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1

FS Agre  

Office of Legacy Management (LM)

FS FS Agre em ent No . Cooperator Agreement No. Cooperator Agreement No . II II ~-IA 11 030200-0 ~ )V 2/3/11 INTERAGENCY AGREEMENT (IA) Between the UNITED STATES DEPARTMENT OF ENERGY (DOE) OFFICE OF LEGACY MANAGEMENT and the UNITED STATES DEPARTMENT OF THE INTERIOR BUREAU OF LAND MANAGEMENT (BLM) FARMINGTON FIELD OFFICE and the UNITED STATES DEPARTMENT OF AGRICULTURE (USDA) FOREST SERVICE CARSON NATIONAL FOREST TITLE: Gasbuggy Site on the Carson National Forest Property Description The Gasbuggy Site is in northwestern New Mexico in Rio Arriba County, approximately 55 miles east of the city of Farmington, New Mexico, and approximately 12 miles southwest of Dulce, New Mexico, in the Carson National Forest. The Gasbuggy Site consists of 640 acres withdrawn under Public Land Order (PLO) 4232 (Sec. 36, T. 29N, R. 4W , NMPM). On December 10, 1967, the U.S. Atomic Energy Commission

2

FACILITY SAFETY (FS)  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

FACILITY SAFETY (FS) FACILITY SAFETY (FS) OBJECTIVE FS.1 - (Core Requirement 7) Facility safety documentation in support of SN process operations,is in place and has been implemented that describes the safety envelope of the facility. The, safety documentation should characterize the hazards/risks associated with the facility and should, identify preventive and mitigating measures (e.g., systems, procedures, and administrative, controls) that protect workers and the public from those hazards/risks. (Old Core Requirement 4) Criteria 1. A DSA has been prepared by FWENC, approved by DOE, and implemented to reflect the SN process operations in the WPF. (10 CFR 830.200, DOE-STD-3009-94) 2. A configuration control program is in place and functioning such that the DSA is

3

DOEIEIS-0245-FS/SA2  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

DOEIEIS-0245-FS/SA2 DOEIEIS-0245-FS/SA2 . ~ .... -. .:: I :: . 1 .' Supplement Analysis Alternate Fuel Transfer for the 105-KE Basin Spent Nuclear Fuel, 100 K Area, Hanford Site, Richland, Washington August 2001 U.S. Department of Energy Richland Operations Office Richland, Washington 99352 INTRODUCTION The U.S. Department of Energy (DOE) is planning to transfer spent nuclear fuel (SNF) from the lOS-KE Basin (KE) to the lOS-KW Basin (KW) to package the SNF into multi-canister overpacks (MCOs) using existing equipment at KW. The MCOs would be transported to the existing Cold Vacuum Drying Facility (CVDF) at KW for vacuum drying and transferred to the 200 East Area Canister Storage Building (CSB). Approxima.tely 1,200 metric tons (1,323 tons) of SNF are stored under water in 3,673 open canisters

4

Financial Statement: IG-FS-CA-06-04  

Energy.gov (U.S. Department of Energy (DOE))

Review of Actions to Correct Financial Control and Reporting Weaknesses; Audit Report No: OAS-FS/CA-06-04

5

Making Linux protection mechanisms egalitarian with UserFS  

Science Conference Proceedings (OSTI)

UserFS provides egalitarian OS protection mechanisms in Linux. UserFS allows any user--not just the system administrator--to allocate Unix user IDs, to use chroot, and to set up firewall rules in order to confine untrusted code. One key idea in UserFS ...

Taesoo Kim; Nickolai Zeldovich

2010-08-01T23:59:59.000Z

6

GlusterFS One Storage Server to Rule Them All  

SciTech Connect

GlusterFS is a Linux based distributed file system, designed to be highly scalable and serve many clients. Some reasons to use GlusterFS are: No centralized metadata server, Scalability, Open Source, Dynamic and live service modifications, Can be used over Infiniband or Ethernet, Can be tuned for speed and/or resilience and Flexible administration. It's useful for enterprise environments - virtualization; high performance computing (HPC) and it works with Mac, Linux and Windows clients. Conclusions are: (1) GlusterFS proved to have widespread capabilities as a virtual file system; (2) Scalability is very dependent upon the underlying hardware; (3) Lack of built-in encryption and security paradigm; and (4) Best suited in a general purpose computing environment.

Boyer, Eric B. [Los Alamos National Laboratory; Broomfield, Matthew C. [Los Alamos National Laboratory; Perrotti, Terrell A. [Los Alamos National Laboratory

2012-07-30T23:59:59.000Z

7

File:1200CappFS.pdf | Open Energy Information  

Open Energy Info (EERE)

CappFS.pdf CappFS.pdf Jump to: navigation, search File File history File usage File:1200CappFS.pdf Size of this preview: 463 × 599 pixels. Other resolution: 464 × 600 pixels. Go to page 1 2 Go! next page → next page → Full resolution ‎(1,275 × 1,650 pixels, file size: 173 KB, MIME type: application/pdf, 2 pages) File history Click on a date/time to view the file as it appeared at that time. Date/Time Thumbnail Dimensions User Comment current 17:00, 19 November 2012 Thumbnail for version as of 17:00, 19 November 2012 1,275 × 1,650, 2 pages (173 KB) Dklein2012 (Talk | contribs) You cannot overwrite this file. Edit this file using an external application (See the setup instructions for more information) File usage There are no pages that link to this file. Retrieved from

8

Semester Project FS 2014 Focus on Energy, Flow  

E-Print Network (OSTI)

to the chamber for liquefied Xe. Liquid nitrogen will be used as a coolant. The major challenge with this projectSemester Project ­ FS 2014 Focus on Energy, Flow and Processes Cryogenic Feed System for liquefied temperatures to keep the fuel in a liquefied state (

Daraio, Chiara

9

CEC-500-2010-FS-002 Assess New Transportation  

E-Print Network (OSTI)

CEC-500-2010-FS-002 Assess New Transportation and Land-Use Patterns in a Carbon-Constrained Future TRANSPORTATION ENERGY RESEARCH PIER Transportation Research www.energy.ca.gov/research/ transportation/ March 2010 The Issue California's transportation sector is the single largest contributor of greenhouse gas

10

CEC-500-2010-FS-001 Algae OMEGA  

E-Print Network (OSTI)

infrastructure system. · Enhance the supply and affordability of future transportation fuel choicesCEC-500-2010-FS-001 Algae OMEGA (Offshore Membrane Enclosures For Growing Algae) TRANSPORTATION ENERGY RESEARCH PIER Transportation Research www.energy.ca.gov/research/ transportation/ March 2010

11

Financial Statement: WR-FS-09-04 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Office during the Audit of The Department of Energy's Consolidated Fiscal year 1998 Financial Statements WR-FS-99-04.PDF More Documents & Publications Report: WR-FS-99-02...

12

Financial Statement: IG-FS-02-01 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

IG-FS-02-01 February 13, 2002 Report on the Department of Energy's Consolidated Financial Statements IG-FS-02-01.pdf More Documents & Publications Audit Report:...

13

Finanacial Statement: WR-FS-99-02 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Office During the Audit of the Department of Energy's Consolidated Fiscal Year 1998 Financial Statements WR-FS-99-02.PDF More Documents & Publications Report: WR-FS-99-02...

14

Financial Statement: IG-FS-04-02 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Statement: IG-FS-04-02 December 5, 2003 Report on the Department of Energy's Consolidated Financial Statements OAS-FS-04-02.pdf More Documents & Publications Financial Statement:...

15

Financial Statement: IG-FS-01-01 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

IG-FS-01-01 February 16, 2001 Report on the Department of Energy's Consolidated Financial Statements IG-FS-01-01.pdf More Documents & Publications Financial Statement:...

16

Audit Report: IG-FS-99-01 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

IG-FS-99-01 Audit Report: IG-FS-99-01 February 25, 1999 Audit Of The U.S Department Of Energy's Consolidated Financial Statements For Fiscal Year 1998 We have audited the...

17

Audit Report: CR-FS-97-02 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

7-02 Audit Report: CR-FS-97-02 May 1, 1997 Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 1996 Audit Report: CR-FS-97-02 More Documents &...

18

Audit Report: OAS-FS-07-02 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

OAS-FS-07-02 OAS-FS-07-02 Audit Report: OAS-FS-07-02 November 13, 2006 Report on the Department of Energy's Fiscal Year 2006 Consolidated Balance Sheet In response to requirements established by the Government Management Reform Act of 1994, the Office of Inspector General engages the independent public accounting for of KMPG LLP to audit the Department of Energy's Fiscal Year (FY) 2006 consolidated balance sheet. The contractor was engages to audit only the balance sheet because a material weakness in financila control and reporting resulted in a disclaimer of opinion on the FY 2005 Audit of the Department's Consolidated Financial Statements. Audit Report: OAS-FS-07-02 More Documents & Publications Financial Statement: OAS-FS-07-02 Audit Report: OAS-FS-12-04 Audit Report: OAS-FS-11-04

19

Evidence of Coverage 3.2-1KE FS 624 HDBK  

E-Print Network (OSTI)

#12;#12;#12;#12;#12;Evidence of Coverage 3.2-1KE FS 624 HDBK TOC Table of Contents Required the Notice for detailed information regarding their privacy rights. KE FS 624 HDBK DIS #12;3.2-3 Welcome by Hospitals if they have questions about your coverage. KE FS 624 HDBK WEL #12;3.2-4 Using The HMO System

Boufadel, Michel

20

The REMOTE SENSlNf  

Office of Legacy Management (LM)

REMOTE REMOTE SENSlNf ' . 1 ARllRllRRv OF THE UNITED STATES DEPARTMENT OF ENERGY . . . . .a. * ~~&hrEAWWMms Gap ~~&hrEAwwMms Gap ECT FOLLdW-UP REPORT ECT FOLLdW-UP REPORT NOVEMBER 1979 NOVEMBER 1979 AN AERIAL RADIOLOGICAL SURVEY OF THE CURTIS BAY FACILITY OF THE W. FL GRACE COMPANY Baltimore, Maryland t. Kent Hilton Project Scientist APPROVED FORPUBLlCATlON ' : T. P. Stuart, Manager Remote Sensing Sciences Department ATTACHMENT 4- ECT Follow-Up Report AN AERIAL RADIOLOGICAL SURVEY OF THE CURTIS BAY FACILITY This is the second of two reports discussing the gamma ray radiation levels measured at the Curtis Bay facility of the W. R. Grace Company. The first report presented gross count contours and gamma ray spectra over the most active areas. Refined gross count isopleth maps will be

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Finanacial Statement: WR-FS-99-01 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Operations Office during The Audit of The Department's Consolidated Fiscal year 1998 Financial Statements WR-FS-99-01.PDF More Documents & Publications Audit Report:...

22

Audit Report: WR-FS-97-04 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Operations Office During the Audit of the Department's Consolidated Fiscal Year 1996 Financial Statements Audit Report: WR-FS-97-04 More Documents & Publications Audit Report:...

23

Financial Statement: WR-FS-00-01 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Hanford Site during the Audit of The Department of Energy's Consolidated Fiscal year 1999 Financial Statements WR-FS-00-01.pdf More Documents & Publications Finanacial Statement:...

24

Audit Report: OAS-FS-11-06 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

of budgetary resources for the year ended September 30, 2007 (hereinafter referred to as "financial statements"). Audit Report: OAS-FS-11-06 More Documents & Publications Audit...

25

Finanacial Statement: WR-FS-09-03 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Office during the Audit of The Department of Energy's Consolidated Fiscal Year 1998 Financial Statements WR-FS-99-03.PDF More Documents & Publications Financial Statement:...

26

Financial Statement: WR-FS-00-02 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Office During The Audit of The Department of Energy's Consolidated Fiscal Year 1999 Financial Statements WR-FS-00-02.pdf More Documents & Publications Audit Report:...

27

Audit Report: OAS-FS-10-05 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

Report: OAS-FS-10-05 February 18, 2010 Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2008 and 2007 Financial Statement Audit Audit Report:...

28

Audit Report: OAS-FS-10-06 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

6 Audit Report: OAS-FS-10-06 April 21, 2010 Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2009 Financial Statement Audit The attached report presents...

29

Microsoft Word - 25788WDC_DOE DD FS.docx  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

June 14, 2011 June 14, 2011 REPLY TO ATTN OF: IG-35 (A10FN003) SUBJECT: Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2010 Financial Statement Audit - Report No.: OAS-FS-11-07 TO: Assistant Secretary for Environmental Management, EM-1 Deputy Assistant Secretary for Program Planning and Budget, Office of Environmental Management, EM-60 The attached report presents the results of the independent certified public accountants' audit of the United States Department of Energy's Uranium Enrichment Decontamination and Decommissioning Fund's (D&D Fund) Fiscal Year (FY) 2010 balance sheet and the related statements of net cost, changes in net position, and budgetary resources. The Office of Inspector General (OIG) engaged the independent public accounting firm

30

Audit Report: OAS-FS-09-06 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

6 6 Audit Report: OAS-FS-09-06 August 26, 2009 Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2006 and 2005 Financial Statement Audit The attache report presents the results of the independent certified public accountants' audit of the United States Department of Energy's Uranium Enrichment Decontamination Decommissioning Fund's (D&D Fund) Fiscal Year (FY) 2006 and 2005 balance sheets and the related statements of net cost, changes in net position (deficit), budgetary resources and financing. Audit Report: OAS-FS-09-06 More Documents & Publications Audit Report: OAS-FS-10-05 Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2008 and 2007 Financial Statement Audit, OAS-FS-10-05 Audit Report: OAS-FS-13

31

Audit Report: OAS-FS-13-05 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Audit Report: OAS-FS-13-05 » Audit Report: OAS-FS-13-05 Audit Report: OAS-FS-13-05 » Audit Report: OAS-FS-13-05 Audit Report: OAS-FS-13-05 November 28, 2012 Department of Energy's Nuclear Waste Fund's Fiscal Year 2012 Financial Statement Audit KPMG, LLP (KPMG) audited the Department of Energy's Nuclear Waste Fund's (Fund) Fiscal Year 2012 balance sheet and the related statements of net cost, changes in net position and budgetary resources. KPMG concluded that the financial statements present fairly, in all material respects, the financial position of the Fund as of September 30, 2012 and 2011, and its net costs, changes in net position, and budgetary resources for the years then ended, in conformity with United States generally accepted accounting principles. The auditors' review of the Fund's internal control structure and

32

Audit Report: IG-FS-97-01 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

IG-FS-97-01 February 26, 1997 Audit of The U.S. Department of Energy's Consolidated Financial Statements for Fiscal Year 1996 To obtain a copy of this report please email the...

33

Audit Report: IG-FS-96-01 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

6-01 Audit Report: IG-FS-96-01 February 29, 1996 Audit of The U.S. Department of Energy's Consolidated Statement of Financial Position (as of September 30, 1995) Audit Report:...

34

Audit Report: OAS-FS-11-02 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

2 Audit Report: OAS-FS-11-02 November 9, 2010 Federal Energy Regulary commission's Fiscal Year 2010 Financial Statement Audit The report presents the results of the independent...

35

Audit Report: OAS-FS-09-02 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

2 Audit Report: OAS-FS-09-02 November 13, 2008 Federal Energy Regulatory Commission's Fiscal Year 2008 Financial Statement Audit Report The attached report presents the results of...

36

Audit Report: OAS-FS-13-11 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

11 Audit Report: OAS-FS-13-11 January 31, 2013 Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2010 Balance Sheet...

37

Audit Report: OAS-FS-11-01 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

1 Audit Report: OAS-FS-11-01 November 12, 2010 Report on the Department of Energy's Fiscal Year2010 Consolidated Financial Statements This is to inform you that the audit of the...

38

Molecular Cell XIAP Induces NF-kB Activation  

E-Print Network (OSTI)

Molecular Cell Article XIAP Induces NF-kB Activation via the BIR1/TAB1 Interaction and BIR1 NF-kB and MAP kinase activation during TGF-b and BMP receptor signaling and upon overexpression. Here with TAB1 to induce NF-kB activation. TAB1 is an upstream adaptor for the activation of the kinase TAK1

Wu, Hao

39

NF kappa B expression and matrix metalloproteinase activity in hypertension  

E-Print Network (OSTI)

299-306, 1995. Baldwin A.S. The NF-kB and IkB Proteins: Newof transcription factor NF-kB in mouse glomerular mesangialwere then labeled with anti-NF-kB p65 rabbit polyclonal

Wu, Kwan-I

2009-01-01T23:59:59.000Z

40

Remedial Investigation/Feasibility Study (RI/FS) process, elements and techniques guidance  

SciTech Connect

This manual provides detailed guidance on Remedial Investigation/Feasibility Studies (RI/FSs) conducted pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) at Department of Energy (DOE) facilities. The purpose of the RI/FS, to assess the risk posed by a hazardous waste site and to determine the best way to reduce that risk, and its structure (site characterization, risk assessment, screening and detailed analysis of alternatives, etc.) is defined in the National Oil and Hazardous Substances Pollution Contingency Plan (NCP) and further explained in the Environmental Protection Agency`s (EPA`s) Guidance for Conducting Remedial Investigations and Feasibility Studies Under CERCLA (Interim Final) 540/G-89/004, OSWER Directive 9355.3-01, October 1988. Though issued in 1988, the EPA guidance remains an excellent source of information on the conduct and structure of an RI/FS. This document makes use of supplemental RI/FS-related guidance that EPA has developed since its initial document was issued in 1988, incorporates practical lessons learned in more than 12 years of experience in CERCLA hazardous site remediation, and drawing on those lessons, introduces the Streamlined Approach For Environmental Restoration (SAFER), developed by DOE as a way to proceed quickly and efficiently through the RI/FS process at DOE facilities. Thus as its title implies, this guidance is intended to describe in detail the process and component elements of an RI/FS, as well as techniques to manage the RI/FS effectively.

Not Available

1993-12-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Influence of process changes on PCDD/Fs produced in an iron ore sintering plant  

Science Conference Proceedings (OSTI)

This study investigated the influence of different charge typologies and additives on the PCDD/Fs amount produced and on the congener profiles in an iron ore sintering plant. Many tests were carried out combining different typologies of charge (iron materials) and solid fuel ('coke breeze' or 'anthracite') with or without the use of urea. The PCDD/Fs produced ranged from 1.2 to 22.7 {mu} g I-TEQ/ton of agglomerate, whereas the PCDD/Fs released to the ambient air ranged from 0.10 to 1.92 ng I-TEQ/Nm{sup 3} because of cleaning in an electrostatic precipitator (ESP) and a Wetfine scrubber (WS). A more homogeneous charge with a higher amount of fine particles charge appeared to produce a lower PCDD/Fs concentration due to a better combustion but this hypothesis needs further investigations on charges having different dimension particles. Only a synergitic action of urea and anthracite was able to reduce the high PCDD/Fs content due to the bad combustion of the more inhomogeneous charge with a lower amount of fine particles. The congener profile was a typical combustion process fingerprint because the PCDFs predominated, the highly chlorinated congeners (HeptaCDD and OctaCDD) prevailed in PCDDs, whereas in PCDFs the profile was more varied; 1,2,3,4,6,7,8-HeptaCDF was the main contributor to the total concentration while 2,3,4,7,8-PentaCDF was the main contributor to the I-TEQ concentration. Whereas all the parameters under scrutiny influenced strongly the amount of PCDD/Fs produced, they affected only slightly the fingerprint of PCDD/Fs. In all cases studied, the reduction obtained using urea, anthracite, or the more homogeneous charge with a higher amount of fine particles was slightly greater on the higher chlorinated congeners in respect to the lower ones.

Guerriero, E.; Bianchini, M.; Gigliucci, P.F.; Guarnieri, A.; Mosca, S.; Rossetti, G.; Varde, M.; Rotatori, M. [CNR, Monterotondo (Italy)

2009-01-15T23:59:59.000Z

42

Audit Report: OAS-FS-13-01 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Audit Report: OAS-FS-13-01 Audit Report: OAS-FS-13-01 Audit Report: OAS-FS-13-01 September 30, 2012 Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2011 Financial Statement Audit The Office of Inspector General (OIG) engaged the independent public accounting firm of KPMG, LLP (KPMG) to perform an audit of the United States Department of Energy's Uranium Enrichment Decontamination and Decommissioning (D&D) Fund's FY 2011 financial statements. KPMG concluded that the financial statements present fairly, in all material respects, the financial position of the D&D Fund as of September 30, 2011, and its net costs, changes in net position, and budgetary resources, in conformity with United States generally accepted accounting principles. As part of this review, the auditors also considered the D&D Fund's

43

Audit Report: OAS-FS-13-08 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

OAS-FS-13-08 OAS-FS-13-08 Audit Report: OAS-FS-13-08 December 17, 2012 Management Letter on the Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 2012 KPMG, LLP noted certain matters involving internal control and other operational matters during their audit of the Department of Energy's (Department) Consolidated Financial Statements for Fiscal Year (FY) 2012. These matters are intended to improve the Department's internal controls or result in other operational efficiencies. The management letter contains 16 new findings and 7 repeat findings that were issued during the course of the FY 2012 Audit of the Department's Consolidated Financial Statements. Management generally concurred with and provided planned corrective actions for most of the recommendations

44

Cloning and expression of equine NF-kB2  

E-Print Network (OSTI)

Equine infectious anemia virus (EIAV) is a macrophage-tropic retrovirus that causes persistent disease in horses and ponies. In addition to its structural proteins, EIAV encodes four regulatory/accessory genes, tat, rev, ttm, and S2. It has been documented EIAV S2 gene expression is essential for disease expression of EIAV. Using a yeast two-hybrid assay, it was shown that S2 protein interacts with human NF-KB2. NF-KB2 plays a key role in the alternative or non-canonical NF-KB pathway. In order to determine if the interaction of S2 with NF-KB2 might be relevant to equine disease, a cDNA representing full length equine NF-KB2 was generated in our laboratory using PCR and rapid amplification of cDNA ends. To our knowledge this is the first time that equine NF-KB2 cDNAs have been recovered and characterized. The sequence of equine NF-KB2 was 95% homologous to human overall, however a major difference was found in the ankyrin repeat region where protein-protein interactions occur. Two splice variants of equine NF-KB2 were found that correspond to splice variants of human NF- KB2. We tested the interaction of EIAV S2 and equine NF-KB2 using the yeast two hybrid system (Y2H) and co-immunoprecipitation. Unfortunately we were not able to detect an interaction between EIAV S2 and equine NF-KB2 in either system. Despite this result, NF-KB2 is an important component in the immune response so we examined its expression in equine macrophages. Moreover we were interested to know if EIAV might affect expression levels of equine NF-KB2, as NF-KB2 is a target of other viruses. Hence, the expression level of equine NF-KB2 was measured in uninfected and infected primary equine monocyte- derived macrophage (eMDM). Using quantitative PCR we determined that equine NF-KB2 gene expression is decreased in eMDM after 3 days post plating, about the time that monocytes start to differentiate into mature macrophages. However EIAV infection of eMDM upregulated the expression level of NF-KB2.

Mirhosseini, Negin

2008-05-01T23:59:59.000Z

45

CMRR-NF SEIS Scoping Information | National Nuclear Security...  

National Nuclear Security Administration (NNSA)

OctoberNovember 2010 Scoping meeting posters Welcome How You Can Submit Your Comments LANL Technical Areas Chemistry and Metallurgy Research Replacement (CMRR) CMRR-NF SEIS...

46

A NF-kappaB temporal code to ensure specificity in inflammatory signaling  

E-Print Network (OSTI)

requires the interaction of NF-kB with other transcriptionD. 2006. Circuitry of NF-kB Signaling. Immunological Reviewscontrol the dynamics of NF-kB signaling and gene expression.

Werner, Shannon L.

2009-01-01T23:59:59.000Z

47

Quantitative characterization and analysis of the dynamic NF-kappaB response in microglia  

E-Print Network (OSTI)

J, Wirth T, Schwaninger M: NF- kB is activated and promotesdomains of A20 downregulate NF-kB signalling. Nature 2004,Levchenko A: Understanding NF-kB signaling via mathematical

Sheppard, Patrick W; Sun, Xiaoyun; Emery, John F; Giffard, Rona G; Khammash, Mustafa

2011-01-01T23:59:59.000Z

48

Temporal encoding and homeostatic control in the IKK- kappaNF-kappaB signaling system  

E-Print Network (OSTI)

to control constitutive NF-kB activity." Molecular SystemsPharmacological Inhibitors on NF-kB Activation TimecoursesPharmacological Inhibitors on NF-kB Activation 102 x

Barken, Derren

2007-01-01T23:59:59.000Z

49

Abstract--Efficient scheduling for heterogeneous fractional lambda switching (FS) networks is required but  

E-Print Network (OSTI)

rates. Moreover, when non-immediate forwarding (NIF) is used in FS, it increases the scheduling complexity exponentially, while decreasing the blocking probability. Thus, NIF scheduling presents a serious forwarding - IF or (2) non- immediate forwarding ­ NIF (see Section II.B). We address the NIF scenarios since

Baldi, Mario

50

Satellite Remote Sensing and GIS -FS 2011 The aims of this course are threefold  

E-Print Network (OSTI)

Programme Satellite Remote Sensing and GIS - FS 2011 Aims The aims of this course are threefold of satellite remote sensing, often in relation to GIS, in different disciplines with invited speakers from about what is happening with satellite remote sensing in Switzerland and how it works in professional

Giger, Christine

51

Satellite Remote Sensing and GIS -FS 2012 The aims of this course are threefold  

E-Print Network (OSTI)

Programme Satellite Remote Sensing and GIS - FS 2012 Aims The aims of this course are threefold of satellite remote sensing, often in relation to GIS, in different disciplines with invited speakers from about what is happening with satellite remote sensing in Switzerland and how it works in professional

Giger, Christine

52

Satellite Remote Sensing and GIS -FS 2013 The aims of this course are threefold  

E-Print Network (OSTI)

Programme Satellite Remote Sensing and GIS - FS 2013 Aims The aims of this course are threefold of satellite remote sensing, often in relation to GIS, in different disciplines with invited speakers from about what is happening with satellite remote sensing in Switzerland and how it works in professional

Giger, Christine

53

CEC-500-2010-FS-XXX The Advanced Natural Gas  

E-Print Network (OSTI)

as an alternative transportation fuel in California. In addition, natural gas storage options are expensive, flat panel natural gas storage tanks in vehicles and at fueling stations. PIER Program ObjectivesCEC-500-2010-FS-XXX The Advanced Natural Gas Vehicle Fuel Tank Project TRANSPORTATION ENERGY

54

Semesterplan WS 2012/13 Chemie (VL) fr Zahnmediziner (1. FS) Stand. 02.10.2012 Mo 22. Okt.  

E-Print Network (OSTI)

Semesterplan WS 2012/13 Chemie (VL) für Zahnmediziner (1. FS) Stand. 02.10.2012 Mo 22. Okt;Semesterplan WS 2012/13 Chemie (VL) für Zahnmediziner (1. FS) Stand. 02.10.2012 Mo 17. Dez. 10.15 11

Gollisch, Tim

55

Test 4, "NMR Spectroscopy", Chem416, FS93, Dr. Glaser --1 --Chemistry 416 "Spectroscopy"Chemistry 416 "Spectroscopy"  

E-Print Network (OSTI)

Test 4, "NMR Spectroscopy", Chem416, FS93, Dr. Glaser -- 1 -- Chemistry 416 "Spectroscopy "Take Home" Examination "NMR Spectroscopy" Hand-out: Wednesday, December 1, 1993 Collect: Friday Question 4 (13C Inc. Sys.) 20 Total 100 #12;Test 4, "NMR Spectroscopy", Chem416, FS93, Dr. Glaser -- 2

Glaser, Rainer

56

Homeostatic control of IkappaB metabolism determines NF- kappaB responsiveness  

E-Print Network (OSTI)

A. , and Ghosh, G. 2007. NF-kB dictates IkB degradationI?B protein within the NF-kB signaling module. Cell. 128:

O'Dea, Ellen Louise

2010-01-01T23:59:59.000Z

57

Electron Bunch Profile Reconstruction in the Few fs Regime using Coherent Smith-Purcell Radiation  

SciTech Connect

Advanced accelerators for fourth generation light sources based on high brightness linacs or laser-driven wakefield accelerators will operate with intense, highly relativistic electron bunches that are only a few fs long. Diagnostic techniques for the determination of temporal profile of such bunches are required to be non invasive, single shot, economic and with the required resolution in the fs regime. The use of a radiative process such as coherent Smith-Purcell radiation (SPR), is particularly promising with this respect. In this technique the beam is made to radiate a small amount of electromagnetic radiation and the temporal profile is reconstructed from the measured spectral distribution of the radiation. We summarise the advantages of SPR and present the design parameters and preliminary results of the experiments at the FACET facility at SLAC. We also discuss a new approach to the problem of the recovery of the 'missing phase', which is essential for the accurate reconstruction of the temporal bunch profile.

Bartolini, R.; /Oxford U., JAI /Diamond Light Source /SLAC; Clarke, C.; /SLAC; Delerue, N; /Oxford U., JAI /Diamond Light Source /SLAC; Doucas, G; Reichold, A; /Oxford U., JAI

2012-06-20T23:59:59.000Z

58

Audit Report: WR-FS-99-01 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

9-01 9-01 Audit Report: WR-FS-99-01 March 16, 1999 Report On Mater Identified At the Idaho Operations Office During The Audit Of The Department's Consolidated Fiscal Year 1998 Financial Statements The Government Management Reform Act of 1994 requires that the Department of Energy (DOE) annually submit audited financial statements to the Office of Management and Budget (OMB). A Departmentwide audit was conducted to determine whether there was reasonable assurance that DOE's consolidated Fiscal Year (FY) 1998 financial statements were free of material misstatements. We conducted a portion of the Departmentwide audit at the Idaho Operations Office (Idaho) and its management and operating contractor, Lockheed Martin Idaho Technologies Company (Lockheed). Audit Report: WR-FS-99-01

59

Modulation of the NF-kB Pathway by Bordetella  

E-Print Network (OSTI)

Background: Filamentous hemagglutinin (FHA) is a cell-associated and secreted adhesin produced by Bordetella pertussis with pro-apoptotic and pro-inflammatory activity in host cells. Given the importance of the NF-kB transcription factor family in these host cell responses, we examined the effect of FHA on NF-kB activation in macrophages and bronchial epithelial cells, both of which are relevant cell types during natural infection. Methodology/Principal Findings: Exposure to FHA of primary human monocytes and transformed U-937 macrophages, but not BEAS-2B epithelial cells, resulted in early activation of the NF-kB pathway, as manifested by the degradation of cytosolic IkBa, by NF-kB DNA binding, and by the subsequent secretion of NF-kB-regulated inflammatory cytokines. However, exposure of macrophages and human monocytes to FHA for two hours or more resulted in the accumulation of cytosolic IkBa, and the failure of TNF-a to activate NF-kB. Proteasome activity was attenuated following exposure of cells to FHA for 2 hours, as was the nuclear translocation of RelA in BEAS-2B cells. Conclusions: These results reveal a complex temporal dynamic, and suggest that despite short term effects to the contrary, longer exposures of host cells to this secreted adhesin may block NF-kB activation, and perhaps lead to a compromised immune response to this bacterial pathogen.

Pertussis Filamentous Hemagglutinin; Tzvia Abramson; Hassya Kedem; David A. Relman

2008-01-01T23:59:59.000Z

60

File:FS Form 2800-16.pdf | Open Energy Information  

Open Energy Info (EERE)

FS Form 2800-16.pdf FS Form 2800-16.pdf Jump to: navigation, search File File history File usage File:FS Form 2800-16.pdf Size of this preview: 463 × 599 pixels. Other resolution: 464 × 600 pixels. Go to page 1 2 3 Go! next page → next page → Full resolution ‎(1,275 × 1,650 pixels, file size: 119 KB, MIME type: application/pdf, 3 pages) File history Click on a date/time to view the file as it appeared at that time. Date/Time Thumbnail Dimensions User Comment current 14:24, 5 November 2012 Thumbnail for version as of 14:24, 5 November 2012 1,275 × 1,650, 3 pages (119 KB) Dklein2012 (Talk | contribs) You cannot overwrite this file. Edit this file using an external application (See the setup instructions for more information) File usage There are no pages that link to this file.

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Kinetics of NF-kB nucleocytoplasmic transport probed by single-cell screening without imaging  

E-Print Network (OSTI)

Kinetics of NF-kB nucleocytoplasmic transport probed by single-cell screening without imaging Jun of nucleocytoplasmic transport of an important transcription factor NF-kB. With data collected from single cells, we activation barrier for NF-kB transport. Our data demonstrate that NF-kB nucleocytoplasmic transport fits

Lu, Chang

62

Charting the NF-kB Pathway Interactome Map  

E-Print Network (OSTI)

Inflammation is part of a complex physiological response to harmful stimuli and pathogenic stress. The five components of the Nuclear Factor kB (NF-kB) family are prominent mediators of inflammation, acting as key transcriptional regulators of hundreds of genes. Several signaling pathways activated by diverse stimuli converge on NF-kB activation, resulting in a regulatory system characterized by high complexity. It is increasingly recognized that the number of components that impinges upon phenotypic outcomes of signal transduction pathways may be higher than those taken into consideration from canonical pathway representations. Scope of the present analysis is to provide a wider, systemic picture of the NF-kB signaling system. Data from different sources such as literature, functional enrichment web resources, protein-protein interaction and pathway databases have been gathered, curated, integrated and analyzed in order to reconstruct a single, comprehensive picture of the proteins that interact with, and participate to the NF-kB activation system. Such a reconstruction shows that the NF-kB interactome is substantially different in quantity and quality of components with respect to canonical representations. The analysis highlights that several neglected but topologically central proteins may play a role in the activation of NF-kB mediated responses. Moreover the interactome structure fits with the characteristics of a bow tie architecture. This interactome is intended as an open network resource available for further development,

Paolo Tieri; Alberto Termanini; Elena Bellavista; Stefano Salvioli; Miriam Capri

2011-01-01T23:59:59.000Z

63

Southwestern Federal Power System's Fiscal Year 2011 Financial Statement Audit, OAS-FS-13-06  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Southwestern Federal Power Southwestern Federal Power System's Fiscal Year 2011 Financial Statement Audit OAS-FS-13-06 November 2012 U.S. Department of Energy Office of Inspector General Office of Audits & Inspections Department of Energy Washington, DC 20585 November 29, 2012 MEMORANDUM FOR THE ADMINISTRATOR, SOUTHWESTERN POWER ADMINISTRATION FROM: Daniel M. Weeber Assistant Inspector General for Audits and Administration Office of Inspector General SUBJECT: INFORMATION: Audit Report on "Southwestern Federal Power System's Fiscal Year 2011 Financial Statement Audit" The attached report presents the results of the independent certified public accountants' audit of the Southwestern Federal Power System's (SWFPS) combined balance sheets, as of September 30,

64

NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function  

SciTech Connect

NF45/ILF2 associates with NF90/ILF3 in the nucleus and regulates IL-2 gene transcription at the antigen receptor response element (ARRE)/NF-AT DNA target sequence (P.N. Kao, L. Chen, G. Brock, J. Ng, A.J. Smith, B. Corthesy, J. Biol. Chem. 269 (1994) 20691-20699). NF45 is widely expressed in normal tissues, especially testis, brain, and kidney, with a predominantly nuclear distribution. NF45 mRNA expression is increased in lymphoma and leukemia cell lines. The human and murine NF45 proteins differ only by substitution of valine by isoleucine at amino acid 142. Fluorescence in situ hybridization localized the human NF45 gene to chromosome 1q21.3, and mouse NF45 gene to chromosome 3F1. Promoter analysis of 2.5 kB of the murine NF45 gene reveals that significant activation is conferred by factors, possible including NF-Y, that bind to the CCAAT-box sequence. The function of human NF45 in regulating IL-2 gene expression was characterized in Jurkat T-cells stably transfected with plasmids directing expression of NF45 cDNA in sense or antisense orientations. NF45 sense expression increased IL-2 luciferase reporter gene activity 120-fold, and IL-2 protein expression 2-fold compared to control cells. NF45 is a highly conserved, regulated transcriptional activator, and one target gene is IL-2.

Zhao Guohua [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States); Shi Lingfang [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States); Qiu Daoming [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States); Hu Hong [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States); Kao, Peter N. [Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305-5236 (United States)]. E-mail: peterkao@stanford.edu

2005-05-01T23:59:59.000Z

65

Transcriptional regulation of antimicrobial peptide induction by NF-[kappa]B family members during the Drosophila melanogaster immune response  

E-Print Network (OSTI)

Dl), a member of the NF-kB family, through degradation ofworks in conjunction with NF-kB members to regulate fat bodystandard deviation. (C). Role of fly NF-kB proteins in AttA

Busse, Matthew Schmidt

2007-01-01T23:59:59.000Z

66

Mathematical model of NF-kB regulatory module  

E-Print Network (OSTI)

The two-feedback-loop regulatory module of nuclear factor kB (NF-kB) signaling pathway is modeled by means of ordinary differential equations. The constructed model involves two-compartment kinetics of the activators IkB (IKK) and NF-kB; the inhibitors A20 and IkBa; and their complexes. In resting cells, the unphosphorylated IkBa binds to NF-kB and sequesters it in an inactive form in the cytoplasm. In response to extracellular signals such as tumor necrosis factor or interleukin-1, IKK is transformed from its neutral form (IKKn) into its active form (IKKa), a form capable of phosphorylating IkBa; leading to IkBa degradation. Degradation of IkBa releases the main activator NF-kB; which then enters the nucleus and triggers transcription of the inhibitors and numerous other genes. The newly synthesized IkBa leads NF-kB out of the nucleus and sequesters it in the cytoplasm, while A20 inhibits IKK converting IKKa into the inactive form (IKKi), a form different from IKKn, no longer capable of phosphorylating IkBa: After parameter fitting, the proposed model is able to properly reproduce time behavior of all variables for which the data are available: NF-kB; cytoplasmic IkBa; A20 and IkBa mRNA transcripts, IKK and IKK catalytic activity in both wild-type and A20-deficient cells. The model allows detailed analysis of kinetics of the involved proteins and their complexes and gives the predictions of the possible responses of whole kinetics to the change in the level of a given activator or inhibitor.

Tomasz Lipniacki A; Pawel Paszek B; Allan R. Brasier D; Bruce Luxon C; Marek Kimmel B

2003-01-01T23:59:59.000Z

67

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1  

E-Print Network (OSTI)

super family pathway and NF-kB pathway, such as TRADD, RELB,genes from wound healing and NF-kB signaling. Samples in the

Verhaak, Roel GW

2010-01-01T23:59:59.000Z

68

Audit Report: OAS-FS-12-10 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

2-10 2-10 Audit Report: OAS-FS-12-10 July 30, 2012 Southwestern Federal Power System's Fiscal Year 2010 Financial Statement Audit We contracted with the independent public accounting firm of KPMG, LLP (KPMG) to audit the combined balance sheets of the Southwestern Federal Power System (SWFPS) as of September 30, 2010 and 2009, and the related combined statements of revenues and expenses, changes in net Federal investment and cash flows for the years then ended. KPMG concluded that the combined financial statements present fairly, in all material respects, the respective financial position of SWFPS as of September 30, 2010 and 2009, and the results of its operations and its cash flow for the years then ended, in conformity with United States generally accepted accounting

69

Audit Report: OAS-FS-13-02 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

2 2 Audit Report: OAS-FS-13-02 September 7, 2012 Management Letter on the Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2011 Financial Statement Audit The Office of Inspector General (OIG) engaged the independent public accounting firm of KPMG, LLP (KPMG) to perform an audit of the United States Department of Energy's Uranium Enrichment Decontamination and Decommissioning (D&D) Fund's FY 2011 financial statements. KPMG concluded that the financial statements present fairly, in all material respects, the financial position of the D&D Fund as of September 30, 2011, and its net costs, changes in net position, and budgetary resources, in conformity with United States generally accepted accounting principles. As part of this review, the auditors also considered the D&D Fund's

70

Audit Report: OAS-FS-14-02 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

2 2 Audit Report: OAS-FS-14-02 Wednesday, December 11, 2013 Department of Energy's Nuclear Waste Fund's Fiscal Year 2013 Financial Statement Audit The Office of Inspector General contracted with the independent public accounting firm of KPMG, LLP (KPMG) to conduct an audit of the Department of Energy's Nuclear Waste Fund's Fiscal Year 2013 balance sheet and the related statements of net cost, changes in net position and combined statements of budgetary resources. KPMG concluded that the financial statements present fairly, in all material respects, the financial position of the Fund as of September 30, 2013 and 2012, and its net costs, changes in net position, and budgetary resources for the years then ended, in conformity with United States generally accepted accounting principles.

71

Department of Energy's Fiscal Year 2012 Consolidated Financial Statement, OAS-FS-13-04  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

2 Consolidated Financial 2 Consolidated Financial Statements OAS-FS-13-04 November 2012 U.S. Department of Energy Office of Inspector General Office of Audits & Inspections Department of Energy Washington, DC 20585 November 15, 2012 MEMORANDUM FOR THE SECRETARY FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Report on the Department of Energy's Fiscal Year 2012 Consolidated Financial Statements Pursuant to requirements established by the Government Management Reform Act of 1994, the Office of Inspector General (OIG) engaged the independent public accounting firm of KPMG, LLP (KPMG) to perform the audit of the Department of Energy's (Department) Fiscal Year 2012 Consolidated Financial Statements. KPMG audited the Department's consolidated balance sheets as of September 30, 2012 and

72

Audit Report: OAS-FS-13-04 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

4 4 Audit Report: OAS-FS-13-04 November 15, 2012 Department of Energy's Fiscal Year 2012 Consolidated Financial Statement KPMG, LLP (KPMG) audited the consolidated balance sheets of the Department of Energy (Department) as of September 30, 2012 and 2011, and the related consolidated statements of net cost, changes in net position, and custodial activity, and combined statement of budgetary resources, for the years then ended. KPMG concluded that these consolidated financial statements are presented fairly, in all material respects, in conformity with U.S. generally accepted accounting principles and has issued an unqualified opinion based on its audits and the reports of other auditors for the years ended September 30, 2012 and 2011. As part of this review, auditors also considered the Department's internal

73

Audit Report: OAS-FS-12-08 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

8 8 Audit Report: OAS-FS-12-08 March 28, 2012 Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2009 Balance Sheet Audit We contracted with the independent public accounting firm of KPMG, LLP (KPMG) to express an opinion on the Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2009 Balance Sheet. KPMG concluded that, except for insufficient evidence to support inventories held for sale and undelivered orders, the latter of which effects the classifications of fund balance with Treasury, the Isotope Program's balance sheet as of September 30, 2009, is presented fairly, in all material respects, in conformity with U.S. generally accepted accounting principles. The auditors' consideration of internal

74

Southwestern Federal Power System's Fiscal Year 2010 Financial Statement Audit, OAS-FS-12-10  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

10 Financial 10 Financial Statement Audit OAS-FS-12-10 July 2012 Department of Energy Washington, DC 20585 July 30, 2012 MEMORANDUM FOR THE ADMINISTRATOR, SOUTHWESTERN POWER ADMINISTRATION FROM: Daniel M. Weeber Assistant Inspector General for Audits and Administration Office of Inspector General SUBJECT: INFORMATION: Southwestern Federal Power System's Fiscal Year 2010 Financial Statement Audit The attached report present the results of the independent certified public accountants' audit of the Southwestern Federal Power System's (SWFPS) combined balance sheets, as of September 30, 2010 and 2009, and the related combined statements of revenues and expenses, changes in net Federal investment and cash flows. To fulfill the Office of Inspector General's (OIG) audit responsibilities, we contracted with the

75

Department of Energy's Fiscal Year 2011 Consolidated Financial Statements,OAS-FS-12-02  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Department of Energy's Fiscal Year Department of Energy's Fiscal Year 2011 Consolidated Financial Statements OAS-FS-12-02 November 2011 Department of Energy Washington, DC 20585 November 15, 2011 MEMORANDUM FOR~ FROM: Gregory H. Fn~dman ~ Inspector General SUBJECT: INFORMATION: Report on the Department ofEnergy's Fiscal Year 2011 Consolidated Financial Statements Pursuant to requirements established by the Government Management Reform Act of 1994, the Office of Inspector General engaged the independent public accounting firm ofKPMG LLP (KPMG) to perform the audit of the Department of Energy's (Department) Fiscal Year (FY) 2011 Consolidated Financial Statements. KPMG audited the consolidated balance sheets of the Department as of September 30, 2011 and

76

Audit Report: OAS-FS-13-06 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

6 6 Audit Report: OAS-FS-13-06 November 29, 2012 Southwestern Federal Power System's Fiscal Year 2011 Financial Statement Audit We contracted with the independent public accounting firm of KPMG LLP to audit the combined balance sheets of the Southwestern Federal Power System (SWFPS) as of September 30, 2011 and 2010, and the related combined statements of changes in capitalization, revenues and expenses, and cash flows for the years then ended. KPMG concluded that the combined financial statements present fairly, in all material respects, the respective financial position of the Southwestern Federal Power System as of September 30, 2011 and 2010, and the results of its operations and its cash flow for the years then ended, in conformity with United States

77

Audit Report: OAS-FS-13-08 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

8 8 Audit Report: OAS-FS-13-08 December 17, 2012 Management Letter on the Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 2012 KPMG, LLP noted certain matters involving internal control and other operational matters during their audit of the Department of Energy's (Department) Consolidated Financial Statements for Fiscal Year (FY) 2012. These matters are intended to improve the Department's internal controls or result in other operational efficiencies. The management letter contains 16 new findings and 7 repeat findings that were issued during the course of the FY 2012 Audit of the Department's Consolidated Financial Statements. Management generally concurred with and provided planned corrective actions for most of the recommendations

78

Audit Report: OAS-FS-13-03 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

3 3 Audit Report: OAS-FS-13-03 November 15, 2012 The Federal Energy Regulatory Commission's Fiscal Year 2012 Financial Statement Audit KPMG, LLP concluded that the financial statements present fairly, in all material respects, the financial position of the Federal Energy Regulatory Commission (Commission) as of September 30, 2012, and its net costs, changes in net position, budgetary resources, and custodial activity for the years then ended, in conformity with United States generally accepted accounting principles. The auditors' review of the Commission's internal control structure and compliance with certain laws and regulations disclosed no material weaknesses or instances of noncompliance required to be reported under generally accepted Government auditing standards or applicable Office of

79

Audit Report: OAS-FS-12-07 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

7 7 Audit Report: OAS-FS-12-07 March 15, 2012 Performance Audit of the Department of Energy's Improper Payment Reporting in the Fiscal Year 2011 Agency Financial Report To fulfill the Office of Inspector General's Audit Responsibilities we contracted with the independent public accounting firm of KPMG, LLP to express an opinion on whether the Department of Energy (Department) met the Office of Management and Budget's criteria for compliance with the Improper Payments Elimination and Recovery Act (IPERA). The objective of this audit was to complete an evaluation of the accuracy and completeness of agency reporting, and evaluate agency performance in reducing and recapturing improper payments under IPERA. This audit found that the Department did not comply with the requirements of IPERA pertaining to site

80

Audit Report: OAS-FS-12-02 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

2 2 Audit Report: OAS-FS-12-02 November 15, 2011 Department of Energy's Fiscal Year 2011 Consolidated Financial Statements KPMG audited the consolidated balance sheets of the Department of Energy (Department) as of September 30, 2011 and 2010, and the related consolidated statements of net cost, changes in net position, and custodial activity, and combined statement of budgetary resources, for the years then ended. KPMG concluded that these consolidated financial statements are presented fairly, in all material respects, in conformity with U.S. generally accepted accounting principles and has issued an unqualified opinion based on its audits and the reports of other auditors for the year ended September 30, 2011. As part of this review, auditors also considered the Department's internal

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Audit Report: OAS-FS-13-12 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

2 2 Audit Report: OAS-FS-13-12 March 14, 2013 Performance Audit of the Department of Energy's Improper Payment Reporting in the Fiscal Year 2012 Agency Financial Report We contracted with an independent public accounting firm, KPMG LLP, to express an opinion on whether the Department of Energy (Department) met the Office of Management and Budget's criteria for compliance with the Improper Payments Elimination and Recovery Act (IPERA). The objective of this audit was to complete an evaluation of the accuracy and completeness of agency reporting, and evaluate agency performance in reducing and recapturing improper payments under IPERA. This audit found that the Department complied with the requirements of IPERA. Furthermore, KPMG noted two observations for improvement regarding the Department's improper

82

Audit Report: OAS-FS-11-05 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

5 5 Audit Report: OAS-FS-11-05 December 20, 2010 Management Letter on the Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 2010 Attached is the subject letter prepared by KPMG LLP, our contract auditors. The letter contains 23 new findings (see letter, Exhibit A) and 4 repeat findings (see letter, Exhibit B) that were issued during the course of the Fiscal Year 2010 audit of the Department of Energy's (Department) Consolidated Financial Statements. Management generally concurred with and provided planned corrective actions for most of the recommendations listed in the Management Letter and management's comments are included in each finding. No Departmental position is required for the findings in this report. However, the recommendations are open and should be tracked in the

83

Audit Report: OAS-FS-14-01 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

4-01 4-01 Audit Report: OAS-FS-14-01 November 25, 2013 Federal Energy Regulatory Commission's Fiscal Year 2013 Financial Statement Audit The Office of Inspector General contracted with the independent public accounting firm of KPMG, LLP (KPMG) to conduct the audit, subject to our review. KPMG is responsible for expressing an opinion on the Commission's financial statements and reporting on applicable internal controls and compliance with laws and regulations. The Office of Inspector General monitored audit progress and reviewed the audit report and related documentation. KPMG concluded that the financial statements present fairly, in all material respects, the financial position of the Commission as of and for the years ended September 30, 2013 and 2012, and its net costs, changes in

84

Audit Report: OAS-FS-13-05 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

5 5 Audit Report: OAS-FS-13-05 November 28, 2012 Department of Energy's Nuclear Waste Fund's Fiscal Year 2012 Financial Statement Audit KPMG, LLP (KPMG) audited the Department of Energy's Nuclear Waste Fund's (Fund) Fiscal Year 2012 balance sheet and the related statements of net cost, changes in net position and budgetary resources. KPMG concluded that the financial statements present fairly, in all material respects, the financial position of the Fund as of September 30, 2012 and 2011, and its net costs, changes in net position, and budgetary resources for the years then ended, in conformity with United States generally accepted accounting principles. The auditors' review of the Fund's internal control structure and compliance with certain laws and regulations disclosed no material

85

Audit Report: OAS-FS-10-02 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

2 2 Audit Report: OAS-FS-10-02 November 12, 2009 Report on "The Department of Energy's FiscalYear 2009 Consolidated Financial Statements" This is to inform you that the Department of Energy's (Department) Consolidated Financial Statements for Fiscal Year (FY) 2009 have received an unqualified opinion. Pursuant to requirements established by the Government Management Reform Act of 1994, the Office of Inspector General (OIG) engaged the independent public accounting firm of KPMG LLP (KPMG) to perform an audit of the Department's FY 2009 Consolidated Financial Statements. The audit was performed in accordance with auditing standards generally accepted in the United States of America; the standards applicable to financial audits contained in the Government Auditing

86

Stress Analysis of Floor Slab from Hyster 550 FS Lift Truck with 55 Kip Pay Load  

Science Conference Proceedings (OSTI)

The objective of this calculation is to determine the probable moments and stresses that will be induced into the slab on grade floor at building 2404WA from operation of a Hyster 550 FS lift truck having tire pressures of 124 psi while moving and placing SWDB boxes within building 2404WA. It was found that the probable reinforcing steel stress induced in the grade 60 reinforcing steel for the 124 psi tire pressure is about 35.55 ksi and the factor of safety against yield is about 1.7:l. The probable maximum concrete compression stress is expected to be about 2.21 ksi resulting in a factor of safety of about 2.04:1 against concrete compression failure. Slab on grade design is not subject to building code factors of safety requirements.

BLACK, D.G.

2003-06-05T23:59:59.000Z

87

Audit Report: OAS-FS-12-03 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

3 3 Audit Report: OAS-FS-12-03 November 2, 2011 The Department of Energy's Nuclear Waste Fund's Fiscal Year 2011 Financial Statements The attached report presents the results of the independent certified public accountants' audit of the Department of Energy's Nuclear Waste Fund's (Fund) Fiscal Year 2011 balance sheet and the related statements of net cost, changes in net position, and budgetary resources.To fulfill the Office of Inspector General's audit responsibilities, we contracted with the independent public accounting firm of KPMG LLP (KPMG) to conduct the audit, subject to our review. KPMG is responsible for expressing an opinion on the Fund's financial statements and reporting on applicable internal controls and compliance with laws and regulations. The Office of Inspector

88

Audit Report: OAS-FS-13-13 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

3-13 3-13 Audit Report: OAS-FS-13-13 August 12, 2013 Southwestern Federal Power System's Fiscal Year 2012 Financial Statement Audit We contracted with the independent public accounting firm of KPMG LLP (KPMG) to conduct the audit the Southwestern Federal Power System's (SWFPS) financial statements and reporting on applicable internal controls and compliance with laws and regulations. KPMG concluded that the combined financial statements present fairly, in all material respects, the respective financial position of the SWFPS as of September 30, 2012 and 2011, and the results of its operations and its cash flow for the years then ended, in conformity with U.S. generally accepted accounting principles. The audit identified an internal control deficiency over Accounting for

89

Physiological functions for brain NF-kB Mollie K. Meffert and David Baltimore  

E-Print Network (OSTI)

Physiological functions for brain NF-kB Mollie K. Meffert and David Baltimore Division of BiologyB (NF-kB) family of transcription factors are activated within the CNS in pathological settings of the mechanisms of Ca2C -responsive activation and synaptic signaling to the nucleus by NF-kB transcription

Baltimore, David

90

Single-cell NF-kB dynamics reveal digital activation and analogue information processing  

E-Print Network (OSTI)

LETTERS Single-cell NF-kB dynamics reveal digital activation and analogue information processing information to the gene expression programs by means of the transcription factor nuclear factor (NF)-kB. We measured NF-kB activity in thousands of live cells under TNF-a doses covering four orders of magnitude. We

Quake, Stephen R.

91

ORIGINAL ARTICLE NF-jB activation by combinations of NEMO SUMOylation and ATM  

E-Print Network (OSTI)

The Rel/NF-kB family of transcription factors has been intensively studied as an important paradigm expression profiles (reviewed in Hayden and Ghosh (2004)). The proto- typical mammalian NF-kB complex, a p50 necrosis factor (TNF), interleukin-1 and bacterial lipopolysaccharide (LPS), activate NF-kB via convergence

Miyamoto, Shigeki

92

Dual Delayed Feedback Provides Sensitivity and Robustness to the NF-kB Signaling Module  

E-Print Network (OSTI)

Dual Delayed Feedback Provides Sensitivity and Robustness to the NF-kB Signaling Module Diane M of the transcription factor NF-kB. Linear stability analysis of the model shows that oscillatory frequency is a hard system minimizes stochastic excursions of the output to produce a robust NF-kB response. Citation: Longo

Hasty, Jeff

93

NF-[kappa]B RelB/p52 heterodimer : biogenesis and DNA recognition  

E-Print Network (OSTI)

A fourth IkB protein in the NF-kB signaling module. Cell, InCD28 is mediated through an NF-kB-like response element. JTo further test how other NF-kB dimers interact with CREB,

Fusco, Amanda J.

2007-01-01T23:59:59.000Z

94

Crack Width Analysis of Floor Slabs from Hyster 550 FS Lift Truck with 55 Kip Pay Load  

Science Conference Proceedings (OSTI)

This calculation determines the probable crack width experienced by the slab on grade floor at Building 2404WA from a Hyster 550 FS lift truck having tire pressures of 124 psi while moving and placing Standard Waste Disposal Boxes within the building.

BLACK, D.G.

2003-06-05T23:59:59.000Z

95

Radiometric and Engineering Performance of the SeaWiFS Quality Monitor (SQM): A Portable Light Source for Field Radiometers  

Science Conference Proceedings (OSTI)

A portable and stable source of radiant flux, the Sea-viewing Wide Field-of-view Sensor (SeaWiFS) Quality Monitor (SQM), was developed as a field instrument for use in experiments away from the calibration laboratory such as those encountered ...

B. Carol Johnson; Ping-Shine Shaw; Stanford B. Hooker; Don Lynch

1998-08-01T23:59:59.000Z

96

Vol. 2003, Issue 36, pp. nf17, 10 September 2003 [DOI: 10.1126/sageke.2003.36.nf17  

E-Print Network (OSTI)

Document URL: http://sageke.sciencemag.org/cgi/content/full/sageke;2003/36/nf17 Science , . This article sophomore year in 1987. "It was actually a science experiment gone awry," confesses Gazzaley with a giggle into the toilet bowl. But he had miscalculated the power of the reaction: The resulting explosion shook

97

b-Arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-jB  

E-Print Network (OSTI)

: b-arrestin2; CK2; NF-kB Introduction The UV response in mammalian cells is mediated through activation of several transcription factors, including NF-kB (Shaulian et al, 2000). In resting cells, NF-kB by Silverman and Maniatis, 2001). The binding of IkB to NF-kB masks the nuclear localization sequences (NLS

Tian, Weidong

98

COMMD1 promotes the ubiquitination of NF-jB subunits through a cullin-containing ubiquitin  

E-Print Network (OSTI)

& transcription; proteins Keywords: COMMD1; cullin; NF-kB; transcription; ubiquitination Introduction NF-kB im- munity, apoptosis, and cell cycle progression (Karin and Lin, 2002). In mammals, NF-kB subunits into the mature p50 and p52 subunits, respectively. NF-kB is ordinarily sequestered in the cytoplasm

Burstein, Ezra

99

NF-kB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1a  

E-Print Network (OSTI)

LETTERS NF-kB links innate immunity to the hypoxic response through transcriptional regulation, regulated by several transcription factors, among which NF-kB plays a central role5,6 . NF-kB activation between NF-kB and HIF-1a has proven elusive. Using in vitro systems, it was reported that HIF-1a activates

Nizet, Victor

100

Observation of excited state charge transfer with fs/ps-CARS  

Science Conference Proceedings (OSTI)

Excited state charge transfer processes are studied using the fs/ps-CARS probe technique. This probe allows for multiplexed detection of Raman active vibrational modes. Systems studied include Michler's Ketone, Coumarin 120, 4-dimethylamino-4{prime}-nitrostilbene, and several others. The vibrational spectrum of the para di-substituted benzophenone Michler's Ketone in the first excited singlet state is studied for the first time. It is found that there are several vibrational modes indicative of structural changes of the excited molecule. A combined experimental and theoretical approach is used to study the simplest 7-amino-4-methylcoumarin, Coumarin 120. Vibrations observed in FTIR and spontaneous Raman spectra are assigned using density functional calculations and a continuum solvation model is used to predict how observed modes are affected upon inclusion of a solvent. The low frequency modes of the excited state charge transfer species 4-dimethylamino-4{prime}-nitrostilbene are studied in acetonitrile. Results are compared to previous work on this molecule in the fingerprint region. Finally, several partially completed projects and their implications are discussed. These include the two photon absorption of Coumarin 120, nanoconfinement in cyclodextrin cavities and sensitization of titania nanoparticles.

Blom, Alex Jason

2009-08-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Low Dose Radiation Research Program: Regulation of NF-kB and MnSOD in Low  

NLE Websites -- All DOE Office Websites (Extended Search)

NF-kB and MnSOD in Low Dose Radiation-Induced Adaptive NF-kB and MnSOD in Low Dose Radiation-Induced Adaptive Responses in Mouse and Human Skin Cells Jian Jian Li School of Health Sciences, Purdue University West Lafayette, Indiana Why this Project? To determine if low dose ionizing radiation-induced adaptive responses in skin cells are mediated by activation of signaling networks. Project Goals To evaluate the signaling networks involving transcription factor NF-kB and the mitochondrial antioxidant protein MnSOD. To determine if NF-kB is activated by low dose radiation in vivo. To determine if NF-kB activation is critical in the pathways that produce adaptive responses. Experimental Approach Cells transfected with NF-kB luciferase responder genes will be used to define a dose-response relationship for activation of the NF-kB gene. NF-kB

102

The Federal Energy Regulatory Commission's Fiscal Year 2012 Financial Statement Audit, OAS-FS-13-03  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Federal Energy Regulatory Federal Energy Regulatory Commission's Fiscal Year 2012 Financial Statement Audit OAS-FS-13-03 November 2012 Department of Energy Washington, DC 20585 November 15, 2012 MEMORANDUM FOR THE CHAIRMAN, FEDERAL ENERGY REGULATORY COMMISSION FROM: Rickey R. Hass Deputy Inspector General for Audits and Inspections Office of Inspector General SUBJECT: INFORMATION: Federal Energy Regulatory Commission's Fiscal Year 2012 Financial Statement Audit The attached report presents the results of the independent certified public accountants' audit of the Federal Energy Regulatory Commission's (Commission) balance sheets as of September 30, 2012 and 2011, and the related statements of net costs, changes in net position, budgetary

103

The Federal Energy Regulatory Commission's Fiscal Year 2011 Financial Statement Audit, OAS-FS-12-01  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

1 1 Financial Statement Audit OAS-FS-12-01 November 2011 Department of Energy Washington, DC 20585 November 15, 2011 MEMORANDUM FOR THE CHAIRMAN, FEDERAL ENERGY REGULATORY COMMISSION FROM: Rickey R. Hass Deputy Inspector General for Audits and Inspections Office of Inspector General SUBJECT: INFORMATION: Federal Energy Regulatory Commission's Fiscal Year 2011 Financial Statement Audit The attached report presents the results of the independent certified public accountants' audit of the Federal Energy Regulatory Commission (Commission) Fiscal Year 2011 balance sheet and the related statements of net cost, changes in net position, budgetary resources, and custodial activity.

104

The IkBa/NF-kB complex has two hot spots, one at either end of the interface  

E-Print Network (OSTI)

The IkBa/NF-kB complex has two hot spots, one at either end of the interface SIMON BERGQVIST,1 of NF-kB family members via its ankyrin repeat (AR) domain. The binding affinity of IkBa with NF-kB(p50/p65) heterodimers and NF-kB(p65/65) homodimers is in the picomolar range, and in the cell

Komives, Elizabeth A.

105

Myelin Activates FAK/Akt/NF-kB Pathways and Provokes CR3-Dependent Inflammatory Response in Murine  

E-Print Network (OSTI)

Myelin Activates FAK/Akt/NF-kB Pathways and Provokes CR3-Dependent Inflammatory Response in Murine is through activation of FAK/PI3K/Akt/NF-kB signaling pathways and CR3 contributes to myelin-induced PI3K/Akt/NF-kB) are not able to activate NF-kB signaling pathway. In conclusion, our results demonstrate a crucial role

Fan, Jianqing

106

An Epigenetic Switch Involving NF-kB, Lin28, Let-7 MicroRNA, and IL6 Links  

E-Print Network (OSTI)

An Epigenetic Switch Involving NF-kB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell to cancer, and NF-kB appears to play a causa- tive role, but the mechanisms are poorly understood. We show activation triggers an inflammatory response mediated by NF-kB that directly activates Lin28 transcription

107

NMR studies of the transcriptional inhibitor I kappa B alpha and its interaction with the transcription factor NF kappa B  

E-Print Network (OSTI)

E. A. (2008) The IkBa/NF-kB complex has two hot-spots, oneThe genes regulated by NF-kB fall into various functionaldimerization domains and NF-kB p65 amino-terminal domain (

Cervantes, Carla F.

2010-01-01T23:59:59.000Z

108

Dying for NF-jB? Control of cell death by transcriptional regulation of the apoptotic machinery  

E-Print Network (OSTI)

Ezra Burstein and Colin S Duckett? The transcription factor nuclear factor kB (NF-kB) is a pleiotropic signals and cellular stress. Several hundred cellular genes have been shown to be regulated by NF-kB showed that loss or suppression of NF-kB results in an enhanced sensitivity to apoptosis. In the ensuing

Burstein, Ezra

109

WntD is a feedback inhibitor of Dorsal/NF-kB in Drosophila development and immunity  

E-Print Network (OSTI)

WntD is a feedback inhibitor of Dorsal/NF-kB in Drosophila development and immunity Michael D. Gordon1 , Marc S. Dionne2 , David S. Schneider2 & Roel Nusse1 Regulating the nuclear factor-kB (NF-kB melanogaster have proved fruitful in determining the signals used to control NF-kB proteins, beginning

Bejerano, Gill

110

NF-{kappa}B regulates Lef1 gene expression in chondrocytes  

SciTech Connect

The relation of Wnt/{beta}-catenin signaling to osteoarthritis progression has been revealed with little information on the underlying molecular mechanism. In this study we found overexpression of Lef1 in cartilage tissue of osteoarthritic patients and elucidated molecular mechanism of NF-{kappa}B-mediated Lef1 gene regulation in chondrocytes. Treatment of IL-1{beta} augmented Lef1 upregulation and nuclear translocation of NF-{kappa}B in chondrocytes. Under IL-1{beta} signaling, treatment of NF-{kappa}B nuclear translocation inhibitor SN-50 reduced Lef1 expression. A conserved NF-{kappa}B-binding site between mouse and human was selected through bioinformatic analysis and mapped at the 14 kb upstream of Lef1 transcription initiation site. NF-{kappa}B binding to the site was confirmed by chromatin immunoprecipitation assay. Lef1 expression was synergistically upregulated by interactions of NF-{kappa}B with Lef1/{beta}-catenin in chondrocytes. Our results suggest a pivotal role of NF-{kappa}B in Lef1 expression in arthritic chondrocytes or cartilage degeneration.

Yun, Kangsun [Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712 (Korea, Republic of); Choi, Yoo Duk [Department of Pathology, Chonnam National University Medical School, Gwangju 501-749 (Korea, Republic of); Nam, Jong Hee [Department of Pathology, Chonnam National University Medical School, Gwangju 501-749 (Korea, Republic of); Park, Zeeyoung [Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712 (Korea, Republic of); Im, Sin-Hyeog [Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712 (Korea, Republic of)]. E-mail: imsh@gist.ac.kr

2007-06-08T23:59:59.000Z

111

La activacin de NF-kB, indicador de recada en el cncer de mama  

E-Print Network (OSTI)

La activación de NF-kB, indicador de recaída en el cáncer de mama La ausencia de la proteína 14 proteico relacio- nado con la progresión tumoral, NF-kB, según apunta un estudio en PLoS ONE realiza- do activación de NF-kB en los tumores como el mejor indi- cador de recaída en las pa- cientes de cáncer de mama

Foissac, Sylvain

112

RELAP5/MOD3 assessment using the Semiscale 50% Feed Line Break test S-FS-11  

SciTech Connect

The RELAP5/MOD3 5m5 code was assessed using the 1/1705 volume scaled Semiscale 50% Feed Line Break (FLB) test S-FS-11. Test S-FS-11 was designed in three phases: (a) blowdown phase, (b) stabilization phase, and (c) refill phase. The first objective was to assess the code applicability to 50% FLB situation, the second was to evaluate the FSAR conservatisms regarding SG heat transfer degradation, steam line check valve failure, break flow state, and peak primary system pressure, and the third was to validate the EOP effectiveness. The code was able to simulate the major T/H parameters except for the two-phase break flow and the secondary convective heat transfer rate. The two-phase break flow had still deficiencies. The current boiling heat transfer rate was developed from the data for flow inside of a heated tube, not for flow around heated tubes in a tube bundle. Results indicated that the assumption of 100% heat transfer until the liquid inventory depletion was not conservative, the failed affected steam generator main steam line check valve assumption was not either conservative, the measured break flow experienced all types of flow conditions, the relative proximity to the 110% design pressure limit was conservative. The automatic actions during the blowdown phase were effective in mitigating the consequences. The stabilization operation performed by operator actions were effective to permit natural circulation cooldown and depressurization. The voided secondary refill operations also verified the effectiveness of the operations while recovering the inventory in a voided steam generator.

Lee, E.J.; Chung, B.D.; Kim, H.J. [Korea Inst. of Nuclear Safety, Taejon (Korea, Republic of)

1993-06-01T23:59:59.000Z

113

Optineurin Is Required for CYLD-Dependent Inhibition of TNFa-Induced NF-kB Activation  

E-Print Network (OSTI)

The nuclear factor kappa B (NF-kB) regulates genes that function in diverse cellular processes like inflammation, immunity and cell survival. The activation of NF-kB is tightly controlled and the deubiquitinase CYLD has emerged as a key negative regulator of NF-kB signalling. Optineurin, mutated in certain glaucomas and amyotrophic lateral sclerosis, is also a negative regulator of NF-kB activation. It competes with NEMO (NF-kB essential modulator) for binding to ubiquitinated RIP (receptor interacting protein) to prevent NF-kB activation. Recently we identified CYLD as optineurin-interacting protein. Here we have analysed the functional significance of interaction of optineurin with CYLD. Our results show that a glaucomaassociated mutant of optineurin, H486R, is altered in its interaction with CYLD. Unlike wild-type optineurin, the H486R mutant did not inhibit tumour necrosis factor a (TNFa)-induced NF-kB activation. CYLD mediated inhibition of TNFainduced NF-kB activation was abrogated by expression of the H486R mutant. Upon knockdown of optineurin, CYLD was unable to inhibit TNFa-induced NF-kB activation and showed drastically reduced interaction with ubiquitinated RIP. The level of ubiquitinated RIP was increased in optineurin knockdown cells. Deubiquitination of RIP by over-expressed CYLD was abrogated in optineurin knockdown cells. These results suggest that optineurin regulates NF-kB activation by mediating

Ananthamurthy Nagabhushana; Megha Bansal; Ghanshyam Swarup

2010-01-01T23:59:59.000Z

114

Imaging Pulmonary NF-kappaB Activation and Therapeutic Effects of MLN120B and TDZD-8  

E-Print Network (OSTI)

NF-kB activation is a critical signaling event in the inflammatory response and has been implicated in a number of pathological lung diseases. To enable the assessment of NF-kB activity in the lungs, we transfected a luciferase based NF-kB reporter into the lungs of mice or into Raw264.7 cells in culture. The transfected mice showed specific luciferase expression in the pulmonary tissues. Using these mouse models, we studied the kinetics of NF-kB activation following exposure to lipopolysaccharide (LPS). The Raw264.7 cells expressed a dose-dependent increase in luciferase following exposure to LPS and the NF-kB reporter mice expressed luciferase in the lungs following LPS challenge, establishing that bioluminescence imaging provides adequate sensitivity for tracking the NF-kB activation pathway. Interventions affecting the NF-kB pathway are promising clinical therapeutics, thus we further examined the effect of IKK-2 inhibition by MLN120B and glycogen synthase kinase 3 beta inhibition by TDZD-8 on NF-kB activation. Pre-treatment with either MLN120B or TDZD-8 attenuated NF-kB activation in the pulmonary tissues, which was accompanied with suppression of pro-inflammatory chemokine MIP-1 and induction of anti-inflammatory cytokine IL-10. In summary, we have established an imaging based approach for noninvasive and longitudinal assessment of NF-kB activation and regulation during acute lung injury. This approach will

Dan Ansaldi; Eldad A. Hod; Fabio Stellari; Jae-beom Kim; Mark Roskey; Kevin P. Francis; Rajendra Singh; Ning Zhang

2011-01-01T23:59:59.000Z

115

Polycystin-1 promotes PKC{alpha}-mediated NF-{kappa}B activation in kidney cells  

Science Conference Proceedings (OSTI)

Polycystin-1 (PC1), the PKD1 gene product, is a membrane receptor which regulates many cell functions, including cell proliferation and apoptosis, both typically increased in cyst lining cells in autosomal dominant polycystic kidney disease. Here we show that PC1 upregulates the NF-{kappa}B signalling pathway in kidney cells to prevent cell death. Human embryonic kidney cell lines (HEK293{sup CTT}), stably expressing a PC1 cytoplasmic terminal tail (CTT), presented increased NF-{kappa}B nuclear levels and NF-{kappa}B-mediated luciferase promoter activity. This, consistently, was reduced in HEK293 cells in which the endogenous PC1 was depleted by RNA interference. CTT-dependent NF-{kappa}B promoter activation was mediated by PKC{alpha} because it was blocked by its specific inhibitor Ro-320432. Furthermore, it was observed that apoptosis, which was increased in PC1-depleted cells, was reduced in HEK293{sup CTT} cells and in porcine kidney LtTA cells expressing a doxycycline-regulated CTT. Staurosporine, a PKC inhibitor, and parthenolide, a NF-{kappa}B inhibitor, significantly reduced the CTT-dependent antiapoptotic effect. These data reveal, therefore, a novel pathway by which polycystin-1 activates a PKC{alpha}-mediated NF-{kappa}B signalling and cell survival.

Banzi, Manuela [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy); Aguiari, Gianluca [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy); Trimi, Viky [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy); Mangolini, Alessandra [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy); Pinton, Paolo [General Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara (Italy); Witzgall, Ralph [Institute for Molecular and Cellular Anatomy, University of Regensburg, Regensburg (Germany); Rizzuto, Rosario [General Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara (Italy); Senno, Laura del [Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara (Italy)]. E-mail: sen@unife.it

2006-11-17T23:59:59.000Z

116

MicroRNAs Modulate the Dynamics of the NF-kB Signaling Pathway  

E-Print Network (OSTI)

Background: NF-kB, a major transcription factor involved in mammalian inflammatory signaling, is primarily involved in regulation of response to inflammatory cytokines and pathogens. Its levels are tightly regulated since uncontrolled inflammatory response can cause serious diseases. Mathematical models have been useful in revealing the underlying mechanisms, the dynamics, and other aspects of regulation in NF-kB signaling. The recognition that miRNAs are important regulators of gene expression, and that a number of miRNAs target different components of the NF-kB network, motivate the incorporation of miRNA regulated steps in existing mathematical models to help understand the quantitative aspects of miRNA mediated regulation. Methodology/Principal findings: In this study, two separate scenarios of miRNA regulation within an existing model are considered. In the first, miRNAs target adaptor proteins involved in the synthesis of IKK that serves as the NF-kB activator. In the second, miRNAs target different isoforms of IkB that act as NF-kB inhibitors. Simulations are carried out under two different conditions: when all three isoforms of IkB are present (wild type), and when only one isoform (IkBa) is present (knockout type). In both scenarios, oscillations in the NF-kB levels are observed and are found to be dependent on the levels of miRNAs. Conclusions/Significance: Computational modeling can provide fresh insights into intricate regulatory processes. The

Ida Vaz; Arvind Singh Mer; Alok Bhattacharya; Ramakrishna Ramaswamy

2011-01-01T23:59:59.000Z

117

A test of first order scaling in Nf=2 QCD  

E-Print Network (OSTI)

We complete our analysis of Nf=2 QCD based on the lattice staggered fermion formulation. Using a series of Monte Carlo simulations at fixed (amq*Ls^yh) one is able to test the universality class with given critical exponent yh. This strategy has been used to test the O(4) universality class and it has been presented at the previous Lattice conferences. No agreement was found with simulations in the mass range amq=[0.01335,0.15] using lattices with Ls=16 up to 32 and Lt=4. With the same strategy, we now investigate the possibility of a first order transition using a new set of Monte Carlo data corresponding to yh=3 in the same mass and volume range as the one used for O(4). A substantial agreement is observed both in the specific heat scaling and in the scaling of the chiral condensate, while the chiral susceptibilities still presents visible deviation from scaling in the mass range explored.

G. Cossu; M. D'Elia; A. Di Giacomo; C. Pica

2007-09-30T23:59:59.000Z

118

The role of the phosphorus BIBII transition in proteinDNA recognition: the NF-kB complex  

E-Print Network (OSTI)

The role of the phosphorus BI±BII transition in protein±DNA recognition: the NF-kB complex K) containing the HIV-1 NF-kB-binding site, in which the sequences ¯anking the kB site had been mutated. 31P NMR of the BI±BII equilibrium in NF-kB recognition by DNA was then investigated by electrophoretic mobility

Paris-Sud XI, Université de

119

Regenerative amplification of femtosecond pulses: Design and construction of a sub-100fs, {mu}J laser system  

Science Conference Proceedings (OSTI)

Femtosecond lasers are a powerful tool for a wealth of applications in physics, chemistry and biology. In most cases, however, their use is fundamentally restricted to a rather narrow spectral range. This thesis deals with the construction and characterization of a femtosecond light source for spectroscopic applications which overcomes that restriction. It is demonstrated how the output of a continuously pumped Ti:sapphire femtosecond oscillator is amplified to the {mu}J level, while the pulse duration remains below 100fs. A combination of continuous pumping, acousto-optic switching and Ti:Al{sub 2}O{sub 3} as a gain medium allows amplification at high repetition rates. By focusing the high energy pulses into a sapphire crystal, a broad-band continuum can be generated, extended in wavelengths over several hundred nanometers. To accomplish amplification of three orders of magnitude while maintaining the pulse length, a regenerative multipass amplifier system was built. The thesis describes theoretical design, realization and characterization of the system. Theoretical calculations and preliminary measurements were carried out and allow a critical evaluation of the final performance.

Schumacher, A.B. [Universitaet Karlsruhe (Germany). Institut fuer Angewandte Physik]|[Lawrence Berkeley National Lab., CA (United States)

1996-10-01T23:59:59.000Z

120

Regenerative Amplification of Femtosecond Pulses: Design andConstruction of a sub-100fs, muon J Laser System  

Science Conference Proceedings (OSTI)

Femtosecond lasers are a powerful tool for a wealth of applications in physics, chemistry and biology. In most cases, however, their use is fundamentally restricted to a rather narrow spectral range. This thesis deals with the construction and characterization of a femtosecond light source for spectroscopic applications which overcomes that restriction. It is demonstrated how the output of a continuously pumped Ti:sapphire femtosecond oscillator is amplified to the {mu}J level,while the pulse duration remains below 100 fs. A combination of continuous pumping, acousto-optic switching and Ti:Al{sub 2}O{sub 3} as a gain medium allows amplification at high repetition rates. By focusing the high energy pulses into a sapphire crystal, a broad-band continuum can be generated, extended in wavelengths over several hundred nanometers. To accomplish amplification of three orders of magnitude while maintaining the pulse length, a regenerative multipass amplifier system was built. The thesis describes theoretical design, realization and characterization of the system. Theoretical calculations and preliminary measurements were carried out and allow a critical evaluation of the final performance.

Schumacher, Andreas B.

1996-10-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Theoretical analyses predict A20 regulates period of NF-kB oscillation  

E-Print Network (OSTI)

The nuclear-cytoplasmic shuttling of NF-kB is characterized by damped oscillations of the nuclear concentration with a time period of around 1-2 hours. The NF-kB network contains several feedback loops modulating the overall response of NF-kB activity. While IkBa is known to drive and IkBe is known to dampen the oscillations, the precise role of A20 negative feedback remains to be elucidated. Here we propose a model of the NF-kB system focusing on three negative feedback loops (IkBa, IkBe and A20) which capture the experimentally observed responses in wild-type and knockout cells. We find that A20, like IkBe, efficiently dampens the oscillations albeit through a distinct mechanism. In addition, however, we have discovered a new functional role of A20 by which it controls the oscillation period of nuclear NF-kB. The design based on three nested feedback loops allows independent control of period and amplitude decay in the oscillatory response. Based on these results we predict that adjusting the expression lev...

Mengel, Benedicte; Jensen, Mogens H; Trusina, Ala

2009-01-01T23:59:59.000Z

122

Evolutionary Conserved Regulation of HIF-1b by NF-kB  

E-Print Network (OSTI)

Hypoxia Inducible Factor-1 (HIF-1) is essential for mammalian development and is the principal transcription factor activated by low oxygen tensions. HIF-a subunit quantities and their associated activity are regulated in a post-translational manner, through the concerted action of a class of enzymes called Prolyl Hydroxylases (PHDs) and Factor Inhibiting HIF (FIH) respectively. However, alternative modes of HIF-a regulation such as translation or transcription are under-investigated, and their importance has not been firmly established. Here, we demonstrate that NF-kB regulates the HIF pathway in a significant and evolutionary conserved manner. We demonstrate that NF-kB directly regulates HIF-1b mRNA and protein. In addition, we found that NF-kBmediated changes in HIF-1b result in modulation of HIF-2a protein. HIF-1b overexpression can rescue HIF-2a protein levels following NF-kB depletion. Significantly, NF-kB regulates HIF-1b (tango) and HIF-a (sima) levels and activity (Hph/fatiga, ImpL3/ldha) in Drosophila, both in normoxia and hypoxia, indicating an evolutionary conserved mode of regulation. These results reveal a novel mechanism of HIF regulation, with impact in the development of

Patrick Van Uden; Niall S. Kenneth; Ryan Webster; H. Arno Mller; Sharon Mudie; Sonia Rocha

2010-01-01T23:59:59.000Z

123

Endocytosis-Independent Function of Clathrin Heavy Chain in the Control of Basal NF-kB Activation  

E-Print Network (OSTI)

Background: Nuclear factor-kB (NF-kB) is a transcription factor that regulates the transcription of genes involved in a variety of biological processes, including innate and adaptive immunity, stress responses and cell proliferation. Constitutive or excessive NF-kB activity has been associated with inflammatory disorders and higher risk of cancer. In contrast to the mechanisms controlling inducible activation, the regulation of basal NF-kB activation is not well understood. Here we test whether clathrin heavy chain (CHC) contributes to the regulation of basal NF-kB activity in epithelial cells. Methodology: Using RNA interference to reduce endogenous CHC expression, we found that CHC is required to prevent constitutive activation of NF-kB and gene expression. Immunofluorescence staining showed constitutive nuclear localization of the NF-kB subunit p65 in absence of stimulation after CHC knockdown. Elevated basal p65 nuclear localization is caused by constitutive phosphorylation and degradation of inhibitor of NF-kB alpha (IkBa) through an IkB kinase a (IKKa)-dependent mechanism. The role of CHC in NF-kB signaling is functionally relevant as constitutive expression of the proinflammatory chemokine interleukin-8 (IL-8), whose expression is regulated by NF-kB, was found after CHC knockdown. Disruption of clathrin-mediated endocytosis by chemical inhibition or depletion of the m2-subunit of the endocytosis adaptor protein AP-2, and knockdown of clathrin light chain a (CHLa), failed to induce constitutive NF-kB activation and IL-8 expression, showing that CHC acts on NF-kB independently of endocytosis and CLCa.

Man Lyang Kim; Isabel Sorg; Ccile Arrieumerlou

2011-01-01T23:59:59.000Z

124

Investigating the role of intra- and extra-cellular modulators of the transcription factor NF-kappaB  

E-Print Network (OSTI)

The nuclear factor-kappa B (NF-kappaB) family of transcription factors play a pivotal role in the inflammatory and immune responses, as well as cell growth and survival. Since its discovery 25 years ago, NF-kappaB has ...

Nguyen, Hung Nhat

2011-01-01T23:59:59.000Z

125

Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells  

Science Conference Proceedings (OSTI)

A sampling of publications resulting from this grant is provided. One is on the subject of NF-κB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-κB-mediated adaptive resistance to ionizing radiation.

Jian Li

2012-11-07T23:59:59.000Z

126

FACILITY SAFETY (FS)  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

OBJECTIVE OBJECTIVE OP.1 - (Core Requirements 4 and 6) Sufficient numbers of qualified personnel are available to conduct and support operations. Adequate facilities and equipment are available to ensure operational support services are adequate for operations. The level of knowledge of managers, operations personnel, and support personnel is adequate based on reviews of examinations and examination results and selected interviews of personnel. (Old Core Requirements 3, 8, 13, and 19) Criteria 1. Minimum staffing requirements for safe operations have been established for operations personnel, supervisors, and managers. These staffing levels are met and are consistent with the safety basis requirements and assumptions. (DOE O 5480.19; WPF DSA) 2. All ES&H matrix support functions are identified for system operations. Adequate

127

FACILITY SAFETY (FS)  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

protection program has been established and implemented. (10 CFR 830.204(b)(5); 10 CFR 835; DOE O 5400.5; DOE N 441.3) 2. The radiological protection organization is...

128

FACILITY SAFETY (FS)  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

- (Core Requirement 1) Line management has established a QA program to ensure safe accomplishment of work. Personnel exhibit an awareness of public and worker safety, health, and...

129

NRP/Optineurin Cooperates with TAX1BP1 to Potentiate the Activation of NF-kB by Human T-Lymphotropic Virus  

E-Print Network (OSTI)

NRP/Optineurin Cooperates with TAX1BP1 to Potentiate the Activation of NF-kB by Human T Nuclear factor (NF)-kB is a major survival pathway engaged by the Human T-Lymphotropic Virus type 1 (HTLV-1) Tax protein. Tax1 activation of NF-kB occurs predominantly in the cytoplasm, where Tax1 binds NF-kB

Paris-Sud XI, Université de

130

Poxvirus Targeting of E3 Ligase b-TrCP by Molecular Mimicry: A Mechanism to Inhibit NF-kB Activation and  

E-Print Network (OSTI)

Poxvirus Targeting of E3 Ligase b-TrCP by Molecular Mimicry: A Mechanism to Inhibit NF-kB, Trinity College Dublin, Dublin, Ireland Abstract The transcription factor NF-kB is essential for immune degradation of IkBa. Here we describe an inhibitor of NF-kB from vaccinia virus that has a closely related

Utrecht, Universiteit

131

NF-kB activation by ultraviolet light not dependent on a nuclear signal  

Science Conference Proceedings (OSTI)

Exposure of mammalian cells to radiation triggers the ultraviolet (UV) response, which includes activation of activator protein-1 (AP-1) and nuclear factor kappa B (NF-kB). This was postulated to occur by induction of a nuclear signaling cascade by damaged DNA. Recently, induction of AP-1 by UV was shown to be mediated by a pathway involving Src tyrosine kinases and the Ha-Ras small guanosine triphosphate-binding protein, proteins located at the plasma membrane. It is demonstrated here that the same pathway mediates induction of NF-kB by UV. Because inactive NF-kB is stored in the cytosol, analysis of its activation directly tests the involvement of a nuclear-initiated signaling cascade. Enucleated cells are fully responsive to UV both in NF-kB induction and in activation of another key signaling event. Therefore, the UV response does not require a signal generated in the nucleus and is likely to be initiated at or near the plasma membrane.

Devary, Y.; Rosette, C.; DiDonato, J.A.; Karin, M. (Univ. of California, San Diego, CA (United States))

1993-09-10T23:59:59.000Z

132

Original article Induction of apoptosis and NF-B by quercetin  

E-Print Network (OSTI)

activity of NF-B, which may implicate an increasing resistance to their cytotoxicity. quercetin / TNF) Abstract -- Polyphenol quercetin induced apoptosis in proliferating murine L1210 lymphocytic cells. DNA promoting activity of quercetin was enhanced by physiological concentrations of TNF-. At the same time

Recanati, Catherine

133

IS NF-B A GOOD TARGET FOR CANCER THERAPY? HOPES AND PITFALLS  

E-Print Network (OSTI)

clear that aberrant regulation of NF-B and the signaling pathways that control its activity are involved and acquire drug resistance4, 5 . The current armamentarium of medical oncology includes many active, such as innate and adaptive immune responses, cell proliferation, cell death, and inflammation. It has become

Paris-Sud XI, Université de

134

Human papillomavirus type 16 E6 and E 7 proteins alter NF-kB in cultured cervical epithelial cells and inhibition of NF-kB promotes cell growth and immortalization  

Science Conference Proceedings (OSTI)

The NF-kB family of transcription factors regulates important biological functions including cell growth, survival and the immune response. We found that Human Papillomavirus type 16 (HPV-16) E7 and E6/E7 proteins inhibited basal and TNF-alpha-inducible NF-kB activity in human epithelial cells cultured from the cervical transformation zone, the anatomic region where most cervical cancers develop. In contrast, HPV-16 E6 regulated NF-kB in a cell type- and cell growth-dependent manner. NF-kB influenced immortalization of cervical cells by HPV16. Inhibition of NF-kB by an IkB alpha repressor mutant increased colony formation and immortalization by HPV-16. In contrast, activation of NF-kB by constitutive expression of p65 inhibited proliferation and immortalization. Our results suggest that inhibition of NF-kB by HPV-16 E6/E7 contributes to immortalization of cells from the cervical transformation zone.

Vandermark, Erik R.; Deluca, Krysta A.; Gardner, Courtney R.; Marker, Daniel F.; Schreiner, Cynthia N.; Strickland, David A.; Wilton, Katelynn M. [Department of Biology, Clarkson University, Potsdam, NY 13699-5805 (United States)] [Department of Biology, Clarkson University, Potsdam, NY 13699-5805 (United States); Mondal, Sumona [Department of Mathematics, Clarkson University, Potsdam, NY 13699-5805 (United States)] [Department of Mathematics, Clarkson University, Potsdam, NY 13699-5805 (United States); Woodworth, Craig D., E-mail: woodworth@clarkson.edu [Department of Biology, Clarkson University, Potsdam, NY 13699-5805 (United States)

2012-03-30T23:59:59.000Z

135

Purinergic Signaling is Required for Fluid Shear Stress-Induced NF-kB Translocation in Osteoblasts  

SciTech Connect

Fluid shear stress regulates gene expression in osteoblasts, in part by activation of the transcription factor NF-kB. We examined whether this process was under control of purinoceptor activation. MC3T3-E1 osteoblasts under static conditions expressed the NF-kB inhibitory protein IkB alpha and exhibited cytosolic localization of NF-kB. Under fluid shear stress, I?B? levels decreased, and concomitant nuclear localization of NF-kB was observed. Cells exposed to fluid shear stress in ATP-depleted medium exhibited no significant reduction in I?B?, and NF-kB remained within the cytosol. Similar results were found using oxidized ATP or Brilliant Blue G, P2X7 receptor antagonists, indicating that the P2X7 receptor is responsible for fluid shear-stress-induced I?B? degradation and nuclear accumulation of NF-kB. Pharmacologic blockage of the P2Y6 receptor also prevented shear-induced IkB alpha degradation. These phenomena involved neither ERK1/2 signaling nor autocrine activation by P2X7-generated lysophosphatidic acid. Our results suggest that fluid shear stress regulates NF-kB activity through the P2Y6 and P2X7 receptor.

Genetos, Damian C.; Karin, Norman J.; Geist, Derik J.; Donahue, Henry J.; Duncan, Randall L.

2011-04-01T23:59:59.000Z

136

Coal dust contiguity-induced changes in the concentration of TNF- and NF- B p65 on the ocular surface  

Science Conference Proceedings (OSTI)

To observe the influence of coal dust on ocular surface of coal miners and rabbits with coal dust contiguity on expression TNF- and NF- Bp65 and dry eye occurrence. Expression TNF- and NF- Bp65 in ocular surface were determined. Results showed tear production, BUT and lysozyme decreased for coal miners and rabbits with coal dust contiguity. Coal dust exposure was linked to development of xerophthalmia, and induced a higher expression of NF- B p65 and TNF- perhaps as a mechanism to resist coal dust ocular surface injury.

Sun, Z.Y.; Hong, J.; Liu, Z.Y.; Jin, X.D.; Gu, C.H. [China Medical University, Shenyang (China)

2009-07-01T23:59:59.000Z

137

Performance Audit of the Department of Energy's Improper Payment Reporting in the Fiscal Year 2011 Agency Financial Report, OAS-FS-12-07  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Performance Audit of the Performance Audit of the Department of Energy's Improper Payment Reporting in the Fiscal Year 2011 Agency Financial Report OAS-FS-12-07 March 2012 Department of Energy Washington, DC 20585 March 15, 2012 MEMORANDUM FOR THE SECRETARY for FROM: Gregory H. Friedman Inspector General SUBJECT: INFORMATION: Report on "Performance Audit of the Department of Energy's Improper Payment Reporting in the Fiscal Year 2011 Agency Financial Report" The attached report presents the results of an evaluation of the Department of Energy's Improper Payment Reporting in the Fiscal Year 2011 Agency Financial Report (AFR). To fulfill the Office of Inspector General's audit responsibilities, we contracted with the independent public

138

Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2009 Balance Sheet Audit, OAS-FS-12-08  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Department of Energy's Isotope Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2009 Balance Sheet OAS-FS-12-08 March 2012 ISOTOPE DEVELOPMENT AND PRODUCTION FOR RESEARCH AND APPLICATIONS PROGRAM Fiscal Year 2009 Annual Report and Balance Sheet September 30, 2009 i UNITED STATES DEPARTMENT OF ENERGY ISOTOPE DEVELOPMENT AND PRODUCTION FOR RESEARCH AND APPLICATIONS PROGRAM Fiscal Year 2009 Annual Report and Balance Sheet Table of Contents Page Management's Discussion and Analysis 1 Isotope Program Overview 2 Isotope Program Funding 4 Isotope Program Performance 5 Financial Performance 6 Management Challenges and Significant Issues 7 Balance Sheet Limitations 7

139

Audit Report - Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2010 Balance Sheet Audit, OAS-FS-13-09  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Audits and Inspections Audits and Inspections Audit Report Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2010 Balance Sheet Audit OAS-FS-13-09 January 2013 MEMORANDUM FOR THE DIRECTOR, OFFICE OF SCIENCE FROM: Daniel M. Weeber Assistant Inspector General for Office of Inspector General SUBJECT: INFORMATION Production for Research and Applications Program's Fiscal Year 2010 Balance Sheet Audit The attached report presents the results of the independent certified public accountants' audit of the Department of Energy's Isotope Development and Production for Research and Applications Program's (Isotope Program) and 2009. The Office of Inspector General (OIG) engaged the independent public accounting firm of

140

Agreement Execution Process Study: CRADAs and NF-WFO Agreements and the Speed of Business  

SciTech Connect

This report summarizes the findings of a study on the execution of Cooperative Research and Development Agreements (CRADAs) and Non-Federal Work for Others (NF-WFO) agreements across the U.S. Department of Energy (DOE) laboratory complex. The study provides quantitiative estimates of times required to negotiate and execute these agreements across the DOE complex. It identifies factors impacting on cycle times and describes best practicies used at various laboratories and site offices that reduce cycle times.

Harrer, Bruce J.; Cejka, Cheryl L.; Macklin, Richard; Miksovic, Ann

2011-02-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

NISTIR 7297-A FS-TST 2.0: Forensic Software Testing Support Tools Test Plan, Test Design Specifications, and Test Case Specification  

E-Print Network (OSTI)

imaging tools typically used in forensic investigations. The package includes programs that initialize disk drives, detect changes in disk content, and compare pairs of disks. This Internal Report consists of three parts. This is Part A, Test Plan, Test Design Specifications, and Test Case Specification. It covers the planning, design, and specification of testing of FS-TST 2.0. The setup of disk drives and the testing is to be performed in the Linux environment; however, some tests will require interaction with the MS-DOS operating system. Part B, Test Summary Report, is a companion document. It reports the result of testing the FS-TST 2.0 package according to Part A. Two programs might have had slightly more convenient behavior in erroneous cases, but no anomalies were found in testing. Part C, Code Review Report, is an additional companion document. It covers the planning and specification of reviewing all the source code in the package and reports the results of the code reviews. Nothing was found in the code reviews that should cause invalid results, that is, that should lead to an imaging tool with systematic errors being incorrectly passed as adhering to the assertions. The intended audience for this document should be familiar with the Linux operating system, computer operation, and computer hardware components such as hard drives.

Serban I. Gavrila

2005-01-01T23:59:59.000Z

142

TRIM30a negatively regulates TLR-mediated NF-jB activation by targeting TAB2 and TAB3 for degradation  

E-Print Network (OSTI)

of the transcription factor NF-kB and stress-activated protein kinases5 and then induces the expression of genes encoding immune and proinflammatory molecules6. Activation of NF-kB by a TLR signal depends on the activity of the inhibitor of NF-kB (IkB) kinase (IKK) complex. In turn, activation of both IKK and TAK1 (A002249

Tian, Weidong

143

IKKa and IKKb Each Function to Regulate NF-kB Activation in the TNF-Induced/Canonical Pathway  

E-Print Network (OSTI)

Background: Activation of the transcription factor NF-kB by cytokines is rapid, mediated through the activation of the IKK complex with subsequent phosphorylation and degradation of the inhibitory IkB proteins. The IKK complex is comprised of two catalytic subunits, IKKa and IKKb, and a regulatory protein known as NEMO. Using cells from mice that are genetically deficient in IKKb or IKKa, or using a kinase inactive mutant of IKKb, it has been proposed that IKKb is critical for TNF-induced IkB phosphorylation/degradation through the canonical pathway while IKKa has been shown to be involved in the noncanonical pathway for NF-kB activation. These conclusions have led to a focus on development of IKKb inhibitors for potential use in inflammatory disorders and cancer. Methodology: Analysis of NF-kB activation in response to TNF in MEFs reveals that IKKb is essential for efficient phosphorylation and subsequent degradation of IkBa, yet IKKa contributes to the NF-kB activation response in these cells as measured via DNA binding assays. In HeLa cells, both IKKa and IKKb contribute to IkBa phosphorylation and NF-kB activation. A kinase inactive mutant of IKKb, which has been used as evidence for the critical importance of IKKb in TNFinduced signaling, blocks activation of NF-kB induced by IKKa, even in cells that are deficient in IKKb. Conclusions: These results demonstrate the importance of IKKa in canonical NF-kB activation, downstream of cytokine

Mazhar Adli; Evan Merkhofer; Patricia Cogswell; Albert S. Baldwin

2009-01-01T23:59:59.000Z

144

Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2010 Balance Sheet Audit, OAS-FS-13-11  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2010 Balance Sheet Audit OAS-FS-13-11 February 2013 January 31, 2013 Mr. Gregory Friedman, Inspector General Dr. Jehanne Gillo, Director, Facilities and Project Management Division, Office of Nuclear Physics U.S. Department of Energy Washington, DC 20585 Dear Mr. Friedman and Dr. Gillo: We have audited the balance sheet of the United States Department of Energy's (Department or DOE) Isotope Development and Production for Research and Applications Program (the Program) (a component of the Department) as of September 30, 2010, and have issued our report thereon dated December 21, 2012. In planning and performing our audit of the balance sheet, in accordance with auditing standards

145

Management Letter on the Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2009 Balance Sheet Audit, OAS-FS-12-09  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

09 Balance 09 Balance Sheet Audit OAS-FS-12-09 June 2012 January 30, 2012 Mr. Gregory Friedman, Inspector General Dr. Jehanne Gillo, Director, Facilities and Project Management Division, Office of Nuclear Physics U.S. Department of Energy Washington, DC 20585 Dear Mr. Friedman and Dr. Gillo: We have audited the balance sheet of the United States Department of Energy's (Department or DOE) Isotope Development and Production for Research and Applications Program (the Program) (a component of the Department) as of September 30, 2009, and have issued our report thereon dated January 30, 2012. In planning and performing our audit of the balance sheet, in accordance with auditing standards generally accepted in the United States of America, we considered the Program's internal control over financial

146

Micro-joule sub-10-fs VUV pulse generation by MW pump pulse using highly efficient chirped-four-wave mixing in hollow-core photonic crystal fibers  

E-Print Network (OSTI)

We theoretically study chirped four-wave mixing for VUV pulse generation in hollow-core photonic crystal fibers. We predict the generation of sub-10-fs VUV pulses with energy of up to hundreds of microjoule by broad-band chirped idler pulses at 830 nm and MW pump pulses with narrow-band at 277 nm. MW pump could be desirable to reduce the complexity of the laser system or use a high repetition rate-laser system. The energy conversion efficiency from pump pulse to VUV pulse reaches to 30%. This generation can be realized in kagome-lattice hollow-core PCF filled with noble gas of high pressure with core-diameter less than 40 micrometers which would enable technically simple or highly efficient coupling to fundamental mode of the fiber.

Im, Song-Jin

2013-01-01T23:59:59.000Z

147

Audit Report - Management Letter on the Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 2012, OAS-FS-13-08  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Audit of Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 2012 OAS-FS-13-08 January 2013 i MANAGEMENT LETTER December 17, 2012 Mr. Gregory Friedman Inspector General U.S. Department of Energy 1000 Independence Avenue, S.W., Room 5D-039 Washington, DC 20585 Dear Mr. Friedman: We have audited the consolidated financial statements and special-purpose financial statements of the United States Department of Energy (Department or DOE) as of and for the year ended September 30, 2012, and have issued our reports thereon dated November 14, 2012. In planning and performing our audit of the consolidated financial statements and special-purpose financial statements, in accordance with auditing standards generally accepted in the United States of America; the standards applicable to

148

XIAP Induces NF-kB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization  

Science Conference Proceedings (OSTI)

In addition to caspase inhibition, X-linked inhibitor of apoptosis (XIAP) induces NF-{kappa}B and MAP kinase activation during TGF-b and BMP receptor signaling and upon overexpression. Here we show that the BIR1 domain of XIAP, which has no previously ascribed function, directly interacts with TAB1 to induce NF-{kappa}B activation. TAB1 is an upstream adaptor for the activation of the kinase TAK1, which in turn couples to the NF-{kappa}B pathway. We report the crystal structures of BIR1, TAB1, and the BIR1/TAB1 complex. The BIR1/TAB1 structure reveals a striking butterfly-shaped dimer and the detailed interaction between BIR1 and TAB1. Structure-based mutagenesis and knockdown of TAB1 show unambiguously that the BIR1/TAB1 interaction is crucial for XIAP-induced TAK1 and NF-{kappa}B activation. We show that although not interacting with BIR1, Smac, the antagonist for caspase inhibition by XIAP, also inhibits the XIAP/TAB1 interaction. Disruption of BIR1 dimerization abolishes XIAP-mediated NF-{kappa}B activation, implicating a proximity-induced mechanism for TAK1 activation.

Lu,M.; Lin, S.; Huang, Y.; Kang, Y.; Rich, R.; Lo, Y.; Myszka, D.; Han, J.; Wu, H.

2007-01-01T23:59:59.000Z

149

The Enteropathogenic E. coli (EPEC) Tir Effector Inhibits NF-kB Activity by Targeting TNFa Receptor-Associated Factors  

E-Print Network (OSTI)

Enteropathogenic Escherichia coli (EPEC) disease depends on the transfer of effector proteins into epithelia lining the human small intestine. EPEC E2348/69 has at least 20 effector genes of which six are located with the effector-delivery system genes on the Locus of Enterocyte Effacement (LEE) Pathogenicity Island. Our previous work implied that non-LEE-encoded (Nle) effectors possess functions that inhibit epithelial anti-microbial and inflammation-inducing responses by blocking NF-kB transcription factor activity. Indeed, screens by us and others have identified novel inhibitory mechanisms for NleC and NleH, with key co-operative functions for NleB1 and NleE1. Here, we demonstrate that the LEE-encoded Translocatedintimin receptor (Tir) effector has a potent and specific ability to inhibit NF-kB activation. Indeed, biochemical, imaging and immunoprecipitation studies reveal a novel inhibitory mechanism whereby Tir interaction with cytoplasm-located TNFa receptor-associated factor (TRAF) adaptor proteins induces their proteasomal-independent degradation. Infection studies support this Tir-TRAF relationship but reveal that Tir, like NleC and NleH, has a non-essential contribution in EPECs NF-kB inhibitory capacity linked to Tirs activity being suppressed by undefined EPEC factors. Infections in a disease-relevant intestinal model confirm key NF-kB inhibitory roles for the NleB1/NleE1 effectors, with other studies providing insights on host targets. The work not only reveals a second Intimin-independent property for Tir and a novel EPEC effector-mediated NF-kB inhibitory mechanism but also lends itself to speculations on the evolution of EPECs capacity to inhibit NF-kB

Marie-hlne Ruchaud-sparagano; Sabrina Mhlen; Paul Dean; Brendan Kenny

2011-01-01T23:59:59.000Z

150

The Surface Activation Layer of GaAs Negative Electron Affinity Photocathode Activated by Cs, Li and NF3  

Science Conference Proceedings (OSTI)

The lifetime of GaAs photocathodes can be greatly improved by introducing Li in the Cs+NF{sub 3} activation process. The surface activation layer of such photocathodes is studied by synchrotron radiation photoemission and is compared with GaAs photocathodes activated without Li. The charge distributions of N, F and Cs experience significant changes when Li is added in the activation. In addition, the presence of Li causes NF{sub x} molecules to take an orientation with F atoms on top. All these changes induced by Li hold the key for the lifetime improvement of GaAs photocathodes.

Sun, Yun; /SLAC, SSRL; Kirby, R.E.; /Saxet Surface Sci.; Maruyama, T.; /SLAC; Mulhollan, G.A.; Bierman, J.C.; /Saxet Surface Sci.; Pianetta, P.; /SLAC, SSRL

2009-12-11T23:59:59.000Z

151

Introducing Spatial Information into Predictive NF-kB Modelling An Agent-Based Approach  

E-Print Network (OSTI)

Nature is governed by local interactions among lower-level sub-units, whether at the cell, organ, organism, or colony level. Adaptive system behaviour emerges via these interactions, which integrate the activity of the sub-units. To understand the system level it is necessary to understand the underlying local interactions. Successful models of local interactions at different levels of biological organisation, including epithelial tissue and ant colonies, have demonstrated the benefits of such agent-based modelling [14]. Here we present an agent-based approach to modelling a crucial biological system the intracellular NF-kB signalling pathway. The pathway is vital to immune response regulation, and is fundamental to basic survival in a range of species [57]. Alterations in pathway regulation underlie a variety of diseases, including atherosclerosis and arthritis. Our modelling of individual molecules, receptors and genes provides a more comprehensive outline of regulatory network mechanisms than previously possible with equation-based approaches [8]. The method also permits consideration of structural parameters in pathway regulation; here we predict that inhibition of NF-kB is directly affected by actin filaments of the cytoskeleton sequestering excess inhibitors, therefore regulating steady-state and feedback

Mark Pogson; Mike Holcombe; Rod Smallwood; Eva Qwarnstrom

2008-01-01T23:59:59.000Z

152

The TCL1A Oncoprotein Interacts Directly with the NF-kB Inhibitor IkB  

E-Print Network (OSTI)

The T cell leukaemia/lymphoma 1A (TCL1A) oncoprotein plays key roles in several B and T cell malignancies. Lacking enzymatic activity, TCL1As transforming action was linked to its capacity to co-activate the protein kinase AKT via binding to its pleckstrin homology (PH) domain. However, perturbation of AKT signalling alone was recently shown insufficient to explain TCL1A oncogenesis, suggesting that TCL1A has additional cellular partners. Searching for such additional targets, we found that TCL1A binds specifically and directly to the ankyrin domain of IkB, the inhibitor of the NF-kB transcription factors. Through binding assays and a structural analysis by small angle X-ray scattering, we show that TCL1A and IkB interact in yeast-two-hybrid systems, when transiently overexpressed in 293 cells, and as recombinant proteins in vitro. We further establish that the association between TCL1A and IkB is compatible with AKT binding to TCL1A, but incompatible with IkB binding to NF-kB. By interfering with the inhibition of NF-kB byIkB, TCL1A may increase the concentration of free NF-kB molecules sufficiently to trigger expression of anti-apoptotic genes. Thus our data suggest an additional route by

Virginie Ropars; Gilles Despouy; Marc-henri Stern; Serge Benichou; Stefan T. Arold

2009-01-01T23:59:59.000Z

153

Nat Rev Drug Discov. Author manuscript Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls  

E-Print Network (OSTI)

and the signaling pathways that control its activity are involved in cancer development and progression, as well resistance , .4 5 The current armamentarium of medical oncology includes many active anticancer agents, cell proliferation, cell death, and inflammation. It has become clear that aberrant regulation of NF- B

Paris-Sud XI, Université de

154

Towards thermodynamics with $N_f=2+1+1$ twisted mass quarks  

E-Print Network (OSTI)

We present preliminary results achieved within a recently started project dealing with QCD thermodynamics in the presence of a fully dynamical second quark family. We are employing the Wilson twisted mass discretization. To reduce the amount of zero temperature simulations and the cost of analysis we have chosen the fixed-scale approach. We show a variety of basic thermodynamic observables for temperatures ranging from 158 to 633 MeV. Simulations were performed for three lattice spacings below 0.1 fm each and at a single value of the pion mass which allows a comparison with previously obtained $N_f=2$ results. We determine the chiral crossover temperature from the bare chiral susceptibility and show results for the gauge part of the trace anomaly.

Florian Burger; Grit Hotzel; Michael Mller-Preussker; Ernst-Michael Ilgenfritz; Maria Paola Lombardo

2013-11-07T23:59:59.000Z

155

B771 FS 2004.PDF  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

O O C K Y F L A T S C L O S U R E P R O J E C T "THE MOST DANGEROUS BUILDING IN AMERICA" READY FOR DEMOLITION K e y M i l e s t o n e s * 1953: Operations began in May * 1957: Large fire spread plutoni- um contamination throughout much of the building * 1993: Started stabilizing bottled plutonium solutions * 1994: Began draining plutonium solutions from tanks * 1997: High-priority plutonium solutions drained from all tanks * 1997: All weapons-usable special nuclear materials removed * 1998: Began draining and removing plutonium process pip- ing * 1999: High security area eliminated following removal of all attractive quantities of SNM "holdup" * 2001: Last plutonium liquids removed and treated * 2002: Last glovebox removed * 2003: Facility no longer contains quantities of fissile material that

156

Bachelor Thesis/ Semester Project -FS  

E-Print Network (OSTI)

information on the heat load acting on the endwalls of gas turbine blade and vane rows. An Infrared camera software, starting from the already available tools developed at LEC. Specifically, the program will have; - perform uncertainty analysis. The possibility of introducing different image registration

Daraio, Chiara

157

Determining the conformal window: SU(2) gauge theory with N_f = 4, 6 and 10 fermion flavours  

E-Print Network (OSTI)

We study the evolution of the coupling in SU(2) gauge field theory with $N_f=4$, 6 and 10 fundamental fermion flavours on the lattice. These values are chosen close to the expected edges of the conformal window, where the theory possesses an infrared fixed point. We use improved Wilson-clover action, and measure the coupling in the Schr\\"odinger functional scheme. At four flavours we observe that the couping grows towards the infrared, implying QCD-like behaviour, whereas at ten flavours the results are compatible with a Banks-Zaks type infrared fixed point. The six flavour case remains inconclusive: the evolution of the coupling is seen to become slower at the infrared, but the accuracy of the results falls short from fully resolving the fate of the coupling. We also measure the mass anomalous dimension for the $N_f=6$ case.

Tuomas Karavirta; Jarno Rantaharju; Kari Rummukainen; Kimmo Tuominen

2011-11-17T23:59:59.000Z

158

KT McDonald IDS-NF Plenary Meeting (RAL) Apr 6, 20132 1 Engineering Issues for the  

E-Print Network (OSTI)

Diagnostics Controls and Interlocks Health and Safety Mechanical Decommissioning Remote Handling and Hot Cells 10,730,099 1.06.07 - Remote Handling Systems 14,348,362 1.06.08 - Controls 3,076,899 1.06.09 - Beam. #12;KT McDonald IDS-NF Plenary Meeting (RAL) Apr 6, 20132 19 We must have an activated-air handling

McDonald, Kirk

159

GEF-H1 Mediated Control of NOD1 Dependent NF-kB Activation by Shigella Effectors  

E-Print Network (OSTI)

Shigella flexneri has evolved the ability to modify host cell function with intracellular active effectors to overcome the intestinal barrier. The detection of these microbial effectors and the initiation of innate immune responses are critical for rapid mucosal defense activation. The guanine nucleotide exchange factor H1 (GEF-H1) mediates RhoA activation required for cell invasion by the enteroinvasive pathogen Shigella flexneri. Surprisingly, GEF-H1 is requisite for NF-kB activation in response to Shigella infection. GEF-H1 interacts with NOD1 and is required for RIP2 dependent NF-kB activation by H-Ala-DcGlu-DAP (cTriDAP). GEF-H1 is essential for NF-kB activation by the Shigella effectors IpgB2 and OspB, which were found to signal in a NOD1 and RhoA Kinase (ROCK) dependent manner. Our results demonstrate that GEF-H1 is a critical component of cellular defenses forming an intracellular sensing system with NOD1 for the detection of microbial effectors during cell

Atsuko Fukazawa; Carmen Alonso; Kiyotaka Kurachi; Sonal Gupta; Cammie F. Lesser; Beth Ann; Hans-christian Reinecker

2008-01-01T23:59:59.000Z

160

Dual Delayed Feedback Provides Sensitivity and Robustness to the NF-kB Signaling Module  

E-Print Network (OSTI)

Many cellular stress-responsive signaling systems exhibit highly dynamic behavior with oscillatory features mediated by delayed negative feedback loops. What remains unclear is whether oscillatory behavior is the basis for a signaling code based on frequency modulation (FM) or whether the negative feedback control modules have evolved to fulfill other functional requirements. Here, we use experimentally calibrated computational models to interrogate the negative feedback loops that regulate the dynamic activity of the transcription factor NF-kB. Linear stability analysis of the model shows that oscillatory frequency is a hard-wired feature of the primary negative feedback loop and not a function of the stimulus, thus arguing against an FM signaling code. Instead, our modeling studies suggest that the two feedback loops may be tuned to provide for rapid activation and inactivation capabilities for transient input signals of a wide range of durations; by minimizing late phase oscillations response durations may be fine-tuned in a graded rather than quantized manner. Further, in the presence of molecular noise the dual delayed negative feedback system minimizes stochastic

Diane M. Longo; Jangir Selimkhanov; Jeffrey D. Kearns; Jeff Hasty; Er Hoffmann; Lev S. Tsimring

2013-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

NF-kB Hyper-Activation by HTLV-1 Tax Induces Cellular Senescence, but Can Be Alleviated by the Viral Anti- Sense Protein HBZ  

E-Print Network (OSTI)

Activation of I-kB kinases (IKKs) and NF-kB by the human T lymphotropic virus type 1 (HTLV-1) trans-activator/oncoprotein, Tax, is thought to promote cell proliferation and transformation. Paradoxically, expression of Tax in most cells leads to drastic up-regulation of cyclin-dependent kinase inhibitors, p21 CIP1/WAF1 and p27 KIP1, which cause p53-/pRb-independent cellular senescence. Here we demonstrate that p21 CIP1/WAF1-/p27 KIP1-mediated senescence constitutes a checkpoint against IKK/NF-kB hyper-activation. Senescence induced by Tax in HeLa cells is attenuated by mutations in Tax that reduce IKK/NFkB activation and prevented by blocking NF-kB using a degradation-resistant mutant of I-kBa despite constitutive IKK activation. Small hairpin RNA-mediated knockdown indicates that RelA induces this senescence program by acting upstream of the anaphase promoting complex and RelB to stabilize p27 KIP1 protein and p21 CIP1/WAF1 mRNA respectively. Finally, we show that down-regulation of NF-kB by the HTLV-1 anti-sense protein, HBZ, delay or prevent the onset of Taxinduced senescence. We propose that the balance between Tax and HBZ expression determines the outcome of HTLV-1 infection. Robust HTLV-1 replication and elevated Tax expression drive IKK/NF-kB hyper-activation and trigger senescence. HBZ, however, modulates Tax-mediated viral replication and NF-kB activation, thus allowing HTLV-1-infected cells to proliferate, persist, and evolve. Finally, inactivation of the senescence checkpoint can facilitate persistent NF-kB activation

Huijun Zhi; Liangpeng Yang; Yu-liang Kuo; Yik-khuan Ho; Hsiu-ming Shih; Chou-zen Giam

2011-01-01T23:59:59.000Z

162

Non-Canonical NF-kB Activation and Abnormal B Cell Accumulation in Mice Expressing Ubiquitin Protein Ligase-Inactive c-IAP2  

E-Print Network (OSTI)

Chromosomal translocations between loci encoding MALT1 and c-IAP2 are common in MALT lymphomas. The resulting fusion proteins lack the c-IAP2 RING domain, the region responsible for its ubiquitin protein ligase (E3) activity. Ectopic expression of the fusion protein activates the canonical NF-kB signaling cascade, but how it does so is controversial and how it promotes MALT lymphoma is unknown. Considering recent reports implicating c-IAP1 and c-IAP2 E3 activity in repression of non-canonical NF-kB signaling, we asked if the c-IAP2/MALT fusion protein can initiate non-canonical NF-kB activation. Here we show that in addition to canonical activation, the fusion protein stabilizes NIK and activates noncanonical NF-kB. Canonical but not non-canonical activation depended on MALT1 paracaspase activity, and expression of E3-inactive c-IAP2 activated non-canonical NF-kB. Mice in which endogenous c-IAP2 was replaced with an E3-inactive mutant accumulated abnormal B cells with elevated non-canonical NF-kB and had increased numbers of B cells with a marginal zone phenotype, gut-associated lymphoid hyperplasia, and other features of MALT lymphoma. Thus, the c-IAP2/ MALT1 fusion protein activates NF-kB by two distinct mechanisms, and loss of c-IAP2 E3 activity in vivo is sufficient to induce abnormalities common to MALT lymphoma.

Dietrich B. Conze; Yongge Zhao; Jonathan D. Ashwell

2010-01-01T23:59:59.000Z

163

Dual mechanisms of NF-kappaB inhibition in carnosol-treated endothelial cells  

Science Conference Proceedings (OSTI)

The increased adhesion of monocytes to injured endothelial layers is a critical early event in atherogenesis. Under inflammatory conditions, there is increased expression of specific cell adhesion molecules on activated vascular endothelial cells, which increases monocyte adhesion. In our current study, we demonstrate a putative mechanism for the anti-inflammatory effects of carnosol, a diterpene derived from the herb rosemary. Our results show that both carnosol and rosemary essential oils inhibit the adhesion of TNFalpha-induced monocytes to endothelial cells and suppress the expression of ICAM-1 at the transcriptional level. Moreover, carnosol was found to exert its inhibitory effects by blocking the degradation of the inhibitory protein IkappaBalpha in short term pretreatments but not in 12 h pretreatments. Our data show that carnosol reduces IKK-beta phosphorylation in pretreatments of less than 3 h. In TNFalpha-treated ECs, NF-kappaB nuclear translocation and transcriptional activity was abolished by up to 12 h of carnosol pretreatment and this was blocked by Nrf-2 siRNA. The long-term inhibitory effects of carnosol thus appear to be mediated through its induction of Nrf-2-related genes. The inhibition of ICAM-1 expression and p65 translocation is reversed by HO-1 siRNA. Carnosol also upregulates the Nrf-2-related glutathione synthase gene and thereby increases the GSH levels after 9 h of exposure. Treating ECs with a GSH synthesis inhibitor, BSO, blocks the inhibitory effects of carnosol. In addition, carnosol increases p65 glutathionylation. Hence, our present findings indicate that carnosol suppresses TNFalpha-induced singling pathways through the inhibition of IKK-beta activity or the upregulation of HO-1 expression. The resulting GSH levels are dependent, however, on the length of the carnosol pretreatment period.

Lian, K.-C.; Chuang, J.-J.; Hsieh, C.-W. [Department of Microbiology and Immunology, National Chiayi University, Chiayi, Taiwan (China); Wung, B.-S., E-mail: bswung@mail.ncyu.edu.t [Department of Microbiology and Immunology, National Chiayi University, Chiayi, Taiwan (China); Huang, G.-D.; Jian, T.-Y. [Department of Microbiology and Immunology, National Chiayi University, Chiayi, Taiwan (China); Sun, Y.-W. [Department of Biotechnology, Seed Improvement and Propagation Station, Taichung, Taiwan (China)

2010-05-15T23:59:59.000Z

164

Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling  

SciTech Connect

SET domain containing 6 (SETD6) monomethylates the RelA subunit of nuclear factor kappa B (NF-{kappa}B). The ankyrin repeats of G9a-like protein (GLP) recognizes RelA monomethylated at Lys310. Adjacent to Lys310 is Ser311, a known phosphorylation site of RelA. Ser311 phosphorylation inhibits Lys310 methylation by SETD6 as well as binding of Lys310me1 by GLP. The structure of SETD6 in complex with RelA peptide containing the methylation site, in the presence of S-adenosyl-l-methionine, reveals a V-like protein structure and suggests a model for NF-{kappa}B binding to SETD6. In addition, structural modeling of the GLP ankyrin repeats bound to Lys310me1 peptide provides insight into the molecular basis for inhibition of Lys310me1 binding by Ser311 phosphorylation. Together, these findings provide a structural explanation for a key cellular signaling pathway centered on RelA Lys310 methylation, which is generated by SETD6 and recognized by GLP, and incorporate a methylation-phosphorylation switch of adjacent lysine and serine residues. Finally, SETD6 is structurally similar to the Rubisco large subunit methyltransferase. Given the restriction of Rubisco to plant species, this particular appearance of the protein lysine methyltransferase has been evolutionarily well conserved.

Chang, Yanqi; Levy, Dan; Horton, John R.; Peng, Junmin; Zhang, Xing; Gozani, Or; Cheng, Xiaodong (Emory-MED); (Stanford)

2011-10-10T23:59:59.000Z

165

Regulation of cytochrome P450 3A4 gene expression through modulating pregnane X receptor transcriptional activity by NF-? aryl hydrocarbon receptor and xenobiotics  

E-Print Network (OSTI)

Cytochrome P450 3A4 (CYP3A4) is a key enzyme responsible for the metabolism of drugs and endogenous compounds in human liver and intestine. CYP3A4 gene expression is mainly regulated by Pregnane X receptor (PXR) which is a ligand-dependent nuclear receptor. It is a long-standing observation that inflammatory responses and infections decrease drug metabolism capacity in human and experimental animals. In this study, I reported that NF-?B activation by LPS and TNF-? plays a pivotal role in the suppression of CYP3A4 through interactions of NF-?B with PXR/RXR complex. Inhibition of NF-?B by NF-?B specific suppressor SRI?B? reversed the suppressive effects of LPS and TNF-?. Furthermore, I showed that NF-?B p65 disrupted the association of PXR/RXR? complex with DNA sequences as determined by EMSA and chromatin immunoprecipitation assays. NF-?B p65 directly interacted with DNA binding domain of RXR? and DNA binding domain, hinge domain and ligand-binding domain of PXR and may prevent its binding to the consensus DNA sequences, thus inhibiting the transactivation by PXR/RXR? complex. This mechanism of suppression by NF-?B activation may be extended to other nuclear receptor-regulated systems where RXR? is a dimerization partner. Many genes regulated by PXR and AhR are important for phase I, II and III drug metabolism. In this study I reported a crosstalk between PXR and AhR pathways. AhR physically and functionally interacted with PXR and enhanced the PXR transcriptional activity, and the interaction repressed the AhR transcriptional activity. AhR also physically interacted with RXR?. The synergistic induction of Gsta1 in the liver of mice by PCN and TCDD might assume a different mechanism. The results suggested the metabolism kinetics of mixture drugs was different from and more complicated than that of single compound. Using a HepG2 cell-based PXR-driven CYP3A4-Luciferase assay, I reported that E/F domain of PXR was responsible for ligand-dependant activation. A/B domain was necessary for co-activating the ligand-dependent activation and D domain was suppressive. High doses of Valerian Root extraction were PXR-dependent CYP3A4 inducers. Green tea polyphenols, aflatoxin B1, CuSO4 and MnCl2 enhanced the PXR transcription activity activated by rifampicin. The results suggested PXR-mediated drug metabolism kinetics altered on xenobiotic exposure.

Gu, Xinsheng

2007-08-01T23:59:59.000Z

166

Effect of phenobarbital on hepatic cell proliferation and apoptosis in mice deficient in the p50 subunit of NF-{kappa}B  

Science Conference Proceedings (OSTI)

Phenobarbital (PB) is a nongenotoxic tumor promoter in the liver. One mechanism by which PB may exert its tumor promoting activity is by inducing oxidative stress. We previously found that PB administration increased hepatic NF-{kappa}B DNA binding activity. In this study we examined the hypothesis that the effects of PB on cell proliferation and apoptosis are dependent on NF-{kappa}B. We used a mouse model that is deficient in the p50 subunit of NF-{kappa}B; previous studies had found that p50-/- mice were less sensitive to the induction of hepatic cell proliferation by PCBs or peroxisome proliferators. Mice (p50-/- and wild-type B6129) were fed a control diet or one containing 0.05% PB for 3, 10 or 34 days. At the end of the experiment, the mice were euthanized and livers removed and processed. PB increased cell proliferation at 3 and 10 days (but not at 34 days), but the deletion of the NF-{kappa}B p50 subunit did not inhibit these increases. p50-/- Mice had higher cell proliferation at the 3 day (only in mice fed PB) and 34-day timepoints. PB decreased hepatocyte apoptosis after 3 days, slightly decreased it after 10 days, and did not affect it after 34 days. The deletion of the NF-{kappa}B p50 subunit did not influence PB's effect on apoptosis. In p50-/- mice, apoptosis was increased after 3 or 10 days compared to wild-type mice, but no effect was seen after 34 days. The hepatic expression of the NF-{kappa}B-regulated gene TNF-{alpha} correlated more with the hepatic cell proliferation data than with hepatic apoptosis, and was not decreased by the deletion of the p50 subunit. These findings show that the p50 subunit of NF-{kappa}B is not required for the alteration of hepatocyte proliferation or apoptosis by PB up to 34 days after its administration.

Tharappel, Job C. [Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky (United States); Spear, Brett T. [Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky (United States); Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky (United States); Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (United States); Glauert, Howard P. [Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky (United States); Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky (United States)], E-mail: hglauert@uky.edu

2008-02-01T23:59:59.000Z

167

Artemisolide is a typical inhibitor of I{kappa}B kinase {beta} targeting cysteine-179 residue and down-regulates NF-{kappa}B-dependent TNF-{alpha} expression in LPS-activated macrophages  

SciTech Connect

Nuclear factor (NF)-{kappa}B regulates a central common signaling for immunity and cell survival. Artemisolide (ATM) was previously isolated as a NF-{kappa}B inhibitor from a plant of Artemisia asiatica. However, molecular basis of ATM on NF-{kappa}B activation remains to be defined. Here, we demonstrate that ATM is a typical inhibitor of I{kappa}B kinase {beta} (IKK{beta}), resulting in inhibition of lipopolysaccharide (LPS)-induced NF-{kappa}B activation in RAW 264.7 macrophages. ATM inhibited the kinase activity of highly purified IKK{beta} and also LPS-induced IKK activity in the cells. Moreover, the effect of ATM on IKK{beta} activity was completely abolished by substitution of Cys-179 residue of IKK{beta} to Ala residue, indicating direct targeting site of ATM. ATM could inhibit I{kappa}B{alpha} phosphorylation in LPS-activated RAW 264.7 cells and subsequently prevent NF-{kappa}B activation. Further, we demonstrate that ATM down-regulates NF-{kappa}B-dependent TNF-{alpha} expression. Taken together, this study provides a pharmacological potential of ATM in NF-{kappa}B-dependent inflammatory disorders.

Kim, Byung Hak; Lee, Jun-Young; Seo, Jee Hee; Lee, Hwa Young [College of Pharmacy, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Ryu, Shi Yong [Korea Research Institute of Chemical Technology, Taejon 305-600 (Korea, Republic of); Ahn, Byung Woo [College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Lee, Chong-Kil; Hwang, Bang Yeon; Han, Sang-Bae [College of Pharmacy, Chungbuk National University, Cheongju 361-763 (Korea, Republic of); Kim, Youngsoo [College of Pharmacy, Chungbuk National University, Cheongju 361-763 (Korea, Republic of)], E-mail: youngsoo@chungbuk.ac.kr

2007-09-28T23:59:59.000Z

168

$K$ and $D$ oscillations in the Standard Model and its extensions from $N_f=2+1+1$ Twisted Mass LQCD  

E-Print Network (OSTI)

We present the first $N_f=2+1+1$ results for the matrix elements of the operators describing neutral $K$ and $D$ mixing in the Standard Model and its extensions. The combination of maximally twisted sea quarks and Osterwalder-Seiler valence quarks ensures $\\mathcal{O}(a)$-improvement and continuum like renormalization pattern. We have used the $N_f=2+1+1$ dynamical quark gauge configurations generated by ETMC. Simulations include three lattice spacings in the interval $[0.06:0.09]$ fm and pseudoscalar meson masses in the range $[230:500]$ MeV. Our results are extrapolated to the continuum limit and to the physical quark masses. The calculation of the renormalization constants has been performed non-perturbatively in the RI-MOM scheme.

Carrasco, Nuria; Frezzotti, Roberto; Gimnez, Vicent; Lubicz, Vittorio; Rossi, Giancarlo; Sanfilippo, Francesco; Tarantino, Cecilia

2013-01-01T23:59:59.000Z

169

The human NFKB3 gene encoding the p65 subunit of transcription factor NF-[sub K]B is located on chromosome 11q12  

SciTech Connect

A YAC clone that contains the human gene NFKB3, encoding the p65 subunit of transcription factor nuclear factor [sub K]B (NF-[sub K]B), was isolated. The YAC contains the entire NFKB3 gene, which is smaller than 15 kb and present in a single copy in the genome. Fluorescence in situ hybridization with metaphase chromosomes showed two different chromosomal locations (11q12 and Xp11.4) for sequences present in the YAC. The NFKB3 gene was assigned to chromosome 11q12 by PCR analysis of a panel of relevant hybrid cell lines. Thus, no linkage exists between NFKB3 and genes encoding other known members of the NF-[sub K]B family. 20 refs., 2 figs.

Deloukas, P.; Loon, A.P.G.M. van (F. Hoffmann-La Roche Ltd., Basel (Switzerland)); Dauwerse, J.G.; Ommen, G.J.B. van (Univ. of Leiden (Netherlands))

1994-02-01T23:59:59.000Z

170

Fucoidan prevents C{epsilon} germline transcription and NF{kappa}B p52 translocation for IgE production in B cells  

SciTech Connect

Fucoidan, a dietary fiber contained in seaweed, reduces the increase of antigen-specific IgE in mice exposed to ovalbumin. In this study, we investigated the effect of fucoidan on IgE production and intracellular events in B cells in vitro. Fucoidan inhibited the production of IgE and C{epsilon} germline transcription in murine B cells induced by IL-4 (100 ng/ml) and anti-CD40 antibodies (10 {mu}g/ml), whereas it stimulated cell proliferation. A significant effect of fucoidan on IgE production was observed when B cells were stimulated with a higher dose (5 {mu}g/ml) of anti-CD40 antibodies, but not when stimulated with lower doses (1.25, 2.5 {mu}g/ml), regardless of the IL-4 concentrations. Moreover, nuclear translocation of NF{kappa}B p52, but neither that of NF{kappa}B p65, nor the phosphorylation of JAK1 and STAT6 was reduced by fucoidan. These results suggest that fucoidan inhibited IgE production by preventing the NF{kappa}B p52-mediated pathways activated by CD40.

Oomizu, Souichi [Hiroshima Prefectural Institute of Industrial Science and Technology, Higashi-Hiroshima (Japan); Yanase, Yuhki [Hiroshima Prefectural Institute of Industrial Science and Technology, Higashi-Hiroshima (Japan); Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan); Suzuki, Hidenori [Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan); Kameyoshi, Yoshikazu [Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan); Hide, Michihiro [Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan)]. E-mail: mhide@hiroshima-u.ac.jp

2006-11-24T23:59:59.000Z

171

Research Article Curcumin Decreased Oxidative Stress, Inhibited NF-?B Activation, and Improved Liver Pathology in Ethanol-Induced Liver Injury in Rats  

E-Print Network (OSTI)

To study the mechanism of curcumin-attenuated inflammation and liver pathology in early stage of alcoholic liver disease, female Sprague-Dawley rats were divided into four groups and treated with ethanol or curcumin via an intragastric tube for 4 weeks. A control group treated with distilled water, and an ethanol group was treated with ethanol (7.5 g/kg bw). Treatment groups were fed with ethanol supplemented with curcumin (400 or 1 200 mg/kg bw). The liver histopathology in ethanol group revealed mild-tomoderate steatosis and mild necroinflammation. Hepatic MDA, hepatocyte apoptosis, and NF-?B activation increased significantly in ethanol-treated group when compared with control. Curcumin treatments resulted in improving of liver pathology, decreasing the elevation of hepatic MDA, and inhibition of NF-?B activation. The 400 mg/kg bw of curcumin treatment revealed only a trend of decreased hepatocyte apoptosis. However, the results of SOD activity, PPAR? protein expression showed no difference among the groups. In conclusion, curcumin improved liver histopathology in early stage of ethanol-induced liver injury by reduction of oxidative stress and inhibition of NF-?B activation. Copyright 2009 Suchittra Samuhasaneeto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1.

Suchittra Samuhasaneeto; Duangporn Thong-ngam; Onanong Kulaputana; Doungsamon Suyasunanont; Naruemon Klaikeaw

2009-01-01T23:59:59.000Z

172

oetd_fs_trp1.indd  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Areas Areas Transmission Reliability Program Mission To develop technologies and policy options that will contribute to maintaining and enhancing the reliability of the nation's electric power delivery system during the transition to competitive electricity markets. Program Areas Activities within the Transmission Reliability Program are organized into four categories. See the box to

173

LDRD Final Report - 01-FS-004  

SciTech Connect

This report describes the results from an experimental program to investigate the feasibility of laser produced MeV protons as a diagnostic of electric fields or shock compressed materials. The experimental campaign was very successful, and has led to substantial advances in the characterization and optimization of proton sources from ultra-intense laser-solid interaction. This is a subject of the highest scientific interest [1] and is highly relevant to developing its use as a possible NIF implosion diagnostic and other applications relevant to stockpile stewardship.

Mackinnon, A J

2002-01-23T23:59:59.000Z

174

oetd_fs_edtp1.indd  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Offi ce of Electricity Delivery & Energy Reliability Offi ce of Electricity Delivery & Energy Reliability US Department of Energy - 1000 Independence Avenue, SW - Washington, DC 20585 Overview Overview U.S. Department of Energy Offi ce of Electricity Delivery & Energy Reliability Program Areas Electric Distribution Transformation Program Mission Transforming today's electric distribution infrastructure for increased affordability, security,

175

FEMP-FS--Solar Ventilation Preheating  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Installing a "solar wall" to heat air before it enters a Installing a "solar wall" to heat air before it enters a building, called solar ventilation preheating, is one of the most efficient ways of reducing energy costs using clean and renewable energy. The system works by heating outside air with a south-facing solar collector-a dark-colored wall made of sheet metal and perforated with tiny holes. Outdoor air is drawn through the holes and heated as it absorbs the wall's warmth. The warm air rises in the space between the solar wall and the building wall and is moved into the air-duct system, usually by means of a fan, to heat the building. Any additional heating needed at night or on cloudy days is supplied by the build- ing's conventional heating system. During summer months, intake air bypasses the solar collector,

176

oetd_fs_emtap1.indd  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

other organizations to implement policy and market solutions that bring about improved demand response, energy effi ciency, renewable energy, and transmission utilization....

177

Laser Lithography: Heidelberg DWL-66FS  

Science Conference Proceedings (OSTI)

... High resolution pattern generator for low volume mask ... photomask blanks as well as direct patterning of ... gov Address: 100 Bureau Drive, Stop 6201 ...

2013-04-20T23:59:59.000Z

178

DETEW!INATION OF THE NEUTRON MAGNETIC FlONENT G.L. Greene and N.F. Ramsey  

NLE Websites -- All DOE Office Websites (Extended Search)

DETEW!INATION OF THE NEUTRON MAGNETIC FlONENT DETEW!INATION OF THE NEUTRON MAGNETIC FlONENT * G.L. Greene and N.F. Ramsey Harvard U n i v e r s i t y , Cambridge, N a s s a c h u s e t t s 02138 h W. Plampe i - I n s t i t u t Laue-Langevin, 38042 Grenoble, France' 9/ \ P J . M . P e n d l e b u r y and K. Smith " ' , \30ddb * A , 4 U n i v e r s i t y o f S u s s e x , Falmer, B r i g h t o n , B N I 9 Q H , U n i t e d Kingdom W . B . Dress and P.D. Miller -3 Oak Ridge N a t i o n a l L a b o r a t o r y , Oak Ridge, Tennessee 37838 P a u l P e r r i n C e n t r e d ' E t u d e s N u c l e a i r e s , 38042 C r e n o b l e , F r a n c e The n e u t r o n m a g n e t i c moment h a s been measured w i t h an improvement of a f a c t o r of 100 o v e r t h e p r e v i o u s b e s t measurement. s p e c t r o m e t e r o f t h e s e p a r a t e d o s c i l l a t o r y f i e l d t y p e c a p a b l e o f d e t e r m i n i n g a r e s o n a n c e s i g n a l f o r b o t h n e u t r o n s and p r o t o n s ( i n f l o w i n g H20), we f i n d u n / p p = 0.68497935(17)

179

Astroglial Inhibition of NF-kB Does Not Ameliorate Disease Onset and Progression in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)  

E-Print Network (OSTI)

Motor neuron death in amyotrophic lateral sclerosis (ALS) is considered a non-cell autonomous process, with astrocytes playing a critical role in disease progression. Glial cells are activated early in transgenic mice expressing mutant SOD1, suggesting that neuroinflammation has a relevant role in the cascade of events that trigger the death of motor neurons. An inflammatory cascade including COX2 expression, secretion of cytokines and release of NO from astrocytes may descend from activation of a NF-kB-mediated pathway observed in astrocytes from ALS patients and in experimental models. We have attempted rescue of transgenic mutant SOD1 mice through the inhibition of the NF-kB pathway selectively in astrocytes. Here we show that despite efficient inhibition of this major pathway, double transgenic mice expressing the mutant SOD1 G93A ubiquitously and the dominant negative form of IkBa (IkBaAA) in astrocytes under control of the GFAP promoter show no benefit in terms of onset and progression of disease. Our data indicate that motor neuron death in ALS cannot be prevented by inhibition of a single inflammatory pathway because alternative pathways are activated in the

Claudia Crosio; Cristiana Valle; Arianna Casciati; Ciro Iaccarino; Maria Teresa Carr

2011-01-01T23:59:59.000Z

180

nf]r Z  

E-Print Network (OSTI)

Dear Dr. Eggenberger: This letter provides a status ofthe Office of Environmental Management (EM) actions to complete Commitment 4.4 ofthe Department ofEnergy's (DOE) Implementation Plan for Recommendation 2002-3, Requirements for the Design, Implementation, and Maintenance ofAdministrative Controls. The commitment calls for the submission ofa report on training completed and copies ofchanges to relevant training plans regarding DOE-STD-II86-2004, Specific Administrative Controls. On November 4, 2004, the Secretary revised the due date to May 31, 2005, to allow additional time after the issuance ofthe standard in August 2004. We expect all EM actions under this commitment to be met within 90 days. EM sites and activities have completed the required initial training, except for one site. The contractor at the Richland Operations Office has initiated training and will complete the training in early June 2005. A summary ofthe training conducted at EM sites is enclosed. In addition, a compact disc containing the detailed training modules has been provided to your staff. EM sites are using a variety ofmeans to institutionalize DOE STD-1186-2004 into the various training programs as shown in the enclosure. These activities are in progress and are to be completed within 90 days. Ifyou have any further questions, please call me at (202) 586-7709 or

Jij-j L. L' i U H; I L. -' " ' i; The Honorable; A. J. Eggenberger

2005-01-01T23:59:59.000Z

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181

Eu{sub 3}F{sub 4}S{sub 2}: Synthesis, crystal structure, and magnetic properties of the mixed-valent europium(II,III) fluoride sulfide EuF{sub 2}.(EuFS){sub 2}  

Science Conference Proceedings (OSTI)

Using the method to synthesize rare-earth metal(III) fluoride sulfides MFS (M=Y, La, Ce-Lu), in some cases we were able to obtain mixed-valent compounds such as Yb{sub 3}F{sub 4}S{sub 2} instead. With Eu{sub 3}F{sub 4}S{sub 2} another isotypic representative has now been synthesized. Eu{sub 3}F{sub 4}S{sub 2} (tetragonal, I4/mmm, a=400.34(2), c=1928.17(9) pm, Z=2) is obtained from the reaction of metallic europium, elemental sulfur, and europium trifluoride in a molar ratio of 5:6:4 within seven days at 850 deg. C in silica-jacketed gas-tightly sealed platinum ampoules. The single-phase product consists of black plate-shaped single crystals with a square cross section, which can be obtained from a flux using equimolar amounts of NaCl as fluxing agent. The crystal structure is best described as an intergrowth structure, in which one layer of CaF{sub 2}-type EuF{sub 2} is followed by two layers of PbFCl-type EuFS when sheeted parallel to the (001) plane. Accordingly there are two chemically and crystallographically different europium cations present. One of them (Eu{sup 2+}) is coordinated by eight fluoride anions in a cubic fashion, the other one (Eu{sup 3+}) exhibits a monocapped square antiprismatic coordination sphere with four F{sup -} and five S{sup 2-} anions. Although the structural ordering of the different charged europium cations is plausible, a certain amount of charge delocalization with some polaron activity has to take place, which is suggested by the black color of the title compound. Temperature dependent magnetic susceptibility measurements of Eu{sub 3}F{sub 4}S{sub 2} show Curie-Weiss behavior with an experimental magnetic moment of 8.19(5) mu{sub B} per formula unit and a paramagnetic Curie temperature of 0.3(2) K. No magnetic ordering is observed down to 4.2 K. In accordance with an ionic formula splitting like (Eu{sup II})(Eu{sup III}){sub 2}F{sub 4}S{sub 2} only one third of the europium centers in Eu{sub 3}F{sub 4}S{sub 2} carry permanent magnetic moments. {sup 151}Eu-Moessbauer spectroscopic experiments at 4.2 K show one signal at an isomer shift of -12.4(1) mm/s and a second one at 0.42(4) mm/s. These signals occur in a ratio of 1:2 and correspond to Eu{sup 2+} and Eu{sup 3+}, respectively. The spectra at 78 and 298 K are similar, thus no change in the Eu{sup 2+}/Eu{sup 3+} fraction can be detected. - Graphical abstract: Crystal structure and {sup 151}Eu-Moessbauer spectra of mixed-valent Eu{sub 3}F{sub 4}S{sub 2}.

Grossholz, Hagen; Hartenbach, Ingo [Institut fuer Anorganische Chemie, Universitaet Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart (Germany); Kotzyba, Gunter [Institut fuer Anorganische und Analytische Chemie, Westfaelische Wilhelms-Universitaet Muenster, Corrensstrasse 30, 48149 Muenster (Germany); Poettgen, Rainer, E-mail: pottgen@uni-muenster.d [Institut fuer Anorganische und Analytische Chemie, Westfaelische Wilhelms-Universitaet Muenster, Corrensstrasse 30, 48149 Muenster (Germany); Trill, Henning; Mosel, Bernd D. [Institut fuer Physikalische Chemie, Westfaelische Wilhelms-Universitaet Muenster, Corrensstrasse 30, 48149 Muenster (Germany); Schleid, Thomas, E-mail: schleid@iac.uni-stuttgart.d [Institut fuer Anorganische Chemie, Universitaet Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart (Germany)

2009-11-15T23:59:59.000Z

182

4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-{kappa}B and ERK/MAPK  

Science Conference Proceedings (OSTI)

Catechol estrogens, the hydroxylated metabolites of 17{beta}-estradiol (E{sub 2}), have been considered to be implicated in estrogen-induced carcinogenesis. 4-Hydroxyestradiol (4-OHE{sub 2}), an oxidized metabolite of E{sub 2} formed preferentially by cytochrome P450 1B1, reacts with DNA to form depurinating adducts thereby exerting genotoxicity and carcinogenicity. 4-OHE{sub 2} undergoes 2-electron oxidation to quinone via semiquinone, and during this process, reactive oxygen species (ROS) can be generated to cause DNA damage and cell death. In the present study, 4-OHE{sub 2} was found to elicit cytotoxicity in cultured human mammary epithelial (MCF-10A) cells, which was blocked by the antioxidant trolox. MCF-10A cells treated with 4-OHE{sub 2} exhibited increased intracellular ROS accumulation and 8-oxo-7,8-dihydroxy-2'-deoxyguanosine formation, and underwent apoptosis as determined by poly(ADP-ribose)polymerase cleavage and disruption of mitochondrial transmembrane potential. The redox-sensitive transcription factor nuclear factor {kappa}B (NF-{kappa}B) was transiently activated by 4-OHE{sub 2} treatment. Cotreatment of MCF-10A cells with the NF-{kappa}B inhibitor, L-1-tosylamido-2-phenylethyl chloromethyl ketone, exacerbated 4-OHE{sub 2}-induced cell death. 4-OHE{sub 2} also caused transient activation of extracellular signal-regulated protein kinases (ERK) involved in transmitting cell survival or death signals. A pharmacological inhibitor of ERK aggravated the 4-OHE{sub 2}-induced cytotoxicity, supporting the pivotal role of ERK in protecting against catechol estrogen-induced oxidative cell death.

Chen Zhihua [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Na, Hye-Kyung [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Hurh, Yeon-Jin [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of); Surh, Young-Joon [National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim-dong, Kwanak-ku, Seoul 151-742 (Korea, Republic of)]. E-mail: surh@plaza.snu.ac.kr

2005-10-01T23:59:59.000Z

183

ATF3 Plays a Key Role in Kdo 2-Lipid A-Induced TLR4- Dependent Gene Expression via NF-kB Activation  

E-Print Network (OSTI)

Background: Activating transcription factor 3 (ATF3) is a negative regulator of proinflammatory cytokine expression in macrophages, and ATF3 deficient mice are more susceptible to endotoxic shock. This study addresses the role of ATF3 in the Kdo 2-Lipid A-induced Toll-like receptor 4 (TLR4) signaling pathway in mouse embryonic fibroblasts (MEF). Kdo 2-Lipid A upregulates ATF3 expression in wild type MEF cells and induces both nuclear factor kappa B (NF-kB) and c-Jun N-terminal kinase (JNK) activation via the TLR4 signaling pathway, while neither of these pathways is activated in ATF3-/- MEF cells. Interestingly, in contrast to Kdo 2-Lipid A, the activation of both NF-kB and JNK by TNF-a was normal in ATF3-/- MEF cells. Methodology/Principal Findings: We found that several genes were dramatically upregulated in ATF3+/+ MEF cells in response to Kdo2-Lipid A treatment, while little difference was observed in the ATF3-/- MEF cells. However, we also found that the signal intensities of IkBf in ATF3-/- MEF cells were substantially higher than those in wild type MEF cells upon microarray analyses, and upregulated IkBf expression was detected in the cytosol fraction. Conclusions/Significance: Our findings indicate that ATF3 deficiency affects Kdo 2-Lipid A-induced TLR4 signaling pathways in MEF cells, that it may upregulate IkBf expression and that the high levels of IkBf expression in ATF3-/- cells disrupts Kdo2-Lipid A-mediated signaling pathways.

Eun-young Kim; Hye Young Shin; Joo-young Kim; Dong-gun Kim; Yong-min Choi; Dong-kwon Rhee; You-sun Kim; Sangdun Choi

2010-01-01T23:59:59.000Z

184

The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-{kappa}B and I{kappa}B-{gamma}: Implications for NF-{kappa}B-mediated signal transduction  

SciTech Connect

The NFKB1 gene encodes three proteins of the NF-{kappa}/Rel and I{kappa}B families: p105, p50, and (in mouse) I{kappa}B-{gamma}. We determined the complete genomic structure of human NFKB1. NFKB1 spans 156 kb and has 24 exons with introns varying between 40,000 and 323 bp in length. Although NFKB2, which encodes p100 and p52, also has 24 exons and has a comparable exon-intron structure, it is 20 times shorter than NFKB1. We propose that the long size of NFKB1 is important for transient activation of NF-{kappa}B complexes containing p50. I{kappa}B-{gamma} corresponds to the carboxyl-terminal half of p105. DNA sequence analysis showed that the 3{prime}-end of human intron 11 and the 5{prime}-end of exon 12 of NFKB1 are colinear with the 5{prime}-untranslated region of mouse I{kappa}B-{gamma} cDNA. I{kappa}B-{gamma} is thus likely to be generated by transcription starting within intron 11 and not by alternative splicing of the mouse mRNA encoding p105 and p50. 71 refs., 5 figs., 1 tab.

Heron, E.; Deloukas, P.; van Loon, A.P.G.M. [F. Hoffmann-La Roche Limited, Basel (Switzerland)] [F. Hoffmann-La Roche Limited, Basel (Switzerland)

1995-12-10T23:59:59.000Z

185

Numerical investigation of the pulsed NF3 + H2 chemical laser using a model which includes rotational relaxation and semi-classical laser equations  

DOE Green Energy (OSTI)

Waveforms and population distributions have been calculated by a numerical model and compared with experiment for an electric-discharge-initiated, pulsed NF$sub 3$ + H$sub 2$ chemical laser. The model treats each vibrational- rotational state separately, allowing rotational relaxation between adjacent states as well as vibrational relaxation and lasing according to P-branch selection rules. Calculated waveforms agree with experiment and show several features not seen when rotational equilibrium is assumed: simultaneous lasing on many transitions, cascade behavior, spikes due to laser relaxation oscillations, non-Boltzmann rotational distributions, and ''hole burning'' in the population distributions. The calculations give insight into the physical phenomena governing the shape and duration of the waveforms. The effect of varying certain parameters, relaxation rates, temperature, pressure, and diluents, is studied. Best fit to experimental waveforms is obtained when the rotational relaxation rate and collisional line broadening rate are approximately equal at about 10 times the hard sphere collision rate. The IXION computer code, developed for these calculations, is described in detail. In addition, an analytic model is presented which accounts for major features of the total (all transitions) output waveform of the laser assuming rotational equilibrium, a steady state laser model, and constant temperature. A second computer code, MINOTAR, was developed as a general purpose chemical kinetics code. It verifies the analytic model and extends the results to adiabatic reactions where the temperature varies, and can yield waveforms using the assumptions of rotational equilibrium and a steady state laser. The MINOTAR code, being general, can also be used for chemical kinetics problems such as air pollution and combustion. (auth)

Creighton, J.R.

1975-09-01T23:59:59.000Z

186

Numerical investigation of the pulsed NF3 + H2 chemical laser using a model which includes rotational relaxation and semi-classical laser equations  

SciTech Connect

Waveforms and population distributions have been calculated by a numerical model and compared with experiment for an electric-discharge-initiated, pulsed NF$sub 3$ + H$sub 2$ chemical laser. The model treats each vibrational- rotational state separately, allowing rotational relaxation between adjacent states as well as vibrational relaxation and lasing according to P-branch selection rules. Calculated waveforms agree with experiment and show several features not seen when rotational equilibrium is assumed: simultaneous lasing on many transitions, cascade behavior, spikes due to laser relaxation oscillations, non-Boltzmann rotational distributions, and ''hole burning'' in the population distributions. The calculations give insight into the physical phenomena governing the shape and duration of the waveforms. The effect of varying certain parameters, relaxation rates, temperature, pressure, and diluents, is studied. Best fit to experimental waveforms is obtained when the rotational relaxation rate and collisional line broadening rate are approximately equal at about 10 times the hard sphere collision rate. The IXION computer code, developed for these calculations, is described in detail. In addition, an analytic model is presented which accounts for major features of the total (all transitions) output waveform of the laser assuming rotational equilibrium, a steady state laser model, and constant temperature. A second computer code, MINOTAR, was developed as a general purpose chemical kinetics code. It verifies the analytic model and extends the results to adiabatic reactions where the temperature varies, and can yield waveforms using the assumptions of rotational equilibrium and a steady state laser. The MINOTAR code, being general, can also be used for chemical kinetics problems such as air pollution and combustion. (auth)

Creighton, J.R.

1975-09-01T23:59:59.000Z

187

FS: heat pump water heaters | The Better Buildings Alliance  

NLE Websites -- All DOE Office Websites (Extended Search)

Food Service » Install a heat pump Food Service » Install a heat pump water heaterand reduce water heating energy up to 70% using the commercial heat pump water heater specificat Activities Technology Solutions Teams Lighting & Electrical Space Conditioning Plug & Process Loads Food Service Refrigeration Laboratories Energy Management & Information Systems Public Sector Teams Market Solutions Teams Install a heat pump water heaterand reduce water heating energy up to 70% using the commercial heat pump water heater specification The Food Service team developed a Commercial Heat Pump Water Heater Specification that can be used to reduce water heating energy by 70%. An older, electric resistance water heater (operated in a building with a hot water demand of 500 gallons a day) can cost more than $3,500 each year

188

CEC-500-2010-FS-004 Development and Demonstration of  

E-Print Network (OSTI)

) systems can maximize the solar energy output from a given surface area, while using less photovoltaic Active Micro-Inverters RENEWABLE ENERGY RESEARCH PIER Renewable Energy Research www.energy and electricity generation goals, the use of renewable energy technologies, including solar, must be expanded

189

CEC-500-2010-FS-XXX California Transportation  

E-Print Network (OSTI)

Action Plan for California sets specific biofuels use targets in California to reduce dependence through the production of biofuels by California's agricultural sector. A stronger research and development initiative is necessary for the potential role of biofuels from energy crops to be accurately

190

BGRR FS FINAL - 07-16-04.PDF  

NLE Websites -- All DOE Office Websites (Extended Search)

primary liner system Remove from the two ducts and compact on-site Contaminated metal debris (8.2) Primary liner system debris (880) Exhaust filters (24) Land disposal Land...

191

Report: WR-FS-99-02 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

Office During the Audit of the Department of Energy's Consolidated Fiscal Year 1998 Financial Statements The Government Management Reform Act of 1994 requires that the...

192

Financial Statement: OAS-FS-13-10  

Energy.gov (U.S. Department of Energy (DOE))

Information Technology Management Letter on Audit of The Department of Energy's Consolidated Balance Sheet for Fiscal Year 2012

193

NOAA Technic I R art FS Clrcul Proceedings of  

E-Print Network (OSTI)

to produce 33 t (dry weight) of Spirulina annually. Because of high production costs, Spirulina has for the creeping larvae of abalone. Recently, the production of Spirulina sp. has reached commercial scale advantage of its high carotenoid content (Honma et aI. 1974). In recent years, however, Spirulina has been

194

CEC-500-2010-FS-XXX New Microalgae Fermentation  

E-Print Network (OSTI)

Description This research enabled Solazyme's commercial oil biomanufacturing process to use heterotrophic, cellulosic feedstocks. By the end of this research, Solazyme: · Determined the growth parameters to market. Solazyme's program of research under this Public Interest Energy Research (PIER) grant builds

195

Master Thesis FS 2014 Focus on Energy, Flow  

E-Print Network (OSTI)

, fatigue loads on turbines in wakes increase by up to 80%. To reduce turbine lifecycle costs, computational error analysis of kite-based measurements · Fulfilling validating measurements and measurements in wind of measurements, 20% developing electronic communication routines, 20% in developing software and 30

Daraio, Chiara

196

Audit Report: OAS-FS-13-09  

Energy.gov (U.S. Department of Energy (DOE))

Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2010 Balance Sheet Audit

197

Audit Report: OAS-FS-12-09  

Energy.gov (U.S. Department of Energy (DOE))

Management Letter on the Department of Energy's Isotope Development and Production for Research and Applications Program's Fiscal Year 2009 Balance Sheet Audit

198

Multimodal microscopy with sub-30 fs Yb fiber laser oscillator  

E-Print Network (OSTI)

­3091 (2011). 16. D. Kobat, M. E. Durst, N. Nishimura, A. W. Wong, C. B. Schaffer, and C. Xu, "Deep tissue

Dantus, Marcos

199

NanoFab Tool: Heidelberg DWL-66FS  

Science Conference Proceedings (OSTI)

... High resolution pattern generator for low volume mask ... photomask blanks as well as direct patterning of ... US1 Address: 100 Bureau Drive, Stop 6201 ...

2013-05-12T23:59:59.000Z

200

CEC-500-2010-FS-016 Cumulative Biological Impacts  

E-Print Network (OSTI)

). Solar Technologies (CHE 451) 3 credits Biomechanics of Sport and Exercise (EXSS 323) 4 credits Chemical and science (CHE 445) 4 credits Fundamentals of environmental engineering (ENVE 322) 4 credits Chemical credits Process control (CHE 461) 3 credits Environmental engineering design (ENVE 422) 4 credits

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Audit Report: OAS-FS-10-03  

Energy.gov (U.S. Department of Energy (DOE))

Management Letter on the Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 2009

202

Using FS-ST-FMR for MRAM Research  

Science Conference Proceedings (OSTI)

... Industry planners are concerned that the ubiquitous dynamic random access memory (DRAM) chip, a key component of computers for more than ...

2013-08-14T23:59:59.000Z

203

Master Thesis -FS 2014 Focus on Energy, Flow  

E-Print Network (OSTI)

of a Gas Injection and Measurement System for RIGI Centrifugal compressors are used in power generation. A solution to reach it would be to reduce the speed of sound by changing the gas properties of the working rig with the new gas mixture. (10%) Skills in CAD and LabVIEW are useful. You should be creative

Daraio, Chiara

204

10.1007%2Fs12155-013-9315-6  

NLE Websites -- All DOE Office Websites (Extended Search)

of cellulose synthases, transferases, decarboxy- lases, and epimerases from maize, sorghum, rice, and Ara- bidopsis found in the NCBI unigene database (http:...

205

Three fold system (3FS) for mental health domain  

Science Conference Proceedings (OSTI)

Along with an increase in the number of mentally ill people, research into all aspects of mental health has increased in recent years. In all disciplines information is the key to success but major problems adversely affect the efficiency and effectiveness ... Keywords: data mining, health information systems, intelligent information retrieval, mental health research, ontology-based multi-agent systems

Maja Hadzic; Roberta Ann Cowan

2007-11-01T23:59:59.000Z

206

High-loop perturbative renormalization constants for Lattice QCD (II): three-loop quark currents for tree-level Symanzik improved gauge action and n_f=2 Wilson fermions  

E-Print Network (OSTI)

Numerical Stochastic Perturbation Theory was able to get three- (and even four-) loop results for finite Lattice QCD renormalization constants. More recently, a conceptual and technical framework has been devised to tame finite size effects, which had been reported to be significant for (logarithmically) divergent renormalization constants. In this work we present three-loop results for fermion bilinears in the Lattice QCD regularization defined by tree-level Symanzik improved gauge action and n_f=2 Wilson fermions. We discuss both finite and divergent renormalization constants in the RI'-MOM scheme. Since renormalization conditions are defined in the chiral limit, our results also apply to Twisted Mass QCD, for which non-perturbative computations of the same quantities are available. We emphasize the importance of carefully accounting for both finite lattice space and finite volume effects. In our opinion the latter have in general not attracted the attention they would deserve.

Brambilla, Michele

2013-01-01T23:59:59.000Z

207

The human transcription factor CP2 (TFCP2), a component of the human {gamma}-globin stage selector protein, maps to chromosome region 12q13 and is within 250 kb of the NF-E2 gene  

SciTech Connect

The transcription factor CP2{sup 2} has been shown to bind to several cellular and viral promoters as a homodimer. More recently, we have demonstrated that CP2 can form a heterodimer with a 45-kDa partner protein to form the stage selector protein complex (SSP). This complex binds to a proximal {gamma}-globin promoter regulatory element, the stage selector element (SSE), which appears to be involved in the competitive silencing of the {beta}-gene in the fetal stage of erythropoiesis. Similar SSP-like binding sites have been identified in the {beta}-globin promoter and regulatory elements of the {beta}-globin locus control region (LCR). The importance of the SSP complex is further emphasized by the fact that the chicken stage selector protein, NF-E4, which has been implicated in the competitive silencing of the chicken {epsilon}-globin gene, is the avian homologue of CP2. The purpose of this study is to map human CP2 genomically and define its relationship to previously identified loci. 9 refs., 1 fig.

Cunningham, J.M.; Tran, N.; Valentine, M. [St. Jude Children`s Research Hospital, Memphis, TN (United States)] [and others

1995-11-20T23:59:59.000Z

208

Mechanical Properties of Advanced NF616 Steel  

Science Conference Proceedings (OSTI)

... of TIG Welded and Laser-surface Melted SUS 304 for Nuclear Power Plants ... Statistics of Grain Boundary Crystallography in Surrogates for Oxide Nuclear...

209

10.1007%2Fs10570-013-0018-0.pdf  

NLE Websites -- All DOE Office Websites (Extended Search)

Simulation Simulation of a cellulose fiber in ionic liquid suggests a synergistic approach to dissolution Barmak Mostofian * Jeremy C. Smith * Xiaolin Cheng Received: 24 April 2013 / Accepted: 1 August 2013 Ó Springer Science+Business Media Dordrecht (outside the USA) 2013 Abstract Ionic liquids dissolve cellulose in a more efficient and environmentally acceptable way than conventional methods in aqueous solution. An under- standing of how ionic liquids act on cellulose is essential for improving pretreatment conditions and thus detailed knowledge of the interactions between the cations, anions and cellulose is necessary. Here, to explore ionic liquid effects, we perform all-atom molecular dynamics simulations of a cellulose microfibril in 1-butyl-3- methylimidazolium chloride and analyze site-site inter- actions and cation orientations at the solute-solvent interface. The

210

FCM_FS: A Simultaneous Clustering and Feature Selection Model for Classification  

Science Conference Proceedings (OSTI)

Fuzzy relational classifier (FRC) is the recently proposed two-step nonlinear classifiers, which effectively integrates the formed clusters and the given classes. However, FRC can not copy with the influence of those irrelevant or redundant features. ... Keywords: FCM, Classification, Feature Selection, Enhanced Fuzzy Relational Classifier (EFRC)

Ming Yang; Jing Song; Gen-lin Ji

2009-03-01T23:59:59.000Z

211

Nearfield Imaging of Plasmonic Nano-devices at 10 nm and 10 fs  

Science Conference Proceedings (OSTI)

Individual features of single and composite nano-antennas [4,5] such as termination reflection phase and unidirectional coupling efficiency are revealed ,...

212

CEC-500-2010-FS-XXX Natural Gas Engine and  

E-Print Network (OSTI)

. to develop and optimize a sparkignited CNG Powered Refuse Truck Photo Credit: Cummings Westport, Inc. 11.9 liter CNG engine suitable for refuse and other vocational Class 8 applications. The engine conventional CNG engine to a more efficient and higher performance engine, and integrate it into a refuse

213

This work addresses the high-rate session scheduling problem in Fractional Lambda Switching (FS)  

E-Print Network (OSTI)

Multiplexing (such as SONET/SDH) and Wavelength Division Multiplexing (WDM). Yet, Non-Immediate Forwarding (NIF-rate NIF session. An efficient scheduling algorithm, eSSM, is proposed to explore all possibilities in two modes: (1) immediate forwarding (IF) or (2) non-immediate forwarding (NIF). NIF is more

Baldi, Mario

214

Slide12 fs | OSTI, US Dept of Energy, Office of Scientific and...  

Office of Scientific and Technical Information (OSTI)

Go to Videos Loading... Stop news scroll Most Visited Adopt-A-Doc DOE Data Explorer DOE Green Energy DOepatents DOE R&D Accomplishments .EDUconnections Energy Science and...

215

Final Report for LDRD Project 02-FS-009 Gigapixel Surveillance Camera  

Science Conference Proceedings (OSTI)

The threats of terrorism and proliferation of weapons of mass destruction add urgency to the development of new techniques for surveillance and intelligence collection. For example, the United States faces a serious and growing threat from adversaries who locate key facilities underground, hide them within other facilities, or otherwise conceal their location and function. Reconnaissance photographs are one of the most important tools for uncovering the capabilities of adversaries. However, current imaging technology provides only infrequent static images of a large area, or occasional video of a small area. We are attempting to add a new dimension to reconnaissance by introducing a capability for large area video surveillance. This capability would enable tracking of all vehicle movements within a very large area. The goal of our project is the development of a gigapixel video surveillance camera for high altitude aircraft or balloon platforms. From very high altitude platforms (20-40 km altitude) it would be possible to track every moving vehicle within an area of roughly 100 km x 100 km, about the size of the San Francisco Bay region, with a gigapixel camera. Reliable tracking of vehicles requires a ground sampling distance (GSD) of 0.5 to 1 m and a framing rate of approximately two frames per second (fps). For a 100 km x 100 km area the corresponding pixel count is 10 gigapixels for a 1-m GSD and 40 gigapixels for a 0.5-m GSD. This is an order of magnitude beyond the 1 gigapixel camera envisioned in our LDRD proposal. We have determined that an instrument of this capacity is feasible.

Marrs, R E; Bennett, C L

2010-04-20T23:59:59.000Z

216

Audit report: ER-FS-99-02 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

Operations Office During the Audit Of The Department's Consolidated Fiscal Year 1998 Financial Statements The Government Management Reform Act of 1994 requires that audited...

217

Audit Report: WR-FS-97-03 | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

Flats Field Office During the Audit of the Department's Consolidated Fiscal Year 1996 Financial Statements The Government Management Reform Act of 1994 requires that the...

218

Audit Report: OAS-FS-06-01 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

November 14, 2005 Report o the Department of Energy's Fiscal Year 2005 Consolidated Financial Statements Report o the Department of Energy's Fiscal Year 2005 Consolidated...

219

Audit Report: OAS-FS-08-02 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

November 9, 2007 Report on the Department of Energy's Fiscl year 2007 Consolidated Financial Statements This is to inform you that the audit of the Departments Fiscal Year...

220

Audit Report: OAS-FS-10-01 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

on "Federal Energy Regulatory Commission's Fiscal Year 2009" 1074 Combined report on financial statements (unqualified opinion), internal controls, and compliance and other...

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Audit Report: OAS-FS-12-03 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

November 2, 2011 The Department of Energy's Nuclear Waste Fund's Fiscal Year 2011 Financial Statements The attached report presents the results of the independent certified...

222

Audit Report: OAS-FS-13-05 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

of net cost, changes in net position and budgetary resources. KPMG concluded that the financial statements present fairly, in all material respects, the financial position of...

223

Audit Report: OAS-FS-11-01 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

November 12, 2010 Report on the Department of Energy's Fiscal Year2010 Consolidated Financial Statements This is to inform you that the audit of the Department of Energy's...

224

GreenFS: making enterprise computers greener by protecting them better  

Science Conference Proceedings (OSTI)

Hard disks contain data - frequently an irreplaceable asset of high monetary and non-monetary value. At the same time, hard disks are mechanical devices that consume power, are noisy, and fragile when their platters are rotating. In this paper we demonstrate ... Keywords: backup, continuous data protection, power efficiency

Nikolai Joukov; Josef Sipek

2008-04-01T23:59:59.000Z

225

North Brazil Current Ring Generation and Evolution Observed with SeaWiFS  

Science Conference Proceedings (OSTI)

The earth's largest oceanic rings are formed by the retroflecting North Brazil Current (NBC) near 8N in the western tropical Atlantic. The NBC flows northward across the equator and past the mouth of the Amazon River entraining river-influenced ...

David M. Fratantoni; Deborah A. Glickson

2002-03-01T23:59:59.000Z

226

CEC-500-2011-FS-XXX Assessment of Particulate Matter  

E-Print Network (OSTI)

, which will include a compressed natural gas car. The physical, chemical, and toxicological properties (diesel, biodiesel, gasoline, E85 ethanol), as well as heavyduty vehicle emissions. The systems

227

Audit Report: OAS-FS-13-01 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

FOIA Reports Calendar Year Reports Recovery Act Peer Reviews DOE Directives Performance Strategic Plan Testimony Financial Statements Semiannual Reports Work Plan Mission About...

228

Audit Report: OAS-FS-12-05 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

FOIA Reports Calendar Year Reports Recovery Act Peer Reviews DOE Directives Performance Strategic Plan Testimony Financial Statements Semiannual Reports Work Plan Mission About...

229

Audit Report: OAS-FS-12-06 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

FOIA Reports Calendar Year Reports Recovery Act Peer Reviews DOE Directives Performance Strategic Plan Testimony Financial Statements Semiannual Reports Work Plan Mission About...

230

Audit Report: OAS-FS-12-01 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

FOIA Reports Calendar Year Reports Recovery Act Peer Reviews DOE Directives Performance Strategic Plan Testimony Financial Statements Semiannual Reports Work Plan Mission About...

231

Audit Report: OAS-FS-11-07 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

FOIA Reports Calendar Year Reports Recovery Act Peer Reviews DOE Directives Performance Strategic Plan Testimony Financial Statements Semiannual Reports Work Plan Mission About...

232

Audit Report: OAS-FS-11-06 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

FOIA Reports Calendar Year Reports Recovery Act Peer Reviews DOE Directives Performance Strategic Plan Testimony Financial Statements Semiannual Reports Work Plan Mission About...

233

I The sat (Sl md.re#t IR) inpuFs OyaCIjdo  

E-Print Network (OSTI)

aH a * input cQhrd8&mr: bc;ch ktpm tyva the paeMitv in&rtor to vvhen"b ' is low, the activehDgh outpu? is forced high; when "R " is low, the active-high output is forced low. Although normally the aotive-low output is drs complement of DUAL DTYPE RIP-FLOP e J-K master/slave The duat D-type flip-flop shown in Figura I of two imht D-tr.pe flip-flops with inputs on the left and flipflops: W mn&h w?U sxta mfy for as long as both "8 ' and "R " wo brcl low. The flip-flop will return to some indeterminate state when both " S and "R " go high. FIGURE 2. Four-Bit Bistable Latch input. tion is derived as follows:- The "DC " input has an AND relationship with the "C " input w shown by the subswipted "C". Therefore, Data passas through "Dc" only when "6 ' is active trua- Input "C " is sensitive to transition, or sensitive as shown by:he ed % (dynamic indicator) symbol.- Absence of the polarity indicator on input "C " means that the MORE E level is true. Therefore, ive true on a low-to-hi& tramis# * and when "C " is active true as stated &over data is passed through and active low outputs are by the abseme/presence of tarritvindicator {-P 1. FOUR-BIT BISTABLE LATCH The fourbit bistable latch shown in Figure 2 consists of four independent D-type flip-flops. FFI and FF2 are controlled by the 61 dock input, and FF3 and FF4 are controlled by the C2 clock input. This is evident by the subscripted C1 and C2 on the input data lines. Information present at a data (Dc) input is transferred to the active-high and active-low outputs when the associated clock input is high: the outputs will follow the data as long as the clock remains high. When the clock goes low, the information that was present at the data input when t4e transition occurred is retained at the outputs until the dock returns high. WWW.HPARCHIVE.COM-flops. Inputs to the master section on the left side are controlled by the gate (G) pulse. The gate pulse also controls the state of the coupling transistors (not shown) wh connect the mmw aprd dm

unknown authors

1976-01-01T23:59:59.000Z

234

10.1007%2Fs10570-013-0011-7.pdf  

NLE Websites -- All DOE Office Websites (Extended Search)

mechanism and origin of high activity of cellulase TmCel12A at high temperature: a quantum mechanicalmolecular mechanical study Peng Lian * Hao-Bo Guo * Jeremy C. Smith *...

235

art%253A10.1007%252Fs12155-012-9292-1.pdf  

NLE Websites -- All DOE Office Websites (Extended Search)

is published with open access at Springerlink.com Abstract As a native, low-input crop with high biomass production, switchgrass (Panicum virgatum) has become a favorable...

236

Microsoft Word - Final Report Package Transmittal - FY 2010 FS Management Letter.doc  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Department of Energy Department of Energy Memorandum DATE: December 20, 2010 REPLY TO ATTN OF: IG-322 (A10FN006) SUBJECT: Management Letter on the Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 2010 TO: Chief Financial Officer, CF-1 Attached is the subject letter prepared by KPMG LLP, our contract auditors. The letter contains 23 new findings (see letter, Exhibit A) and 4 repeat findings (see letter, Exhibit B) that were issued during the course of the Fiscal Year 2010 audit of the Department of Energy's (Department) Consolidated Financial Statements. Management generally concurred with and provided planned corrective actions for most of the recommendations listed in the Management Letter and management's comments are included in each finding.

237

Federal Utility Partnership Working Group - Utility Interconnection Panel  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

WORKING GROUP - Utility Interconnection Panel M. Renee Jewell, Program/Energy Manager, & Contracting Officer, Forest Service (reneejewell@fs.fed.us) SCENARIO: Fed Agencies had Solar PV Projects To Connect with Utility in California * United States (US) Forest Service (FS) - 1 small Solar Photovoltaic (PV) project; and - 1 small Renewable project (Solar PV) exporting energy to grid. * U.S. National Park Service (NPS) - 24 Small Solar Photovoltaic projects. * U.S. Dept. of Veterans Affairs (VA) - 6 Renewable generation projects of different sizes. FS Region 5 (California) - Solar Photovoltaic Installations Solar PV Project @ Mono Lake Visitor Center (Inyo NF) Solar PV Project (net exporter) @ San Dimas Technology and Development Center SITUATION - Utility Wanted Feds to Sign Its

238

USFS Humboldt-Toiyabe National Forest | Open Energy Information  

Open Energy Info (EERE)

USFS Humboldt-Toiyabe National Forest USFS Humboldt-Toiyabe National Forest Jump to: navigation, search Name USFS Humboldt-Toiyabe National Forest Short Name Humbolt-Toiyabe NF Parent Organization United States Forest Service Address 1200 Franklin Way Place Sparks, NV Zip 89431 Phone number (775) 331-6444 Website http://www.fs.usda.gov/main/ht References Humboldt-Toiyabe NF Website[1] This article is a stub. You can help OpenEI by expanding it. USFS Toiyabe National Forest is an organization based in Sparks, Nevada, Sparks, Nevada. References ↑ "Humboldt-Toiyabe NF Website" Retrieved from "http://en.openei.org/w/index.php?title=USFS_Humboldt-Toiyabe_National_Forest&oldid=640692" Categories: Government Agencies Stubs What links here Related changes Special pages Printable version

239

Beam Loading Computation for the IDS-NF FFAG  

SciTech Connect

I accumulate the information we have for the current baseline design for a neutrino factory to determine the maximum current we can expect at the final FFAG accelerating stage. I then determine the energy extracted from the RF cavities in the FFAG, and from that determine how much time there must be between bunch trains to restore the energy to the RF cavities so that each bunch train has the same energy at the storage ring. I also estimate the amount of energy variation from the head to the tail of the bunch train.

Berg, J.S.

2011-10-01T23:59:59.000Z

240

CMRR-NF Supplemental EIS Scoping Comments | National Nuclear...  

National Nuclear Security Administration (NNSA)

Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management...

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Audit of Departmental Integrated Standardized Core Accounting System (DISCAS) Operations at Selected Field Sites, AP-FS-97-02  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

AUDIT OF DEPARTMENTAL INTEGRATED STANDARDIZED CORE ACCOUNTING SYSTEM (DISCAS) OPERATIONS AT SELECTED FIELD SITES The Office of Inspector General wants to make the distribution of its reports as customer friendly and cost effective as possible. Therefore, this report will be available electronically through the Internet five to seven days after publication at the following alternative addresses: Department of Energy Headquarters Gopher gopher.hr.doe.gov Department of Energy Headquarters Anonymous FTP vm1.hqadmin.doe.gov

242

Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 1996, CR-FS-97-02  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

DEPARTMENT OF ENERGY DEPARTMENT OF ENERGY OFFICE OF INSPECTOR GENERAL MANAGEMENT REPORT AUDIT OF THE DEPARTMENT OF ENERGY'S CONSOLIDATED FINANCIAL STATEMENTS FOR FISCAL YEAR 1996 The Office of Inspector General wants to make the distribution of its reports as customer friendly and cost effective as possible. Therefore, this report will be available electronically through the Internet five to seven days after publication at the following

243

Data Package of Samples Collected for Hydrogeologic and Geochemical Characterization: 300 Area RI/FS Sediment Cores  

Science Conference Proceedings (OSTI)

This is a data package for sediment samples received from the 300 FF 5 OU. This report was prepared for CHPRC. Between August 16, 2010 and April 25, 2011 sediment samples were received from 300-FF-5 for geochemical studies. The analyses for this project were performed at the 331 building located in the 300 Area of the Hanford Site. The analyses were performed according to Pacific Northwest National Laboratory (PNNL) approved procedures and/or nationally recognized test procedures. The data sets include the sample identification numbers, analytical results, estimated quantification limits (EQL), and quality control data. The preparatory and analytical quality control requirements, calibration requirements, acceptance criteria, and failure actions are defined in the on-line QA plan 'Conducting Analytical Work in Support of Regulatory Programs' (CAW). This QA plan implements the Hanford Analytical Services Quality Assurance Requirements Documents (HASQARD) for PNNL.

Lindberg, Michael J.; Bjornstad, Bruce N.; Lanigan, David C.; Williams, Benjamin D.

2011-05-01T23:59:59.000Z

244

Calibration Evaluation and Radiometric Testing of Field Radiometers with the SeaWiFS Quality Monitor (SQM)  

Science Conference Proceedings (OSTI)

One of the goals of calibration and validation programs supporting ocean color satellites is to produce water-leaving radiances with an uncertainty of 5% in clear-water regions. This objective requires field instruments with a calibration and ...

Stanford B. Hooker; James Aiken

1998-08-01T23:59:59.000Z

245

Final_Tech_Session_Schedule_and_Location.xls  

NLE Websites -- All DOE Office Websites (Extended Search)

Accounting Rules and Accounting Rules and Guidelines for the Forest Sector Richard Birdsey Manager, Global Change Research Program USDA Forest Service May 2005 Greenhouse Gas Accounting Rules and Guidelines for the Forest Sector Mike Amacher (FS-RMRS) Katie Bickel (USDA) Rich Birdsey (FS-NE) Sandra Brown (Winrock Int'l) Marilyn Buford (FS-WO) Dave Chojnacky (FS-RMRS) Nick Crookston (FS-RMRS) Matt Fladeland (NASA) Alex Friend (FS-NC) Emile Gardner (FS-SRS) Christian Giardina (FS-NC) Linda Heath (FS-NE) Cliff Hickman (FS-WO) Bill Hohenstein (USDA) Coeli Hoover (FS-NE) Susan Hummell (FS-PNW) Linda Joyce (FS-RMRS) Ted Leininger (FS-SRS) Chris Maier (FS-SRS) Dave Nowak (FS-NE) Chris Potter (NASA) Greg Reams (FS-SRS) Jim Schmierer (Michigan Tech) Michelle Schoeneberger (FS-RMRS) Ken Skog (FS-FPL) Jim Smith (FS-NE)

246

Report on Matters Identified at Strategic Petroleum Reserve During Audit of Statement of Financial Position, CR-FS-96-03  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

an ASCII-formatted version of a printed an ASCII-formatted version of a printed document. The page numbers in this electronic version may not be in the same order as those in the printed document. The printed document may also contain charts and photographs which are not reproduced in this electronic version. If you require the printed version of this document, contact the Office of Inspector General (IG-1), Department of Energy, 1000 Independence Avenue, SW, Washington, DC, 20585, or call the Office of Inspector General Reports Request Line at (202) 586-2744. U. S. DEPARTMENT OF ENERGY OFFICE OF INSPECTOR GENERAL

247

Report on Matters Identified at the Richland Operations Office During the Audit of the Department's Consolidated Fiscal Year 1996 Financial Statements, WR-FS-97-04  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

REPORT ON MATTERS IDENTIFIED AT THE RICHLAND OPERATIONS OFFICE DURING THE AUDIT OF THE DEPARTMENT S CONSOLIDATED FISCAL YEAR 1996 FINANCIAL STATEMENTS The Office of Inspector General wants to make the distribution of its audit reports as customer friendly and cost effective as possible. Therefore, this report will be available electronically through the Internet five to seven days after publication at the following alternative addresses: Department of Energy Headquarters Gopher gopher.hr.doe.gov

248

Report on Matters Identified at the Rocky Flats Field Office During the Audit of the Department's Consolidated Fiscal Year 1996 Financial Statements, WR-FS-97-03  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

DEPARTMENT OF ENERGY DEPARTMENT OF ENERGY OFFICE OF INSPECTOR GENERAL REPORT ON MATTERS IDENTIFIED AT THE ROCKY FLATS FIELD OFFICE DURING THE AUDIT OF THE DEPARTMENTmS CONSOLIDATED FISCAL YEAR 1996 FINANCIAL STATEMENTS The Office of Inspector General wants to make the distribution of its audit reports as customer friendly and cost effective as

249

100-BC-5 Operable Unit, Batch Leach Analyses and Report for Sediments at RI/FS Wells C7508, C7783, C7784, C7785, and C7787  

SciTech Connect

This is an analytical data report for sediment samples from the 100 BC Operable unit. This report contains the updated dates for samples associated with Hexavalent Chromium/Soil analysis. Between August 24, 2010 and March 3, 2011 sediment samples were received from 100-BC Decision Unit Soil for geochemical studies. The analyses for this project were performed at the 331 building located in the 300 Area of the Hanford Site. The analyses were performed according to Pacific Northwest National Laboratory (PNNL) approved procedures and/or nationally recognized test procedures. The data sets include the sample identification numbers, analytical results, estimated quantification limits (EQL), and quality control data. The preparatory and analytical quality control requirements, calibration requirements, acceptance criteria, and failure actions are defined in the on-line QA plan 'Conducting Analytical Work in Support of Regulatory Programs' (CAW). This QA plan implements the Hanford Analytical Services Quality Assurance Requirements Documents (HASQARD) for PNNL.

Lindberg, Michael J.

2011-04-01T23:59:59.000Z

250

Emissions of PCDD/Fs from municipal solid waste incinerators in China Yuwen Ni, Haijun Zhang, Su Fan, Xueping Zhang, Qing Zhang, Jiping Chen *  

E-Print Network (OSTI)

s t r a c t Gas emission of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD.5% of the total production of the world (Zhang and Zhu, 2006). The lack of landfill sites for the wastes has operated in China (Yan et al., 2006). However, until now there was a lack of detailed information

Columbia University

251

www.ScienceTranslationalMedicine.org 18 January 2012 Vol 4 Issue 117 117fs3 1 Arteriovenous malformations (AVMs) are  

E-Print Network (OSTI)

in the blood vessel endothelial cells of the mouse brain vasculature by admin- istering the drug doxycycline, which rap- idly down-regulates Notch4* expression; removal of doxycycline turns Notch4 sig- naling back

Schaffer, Chris B.

252

Anthropogenic impact on spring bloom dynamics in the Yangtze River Estuary based on SeaWiFS mission 19982010 and MODIS 20032010 observations  

Science Conference Proceedings (OSTI)

Nutrient output from the Yangtze River to the sea has increased dramatically since the 1960s, and over the past 50 years more than 50,000 reservoirs on the Yangtze River basin have had little impact on water discharge, but have drastically reduced the ...

Cheng Chen, Hong Jiang, Yu Zhang

2013-08-01T23:59:59.000Z

253

Audit of The U.S. Department of Energy's Consolidated Statement of Financial Position (as of September 30, 1995), IG-FS-96-01  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

DEPARTMENT OF ENERGY DEPARTMENT OF ENERGY OFFICE OF INSPECTOR GENERAL OFFICE OF AUDIT SERVICES AUDIT OF THE U.S. DEPARTMENT OF ENERGY'S CONSOLIDATED STATEMENT OF FINANCIAL POSITION (As of September 30, 1995)

254

QCD THERMODYNAMICS WITH NF=2+1 NEAR THE CONTINUUM LIMIT AT REALISTIC QUARK MASSES.  

Science Conference Proceedings (OSTI)

We report on our study of QCD thermodynamics with 2 + 1 flavors of dynamical quarks. In this proceeding we present several thermodynamic quantities and our recent calculation of the critical temperature. In order to investigate the thermodynamic properties of QCD near the continuum limit we adopt improved staggered (p4) quarks coupled with tree-level Symanzik improved glue on N{sub t} = 4 and 6 lattices. The simulations are performed with a physical value of the strange quark mass and light quark masses which are in the range of m{sub q}/m{sub s} = 0.05 - 0.4. The lightest quark mass corresponds to a pion mass of about 150 MeV.

UMEDA, T.

2006-07-23T23:59:59.000Z

255

Centr um voor Wi skunde en I nf or mati ca Modelling, AnalysisandSimulation  

E-Print Network (OSTI)

. . . . . . . . . . . . . . . . . . . . . . . . . . 31 iii #12;Contents CAFE Final Report Volume II III Protocols 33 6 Notation and De nitions 35 6.1 and Simulation CAFE project _ Final report volume II Secure protocols and architecture Edited by A. Bosselaers, R;CAFE Project - Final Report Volume II Secure Protocols and Architecture Edited by A. Bosselaers, R

Schoenmakers, Berry

256

e its go right to the heart nf the basis on which  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

gas at the low- est cost-of-service to U.S. consumers-probably below the cost of imported oil and substantially below the costs of other fuel alter- natives. The average price of...

257

Effects of water chemistry on NF/RO membrane structure and performance  

E-Print Network (OSTI)

dioxane. 3.4. Water chemistry: Concentration, pH,4.3.1. Effect of water chemistry on membrane water4.3.2. Effect of water chemistry on EG rejection. ..

Mo, Yibing

2013-01-01T23:59:59.000Z

258

Review of NF-IDS Targets Work Programme Status C. Densham, RAL, 17 November 2009  

E-Print Network (OSTI)

and services ? e) Cost of mercury system ? f) Cost of remote handling systems including shielding required ? g implications for TS shielding CJD, OC, PL (RAL) 4.3.7 Investigate remote handling concepts and cost Dump iv. Time to repair/replace target system, Remote Handling complexity v. Maintenance intervals vi

McDonald, Kirk

259

A Combined NF-IDS and EUROnu Targets Work Programme Chris Densham, Marco Zito, Harold Kirk  

E-Print Network (OSTI)

i. Target system active volume ­ civil engineering, shielding and building costs ii. Remote handling and services e) Cost of mercury system f) Cost of remote handling systems including shielding required g) Any implications for TS TBD #12;shielding 4.3.10 Investigate remote handling concepts, reliability and cost RE

McDonald, Kirk

260

Effects of water chemistry on NF/RO membrane structure and performance  

E-Print Network (OSTI)

water by GAC adsorption, Desalination, 210 (2007) 215-224. [with strong oxidants, Desalination, 176 (2005) 37-45. [49]water RO membranes, Desalination, 235 (2009) 44-57. [19] G.

Mo, Yibing

2013-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Heavy Quark Physics in Nf = 2 QCD ? CP-PACS Collaboration:  

E-Print Network (OSTI)

We present a preliminary analysis of the heavy-heavy spectrum and heavy-light decay constants in full QCD, using a tadpole-improved SW quark action and an RG-improved gauge action on a 16 3 32 lattice with four sea quark masses corresponding to m?/m? ? 0.8, 0.75, 0.7, 0.6 and a ?1 ? 1.3 GeV. We focus particularly on the effect of sea quarks on these observables. 1.

unknown authors

1998-01-01T23:59:59.000Z

262

Insights from reconstructing cellular networks in transcription, stress, and cancer  

E-Print Network (OSTI)

M. & Ghosh, S. Crosstalk in NF-kB signaling pathways. Natcomprehensive characterization of NF-kB family DNA binding.12 CHAPTER 1 NF-kB

Ke, Eugene Yunghung; Ke, Eugene Yunghung

2012-01-01T23:59:59.000Z

263

DOI: 10.1126/science.1164265 , 407 (2009);324Science  

E-Print Network (OSTI)

). Similarly, single nucleotide differences in NF-kB binding sequences determine cofactor specificity for NF-kB

Yamamoto, Keith

264

CtjNf.~1'-1'6....r .:tt33 J C7b/(j7/IS-  

E-Print Network (OSTI)

University Princeton, New Jersey 08540 (Submitted to the XVIII Conf. in High-Energy Physics, Tbilisi, USSR

McDonald, Kirk

265

On the Use of Thermal NF3 as the Fluorination and Oxidation Agent in Treatment of Used Nuclear Fuels  

SciTech Connect

This paper presents results of our investigation on the use of nitrogen trifluoride as the fluorination or fluorination/oxidation agent for use in a process for separating valuable constituents from used nuclear fuels by employing the volatility of many transition metal and actinide fluorides. Nitrogen trifluoride is less chemically and reactively hazardous than the hazardous and aggressive fluorinating agents used to prepare uranium hexafluoride and considered for fluoride volatility based nuclear fuels reprocessing. In addition, nitrogen trifluorides less aggressive character may be used to separate the volatile fluorides from used fuel and from themselves based on the fluorination reactions temperature sensitivity (thermal tunability) rather than relying on differences in sublimation/boiling temperature and sorbents. Our thermodynamic calculations found that nitrogen trifluoride has the potential to produce volatile fission product and actinide fluorides from candidate oxides and metals. Our simultaneous thermogravimetric and differential thermal analyses found that the oxides of lanthanum, cerium, rhodium, and plutonium fluorinated but did not form volatile fluorides and that depending on temperature volatile fluorides formed from the oxides of niobium, molybdenum, ruthenium, tellurium, uranium, and neptunium. We also demonstrated near-quantitative removal of uranium from plutonium in a mixed oxide.

Scheele, Randall D.; McNamara, Bruce K.; Casella, Andrew M.; Kozelisky, Anne E.

2012-05-01T23:59:59.000Z

266

Journal of Membrane Science 256 (2005) 134142 Characterization of novel acid-stable NF membranes before and after  

E-Print Network (OSTI)

studies, artificial aquifer storage and recovery, waterflood surveillance, gas production and CO2. Brady, C. L. V. Aiken, and J. E. Seib- ert, 2007, The 4D mictogravity method for waterflood surveillance

Freger, Viatcheslav "Slava"

267

QCD thermodynamics with $N_f=2+1$ near the continuum limit at realistic quark masses  

E-Print Network (OSTI)

We report on our study of QCD thermodynamics with 2+1 flavors of dynamical quarks. In this proceeding we present several thermodynamic quantities and our recent calculation of the critical temperature. In order to investigate the thermodynamic properties of QCD near the continuum limit we adopt improved staggered (p4) quarks coupled with tree-level Symanzik improved glue on $N_t=4$ and 6 lattices. The simulations are performed with a physical value of the strange quark mass and light quark masses which are in the range of $m_q/m_s=0.05-0.4$. The lightest quark mass corresponds to a pion mass of about 150 MeV.

Takashi Umeda

2006-10-03T23:59:59.000Z

268

Burned Area Emergency Response (BAER) Assessment FINAL Specialist Report GEOLOGIC HAZARDS Station Fire, Angeles N.F.  

E-Print Network (OSTI)

Three USFS BAER Team geologists assessed increased risks from geologic hazards within the 161,000 acre Station Fire. Watershed response to moderate and high severity burned areas will depend on storm intensity and duration, but is likely to be threatening to life, property and natural resources, and costly. Even small storms have a high to severe relative hazard rating for dangerous debris flows across most of the burned area. Most treatments to reduce debris flow risk were deemed not feasible, not effective, and cost prohibitive. Rockfall, debris slides and dry ravel will add additional hazard and sediment bulk to flood flows. Debris basins will fill quickly, and could overtop and damage downstream communities and infrastructure. Debris storage sites are lacking. Abandoned mines are exposed and add additional hazards. Treatment options are few, and warning systems and public education are critical.

Jerry Degraff Geologist; Sierra N. F; Jonathan Yonni; Schwartz Geologist; Angeles N. F

2009-01-01T23:59:59.000Z

269

Low level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts  

E-Print Network (OSTI)

Despite over forty years of investigation on low-level light therapy (LLLT), the fundamental mechanisms underlying photobiomodulation remain unclear. In this study, we isolated murine embryonic fibroblasts (MEF) from ...

Hamblin, Michael R.

270

NMR studies of the transcriptional inhibitor I kappa B alpha and its interaction with the transcription factor NF kappa B  

E-Print Network (OSTI)

correction of random coil NMR chemical shifts. J Am Chem Socproteins by multidimensional NMR. Biochemistry Bax, A. ,ensemble interpretation of NMR dipolar couplings without

Cervantes, Carla F.

2010-01-01T23:59:59.000Z

271

KT McDonald IDS-NF Plenary Meeting (Glasgow) Apr 19, 2012 1 The High-Power-Target System  

E-Print Network (OSTI)

Cryogenics Diagnostics Controls and Interlocks Health and Safety Mechanical Decommissioning Remote Handling and Hot Cells ######## UScaled from LBNE Buildings, tunnels and Infrastructure ######## Scaled from LBNE,405,475 1.06.06 - Target Utility Systems 10,730,099 1.06.07 - Remote Handling Systems 14,348,362 1

McDonald, Kirk

272

Resilience of Alaska's boreal forest to climatic F.S. Chapin III, A.D. McGuire, R.W. Ruess, T.N. Hollingsworth, M.C. Mack,  

E-Print Network (OSTI)

that are disproportionately important relative to their biomass) or dominant species, including white spruce, alder, Sphagnum biomass and palatability) (Kielland et al. 2006). These changes indirectly reduce recruitment of white spruce (Angell and Kielland 2009). Although the data record is too short and the connections to climate

McGuire, A. David

273

FS1112 / Fsica 2 Septiembre-Diciembre 2012 Prof. Carlos Vsquez CARNET NOMBRE P1/30 P2/35 P3/35 DEF/100 DEF/5  

E-Print Network (OSTI)

Guédez Elmo Bell-Smythe Andrea Gruber Sofía Parada Luigibeth Ríos Rafael Zerpa Luisana Balbi Isaías Bravo

Vásquez, Carlos

274

Report on Matters Identified at the Richland Operations Office During the Audit of the Department's Consolidated Statement of Financial Position as of September 30, 1995, WR-FS-96-01  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

DEPARTMENT OF ENERGY DEPARTMENT OF ENERGY OFFICE OF INSPECTOR GENERAL REPORT ON MATTERS IDENTIFIED AT THE RICHLAND OPERATIONS OFFICE DURING THE AUDIT OF THE DEPARTMENTmS CONSOLIDATED STATEMENT OF FINANCIAL POSITION AS OF SEPTEMBER 30, 1995

275

Lake Roosevelt Fisheries Evaluation Program : Limnological and Fisheries Monitoring Annual Report 1999.  

DOE Green Energy (OSTI)

The Grand Coulee Dam was constructed in 1939 without a fish ladder, which eliminated steelhead (Onchorhynchus mykiss), chinook salmon (O. twshwastica), coho salmon (O. kisutch) and sockeye salmon (O. nerka) from returning to approximately 1,835 km (1,140 miles) of natal streams and tributaries found in the upper Columbia River Drainage in the United States and Canada. The Pacific Northwest Electric Power Planning and Conservation Act of 1980 gave the Bonneville Power Administration (BPA), the authority and responsibility to use its legal and financial resources, 'to protect, mitigate, and enhance fish and wildlife to the extent affected by the development and operation of any hydroelectric project of the Columbia River and its tributaries. This is to be done in a manner consistent with the program adopted by the Northwest Power Planning Council (NWPPC), and the purposes of the Act' (NWPPC, 1987). With the phrase 'protect, mitigate and enhance', Congress signaled its intent that the NWPPC's fish and wildlife program should do more than avoid future hydroelectric damage to the basin's fish and wildlife. The program must also counter past damage, work toward rebuilding those fish and wildlife populations that have been harmed by the hydropower system, protect the Columbia Basin's fish and wildlife resources, and mitigate for harm caused by decades of hydroelectric development and operations. By law, this program is limited to measures that deal with impacts created by the development, operation and management of hydroelectric facilities on the Columbia River and its tributaries. However, off-site enhancement projects are used to address the effects of the hydropower system on fish and wildlife (NWPPC 1987). Resident game fish populations have been established in Franklin D. Roosevelt Lake, the reservoir behind Grand Coulee Dam, since the extirpation of anadromous fish species. The resident game fish populations are now responsible for attracting a large percentage of the recreational visits to the region. An increase in popularity has placed Lake Roosevelt fifth amongst the most visited State and Federal parks in Washington. Increased use of the reservoir prompted amplified efforts to enhance the Native American subsistence fishery and the resident sport fishery in 1984 with hatchery supplementation of rainbow trout (O. mykiss) and kokanee salmon (O. nerka). This was followed by the formation of the Spokane Tribal Lake Roosevelt Monitoring Project (LRMP) in 1988 and later by formation of the Lake Roosevelt Data Collection Project in 1991. The Lake Roosevelt Data Collection Project began in July 1991 as part of the BPA, Bureau of Reclamation, and U.S. Army Corps of Engineers System Operation Review process. This process sought to develop an operational scenario for the federal Columbia River hydropower system to maximize the in-reservoir fisheries with minimal impacts to all other stakeholders in the management of the Columbia River. The Lake Roosevelt Monitoring/Data Collection Program (LRMP) is the result of a merger between the Lake Roosevelt Monitoring Program (BPA No. 8806300) and the Lake Roosevelt Data Collection Project (BPA No. 9404300). These projects were merged in 1996 forming the Lake Roosevelt Monitoring Program (LRMP), which continues the work historically completed under the separate projects. The LRMP has two main goals. The first is to develop a biological model for Lake Roosevelt that will predict in-reservoir biological responses to a range of water management operational scenarios, and to develop fisheries and reservoir management strategies accordingly. The model will allow identification of lake operations that minimize impacts on lake biota while addressing the needs of other interests (e.g. flood control, hydropower generation, irrigation, and downstream resident and anadromous fisheries). Major components of the model will include: (1) quantification of entrainment and other impacts to phytoplankton, zooplankton and fish caused by reservoir drawdowns and low water retention times; (2) quantification

McLellan, Holly; Lee, Chuck; Scofield, Ben; Pavlik, Deanne

1999-08-01T23:59:59.000Z

276

Impossible Diplomacies: Japanese American Literature from 1884 to 1938  

E-Print Network (OSTI)

XIP FOUFSFE UIF 6OJUFE 4UBUFT UFO ZFBST B?FS UIF JOTUJUVUJPOB?FS TPKPVSOT PG UISFF UP UFO ZFBST ?F EPDVNFOUBSZ SFDPSETXIP FOUFSFE UIF 6OJUFE 4UBUFT UFO ZFBST B?FS UIF JOTUJUVUJPO

Leong, Andrew Way

2012-01-01T23:59:59.000Z

277

Interatomic Potentials Repository Project  

Science Conference Proceedings (OSTI)

... EAM/FS setfl, Ti.eam.fs, This conversion was performed from GJ Ackland's parameters by MI Mendelev (Ames National Laboratory). ...

2013-07-06T23:59:59.000Z

278

The non-canonical NFkappaB pathway modulates inflammatory signaling by the canonical NFkappaB pathway  

E-Print Network (OSTI)

Nomenclature Initial mM Location IkBa IkBa IkBa:NF-kBIkBa:NF-kB IkBa:IKKIkBa:IKK:NF-kB IkBa mRNA IkBb IkBb IkBb:NF-kB IkBb:NF-?B

Shih, Feng-Sheng

2011-01-01T23:59:59.000Z

279

PROVABLY CONVERGENT COORDINATE DESCENT IN STATISTICAL TOMOGRAPHIC RECONSTRUCTION  

E-Print Network (OSTI)

substitution (ICD/FS), has guaranteed global convergence in addition to the computational e#ciency of ICD/NR. The ICD/FS method works by approximating the log likelihood at each pixel by an alternative quadratic a modified ICD algorithm which we call ICD functional substitution (ICD/FS). The ICD/FS algorithm locally

280

PROVABLY CONVERGENT COORDINATE DESCENT IN STATISTICAL TOMOGRAPHIC RECONSTRUCTION  

E-Print Network (OSTI)

substitution (ICD/FS), has guaranteed global convergence in addition to the computational efficiency of ICD/NR. The ICD/FS method works by approximating the log likelihood at each pixel by an alternative quadratic a modified ICD algorithm which we call ICD functional substitution (ICD/FS). The ICD/FS algorithm locally

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Curcumin: A Review of Anti-Cancer Properties and Therapeutic Activity in Head & Neck Squamous Cell Carcinoma  

E-Print Network (OSTI)

Curcumin Inhibition of NF-kB activation, Suppression ofand other angionegic decreased NF-kB activation factors, Up-of transcription factor NF-kB is suppressed by curcumin (

Wilken, Reason; Veena, Mysore S; Wang, Marilene B; Srivatsan, Eri S

2011-01-01T23:59:59.000Z

282

Mitochondrial Protein Influx in Low-dose Radiation-mediated Radioprote...  

NLE Websites -- All DOE Office Websites (Extended Search)

radioprotection via activation of the prosurvival network of factor NF-kappa B (NF-kB). We have reported that blocking NF-kB activation is able to inhibit 10cGy x-ray-...

283

Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor  

E-Print Network (OSTI)

1 activity suppresses NF-kB-dependent gene transcription andinhibition suppresses NF-kB- dependent gene transcription inof PARP inhibitors to block NF-kB - mediated inflammatory

2012-01-01T23:59:59.000Z

284

The HB22.7 Anti-CD22 Monoclonal Antibody Enhances Bortezomib-mediated Lymphomacidal Activity in a Sequence Dependent Manner  

E-Print Network (OSTI)

the accumulation of NF-kB [3,4], increased ROS generation [via inhibition of NF-kB activation [29]. Interestingly,by bortezomib also inhibits NF-kB activation [3,4], which in

2011-01-01T23:59:59.000Z

285

Particulate Matter in Polluted Air May IncreaseBiomarkers of Inflammation in Mouse Brain  

E-Print Network (OSTI)

sample and unlabelled NF-kB consensus oligonu- cleotide, NSCendothelial cells: role of NF-kB activation. J Immunol 2001;EN, Krappmann D, Scheidereit C. NF-kB and the innate immune

Bondy, Stephen Bondy C

2005-01-01T23:59:59.000Z

286

Type I Interferon is Not Just for Viruses: Cytosolic Sensing of Bacterial Nucleic Acids  

E-Print Network (OSTI)

the nucleus and assemble with NF-kB and other transcriptionactivation of IRF3/7, NF-kB, and MAP kinases (Yoneyama andtype I IFNs primarily via NF-kB, which synergizes with other

Monroe, Kathryn McGee

2011-01-01T23:59:59.000Z

287

Advances in computational mass spectrometry : phosphoprotoemics and proteogenomics  

E-Print Network (OSTI)

and phosphorylation mediated NF-KB activiation. Four histoneto be activated, or relay the signal. In NF-KB signaling, atranscription factor (NF-KB) is held inactive outside the

Payne, Samuel Harris

2008-01-01T23:59:59.000Z

288

Discovery and characterization of the mechanisms of a vaccinia viral Bcl-2 homolog, F1L, on Inhibition of caspase-9 and NLRP1  

E-Print Network (OSTI)

a stably integrated NF-kB-driven secreted embryonic alkalineprior to VACV infection. NF-kB activation in THP-1-Bluecells (ATCC; InvivoGen), NF-kB activation was evaluated by

Yu, Chi Wang

2010-01-01T23:59:59.000Z

289

Mechanisms of regulation in the interferon factor 3 (IRF- 3) pathway  

E-Print Network (OSTI)

gene induction, whereas NF-kB- dependent gene inductioncytokines through the NF-kB pathway 4 , hinting at theprotein) and leads to NF-kB activation 2 . This pathway is

Limmer, Kirsten

2008-01-01T23:59:59.000Z

290

Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?  

E-Print Network (OSTI)

and one of the key factors implicated has been NF-kB [78].Nuclear translocation of NF-kB is associated withSong et al. inhibited NF-kB selectively in the endothelium

2011-01-01T23:59:59.000Z

291

Effects of melatonin and age on gene expression in mouseCNS using microarray analysis  

E-Print Network (OSTI)

gene contains an activation site for NF-kB (Cowland et al. ,and levels of activated NF-kB increase in murine cortex withThus, increased levels of NF-kB activation in the aged brain

Bondy, Stephen Bondy C

2007-01-01T23:59:59.000Z

292

Sumoylation strategies in regulated repression by nuclear receptors and in function of tumor metastasis suppressor genes  

E-Print Network (OSTI)

links gene expression by NF-kB and ?-amyloid precursorinteracts with and inhibits NF-kB in human colon and breastby KAI1. Since KAI1 is a NF-kB target gene, its message

Cai, Ling

2008-01-01T23:59:59.000Z

293

Activation of nucleic acid-sensing Toll-like receptors requires cleavage by endolysosomal proteases: a mechanism to avoid autoimmunity  

E-Print Network (OSTI)

a) RAW cells expressing an NF-kB luciferase reporter wereTRIF to induce production of NF-kB elicited transcripts andand a plasmid encoding an NF-kB luciferase reporter (with 5

Ewald, Sarah Elisabeth

2010-01-01T23:59:59.000Z

294

Self/Non-self Discrimination by Toll-like Receptor 9  

E-Print Network (OSTI)

cells stably expressing a NF-kB luciferase reporter and thewith LPS or CpG. Bottom, NF-kB luciferase activity measuredcells stably expressing a NF-kB luciferase reporter and TLR9

Mouchess, Maria Luz

2011-01-01T23:59:59.000Z

295

Plant and animal sensors of conserved microbial signatures.  

E-Print Network (OSTI)

a nuclear factor kB (NF-kB) re- sponse, is a key transducerof one human TLR induced NF-kB activation in mammaliansee SOM). Plants do not have NF-kBrelated transcrip- tion

Ronald, Pamela C; Beutler, Bruce

2010-01-01T23:59:59.000Z

296

Molecular mechanisms of ligand-dependent repression by the estrogen receptor and derepression by inflammatory signaling  

E-Print Network (OSTI)

links gene expression by NF-kB and b-amyloid precursorsuch as Receptor Activator of NF-kB (RANK), p75 neurotrophinby the p50 ho- modimer of NF-kB DNA binding factors by

Bourk, Eliot Michael

2010-01-01T23:59:59.000Z

297

Protein Kinase CK2 Regulates Cytoskeletal Reorganization during Ionizing Radiation-Induced Senescence of Human Mesenchymal Stem Cells  

E-Print Network (OSTI)

cytokines/chemokines are NF- kB responsive genes. These dataand suggested the possibility of NF-kB activation leadingto secretion of NF-kB responsive chemokines. Cytoskeleton

Wang, Daojing

2010-01-01T23:59:59.000Z

298

Evolution of the Oligopeptide Transporter (OPT) family  

E-Print Network (OSTI)

evaluation. Name Publication NF-kB Tian et al. 2005a 173expressed mutant IkB blocking NF-kB signaling (labeled based selection in (a) NF-kB dataset, (b) ALL dataset, (c)

Gomolplitinant, Kenny Matee

2010-01-01T23:59:59.000Z

299

Toll-like Receptor Signaling and its Effects on Microbial Pathogenesis  

E-Print Network (OSTI)

of transcription factors (NF-kB, AP-1, IRFs) that coordinatestably expressing an NF-kB- luciferase reporter construct.in robust induction of NF-kB, which we attributed to

Arpaia, Nicholas

2011-01-01T23:59:59.000Z

300

Sample-Specific Cancer Pathway Analysis Using PARADIGM  

E-Print Network (OSTI)

cation of response to QNZ (an NF-KB inhibitor) in the breastfor the combination of QNZ (an NF-KB inhibitor) and E2F3.studies have shown that NF-KB may activate E2F family

Benz, Stephen Charles

2012-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Trichoepithelioma  

E-Print Network (OSTI)

that negatively regulates NF-kB activation by TNFR familycomponent proteins in the NF-kB and JNK signaling pathways.regulate the cytokine-induced NF-kB pathway for cellular

Johnson, Hillary; Robles, Mirin; Kamino, Hideko; Walters, Ruth F; Lee, Arnold; Sanchez, Miguel

2008-01-01T23:59:59.000Z

302

Computational tools based on energy landscape theory to predict structurally diverse ensembles of transcription factors  

E-Print Network (OSTI)

E. (2004) Thermodynamics and kinetics of the nf-kb/ikband nf-kb/dna interactions, Biophysical Journal 86, 513a. [

Ltzer, Joachim

2007-01-01T23:59:59.000Z

303

Metabolic Regulation by Lipid Activated Receptors  

E-Print Network (OSTI)

of iKB, which limits Nf-KB signaling(31, 32). PPAR ?VCAM expression through nf-kb and AP1 signaling when taken

Ruby, Maxwell A.

2010-01-01T23:59:59.000Z

304

A High-throughput Screening Approach Identifies Selective Regulators of Il12b Transcription  

E-Print Network (OSTI)

TLR4, in contrast to NF-kB and AP-1, whose activities aresignaling pathways, such as NF-kB and MAP kinase pathways,

Doty, Kevin Richard

2012-01-01T23:59:59.000Z

305

Analysis of Alzheimer's disease severity across brain regions by topological analysis of gene co-expression networks  

E-Print Network (OSTI)

in CF airways Transcription NF-kB signalling pathways Immunesilencing NGF activation of NF-kB EC-MTG Cytoskeleton

Ray, Monika; Zhang, Weixiong

2010-01-01T23:59:59.000Z

306

Shadow Enhancers Provide Precision and Robustness for the Patterning of the Precellular Drosophila Embryo  

E-Print Network (OSTI)

related to mammalian NF-kB. Dorsal controls DV patterningfactor related to mammalian NF-kB (Rushlow et al. 1989; Roth

Perry, Michael W.

2011-01-01T23:59:59.000Z

307

Structural Studies of Calcium/Calmodulin Depenedent Protein Kinase II Activation  

E-Print Network (OSTI)

activation. For example, NF-kB and Ras have been shown toet al. , 2005), and the NF-kB pathway (Dolmetsch et al. ,

Chao, Luke H.

2010-01-01T23:59:59.000Z

308

Pancreatitis and pancreatic cancer in two large pooled casecontrol studies  

E-Print Network (OSTI)

released during pancreatitis, NF-KB, IL-8, COX-2, and TNF-54]. The involvement of NF-KB is of particular interest as

Bracci, Paige M.; Wang, Furong; Hassan, Manal M.; Gupta, Samir; Li, Donghui; Holly, Elizabeth A.

2009-01-01T23:59:59.000Z

309

Anakinra-responsive lichen planus in a woman with Erdheim-Chester disease: a therapeutic enigma  

E-Print Network (OSTI)

cyclosporine A on TLRA/NF-kB signaling pathway activation inof the pro-inflammatory, NF-kB-dependent cytokines: TNF-

Cohen, Philip R; Kurzrock, Razelle

2014-01-01T23:59:59.000Z

310

Conference Highlights of the 15th International Conference on Human Retrovirology: HTLV and Related Retroviruses,4-8 June 2011, Leuven, Gembloux, Belgium  

E-Print Network (OSTI)

subcellular localization and NF-kB activation. RetrovirologyTax sumoylation in Tax-induced NF-kB activation in T cells.

2011-01-01T23:59:59.000Z

311

NK1 (substance P) receptor  

E-Print Network (OSTI)

nuclear factor- kappaB (NF-kB) and leads to the productionits expression is controlled by NF-kB (Patel et al. 2005;

Goldsmith, Laura E; Kwatra, Madan M

2012-01-01T23:59:59.000Z

312

Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress  

E-Print Network (OSTI)

Signaling pathway: Nrf2 MAPK NF-kB Genetic response:ARE AP NF-kB Mitochondrial perturbation PT pore Figure 4

Araujo, Jesus A; Nel, Andre E

2009-01-01T23:59:59.000Z

313

Epidermal growth factor (EGF)-mediated DNA-binding activity of AP-1 is attenuated in senescent human epidermal keratinocytes  

E-Print Network (OSTI)

of microtubes activated NF-kB. J Cell Biol 1995: 128: 1111regulation of wound healing? NF-kB activation in cultured

Shi, B; Isseroff, R R

2005-01-01T23:59:59.000Z

314

Host factor regulation of Toxoplasma gondii growth and differentiation  

E-Print Network (OSTI)

has been shown that the NF-kB subunit p65 is phosphorylatedas a consequence of NF-kB signaling upon parasite

Weilhammer, Dina

2010-01-01T23:59:59.000Z

315

I  

Office of Legacy Management (LM)

(gj' z,r' (gj' z,r' I 3 CEISTRAL F;LES O+ 2g I y * ,;r" x(-J,, r;:, i, :*.s- > _ !, ;I'"( 1' . 5; y 0 $ 3 1 10 tiC0 P .' y lT <-.$--,r.:+s ; a 0 :.9fS .Yw (' t i 1 7, T :., r*> ;< ' , J;! P' ,.;,. y--T;' ; j;.z,,:;, I, -5 ' ir' Ab ,I,: ,;.,.&.. .*. -wrv . i -rs-ab"=-- . ' J.' & :,' JZFi> :;<; of% 1 .+ ,, .,i:.s this ~~3s tc ;rovi.tie IieGth ,mZ safety cover age &iX i?Jg 8 .I; 3 5 ,j of -'-?- ic ;: F?qi:>::J.iy; - .,.C + zle..~tr-o=~3~~e~ii;:zL . i ',.:' ~~ -',~~ 5 ?: ~i:,~ ,~*~i' , - . _- (^:(-$cFYJs ;:.j' _I ,:L' ::,J :a ;X:C I, i&l;_:< T&Y- 1~3 S V-m w*-.z.;-ece*-s-u A-wII-=_u_ y??le T-' .nf' " Ij.' t,L do. _. -3 of ;~.~..-.,;' I:r:~-,c:hc:dca-T. xz::?&l igq ~.irnitLXl

316

Z. Geomorph. N.F. Suppl.-Vol.146 235-251 Berlin Stuttgart November 2006 Geologic Impacts of the 2004 Indian OceanTsunami on Indonesia,  

E-Print Network (OSTI)

of the 2004 Indian OceanTsunami on Indonesia, Sri Lanka, and the Maldives Bruce M. Richmond, Bruce E in the eastern Indian Ocean near northern Sumatra, Indonesia.The resulting tsunami was measured globally and had.1) with an epicenter located under the seafloor in the eastern Indian Ocean near northern Sumatra, Indonesia

317

PI3 Kinase Signals BCR-Dependent Mature B Cell Survival  

E-Print Network (OSTI)

and BAFF-R signal B cellsurvival? UponBAFFengagement,theBAFF-R signalsmainly through the alternative NF-kB can activate the canonical NF-kB signaling pathway and mature B cells require canonical NF-kB signals) to propose a model in which mature B cell survival is based on an NF-kB-mediated crosstalk between BCR

318

Presence of Terminal EPIYA Phosphorylation Motifs in Helicobacter pylori CagA Contributes to IL-8 Secretion,  

E-Print Network (OSTI)

Ba phosphorylation and confirmed CagA involvement in NF-kB activation. Furthermore, we observed that presence of EPIYA-C functional phosphorylation motifs contributed to NF-kB activation. NF-kB upstream signaling-/- mouse embryonic fibroblasts (MEFs) failed to induce NF-kB activity, unlike the respective control MEFs

319

S:\VM3\RX97\TBL_LIST.WPD  

U.S. Energy Information Administration (EIA) Indexed Site

Million U.S. Households, 1997 Housing Unit Characteristics RSE Column Factor: Total Four Most Populated States RSE Row Factors New York California Texas Florida 0.4 1.1 1.1 1.2 1.7 Total .............................................................. 101.5 6.8 11.5 7.0 5.9 NF Census Region and Division Northeast ..................................................... 19.7 6.8 -- -- -- NF New England ............................................. 5.3 Q -- -- -- NF Middle Atlantic ........................................... 14.4 6.8 -- -- -- NF Midwest ....................................................... 24.1 -- -- -- -- NF East North Central ..................................... 16.9 -- -- -- -- NF West North Central .................................... 7.2 -- -- -- -- NF South ...........................................................

320

Audit of the Department of Energy's Consolidated Financial Statements...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Consolidated Financial Statements for Fiscal Year 1996, CR-FS-97-02 Audit of the Department of Energy's Consolidated Financial Statements for Fiscal Year 1996, CR-FS-97-02 Audit of...

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Page not found | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

audit-report-ig-0589 Download Audit Report: OAS-FS-11-06 Department of Energy Isotope Program's Fiscal Year 2007 http:energy.govigdownloadsaudit-report-oas-fs-11-06...

322

Cu  

Science Conference Proceedings (OSTI)

... EAM/FS setfl, Mendelev_Cu2_2012.eam.fs, This file was provided by Mikhail Mendelev (Ames Laboratory) and posted with his permission on 25 Jul ...

2013-07-06T23:59:59.000Z

323

Flux-rms relation in solar radio bursts  

Science Conference Proceedings (OSTI)

Apr 21, 2002 ... dio bursts is clearly different from that for the FS part. The former shows a curve-

324

Technical Report Documentation Page 1. Report No.  

E-Print Network (OSTI)

...........................................................................113 Figure 6.11 Bottom Surface of Specimen FS-2 after Strengthening with the CFRP Wet-Layup System

Texas at Austin, University of

325

Property:NEPA Completion Notes | Open Energy Information  

Open Energy Info (EERE)

Completion Notes Completion Notes Jump to: navigation, search Property Name NEPA Completion Notes Property Type Text Pages using the property "NEPA Completion Notes" Showing 25 pages using this property. (previous 25) (next 25) B BLM-NV-WN-ES-08-01-1310, NV-020-08-01 + 8/2: Data reviewed for completion C CA-017-05-051 + 8/9 Data entry complete. Attached FONSI does not seem to be fully related to the attached EA. The FONSI is for a geothermal well and slimhole exploration project and the EA is for a pipeline project. Need to add Public Health and Safety as a resource 8/22/13 - The 'FONSI/DR is actually for EA CA-170-02-15 Bassalt Canyon..dated Jan 2002 KW 8/26/13 - I deleted the FONSI from this page. Filename is incorrect for the file and stands as "CA-017-05-51-EA-DR -FONSI.pdf," Andrew Gentile. Unable to find Final EA or FONSI online. When RMP added, add "Inyo National Forest "Land and Resource Management Plan" (LRMP) 1988"

326

Property:CompletionNotes | Open Energy Information  

Open Energy Info (EERE)

CompletionNotes CompletionNotes Jump to: navigation, search Property Name CompletionNotes Property Type Text Description List of data that still needs to be researched and entered for the NEPA document Subproperties This property has the following 2 subproperties: C CA-96062042 D DOI-BLM-CA-ES-2013-002+1793-EIS Pages using the property "CompletionNotes" Showing 25 pages using this property. (previous 25) (next 25) B BLM-NV-WN-ES-08-01-1310, NV-020-08-01 + 8/2: Data reviewed for completion C CA-017-05-051 + 8/9 Data entry complete. Attached FONSI does not seem to be fully related to the attached EA. The FONSI is for a geothermal well and slimhole exploration project and the EA is for a pipeline project. Need to add Public Health and Safety as a resource 8/22/13 - The 'FONSI/DR is actually for EA CA-170-02-15 Bassalt Canyon..dated Jan 2002 KW 8/26/13 - I deleted the FONSI from this page. Filename is incorrect for the file and stands as "CA-017-05-51-EA-DR -FONSI.pdf," Andrew Gentile. Unable to find Final EA or FONSI online. When RMP added, add "Inyo National Forest "Land and Resource Management Plan" (LRMP) 1988"

327

Nanosecond component in a femtosecond laser pulse  

Science Conference Proceedings (OSTI)

Experimental and computational results show that the coherent microwave scattering from a laser-induced plasma can be used for measuring the quality of a fs laser pulse. The temporal dynamics of the microwave scattered signal from the fs-laser induced plasma can be related to the effect of nanosecond tail of the fs laser pulse.

Shneider, M. N. [Mechanical and Aerospace Engineering, Princeton University, Princeton, New Jersey 08544 (United States); Semak, V. V. [ARL, Pennsylvania State University, University Park, Pennsylvania 16801 (United States); Zhang Zhili [Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville, Tennessee 37996 (United States)

2012-11-15T23:59:59.000Z

328

Plasmacytoid Dendritic Cells Are Crucial for the Initiation of Inflammation  

E-Print Network (OSTI)

downstream signaling pathways, in which the activation of the transcription factor nuclear factor kB (NF-kB) results in the production of proinflammatory cytokines, whereas the acti- vation of inhibitor of NF-kB (Ik

Gleeson, Joseph G.

329

Molecular Cell STAT3 Activation of miR-21 and miR-181b-1  

E-Print Network (OSTI)

cells via a positive feedback loop involving NF-kB, Lin28, let-7, and IL-6. We identify differentially, respectively, inhibit PTEN and CYLD tumor suppressors, leading to increased NF-kB activity required to maintain

Bulyk, Martha L.

330

Molecular Cell OTULIN Restricts Met1-Linked Ubiquitination  

E-Print Network (OSTI)

of IkBa, leading to nuclear translocation of nuclear factor kB (NF-kB) transcription factors. Together with transcription factors activated by MAP kinases, NF-kB promotes expression of genes that orchestrate

Komander, David

331

10.1101/gad.1936910Access the most recent version at doi: 2010 24: 1533-1545Genes Dev.  

E-Print Network (OSTI)

al. 2009). Studies with NF-kB (Leung et al. 2004) and glucocorticoid receptor (Meijsing et al. 2009- coid receptor and NF-kB affects the regulatory output of the bound complex, suggesting that small

332

Feiqiao Brian Yu 2012.03.16  

E-Print Network (OSTI)

individual cell (5). Another example deals with the study of NF-kB expression in mouse fibroblast cells (5). (B) Contrary to previous studies, NF-kB expression in mouse fibroblast cells occur digitally

Bejerano, Gill

333

Molecular mechanisms integrating genetic and calcium activity-dependent neurotransmitter specification  

E-Print Network (OSTI)

adhesion molecule vii NFAT NF-kB NFY Ngn1/2 NMDA NT p-cJuncontrast, activation of the NF-kB transcription factor by Ca

Kurtz, Lisa Miriam

2010-01-01T23:59:59.000Z

334

Worksheet  

U.S. Energy Information Administration (EIA) Indexed Site

of",6,5,"Aliant Energy Corp.","NF",1,,,30,30 8245,"Hastings City of",6,6,"Mid America Energy Co.","NF",14,,,561,561 8245,"Hastings City of",6,7,"Manitoba Hydro...

335

Worksheet  

U.S. Energy Information Administration (EIA) Indexed Site

Energy Trading","NF",270,,,15700,15700 9130,"Hutchinson Utilities Comm",6,6,"Manitoba Hydro Power","NF",299,,,4535,4535 9130,"Hutchinson Utilities Comm",6,7,"MidAmerica...

336

Optimization of Two-photon Excited Fluorescence Enhancement between Tunable and Broadband Femtosecond Laser Pulse Excitations  

E-Print Network (OSTI)

This project explores optimization of two-photon excited fluorescence (TPEF) enhancement between tunable narrowband and un-tuned broadband femtosecond (fs) laser pulse excitations for two-photon microscopy (TPM). The research is conducted preliminarily in time domain and comprehensively in frequency domain to understand the physics behind TPEF enhancement by un-tuned sub-10 fs nearly transform-limited pulse (TLP) versus tunable 140 fs pulse. The preliminary study on inverse proportionality of TPEF yield to fs-pulse duration delimits a general lower-bound to narrowband fs-pulse regime (pulse duration > 40 fs) with assumption of dye-molecule frequency invariant response. Deviations from this inverse proportionality in broadband fs-pulse regime (pulse duration < 40 fs) highlights dye-molecule frequency variant response, necessity of group delay dispersion (GDD) compensation, and broadband TLP for TPEF enhancement. The follow-up comparative study is made on un-tuned sub-10 fs TLP versus tunable 140 fs pulse excitations using three dye-phantoms (Indo-1, FITC, and TRITC) representative of fluorescent probes with similar TPEF characteristics. The integrated experimental system, with custom-designed GDD compensation, dispersion-less laser-beam expanding and focusing, and compound-lens for efficient fluorescence collection with good spectral resolution, ensures accurate TPEF measurements. Differentiated TPEF enhancements of Indo-1 (1.6), FITC (6.7), and TRITC (5.2) proportionally agree with calculated ones due to the overlap of fs-pulse second harmonic (SH) power spectrum with dye-molecule two-photon excitation (TPE) spectrum. Physically speaking, with broadband sub-10 fs TLP readily involved in both degenerate (v1 = v2) and non-degenerate (v1 ? v2) two-photon absorption (TPA), this un-tuned ultrashort fs-pulse excitation simultaneously allows for more accessibility to TPA-associated final states and diversely promotes population of thus excited dye-molecules with the three dye-phantoms. Under environmental influences (mutual quenching through one-photon absorption(s) and solvent effect), multicolor TPEF enhancement observed from a mixture of the three dyes shows promise of sub-10 fs TLP as simultaneous excitation for multiple-dye labeled samples in contrast to compromised excitation with narrowband fs-pulse tuning. Both single- and multicolor TPEF enhancements clarify tradeoff between tunability of narrowband fs-pulse and un-tuned broadband fs-pulse excitations, being instructive to further considerations on optimization of TPEF enhancement by strategic utilization of broadband fs-pulse for better performance of TPM.

Wang, Chao

2011-12-01T23:59:59.000Z

337

Dynamic Chromatin Localization of Sirt6 Shapes Stress-and Aging-Related Transcriptional Networks  

E-Print Network (OSTI)

control. Sirt6 can interact with the stress-responsive transcription factor NF-kB and regulate some NF-kB upon stress-signaling. The majority of genes bound by NF-kB subunit RelA recruit Sirt6, and dynamic of NF-kB signaling in stress response and aging. Citation: Kawahara TLA, Rapicavoli NA, Wu AR, Qu K

Quake, Stephen R.

338

A new indicator for breast cancer relapse identified http://www.eurekalert.org/pub_releases/2012-06/idm-ani061912.php[19/06/2012 16:38:11  

E-Print Network (OSTI)

the signalling of a protein complex called NF-kB, which is related to tumour progression. The activation of NF-kB, although the NF-kB complex is an essential requirement for it to remain active chronically-3-3 sigma and/or the activation of NF-kB in tumour cells as a factor in prognosis and diagnosis, as well

Foissac, Sylvain

339

A New Family of Synthetic Diterpenes that Regulates Cytokine Synthesis by Inhibiting IkBa  

E-Print Network (OSTI)

factors, col- lectively referred to as nuclear factor-kappa B (NF-kB).[4] In its resting state, NF-kB- flammatory stimuli induce phosphorylation of IkB leading to dissociation of NF-kB from its inhibitors. Once separated from IkB, NF-kB translocates into the nucleus, binds to the target DNA, and initiates gene

Theodorakis, Emmanuel

340

Molecular Cell Crystal Structures of the TRAF2: cIAP2  

E-Print Network (OSTI)

. They are crit- ical for canonical and noncanonical NF-kB signaling pathways. Here, we report the crystal-associated factors (TRAFs) in NF-kB and MAP kinase activation pathways in the signaling of multiple receptor families and the noncanon- ical NF-kB signaling pathways. In the noncanonical NF-kB signaling pathway, TRAF2 and cIAP1

Wu, Hao

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While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Molecular discrimination of structurally equivalent Lys63-linked and linear polyubiquitin chains  

E-Print Network (OSTI)

: ubiquitin linkage; deubiquitinase; ubiquitin binding domain; NF-kB signalling; TAK1/IKK/NEMO/NF-kB EMBO (inhibitor of kB kinase) pathway to nuclear factor-kappaB (NF-kB; Adhikari et al, 2007). TAK1 has been shown leads to the activation of IKK by TAK1 and subsequent NF-kB signalling (Adhikari et al, 2007

Komander, David

342

letters to nature 90 NATURE |VOL 406 |6 JULY 2000 |www.nature.com  

E-Print Network (OSTI)

that GSK-3b function is required for the NF-kB-mediated anti-apoptotic response to TNF-a. Our data also . Immunoblotting was carried out with I-kB-a (polyclonal, New England Biolabs), p65 NF-kB (polyclonal, Santa Cruz of either NF-kB-speci®c oligonu- cleotide probe containing two tandem NF-kB-binding sites (59

Davis, Trisha N.

343

To explore further the anti-inflammatory mech-anisms of PGRN and Atsttrin, we investigated  

E-Print Network (OSTI)

the role of PGRN and Atsttrin in the TNFa- induced activation of IKK (IkB kinase)­IkB­ NF-kB (nuclear). Treatment of BMDMs with rhPGRN or Atsttrin impaired TNFa-induced NF-kB nu- clear translocation, NF-kB binding to the IkBa promoter, and activation of gene expression by NF-kB (Fig. 6, C to F) (33). rh

344

DOI: 10.1126/science.1200840 , 484 (2011);332Science  

E-Print Network (OSTI)

activation of IKK (IkB kinase)­IkB­ NF-kB (nuclear factor kB) signaling. rhPGRN and Atsttrin blocked TNFa-induced NF-kB nu- clear translocation, NF-kB binding to the IkBa promoter, and activation of gene expression by NF-kB (Fig. 6, C to F) (33). rhPGRN and Atsttrin also inhibited the TNFa-induced phosphoryla- tion

Gleeson, Joseph G.

345

A novel derivative of decursin, CSL-32, blocks migration and production of inflammatory mediators and modulates PI3K  

E-Print Network (OSTI)

and modulates PI3K and NF-kB activities in HT1080 cells Seung-Hee Lee*, Jee Hyun Lee{ , Eun-Ju Kim*, WonB), phosphorylation of p65 subunit of NF-kB (nuclear factor-kB) and nuclear translocation of NF-kB, which are required. Keywords: cytokine; inflammation; invasion; NF-kB; signal transduction 1. Introduction Decursin

Lee, Won-Ha

346

A chicken c-Rel-estrogen receptor chimeric protein shows conditional nuclear localization, DNA binding, transformation and transcriptional  

E-Print Network (OSTI)

and dierentiation will potentially dier depend- ing on the level of expression. Keywords: c-Rel; NF-kB, Gerondakis et al., 1996). Structurally, c-Rel belongs to a larger family of transcription factors, the Rel/NF-kB family, which also includes RelA, RelB, NF-kB1, NF-kB2, Dorsal, Dif, and Relish. All members

?urovec, Michal

347

Joel L.Pomerantz1 , Elissa M.Denny and  

E-Print Network (OSTI)

@caltech.edu NF-kB is a critical target of signaling downstream of the T cell receptor (TCR) complex, but how TCR sig- naling activates NF-kB is poorly understood. We have developed an expression cloning strategy that can identify catalytic and noncatalytic molecules that par- ticipate in different pathways of NF-kB

Baltimore, David

348

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative  

E-Print Network (OSTI)

Regulation of Noncanonical NF-kB Signaling Irving C. Allen,1 Justin E. Wilson,1 Monika Schneider,2 John D of NLR proteins, including NLRP12, inhibits the transcription factor NF-kB, although physiologic and disease-rele- vant evidence is largely missing. Dysregulated NF-kB activity is associated with colonic

349

Tea Pigments Inhibit the Production of Type 1 (TH1) and Type 2 (TH2) Helper T Cell Cytokines  

E-Print Network (OSTI)

been linked to their capacity to inhibit the activation of nuclear factor-kB (NF-kB), a transcription. The current study examines the requirement for NF-kB in the immunosuppressive effects mediated by tea require NF-kB for gene expression, such as interleukin-2 (IL-2) and interferon gamma (IFN g

Brand, Paul H.

350

Transcriptomic Analysis of Host Immune and Cell Death Responses Associated with the Influenza A Virus PB1-F2  

E-Print Network (OSTI)

-apoptotic properties of PB1-F2. Using a NF-kB luciferase adenoviral vector, we were able to quantify in vivo the implication of NF-kB in the inflammation mediated by the influenza virus infection; we found that PB1-F2 expression intensifies the NF-kB activity. Finally, we quantified the neutrophil recruitment within

Paris-Sud XI, Université de

351

Integrative Genomic Approaches Identify IKBKE as a Breast Cancer Oncogene  

E-Print Network (OSTI)

. IKK3 acti- vates the nuclear factor-kappaB (NF-kB) path- way in both cell lines and breast cancers. These observations suggest a mechanism for NF-kB activation in breast cancer, implicate the NF-kB pathway

352

Melatonin Alters Age-Related Changes in Transcription Factors and Kinase Activation  

E-Print Network (OSTI)

not to alter the extent of NF-kB or AP-1 activation [14]. X-in the spleen, dietary a NF-kB activity (densitometic units)YC YM OC OM b NF-kB activity (densitometic units) Results

Bondy, Stephen Bondy C

2010-01-01T23:59:59.000Z

353

Molecular Cell, Volume 37 Supplemental Information  

E-Print Network (OSTI)

a gradual increase in NF-kB p65 nuclear concentration. (A) Wild-type HCT 116 cells were stimulated with increasing doses of TNF for 20 minutes. The nuclear translocation of NF-kB was assessed by immunofluorescence that increasing TNF doses induce uniformly increasing nuclear localization of NF-kB in the cell population. (C) We

Bulyk, Martha L.

354

sortium for sharing analysis results; C. Allen and H. McClure of the Yerkes Primate Center, Atlanta, and  

E-Print Network (OSTI)

when citing this paper. Achieving Stability of Lipopolysaccharide-Induced NF-kB Activation Markus W of the transcription factor NF-kB exhibit damped oscillatory behavior when cells are stimulated by tumor necrosis-like receptor 4 (TLR4) causes activation of NF-kB that requires two down- stream pathways, each of which when

Baltimore, David

355

Ah receptor represses acute-phase response gene expression without binding to its cognate response  

E-Print Network (OSTI)

Repression of the nuclear factor-kB (NF-kB) pathway has been extensively researched because of its pivotal NF-kB regulated-gene expression, especially acute-phase genes, such as serum amyloid A (Saa). Using of transcription factors, such as nuclear factor-kB (NF-kB), signal transducer and activator of transcription-3

Perdew, Gary

356

12. McDonald, J. C. & Whitesides, G. M. Poly(dimethylsiloxane) as a material for fabricating microfluidic devices. Accounts Chem. Res. 35, 491499 (2002).  

E-Print Network (OSTI)

macrophage NF-kB activation and contributes to the resolution of inflammation Toby Lawrence1 *, Magali Bebien and IKKb, and controls the activation of NF-kB transcription factors, which play a pivotal role in inflammation2 . Ample evidence indicates that IKKb mediates NF-kB activation in response to pro-inflamma- tory

Nizet, Victor

357

caspase-8 became enzymatically active after TCR stimulation (Fig. 3H and fig. S8G).  

E-Print Network (OSTI)

caspase-8 became enzymatically active after TCR stimulation (Fig. 3H and fig. S8G). Hence, NF-kB activation by antigen receptors requires enzyme activity of full-length caspase- 8. In the NF-kB-receptor signaling and as a selective signal transducer for NF-kB during the early genetic response to an antigen

Kharasch, Evan

358

Cell cycle and DNA damage response regulation by Spy1, and the intersection of FGFR and NFkappaB pathways  

E-Print Network (OSTI)

Bio-Rad). Quantification of NF-kB binding to the probe wasBio-Rad). The average NF-kB binding from three independentBio-Rad). Quantification of NF-kB binding to the probe was

McAndrew, Christopher William

2010-01-01T23:59:59.000Z

359

Acute liver injury upregulates microRNA-491-5p in mice, and its overexpression sensitizes Hep G2 cells for tumour necrosis factor-alpha-induced apoptosis.  

E-Print Network (OSTI)

expression of AFP, hsp-90 and NF-kB. Acknowledgements This90; miRNA, microRNA; NF-kB, nuclear factor-k B; siRNA, short90) and nuclear factor-kB (NF-kB). Overexpression of miRNA-

Wu, Jian; Zern, M A

2010-01-01T23:59:59.000Z

360

Control of Stochastic Gene Expression by Host Factors at the HIV Promoter  

E-Print Network (OSTI)

promoter contains cis- acting Sp1 and NF-kB elements that regulate gene expression via the recruitment lentivirus variants with mutations introduced in the Sp1 and NF-kB elements, we employed flow cytometry, m and reduction in the regulation of histone acetylation and deacetylation. Furthermore, the NF-kB sites exhibit

Schaffer, David V.

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

MEETING ABSTRACT Open Access Predominant role of Tax sumoylation in  

E-Print Network (OSTI)

MEETING ABSTRACT Open Access Predominant role of Tax sumoylation in Tax-induced NF-kB activation of the NF-kB pathway, a property that is required for HTLV-1-induced T cell immortalization. Tax activates the NF-kB pathway by acting both at cytoplasmic and nuclear levels. In the cytoplasm, Tax binds

Paris-Sud XI, Université de

362

Molecular Cell The Structure of the CYLD USP Domain  

E-Print Network (OSTI)

The tumor suppressor CYLD antagonizes NF-kB and JNK signaling by disassembly of Lys63-linked ubiqui- tin al., 2000). CYLD negatively regulates activation of the cell-survival effec- tor NF-kB, a finding for stimulation of NF-kB and JNK in the innate and adaptive immune response (Jin et al., 2007; Zhang et al., 2006

Komander, David

363

The intersection of NFkappaB and fibroblast growth factor receptor signaling pathways  

E-Print Network (OSTI)

Bio-Rad). Quantification of NF-kB binding to the probe wasBio- Rad). The average NF-kB binding from three independentBio-Rad). Quantification of NF-kB binding to the probe was

Drafahl, Kristine A.

2009-01-01T23:59:59.000Z

364

Blood proteolytic activity elevation and plasma protein degradation in spontaneously hypertensive rat models  

E-Print Network (OSTI)

G-protein alpha s, H-Ras, NF-kB, pard6, PI3K cat class IA,G-protein alpha-s, H-Ras, NF-kB, Pi3k cat class IA, PKA-cat,Beta-catenin, MDM2, MMP-2, NF-kb, PIAS2, SUMO- 1, XPA, p21

Chow, Jason C

2011-01-01T23:59:59.000Z

365

Molecular Cell Recruitment of the Linear Ubiquitin Chain Assembly  

E-Print Network (OSTI)

, and is required for efficient TNF-induced activation of NF-kB and JNK, resulting in apoptosis inhibition. Finally-activated protein (MAP) kinase cascades and NF-kB activation (Wajant et al., 2003). Ligand-induced trimerization., 2008). TRAF2 and RIP1 play important roles in the activation of JNK and NF-kB, respectively (Devin et

Komander, David

366

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing  

E-Print Network (OSTI)

-linked (also known as linear) Ub chains that regulate nuclear factor kB (NF-kB) signaling. Deubi by reducing kcat 240-fold. OTULIN overexpression or knockdown affects NF-kB re- sponses to LUBAC, TNFa has roles in NF-kB activation (Haas et al., 2009; Toku- naga and Iwai, 2012; Tokunaga et al., 2009

Komander, David

367

Metabolic disorders in heart diseases with an inflammatory background  

E-Print Network (OSTI)

2010 This editorial refers to `The p65 subunit of NF-kB binds to PGC-1a, linking inflammation. Introduction Cardiac hypertrophy and heart failure are associated with nuclear factor-kB (NF-kB) activation major pathways. 2. Link between NFkB and PGC-1a pathways The general term NF-kB traditionally refers

Paris-Sud XI, Université de

368

Gene Regulation in M Cell Lineages: In Vitro and In Vivo  

E-Print Network (OSTI)

LTbR agonist (Fig 2-1C). The NF-kB gene relB (Relb) has alsoof relB is regulated by NF-kB activation, and the LT?R andreceptors all signal through NF-kB activation, this finding

Wang, Jing

2011-01-01T23:59:59.000Z

369

Specific Recognition of Linear Ubiquitin Chains by NEMO  

E-Print Network (OSTI)

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-kB Activation Simin.03.007 SUMMARY Activation of nuclear factor-kB (NF-kB), a key medi- ator of inducible transcription in immunity, requires binding of NF-kB essential modulator (NEMO) to ubiquitinated substrates. Here, we report

Komander, David

370

Cancer Cell A Transcriptional Signature and Common  

E-Print Network (OSTI)

. As in atherosclerosis, oxidized LDL and its receptor OLR1 activate the inflammatory pathway through NF-kB, leading, 2006; De Marzo et al., 2007; Naugler and Karin, 2008; Pierce et al., 2009). Constitutively active NF-kB, and mouse models provide evidence for a causative role of NF-kB in malignant conversion and progression

Bulyk, Martha L.

371

Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune  

E-Print Network (OSTI)

. pneumophila lacking the Dot/Icm system is recognized by Toll-like receptors (TLRs), leading to a canonical NF-kB, thereby preventing synthesis of IkB, an inhibitor of the NF-kB transcription factor. Thus, macrophages infected with wildtype L. pneumophila exhibited prolonged activation of NF-kB, which was associated

Vance,. Russell

372

Cloning and characterization of Dorsal homologues in the hemipteran Rhodnius prolixusimb_909 681..690  

E-Print Network (OSTI)

by transcription factors of the Rel/ Nuclear Factor kappa B (Rel/NF-kB) family. We have cloned and characterized is that of Nuclear Factor kappa B (NF-kB), named after the transcrip- tional activator of the immunoglobulin kappa light chain in human B-lymphocytes (Sen & Baltimore, 1986). A func- tional NF-kB transcription factor

Lowenberger, Carl

373

Received 9 Nov 2012 | Accepted 28 Jan 2013 | Published 5 Mar 2013 Regulation of A20 and other OTU  

E-Print Network (OSTI)

such as activation of protein kinase cascades during NF-kB (nuclear factor-kB) activation2,3. Ub modifications described to regulate the transcription factor NF-kB (ref. 6), activation of which depends on an intricate in hyperinflammatory phenotypes consistent with deregulated NF-kB signalling. Mechanistically, A20 establishes

Komander, David

374

Molecular Cell Noncooperative Interactions between Transcription  

E-Print Network (OSTI)

the definition of anatomical boundaries during development. Here we show that NF-kB, a TF controlling noncoop- eratively. We observed that increasing concentra- tions of NF-kB are translated into gradual by combining quantitative measurements and a minimal physical model of an NF-kB-dependent promoter. We

Bulyk, Martha L.

375

Functional dissection of homeodomain transcription factors HoxA9 and Meis1 in myeloid leukemia : their epigenetic regulation and their downstream targets  

E-Print Network (OSTI)

protein 3. A20. Neg reg Toll/NF-kB signaling Socs3 Cytokine-2, C polypeptide. Adhesion, NF-kB activation Hsd11b1Peli1 Pellino1. Required for NF-kB activation through IL1R

Wang, Gang

2006-01-01T23:59:59.000Z

376

Second SICSA Workshop on Biological Networks: Theory and Applications  

E-Print Network (OSTI)

stimulation, oscillatory MAPK, p53, NF-kB network with optional UV modulation Oscillations have been factor kappa-light-chain-enhancer of activated B cell (NF-kB) is conducted. A candidate for a tumor necrosis factor- (TNF-) controlled stimulation, oscillating MAPK, p53, NF-kB network with optional

Edinburgh, University of

377

ARTICLE doi:10.1038/nature09853 Crystal structure of inhibitorof kB kinase b  

E-Print Network (OSTI)

a similar trimodular architecture and function. Nuclear factor kB (NF-kB) transcription factors are master regulators of inflammatory, immune and apoptotic responses1,2 . In the canonical pathway, NF-kB dimers. When cells are stimulated by NF-kB inducers, IkB proteins are phosphorylated by the Ser

Wu, Hao

378

Consolidated Financial Statements | Department of Energy  

NLE Websites -- All DOE Office Websites (Extended Search)

Reports » Consolidated Financial Statements Reports » Consolidated Financial Statements Consolidated Financial Statements December 20, 2013 Audit Report: OAS-FS-14-04 Federal Energy Regulatory Commission's Fiscal Year 2013 Financial Statement Audit December 12, 2013 Audit Report: OAS-FS-14-03 Department of Energy's Fiscal Year 2013 Consolidated Financial Statements December 11, 2013 Audit Report: OAS-FS-14-02 Department of Energy's Nuclear Waste Fund's Fiscal Year 2013 Financial Statement Audit November 25, 2013 Audit Report: OAS-FS-14-01 Federal Energy Regulatory Commission's Fiscal Year 2013 Financial Statement Audit August 12, 2013 Audit Report: OAS-FS-13-13 Southwestern Federal Power System's Fiscal Year 2012 Financial Statement Audit March 14, 2013 Audit Report: OAS-FS-13-12 Performance Audit of the Department of Energy's Improper Payment Reporting

379

Page not found | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

21 - 2530 of 26,777 results. 21 - 2530 of 26,777 results. Download Audit Report: OAS-FS-12-04 Information Technology Management Letter on the Audit of the Department of Energy's Consolidated Balance Sheet for Fiscal Year 2011 (OUO Not Available for Viewing) http://energy.gov/ig/downloads/audit-report-oas-fs-12-04 Download Audit Report: OAS-FS-11-04 Information Technology Management Letter on the Audit of the Department of Energy's Consolidated Balance Sheet for Fiscal Year 2010 (OUO Not Available for Viewing) http://energy.gov/ig/downloads/audit-report-oas-fs-11-04 Download Audit Report: OAS-FS-14-04 Federal Energy Regulatory Commission's Fiscal Year 2013 Financial Statement Audit http://energy.gov/ig/downloads/audit-report-oas-fs-14-04 Download Mirant Reply to Comments re Special Environmental Analysis,

380

Consolidated Financial Statements | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

November 15, 2011 November 15, 2011 Audit Report: OAS-FS-12-02 Department of Energy's Fiscal Year 2011 Consolidated Financial Statements November 2, 2011 Audit Report: OAS-FS-12-03 The Department of Energy's Nuclear Waste Fund's Fiscal Year 2011 Financial Statements June 14, 2011 Audit Report: OAS-FS-11-07 Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2010 April 7, 2011 Audit Report: OAS-FS-11-06 Department of Energy Isotope Program's Fiscal Year 2007 December 21, 2010 Audit Report: OAS-FS-11-04 Information Technology Management Letter on the Audit of the Department of Energy's Consolidated Balance Sheet for Fiscal Year 2010 (OUO Not Available for Viewing) December 20, 2010 Audit Report: OAS-FS-11-05 Management Letter on the Audit of the Department of Energy's Consolidated

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Glaser, UMC, Chem210 Notes FS97, 1997 --1 --C h e m i s t r y 2 1 0 --F a l l S e m e s t e r 1 9 9 7C h e m i s t r y 2 1 0 --F a l l S e m e s t e r 1 9 9 7  

E-Print Network (OSTI)

-- Preparation (a) Pyrolysis of Methane (Industrial only) 2 methane ---(1200oC, steam)---> HCCH + 3 H2 (b makes the acetylide anion and the acetylene is reformed by hydrolysis. R R C C R C H C- Na+ R C C Br Br

Glaser, Rainer

382

Table HC1-12a. Housing Unit Characteristics by West Census Region,  

U.S. Energy Information Administration (EIA) Indexed Site

2a. Housing Unit Characteristics by West Census Region, 2a. Housing Unit Characteristics by West Census Region, Million U.S. Households, 2001 Housing Unit Characteristics RSE Column Factor: Total U.S. West Census Region RSE Row Factors Total Census Division Mountain Pacific 0.5 1.0 1.7 1.1 Total .............................................................. 107.0 23.3 6.7 16.6 NE Census Region and Division Northeast ..................................................... 20.3 -- -- -- NF New England ............................................. 5.4 -- -- -- NF Middle Atlantic ........................................... 14.8 -- -- -- NF Midwest ....................................................... 24.5 -- -- -- NF East North Central ..................................... 17.1 -- -- -- NF West North Central ....................................

383

Self-Reported ADHD Symptoms and Performance on Working Memory Tests Ryan Beaston, Ashley Gilbert, Leslie Wagner, Lauren Littlefield  

E-Print Network (OSTI)

SPK J09CA0981 Turlock Bomb Loading Plant Groundwater Contamination HTRW SI CA SPK J09CA7054 Hanford LANDFILL HTRW RA-C OH LRL G05OH0018 PLUM BROOK ORD WORKS WWTP # 1 & 3 HTRW RI/FS OH LRL G05OH0018 PLUM BROOK ORD WORKS WWTP #2 HTRW RI/FS OH LRL G05OH0018 PLUM BROOK ORD WORKS GROUNDWATER HTRW RI/FS OH LRL G

Choate, Paul M.

384

Prfungsordnung fr den Masterstudiengang Umweltwissenschaften  

E-Print Network (OSTI)

) PL (ohne Note) RPT BC1 Organische Chemie II 1 300/10 K P 1. FS BC2 Bioorganische Chemie / Nukle Umweltwissenschaftler 2 150/5 R 2. FS Ph6 Besonderes Verwaltungsrecht 2 180/6 MP 2. FS Module aus Clustern der chemi: Organische Chemie II (BC1) - Kenntnisse zur Abschätzung der Reaktivität von organischen Verbin- dungen und

Greifswald, Ernst-Moritz-Arndt-Universität

385

We would like to thank you for joining Keystone Health Plan's (KHPE) East Point of Service program. Carrying a Keystone Point of Service ID card entitles you to access a large network of providers, our  

E-Print Network (OSTI)

/08) Flex Copay POS FI FLEXPOSFIPROGRAMV004 #12;3 Referred Benefits #12;#12;KHPE FS 624 HDBK HPBB#F68 Aug-13. ATTEST: Brian Lobley Senior Vice President Marketing & Consumer Business #12;#12;KHPE FS 624 HDBK HPBB........................................................................................................................3-123 #12;3-1 KHPE FS 624 HDBK HPBB#F68 Aug-13 INTRODUCTION Thank you for joining the Keystone

Boufadel, Michel

386

CELLFS: TAKING THE "DMA" OUT OF CELL PROGRAMMING  

Science Conference Proceedings (OSTI)

In this paper we present a new programming model for the Cell BE architecture of scalar multiprocessors. They call this programming model CellFS. CellFS aims at simplifying the task of managing I/O between the local store of the processing units and main memory. The CellFS support library provides the means for transferring data via simple file I/O operations between the PPU and the SPU.

IONKOV, LATCHESAR A. [Los Alamos National Laboratory; MIRTCHOVSKI, ANDREY A. [Los Alamos National Laboratory; NYRHINEN, AKI M. [Los Alamos National Laboratory

2007-01-09T23:59:59.000Z

387

A Generic Arc-Consistency Algorithm and its Specializations1  

E-Print Network (OSTI)

S = fS0 ::: Sng of Di and P = fP0 ::: Pmg of Dj are a piecewise decomposition of Di and Dj wrt C i there exists a piecewise decomposition S = fS0 ::: Sng and P = fP0 ::: Pmg of Di and Dj wrt Cij decompositions S = fS0 ::: Sng and P = fP0 ::: Png have the same number of groups and the groups can

Deville, Yves

388

Variant Handling, Inheritance and Composition in the ObjectMath Computer Algebra Environment  

E-Print Network (OSTI)

and Information Science Linköping University, S­581 83 Linköping, Sweden Email: {petfr,vaden contact from this body to Body2 *) rho; (* Density *) m := rho V; (* Mass *) (* External force from gravity *) F$[S1][Ext][1] := 0; F$[S1][Ext][2] := 0; F$[S1][Ext][3] := ­ g m; END Body1; Fig. 3

Zhao, Yuxiao

389

Local Power Functions of Tests for Double Unit Roots  

E-Print Network (OSTI)

fHH fbS f2H f2S fS fS fe feS fDD fD fSD f. fSb fHf fH fHf2. f2H f2S fD feS fb fD2 fS2 fDD fSb f.S f.f fH2 f ff f

Haldrup, Niels Prof.; Lildholdt, Peter

2000-01-01T23:59:59.000Z

390

Femtosecond Laser Frequency Combs  

Science Conference Proceedings (OSTI)

... to all of these is the continued development of the lasers themselves. We are exploring and comparing different types of fs-laser comb technology ...

391

Page not found | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

ciodownloadscomputer-system-retirement-guidelines Download Audit Report: OAS-FS-13-01 Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2011 Financial...

392

NIST Manuscript Publication Search  

Science Conference Proceedings (OSTI)

... train from a mode-locked semiconductor laser (MLLD) to an external clock signal and achieved the lowest timing jitter (20 fs, intergrated from 1 Hz ...

2012-04-09T23:59:59.000Z

393

Audit of Departmental Integrated Standardized Core Accounting...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Audit of Departmental Integrated Standardized Core Accounting System (DISCAS) Operations at Selected Field Sites, AP-FS-97-02 Audit of Departmental Integrated Standardized Core...

394

Process Evaluations | Superconducting Magnet Division  

NLE Websites -- All DOE Office Websites (Extended Search)

Process Evaluations Process Assessment Form Operational Control Form Environmental Mgmt. Program Training Module Process Description AM-522-EAO (pdf) OCF (pdf) EMP (pdf) AM-ENV-FS1...

395

1The Citizen Volume 6 Issue 1 Spring 2012  

E-Print Network (OSTI)

in Chernobyl. Science 314: 62-3, 2006. Caulfield T, Cook-Deegan R, Kieff FS, Walsh JP: Evidence and Anecdotes

Scott, Robert A.

396

Materials and Molecular Research Division annual report, 1977  

DOE Green Energy (OSTI)

Progress in research in structure of materials, mechanical, and physical properties, solid state physics, and materials chemistry, including chemical structure, high temperature and surface chemistry, is reported. (FS)

Not Available

1977-01-01T23:59:59.000Z

397

Page not found | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

udit-report-oas-fs-11-03 Download Categorizing Threat Building and Using a Generic Threat Matrix http:energy.govoedownloadscategorizing-threat-building-and-using-generic-threa...

398

Symbolic reachable set computation of piecewise affine hybrid automata and its application to  

E-Print Network (OSTI)

] = 1 if (vi vj) 2 E and a unique symbol i j otherwise. The set of strings S consist of fs1, s2, ..., sNg

Breitling, Rainer

399

ACOUSTIC SOURCE SEPARATION: FUNDAMENTAL ISSUES Seungjin CHOI  

E-Print Network (OSTI)

the con dence of our approximation. Lemma 2.1. Let > 0 be given, and let S = fs1;s2;:::;sng be a set

Choi, Seungjin

400

Genome Biology 2004, 5:R95 commentreviewsreportsdepositedresearchrefereedresearchinteractionsinformation  

E-Print Network (OSTI)

- networks, Net, is defined in terms of these: Enz ¼ fE1; . . . ; ELg; Sub ¼ fS1; . . . ; SNg; Int ¼ fY1

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

MULTICHANNEL SIGNAL SEPARATION FOR COCKTAIL PARTY SPEECH RECOGNITION: A DYNAMIC RECURRENT NETWORK  

E-Print Network (OSTI)

and some nonsingular di­ agonal matrix \\Lambda. Theorem 1 (Skitovich­Darmois) Let fs1 ; s2 ; : : : ; sng

Choi, Seungjin

402

MSTC - Microsystems Science, Technology, and Components - Failure...  

NLE Websites -- All DOE Office Websites (Extended Search)

circuit edit TEM SQUID Deprocessing laboratory Optical Beam Floating Substrate Passive Voltage Contrast (FS-PVC) E-beam based technique Scanning electron beam charges metal...

403

Final Supplemental Environmental Impact Statement for a Geologic...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

- Nevada Rail Transportation Corridor DOEEIS-0250F-S2 and Final Env Final Supplemental Environmental Impact Statement for a Geologic Repository for the Disposal of Spent Nuclear...

404

Mitsuru Uesaka Nuclear Engineering Research Laboratory ,  

NLE Websites -- All DOE Office Websites (Extended Search)

plasma cathode by 12 TW, 50 fs laser and its application to radiation chemistry Mitsuru Uesaka Nuclear Engineering Research Laboratory , University of Tokyo June 26, 2004...

405

Page not found | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Waste Fund's Fiscal Year 2011 Financial Statements http:energy.govigdownloadsaudit-report-oas-fs-12-03 Rebate Coal Mining Regulations (Kentucky) Kentucky Administrative...

406

Cover  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2011 Financial Statement Audit OAS-FS-13-01 October 2012 UNITED STATES DEPARTMENT OF ENERGY OFFICE OF...

407

Uranium Enrichment Decontamination and Decommissioning Fund's...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Uranium Enrichment Decontamination and Decommissioning Fund's Fiscal Year 2008 and 2007 Financial Statement Audit, OAS-FS-10-05 Uranium Enrichment Decontamination and...

408

Follow-up to NIST's Consideration of XTS-AES as ...  

Science Conference Proceedings (OSTI)

... of encryption products including the Brocade Encryption Switch - a 32 port switch, and the FS8-18 blade for the ... Computer manufacturers relay the ...

2012-12-05T23:59:59.000Z

409

Design Studies for a VUV--Soft X-ray Free-Electron Laser Array  

E-Print Network (OSTI)

bunch arrival time in the LCLS, and another system that willFERMI@Elettra and 100 fs for LCLS, both requiring about 200-

Corlett, J.

2010-01-01T23:59:59.000Z

410

Agreement for Minority Financial Institutions Participation in...  

NLE Websites -- All DOE Office Websites (Extended Search)

& Publications Agreement for Minority Financial Institutions Participation in the Bank Deposit Financial Assistance Program Audit Report: OAS-FS-13-13 Financial Management Handbook...

411

U.S. Virgin Islands - U.S. Energy Information Administration (EIA ...  

U.S. Energy Information Administration (EIA)

U.S. Geological Survey, Assessment of Undiscovered Oil and Gas Resources of the Black Warrior Basin Province, 2002, USGS Fact Sheet FS-038-03, April 2003

412

Patterns and Etiologies of Diarrheal Illness Among Two Key Immunocompromised Populations: HIV-Infected and Elderly  

E-Print Network (OSTI)

factsheets/fs330/en/print.html. Kosek M, Bern C, GuerrantMicrobiology. 1996;30:113-123. Kosek M, Bern C, Guerrant RL.

Saha, Sona Rhiju

2010-01-01T23:59:59.000Z

413

Microsoft PowerPoint - 040626(muroya).ppt [Read-Only  

NLE Websites -- All DOE Office Websites (Extended Search)

of Tokyo, JAPAN Design and construction of ultrafast pulse radiolysis system using laser photocathode rf-gun combined with fs laser Development of new pulse radiolysis system...

414

Microsoft Word - Ultrafast symposium agenda7.doc  

NLE Websites -- All DOE Office Websites (Extended Search)

Wishart, BNL 8:55 Design and construction of ultrafast pulse radiolysis system using laser photocathode rf-gun combined with fs laser, University of Tokyo, Yusa Muroya,...

415

AHI1 gene mutations cause specific forms of Joubert syndrome-related disorders  

E-Print Network (OSTI)

10yr n.a. Q423X fs509X 6mo CSP Exons: Protein mutations: Ageabn-abnormalities; CSP-cavum septum pellucidum; CVH-

2006-01-01T23:59:59.000Z

416

Page not found | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

and stay safe. http:energy.govarticlesannouncing-apps-vehicles-challenge Download Audit Report: OAS-FS-13-09 Department of Energy's Isotope Development and Production for...

417

Page not found | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

and Production for Research and Applications Program's Fiscal Year 2010 Balance Sheet Audit http:energy.govigdownloadsaudit-report-oas-fs-13-11 Article T-549: Adobe...

418

Decay constants of B and D mesons from improved relativistic lattice QCD with two flavours of sea quarks  

E-Print Network (OSTI)

We present a calculation of the B and D meson decay constants in lattice QCD with two (Nf=2) flavours of light dynamical quarks, using an O(a)-improved Wilson action for both light and heavy quarks and a renormalization-group improved gauge action. Simulations are made at three values of lattice spacing a=0.22, 0.16, 0.11 fm and four values of sea quark mass in the range m_PS/m_V \\~= 0.8-0.6. Our estimate for the continuum values of the decay constants are fBd = 208(10)(11) MeV, fBs = 250(10)(13)(^{+8}_{-0}) MeV, fDd = 225(14)(14) MeV, fDs = 267(13)(17)(^{+10}_{-0}) MeV for Nf=2 where the statistical and systematic errors are separately listed, and the third error for fBs and fDs show uncertainty of determination of strange quark mass. We also carry out a set of quenched simulations using the same action to make a direct examination of sea quark effects. Taking the ratio of results for Nf=2 and Nf=0, we obtain fb^{Nf=2}/fb^{Nf=0} = 1.11(6), fbs^{Nf=2}/fbs^{Nf=0} = 1.14(5), fd^{Nf=2}/\\fd^{Nf=0} = 1.03(6), fds^...

Khan, A A; Burkhalter, R; Ejiri, S; Fukugita, M; Hashimoto, S; Ishizuka, N; Iwasaki, Y; Kanaya, K; Kaneko, T; Kuramashi, Y; Manke, T; Nagai, K; Okawa, M; Shanahan, H P; Ukawa, A; Yoshi, T

2001-01-01T23:59:59.000Z

419

Explicit control a batch-aware distributed file system  

Science Conference Proceedings (OSTI)

We present the design, implementation, and evaluation of the Batch-Aware Distributed File System (BAD-FS), a system designed to orchestrate large, I/O-intensive batch workloads on remote computing clusters distributed across the wide area. BAD-FS consists ...

John Bent; Douglas Thain; Andrea C. Arpaci-Dusseau; Remzi H. Arpaci-Dusseau; Miron Livny

2004-03-01T23:59:59.000Z

420

6. Chan, F. K., Siegel, M. R. & Lenardo, J. M. Signaling by the TNF receptor superfamily and T cell homeostasis. Immunity 13, 419422 (2000).  

E-Print Network (OSTI)

, T., Green, D. R. & Verma, I. M. Suppression of TNF-a-induced apoptosis by NF-kB. Science 274, 787 functions: JNK activation is not linked to apoptosis while NF-kB activation prevents cell death. Cell 87., Dixit, V. M. & Goeddel, D. V. TRAF2-mediated activation of NF-kB by TNF receptor 2 and CD40. Science 269

Hutchinson, John

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

of May 16, 2013. This information is current as  

E-Print Network (OSTI)

-binding proteins TGF-b­activated kinase 1 (TAK1)­binding protein (TAB)2 and TAB3 are implicated in NF-kB signaling via TAK1 activation. However, TAB2 alone is dispensable for NF-kB activation in embryonic fibroblasts, but not NF-kB, in response to TLR and CD40 stimulation in B cells. Surprisingly, TAB2 and TAB3

422

RELB, A NEW PARTNER OF ARYL HYDROCARBON RECEPTOR-MEDIATED TRANSCRIPTION  

E-Print Network (OSTI)

-00268250,version1-31Mar2008 #12;3 INTRODUCTION The NF-kB/Rel transcription factors play critical roles, and apoptosis. Transcriptionally active NF-kB dimers are formed by combinatorial association of five subunits: p50, RelA (p65), p52, c-Rel, and RelB (1). The classic inducible NF-kB heterodimer consists of the p50

Paris-Sud XI, Université de

423

A jB sequence code for pathway-specific innate immune responses  

E-Print Network (OSTI)

of the NF-kB family of transcription factors, for example, vertebrate p50 and p65 (Ghosh et al, 1998; Karin and Ben-Neriah, 2000; Brennan and Anderson, 2004; Xiao and Ghosh, 2005). In the absence of a stimulus, NF-kB that allow NF-kB factors to enter the nucleus and direct expression of antimicrobial agents and secondary

424

(161), ra11. [DOI: 10.1126/scisignal.2001501]4Science Signaling Benedict, Gourisankar Ghosh and Alexander Hoffmann (22 February 2011)  

E-Print Network (OSTI)

of Interferon Response Elements by NF-kB p50 Christine S. Cheng,1,2,3 Kristyn E. Feldman,1,2 James Lee,1 programs. Members of the nuclear factor kB (NF-kB) and interferon (IFN) regulatory factor (IRF-down and bottom-up systems biology approaches, we have identified the NF-kB p50 homodimer as a regulator of IRF

Hasty, Jeff

425

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3  

E-Print Network (OSTI)

function and NF-kB signaling Di Sha, Lih-Shen Chin? and Lian Li? Department of Pharmacology and CenterB kinase/nuclear factor kB (NF-kB) pathway. Furthermore, the ability of PINK1 to promote parkin-mediated ubiquitin signaling and implicate the deregulation of the PINK1/parkin/NF-kB neuroprotective signaling

Li, Lian

426

www.cell-research.com | Cell Research Guoliang Qing et al.  

E-Print Network (OSTI)

B, inhibitor of NF-kB; IKK, IkB kinase Received 28 September 2006; revised 9 October 2006; accepted 10 October that the IkB kinase (IKK), an essential activator of NF-kB, is selectively degraded by autophagy when Hsp90 and establish a molecular link among Hsp90, NF-kB and autophagy Cell Research (2006) 16:895-901. doi:10.1038/sj

Cai, Long

427

letters to nature NATURE |VOL 414 |13 DECEMBER 2001 |www.nature.com 759  

E-Print Network (OSTI)

±1318 (1999). 2. Khush, R. S., Leulier, F. & Lemaitre, B. Drosophila immunity: two paths to NF-kB. Trends. Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kB receptor-mediated Drosophila immune response requires Dif, an NF-kB factor. Genes Dev. 13, 792±797 (1999

Schnaufer, Achim

428

Molecular Cell Hydrogen Sulfide-Linked Sulfhydration  

E-Print Network (OSTI)

Molecular Cell Article Hydrogen Sulfide-Linked Sulfhydration of NF-kB Mediates Its Antiapoptotic@jhmi.edu DOI 10.1016/j.molcel.2011.10.021 SUMMARY Nuclear factor kB (NF-kB) is an antiapoptotic tran- scription factor. We show that the antiapoptotic actions of NF-kB are mediated by hydrogen sulfide (H2S

Dong, Xinzhong

429

POSTER PRESENTATION Open Access HIV triggers immunoregulatory dendritic cells  

E-Print Network (OSTI)

T cells through the non-canonical NF-kB pathway O Manches1* , MV Fernandez1 , J Plumas2 , L Chaperot2 , N activation of the non-canonical NF-kB pathway in pDC, and is essential for IDO induction. TLR7 triggering-dependent fashion, allowing cDC to induce Treg from naïve CD4+ T cells. Conclusion The non-canonical NF-kB pathway

Paris-Sud XI, Université de

430

Epigenetic Upregulation of lncRNAs at 13q14.3 in Leukemia Is Linked to the In Cis Downregulation of a  

E-Print Network (OSTI)

of a Gene Cluster That Targets NF-kB Angela Garding1,2. , Nupur Bhattacharya1.¤a , Rainer Claus3¤b , Melanie NF-kB activity, which we could show after overexpression, siRNA­mediated knockdown, and dominant/16 family of genes at 13q14.3 as the strongest inducers of NF-kB activity. In summary, the tumor suppressor

Rippe, Karsten

431

Molecular Cell Structural Basis for Recognition  

E-Print Network (OSTI)

.01.012 SUMMARY NEMO is the regulatory subunit of the IkB kinase (IKK) in NF-kB activation, and its CC2-LZ region. INTRODUCTION NF-kB proteins are evolutionarily conserved master regulators of immune and inflammatory responses/Thr-specific IkB kinase (IKK) signalosome is at the bottleneck for NF-kB activation because activated IKK

Wu, Hao

432

(290), ra75. [DOI: 10.1126/scisignal.2004097]6Science Signaling Linda C. Hsieh-Wilson and David Baltimore (27 August 2013)  

E-Print Network (OSTI)

Function of the NF-kB Protein c-Rel by O-GlcNAc Glycosylation Parameswaran Ramakrishnan,1 * Peter M. Clark factor nuclear factor kB (NF-kB) rapidly reprograms gene expression in response to various stimuli stress. We report that the NF-kB subunit c-Rel is modified and acti- vated by O-GlcNAcylation. We

Gleeson, Joseph G.

433

Lattice Study of the Conformal Window in QCD-like Theories  

E-Print Network (OSTI)

Using lattice simulations, we study the extent of the conformal window for an $\\text{SU}(3)$ gauge theory with $N_f$ Dirac fermions in the fundamental representation. We present evidence that the infrared behavior is conformal for $12 \\leq N_f \\leq 16$, governed by an infrared fixed point, while confinement and chiral symmetry breaking are present for $N_f \\leq 8$.

Thomas Appelquist; George T. Fleming; Ethan T. Neil

2007-12-04T23:59:59.000Z

434

Table HC1-11a. Housing Unit Characteristics by South Census Region,  

U.S. Energy Information Administration (EIA) Indexed Site

1a. Housing Unit Characteristics by South Census Region, 1a. Housing Unit Characteristics by South Census Region, Million U.S. Households, 2001 Housing Unit Characteristics RSE Column Factor: Total U.S. South Census Region RSE Row Factors Total Census Division South Atlantic East South Central West South Central 0.5 0.9 1.2 1.4 1.4 Total .............................................................. 107.0 38.9 20.3 6.8 11.8 NE Census Region and Division Northeast ..................................................... 20.3 -- -- -- -- NF New England ............................................. 5.4 -- -- -- -- NF Middle Atlantic ........................................... 14.8 -- -- -- -- NF Midwest ....................................................... 24.5 -- -- -- -- NF East North Central .....................................

435

Single-qubit-gate error below 10 in a trapped ion  

Science Conference Proceedings (OSTI)

... computers depends on the ability to accurately control sensitive super- position amplitudes by ... near 1.25 GHz, coupled with a 4-nF capacitor to one ...

2011-10-28T23:59:59.000Z

436

THE LONG TERM CALIBRATION STABILITY OF CRITICAL ...  

Science Conference Proceedings (OSTI)

... through nf flow tubes with circular cross section, ... Real Gas Eflects in Critical Flow through Nozzles ... of the Effects of Heat Transfer and Compressible ...

2012-10-29T23:59:59.000Z

437

Mosaic neurofibromatosis type 1  

E-Print Network (OSTI)

with neurofibromatosis type 1 (NF1) with microdeletionsM, Huson S. Mosaic (segmental) neurofibromatosis type 1and type 2: no longer neurofibromatosis type 5. Am J Med

Liang, Christine; Schaffer, Julie V

2008-01-01T23:59:59.000Z

438

Construction of Risk-Averse Enhanced Index Funds  

E-Print Network (OSTI)

?George Washington University, Washington, DC, 20052, mlejeune@gwu.edu. The author is partially supported by the Grant #. W911NF-09-1-0497 from the...

439

NVN-079666 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2541.85 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

440

NVN-079352 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1160 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

NVN-079665 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2560 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

442

NVN-079668 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2585.51 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

443

NVN-079664 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

444

NVN-074253 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

445

NVN-079307 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

446

NVN-079663 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2213.1 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

447

NVN-079310 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 655 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

448

NVN-074250 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1199 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

449

NVN-074254 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 2280 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

450

Table 2. Fuel Oil Consumption and Expenditures in U.S. Households ...  

U.S. Energy Information Administration (EIA)

1 A small amount of fuel oil used for appliances is included in "Fuel Oil" under "All Uses." NF = No applicable RSE row factor.

451

BMC Cancer BioMed Central  

E-Print Network (OSTI)

Research article Genistein inhibits radiation-induced activation of NF-?B in prostate cancer cells promoting apoptosis and G2 /M cell cycle arrest

Julian J Raffoul; Yu Wang; Omer Kucuk; Jeffrey D Forman; Fazlul H Sarkar; Gilda G Hillman; Jeffrey D Forman; Fazlul H Sarkar; Gilda G Hillman

2006-01-01T23:59:59.000Z

452

Stuart R Hudson | Princeton Plasma Physics Lab  

NLE Websites -- All DOE Office Websites (Extended Search)

approach for optimizing currents in H-1NF stellarator in operation in the Plasma Research Laboratory at the ANU to control vacuum magnetic islands was introduced. After...

453

Slide 1  

National Nuclear Security Administration (NNSA)

chemistry (AC) and materials characterization (MC) mission work CMR Chemistry and Metallurgy Research CMRR-NF CMR Replacement - Nuclear Facility RLUOB Radiological...

454

Chemistry and Metallurgy Research Replacement - Nuclear Facility...  

National Nuclear Security Administration (NNSA)

Chemistry and Metallurgy Research Replacement - Nuclear Facility (CMRR-NF SEIS) | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing...

455

CACA-014408 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 693.6 Bid PriceAcre Managing Field Office none provided Surface Manager INYO NF Lessee 1...

456

NVN-077646 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 80 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

457

NVN-079667 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1920 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

458

NVN-077647 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 640 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

459

NVN-079276 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 640 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

460

NVN-078687 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLEASENONCOMPETITI Total Acreage 1180 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 REESE...

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

NVN-079291 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLSENONCOMPPRE2005 Total Acreage 1295.88 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 GRADIENT...

462

NVN-077668 | Open Energy Information  

Open Energy Info (EERE)

Case Status Authorized Case Type GEOLEASENONCOMPETITI Total Acreage 3297.94 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 NGP BLUE...

463

CACA-011667 | Open Energy Information  

Open Energy Info (EERE)

Acres) Case Status Authorized Case Type GEOLSECOMPPRE2005 Total Acreage 1590 Bid PriceAcre Managing Field Office none provided Surface Manager INYO NF Lessee 1...

464

NVN-080159 | Open Energy Information  

Open Energy Info (EERE)

(section) Case Status Authorized Case Type GEOLEASENONCOMPETITI Total Acreage 640 Bid PriceAcre Managing Field Office none provided Surface Manager TOIYABE NF Lessee 1 NGP BLUE...

465

Die Jontophorese der mit medikamentö  

Science Conference Proceedings (OSTI)

Flora, 131. N.F. 31, 87--112, 1936. Die bevorzugte Aufnahme saurer Farbstoffe bei hoher Wasserstoffionen- konzentration der die Zellen yon Asperffillus niger...

466

Dynamic Modeling of Behavior Change H. T. Banks, Keri L. Rehm, Karyn L. Sutton  

E-Print Network (OSTI)

chacun des noeuds des deux documents : sds1(r) = snf 1(r) = pr tree ? p nf 1 tree + pr paper ? pnf 1

467

Control of size and charge selectivity in amphiphilic graft copolymer nanofiltration membranes  

E-Print Network (OSTI)

The throughput and efficiency of membrane separations make polymer filtration membranes an important resource for the pharmaceutical, food and wastewater treatment industries. Nanofiltration (NF) membranes fill an important ...

Lovell, Nathan Gary

2010-01-01T23:59:59.000Z

468

Numerical Investigation of Interaction Between Hydraulic Fractures and Natural Fractures  

E-Print Network (OSTI)

Hydraulic fracturing of a naturally-fractured reservoir is a challenge for industry, as fractures can have complex growth patterns when propagating in systems of natural fractures in the reservoir. Fracture propagation near a natural fracture (NF) considering interaction between a hydraulic fracture (HF) and a pre-existing NF, has been investigated comprehensively using a two dimensional Displacement Discontinuity Method (DDM) Model in this thesis. The rock is first considered as an elastic impermeable medium (with no leakoff), and then the effects of pore pressure change as a result of leakoff of fracturing fluid are considered. A uniform pressure fluid model and a Newtonian fluid flow model are used to calculate the fluid flow, fluid pressure and width distribution along the fracture. Joint elements are implemented to describe different NF contact modes (stick, slip, and open mode). The structural criterion is used for predicting the direction and mode of fracture propagation. The numerical model was used to first examine the mechanical response of the NF to predict potential reactivation of the NF and the resultant probable location for fracture re-initiation. Results demonstrate that: 1) Before the HF reaches a NF, the possibility of fracture re-initiation across the NF and with an offset is enhanced when the NF has weaker interfaces; 2) During the stage of fluid infiltration along the NF, a maximum tensile stress peak can be generated at the end of the opening zone along the NF ahead of the fluid front; 3) Poroelastic effects, arising from fluid diffusion into the rock deformation can induce closure and compressive stress at the center of the NF ahead of the HF tip before HF arrival. Upon coalescence when fluid flows along the NF, the poroelastic effects tend to reduce the value of the HF aperture and this decreases the tension peak and the possibility of fracture re-initiation with time. Next, HF trajectories near a NF were examined prior to coalesce with the NF using different joint, rock and fluid properties. Our analysis shows that: 1) Hydraulic fracture trajectories near a NF may bend and deviate from the direction of the maximum horizontal stress when using a joint model that includes initial joint deformation; 2) Hydraulic fractures propagating with higher injection rate or fracturing fluid of higher viscosity propagate longer distance when turning to the direction of maximum horizontal stress; 3) Fracture trajectories are less dependent on injection rate or fluid viscosity when using a joint model that includes initial joint deformation; whereas, they are more dominated by injection rate and fluid viscosity when using a joint model that excludes initial joint deformation.

Xue, Wenxu

2010-12-01T23:59:59.000Z

469

Observation of femtosecond laser-induced nanostructure-covered large scale waves on metals  

SciTech Connect

Following femtosecond (fs) laser pulse irradiation, we produce a type of periodic surface structure with a period tens of times greater than the laser wavelength and densely covered by an iterating pattern that consists of stripes of nanostructures and microscale cellular structures. The morphology of this large scale wave pattern crucially depends on laser fluence and the number of laser pulses, but not on the laser wavelength. Our study suggests that this large scale wave is initiated by fs laser induced surface unevenness followed by periodically distributed nonuniform surface heating from fs pulse irradiation.

Hwang, Taek Yong; Guo Chunlei [Institute of Optics, University of Rochester, Rochester, New York 14627 (United States)

2011-04-15T23:59:59.000Z

470

ROCKY MOUNTAIN JOURNAL OF MATHEMATICS  

E-Print Network (OSTI)

factors of i = 1,...,t, j = 1,...,n-1, by n, we have nfAjm+i = (jmnf +nif -nf +n).-.(jmnf +nif) = (.(if - f +1) -j)...(nif - j) (modp), so that Multiplying both sides of this congruence by Bn = n(2n) .(tf n

Williams, Kenneth Stuart

471

LINE","COMPNAME","COMPID","YEAR","PURCNAME","SALETYPE","MEGAWATT...  

U.S. Energy Information Administration (EIA) Indexed Site

Spencer City of",554,1999,"Iowa State University","NF",3543,0,0,87758,87758 2,"Spencer City of",554,1999,"Alliant","NF",28,0,0,1443,1443 3,"Spencer City of",554,1999,"Mid-America...

472

Cytokine-Induced Signaling Networks Prioritize Dynamic Range  

E-Print Network (OSTI)

. For example, the transcription factor nuclear factor-kB (NF-kB) is widely regarded as a prosurvival protein-IAP2, Bcl-xL, and c-FLIP (Karin and Lin, 2002). In response to DNA-damaging agents, however, nuclear NF-kB

473

Noise-Limited Frequency Signal Transmission in Gene Circuits Cheemeng Tan,* Faisal Reza,*y  

E-Print Network (OSTI)

clocks (2), Ca21 signaling pathways (3,4), p53 DNA repair pathways (5), NF-kB pathways (6), and cell of ;0.008/s significantly increased the activity of Ras proteins (22). Similarly, the frequency of NF-kB

You, Lingchong

474

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer  

E-Print Network (OSTI)

(Watanabe et al., 2008). NOD2 stimulation leads to the activation of MAP kinase and NF-kB signaling pathways). Together, these studies suggest that innate immune signaling triggered by the commensal bacteria-TLR or NOD-NF-kB

475

Molecular Cell Short Article  

E-Print Network (OSTI)

of an HBO1 complex, ING4 has also been reported to repress transcription of the NF-kB and hypoxia response to directly interact with the RelA subunit of NF-kB and with Egln1/HPH2 (hypoxia inducible factor Prolyl

Gozani, Or

476

Molecular Cell Control of Proinflammatory Gene  

E-Print Network (OSTI)

-depen- dent erasure of H4K20me3 is required for effective gene activation and is achieved by NF-kB-depen- dent such as nuclear factor-k B (NF-kB), activator protein 1 (AP1), and interferon regulatory factor (IRFs

Higgins, Darren

477

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis  

E-Print Network (OSTI)

of signal 1 (NF-kB), the NLRP3 inflammasome was activated by mitochon- drial apoptotic signaling activation (Latz, 2010). The first signal (signal 1), often NF-kB activation, induces pro-IL-1b and NLRP3

478

Identification of genetic variation and putative regulatory regions in bovine CARD15  

E-Print Network (OSTI)

have an enhanced ability to activate nuclear factor kappa-B (NF-kB) (Miceli-Richard et al. 2001), while components resulting in a perturbation of NF-kB activation (Girardin et al. 2003; Gutierrez et al. 2002

Taylor, Jerry

479

Tumor and Stem Cell Biology Akt2 Regulates All Akt Isoforms and Promotes Resistance to  

E-Print Network (OSTI)

of NF-kB, cAMP responsive element­binding protein (CREB), and CBP/p300 to the miR-21 promoter (6). The LKB1/AMPK pathway on the other hand, inhibits mTOR and activates NF-kB and Notch1

480

NIKKI GEORGINA TRAYLOR-KNOWLES ntk1717@gmail.com (410) 905-5107  

E-Print Network (OSTI)

., Goucher, H., Finnerty, J.R., Gilmore, T.D. (2010) Characterization of the core elements of the NF-kB., Gilmore, T.D., and Finnerty, J.R. (2009) Two alleles encoding transcription factor NF-kB in the sea

Palumbi, Stephen

Note: This page contains sample records for the topic "nf lrmp fs" from the National Library of EnergyBeta (NLEBeta).
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481

Worksheet  

U.S. Energy Information Administration (EIA) Indexed Site

ty",6,3,"AVISTA","NF",573733,,,22608999,22608999 3413,"PUD No 1 of Chelan County",6,4,"BC HYDRO","NF",5,,,211,211 3413,"PUD No 1 of Chelan County",6,5,"BENTON COUNTY...

482

Table HC1-9a. Housing Unit Characteristics by Northeast Census Region,  

U.S. Energy Information Administration (EIA) Indexed Site

9a. Housing Unit Characteristics by Northeast Census Region, 9a. Housing Unit Characteristics by Northeast Census Region, Million U.S. Households, 2001 Housing Unit Characteristics RSE Column Factor: Total U.S. Northeast Census Region RSE Row Factors Total Census Division Middle Atlantic New England 0.5 1.0 1.2 1.6 Total .............................................................. 107.0 20.3 14.8 5.4 NE Census Region and Division Northeast ..................................................... 20.3 20.3 14.8 5.4 NF New England ............................................. 5.4 5.4 Q 5.4 NF Middle Atlantic ........................................... 14.8 14.8 14.8 Q NF Midwest ....................................................... 24.5 -- -- -- NF East North Central ..................................... 17.1 -- -- -- NF

483

Property:SurfaceManager | Open Energy Information  

Open Energy Info (EERE)

SurfaceManager SurfaceManager Jump to: navigation, search Property Name SurfaceManager Property Type Page Pages using the property "SurfaceManager" Showing 25 pages using this property. (previous 25) (next 25) A AZA-009168 + COCONINO NF + AZA-009169 + COCONINO NF + AZA-009170 + COCONINO NF + AZA-009171 + FOREST SERVICE + AZA-009172 + FOREST SERVICE + AZA-009173 + FOREST SERVICE + AZA-009174 + FOREST SERVICE + AZA-009175 + COCONINO NF + AZA-009176 + BUREAU OF LAND MGMT + AZA-009177 + FOREST SERVICE + AZA-009178 + FOREST SERVICE + AZA-009179 + FOREST SERVICE + AZA-009180 + FOREST SERVICE + AZA-009181 + FOREST SERVICE + AZA-009182 + FOREST SERVICE + AZA-009183 + FOREST SERVICE + AZA-009184 + FOREST SERVICE + AZA-009185 + FOREST SERVICE + AZA-009186 + COCONINO NF +

484

Calendar Year 2013  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

3 Office of Inspector General 
1000 3 Office of Inspector General 
1000 Independence Avenue, SW 
 Washington, DC 20585 202-586-4128 en Audit Report: OAS-FS-14-03 http://energy.gov/ig/downloads/audit-report-oas-fs-14-03 fs-14-03" class="title-link">Audit Report: OAS-FS-14-03

485

Report to Congress: Corridors and Rights-of-Way on Federal Lands...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Corridors and Rights-of-Way on Federal Lands Authority to grant, issue, or renew electric transmission ROWs on Federal land is held by the Forest Service (FS) of the U.S....

486

Sector 7  

NLE Websites -- All DOE Office Websites (Extended Search)

Division (XSD) of the Advanced Photon Source. Our research focus is the study of Ultrafast fs-laser excitation of matter, using x-ray scattering and spectroscopy techniques....

487

Generation of transform-limited rectangular pulses in a spectral compressor  

SciTech Connect

The generation of 100-fs transform-limited pulses with a rectangular envelope in a spectral compressor is demonstrated experimentally. The pulses are characterised by spectral interferometry. (control of radiation parameters)

Kalashyan, M A; Palandzhyan, K A; Esayan, G L; Muradyan, L Kh [Department of Physics, Yerevan State University, Yerevan (Armenia)

2010-12-09T23:59:59.000Z

488

Consolidated Financial Statements | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

March 20, 2000 March 20, 2000 Financial Statement: WR-FS-00-02 Report on Matters Identified at The Idaho Operations Office During The Audit of The Department of Energy's Consolidated Fiscal Year 1999 Financial Statements May 17, 1999 Financial Statement: WR-FS-09-04 Report on Matters Identified at the Oakland Operations Office during the Audit of The Department of Energy's Consolidated Fiscal year 1998 Financial Statements May 3, 1999 Finanacial Statement: WR-FS-09-03 Report on Matters Identified at the Richland Operations Office during the Audit of The Department of Energy's Consolidated Fiscal Year 1998 Financial Statements April 7, 1999 Finanacial Statement: WR-FS-99-02 Report on Matters Identified at the Albuquerque Operations Office During the Audit of the Department of Energy's Consolidated Fiscal Year 1998

489

Report on Matters Identified at Strategic Petroleum Reserve During...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Strategic Petroleum Reserve During Audit of Statement of Financial Position, CR-FS-96-03 Report on Matters Identified at Strategic Petroleum Reserve During Audit of Statement of...

490

Remedial System Performance Improvement for the 200-ZP-1_PW-1...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

as well as conceptual and mathematical model development in support of the 200-ZP-1 FS. * Dennis Faulk, EPA Region 10 * Arlene Tortoso, DOE RL * Mike Thompson, DOE RL * Briant...

491

Report on Matters Identified at the Richland Operations Office...  

NLE Websites -- All DOE Office Websites (Extended Search)

WR-FS-97-04 More Documents & Publications Report on Matters Identified at the Rocky Flats Field Office During the Audit of the Department's Consolidated Fiscal Year 1996...

492

Report on Matters Identified at the Rocky Flats Field Office...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Rocky Flats Field Office During the Audit of the Department's Consolidated Fiscal Year 1996 Financial Statements, WR-FS-97-03 Report on Matters Identified at the Rocky Flats Field...

493

Report on Matters Identified at the Richland Operations Office...  

NLE Websites -- All DOE Office Websites (Extended Search)

Position (as of September 30, 1995), IG-FS-96-01 Report on Matters Identified at the Rocky Flats Field Office During the Audit of the Department's Consolidated Fiscal Year 1996...

494

WRFS9901.PDF  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

WR-FS-99-01 REPORT ON MATTERS IDENTIFIED AT THE IDAHO OPERATIONS OFFICE DURING THE AUDIT OF THE DEPARTMENT'S CONSOLIDATED FISCAL YEAR 1998 FINANCIAL STATEMENTS AUDIT REPORT U.S....

495

Improvement of reliability of welding by in-process sensing and control: development of smart welding machines for girth welding of pipes. First progress report  

SciTech Connect

Progress is reported in a research program to improve the reliability of welding by developing smart welding machine which will be equipped with sensors, artificial intelligence, and actuators for reducing welding errors by one or two orders of magnitude. (FS)

Converti, J.; Dror, Y.; Hardt, D.E.; Masubuchi, K.; Paynter, H.M.; Unkel, W.C.

1979-11-30T23:59:59.000Z

496

(Development of automated welding process for field fabrication of thick walled pressure vessels). Technical progress report for period ending June 30, 1979  

SciTech Connect

The following activities for this period are reported: five welding processes (GTAW, GMAW, SAW, ESW, and EBW) are reviewed, torch design modifications were completed, improved joint designs were machined, and all wires for the project were ordered. (FS)

1979-01-01T23:59:59.000Z

497

Overview of the Quality and Completeness of Resource Assessment...  

NLE Websites -- All DOE Office Websites (Extended Search)

K K K KK KK x fs AES APEC BOB CRIB PI CWEEDS PERC HDR IRR ITCZ JMA LNG LPG MSW NBS NREL NSRDB PV RDF SOLMET SOLRAD WMO WRDC WTG Ac ronyms Atmospheric...

498

Complexity of the Critical Node Problem over trees  

E-Print Network (OSTI)

The optimal solution is required to minimize f(S) = ?{cij : i, j are .... We note that the reduction does not exponentially inflate the numbers in Unweighted-MCT,...

499

Multi-Instrument Comparison of Top-of-Atmosphere Reflected Solar Radiation  

Science Conference Proceedings (OSTI)

Observations from the Clouds and the Earths Radiant Energy System (CERES), Moderate Resolution Imaging Spectroradiometer (MODIS), Multiangle Imaging Spectroradiometer (MISR), and Sea-Viewing Wide-Field-of-View Sensor (SeaWiFS) between 2000 and ...

Norman G. Loeb; Bruce A. Wielicki; Wenying Su; Konstantin Loukachine; Wenbo Sun; Takmeng Wong; Kory J. Priestley; Grant Matthews; Walter F. Miller; R. Davies

2007-02-01T23:59:59.000Z

500

Development of a New Mid-infrared Source Pumped by an Optical Parametric Chirped-pulse Amplifier.  

E-Print Network (OSTI)

??The mid-infrared (MIR) system presented in the thesis is based on a sub-100-fs erbium-doped fiber laser operating at 1.55 m. The output of the laser (more)

Pelletier, Etienne

2013-01-01T23:59:59.000Z