Baker

  7. Sub-60-fs Timing Jitter of a SESAM Modelocked VECSEL

    E-Print Network [OSTI]

    Keller, Ursula

    Sub-60-fs Timing Jitter of a SESAM Modelocked VECSEL Volume 5, Number 1, February 2013 V. J.2012.2236546 1943-0655/$31.00 Ó2013 IEEE #12;Sub-60-fs Timing Jitter of a SESAM Modelocked VECSEL V. J with a highly linear photodiode and measured with a signal source analyzer. The resulting RMS timing jitter

  8. Making Linux protection mechanisms egalitarian with UserFS

    E-Print Network [OSTI]

    Kim, Taesoo, Ph. D. Massachusetts Institute of Technology

    2011-01-01T23:59:59.000Z

    UserFS provides egalitarian OS protection mechanisms in Linux. UserFS allows any user-not just the system administrator-to allocate Unix user IDs, to use chroot, and to set up firewall rules in order to confine untrusted ...

  9. Making Linux Protection Mechanisms Egalitarian with UserFS

    E-Print Network [OSTI]

    Kim, Taesoo

    UserFS provides egalitarian OS protection mechanisms in Linux. UserFS allows any user—not just the system administrator—to allocate Unix user IDs, to use chroot, and to set up firewall rules in order to confine untrusted ...

  10. Proper Use of Electric/Gas UtilityType Vehicles (FS4) Form FS-4 8/24/2011

    E-Print Network [OSTI]

    Beex, A. A. "Louis"

    Proper Use of Electric/Gas UtilityType Vehicles (FS4) Form FS-4 8/24/2011 Regulation Governing Use of Electric/Gas Utility­Type Vehicles (EGUV): Individual operators will use their judgment on whether. · Electric vehicles will be recharged at a location appropriate for such use. Use of extension cords from

  11. CEC-500-2010-FS-016 Cumulative Biological Impacts

    E-Print Network [OSTI]

    for Solar Energy Projects in the California Desert ENVIRONMENTAL AREA RESEARCH PIER Environmental ResearchCEC-500-2010-FS-016 Cumulative Biological Impacts Framework for Solar Energy Projects in the California Desert ENVIRONMENTAL AREA RESEARCH PIER Environmental Research www

  12. GlusterFS One Storage Server to Rule Them All

    SciTech Connect (OSTI)

    Boyer, Eric B. [Los Alamos National Laboratory; Broomfield, Matthew C. [Los Alamos National Laboratory; Perrotti, Terrell A. [Los Alamos National Laboratory

    2012-07-30T23:59:59.000Z

    GlusterFS is a Linux based distributed file system, designed to be highly scalable and serve many clients. Some reasons to use GlusterFS are: No centralized metadata server, Scalability, Open Source, Dynamic and live service modifications, Can be used over Infiniband or Ethernet, Can be tuned for speed and/or resilience and Flexible administration. It's useful for enterprise environments - virtualization; high performance computing (HPC) and it works with Mac, Linux and Windows clients. Conclusions are: (1) GlusterFS proved to have widespread capabilities as a virtual file system; (2) Scalability is very dependent upon the underlying hardware; (3) Lack of built-in encryption and security paradigm; and (4) Best suited in a general purpose computing environment.

  13. CEC-500-2010-FS-004 Development and Demonstration of

    E-Print Network [OSTI]

    -competitiveness of concentrating PV systems. · Improving grid stability by using an active inverter capable of injectingCEC-500-2010-FS-004 Development and Demonstration of a Concentrating PV System With Integrated Active Micro-Inverters RENEWABLE ENERGY RESEARCH PIER Renewable Energy Research www

  14. CEC-500-2010-FS-XXX New Microalgae Fermentation

    E-Print Network [OSTI]

    CEC-500-2010-FS-XXX New Microalgae Fermentation Process Used to Produce Biofuel TRANSPORTATION ENERGY RESEARCH PIER Transportation Research www.energy.ca.gov/research/ transportation/ May 2012 The Issue Dedicated energy crops provide a viable alternative to fossil fuels but compete with food crops

  15. NF Energy Saving Corp | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere I Geothermal Pwer PlantMunhall, Pennsylvania: Energy Resources JumpNEF Advisors LLC JumpNF Energy Saving Corp

  16. Quarry residuals RI/FS scoping document. [Weldon Spring quarry

    SciTech Connect (OSTI)

    Not Available

    1991-10-01T23:59:59.000Z

    The purpose of this document is to serve as a planning tool for the implementation of the Quarry Residual Remedial Investigation/Feasibility Study (RI/FS) process and to provide direct input to revising and updating the 1988 Work Plan for the Weldon Spring Site Remedial Action Project (WSSRAP) Remedial Investigation/Feasibility Study-Environmental Impact Statement for the Weldon Spring Site (RI/FS-EIS) (Peterson et al. 1988) for this effort. The scoping process is intended to outline the tasks necessary to develop and implement activities in compliance with the Comprehensive Environmental Response, Compensation and Liability Act-National Environmental Policy Act (CERCLA-NEPA) process from detailed planning through the appropriate decision document. In addition to scoping the entire process, this document will serve as the primary tool for planning and accomplishing all activities to be developed in the Quarry Residual RI/FS Work Plan. Subsequent tasks are difficult to plan at this time. 10 refs., 5 figs., 5 tabs.

  17. Single-shot 35 fs temporal resolution electron shadowgraphy

    SciTech Connect (OSTI)

    Scoby, C. M.; Li, R. K.; Threlkeld, E.; To, H.; Musumeci, P. [Department of Physics and Astronomy, UCLA, Los Angeles, California 90095 (United States)] [Department of Physics and Astronomy, UCLA, Los Angeles, California 90095 (United States)

    2013-01-14T23:59:59.000Z

    We obtain single-shot time-resolved shadowgraph images of the electromagnetic fields resulting from the interaction of a high intensity ultrashort laser pulse with a metal surface. Using a high brightness relativistic electron beam and a high streaking speed radiofrequency deflector, we report <35 fs temporal resolution enabling a direct visualization of the retarded-time dominated field evolution which follows the laser-induced charge emission. A model including the finite signal propagation speed well reproduces the data and yields measurements of fundamental parameters in short pulse laser-matter interaction such as the amount of emitted charge and the emission time scale.

  18. Audit Report: CR-FS-99-01

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation3 Audit Report:FS-97-02

  19. NF-?B Fans the Flames of Lung Carcinogenesis

    E-Print Network [OSTI]

    Jacks, Tyler E.

    This perspective on Deng et al. (beginning on p. 424 in this issue of the journal) examines the link between NF-?B and lung tumorigenesis. Experiments in genetically engineered mouse models of lung cancers are elucidating ...

  20. Universality of the Nf=2 Running Coupling

    E-Print Network [OSTI]

    K. Murano; S. Aoki; S. Takeda; Y. Taniguchi

    2009-03-06T23:59:59.000Z

    We investigate universality of the Nf=2 running coupling in the Sch\\"odinger functional scheme, by calculating the step scaling function in lattice QCD with the renorm alization group (RG) improved gauge action at both weak(u=0.9796) and strong(u=3.3340) couplings, where u=\\bar{g}^2_SF with \\bar{g}_SF being the running coupling in this scheme. In our main calculations, we use the tree-level value for O(a) improvement coefficients of boundary gauge fields. In addition we employ the 1-loop value for them in order to see how scaling behaviours are affected by them. In the continuum limit, the step scaling function obtained from the RG improved gauge actions agrees with the previous result obtained from the plaquette action within errors at both couplings, though errors of our result are larger. Combined fits using all data with the RG improved action as well as the plaquette action reduce errors in the continuum limit by 2% at the weak coupling and 22% at the strong coupling.

  1. Haploid reporter screens aimed at identification of NF-kappaB regulators

    E-Print Network [OSTI]

    Lee, Clarissa Ci

    2014-01-01T23:59:59.000Z

    Nuclear factor-kappaB (NF-KB) is a family of transcription factors that are essential for execution of both the innate and the adaptive immune response. NF-KB regulates hundreds of genes involved in critical processes such ...

  2. ELECTRON BUNCH PROFILE DIAGNOSTICS IN THE FEW FS REGIME USING COHERENT SMITH-PURCELL RADIATION

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    ', which is essential for the accurate reconstruction of the temporal bunch profile. INTRODUCTION New bunch length and profiles measurements down to the few fs FWHM regime. Coherent Smith-Purcell (CSP

  3. Survey on the D-module generated by f^s - Department of ...

    E-Print Network [OSTI]

    2014-03-10T23:59:59.000Z

    Let s be a new variable, and denote by Rf [s] · fs the free module. 65 ...... explore what (MC) could mean on a normal surface as ambient space and gives. 530.

  4. Wiederholungsprfungen Termine frs HS 2013 und FS 2014 (im KSL unter Leistungskontrolle 2. Termin erfasst)

    E-Print Network [OSTI]

    Mühlemann, Oliver

    Wiederholungsprüfungen ­ Termine fürs HS 2013 und FS 2014 (im KSL unter Leistungskontrolle 2. Termin erfasst) Bachelor Chemie Bachelor Biochemie Grundstudium Pharmazie Master Chemie und Molekulare Biochemie (Büro S170) für Veranstaltungen aus der Biochemie (°), falls Sie einen Termin abmachen möchten

  5. Rare Earth ? N = N* fs fGHZ fp nH fl

    E-Print Network [OSTI]

    Walter, Frederick M.

    Rare Earth ? #12;N to date N = N* fs fGHZ fp nH fl ·N* = 4 x 1011 ·fs = 0.2 ·fGHZ = 0.1 ·fp = 0.8 ·nH = 2 ·fl = 1.0 N = 1.3 x 1010 #12;The Goldilocks Effect Earth is "Just Right" Yes, life on Earth has adapted to Earth, but ... Earth has just the right mass to be ·Tectonically-active ·Retain

  6. Remedial Investigation/Feasibility Study (RI/FS) process, elements and techniques guidance

    SciTech Connect (OSTI)

    Not Available

    1993-12-01T23:59:59.000Z

    This manual provides detailed guidance on Remedial Investigation/Feasibility Studies (RI/FSs) conducted pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) at Department of Energy (DOE) facilities. The purpose of the RI/FS, to assess the risk posed by a hazardous waste site and to determine the best way to reduce that risk, and its structure (site characterization, risk assessment, screening and detailed analysis of alternatives, etc.) is defined in the National Oil and Hazardous Substances Pollution Contingency Plan (NCP) and further explained in the Environmental Protection Agency`s (EPA`s) Guidance for Conducting Remedial Investigations and Feasibility Studies Under CERCLA (Interim Final) 540/G-89/004, OSWER Directive 9355.3-01, October 1988. Though issued in 1988, the EPA guidance remains an excellent source of information on the conduct and structure of an RI/FS. This document makes use of supplemental RI/FS-related guidance that EPA has developed since its initial document was issued in 1988, incorporates practical lessons learned in more than 12 years of experience in CERCLA hazardous site remediation, and drawing on those lessons, introduces the Streamlined Approach For Environmental Restoration (SAFER), developed by DOE as a way to proceed quickly and efficiently through the RI/FS process at DOE facilities. Thus as its title implies, this guidance is intended to describe in detail the process and component elements of an RI/FS, as well as techniques to manage the RI/FS effectively.

  7. Audit Report: CR-FS-99-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation3 Audit Report:FS-97-02CR-FS-99-01

  8. Porcine arterivirus activates the NF-{kappa}B pathway through I{kappa}B degradation

    SciTech Connect (OSTI)

    Lee, Sang-Myeong [Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri-Columbia, MO 65211 (United States); Kleiboeker, Steven B. [Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri-Columbia, MO 65211 (United States) and Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri-Columbia, MO 65211 (United States)]. E-mail: KleiboekerS@Missouri.edu

    2005-11-10T23:59:59.000Z

    Nuclear factor-kappaB (NF-{kappa}B) is a critical regulator of innate and adaptive immune function as well as cell proliferation and survival. The present study demonstrated for the first time that a virus belonging to the Arteriviridae family activates NF-{kappa}B in MARC-145 cells and alveolar macrophages. In porcine reproductive and respiratory syndrome virus (PRRSV)-infected cells, NF-{kappa}B activation was characterized by translocation of NF-{kappa}B from the cytoplasm to the nucleus, increased DNA binding activity, and NF-{kappa}B-regulated gene expression. NF-{kappa}B activation was increased as PRRSV infection progressed and in a viral dose-dependent manner. UV-inactivation of PRRSV significantly reduced the level of NF-{kappa}B activation. Degradation of I{kappa}B protein was detected late in PRRSV infection, and overexpression of the dominant negative form of I{kappa}B{alpha} (I{kappa}B{alpha}DN) significantly suppressed NF-{kappa}B activation induced by PRRSV. However, I{kappa}B{alpha}DN did not affect viral replication and viral cytopathic effect. PRRSV infection induced oxidative stress in cells by generating reactive oxygen species (ROS), and antioxidants inhibited NF-{kappa}B DNA binding activity in PRRSV-infected cells, suggesting ROS as a mechanism by which NF-{kappa}B was activated by PRRSV infection. Moreover, NF-{kappa}B-dependent expression of matrix metalloproteinase (MMP)-2 and MMP-9 was observed in PRRSV-infected cells, an observation which implies that NF-{kappa}B activation is a biologically significant aspect of PRRSV pathogenesis. The results presented here provide a basis for understanding molecular pathways of pathology and immune evasion associated with disease caused by PRRSV.

  9. SF2I.7.pdf CLEO:2014 2014 OSA Emission and expansion features of ns and fs laser ablation

    E-Print Network [OSTI]

    Harilal, S. S.

    of an ambient leading to further excitation of plume species as well as enhancing excited molecular species and hydrodynamic expansion dynamics of ns and fs laser ablated metal plasmas in the presence of an ambient were studied. The structure and dynamics of both ns and fs plumes obtained from optical diagnostic

  10. Enterprise Architecture Analysis with XML F.S. de Boer1,2

    E-Print Network [OSTI]

    van der Torre, Leon

    Enterprise Architecture Analysis with XML F.S. de Boer1,2 M.M. Bonsangue2 J. Jacob1 A. Stam2,3 L, The Netherlands Abstract This paper shows how XML can be used for static and dynamic analysis of architectures. Our analysis is based on the distinction between symbolic and semantic models of architectures

  11. CEC-500-2010-FS-XXX Life-Cycle Energy

    E-Print Network [OSTI]

    CEC-500-2010-FS-XXX Life-Cycle Energy Assessment of Smart Growth Strategies TRANSPORTATION ENERGY growth strategies at reducing energy use, greenhouse gas emissions, and criteria pollutants remains. · An analysis of local planning and policy options for reducing embedded energy in the transport system

  12. GreenFS: Making Enterprise Computers Greener by Protecting Them Better

    E-Print Network [OSTI]

    Zadok, Erez

    the power consumption, noise, and data reliability problems without sacrificing hard disk life­time, dataFS improves enterprise data protection, minimizes disk drive­related power consumption and noise and increases and increase the power consumption of fans and air conditioners. In a densely packed server room heat removal

  13. GreenFS: Making Enterprise Computers Greener by Protecting Them Better

    E-Print Network [OSTI]

    Zadok, Erez

    the power consumption, noise, and data reliability problems without sacrificing hard disk life-time, dataFS improves enterprise data protection, minimizes disk drive-related power consumption and noise and increases and increase the power consumption of fans and air conditioners. In a densely packed server room heat removal

  14. CEC-500-2010-FS-XXX The Advanced Natural Gas

    E-Print Network [OSTI]

    CEC-500-2010-FS-XXX The Advanced Natural Gas Vehicle Fuel Tank Project TRANSPORTATION ENERGY role in reducing greenhouse gas emissions. Currently, natural gas vehicles are less competitive, and weight of conventional tanks continue to be barriers to increasing the use of natural gas

  15. CEC-500-2010-FS-XXX Natural Gas Engine and

    E-Print Network [OSTI]

    CEC-500-2010-FS-XXX Natural Gas Engine and Vehicle Integration Research TRANSPORTATION ENERGY ­ including natural gas ­ that can substantially reduce GHG emissions while reducing petroleum dependence. This research would increase the use of natural gas as a transportation fuel by developing advanced natural

  16. Availability of the St. Louis North County Site Feasibility Study and Proposed Plan (FS/PP) for Public Review and Comment

    E-Print Network [OSTI]

    US Army Corps of Engineers

    ). The North County FS/PP presents cleanup alternatives for the following sites: St. Louis Airport Site (SLAPS

  17. Smoothing single-crystalline SiC surfaces by reactive ion etching using pure NF{sub 3} and NF{sub 3}/Ar mixture gas plasmas

    SciTech Connect (OSTI)

    Tasaka, Akimasa, E-mail: aki-tasaka-load@yahoo.co.jp [Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321, Japan and Department of Applied Chemistry, Graduate School of Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321 (Japan); Kotaka, Yuki [Department of Applied Chemistry, Graduate School of Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321 (Japan); Oda, Atsushi; Saito, Morihiro [Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321 (Japan); Tojo, Tetsuro [Toyo Tanso Co, Ltd., 5-7-2 Takeshima, Nishi yodogawa-ku, Osaka 555-0011 (Japan); Inaba, Minoru [Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321, Japan and Department of Applied Chemistry, Graduate School of Science and Engineering, Doshisha University, 1-3 Miyako-dani, Tatara, Kyotanabe, Kyoto 610-0321 (Japan)

    2014-09-01T23:59:59.000Z

    In pure NF{sub 3} plasma, the etching rates of four kinds of single-crystalline SiC wafer etched at NF{sub 3} pressure of 2?Pa were the highest and it decreased with an increase in NF{sub 3} pressure. On the other hand, they increased with an increase in radio frequency (RF) power and were the highest at RF power of 200?W. A smooth surface was obtained on the single-crystalline 4H-SiC after reactive ion etching at NF{sub 3}/Ar gas pressure of 2?Pa and addition of Ar to NF{sub 3} plasma increased the smoothness of SiC surface. Scanning electron microscopy observation revealed that the number of pillars decreased with an increase in the Ar-concentration in the NF{sub 3}/Ar mixture gas. The roughness factor (R{sub a}) values were decreased from 51.5?nm to 25.5?nm for the As-cut SiC, from 0.25?nm to 0.20?nm for the Epi-SiC, from 5.0?nm to 0.7?nm for the Si-face mirror-polished SiC, and from 0.20?nm to 0.16?nm for the C-face mirror-polished SiC by adding 60% Ar to the NF{sub 3} gas. Both the R{sub a} values of the Epi- and the C-face mirror-polished wafer surfaces etched using the NF{sub 3}/Ar (40:60) plasma were similar to that treated with mirror polishing, so-called the Catalyst-Referred Etching (CARE) method, with which the lowest roughness of surface was obtained among the chemical mirror polishing methods. Etching duration for smoothing the single-crystalline SiC surface using its treatment was one third of that with the CARE method.

  18. 1 Managed by UT-Battelle for the U.S. Department of Energy NF Splash Mitigation 12 July 2011

    E-Print Network [OSTI]

    McDonald, Kirk

    1 Managed by UT-Battelle for the U.S. Department of Energy NF Splash Mitigation 12 July 2011 by UT-Battelle for the U.S. Department of Energy NF Splash Mitigation 12 July 2011 Splash Mitigation for comparison & final determination #12;3 Managed by UT-Battelle for the U.S. Department of Energy NF Splash

  19. Electron Bunch Profile Reconstruction in the Few fs Regime using Coherent Smith-Purcell Radiation

    SciTech Connect (OSTI)

    Bartolini, R.; /Oxford U., JAI /Diamond Light Source /SLAC; Clarke, C.; /SLAC; Delerue, N; /Oxford U., JAI /Diamond Light Source /SLAC; Doucas, G; Reichold, A; /Oxford U., JAI

    2012-06-20T23:59:59.000Z

    Advanced accelerators for fourth generation light sources based on high brightness linacs or laser-driven wakefield accelerators will operate with intense, highly relativistic electron bunches that are only a few fs long. Diagnostic techniques for the determination of temporal profile of such bunches are required to be non invasive, single shot, economic and with the required resolution in the fs regime. The use of a radiative process such as coherent Smith-Purcell radiation (SPR), is particularly promising with this respect. In this technique the beam is made to radiate a small amount of electromagnetic radiation and the temporal profile is reconstructed from the measured spectral distribution of the radiation. We summarise the advantages of SPR and present the design parameters and preliminary results of the experiments at the FACET facility at SLAC. We also discuss a new approach to the problem of the recovery of the 'missing phase', which is essential for the accurate reconstruction of the temporal bunch profile.

  20. IKK{epsilon} modulates RSV-induced NF-{kappa}B-dependent gene transcription

    SciTech Connect (OSTI)

    Bao Xiaoyong; Indukuri, Hemalatha; Liu Tianshuang; Liao Suiling [Department of Pediatrics, University of Texas Medical Branch, Galveston, TX (United States); Tian, Bing; Brasier, Allan R. [Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX (United States); Garofalo, Roberto P. [Department of Pediatrics, University of Texas Medical Branch, Galveston, TX (United States); Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX (United States); Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX (United States); Casola, Antonella, E-mail: ancasola@utmb.ed [Department of Pediatrics, University of Texas Medical Branch, Galveston, TX (United States); Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX (United States); Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX (United States)

    2010-12-20T23:59:59.000Z

    Respiratory syncytial virus (RSV), a negative-strand RNA virus, is the most common cause of epidemic respiratory disease in infants and young children. RSV infection of airway epithelial cells induces the expression of immune/inflammatory genes through the activation of a subset of transcription factors, including Nuclear Factor-{kappa}B (NF-{kappa}B). In this study we have investigated the role of the non canonical I{kappa}B kinase (IKK){epsilon} in modulating RSV-induced NF-{kappa}B activation. Our results show that inhibition of IKK{epsilon} activation results in significant impairment of viral-induced NF-{kappa}B-dependent gene expression, through a reduction in NF-{kappa}B transcriptional activity, without changes in nuclear translocation or DNA-binding activity. Absence of IKK{epsilon} results in a significant decrease of RSV-induced NF-{kappa}B phosphorylation on serine 536, a post-translational modification important for RSV-induced NF-{kappa}B-dependent gene expression, known to regulate NF-{kappa}B transcriptional activity without affecting nuclear translocation. This study identifies a novel mechanism by which IKK{epsilon} regulates viral-induced cellular signaling.

  1. Homeostatic control of IkappaB metabolism determines NF- kappaB responsiveness

    E-Print Network [OSTI]

    O'Dea, Ellen Louise

    2010-01-01T23:59:59.000Z

    19-26. O'Dea, E. and Hoffmann, A. 2009. NF-kappaB signaling.J.D. , Levchenko, A. , and Hoffmann, A. 2007. A homeostaticS.L. , Cheng, C. , and Hoffmann, A. 2007. A temporal code

  2. Response and Resistance to NF-?B Inhibitors in Mouse Models of Lung Adenocarcinoma

    E-Print Network [OSTI]

    Xue, Wen

    Lung adenocarcinoma is a leading cause of cancer death worldwide. We recently showed that genetic inhibition of the NF-?B pathway affects both the initiation and the maintenance of lung cancer, identifying this pathway as ...

  3. Requirement for NF-?B signalling in a mouse model of lung adenocarcinoma

    E-Print Network [OSTI]

    Meylan, Etienne

    NF-?B transcription factors function as crucial regulators of inflammatory and immune responses as well as of cell survival. They have also been implicated in cellular transformation and tumorigenesis. However, despite ...

  4. BGOU FS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    V-shaped jet-grouted composite barriers were demonstrated at Brookhaven and the Hanford site (Dwyer 1994) and at Fernald in 1992 (Pettit et al. 1996) in attempts to...

  5. FS Agre

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA group currentBradleyTableSelling7111AWell:F E ," POST RmDIAL8FISKFOR

  6. Time-resolved spectroscopy and photometry of the dwarf nova FS Aurigae in quiescence

    E-Print Network [OSTI]

    V. V. Neustroev

    2001-10-26T23:59:59.000Z

    We present results of non-simultaneous time-resolved photometric and spectroscopic observations of the little-studied dwarf nova FS Aur in quiescence. The spectrum of FS Aur shows strong and broad emission lines of hydrogen and HeI, and of weaker HeII 4686 and CIII/NIII blend, similar to other quiescent dwarf novae. All emission lines are single-peaked, however their form varies with orbital phase. Absorption lines from a late-type secondary are not detected. From the radial velocity measurements of the hydrogen lines H$_\\beta$ and H$_\\gamma$ we determined a most probable orbital period P=0.059+-0.002. This period agrees well with the 0.0595+-0.0001 estimate by Thorstensen et al. (1996). On the other hand, the period of photometric modulations is longer than the spectroscopic period and can be estimated as 3 hours. Longer time coverage during a single night is needed to resolve this problem. Using the semi-amplitude of the radial velocities, obtained from measurements of hydrogen and helium lines, and some empirical and theoretical relations we limited the basic parameters of the system: a mass ratio q>=0.22, a primary mass M_1=0.34 - 0.46 M_sun, a secondary mass M_2<= 0.1M_sun, and an inclination angle i=51^{\\circ} - 65^{\\circ}. Doppler tomography has shown at least two bright regions in the accretion disk of FS Aur. The first, brighter spot is located at phase about 0.6. The second spot is located opposite the first one and occupies an extensive area at phases about 0.85 - 1.15.

  7. A test of first order scaling in Nf=2 QCD

    E-Print Network [OSTI]

    G. Cossu; M. D'Elia; A. Di Giacomo; C. Pica

    2007-09-30T23:59:59.000Z

    We complete our analysis of Nf=2 QCD based on the lattice staggered fermion formulation. Using a series of Monte Carlo simulations at fixed (amq*Ls^yh) one is able to test the universality class with given critical exponent yh. This strategy has been used to test the O(4) universality class and it has been presented at the previous Lattice conferences. No agreement was found with simulations in the mass range amq=[0.01335,0.15] using lattices with Ls=16 up to 32 and Lt=4. With the same strategy, we now investigate the possibility of a first order transition using a new set of Monte Carlo data corresponding to yh=3 in the same mass and volume range as the one used for O(4). A substantial agreement is observed both in the specific heat scaling and in the scaling of the chiral condensate, while the chiral susceptibilities still presents visible deviation from scaling in the mass range explored.

  8. 190-fs passively mode-locked thulium fiber laser with a low threshold

    SciTech Connect (OSTI)

    Sharp, R.C.; Spock, D.E.; Pan, N.; Elliot, J. [Raytheon Company, Electronic Systems, 131 Spring Street, Lexington, Massachusetts 02173 (United States)

    1996-06-01T23:59:59.000Z

    We report a self-starting passively mode-locked thulium-doped silica fiber laser capable of 190-fs pulses. This practical, compact package is driven by a single 50-mW passively cooled diode laser, has a launched pump-power threshold of 18 mW for mode locking, and produces a 50-MHz train of mode-locked 20-pJ pulses at a wavelength near 1.9 {mu}m. {copyright} {ital 1996 Optical Society of America.}

  9. Audit Report: OAS-FS-15-11 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed off Energy.gov. Are you sure you want toworldPower 2010 1A PotentialAllisonof EnergyFS-15-11

  10. Audit Report: CR-FS-96-03 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed off Energy.gov. Are you0 ARRA NewslettersPartnership1/08 AttendanceCR-B-98-02 AuditCR-FS-96-03 Audit

  11. Audit Report: CR-FS-97-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation3 Audit Report:FS-97-02 Audit

  12. Audit Report: OAS-FS-07-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation38-06IG-0803IG-08931 AuditFS-07-02

  13. Audit Report: OAS-FS-11-07 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation38-06IG-0803IG-08931FS-11-07 Audit

  14. Audit Report: OAS-FS-12-10 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation38-06IG-0803IG-08931FS-11-07

  15. Audit Report: OAS-FS-13-05 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation38-06IG-0803IG-08931FS-11-07Audit

  16. Audit Report: WR-FS-99-04 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName4 AuditM-15-03RA-L-12-06WR-FS-99-04 Audit

  17. USDA-FS-EA-NV-030-06-025 2012 | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to:Ezfeedflag JumpID-fTri Global Energy LLC Place: Dallas,UGIURDB Ell-SalineFS-EA-NV-030-06-025

  18. Sci. Aging Knowl. Environ., Vol. 2004, Issue 34, pp. nf78, 25 August 2004 [DOI: 10.1126/sageke.2004.34.nf78

    E-Print Network [OSTI]

    Seroude, Laurent

    : They scrubbed fly eggs with alcohol, fed the animals irradiated food, and kept them in sterile containers: http://sageke.sciencemag.org/cgi/content/full/2004/34/nf78 Nasty germs in fast-food burgers can kill direction--from fare that included antibiotics to "dirty" food--extended fly life on day 2 but not on day 4

  19. Streamlining the OU3 RI/FS process to accommodate decontamination and dismantlement at Fernald

    SciTech Connect (OSTI)

    Hampshire, L.H.; Dalga, D.G.; Clark, T.R.; Throckmorton, J.D. [Fernald Environmental Restoration Management Corp., Cincinnati, OH (United States); Janke, R.J. [USDOE Fernald Field Office, OH (United States)

    1993-12-01T23:59:59.000Z

    The importance of a proper and complete assessment of data needs, relative to the characterization of a site, can never be understated. Not only will this assessment assure that the appropriate types, levels, and numbers of samples are taken, but as evidenced by the subject project, can lead to significant time and cost savings. The Fernald Environmental Management Project (FEMP), formerly known as the Feed Materials Production Center (FMPC), covers an area measuring 4.25 square kilometers (1,050 acres) and is located in a rural agricultural area about 28 kilometers (17 miles) northwest of downtown Cincinnati, Ohio. The site is near the villages of Fernald, New Haven, Ross, and Shandon, Ohio. After providing some general background information on the site, and the subject RI/FS, the remainder of this presentation will focus on how the sampling approach was changed to reflect a reassessment of data needs, and the resultant benefits of that change. Specifically, discussion will be provided relative to the initial approach proposed for characterizing the contamination at the site, the revised, improved sampling approach contained in the approved RI/FS Work Plan Addendum, and the benefits derived from this change in the sampling approach.

  20. A compact streak camera for 150 fs time resolved measurement of bright pulses in ultrafast electron diffraction

    SciTech Connect (OSTI)

    Kassier, G. H.; Haupt, K.; Erasmus, N.; Rohwer, E. G.; Bergmann, H. M. von; Schwoerer, H. [Laser Research Institute, University of Stellenbosch, Private Bag X1, 7602 Matieland (South Africa); Coelho, S. M. M.; Auret, F. D. [Department of Physics, University of Pretoria, Pretoria 0002 (South Africa)

    2010-10-15T23:59:59.000Z

    We have developed a compact streak camera suitable for measuring the duration of highly charged subrelativistic femtosecond electron bunches with an energy bandwidth in the order of 0.1%, as frequently used in ultrafast electron diffraction (UED) experiments for the investigation of ultrafast structural dynamics. The device operates in accumulation mode with 50 fs shot-to-shot timing jitter, and at a 30 keV electron energy, the full width at half maximum temporal resolution is 150 fs. Measured durations of pulses from our UED gun agree well with the predictions from the detailed charged particle trajectory simulations.

  1. Emissions of PCDD/Fs from municipal solid waste incinerators in China Yuwen Ni, Haijun Zhang, Su Fan, Xueping Zhang, Qing Zhang, Jiping Chen *

    E-Print Network [OSTI]

    Columbia University

    Emissions of PCDD/Fs from municipal solid waste incinerators in China Yuwen Ni, Haijun Zhang, Su February 2009 Available online 21 March 2009 Keywords: MSWIs PCDD/Fs Congener patterns Emission factor a b s t r a c t Gas emission of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD

  2. Structural information extracted from the diffraction of XFEL fs-pulses in a crystal

    E-Print Network [OSTI]

    Leonov, A; Benediktovitch, A; Feranchuk, I; Pietsch, U

    2015-01-01T23:59:59.000Z

    We present a theoretical justification for a method of extracting of supplementary information for the phase retrieval procedure taken from diffraction of fs-pulses from X-ray Free Electron Laser facilities. The approach is based on numerical simulation of the dynamics of the electron density in the crystal composed of different atoms in the unit cell, namely a bi-atomic crystal containing heavy and light atoms. It is shown that evaluation of diffraction intensities measured by means of different values of XFEL pulse parameters enables to find absolute values of structure factors for both types of atoms and their relative phase. The accuracy of structural information is discussed in terms of fluctuations of the evaluated atomic scattering factors. Our approach could be important for improvement of phase retrieval methods with respect to a more efficient determination of atomic positions within the unit cell of macromolecules.

  3. The Proton-Driven Rotor of ATP Synthase: Ohmic Conductance (10 fS), and Absence of Voltage Gating

    E-Print Network [OSTI]

    Junge, Wolfgang

    The Proton-Driven Rotor of ATP Synthase: Ohmic Conductance (10 fS), and Absence of Voltage Gating portion of F0F1-ATP synthase, F0, translocates protons by a rotary mechanism. Proton conduction by F0-induced voltage jump was monitored by electrochromic absorption transients to yield the unitary conductance of F0

  4. MasterProof The Proton-Driven Rotor of ATP Synthase: Ohmic Conductance (10 fS),

    E-Print Network [OSTI]

    Steinhoff, Heinz-Jürgen

    MasterProof The Proton-Driven Rotor of ATP Synthase: Ohmic Conductance (10 fS), and Absence ABSTRACT The membrane portion of F0F1-ATP synthase, F0, translocates protons by a rotary mechanism. Proton conduction by F0 was studied in chromatophores of the photosynthetic bacterium Rhodobacter capsulatus

  5. NF-?B1 Inhibits TLR-Induced IFN-? Production in Macrophages Through TPL-2-dependent ERK Activation

    E-Print Network [OSTI]

    Yang, Huei-Ting

    Although NF-?B1 p50/p105 has critical roles in immunity, the mechanism by which NF-?B1 regulates inflammatory responses is unclear. In this study, we analyzed the gene expression profile of LPS-stimulated Nfkb1?/? macrophages ...

  6. XIAP and cIAP1 amplifications induce Beclin 1-dependent autophagy through NF?B activation

    E-Print Network [OSTI]

    Lin, Fang; Ghislat, Ghita; Luo, Shouqing; Renna, Maurizio; Siddiqi, Farah; Rubinsztein, David C.

    2015-02-10T23:59:59.000Z

    ). In both steady state and stimulated conditions with TGF? that activates NF?B through TAK1 (33), nei- ther the overexpression of XIAP nor its knockdown affected the transcriptional activation of the NF?B promoter (Fig. 3B, top). The effect of TGF?...

  7. Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells

    SciTech Connect (OSTI)

    Jian Li

    2012-11-07T23:59:59.000Z

    A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

  8. Instruction sheet for the consolidation of the standard NF EN 693 dated September 2001 and its amendment A1 Machine tools : Safety : Hydraulic presses

    E-Print Network [OSTI]

    Association Française de Normalisation. Paris

    2009-01-01T23:59:59.000Z

    Instruction sheet for the consolidation of the standard NF EN 693 dated September 2001 and its amendment A1

  9. 1 Managed by UT-Battelle for the U.S. Department of Energy NF-IDS Videoconference 2 Jun 2009

    E-Print Network [OSTI]

    McDonald, Kirk

    1 Managed by UT-Battelle for the U.S. Department of Energy NF-IDS Videoconference 2 Jun 2009 by UT-Battelle for the U.S. Department of Energy NF-IDS Videoconference 2 Jun 2009 Purpose · Compare · Compilation of magnet geometry data #12;3 Managed by UT-Battelle for the U.S. Department of Energy NF

  10. Introduction The NF-B/Rel family of transcription factors is composed of

    E-Print Network [OSTI]

    Arnold, Jonathan

    gene expression exhibited a requirement for the host IKK complex. A detailed kinetic analysis of NF- B expression of anti-apoptotic genes and prevent death of infected cells in order to allow replication in a loss of the anti-apoptotic phenotype and a decrease in pro-survival gene expression (Molestina et al

  11. Single-cell NF-kB dynamics reveal digital activation and analogue information processing

    E-Print Network [OSTI]

    Quake, Stephen R.

    LETTERS Single-cell NF-kB dynamics reveal digital activation and analogue information processing and is a digital process at the single-cell level with fewer cells responding at lower doses. Cells also encode that reproduces both the digital and analogue dynamics as well as most gene expression profiles at all measured

  12. Microstructural Evolution in Two Variants of NF709 at 1023 and 1073 K

    E-Print Network [OSTI]

    Cambridge, University of

    and that could invalidate the extrapolations of short-term creep test data, and to identify any precipitates.K.D.H. BHADESHIA The microstructural state of two grades of the creep-resistant austenitic stainless steels NF709 regarded as one of the best austenitic steels for elevated temperature applications because of its creep

  13. Coal dust contiguity-induced changes in the concentration of TNF- and NF- B p65 on the ocular surface

    SciTech Connect (OSTI)

    Sun, Z.Y.; Hong, J.; Liu, Z.Y.; Jin, X.D.; Gu, C.H. [China Medical University, Shenyang (China)

    2009-07-01T23:59:59.000Z

    To observe the influence of coal dust on ocular surface of coal miners and rabbits with coal dust contiguity on expression TNF- and NF- Bp65 and dry eye occurrence. Expression TNF- and NF- Bp65 in ocular surface were determined. Results showed tear production, BUT and lysozyme decreased for coal miners and rabbits with coal dust contiguity. Coal dust exposure was linked to development of xerophthalmia, and induced a higher expression of NF- B p65 and TNF- perhaps as a mechanism to resist coal dust ocular surface injury.

  14. Observation of excited state charge transfer with fs/ps-CARS

    SciTech Connect (OSTI)

    Blom, Alex Jason

    2009-08-01T23:59:59.000Z

    Excited state charge transfer processes are studied using the fs/ps-CARS probe technique. This probe allows for multiplexed detection of Raman active vibrational modes. Systems studied include Michler's Ketone, Coumarin 120, 4-dimethylamino-4{prime}-nitrostilbene, and several others. The vibrational spectrum of the para di-substituted benzophenone Michler's Ketone in the first excited singlet state is studied for the first time. It is found that there are several vibrational modes indicative of structural changes of the excited molecule. A combined experimental and theoretical approach is used to study the simplest 7-amino-4-methylcoumarin, Coumarin 120. Vibrations observed in FTIR and spontaneous Raman spectra are assigned using density functional calculations and a continuum solvation model is used to predict how observed modes are affected upon inclusion of a solvent. The low frequency modes of the excited state charge transfer species 4-dimethylamino-4{prime}-nitrostilbene are studied in acetonitrile. Results are compared to previous work on this molecule in the fingerprint region. Finally, several partially completed projects and their implications are discussed. These include the two photon absorption of Coumarin 120, nanoconfinement in cyclodextrin cavities and sensitization of titania nanoparticles.

  15. COMPLETE TRACKING OF PROTON FLOW IN THYLAKOIDS THE UNIT CONDUCTANCE OF CFo IS GREATER THAN 10 fS

    E-Print Network [OSTI]

    Schönknecht, Gerald

    further 20% of CF1 and increased the proton permeability of membranes by 3 orders of magnitude. In control, B, y, .sand £· 3 subunits (a, band c) are found for bacterial F0 , while 4 subunits (IV, I and III low, some percent of a 213 #12;femto-Siemens (fS) [6,8]. than 100 protons/sand F0 · 900 protons

  16. Theoretical study of electronic damage in single particle imaging experiments at XFELs for pulse durations 0.1 - 10 fs

    E-Print Network [OSTI]

    Gorobtsov, O Yu; Kabachnik, N M; Vartanyants, I A

    2015-01-01T23:59:59.000Z

    X-ray free-electron lasers (XFELs) may allow to employ the single particle imaging (SPI) method to determine the structure of macromolecules that do not form stable crystals. Ultrashort pulses of 10 fs and less allow to outrun complete disintegration by Coulomb explosion and minimize radiation damage due to nuclear motion, but electronic damage is still present. The major contribution to the electronic damage comes from the plasma generated in the sample that is strongly dependent on the amount of Auger ionization. Since the Auger process has a characteristic time scale on the order of femtoseconds, one may expect that its contribution will be significantly reduced for attosecond pulses. Here, we study the effect of electronic damage on the SPI at pulse durations from 0.1 fs to 10 fs and in a large range of XFEL fluences to determine optimal conditions for imaging of biological samples. We analyzed the contribution of different electronic excitation processes and found that at fluences higher than $10^{13}$-$...

  17. Omentin inhibits TNF-{alpha}-induced expression of adhesion molecules in endothelial cells via ERK/NF-{kappa}B pathway

    SciTech Connect (OSTI)

    Zhong, Xia, E-mail: zhongxia1977@126.com [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)] [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China); Li, Xiaonan; Liu, Fuli; Tan, Hui [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)] [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China); Shang, Deya, E-mail: wenhuashenghuo1@163.com [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)] [Department of Emergency, Provincial Hospital Affiliated to Shandong University, Jinan 250021 (China)

    2012-08-24T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Omentin inhibited TNF-{alpha}-induced adhesion of THP-1 cells to HUVECs. Black-Right-Pointing-Pointer Omentin reduces expression of ICAM-1 and VCAM-1 induced by TNF-{alpha} in HUVECs. Black-Right-Pointing-Pointer Omentin inhibits TNF-{alpha}-induced ERK and NF-{kappa}B activation in HUVECs. Black-Right-Pointing-Pointer Omentin supreeses TNF-{alpha}-induced expression of ICAM-1 and VCAM-1 via ERK/NF-{kappa}B pathway. -- Abstract: In the present study, we investigated whether omentin affected the expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in tumor necrosis factor-{alpha} (TNF-{alpha}) induced human umbilical vein endothelial cells (HUVECs). Our data showed that omentin decreased TNF-{alpha}-induced expression of ICAM-1 and VCAM-1 in HUVECs. In addition, omentin inhibited TNF-{alpha}-induced adhesion of THP-1 cells to HUVECs. Further, we found that omentin inhibited TNF-{alpha}-activated signal pathway of nuclear factor-{kappa}B (NF-{kappa}B) by preventing NF-{kappa}B inhibitory protein (I{kappa}B{alpha}) degradation and NF-{kappa}B/DNA binding activity. Omentin pretreatment significantly inhibited TNF-{alpha}-induced ERK activity and ERK phosphorylation in HUVECs. Pretreatment with PD98059 suppressed TNF-{alpha}-induced NF-{kappa}B activity. Omentin, NF-kB inhibitor (BAY11-7082) and ERK inhibitor (PD98059) reduced the up-regulation of ICAM-1 and VCAM-1 induced by TNF-{alpha}. These results suggest that omentin may inhibit TNF-{alpha}-induced expression of adhesion molecules in endothelial cells via blocking ERK/NF-{kappa}B pathway.

  18. $Re(A_0)$, $Re(A_2)$ and RG evolution for $N_f=3$

    E-Print Network [OSTI]

    Choi, K; Choi, Keunsu; Lee, Weonjong

    2005-01-01T23:59:59.000Z

    We present results of $Re (A_0)$ and $Re (A_2)$ calculated using HYP staggered fermions on the lattice of $16^3 \\times 64$ at $\\beta=6.0$. These results are obtained using leading order chiral perturbation in quenched QCD. Buras's original RG evolution matrix develops a removable singularity for $N_f=3$. This subtlety is resolved by finding a finite solution to RG equation and the results are presented.

  19. Agreement Execution Process Study: CRADAs and NF-WFO Agreements and the Speed of Business

    SciTech Connect (OSTI)

    Harrer, Bruce J.; Cejka, Cheryl L.; Macklin, Richard; Miksovic, Ann

    2011-02-01T23:59:59.000Z

    This report summarizes the findings of a study on the execution of Cooperative Research and Development Agreements (CRADAs) and Non-Federal Work for Others (NF-WFO) agreements across the U.S. Department of Energy (DOE) laboratory complex. The study provides quantitiative estimates of times required to negotiate and execute these agreements across the DOE complex. It identifies factors impacting on cycle times and describes best practicies used at various laboratories and site offices that reduce cycle times.

  20. NF-{kappa}B suppresses HIF-1{alpha} response by competing for P300 binding

    SciTech Connect (OSTI)

    Mendonca, Daniela B.S., E-mail: daniela_mendonca@dentistry.unc.edu [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil); Bone Biology and Implant Therapy Laboratory, Department of Prosthodontics, University of North Carolina at Chapel Hill, 330 Brauer Hall, CB 7450, Chapel Hill, NC 27599 (United States); Mendonca, Gustavo [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil) [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil); Bone Biology and Implant Therapy Laboratory, Department of Prosthodontics, University of North Carolina at Chapel Hill, 330 Brauer Hall, CB 7450, Chapel Hill, NC 27599 (United States); Aragao, Francisco J.L. [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil) [Universidade Catolica de Brasilia, Pos-Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av. W5 Norte, 70790-160 Brasilia, DF (Brazil); Embrapa Recursos Geneticos e Biotecnologia, Laboratorio de Introducao e Expressao de Genes, PqEB W5 Norte, 70770-900 Brasilia, DF (Brazil); Cooper, Lyndon F., E-mail: lyndon_cooper@dentistry.unc.edu [Bone Biology and Implant Therapy Laboratory, Department of Prosthodontics, University of North Carolina at Chapel Hill, 330 Brauer Hall, CB 7450, Chapel Hill, NC 27599 (United States)

    2011-01-28T23:59:59.000Z

    Research highlights: {yields} p65 completely blocked HIF-1{alpha} activity at the HRE on different cell lines. {yields} p65 caused minor changes in HIF-1{alpha} and HIF-1{alpha} target genes mRNA expression. {yields} p65 reduced transcription of VEGF promoter. {yields} p65 competes with HIF-1{alpha} for p300. -- Abstract: Hypoxia has emerged as a key determinant of osteogenesis. HIF-1{alpha} is the transcription factor mediating hypoxia responses that include induction of VEGF and related bone induction. Inflammatory signals antagonize bone repair via the NF-{kappa}B pathway. The present investigation explored the functional relationship of hypoxia (HIF-1{alpha} function) and inflammatory signaling (NF-{kappa}B) in stem like and osteoprogenitor cell lines. The potential interaction between HIF-1{alpha} and NF-{kappa}B signaling was explored by co-transfection studies in hFOB with p65, HIF-1{alpha} and 9x-HRE-luc or HIF-1{alpha} target genes reporter plasmids. Nuclear cross-talk was directly tested using the mammalian Gal4/VP16 two-hybrid, and confirmed by co-immunoprecipitation/western blotting assays. The results show that inflammatory stimulation (TNF-{alpha} treatment) causes a marked inhibition of HIF-1{alpha} function at the HRE in all cell lines studied. Also, co-transfection with p65 expression vector leads to reduced hVEGFp transcription after DFO-induced hypoxia. However, TNF-{alpha} treatment had little effect on HIF-1{alpha} mRNA levels. The functional interaction of Gal4-HIF-1{alpha} and VP16-p300 fusion proteins is effectively blocked by expression of p65 in a dose dependent manner. It was concluded that NF-{kappa}B-mediated inflammatory signaling is able to block HIF-1{alpha} transactivation at HRE-encoding genes by direct competition for p300 binding at the promoter. Inflammation may influence the stem cell niche and tissue regeneration by influencing cellular responses to hypoxia.

  1. IDS-NF Impact of Neutrino Cross Section Impact of Neutrino Cross Section

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh School footballHydrogen andHypernuclei in Hall CInbydoeCELLIDRMSIDS-NF

  2. FY13 Summary Report on the Augmentation of the Spent Fuel Composition Dataset for Nuclear Forensics: SFCOMPO/NF

    SciTech Connect (OSTI)

    Brady Raap, Michaele C.; Lyons, Jennifer A.; Collins, Brian A.; Livingston, James V.

    2014-03-31T23:59:59.000Z

    This report documents the FY13 efforts to enhance a dataset of spent nuclear fuel isotopic composition data for use in developing intrinsic signatures for nuclear forensics. A review and collection of data from the open literature was performed in FY10. In FY11, the Spent Fuel COMPOsition (SFCOMPO) excel-based dataset for nuclear forensics (NF), SFCOMPO/NF was established and measured data for graphite production reactors, Boiling Water Reactors (BWRs) and Pressurized Water Reactors (PWRs) were added to the dataset and expanded to include a consistent set of data simulated by calculations. A test was performed to determine whether the SFCOMPO/NF dataset will be useful for the analysis and identification of reactor types from isotopic ratios observed in interdicted samples.

  3. ABD56 causes osteoclast apoptosis by inhibiting the NF{kappa}B and ERK pathways

    SciTech Connect (OSTI)

    Idris, Aymen [Rheumatic Diseases Unit, Molecular Medicine Centre, University of Edinburgh, General Western Hospital, Edinburgh, EH4 2XU (United Kingdom); Mrak, Emanuela [Bone Metabolic Unit, Scientific Institute H San Raffaele, via Olgettina 60, 20132 Milano (Italy); Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, via Vanvitelli 32, 20129 Milano (Italy); Greig, Iain [Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD (United Kingdom); Guidobono, Francesca [Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, via Vanvitelli 32, 20129 Milano (Italy); Ralston, Stuart H. [Rheumatic Diseases Unit, Molecular Medicine Centre, University of Edinburgh, General Western Hospital, Edinburgh, EH4 2XU (United Kingdom); Hof, Rob van 't [Rheumatic Diseases Unit, Molecular Medicine Centre, University of Edinburgh, General Western Hospital, Edinburgh, EH4 2XU (United Kingdom)], E-mail: rvanthof@staffmail.ed.ac.uk

    2008-06-20T23:59:59.000Z

    We have previously shown that the biphenylcarboxylic acid butanediol ester (ABD56) inhibits osteoclast formation and activity in vitro and in vivo. However, the mechanism of action of this compound is unknown. ABD56 inhibited osteoclast formation and caused osteoclast apoptosis, but had no effects on osteoblasts or macrophages. As the NF{kappa}B and MAPK pathways are essential for osteoclast formation and survival, we studied the effects of ABD56 on these pathways. ABD56 caused phosphorylation of p38, JNK and nuclear translocation of c-jun in osteoclasts. ABD56-induced apoptosis was prevented by the caspase inhibitor zVAD-fmk but was not prevented by the p38- or JNK-inhibitors. ABD56 completely abolished RANKL-induced I{kappa}B and ERK1/2 phosphorylation. Increasing the amount of RANKL partially rescued ABD56-induced apoptosis, indicating that the apoptosis is most probably due to the inhibition of survival signals such as ERK and NF{kappa}B, rather than activation of the p38 or Jnk MAPK pathways.

  4. Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-{kappa}B in hepatoma cells

    SciTech Connect (OSTI)

    Zhao, Yu [Department of Biochemistry, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071 (China)] [Department of Biochemistry, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071 (China); Wang, Wenhui [Department of Interventional Radiography, First Hospital of Lanzhou University, No.1 Donggang West Road, Lanzhou, Gansu Province 730000 (China)] [Department of Interventional Radiography, First Hospital of Lanzhou University, No.1 Donggang West Road, Lanzhou, Gansu Province 730000 (China); Wang, Qi [Department of Cancer Research, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China)] [Department of Cancer Research, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China); Zhang, Xiaodong, E-mail: zhangxd@nankai.edu.cn [Department of Cancer Research, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China)] [Department of Cancer Research, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071 (China); Ye, Lihong, E-mail: yelihong@nankai.edu.cn [Department of Biochemistry, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071 (China)] [Department of Biochemistry, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071 (China)

    2012-02-24T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer 5-LOX is able to upregulate expression of NF-{kappa}B p65. Black-Right-Pointing-Pointer 5-LOX enhances nuclear translocation of NF-{kappa}B p65 via increasing p-I{kappa}B-{alpha} level. Black-Right-Pointing-Pointer 5-LOX stimulates transcriptional activity of NF-{kappa}B in hepatoma cells. Black-Right-Pointing-Pointer LTB4 activates transcriptional activity of NF-{kappa}B in hepatoma cells. -- Abstract: The issue that lipid metabolism enzyme and its metabolites regulate transcription factors in cancer cell is not fully understood. In this study, we first report that the lipid metabolism enzyme 5-Lipoxygenase (5-LOX) and its metabolite leukotriene B4 (LTB4) are capable of activating nuclear factor-{kappa}B (NF-{kappa}B) in hepatoma cells. We found that the treatment of MK886 (an inhibitor of 5-LOX) or knockdown of 5-LOX was able to downregulate the expression of NF-{kappa}B p65 at the mRNA level and decreased the phosphorylation level of inhibitor {kappa}B{alpha} (I{kappa}B{alpha}) in the cytoplasm of hepatoma HepG2 or H7402 cells, which resulted in the decrease of the level of nuclear NF-{kappa}B p65. These were confirmed by immunofluorescence staining in HepG2 cell. Moreover, the above treatments were able to decrease the transcriptional activity of NF-{kappa}B in the cells. The LTB4, one of metabolites of 5-LOX, is responsible for 5-LOX-activated NF-{kappa}B in a dose-dependent manner. Thus, we conclude that the lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-{kappa}B in hepatoma cells. Our finding provides new insight into the significance of lipid metabolism in activation of transcription factors in cancer.

  5. RELAP5/MOD3 assessment using the Semiscale 50% Feed Line Break test S-FS-11

    SciTech Connect (OSTI)

    Lee, E.J.; Chung, B.D.; Kim, H.J. [Korea Inst. of Nuclear Safety, Taejon (Korea, Republic of)

    1993-06-01T23:59:59.000Z

    The RELAP5/MOD3 5m5 code was assessed using the 1/1705 volume scaled Semiscale 50% Feed Line Break (FLB) test S-FS-11. Test S-FS-11 was designed in three phases: (a) blowdown phase, (b) stabilization phase, and (c) refill phase. The first objective was to assess the code applicability to 50% FLB situation, the second was to evaluate the FSAR conservatisms regarding SG heat transfer degradation, steam line check valve failure, break flow state, and peak primary system pressure, and the third was to validate the EOP effectiveness. The code was able to simulate the major T/H parameters except for the two-phase break flow and the secondary convective heat transfer rate. The two-phase break flow had still deficiencies. The current boiling heat transfer rate was developed from the data for flow inside of a heated tube, not for flow around heated tubes in a tube bundle. Results indicated that the assumption of 100% heat transfer until the liquid inventory depletion was not conservative, the failed affected steam generator main steam line check valve assumption was not either conservative, the measured break flow experienced all types of flow conditions, the relative proximity to the 110% design pressure limit was conservative. The automatic actions during the blowdown phase were effective in mitigating the consequences. The stabilization operation performed by operator actions were effective to permit natural circulation cooldown and depressurization. The voided secondary refill operations also verified the effectiveness of the operations while recovering the inventory in a voided steam generator.

  6. JOURNAL DE PHYSIQUE CoZZoque CZO, suppldment au n012, Tom 41, ddcembre 1980, page C10-1 F.S. Stephens.

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    JOURNAL DE PHYSIQUE CoZZoque CZO, suppldment au n012, Tom 41, ddcembre 1980, page C10-1 F.S. Stephens. NucZear Science Division, kwrence BerkeZey Laboratory, University of CaZifomzia, BerkeZey, CA

  7. Supplemental Information for "Regional to global assessments of phytoplankton dynamics from the SeaWiFS mission" by D.A. Siegel and others.

    E-Print Network [OSTI]

    Siegel, David A.

    . This water-leaving radiance, Lw(), is solar radiation that penetrated the ocean surface, interacted the SeaWiFS mission" by D.A. Siegel and others. Satellite Ocean Color Data Processing: Ocean color sensors are designed to measure the spectral distribution of visible radiation upwelling from beneath the ocean surface

  8. Modeling green fluorescent protein transcription, translation and modification as a method to obtain NF-kappaB activation profiles

    E-Print Network [OSTI]

    Laible, Allyson Marie

    2009-05-15T23:59:59.000Z

    that fluorescence increases up to 24 hours after an initial delay of approximately four hours. The fluorescence data was also used to develop a model describing significant events leading to NF-?B activation and GFP expression. In addition, a model describing...

  9. TCR and CD28 activate the transcription factor NF- B in T-cells viadistinct adaptor signaling complexes

    E-Print Network [OSTI]

    Thaker, Youg Raj; Schneider, Helga; Rudd, Christopher E.

    2014-10-23T23:59:59.000Z

    of NF-{kappa}B activation in T cells via association of the adapter proteins ADAP and CARMA1. Science 2007;316:754–8. [30] Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, et al. Phosphorylation of the CARMA1 linker...

  10. Enhancement of CD8+ T-cell memory by removal of a vaccinia virus NF-?B inhibitor

    E-Print Network [OSTI]

    Ren, Hongwei; Ferguson, Brian J.; de Motes, Carlos Maluquer; Sumner, Rebecca P.; Harman, Laura; Smith, Geoffrey L.

    2014-11-07T23:59:59.000Z

    induction of NF-kappaB activation via an ERK2 pathway in virus-infected human embryonic kidney cells. J Virol 2006;80(17):8676-85. 63. Harte MT, Haga IR, Maloney G, et al. The poxvirus protein A52R targets Toll-like receptor signaling complexes...

  11. Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-{kappa}B-mediated survival signaling

    SciTech Connect (OSTI)

    Leskinen, Markus J. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Heikkilae, Hanna M. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Speer, Mei Y. [Bioengineering Department, University of Washington, Seattle, WA 98195 (United States); Hakala, Jukka K. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Laine, Mika [Department of Medicine, Helsinki University Central Hospital and Minerva Institute for Medical Research, Helsinki (Finland); Kovanen, Petri T. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland); Lindstedt, Ken A. [Wihuri Research Institute, Kalliolinnantie 4, FI-00140 Helsinki (Finland)]. E-mail: ken.lindstedt@wri.fi

    2006-05-01T23:59:59.000Z

    Chymase released from activated mast cells induces apoptosis of vascular smooth muscle cells (SMCs) in vitro by degrading the pericellular matrix component fibronectin, so causing disruption of focal adhesion complexes and Akt dephosphorylation, which are necessary for cell adhesion and survival. However, the molecular mechanisms of chymase-mediated apoptosis downstream of Akt have remained elusive. Here, we show by means of RT-PCR, Western blotting, EMSA, immunocytochemistry and confocal microscopy, that chymase induces SMC apoptosis by disrupting NF-{kappa}B-mediated survival signaling. Following chymase treatment, the translocation of active NF-{kappa}B/p65 to the nucleus was partly abolished and the amount of nuclear p65 was reduced. Pretreatment of SMCs with chymase also inhibited LPS- and IL-1{beta}-induced nuclear translocation of p65. The chymase-induced degradation of p65 was mediated by active caspases. Loss of NF-{kappa}B-mediated transactivation resulted in downregulation of bcl-2 mRNA and protein expression, leading to mitochondrial swelling and release of cytochrome c. The apoptotic process involved activation of both caspase 9 and caspase 8. The results reveal that, by disrupting the NF-{kappa}B-mediated survival-signaling pathway, activated chymase-secreting mast cells can mediate apoptosis of cultured arterial SMCs. Since activated mast cells colocalize with apoptotic SMCs in vulnerable areas of human atherosclerotic plaques, they may participate in the weakening and rupture of atherosclerotic plaques.

  12. Journal of Membrane Science 256 (2005) 134142 Characterization of novel acid-stable NF membranes before and after

    E-Print Network [OSTI]

    Freger, Viatcheslav "Slava"

    2005-01-01T23:59:59.000Z

    to hot 20% sulfuric acid solutions for various times. Swelling and morphological changes measured Nanofiltration (NF) membranes represent a class of mem- branes with capabilities to selectively separate low- sulfone, which support an ultra-thin selective layer a few tens to a few hundred of nanometers thick

  13. D-Dbar Mixing in the Standard Model and Beyond from Nf=2 Twisted Mass QCD

    E-Print Network [OSTI]

    N. Carrasco; M. Ciuchini; P. Dimopoulos; R. Frezzotti; V. Gimenez; V. Lubicz; G. C. Rossi; F. Sanfilippo; L. Silvestrini; S. Simula; C. Tarantino

    2014-06-13T23:59:59.000Z

    We present the first unquenched lattice QCD results for the bag parameters controlling the short distance contribution to D meson oscillations in the Standard Model and beyond. We have used the gauge configurations produced by the European Twisted Mass Collaboration with Nf = 2 dynamical quarks, at four lattice spacings and light meson masses in the range 280-500 MeV. Renormalization is carried out non-perturbatively with the RI-MOM method. The bag-parameter results have been used to constrain New Physics effects in D-Dbar mixing, to put a lower bound to the generic New Physics scale and to constrain off-diagonal squark mass terms for TeV-scale Supersymmetry.

  14. Kaon semileptonic vector form factor with $N_f=2+1+1$ Twisted Mass fermions

    E-Print Network [OSTI]

    Nuria Carrasco; Paolo Lami; Vittorio Lubicz; Eleonora Picca; Lorenzo Riggio; Silvano Simula; Cecilia Tarantino

    2014-10-27T23:59:59.000Z

    We investigate the vector form factor relevant for the $K_{\\ell 3}$ semileptonic decay using maximally twisted-mass fermions with 4 dynamical flavours ($N_f=2+1+1$). Our simulations feature pion masses ranging from $210$ MeV to approximately $450$ MeV and lattice spacing values as small as $0.06$fm. Our main result for the vector form factor at zero 4-momentum transfer is $f_+(0)=0.9683(65)$ where the uncertainty is both statistical and systematic. By combining our result with the experimental value of $f_+(0)|V_{us}|$ we obtain $|V_{us}|=0.2234(16)$, which satisfies the unitarity constraint of the Standard Model at the permille level.

  15. Ascorbic acid suppresses endotoxemia and NF-?B signaling cascade in alcoholic liver fibrosis in guinea pigs: A mechanistic approach

    SciTech Connect (OSTI)

    Abhilash, P.A.; Harikrishnan, R.; Indira, M., E-mail: indiramadambath@gmail.com

    2014-01-15T23:59:59.000Z

    Alcohol consumption increases the small intestinal bacterial overgrowth (SIBO) and intestinal permeability of endotoxin. The endotoxin mediated inflammatory signaling plays a major role in alcoholic liver fibrosis. We evaluated the effect of ascorbic acid (AA), silymarin and alcohol abstention on the alcohol induced endotoxemia and NF-?B activation cascade pathway in guinea pigs (Cavia porcellus). Guinea pigs were administered ethanol at a daily dose of 4 g/kg b.wt for 90 days. After 90 days, ethanol administration was stopped. The ethanol treated animals were divided into abstention, silymarin (250 mg/kg b.wt) and AA (250 mg/kg b.wt) supplemented groups and maintained for 30 days. The SIBO, intestinal permeability and endotoxin were significantly increased in the ethanol group. The mRNA expressions of intestinal proteins claudin, occludin and zona occludens-1 were significantly decreased in ethanol group. The mRNA levels of inflammatory receptors, activity of IKK? and the protein expressions of phospho-I?B?, NF-?B, TNF-?, TGF-?{sub 1} and IL-6 were also altered in ethanol group. The expressions of fibrosis markers ?-SMA, ?{sub 1} (I) collagen and sirius red staining in the liver revealed the induction of fibrosis. But the supplementation of AA could induce greater reduction of ethanol induced SIBO, intestinal barrier defects, NF-?B activation and liver fibrosis than silymarin. The possible mechanism may be the inhibitory effect of AA on SIBO, intestinal barrier defect and IKK?, which decreased the activation of NF-?B and synthesis of cytokines. This might have led to suppression of HSCs activation and liver fibrosis. - Highlights: • Alcohol increases intestinal bacterial overgrowth and permeability of endotoxin. • Endotoxin mediated inflammation plays a major role in alcoholic liver fibrosis. • Ascorbic acid reduces endotoxemia, NF-?B activation and proinflammatory cytokines. • AA's action is by inhibition of SIBO, IKK? and alteration of intestinal permeability. • This might have led to suppression of HSCs activation and liver fibrosis.

  16. NF-kB activity-dependent P-selectin involved in ox-LDL-induced foam cell formation in U937 cell

    SciTech Connect (OSTI)

    Wang, Yi, E-mail: wangyi2004a@126.com [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China)] [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China); Wang, Xiang; Sun, Minghui; Zhang, Zhenyu; Cao, Heng; Chen, Xiaoqing [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China)] [Department of Cardiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080 (China)

    2011-08-05T23:59:59.000Z

    Highlights: {yields} Ox-LDL induced foam cell formation in the human U937 promonocytic cell line in a dose- and time-dependent manner. {yields} Ox-LDL induced expression of P-selectin through degradation of IkBa and augment of NF-kB activity and protein level during macrophage-derived foam cell formation. {yields} P-selectin and NF-kB may be identified as pivotal regulators of ox-LDL-induced foam cell formation. {yields} Therapy based on the inhibition of P-selectin and NF-kB may complement conventional treatments to prevent atherosclerosis. -- Abstract: Oxidized low-density lipoprotein (ox-LDL) plays a critical role in regulation of atherosclerosis. However, little is known about the role of Nuclear factor kB (NF-kB) activity-dependent P-selectin in ox-LDL-induced foam cell formation during atherosclerosis. In this study, we first investigated ox-LDL induced foam cell formation in the human U937 promonocytic cell line in a dose- and time-dependent manner. Treatment of U937 cells with ox-LDL increased lipid accumulation as well as intracellular cholesterol content. Next, a comparative analysis of gene expression profiling using cDNA microarray and Real-time-PCR indicated that ox-LDL exposure induced, in three treated groups, an extremely marked increase in the mRNA level of P-selectin. Protein levels of P-selectin and its upstream regulators IkBa and NF-kB showed that NF-kB pathway is involved in the ox-LDL-induced foam cell formation. Finally, overexpression of NF-kB significantly accelerated, whereas, inhibition of NF-kB with siRNA remarkably attenuated ox-LDL-induced macrophage-derived foam cell formation. It was concluded that the activity of NF-kB is augmented during macrophage-derived foam cell formation. Activation of NF-kB increased, whereas, inhibition of NF-kB decreased ox-LDL-induced P-selectin expression and lipid accumulation in macrophages, suggesting ox-LDL induced expression of P-selectin through degradation of IkBa and activation of NF-kB in the regulation of foam cell formation.

  17. Thermal Reactions of Uranium Metal, UO2, U3O8, UF4, and UO2F2 with NF3 to Produce UF6

    SciTech Connect (OSTI)

    McNamara, Bruce K.; Scheele, Randall D.; Kozelisky, Anne E.; Edwards, Matthew K.

    2009-11-01T23:59:59.000Z

    he objective of this paper is to demonstrate that NF3 fluorinates uranium metal, UO2, UF4, UO3, U3O8, and UO2F2•2H2O to produce the volatile UF6 at temperatures between 100 and 500?C. Thermogravimetric reaction profiles are described that reflect changes in the uranium oxidation state and discrete chemical speciation. Differences in the onset temperatures for each system indicate that NF3-substrate interactions are important for the temperature at which NF3 reacts: U metal > UO3 > UO2 > UO2F2 > UF4 and in fact may indicate different fluorination mechanisms for these various substrates. These studies demonstrate that NF3 is a potential replacement fluorinating agent in the existing nuclear fuel cycle and in oft-proposed actinide volatility reprocessing.

  18. Absorption of a single 500 fs laser pulse at the surface of fused silica: Energy balance and ablation efficiency

    SciTech Connect (OSTI)

    Varkentina, N.; Sanner, N.; Lebugle, M.; Sentis, M.; Utéza, O. [Aix-Marseille Université, CNRS, LP3 UMR 7341, 13288 Marseille (France)] [Aix-Marseille Université, CNRS, LP3 UMR 7341, 13288 Marseille (France)

    2013-11-07T23:59:59.000Z

    Ablation of fused silica by a single femtosecond laser pulse of 500 fs pulse duration is investigated from the perspective of efficiency of incident photons to remove matter. We measure the reflected and transmitted fractions of the incident pulse energy as a function of fluence, allowing us to recover the evolution of absorption at the material surface. At the ablation threshold fluence, 25% of incident energy is absorbed. At high fluences, this ratio saturates around 70% due to the appearance of a self-triggered plasma mirror (or shielding) effect. By using the energy balance retrieved experimentally and measurements of the ablated volume, we show that the amount of absorbed energy is far above the bonding energy of fused silica at rest and also above the energy barrier to ablate the material under non-equilibrium thermodynamic conditions. Our results emphasize the crucial role of transient plasma properties during the laser pulse and suggest that the major part of the absorbed energy has been used to heat the plasma formed at the surface of the material. A fluence range yielding an efficient and high quality ablation is also defined, which makes the results relevant for femtosecond micromachining processes.

  19. High-precision Distribution of Highly-stable Optical Pulse Trains with Sub-10-fs Timing Jitter

    E-Print Network [OSTI]

    Ning, B; Hou, D; Wu, J T; Li, Z B; Zhao, J Y

    2014-01-01T23:59:59.000Z

    High-precision optical pulse trains distribution via fibre links has made huge impacts in many fields. In most published works, the accuracies are still fundamentally limited by some unavoidable noises, such as thermal and shot noise from conventional photodiodes, thermal noise from mixers. Here, we demonstrate a new high-precision timing distribution system by using highly-precision phase detector to overcome the limitations. Instead of using photodiodes and microwave mixers, we use several fibre Sagnac-loop-based optical-microwave phase detectors to realize optical-electrical conversion and phase measurements, for suppressing the noises and achieving ultra-high accuracy. A 10-km fibre link distribution experiment shows our system provides a residual instability at the level of 4.6*10-15@1-s and 6.1*10-18@10000-s, with an integrated timing jitter as low as 3.8 fs in a bandwidth of 1 Hz to 100 KHz. This low instability and timing jitter makes it possible that our system can be used in the optical clock distri...

  20. Tunable sub-20 fs pulses from a 500 kHz OPCPA with 15 W average power based on an all-ytterbium laser

    E-Print Network [OSTI]

    Puppin, Michele; Prochnow, Oliver; Ahrens, Jan; Binhammer, Thomas; Morgner, Uwe; Krenz, Marcel; Wolf, Martin; Ernstorfer, Ralph

    2014-01-01T23:59:59.000Z

    An optical parametric chirped pulse amplifier fully based on Yb lasers at 500 kHz is described. Passive optical-synchronization is achieved between a fiber laser-pumped white-light and a 515 nm pump produced with a 200 W picosecond Yb:YAG InnoSlab amplifier. An output power up to 19.7 W with long-term stability of 0.3% is demonstrated for wavelength tunable pulses between 680 nm and 900 nm and spectral stability of 0.2%; 16.5 W can be achieved with a bandwidth supporting 5.4 fs pulses. We demonstrate compression of 30 microjoule pulses to sub-20 fs duration with a prism compressor, suitable for high harmonic generation.

  1. 1 Managed by UT-Battelle for the U.S. Department of Energy NF/IDS Hg Vessel Layout 30 Jun 09

    E-Print Network [OSTI]

    McDonald, Kirk

    1 Managed by UT-Battelle for the U.S. Department of Energy NF/IDS Hg Vessel Layout 30 Jun 09 Cryostat 2 Front Drain Mercury Vessel Concept Matthew F. Glisson Van Graves #12;2 Managed by UT-Battelle;3 Managed by UT-Battelle for the U.S. Department of Energy NF/IDS Hg Vessel Layout 30 Jun 09 Cross Section

  2. Nmero Nome 1T 2T R1T R2T E AC NF 42200 Armando Dias

    E-Print Network [OSTI]

    Baia, Margarida

    Sheet1 Page 1 Número Nome 1T 2T R1T R2T E AC NF 42200 Armando Dias 53515 Jorge Branco 55774 João 70100 Catarina Ferreira 70146 Mariana Castro 70364 Nuno Gaspar 70524 António Grego 10 2 5 70934 João.2 2 15 78167 Afonso Sarmento 13.8 8.3 7.6 2 12 78175 Carlos Martins 14.3 12.6 11 2 14 78183 Ana

  3. Sulforaphane protects against cytokine- and streptozotocin-induced {beta}-cell damage by suppressing the NF-{kappa}B pathway

    SciTech Connect (OSTI)

    Song, Mi-Young; Kim, Eun-Kyung [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, 561-756 (Korea, Republic of); Moon, Woo-Sung [Department of Pathology, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, 561-756 (Korea, Republic of); Park, Jin-Woo [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, 561-756 (Korea, Republic of); Kim, Hyung-Jin; So, Hong-Seob; Park, Raekil [Vestibulocochlear System Research Center, College of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749 (Korea, Republic of); Kwon, Kang-Beom [Department of Physiology, School of Oriental Medicine, College of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749 (Korea, Republic of); Vestibulocochlear System Research Center, College of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749 (Korea, Republic of)], E-mail: desson@wonkwang.ac.kr; Park, Byung-Hyun [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, 561-756 (Korea, Republic of)], E-mail: bhpark@chonbuk.ac.kr

    2009-02-15T23:59:59.000Z

    Sulforaphane (SFN) is an indirect antioxidant that protects animal tissues from chemical or biological insults by stimulating the expression of several NF-E2-related factor-2 (Nrf2)-regulated phase 2 enzymes. Treatment of RINm5F insulinoma cells with SFN increases Nrf2 nuclear translocation and expression of phase 2 enzymes. In this study, we investigated whether the activation of Nrf2 by SFN treatment or ectopic overexpression of Nrf2 inhibited cytokine-induced {beta}-cell damage. Treatment of RIN cells with IL-1{beta} and IFN-{gamma} induced {beta}-cell damage through a NF-{kappa}B-dependent signaling pathway. Activation of Nrf2 by treatment with SFN and induction of Nrf2 overexpression by transfection with Nrf2 prevented cytokine toxicity. The mechanism by which Nrf2 activation inhibited NF-{kappa}B-dependent cell death signals appeared to involve the reduction of oxidative stress, as demonstrated by the inhibition of cytokine-induced H{sub 2}O{sub 2} production. The protective effect of SFN was further demonstrated by the restoration of normal insulin secreting responses to glucose in cytokine-treated rat pancreatic islets. Furthermore, pretreatment with SFN blocked the development of type 1 diabetes in streptozotocin-treated mice.

  4. Etching of UO{sub 2} in NF{sub 3} RF Plasma Glow Discharge

    SciTech Connect (OSTI)

    John M. Veilleux

    1999-08-01T23:59:59.000Z

    A series of room temperature, low pressure (10.8 to 40 Pa), low power (25 to 210 W) RF plasma glow discharge experiments with UO{sub 2} were conducted to demonstrate that plasma treatment is a viable method for decontaminating UO{sub 2} from stainless steel substrates. Experiments were conducted using NF{sub 3} gas to decontaminate depleted uranium dioxide from stainless-steel substrates. Depleted UO{sub 2} samples each containing 129.4 Bq were prepared from 100 microliter solutions of uranyl nitrate hexahydrate solution. The amorphous UO{sub 2} in the samples had a relatively low density of 4.8 gm/cm{sub 3}. Counting of the depleted UO{sub 2} on the substrate following plasma immersion was performed using liquid scintillation counting with alpha/beta discrimination due to the presence of confounding beta emitting daughter products, {sup 234}Th and {sup 234}Pa. The alpha emission peak from each sample was integrated using a gaussian and first order polynomial fit to improve quantification. The uncertainties in the experimental measurement of the etched material were estimated at about {+-} 2%. Results demonstrated that UO{sub 2} can be completely removed from stainless-steel substrates after several minutes processing at under 200 W. At 180 W and 32.7 Pa gas pressure, over 99% of all UO{sub 2} in the samples was removed in just 17 minutes. The initial etch rate in the experiments ranged from 0.2 to 7.4 {micro}m/min. Etching increased with the plasma absorbed power and feed gas pressure in the range of 10.8 to 40 Pa. A different pressure effect on UO{sub 2} etching was also noted below 50 W in which etching increased up to a maximum pressure, {approximately}23 Pa, then decreased with further increases in pressure.

  5. Renormalization of local quark-bilinear operators for Nf=3 flavors of SLiNC fermions

    E-Print Network [OSTI]

    M. Constantinou; R. Horsley; H. Panagopoulos; H. Perlt; P. E. L. Rakow; G. Schierholz; A. Schiller; J. M. Zanotti

    2014-08-26T23:59:59.000Z

    The renormalization factors of local quark-bilinear operators are computed non-perturbatively for $N_f=3$ flavors of SLiNC fermions, with emphasis on the various procedures for the chiral and continuum extrapolations. The simulations are performed at a lattice spacing $a=0.074$ fm, and for five values of the pion mass in the range of 290-465 MeV, allowing a safe and stable chiral extrapolation. Emphasis is given in the subtraction of the well-known pion pole which affects the renormalization factor of the pseudoscalar current. We also compute the inverse propagator and the Green's functions of the local bilinears to one loop in perturbation theory. We investigate lattice artifacts by computing them perturbatively to second order as well as to all orders in the lattice spacing. The renormalization conditions are defined in the RI$'$-MOM scheme, for both the perturbative and non-perturbative results. The renormalization factors, obtained at different values of the renormalization scale, are translated to the ${\\bar{\\rm MS}}$ scheme and are evolved perturbatively to 2 GeV. Any residual dependence on the initial renormalization scale is eliminated by an extrapolation to the continuum limit. We also study the various sources of systematic errors. Particular care is taken in correcting the non-perturbative estimates by subtracting lattice artifacts computed to one loop perturbation theory using the same action. We test two different methods, by subtracting either the ${\\cal O}(g^2\\,a^2)$ contributions, or the complete (all orders in $a$) one-loop lattice artifacts.

  6. Mercury FS.pdf

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011 Strategic2 OPAM Flash2011-12Approvedof6,Projects38, 1)QuestionnairesMentor Profile

  7. Determination of c_sw in N_f=3+1 Lattice QCD with massive Wilson fermions

    E-Print Network [OSTI]

    Patrick Fritzsch; Rainer Sommer; Felix Stollenwerk; Ulli Wolff

    2015-01-27T23:59:59.000Z

    We develop a strategy for the non-perturbative determination of the O(a)-improvement coefficient c_sw for Wilson fermions with massive sea quarks. The improvement condition is defined via the PCAC relation in the Schr\\"odinger functional. It is imposed along a line of constant physics designed to be close to the correct mass of the charm quark. The numerical work uses the tree-level improved L\\"uscher-Weisz gauge action in N_f=3+1 Lattice QCD.

  8. A (P)HMC algorithm for N_f = 2 + 1 + 1 flavours of twisted mass fermions

    E-Print Network [OSTI]

    T. Chiarappa; R. Frezzotti; C. Urbach

    2005-09-27T23:59:59.000Z

    We present a detailed design of a (P)HMC simulation algorithm for N_f = 2 + 1 + 1 maximally twisted Wilson quark flavours. The algorithm retains even/odd and mass-shift preconditionings combined with multiple Molecular Dynamics time scales for both the light mass degenerate, u and d, quarks and the heavy mass non-degenerate, s and c, quarks. Various non-standard aspects of the algorithm are discussed, among which those connected to the use of a polynomial approximation for the inverse (square root of the squared) Dirac matrix in the s and c quark sector.

  9. Natural Proteasome Inhibitor Celastrol Suppresses Androgen-Independent Prostate Cancer Progression by Modulating Apoptotic Proteins and NF-kappaB

    E-Print Network [OSTI]

    Dai, Yao; Jeffrey, Tang; Wenhua, Xiaojie; Meng, Yang; Burstein, Ezra; Lawrence, Theodore S.; Xu, Liang

    2010-12-10T23:59:59.000Z

    Apoptotic Proteins and NF-kappaB. PLoS ONE 5(12): e14153. doi:10.1371/journal.pone.0014153 Editor: Gen Sheng Wu, Wayne State University, United States of America Received July 10, 2010; Accepted November 10, 2010; Published December 10, 2010 Copyright: #2... through a University of Michigan Cancer Center Support Grant [5 P30 CA46592]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared...

  10. NF-{kappa}B signaling is activated and confers resistance to apoptosis in three-dimensionally cultured EGFR-mutant lung adenocarcinoma cells

    SciTech Connect (OSTI)

    Sakuma, Yuji, E-mail: ysakuma@gancen.asahi.yokohama.jp [Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama (Japan)] [Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama (Japan); Yamazaki, Yukiko; Nakamura, Yoshiyasu; Yoshihara, Mitsuyo; Matsukuma, Shoichi; Koizume, Shiro; Miyagi, Yohei [Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama (Japan)] [Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama (Japan)

    2012-07-13T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer EGFR-mutant cells in 3D culture resist EGFR inhibition compared with suspended cells. Black-Right-Pointing-Pointer Degradation of I{kappa}B and activation of NF-{kappa}B are observed in 3D-cultured cells. Black-Right-Pointing-Pointer Inhibiting NF-{kappa}B enhances the efficacy of the EGFR inhibitor in 3D-cultured cells. -- Abstract: Epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma cells in suspension undergo apoptosis to a greater extent than adherent cells in a monolayer when EGFR autophosphorylation is inhibited by EGFR tyrosine kinase inhibitors (TKIs). This suggests that cell adhesion to a culture dish may activate an anti-apoptotic signaling pathway other than the EGFR pathway. Since the microenvironment of cells cultured in a monolayer are substantially different to that of cells existing in three-dimension (3D) in vivo, we assessed whether two EGFR-mutant lung adenocarcinoma cell lines, HCC827 and H1975, were more resistant to EGFR TKI-induced apoptosis when cultured in a 3D extracellular matrix (ECM) as compared with in suspension. The ECM-adherent EGFR-mutant cells in 3D were significantly less sensitive to treatment with WZ4002, an EGFR TKI, than the suspended cells. Further, a marked degradation of I{kappa}B{alpha}, the inhibitor of nuclear factor (NF)-{kappa}B, was observed only in the 3D-cultured cells, leading to an increase in the activation of NF-{kappa}B. Moreover, the inhibition of NF-{kappa}B with pharmacological inhibitors enhanced EGFR TKI-induced apoptosis in 3D-cultured EGFR-mutant cells. These results suggest that inhibition of NF-{kappa}B signaling would render ECM-adherent EGFR-mutant lung adenocarcinoma cells in vivo more susceptible to EGFR TKI-induced cell death.

  11. Determination of the running coupling constant $?_s$ for Nf=2+1 QCD with the Schroedinger functional scheme

    E-Print Network [OSTI]

    Yusuke Taniguchi; for the PACS-CS collaboration

    2009-10-27T23:59:59.000Z

    We present an evaluation of the running coupling constant and the quark mass renormalization factor for $N_f=2+1$ QCD. The Schr\\"odinger functional scheme is used as the intermediate scheme to carry out non-perturbative running from the low energy region, where physical input is introduced, to deep in the high energy perturbative region, where conversion to the ${\\ovl{\\rm MS}}$ scheme is safely performed. For numerical simulations we adopted Iwasaki gauge action and non-perturbatively improved Wilson fermion action with the clover term. Seven renormalization scales are used to cover from low to high energy region and three lattice spacings to take the continuum limit at each scale. Physical inputs are introduced from the previous $N_f=2+1$ simulation of the CP-PACS/JL-QCD collaboration, which covered the up-down quark mass range heavier than $m_\\pi\\sim 500$ MeV, and that of PACS-CS collaboration for much lighter quark masses down to $m_\\pi=155$ MeV.

  12. Angiotensin II modulates interleukin-1{beta}-induced inflammatory gene expression in vascular smooth muscle cells via interfering with ERK-NF-{kappa}B crosstalk

    SciTech Connect (OSTI)

    Xu, Shanqin [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States)] [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States); Zhi, Hui [Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States)] [Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States); Hou, Xiuyun [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States)] [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States); Jiang, Bingbing, E-mail: bjiang1@rics.bwh.harvard.edu [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States) [Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA (United States); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (United States)

    2011-07-08T23:59:59.000Z

    Highlights: {yields} We examine how angiotensin II modulates ERK-NF-{kappa}B crosstalk and gene expression. {yields} Angiotensin II suppresses IL-1{beta}-induced prolonged ERK and NF-{kappa}B activation. {yields} ERK-RSK1 signaling is required for IL-1{beta}-induced prolonged NF-{kappa}B activation. {yields} Angiotensin II modulates NF-{kappa}B responsive genes via regulating ERK-NF-{kappa}B crosstalk. {yields} ERK-NF-{kappa}B crosstalk is a novel mechanism regulating inflammatory gene expression. -- Abstract: Angiotensin II is implicated in cardiovascular diseases, which is associated with a role in increasing vascular inflammation. The present study investigated how angiotensin II modulates vascular inflammatory signaling and expression of inducible nitric oxide synthase (iNOS) and vascular cell adhesion molecule (VCAM)-1. In cultured rat aortic vascular smooth muscle cells (VSMCs), angiotensin II suppressed interleukin-1{beta}-induced prolonged phosphorylation of extracellular signal-regulated kinase (ERK) and ribosomal S6 kinase (RSK)-1, and nuclear translocation of nuclear factor (NF)-{kappa}B, leading to decreased iNOS but enhanced VCAM-1 expression, associated with an up-regulation of mitogen-activated protein kinase phosphatase-1 expression. Knock-down of RSK1 selectively down regulated interleukin-1{beta}-induced iNOS expression without influencing VCAM-1 expression. In vivo experiments showed that interleukin-1{beta}, iNOS, and VCAM-1 expression were detectable in the aortic arches of both wild-type and apolipoprotein E-deficient (ApoE{sup -/-}) mice. VCAM-1 and iNOS expression were higher in ApoE{sup -/-} than in wild type mouse aortic arches. Angiotensin II infusion (3.2 mg/kg/day, for 6 days, via subcutaneous osmotic pump) in ApoE{sup -/-} mice enhanced endothelial and adventitial VCAM-1 and iNOS expression, but reduced medial smooth muscle iNOS expression associated with reduced phosphorylation of ERK and RSK-1. These results indicate that angiotensin II can differentially modulate inflammatory gene expression in aortic smooth muscle cells through influencing ERK-NF-{kappa}B crosstalk, which may contribute to angiotensin II-induced inflammatory disorders related to cardiovascular diseases.

  13. Apolipoprotein E inhibits osteoclast differentiation via regulation of c-Fos, NFATc1 and NF-?B

    SciTech Connect (OSTI)

    Kim, Woo-Shin; Kim, Hyung Joon; Lee, Zang Hee [Department of Cell and Developmental Biology, BK21 Program and Dental Research Institute, Seoul National University, 28 Yeongon-Dong, Chongno-Gu, Seoul 110-749 (Korea, Republic of); Lee, Youngkyun [Department of Biochemistry, School of Dentistry, Kyungpook National University, Daegu 700-422 (Korea, Republic of); Kim, Hong-Hee, E-mail: hhbkim@snu.ac.kr [Department of Cell and Developmental Biology, BK21 Program and Dental Research Institute, Seoul National University, 28 Yeongon-Dong, Chongno-Gu, Seoul 110-749 (Korea, Republic of)

    2013-02-15T23:59:59.000Z

    Apolipoprotein E (ApoE) plays a major role in the transport and metabolism of lipid. Other functions of ApoE include modulation of innate and adaptive immune responses. The expression of ApoE in osteoblasts and its relevance with bone formation have also been reported. However, the effect of ApoE on osteoclasts has not yet been examined. Here, we investigated the role of ApoE in osteoclast differentiation using bone marrow-derived macrophages (BMMs) and RAW264.7 cells. We found a down-regulation of ApoE gene expression during osteoclastic differentiation of those cells. Overexpression of ApoE in BMMs and RAW264.7 cells significantly blocked the induction of c-Fos and nuclear factor of activated T cell c1 (NFATc1), transcription factors critical for expression of osteoclast marker genes, by receptor activator of nuclear factor ?B ligand (RANKL), the osteoclast differentiation factor. ApoE inhibited osteoclast differentiation, as measured by decreased number of tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cells (MNCs). In addition, ApoE reduced the expression of dendritic cell-specific transmembrane protein (DC-STAMP) and ATPase, H{sup +} transporting, lysosomal 38 kDa, V0 subunit d2 (ATP6v0d2), genes involved in cell–cell fusion during osteoclastogenesis. Knock-down of ApoE using a specific siRNA promoted the RANKL-mediated induction of osteoclast differentiation. While ApoE did not affect the activation of ERK, JNK, and p38 MAPK signaling pathways by RANKL, the phosphorylation of p65 trans-activation domain on serine 536 and transcription activity of NF-?B were reduced by ApoE overexpression. These findings suggest that ApoE plays an inhibitory role in osteoclast differentiation via the suppression of RANKL-dependent activation of NF-?B and induction of c-Fos and NFATc1. - Highlights: ? Apolipoprotein E (ApoE) significantly inhibited osteoclast differentiation and activation of NF-?B. ? ApoE decreased the induction of osteoclast marker genes such as c-Fos, NFATc1, TRAP, DC-STAMP and Cathepsin K. ? ApoE reduced number of TRAP-positive multinuclear cells. ? Exogenous ApoE inhibits osteoclast formation by reduction of crucial factor of osteoclast differentiation. ? knock-down of ApoE promoted the RANKL-mediated induction of osteoclast differentiation.

  14. GRP94/gp96 Elicits ERK Activation in Murine Macrophages A ROLE FOR ENDOTOXIN CONTAMINATION IN NF-B ACTIVATION AND NITRIC OXIDE PRODUCTION*

    E-Print Network [OSTI]

    Nicchitta, Chris

    GRP94/gp96 Elicits ERK Activation in Murine Macrophages A ROLE FOR ENDOTOXIN CONTAMINATION IN NF- B signaling and ni- tric oxide production, as well as the MAP kinase p38, JNK, and ERK signaling cascades a marked increase in ERK phosphorylation at protein concentrations as low as 2 g/ml. These results

  15. Differential Effects of ?-catenin and NF-?B Interplay in the Regulation of Cell Proliferation, Inflammation and Tumorigenesis in Response to Bacterial Infection

    E-Print Network [OSTI]

    Chandrakesan, Parthasarathy; Jakkula, Laxmi Uma Maheswar Rao; Ahmed, Ishfaq; Roy, Badal; Anant, Shrikant; Umar, Shahid

    2013-11-21T23:59:59.000Z

    Both ?-catenin and NF-?B have been implicated in our laboratory as candidate factors in driving proliferation in an in vivo model of Citrobacter rodentium (CR)-induced colonic crypt hyper-proliferation and hyperplasia. Herein, we test the hypothesis...

  16. Spontaneous transition of core radial electric field driven by magnetic islands in the H-1NF heliac

    SciTech Connect (OSTI)

    Kumar, S. T. A. [University of Wisconsin, Madison; Blackwell, B. D. [Australian National University, Canberra, Australia; Howard, J. [Australian National University, Canberra, Australia; Harris, J. H. [Oak Ridge National Laboratory (ORNL)

    2011-01-01T23:59:59.000Z

    This paper reports an experimental observation of spontaneous transition of the core radial electric field to a large positive value (E(r) similar to 5 kV m(-1)), with a strong electric-field shear (similar to 700 kV m(-2)) in a low temperature (T(e) similar to 10 eV) radio frequency generated argon plasma in the H-1NF heliac stellarator. The transition, which seems to be driven by a spontaneous excitation of m = 2 magnetic islands near the core, is associated with a localized increase in the plasma density and excitation of coherent low frequency (similar to 3 kHz) oscillations possibly due to unstable E(r) shear driven modes. Evidence suggests development of the core electron-root scenario, which previously has been observed only at high temperature electron cyclotron heated plasmas.

  17. Absolute frequency measurements of 85Rb nF7/2 Rydberg states using purely optical detection

    E-Print Network [OSTI]

    L. A. M. Johnson; H. O. Majeed; B. Sanguinetti; Th. Becker; B. T. H. Varcoe

    2010-02-16T23:59:59.000Z

    A three-step laser excitation scheme is used to make absolute frequency measurements of highly excited nF7/2 Rydberg states in 85Rb for principal quantum numbers n=33-100. This work demonstrates the first absolute frequency measurements of rubidium Rydberg levels using a purely optical detection scheme. The Rydberg states are excited in a heated Rb vapour cell and Doppler free signals are detected via purely optical means. All of the frequency measurements are made using a wavemeter which is calibrated against a GPS disciplined self-referenced optical frequency comb. We find that the measured levels have a very high frequency stability, and are especially robust to electric fields. The apparatus has allowed measurements of the states to an accuracy of 8.0MHz. The new measurements are analysed by extracting the modified Rydberg-Ritz series parameters.

  18. Magnetic susceptibility and equation of state of N_f = 2+1 QCD with physical quark masses

    E-Print Network [OSTI]

    Claudio Bonati; Massimo D'Elia; Marco Mariti; Francesco Negro; Francesco Sanfilippo

    2014-05-13T23:59:59.000Z

    We determine the free energy of strongly interacting matter as a function of an applied constant and uniform magnetic field. We consider N_f = 2+1 QCD with physical quark masses, discretized on a lattice by stout improved staggered fermions and a tree level improved Symanzik pure gauge action, and explore three different lattice spacings. For magnetic fields of the order of those produced in non-central heavy ion collisions (eB ~ 0.1 GeV^2) strongly interacting matter behaves like a medium with a linear response, and is paramagnetic both above and below the deconfinement transition, with a susceptibility which steeply rises in the deconfined phase. We compute the equation of state, showing that the relative increase in the pressure due to the magnetic field gets larger around the transition, and of the order of 10 % for eB ~ 0.1 GeV^2.

  19. Metastatic function of BMP-2 in gastric cancer cells: The role of PI3K/AKT, MAPK, the NF-{kappa}B pathway, and MMP-9 expression

    SciTech Connect (OSTI)

    Kang, Myoung Hee [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Oh, Sang Cheul [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Lee, Hyun Joo [Department of Pathology, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Department of Pathology, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Kang, Han Na; Kim, Jung Lim [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Kim, Jun Suk [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)] [Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of); Yoo, Young A., E-mail: ydanbi@korea.ac.kr [Brain Korea 21 Program for Biomedical Science, Korea University College of Medicine, Korea University, Seoul 136-705 (Korea, Republic of)

    2011-07-15T23:59:59.000Z

    Bone morphogenetic proteins (BMPs) have been implicated in tumorigenesis and metastatic progression in various types of cancer cells, but the role and cellular mechanism in the invasive phenotype of gastric cancer cells is not known. Herein, we determined the roles of phosphoinositide 3-kinase (PI3K)/AKT, extracellular signal-regulated protein kinase (ERK), nuclear factor (NF)-{kappa}B, and matrix metalloproteinase (MMP) expression in BMP-2-mediated metastatic function in gastric cancer. We found that stimulation of BMP-2 in gastric cancer cells enhanced the phosphorylation of AKT and ERK. Accompanying activation of AKT and ERK kinase, BMP-2 also enhanced phosphorylation/degradation of I{kappa}B{alpha} and the nuclear translocation/activation of NF-{kappa}B. Interestingly, blockade of PI3K/AKT and ERK signaling using LY294002 and PD98059, respectively, significantly inhibited BMP-2-induced motility and invasiveness in association with the activation of NF-{kappa}B. Furthermore, BMP-2-induced MMP-9 expression and enzymatic activity was also significantly blocked by treatment with PI3K/AKT, ERK, or NF-{kappa}B inhibitors. Immunohistochemistry staining of 178 gastric tumor biopsies indicated that expression of BMP-2 and MMP-9 had a significant positive correlation with lymph node metastasis and a poor prognosis. These results indicate that the BMP-2 signaling pathway enhances tumor metastasis in gastric cancer by sequential activation of the PI3K/AKT or MAPK pathway followed by the induction of NF-{kappa}B and MMP-9 activity, indicating that BMP-2 has the potential to be a therapeutic molecular target to decrease metastasis.

  20. Architecture and Bloch-Maxwell modelling of multi-mJ 100 fs fully-coherent soft X-ray laser based on X-ray CPA

    SciTech Connect (OSTI)

    Zeitoun, Ph.; Oliva, E.; Fajardo, M.; Cheriaux, G.; Le, T. T. T.; Li, L.; Pitman, M.; Ros, D.; Sebban, S.; Velarde, P. [Laboratoire d'Optique Appliquee, ENSTA-PariesTech, CNRS, Ecole Poluytehcnique-PariesTech, chemin d ela huniere, Palaiseau (France); Laboratoire d'Optique Appliquee, ENSTA-PariesTech, CNRS, Ecole Poluytehcnique-PariesTech, chemin d ela huniere, Palaiseau (France); GoLP, Instituto de Plasmas e Fusao Nuclear, Laboratorio Associado, Instituto Superior Tecnico, Lisbon (Portugal); Laboratoire d'Optique Appliquee, ENSTA-PariesTech, CNRS, Ecole Poluytehcnique-PariesTech, chemin d ela huniere, Palaiseau (France); CLUPS, EA4127, Bat 106, Universite Paris-Sud, 91405 Orsay (France); Laboratoire d'Optique Appliquee, ENSTA-PariesTech, CNRS, Ecole Poluytehcnique-PariesTech, chemin d ela huniere, Palaiseau (France); Instituto de Fusion Nuclear, Universidad Politecnica de Madrid, Madrid (Spain)

    2012-07-09T23:59:59.000Z

    By seeding amplifying plasmas pumped with the so-called Transient collisionnal excitation scheme, the amplified pulse seems to be limited to an energy of several 10's of {mu}J. Aiming to attain several mJ, we study the seeding of plasma pumped by long laser pulse. Thanks to our time-dependent Maxwell-Bloch code, we demonstrate that direct seeding with femtosecond pulse is inefficient. We also study the amplification of pulse train with the drawback of re-synchronizing the pulses. We proposed and studied the amplification of high harmonic seed stretched by a grating pair, amplified finally compressed. We consider off-axis diffraction on the gratings for maximizing their efficiency. Considering the phase deformation induced by the amplification and the spectral narrowing the final pulse is 230 fs in duration and 5 mJ.

  1. PROPERTIES OF Cd and Zn PARTIAL ELECTROLYTE TREATED CIGS SOLAR CELLS K. Ramanathan, F.S. Hasoon, S. Smith, A. Mascarenhas, H. Al-Thani, J. Alleman, H.S. Ullal and J. Keane

    E-Print Network [OSTI]

    Sites, James R.

    PROPERTIES OF Cd and Zn PARTIAL ELECTROLYTE TREATED CIGS SOLAR CELLS K. Ramanathan, F.S. Hasoon, SS/CIGS interface has been treated as a "non- interacting," or abrupt junction. There are a few reports [3 changes such as those mentioned above have not been adequately treated in further analysis of the junction

  2. Inhibition of inflammatory mediators contributes to the anti-inflammatory activity of KYKZL-1 via MAPK and NF-?B pathway

    SciTech Connect (OSTI)

    Xu, Guang-Lin [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Department of Pharmacology, University of Michigan, Ann Arbor (United States); Du, Yi-Fang; Cheng, Jing; Huan, Lin [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Chen, Shi-Cui [Jinhu Food and Drug Administration, Jiangsu (China); Wei, Shao-Hua [College of Chemistry and Materials Science, Nanjing Normal University, Nanjing (China); Gong, Zhu-Nan, E-mail: biopharmacology@126.com [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Cai, Jie; Qiu, Ting; Wu, Hao; Sun, Ting [Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing (China); Ao, Gui-Zhen [Department of Medicinal Chemistry, School of Pharmacy, Soochow University, Jiangsu (China)

    2013-10-01T23:59:59.000Z

    KYKZL-1, a newly synthesized compound with COX/5-LOX dual inhibition, was subjected to the anti-inflammatory activity test focusing on its modulation of inflammatory mediators as well as intracellular MAPK and NF-?B signaling pathways. In acute ear edema model, pretreatment with KYKZL-1 (p.o.) dose-dependently inhibited the xylene-induced ear edema in mice with a higher inhibition than diclofenac. In a three-day TPA-induced inflammation, KYKZL-1 also showed significant anti-inflammatory activity with inhibition ranging between 20% and 64%. In gastric lesion test, KYKZL-1 elicited markedly fewer stomach lesions with a low index of ulcer as compared to diclofenac in rats. In further studies, KYKZL-1 was found to significantly inhibit the production of NO, PGE{sub 2}, LTB{sub 4} in LPS challenged RAW264.7, which is parallel to its attenuation of the expression of iNOS, COX-2, 5-LOX mRNAs or proteins and inhibition of phosphorylation of p38 and ERK MAPKs and activation of NF-?B. Taken together, our data indicate that KYKZL-1 comprises dual inhibition of COX and 5-LOX and exerts an obvious anti-inflammatory activity with an enhanced gastric safety profile via simultaneous inhibition of phosphorylation of p38 and ERK MAPKs and activation of NF-?B. - Highlights: • KYKZL-1 is designed to exhibit COX/5-LOX dual inhibition. • KYKZL-1 inhibits NO, PGE{sub 2} and LTB{sub 4} and iNOS, COX-2 and 5-LOX mRNAs and MAPKs. • KYKZL-1 inhibits phosphorylation of MAPKs. • KYKZL-1 inactivates NF-?B pathway.

  3. Carbachol ameliorates lipopolysaccharide-induced intestinal epithelial tight junction damage by down-regulating NF-{kappa}{beta} and myosin light-chain kinase pathways

    SciTech Connect (OSTI)

    Zhang, Ying [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China)] [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China); Li, Jianguo, E-mail: 2010lijianguo@sina.cn [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China)] [Department of Anesthesia, Critical Care Medicine and Emergency Medicine Center, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, People's Republic of China (China)

    2012-11-16T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Carbachol reduced the lipopolysaccharide-induced intestinal barrier breakdown. Black-Right-Pointing-Pointer Carbachol ameliorated the lipopolysaccharide-induced ileal tight junction damage. Black-Right-Pointing-Pointer Carbachol prevented the LPS-induced NF-{kappa}{beta} and myosin light-chain kinase activation. Black-Right-Pointing-Pointer Carbachol exerted its beneficial effects in an {alpha}7 nicotinic receptor-dependent manner. -- Abstract: Carbachol is a cholinergic agonist that protects the intestines after trauma or burn injury. The present study determines the beneficial effects of carbachol and the mechanisms by which it ameliorates the lipopolysaccharide (LPS)-induced intestinal barrier breakdown. Rats were injected intraperitoneally with 10 mg/kg LPS. Results showed that the gut barrier permeability was reduced, the ultrastructural disruption of tight junctions (TJs) was prevented, the redistribution of zonula occludens-1 and claudin-2 proteins was partially reversed, and the nuclear factor-kappa beta (NF-{kappa}{beta}) and myosin light-chain kinase (MLCK) activation in the intestinal epithelium were suppressed after carbachol administration in LPS-exposed rats. Pretreatment with the {alpha}7 nicotinic acetylcholine receptor ({alpha}7nAchR) antagonist {alpha}-bungarotoxin blocked the protective action of carbachol. These results suggested that carbachol treatment can protect LPS-induced intestinal barrier dysfunction. Carbachol exerts its beneficial effect on the amelioration of the TJ damage by inhibiting the NF-{kappa}{beta} and MLCK pathways in an {alpha}7nAchR-dependent manner.

  4. Broken Valence Chiral Symmetry and Chiral Polarization of Dirac Spectrum in N$_f$=12 QCD at Small Quark Mass

    E-Print Network [OSTI]

    Andrei Alexandru; Ivan Horváth

    2014-12-04T23:59:59.000Z

    The validity of recently proposed equivalence between valence spontaneous chiral symmetry breaking (vSChSB) and chiral polarization of low energy Dirac spectrum (ChP) in SU(3) gauge theory, is examined for the case of twelve mass-degenerate fundamental quark flavors. We find that the vSChSB-ChP correspondence holds for regularized systems studied. Moreover, our results suggest that vSChSB occurs in two qualitatively different circumstances: there is a quark mass $m_c$ such that for $m > m_c$ the mode condensing Dirac spectrum exhibits standard monotonically increasing density, while for $m_{ch} < m < m_c$ the peak around zero separates from the bulk of the spectrum, with density showing a pronounced depletion at intermediate scales. Valence chiral symmetry restoration may occur at yet smaller masses $m < m_{ch}$, but this has not yet been seen by overlap valence probe, leaving the $m_{ch}=0$ possibility open. The latter option could place massless N$_f$=12 theory outside of conformal window. Anomalous behavior of overlap Dirac spectrum for $m_{ch} < m < m_c$ is qualitatively similar to one observed previously in zero and few-flavor theories as an effect of thermal agitation.

  5. Up, down, strange and charm quark masses with Nf = 2+1+1 twisted mass lattice QCD

    E-Print Network [OSTI]

    N. Carrasco; A. Deuzeman; P. Dimopoulos; R. Frezzotti; V. Gimenez; G. Herdoiza; P. Lami; V. Lubicz; D. Palao; E. Picca; S. Recker; L. Riggio; G. C. Rossi; F. Sanfilippo; L. Scorzato; S. Simula; C. Tarantino; C. Urbach; U. Wenger

    2014-08-21T23:59:59.000Z

    We present a lattice QCD calculation of the up, down, strange and charm quark masses performed using the gauge configurations produced by the European Twisted Mass Collaboration with Nf = 2 + 1 + 1 dynamical quarks, which include in the sea, besides two light mass degenerate quarks, also the strange and charm quarks with masses close to their physical values. The simulations are based on a unitary setup for the two light quarks and on a mixed action approach for the strange and charm quarks. The analysis uses data at three values of the lattice spacing and pion masses in the range 210 - 450 MeV, allowing for accurate continuum limit and controlled chiral extrapolation. The quark mass renormalization is carried out non-perturbatively using the RI-MOM method. The results for the quark masses converted to the bar{MS} scheme are: mud(2 GeV) = 3.70(17) MeV, ms(2 GeV) = 99.6(4.3) MeV and mc(mc) = 1.348(46) GeV. We obtain also the quark mass ratios ms/mud = 26.66(32) and mc/ms = 11.62(16). By studying the mass splitting between the neutral and charged kaons and using available lattice results for the electromagnetic contributions, we evaluate mu/md = 0.470(56), leading to mu = 2.36(24) MeV and md = 5.03(26) MeV.

  6. Rosiglitazone attenuates NF-{kappa}B-dependent ICAM-1 and TNF-{alpha} production caused by homocysteine via inhibiting ERK{sub 1/2}/p38MAPK activation

    SciTech Connect (OSTI)

    Bai, Yong-Ping [Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China); Liu, Yu-Hui [Department of Pharmacology, College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330006 (China); Chen, Jia [Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China); Song, Tao [Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078 (China); You, Yu [Department of Digestive Medicine, Xiangya Second Hospital, Central South University, Changsha, Hunan 410078 (China); Tang, Zhen-Yan [Department of Urologic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China); Li, Yuan-Jian [Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078 (China); Zhang, Guo-Gang [Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410078 (China)]. E-mail: xyzgg2006@sina.com

    2007-08-17T23:59:59.000Z

    Previous studies demonstrated an important interaction between nuclear factor-kappaB (NF-{kappa}B) activation and homocysteine (Hcy)-induced cytokines expression in endothelial cells and vascular smooth muscle cells. However, the underlying mechanism remains illusive. In this study, we investigated the effects of Hcy on NF-{kappa}B-mediated sICAM-1, TNF-{alpha} production and the possible involvement of ERK{sub 1/2}/p38MAPK pathway. The effects of rosiglitazone intervention were also examined. Our results show that Hcy increased the levels of sICAM-1 and TNF-{alpha} in cultured human umbilical vein endothelial cells (HUVECs) in a time- and concentration-dependent manner. This effect was significantly depressed by rosiglitazone and different inhibitors (PDTC, NF-{kappa}B inhibitor; PD98059, MEK inhibitor; SB203580, p38MAPK specific inhibitor; and staurosporine, PKC inhibitor). Next, we investigated the effect of Hcy on ERK{sub 1/2}/p38MAPK pathway and NF-{kappa}B activity in HUVECs. The results show that Hcy activated both ERK{sub 1/2}/p38MAPK pathway and NF-{kappa}B-DNA-binding activity. These effects were markedly inhibited by rosiglitazone as well as other inhibitors (SB203580, PD98059, and PDTC). Further, the pretreatment of staurosporine abrogated ERK{sub 1/2}/p38MAPK phosphorylation, suggesting that Hcy-induced ERK{sub 1/2}/p38MAPK activation is associated with PKC activity. Our results provide evidence that Hcy-induced NF-{kappa}B activation was mediated by activation of ERK{sub 1/2}/p38MAPK pathway involving PKC activity. Rosiglitazone reduces the NF-{kappa}B-mediated sICAM-1 and TNF-{alpha} production induced by Hcy via inhibition of ERK{sub 1/2}/p38MAPK pa0011thw.

  7. Design and Performance Characteristics of the ORNL AdvancedMicroscopy Laboratory and JEOL 2200FS-AC Aberration-CorrectedSTEM/TEM

    SciTech Connect (OSTI)

    Allard, Lawrence F.; Blom, Douglas A.; O'Keefe, Michael A.; Mishina, S.

    2005-02-15T23:59:59.000Z

    At ORNL, the new Advanced Microscopy Laboratory (AML) has recently been completed, with two aberration-corrected instruments installed, and two more planned in the near future to fill the 4-laboratory building. The installed JEOL 2200FS-AC has demonstrated aTEM information limit of 0.9A. This limit is expected given the measured instrument parameters (HT and OL power supply stabilities, beam energy spread, etc.), and illustrates that the environmental influences are not adversely affecting the instrument performance. In STEM high-angle annular dark-field (HA-ADF) mode, images of a thin Si crystal in<110>zone axis orientation, after primary aberrations in the illuminating beam were optimally corrected, showed a significant vibration effect. The microscope is fitted with three magnetically levitated turbo pumps (one on the column at about the specimen position,and two near floor level) that pump the Omega energy filter and detector chamber. These pumps run at 48,000 rpm, precisely equivalent to 800Hz. It was determined that the upper turbo pump was contributing essentially all of the 800Hz signal to the image, and in fact that the pump was defective. After replacing the pump with one significantly quieter than the original, the Si atomic column image and associated diffractogram(Fig. 4b) show a much-reduced effect of the 800Hz signal, but still some residual effect from the turbo pump. The upper pump will be removed from the main column to an adjacent frame on the floor, and will have a large-diameter, well-damped, pump line to the original connection to the column to effectively isolate the pump from the column. If the 800Hz signal results from mechanical vibrations, they will be damped, and if the signal results from acoustic coupling to the column, it can be damped by appropriate acoustic materials.

  8. Anti-neuroinflammatory efficacy of the aldose reductase inhibitor FMHM via phospholipase C/protein kinase C-dependent NF-?B and MAPK pathways

    SciTech Connect (OSTI)

    Zeng, Ke-Wu [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191 (China); Li, Jun [Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029 (China); Dong, Xin; Wang, Ying-Hong; Ma, Zhi-Zhong; Jiang, Yong; Jin, Hong-Wei [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191 (China); Tu, Peng-Fei, E-mail: pengfeitu@vip.163.com [State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191 (China); Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029 (China)

    2013-11-15T23:59:59.000Z

    Aldose reductase (AR) has a key role in several inflammatory diseases: diabetes, cancer and cardiovascular diseases. Therefore, AR inhibition seems to be a useful strategy for anti-inflammation therapy. In the central nervous system (CNS), microglial over-activation is considered to be a central event in neuroinflammation. However, the effects of AR inhibition in CNS inflammation and its underlying mechanism of action remain unknown. In the present study, we found that FMHM (a naturally derived AR inhibitor from the roots of Polygala tricornis Gagnep.) showed potent anti-neuroinflammatory effects in vivo and in vitro by inhibiting microglial activation and expression of inflammatory mediators. Mechanistic studies showed that FMHM suppressed the activity of AR-dependent phospholipase C/protein kinase C signaling, which further resulted in downstream inactivation of the I?B kinase/I?B/nuclear factor-kappa B (NF-?B) inflammatory pathway. Therefore, AR inhibition-dependent NF-?B inactivation negatively regulated the transcription and expression of various inflammatory genes. AR inhibition by FMHM exerted neuroprotective effects in lipopolysaccharide-induced neuron–microglia co-cultures. These findings suggested that AR is a potential target for neuroinflammation inhibition and that FMHM could be an effective agent for treating or preventing neuroinflammatory diseases. - Highlights: • FMHM is a natural-derived aldose reductase (AR) inhibitor. • FMHM inhibits various neuroinflammatory mediator productions in vitro and in vivo. • FMHM inhibits neuroinflammation via aldose reductase/PLC/PKC-dependent NF-?B pathway. • FMHM inhibits neuroinflammation via aldose reductase/PLC/PKC-dependent MAPK pathway. • FMHM protects neurons against inflammatory injury in microglia-neuron co-cultures.

  9. Impaired NFAT and NF?B activation are involved in suppression of CD40 ligand expression by ?{sup 9}-tetrahydrocannabinol in human CD4{sup +} T cells

    SciTech Connect (OSTI)

    Ngaotepprutaram, Thitirat [Department of Pharmacology and Toxicology, Michigan State University (United States); Center for Integrative Toxicology, Michigan State University (United States); Kaplan, Barbara L.F. [Department of Pharmacology and Toxicology, Michigan State University (United States); Center for Integrative Toxicology, Michigan State University (United States); Neuroscience Program, Michigan State University (United States); Kaminski, Norbert E., E-mail: kamins11@msu.edu [Department of Pharmacology and Toxicology, Michigan State University (United States); Center for Integrative Toxicology, Michigan State University (United States)

    2013-11-15T23:59:59.000Z

    We have previously reported that ?{sup 9}-tetrahydrocannabinol (?{sup 9}-THC), the main psychoactive cannabinoid in marijuana, suppresses CD40 ligand (CD40L) expression by activated mouse CD4{sup +} T cells. CD40L is involved in pathogenesis of many autoimmune and inflammatory diseases. In the present study, we investigated the molecular mechanism of ?{sup 9}-THC-mediated suppression of CD40L expression using peripheral blood human T cells. Pretreatment with ?{sup 9}-THC attenuated CD40L expression in human CD4{sup +} T cells activated by anti-CD3/CD28 at both the protein and mRNA level, as determined by flow cytometry and quantitative real-time PCR, respectively. Electrophoretic mobility shift assays revealed that ?{sup 9}-THC suppressed the DNA-binding activity of both NFAT and NF?B to their respective response elements within the CD40L promoter. An assessment of the effect of ?{sup 9}-THC on proximal T cell-receptor (TCR) signaling induced by anti-CD3/CD28 showed significant impairment in the rise of intracellular calcium, but no significant effect on the phosphorylation of ZAP70, PLC?1/2, Akt, and GSK3?. Collectively, these findings identify perturbation of the calcium-NFAT and NF?B signaling cascade as a key mechanistic event by which ?{sup 9}-THC suppresses human T cell function. - Highlights: • ?{sup 9}-THC attenuated CD40L expression in activated human CD4+ T cells. • ?{sup 9}-THC suppressed DNA-binding activity of NFAT and NF?B. • ?{sup 9}-THC impaired elevation of intracellular Ca2+. • ?{sup 9}-THC did not affect phosphorylation of ZAP70, PLC?1/2, Akt, and GSK3?.

  10. The NSVZ beta-function and the Schwinger-Dyson equations for N=1 SQED with N_f flavors, regularized by higher derivatives

    E-Print Network [OSTI]

    K. V. Stepanyantz

    2014-06-08T23:59:59.000Z

    The effective diagram technique based on the Schwinger-Dyson equations is constructed for N=1 SQED with N_f flavors, regularized by higher derivatives. Using these effective diagrams, it is possible to derive the exact NSVZ relation between the beta-function and the anomalous dimension of the matter superfields exactly in all loops, if the renormalization group functions are defined in terms of the bare coupling constant. In particular, we verify that all integrals which give the beta-function defined in terms of the bare coupling constant are integrals of double total derivatives and prove some identities relating Green functions.

  11. OSU-A9 inhibits angiogenesis in human umbilical vein endothelial cells via disrupting Akt–NF-?B and MAPK signaling pathways

    SciTech Connect (OSTI)

    Omar, Hany A. [Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210 (United States); Department of Pharmacology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514 (Egypt); Arafa, El-Shaimaa A. [Department of Pharmacology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514 (Egypt); Salama, Samir A. [Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11511 (Egypt); Arab, Hany H. [Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo 11562 (Egypt); Wu, Chieh-Hsi, E-mail: chhswu@mail.cmu.edu.tw [School of Pharmacy, China Medical University, Taichung 40402, Taiwan (China); Weng, Jing-Ru, E-mail: columnster@gmail.com [Department of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan (China)

    2013-11-01T23:59:59.000Z

    Since the introduction of angiogenesis as a useful target for cancer therapy, few agents have been approved for clinical use due to the rapid development of resistance. This problem can be minimized by simultaneous targeting of multiple angiogenesis signaling pathways, a potential strategy in cancer management known as polypharmacology. The current study aimed at exploring the anti-angiogenic activity of OSU-A9, an indole-3-carbinol-derived pleotropic agent that targets mainly Akt–nuclear factor-kappa B (NF-?B) signaling which regulates many key players of angiogenesis such as vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). Human umbilical vein endothelial cells (HUVECs) were used to study the in vitro anti-angiogenic effect of OSU-A9 on several key steps of angiogenesis. Results showed that OSU-A9 effectively inhibited cell proliferation and induced apoptosis and cell cycle arrest in HUVECs. Besides, OSU-A9 inhibited angiogenesis as evidenced by abrogation of migration/invasion and Matrigel tube formation in HUVECs and attenuation of the in vivo neovascularization in the chicken chorioallantoic membrane assay. Mechanistically, Western blot, RT-PCR and ELISA analyses showed the ability of OSU-A9 to inhibit MMP-2 production and VEGF expression induced by hypoxia or phorbol-12-myristyl-13-acetate. Furthermore, dual inhibition of Akt–NF-?B and mitogen-activated protein kinase (MAPK) signaling, the key regulators of angiogenesis, was observed. Together, the current study highlights evidences for the promising anti-angiogenic activity of OSU-A9, at least in part through the inhibition of Akt–NF-?B and MAPK signaling and their consequent inhibition of VEGF and MMP-2. These findings support OSU-A9's clinical promise as a component of anticancer therapy. - Highlights: • The antiangiogenic activity of OSU-A9 in HUVECs was explored. • OSU-A9 inhibited HUVECs proliferation, migration, invasion and tube formation. • OSU-A9 targeted signaling pathways mediated by Akt-NF-kB, VEGF, and MMP-2. • The anti-angiogenic activity of OSU-A9 supports its clinical promise.

  12. Overview FS old.pdf

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011 Strategic2 OPAM615_CostNSAR - T en Y earEnergy T HK-12OtherOverseas Corps Training

  13. NF_Eder_2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Saleshttp://www.fnal.gov/directorate/nalcal/nalcal02_07_05_files/nalcal.gif Directorate1, Issue 23 NETL NEVIS- 97NEWS RELEASE For3

  14. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-{kappa}B activation and the JAK/STAT pathway

    SciTech Connect (OSTI)

    Lv, Na; Kim, Eun-Kyung; Song, Mi-Young [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of); Choi, Ha-Na; Moon, Woo Sung [Department of Pathology, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Pathology, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of); Park, Sung-Joo [Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749 (Korea, Republic of)] [Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749 (Korea, Republic of); Park, Jin-Woo [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of); Kwon, Kang-Beom, E-mail: desson@wonkwang.ac.kr [Department of Physiology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749 (Korea, Republic of)] [Department of Physiology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 570-749 (Korea, Republic of); Park, Byung-Hyun, E-mail: bhpark@chonbuk.ac.kr [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)] [Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756 (Korea, Republic of)

    2009-07-15T23:59:59.000Z

    JANEX-1/WHI-P131, a selective Janus kinase 3 (JAK3) inhibitor, has been shown to delay the onset of diabetes in the NOD mouse model. However, the molecular mechanism by which JANEX-1 protects pancreatic {beta}-cells is unknown. In the current study, we investigated the role of JANEX-1 on interleukin (IL)-1{beta} and interferon (IFN)-{gamma}-induced {beta}-cell damage using isolated islets. JANEX-1-pretreated islets showed resistance to cytokine toxicity, namely suppressed nitric oxide (NO) production, reduced inducible form of NO synthase (iNOS) expression, and decreased islet destruction. The molecular mechanism by which JANEX-1 inhibits iNOS expression was mediated through suppression of the nuclear factor {kappa}B (NF-{kappa}B) and JAK/signal transducer and activator of transcription (STAT) pathways. Islets treated with the cytokines downregulated the protein levels of suppressor of cytokine signaling (SOCS)-1 and SOCS-3, but pretreatment with JANEX-1 attenuated these decreases. Additionally, islets from JAK3{sup -/-} mice were more resistant to cytokine toxicity than islets from control mice. These results demonstrate that JANEX-1 protects {beta}-cells from cytokine toxicity through suppression of the NF-{kappa}B and JAK/STAT pathways and upregulation of SOCS proteins, suggesting that JANEX-1 may be used to preserve functional {beta}-cell mass.

  15. Early induction of cytokines/cytokine receptors and Cox2, and activation of NF-?B in 4-nitroquinoline 1-oxide-induced murine oral cancer model

    SciTech Connect (OSTI)

    Liu, Yu-Ching [Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan (China) [Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan (China); Department of Veterinary Medicine, National Chung Hsing University, Taichung 402, Taiwan (China); Ho, Heng-Chien; Lee, Miau-Rong [Department of Biochemistry, China Medical University, Taichung 404, Taiwan (China)] [Department of Biochemistry, China Medical University, Taichung 404, Taiwan (China); Lai, Kuang-Chi [Department of Surgery, China Medical University Beigang Hospital, Yunlin 651, Taiwan (China) [Department of Surgery, China Medical University Beigang Hospital, Yunlin 651, Taiwan (China); School of Medicine, China Medical University, Taichung 404, Taiwan (China); Yeh, Chung-Min; Lin, Yueh-Min [Department of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan (China)] [Department of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan (China); Ho, Tin-Yun [School of Chinese Medicine, China Medical University, Taichung 404, Taiwan (China)] [School of Chinese Medicine, China Medical University, Taichung 404, Taiwan (China); Hsiang, Chien-Yun, E-mail: cyhsiang@mail.cmu.edu.tw [Department of Microbiology, China Medical University, Taichung 404, Taiwan (China)] [Department of Microbiology, China Medical University, Taichung 404, Taiwan (China); Chung, Jing-Gung, E-mail: jgchung@mail.cmu.edu.tw [Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan (China) [Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan (China); Department of Biotechnology, Asia University, Taichung 413, Taiwan (China)

    2012-07-15T23:59:59.000Z

    The purpose of this study was to identify the genes induced early in murine oral carcinogenesis. Murine tongue tumors induced by the carcinogen, 4-nitroquinoline 1-oxide (4-NQO), and paired non-tumor tissues were subjected to microarray analysis. Hierarchical clustering of upregulated genes in the tumor tissues revealed an association of induced genes with inflammation. Cytokines/cytokine receptors induced early were subsequently identified, clearly indicating their involvement in oral carcinogenesis. Hierarchical clustering also showed that cytokine-mediated inflammation was possibly linked with Mapk6. Cox2 exhibited the greatest extent (9–18 fold) of induction in the microarray data, and its early induction was observed in a 2 h painting experiment by RT-PCR. MetaCore analysis showed that overexpressed Cox2 may interact with p53 and transcriptionally inhibit expression of several downstream genes. A painting experiment in transgenic mice also demonstrated that NF-?B activates early independently of Cox2 induction. MetaCore analysis revealed the most striking metabolic alterations in tumor tissues, especially in lipid metabolism resulting from the reduction of Ppar? and Rxrg. Reduced expression of Mapk12 was noted, and MetaCore analysis established its relationship with decreased efficiency of Ppar? phosphorylation. In conclusion, in addition to cytokines/cytokine receptors, the early induction of Cox2 and NF-?B activation is involved in murine oral carcinogenesis.

  16. High-loop perturbative renormalization constants for Lattice QCD (III): three-loop quark currents for Iwasaki gauge action and n_f=4 Wilson fermions

    E-Print Network [OSTI]

    M. Brambilla; F. Di Renzo; M. Hasegawa

    2014-06-23T23:59:59.000Z

    This is the third of a series of papers on three-loop computation of renormalization constants for Lattice QCD. Our main point of interest are results for the regularization defined by Iwasaki gauge action and n_f=4 Wilson fermions. Our results for quark bilinears renormalized according to the RI'-MOM scheme can be compared to non-perturbative results. The latter are available for Twisted Mass QCD: being defined in the chiral limit, renormalization constants must be the same. We also address more general problems. In particular, we discuss a few methodological issues connected to summing the perturbative series such as the effectiveness of Boosted Perturbation Theory and the disentanglement of irrelevant and finite volume contributions. Discussing these issues we consider ont only the new results of this paper, but also those for the regularization defined by tree-level Symanzik improved gauge action and n_f=2 Wilson fermions, which we presented in a recent paper of ours. We finally comment to which extent the techniques we put at work in the NSPT context can provide a fresher look into the lattice version of the RI'-MOM scheme.

  17. A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-?B and Nrf2-Keap1 signaling pathways

    SciTech Connect (OSTI)

    Gan, Fei-Fei; Ling, Hui; Ang, Xiaohui; Reddy, Shridhivya A.; Lee, Stephanie S-H.; Yang, Hong; Tan, Sock-Hoon [Department of Pharmacy, Faculty of Science, National University of Singapore (Singapore); Hayes, John D. [Jacqui Wood Cancer Centre, Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland (United Kingdom); Chui, Wai-Keung [Department of Pharmacy, Faculty of Science, National University of Singapore (Singapore); Chew, Eng-Hui, E-mail: phaceh@nus.edu.sg [Department of Pharmacy, Faculty of Science, National University of Singapore (Singapore)

    2013-11-01T23:59:59.000Z

    Natural compounds containing vanilloid and Michael acceptor moieties appear to possess anti-cancer and chemopreventive properties. The ginger constituent shogaol represents one such compound. In this study, the anti-cancer potential of a synthetic novel shogaol analog 3-phenyl-3-shogaol (3-Ph-3-SG) was assessed by evaluating its effects on signaling pathways. At non-toxic concentrations, 3-Ph-3-SG suppressed cancer cell invasion in MDA-MB-231 and MCF-7 breast carcinoma cells through inhibition of PMA-activated MMP-9 expression. At similar concentrations, 3-Ph-3-SG reduced expression of the inflammatory mediators nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and prostanglandin-E{sub 2} (PGE{sub 2}) in RAW 264.7 macrophage-like cells. Inhibition of cancer cell invasion and inflammation by 3-Ph-3-SG were mediated through suppression of the nuclear factor-kappaB (NF-?B) signaling pathway. The 3-Ph-3-SG also demonstrated cytoprotective effects by inducing the antioxidant response element (ARE)-driven genes NAD(P)H quinone oxidoreductase-1 (NQO1) and heme oxygenase-1 (HO-1). Cytoprotection by 3-Ph-3-SG was achieved at least partly through modification of cysteine residues in the E3 ubiquitin ligase substrate adaptor Kelch-like ECH-associated protein 1 (Keap1), which resulted in accumulation of transcription factor NF-E2 p45-related factor 2 (Nrf2). The activities of 3-Ph-3-SG were comparable to those of 6-shogaol, the most abundant naturally-occurring shogaol, and stronger than those of 4-hydroxyl-null deshydroxy-3-phenyl-3-shogaol, which attested the importance of the 4-hydroxy substituent in the vanilloid moiety for bioactivity. In summary, 3-Ph-3-SG is shown to possess activities that modulate stress-associated pathways relevant to multiple steps in carcinogenesis. Therefore, it warrants further investigation of this compound as a promising candidate for use in chemotherapeutic and chemopreventive strategies. - Highlights: • Novel shogaol 3-phenyl-3-shogaol suppressed cancer cell invasion and inflammation. • Anti-invasive and anti-inflammatory effects were NF-?B-dependent. • 3-Phenyl-3-shogaol induced ARE-driven genes to achieve cytoprotection. • Cytoprotective effects were brought about by modification of cysteines in Keap1. • Chemopreventive activities of 3-phenyl-3-shogaol and 6-shogaol were comparable.

  18. Microtrenching-free two-step reactive ion etching of 4H-SiC using NF{sub 3}/HBr/O{sub 2} and Cl{sub 2}/O{sub 2}

    SciTech Connect (OSTI)

    Tseng, Yuan-Hung, E-mail: yhtseng.ee99g@nctu.edu.tw; Tsui, Bing-Yue [Department of Electronics Engineering, National Chiao Tung University, No. 1001, Daxue Rd., East Dist., Hsinchu City 30010, Taiwan (China)

    2014-05-15T23:59:59.000Z

    In this paper, the authors performed a reactive ion etch of a 4H-SiC substrate with a gas mixture of NF{sub 3}, HBr, and O{sub 2}, resulting in a microtrenching-free etch. The etch rate was 107.8?nm/min, and the selectivity over the oxide hard mask was ?3.85. Cross-sectional scanning electron microscopy showed no microtrenching compared with etches using plasmas of NF{sub 3}, NF{sub 3}/HBr, and NF{sub 3}/O{sub 2}. Analyzing a variety of HBr/O{sub 2} mixing ratios, the authors discuss the additive effect of each gas and their respective potential mechanisms for alleviating microtrenching. To increase the radius of gyration of the bottom corners, they introduced a second etch step with Cl{sub 2}/O{sub 2} plasma. Fabricating simple metal-oxide-semiconductor capacitors on the two-step etched surface, the authors found that the electrical characteristics of the etched sample were nearly the same as the nonetched sample.

  19. Relation between two-point Green functions of ${\\cal N}=1$ SQED with $N_f$ flavors, regularized by higher derivatives, in the three-loop approximation

    E-Print Network [OSTI]

    A. E. Kazantsev; K. V. Stepanyantz

    2014-10-05T23:59:59.000Z

    We verify the identity which relates the two-point Green functions of ${\\cal N}=1$ SQED with $N_f$ flavors, regularized by higher derivatives, by explicit calculations in the three-loop approximation. This identity explains why in the limit of the vanishing external momentum the two-point Green function of the gauge superfield is given by integrals of double total derivatives in the momentum space. It also allows to derive the NSVZ $\\beta$-function exactly in all loops if the renormalization group functions are defined in terms of the bare coupling constant. In order to verify the considered identity we use it for constructing integrals giving the three-loop $\\beta$-function starting from the two-point Green functions of the matter superfields in the two-loop approximation. Then we demonstrate that the results for these integrals coincide with the sums of the corresponding three-loop supergraphs.

  20. 4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-{kappa}B and ERK/MAPK

    SciTech Connect (OSTI)

    Chen Zhihua [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Na, Hye-Kyung [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Hurh, Yeon-Jin [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Surh, Young-Joon [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of)]. E-mail: surh@plaza.snu.ac.kr

    2005-10-01T23:59:59.000Z

    Catechol estrogens, the hydroxylated metabolites of 17{beta}-estradiol (E{sub 2}), have been considered to be implicated in estrogen-induced carcinogenesis. 4-Hydroxyestradiol (4-OHE{sub 2}), an oxidized metabolite of E{sub 2} formed preferentially by cytochrome P450 1B1, reacts with DNA to form depurinating adducts thereby exerting genotoxicity and carcinogenicity. 4-OHE{sub 2} undergoes 2-electron oxidation to quinone via semiquinone, and during this process, reactive oxygen species (ROS) can be generated to cause DNA damage and cell death. In the present study, 4-OHE{sub 2} was found to elicit cytotoxicity in cultured human mammary epithelial (MCF-10A) cells, which was blocked by the antioxidant trolox. MCF-10A cells treated with 4-OHE{sub 2} exhibited increased intracellular ROS accumulation and 8-oxo-7,8-dihydroxy-2'-deoxyguanosine formation, and underwent apoptosis as determined by poly(ADP-ribose)polymerase cleavage and disruption of mitochondrial transmembrane potential. The redox-sensitive transcription factor nuclear factor {kappa}B (NF-{kappa}B) was transiently activated by 4-OHE{sub 2} treatment. Cotreatment of MCF-10A cells with the NF-{kappa}B inhibitor, L-1-tosylamido-2-phenylethyl chloromethyl ketone, exacerbated 4-OHE{sub 2}-induced cell death. 4-OHE{sub 2} also caused transient activation of extracellular signal-regulated protein kinases (ERK) involved in transmitting cell survival or death signals. A pharmacological inhibitor of ERK aggravated the 4-OHE{sub 2}-induced cytotoxicity, supporting the pivotal role of ERK in protecting against catechol estrogen-induced oxidative cell death.

  1. Nature of Roberge-Weiss transition end points for heavy quarks in $N_f=2$ lattice QCD with Wilson fermions

    E-Print Network [OSTI]

    Liang-Kai Wu; Xiang-Fei Meng

    2014-10-26T23:59:59.000Z

    The phase structure of QCD with imaginary chemical potential provides information on the phase diagram of QCD with real chemical potential. With imaginary chemical potential $i\\mu_I=i\\pi T$, previous studies show that the Roberge-Weiss (RW) transition end points are triple points at both large and small quark masses, and second order transition points at intermediate quark masses. The triple and second order end points are separated by two tricritical ones. We present simulations with $ N_f=2 $ Wilson fermions to investigate the nature of RW transition end points. The simulations are carried out at 8 values of the hopping parameter $\\kappa$ ranging from 0.020 to 0.140 on different lattice volumes. The Binder cumulant, susceptibility and reweighted distribution of the imaginary part of Polyakov loop are employed to determine the nature of RW transition end points. The simulations show that the two tricritical points are within the range $0.070-0.080$ and $0.120-0.140$, respectively.

  2. Measurement of the F2n/F2p and d/u Ratios in Deep Inelastic Electron Scattering off 3H and 3He

    E-Print Network [OSTI]

    G. G. Petratos; I. R. Afnan; F. Bissey; J. Gomez; A. T. Katramatou; W. Melnitchouk; A. W. Thomas

    2000-10-19T23:59:59.000Z

    We discuss a possible measurement of the ratio of the nucleon structure functions, F2n/F2p, and the ratio of the up to down quark distributions, u/d, at large x, by performing deep inelastic electron scattering from the 3H and 3He mirror nuclei with the 11 GeV upgraded beam of Jefferson Lab. The measurement is expected to be almost free of nuclear effects, which introduce a significant uncertainty in the extraction of these two ratios from deep inelastic scattering off the proton and deuteron. The results are expected to test perturbative and non-perturbative mechanisms of spin-flavor symmetry breaking in the nucleon, and constrain the structure function parameterizations needed for the interpretation of high energy e-p, p-p and p-pbar collider data. The precision of the expected data can also allow for testing competing parameterizations of the nuclear EMC effect and provide valuable constraints on models of its dynamical origin.

  3. Lattice NRQCD study of S- and P-wave bottomonium states in a thermal medium with $N_f=2+1$ light flavors

    E-Print Network [OSTI]

    Seyong Kim; Peter Petreczky; Alexander Rothkopf

    2014-09-12T23:59:59.000Z

    We investigate the properties of S-and P-wave bottomonium states in the vicinity of the deconfinement transition temperature. The light degrees of freedom are represented by dynamical lattice QCD configurations of the HotQCD collaboration with $N_f = 2 + 1$ flavors. Bottomonium correlators are obtained from bottom quark propagators, computed in Non-Relativistic QCD (NRQCD) under the background of these gauge field configurations. The spectral functions for the $^3S_1$ ($\\Upsilon$) and $^3P_1$ ($\\chi_{b1}$) channel are extracted from the Euclidean time correlators using a novel Bayesian approach in the temperature region $140 {\\rm MeV} \\le T \\le 249 {\\rm MeV}$ and the results are contrasted to those from the standard Maximum Entropy Method. We find that the new Bayesian approach is far superior to the Maximum Entropy Method and enables us to study reliably the first peak in the spectral functions even under the limitations present in the finite temperature setup. We find that $\\chi_{b1}$ survives up to $T=249 {\\rm MeV}$, the highest temperature considered in our study and put stringent constraints on the size of the medium modification of $\\Upsilon$ and $\\chi_{b1}$ states.

  4. Leptonic decay constants fK, fD and fDs with Nf = 2+1+1 twisted-mass lattice QCD

    E-Print Network [OSTI]

    N. Carrasco; P. Dimopoulos; R. Frezzotti; P. Lami; V. Lubicz; F. Nazzaro; E. Picca; L. Riggio; G. C. Rossi; F. Sanfilippo; S. Simula; C. Tarantino

    2015-02-25T23:59:59.000Z

    We present a lattice QCD calculation of the pseudoscalar decay constants fK, fD and fDs performed using the gauge configurations produced by the European Twisted Mass Collaboration with Nf = 2 + 1 + 1 dynamical quarks, which include in the sea, besides two light mass degenerate quarks, also the strange and charm quarks with masses close to their values in the real world. The simulations are based on a unitary setup for the two light mass-degenerate quarks and on a mixed action approach for the strange and charm quarks. We use data simulated at three different values of the lattice spacing in the range 0.06 - 0.09 fm and at pion masses in the range 210 - 450 MeV. Our main results are: fK+ / fpi+ = 1.184 (16), fK+ = 154.4 (2.0) MeV, which incorporate the leading strong isospin breaking correction due to the up- and down-quark mass difference, and fK = 155.0 (1.9) MeV, fD = 207.4 (3.8) MeV, fDs = 247.2 (4.1) MeV, fDs / fD = 1.192 (22) and (fDs / fD) / (fK / fpi) = 1.003 (14) obtained in the isospin symmetric limit of QCD. Combined with the experimental measurements of the leptonic decay rates of kaon, pion, D- and Ds-mesons our results lead to the following determination of the CKM matrix elements: |Vus| = 0.2269 (29), |Vcd| = 0.2221 (67) and |Vcs| = 1.014 (24). Using the latest value of |Vud| from superallowed nuclear beta decays the unitarity of the first row of the CKM matrix is fulfilled at the permille level.

  5. The REMOTE SENSlNf

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA group currentBradleyTableSelling7 AugustAFRICAN3uj: ;;IDEC. i' , i Department_''1

  6. FS Mtg. Minutes Faculty Senate meeting Minutes

    E-Print Network [OSTI]

    Gering, Jon C.

    the Budget Committee. B. Jones proposed a slate of members for the Budget Committee. He suggested made a motion to appoint the suggested slate of members to the Budget Committee. F. Piper seconded

  7. BERNER CHEMISCHE GESELLSCHAFT Vortrge FS 2014

    E-Print Network [OSTI]

    Mühlemann, Oliver

    Laboratory "Solar Thermochemical Fuel Production via Metal Oxide Redox Cycles" Kaffee ab 16:10 Uhr vor dem and Habitability, Universität Bern) 07.05.2014 Prof. Aldo Steinfeld Paul Scherrer Institut, Solar Technology

  8. Publications New NM FS Scientific Reports Published

    E-Print Network [OSTI]

    Gulf of Mexico estuarine inventory and study- Texas: Area description." September 1975. 129 p. ABSTRACT and benthic properties; pop- ulations and economic development; pollution; and navigation projects hunting. Pollution from domestic and in- dustrial sources has forced the closing of about 325,090 acres

  9. Microsoft Word - Final FS ROD.doc

    National Nuclear Security Administration (NNSA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilAElectronic Input Options Gary L. Hirsch ProjectLyneis,Nevada SNJVNEVADA

  10. IL FS Ecosmart Ltd | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are8COaBulkTransmissionSitingProcess.pdfGetecGtel JumpCounty, Texas: EnergyHy9MoatEnergyElectricity AccessIFBEcosmart

  11. oetd_fs_trp1.indd

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 Russian Nuclearand Characterization ofC u r r e n t I s s u e s C u r r eFORM

  12. Microsoft Word - CERCLA FS-final.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes |IsLove Your HomeOverviewCleanupShippingFacility WorkSHEET U.S.

  13. Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-{kappa}B translocation

    SciTech Connect (OSTI)

    Jawan, Bruno [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Kao, Y.-H. [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Department of Biological Sciences, National Sun Yat-Sen University, 70 Lien-Hai Road, Kaohsiung 804, Taiwan (China); Goto, Shigeru [Department of Surgery and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Department of Surgery, Iwao Hospital, 3059-1 Kawakami, Yufuin, Oita 879-5102 (Japan); Pan, M.-C. [Department of Anesthesiology and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Lin, Y.-C.; Hsu, L.-W.; Nakano, Toshiaki; Lai, C.-Y.; Sun, C.-K.; Cheng, Y.-F. [Department of Surgery and Liver Transplantation Program, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan (China); Tai, M.-H. [Department of Biological Sciences, National Sun Yat-Sen University, 70 Lien-Hai Road, Kaohsiung 804, Taiwan (China); Department of Medical Research and Education, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Road, Kaohsiung 813, Taiwan (China)] (and others)

    2008-06-15T23:59:59.000Z

    Propofol (PPF), a widely used intravenous anesthetic for induction and maintenance of anesthesia during surgeries, was found to possess suppressive effect on host immunity. This study aimed at investigating whether PPF plays a modulatory role in the lipopolysaccharide (LPS)-induced inflammatory cytokine expression in a cell line of rat hepatocytes. Morphological observation and viability assay showed that PPF exhibits no cytotoxicity at concentrations up to 300 {mu}M after 48 h incubation. Pretreatment with 100 {mu}M PPF for 24 h prior to LPS stimulation was performed to investigate the modulatory effect on LPS-induced inflammatory gene production. The results of semi-quantitative RT-PCR demonstrated that PPF pretreatment significantly suppressed the LPS-induced toll-like receptor (TLR)-4, CD14, tumor necrosis factor (TNF)-{alpha}, and granulocyte-macrophage colony-stimulating factor (GM-CSF) gene expression. Western blotting analysis showed that PPF pretreatment potentiated the LPS-induced TLR-4 downregulation. Flow cytometrical analysis revealed that PPF pretreatment showed no modulatory effect on the LPS-upregulated CD14 expression on hepatocytes. In addition, PPF pretreatment attenuated the phosphorylation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and I{kappa}B{alpha}, as well as the nuclear translocation of NF-{kappa}B primed by LPS. Moreover, addition of PD98059, a MAPK kinase inhibitor, significantly suppressed the LPS-induced NF-{kappa}B nuclear translocation and GM-CSF production, suggesting that the PPF-attenuated GM-CSF production in hepatocytes may be attributed to its suppressive effect on MAPK/ERK signaling pathway. In conclusion, PPF as an anesthetic may clinically benefit those patients who are vulnerable to sepsis by alleviating sepsis-related inflammatory response in livers.

  14. D-Saccharic acid 1,4-lactone protects diabetic rat kidney by ameliorating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via NF-?B and PKC signaling

    SciTech Connect (OSTI)

    Bhattacharya, Semantee [Department of Life Sciences and Biotechnology, Jadavpur University, 188, Raja S C Mullick Road, Kolkata 700 032 (India); Manna, Prasenjit [Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata-700054 (India); Gachhui, Ratan [Department of Life Sciences and Biotechnology, Jadavpur University, 188, Raja S C Mullick Road, Kolkata 700 032 (India); Sil, Parames C., E-mail: parames@bosemain.boseinst.ac.in [Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata-700054 (India)

    2013-02-15T23:59:59.000Z

    Increasing evidence suggests that oxidative stress is involved in the pathogenesis of diabetic nephropathy (DN) and this can be attenuated by antioxidants. D-Saccharic acid 1,4-lactone (DSL) is known for its detoxifying and antioxidant properties. Our early investigation showed that DSL can ameliorate alloxan (ALX) induced diabetes mellitus and oxidative stress in rats by inhibiting pancreatic ?-cell apoptosis. In the present study we, therefore, investigated the protective role of DSL against renal injury in ALX induced diabetic rats. ALX exposure (at a dose of 120 mg/kg body weight, i. p., once) elevated the blood glucose level, serum markers related to renal injury, the production of reactive oxygen species (ROS), and disturbed the intra-cellular antioxidant machineries. Oral administration of DSL (80 mg/kg body weight) restored all these alterations close to normal. In addition, DSL could also normalize the aldose reductase activity which was found to increase in the diabetic rats. Investigating the mechanism of its protective activity, we observed the activation of different isoforms of PKC along with the accumulation of matrix proteins like collagen and fibronectin. The diabetic rats also showed nuclear translocation of NF-?B and increase in the concentration of inflammatory cytokines in the renal tissue. The activation of mitochondria dependent apoptotic pathway was observed in the diabetic rat kidneys. However, treatment of diabetic rats with DSL counteracted all these changes. These findings, for the first time, demonstrated that DSL could ameliorate renal dysfunction in diabetic rats by suppressing the oxidative stress related signalling pathways. - Highlights: ? Sustained hyperglycemia and oxidative stress lead to diabetic renal injury. ? D-saccharic acid 1,4-lactone prevents renal damage in alloxan-induced diabetes. ? It restores intra-cellular antioxidant machineries and kidney apoptosis. ? DSL reduces hyperglycemia-mediated oxidative stress via NF-kB and PKC signaling. ? DSL may act as a beneficial agent in hyperglycemia induced renal disorder.

  15. Eu{sub 3}F{sub 4}S{sub 2}: Synthesis, crystal structure, and magnetic properties of the mixed-valent europium(II,III) fluoride sulfide EuF{sub 2}.(EuFS){sub 2}

    SciTech Connect (OSTI)

    Grossholz, Hagen; Hartenbach, Ingo [Institut fuer Anorganische Chemie, Universitaet Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart (Germany); Kotzyba, Gunter [Institut fuer Anorganische und Analytische Chemie, Westfaelische Wilhelms-Universitaet Muenster, Corrensstrasse 30, 48149 Muenster (Germany); Poettgen, Rainer, E-mail: pottgen@uni-muenster.d [Institut fuer Anorganische und Analytische Chemie, Westfaelische Wilhelms-Universitaet Muenster, Corrensstrasse 30, 48149 Muenster (Germany); Trill, Henning; Mosel, Bernd D. [Institut fuer Physikalische Chemie, Westfaelische Wilhelms-Universitaet Muenster, Corrensstrasse 30, 48149 Muenster (Germany); Schleid, Thomas, E-mail: schleid@iac.uni-stuttgart.d [Institut fuer Anorganische Chemie, Universitaet Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart (Germany)

    2009-11-15T23:59:59.000Z

    Using the method to synthesize rare-earth metal(III) fluoride sulfides MFS (M=Y, La, Ce-Lu), in some cases we were able to obtain mixed-valent compounds such as Yb{sub 3}F{sub 4}S{sub 2} instead. With Eu{sub 3}F{sub 4}S{sub 2} another isotypic representative has now been synthesized. Eu{sub 3}F{sub 4}S{sub 2} (tetragonal, I4/mmm, a=400.34(2), c=1928.17(9) pm, Z=2) is obtained from the reaction of metallic europium, elemental sulfur, and europium trifluoride in a molar ratio of 5:6:4 within seven days at 850 deg. C in silica-jacketed gas-tightly sealed platinum ampoules. The single-phase product consists of black plate-shaped single crystals with a square cross section, which can be obtained from a flux using equimolar amounts of NaCl as fluxing agent. The crystal structure is best described as an intergrowth structure, in which one layer of CaF{sub 2}-type EuF{sub 2} is followed by two layers of PbFCl-type EuFS when sheeted parallel to the (001) plane. Accordingly there are two chemically and crystallographically different europium cations present. One of them (Eu{sup 2+}) is coordinated by eight fluoride anions in a cubic fashion, the other one (Eu{sup 3+}) exhibits a monocapped square antiprismatic coordination sphere with four F{sup -} and five S{sup 2-} anions. Although the structural ordering of the different charged europium cations is plausible, a certain amount of charge delocalization with some polaron activity has to take place, which is suggested by the black color of the title compound. Temperature dependent magnetic susceptibility measurements of Eu{sub 3}F{sub 4}S{sub 2} show Curie-Weiss behavior with an experimental magnetic moment of 8.19(5) mu{sub B} per formula unit and a paramagnetic Curie temperature of 0.3(2) K. No magnetic ordering is observed down to 4.2 K. In accordance with an ionic formula splitting like (Eu{sup II})(Eu{sup III}){sub 2}F{sub 4}S{sub 2} only one third of the europium centers in Eu{sub 3}F{sub 4}S{sub 2} carry permanent magnetic moments. {sup 151}Eu-Moessbauer spectroscopic experiments at 4.2 K show one signal at an isomer shift of -12.4(1) mm/s and a second one at 0.42(4) mm/s. These signals occur in a ratio of 1:2 and correspond to Eu{sup 2+} and Eu{sup 3+}, respectively. The spectra at 78 and 298 K are similar, thus no change in the Eu{sup 2+}/Eu{sup 3+} fraction can be detected. - Graphical abstract: Crystal structure and {sup 151}Eu-Moessbauer spectra of mixed-valent Eu{sub 3}F{sub 4}S{sub 2}.

  16. Quine's NF---60 years on Thomas Forster

    E-Print Network [OSTI]

    Forster, T.E.

    twentieth century mathematicians used the expression ``The Crisis in Foundations''. This crisis had many in the form of Russell's paradox, appropriately in the heart of set theory. At first blush one might think

  17. Australian National University Delegations Category ID: F&S06

    E-Print Network [OSTI]

    Botea, Adi

    Delegations SERVICE Service contracts Y 269 Execute service contracts relating to gas, electricity, cleaning

  18. CEC-500-2010-FS-014 New Engine Technology for

    E-Print Network [OSTI]

    technology for CHP (Image credit: Tecogen, Inc.) The Issue Small-scale combined heat and power (CHP) systems difficulty meeting the California's 2007 CHP emission standards. These inefficient engines also cause under-effective CHP systems 75 kilowatt (kW) are needed to address significant market populations that have limited

  19. CPI'2009 Fs, Maroc Intelligence Golocalise MObile & COMmunicante

    E-Print Network [OSTI]

    Boyer, Edmond

    CPI'2009 ­ Fès, Maroc IGMoCom Intelligence Géolocalisée MObile & COMmunicante Frédéric Chaxel Internationale Conception et Production Integrées (CPI'2009), Fès : Maroc (2009)" #12;2 CPI'2009 2. Contexte Un

  20. CEC-500-2010-FS-002 Assess New Transportation

    E-Print Network [OSTI]

    2010 The Issue California's transportation sector is the single largest contributor of greenhouse gas change. California must find strategies to reduce greenhouse gas emissions from the transportation sector. Research addressing additional land-use measures, shifts to less carbon emitting modes, and new policies

  1. EIS-0005-FS-2: Final Environmental Impact Statement

    Broader source: Energy.gov [DOE]

    Bonneville Power Administration Proposed FY 1979 Program Facility Planning Supplement Southwest Oregon Area Service, Supplemental

  2. Microsoft Word - ATLAS WS 2014 FS report fnl

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    arrays such as the X-Array are well suited for these measurements. Neutrinoless double beta decay experiments will be key to determine the Majorana or Dirac nature of the...

  3. Universidad Simn Bolvar FS4111. 2do Parcial (35 %).

    E-Print Network [OSTI]

    Vásquez, Carlos

    , observamos que la transferencia de calor por mol, a la temperatura constante T0, está dada por: ¯dQ = Tds varía según la relación v = v0 + a(T - T0) + b(P - P0), siendo a y b constantes. Calcule el calor ¯d térmica (T, P), la compresibilidad isotérmica T (T, P) y el calor específico molar cp(T, P), funciones de

  4. CEC-500-2010-FS-XXX California Transportation

    E-Print Network [OSTI]

    Action Plan for California sets specific biofuels use targets in California to reduce dependence through the production of biofuels by California's agricultural sector. A stronger research and development initiative is necessary for the potential role of biofuels from energy crops to be accurately

  5. CEC-500-2010-FS-017 Volatility of Ultrafine Particulate

    E-Print Network [OSTI]

    Gas Vehicles TRANSPORTATION ENERGY RESEARCH PIER Transportation Research www. Limited research has been done to characterize compressed natural gas mass emissions and practically-volatile and semi-volatile fractions of ultrafine particulate matter emissions from compressed natural gas vehicles

  6. CEC-500-2010-FS-XXX Bacterial Fermentation of

    E-Print Network [OSTI]

    then converts the lipids into biodiesel, enabling rapid and efficient conversion of cellulosic solid waste into biodiesel fuel in a smallscale, lowcost processing facility. Menon and Associates propose to use wash Biodiesel Crude Biodiesel Refined Alcohol recycled to transesterification Biodiesel Raw Fuel

  7. CEC-500-2010-FS-001 Algae OMEGA

    E-Print Network [OSTI]

    ENERGY RESEARCH PIER Transportation Research www.energy.ca.gov/research/ transportation/ March 2010) emissions that result in global climate change. It is well known that microalgae can provide a significant,424 NASA For more information, please contact: David Effross California Energy Commission PIER Program

  8. CEC-500-2010-FS-018 Automotive Thermoelectric

    E-Print Network [OSTI]

    will also be achieved by incorporating thermoelectric waste heat generators into the system design to convert waste heat (exhaust gas) into electrical energy. PIER Program Objectives and Anticipated Benefits

  9. file://\\fs-f1\shared\uranium\uranium.html

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron4 Self-Scrubbing:,, , ., December 8,John Wagoner, Manager30/038/03

  10. File:1200CappFS.pdf | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are8COaBulkTransmissionSitingProcess.pdf Jump to: navigation, searchMTAMontanaEnvironmentalPolicyAct.pdf Jump

  11. Report: WR-FS-99-02 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn April 23, 2014, an OHASeptemberAssessments | DepartmentTheDepartment ofREPORTApril 7,

  12. Microsoft Word - 25788WDC_DOE DD FS.docx

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy ChinaofSchaeferApril 1,(EAC) Richard2015MountainLLCFebruary 2014 FebruaryZEROES HouZeJune

  13. Audit Report: ER-FS-99-01

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation38-06 Audit Report:2 Audit6

  14. Audit Report: ER-FS-99-03

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation38-06 Audit Report:2 Audit6U S.

  15. Audit Report: ER-FS-99-04

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation38-06 Audit Report:2 Audit6U S.

  16. BLM/FS Geothermal MOU | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to:EzfeedflagBiomass Conversions Inc JumpIM 2011-003 Jump to: Jump to:Management |Geothermal MOU

  17. Cloning and expression of equine NF-kB2

    E-Print Network [OSTI]

    Mirhosseini, Negin

    2009-05-15T23:59:59.000Z

    ., 2005). EIAV is transmitted mechanically by either an insect vector or an infected needle. EIAV causes a persistent infection which is typically classified in three defined stages: acute, chronic, and long-term asymptomatic (Leroux et al., 2001...). Initial exposure of an animal to a virulent strain usually results in an acute disease (Leroux et al., 2004; Maury, 1998). The acute stage of disease usually resolves within a few days 1...

  18. NF kappa B expression and matrix metalloproteinase activity in hypertension

    E-Print Network [OSTI]

    Wu, Kwan-I

    2009-01-01T23:59:59.000Z

    J. Silica attenuates hypertension in Lyon hypertensive rats.to experimental hypertension. J. Exp. Med. 115(6):1173-1190,Hypertensive Rat. Hypertension 52(2):415-423, 2008. Fabunmi

  19. NF 3 , the greenhouse gas missing from Kyoto

    E-Print Network [OSTI]

    Prather, Michael J; Hsu, Juno

    2008-01-01T23:59:59.000Z

    Moreover, there is an economic incentive, a tradeoff betweenthere are economic as well as environmental incentives not

  20. Distinct functions of negative regulators of NF-kappaB

    E-Print Network [OSTI]

    Kearns, Jeffrey D.

    2009-01-01T23:59:59.000Z

    Kearns JD, Cheong R, Hoffmann A, Levchenko A. (2005) “S, Werner SL, Huang CS, Hoffmann A. (2006) “I?B? providesWare CF, Ghosh G, Verma IM, Hoffmann A. (2007) “A fourth I?B

  1. Distinct functions of negative regulators of NF-kappaB

    E-Print Network [OSTI]

    Kearns, Jeffrey D.

    2009-01-01T23:59:59.000Z

    J Immunol 174: 983-991. Emmerich F, Theurich S, Hummel M,specific (Doerre et al, 2005; Emmerich et al, 2003; Memet etDoerre et al, 2005; Emmerich et al, 2003; Memet et al, 1999;

  2. CMRR-NF Supplemental EIS Scoping Comments | National Nuclear Security

    National Nuclear Security Administration (NNSA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA groupTubahq.na.gov Office of the

  3. ARM - VAP Product - aerich1nf1turn

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa-AnomalousProductsabrfcabrfcprecip Documentation abrfc : XDC documentation

  4. ARM - VAP Product - aerich2nf1turn

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa-AnomalousProductsabrfcabrfcprecip Documentation abrfc : XDC

  5. Contact: G. Sam Foster, Station Director, at gfoster@fs.fed.us or (970) 498-1353 http://www.fs.fed.us/rmrs/

    E-Print Network [OSTI]

    awareness for centuries (like canaries in coal mines). Nest timing is an effective measure of environmental. However, as sensitive indicators of environmental problems, birds have been instrumental in raising public, scientists will also be able to study potential impacts of climate change on individual species, habitats

  6. Sensitive characterization of phase and amplitude semiconductor nonlinearities for broadband 20 fs excitation

    E-Print Network [OSTI]

    Keller, Ursula

    for broadband excitation. We find that the pump-induced phase changes at the exciton and in the continuum decay chopping and lock-in detection. In our setup, phase dynamics can be studied in a temporal window limited, we have studied phase and amplitude semiconductor nonlinearities for broadband excitation of ex

  7. VIP-FS: A Virtual, Parallel file System for High Performance Parallel and Distributed Computing *

    E-Print Network [OSTI]

    Kuzmanovic, Aleksandar

    -passing li- blclries only provide part of the support necessary for most high performan.ce distributed computing applzca- tzcjns - support for hagh speed parallel l/O is still lark- 211q. In this paper, we

  8. Pet Name _________________ Species _________________ Breed _________________ Color ___________ Date of Birth/Age _______________ Weight _________________ Gender: M MC F FS

    E-Print Network [OSTI]

    Langerhans, Brian

    a history of: Loose stool, diarrhea or vomiting Respiratory illness ­ nasal discharge, coughing, sneezing

  9. Retailers and Distributors CEC-400-2012-FS-005-En Updated 3/6/2012

    E-Print Network [OSTI]

    helped the State stabilizeper-capitaelectricity consumption during a time that electricity use Efficiency Regulations Mean to Your Business What You Need to Know If you sell or offer new electricity stringent efficiency standards? With electricity and water supplies at a premium, California's Appliance

  10. Universidad Simn Bolvar FS2211 2do Parcial (30 %) Bloque C

    E-Print Network [OSTI]

    Vásquez, Carlos

    ), la distancia a cualquier punto del aro +Q es R+ = a2 + z2 (centro en el origen). La distancia a cualquier punto del aro +2Q será R+2 = b2 + z2. Siendo las distancias R+ y R- constantes en las respectivas.] Calcule el trabajo realizado por el agente externo para introducir el dieléctrico en el capacitor C2

  11. Appel contributions L'Universit Euro-Mditerranenne de Fs et l'Institut

    E-Print Network [OSTI]

    Oxford, University of

    tendances. L'atelier Au cours de la seconde moitié du siècle dernier, le Maroc est devenu l'un des concerne les migrations qualifiées. Depuis 1995, le Maroc a ainsi devancé la Turquie comme principale source de main-d'oeuvre immigrée en Europe. Cependant, le rôle du Maroc dans le système migratoire euro

  12. Generation of sub-30-fs microjoule mid-infrared pulses for ultrafast vibrational

    E-Print Network [OSTI]

    Borguet, Eric

    compression. http://dx.doi.org/10.1364/OL.38.005008 Understanding ultrafast interactions in solids and con]. The dispersion properties of certain nonlinear optical materials, such as potassium titanyl phosphate (KTP), lithium niobate (LNB), potassium niobate (KNB), and periodically poled stoichiometric lithium tantalate

  13. Transient lattice dynamics in fs-laser-excited semiconductors probed by ultrafast x-ray diffraction

    E-Print Network [OSTI]

    von der Linde, D.

    K. Sokolowski-Tinten , M. Horn von Hoegen, D. von der Linde Inst. for Laser- and Plasmaphysics Hannover, Germany #12;K. Sokolowski-Tinten, M. Horn von Hoegen, D. von der Linde, A. Cavalleri, C.W. Siders

  14. Image Source: http://activefiremaps.fs.fed.us Daily Wildfire Update

    E-Print Network [OSTI]

    in the area and within the fire perimeter, microwave towers, transmission lines Significant Events: The CSFS

  15. Guia de Fontes da uFsC Onde e como achar informaes cientficas

    E-Print Network [OSTI]

    Floeter, Sergio Ricardo

    a Plataforma Lattes, base de dados organizada pelo CNPq, que reúne currículos de pesquisadores e professores: Margareth Vianna Rossi Claussen (Colaboração Técnica UFF/UFSC) Coleta de dados e organização (jornalistas da das instituições de ciência e tecnologia. A coleta de dados foi efetivada a partir da lista de

  16. UC FS University of California San Francisco Emergency Response Management Plan

    E-Print Network [OSTI]

    Derisi, Joseph

    HL: Hot Lines HSEM Chris Jones 7/01/12 Appendix ICP: Incident Command Posts (New) HSEM Chris Jones 12 Medical Center HCC 1 PD Command Vehicle 1 PD Division Captains 1 PD Professional Standards Lieutenant 1: Crisis Management Response Team (New) HSEM Chris Jones 8/15/13 Appendix HL: Hot Lines HSEM Chris Jones 8

  17. ----NEST 80fS /

    E-Print Network [OSTI]

    Galef Jr., Bennett G.

    to the behavior 01 wild rats in natural environments lor two reasons. First, the animals in .U '. eTbe research

  18. Portsmouth RI/FS Report for the Process Buildings and Complex...

    Broader source: Energy.gov (indexed) [DOE]

    and Feasibility Study Report for the Process Buildings and Complex Facilities Decontamination and Decommissioning Evaluation Project at the Portsmouth Gaseous Diffusion Plant,...

  19. CEC-500-2011-FS-XXX Assessment of Particulate Matter

    E-Print Network [OSTI]

    , which will include a compressed natural gas car. The physical, chemical, and toxicological properties of emissions from the compressed natural gas car will be compared with emissions from other fuel types for Various Fuel Types PIER Transportation Research www.energy.ca.gov/research/transportation May 2011

  20. Financial Statement: OAS-FS-13-10 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 Russian NuclearandJunetrackEllen|JulyR--FOIADepartmentJuly 16, 20156,FinancialOUO

  1. File:FS Form 2800-16.pdf | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnualPropertyd8c-a9ae-f8521cbb8489 NoEurope BVEnergy3(2009).pdfForm 2800-16.pdf Jump to: navigation,

  2. Audit Report: CR-FS-99-01 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdf MoreAttendance2November 14, 1997April

  3. Audit Report: ER-FS-99-03 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober 22, 1996 Audit

  4. Audit Report: ER-FS-99-04 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober 22, 1996 Audit7, 1999 Results of

  5. Audit Report: IG-FS-98-01 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28,

  6. Audit Report: OAS-FS-06-01 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28, U.S. Department4,

  7. Audit Report: OAS-FS-07-02 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28, U.S.

  8. Audit Report: OAS-FS-08-02 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28, U.S.9, 2007

  9. Audit Report: OAS-FS-08-04 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28, U.S.9,

  10. Audit Report: OAS-FS-09-01 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28, U.S.9,Report on

  11. Audit Report: OAS-FS-09-02 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28, U.S.9,Report

  12. Audit Report: OAS-FS-09-03 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28,

  13. Audit Report: OAS-FS-09-06 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28,August 26, 2009

  14. Audit Report: OAS-FS-10-01 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28,August 26,

  15. Audit Report: OAS-FS-10-02 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28,August 26,12, 2009

  16. Audit Report: OAS-FS-10-03 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28,August 26,12,

  17. Audit Report: OAS-FS-10-05 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28,August

  18. Audit Report: OAS-FS-10-06 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28,AugustApril 21,

  19. Audit Report: OAS-FS-11-01 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28,AugustApril 21,12,

  20. Audit Report: OAS-FS-11-02 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28,AugustApril

  1. Audit Report: OAS-FS-11-04 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28,AugustApril1, 2010

  2. Audit Report: OAS-FS-11-05 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28,AugustApril1,

  3. Audit Report: OAS-FS-11-07 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober 28,AugustApril1,June

  4. Audit Report: OAS-FS-12-01 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober

  5. Audit Report: OAS-FS-12-02 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober15, 2011 Department of

  6. Audit Report: OAS-FS-12-03 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober15, 2011 Department

  7. Audit Report: OAS-FS-12-04 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober15, 2011

  8. Audit Report: OAS-FS-12-05 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober15, 2011February 6,

  9. Audit Report: OAS-FS-12-06 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober15, 2011February 6,8,

  10. Audit Report: OAS-FS-12-07 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober15, 2011February

  11. Audit Report: OAS-FS-12-09 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober15, 2011FebruaryJune

  12. Audit Report: OAS-FS-12-10 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober15,

  13. Audit Report: OAS-FS-13-02 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober15,September 7, 2012

  14. Audit Report: OAS-FS-13-04 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober15,September 7,

  15. Audit Report: OAS-FS-13-05 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober15,September 7,28,

  16. Audit Report: OAS-FS-13-10 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober15,September

  17. Audit Report: OAS-FS-15-05 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10 TheOctober15,SeptemberDecember

  18. Audit Report: OAS-FS-15-10 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:Whether you'reInc.:memo18.pdfOctober10

  19. Audit Report: WR-FS-99-03 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:WhetherNovember 13, 2009 Management Controls3,July2, 1995August4,1,May

  20. Audit Report: WR-FS-99-04 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy:WhetherNovember 13, 2009 Management Controls3,July2,

  1. Financial Statement: IG-FS-02-01 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy Chinaof EnergyImpactOnSTATEMENT OF DAVIDTheJuneGrid

  2. Financial Statement: OAS-FS-07-02 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy Chinaof EnergyImpactOnSTATEMENT OF DAVIDTheJuneGrid13, 2006 Department of Energy's

  3. Financial Statement: WR-FS-00-01 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy Chinaof EnergyImpactOnSTATEMENT OF DAVIDTheJuneGrid13, 2006 Department of

  4. Finanacial Statement: WR-FS-99-01 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO2: FinalOffers New Training on Energy6 FederalofE: Bibliography of(PEIS)Finanacial

  5. Financial Statement: OAS-FS-07-02 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO2: FinalOffers New Training on Energy6 FederalofE:

  6. http://www.fs.fed.us/sopa/state-level.php?nv

    National Nuclear Security Administration (NNSA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilAElectronic Input Options Gary L. Hirsch SNLMaythemeansIHomeWastesOverview

  7. Southwestern Federal Power System's Fiscal Year 2011 Financial Statement Audit, OAS-FS-13-06

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO Overview OCHCO OverviewRepositoryManagement |Solar EnergySouth Carolina

  8. Portsmouth RI/FS Report for the Process Buildings and Complex Facilities

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011 Strategic2 OPAM615_CostNSAR - T enAmount forDecontamination and Decommissioning

  9. Audit Report: AP-FS-97-02 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed off Energy.gov. Are you0 ARRA NewslettersPartnership1/08 Attendance List7-26

  10. Southwestern Federal Power System's Fiscal Year 2010 Financial Statement Audit, OAS-FS-12-10

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently AskedEnergyIssues DOE's Nuclear EnergySmartOverview - 2015

  11. Finanacial Statement: WR-FS-09-03 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport inEnergy June 6-7, 2013 MeetingEA # 1440 FINALby Victor

  12. Finanacial Statement: WR-FS-99-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport inEnergy June 6-7, 2013 MeetingEA # 1440 FINALby Victor99-02 Finanacial

  13. Financial Statement: IG-FS-01-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport inEnergy June 6-7, 2013 MeetingEA # 1440 FINALbyFinancial Opportunities

  14. Financial Statement: WR-FS-09-04 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport inEnergy June 6-7, 2013 MeetingEA # 1440 FINALbyFinancialFinancial

  15. Audit Report: OAS-FS-11-06 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 Russian NuclearandJune 17,Agenda Agenda Agenda425, 2015UnionSeptemberMay

  16. Audit Report: OAS-FS-12-08 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 Russian NuclearandJune 17,Agenda Agenda Agenda425, 2015UnionSeptemberMayMarch 28,

  17. Audit Report: OAS-FS-15-02 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 Russian NuclearandJune 17,Agenda Agenda Agenda425,15, 201320,7, 2014 Department9,

  18. Audit Report OAS-FS-15-09 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment ofManual

  19. Audit Report: OAS-FS-13-06 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit Report:

  20. Audit Report: OAS-FS-13-07 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit Report:7

  1. Audit Report: OAS-FS-13-08 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit Report:78

  2. Audit Report: OAS-FS-13-09 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit Report:789

  3. Audit Report: OAS-FS-13-11 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit Report:7891

  4. Audit Report: OAS-FS-13-12 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit Report:78912

  5. Audit Report: OAS-FS-13-13 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit

  6. Audit Report: OAS-FS-14-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit1 Audit

  7. Audit Report: OAS-FS-14-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit1 Audit2

  8. Audit Report: OAS-FS-14-03 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit1 Audit23

  9. Audit Report: OAS-FS-14-04 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit1 Audit234

  10. Audit Report: OAS-FS-14-05 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit1 Audit2345

  11. Audit Report: OAS-FS-14-06 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit1 Audit23456

  12. Audit Report: OAS-FS-14-07 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit1 Audit234567

  13. Audit Report: OAS-FS-14-08 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit1

  14. Audit Report: OAS-FS-14-09 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit19 Audit

  15. Audit Report: OAS-FS-15-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit19 Audit1

  16. Audit Report: OAS-FS-15-03 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit19 Audit13

  17. Audit Report: OAS-FS-15-06 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit19 Audit136

  18. Audit Report: OAS-FS-15-07 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit19 Audit1367

  19. Audit Report: OAS-FS-15-08 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuels DataEnergyDepartmentWind Siting Articles aboutDepartment6 Audit19 Audit13678

  20. Portsmouth RI/FS Report for the Site-Wide Waste Disposition Evaluation

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

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  1. Audit Report: OAS-FS-15-04 | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed off Energy.gov. Are you0 ARRA NewslettersPartnership1/08DOE/IG-09305IG-07490-03 Audit10 Audit4 Audit

  2. Audit Report: OAS-FS-12-02 | Department of Energy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011AT&T, Inc.'s ReplyApplication of TrainingAMOIG-0743 AuditAudit Report:Audit Report:

  3. Audit Report: OAS-FS-13-03 | Department of Energy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011AT&T, Inc.'s ReplyApplication of TrainingAMOIG-0743 AuditAudit Report:Audit

  4. Financial Statement: IG-FS-01-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube|6721Energy 3_adv_battery.pdfFerrin MooreJuly

  5. Financial Statement: IG-FS-02-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube|6721Energy 3_adv_battery.pdfFerrin MooreJuly2-01 Financial Statement:

  6. Financial Statement: IG-FS-04-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube|6721Energy 3_adv_battery.pdfFerrin MooreJuly2-01 Financial Statement:4-02

  7. Financial Statement: IG-FS-CA-06-04 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube|6721Energy 3_adv_battery.pdfFerrin MooreJuly2-01 Financial

  8. Financial Statement: OAS-FS-13-10 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube|6721Energy 3_adv_battery.pdfFerrin MooreJuly2-01

  9. Financial Statement: WR-FS-00-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube|6721Energy 3_adv_battery.pdfFerrin MooreJuly2-010-02 Financial Statement:

  10. Financial Statement: WR-FS-09-04 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube|6721Energy 3_adv_battery.pdfFerrin MooreJuly2-010-02 Financial

  11. Department of Energy's Fiscal Year 2011 Consolidated Financial Statements,OAS-FS-12-02

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny:Revised Finding of No53197E T A * S H I E L D * A L ALGAL 2010-07Department

  12. Department of Energy's Fiscal Year 2012 Consolidated Financial Statement, OAS-FS-13-04

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny:Revised Finding of No53197E T A * S H I E L D * A L ALGAL 2010-07Department2

  13. Audit Report: OAS-FS-13-01 | Department of Energy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 111 1,613Portsmouth SitePresentationsMarketing80.pdf18.pdf2).pdf1/081 Audit4601792 Audit75101

  14. Audit Report: OAS-FS-13-03 | Department of Energy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 111 1,613Portsmouth SitePresentationsMarketing80.pdf18.pdf2).pdf1/081 Audit4601792 Audit7510123

  15. Microsoft Word - Final Report Package Transmittal - FY 2010 FS Management Letter.doc

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently Asked Questions forCheneyNovember S.Fluor-B&W (08-93) United States Government

  16. Finanacial Statement: WR-FS-09-03 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy China 2015of 2005 at Iowa Wind TurbineTuesday,LeftPictures (front toCleanup Ahead202-05May

  17. Finanacial Statement: WR-FS-99-02 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy China 2015of 2005 at Iowa Wind TurbineTuesday,LeftPictures (front toCleanupApril 7, 1999

  18. Risk Assessment in the RI/FS process, and derivation of cleanup levels

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection TechnicalResonantNovember 15 to March 15A MegawattElectricity:

  19. Scoping Document: Quarry Residuals Remedial Investigation/Feasibility Study (RI/FS) Scoping Document.

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA group currentBradleyTableSelling7 AugustAFRICAN3u ;;;:: A'Salmon,

  20. Audit Report: IG-FS-96-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation38-06IG-0803IG-0893 Audit6-01 Audit

  1. Audit Report: IG-FS-97-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation38-06IG-0803IG-0893 Audit6-01

  2. Audit Report: IG-FS-99-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation38-06IG-0803IG-0893 Audit6-019-01

  3. Audit Report: OAS-FS-11-03 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation38-06IG-0803IG-08931

  4. Audit Report: OAS-FS-15-04 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName

  5. Audit Report: WR-FS-96-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName4 AuditM-15-03RA-L-12-06 Audit5-0849-03Audit

  6. Audit Report: WR-FS-97-03 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName4 AuditM-15-03RA-L-12-06 Audit5-0849-03Audit3

  7. Audit Report: WR-FS-97-04 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName4 AuditM-15-03RA-L-12-06 Audit5-0849-03Audit34

  8. Audit Report: WR-FS-99-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName4 AuditM-15-03RA-L-12-06

  9. Audit report: ER-FS-99-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName4Services Requirements DiscussedEnergy'sreport:

  10. Audit Report: OAS-FS-13-01 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy China U.S. Department ofJune 2, 2015 The Status ofBerylliumJune 18,February

  11. Audit Report: OAS-FS-13-03 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy China U.S. Department ofJune 2, 2015 The Status ofBerylliumJune 18,FebruaryNovember 15,

  12. Audit Report: ER-FS-99-01 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube platform is alwaysISOSource1-01 Audit Letter Report:38 Audit4 Audit1 Audit

  13. Audit Report: OAS-FS-11-03 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube platform is alwaysISOSource1-01 Audit Letter Report:38 Audit468155704211 Audit23

  14. Audit Report: OAS-FS-11-06 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube platform is alwaysISOSource1-01 Audit Letter Report:38 Audit4681557042115

  15. Audit Report: OAS-FS-13-09 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube platform is alwaysISOSource1-01 Audit Letter Report:389 Audit Report:105

  16. Audit Report: OAS-FS-14-06 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube platform is alwaysISOSource1-01 Audit Letter Report:389 Audit Report:10510

  17. Audit Report: OAS-FS-15-02 | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube platform is alwaysISOSource1-01 Audit Letter Report:389 Audit

  18. USDA-FS-EA-NV-030-06-025 2007 | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro IndustriesTown of Ladoga, IndianaTurtle Airships JumpTypefor

  19. USFS Electric Transmission Line Easement Form FS-2700-31 | Open Energy

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro IndustriesTown of Ladoga, IndianaTurtle Airships JumpTypeforUSDOI - Memorandum 37005 Jump

  20. Audit Report: ER-FS-99-01 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy China U.S. Department ofJune 2, 2015 The Status of Cleanup at theMay 25, 1999 Results of

  1. Insights into the regulation of NF-kappaB and mediation of the cellular stress response by NF-kappaB

    E-Print Network [OSTI]

    Ho, Jessica Q.

    2010-01-01T23:59:59.000Z

    Cancer Res 65, 4273-4281. Hoffmann, A. , Natoli, G. , andS.L. , Huang, C.S. , and Hoffmann, A. (2006). IkappaBepsilonK.I. , DiDonato, J.A. , Hoffmann, A. , Hardwick, J.M. , and

  2. Data Package of Samples Collected for Hydrogeologic and Geochemical Characterization: 300 Area RI/FS Sediment Cores

    SciTech Connect (OSTI)

    Lindberg, Michael J.; Bjornstad, Bruce N.; Lanigan, David C.; Williams, Benjamin D.

    2011-05-01T23:59:59.000Z

    This is a data package for sediment samples received from the 300 FF 5 OU. This report was prepared for CHPRC. Between August 16, 2010 and April 25, 2011 sediment samples were received from 300-FF-5 for geochemical studies. The analyses for this project were performed at the 331 building located in the 300 Area of the Hanford Site. The analyses were performed according to Pacific Northwest National Laboratory (PNNL) approved procedures and/or nationally recognized test procedures. The data sets include the sample identification numbers, analytical results, estimated quantification limits (EQL), and quality control data. The preparatory and analytical quality control requirements, calibration requirements, acceptance criteria, and failure actions are defined in the on-line QA plan 'Conducting Analytical Work in Support of Regulatory Programs' (CAW). This QA plan implements the Hanford Analytical Services Quality Assurance Requirements Documents (HASQARD) for PNNL.

  3. VERIFICATION SURVEY ACTIVITIES IN FS SURVEY UNITS 7, 8, 9, 10, 11, 13 & 14 AT THE SEPARATIONS PROCESS RESEARCH UNIT

    SciTech Connect (OSTI)

    M.G. JADICK

    2010-05-26T23:59:59.000Z

    FINAL INTERIM REPORT VERIFICATION SURVEY ACTIVITIES IN FINAL STATUS SURVEY UNITS 7, 8, 9, 10, 11, 13 AND 14 AT THE SEPARATIONS PROCESS RESEARCH UNIT, Niskayuna, New York 0496-SR-03-0. The Separations Process Research Unit (SPRU) facilities were constructed in the late 1940s to research the chemical separation of plutonium and uranium. SPRU operated between February 1950 and October 1953. The research activities ceased following the successful development of the reduction/oxidation and plutonium/uranium extraction processes that were subsequently used by the Hanford and the Savannah River sites.

  4. 227-fs pulses from a mode-locked Yb:LuScO3 thin disk laser

    E-Print Network [OSTI]

    Keller, Ursula

    ,1 Oliver H. Heckl,1 Matthias Golling,1 Thomas Südmeyer,1 Rigo Peters,2 Klaus Petermann,2 Günter. Bauer, J. Zhang, A. Killi, J. Kleinbauer, M. Kumkar, S. Weiler, M. Guina, D. H. Sutter, and T. Dekorsy

  5. NetDoFs of the MISO Broadcast Channel with Delayed CSIT Feedback for Finite Rate of

    E-Print Network [OSTI]

    Gesbert, David

    the main limiting factor in multi- user wireless communication systems. Tx side or Rx side zero-forcing (ZF by its industrial members: ORANGE, BMW Group, Swisscom, SFR, ST Microelectronics, Symantec, SAP, Monaco by the EU FP7 project METIS. delay is less than the channel coherence time. It was generally believed

  6. Inheritance of resistance to southern stem canker (Diaporthe phaseolorum f.s. meridionalis) in soybean [Glycine max (L.) Merr.

    E-Print Network [OSTI]

    Ngeleka, Kadima

    1990-01-01T23:59:59.000Z

    was relatively high when inoculation occurred during vege- tative stages VI through V3, compared with stages V6 through R2. No significant disease symptoms were observed on plants inoculated after the V12 stage of growth. This report may account for the higher..., the data were considered homogeneous. The pooled chi-square (X ) of 0. 24 (P & 0. 50) indicates that the Fz population fit a phenotypic ratio of 3:1. In the F, , the segregation pattern fit a 1:2:1 genotypic ratio (X =3. 24; P&0. 10). Table 6. Reaction...

  7. Universidad Simon Bolivar FS1112. 1er Parcial (30 %). Bloque B Departamento de Fisica Viernes, 22 de Noviembre de 2013

    E-Print Network [OSTI]

    Vásquez, Carlos

    despreciable para formar un cuerpo r´igido con brazos de igual longitud a. Dos de ellas est´an a una distancia apunta en direcci´on opuesta a la velocidad 1 La fuerza de roce es de tipo est´atica y no hace trabajo, y

  8. Assessing the potential of SeaWiFS and MODIS for estimating chlorophyll concentration in turbid productive waters

    E-Print Network [OSTI]

    Gitelson, Anatoly

    purpose of this study was to evaluate the extent to which near-infrared (NIR) to red reflectance ratios productive waters using red and near-infrared bands Giorgio Dall'Olmoa,b,*, Anatoly A. Gitelsona,b , Donald C estimation of Chl in turbid productive waters has so far not been feasible from satellite sensors. The main

  9. On the Accuracy of SeaWiFS Ocean Color Data Products on the West Florida Shelf

    E-Print Network [OSTI]

    products were evaluated. The in situ data covered a wide dynamic range, with about one order of magnitude. Econom- ically and ecologically, this region is highly important given the numerous commercial and recreational fisheries as well as tourism, shipping, and mining/petroleum industries located here

  10. Inheritance of resistance to southern stem canker (Diaporthe phaseolorum f.s. meridionalis) in soybean [Glycine max (L.) Merr.] 

    E-Print Network [OSTI]

    Ngeleka, Kadima

    1990-01-01T23:59:59.000Z

    canker. Results from the study showed that resistance to stem canker in both Crockett and Dowling was inherited as a dominant character, while F2 phenotypic and F/3 genotypic ratios suggested that resistance in boih cull ivars was determined by single... with fungicides before planting (2, 3). -Crop rotation of at least two years can be helpful to control stem canker, pro- vided crops such as cotton, a potential host for the fungus, are avoided (3, 30). -Cultivar reaction can be used to limit damage by stem...

  11. Hydrometeorological relationships on Haig Glacier, Alberta, J.M. SHEA,* F.S. ANSLOW, S.J. MARSHALL

    E-Print Network [OSTI]

    . Using a detrended-temperature indexed melt model, we assess the transport efficiency of the glacial hydrologic system through a comparison of total modelled daily melt and observed discharge. Transport efficiency values support the notion of a purge effect during freezing events and at the end of the ablation

  12. Universidad Simn Bolvar FS2211 1er Parcial (30 %) Bloque B Departamento de Fsica Mircoles, 30 de Enero de 2013

    E-Print Network [OSTI]

    Vásquez, Carlos

    = +Q = +10-6 C; el valor de q2 queda por determinar. La masa de la carga de prueba es m0. q2 q1 q3 -q0.] Determine el campo eléctrico E en todas las regiones del espacio. (c) [2 pts.] Determine las densidades de

  13. http://www.fs.usda.gov/wps/portal/fsinternet/!ut/p/c5/04_SB8K8x

    National Nuclear Security Administration (NNSA)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilAElectronic Input Options Gary L. Hirsch

  14. The Federal Energy Regulatory Commission's Fiscal Year 2012 Financial Statement Audit, OAS-FS-13-03

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently AskedEnergyIssuesEnergy Solar Decathlon2001 PowerofUse ofManagement8 BudgetFederal

  15. The Federal Energy Regulatory Commission's Fiscal Year 2011 Financial Statement Audit, OAS-FS-12-01

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn April 23,EnergyChicopeeTechnology Performance April 7,U.Future5 Budget1 Financial

  16. Audit of Departmental Integrated Standardized Core Accounting System (DISCAS) Operations at Selected Field Sites, AP-FS-97-02

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName4Services Requirements Discussed In AUDIT OF

  17. The Aoki phase for N_f=2 Wilson fermions revisited

    E-Print Network [OSTI]

    Sternbeck, A; Kerler, W; Müller-Preussker, M; Stüben, H

    2004-01-01T23:59:59.000Z

    We report on a numerical reinvestigation of the Aoki phase in full lattice QCD with two flavors of unimproved Wilson fermions. For zero temperature the Aoki phase can be confirmed at inverse coupling $\\beta=4.0$ and $\\beta=4.3$, but not at $\\beta=4.6$ and $\\beta=5.0$. At non-zero temperature the Aoki phase was found to exist also at $\\beta=4.6$.

  18. A partially quenched analysis of the eta-eta' system in N_f=2 QCD

    E-Print Network [OSTI]

    Neff, H; Negele, John W; Schilling, K; Lippert, Th.

    2004-01-01T23:59:59.000Z

    We report on a first, comprehensive partially quenched study of the eta-eta' problem, based on SESAM configurations on a 16^3x32 lattice at beta=5.6 QCD with two (mass degenerate) active sea quark flavours. By means of the spectral approximation of the two-loop (hairpin) diagrams, we find clear plateau formation in the effective masses which enables us both to determine the eta-eta' mass matrix and the alpha-parameter in the effective chiral Lagrangian for the flavour singlet sector, alpha=0.028 +- 0.013.

  19. Probing the Aoki phase with N_f=2 Wilson fermions at finite temperature

    E-Print Network [OSTI]

    Ilgenfritz, E M; Müller-Preussker, M; Sternbeck, A; Stüben, H

    2005-01-01T23:59:59.000Z

    In this letter we report on a numerical investigation of the Aoki phase in the case of finite temperature which continues our former study at zero temperature. We have performed simulations with Wilson fermions at $\\beta=4.6$ using lattices with temporal extension $N_{\\tau}=4$. In contrast to the zero temperature case, the existence of an Aoki phase can be confirmed for a small range in $\\kappa$ at $\\beta=4.6$, however, shifted slightly to lower $\\kappa$. Despite fine-tuning $\\kappa$ we could not separate the thermal transition line from the Aoki phase.

  20. NF-[kappa]B RelB/p52 heterodimer : biogenesis and DNA recognition

    E-Print Network [OSTI]

    Fusco, Amanda J.

    2007-01-01T23:59:59.000Z

    derived factor-1 (SDF-1), B lymphocyte chemoattractant (BLC)Sequence Consensus ELC BLC SDF-1 New Consensus for RelB/p52from the CD39, BLC, ELC and SDF-1 promoters (Figure 3-21).

  1. Gersende Prior NF-FE Meeting November 10th Neutrino Factory

    E-Print Network [OSTI]

    McDonald, Kirk

    long Hg target in 20 T field (SPL+accumulator & compressor ring). Decay: 30 m long in 1.8 T. Rotation the relations: = = ½ = 0 (can we ?) Problems: det(0 ) = 0 2x2 sub to understand the problems or change to a "real" optics code (MAD-X, OPTIM, PATH). - pros: ICOOL not designed

  2. www.nasa.gov/aeronautics NF-2013-05-565-HQ

    E-Print Network [OSTI]

    , emissions and fuel burn. A greener future for aviation holds the promise of new life for airports, because Headquarters 300 E. Street, SW Washington, DC 20546 NASA Facts Green Aviation: A Better Way to Treat the Planet engine emissions, unprecedented traffic jams in the sky, nonstop noise near airports, and more citizens

  3. Effects of water chemistry on NF/RO membrane structure and performance

    E-Print Network [OSTI]

    Mo, Yibing

    2013-01-01T23:59:59.000Z

    contaminants by a membrane bioreactor‚granular activatedA combination of a membrane bioreactor (MBR) and GAC for

  4. Effects of water chemistry on NF/RO membrane structure and performance

    E-Print Network [OSTI]

    Mo, Yibing

    2013-01-01T23:59:59.000Z

    methyl tert-butyl ether (MTBE), benzene, ethylbenzene,TCE** Industrial C 2 HCl 3 MTBE** [48] Industrial C 5 H 12 O

  5. Results of radiological measurements taken in the Niagara Falls, New York, area (NF002)

    SciTech Connect (OSTI)

    Williams, J.K.; Berven, B.A.

    1986-11-01T23:59:59.000Z

    The results of a radiological survey of 100 elevated gamma radiation anomalies in the Niagara Falls, New York, area are presented. These radiation anomalies were identified by a mobile gamma scanning survey during the period October 3-16, 1984, and were recommended for an onsite survey to determine if the elevated levels of radiation may be related to the transportation of radioactive waste material to the Lake Ontario Ordnance Works for storage. In this survey, radiological measurements included outdoor gamma exposure rates at 1 m above the surface; outdoor gamma exposure rates at the surface, range of gamma exposure rates during scan; and uranium, radium, and thorium concentrations in biased surface soil samples. The results show 38 anomalies (35 located along Pletcher Road and 3 associated with other unreleated locations) were found to exceed Formerly Utilized Sites Remedial Action Program (FUSRAP) remedial action guidelines and were recommended for formal characterization surveys. (Since the time of this survey, remedial actions have been conducted on the 38 anomalies identified as exceeding FUSRAP guidelines, and the radioactive material above guidelines has been removed.) The remaining 62 anomalies are associated with asphalt driveways and parking lots, which used a phosphate slag material (previously identified as cyclowollastonite, synthetic CaSiO/sub 3/). This rocky-slag waste material was used for bedding under asphalt surfaces and in general gravel applications. Most of the contaminated soil and rock samples collected at the latter anomalies had approximately equal concentrations of /sup 226/Ra and /sup 238/U and, therefore, are not related to materials connected with the Niagara Falls Storage Site (NFSS), including material that was transported to the NFSS. 13 refs., 7 figs., 14 tabs.

  6. University Square Stratford 1 Salway Road, Stratford, London, United Kingdom, E15 1NF

    E-Print Network [OSTI]

    Cocea, Mihaela

    has fully automatic heating, ventilation and lighting controls which require no manual operation. See. There is no smoking permitted in the premises or grounds area of the USS Building including the garden. #12;4 2

  7. Effects of water chemistry on NF/RO membrane structure and performance

    E-Print Network [OSTI]

    Mo, Yibing

    2013-01-01T23:59:59.000Z

    regulated some PAHs in the drinking water, but only Benzo-a-water of7 ppb, 700 ppb, 1ppm, 10 ppm, respectively [45]. PAHs

  8. Identification of NF-kappaB responsive elements in follistatin related gene (FLRG) promoter

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    : electrophoresis mobility-shift assay FLRG: follistatin related gene FSRP: follistatin-related protein FSTL3 lymphocytic leukemia (B-CLL). FLRG (alternative names: follistatin- related protein, FSRP / follistatin-like-3

  9. A NF-kappaB temporal code to ensure specificity in inflammatory signaling

    E-Print Network [OSTI]

    Werner, Shannon L.

    2009-01-01T23:59:59.000Z

    Kearns, J. , Cheong, R. , Hoffmann, A. , and Levchenko, A.G. , Verma, I.M. , and Hoffmann, A. 2007. A fourth IkappaBWerner, S.L. , Regal, J. , Hoffmann, A. , and Levchenko, A.

  10. Temporal encoding and homeostatic control in the IKK- kappaNF-kappaB signaling system

    E-Print Network [OSTI]

    Barken, Derren

    2007-01-01T23:59:59.000Z

    Nature 415(6868): 180-3. Hoffmann, A. and D. Baltimore (Immunol Rev 210: 171-86. Hoffmann, A. , A. Levchenko, etScience 298(5596): 1241-5. Hoffmann, A. , G. Natoli, et

  11. akt-dependent nf-kappab activation: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    particles, which take energy from an internal replenishable energy depot or ambient medium and transduce it into useful work performed on the environment, in addition to...

  12. Review of NF-IDS Targets Work Programme Status C. Densham, RAL, 17 November 2009

    E-Print Network [OSTI]

    McDonald, Kirk

    and services ? e) Cost of mercury system ? f) Cost of remote handling systems including shielding required ? g & containment TD Stalled c) Studies of irradiation, heat loads and cooling of decay solenoid JB, PL Underway d) Heat loads and cooling of shielding PL Stalled e) Solenoid system engineering, magnetic loads PL

  13. attenuates nf-kappab-dependent icam-1: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and borehole acoustic models. The validity of the scheme is established using a 3D homogenous isotropic ... Krasovec, Mary L. 2003-01-01 29 THE ATTENUATED RAY TRANSFORM...

  14. A numerical reinvestigation of the Aoki phase with N_f=2 Wilson fermions at zero temperature

    E-Print Network [OSTI]

    Ilgenfritz, E M; Müller-Preussker, M; Sternbeck, A; Stüben, H

    2003-01-01T23:59:59.000Z

    We report on a numerical reinvestigation of the Aoki phase in lattice QCD with two flavors of Wilson fermions where the parity-flavor symmetry is spontaneously broken. For this purpose an explicitly symmetry-breaking source term $h\\bar{\\psi} i \\gamma_{5} \\tau^{3}\\psi$ was added to the fermion action. The order parameter $$ was computed with the Hybrid Monte Carlo algorithm at several values of $(\\beta,\\kappa,h)$ on lattices of sizes $4^4$ to $12^4$ and extrapolated to $h=0$. The existence of a parity-flavor breaking phase can be confirmed at $\\beta=4.0$ and $4.3,$ while we do not find parity-flavor breaking at $\\beta=4.6$ and 5.0.

  15. Vector and scalar form factors for K- and D-meson semileptonic decays from twisted mass fermions with Nf = 2

    E-Print Network [OSTI]

    S. Di Vita; B. Haas; F. Mescia; V. Lubicz; S. Simula; C. Tarantino

    2009-10-26T23:59:59.000Z

    We present lattice results for the form factors relevant in the K -> pion and D -> pion semileptonic decays, obtained from simulations with two flavors of dynamical twisted-mass fermions and pion masses as light as 260 MeV. For K -> pion decays we discuss the estimates of the main sources of systematic uncertainties, including the quenching of the strange quark, leading to our final result f+(0) = 0.9560 (57) (62). Combined with the latest experimental data, our value of f+(0) implies for the CKM matrix element |Vus| the value 0.2267 (5) (20) consistent with the first-row CKM unitarity. For D -> pion decays the application of Heavy Meson Chiral Perturbation Theory allows to extrapolate our results for both the scalar and the vector form factors at the physical point with quite good accuracy, obtaining a nice agreement with the experimental data. In particular at zero-momentum transfer we obtain f+(0) = 0.64 (5).

  16. Modulation of host NF-[k??a?p?p?a?]B pathway by the Toxoplasma gondii secreted factor, GRA15

    E-Print Network [OSTI]

    Lu, Diana, Ph. D. Massachusetts Institute of Technology

    2013-01-01T23:59:59.000Z

    The apicomplexan protozoan Toxoplasma gondii is an obligate intracellular pathogen that infects all warm blooded animals, including nearly thirty percent of the human population worldwide. Toxoplasma's success as a parasite ...

  17. On the Use of Thermal NF3 as the Fluorination and Oxidation Agent in Treatment of Used Nuclear Fuels

    SciTech Connect (OSTI)

    Scheele, Randall D.; McNamara, Bruce K.; Casella, Andrew M.; Kozelisky, Anne E.

    2012-05-01T23:59:59.000Z

    This paper presents results of our investigation on the use of nitrogen trifluoride as the fluorination or fluorination/oxidation agent for use in a process for separating valuable constituents from used nuclear fuels by employing the volatility of many transition metal and actinide fluorides. Nitrogen trifluoride is less chemically and reactively hazardous than the hazardous and aggressive fluorinating agents used to prepare uranium hexafluoride and considered for fluoride volatility based nuclear fuels reprocessing. In addition, nitrogen trifluoride’s less aggressive character may be used to separate the volatile fluorides from used fuel and from themselves based on the fluorination reaction’s temperature sensitivity (thermal tunability) rather than relying on differences in sublimation/boiling temperature and sorbents. Our thermodynamic calculations found that nitrogen trifluoride has the potential to produce volatile fission product and actinide fluorides from candidate oxides and metals. Our simultaneous thermogravimetric and differential thermal analyses found that the oxides of lanthanum, cerium, rhodium, and plutonium fluorinated but did not form volatile fluorides and that depending on temperature volatile fluorides formed from the oxides of niobium, molybdenum, ruthenium, tellurium, uranium, and neptunium. We also demonstrated near-quantitative removal of uranium from plutonium in a mixed oxide.

  18. Studies of resonantly produced plasmas in the H-1NF heliac using a far-infrared scanning interferometer

    E-Print Network [OSTI]

    Howard, John

    with an electric motor to provide a stable computer controlled rotational speed and to make the system acoustically and the other as a vibration monitor to compensate for wheel induced vibrations. With the grating wheel rotating and signal to noise ratio. We typically choose N 30. A Fourier shifting algorithm is used to correct

  19. QCD thermodynamics with $N_f=2+1$ near the continuum limit at realistic quark masses

    E-Print Network [OSTI]

    Takashi Umeda

    2006-10-03T23:59:59.000Z

    We report on our study of QCD thermodynamics with 2+1 flavors of dynamical quarks. In this proceeding we present several thermodynamic quantities and our recent calculation of the critical temperature. In order to investigate the thermodynamic properties of QCD near the continuum limit we adopt improved staggered (p4) quarks coupled with tree-level Symanzik improved glue on $N_t=4$ and 6 lattices. The simulations are performed with a physical value of the strange quark mass and light quark masses which are in the range of $m_q/m_s=0.05-0.4$. The lightest quark mass corresponds to a pion mass of about 150 MeV.

  20. I kappa B epsilon provides negative feedback to control NF-kappa B oscillations, signaling dynamics, and inflammatory gene expression

    E-Print Network [OSTI]

    Kearns, Jeffrey D; Basak, Soumen; Werner, Shannon L; Huang, Christine S; Hoffmann, Alexander

    2006-01-01T23:59:59.000Z

    Cancer Lett. 206: 193-199. Hoffmann, A. , and D. Baltimore.Immunol. Rev. 210:171-186. Hoffmann, A. , A. Levchenko, M.L.Science. 298:1241—1245. Hoffmann, A. , T.H. Leung, and D.

  1. P105 and p100 proteins function as the core of heterogeneous NF-kappaB complexes

    E-Print Network [OSTI]

    Savinova, Olga V.

    2009-01-01T23:59:59.000Z

    the p105 mutant protein that lacks a death domain, p105(1-and p105 mutant protein that lacks the C-terminal deaththat YFP-tagged p105 proteins that lack the ANK domain are

  2. I kappa B epsilon provides negative feedback to control NF-kappa B oscillations, signaling dynamics, and inflammatory gene expression

    E-Print Network [OSTI]

    Kearns, Jeffrey D; Basak, Soumen; Werner, Shannon L; Huang, Christine S; Hoffmann, Alexander

    2006-01-01T23:59:59.000Z

    Immunol. 174:983—991. Emmerich, F. , S. Theurich, M. Hummel,Spiecker et al. , 2000; Emmerich et al. , 2003; Doerre etSpiecker et al. , 2000; Emmerich et al. , 2003; Doerre et

  3. ineralization of acid and sweet whey. There would be about 150 000200 000 m2 of NF

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    properties [13]. In crossflow filtration of whey using organic membranes, the most important fouling to fouling. Some studies have demonstrated that the hydrodynamic operating conditions of mem- brane crossflow

  4. A R T I C L E p53 stabilization is decreased upon NF B activation: A role for

    E-Print Network [OSTI]

    Wahl, Geoffrey M.

    et al., 1995). Since transcrip-et al., 1996), and hypoxia (Graeber et al., 1994), lead to activation

  5. MODULATION OF THE NF-KAPPA B SIGNALING PATHWAY BY THE BACTERIAL TYPE III SECRETION SYSTEM EFFECTORS

    E-Print Network [OSTI]

    Gao, Xiaofei

    2012-08-31T23:59:59.000Z

    The type III secretion system (T3SS) is a bacterial injection system expressed by many Gram-negative bacteria. During the last two decades, the repertoire of T3SS effectors has been greatly explored, and several mechanisms ...

  6. Nucleon form factors and structure functions with N_f=2+1 dynamical domain wall fermions

    E-Print Network [OSTI]

    RBC-UKQCD Collaborations; :; Takeshi Yamazaki; Shigemi Ohta

    2007-10-02T23:59:59.000Z

    We report isovector form factors and low moments of structure functions of nucleon in numerical lattice quantum chromodynamics (QCD) from the on-going calculations by the RIKEN-BNL-Columbia (RBC) and UKQCD Collaborations with (2+1) dynamical flavors of domain-wall fermion (DWF) quarks. We calculate the matrix elements with four light quark masses, corresponding to pion mass values of m_\\pi = 330-670 MeV, while the dynamical strange mass is fixed at a value close to physical, on (2.7 fm)^3 spatial volume. We found that our axial charge, g_A, at the lightest mass exhibits a large deviation from the heavier mass results. This deviation seems to be a finite-size effect as the g_A value scales with a single parameter, m_\\pi L, the product of pion mass and linear spatial lattice size. The scaling is also seen in earlier 2-flavor dynamical DWF and Wilson quark calculations. Without this lightest point, the three heavier mass results show only very mild mass dependence and linearly extrapolate to g_A=1.16(6). We determined the four form factors, the vector (Dirac), induced tensor (Pauli), axial vector and induced pseudoscalar, at a few finite momentum transfer values as well. At the physical pion mass the form-factors root mean square radii determined from the momentum-transfer dependence %of the form factors are 20-30% smaller than the corresonding experiments. The ratio of the isovector quark momentum to helicity fractions, _{u-d}/_{\\Delta u - \\Delta d} is in agreement with experiment without much mass dependence including the lightest point. We obtain an estimate, 0.81(2), by a constant fit. Although the individual momentum and helicity fractions are yet to be renormalized, they show encouraging trend toward experiment.

  7. Functions of receptor activator of NF-?B ligand (RANKL) and its receptors, RANK and OPG, are evolutionarily conserved 

    E-Print Network [OSTI]

    Sutton, Kate Maurice

    2014-11-28T23:59:59.000Z

    The tumour necrosis factor (TNF) superfamily is a group of cytokines that orchestrate a variety of functions, both in the development of the architecture of immune organs and of the immune response. The mammalian TNF ...

  8. DETEW!INATION OF THE NEUTRON MAGNETIC FlONENT G.L. Greene and N.F. Ramsey

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power Administration wouldDECOMPOSITION OF CALCIUM SULFATE: A REVIEW OF THEDETEW!INATION OF THE

  9. Lake Roosevelt Fisheries Evaluation Program : Limnological and Fisheries Monitoring Annual Report 1999.

    SciTech Connect (OSTI)

    McLellan, Holly; Lee, Chuck; Scofield, Ben; Pavlik, Deanne

    1999-08-01T23:59:59.000Z

    The Grand Coulee Dam was constructed in 1939 without a fish ladder, which eliminated steelhead (Onchorhynchus mykiss), chinook salmon (O. twshwastica), coho salmon (O. kisutch) and sockeye salmon (O. nerka) from returning to approximately 1,835 km (1,140 miles) of natal streams and tributaries found in the upper Columbia River Drainage in the United States and Canada. The Pacific Northwest Electric Power Planning and Conservation Act of 1980 gave the Bonneville Power Administration (BPA), the authority and responsibility to use its legal and financial resources, 'to protect, mitigate, and enhance fish and wildlife to the extent affected by the development and operation of any hydroelectric project of the Columbia River and its tributaries. This is to be done in a manner consistent with the program adopted by the Northwest Power Planning Council (NWPPC), and the purposes of the Act' (NWPPC, 1987). With the phrase 'protect, mitigate and enhance', Congress signaled its intent that the NWPPC's fish and wildlife program should do more than avoid future hydroelectric damage to the basin's fish and wildlife. The program must also counter past damage, work toward rebuilding those fish and wildlife populations that have been harmed by the hydropower system, protect the Columbia Basin's fish and wildlife resources, and mitigate for harm caused by decades of hydroelectric development and operations. By law, this program is limited to measures that deal with impacts created by the development, operation and management of hydroelectric facilities on the Columbia River and its tributaries. However, off-site enhancement projects are used to address the effects of the hydropower system on fish and wildlife (NWPPC 1987). Resident game fish populations have been established in Franklin D. Roosevelt Lake, the reservoir behind Grand Coulee Dam, since the extirpation of anadromous fish species. The resident game fish populations are now responsible for attracting a large percentage of the recreational visits to the region. An increase in popularity has placed Lake Roosevelt fifth amongst the most visited State and Federal parks in Washington. Increased use of the reservoir prompted amplified efforts to enhance the Native American subsistence fishery and the resident sport fishery in 1984 with hatchery supplementation of rainbow trout (O. mykiss) and kokanee salmon (O. nerka). This was followed by the formation of the Spokane Tribal Lake Roosevelt Monitoring Project (LRMP) in 1988 and later by formation of the Lake Roosevelt Data Collection Project in 1991. The Lake Roosevelt Data Collection Project began in July 1991 as part of the BPA, Bureau of Reclamation, and U.S. Army Corps of Engineers System Operation Review process. This process sought to develop an operational scenario for the federal Columbia River hydropower system to maximize the in-reservoir fisheries with minimal impacts to all other stakeholders in the management of the Columbia River. The Lake Roosevelt Monitoring/Data Collection Program (LRMP) is the result of a merger between the Lake Roosevelt Monitoring Program (BPA No. 8806300) and the Lake Roosevelt Data Collection Project (BPA No. 9404300). These projects were merged in 1996 forming the Lake Roosevelt Monitoring Program (LRMP), which continues the work historically completed under the separate projects. The LRMP has two main goals. The first is to develop a biological model for Lake Roosevelt that will predict in-reservoir biological responses to a range of water management operational scenarios, and to develop fisheries and reservoir management strategies accordingly. The model will allow identification of lake operations that minimize impacts on lake biota while addressing the needs of other interests (e.g. flood control, hydropower generation, irrigation, and downstream resident and anadromous fisheries). Major components of the model will include: (1) quantification of entrainment and other impacts to phytoplankton, zooplankton and fish caused by reservoir drawdowns and low water retention times; (2) quantification

  10. phys. stat. sol. (b) 212, R1 (1999) Subject classification: 78.30.Fs; S7.14; S8.11

    E-Print Network [OSTI]

    Nabben, Reinhard

    or infrared and Raman-inactive (so-called silent) vibrational modes (for a review see, e.g., Ref. [1 the softening of the E1(LO) mode normally observed at 742 cm±±1 by a heating up of the sample due that heating up of the sample due to imperfectness and intrinsic defects can not be excluded. CdS exhibits

  11. Contamination sources of PCDD/Fs, dioxin-like PCBs, PAHs and trace metals in sediments of high and low impacted transboundary rivers (Belgium-France).

    E-Print Network [OSTI]

    Boyer, Edmond

    such as coal mining, electricity production, steel and non-ferrous metals' smelters, textile manufacturing, in some cases the contribution of long range pollutant transport should be taken into account. Direct but pollutants associated with contaminated soils alongside the river border can also accumulate in the same

  12. March 15, 2000 / Vol. 25, No. 6 / OPTICS LETTERS 423 Generation of 90-fs pulses from a mode-locked diode-pumped

    E-Print Network [OSTI]

    Boyer, Edmond

    with a crystalline host. This laser is mode locked with a high-finesse semiconductor saturable-absorber mirror with the capability to bridge the gap in terms of pulse dura- tion, on the one hand, and emission cross sections

  13. Modeling the interplay of fO2 and fS2 along the FeS-silicate melt equilibrium Roberto Moretti a,

    E-Print Network [OSTI]

    Long, Bernard

    , , Don R. Baker b,c a Istituto Nazionale di Geofisica e Vulcanologia, sezione Osservatorio Vesuviano, Via Geofisica e Vulcanologia, sezione Roma 1, via di Vigna Murata 605, 00143 Roma, Italy a b s t r a c ta r t i

  14. Ecosystem Stewardship as a Framework for Conservation in a Directionally Changing World T.R. Seastedt, K.N. Suding and F.S. Chapin III

    E-Print Network [OSTI]

    Ickert-Bond, Steffi

    1 Ecosystem Stewardship as a Framework for Conservation in a Directionally Changing World T (Raudsepp-Hearne et al. 2010). All ecosystems on earth show the imprint of human actions. The resulting provided in this book (Chapter 6), hybrid and novel ecosystems dominate Earth's biotically active layer

  15. AAAI Fall Symposium on Human-Robot Interaction, AAAI Technical Report FS-02-03, pp. 111 119, November 2002. A Taxonomy for Human-Robot Interaction

    E-Print Network [OSTI]

    Yanco, Holly A.

    , November 2002. A Taxonomy for Human-Robot Interaction Holly A. Yanco and Jill L. Drury Computer Science of a taxonomy for human-robot interaction. By drawing from multiple research fields, a more complete taxonomy is attained. Taxonomy categories include team composition (ratio of people to robots, types of robots), amount

  16. Assimilation of SeaWiFS chlorophyll data into a 3D-coupled physicalbiogeochemical model applied to a freshwater-influenced

    E-Print Network [OSTI]

    Fontana, Clément

    2009 Keywords: Data assimilation Kalman filter Remote sensing Eutrophication a b s t r a c t In order to predict eutrophication events in coastal areas we tested an assimilation scheme based on sequential data to the Rhone River delta. This system is subjected to episodic eutrophication caused by certain hydrodynamic

  17. 4/18/2014 WHO | Millennium Development Goals (MDGs) http://www.who.int/mediacentre/factsheets/fs290/en/ 1/5

    E-Print Network [OSTI]

    Tipple, Brett

    with deaths among HIV-negative tuberculosis cases. In 2010, the world met the United Nations Millennium an estimated rate of 90 deaths per 1000 live births to 48. The global rate of decline has also accelerated, the number of deaths of children under five years of age fell from 12.6 million in 1990 to 6.6 million

  18. 7. Top-down control over the motor cortex Rogier B. Mars, Franz-Xaver Neubert, and Matthew F.S. Rushworth

    E-Print Network [OSTI]

    Mars, Rogier Bertrand

    7. Top-down control over the motor cortex Rogier B. Mars, Franz-Xaver Neubert, and Matthew F selection, top-down control is particularly needed during situations of response conflict, where. In this chapter, we discuss recent advances in the study of top-down control over motor cortex during action

  19. In Anderson, M. (ed) AAAI Technical Report on the 1997 Fall Symposium: Reasoning with Diagrammatic Representations II. (Technical Report FS-97-02) pp.85-93, 1997.

    E-Print Network [OSTI]

    Cheng, Peter

    Solving and Discovery with Law Encoding Diagrams Peter C-H. Cheng. ESRC Centre for Research in Development.cheng@nottingham.ac.uk Abstract The representational components for a cognitive theory of Law Encoding Diagrams, LEDs. Introduction Law Encoding Diagrams are an interesting class of diagrammatic representations, the study of which

  20. U.S. Department of the Interior USGS Fact Sheet FS-006-03 U.S. Geological Survey August 2003

    E-Print Network [OSTI]

    , and suitable containers (centrifuge tubes) of size appropriate to process and hold sample volumes consistent using a 10- mL disposable syringe and stored in 2-mL centrifuge tubes. If a different analyticalL centrifuge tube. Attach an IC-H cartridge to the syringe/ filter assembly. At no more than two drops per

  1. EIS-0005-FS: Bonneville Power Administration Proposed FY 1979 Program, Facility Location on Supplement, Southwest Oregon Area Service, Buckley-Summer Lake 500 kV Line, Supplemental

    Broader source: Energy.gov [DOE]

    This Bonneville Power Administration document assesses the environmental impacts of constructing transmission facilities, which will coordinate with the Midpoint-Malin 500-kV line to be constructed by the Pacific Power and Light (PP&L) Company. The proposed action includes the construction of the 1.56-mile Buckley-Summer Lake 500-kV transmission line; the proposed Buckley Substation near Maupin, Oregon; and the proposed Summer Lake Substation near Silver Lake, Oregon.

  2. Performance Audit of the Department of Energy's Improper Payment Reporting in the Fiscal Year 2011 Agency Financial Report, OAS-FS-12-07

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO2:Introduction toManagementOPAM5Parabolic Trough ParabolicPerformance Audit of the

  3. DOE/EIS-0203-SA-07 DOE/EA-1148-SA-01 DOE/EIS-0250F-S-1-SA-02

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItem NotEnergy,ARMFormsGas SeparationsRelevantDOE Progress Review ofDOE-ORP

  4. Trhu, A.M., Bohrmann, G., Torres, M.E., and Colwell, F.S. (Eds.) Proceedings of the Ocean Drilling Program, Scientific Results Volume 204

    E-Print Network [OSTI]

    Guerin, Gilles

    Program, Scientific Results Volume 204 SONIC VELOCITIES IN AN ACTIVE GAS HYDRATE SYSTEM, HYDRATE RIDGE1 the sonic velocities of the sediments in an active gas hydrate sys- tem. In addition, vertical seismic operation. We use a model for the cementation of grains by hydrate formation to estimate gas hydrate

  5. Work Plan: Work Plan for the Remedial Investigation/Feasibility Study - Environmental Assessment (RI/FS-EA) for the Quarry Residuals Operable Unit at the Weldon Spring Site.

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA group currentBradleyTableSelling7 AugustAFRICAN3uj:'I,\ W C -hSinceSite

  6. Audit Report - Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2010 Balance Sheet Audit, OAS-FS-13-09

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed off Energy.gov. Are you0 ARRA NewslettersPartnership1/08 Attendance List7-26 AuditLetter

  7. Audit Report - Management Letter on the Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 2012, OAS-FS-13-08

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed off Energy.gov. Are you0 ARRA NewslettersPartnership1/08 Attendance List7-26 AuditLetterAudit of the

  8. DOE/EIS-0203-SA-07 DOE/EA-1148-SA-01 DOE/EIS-0250F-S-1-SA-02

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny:Revised Finding of No Significant6-2002DOE/EA-1313 Rev. 0Program132-F

  9. Report on Matters Identified at Strategic Petroleum Reserve During Audit of Statement of Financial Position, CR-FS-96-03

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn April 23, 2014, an OHASeptemberAssessments | Department ofSouthernof theServiceJunean

  10. Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2010 Balance Sheet Audit, OAS-FS-13-11

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed off Energy.gov. Are you0andEnergyGlobal Nuclearof aDepartment oftheAL 2010-5Department of

  11. Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2009 Balance Sheet Audit, OAS-FS-12-08

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny:Revised Finding of No53197E T A * S H I E L D * A L ALGALImplementation

  12. Management Letter on the Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2009 Balance Sheet Audit, OAS-FS-12-09

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(FactDepartment ofLetterEconomyDr.Energy University of California'sthe

  13. September 24-25, 2003 HAPL meeting, UW 1

    E-Print Network [OSTI]

    Raffray, A. René

    for Chamber System Studies · Structural material: FS or ODS FS · Armor Material: W · Develop FW operation · Choose self-cooled lithium blanket with ODS FS and W - Maximum temperature limits (from last first wall "battle plan" conference call) · Li/FS interface temperature ODS FS maximum

  14. DEVELOPMENT OF DATABASE ON FECAL SLUDGE COLLECTION, TREATMENT AND DISPOSAL IN THACHIN,

    E-Print Network [OSTI]

    Richner, Heinz

    i DEVELOPMENT OF DATABASE ON FECAL SLUDGE COLLECTION, TREATMENT AND DISPOSAL IN THACHIN, CHAOPRAYA Sludge (FS) management and lacking of data on FS collection, treatment and disposal. Nevertheless, FS

  15. November 8-9, 2005 Blanket Design for Large Chamber

    E-Print Network [OSTI]

    Raffray, A. René

    - Max. FS/Li interface temp. ODS Advanced Case Advanced Case RAFS RAFS ODS FS ODS FS Chamber radius, Rchamb (m) 10.5 10.5 11 11 Rep rate 5

  16. Appropriate Acquisition Strategy PMLL Identifier: PMLL-2011-NNSS...

    Energy Savers [EERE]

    both fire stations in one RFP (with FS 1 as an option), the contractors would front load their proposals for FS 2 and also significantly increase the bid price for FS 1 to...

  17. November 4-5, 2004/ARR ARIES-CS Power Core Options for

    E-Print Network [OSTI]

    Raffray, A. René

    None Be(pebble bed) Coolant Flibe Pb-17Li He + self He + self He Structure ODS FS (nano- sized) SiCf/SiC RAFS & ODS FS (+SiC insert if required) RAFS & ODS FS RAFS & ODS FS Struct. Tmax (°C) 700 1000 550 (RAFS) 700 (ODS FS) 550 550 (RAFS) 700 (ODS FS) Breeder Tmax (°C) 700 1100 800 700 950 Breeder Tmin (°C

  18. Community-Based Memorials to September 11, 2001: Environmental Stewardship

    E-Print Network [OSTI]

    -mail: esvendsen@fs.fed.us; lindsaycarnpbell@fs.fed.us K.G. Tidball and M.E. Krasny (eds.), Greening in the Red

  19. /7 soF'/t,,,,n,re D toPm NT". Using a Co nf=guration Management Tool to CoordInate

    E-Print Network [OSTI]

    Grinter, Rebecca Elizabeth

    for coordination they provide, and their role in supporting a model of work. KEYWORDS: configuration management (CM of coordinating group work. This particular technology, a configuration management (CM) tool, incorporates begins with a description of configuration management, and how it involves coordinating the work

  20. Form factors of the $D \\to ?$ and $D \\to K$ semileptonic decays with $N_f = 2$ twisted mass lattice QCD

    E-Print Network [OSTI]

    S. Di Vita; B. Haas; V. Lubicz; F. Mescia; S. Simula; C. Tarantino; for the ETM Collaboration

    2011-04-05T23:59:59.000Z

    We present lattice results for the vector and scalar form factors of the semileptonic decays D -> \\pi \\ell \

  1. Regulation of cytochrome P450 3A4 gene expression through modulating pregnane X receptor transcriptional activity by NF-? aryl hydrocarbon receptor and xenobiotics 

    E-Print Network [OSTI]

    Gu, Xinsheng

    2009-05-15T23:59:59.000Z

    Cytochrome P450 3A4 (CYP3A4) is a key enzyme responsible for the metabolism of drugs and endogenous compounds in human liver and intestine. CYP3A4 gene expression is mainly regulated by Pregnane X receptor (PXR) which is a ligand-dependent nuclear...

  2. Distinct NF-kB activation pathways engaged by T-cell receptor and co-receptor CD28 on T-cells

    E-Print Network [OSTI]

    Thaker, Youg Raj; Rudd, Christopher E

    2015-03-02T23:59:59.000Z

    at the pro-T3 stage [16]. In addition to this, Jurkat T-cell mutant lines lacking either SLP-76 or LAT expression showed a vital requirement of both molecules in mediating TCR-induced PLC?1 phosphorylation, extracellular signal-regulated kinase (ERK...

  3. DU145 human prostate cancer cells express functional Receptor Activator of NF-B: New insights in the prostate cancer bone metastasis process.

    E-Print Network [OSTI]

    Boyer, Edmond

    in the prostate cancer bone metastasis process. Mori K.1, 2, * , Le Goff B. 1, 2 , Charrier C. 1, 2 , Battaglia S cells, thus facilitating prostate cancer metastasis development in bone. We confirm that RANKL is a factor that facilitates metastasis to bone by acting as an activator of both osteoclasts and RANK

  4. Regulation of cytochrome P450 3A4 gene expression through modulating pregnane X receptor transcriptional activity by NF-? aryl hydrocarbon receptor and xenobiotics

    E-Print Network [OSTI]

    Gu, Xinsheng

    2009-05-15T23:59:59.000Z

    by biotransformation alters its biological effects, not only its pharmacokinetic behavior. In the case of pharmacology, some drugs must undergo biotransformation to exert their pharmacodynamic effect. In the case of toxicology, many xenobiotics must undergo...

  5. port reduces NF to 3.76 dB, which is in good agreement with the noise figure predicted without circuit losses at 5.8 GHz.

    E-Print Network [OSTI]

    Jerby, Eli

    monolithic low noise amplifier for wireless applications at 5 GHz, 1996 IEEE MMMICs Dig, pp 81­84. 9. I and procedures utilized to design an amplifier that can simultaneously provide high-gain, low-power consumption amplifier for low cost 1.5­8 GHz commercial applications, 1993 IEEE MMICS Dig, pp 13­16. 6. K.R. Gioffi

  6. TWIST1 associates with NF-kappaB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 production

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    subunit RELA via carboxyl-terminal WR domain to promote cellthrough the TWIST1 carboxy-terminal WR (Trp-Arg) domainis dependent on the C- terminal WR domain, through which

  7. Stimulation of Fas (CD95) induces production of pro-inflammatory mediators through ERK/JNK-dependent activation of NF-jB in THP-1 cells

    E-Print Network [OSTI]

    Lee, Won-Ha

    Stimulation of Fas (CD95) induces production of pro-inflammatory mediators through ERK line THP-1 (which expresses both Fas and FasL) was stimulated through treatment with agonistic anti in macrophage function, the human macrophage-like cell line THP-1 was analyzed after treatment with agonistic

  8. Three-gluon running coupling from lattice QCD at $N_f=2+1+1$: a consistency check of the OPE approach

    E-Print Network [OSTI]

    Ph. Boucaud; M. Brinet; F. De Soto; V. Morenas; O. Pène; K. Petrov; J. Rodríguez-Quintero

    2014-01-31T23:59:59.000Z

    We present a lattice calculation of the renormalized running coupling constant in symmetric (MOM) and asymmetric ($\\widetilde{\\rm MOM}$) momentum substraction schemes including $u$, $d$, $s$ and $c$ quarks in the sea. An Operator Product Expansion dominated by the dimension-two $\\langle A^2\\rangle$ condensate is used to fit the running of the coupling. We argue that the agreement in the predicted $\\langle A^2\\rangle$ condensate for both schemes is a strong support for the validity of the OPE approach and the effect of this non-gauge invariant condensate over the running of the strong coupling.

  9. 15-Deoxy-?{sup 12,14}-prostaglandin J{sub 2} inhibits IL-13 production in T cells via an NF-?B-dependent mechanism

    SciTech Connect (OSTI)

    Doyle, Marie-Christine; Tremblay, Sarah [Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke (QC), Canada J1K 2R1 (Canada)] [Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke (QC), Canada J1K 2R1 (Canada); Dumais, Nancy, E-mail: nancy.dumais@usherbrooke.ca [Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke (QC), Canada J1K 2R1 (Canada)] [Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke (QC), Canada J1K 2R1 (Canada)

    2013-02-15T23:59:59.000Z

    Highlights: ? 15d-PGJ{sub 2} decreased IL-13 mRNA transcription and secretion in activated T cells. ? IL-13 inhibition by 15d-PGJ{sub 2} is independent of PPAR-?. ? The nuclear factor-?B mediates the 15d-PGJ{sub 2}-dependent down regulation of IL-13. -- Abstract: Interleukin (IL)-13 is a cytokine produced by activated CD4{sup +} T cells that plays a critical role in promoting allergic responses and tumor cell growth. The 15-deoxy-?{sup 12,14}-prostaglandin J{sub 2} (15d-PGJ{sub 2}) is a natural ligand for the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-?), a known regulator of anti-inflammatory activities. We determined the effects of 15d-PGJ{sub 2} on IL-13 expression in the Jurkat E6.1 T-cell line and in peripheral blood mononuclear cells. Semi-quantitative reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay revealed that treatment of activated T cells with 15d-PGJ{sub 2} significantly decreased IL-13 mRNA transcription and secretion, respectively. This inhibition by 15d-PGJ{sub 2} was independent of PPAR-? since treatment with GW9662, an irreversible antagonist of the nuclear receptor, produced no effect. Our data also revealed the involvement of nuclear factor-?B in mediating 15d-PGJ{sub 2}-dependent down regulation of IL-13 expression. Collectively, these results demonstrate the potential of 15d-PGJ{sub 2} in attenuating expression and production of IL-13 in activated T cells.

  10. D O M A I NF A L L 2 0 0 4 55555 How a Top Secret Satellite and Fast-Thinking

    E-Print Network [OSTI]

    Weathermen Saved the Apollo 11 Astronauts from Disaster I t was one of those turning points in history where his "one small step for man," and the Apollo 11 Moon landers were speed ing back towards Earth-thinking weathermen -- Navy CAPT Willard "Sam" Houston and Air Force Maj. Hank Brandli. Saving Apollo 11Saving Apollo

  11. Deregulation of the phosphatidylinositol-3 kinase signaling cascade is associated with neurodegeneration in Npc1-/- mouse brain.

    E-Print Network [OSTI]

    Bi, Xiaoning; Liu, Jihua; Yao, Yueqin; Baudry, Michel; Lynch, Gary

    2005-01-01T23:59:59.000Z

    Inherited Diseases Deregulation of the Phosphatidylinositol-tion, and for NF- ? B deregulation; moreover, these changes3 ? Is Associated with Deregulation of NF- ? B Accumulating

  12. } {1538505 El5~ETL"9u6h6pl461 CSFb8&5fEe405 } 3388570 :k6L8)$5$$$?$^;T2Bg5WJ]255 Fs==0l@$5*5!9=Eo

    E-Print Network [OSTI]

    Tokyo, University of

    %s $r7+$jJV$7!$1 %U%l!¡%`Kh$K%9%-%c%s7k2L$N%^%C%A%s%0$r9T$C $F7WB,¡VN¿$N5sF0$r;;=P$9$kJK![8] $,$"$k

  13. FS-6700-7 (2/98) NOTE: Any yellow text shading or red text annotations have been added by ORNL Subject Matter Experts (SMEs). The annotations have been made

    E-Print Network [OSTI]

    -Hazardous road conditions -Falls, twisted or sprained joints, broken bones -Branch and other eye or head and local conditions -Carry insect repellent, sun block, ivy block, antihistamine/allergy medication

  14. 23F.S. Chapin, III et al., Principles of Terrestrial Ecosystem Ecology, DOI 10.1007/978-1-4419-9504-9_2, Springer Science+Business Media, LLC 2011

    E-Print Network [OSTI]

    Hansen, Andrew J.

    ;24 2 Earth's Climate System temperature. Because it is hot (6,000°C), the sun emits most energy as high distribution of terrestrial biomes. This chapter provides a general back- ground on the functioning exerts a key control over the function- ing of Earth's ecosystems. Temperature and water availability

  15. FS-6700-7 (2/98) NOTE: Any yellow text shading or red text annotations have been added by ORNL Subject Matter Experts (SMEs). The annotations have been made in order to document (1)

    E-Print Network [OSTI]

    . Avoiding / Treating Bee Stings Allergic reactions, painful stings A. Be alert to hives in brush or in hollow logs. Watch for insects travelling in and out of one location. B. If you or anyone you are working

  16. //FS/ELS/PAGINATION/ELSEVIER AMS/STPS/3B2/CH07-N2955.3D 75 [7592/18] 28.10.2006 10:40AM 7. Eustatic Sea Level During Past Interglacials

    E-Print Network [OSTI]

    Siddall, Mark

    , The Australian National University, Canberra 0200, Australia 3 Institute for Isotope Geology and Mineral Resources, Department of Earth Sciences, ETH, Zurich, Switzerland ABSTRACT Eustatic sea-level variation is the primary index of global ice volume over glacial cycles. Here, we review recent studies of eustatic sea

  17. -TU3.fs S$Ee{rsrRY SBFaR?}dEtSr tne sfflclal" records af Tufte 6o1J.ege for the year 18bS

    E-Print Network [OSTI]

    Kounaves, Samuel P.

    &themtics and piiysieB" 'fbe recorda aleo ehow th*rt he held thie Bositlon until 186S wiren he was relreved of two c

  18. Comments on Draft Feasibility Study (FS) for Remedial Action for the Quarry Residuals Operable Unit (QROU) at the Weldon Spring Site, and Draft Proposed Plan (PP) for the QROU at Weldon Spring. QY-500-501-1.04.

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA group currentBradleyTableSelling Corp -KWatertowni5W 95.5x-L* d! CT.J>?j 1.29

  19. Draft Proposed Plan (PP) for Remedial Action at Quarry Residuals Operable Unit, and Draft Feasibility Study (FS) for Remedial Action for the Quarry Residuals Operable Unit at Weldon Spring Site, June 1997. QY-500-501-1.05.

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA group currentBradleyTableSelling CorpNew 1325.8.Enaineer District andP.Dr.Wm. E.

  20. ON THE FLUX OF PSEUDO-ANOSOV HOMEOMORPHISMS VINCENT COLIN, KO HONDA, AND FRANC OIS LAUDENBACH

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    ON THE FLUX OF PSEUDO-ANOSOV HOMEOMORPHISMS VINCENT COLIN, KO HONDA, AND FRANC¸ OIS LAUDENBACH HONDA, AND FRANC¸ OIS LAUDENBACH h(Fs , µs ) = (Fs , 1 µs ) and h(Fu , µu ) = (Fu , µu

  1. Slide 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 n (%) - Eamonn Murray & Stephen Fahy, University College, Cork, Ireland Murray et al. PRB 72, 060301 (R) 2005. 467 fs Nature Nature 422, 287 (2003) 422, 287 (2003) 200 fs ...

  2. Low-Dimensional Maps Encoding Dynamics in Entorhinal Cortex and Hippocampus

    E-Print Network [OSTI]

    Rotstein, Horacio G.

    FS interneurons. We use spike time response curve methods (STRC), expanding that technique to three not robustly synchronize unless there are other kinds of interneurons in the net- work, e.g., fast-spiking (FS

  3. Calendar Year 1997 | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    May 1, 1997 Audit Report: CR-FS-97-02 Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 1996 April 24, 1997 Audit Report: WR-FS-97-04 Report on...

  4. A MULTI-ELEMENT SILICON DETECTOR FOR X-RAY FLUX MEASUREMENTS

    E-Print Network [OSTI]

    Thompson, A.C.

    2010-01-01T23:59:59.000Z

    P, Wilson S, Rubenstein E, Thompson A C and Walton 0 T, IEEEFLUX MEASUREMENTS A.C. Thompson, F.S. Goulding, H.A. Sommer,MEASUREMENTS LBL-12746 A. C. Thompson, F.S. Goulding» H» A.

  5. Two-photon Photo-emission of Ultrathin Film PTCDA Morphologies on Ag(111)

    E-Print Network [OSTI]

    Yang, Aram

    2008-01-01T23:59:59.000Z

    to generate tunable ultrafast pulses of ?100 fs durationIn short, a pulse from a commercial ultrafast oscillator is

  6. Terahertz Imaging and Remote Sensing Design for Applications in Medical Imaging

    E-Print Network [OSTI]

    Sung, Shijun

    2013-01-01T23:59:59.000Z

    A similar type of ultrafast laser (pulse duration: 230 fs,generates broadband pulses in the ultrafast substrate

  7. Modal and Temporal Logics Colin Stirling

    E-Print Network [OSTI]

    Stirling, Colin

    : S S f(S) f(S ) f is essentially modal (using - and [-]). cps wssa 03 today #12;3 Summary: Fixed points [-]A( U )) Syntactically: property X such that 1. X ( - X) 2. X ( - tt [-]X) cps wssa 03 today.r.t ) then f 1. has a least fixed point, {S : f(S) S} 2. has a greatest fixed point, {S : S f(S)} cps wssa 03

  8. BENEFITS OF RADIAL BUILD MINIMIZATION AND REQUIREMENTS IMPOSED ON ARIES COMPACT STELLARATOR DESIGN

    E-Print Network [OSTI]

    field at the coil. During the first phase of the study, several blanket/shield systems have been considered employing advanced ferritic steel (FS) structure (such as IEA MF82H) and SiC/SiC composites-based systems (self-cooled Flibe/FS/Be and LiPb/SiC, and dual-cooled LiPb/FS/He and Li/FS/He). The newly

  9. Integrated Circuit Blocks for High Performance Baseband and RF Analog-to-Digital Converters

    E-Print Network [OSTI]

    Chen, Hongbo

    2012-02-14T23:59:59.000Z

    -stage pipeline ADC ........................................................ 11 Fig. 2. 2. Proposed reconfigurable technique: (a) full speed mode (Fs) (b) Fs/2 speed mode (c) Fs/4 speed mode.... sampling rates and Comparison with state-of-the-art reconfigurable 10bit pipeline ADCs ....................................................................................... 24 Fig. 3. 1. A oversampling system without noise shaping...

  10. Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NF{kappa}B and AhR and EGFR-ERK pathway

    SciTech Connect (OSTI)

    Potapovich, Alla I. [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy); Biology Department, Belarus State University, Skorina Prosp. 10, Minsk 220050 (Belarus); Lulli, Daniela; Fidanza, Paolo [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy); Kostyuk, Vladimir A. [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy); Biology Department, Belarus State University, Skorina Prosp. 10, Minsk 220050 (Belarus); De Luca, Chiara; Pastore, Saveria [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy); Korkina, Liudmila G., E-mail: l.korkina@idi.it [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy)

    2011-09-01T23:59:59.000Z

    Molecular mechanisms underlying modulation of inflammatory responses in primary human keratinocytes by plant polyphenols (PPs), namely the glycosylated phenylpropanoid verbascoside, the stilbenoid resveratrol and its glycoside polydatin, and the flavonoid quercetin and its glycoside rutin were evaluated. As non-lethal stimuli, the prototypic ligand for epidermal growth factor receptor (EGFR) transforming growth factor alpha (TGFalpha), the combination of tumor necrosis factor (TNFalpha) and interferon (IFNgamma) (T/I), UVA + UVB irradiation, and bacterial lipopolysaccharide (LPS) were used. We demonstrated differential modulation of inflammatory responses in keratinocytes at signal transduction, gene transcription, and protein synthesis levels as a function of PP chemical structure, the pro-inflammatory trigger used, and PP interaction with intracellular detoxifying systems. The PPs remarkably inhibited constitutive, LPS- and T/I-induced but not TGFalpha-induced ERK phosphorylation. They also suppressed NFkappaB activation by LPS and T/I. Verbascoside and quercetin invariably impaired EGFR phosphorylation and UV-associated aryl hydrocarbon receptor (AhR)-mediated signaling, while rutin, polydatin and resveratrol did not affect EGFR phosphorylation and further activated AhR machinery in UV-exposed keratinocytes. In general, PPs down-regulated gene expression of pro-inflammatory cytokines/enzymes, except significant up-regulation of IL-8 observed under stimulation with TGFalpha. Both spontaneous and T/I-induced release of IL-8 and IP-10 was suppressed, although 50 {mu}M resveratrol and polydatin up-regulated IL-8. At this concentration, resveratrol activated both gene expression and de novo synthesis of IL-8 and AhR-mediated mechanisms were involved. We conclude that PPs differentially modulate the inflammatory response of human keratinocytes through distinct signal transduction pathways, including AhR and EGFR. - Graphical abstract: Display Omitted Highlights: > Effects of plant polyphenols on inflammatory responses in human keratinocytes. > Inflammatory stimuli used: TGFalpha, TNFalpha+IFNgamma, UVA+UVB, and LPS. > Inflammatory pathways connected with NFB, ERK1/2, EGFR, and AhR were investigated. > Plant polyphenols, flavonoids, stilbenoids, and phenylpropanoids, were studied. > Modulation of inflammation depends on phenolic core structure and glycosylation.

  11. High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53 - NF-kappaB - complex-dependent gene expression in human heart failure

    E-Print Network [OSTI]

    Choy, Mun-Kit; Movassagh, Mehregan; Siggens, Lee; Vujic, Ana; Goddard, Martin; Sanchez, Ana; Perkins, Neil; Figg, Nichola; Bennett, Martin; Carroll, Jason; Foo, Roger S-Y

    2010-06-14T23:59:59.000Z

    00.5 1 1.5 2 miR-15b miR-21 miR-125b -Dox +Dox Additional file 2 (Choy, et al) 40 30 20 1 0 mir-15b mir-21 mir-125b Dox control m iR N A a bu nd an ce [a rb ita ry u ni ts ] 0 0.02 0.04 0.06 0.08 1 2 normoxia hypoxia 30 0 6 90 CF m iR -2 1 ab un... da nc e [a rb ita ry u ni ts ] Hypoxia - + WB: p53 WB: SF2 DFX - -+ + Nuc Cyt WB: p53 WB: SF2 WB: RhoGDI A B C Dox - + WB: p53 WB: SF2 * * ...

  12. Supplementary Fig. 1. Inhibition of TLR2-induced NF-B activation by TirS is comparable to inhibition mediated by DN-hMyD88 or addition of a TLR2 antagonist SSL3. Untreated control

    E-Print Network [OSTI]

    Nizet, Victor

    to inhibition mediated by DN-hMyD88 or addition of a TLR2 antagonist SSL3. Untreated control cells were

  13. antibodies targeting cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of an NF-B responsive element (pNF-B- Luc) encapsulated in a PRb peptide functionalized stealth targeted systems. In addition, we constructed a novel cancer therapeutic plasmid...

  14. akt phosphorylation sites: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ser-142 (14). Ser-129 is believed to be a substrate for glycogen synthase kinase 3 Brownfield, Mark S. 36 Mass spectrometric analysis of bovine neurofilament proteins NF-L, NF-M,...

  15. Production de code assembleur 7.1 Du code intermdiaire l'assembleur abstrait : la slection d'instructions . . . . 1

    E-Print Network [OSTI]

    Balat, Vincent - Laboratoire Preuves, Programmes et Systèmes, Université Paris 7

    (** Arithmetical operation on registers *) | OPI of binop * temp * temp * int (** Same , with immediate 2nd operand ,s2) -> let s1 = fs s1 in let s2 = fs s2 in let d = fd d in OP (o,d,s1 ,s2) | OPI (o,d,s,i) -> let s = fs s in let d = fd d in OPI (o,d,s,i) | BR (r,s1 ,s2,l) -> let s1 = fs s1 in let s2 = fs s2 in BR (r

  16. Final state effects in photoemission studies of Fermi surfaces This article has been downloaded from IOPscience. Please scroll down to see the full text article.

    E-Print Network [OSTI]

    surface (FS). Photoemission can be used to probe the FS of materials in 1, 2, and 3D, in a broad range both energy and k broadening, which can give rise to shadow or ghost FS contours, scattering and final-8984/07/355001+14$30.00 © 2007 IOP Publishing Ltd Printed in the UK 1 #12;J. Phys.: Condens. Matter 19 (2007) 355001 R L Kurtz et

  17. CELLFS: TAKING THE "DMA" OUT OF CELL PROGRAMMING

    SciTech Connect (OSTI)

    IONKOV, LATCHESAR A. [Los Alamos National Laboratory; MIRTCHOVSKI, ANDREY A. [Los Alamos National Laboratory; NYRHINEN, AKI M. [Los Alamos National Laboratory

    2007-01-09T23:59:59.000Z

    In this paper we present a new programming model for the Cell BE architecture of scalar multiprocessors. They call this programming model CellFS. CellFS aims at simplifying the task of managing I/O between the local store of the processing units and main memory. The CellFS support library provides the means for transferring data via simple file I/O operations between the PPU and the SPU.

  18. Photoemission Electron Microscopy of a Plasmonic Silver Nanoparticle...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    near-fields resulting from femtosecond (fs) laser excitation of localized surface plasmon oscillations in the triangular core-shell structure. We demonstrate that the...

  19. Materials Applications of Photoelectron Emission Microscopy....

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    a variety of photoexcitation sources including synchrotron emission, femtosecond laser pulses and conventional UV lamp emission. Each source has advantages, for example, fs...

  20. Design Studies for a VUV--Soft X-ray Free-Electron Laser Array

    E-Print Network [OSTI]

    Corlett, J.

    2010-01-01T23:59:59.000Z

    bunch arrival time in the LCLS, and another system that willFERMI@Elettra and 100 fs for LCLS, both requiring about 200-

  1. Analysis and corrective measures for forced commutated cycloconverters(FCC'S) under unbalance

    E-Print Network [OSTI]

    Wang, Xucheng

    1991-01-01T23:59:59.000Z

    improved and bettered. In view of Three-phase Input Three-phage Output hga J (a) 0 dp p opuuped t A B t A S t A (b) Figure l. (a) Simplified Poiver Circuit ot' VCC (b) iVCC Output Voltage AVaveforui these trends it is now possible to successfully... representative of input frequency (normally 60 Hz), and the switching transfer function to be, where Ft Fz Fs [T(&p, t)' , = Fs Ft Fz Fz Fs Ft (2. '? ) [Ft Fz Fs] = A[cos(u&, t) cos(w, t ? 120') cos(u&, t + 120')l ('?. 3) and w, is a representive...

  2. advance lab-on-a-chip devices: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: University, Durham, NC 27708, USA wlh,fs,krish@ee.duke.edu ABSTRACT Microfluidics-based biochips, also Keywords Pin-constrained design, virtual partitioning,...

  3. ASTROBIOLOGY Volume 6, Number 5, 2006

    E-Print Network [OSTI]

    Stewart, Frank

    , Boulder (SnR; 1, 2, and 2A) Frank J. Stewart, Harvard University (FS; 3, 3A­C, and 6B) Kaspar von Braun

  4. albeni falls wildlife: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    JAMES A. MARTIN, Department of Wildlife, Fisheries 5 Wildlife Landscape Ecology -Syllabus FS599 Fall Term 2010 Geosciences Websites Summary: 1 Wildlife Landscape Ecology -...

  5. One- and two-dimensional infrared spectroscopic studies of solution-phase homogeneous catalysis and spin-forbidden reactions

    E-Print Network [OSTI]

    Sawyer, Karma Rae

    2010-01-01T23:59:59.000Z

    Tsunami 80 MHz, 650 mW, 80 fs, 800 nm (FWHM = 13nm) Nd:YLF nanosecond pump laser SpectraPhysics Evolution-

  6. The Linux Pseudorandom Number Generator Revisited Patrick Lacharme

    E-Print Network [OSTI]

    . for the analysis of Yarrow [KSF99] and by Fergusson and Schneier for the analysis of Fortuna [FS03, Ch. 10]. Other

  7. Radiolysis of Amino Acids: A Study Using Raman Spectroscopy, Ultraviolet-Visible Spectrophotometry and Electrospray Ionization Mass Spectrometry

    E-Print Network [OSTI]

    Lou, Jijie

    2014-12-17T23:59:59.000Z

    s s s s s sss s S - y iy s s s s s ys s - f y yy yf fs f s y ssfs ss is s #2;s sss ss s-s s s sfs s fy s-s s s ss s sfs s fy s fs... s s s ................................ 5 4.4.4 s s - s s f s s s y y s s sys s ............. 6 4.4.s s fs s s ss s fs s s sys s s s ......... 8 4.4.4 s s s s is s #2;s sss ss...

  8. assessing cumulative impact: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: CEC-500-2010-FS-016 Cumulative Biological Impacts Framework for Solar Energy Projects demand with renewable energy by the year 2020. Large-scale solar developments...

  9. Energy Department Finalizes $646 Million Loan Guarantee to Support...

    Office of Environmental Management (EM)

    region." The Antelope Valley Solar Ranch 1 Project will employ First Solar's FS Series 3 PV Module and will feature innovative inverters with voltage regulation and monitoring...

  10. TU Dortmund | Fakultt Raumplanung Dekanat Studien-und Projektzentrum (SPZ)

    E-Print Network [OSTI]

    Kierfeld, Jan

    Fachschaft Raumplanung E-Mail: fs.rp@tu-dortmund.de www.fsrp.de, Tel. (0231) 755-2383. Stand 06.08.2014 2 / 3

  11. TU Dortmund Fakultt Raumplanung, Dekanat | August-Schmidt-Str. 10 | 44227 Dortmund

    E-Print Network [OSTI]

    Kierfeld, Jan

    -europe.rp@tu-dortmund.de Fachschaft E: fs.rp@tu-dortmund.de W: www.fsrp.de Alumni-Gesellschaft Raumplanung E: alumni

  12. In situ chemical fixation of arsenic-contaminated soils: An experimental study

    E-Print Network [OSTI]

    Yang, Li; Donahoe, Rona J.; Redwine, James C.

    2007-01-01T23:59:59.000Z

    permanganate and calcium carbonate were used as the reagentssolutions as an oxidant. Calcium carbonate was added to oneFS+PM); (3) ferrous sulfate, calcium carbonate and potassium

  13. Transact Workshop ---August 2007 Beyond Transactions

    E-Print Network [OSTI]

    Pratt, Vaughan

    Transact Workshop --- August 2007 Beyond Transactions The Evolution of Transactional Memory mechanisms with all resources Mem TM, FS LFS, Net message queues, DBMS Coordinate transactions across

  14. PLE FORMATION MDICALE CONTINUE

    E-Print Network [OSTI]

    Brest, Université de

    -brest.fr/fc #12;oBjeCtiFs Ce diplôme s'adresse aux médecins, cadres de santé, infirmiers, spécialisés ou non

  15. Nucl. Phys. B 628

    E-Print Network [OSTI]

    2002-03-29T23:59:59.000Z

    H. Saleur, B. Wehefritz-Kaufmann / Nuclear Physics B 628 [FS] (2002) 407–441. Remarkably, the chief non-perturbative method, the integrable approach, has ...

  16. Ultrafast Core-Hole Induced Dynamics in Water

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    isotope substitution experiments and molecular dynamics simulations, researchers from Sweden, Germany, and the U.S. have shown that the ultrafast (0- to 10-fs) dissociation...

  17. assistant medical technicians: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: FOREST fs.usda.govlolo Applications due by: December 2, 2012 Job Title: Lead Forestry Technician (AFEO) Duty Location: Missoula, MT Position Information: Full...

  18. antiguided vertical-cavity lasers: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    advantages for direct drive. KrFs demonstrated performance is competitive with solid state lasers as a high-rep-rate durable, efficient IFE driver. (on several important...

  19. addressable vertical-cavity laser: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    advantages for direct drive. KrFs demonstrated performance is competitive with solid state lasers as a high-rep-rate durable, efficient IFE driver. (on several important...

  20. Uranium Enrichment Decontamination and Decommissioning Fund's...

    Office of Environmental Management (EM)

    Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2008 and 2007 Financial Statement Audit, OAS-FS-10-05 Uranium Enrichment Decontamination and...

  1. E-Print Network 3.0 - ankyrin-repeat membrane protein Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    10 Stabilizing IB by "Consensus" Design Diego U. Ferreiro1,3 Summary: Keywords: protein folding; ankyrin repeat protein; NF-B; transcription factor; repeat protein...

  2. E-Print Network 3.0 - ankyrin protein networks Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    >> 21 Stabilizing IB by "Consensus" Design Diego U. Ferreiro1,3 Summary: Keywords: protein folding; ankyrin repeat protein; NF-B; transcription factor; repeat protein...

  3. Garden Patch Chili

    E-Print Network [OSTI]

    ... 17-ounce can corn kernels, drained Toppings of your choice (salsa, chopped red onions, chopped cilantro, nf yogurt, [avocado, cheese], etc.) 1. Drain beans.

  4. PROTON BEAM REQUIREMENTS FOR A NEUTRINO FACTORY AND MUON COLLIDER

    E-Print Network [OSTI]

    Zisman, Michael S.

    2010-01-01T23:59:59.000Z

    Table 1 summarizes the NF proton driver parameters obtainedboth facilities. Table 1. Proton driver requirements for arepetition frequency (Hz) Proton energy (GeV) Proton rms

  5. ITREOH building of regional capacity to monitor recreational water: Development of a non-commercial microcystin ELISA and its impact on public health policy

    E-Print Network [OSTI]

    2006-01-01T23:59:59.000Z

    International Center; Uruguay, Rio de la Plata; waterRepublica, Montevideo, Uruguay (BMB, LD, NF); the Laboratoryof Montev- ideo, Uruguay (BMB, DS); the National Direction

  6. Insights into the homeostatic regulation of I kappa B alpha

    E-Print Network [OSTI]

    Lisabeth, Erika Mathes

    2009-01-01T23:59:59.000Z

    Biol, 13, 1572-1582. Emmerich, F. , Meiser, M. , Hummel,fully inhibit NF-?B (Emmerich et al. , 1999; Jungnickel et

  7. amniotic membrane graft: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    by grafting of Engineering Websites Summary: of polyamide thin-film composite membranes. The structure of nanofiltration (NF) and reverse osmosis (RO.V. All rights...

  8. advanced membrane filtration: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    available reverse osmosis (RO) and nanofiltration (NF) membranes are based on the thin film composite (TFC) aromatic polyamide membranes. However, they have several disadvantages...

  9. Control of size and charge selectivity in amphiphilic graft copolymer nanofiltration membranes

    E-Print Network [OSTI]

    Lovell, Nathan Gary

    2010-01-01T23:59:59.000Z

    The throughput and efficiency of membrane separations make polymer filtration membranes an important resource for the pharmaceutical, food and wastewater treatment industries. Nanofiltration (NF) membranes fill an important ...

  10. Anti-inflammatory and anti-oxidative effects of corilagin in a rat model of acute cholestasis

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    MPO), malondialdehyde (MDA), superoxide dismutase (SOD) andintervention, levels of MPO, MDA and translocation of NF-?BMPO), malondialdehyde (MDA), super- oxide dismutase (SOD),

  11. air-stable planar chiral: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in QCD. One of the predictions of orientifold planar equivalence is that the chiral condensates of a theory with Nf flavours of Dirac fermions in the symmetric (or...

  12. Pre-Approved1 Chemical Engineering Technical Electives (NOTE: Technical Electives Engineering Electives Bioengineering Electives)2

    E-Print Network [OSTI]

    Dyer, Bill

    EELE 250 Circuits, Devices, and Motors [F,S] 4 EENV 340 Principles of Environmental Engineering [F,S] 3Pre-Approved1 Chemical Engineering Technical Electives (NOTE: Technical Electives Engineering Biochemistry of Macromolecules [F] 3 BIOB 256 Intro Biol: Cells to Organisms [S] 3+1 BIOB 375 General Genetics

  13. Anomalous density dependence of static friction in sand Viktor K. Horvath,1

    E-Print Network [OSTI]

    Jánosi, Imre M.

    Anomalous density dependence of static friction in sand Viktor K. Horva´th,1 Imre M. Ja´nosi,2; revised manuscript received 26 April 1996 We measured experimentally the static friction force Fs on the surface of a glass rod immersed in dry sand. We observed that Fs is extremely sensitive to the closeness

  14. Applied Physics A Materials Science & Processing

    E-Print Network [OSTI]

    Harilal, S. S.

    1 23 Applied Physics A Materials Science & Processing ISSN 0947-8396 Volume 117 Number 1 Appl. Phys. A (2014) 117:319-326 DOI 10.1007/s00339-014-8268-8 Background gas collisional effects on expanding fs at link.springer.com". #12;Background gas collisional effects on expanding fs and ns laser ablation plumes

  15. A Biomimetic Approach to Robot Table Tennis Katharina Mlling1,2, Jens Kober1,2, Jan Peters1,2

    E-Print Network [OSTI]

    and on a real anthropomorphic seven degrees of freedom Barrett WAMTM robot arm. keywords biomimetic robotics approaches, we use an anthropomorphic robot arm with seven degrees of freedom (DoFs) and concentrate is to generate human-like striking movements on an anthropomorphic robot arm with seven DoFs. We investigate

  16. CSE Master Specialization Fluid Dynamics

    E-Print Network [OSTI]

    Lang, Annika

    CSE Master Specialization Fluid Dynamics Course Semester Fluid Dynamics II HS Quantitative Flow Energie- und Verfahrenstechnik FS Biofluiddynamics FS #12;CSE in Fluid Dynamics: Very large high in Fluid Dynamics: Physiology of the inner ear MicroCT imaging Multilayer MFS for Stokes flow simulations

  17. Morten Bache group leader, moba@fotonik.dtu.dk

    E-Print Network [OSTI]

    Mosegaard, Klaus

    amplifiers t= constant What are ultra-short laser pulses? Mode locked lasers: Pulse trains, frequency combs Optics Why ultra-short pulses? Nanosurgery High-harmonic generation, attosecond pulses Micromachining Generating the shortest pulses anywhere in the spectrum Fs fiber laser amplifier Fs solid state laser

  18. The Australian National University (ANU) aims to establish a sustainable campus that demonstrates our corporate and

    E-Print Network [OSTI]

    0200 AUSTRALIA F&S SUSTAINABLE DESKTOP POWER MANAGEMENT November 2010 #12; Desktop Power Management solution is part of the Green ICT Project at the University. Facilities and Services Division (F&S) will be implementing power policies on desktops in a strategy to reduce its desktop

  19. May. 9, 2013 BBM 202 -ALGORITHMS

    E-Print Network [OSTI]

    Erdem, Erkut

    NAK SYN ETB CAN EM SUB ESC FS GS RS US 2 SP ! " # $ % & ` ( ) * + , - . / 3 0 1 2 3 4 5 6 7 8 9 ACK BEL BS HT LF VT FF CR SO SI 1 DLE DC1 DC2 DC3 DC4 NAK SYN ETB CAN EM SUB ESC FS GS RS US 2 SP

  20. 2013 FACT SHEET University of Florida Brevard County Extension

    E-Print Network [OSTI]

    Watson, Craig A.

    . FS# 6124 FCS #12;Holiday entertaining Unattended cooking is the leading cause of home fires in the U of sight and reach of children (preferably in a locked cabinet). When smokers visit your home, ask them Institute brevard.ifas.ufl.edu 321.633.1702 Enter FS# here Gayle Whitworth, Family & Consumer Sciences Agent

  1. Hydrothermal venting in magma deserts: The ultraslow-spreading Gakkel and Southwest Indian Ridges

    E-Print Network [OSTI]

    Langmuir, Charles H.

    and direct cooling of the upper mantle, and nonmagmatic heat supplied by exothermic serpentinization of spreading rate, establish a robust linear trend (Fs = 0.98 + 0.015us), implying that the long-term heat supply is the first-order control on the global distribution of hydrothermal activity. Normalizing Fs

  2. Lateral spin valves with two-different Heusler-alloy electrodes on the same platform

    SciTech Connect (OSTI)

    Oki, S.; Yamada, S.; Tanikawa, K.; Yamasaki, K.; Miyao, M.; Hamaya, K., E-mail: hamaya@ed.kyushu-u.ac.jp [Department of Electronics, Kyushu University, 744 Motooka, Fukuoka 819-0395 (Japan)

    2013-11-18T23:59:59.000Z

    Using room-temperature molecular beam epitaxy on Si(111), we demonstrate Heusler-alloy bilayers consisting of L2{sub 1}-Co{sub 2}FeSi (CFS) and D0{sub 3}-Fe{sub 3}Si (FS). By fabricating lateral spin valves with L2{sub 1}-CFS and D0{sub 3}-FS electrodes, we can see ideal spin signals even though we use one L2{sub 1}-CFS as a spin injector and another D0{sub 3}-FS as a spin detector. The difference in the spin absorption between L2{sub 1}-CFS and D0{sub 3}-FS can also be examined, and we find that the spin resistance of D0{sub 3}-FS is larger than that of L2{sub 1}-CFS. This work will be useful for understanding spin transport in lateral spin-valve devices with different Heusler-alloy electrodes.

  3. Computing Needs Time Edward A. Lee

    E-Print Network [OSTI]

    (CSR-CPS)), the U. S. Army Research Office (ARO #W911NF-07-2-0019), the U. S. Air Force Office essential prop- erties of the physical systems, most particularly the passage of time. It makes a case (CSR-CPS)), the U. S. Army Research Office (ARO #W911NF-07-2-0019), the U. S. Air Force Office

  4. MEETING ABSTRACT Open Access Predominant role of Tax sumoylation in

    E-Print Network [OSTI]

    Boyer, Edmond

    the NF-kB pathway by acting both at cytoplasmic and nuclear levels. In the cytoplasm, Tax binds to and activates the IkB Kinase (IKK) complex while in the nucleus, Tax assembles tran- scriptional active nuclear bodies. Others and we have previously demonstrated that the cytoplasmic/nuclear partition and NF

  5. Relating Interactions between Neurofilaments to the Structure of Axonal Neurofilament Distributions through Polymer Brush Models

    E-Print Network [OSTI]

    Kumar, Sanjay

    ; Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195 with the experimental observation that sidearm phosphor- ylation regulates interfilament spacing. The presence-L, 61 kDa in humans), medium (NF-M, 90 kDa), and heavy (NF-H, 110 kDa) (Lee and Cleveland, 1996

  6. Increasing Cancer-Specific Gene Expression by Targeting Overexpressed 51 Integrin and Upregulated Transcriptional

    E-Print Network [OSTI]

    Kokkoli, Efie

    Engineering and Materials Science, University of Minnesota, 421 Washington Ave SE, Minneapolis, Minnesota the control of an NF-B responsive element (pNF-B- Luc) encapsulated in a PR_b peptide functionalized stealth was seen when transfected with PR_b functionalized stealth liposomes encapsulating the condensed p

  7. Dr. Pete's useful stuff College Physics I*

    E-Print Network [OSTI]

    Nelson, Peter Hugo

    /nelson Hooke's Law & SHM Friction NfNf kkss µµ = kineticstatic Gravitation Quadratic functions ax2 + bx + c = 0 Momentum im= = p v P p rr rr Conservation laws for an isolated system i f i fE E P P= = simple pendulum k g

  8. Reason for Testing (Required-failure to include a diagnosis may delay testing. Include all pertinent diagnoses and ICD9 codes. Ie. Primary Lung Cancer 162.9 with metastasis to brain 198.3 and bone 198.5)

    E-Print Network [OSTI]

    Wang, David

    , NF1, NOTCH1, NPM1, NRAS, PDGFRA, PIK3CA, PTCH1, PTEN, PTPN11, RB1, RET, RUNX1, SMO, STK11, TET2, TP53 MAP2K2 MET MPL MTOR MYC MYD88 NF1 NOTCH1 NPM1 NRAS PDGFRA PIK3CA PTCH1 PTEN PTPN11 RB1 RET RUNX1 SMO

  9. TEA: Automatically proving termination of programs in a nonstrict higherorder functional

    E-Print Network [OSTI]

    Schmidt-Schauss, Manfred

    TEA: Automatically proving termination of programs in a non­strict higher­order functional language termination of functions written in a non­strict high­level functional programming language like Haskell kinds of termination: nf­termination and lazy termination. Intuitively, nf­termination of f means

  10. Quadratic and differential forms over function fields of Pfister quadrics in characteristic two*

    E-Print Network [OSTI]

    @inst-mat.utalca.cl Abstract Let F be a field of characteristic 2. Let nFbe the F-space of differ- ential + nV a db, then let nF= 1Fand d : nF ! n+1Fbe the differential operato

  11. The BMM Global-Local bijection for GL(n,q) fhm rinivsn

    E-Print Network [OSTI]

    Srinivasan, Bhama

    prtition of nF heorem @pongErinivsnA D re in the sme `Elok if nd only if D hve the sme eEoreF Bhama of nF heorem @pongErinivsnA D re in the sme `Elok if nd only if D hve the sme eEoreF Bhama Srinivasan

  12. ENEA F. Zonca 1 Multiple space-time structure of low-frequency fluctuations in

    E-Print Network [OSTI]

    Zonca, Fulvio

    techniques based on scale separation. 2 BF introduced by a number of authors in the late 70's (Coppi PRL77, Lee PFBW 77, Glasser PFBW 77, Pegoraro IAEA 78, Connor PRL 78, Dewar NF81) to conveniently treat (Coppi PRL77, Lee PFBW 77, Glasser PFBW 77, Pegoraro IAEA 78, Connor PRL 78, Dewar NF81) to conveniently

  13. A novel derivative of decursin, CSL-32, blocks migration and production of inflammatory mediators and modulates PI3K

    E-Print Network [OSTI]

    Lee, Won-Ha

    and Biotechnology, Kyungpook National University, Daegu 702-701, Korea { College of Pharmacy, Chungnam NationalB), phosphorylation of p65 subunit of NF-kB (nuclear factor-kB) and nuclear translocation of NF-kB, which are required

  14. Dmarche qualit au sein d'un laboratoire de recherche du CNRS: FEMTO-ST

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    également lancés dans la mise en place de la norme NF EN ISO 9001 afin d'obtenir une certification : recherche, qualité, laboratoires, label Carnot, ISO 9001, ISO/CEI 17025, Université de Franche-Comté, FEMTO décennies des laboratoires accrédités par le COFRAC selon le référentiel NF EN ISO/CEI 17025. Ainsi, le

  15. Neurofilament Proteins in Avian Auditory Hair Cells

    E-Print Network [OSTI]

    Rubel, Edwin

    Neurofilament Proteins in Avian Auditory Hair Cells ELIZABETH C. OESTERLE,* DIANA I. LURIE avian inner ear by using immunocytochemical techniques. NF-M was detected in auditory hair cells and VIIIth cranial nerve neurons. NF-M-positive hair cells are first detected at embryonic day 11 (E11

  16. ASPECTS OF PARTIAL INFORMATION IN DATABASES Leonid Libkin

    E-Print Network [OSTI]

    Libkin, Leonid

    {c7 38. Kg4{f5 Nf6:d5+ 13. h2{h3? Bc8{d7 39. Kf5{g4 Nd5{f6+ 14. Rb1{c1 g7{g6 40. Kg4{f5 Nf6{g8+ 15. Nf3{d2 Ra8{b8 41. Kf5{g4 Ng8{f6+ 16. Nd2{b3 Nc5:b3 42. Kg4{f5 Nf6{g8+ 17. Qc2:b3 c6{c5 43. Kf5{g4 Be7:g5 18. Kg1{h2 Kg8{h8 44. Kg4:g5 Rf8{f7 19. Qb3{c2 Nf6{g8 45. Bf2{h4 Rh6{g6+ 20. Be2{g4 Ng8{h6 46. Kg

  17. Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells

    SciTech Connect (OSTI)

    Tsujimoto, M.; Yip, Y.K.; Vilcek, J.

    1985-11-01T23:59:59.000Z

    Highly purified, Escherichia coli-derived recombinant human tumor necrosis factor (TNF) was labeled with /sup 125/I and employed to determine receptor binding, internalization, and intracellular degradation in murine L929 cells (highly sensitive to the cytotoxic action of TNF) and in diploid human FS-4 cells (resistant to TNF cytotoxicity). /sup 125/I-labeled TNF bound specifically to high-affinity receptors on both L929 and FS-4 cells. Scatchard analysis of the binding data indicated the presence of 2200 binding sites per L929 cell and 7500 binding sites per FS-4 cell. The calculated dissociation constants are 6.1 x 10/sup -10/ M and 3.2 x 10/sup -10/ M for L929 and FS-4 cells, respectively. In both L929 and FS-4 cells, incubation at 37/sup 0/C resulted in a rapid internalization of the bulk of the cell-bound TNF, followed by the appearance of trichloroacetic acid-soluble /sup 125/I radioactivity in the tissue culture medium, due to degradation of TNF. Degradation but not cellular uptake of TNF was inhibited in the presence of chloroquine (an inhibitor of lysosomal proteases) in both L929 and FS-4 cells, suggesting that degradation occurs intracellularly, probably within lysosomes. These results show that resistance of FS-4 cells to TNF cytotoxicity is not due to a lack of receptors or their inability to internalize and degrade TNF.

  18. Electron diffraction using ultrafast electron bunches from a laser-wakefield accelerator at kHz repetition rate

    SciTech Connect (OSTI)

    He, Z.-H.; Thomas, A. G. R.; Nees, J. A.; Hou, B.; Krushelnick, K. [Center for Ultrafast Optical Science, University of Michigan, Ann Arbor, Michigan 48106-2099 (United States)] [Center for Ultrafast Optical Science, University of Michigan, Ann Arbor, Michigan 48106-2099 (United States); Beaurepaire, B.; Malka, V.; Faure, J. [Laboratoire d'Optique Appliquee, ENSTA-CNRS-Ecole Polytechnique, UMR 7639, 91761 Palaiseau (France)] [Laboratoire d'Optique Appliquee, ENSTA-CNRS-Ecole Polytechnique, UMR 7639, 91761 Palaiseau (France)

    2013-02-11T23:59:59.000Z

    We show that electron bunches in the 50-100 keV range can be produced from a laser wakefield accelerator using 10 mJ, 35 fs laser pulses operating at 0.5 kHz. It is shown that using a solenoid magnetic lens, the electron bunch distribution can be shaped. The resulting transverse and longitudinal coherence is suitable for producing diffraction images from a polycrystalline 10 nm aluminum foil. The high repetition rate, the stability of the electron source, and the fact that its uncorrelated bunch duration is below 100 fs make this approach promising for the development of sub-100 fs ultrafast electron diffraction experiments.

  19. Effect of grain on silage characteristics for ruminants

    E-Print Network [OSTI]

    Groves, William Grady

    1977-01-01T23:59:59.000Z

    . pared the nutritional value of Oro-t, a grain type sorghum, and Fs-lb and Fs-la, two forage type grain sorghums (Bupp, 1973; I:upp, 1975; Spiegel, 1975; and Tolbert et al. , 1975). Tol'oert et al. (1975) indicated that dry matter digestibilities...;ver . enerally higher for she p fed Fs-lb, whereas nitrogen digestibilities and re- tention. ", -er higher f' or sheep fed Oro-t sila=es. They a' so discovered that increasin" head to . ,tover rations increas d d ~ matter digestibi'ities up to a 1:1 ratio...

  20. Observing heme doming in myoglobin with femtosecond X-ray absorption spectroscopya)

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Levantino, M.; Lemke, H. T.; Schirò, G.; Glownia, M.; Cupane, A.; Cammarata, M.

    2015-07-01T23:59:59.000Z

    We report time-resolved X-ray absorption measurements after photolysis of carbonmonoxy myoglobin performed at the LCLS X-ray free electron laser with nearly 100 fs (FWHM) time resolution. Data at the Fe K-edge reveal that the photoinduced structural changes at the heme occur in two steps, with a faster (~70 fs) relaxation preceding a slower (~400 fs) one. We tentatively attribute the first relaxation to a structural rearrangement induced by photolysis involving essentially only the heme chromophore and the second relaxation to a residual Fe motion out of the heme plane that is coupled to the displacement of myoglobin F-helix.