Sample records for moran rt marchand

  1. Comments from Congressman James P. Moran, 8th District of Virginia...

    Office of Environmental Management (EM)

    from Congressman James P. Moran, 8th District of Virginia Supporting the Comments from the City of Alexandria on PEPCO's Intention to Commence Planned Transmission Outages Comments...

  2. Cavitation in normal liquid helium 3 F. Caupin, P. Roche, S. Marchand and S. Balibar

    E-Print Network [OSTI]

    Caupin, Frédéric

    Cavitation in normal liquid helium 3 F. Caupin, P. Roche, S. Marchand and S. Balibar Laboratoire de 24 rue Lhomond 75231 Paris Cedex 05, France We have studied cavitation, i.e. bubble nucleation, cavitation is found to be stochastic, with a cavitation probability 0.5 at a given value of the sound

  3. Anonymity and CSP for Voting Systems Murat Moran, James Heather, Steve Schneider

    E-Print Network [OSTI]

    Doran, Simon J.

    Anonymity and CSP for Voting Systems Murat Moran, James Heather, Steve Schneider Department Processes (CSP). In addition, we formalise conventional voting system with CSP and analyse whether our and the weak anonymity is more suitable specification for the voting processes. Keywords: anonymity, CSP

  4. SF 6432-RT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements RecentlyElectronicResourcesjobs RunningSEAB ReportsFESF SFFE6/14/11RT

  5. 1997 BNL Site Environmental Report E -1 Bari, R.A., Gordon, D., Moran, D., and Volkow, N.,

    E-Print Network [OSTI]

    APPENDIX E 1997 BNL Site Environmental Report E - 1 Bari, R.A., Gordon, D., Moran, D., and Volkow, N., 1997. Report of the Ad Hoc Committee on Environmental, Safety, and Health Decision Making at Brookhaven National Laboratory (April 29, 1997). Brookhaven National Laboratory, 1997. Environmental

  6. A day at the museum: An augmented fine-art exhibit Anne Bationo Tillon*, Eric Marchand, Jean Laneurit, Fabien Servant, Isabelle Marchal, Pascal Houlier

    E-Print Network [OSTI]

    Boyer, Edmond

    A day at the museum: An augmented fine-art exhibit Anne Bationo Tillon*, Eric Marchand, Jean Rennes 1 ABSTRACT This paper examines how an augmented reality guide can enrich museum visits. The results we obtained form an experiment conducted for a museum exhibit. An ergonomic experimentation has

  7. One Click Focus with Eye-in-hand/Eye-to-hand Cooperation Claire Dune1,2, Eric Marchand1, Christophe Leroux2

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    One Click Focus with Eye-in-hand/Eye-to-hand Cooperation Claire Dune1,2, Eric Marchand1, Christophe of the regions of interest from all the views. An initialization step is proposed for a hybrid eye-in-hand/eye to be within the eye-to-hand field of view, whereas it may not be within the eye-in-hand one. The object model

  8. THEMATIC ISSUE ARTICLE: SYNTHESIS (rt9mheri1) Simulating a Model of Metabolic Closure

    E-Print Network [OSTI]

    -Bowden Gabriel Piedrafita Federico Moran Maria Luz Cardenas Francisco Montero Received: 14 March 2012-Marseille Universite, Marseille, France e-mail: acornish@imm.cnrs.fr G. Piedrafita F. Moran F. Montero Facultad

  9. marchand-99.PDF

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron4 Self-Scrubbing:,, , (Energy9 EvaluationWHITE ROCK LOS

  10. Rt Hon Danny Alexander MP Chief Secretary to the Treasury

    E-Print Network [OSTI]

    . It is perfectly legitimate to expect energy suppliers and users to bear these costs. Proper scrutiny for Energy Rt Hon Charles Hendry MP Minister of State for Energy Rt Hon George Osborne MP Chancellor of the Exchequer Rt Hon Dr Vince Cable MP Secretary of State for Business, Innovation and Skills and President

  11. moran-98.pdf

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron4 Self-Scrubbing:,, , (Energy97 UpperJoint StatisticsMicroporous77 A

  12. moran-99.PDF

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron4 Self-Scrubbing:,, , (Energy97 UpperJoint StatisticsMicroporous77

  13. RT-PCR cloning of expressed VSGs Harvesting cells

    E-Print Network [OSTI]

    Cross, George

    RT-PCR cloning of expressed VSGs Harvesting cells Starting material: 510x107 cells (BF) Centrifuge for at least 1 month). RNA extraction STAT-60 according to manufacturer's instructions. Resuspend RNA in 50 l of DEPC-treated water. Measuring the A260 will suggest a yield of ~ 100 g RNA from 108 cells

  14. Parallel Picoliter RT-PCR Assays Using Microfluidics

    E-Print Network [OSTI]

    Quake, Stephen R.

    Parallel Picoliter RT-PCR Assays Using Microfluidics Joshua S. Marcus,, W. French Anderson The development of microfluidic tools for high-throughput nucleic acid analysis has become a burgeoning area of research in the post-genome era. Here, we have developed a microfluidic chip to perform 72 parallel 450-p

  15. Simulating Rayleigh-Taylor (RT) instability using PPM hydrodynamics @scale on Roadrunner (u)

    SciTech Connect (OSTI)

    Woodward, Paul R [Los Alamos National Laboratory; Dimonte, Guy [Los Alamos National Laboratory; Rockefeller, Gabriel M [Los Alamos National Laboratory; Fryer, Christopher L [Los Alamos National Laboratory; Dimonte, Guy [Los Alamos National Laboratory; Dai, W [Los Alamos National Laboratory; Kares, R. J. [Los Alamos National Laboratory

    2011-01-05T23:59:59.000Z

    The effect of initial conditions on the self-similar growth of the RT instability is investigated using a hydrodynamics code based on the piecewise-parabolic-method (PPM). The PPM code was converted to the hybrid architecture of Roadrunner in order to perform the simulations at extremely high speed and spatial resolution. This paper describes the code conversion to the Cell processor, the scaling studies to 12 CU's on Roadrunner and results on the dependence of the RT growth rate on initial conditions. The relevance of the Roadrunner implementation of this PPM code to other existing and anticipated computer architectures is also discussed.

  16. LAL/RT 04-03 THE TESLA HIGH POWER COUPLER PROGRAM AT ORSAY

    E-Print Network [OSTI]

    Boyer, Edmond

    LAL/RT 04-03 April 2004 1 THE TESLA HIGH POWER COUPLER PROGRAM AT ORSAY T. Garvey, H. Borie, L, Université de Paris-Sud, B.P. 34, 91898 Orsay, France Abstract Within the general TESLA collaboration-Orsay are centred on the development of RF input couplers for the cavities of the TESLA linear collider study

  17. Low Power RT-Level Synthesis Techniques: A Tutorial Massoud Pedram and Afshin Abdollahi

    E-Print Network [OSTI]

    Pedram, Massoud

    1 Low Power RT-Level Synthesis Techniques: A Tutorial Massoud Pedram and Afshin Abdollahi Dept. of Electrical Engineering University of Southern California Abstract ­ Power consumption and power others. And, while the primary method used to date for reducing power has been supply voltage reduction

  18. Power Minimization Techniques at the RT-Level and Afshin Abdollahi and Massoud Pedram

    E-Print Network [OSTI]

    Pedram, Massoud

    1 Power Minimization Techniques at the RT-Level and Below Afshin Abdollahi and Massoud Pedram Dept. of Electrical Engineering University of Southern California Los Angeles, CA 90089 U.S.A. Abstract ­ Power consumption and power-related issues have become a first-order concern for most designs and loom

  19. A RT I C L E S Protein complexes containing CYFIP/Sra/PIR121

    E-Print Network [OSTI]

    Kirchhausen, Tomas

    A RT I C L E S Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling CYFIP (cytoplasmic fragile-X mental retardation interacting protein; Sra, PIR121), a clathrin heavy) and CYFIP1 and CYFIP2 (also known as Sra1 and PIR121, respectively)19 , which interact with the fragile

  20. Seattle Regulatory Pathways to Net Zero Water Phase 1 status RePoRt

    E-Print Network [OSTI]

    Seattle Regulatory Pathways to Net Zero Water Phase 1 status RePoRt prepared for: City of seattle these and other efforts, there remain a number of obstacles for seattle projects that seek net zero water goals at multiple jurisdictional scales to establish policies and pathways for seattle-based projects pursing net

  1. RT-Based Administrative Models for Community Cyber Security Information Sharing

    E-Print Network [OSTI]

    Sandhu, Ravi

    RT-Based Administrative Models for Community Cyber Security Information Sharing Ravi Sandhu, Khalid Zaman Bijon, Xin Jin, and Ram Krishnan Institute for Cyber Security & Department of Computer Science Institute for Cyber Security & Department of Electrical and Computer Engineering University of Texas at San

  2. f i na n c i a l r e p o rt Report of Management

    E-Print Network [OSTI]

    Notes To Consolidated Financial Statements A Significant Accounting Policies B Accounting Changes Cf i na n c i a l r e p o rt Report of Management Report of Independent Accountants Management Discussion Consolidated Financial Statements Earnings Financial Position Cash Flows Stockholders' Equity

  3. University of Maryland Center for Environmental Science 2012 AnnuAl RepoRt

    E-Print Network [OSTI]

    Boynton, Walter R.

    Center for environmental Science has had a long history of studying Maryland's unique ecosystems from treatment and remediation, and aquaculture food sources with less environmental impact. I am proudUniversity of Maryland Center for Environmental Science 2012 AnnuAl RepoRt #12;annUal rEport 2012

  4. Modeling benzene plume elongation mechanisms exerted by ethanol using RT3D with a general

    E-Print Network [OSTI]

    Alvarez, Pedro J.

    Modeling benzene plume elongation mechanisms exerted by ethanol using RT3D with a general substrate ethanol on benzene fate and transport in fuel-contaminated groundwater and to discern the most influential benzene plume elongation mechanisms. The model, developed as a module for the Reactive Transport in 3

  5. RobeRt & LauRie bean taishoff inciting a MoRe incLusive

    E-Print Network [OSTI]

    McConnell, Terry

    RobeRt & LauRie bean taishoff inciting a MoRe incLusive coLLege caMpus syRacuse univeRsity scho. Thanks to her expertise--and the generosity of Robert Taishoff '86 and Laurie Bean Taishoff '84--the

  6. BLIND RT60 ESTIMATION ROBUST ACROSS ROOM SIZES AND SOURCE DISTANCES Baldwin Dumortier1,2,3

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    BLIND RT60 ESTIMATION ROBUST ACROSS ROOM SIZES AND SOURCE DISTANCES Baldwin Dumortier1 be blindly es- timated from a speech or music signal. Current methods often implicitly assume sound sources. This paper features two contributions. Firstly, we propose a blind RT60 estimation method

  7. Practice Problems Moran & Shapiro, 5th Edition

    E-Print Network [OSTI]

    by calculating the work for an adiabatic & reversible (isentropic) pump, and apply a pump efficiency of 70CoolingWater, boiler mFlueGas, etc. 3 #12;Start by filling in the STATES column h1 and s1 = Table A-4 s2s = s1 x2s

  8. Extra Problems Moran & Shapiro, 5th Edition

    E-Print Network [OSTI]

    Erat Demonstrandum. Homework Problem 5.18: Hint: Carnot cycles are reversible cycles operating between from 1:0 to 1; ranges from 0:0 to 1). The C.O.P.s of reversible cycles between two reservoirs are given to absolute tem- peratures! Practice Problem 5.20: Real cycles have lower C.O.P.s than reversible cycles

  9. Assoc Vice Chancellor & Karen Massetti Moran

    E-Print Network [OSTI]

    Saldin, Dilano

    /Meetings Exit Interviews Filing/Organization Records Management/Retention Public Records Requests Purchasing SERVICES Carla Sagert IS Comp Srvc Spec INFORMATION SERVICES Business Process & Project Management Data Analysis & Reporting Department Systems & Computing Infrastructure Management Campus/Department Interfaces

  10. Dermot Moran List of Publications2011

    E-Print Network [OSTI]

    . ISBN: 0-74-5621228-X/ ISBN: 0-7456-2122-8 (pbk). Reviews: Stephen Mulhall, `Tangled Roots of Original Gorner) `Gnomic Truth: A Review Article,' Milltown Studies 47 (2001), pp. 96-105 (Tom Wilson) Professor. 93-100 (Tom Rockmore) Thesis Eleven Vol. 69 No. 1 (May 2002), pp. 99-126 (Andrew Dawson) Psychologist

  11. Dermot Moran List of Publications2011

    E-Print Network [OSTI]

    ). Reviews: i. Stephen Mulhall, `Tangled Roots of Original Thoughts,' Times Higher Education Supplement, (7th 47 (2001), pp. 96-105 (Tom Wilson) xiv. `The Many Faces of Phenomenology A Critical Notice (March 2003), pp. 93-100 (Tom Rockmore) xv. Thesis Eleven Vol. 69 No. 1 (May 2002), pp. 99-126 (Andrew

  12. Moran Eye Center Translational Research Laboratories

    E-Print Network [OSTI]

    Marc, Robert E.

    Exit Security Point Floor Entry Point Fume Hood Wall Display Surface 5'-0" Diameter Wheel Chair Turn Graphic Scale Scale: 1" = 100' Location and Adjacency Plan Site Plan Plan Key Building Entry Point Pedestrian Entry Point Bicyles Entry Point Light Rail Station Plan Key #12;Level 1 Drawing Scale: 1/16" = 1

  13. Practice Problems Moran & Shapiro, 5th Edition

    E-Print Network [OSTI]

    F 1.6766 1.6576 to obtain h1 = 1433.2 BTU/lbm s1 = 1.6458 BTU/lbm-o R We always start by calculating the adiabatic and reversible (=isentropic) 1 #12;reference case (turb = 100%) first s2s = s1 = 1.6458 BTU/lbm-o R p2 = 3 psia = sg = 1.8861 BTU/lbm-o R s2s

  14. Chemical composition and RT[sub NDT] determinations for Midland weld WF-70

    SciTech Connect (OSTI)

    Nanstad, R.K.; McCabe, D.E.; Swain, R.L.; Miller, M.K. (Oak Ridge National Lab., TN (United States))

    1992-12-01T23:59:59.000Z

    The Heavy-Section Steal Irradiation Program Tenth Irradiation Series has the objective to investigate the affects of radiation on the fracture toughness of the low-upper-shelf submerged-arc welds (B W designation WF-70) in the reactor pressure vessel of the canceled Midland Unit 1 nuclear plant. This report discusses determination of variations in chemical composition And reference temperature (RT[sub NDT]) throughout the welds. Specimens were machined from different sections and through thickness locations in both the beltline and nozzle course welds. The nil-ductility transition temperatures ranged from [minus]40 to [minus]60[degrees]C ([minus]40 and [minus]76[degrees]F) while the RT[sub NDT]S, controlled by the Charpy behavior, varied from [minus]20 to 37[degrees]C ([minus]4 to 99[degrees]F). The upper-shelf energies varied from 77 to 108 J (57 to 80 ft-lb). The combined data revealed a mean 41-J (30-ft-lb) temperature of [minus]8[degrees]C (17[degrees]F) with a mean upper-shelf energy of 88 J (65 ft-lb). The copper contents range from 0.21 to 0.34 wt % in the beltline weld and from 0.37 to 0.46 wt % in the nozzle course weld. Atom probe field ion microscope analyses indicated substantial depletion of copper in the matrix but no evidence of copper clustering. Statistical analyses of the Charpy and chemical composition results as well as interpretation of the ASME procedures for RT[sub NDT] determination are discussed.

  15. RT in situ PCR detection of MART-1 and TRP-2 mRNA in formalin-fixed, paraffin-embedded tissues of melanoma and nevi.

    E-Print Network [OSTI]

    Itakura, Eijun; Huang, Rong-Rong; Wen, Duan-Ren; Paul, Eberhard; Wnsch, Peter H; Cochran, Alistair J

    2008-01-01T23:59:59.000Z

    primary and metastatic melanomas and keratinocytic tumorsPCR IHC TRP-2 RT in situ PCR IHC Primary melanoma in situinvasive Metastatic melanoma Melanocytic nevi Squamous cell

  16. Implementation and commissioning of an integrated micro-CT/RT system with computerized independent jaw collimation

    SciTech Connect (OSTI)

    Jensen, Michael D. [Department of Medical Biophysics, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A 3K7 (Canada)] [Department of Medical Biophysics, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A 3K7 (Canada); Hrinivich, W. Thomas; Jung, Jongho A. [Department of Physics and Astronomy, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A 3K7 (Canada)] [Department of Physics and Astronomy, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A 3K7 (Canada); Holdsworth, David W. [Imaging Research Laboratories, Robarts Research Institute, 100 Perth Drive, London, Ontario N6A 5K8 (Canada) [Imaging Research Laboratories, Robarts Research Institute, 100 Perth Drive, London, Ontario N6A 5K8 (Canada); Department of Medical Biophysics, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A 3K7 (Canada); Department of Surgery, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A 3K7 (Canada); Drangova, Maria [Imaging Research Laboratories, Robarts Research Institute, 100 Perth Drive, London, Ontario N6A 5K8, Canada and Department of Medical Biophysics, The University of Western Ontario 1151 Richmond Street, London, Ontario N6A 3K7 (Canada)] [Imaging Research Laboratories, Robarts Research Institute, 100 Perth Drive, London, Ontario N6A 5K8, Canada and Department of Medical Biophysics, The University of Western Ontario 1151 Richmond Street, London, Ontario N6A 3K7 (Canada); Chen, Jeff [Department of Physics and Engineering, London Regional Cancer Program, London Health Sciences Centre, 800 Commissioners Road East, London, Ontario N6A 5W9 (Canada) [Department of Physics and Engineering, London Regional Cancer Program, London Health Sciences Centre, 800 Commissioners Road East, London, Ontario N6A 5W9 (Canada); Department of Medical Biophysics, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A 3K7 (Canada); Department of Oncology, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A 3K7 (Canada); Wong, Eugene [Department of Physics and Astronomy, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A 3K7 (Canada) [Department of Physics and Astronomy, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A 3K7 (Canada); Department of Medical Biophysics, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A 3K7 (Canada); Department of Oncology, The University of Western Ontario, 1151 Richmond Street, London, Ontario N6A 3K7 (Canada); Department of Physics and Engineering, London Regional Cancer Program, London Health Sciences Centre, 800 Commissioners Road East, London, Ontario N6A 5W9 (Canada)

    2013-08-15T23:59:59.000Z

    Purpose: To design, construct, and commission a set of computer-controlled motorized jaws for a micro-CT/RT system to perform conformal image-guided small animal radiotherapy.Methods: The authors designed and evaluated a system of custom-built motorized orthogonal jaws, which allows the delivery of off-axis rectangular fields on a GE eXplore CT 120 preclinical imaging system. The jaws in the x direction are independently driven, while the y-direction jaws are symmetric. All motors have backup encoders, verifying jaw positions. Mechanical performance of the jaws was characterized. Square beam profiles ranging from 2 2 to 60 60 mm{sup 2} were measured using EBT2 film in the center of a 70 70 22 mm{sup 3} solid water block. Similarly, absolute depth dose was measured in a solid water and EBT2 film stack 50 50 50 mm{sup 3}. A calibrated Farmer ion chamber in a 70 70 20 mm{sup 3} solid water block was used to measure the output of three field sizes: 50 50, 40 40, and 30 30 mm{sup 2}. Elliptical target plans were delivered to films to assess overall system performance. Respiratory-gated treatment was implemented on the system and initially proved using a simple sinusoidal motion phantom. All films were scanned on a flatbed scanner (Epson 1000XL) and converted to dose using a fitted calibration curve. A Monte Carlo beam model of the micro-CT with the jaws has been created using BEAMnrc for comparison with the measurements. An example image-guided partial lung irradiation in a rat is demonstrated.Results: The averaged random error of positioning each jaw is less than 0.1 mm. Relative output factors measured with the ion chamber agree with Monte Carlo simulations within 2%. Beam profiles and absolute depth dose curves measured from the films agree with simulations within measurement uncertainty. Respiratory-gated treatments applied to a phantom moving with a peak-to-peak amplitude of 5 mm showed improved beam penumbra (80%20%) from 3.9 to 0.8 mm.Conclusions: A set of computer-controlled motorized jaws for a micro-CT/RT system were constructed with position reliably better than a tenth of a millimeter. The hardware system is ready for image-guided conformal radiotherapy for small animals with capability of respiratory-gated delivery.

  17. SOIL MIX REMEDIATION TECHNOLOGY (PROJECT SMiRT) In October 2007, Cambridge University launched the largest Technology Strategy

    E-Print Network [OSTI]

    Travis, Adrian

    launched the largest Technology Strategy Board funded project on Contaminated Land Remediation Technologies Ash Association) and four materials Suppliers (Amcol Minerals Europe, Richard Baker Harrison, Kentish Minerals and Civil & Marine Holdings). Project SMiRT aims to achieve significant technical advancement

  18. Automatic Systole-Diastole Classification of Mitral Valve Complex from RT-3D Echocardiography based on Multiresolution Processing

    E-Print Network [OSTI]

    Wong, Kenneth K.Y.

    Automatic Systole-Diastole Classification of Mitral Valve Complex from RT-3D Echocardiography based, The Chinese University of Hong Kong, Hong Kong ABSTRACT Mitral valve repair is one of the most prevalent operations for various mitral valve conditions. Echocardiography, being famous for its low-cost, non

  19. Oceanography Vol.21, No.392 W o r k s h o p r e p o rt

    E-Print Network [OSTI]

    Buesseler, Ken

    limits the extent of carbon sequestration from the atmo- sphere. The mechanisms controlling both the impact of ongoing climate and ocean circulation changes on this carbon sequestration. To identify gapsOceanography Vol.21, No.392 W o r k s h o p r e p o rt Controls on organic Carbon export

  20. Diagnostic evaluation of a multiplexed RT-PCR microsphere array assay for the detection of foot-and-mouth disease virus and look-alike disease viruses

    SciTech Connect (OSTI)

    Hindson, B J; Reid, S M; Baker, B R; Ebert, K; Ferris, N P; Bentley Tammero, L F; Lenhoff, R J; Naraghi-Arani, P; Vitalis, E A; Slezak, T R; Hullinger, P J; King, D P

    2007-07-26T23:59:59.000Z

    A high-throughput multiplexed assay was developed for the differential laboratory diagnosis of foot-and-mouth disease virus (FMDV) from viruses which cause clinically similar diseases of livestock. This assay simultaneously screens for five RNA and two DNA viruses using multiplexed reverse transcription PCR (mRT-PCR) amplification coupled with a microsphere hybridization array and flow-cytometric detection. Two of the seventeen primer-probe sets included in this multiplex assay were adopted from previously characterized real-time RT-PCR (rRT-PCR) assays for FMDV. The diagnostic accuracy of the mRT-PCR was evaluated using 287 field samples, including 248 (true positive n= 213, true negative n=34) from suspect cases of foot-and-mouth disease collected from 65 countries between 1965 and 2006 and 39 true negative samples collected from healthy animals. The mRT-PCR assay results were compared with two singleplex rRT-PCR assays, using virus isolation with antigen-ELISA as the reference method. The diagnostic sensitivity of the mRT-PCR assay for FMDV was 93.9% [95% C.I. 89.8-96.4%], compared to 98.1% [95% C.I. 95.3-99.3%] for the two singleplex rRT-PCR assays used in combination. In addition, the assay could reliably differentiate between FMDV and other vesicular viruses such as swine vesicular disease virus and vesicular exanthema of swine virus. Interestingly, the mRT-PCR detected parapoxvirus (n=2) and bovine viral diarrhea virus (n=2) in clinical samples, demonstrating the screening potential of this mRT-PCR assay to identify viruses in FMDV-negative material not previously recognized using focused single-target rRT-PCR assays.

  1. Regional measurements of /sup 14/Cmisonidazole distribution and blood flow in subcutaneous RT-9 experimental tumors

    SciTech Connect (OSTI)

    Blasberg, R.; Horowitz, M.; Strong, J.; Molnar, P.; Patlak, C.; Owens, E.; Fenstermacher, J.

    1985-04-01T23:59:59.000Z

    Regional (/sup 14/C)misonidazole-derived radioactivity (MISO*) was measured by quantitative autoradiography in s.c. RT-9 experimental tumors 0.5, 2, and 4 h after an i.v. bolus (25 mg) and constant infusion (10 mg/h) in rats. Misonidazole (MISO) concentration in plasma, tumor, and other tissues was also measured by high-pressure liquid chromatography. The distribution of MISO* in the tumors always resulted in a characteristic pattern with high peripheral and low central values. The high-activity regions in the tumor rim achieved tissue: plasma MISO* activity ratios of 0.97 and 2.2 by 0.5 and 4 h, respectively; for central tumor regions, this ratio was 0.20 and 0.32 for the same periods, respectively. The limited distribution of MISO* to central tumor regions could be correlated to low values of blood flow (measured with (/sup 131/I)iodoantipyrine) and to diffusion from peripheral tumor regions. Low blood flow in the central regions of these tumors will significantly limit the distribution of MISO and other drugs to viable-appearing cells in these areas and could account in part for the failures of chemotherapy in certain solid tumors. Pharmacokinetic modeling indicates that 1 to 9 h may be necessary for MISO concentrations in some tumor regions to reach 50% of that in plasma.

  2. Detection of GRB 090618 with RT-2 Experiment Onboard the Coronas-Photon Satellite

    E-Print Network [OSTI]

    Rao, A R; Hingar, M K; Agrawal, V K; Chakrabarti, S K; Nandi, A; Debnath, D; Kotoch, T B; Sarkar, R; Chidambaram, T R; Vinod, P; Sreekumar, S; Kotov, Y D; Buslov, A S; Yurov, V N; Tyshkevich, V G; Arkhangelskij, A I; Zyatkov, R A; Naik, Sachindra

    2010-01-01T23:59:59.000Z

    We present the results of an analysis of the prompt gamma-ray emission from GRB 090618 using the RT-2 Experiment onboard the Coronas-Photon satellite. GRB 090618 shows multiple peaks and a detailed study of the temporal structure as a function of energy is carried out. As the GRB was incident at an angle of 77 degree to the detector axis, we have generated appropriate response functions of the detectors to derive the spectrum of this GRB. We have augmented these results using the publicly available data from the Swift BAT detector and show that a combined spectral analysis can measure the spectral parameters quite accurately. We also attempt a spectral and timing analysis of individual peaks and find evidence for a systematic change in the pulse emission characteristics for the successive pulses. In particular, we find that the peak energy of the spectrum, E_p, is found to monotonically decrease with time, for the successive pulses of this GRB.

  3. STR82: combined string and user-interface library for VAX/VMS, RSX-11M, and RT-11

    SciTech Connect (OSTI)

    Garbarini, J.P. Jr.

    1982-08-10T23:59:59.000Z

    A combined string and user interface library was written to aid programmers in writing portable code. The library has been implemented under Digital Equipment Corporation (DEC) VAX/VMS, RSX-11M, and RT-11 operations systems for use with FORTRAN programs. This is a reference manual for STR82 which is a library containing string routines and user interface routines. Versions of the library exist for use with VAX-FORTRAN programs running under VAX/VMS and for use with either FORTRAN IV-PLUS or FORTRAN IV programs using PDP-11's running RSX-11M or RT-11. The manual is for programmers using the library on one or more of these systems. Included are the logical functions of the routines and their calling sequences.

  4. RT3D Reaction Modules for Natural and Enhanced Attenuation of Chloroethanes, Chloroethenes, Chloromethanes, and Daughter Products

    SciTech Connect (OSTI)

    Johnson, Christian D.; Truex, Michael J.

    2006-07-25T23:59:59.000Z

    This document describes a suite of MNA/EA reaction modules that were developed for addressing complex chlorinated solvent reactions using RT3D. As an introduction, an overview of these MNA/EA reaction modules is presented, including discussions of similarities between reaction modules, the purpose of key reaction parameters, and important considerations for using the reaction modules. Subsequent sections provide the details of the reaction kinetics (conceptual model and equations), data input requirements, and example (batch reactor) results for each reaction module. This document does not discuss reaction module implementation or validation; such information will accompany the software in the form of release notes or a supplement to the RT3D manual.

  5. Reduced Toxicity With Intensity Modulated Radiation Therapy (IMRT) for Desmoplastic Small Round Cell Tumor (DSRCT): An Update on the Whole Abdominopelvic Radiation Therapy (WAP-RT) Experience

    SciTech Connect (OSTI)

    Desai, Neil B. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)] [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Stein, Nicholas F. [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)] [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); LaQuaglia, Michael P. [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)] [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Alektiar, Kaled M. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)] [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Kushner, Brian H.; Modak, Shakeel; Magnan, Heather M. [Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)] [Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Goodman, Karyn [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)] [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Wolden, Suzanne L., E-mail: woldens@mskcc.org [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)

    2013-01-01T23:59:59.000Z

    Purpose: Desmoplastic small round cell tumor (DSRCT) is a rare malignancy typically involving the peritoneum in young men. Whole abdominopelvic radiation therapy (WAP-RT) using conventional 2-dimensional (2D) radiation therapy (RT) is used to address local recurrence but has been limited by toxicity. Our objectives were to assess the benefit of intensity modulated radiation therapy (IMRT) on toxicity and to update the largest series on radiation for DSRCT. Methods and Materials: The records of 31 patients with DSRCT treated with WAP-RT (22 with 2D-RT and 9 with IMRT) between 1992 and 2011 were retrospectively reviewed. All received multi-agent chemotherapy and maximal surgical debulking followed by 30 Gy of WAP-RT. A further focal boost of 12 to 24 Gy was used in 12 cases. Boost RT and autologous stem cell transplantation were nearly exclusive to patients treated with 2D-RT. Toxicities were assessed with the Common Terminology Criteria for Adverse Events. Dosimetric analysis compared IMRT and simulated 2D-RT dose distributions. Results: Of 31 patients, 30 completed WAP-RT, with a median follow-up after RT of 19 months. Acute toxicity was reduced with IMRT versus 2D-RT: P=.04 for gastrointestinal toxicity of grade 2 or higher (33% vs 77%); P=.02 for grade 4 hematologic toxicity (33% vs 86%); P=.01 for rates of granulocyte colony-stimulating factor; and P=.04 for rates of platelet transfusion. Post treatment red blood cell and platelet transfusion rates were also reduced (P=.01). IMRT improved target homogeneity ([D05-D95]/D05 of 21% vs 46%) and resulted in a 21% mean bone dose reduction. Small bowel obstruction was the most common late toxicity (23% overall). Updated 3-year overall survival and progression-free survival rates were 50% and 24%, respectively. Overall survival was associated with distant metastasis at diagnosis on multivariate analysis. Most failures remained intraperitoneal (88%). Conclusions: IMRT for consolidative WAP-RT in DSRCT improves hematologic toxicity in particular. Although the long-term efficacy of current treatment options remains disappointing, the improved therapeutic index of IMRT may aid in generalizing its use and allowing the addition of novel approaches such as intraperitoneal immunotherapy.

  6. STUDEN T FIN ANCIAL AID AND SCHO LARSHIP S SE RVICE SUPPO RT SUCC ESS 1278 University of Oregon, Eugene OR 97403-1278 http://financialaid.uoregon.edu

    E-Print Network [OSTI]

    Oregon, University of

    STUDEN T FIN ANCIAL AID AND SCHO LARSHIP S SE RVICE SUPPO RT SUCC ESS 1278 University of Oregon #12;STUDEN T FIN ANCIAL AID AND SCHO LARSHIP S SE RVICE SUPPO RT SUCC ESS 1278 University of Oregon

  7. Assignment of the human RT6 gene to 11q13 by PCR screening of somatic cell hybrids and in situ hybridization

    SciTech Connect (OSTI)

    Koch-Nolte, F.; Haag, F.; Kuehl, M.; Thiele, H.G.; Singh, S. (Univ. Hospital, Hamburg (Germany)); Van Heyningen, V. (Medical Research Council, Edinburgh (United Kingdom)); Hoovers, J. (Univ. of Amsterdam (Netherlands)); Grzeschik, K.H. (Univ. of Marburg (Germany))

    1993-11-01T23:59:59.000Z

    RT6 is a T cell membrane protein that has attracted interest because a defect in RT6 expression is associated with susceptibility to autoimmune type I diabetes in DP-BB rats and NOD mice. Using PCR screening of human/rodent somatic cell hybrids and fluorescence in situ hybridization, the authors have determined that the gene for the human RT6 homologue is located at 11q13, centromeric to the gene for tyrosinase (TYR, albino locus) and telomeric to that for fibroblast growth factor 4 (FGF4). The data suggest that the human RT6 gene constitutes a new linkage group with TYR and the gene for olfactory marker protein (OMP) on 11q, which has a counterpart in mouse chromosome 7. Thus, in the human, the RT6 locus is dissociated from the hemoglobin [beta] chain locus (HBB) and its neighboring conserved linkage group at 11q15, in contrast to the mouse, in which RT6 shows a tighter linkage to Hbb than to Tyr. The results support the conclusion that there has been considerable intrachromosomal reshuffling of linked genes since the divergence of primates and rodents. 9 refs., 1 fig.

  8. Air Entrainment by Viscous Contact Lines Antonin Marchand1

    E-Print Network [OSTI]

    an unexpectedly weak dependence of entrainment speed on liquid viscosity, pointing towards a crucial role the breakup of the air film strongly resembles the dewetting of a liquid film, the wetting speeds are larger only affects the gas density, and thus the speed of sound and the mean free path in the gas. A similar

  9. CURRICULUM VITAE ROSALYN J MORAN PhD

    E-Print Network [OSTI]

    Moran, Rosalyn

    Electronic Engineer Fabrication Design June 2003 - Oct 2003 European HQ Analog Devices Inc. Limerick, Ireland EDUCATION PhD Electronic Engineering 2004 - 2007 (Viva Voce, Jan 2008) School of Electrical, Electronic Dublin, Ireland Bachelor of Engineering (Electronic) First Class Honours 2000 - 2004 School of Electrical

  10. Dermot Moran Conference Presentations since 1979 CONFERENCE PRESENTATIONS

    E-Print Network [OSTI]

    by the Australasian Phenomenology and Hermeneutics Association (APHA) in collaboration with Philosophy at Murdoch-world. Australasian Phenomenology and Hermeneutics Association (APHA) in collaboration with Philosophy at Murdoch

  11. City of Moran, Kansas (Utility Company) | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual Siteof EnergyInnovationin Urban TransportMartinsville,Minidoka, IdahoCity ofCity of

  12. Dose optimization with first-order total-variation minimization for dense angularly sampled and sparse intensity modulated radiation therapy (DASSIM-RT)

    SciTech Connect (OSTI)

    Kim, Hojin; Li Ruijiang; Lee, Rena; Goldstein, Thomas; Boyd, Stephen; Candes, Emmanuel; Xing Lei [Department of Electrical Engineering, Stanford University, Stanford, California 94305-9505 (United States) and Department of Radiation Oncology, Stanford University, Stanford, California 94305-5847 (United States); Department of Radiation Oncology, Stanford University, Stanford, California 94305-5847 (United States); Department of Radiation Oncology, Ehwa University, Seoul 158-710 (Korea, Republic of); Department of Electrical Engineering, Stanford University, Stanford, California 94305-9505 (United States); Department of Statistics, Stanford University, Stanford, California 94305-4065 (United States); Department of Radiation Oncology, Stanford University, Stanford, California 94305-5304 (United States)

    2012-07-15T23:59:59.000Z

    Purpose: A new treatment scheme coined as dense angularly sampled and sparse intensity modulated radiation therapy (DASSIM-RT) has recently been proposed to bridge the gap between IMRT and VMAT. By increasing the angular sampling of radiation beams while eliminating dispensable segments of the incident fields, DASSIM-RT is capable of providing improved conformity in dose distributions while maintaining high delivery efficiency. The fact that DASSIM-RT utilizes a large number of incident beams represents a major computational challenge for the clinical applications of this powerful treatment scheme. The purpose of this work is to provide a practical solution to the DASSIM-RT inverse planning problem. Methods: The inverse planning problem is formulated as a fluence-map optimization problem with total-variation (TV) minimization. A newly released L1-solver, template for first-order conic solver (TFOCS), was adopted in this work. TFOCS achieves faster convergence with less memory usage as compared with conventional quadratic programming (QP) for the TV form through the effective use of conic forms, dual-variable updates, and optimal first-order approaches. As such, it is tailored to specifically address the computational challenges of large-scale optimization in DASSIM-RT inverse planning. Two clinical cases (a prostate and a head and neck case) are used to evaluate the effectiveness and efficiency of the proposed planning technique. DASSIM-RT plans with 15 and 30 beams are compared with conventional IMRT plans with 7 beams in terms of plan quality and delivery efficiency, which are quantified by conformation number (CN), the total number of segments and modulation index, respectively. For optimization efficiency, the QP-based approach was compared with the proposed algorithm for the DASSIM-RT plans with 15 beams for both cases. Results: Plan quality improves with an increasing number of incident beams, while the total number of segments is maintained to be about the same in both cases. For the prostate patient, the conformation number to the target was 0.7509, 0.7565, and 0.7611 with 80 segments for IMRT with 7 beams, and DASSIM-RT with 15 and 30 beams, respectively. For the head and neck (HN) patient with a complicated target shape, conformation numbers of the three treatment plans were 0.7554, 0.7758, and 0.7819 with 75 segments for all beam configurations. With respect to the dose sparing to the critical structures, the organs such as the femoral heads in the prostate case and the brainstem and spinal cord in the HN case were better protected with DASSIM-RT. For both cases, the delivery efficiency has been greatly improved as the beam angular sampling increases with the similar or better conformal dose distribution. Compared with conventional quadratic programming approaches, first-order TFOCS-based optimization achieves far faster convergence and smaller memory requirements in DASSIM-RT. Conclusions: The new optimization algorithm TFOCS provides a practical and timely solution to the DASSIM-RT or other inverse planning problem requiring large memory space. The new treatment scheme is shown to outperform conventional IMRT in terms of dose conformity to both the targetand the critical structures, while maintaining high delivery efficiency.

  13. Mechanistic Evaluation of the Pros and Cons of Digital RT-LAMP for HIV1 Viral Load Quantification on a Microfluidic Device and

    E-Print Network [OSTI]

    Ismagilov, Rustem F.

    to manipulate many single molecules in parallel through a two-step digital process. In the first step weMechanistic Evaluation of the Pros and Cons of Digital RT-LAMP for HIV1 Viral Load Quantification on a Microfluidic Device and Improved Efficiency via a Two-Step Digital Protocol Bing Sun, Feng Shen, Stephanie E

  14. The implementation of non pharmaceutical interventions(NPIs) in smaller to large communities and its relation to RO and R(t) during HIN1 pandemic 2009

    E-Print Network [OSTI]

    Hashmi, Sahar

    2011-01-01T23:59:59.000Z

    This thesis focuses on the use of non-pharmaceutical interventions (NPIs) during the time of the 2009 HINI pandemic and its possible relation to RO and R(t). RO is defined as the mean number of people that a newly infected ...

  15. Metallicity Distribution in the Milky Way Disk Dana S. Balser, R.T. Rood, T.M. Bania, L.D. Anderson

    E-Print Network [OSTI]

    Balser, Dana S.

    al. (2006) Sun GC #12;Electron Temperature Radial Gradient K200)(T R)49257()4986406(T e galeMetallicity Distribution in the Milky Way Disk Dana S. Balser, R.T. Rood, T.M. Bania, L.D. Anderson Photo: Harry Morton #12;HII Region Electron Temperature and Metallicity Shaver et al. (1983) 1.15 e C L

  16. arXiv:1105.4207v1[math.RT]21May2011 Affine and degenerate affine BMW algebras: The center

    E-Print Network [OSTI]

    Ram, Arun

    arXiv:1105.4207v1[math.RT]21May2011 Affine and degenerate affine BMW algebras: The center Zajj and affine BMW algebras arise naturally in the context of Schur- Weyl duality for orthogonal and symplectic Lie algebras and quantum groups, respectively. Cyclotomic BMW algebras, affine Hecke algebras

  17. Methanol Masers Observations in the 3-mm Bandwidth at the Radio Telescope RT-22 CrAO

    E-Print Network [OSTI]

    S. Yu. Zubrin; A. V. Antyufeyev; V. V. Myshenko; V. M. Shulga

    2007-12-10T23:59:59.000Z

    We report the beginning of the astronomical masers investigations in the 3-mm bandwidth at the radio telescope RT-22 (CrAO, Ukraine). For this purpose the special complex for maser lines investigation in 85...115 GHz frequency band is developed. It is made on the base of the low noise cryogenic Shottky-diode receiver and the high resolution Fourier-spectrometer. The cryogenic receiver has the DSB noise temperature less than 100K. The spectral channel separation of the Fourier-spectrometer is about 4kHz and the spectrometer bandwidth is 8 MHz. Results of maser observations of 8$^{0}-7^{1} $A$^{+}$ transition of methanol (95.169 GHz) towards DR-21(OH), DR-21W and NGC7538 are in good agreement with early obtained results by other authors. On the basis of the analysis of the location of masers in the NGC7538 direction we can assume that the origin of all known class I methanol masers in this region is connected with existing molecular outflows from young stars.

  18. SF 6432-RT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    version electronically. (b) Training Requirements. Any Contractor personnel who will enter a government site to perform work shall have completed all of the ES&H training...

  19. Austin(2)-RT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041cloth DocumentationProductsAlternativeOperationalAugust August 2015 Events August 2015 eventStratus

  20. SF 6432-RT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements RecentlyElectronicResourcesjobs RunningSEAB ReportsFESF SFFE6/14/11

  1. VISUAl IDeNtItY & BRAND USAge the logo Y E A R O F T H E A RTS AT DA RT M O U T H the logo

    E-Print Network [OSTI]

    Myers, Lawrence C.

    VISUAl IDeNtItY & BRAND USAge #12;2 the logo Y E A R O F T H E A RTS AT DA RT M O U T H the logo 3 Y E A R O F T H E A RTS AT DA RT M O U T H Features the Year of the Arts at Dartmouth logo consists of the "Y" in YeAR. l o g o t Y P e I C o N #12;4 the logo Y E A R O F T H E A RTS AT DA RT M O U T H

  2. United States Department of t he Int erior J.A Krug Se creta rJ Fish and -lildlife Service, Albe rt {,1. Da~, Dir~Gtor Yi

    E-Print Network [OSTI]

    - ~uick freez ing and cold storaGe of- fish . 7 pp ., 1 cha rt , Decembe r 1946 ~ !I One of a s eries Get'man fishing industry . y Rep c'rt I - Fish process ing machinery .. u nte rview with He rr Baade ri7 7 pp ., De cembe r 1946 . Certa in a spects of t he GE rman fishing industry. 1/ Report II

  3. Development and Characterization of A Multiplexed RT-PCR Species Specific Assay for Bovine and one for Porcine Foot-and-Mouth Disease Virus Rule-Out

    SciTech Connect (OSTI)

    Smith, S M; Danganan, L; Tammero, L; Vitalis, B; Lenhoff, R; Naraghi-arani, P; Hindson, B

    2007-08-06T23:59:59.000Z

    Lawrence Livermore National Laboratory (LLNL), in collaboration with the Department of Homeland Security (DHS) and the United States Department of Agriculture (USDA), Animal and Plant Health Inspection Services (APHIS) has developed candidate multiplexed assays that may potentially be used within the National Animal Health Laboratory Network (NAHLN), the National Veterinary Services Laboratory (Ames, Iowa) and the Plum Island Animal Disease Center (PIADC). This effort has the ability to improve our nation's capability to discriminate between foreign animal diseases and those that are endemic using a single assay, thereby increasing our ability to protect food and agricultural resources with a diagnostic test which could enhance the nation's capabilities for early detection of a foreign animal disease. In FY2005 with funding from the DHS, LLNL developed the first version (Version 1.0) of a multiplexed (MUX) nucleic-acid-based RT-PCR assay that included signatures for foot-and-mouth disease virus (FMDV) detection with rule-out tests for two other foreign animal diseases (FADs) of swine, Vesicular Exanthema of Swine (VESV) and Swine Vesicular Disease Virus (SVDV), and four other domestic viral diseases Bovine Viral Diarrhea Virus (BVDV), Bovine Herpes Virus 1 (BHV-1), Bluetongue virus (BTV) and Parapox virus complex (which includes Bovine Papular Stomatitis Virus [BPSV], Orf of sheep, and Pseudocowpox). In FY06, LLNL has developed Bovine and Porcine species-specific panel which included existing signatures from Version 1.0 panel as well as new signatures. The MUX RT-PCR porcine assay for detection of FMDV includes the FADs, VESV and SVD in addition to vesicular stomatitis virus (VSV) and porcine reproductive and respiratory syndrome (PRRS). LLNL has also developed a MUX RT-PCR bovine assay for detection of FMDV with rule out tests for the two bovine FADs malignant catarrhal fever (MCF), rinderpest virus (RPV) and the domestic diseases vesicular stomatitis virus (VSV), bovine viral diarrhea virus (BVDV), infectious bovine rhinotracheitus virus (BHV-1), bluetongue virus (BTV), and the Parapox viruses (which are of two bovine types) bovine papular stomatitis virus (BPSV) and psuedocowpox (PCP). A timeline for this development is presented in Table 1. The development of the Version 1.0 panel for FMDV rule-out and the most current efforts aimed to designed species specific panels has spanned over 2 1/2 years with multiple collaborative partnerships. This document provides a summary of the development, testing and performance data at OIE Stage 1 Feasibility into Stage 2 Assay Development and Standardization1 (see Table 2), gathered as of June 30th, 2007 for the porcine and bovine MUX assay panels. We present an overview of the identification and selection of candidate genetic signatures, the assay development process, and preliminary performance data for each of the individual signatures as characterized in the multiplexed format for the porcine and bovine panels. The Stage 1 Feasibility data of the multiplexed panels is presented in this report also includes relevant data acquired from the Version 1.0 panel as supporting information where appropriate. In contrast to last years effort, the development of the bovine and porcine panels is pending additional work to complete analytical characterization of FMDV, VESV, SVD, RPV and MCF. The signature screening process and final panel composition impacts this effort. The unique challenge presented this year was having strict predecessor limitations in completing characterization, where efforts at LLNL must precede efforts at PIADC, such challenges were alleviated in the 2006 reporting by having characterization data from the interlaboratory comparison and at Plum Island under AgDDAP project. We will present an addendum at a later date with additional data on the characterization of the porcine and bovine multiplex assays when that data is available. As a summary report, this document does not provide the details of signature generation, evaluation, and testing, nor does it provide spec

  4. Microsoft PowerPoint - Marchand_ARM_STM_2008_Poster_Classification_II.ppt

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHighand RetrievalsFinalModule8.pptStates A Comparison of Simulated

  5. Frequency and longitudinal trends of household care product use Rebecca E. Moran a

    E-Print Network [OSTI]

    Leistikow, Bruce N.

    SUPERB Indoor environment d-limonene a b s t r a c t The use of household cleaning products and air infiltrating to the indoor environment to form potentially toxic secondary pollutants. Although realistic, frequencies of use of eight types of household cleaning products and air fresheners and the performance

  6. MICRON MOUSE IMAGING SYSTEM The Micron Mouse Imaging System is a Core Resource for the Moran

    E-Print Network [OSTI]

    Marc, Robert E.

    arm and PC cradle (J) Micron camera-amplifier unit (Toshiba IK-TU51CU) (D) Micron integrated xenon tolerance, reporting requirements IP Urethane (non-recovery use only) ... wide tolerance, slow acting, carcinogen Topical: 1% lidocaine in 0.1% NaCl prepared by user or equivalent from pharmacy Vaporizer

  7. Linking Video Segments to Relevant Wikipedia Content Victor Lavrenko, Johanna Moore, Sean Moran

    E-Print Network [OSTI]

    Edinburgh, University of

    Mostly inaccessible to the public will take 80+ years to digitise long, monolithic programs to Wikipedia Good fit for GPU-based implementation Identify scenes using visual/audio similarity, motion

  8. Moran & Shapiro, 5th Edition Oct. 27 to Nov. 3, 2004

    E-Print Network [OSTI]

    and adiabatic calculation s1 = 1.9263 BTU/lbm-o R from Table A-4E s2s = s1 = 1.9263 BTU/lbm-o R Interpolating

  9. Comments from Congressman James P. Moran, 8th District of Virginia

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 111 1,613PortsmouthBartlesville EnergyDepartment. CashDay-June 22, 2015 |at theSupporting the

  10. Comments from Congressman James P. Moran, 8th District of Virginia

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: Theof"Wave the White

  11. Department of Energy Reply to Congressman James P. Moran | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny:Revised Finding of No53197E T A * S H I E L D * A L A R A *WIPP Recovery

  12. Department of Energy Reply to Congressman James P. Moran | Department of

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy China 2015 Business42.1Energy | Department ofofViolations |PlantsEnergy Docket No.

  13. The Dean's annual RepoRT 2014

    E-Print Network [OSTI]

    Loncar, Marko

    SEAS 46 DCE 61 FacultyTrends 65 Libraries 70 Sustainability 76 Financial 4 SpecialFeature 1 Letter 4 SEAS 46 DCE 61 FacultyTrends 65 Libraries 70 Sustainability 76 Financial 4 SpecialFeature 1 Letter #12 from the Dean 46 Division of Continuing Education (DCE) 61 Faculty Trends 65 FAS Libraries 70 FAS

  14. Oceanography Vol.22, No.264 By E r i c P. c h a s s i g N E t, h a r l E y E . h u r l B u rt, E . J o s E Ph M E t zg E r ,

    E-Print Network [OSTI]

    Oceanography Vol.22, No.264 By E r i c P. c h a s s i g N E t, h a r l E y E . h u r l B u rt, E . J o s E Ph M E t zg E r , o l E M a rt i N s M E d sta d, J a M E s a . c u M M i N g s , g E o r g E r . h a l l i w E l l , r a i N E r B l E c k , r E My B a r a i l l E , a l a N J . wa l lc r a f

  15. SEMI-ANNUAL REPORTS FOR FREEPORT McMoran - FE DKT. NO. 13-26-LNG - ORDER

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn'tOrigin ofEnergy atLLC - FE DKT. 10-160-LNG - ORDER 2913 | Department of EnergyLLC -

  16. Development and Characterization of a Multiplexed RT-PCR Species Specific Assay for Bovine and one for Porcine Foot-and-Mouth Disease Virus Rule-Out Supplemental Materials

    SciTech Connect (OSTI)

    Smith, S; Danganan, L; Tammero, L; Lenhoff, R; Naraghi-arani, P; Hindson, B

    2007-08-06T23:59:59.000Z

    Lawrence Livermore National Laboratory (LLNL), in collaboration with the Department of Homeland Security (DHS) and the United States Department of Agriculture (USDA), Animal and Plant Health Inspection Services (APHIS) has developed advanced rapid diagnostics that may be used within the National Animal Health Laboratory Network (NAHLN), the National Veterinary Services Laboratory (Ames, Iowa) and the Plum Island Animal Disease Center (PIADC). This effort has the potential to improve our nation's ability to discriminate between foreign animal diseases and those that are endemic using a single assay, thereby increasing our ability to protect animal populations of high economic importance in the United States. Under 2005 DHS funding we have developed multiplexed (MUX) nucleic-acid-based PCR assays that combine foot-and-mouth disease virus (FMDV) detection with rule-out tests for two other foreign animal diseases Vesicular Exanthema of Swine (VESV) and Swine Vesicular Disease (SVD) and four other domestic viral diseases Bovine Viral Diarrhea Virus (BVDV), Bovine Herpes Virus 1 (BHV-1 or Infectious Bovine Rhinotracheitus IBR), Bluetongue virus (BTV) and Parapox virus complex (which includes Bovine Papular Stomatitis Virus BPSV, Orf of sheep, and Pseudocowpox). Under 2006 funding we have developed a Multiplexed PCR [MUX] porcine assay for detection of FMDV with rule out tests for VESV and SVD foreign animal diseases in addition to one other domestic vesicular animal disease vesicular stomatitis virus (VSV) and one domestic animal disease of swine porcine reproductive and respiratory syndrome (PRRS). We have also developed a MUX bovine assay for detection of FMDV with rule out tests for the two bovine foreign animal diseases malignant catarrhal fever (MCF), rinderpest virus (RPV) and the domestic diseases vesicular stomatitis virus (VSV), bovine viral diarrhea virus (BVDV), infectious bovine rhinotracheitus virus (BHV-1), bluetongue virus (BTV), and the Parapox viruses which are of two bovine types bovine papular stomatitis virus (BPSV) and psuedocowpox (PCP). This document provides details of signature generation, evaluation, and testing, as well as the specific methods and materials used. A condensed summary of the development, testing and performance of the multiplexed assay panel was presented in a 126 page separate document, entitled 'Development and Characterization of A Multiplexed RT-PCR Species Specific Assay for Bovine and one for Porcine Foot-and-Mouth Disease Virus Rule-Out'. This supplemental document provides additional details of large amount of data collected for signature generation, evaluation, and testing, as well as the specific methods and materials used for all steps in the assay development and utilization processes. In contrast to last years effort, the development of the bovine and porcine panels is pending additional work to complete analytical characterization of FMDV, VESV, VSV, SVD, RPV and MCF. The signature screening process and final panel composition impacts this effort. The unique challenge presented this year was having strict predecessor limitations in completing characterization, where efforts at LLNL must preceed efforts at PIADC, such challenges were alleviated in the 2006 reporting by having characterization data from the interlaboratory comparison and at Plum Island under AgDDAP project. We will present an addendum at a later date with additional data on the characterization of the porcine and bovine multiplex assays when that data is available.

  17. T H E M AG A Z I N E O F T H E G E I S E L S C H O O L O F M E D I C I N E AT DA RT M O U T H 2 Dartmouth Medicine | dartmed.dartmouth.edu Fall 2012

    E-Print Network [OSTI]

    Myers, Lawrence C.

    T H E M AG A Z I N E O F T H E G E I S E L S C H O O L O F M E D I C I N E AT DA RT M O U T H effort 7 Rooting out a prion's sidekick 8 ... and more FEATURES L O O K I N G B A C K A N D M O V I N G F years at the Medical School. C E L E B R AT I N G G E N E R O S I T Y A N D P O S S I B I L I T Y 24

  18. Incorporating the Arts and Humanities in Palliative Medicine Education

    E-Print Network [OSTI]

    Marchand, Lucille R

    2006-01-01T23:59:59.000Z

    Humanities in Palliative Medicine Education 10. Marchand L.Whitecar P. Pain education in family medicine. (Monograph)of Teachers of Family Medicine, 2005. 16. Marchand L.Fast

  19. IMPROVED MISCIBLE NITROGEN FLOOD PERFORMANCE UTILIZING ADVANCED RESERVOIR CHARACTERIZATION AND HORIZONTAL LATERALS IN A CLASS I RESERVOIR - EAST BINGER (MARCHAND) UNIT

    SciTech Connect (OSTI)

    Joe Sinner

    2002-03-26T23:59:59.000Z

    The objective of this project is two-fold. It will demonstrate use of nitrogen as a widely available, cost-effective and environmentally superior injectant for miscible floods. It will also demonstrate the effectiveness of horizontal wellbores in reducing gas breakthrough and cycling. It is expected that the demonstration will lead to implementation of nitrogen injection projects in areas without readily available carbon dioxide sources. Technology transfer will occur throughout the project.

  20. Improved Miscible Nitrogen Flood Performance Utilizing Advanced Reservoir Characterization and Horizontal Laterals in a Class I Reservoir - East Binger (Marchand) Unit

    SciTech Connect (OSTI)

    Joe Sinner

    2004-06-30T23:59:59.000Z

    The DOE-sponsored project at the East Binger Unit is an investigation into the benefits of reservoir characterization and horizontal wells in this particular setting of geologic and recovery method. The geologic setting is a tight (average porosity of 7% and average permeability of less than 1 millidarcy) Pennsylvanian-age sandstone at about 10,000 feet, and the recovery method is a miscible nitrogen flood. The projected oil recovery of the East Binger Unit, prior to the initiation of this project, was about 25%. Gravity segregation of nitrogen and crude oil was believed to be the principal cause of the poor sweep efficiency, and it was envisioned that with horizontal producing wells in the lower portion of the reservoir and horizontal injection wells near the top, the process could be converted from a lateral displacement process to a vertical displacement/gravity assisted process. Through the characterization and field development work completed in Budget Periods 1 and 2, Binger Operations, LLC (BOL) has developed a different interpretation of the sweep problem as well as a different approach to improving recovery. The sweep problem is now believed to be one of an areal nature, due to a combination of natural and hydraulic fracturing. Vertical wells have provided a much better economic return than have the horizontal wells. The natural and hydraulic fracturing manifests itself as a direction of higher permeability, and the flood is being converted to a line drive flood aligned with this orientation. Consistent with this concept, horizontal wells have been drilled along the line of the fracture orientation, such that hydraulic fracturing leads to 'longitudinal' fractures, in line with the wellbore. As such, the hydraulically fractured horizontal wells are not significantly different than hydraulically fractured vertical wells - save for the potential for a much longer fracture face. This Topical Report contains data from new wells, plus new and updated production, pressure, and gas analysis data that was not included in the Topical Report provided at the end of Budget Period 1. The analysis and interpretation of these data are provided in the many technical reports submitted throughout this project.

  1. s.s. PACIFIC EXPLORER ~RT III -BELOW DECK ARRANGEMENTS

    E-Print Network [OSTI]

    ..................... .. .......... 24 Compressor Roam............................. 24 Storage and Freezer Compartments. ........... 29 Operational Problems......... .............. .... 31 Personnel

  2. AnnuAl RepoRt of ReseARch

    E-Print Network [OSTI]

    Lee, Dongwon

    and develop new, and renewable, sources of energy. Compounding the problem is the growing need to avert in this total was $375 million in funding from federal agencies, up from $372 million a year ago. Funding from greenhouse gas concentrations in the global atmosphere, thus slowing the rate of climate change. Energy

  3. College of Engineering ReseaRch RepoRt

    E-Print Network [OSTI]

    Provancher, William

    expenditures have more than doubled to $50.4M in 2008 (an average growth of 8% per year). Just as important, such as developing alternative energy sources (pages 6 and 9) and detecting Improvised Explosive Devices (page 8 recognized Technology Commercialization Office helps move early stage research results into the marketplace

  4. PROG RESS REPO RT FOR AEC CONT RACT AT(1

    Office of Scientific and Technical Information (OSTI)

    of amphibi ans in temporar y ponds. Ph.D. thesis Recent Colloqu im Present ations: i . Smith Colleg e, Northa mpton, Mass. - Connecticut College, New London, Conn. Univ. of Rhode...

  5. 6, 1270112728, 2006 3-D polarised RT and

    E-Print Network [OSTI]

    Boyer, Edmond

    and the water-cycle. Passive mm/sub-mm has some advantages compared to other space-borne cloud-ice remote in the hydrological cycle. Clouds can both absorb and reflect solar radiation (thereby cooling the surface) and absorb compared to other space-borne cloud-25 ice remote sensing techniques. Solar reflectance and thermal

  6. La matire grise RAPPoRt 2008-2010

    E-Print Network [OSTI]

    Shoubridge, Eric

    Personnel infirmier: Notre centre nvralgique 14 Initiatives du CECR: Ides brillantes 16 Sries de infirmiers, neuroscience Patricia O'Connor, IA, M. Sc. A., CHE1 Lucia Fabijan, B. Sc. Inf., M. Sc. A. 1 Directrice des soins infirmiers & infirmire en chef au Centre universitaire de sant McGill depuis octobre

  7. 20072008 Complete RepoRt Table of Contents LEHIGH UNIVERSITY

    E-Print Network [OSTI]

    Napier, Terrence

    . Balding '70 ++ W. Gregg Baldwin '74 Wendy and Gary Balter '11P Terry E. Banet '83 Jane Bannan '54 '05GP ++ Peter C. Bayer '60 '84P Theodore F. Bayer '70 Margaret Bearn William G. Beattie '59 '88P '93P ++ Blythe

  8. F'rt -COPY" NBSIR 81-2372 N

    E-Print Network [OSTI]

    Oak Ridge National Laboratory

    heater and hook-up to the water heating heat pump, the general applicability of the results is limited. #12;NBSIR 81-2372 DEVELOPMENT OF AN ENERGY TEST METHOD FOR A DEDICATED WATER-HEATING HEAT PUMP 4 C of this report is to present a test method for the water heating heat pump coupled with a 50-gallon electric

  9. Kraft Rt Kraft Electronics Inc | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere I Geothermal Pwer Plant Jump to: navigation, search GEOTHERMALTexas: EnergyKosovo: EnergyKrafla

  10. [2] O. Biran, S. Moran, and S. Zaks. A combinatorial characterization of the distributed 1solvable tasks. Journal of Algorithm 11, pages 420--440, 1990.

    E-Print Network [OSTI]

    Moran, Shlomo

    . Information and Computation, 105(1):132--158, July 1993. [6] A. Fekete. Asynchronous approximate agreement event e(i), associated with processor P i . This mapping should guarantee that if s is fair for i, then the run M dm (c; s) is fair for p i . By varying the way in which e(i) depends on P i , various

  11. WP AFB,WP AFB, DaytonDayton RT 2006RT 2006 1 Robust and Randomized Control Design

    E-Print Network [OSTI]

    Tempo, Roberto

    Flight Test Video and Computer Graphics Animation Randomized Algorithms: A Success Story Conclusions #12 This activity is supported by the Italian Ministry for Research within the National Project Study dynamic modeling - DC motor modeling - blade element theory - gain synthesis - control laws implementation

  12. Quantum State Protection and Transfer Using Superconducting Qubits

    E-Print Network [OSTI]

    Keane, Kyle Michael

    2012-01-01T23:59:59.000Z

    relaxation . . . . . . . . .1.5 Superconducting ? ux-biasedCorrection Algorithms for Superconducting Qubits, APS Marchand correction for superconducting qubits, Phys. Rev. A,

  13. a. Lngsamt & adiabatiskt reversibel, dvs en isentropisk process V1 = nRT1 / p1 = (m/M) RT1/p1 , massa m = 1 kg

    E-Print Network [OSTI]

    Zevenhoven, Ron

    Svar 1303: a. Långsamt & adiabatiskt reversibel, dvs en isentropisk process V1 = n·R·T1 / p1 = (m/M) ·R·T1/p1 , massa m = 1 kg H2 : M = 0.002 kg/mol; CO : M = 0.028 kg/mol; CO2 : M = 0.044 kg/mol p1 = z bar V1 = (R/M) · (300 + 50·a) / z m3 . t.ex. 30066 : p = 3 bar, gas = CO, T1 = 450 K V1 = 0.445 m3

  14. ISSN0249-0803ISRNINRIA/RT--7612--FR+ENG Vision, Perception and Multimedia Understanding

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    by reconstructing simultaneously buildings, trees and topographically complex grounds. A major contribution of our work is the original way of modeling buildings which guarantees a high generalization level while vision, 3D-geometry, shape representation, urban scenes, point data, energy minimization, Markov Random

  15. Stresa, Italy, 25-27 April 2007 0-LEVEL VACUUM PACKAGING RT PROCESS FOR MEMS RESONATORS

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    and hole clogging. It discusses mass production compatibility in terms of packaging stress during back]. The device is based on a suspended-gate resonating over a MOSFET channel which modulates the drain current. Suspended- Gate Drain Source Bulk contact a) 10 m Drain Source Suspended- Gate 6 m 1 m b) SiO2 c) 1 m Hole

  16. O. Bruguier D. Bosch R.T. Pidgeon D.I. Byrne L.B. Harris

    E-Print Network [OSTI]

    Demouchy, Sylvie

    Pinjarra Orogen after Myers et al. 1996) and represents an isolated Proterozoic basement inlier within

  17. Pediatric Respiratory Infectious Disease Analysis: UTM-RT versus Flocked Swab Nasal Collections

    E-Print Network [OSTI]

    2008-01-01T23:59:59.000Z

    the efficacy of the specimen collection methods. PredictingCA Background: The collection of anterior nasal washingsFlocked Swab Nasal Collections Paul Walsh 1 , Christina Lim

  18. 2012 EmploymEnt REpoRt RICE MBA Full TIME

    E-Print Network [OSTI]

    Senior Consultant Deutsche Bank Ryan Stohl Investment Banking Associate Energy Market Exchange Melanie Walker Investment Banking Associate Kalypso Mallory Engler Senior Consultant Sunny Sun Senior Consultant Magalhaes Global Accounts Manager Lloyd's Jeffrey Freedman Associate Marathon Oil Corporation Jesse Filipi

  19. Complete genome sequence of Syntrophobotulus glycolicus type strain (FlGlyRT)

    SciTech Connect (OSTI)

    Han, Cliff [Los Alamos National Laboratory (LANL); Mwirichia, Romano [Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya; Chertkov, Olga [Los Alamos National Laboratory (LANL); Held, Brittany [Los Alamos National Laboratory (LANL); Lapidus, Alla L. [U.S. Department of Energy, Joint Genome Institute; Nolan, Matt [U.S. Department of Energy, Joint Genome Institute; Lucas, Susan [U.S. Department of Energy, Joint Genome Institute; Hammon, Nancy [U.S. Department of Energy, Joint Genome Institute; Deshpande, Shweta [U.S. Department of Energy, Joint Genome Institute; Cheng, Jan-Fang [U.S. Department of Energy, Joint Genome Institute; Tapia, Roxanne [Los Alamos National Laboratory (LANL); Goodwin, Lynne A. [Los Alamos National Laboratory (LANL); Pitluck, Sam [U.S. Department of Energy, Joint Genome Institute; Huntemann, Marcel [U.S. Department of Energy, Joint Genome Institute; Liolios, Konstantinos [U.S. Department of Energy, Joint Genome Institute; Ivanova, N [U.S. Department of Energy, Joint Genome Institute; Pagani, Ioanna [U.S. Department of Energy, Joint Genome Institute; Mavromatis, K [U.S. Department of Energy, Joint Genome Institute; Ovchinnikova, Galina [U.S. Department of Energy, Joint Genome Institute; Pati, Amrita [U.S. Department of Energy, Joint Genome Institute; Chen, Amy [U.S. Department of Energy, Joint Genome Institute; Palaniappan, Krishna [U.S. Department of Energy, Joint Genome Institute; Land, Miriam L [ORNL; Hauser, Loren John [ORNL; Brambilla, Evelyne-Marie [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Rohde, Manfred [HZI - Helmholtz Centre for Infection Research, Braunschweig, Germany; Spring, Stefan [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Sikorski, Johannes [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Goker, Markus [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Woyke, Tanja [U.S. Department of Energy, Joint Genome Institute; Bristow, James [U.S. Department of Energy, Joint Genome Institute; Eisen, Jonathan [U.S. Department of Energy, Joint Genome Institute; Markowitz, Victor [U.S. Department of Energy, Joint Genome Institute; Hugenholtz, Philip [U.S. Department of Energy, Joint Genome Institute; Kyrpides, Nikos C [U.S. Department of Energy, Joint Genome Institute; Klenk, Hans-Peter [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Detter, J. Chris [U.S. Department of Energy, Joint Genome Institute

    2011-01-01T23:59:59.000Z

    Syntrophobotulus glycolicus Friedrich et al. 1996 is currently the only member of the genus Syntrophobotulus within the family Peptococcaceae. The species is of interest because of its isolated phylogenetic location in the genome-sequenced fraction of tree of life. When grown in pure culture with glyoxylate as carbon source the organism utilizes glyoxylate through fermentative oxidation, whereas, when grown in syntrophic co-culture with homoacetogenic or methanogenic bacteria, it is able to oxidize glycolate to carbon dioxide and hydrogen. No other organic or inorganic carbon source is utilized by S. glycolicus. The subdivision of the family Peptococcaceae into genera does not reflect the natural relationships, particularly re- garding the genera most closely related to Syntrophobotulus. Both Desulfotomaculum and Pelotomaculum are paraphyletic assemblages, and the taxonomic classification is in signifi- cant conflict with the 16S rRNA data. S. glycolicus is already the ninth member of the family Peptococcaceae with a completely sequenced and publicly available genome. The 3,406,739 bp long genome with its 3,370 protein-coding and 69 RNA genes is a part of the Genomic Encyclopedia of Bacteria and Archaea project.

  20. Te (R,t) Measurements using Electron Bernstein Wave Thermal Emission on NSTX

    SciTech Connect (OSTI)

    Diem, S J; Efthimion, P C; LeBlanc, B P; Carter, M; Caughman, J; Wilgen, J B; Harvey, R W; Preinhaelter, J; Urban, J

    2006-06-09T23:59:59.000Z

    The National Spherical Torus Experiment (NSTX) routinely studies overdense plasmas with ne of (15) X 1019 m-3 and total magnetic field of <0.6 T, so that the first several electron cyclotron harmonics are overdense. The electrostatic electron Bernstein wave (EBW) can propagate in overdense plasmas, exhibits strong absorption, and is thermally emitted at electron cyclotron harmonics. These properties allow thermal EBW emission to be used for local Te measurement. A significant upgrade to the previous NSTX EBW emission diagnostic to measure thermal EBW emission via the oblique B-X-O mode conversion process has been completed. The new EBW diagnostic consists of two remotely steerable, quad-ridged horn antennas, each of which is coupled to a dual channel radiometer. Fundamental (818 GHz) and second and third harmonic (1840 GHz) thermal EBW emission and polarization measurements can be obtained simultaneously.

  1. ISSN0249-0803ISRNINRIA/RT--443--FR+ENG December 2013

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    testbed dedicated to the security analysis of process control networks (SCADA) employed in industrial systems. The testbed is built on real hardware controllers and simulated physical processes which makes processes, we elaborated a methodology to infer a discrete model of the running controlled system through

  2. 554 VOLUME 14 NUMBER 6 JUNE 2013 nature immunology A rt i c l e s

    E-Print Network [OSTI]

    Gelb, Michael

    . 6Core Technology and Research Center, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan-affinity IgE receptor FcRI on mast cells with IgE and antigen initiates signals leading to the release and circulatory systems, often leading to life-threatening episodes. Environmentally induced alterations

  3. amplification rt-lamp system: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    receiver side over an AWGN channel with an energy Ulukus, Sennur 215 Amplification of seismic ground motion in the Tunis basin: Numerical BEM simulations vs experimental evidences...

  4. Tako imenovani Na?rt za pridigo iz rokopisne dobe sloven?ine

    E-Print Network [OSTI]

    Mikhailov, Nikolai

    1999-01-01T23:59:59.000Z

    ?mlicherweise ist aber die Akkusa- tivrektion gebraucht (wahrscheinlich als Analogie: Ia + Acc. 'f?r'). naIega Pron. poss. 1. P. PI. m. Gen. Sg. in -ega. goIpudy Subst. m. des i-Stammes (wie im CRR, SR, KR, SGR) pr?sentiert hier den U-Reflex des ursl. o, was ein... Zeichen der no- tranjgina oder der dolenjSCina sein kann. tu Adv. loc. mod. slow. tu 'hier' oder Pron. dem. N. Sg. n. mod. slow. to mit dem U-Ref lex. Iy k?nnte das Reflexivpronomen si sein. Semantisch m??te es aber als ie 'noch' in- terpretiert...

  5. a rt i c l e s nature medicine VOLUME 19 | NUMBER 4 | APRIL 2013 465

    E-Print Network [OSTI]

    that limit their clinical efficacy. IFA-based vaccines are water-in-oil emulsions of antigen in mineral oil with cancer (ClinicalTrials.gov). Here we used a preclinical model to better understand melanoma-specific CD8

  6. Climate Change: A Catastrophe in Slow Motion R.T. Pierrehumbert*

    E-Print Network [OSTI]

    Pierrehumbert, Raymond

    as unique or even unusually impressive. When oxygen-generating photosynthetic algae evolved between one--the animals and plants we know and love). And when plants colonized land half a billion years ago, they vastly generations and of the biosphere at large.2 It is against this backdrop that the foundation of international

  7. AnnuAl RepoRt Spend one year in our department of chemical engineering

    E-Print Network [OSTI]

    Behmer, Spencer T.

    unmistakingly familiar with its confluence of energy and passion, the measureable and immeasureable ways are highly empowered to provide cutting-edge resources and access to world-renowned faculty who haveRing sAt scoRes Fall 2013 (Avg.) enteRing gRe scoRes fAll 2013 (Avg.) enRollment stAtistics Note: 1 Total

  8. 2013AnnuAl RepoRt Office of the Vice President for Research

    E-Print Network [OSTI]

    Rock, Chris

    Vice President for Research 3 Introduction 4 Statistics 5 Economic Impact 7 Annual Institutional Annual Research Award and Expenditures by Sponsor Type 12 Institutional Federal R&D Funding Activity 13 for number of awards received. · We now have four National Academy members who are all focused on energy

  9. Preliminary ILAW Formulation Algorithm Description, 24590 LAW RPT-RT-04-0003, Rev. 1

    SciTech Connect (OSTI)

    Kruger, Albert A.; Kim, Dong-Sang; Vienna, John D.

    2013-12-03T23:59:59.000Z

    The U.S. Department of Energy (DOE), Office of River Protection (ORP), has contracted with Bechtel National, Inc. (BNI) to design, construct, and commission the Hanford Tank Waste Treatment and Immobilization Plant (WTP) at the Hanford Site (DOE 2000). This plant is designed to operate for 40 years and treat roughly 50 million gallons of mixed hazardous high-level waste (HLW) stored in 177 underground tanks at the Hanford Site. The process involves separating the hight-level and low-activity waste (LAW) fractions through filtration, leaching, Cs ion exchange, and precipitation. Each fraction will be separately vitrified into borosilicate waste glass. This report documents the initial algorithm for use by Hanford WTP in batching LAW and glass-forming chemicals (GFCs) in the LAW melter feed preparation vessel (MFPV). Algorithm inputs include the chemical analyses of the pretreated LAW in the concentrate receipt vessel (CRV), the volume of the MFPV heel, and the compositions of individual GFCs. In addition to these inputs, uncertainties in the LAW composition and processing parameters are included in the algorithm.

  10. LAL/RT 06-03 THE DESIGN AND PERFORMANCE OF CW AND PULSED POWER

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    for which couplers have, or are being, developed one finds VUV and X-ray free electron lasers (based on self-purity alumina (Al2O3) ceramic "windows" brazed onto the metallic guide (co-axial or WG) as a vacuum barrier requires delicate welding and brazing operations which must yield smooth, default free, RF surfaces

  11. 264 VOLUME 28 NUMBER 3 MARCH 2010 nature biotechnology A rt i c l e s

    E-Print Network [OSTI]

    Arnold, Frances H.

    high spatial resolution (mens. Functional with MRI sensors that were directly and rapidly responsive to neurochemicals involved in the brain's information processing4. The challenging process of developing sensors for next-generation neuroimaging could

  12. Department of recreational SportS AnnuAl RepoRt

    E-Print Network [OSTI]

    Escher, Christine

    of students and campus alike. oSU recreational Sports is recognized as a leader and source of best practices center. The study was originated in response to increasing concerns by the campus community related to overcrowding. Substantial and sustained growth has created a demand that currently exceeds our capacity

  13. RtS>-l-2437 Utilization of the Isotoplc Composition of

    E-Print Network [OSTI]

    irradiation. INIS-descriptors; FISSION YIELD; FISSION PRODUCT RELEASE; ISOTOPE COMPOSITION; KRYPTON ISOTOPES

  14. RT Level Power Analysis y Jianwen Zhu, Poonam Agrawal, Daniel D. Gajski

    E-Print Network [OSTI]

    California at Irvine, University of

    current and short circuit current respectively. The dominant factor is the first one due to the charging determine the previous states of all the internal circuit nodes, (3) the current data, which determine the current states of all the circuit nodes and in turn their switching activities. This is not practical

  15. RT Level Power Analysis y Jianwen Zhu, Poonam Agrawal, Daniel D. Gajski

    E-Print Network [OSTI]

    California at Irvine, University of

    dissipation in static CMOS circuit are dynamic switching, leakage current and short circuit current of all the internal circuit nodes, (3) the current data, which determine the current states of all. A lot of interesting work has been done on circuit and gate level [Na94]. While these tools can often

  16. National Aeronautics and Space Administration Student ReSeaRch RepoRt

    E-Print Network [OSTI]

    of our collaborative environment. About JPL the Jet propulsion Laboratory (JpL) is naSa's federally is the end-to-end implementation of unprecedented robotic space missions to study earth, the Solar System of the JPL campus. #12;1 Inside Welcome 3 Solar System Science 5 earth Science 8 astrophysics & Space Science

  17. AOMiN!STRAT!VE AF'FAtRS 204 -;IGS:RT HALL

    E-Print Network [OSTI]

    Slatton, Clint

    and Safety Act of 1970, Title 10 of the Atomic Energy Commission Code of Federal Regulations, and the Federal division From other untis of the University. Under Dr. Dunavant's leadership, Mr. Donald Price will head

  18. Quantifying a bystander response following microbeam irradiation using single-cell RT-PCR analyses

    E-Print Network [OSTI]

    -dependent kinase inhibitor CDKN1a (p21/Cip1/ WAF1) were quantified at the mRNA level in single normal human- rowed from a similar phenomenon previously reported from viral transfection experiments [14]. Early or of energy depositions in extracellular medium. Similar types of experiments have also demon- strated

  19. LIVE CARS FOR USE IN CATFISH INDUSTRY Donald C. ,r nland, Rob rt L. ..rill,

    E-Print Network [OSTI]

    to deep water, or set adjacent to a well head for holding fish. Haul trucks can be scheduled more easily to loading sit s or shift d to saf areas for holding. When us d along Ith a haul Sf ine, pulling accurately because fish in properly staked live cars do not escape and can be harvested before truck arrives

  20. arXiv:submit/0290259[math.RT]27Jul2011 THE CATEGORICAL WEIL REPRESENTATION

    E-Print Network [OSTI]

    Gurevich, Shamgar

    ))f(y), where G(B, ) is an appropriate Gauss sum normalization. 0.2. Canonical vector space. In [10, 11 of the Weil representation over a finite field k of odd characteristic: There exists a canonical system of intertwining operators between the Lagrangian models of the Heisenberg representation. This defines a canonical

  1. Diffuse large B-cell lymphoma: sub-classification by massive parallel quantitative RT-PCR

    E-Print Network [OSTI]

    Xue, Xuemin; Zeng, Naiyan; Gao, Zifen; Du, Ming-Qing

    2014-11-24T23:59:59.000Z

    The research in Du lab was supported by research grants (LLR10006 & LLR13006) from Leukaemia & Lymphoma Research, U.K.. XX was supported by a visiting fellowship from the China Scholarship Council, Ministry of Education, P.R. China. 2 ABSTRACT... , were retrieved and used for construction and validation of DLBCL classifier: the FF dataset by Lymphochip (http://llmpp.nih.gov/DLBCLpredictor/),3 the FF dataset (GSE10846: this was further split according to treatment with CHOP or R...

  2. APLUW 2009 BienniAL RePoRt 1 tABLe of Contents

    E-Print Network [OSTI]

    Washington at Seattle, University of

    and medical acoustics, and other areas of applied physics continues to be active and productive. At and development programs, improved research integration, and upgraded infrastructure--have been realized. We-sea experimentation remains in high demand, and invention is thriving: APL-UW has spun off eight companies in nearly

  3. V-190: ASUS RT-N66U Router AiCloud Security Bypass Security Issue |

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy China 2015of 2005UNSDepartmentFebruaryPhase|PotomacDepartmentRemoteVulnerability

  4. abdominopelviennes fixant le: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    sur l'organisation du march ? D'un point de vue marchand, le big data consiste transformer les traces big data est donc un processus de documentation. D'abord, nous...

  5. analysis le bois-electricite: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    sur l'organisation du march ? D'un point de vue marchand, le big data consiste transformer les traces big data est donc un processus de documentation. D'abord, nous...

  6. 22th International Meeting on org. geochem. The fate of organic matter in mangrove sediments

    E-Print Network [OSTI]

    Boyer, Edmond

    the behaviour of carbohydrates and lignin during early diagenesis (Marchand et al., 2003; 2004; 2005; in press). Here, we propose to present an integrated conceptual model for organic sedimentation and diagenesis

  7. EAOG Sville The fate of organic matter in mangrove sediments

    E-Print Network [OSTI]

    Boyer, Edmond

    during early diagenesis (Marchand et al., 2003; 2004; 2005; in press). Here, we propose to present an integrated conceptual model for organic sedimentation and diagenesis in French Guiana mangroves, taking

  8. LE BULLETIN DE L'EPI N 65 LA ROBOTIQUE PDAGOGIQUE ! LA ROBOTIQUE PDAGOGIQUE !

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    ? Daniel MARCHAND Je rentre justement de Mexico (Mexique) où s'est tenu le "Troisième Congrès International'automate "intelligent". #12;120 Daniel MARCHAND LE BULLETIN DE L'EPI Nombreux sont donc ceux qui pratiquent la R.P. sans/développement en R.P. soute- nue financièrement entre autre par l'APO QUEBEC), jusqu'à l'université où elle est

  9. Ecological Restoration for Community Benefit: People and Landscapes in Northern California, 1840-2010

    E-Print Network [OSTI]

    Diekmann, Lucy Ontario

    2011-01-01T23:59:59.000Z

    Evaluation of Stream Restoration. Restoration Ecology 3,Robertson. Privatizing stream restoration in the US. Moran, Sharon. Stream Restoration Projects: A Critical

  10. Universittsmedizin Gttingen Publikationen und Hochschulschriften 2010

    E-Print Network [OSTI]

    Gollisch, Tim

    -transduced, encephalitogenic T cells. J AUTOIMMUN, 35(2): 135-44. Buchbeiträge 1. Flügel A, Moran LB, Graeber M, Scheithauer BW

  11. nature structural & molecular biology VOLUME 19 NUMBER 6 JUNE 2012 633 a rt i c l e s

    E-Print Network [OSTI]

    Lim, Wendell

    biophysical characterization, the structural underpinnings of how voltage con- trols Ci-VSP function have of gating loop residue Glu411. Functional investigation of a battery of structure-based mutants evaluated

  12. ISSN0249-0803ISRNINRIA/RT--0349--FR+ENG INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN AUTOMATIQUE

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    anyone can access and configure a router, a sensor or a domotic system from any computer or personal

  13. A RT I C L E S 36 NATURE CELL BIOLOGY VOLUME 9 | NUMBER 1 | JANUARY 2007

    E-Print Network [OSTI]

    Cai, Long

    on neutrophil chemotaxis. To study PtdIns(3,4,5)P3 metabolism in living primary cells, we generated a novel a chemoattractant gradient. TheamoebaDictyosteliumdiscoideumandmammalianneutrophilsare the best-studied chemotactic in a shallow anterior-to-posterior gradient that approximates receptor occupancy11 . Instead, the second

  14. Magnetic properties of RT2Zn20; R = rare earth, T = Fe, Co, Ru, Os and Ir

    SciTech Connect (OSTI)

    Jia, Shuang

    2008-12-15T23:59:59.000Z

    It is well known that rare earth intermetallic compounds have versatile, magnetic properties associated with the 4f electrons: a local moment associated with the Hund's rule ground state is formed in general, but a strongly correlated, hybridized state may also appear for specific 4f electronic configuration (eg. for rare earth elements such as Ce or Yb). On the other hand, the conduction electrons in rare earth intermetallic compounds, certainly ones associated with non hybridizing rare earths, usually manifest non-magnetic behavior and can be treated as a normal, non-interacted Fermi liquid, except for some 3d-transition metal rich binary or ternary systems which often manifest strong, itinerant, d electron dominant magnetic behavior. Of particular interest are examples in which the band filling of the conduction electrons puts the system in the vicinity of a Stoner transition: such systems, characterized as nearly or weakly ferromagnet, manifest strongly correlated electronic properties [Moriya, 1985]. For rare earth intermetallic compounds, such systems provide an additional versatility and allow for the study of the behaviors of local moments and hybridized moments which are associated with 4f electron in a correlated conduction electron background.

  15. 2012 RepoRt IllInoIs natuRal hIstoRy suRvey

    E-Print Network [OSTI]

    Bashir, Rashid

    research institute From the Executive Director 3 Financial Overview 5 Issues 6 Advancing Clean Energy as an example for the nation and the world. Editors: Susan Braxton, Libby Johnston, Lisa Sheppard, Steve Wald around the world. Among a myriad of other research and ser- vice projects, we provide data and expertise

  16. IUT de Villetaneuse, Universit Paris 13, Sorbonne Paris Cit Licence Pro R&T ASUR Travaux pratiques de cryptographie

    E-Print Network [OSTI]

    Andr, tienne

    pratiques de cryptographie Cryptographie : GPG tienne Andr Version du sujet : 1er dcembre 2014 Ce TP s avec LibreOffice et export en PDF. Nom du fichier : crypto-TP-gpg-nom-prenom.pdf Adresse lectronique : Etienne.Andre(arobase)univ-paris13.fr Objet du courriel : TP crypto GPG : Le compte

  17. 2009 AnnuAl RepoRt NOW" I'm constantly amazed now at how much of development

    E-Print Network [OSTI]

    Sabatini, David M.

    as SH3D19 (stained blue). credits director and editor Matt Fearer associate editor Nicole Giese engulf exterior molecules, creating membrane-bound bubbles that shuttle the molecules into the cell

  18. Observation of a new high-? and high-density state of a magnetospheric plasma in RT-1

    SciTech Connect (OSTI)

    Saitoh, H.; Yano, Y.; Yoshida, Z.; Nishiura, M.; Morikawa, J.; Kawazura, Y.; Nogami, T.; Yamasaki, M. [Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561 (Japan)

    2014-08-15T23:59:59.000Z

    A new high-? and high-density state is reported for a plasma confined in a laboratory magnetosphere. In order to expand the parameter regime of an electron cyclotron resonance heating experiment, the 8.2?GHz microwave power of the Ring Trap 1 device has been upgraded with the installation of a new waveguide system. The rated input power launched from a klystron was increased from 25 to 50?kW, which enabled the more stable formation of a hot-electron high-? plasma. The diamagnetic signal (the averaged value of four magnetic loops signals) of a plasma reached 5.2 mWb. According to a two-dimensional Grad-Shafranov analysis, the corresponding local ? value is close to 100%.

  19. Extraction of RNA-Trizol RNA extraction from M. tuberculosis (Mahenthiralingam 1998) is useful for RT-PCR

    E-Print Network [OSTI]

    Extraction of RNA-Trizol RNA extraction from M. tuberculosis (Mahenthiralingam 1998) is useful of isopropanol. 10. Precipitate overnight at 20C. Prepare cold 70% ethanol with DEPC treated water. Centrifuge DNA is present, repeat Trizol extraction. #12;

  20. Weakcontrast R/T coefficients in weakly anisotropic media: Pwave 9iFODY#9DYU\\XN

    E-Print Network [OSTI]

    Cerveny, Vlastislav

    of transversely isotropic halfspaces. Zillmer, Gajewski & Kashtan (1998) derived PP reflection coefficient

  1. 710 VOLUME 20 NUMBER 6 JUNE 2013 nature structural & molecular biology a rt i c l e s

    E-Print Network [OSTI]

    Bedwell, David M.

    and eukaryotic release factor 3 (eRF3), the central NMD factor up-frameshift 1 (UPF1) instead binds to eRF3 the SMG1UPF1release factor (SURF) complex25,26. The subsequent interaction of UPF2 and UPF3B with UPF1 phosphorylation of UPF1 (refs. 25,2729). UPF1 phosphor- ylation is essential for mammalian NMD and is believed

  2. 1214 VOLUME 20 NUMBER 10 OCTOBER 2013 nature structural & molecular biology a rt i c l e s

    E-Print Network [OSTI]

    Bedwell, David M.

    the mechanistically related NMD pathway, involves the UPF1 RNA helicase4,12. An SBS bound by STAU1 and/or its paralog that the complex has acquired UPF1. STAU1 and STAU2 bind UPF1 directly during SMD13, as does the EJC constituent UPF2 (refs. 14,15) or, in some cases, the EJC constituent UPF3X (also called UPF3B)1,16,17 during NMD

  3. 702 VOLUME 20 NUMBER 6 JUNE 2013 nature structural & molecular biology a rt i c l e s

    E-Print Network [OSTI]

    Bedwell, David M.

    is initiated by the assembly of NMD fac- tors on target mRNAs. The core NMD factors are the proteins UPF1, UPF2 and UPF3, which are conserved in eukaryotes2,8. Translation termination at a PTC induces the assembly of UPF1, a superfamily 1 ATP-dependent RNA helicase, with the terminating ribosome through an interaction

  4. SU-E-T-99: Design and Development of Isocenter Parameter System for CT Simulation Laser Based On DICOM RT

    SciTech Connect (OSTI)

    Luo, G [Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China (China)

    2014-06-01T23:59:59.000Z

    Purpose: In order to receive DICOM files from treatment planning system and generate patient isocenter positioning parameter file for CT laser system automatically, this paper presents a method for communication with treatment planning system and calculation of isocenter parameter for each radiation field. Methods: Coordinate transformation and laser positioning file formats were analyzed, isocenter parameter was calculated via data from DICOM CT Data and DICOM RTPLAN file. An in-house software-DicomGenie was developed based on the object-oriented program platform-Qt with DCMTK SDK (Germany OFFIS company DICOM SDK) . DicomGenie was tested for accuracy using Philips CT simulation plan system (Tumor LOC, Philips) and A2J CT positioning laser system (Thorigny Sur Marne, France). Results: DicomGenie successfully established DICOM communication between treatment planning system, DICOM files were received by DicomGenie and patient laser isocenter information was generated accurately. Patient laser parameter data files can be used for for CT laser system directly. Conclusion: In-house software DicomGenie received and extracted DICOM data, isocenter laser positioning data files were created by DicomGenie and can be use for A2J laser positioning system.

  5. NATURE STRUCTURAL & MOLECULAR BIOLOGY VOLUME 16 NUMBER 12 DECEMBER 2009 1267 A RT I C L E S

    E-Print Network [OSTI]

    Chou, James

    of BM2 is also a coiled-coil tetramer, and its unusually large electrostatic dipole moment suggests-coil tetramer with a packing angle of about -37 (Fig. 1a). The tetramer has a well 1Department of Biological

  6. DOE/SC-ARM-10-032 ARM Climate Research Facility AnnuAl RepoRt - 2010

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadapInactiveVisitingContract Management Fermi SitePARTOffice ofHale Plan24,7,INL is aSC810-032 ARM

  7. DOE/SC-ARM-12-023 ARM Climate Research Facility AnnuAl RepoRt - 2012

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadapInactiveVisitingContract Management Fermi SitePARTOffice ofHale Plan24,7,INL is6 ARM20

  8. Plus: Reunion 2014 Introducing our new Provost TRINITY ALUMNI MAGAZINE spRING 2014

    E-Print Network [OSTI]

    Sokolowski, Marla

    Plus: Reunion 2014 Introducing our new Provost TRINITY ALUMNI MAGAZINE spRING 2014 trinity remembering the great war #12;Dr. Michael ratcliffe Interim Provost it is spring (at last!) at Trinity. Just that Mayo Moran, Dean of the Faculty of Law, will become Trinity's 15th Provost. Dean Moran and I

  9. @o/oohyh#v' 's +rys#'f#vv+vt p'#...'y +#...p#...r+ s'... h v#rt...h#rq Qr#y'x

    E-Print Network [OSTI]

    Skogestad, Sigurd

    for optimisation purposes. It has been reported that a typical energy saving of 30% is achievable with a Petlyuk to maintain if disturbances and model uncertainty are present. Selfoptimising control is an approach to solve and model uncertainties compared to any open loop model based optimisation methods. The application of selfoptimising

  10. Transactions, SMiRT 21, 6-11 November, 2011, New Delhi, India Div-VII: Paper ID# 804 DEVELOPMENT OF PARTIAL SAFETY FACTORS FOR ACCIDENTAL

    E-Print Network [OSTI]

    Bhattacharya, Baidurya

    were designed using the French RCC-G code. The raft of the PWHR at Tarapur was designed using the ASME code and checked against RCC-G [1]. There is yet no formal Indian design standard for containment structures. In 2007, the Atomic Energy Regulatory Board (AERB) of India released the CSE-3 codes [3] which

  11. ReGional ColleGe Review 2010 Final RepoRt CaRlton tRail ReGional ColleGe

    E-Print Network [OSTI]

    Saskatchewan, University of

    Members Aaron Behiel Humboldt Ron Bessey Watson Andrew Burgess Director of Finance Maureen Doetzel-Cross Watrous Amy Yeager Director of Programs Community Participants Sharon Armstrong Resident of Wynyard Leigh. Demetrius Wasylyniuk St. Peter's College Board Carol Weiman Career and Employment Services Consultations

  12. Analysis of genes regulated by the peroxide response regulator PerR in Borrelia burgdorferi using real-time RT-PCR

    E-Print Network [OSTI]

    Swingle, Kristen Lynn

    2002-01-01T23:59:59.000Z

    upstream of sodA in B. burgdorjeri. However, sodA is co- transcribed with secA in B. burgdarferi (25), and upstream of secA there is a putative PerR binding domain with homology at 10 of the 19 bases (Fig. I). For this reason, we want to determine... of the secA gene, which is co-transcribed with sodA (25). We have observed an increase in superoxide dismutase activity in JS167 compared to the Lab parental strain (Fig. 8), implying that PerR regulates the expression of sodA or regulates the expression...

  13. FRAMES-2.0 Software System: Linking to the Groundwater Modeling System (GMS) RT3D and MT3DMS Models

    SciTech Connect (OSTI)

    Whelan, Gene; Castleton, Karl J.; Pelton, Mitch A.

    2007-08-08T23:59:59.000Z

    Linkages to the Groundwater Modeling System have been developed at Pacific Northwest National Laboratory to enable the Nuclear Regulatory Commission (NRC) to more realistically assess the risk to the public of radioactive contaminants at NRC-licensed sites. Common software tools presently in use are limited in that they cannot assess contaminant migration through complex natural environments. The purpose of this initiative is to provide NRC with a licensing safety-analysis tool with sufficient power, flexibility, and utility that it can serve as the primary software platform for analyzing the hazards associated with licensing actions at those complex sites at which the traditional tools are inappropriate. As a tool designed to realistically approximate prospective doses to the public, this initiative addresses NRCs safety-performance goal by confirming that licensing actions do not result in undue risk to the public.

  14. Don't break the pipeline: Ensuring a workforce for the burning plasma era G.M. Olynyk, Z.S. Hartwig, and R.T. Mumgaard

    E-Print Network [OSTI]

    Don't break the pipeline: Ensuring a workforce for the burning plasma era G.M. Olynyk, Z.S. Hartwig plant ("Pilot"), the next- step fusion energy device will be designed, built, and op- erated the crucial distinction between facility construction and workforce development. Unlike building facilities

  15. 2010-2011 ANNUAl REPoRt O F Y E S H I V A U N I V E R S I T Y

    E-Print Network [OSTI]

    Kenny, Paraic

    , Nigeria, Rwanda, South Africa and Uganda. Each year, Einstein faculty members and some 50 medical, Einstein's Jack and Pearl Resnick Campus pulses with energy. Our research centers are where our world

  16. RT in situ PCR detection of MART-1 and TRP-2 mRNA in formalin-fixed, paraffin-embedded tissues of melanoma and nevi.

    E-Print Network [OSTI]

    Itakura, Eijun; Huang, Rong-Rong; Wen, Duan-Ren; Paul, Eberhard; Wnsch, Peter H; Cochran, Alistair J

    2008-01-01T23:59:59.000Z

    Cochran AJ. Detection of tyrosinase mRNA in formalin-fixed,PM, Hearing VJ. A second tyrosinase- related protein, TRP-2,mRNA isoforms of the tyrosinase-related protein-2/DOPAchrome

  17. 1.1 Basic ideas r(t) is the position of a particle; r = |r| is the distance to the origin.

    E-Print Network [OSTI]

    Rucklidge, Alastair

    speed of the particle is v = R. (11) #12;Chapter 2 Dynamics: Newton's laws of motion and gravitation 2 interacting though equal and opposite forces is constant. 3 #12;4 2.2 Newton's Law of Gravitation 2.2 Newton's Law of Gravitation Two particles of masses M and m a distance r apart exert a mutually attractive

  18. 456 VOLUME 18 | NUMBER 3 | MARCH 2012 nature medicine t e c h n i ca l r e p o rt s

    E-Print Network [OSTI]

    Ritchie, Robert

    successfully infused for the treatment of degenerative heart or neu- ronal diseases or for injury repair46. However, systemic infusions of MSCs in vivo do not promote an osteogenic response in bone because of the inability of MSCs to home to the bone surface unless they have been genetically modified710 or are infused

  19. 1350 VOLUME 46 | NUMBER 12 | DECEMBER 2014 Nature GeNetics t e c h n i c a l r e p o rt s

    E-Print Network [OSTI]

    Kaski, Samuel

    genome;however,callingvariantsintheremaining10%of thegenome. Accurate determination of an individual's genome is essential for understanding both human hereditary disease and cancer. Advances in genome sequencing have made it possible, at relatively low cost

  20. arXiv:math/0401317v2[math.RT]11Feb2004 Affine braids, Markov traces and the category O

    E-Print Network [OSTI]

    Ram, Arun

    alge- bras, cyclotomic Hecke algebras, affine BMW algebras, cyclotomic BMW algebras, Markov traces) We define the affine BMW algebra (Birman-Murakami-Wenzl) and show that it has a representation theory

  1. Fractal Strings and Multifractal Zeta Functions

    E-Print Network [OSTI]

    Lapidus, Michel L.; Lvy-Vhel, Jacques; Rock, John A.

    2009-01-01T23:59:59.000Z

    decompositions of Moran fractals. Adv. Math. 92, 196236 (Probab. 12, 8. Falconer, K. : Fractal GeometryMathematicalB.M. , Lapidus, M.L. : Random fractal strings: their zeta

  2. Field results of the polymer flooding pilot project in eastern Kansas

    SciTech Connect (OSTI)

    McCauley, R.T.

    1983-01-01T23:59:59.000Z

    The Moran field in Allen County, Kans., has been producing since the early 1900s. Flooding became the principal means of production in this pool in 1957. Inexco purchased the Moran field in 1968. In June of 1975, Inexco Oil Co. initiated a Polymer Pilot Project on the Kreiger Lease in the Moran field. In March of 1977, this project was expanded from it's original 20 acres to a 126-acre project. This case history addresses the financial and technical success of this project and is considered significant in terms of the future of enhanced recovery projects in this type of reservoir. Inexco has demonstrated the feasibility and successful recovery of additional oil from the Moran Pool by means of the addition of polymer to the existing waterflood. This work describes the operations and interpretation of the results.

  3. The Causes of Trade Globalization: A Political-Economy and World-Systems Approach

    E-Print Network [OSTI]

    Kwon, Roy

    2011-01-01T23:59:59.000Z

    purchasing power parities (PPP) which estimate the price forMoran (2009:60-63) show that PPP conversions are unrealisticlong periods of time unless PPP weights are recalculated for

  4. A Simple Self-Maintaining Metabolic System: Robustness, Autocatalysis, Bistability

    E-Print Network [OSTI]

    Piedrafita1 , Francisco Montero1 , Federico Moran1 , Maria Luz Cardenas2 , Athel Cornish-Bowden2 * 1-maintaining mode, the entire network being necessary to maintain the two catalysts. Citation: Piedrafita G, Montero

  5. 304 IEEE TRANSACTIONS ON SEMICONDUCTOR MANUFACTURING, VOL. 4, NO. 4, NOVEMBER 1991 A Process Control Methodology Applied to

    E-Print Network [OSTI]

    del Alamo, Jess A.

    304 IEEE TRANSACTIONS ON SEMICONDUCTOR MANUFACTURING, VOL. 4, NO. 4, NOVEMBER 1991 A Process.Moran was with the Massachusetts Institute of Technology. Cam- bridge, MA 02139. He is now with McKinsey and Company, Inc., San

  6. CONTAMINANT MONITORING AND RESEARCH SANFRANCISCOESTUARYINSTITUTE

    E-Print Network [OSTI]

    District Brake Pad Steering Committee Rodger Dabish, TMD Friction, Inc. Michael Endicott, for the Sierra Club Tim Merkel, Ph.D., for friction material manufacturers Kelly Moran, Ph.D., for BASMAA Jim.................................................................................. 12 3.5 Dry Deposition

  7. What are matching gifts? Many corporations match their employees' charitable contributions. Your support for The

    E-Print Network [OSTI]

    Azevedo, Ricardo

    Mobil FAMM LLC Firestone/Bridgestone Tire First Data Corporation FMC Foundation Freeport McMoran, Inc Co. Georgia Gulf Corporation Goodyear Corp. Graybar Electric Co. Great Lakes Carbon Corp. Grinnell

  8. 2008 Year in Review 1 2008 Year in Review

    E-Print Network [OSTI]

    Hickman, Mark

    2008 Year in Review 1 2008 Year in Review The Science of Communication Disorders Departmental Research Committee. #12;2 2008 Year in Review Billinghurst, M., Moran, C., Gostomski, P., Basu, A

  9. Sulphate record from a northeast Greenland ice core over the last 1200 years based on continuous flow analysis

    E-Print Network [OSTI]

    Fischer, Hubertus

    distribution of heat, salt, and moisture, potentially driving climatic change on regional to global scales; Moran et al., 2006). In 2004, the first Integrated Ocean Drilling Program expedition to the Lomonosov

  10. NORTH CAROLINA STATE UNIVERSITY SPRING COMMENCEMENT

    E-Print Network [OSTI]

    Velev, Orlin D.

    Remarks by Graduating Senior Esmeralda Luna-Ramos Awarding of Diplomas 8:00 PM Closing Faculty and Staff Maryia Sergeyeuna Krotava Matthew Moran Lapaire * Rosemary Khuu Le Adam Barton Leedy Esmeralda Luna

  11. REVISION OF PALEOTROPICAL MEGALASTRUM

    E-Print Network [OSTI]

    published in this series are treatments of the 18 species of Megalas- trum in Brazil, Paraguay, and Uruguay are coarse, whitish, septate, acicular, and antrorsely or patently strigose (Smith & Moran, 1987). After

  12. Harem

    E-Print Network [OSTI]

    Roth, Silke

    2012-01-01T23:59:59.000Z

    American Research Center in Egypt 11, pp. 98 - 101. Moran,El-Bahari. Vol. 2. Memoir of the Egypt Exploration Fund 30.London: The Egypt Exploration Fund. Nord, Del 1981 The Term

  13. This Week In Engineering Around the COE

    E-Print Network [OSTI]

    a foundational understanding of the automotive F&I industry. 2. Competitive Analysis work with field personnel by automotive legend Jim Moran, JM Family Enterprises, Inc. (www.jmfamily.com) is a diversified automotive

  14. Temporal variation of residential pesticide use and comparison of two survey platforms: a longitudinal study among households with young children in Northern California

    E-Print Network [OSTI]

    Wu, Xiangmei (May); Bennett, Deborah H; Ritz, Beate; Tancredi, Daniel J; Hertz-Picciotto, Irva

    2013-01-01T23:59:59.000Z

    2005, 113:123136. Vogt R, Bennett D, Cassady D, Frost J,Health 2012, 11:83. Wu XM, Bennett DH, Ritz B, Cassady DL,48:31093119. Moran RE, Bennett DH, Tancredi D, Wu XM, Ritz

  15. air resources board: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Institute, Vanessa Escobar of the Texas Water Development Board, and Ernest Moran of the San Antonio River Author- ity calculate load duration curves... Jensen, Ric 2008-01-01 133...

  16. Calibration of Scanning Electron Microscope using a multi-image non-linear minimization process

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    Calibration of Scanning Electron Microscope using a multi-image non-linear minimization process Le Cui1 and Eric Marchand2 Abstract-- In this paper, a novel approach of SEM calibration based on non-linear minimization process is presented. The SEM calibration for the intrinsic parameters are achieved

  17. 2013 PLASTIC SURGERY VISITING PROFESSOR

    E-Print Network [OSTI]

    Shoubridge, Eric

    2013 PLASTIC SURGERY VISITING PROFESSOR Dr. Mutaz B. Habal June 6, 2013 McGill University Division of Plastic Surgery 2013 PLASTIC SURGERY VISITING PROFESSOR Special thanks to our sponsors: Representative: Katherine Marchand Canadian Association of Plastic Surgeons Educational Foundation Division of Plastic

  18. 2005 International Truck & Bus Safety & Security Symposium 447 SAFETY AND SECURITY TECHNOLOGIES OF IMPORTANCE TO

    E-Print Network [OSTI]

    , Michigan; Ventura County Transportation Commission (VCTC) in Ventura County, California; and Tri solution. According to Dan Marchand of TriMet, Portland, Oregon, "technology makes it possible to deliver trips. TriMet, on the other hand, coordinates a very large, fixed route, multi-modal transit program

  19. Controlling an uninstrumented manipulator by visual servoing

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    Controlling an uninstrumented manipulator by visual servoing Eric Marchand, Francois Chaumette and this manipulator is usually open-loop controlled. In order to get a more efficient control interface, we propose, measurements of the manipulator motion with proprioceptive sensors is not required to precisely control the end

  20. ASYMPTOTIC SHAPE FOR THE CONTACT PROCESS IN RANDOM ENVIRONMENT

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    ASYMPTOTIC SHAPE FOR THE CONTACT PROCESS IN RANDOM ENVIRONMENT OLIVIER GARET AND REGINE MARCHAND in stationary random environment. These theorems gen- eralize known results for the classical contact process environment, when the contact process survives, the set Ht/t almost surely converges to a compact set

  1. AMAST '96, July 1-5, 1996, Munich, Germany Formal Veri cation of Signal Programs

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    to a Power Transformer Station Controller? Michel Le Borgne, Herve Marchand, Eric Rutten IRISA / INRIA cation of the automatic circuit breaking control system of an electric power transformer station is double:protecting the components of the transformer itself, and minimizing the defect in the distribution

  2. Compression of redundancy free trellis stages in Turbo-Decoder

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Compression of redundancy free trellis stages in Turbo-Decoder E. Boutillon, J. Sánchez-Rojas and C. Marchand For turbo code with coding rate close to one, the high puncturing rate induces long sequences. The computation is reduced accordingly. Introduction: Turbo codes with coding rate close to one are specified

  3. Texas camelid health and management survey

    E-Print Network [OSTI]

    Jacklitsch, Brenda Louise

    2009-06-02T23:59:59.000Z

    2.1 Camelid Background Llamas and alpacas have gained much popularity in recent years. This may be occurring as more people from urban areas decide to move to rural areas for the purpose of having a more laid back lifestyle. Approximately 100... to lack power, so the use of multiple tests was needed to look for patterns of clustering. ArcGIS Spatial Tools4 was used to run the spatial analysis tests. Moran?s autocorrelation was used to measure spatial dependence of disease prevalence. Getis...

  4. Quarter Color Section Experimental Treatment Genes Measured Observations Fall07 Green AA Heat Stress 2h 37C Hsp70-3, Derepression Hsp70-3 in hac1 at RT

    E-Print Network [OSTI]

    Carrington, Emily

    Quarter Color Section Experimental Treatment Genes Measured Observations Fall07 Green AA Heat Blue AA Cold Stress 3h 4C Fall07 Blue AB Heat Stress 1h, 2h 37C Fall07 Blue AC Cold Stress 20' 4C AA Light/Dark/Cold Cor 15a Not sufficient samples to determine Win08 Green AB Heat Stress 1h 37C Hsp

  5. 40 H A S T I N G S C E N T E R R E P O RT May-June 2008 resident Bush's compromise policy on human

    E-Print Network [OSTI]

    Streiffer, Robert

    -human chimeras. These problems provide ethical reasons not to perform several kinds of important research stem cell lines reveals several problems, providing ethical as well as scientific reasons to overturn derived reveals a parallel ethical argument for expanding feder- al funding. In the course of establish

  6. copyrisht@ree2bythen-""i"",,R3il:'J[$H#"",i*tTy"t"*r1"'J?rt;""mission orthecopyrightowner. Toward Orthogonal Self-Assembly of Redox Active

    E-Print Network [OSTI]

    Prentiss, Mara

    Orthogonal Self-Assembly of Redox Active Molecules on Pt and Au: Selective Reaction of Disulfide with Au.; Uphaus,R. A. Microchem.J.1990,42, 44, and referencestherein on viologen monolayer electrochemistry. (5

  7. T E C H N I C A L R E P O RT S I N C O M P U T E R S C I E N C E Technische Universitt Dortmund

    E-Print Network [OSTI]

    Morik, Katharina

    energy be saved by using an additional GPGPU-equipped graphics card to accelerate general purpose Reducing the Energy Consumption of Embedded Systems by Integrating General Purpose GPUs Constantin Timm Gelenberg, Peter Marwedel,Frank Weichert: Reducing the Energy Consumption of Embedded Systems by Integrating

  8. This paper appeared in the Proceedings of the 12th IEEE International Symposium on Distributed Simulation and Real Time Applications (DS-RT'08), Vancouver, British Columbia, Canada, Oct. 2008.

    E-Print Network [OSTI]

    Qin, Xiao

    serious. Growing evidence shows that among various hardware resources in a data center, storage systems (e in parallel disk systems has strong impacts on the cost of backup power-generation and cooling equipment and cooling. Although a variety of parallel disk systems were developed to achieve high performance and energy

  9. Supplemental Data. Graeber et al. (2011). A Guideline to Family-wide Comparative State-of-the-art qRT-PCR Analysis Exemplified with a Brassicaceae Cross-species

    E-Print Network [OSTI]

    Leubner, Gerhard

    Supplemental Data. Graeber et al. (2011). A Guideline to Family-wide Comparative State-of-the-art q Methods #12;Supplemental Data. Graeber et al. Plant Cell. (2011): PLANTCELL/2011/084103 2 Supplemental. Graeber et al. Plant Cell. (2011): PLANTCELL/2011/084103 3 Supplemental Table 1. Sequence similarities

  10. T E C H N I C A L R E P O RT S I N C O M P U T E R S C I E N C E Technische Universitt Dortmund

    E-Print Network [OSTI]

    Morik, Katharina

    cost efficient systems can be produced. Other properties of the system, like energy- efficiency, can fault is a violation of the premise that a read of a memory cell always returns exactly the value

  11. Virginia Tech Comprehensive Power-based Fuel Consumption Model: Model Development and Testing

    E-Print Network [OSTI]

    Rakha, Hesham A.

    The transportation sector consumes approximately 30% of the total energy in the United States, which is mostlyVirginia Tech Comprehensive Power-based Fuel Consumption Model: Model Development and Testing, Moran, Saerens, and Van den Bulck 2 ABSTRACT Existing fuel consumption and emission models suffer from

  12. Salle Tanna Shulich Hall 527, rue Sherbrooke ouest, Montral, QC

    E-Print Network [OSTI]

    Kambhampati, Patanjali

    / coordinator Quintette no1 / Quintet No.1 Victor Ewald I. Moderato II. Adagio, non troppo lento, Allegro vivace III. Allegro moderato (1860-1935) Chris Moran, David Fhima, trompettes / trumpet; Anna Pierson, cor Bach I. Andante con moto - Allegro con brio II. Andantino - Allegro molto Presto III. Molto Vivace

  13. [Mic89] R. Michel. A categorical approach to distributed systems expressibility and knowledge. In Proc. 8th ACM Symp. on Principles of Distributed Computing, pages 129--143, August 1989.

    E-Print Network [OSTI]

    Moran, Shlomo

    . Taubenfeld. Leader election in the presence of n \\Gamma 1 initial failures. Information Processing Letters. Taubenfeld, S. Katz, and S. Moran. Impossibility results in the presence of multiple faulty processes. In 9th, May 1990. PhD Thesis. [VA86] P. M. B. Vitanyi and B. Awerbuch. Atomic shared register access

  14. Submitted by In partial fulfillment of the requirements for the degree of

    E-Print Network [OSTI]

    MacDonald, Lee

    THESIS Submitted by In partial fulfillment of the requirements for the degree of Colorado State the variogram and Moran's I analyses indicate that the first hypothesis may be supported. Variogram gamma values the winter season. iii #12;Results of the variogram analyses for the multiple scale snow depth datasets do

  15. eScholarship provides open access, scholarly publishing services to the University of California and delivers a dynamic

    E-Print Network [OSTI]

    Cavanaugh, Kyle

    Peer Reviewed Title: Synchrony in dynamics of giant kelp forests is driven by both local recruitment://www.escholarship.org/uc/item/7vw6c5gg Keywords: giant kelp, Landsat, Macrocystis pyrifera, Moran effect, population dynamics kelp (Macrocystis pyrifera) canopy biomass to examine population synchrony in southern California kelp

  16. Computer Science Department Technion, IIT Algorithms in Computational Biology 236522

    E-Print Network [OSTI]

    Beimel, Amos

    Computer Science Department Technion, IIT Algorithms in Computational Biology 236522 Moed A Exam Spring 2007, 24.9.07 Lecturer: Shlomo Moran TA: Ilan Gronau - Exam Duraion: 3 hours - The Exam has 3 structure can be used to answer the desired queries. 2. (23 pts) Denote by Si the sequence S after deletion

  17. I/I ratios and halogen concentrations in pore waters of the Hydrate Ridge: Relevance for the origin of gas hydrates in ODP Leg 204

    E-Print Network [OSTI]

    Fehn, Udo

    in fluids associated with hydrocarbons, such as oil field brines (Moran et al., 1995) or coal-bed methane association of iodine with methane allows the identification of the organic source material responsible for iodine and methane in gas hydrates. In all cores, iodine concentrations were found to increase strongly

  18. Postdoctoral position in microfluidics for life and medical sciences at Technion -Israel Institute of Technology

    E-Print Network [OSTI]

    Rimon, Elon

    Postdoctoral position in microfluidics for life and medical sciences at Technion - Israel Institute of Technology The Microfluidic Technologies Laboratory at Technion, led by Prof. Moran Bercovici, is seeking of novel bio-microfluidic tools and assays. The Microfluidic Technologies Laboratory (microfluidics

  19. Newton Institute Workshop NonEquilibrium Dynamics of Interacting Particle Systems

    E-Print Network [OSTI]

    Evans, Denis

    be derived from Gauss' Principle of Least Constraint (Evans, Hoover, Failor, Moran & Ladd (1983)). The formBT / 2( )-1[ ]/ 2 then , in an ergodic system the equilibrium distribution is canonical f() ~ exp[-H0;Thermostatted Response theory Assume system is canonical at t=0. f(,0) = exp[-H0()] d exp[-H0()] f(,t) = exp

  20. S F BOYS -A RAHMAN LECTURE Chaos, Lyapunov Exponents and Transport

    E-Print Network [OSTI]

    Evans, Denis

    be derived from Gauss' Principle of Least Constraint (Evans, Hoover, Failor, Moran & Ladd (1983)). The form = ( ) ( )-[ ] 2 2 2 3 2 1/ / / / then , in an ergodic system the equilibrium distribution is canonical f H k TB( ) ~ exp[ ( ) / ] - 0 . Boys-Rahman Lecture 5 #12;Thermostatted Response theory Assume system is canonical

  1. Models of Tet-On System with Epigenetic Effects Russ Harmer1

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    : this involves the artificial TF rtTA, activated by binding with doxycycline Doxi. Extracellular doxycycline Doxe and activa- tion of fluorescence: this includes transcription, translation and GFP activation. Doxe Deff --- Doxe + Doxi (1) Doxi Deff --- (2) rtTA + Doxi kf2 ---- kr2 rtTA Dox (3) rtTA Dox Sm -- rtTA Dox

  2. What are the shapes of response time distributions in visual search?

    E-Print Network [OSTI]

    Palmer, Evan M.

    Many visual search experiments measure response time (RT) as their primary dependent variable. Analyses typically focus on mean (or median) RT. However, given enough data, the RT distribution can be a rich source of ...

  3. Synthesis of a proteasome inhibitor containing a [Gamma]- lactam-[Beta]-lactone fused ring system

    E-Print Network [OSTI]

    Urbina, Armando

    2009-01-01T23:59:59.000Z

    cool to rt, diluted with MTBE (2.7 L, 15 vol. ), washed withwas cooled to rt, added MTBE (1.0 L, ~20 vol. ) and adjusted

  4. Data:3ecf55b6-1020-4bb7-a123-24306f10c4ae | Open Energy Information

    Open Energy Info (EERE)

    Description: RAPID TRANSIT SERVICE SCHEDULE RT Source or reference: http:www.pepco.comresdocumentsDCRatesRT.pdf Source Parent: Comments Applicability Demand (kW)...

  5. APPUNTI DALLE LEZIONI DI ISTITUZIONI DI FISICA MATEMATICA

    E-Print Network [OSTI]

    Bologna, Università di

    seicento. Dunque questo modello meccanico rende conto di una legge termodinamica macroscopica (pV = RT

  6. Surface Motion Due to Crystalline Surface Energy Gradient Flows Jean E. Taylor, Mathematics Department, Rutgers University, Piscataway, NJ 08*

    E-Print Network [OSTI]

    Taylor, Jean

    ], [CRCT], [CT], [RT]), or Fred Almgren (Princeton) and Lihe Wang (Iowa) ([ATW] [A* *T]). An abbreviated

  7. Course helps professionals develop watershed protection plans: Texas water resources professionals gather

    E-Print Network [OSTI]

    Jensen, Ric

    2008-01-01T23:59:59.000Z

    tx H2O | pg. 6 Story by Ric Jensen Course helps professionals develop watershed protection plans | pg. 6 tx H2O | pg. 7 W ater resources professionals wanting training on watershed protection plan development are benefiting from a course... Casebolt of Texas State Soil and Water Conservation Board, Lucas Gregory of Texas Water Resources Institute, Vanessa Escobar of the Texas Water Development Board, and Ernest Moran of the San Antonio River Author- ity calculate load duration curves...

  8. Gifted Children's Communication about Bullying: Understanding the Experience

    E-Print Network [OSTI]

    Jumper, Rachel Leah

    2011-02-22T23:59:59.000Z

    of intelligence promotes a ?hands on? and varied curriculum that allows children to learn about subjects from a variety of projects (Blythe & Gardner, 1990). Gardner and Moran (2006) write that the theory of multiple intelligences defines intelligence as, ?a... GIFTED CHILDREN?S COMMUNICATION ABOUT BULLYING: UNDERSTANDING THE EXPERIENCE A Dissertation by RACHEL LEAH JUMPER Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements...

  9. 9 Modelling the CoCoME with the JAVA/A Component Model

    E-Print Network [OSTI]

    Gilmore, Stephen

    checking tools HUGO/RT and LTSA to verify that components comply to their ports and that connected ports the absence of deadlocks in composed be- haviours. Since HUGO/RT and LTSA are general model checking tools we

  10. http://pss.sagepub.com/ Psychological Science

    E-Print Network [OSTI]

    Oregon, University of

    performance using absolute reaction time (RT)--a measure that is not sensitive to search efficiency--they do

  11. Time and Encoding Effects in the Concealed Knowledge Test

    E-Print Network [OSTI]

    Seymour, Travis L.; Fraynt, Becky R.

    2009-01-01T23:59:59.000Z

    items). This weapon-focus effect has been demonstrated ina weapon) seem Table 2 Mean concealed knowledge effect on RT

  12. a difference Please help us plant trees!

    E-Print Network [OSTI]

    .m.-1:00 p.m. Berry Brook Restoration Site Why? The trees will enhance the wildlife habitat along the newly created wetland and stream channel and help to filter pollutants and make the stream bank more to the Berry Brook Restoration Site: From Rt. 16 ­Take Exit 9 toward Rt-9/Dover/Rt 108/Somersworth. Take

  13. Time Series Models for Measuring Market Risk Time Series Models for Measuring Market Risk

    E-Print Network [OSTI]

    Hernndez Lobato, Jos Miguel

    and collaborative mixtures of experts 3 GARCH processes with non-parametric innovations 4 Conclusions and future Competitive and collaborative mixtures of experts 3 GARCH processes with non-parametric innovations 4 Volatility models: GARCH processes We say {rt}T t=1 follows a GARCH(1,1) process if: rt = tt (4) 2 t = + |rt

  14. A CSP View on UMLRT structure diagrams Clemens Fischer, ErnstRudiger Olderog and Heike Wehrheim

    E-Print Network [OSTI]

    Habel, Annegret

    A CSP View on UMLRT structure diagrams Clemens Fischer, ErnstRudiger Olderog and Heike Wehrheim UMLRT structure diagrams together with the formal method CSPOZ combining CSP and ObjectZ. While CSPOZ is used for specifying the system components themselves (by CSPOZ classes), UMLRT diagrams provide

  15. Input Routing Determining the next hop with ip_route_input()

    E-Print Network [OSTI]

    Westall, James M.

    _route_input(struct sk_buff *skb, u32 daddr, u32 saddr, u8 tos, struct net_device *dev) 1624 { 1625 struct rtable * rth; 1626 unsigned hash; 1627 int iif = dev->ifindex; 1628 1629 tos &= IPTOS_RT_MASK; The rt_hash_code(daddr, saddr ^ (iif tos); The hash function is implemented by the inline function rt

  16. El dramaturgo Eduardo Sarls

    E-Print Network [OSTI]

    Pignataro Calero, Jorge

    1998-10-01T23:59:59.000Z

    dir. y act. Marisa Montana (en Flannagan). Reposicin, 1988 en Alianza Ur.-EE.UU., dir. Elena Zuasti, act. Cristina Moran. Estrenada en Tarragona, Espaa en 1987. 1986. Delmira Agustini o La dama de Knossos. Dir. Elena Zuasti (en Alianza). Primer... el 28 de abril de 1938 en Budapest, lleg de su Hungra natal a Montevideo en 1948 junto a su madre y una ta, nicos sobrevivientes de una familia juda diezmada por el nazismo y sus campos de concentracin. La adaptacin y asimilacin del nio...

  17. QER- Comment of E. Winkler

    Broader source: Energy.gov [DOE]

    I am one of many rejecting the idea of the proposed Kinder Moran pipeline. The people don't want to pay for a multibillionaire's expansion of his fossil fuel kingdom. Also, the methane pollution of this form of energy is not "clean energy." And most importantly it is destructive to the earth and the health of the people. As stewards of the planet, we must do better, and we are doing better, with cleaner and more economical forms of energy. Please, have a conscience and a vision. No fracked gas pipeline expansion.

  18. Stat 39100/FinMath 34600 Lecture 6 AMERICAN OPTIONS

    E-Print Network [OSTI]

    Mykland, Per A.

    ]t = vL (St)dSt - dDt where, since dSt = d[e-rt St] = -re-rt Stdt + e-rt dSt: dDt = e-rt rvL (St)dt - rv 0 rvL (x) - rxvL (x) - 1 2 2 x2 vL (x) = 0 if x > L rK if x dDt = e-rt rvL (St) - rvL (St

  19. Retail Electricity Competition

    E-Print Network [OSTI]

    Joskow, Paul; Tirole, Jean

    2004-06-16T23:59:59.000Z

    ?P [ max s E [S (s, ?) ? p ? D (s, ?) | ? ? P ] ] ? C(P) } . (7) This utility is maximized when the consumer is confronted with the wholesale prices: p? ? = p ? . Proposition 4 With real-time meters and imperfectly reactive, but rational consumers: (i... purchase cost corresponds to: 1 entire consumption profile (RT meter) yes customers RT profile 2 entire consumption profile (RT meter) no / partial customers RT profile 3 aggregate consumption only (traditional meter) no customers RT profile 4 aggregate...

  20. An overview of craniospinal axis fields and field matching

    SciTech Connect (OSTI)

    Scott, Robin L., E-mail: robinscott631@gmail.com

    2013-01-01T23:59:59.000Z

    Many methods are implemented for craniospinal axis (CSA) radiation treatment (RT). This papers goal is to define correctly matched CSA RT fields. Overlap or a space between matched RT fields can create variances of dose and the possibility of negative side effects or disease recurrence, respectively. An accurate CSA RT match procedure is created with localization markers, immobilization devices, equations, feathered matches, safety gap, and portal imaging. A CS match angle is predetermined to optimize patient position before immobilization device fabrication. Various central axis (CA) placements within the brain and spine fields that effect gantry, table, and collimator rotation are described. An overview of the methods used to create CSA RT fields and matches is presented for optimal CSA RT implementation. In addition, to the authors knowledge, this is the first time that a prone CSA RT with anesthesia has been described.

  1. RADIO FREQUENCY IDENTIFICATION DEVICES: EFFECTIVENESS IN IMPROVING SAFEGUARDS AT GAS-CENTRIFUGE URANIUM-ENRICHMENT PLANTS.

    SciTech Connect (OSTI)

    JOE,J.

    2007-07-08T23:59:59.000Z

    Recent advances in radio frequency identification devices (RFIDs) have engendered a growing interest among international safeguards experts. Potentially, RFIDs could reduce inspection work, viz. the number of inspections, number of samples, and duration of the visits, and thus improve the efficiency and effectiveness of international safeguards. This study systematically examined the applications of RFIDs for IAEA safeguards at large gas-centrifuge enrichment plants (GCEPs). These analyses are expected to help identify the requirements and desirable properties for RFIDs, to provide insights into which vulnerabilities matter most, and help formulate the required assurance tests. This work, specifically assesses the application of RFIDs for the ''Option 4'' safeguards approach, proposed by Bruce Moran, U. S. Nuclear Regulatory Commission (NRC), for large gas-centrifuge uranium-enrichment plants. The features of ''Option 4'' safeguards include placing RFIDs on all feed, product and tails (F/P/T) cylinders, along with WID readers in all FP/T stations and accountability scales. Other features of Moran's ''Option 4'' are Mailbox declarations, monitoring of load-cell-based weighing systems at the F/P/T stations and accountability scales, and continuous enrichment monitors. Relevant diversion paths were explored to evaluate how RFIDs improve the efficiency and effectiveness of safeguards. Additionally, the analysis addresses the use of RFIDs in conjunction with video monitoring and neutron detectors in a perimeter-monitoring approach to show that RFIDs can help to detect unidentified cylinders.

  2. Improved Posttreatment Functional Outcome is Associated with Better Survival in Patients Irradiated for Metastatic Spinal Cord Compression

    SciTech Connect (OSTI)

    Rades, Dirk [Department of Radiation Oncology, University Hospital Schleswig-Holstein, Luebeck (Germany) and Department of Radiation Oncology, University Hospital Hamburg-Eppendorf, Hamburg (Germany)]. E-mail: Rades.Dirk@gmx.net; Veninga, Theo [Department of Radiation Oncology, Dr. Bernard Verbeeten Institute, Tilburg (Netherlands); Stalpers, Lukas J.A. [Department of Radiotherapy, Academic Medical Center, Amsterdam (Netherlands); Basic, Hiba [Department of Radiation Oncology, University Hospital, Sarajevo (Bosnia and Herzegowina); Hoskin, Peter J. [Mount Vernon Centre for Cancer Treatment, Northwood, Middlesex (United Kingdom); Karstens, Johann H. [Department of Radiation Oncology, Medical School Hannover, Hannover (Germany); Schild, Steven E. [Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ (United States); Dunst, Juergen [Department of Radiation Oncology, University Hospital Schleswig-Holstein, Luebeck (Germany)

    2007-04-01T23:59:59.000Z

    Purpose: To evaluate the potential prognostic impact of the effect of radiotherapy (RT) on motor function and of the post-RT ambulatory status on survival in metastatic spinal cord compression (MSCC) patients. Methods and Materials: Of 1,852 patients irradiated for MSCC, 778 patients (42%) received short-course RT and 1,074 (58%) received long-course RT. The effect of RT on motor function (improvement vs. no change vs. deterioration) and the ambulatory status after RT (ambulatory vs. nonambulatory) were evaluated with respect to survival. Results: The actuarial survival rate of the entire cohort was 56% at 6 months, 43% at 12 months, and 32% at 24 months. The patients in whom motor function improved after RT had a significantly better 1-year survival rate than those who had no change or deterioration of motor function (75% vs. 40% and 3%, p < 0.001). The 1-year survival rate of the patients who were ambulatory after RT was significantly better than for those who were not ambulatory (63% vs. 4%, p < 0.001). The results were confirmed in multivariate analysis. Conclusions: The response to RT and the post-RT ambulatory status are important predictors for survival in MSCC patients. This finding can be used by physicians to stratify future studies, plan further therapy, and improve follow-up strategy in these patients.

  3. Hepatocellular Carcinoma Radiation Therapy: Review of Evidence and Future Opportunities

    SciTech Connect (OSTI)

    Klein, Jonathan [Department of Radiation Oncology, Princess Margaret Hospital/University of Toronto, Toronto, Ontario (Canada); Dawson, Laura A., E-mail: laura.dawson@rmp.uhn.on.ca [Department of Radiation Oncology, Princess Margaret Hospital/University of Toronto, Toronto, Ontario (Canada)

    2013-09-01T23:59:59.000Z

    Hepatocellular carcinoma (HCC) is a leading cause of global cancer death. Curative therapy is not an option for most patients, often because of underlying liver disease. Experience in radiation therapy (RT) for HCC is rapidly increasing. Conformal RT can deliver tumoricidal doses to focal HCC with low rates of toxicity and sustained local control in HCC unsuitable for other locoregional treatments. Stereotactic body RT and particle therapy have been used with long-term control in early HCC or as a bridge to liver transplant. RT has also been effective in treating HCC with portal venous thrombosis. Patients with impaired liver function and extensive disease are at increased risk of toxicity and recurrence. More research on how to combine RT with other standard and novel therapies is warranted. Randomized trials are also needed before RT will be generally accepted as a treatment option for HCC. This review discusses the current state of the literature and opportunities for future research.

  4. Prediction of Liver Function by Using Magnetic Resonance-based Portal Venous Perfusion Imaging

    SciTech Connect (OSTI)

    Cao Yue, E-mail: yuecao@umich.edu [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States); Department of Radiology, University of Michigan, Ann Arbor, Michigan (United States); Wang Hesheng [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States); Johnson, Timothy D. [Department of Biostatistics, University of Michigan, Ann Arbor, Michigan (United States)] [Department of Biostatistics, University of Michigan, Ann Arbor, Michigan (United States); Pan, Charlie [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States); Hussain, Hero [Department of Radiology, University of Michigan, Ann Arbor, Michigan (United States)] [Department of Radiology, University of Michigan, Ann Arbor, Michigan (United States); Balter, James M.; Normolle, Daniel; Ben-Josef, Edgar; Ten Haken, Randall K.; Lawrence, Theodore S.; Feng, Mary [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States)] [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States)

    2013-01-01T23:59:59.000Z

    Purpose: To evaluate whether liver function can be assessed globally and spatially by using volumetric dynamic contrast-enhanced magnetic resonance imaging MRI (DCE-MRI) to potentially aid in adaptive treatment planning. Methods and Materials: Seventeen patients with intrahepatic cancer undergoing focal radiation therapy (RT) were enrolled in institution review board-approved prospective studies to obtain DCE-MRI (to measure regional perfusion) and indocyanine green (ICG) clearance rates (to measure overall liver function) prior to, during, and at 1 and 2 months after treatment. The volumetric distribution of portal venous perfusion in the whole liver was estimated for each scan. We assessed the correlation between mean portal venous perfusion in the nontumor volume of the liver and overall liver function measured by ICG before, during, and after RT. The dose response for regional portal venous perfusion to RT was determined using a linear mixed effects model. Results: There was a significant correlation between the ICG clearance rate and mean portal venous perfusion in the functioning liver parenchyma, suggesting that portal venous perfusion could be used as a surrogate for function. Reduction in regional venous perfusion 1 month after RT was predicted by the locally accumulated biologically corrected dose at the end of RT (P<.0007). Regional portal venous perfusion measured during RT was a significant predictor for regional venous perfusion assessed 1 month after RT (P<.00001). Global hypovenous perfusion pre-RT was observed in 4 patients (3 patients with hepatocellular carcinoma and cirrhosis), 3 of whom had recovered from hypoperfusion, except in the highest dose regions, post-RT. In addition, 3 patients who had normal perfusion pre-RT had marked hypervenous perfusion or reperfusion in low-dose regions post-RT. Conclusions: This study suggests that MR-based volumetric hepatic perfusion imaging may be a biomarker for spatial distribution of liver function, which could aid in individualizing therapy, particularly for patients at risk for liver injury after RT.

  5. Historical Trends in the Use of Radiation Therapy for Pediatric Cancers: 1973-2008

    SciTech Connect (OSTI)

    Jairam, Vikram [Yale School of Medicine, Department of Therapeutic Radiology, New Haven, Connecticut (United States)] [Yale School of Medicine, Department of Therapeutic Radiology, New Haven, Connecticut (United States); Roberts, Kenneth B. [Yale School of Medicine, Department of Therapeutic Radiology, New Haven, Connecticut (United States) [Yale School of Medicine, Department of Therapeutic Radiology, New Haven, Connecticut (United States); Yale Cancer Center, New Haven, Connecticut (United States); Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center at Yale, New Haven, Connecticut (United States); Yu, James B., E-mail: james.b.yu@yale.edu [Yale School of Medicine, Department of Therapeutic Radiology, New Haven, Connecticut (United States); Yale Cancer Center, New Haven, Connecticut (United States); Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center at Yale, New Haven, Connecticut (United States)

    2013-03-01T23:59:59.000Z

    Purpose: This study was undertaken to assess historical trends in the use of radiation therapy (RT) for pediatric cancers over the past 4 decades. Methods: The National Cancer Institute's Surveillance, Epidemiology, and End Results database of the 9 original tumor registries (SEER-9) was queried to identify patients aged 0 to 19 years with acute lymphoblastic leukemia, acute myeloid leukemia, bone and joint cancer, cancer of the brain and nervous system, Hodgkin lymphoma, neuroblastoma, non-Hodgkin lymphoma, soft tissue cancer, Wilms tumor, or retinoblastoma from 1973 to 2008. Patients were grouped into 4-year time epochs. The number and percentage of patients who received RT as part of their initial treatment were calculated per epoch by each diagnosis group from 1973 to 2008. Results: RT use for acute lymphoblastic leukemia, non-Hodgkin lymphoma, and retinoblastoma declined sharply from 57%, 57%, and 30% in 1973 to 1976 to 11%, 15%, and 2%, respectively, in 2005 to 2008. Similarly, smaller declines in RT use were also seen in brain cancer (70%-39%), bone cancer (41%-21%), Wilms tumor (75%-53%), and neuroblastoma (60%-25%). RT use curves for Wilms tumor and neuroblastoma were nonlinear with nadirs in 1993 to 1996 at 39% and 19%, respectively. There were minimal changes in RT use for Hodgkin lymphoma, soft tissue cancer, or acute myeloid leukemia, roughly stable at 72%, 40%, and 11%, respectively. Almost all patients treated with RT were given external beam RT exclusively. However, from 1985 to 2008, treatments involving brachytherapy, radioisotopes, or combination therapy increased in frequency, comprising 1.8%, 4.6%, and 11.9% of RT treatments in brain cancer, soft tissue cancer, and retinoblastoma, respectively. Conclusions: The use of RT is declining over time in 7 of 10 pediatric cancer categories. A limitation of this study is a potential under-ascertainment of RT use in the SEER-9 database including the delayed use of RT.

  6. Free Energy Calculation in MD Simulation

    E-Print Network [OSTI]

    Nielsen, Steven O.

    Free Energy Calculation in MD Simulation #12;Basic Thermodynamics Helmoholtz free energy A = U TS + i Ni dA = wrev (reversible, const N V T) eq (22.9) McQuarrie & Simon Gibbs free energy G = U;Implication of Free Energy A B Keq = [A]/[B] Keq = exp (-G0 /RT) G0 = -RT ln Keq G = G0 + RT ln Q G > 0

  7. Association of Clinical Response and Long-term Outcome Among Patients With Biopsied Orbital Pseudotumor Receiving Modern Radiation Therapy

    SciTech Connect (OSTI)

    Prabhu, Roshan S., E-mail: rprabhu@emory.edu [Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Kandula, Shravan; Liebman, Lang [Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, Georgia (United States)] [Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Wojno, Ted H.; Hayek, Brent [Division of Oculoplastics, Orbital and Cosmetic Surgery, Emory University, Atlanta, Georgia (United States)] [Division of Oculoplastics, Orbital and Cosmetic Surgery, Emory University, Atlanta, Georgia (United States); Hall, William A.; Shu, Hui-Kuo; Crocker, Ian [Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, Georgia (United States)] [Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, Georgia (United States)

    2013-03-01T23:59:59.000Z

    Purpose: To retrospectively evaluate institutional outcomes for patients treated with modern radiation therapy (RT) for biopsied orbital pseudotumor (OP). Methods and Materials: Twenty patients (26 affected orbits) with OP were treated with RT between January 2002 and December 2011. All patients underwent biopsy with histopathologic exclusion of other disease processes. Sixteen patients (80%) were treated with intensity modulated RT, 3 (15%) with opposed lateral beams, and 1 (5%) with electrons. Median RT dose was 27 Gy (range 25.2-30.6 Gy). Response to RT was evaluated at 4 months post-RT. Partial response (PR) was defined as improvement in orbital symptoms without an increase in steroid dose. Complete response (CR) 1 and CR 2 were defined as complete resolution of orbital symptoms with reduction in steroid dose (CR 1) or complete tapering of steroids (CR 2). The median follow-up period was 18.6 months (range 4-81.6 months). Results: Seventeen patients (85%) demonstrated response to RT, with 7 (35%), 1 (5%), and 9 (45%) achieving a PR, CR 1, and CR 2, respectively. Of the 17 patients who had ?PR at 4 months post-RT, 6 (35%) experienced recurrence of symptoms. Age (>46 years vs ?46 years, P=.04) and clinical response to RT (CR 2 vs CR 1/PR, P=.05) were significantly associated with pseudotumor recurrence. Long-term complications were seen in 7 patients (35%), including 4 with cataract formation, 1 with chronic dry eye, 1 with enophthalmos, and 1 with keratopathy. Conclusions: RT is an effective treatment for improving symptoms and tapering steroids in patients with a biopsy supported diagnosis of OP. Older age and complete response to RT were associated with a significantly reduced probability of symptom recurrence. The observed late complications may be related to RT, chronic use of steroids/immunosuppressants, medical comorbidities, or combination of factors.

  8. Rayleigh-Taylor instability in an equal mass plasma

    SciTech Connect (OSTI)

    Adak, Ashish, E-mail: ashish-adak@yahoo.com [Department of Instrumentation Science, Jadavpur University, Kolkata 700 032 (India); Ghosh, Samiran, E-mail: sran-g@yahoo.com [Department of Applied Mathematics, University of Calcutta 92, Acharya Prafulla Chandra Road, Kolkata 700 009 (India); Chakrabarti, Nikhil, E-mail: nikhil.chakrabarti@saha.ac.in [Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700 064 (India)

    2014-09-15T23:59:59.000Z

    The Rayleigh-Taylor (RT) instability in an inhomogeneous pair-ion plasma has been analyzed. Considering two fluid model for two species of ions (positive and negative), we obtain the possibility of the existence of RT instability. The growth rate of the RT instability as usual depends on gravity and density gradient scale length. The results are discussed in context of pair-ion plasma experiments.

  9. abdominal catastrophe caused: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of the asymptotic attractor. For fractal basin Lai, Ying-Cheng 48 Climate Change: A Catastrophe in Slow Motion R.T. Pierrehumbert* Geosciences Websites Summary: of...

  10. A, E.K.Ris Ris-M-OHj Title and authors)

    E-Print Network [OSTI]

    or group Department of fee-'tor Technology Group's own registration numbers) RT-^-*5 Abstract The work seven of the Department'a graduate

  11. 248 K. Jareteg et al. / Annals of Nuclear Energy 68 (2014) 247256 Even though such approaches have been proven to give reason

    E-Print Network [OSTI]

    Demazire, Christophe

    2014-01-01T23:59:59.000Z

    tron diffusion approximation (Bell and Glasstone, 1970): Z 1 rDr;ErUr;ERT r;EUr;E Rs0r;E0

  12. Nr. 178 / 2013 // 28. Juni 2013 Einweihung des NW III am 4. Juli 2013

    E-Print Network [OSTI]

    Ott, Albrecht

    verbessern", erklärt Dr. Markus Zanner, Kanzler der Universität Bayreuth. Das Gebäude weist 3.335 qm

  13. PR~AIaGI~TRAnON 'l.Ellgu.;Ui~, "

    E-Print Network [OSTI]

    Kaminsky, Werner

    ,omores. SchediJles willbemailed JuneJ4! , .~; Rt!~red Students Stl:ldc;p.t:swho preregister and do no~ get

  14. Development and validation of transgene constructs in order to generate bi-transgenic mice models for Diabetic Peripheral Neuropathy research

    E-Print Network [OSTI]

    Nair, Lakshmy

    2010-04-09T23:59:59.000Z

    of the reverse tetracycline-controlled transactivator protein (rtTA), called rtTA-Advanced (Figure 3c). It is more sensitive to doxycycline (Dox) and yields lower background expression than the original rtTA[21]. The rtTA-Advanced protein is a fusion of amino... advantage of using one system over the other[21]. With the Tet-Off system, it is necessary to keep tetracycline (Tc) or doxycycline (Dox) in the medium to maintain the native (off) state. Due to the relatively short half-lives of Tc and Dox, one must add...

  15. Mobilization of Viable Tumor Cells Into the Circulation During Radiation Therapy

    SciTech Connect (OSTI)

    Martin, Olga A. [Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne, VIC (Australia); Molecular Radiation Biology Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC (Australia); The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC (Australia); Anderson, Robin L. [The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC (Australia); Metastasis Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC (Australia); Russell, Prudence A. [Department of Anatomical Pathology, St. Vincent Hospital, Fitzroy, VIC (Australia); Ashley Cox, R. [Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne, VIC (Australia); Ivashkevich, Alesia [Molecular Radiation Biology Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC (Australia); Laboratory of DNA Repair and Genomics, Centre for Innate Immunity and Infectious Disease, Monash Institute for Medical Research, Monash University, Clayton, VIC (Australia); Swierczak, Agnieszka; Doherty, Judy P. [Metastasis Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC (Australia); Jacobs, Daphne H.M. [Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne, VIC (Australia); Smith, Jai [Molecular Radiation Biology Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC (Australia); Siva, Shankar; Daly, Patricia E. [Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne, VIC (Australia); Ball, David L. [Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne, VIC (Australia); The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC (Australia); and others

    2014-02-01T23:59:59.000Z

    Purpose: To determine whether radiation therapy (RT) could mobilize viable tumor cells into the circulation of non-small cell lung cancer (NSCLC) patients. Methods and Materials: We enumerated circulating tumor cells (CTCs) by fluorescence microscopy of blood samples immunostained with conventional CTC markers. We measured their DNA damage levels using ?-H2AX, a biomarker for radiation-induced DNA double-strand breaks, either by fluorescence-activated cell sorting or by immunofluorescence microscopy. Results: Twenty-seven RT-treated NSCLC patients had blood samples analyzed by 1 or more methods. We identified increased CTC numbers after commencement of RT in 7 of 9 patients treated with palliative RT, and in 4 of 8 patients treated with curative-intent RT. Circulating tumor cells were also identified, singly and in clumps in large numbers, during RT by cytopathologic examination (in all 5 cases studied). Elevated ?-H2AX signal in post-RT blood samples signified the presence of CTCs derived from irradiated tumors. Blood taken after the commencement of RT contained tumor cells that proliferated extensively in vitro (in all 6 cases studied). Circulating tumor cells formed ?-H2AX foci in response to ex vivo irradiation, providing further evidence of their viability. Conclusions: Our findings provide a rationale for the development of strategies to reduce the concentration of viable CTCs by modulating RT fractionation or by coadministering systemic therapies.

  16. POLTICAS PBLICAS E A DIFICULDADE DE EFETIVAR DIREITOS SOCIAIS NO BRASIL

    E-Print Network [OSTI]

    Cangussu, Brbara Ferreira; Maringues de Aquino, Larissa Alvarenga

    2012-01-01T23:59:59.000Z

    Paulo: Malheiros, 2011. BRASIL. CLT Saraiva & ConstituioSo Paulo: Saraiva, 2011. BRASIL. Cdigo penal, cdigo dee atual.. So Paulo: RT, 2008. BRASIL. Constituio (1891).

  17. Effects of Resistance Trainging and -hydroxy--methylbutyrate (HMB) on Muscle Fiber CSA and Lean Body Mass in Aged Rats: A DTI and DEXA Study

    E-Print Network [OSTI]

    McQuade, D. Tyler

    and volumetric measurements. In vivo and prior to sacrifice, pre- and post-RT LBM was assessed by dual energy X

  18. Pioneering Research Powering Clinical Outcomes

    E-Print Network [OSTI]

    New Mexico, University of

    Pioneering Research Powering Clinical Outcomes AnnuAl RepoRt of ContRACts And GRAnts, 2011 #12 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Clinical and Translational Science Center Affiliated Grants

  19. -TU3.fs S$Ee{rsrRY SBFaR?}dEtSr tne sfflclal" records af Tufte 6o1J.ege for the year 18bS

    E-Print Network [OSTI]

    Kounaves, Samuel P.

    &themtics and piiysieB" 'fbe recorda aleo ehow th*rt he held thie Bositlon until 186S wiren he was relreved of two c

  20. Predictive Models for Regional Hepatic Function Based on 99mTc-IDA SPECT and Local Radiation Dose for Physiologic Adaptive Radiation Therapy

    SciTech Connect (OSTI)

    Wang, Hesheng, E-mail: hesheng@umich.edu [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States); Feng, Mary [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States); Frey, Kirk A. [Department of Radiology, University of Michigan, Ann Arbor, Michigan (United States); Ten Haken, Randall K.; Lawrence, Theodore S. [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States); Cao, Yue [Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan (United States); Department of Radiology, University of Michigan, Ann Arbor, Michigan (United States); Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan (United States)

    2013-08-01T23:59:59.000Z

    Purpose: High-dose radiation therapy (RT) for intrahepatic cancer is limited by the development of liver injury. This study investigated whether regional hepatic function assessed before and during the course of RT using 99mTc-labeled iminodiacetic acid (IDA) single photon emission computed tomography (SPECT) could predict regional liver function reserve after RT. Methods and Materials: Fourteen patients treated with RT for intrahepatic cancers underwent dynamic 99mTc-IDA SPECT scans before RT, during, and 1 month after completion of RT. Indocyanine green (ICG) tests, a measure of overall liver function, were performed within 1 day of each scan. Three-dimensional volumetric hepatic extraction fraction (HEF) images of the liver were estimated by deconvolution analysis. After coregistration of the CT/SPECT and the treatment planning CT, HEF doseresponse functions during and after RT were generated. The volumetric mean of the HEFs in the whole liver was correlated with ICG clearance time. Three models, dose, priori, and adaptive models, were developed using multivariate linear regression to assess whether the regional HEFs measured before and during RT helped predict regional hepatic function after RT. Results: The mean of the volumetric liver HEFs was significantly correlated with ICG clearance half-life time (r=?0.80, P<.0001), for all time points. Linear correlations between local doses and regional HEFs 1 month after RT were significant in 12 patients. In the priori model, regional HEF after RT was predicted by the planned dose and regional HEF assessed before RT (R=0.71, P<.0001). In the adaptive model, regional HEF after RT was predicted by regional HEF reassessed during RT and the remaining planned local dose (R=0.83, P<.0001). Conclusions: 99mTc-IDA SPECT obtained during RT could be used to assess regional hepatic function and helped predict post-RT regional liver function reserve. This could support individualized adaptive radiation treatment strategies to maximize tumor control and minimize the risk of liver damage.

  1. 66 PLANTmanagement (PC)

    E-Print Network [OSTI]

    Papadopoulos, Evangelos

    ), (image processing) (DSP). 8-bit, 32-bit, . , - PLC. , , , ( .. ladder PLC), . o, PLC - (.. ). , ( RT-Linux, QNX ..), . , . PLC . laptop 2 , . 2V

  2. Pantex | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    content Social Media Pantex Pantex RT @PantexPlant: Pantex becomes @NWSAmarillo ambassador for severe weather preparedness http:ow.lyB6BX5...

  3. Annoncetillg frA AArhus universitet Kronprinsesse Mary kommer p besg. En

    E-Print Network [OSTI]

    kulminen I Arktis smelter sneen tidligere end for ti år siden. Det har medført, at planternes blomstring er

  4. Reduction of false positives on the rectal tube in computer-aided detection for CT colonography

    SciTech Connect (OSTI)

    Iordanescu, Gheorghe; Summers, Ronald M. [Department of Radiology, National Institutes of Health Building 10, Room 1C660, 10 Center Drive MSC 1182, Bethesda, Maryland 20892-1182 (United States)

    2004-10-01T23:59:59.000Z

    Purpose: To eliminate false-positive (FP) polyp detections on the rectal tube (RT) in CT colonography (CTC) computer-aided detection (CAD). Methods: We use a three-stage approach to detect the RT: detect the RT shaft, track the tube to the tip and label all the voxels that belong to the RT. We applied our RT detection algorithm on a CTC dataset consisting of 80 datasets (40 patients scanned in both prone and supine positions). Two different types of RTs were present, characterized by differences in shaft/bulb diameters, wall intensities, and shape of tip. Results: The algorithm detected 90% of RT shafts and completely tracked 72% of them. We labeled all the voxels belonging to the completely tracked RTs (72%) and in 11 out of 80 (14%) cases the RT voxels were partially labeled. We obtained a 9.2% reduction of the FPs in the initial polyp candidates' population, and a 7.9% reduction of the FPs generated by our CAD system. None of the true-positive detections were mislabeled. Conclusions: The algorithm detects the RTs with good accuracy, is robust with respect to the two different types of RT used in our study, and is effective at reducing the number of RT FPs reported by our CAD system.

  5. Nanoscale optoentropic transduction mechanisms

    E-Print Network [OSTI]

    Sullivan, Benjamin David

    2007-01-01T23:59:59.000Z

    of detection of tyrosinase and MART-1 transcripts in theused for lung cancer; tyrosinase expression for melanoma;W. Multiple RT-PCR tyrosinase testing reveals that melanoma

  6. A viral resistance gene from common bean functions across plant families and is up-regulated in a non-virus-specific manner.

    E-Print Network [OSTI]

    2006-01-01T23:59:59.000Z

    susceptible (cv. Topcrop) common bean cultivars inoculatedline RT6) and common bean (cv. Othello) plants. Symptomssymptoms induced by the bean-infecting strain 67 (subgroup

  7. PUBLICATIONS Baer, T., Gore, J. C., Boyce, S., & Nye, P. W. (1987). Application of MRI to the analysis of

    E-Print Network [OSTI]

    1987-01-01T23:59:59.000Z

    ._rwodi REPORT DOCUMENTATION PAGE Rt,~1> INSTRI crIO'" BEFORt COMPLET,M. FORM I. IIEPORl IUIlBER 12 1l0Vl

  8. ancient geologic samples: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    superconducting quantum interference device SQUID-temperature RT sample scanning superconduct- ing quantum interference device SQUID microscopy SSM is a very Weiss, Benjamin P....

  9. anomalous quantum interference: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    superconducting quantum interference device SQUID-temperature RT sample scanning superconduct- ing quantum interference device SQUID microscopy SSM is a very Weiss, Benjamin P....

  10. arrested development high-resolution: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    superconducting quantum interference device SQUID-temperature RT sample scanning superconduct- ing quantum interference device SQUID microscopy SSM is a very Weiss, Benjamin P....

  11. aerobic room temperature: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    superconducting quantum interference device SQUID-temperature RT sample scanning superconduct- ing quantum interference device SQUID microscopy SSM is a very Weiss, Benjamin P....

  12. Use of External Beam Radiotherapy Is Associated With Reduced Incidence of Second Primary Head and Neck Cancer: A SEER Database Analysis

    SciTech Connect (OSTI)

    Rusthoven, Kyle [Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO (United States); Chen Changhu [Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO (United States)], E-mail: Changhu.Chen@uchsc.edu; Raben, David; Kavanagh, Brian [Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO (United States)

    2008-05-01T23:59:59.000Z

    Purpose: Patients with head and neck cancer have a significant risk of developing a second primary cancer of the head and neck. We hypothesized that treatment with external beam radiotherapy (RT) might reduce this risk, because RT can eradicate occult foci of second head and neck cancer (HNCA). Methods and Materials: The data of patients with Surveillance, Epidemiology, and End Results Historic Stage A localized squamous cell carcinoma of the oral cavity, larynx, and pharynx were queried using the Surveillance, Epidemiology, and End Results database. For patients treated with or without RT, the incidence of second HNCA was determined and compared using the log-rank method. Cox proportional hazards analysis was performed for each site, evaluating the influence of covariates on the risk of second HNCA. Results: Between 1973 and 1997, 27,985 patients were entered with localized HNCA. Of these patients, 44% had received RT and 56% had not. The 15-year incidence of second HNCA was 7.7% with RT vs. 10.5% without RT (hazard ratio 0.71, p <0.0001). The effect of RT was more profound in patients diagnosed between 1988 and 1997 (hazard ratio 0.53, p <0.0001) and those with pharynx primaries (hazard ratio 0.47, p <0.0001). On multivariate analysis, RT was associated with a reduced risk of second HNCA for pharynx (p <0.0001) and larynx (p = 0.04) tumors. For oral cavity primaries, RT was associated with an increased risk of second HNCA in patients treated before 1988 (p <0.001), but had no influence on patients treated between 1988 and 1997 (p = 0.91). Conclusion: For localized HNCA, RT is associated with a reduced incidence of second HNCA. These observations are consistent with the eradication of microscopic foci of second HNCA with external beam RT.

  13. Respiratory triggered 4D cone-beam computed tomography: A novel method to reduce imaging dose

    SciTech Connect (OSTI)

    Cooper, Benjamin J. [Radiation Physics Laboratory, Sydney Medical School, University of Sydney, NSW 2006, Australia and Department of Medical Physics and Radiation Engineering, Canberra Hospital, Canberra, ACT 2605 (Australia); O'Brien, Ricky T.; Keall, Paul J. [Radiation Physics Laboratory, Sydney Medical School, University of Sydney, NSW 2006 (Australia); Balik, Salim; Hugo, Geoffrey D. [Radiation Oncology, Virginia Commonwealth University, 401 College Street, P.O.Box 980058, Richmond, Virginia 23298-0058 (United States)

    2013-04-15T23:59:59.000Z

    Purpose: A novel method called respiratory triggered 4D cone-beam computed tomography (RT 4D CBCT) is described whereby imaging dose can be reduced without degrading image quality. RT 4D CBCT utilizes a respiratory signal to trigger projections such that only a single projection is assigned to a given respiratory bin for each breathing cycle. In contrast, commercial 4D CBCT does not actively use the respiratory signal to minimize image dose. Methods: To compare RT 4D CBCT with conventional 4D CBCT, 3600 CBCT projections of a thorax phantom were gathered and reconstructed to generate a ground truth CBCT dataset. Simulation pairs of conventional 4D CBCT acquisitions and RT 4D CBCT acquisitions were developed assuming a sinusoidal respiratory signal which governs the selection of projections from the pool of 3600 original projections. The RT 4D CBCT acquisition triggers a single projection when the respiratory signal enters a desired acquisition bin; the conventional acquisition does not use a respiratory trigger and projections are acquired at a constant frequency. Acquisition parameters studied were breathing period, acquisition time, and imager frequency. The performance of RT 4D CBCT using phase based and displacement based sorting was also studied. Image quality was quantified by calculating difference images of the test dataset from the ground truth dataset. Imaging dose was calculated by counting projections. Results: Using phase based sorting RT 4D CBCT results in 47% less imaging dose on average compared to conventional 4D CBCT. Image quality differences were less than 4% at worst. Using displacement based sorting RT 4D CBCT results in 57% less imaging dose on average, than conventional 4D CBCT methods; however, image quality was 26% worse with RT 4D CBCT. Conclusions: Simulation studies have shown that RT 4D CBCT reduces imaging dose while maintaining comparable image quality for phase based 4D CBCT; image quality is degraded for displacement based RT 4D CBCT in its current implementation.

  14. Magnetic Activity in Stars, Discs and Quasars

    E-Print Network [OSTI]

    Donald Lynden-Bell

    2000-07-14T23:59:59.000Z

    Although magnetic fields in interstellar matter were postulated almost fifty years ago, magnetohydrodynamic theory was then much hampered by our inability to see what the magnetic field configurations were like and, after a decade of innovative development, cynics, not without some justification, began to claim that anything can happen when magnetism and an imaginative theorist get together. Thus cosmic lightning in particular received a bad press. More recently great advances in observational techniques that we shall hear of from Title, Beck, Moran and Mirabel have enabled us to see not only the sun's magnetic field with unprecedented clarity but the fields in galaxies, quasars and microquasars are now measured and not merely figments of fertile imaginations.

  15. HGS Schedulers for Digital Audio Workstation like Applications

    E-Print Network [OSTI]

    Poduval, Karthik Venugopal

    2014-08-31T23:59:59.000Z

    RT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 3.1.3 Libsynchro . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 3.1.4 Synchro SDF version 2 . . . . . . . . . . . . . . . . . . . . . . . . . . 23 3.2 JACK Integration... 4.1.4 Rt-app Load . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44 v 4.2 JACK with SEQ SDF integration . . . . . . . . . . . . . . . . . . . . . . . . 48 4.2.1 No Load...

  16. Real-time magnetic resonance imagingguided radiofrequency atrial ablation and visualization of lesion formation at 3 Tesla

    E-Print Network [OSTI]

    Utah, University of

    of lesion formation at 3 Tesla Gaston R. Vergara, MD,* Sathya Vijayakumar, MS,* Eugene G. Kholmovski, Ph. In this study, we report a novel 3-Tesla RT -RI based porcine RF ablation model and visuali- zation of lesion-Tesla RT MRI-based catheter ablation and lesion visualization system. METHODS RF energy was delivered

  17. Directions to the National Radio Astronomy Observatory Green Bank, West Virginia

    E-Print Network [OSTI]

    Groppi, Christopher

    Directions to the National Radio Astronomy Observatory Green Bank, West Virginia From Charleston Roanoke, VA: Via I-64 West, exit at White Sulphur Springs (Exit 181) and take Rt. 92 North to Green Bank, then take Rt. 92 South to Green Bank. From Washington DC: Via I-66 West to I-81 South. Option 1: Take I-81

  18. SCHOOL OF MATHEMATICS AND STATISTICS Autumn Semester 20089 Vectors and Motion 2 Hours

    E-Print Network [OSTI]

    t = 0, the particle is at rest at the origin, and find the initial acceler- ation of the particle. (3)] = a ? b (2 marks) At time t, the position vector r(t) of a moving particle is given by r(t) = µ2 [µt

  19. Physics 112 Second Midterm Exam February 22, 2000 MIDTERM EXAM INSTRUCTIONS: You have 90 minutes to complete this

    E-Print Network [OSTI]

    California at Santa Cruz, University of

    to the mixing process? (The gas constant R NAk, where NA is Avogadro's number.) (a) 0 (b) -5RT ln 2 (c) +5RT ln is observed at T = 10, 000 K. The heat capacities of the gas at constant pressure and constant volume decoupled? (It is enough to consider the relative volume occupied by the expanding photon gas.) (a) 103 (b

  20. Surveillance of Craniopharyngioma Cyst Growth in Children Treated With Proton Radiotherapy

    SciTech Connect (OSTI)

    Winkfield, Karen M. [Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA (United States)], E-mail: kwinkfield@partners.org; Linsenmeier, Claudia; Yock, Torunn I. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States); Grant, P. Ellen [Department of Radiology, Massachusetts General Hospital, Boston, MA (United States); Yeap, Beow Y. Sc.D. [Department of Medicine, Massachusetts General Hospital, Boston, MA (United States); Butler, William E. [Department of Neurosurgery, Massachusetts General Hospital, Boston, MA (United States); Tarbell, Nancy J. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States)

    2009-03-01T23:59:59.000Z

    Purpose: Craniopharyngiomas are benign, slow-growing tumors that frequently contain a cystic component. Even with gross total resection, the cyst can reform and cause symptoms. Fluctuations in cyst volume during radiotherapy (RT) can affect treatment planning and delivery. The aim of this study was to report our experience with cyst enlargement during conformal proton RT for children with craniopharyngioma and to make recommendations regarding mid-treatment surveillance. Methods and Materials: Between January 2001 and August 2007, 24 children (aged {<=}18 years) underwent proton RT at the Massachusetts General Hospital for craniopharyngioma. For all 24 patients, tumor size on magnetic resonance imaging and/or computed tomography was measured before and after RT. Surveillance imaging was available for review on 17 patients. During RT, cyst growth was assessed to determine whether the treatment fields needed to be altered. Results: Of the 17 children who underwent repeat imaging during RT, 6 required intervention because of changes in cyst dimensions. Four patients (24%) had cyst growth beyond the original treatment fields, requiring enlargement of the treatment plan. One patient's treatment field was reduced after a decreased in cyst size. Cyst drainage was performed in another patient to avoid enlargement of the treatment fields. Conclusion: In patients undergoing highly conformal RT for craniopharyngiomas with cysts, routine imaging during treatment is recommended. Surveillance imaging should be performed at least every 2 weeks during proton RT in an attempt to avoid marginal failure. Craniopharyngiomas with large cystic components or enlargement during treatment might require weekly imaging.

  1. Energy Efficient Computing with the Low Power, Energy Aware Processing (LEAP) Architecture

    E-Print Network [OSTI]

    McIntire, Dustin Hale

    2012-01-01T23:59:59.000Z

    and communications module PWR RT618+RT620 Power module andwith a power supply module (PWR module), and a high fidelityAUX_BUS_CHAIN_OUT EMAP2 +MAG_PWR V5BUS V33BUS V9BUS -V9BUS

  2. Magnetic field contribution to the Lorentz model Kurt E. Oughstun

    E-Print Network [OSTI]

    Oughstun, Kurt

    Operations and Special Projects Division, U. S. Air Force Research Laboratory, Brooks City-Base, Texas 78235 appearing in the double brackets in any equation here is used as a conversion factor between cgs and MKS at the spacetime point r,t and where rj=rj r,t de- scribes the displacement of the electron from its equilib

  3. The Influence of Air-Conditioning Efficiency in the Peak Load Demand for Kuwait

    E-Print Network [OSTI]

    Ali, A. A.; Maheshwari, G. P.

    2007-01-01T23:59:59.000Z

    in reduction in peak load demand and savings of KD 2,301 million in capital expenditures are possible for the years between 2001 and 2025 if the PR of AC systems are improved to 1.2 kW/RT from its present level of 2.0 kW/RT. Also, it is estimated that extent...

  4. MachineIndependent Virtual Memory Management for Paged Uniprocessor and Multiprocessor Architectures

    E-Print Network [OSTI]

    uniprocessors and multiprocessors including the VAX family of uniprocessors and multiprocessors, the IBM RT PC paging support. Versions of Berkeley UNIX on non­VAX hardware, such as SunOS on the SUN 3 and ACIS 4.2 on the IBM RT PC, actually simulate internally the VAX memory mapping architecture ­­ in effect treating

  5. Chromium-Catalyzed Homoaldol Equivalent Reaction, Indium-Mediated Cycloisomerization, and Palladium-Catalyzed Cross-Coupling Reaction

    E-Print Network [OSTI]

    Kang, Jun

    2011-10-21T23:59:59.000Z

    , 0 ?C to rt, 15 h R OH OAc R OH OAc O SM productb a Reagents: VO(acac)2 (2 mol%), adducts 30 (1 mmol), TBHP (5.5 M solution) (2 mmol) in CH2Cl2 at rt for 15 h. b Isolated yield. c dr (syn:anti) was determined by 1H NMR spectroscopy...

  6. A survey of the customers of Fincastle Nursery and Farms

    E-Print Network [OSTI]

    Grant, Damon Gregory

    1986-01-01T23:59:59.000Z

    , Tyler, TX 75701 78. Mrs. J. C. Ray, 636 S Glenwod Blvd, Tyler, TX 75701 79. Jane Taylor, Rt 4, Box 5304, Athens, TX 75751 80. Ellis Thaxton, 1704 W Lovers Ln, Arlington, TX 76013 81. Bessie Scroggins, Rt 1, Box 1090, Elkhart, TX 75839 8 2. Betty...

  7. VISCOSITY OF AMORPHOUS SILICA WITHIN DOREMUS APPROACH Michael I. Ojovan, William E. Lee, Russell J. Hand*

    E-Print Network [OSTI]

    Sheffield, University of

    VISCOSITY OF AMORPHOUS SILICA WITHIN DOREMUS APPROACH Michael I. Ojovan, William E. Lee, Russell J flow is the two-exponential formula of the viscosity AT exp(B/RT)(1+C exp(D/RT)). Derived formula of viscosity has the Arrhenius-type behaviour in both high and low temperature limits and has a form similar

  8. Three Dimensional Radiative Transfer

    E-Print Network [OSTI]

    Tom Abel

    2000-05-09T23:59:59.000Z

    Radiative Transfer (RT) effects play a crucial role in the thermal history of the intergalactic medium. Here I discuss recent advances in the development of numerical methods that introduce RT to cosmological hydrodynamics. These methods can also readily be applied to time dependent problems on interstellar and galactic scales.

  9. Expression of PRL proteins at invasive margin of rectal cancers in relation to preoperative radiotherapy

    SciTech Connect (OSTI)

    Wallin, Asa R. [Department of Oncology, Institute of Biomedicine and Surgery, University of Linkoeping, Linkoeping (Sweden); Svanvik, Joar [Department of Surgery, Institute of Biomedicine and Surgery, University of Linkoeping, Linkoeping (Sweden); Adell, Gunnar [Department of Oncology, Institute of Biomedicine and Surgery, University of Linkoeping, Linkoeping (Sweden); Sun Xiaofeng [Department of Oncology, Institute of Biomedicine and Surgery, University of Linkoeping, Linkoeping (Sweden)]. E-mail: xiasu@ibk.liu.se

    2006-06-01T23:59:59.000Z

    Purpose: PRL-3 (phosphatase of regenerating liver) is involved in metastasis of colorectal cancer; however, its therapeutic implication in cancer patients has not been studied. We investigated the relationships of PRL expression to radiotherapy (RT) in rectal cancer patients. Methods and Materials: Phosphatase of regenerating liver expression was immunohistochemically examined in distant (n = 36) and adjacent (n = 82) normal mucosa, primary tumor (n = 125), biopsy specimens (n = 96), and lymph node metastasis (n = 30) from rectal cancer patients participating in a clinical trial of preoperative RT. Results: Phosphatase of regenerating liver expression was increased from the distant to adjacent mucosa and to the primary tumor (p < 0.05). PRL was highly expressed at the invasive margin in 28% of the primary tumors and 26% of the metastases. In the RT group, strong PRL expression at the invasive margin was related to distant recurrence (p 0.006) and poor survival (p = 0.01), but not in the non-RT group. The survival significance remained even after adjusting for Dukes' stage and differentiation (p = 0.02). Additional multivariate analyses showed that the correlation with prognostic significance of PRL differed between the RT and non-RT groups (p = 0.01). Conclusion: Phosphatase of regenerating liver expression (rather than PRL-3 alone) at the invasive margin predicted resistance to RT and unfavorable survival in rectal cancer patients with preoperative RT.

  10. GRAVITATIONALLY UNSTABLE FLAMES: RAYLEIGH-TAYLOR STRETCHING VERSUS TURBULENT WRINKLING

    SciTech Connect (OSTI)

    Hicks, E. P. [Center for Interdisciplinary Exploration and Research in Astrophysics (CIERA) and the Department of Physics and Astronomy, Northwestern University, Evanston, IL 60208 (United States); Rosner, R., E-mail: eph2001@columbia.edu [Computation Institute, University of Chicago, 5735 S. Ellis Ave., Chicago, IL 60637 (United States)

    2013-07-10T23:59:59.000Z

    In this paper, we provide support for the Rayleigh-Taylor-(RT)-based subgrid model used in full-star simulations of deflagrations in Type Ia supernovae explosions. We use the results of a parameter study of two-dimensional direct numerical simulations of an RT unstable model flame to distinguish between the two main types of subgrid models (RT or turbulence dominated) in the flamelet regime. First, we give scalings for the turbulent flame speed, the Reynolds number, the viscous scale, and the size of the burning region as the non-dimensional gravity (G) is varied. The flame speed is well predicted by an RT-based flame speed model. Next, the above scalings are used to calculate the Karlovitz number (Ka) and to discuss appropriate combustion regimes. No transition to thin reaction zones is seen at Ka = 1, although such a transition is expected by turbulence-dominated subgrid models. Finally, we confirm a basic physical premise of the RT subgrid model, namely, that the flame is fractal, and thus self-similar. By modeling the turbulent flame speed, we demonstrate that it is affected more by large-scale RT stretching than by small-scale turbulent wrinkling. In this way, the RT instability controls the flame directly from the large scales. Overall, these results support the RT subgrid model.

  11. Routing of IP Output Packets The UDP interface to the routing system

    E-Print Network [OSTI]

    Westall, James M.

    Routing of IP Output Packets The UDP interface to the routing system The RT_TOS macro retrieves the low order 5 bits from the tos field of the struct sock. These will be 0 unless set by setsockopt(). These include the DTRC bits and the low order bit is the ONLINK bit. #define RT_TOS(tos) ((tos)&IPTOS_TOS

  12. West Virginia University Institute of Technology Curriculum Matrix

    E-Print Network [OSTI]

    Mohaghegh, Shahab

    Health Services Administration BS 51.0701 Health Services Administration 013T History and Government BA Studies 03RT AOE Effective, Summer 2009 Government 04RT AOE Effective, Summer 2009 Health Care Services 05 Criminal Justice Administration ET07 Law and Legal Service Administration ET08 Non-Profit Administration ET

  13. West Virginia University Institute of Technology Curriculum Matrix

    E-Print Network [OSTI]

    Mohaghegh, Shahab

    Health Services Administration BS 51.0701 Health Services Administration 013T History and Government BA Administration ET06 Criminal Justice Administration ET07 Law and Legal Service Administration ET08 Non Cultural Studies 03RT AOE Effective, Summer 2009 Government 04RT AOE Effective, Summer 2009 Health Care

  14. SMART Camp 2013. Returning student application form Instructions

    E-Print Network [OSTI]

    Boas, Harold P.

    SMART Camp 2013. Returning student application form Instructions: Print out and complete clearly-mail (please, print clearly): 3. Home mailing address: 4. Phone number: 5. Gender (M/F): 6. Names of parents participated in since the previous SMaRT camp? What do you expect from spending another term in SMaRT camp

  15. alkaline gel electrophoresis: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to 1L Adjust pH to 8.3 with NaOH or acetic acid Store at RT TBE (5X) Tris 54g EDTA 4.65g Boric Acid 24g ddH2O up to 1L Adjust pH to 8.3 with boric acid Store at RT - Ethidium...

  16. agarose gel surrounding: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to 1L Adjust pH to 8.3 with NaOH or acetic acid Store at RT TBE (5X) Tris 54g EDTA 4.65g Boric Acid 24g ddH2O up to 1L Adjust pH to 8.3 with boric acid Store at RT - Ethidium...

  17. aminating reagents forthe: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to 1L Adjust pH to 8.3 with NaOH or acetic acid Store at RT TBE (5X) Tris 54g EDTA 4.65g Boric Acid 24g ddH2O up to 1L Adjust pH to 8.3 with boric acid Store at RT - Ethidium...

  18. Two New Approaches to Massive MIMO Ralf R. Mller

    E-Print Network [OSTI]

    Mller, Ralf R.

    antennas and R receive antennas, even for a static channel, RT channel coefficients must be estimated antennas, even for a static channel, RT channel coefficients must be estimated. With linear channel becomes significant. Standard approaches require one linear amplifier and mixer per transmit antenna. RF

  19. ZD6474, an inhibitor of VEGFR and EGFR tyrosine kinase activity in combination with radiotherapy

    SciTech Connect (OSTI)

    Frederick, Barbara [Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO (United States); Gustafson, Dan [Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO (United States); Bianco, Cataldo [Dipartimento di Oncologia, dei Trapianti e delle Nuove Technologie in Medicina, Universita di Pisa, Pisa (Italy); Ciardiello, Fortunato [Department of Molecular and Clinical Endocrinology, Universita degli Studi di Napoli Federico II, Naples (Italy); Dimery, Isaiah [AstraZeneca, Wilmington, DE (United States); Raben, David [Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO (United States)]. E-mail: david.raben@uchsc.edu

    2006-01-01T23:59:59.000Z

    Radiation enhances both epithelial growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) expression, which are a part of key pathways for tumor progression. Some tumors may not respond well to EGFR inhibitors alone or may develop resistance to EGFR inhibitors. Therefore, drug therapy targeted to VEGF receptors and EGFRs, when combined with radiotherapy (RT), may improve tumor control and provide wider applicability. This article focuses on ZD6474, an inhibitor of EGFR and VEGF receptor signaling in combination with RT. We discuss preclinical and clinical studies with RT and inhibitors of VEGF or EGFR signaling first. We then address issues associated with ZD6474 pharmacokinetic dosing, and scheduling when combined with RT. We also discuss ZD6474 in the context of anti-EGFR therapy resistance. Dual inhibition of EGFR and VEGF receptor signaling pathways shows promise in enhancing RT efficacy.

  20. Favorable Prognosis in Patients With High-Grade Glioma With Radiation Necrosis: The University of Colorado Reoperation Series

    SciTech Connect (OSTI)

    Rusthoven, Kyle E.; Olsen, Christine [Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO (United States); Franklin, Wilbur; Kleinschmidt-DeMasters, B.K. [Department of Pathology, University of Colorado School of Medicine, Aurora, CO (United States); Kavanagh, Brian D.; Gaspar, Laurie E. [Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO (United States); Lillehei, Kevin; Waziri, Allen [Department of Neurosurgery, University of Colorado School of Medicine, Aurora, CO (United States); Damek, Denise M. [Department of Neurology, University of Colorado School of Medicine, Aurora, CO (United States); Chen, Changhu, E-mail: changhu.chen@ucdenver.edu [Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO (United States)

    2011-09-01T23:59:59.000Z

    Purpose: To analyze the pathology, outcomes, and prognostic factors in patients with high-grade glioma undergoing reoperation after radiotherapy (RT). Methods and Materials: Fifty-one patients with World Health Organization Grade 3-4 glioma underwent reoperation after prior RT. The median dose of prior RT was 60 Gy, and 84% received chemotherapy as part of their initial treatment. Estimation of the percentage of necrosis and recurrent tumor in each reoperation specimen was performed. Pathology was classified as RT necrosis if {>=}80% of the specimen was necrotic and as tumor recurrence if {>=}20% was tumor. Predictors of survival were analyzed using log-rank comparisons and Cox proportional hazards regression. Results: The median interval between the completion of RT and reoperation was 6.7 months (range, 1-59 months). Pathologic analysis showed RT necrosis in 27% and recurrence in 73% of cases. Thirteen patients required a reoperation for uncontrolled symptoms. Among them, 1 patient (8%) had pathology showing RT necrosis, and 12 (92%) had tumor recurrence. Median survival after reoperation was longer for patients with RT necrosis (21.8 months vs. 7.0 months, p = 0.047). In 7 patients with Grade 4 tumors treated with temozolomide-based chemoradiation with RT necrosis, median survival from diagnosis and reoperation were 30.2 months and 21.8 months, respectively. Conclusions: Patients with RT necrosis at reoperation have improved survival compared with patients with tumor recurrence. Future efforts to intensify local therapy and increase local tumor control in patients with high-grade glioma seem warranted.

  1. A Score Predicting Posttreatment Ambulatory Status in Patients Irradiated for Metastatic Spinal Cord Compression

    SciTech Connect (OSTI)

    Rades, Dirk [Department of Radiation Oncology, University Hospital Schleswig-Holstein, Luebeck (Germany); Department of Radiation Oncology, Saad Specialist Hospital, Al Khobar (Saudi Arabia)], E-mail: Rades.Dirk@gmx.net; Rudat, Volker [Department of Radiation Oncology, Saad Specialist Hospital, Al Khobar (Saudi Arabia); Department of Radiation Oncology, University Medical Center Hamburg, Eppendorf (Germany); Veninga, Theo [Department of Radiotherapy, Dr. Bernard Verbeeten Institute, Tilburg (Netherlands); Stalpers, Lukas J.A. [Department of Radiotherapy, Academic Medical Center, Amsterdam (Netherlands); Basic, Hiba [Department of Radiation Oncology, University Hospital Sarajevo, Sarajevo (Bosnia and Herzegowina); Karstens, Johann H. [Department of Radiation Oncology, Medical School Hannover, Hannover (Germany); Hoskin, Peter J. [Department of Clinical Oncology, Mount Vernon Cancer Center, Northwood (United Kingdom); Schild, Steven E. [Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ (United States)

    2008-11-01T23:59:59.000Z

    Purpose: To create a scoring system to predict ambulatory status after radiotherapy (RT) for metastatic spinal cord compression (MSCC). Methods and Materials: On the basis of a multivariate analysis of 2096 MSCC patients, a scoring system was developed. This included the five prognostic factors significantly associated with post-RT ambulatory status: primary tumor type, interval between tumor diagnosis and MSCC, visceral metastases, motor function before RT, and time developing motor deficits before RT. The score for each factor was determined by dividing the post-RT ambulatory rate (as a percentage) by 10. Total scores represented the sum of the scores for each factor and ranged between 21 and 44 points. Patients were divided into five groups according to this score. Results: The post-RT ambulatory rates were 6% (24 of 389) for patients with scores of {<=}28 points, 44% (121 of 278) for those with 29-31 points, 70% (212 of 303) for those with 32-34 points, 86% (315 of 266) for those with 35-37 points, and 99% (750 of 760) for those with {>=}38 points. The 3-month survival rates were 29%, 62%, 77%, 84%, and 98%, respectively. The 6-months survival rates were 6%, 31%, 42%, 61%, and 93%, respectively. Conclusions: Because patients with scores of {<=}28 points had poor functional outcome after RT and extraordinarily poor survival rates, short-course RT to decrease pain or best supportive care may be considered. Patients with scores of 29-37 points should be considered surgical candidates, because RT-alone results were not optimal. Patients with scores of {>=}38 points seem to have excellent results with RT alone.

  2. Short-course radiotherapy is not optimal for spinal cord compression due to myeloma

    SciTech Connect (OSTI)

    Rades, Dirk [Department of Radiation Oncology, University Hospital, Hamburg (Germany) and Department of Radiation Oncology, Medical School, Hannover (Germany)]. E-mail: Rades.Dirk@gmx.net; Hoskin, Peter J. [Mount Vernon Centre for Cancer Treatment, Northwood, Middlesex (United Kingdom); Stalpers, Lukas J.A. [Department of Radiotherapy, Academic Medical Center, Amsterdam (Netherlands); Schulte, Rainer [Department of Radiation Oncology, University Hospital, Lubeck (Germany); Poortmans, Philip [Department of Radiation Oncology, Dr. Bernard Verbeeten Institute, Tilburg (Netherlands); Veninga, Theo [Department of Radiation Oncology, Dr. Bernard Verbeeten Institute, Tilburg (Netherlands); Dahm-Daphi, Jochen [Institute of Radiobiology, University Hospital Eppendorf, Hamburg (Germany); Obralic, Nermina [Department of Radiotherapy, University Hospital, Sarajevo (Bosnia and Herzegowina); Wildfang, Ingeborg [Department of Radiotherapy, Siloah Hospital, Hannover (Germany); Bahrehmand, Roja [Department of Radiotherapy, St. Georg Hospital, Hamburg (Germany); Engenhart-Cabilic, Rita [Department of Radiation Oncology, Philipps-University, Marburg (Germany); Schild, Steven E. [Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ (United States)

    2006-04-01T23:59:59.000Z

    Purpose: To investigate the suitability of short-course radiotherapy (RT) for spinal cord compression (SCC) in myeloma patients. Methods and Materials: Data for 172 myeloma patients irradiated between January 1994 and December 2004 for SCC were retrospectively evaluated. Short-course RT (1 x 8 Gy, 5 x 4 Gy, n = 61) and long-course RT (10 x 3 Gy, 15 x 2.5 Gy, 20 x 2 Gy, n = 111) were compared for functional outcome up to 24 months after RT. In addition, 10 potential prognostic factors were investigated. Results: Improvement of motor function occurred in 90 patients (52%). Forty-seven percent of nonambulatory patients regained the ability to walk. Functional outcome was significantly influenced by the time of developing motor deficits before RT. Improvement of motor function was more frequent after long-course RT than after short-course RT: 59% vs. 39% (p = 0.10) at 1 month, 67% vs. 43% (p 0.043) at 6 months, 76% vs. 40% (p = 0.003) at 12 months, 78% vs. 43% (p 0.07) at 18 months, and 83% v 54% (p = 0.33) at 24 months. A subgroup analysis of the long-course RT group demonstrated a similar functional outcome for 10 x 3 Gy when compared with 15 x 2.5 Gy and 20 x 2 Gy. Conclusions: Long-course RT is preferable for SCC in myeloma patients because it resulted in better functional outcome than short-course RT. Treatment with 10 x 3 Gy can be considered appropriate.

  3. Whole-pelvis, 'mini-pelvis,' or prostate-only external beam radiotherapy after neoadjuvant and concurrent hormonal therapy in patients treated in Radiation Therapy Oncology Group 9413 trial

    SciTech Connect (OSTI)

    Roach, Mack [University of California San Francisco, San Francisco, CA (United States)]. E-mail: roach@radonc17.ucsf.edu; De Silvio, Michelle [RTOG Statistical Headquarters, Philadelphia, PA (United States); Valicenti, Richard [Thomas Jefferson University, Philadelphia, PA (United States); Grignon, David [Wayne State University, Detroit, MI (United States); Asbell, Sucha O. [Albert Einstein Medical Center, Philadelphia, PA (United States); Lawton, Colleen [Medical College of Wisconsin, Milwaukee, WI (United States); Thomas, Charles R. [Oregon Health and Sciences University, Portland OR (United States); Shipley, William U. [Massachusetts General Hospital, Boston, MA (United States)

    2006-11-01T23:59:59.000Z

    Purpose: Radiation Therapy Oncology Group (RTOG) 9413 trial demonstrated a better progression-free survival (PFS) with whole-pelvis (WP) radiotherapy (RT) compared with prostate-only (PO) RT. This secondary analysis was undertaken to determine whether 'mini-pelvis' (MP; defined as {>=}10 x 11 cm but <11 x 11 cm) RT resulted in progression-free survival (PFS) comparable to that of WP RT. To avoid a timing bias, this analysis was limited to patients receiving neoadjuvant and concurrent hormonal therapy (N and CHT) in Arms 1 and 2 of the study. Methods and Materials: Eligible patients had a risk of lymph node (LN) involvement >15%. Neoadjuvant and concurrent hormonal therapy (N and CHT) was administered 2 months before and during RT for 4 months. From April 1, 1995, to June 1, 1999, a group of 325 patients were randomized to WP RT + N and CHT and another group of 324 patients were randomized to receive PO RT + N and CHT. Patients randomized to PO RT were dichotomized by median field size (10 x 11 cm), with the larger field considered an 'MP' field and the smaller a PO field. Results: The median PFS was 5.2, 3.7, and 2.9 years for WP, MP, and PO fields, respectively (p = 0.02). The 7-year PFS was 40%, 35%, and 27% for patients treated to WP, MP, and PO fields, respectively. There was no association between field size and late Grade 3+ genitourinary toxicity but late Grade 3+ gastrointestinal RT complications correlated with increasing field size. Conclusions: This subset analysis demonstrates that RT field size has a major impact on PFS, and the findings support comprehensive nodal treatment in patients with a risk of LN involvement of >15%.

  4. Radiotherapy to Improve Local Control Regardless of Surgical Margin and Malignancy Grade in Extremity and Trunk Wall Soft Tissue Sarcoma: A Scandinavian Sarcoma Group Study

    SciTech Connect (OSTI)

    Jebsen, Nina L. [Department of Surgical Sciences, University of Bergen Faculty of Medicine, Bergen (Norway); Department of Oncology, Haukeland University Hospital, Bergen (Norway)], E-mail: njeb@helse-bergen.no; Trovik, Clement S. [Department of Oncology, Haukeland University Hospital, Bergen (Norway); Department of Orthopedics, Haukeland University Hospital, Bergen (Norway); Bauer, Henrik C.F. [Department of Orthopedics, Karolinska Hospital, Stockholm (Sweden); Rydholm, Anders [Department of Orthopedics, Lund University Hospital, Lund (Sweden); Monge, Odd R. [Department of Oncology, Haukeland University Hospital, Bergen (Norway); Hall, Kirsten Sundby [Cancer Clinic, Rikshospitalet-Radiumhospitalet Medical Center, Oslo (Norway); Alvegard, Thor [Department of Cancer Epidemiology, Lund University Hospital, Lund (Sweden); Bruland, Oyvind S. [Cancer Clinic, Rikshospitalet-Radiumhospitalet Medical Center, Oslo (Norway); University of Oslo, Faculty Group, Norwegian Radium Hospital, Oslo (Norway)

    2008-07-15T23:59:59.000Z

    Purpose: Adjuvant radiotherapy has during the past decades become increasingly used in the treatment of localized soft tissue sarcoma. We evaluated the effect of radiotherapy (RT) on local recurrence rates (LRRs) in Scandinavia between 1986 and 2005. Methods and Materials: A total of 1,093 adult patients with extremity or trunk wall soft tissue sarcoma treated at four Scandinavian sarcoma centers were stratified according to the treatment period (1986-1991, 1992-1997, and 1998-2005). The use of adjuvant RT, quality of the surgical margin, interval between surgery and RT, and LRR were analyzed. The median follow-up was 5 years. Results: The use of RT (77% treated postoperatively) increased from 28% to 53%, and the 5-year LRR decreased from 27% to 15%. The rate of wide surgical margins did not increase. The risk factors for local recurrence were histologic high-grade malignancy (hazard ratio [HR], 5), an intralesional (HR, 6) or marginal (HR, 3) surgical margin, and no RT (HR, 3). The effect of RT on the LRR was also significant after a wide margin resection and in low-grade malignant tumors. The LRR was the same after preoperative and postoperative RT. The median interval from surgery to the start of RT was 7 weeks, and 98% started RT within 4 months. The LRR was the same in patients who started treatment before and after 7 weeks. Conclusion: The results of our study have shown that adjuvant RT effectively prevents local recurrence in soft tissue sarcoma, irrespective of the tumor depth, malignancy grade, and surgical margin status. The effect was most pronounced in deep-seated, high-grade tumors, even when removed with a wide surgical margin.

  5. Correlating Computed Tomography Perfusion Changes in the Pharyngeal Constrictor Muscles During Head-and-Neck Radiotherapy to Dysphagia Outcome

    SciTech Connect (OSTI)

    Truong, Minh Tam, E-mail: mitruong@bu.edu [Department of Radiation Oncology, Boston Medical Center and Boston University School of Medicine, Boston, MA (United States); Department of Radiology, Boston Medical Center and Boston University School of Medicine, Boston, MA (United States); Lee, Richard [Department of Radiation Oncology, Boston Medical Center and Boston University School of Medicine, Boston, MA (United States); Saito, Naoko [Department of Radiology, Boston Medical Center and Boston University School of Medicine, Boston, MA (United States); Qureshi, Muhammad M. [Department of Radiation Oncology, Boston Medical Center and Boston University School of Medicine, Boston, MA (United States); Ozonoff, Al [Department of Biostatistics, Boston University School of Public Health, Boston, MA (United States); Romesser, Paul B. [Department of Radiation Oncology, Boston Medical Center and Boston University School of Medicine, Boston, MA (United States); Wang, Jimmy; Sakai, Osamu [Department of Radiology, Boston Medical Center and Boston University School of Medicine, Boston, MA (United States)

    2012-02-01T23:59:59.000Z

    Purpose: To measure changes in perfusion of the pharyngeal constrictor muscles (PCM) using CT perfusion (CTP) imaging during a course of definitive radiotherapy (RT) in head-and-neck cancer (HNC) patients and correlate with dysphagia outcome after RT. Methods and Materials: Fifteen HNC patients underwent CTP imaging of the PCM at baseline and Weeks 2, 4, and 6 during RT and 6 weeks after RT. Blood flow and blood volume were measured in the PCM, and percentage change from baseline scan was determined. A single physician-based assessment of dysphagia was performed every 3 months after RT using the Common Terminology Criteria for Adverse Events, version 3.0 grading system. Results: With a median follow-up of 28 months (range, 6-44 months), Grade 3 dysphagia was present in 7 of 15 patients, and 8 patients experienced Grade 0-2 dysphagia. The CTP parameters at Week 2 of RT demonstrated an increase in mean PCM blood flow of 161.9% vs. 12.3% (p = 0.007) and an increase in mean PCM blood volume of 96.6% vs. 8.7% (p = 0.039) in patients with 6-month post-RT Grade 3 dysphagia and Grade 0-2 dysphagia, respectively. On multivariate analysis, when adjusting for smoking history, tumor volume, and baseline dysphagia status, an increase in blood flow in the second week of RT was significant for 3- and 6-month Grade 3 dysphagia (p < 0.05). Conclusions: Perfusion changes in the PCM during Week 2 of RT in the PCM may predict the severity of dysphagia after HNC RT.

  6. Technological Advancements and Error Rates in Radiation Therapy Delivery

    SciTech Connect (OSTI)

    Margalit, Danielle N., E-mail: dmargalit@partners.org [Harvard Radiation Oncology Program, Boston, MA (United States); Harvard Cancer Consortium and Brigham and Women's Hospital/Dana Farber Cancer Institute, Boston, MA (United States); Chen, Yu-Hui; Catalano, Paul J.; Heckman, Kenneth; Vivenzio, Todd; Nissen, Kristopher; Wolfsberger, Luciant D.; Cormack, Robert A.; Mauch, Peter; Ng, Andrea K. [Harvard Cancer Consortium and Brigham and Women's Hospital/Dana Farber Cancer Institute, Boston, MA (United States)

    2011-11-15T23:59:59.000Z

    Purpose: Technological advances in radiation therapy (RT) delivery have the potential to reduce errors via increased automation and built-in quality assurance (QA) safeguards, yet may also introduce new types of errors. Intensity-modulated RT (IMRT) is an increasingly used technology that is more technically complex than three-dimensional (3D)-conformal RT and conventional RT. We determined the rate of reported errors in RT delivery among IMRT and 3D/conventional RT treatments and characterized the errors associated with the respective techniques to improve existing QA processes. Methods and Materials: All errors in external beam RT delivery were prospectively recorded via a nonpunitive error-reporting system at Brigham and Women's Hospital/Dana Farber Cancer Institute. Errors are defined as any unplanned deviation from the intended RT treatment and are reviewed during monthly departmental quality improvement meetings. We analyzed all reported errors since the routine use of IMRT in our department, from January 2004 to July 2009. Fisher's exact test was used to determine the association between treatment technique (IMRT vs. 3D/conventional) and specific error types. Effect estimates were computed using logistic regression. Results: There were 155 errors in RT delivery among 241,546 fractions (0.06%), and none were clinically significant. IMRT was commonly associated with errors in machine parameters (nine of 19 errors) and data entry and interpretation (six of 19 errors). IMRT was associated with a lower rate of reported errors compared with 3D/conventional RT (0.03% vs. 0.07%, p = 0.001) and specifically fewer accessory errors (odds ratio, 0.11; 95% confidence interval, 0.01-0.78) and setup errors (odds ratio, 0.24; 95% confidence interval, 0.08-0.79). Conclusions: The rate of errors in RT delivery is low. The types of errors differ significantly between IMRT and 3D/conventional RT, suggesting that QA processes must be uniquely adapted for each technique. There was a lower error rate with IMRT compared with 3D/conventional RT, highlighting the need for sustained vigilance against errors common to more traditional treatment techniques.

  7. Patterns of Practice of Palliative Radiotherapy in Africa, Part 1: Bone and Brain Metastases

    SciTech Connect (OSTI)

    Sharma, Vinay [Johannesburg Hospital, University of Witwatersrand, Johannesburg (South Africa)], E-mail: sharmav@medicine.wits.ac.za; Gaye, Papa Macoumba M.Med. [Institut Curie, Hopital Aristide le Dentec, Univesite Cheikh Anta Diop de Dakar, Dakar (Senegal); Wahab, Sherif Abdel [Ain Shams University, Abbasia, Cairo (Egypt); Ndlovu, Ntokozo [Medical School, Radiotherapy Centre, Harare (Zimbabwe); Ngoma, Twalib [Ocean Road Hospital, Ocean Road Cancer Institute, Dar Es Salaam (Tanzania); Vanderpuye, Verna [Korle Bu Teaching Hospital, Accra (Ghana); Sowunmi, Anthonia [Teaching Hospital, University of Lagos, Surulere, Lagos (Nigeria); Kigula-Mugambe, Joseph [Radiotherapy Department, Makerere University, Kampala (Uganda); Jeremic, Branislav [International Atomic Energy Agency, Vienna (Austria)

    2008-03-15T23:59:59.000Z

    Purpose: To provide data on the pattern of practice of palliative radiotherapy (RT) on the African continent. Methods and Materials: A questionnaire was distributed to participants in a regional training course of the International Atomic Energy Agency in palliative cancer care and sent by e-mail to other institutions in Africa. Requested information included both infrastructure and human resources available and the pattern of RT practice for metastatic and locally advanced cancers. Results: Of 35 centers contacted, 24 (68%) completed the questionnaire. Although RT is used by most centers for most metastatic cancers, liver and lung metastases are treated with chemotherapy. Of 23 centers, 14 (61%) had a single RT regimen as an institutional policy for treating painful bone metastases, but only 5 centers (23%) of 23 used 8 Gy in 1 fraction. Brain metastases were being treated by RT to the whole brain to 30 Gy in 10 fractions, either exclusively (n = 13, 56%) or in addition to the use of 20 Gy in 5 fractions (n = 3, 14%). Conclusion: Radiotherapy is a major component of treatment of cancer patients in African countries. There is consensus among few centers for treatment schedules for almost all sites regarding time and dose-fractionation characteristics of RT regimens used and/or indications for the use of RT in this setting.

  8. Does Quality of Radiation Therapy Predict Outcomes of Multicenter Cooperative Group Trials? A Literature Review

    SciTech Connect (OSTI)

    Fairchild, Alysa, E-mail: alysa.fairchild@albertahealthservices.ca [Department of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta (Canada); Straube, William [Advanced Technology Consortium, Imaged-Guided Therapy QA Center, St. Louis, Missouri (United States); Laurie, Fran [Quality Assurance Review Center, Lincoln, Rhode Island (United States); Followill, David [Radiological Physics Center, University of Texas MD Anderson Cancer Centre, Houston, Texas (United States)

    2013-10-01T23:59:59.000Z

    Central review of radiation therapy (RT) delivery within multicenter clinical trials was initiated in the early 1970s in the United States. Early quality assurance publications often focused on metrics related to process, logistics, and timing. Our objective was to review the available evidence supporting correlation of RT quality with clinical outcomes within cooperative group trials. A MEDLINE search was performed to identify multicenter studies that described central subjective assessment of RT protocol compliance (quality). Data abstracted included method of central review, definition of deviations, and clinical outcomes. Seventeen multicenter studies (1980-2012) were identified, plus one Patterns of Care Study. Disease sites were hematologic, head and neck, lung, breast, and pancreas. Between 0 and 97% of treatment plans received an overall grade of acceptable. In 7 trials, failure rates were significantly higher after inadequate versus adequate RT. Five of 9 and 2 of 5 trials reported significantly worse overall and progression-free survival after poor-quality RT, respectively. One reported a significant correlation, and 2 reported nonsignificant trends toward increased toxicity with noncompliant RT. Although more data are required, protocol-compliant RT may decrease failure rates and increase overall survival and likely contributes to the ability of collected data to answer the central trial question.

  9. Proton Therapy for Breast Cancer After Mastectomy: Early Outcomes of a Prospective Clinical Trial

    SciTech Connect (OSTI)

    MacDonald, Shannon M., E-mail: smacdonald@partners.org [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States); Patel, Sagar A.; Hickey, Shea [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States)] [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States); Specht, Michelle [Department of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States)] [Department of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States); Isakoff, Steven J. [Division of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States)] [Division of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States); Gadd, Michele; Smith, Barbara L. [Department of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States)] [Department of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States); Yeap, Beow Y. [Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States)] [Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States); Adams, Judith; DeLaney, Thomas F.; Kooy, Hanne; Lu, Hsiao-Ming; Taghian, Alphonse G. [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States)] [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States)

    2013-07-01T23:59:59.000Z

    Purpose: Dosimetric planning studies have described potential benefits for the use of proton radiation therapy (RT) for locally advanced breast cancer. We report acute toxicities and feasibility of proton delivery for 12 women treated with postmastectomy proton radiation with or without reconstruction. Methods and Materials: Twelve patients were enrolled in an institutional review board-approved prospective clinical trial. The patients were assessed for skin toxicity, fatigue, and radiation pneumonitis during treatment and at 4 and 8 weeks after the completion of therapy. All patients consented to have photographs taken for documentation of skin toxicity. Results: Eleven of 12 patients had left-sided breast cancer. One patient was treated for right-sided breast cancer with bilateral implants. Five women had permanent implants at the time of RT, and 7 did not have immediate reconstruction. All patients completed proton RT to a dose of 50.4 Gy (relative biological effectiveness [RBE]) to the chest wall and 45 to 50.4 Gy (RBE) to the regional lymphatics. No photon or electron component was used. The maximum skin toxicity during radiation was grade 2, according to the Common Terminology Criteria for Adverse Events (CTCAE). The maximum CTCAE fatigue was grade 3. There have been no cases of RT pneumonitis to date. Conclusions: Proton RT for postmastectomy RT is feasible and well tolerated. This treatment may be warranted for selected patients with unfavorable cardiac anatomy, immediate reconstruction, or both that otherwise limits optimal RT delivery using standard methods.

  10. Rayleigh-Taylor Unstable Flames -- Fast or Faster?

    E-Print Network [OSTI]

    Hicks, E P

    2015-01-01T23:59:59.000Z

    Rayleigh-Taylor (RT) unstable flames play a key role in the explosions of Type Ia supernovae. However, the dynamics of these flames is still not well-understood. RT unstable flames are affected by both the RT instability of the flame front and by RT-generated turbulence. The coexistence of these factors complicates the choice of flame speed subgrid models for full-star Type Ia simulations. Both processes can stretch and wrinkle the flame surface, increasing its area and, therefore, the burning rate. In past research, subgrid models have been based on either the RT instability or turbulence setting the flame speed. We evaluate both models, checking their assumptions and their ability to correctly predict the turbulent flame speed. Specifically, we analyze a large parameter study of 3D direct numerical simulations of RT unstable model flames. This study varies both the simulation domain width and the gravity in order to probe a wide range of flame behaviors. We show that RT unstable flames are different from tr...

  11. Combination of Vessel-Targeting Agents and Fractionated Radiation Therapy: The Role of the SDF-1/CXCR4 Pathway

    SciTech Connect (OSTI)

    Chen, Fang-Hsin; Fu, Sheng-Yung [Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan (China)] [Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan (China); Yang, Ying-Chieh [Department of Radiation Oncology, National Taiwan University Hospital Hsin-Chu Branch, Taiwan (China)] [Department of Radiation Oncology, National Taiwan University Hospital Hsin-Chu Branch, Taiwan (China); Wang, Chun-Chieh [Department of Radiation Oncology, Chang Gung Memorial Hospital-LinKou, Taiwan (China) [Department of Radiation Oncology, Chang Gung Memorial Hospital-LinKou, Taiwan (China); Department of Medical Imaging and Radiological Science, Chang Gung University, Taiwan (China); Chiang, Chi-Shiun, E-mail: cschiang@mx.nthu.edu.tw [Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan (China)] [Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan (China); Hong, Ji-Hong, E-mail: jihong@adm.cgmh.org.tw [Department of Radiation Oncology, Chang Gung Memorial Hospital-LinKou, Taiwan (China) [Department of Radiation Oncology, Chang Gung Memorial Hospital-LinKou, Taiwan (China); Department of Medical Imaging and Radiological Science, Chang Gung University, Taiwan (China)

    2013-07-15T23:59:59.000Z

    Purpose: To investigate vascular responses during fractionated radiation therapy (F-RT) and the effects of targeting pericytes or bone marrow-derived cells (BMDCs) on the efficacy of F-RT. Methods and Materials: Murine prostate TRAMP-C1 tumors were grown in control mice or mice transplanted with green fluorescent protein-tagged bone marrow (GFP-BM), and irradiated with 60 Gy in 15 fractions. Mice were also treated with gefitinib (an epidermal growth factor receptor inhibitor) or AMD3100 (a CXCR4 antagonist) to examine the effects of combination treatment. The responses of tumor vasculatures to these treatments and changes of tumor microenvironment were assessed. Results: After F-RT, the tumor microvascular density (MVD) was reduced; however, the surviving vessels were dilated, incorporated with GFP-positive cells, tightly adhered to pericytes, and well perfused with Hoechst 33342, suggesting a more mature structure formed primarily via vasculogenesis. Although the gefitinib+F-RT combination affected the vascular structure by dissociating pericytes from the vascular wall, it did not further delay tumor growth. These tumors had higher MVD and better vascular perfusion function, leading to less hypoxia and tumor necrosis. By contrast, the AMD3100+F-RT combination significantly enhanced tumor growth delay more than F-RT alone, and these tumors had lower MVD and poorer vascular perfusion function, resulting in increased hypoxia. These tumor vessels were rarely covered by pericytes and free of GFP-positive cells. Conclusions: Vasculogenesis is a major mechanism for tumor vessel survival during F-RT. Complex interactions occur between vessel-targeting agents and F-RT, and a synergistic effect may not always exist. To enhance F-RT, using CXCR4 inhibitor to block BM cell influx and the vasculogenesis process is a better strategy than targeting pericytes by epidermal growth factor receptor inhibitor.

  12. Postoperative Radiation Therapy With or Without Concurrent Chemotherapy for Node-Positive Thoracic Esophageal Squamous Cell Carcinoma

    SciTech Connect (OSTI)

    Chen, Junqiang; Pan, Jianji [Department of Radiation Oncology, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China)] [Department of Radiation Oncology, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China); Liu, Jian, E-mail: liujianfj@yahoo.com.cn [Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fuzhou (China)] [Department of Medical Oncology, Fujian Provincial Cancer Hospital, Fuzhou (China); Li, Jiancheng [Department of Radiation Oncology, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China)] [Department of Radiation Oncology, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China); Zhu, Kunshou [Department of Surgery, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China)] [Department of Surgery, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China); Zheng, Xiongwei [Department of Pathology, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China)] [Department of Pathology, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China); Chen, Mingqiang [Department of Radiation Oncology, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China)] [Department of Radiation Oncology, Teaching Hospital of Fujian Medical University, Fujian Provincial Cancer Hospital, Fuzhou (China); Chen, Ming [School of Graduate, Fujian University of Traditional Chinese Medicine, Fuzhou (China)] [School of Graduate, Fujian University of Traditional Chinese Medicine, Fuzhou (China); Liao, Zhongxing [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-07-15T23:59:59.000Z

    Purpose: To retrospectively compare the efficacy of radiation therapy (RT) and chemotherapy plus RT (CRT) for the postoperative treatment of node-positive thoracic esophageal squamous cell carcinoma (TESCC) and to determine the incidence and severity of toxic reactions. Methods and Materials: We retrospectively reviewed data from 304 patients who had undergone esophagectomy with 3-field lymph node dissection for TESCC and were determined by postoperative pathology to have lymph node metastasis without distant hematogenous metastasis. Of these patients, 164 underwent postoperative chemotherapy (cisplatin 80 mg/m{sup 2}, average days 1-3, plus paclitaxel 135 mg/m{sup 2}, day 1; 21-day cycle) plus RT (50 Gy), and 140 underwent postoperative RT alone. Results: The 5-year overall survival rates for the CRT and RT groups were 47.4% and 38.6%, respectively (P=.030). The distant metastasis rate, the mixed (regional lymph node and distant) metastasis rate, and the overall recurrence rate were significantly lower in the CRT group than in the RT group (P<.05). However, mild and severe early toxic reactions, including neutropenia, radiation esophagitis, and gastrointestinal reaction, were significantly more common in the CRT group than in the RT group (P<.05). No significant differences in incidence of late toxic reactions were found between the 2 groups. Conclusions: Our results show that in node-positive TESCC patients, postoperative CRT is significantly more effective than RT alone at increasing the overall survival and decreasing the rates of distant metastasis, mixed metastasis, and overall recurrence. Severe early toxic reactions were more common with CRT than with RT alone, but patients could tolerate CRT.

  13. Radiotherapy for Liver Metastases: A Review of Evidence

    SciTech Connect (OSTI)

    Hoyer, Morten, E-mail: hoyer@aarhus.rm.dk [Department of Oncology, Aarhus University Hospital, Aarhus (Denmark); Swaminath, Anand [Radiation Medicine Program, Princess Margaret Hospital, University of Toronto, Toronto, Ontario (Canada); Bydder, Sean [Radiation Oncology, Sir Charles Gairdner Hospital, Perth (Australia); Lock, Michael [Department of Oncology, University of Western Ontario, London, Ontario (Canada); Mendez Romero, Alejandra [Department of Radiation Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam (Netherlands); Kavanagh, Brian [Department of Radiation Oncology, University of Colorado Comprehensive Cancer Center, Aurora, CO (United States); Goodman, Karyn A. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Okunieff, Paul [Department of Radiation Oncology, University of Florida, Gainesville, FL (United States); Dawson, Laura A. [Radiation Medicine Program, Princess Margaret Hospital, University of Toronto, Toronto, Ontario (Canada)

    2012-03-01T23:59:59.000Z

    Over the past decade, there has been an increasing use of radiotherapy (RT) for the treatment of liver metastases. Most often, ablative doses are delivered to focal liver metastases with the goal of local control and ultimately improving survival. In contrast, low-dose whole-liver RT may be used for the palliation of symptomatic diffuse metastases. This review examines the available clinical data for both approaches. The review found that RT is effective both for local ablation of focal liver metastases and for palliation of patients with symptomatic liver metastases. However, there is a lack of a high level of evidence from randomized clinical trials.

  14. Evaluation of fuel rod characterization for transient fuel modeling

    E-Print Network [OSTI]

    Bechler, Eric Wayne

    1989-01-01T23:59:59.000Z

    P+ (g1+ g2) + brad (4) 17 where hgap is the gap conductance ks is the conductivity of the gas mixture tsap is the gap width gt+g2 are the temperature jump distances at the clad inner and fuel outer surfaces The temperature jump distances... the temperature of the fuel increases dramatically. & The model defines the total cumulative release during time t to be t 2 ) ( ) d ~ 1- exp[-m rt (r (t) - r(u))] m=1 m tt 0 (6) where rt r(t) = J D'(u) du 0 R is the total fission gas release during time...

  15. Structural transformations in Mn{sub 2}NiGa due to residual stress

    SciTech Connect (OSTI)

    Singh, Sanjay; Maniraj, M.; D'Souza, S. W.; Barman, S. R. [UGC-DAE Consortium for Scientific Research, Khandwa Road, Indore 452001 (India); Ranjan, R. [Department of Materials Engineering, Indian Institute of Science, Bangalore 560012 (India)

    2010-02-22T23:59:59.000Z

    Powder x-ray diffraction study of Mn{sub 2}NiGa ferromagnetic shape memory alloy shows the existence of a 7M monoclinic modulated structure at room temperature (RT). The structure of Mn{sub 2}NiGa is found to be highly dependent on residual stress. For higher stress, the structure is tetragonal at RT, and for intermediate stress it is 7M monoclinic. However, only when the stress is considerably relaxed, the structure is cubic, as is expected at RT since the martensitic transition temperature is 230 K.

  16. Capacitance-based prover for gas flow meters

    E-Print Network [OSTI]

    Pipkins, Sean Patrick

    1995-01-01T23:59:59.000Z

    ;?= enthalpy of the air at the inlet. H Uo =U +RT Uo =Cv(T To)+RT, (36) 24 Equation (35) can be written as c (T-T)=[c (T?? T)+RT. , ?] Il ? ' n j (37) Solving Equation (37) for T gives the equation used to calculate the temperature profiles of the air.... . . . . Relation of Capacitance Change to Molar Flow Rate. DiIferential Method Integral Method THEORETICAL CALCULATIONS. Calculated C. Experimental C. Thermal Expansion Effects . . Capacitance Change Due to Length Change Capacitance Change Due to Radius...

  17. On the Error in QR Integration

    E-Print Network [OSTI]

    Dieci, Luca; Van Vleck, Erik

    2008-03-07T23:59:59.000Z

    ] . . . [R(t2, t1) +E2][R(t1, t0) +E1]R(t0) , k = 1, 2, . . . , where Q(tk) is the exact Q-factor at tk and the triangular transitions R(tj , tj?1) are also the exact ones. Moreover, the factors Ej , j = 1, . . . , k, are bounded in norm by the local error... committed during integration of the relevant differential equations; see Theorems 3.1 and 3.16. We will henceforth simply write (2.7) ?Ej? ? ?, j = 1, 2, . . . , and stress that ? is computable, in fact controllable, in terms of local error tolerances...

  18. Radiative transfer in molecular lines

    E-Print Network [OSTI]

    A. Asensio Ramos; J. Trujillo Bueno; J. Cernicharo

    2001-02-15T23:59:59.000Z

    The highly convergent iterative methods developed by Trujillo Bueno and Fabiani Bendicho (1995) for radiative transfer (RT) applications are generalized to spherical symmetry with velocity fields. These RT methods are based on Jacobi, Gauss-Seidel (GS), and SOR iteration and they form the basis of a new NLTE multilevel transfer code for atomic and molecular lines. The benchmark tests carried out so far are presented and discussed. The main aim is to develop a number of powerful RT tools for the theoretical interpretation of molecular spectra.

  19. A. E. K. Ris Ris-M -CUE] Title and author(s)

    E-Print Network [OSTI]

    - tageous . Copies to Library 100 G.K. Kristiansen 1( RT 12 I Available on request from: Ris Library, are considered for 2-dimensional geometries xy, rz, and r6. There are 3 types of problems, 1) A 1/K

  20. How the augmented Lagrangian algorithm can deal with an ...

    E-Print Network [OSTI]

    2014-08-25T23:59:59.000Z

    Aug 23, 2014 ... ings of the 4th Conference of Probability, Brasov, Romania, pages 7381. 7. [47] R.T. Rockafellar (1973). A dual approach to solving nonlinear...

  1. forest Ecology Forest Ecology and ~1anagement 112 (1998) 41-47

    E-Print Network [OSTI]

    1998-01-01T23:59:59.000Z

    reserved. Pit, 50378-1 t27(98)n03 17-X #12;LM, I'WI Zy/ el a/.IFVrt'.H Eco/0K.v and MarlaRt'mem 1/2 (/998

  2. PHYSICAL REVIEW A 85, 043820 (2012) Absolute measurement of the transient optical nonlinearity in N2, O2, N2O, and Ar

    E-Print Network [OSTI]

    Milchberg, Howard

    2012-01-01T23:59:59.000Z

    harmonic generation and attosecond physics [1], femtosecond filamentation [2], and pulse compression [3 by a time-domain Raman response function R(t). The total nonlinear index of refraction, to second order

  3. IT Services Organisation Structure 21 June 2014

    E-Print Network [OSTI]

    Sussex, University of

    Manager: Adam Ford Head: Sandy Radford Head: Mike Luscombe Greg Austin Email and RT Millard Trainers (p/t) *1 ~0.1 FTE Kyle Fieldus Jeffrey Relf Research Support Kes

  4. U.S. Department

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    To:806 477 6256 o FEB 2 3 2010 c0 rt U.S. Department of Transportation Federal Motor 1200 New Jersey Ave .* S.E. Carrier Safety Washington, DC 20590 Administration...

  5. EINLADUNG INFOTAG 2001 Eine Forschungsanstalt

    E-Print Network [OSTI]

    Wehrli, Bernhard

    durch den Benzinzusatz MTBE. Methyl-tert-butylether gehört weltweit zu den meistproduzierten orga- nischen Chemikalien. Weil MTBE im Grundwasser auftritt, soll es in den USA als Benzinzusatz verboten

  6. Iatiku 02

    E-Print Network [OSTI]

    Ostler, Nicholas D M

    1996-01-01T23:59:59.000Z

    ................................................................................................ 2 ......................................................................................... Reports on Meetings 3, 4, 5 4 Conservation of Endangered Languages: Echoes of the Bristol Seminar .................................... 6 3 . Appeals... It's rt ......... ......................... .. .. ...... ......... ............. .. ..... . . . laces t . t e e a i t e rl ........ .... ......... ........... ..... ................. ... . .... .. ......... ......... I IA: a e lectronic...

  7. Report on the Software Environments Technical Research Review Jerey J. Blevins, E. James Whitehead, Jr., and Harry E. Yessayan

    E-Print Network [OSTI]

    Whitehead, James

    was on \\programming" rather than on software development. People built programming environments which essentially con, to support programmers. These environments, such as Interlisp [TM81], Unix [RT78], CPS [TR81], and Mentor

  8. The adsorption of water on Cu2O and Al2O3 thin films

    E-Print Network [OSTI]

    Deng, Xingyi

    2010-01-01T23:59:59.000Z

    since in equilibrium adsorption and desorption rates are theexp(-E a /RT), while the gas adsorption rate depends on theThe adsorption of water on Cu 2 O and Al 2 O 3 thin films

  9. The characterization, functional expression, and localization of the first arthropod myokinin receptor from the southern cattle tick, Boophilus microplus (Acari: ixodidae)

    E-Print Network [OSTI]

    Holmes, Steven P.

    2004-09-30T23:59:59.000Z

    the southern cattle tick, Boophilus microplus. The deduced amino acid sequence was 40 % identical to the lymnokinin receptor. The receptor transcript is present in all tick life stages as determined by semiquantitative RT-PCR. When expressed in mammalian CHO...

  10. NV: ELTE AZONOST: Mat. BSc. Algebra2: 4. vizsga (keresztflv)/1 2010. jan. 26.

    E-Print Network [OSTI]

    Kiss, Emil

    . Számítsuk ki a kvaterniócsoportban (kjk)2009 k-2 értékét. (kjk)2009 k-2 = -j 17. Legyen A1 a síkon az

  11. LONG TERM FILE MIGRATION - PART II: FILE REPLACEMENT ALGORITHMS

    E-Print Network [OSTI]

    Jay Smith, Alan

    2011-01-01T23:59:59.000Z

    MIGRATION PART II: FILE REPLACEMENT ALGORITHMS Alan Jaymay vary even though replacement fi~~d the pa~ameter value PIe N - P ;, RT I r:. fILE REPLACEMENT ALGORITHMS. I.lan ~1ar

  12. Published: August 02, 2011 r 2011 American Chemical Society 12910 dx.doi.org/10.1021/ja202277h |J. Am. Chem. Soc. 2011, 133, 1291012913

    E-Print Network [OSTI]

    Mller, Peter

    in a ratiometric fluorescence response. The thin films show orthogonal responses when exposed to cyclic ketones- (trifluoromethyl)phenyl isocyanate, CH2Cl2, rt, 12 h. (ii) Squaric acid, toluene/n-butanol (3:1), r

  13. Commissioning Process and Operational Improvement in the District Heating and Cooling-APCBC

    E-Print Network [OSTI]

    Takase,T.; Takada,O; Shima,K.; Moriya, M.; Shimoda,Y.

    2014-01-01T23:59:59.000Z

    : 2,900kW TR1,2 Centrifugal Chiller (Constant Speed ) Cooling Capacity : 3,516kW (1,000RT) 2 TR3,4 Inverter Centrifugal Chiller Cooling Capacity : 1,758kW (500RT) 2 BTR1,2 Centrifugal Chiller for Ice Storage Cooling Capacity : 1,571kW (447RT) 2 Ice... Making Capacity : 1297kW (369RT) IST1,2 Ice Storage Tank Capacity of Thermal Storage :11,603kWh (3,300RTh) 2 BO1,2 Hot Water Boiler Heating Capacity : 465kW 2 7 ABOUT THE DHC PLANT ESL-IC-14-09-25 Proceedings of the 14th International Conference...

  14. Mixed finite element methods for incompressible flow: Stationary ...

    E-Print Network [OSTI]

    2010-04-14T23:59:59.000Z

    May 14, 2009 ... Received 2 October 2008; accepted 27 January 2009 ... Thomas (RT) element of index k ? 0 and the velocity by piecewise .... We use the standard notations and definitions for the Sobolev spaces Hs( )d and Hs(? )d for.

  15. Kim & Shahidi

    E-Print Network [OSTI]

    1r; = Ad(1r) be the Gelha-rtJacquet lift {(33} of 7L This is a cuspidal repre-. Sentation of .... corresponds t0 {9011)} C ['62, if m, corresponds to {tv} C LGL...

  16. accurate vibrational levels: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hilico; Senem K?l? 2002-07-01 37 Cycle-Accurate Macro-Models for RT-Level Power Analysis* Qinru Qiu, Qing Wu, Massoud Pedram Engineering Websites Summary: not only the...

  17. The Role of O-mannosyl Glycans in Drosophila Development

    E-Print Network [OSTI]

    Lyalin, Dmitry

    2012-10-19T23:59:59.000Z

    . The co-expression of RT and TW is required to generate high-molecular-mass bands of DG. The lectin staining revealed differences in glycan compositions of DG purified from different genetic backgrounds. Overall, this research work established...

  18. PowerCyber: A Cyber-Physical Security Testbed for Smart Grid PI: Manimaran Govindarasu (gmani@iastate.edu)

    E-Print Network [OSTI]

    Manimaran, Govindarasu

    /Opal-RT, provide ability to simulate large power systems with monitoring, protecIon, control modeling bulk power system for cyber security experimentaIons. powercyber power system wherein, vulnerability analysis, system impact studies, risk assessment

  19. Estimating the spatial and temporal distribution of snow in mountainous terrain

    E-Print Network [OSTI]

    Musselman, Keith Newton

    2012-01-01T23:59:59.000Z

    and McMillen, R.T. , 1984. Solar radiation within an oak--J.P. et al. , 2004. Solar radiation transmission through1992. Analysis of solar radiation data for Port Harcourt,

  20. ITP Industrial Distributed Energy: Review of Thermally Activated...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    towards CHP. Technologies Capacity Prime Contractor Partners DOE Award ( million) Gas turbine and LiBr Absorption chillers 5.2MW; 20,000 RT Burns & McDonnell, Kansas City,...

  1. Microbiological, Geochemical and Hydrologic Processes Controlling Uranium Mobility: An Integrated Field Scale Subsurface Research Challenge Site at Rifle, Colorado, February 2011 to January 2012

    E-Print Network [OSTI]

    Long, P.E.

    2013-01-01T23:59:59.000Z

    D.R. , 2008. Sustained removal of uranium from contaminatedAnderson, R.T. , 2007. Uranium Removal from Groundwater viaand highly effective removal of uranium from groundwater at

  2. Decomposition algorithm for large-scale two-stage unit-commitment

    E-Print Network [OSTI]

    2015-04-22T23:59:59.000Z

    D ? RT is the customer load, and A the T n matrix summing up the decision vector x .... able to build a primal feasible solution out of primal iterates and dual...

  3. COO-3095-11

    Office of Scientific and Technical Information (OSTI)

    best available original document. -1- ANNU AL PROG RESS REPO RT, 1973 - '. U. S. ATOMIC ENERGY COMMISS ION CONIR ACT AT (11-1) 3095 Project Abstract This invest igatio n deals...

  4. INTERVIEWER:

    U.S. Energy Information Administration (EIA) Indexed Site

    MMourrtain, PPacific, AAlaskan, HHawaiian Group Code Household ID E RT3 MR, JOHN SMITH 123 MAIN STREET SMALLTOWN, NJ 08600 609-921-0000 1000 Mailing Address: May be...

  5. A genetic bistable switch utilizing nonlinear protein degradation

    E-Print Network [OSTI]

    Huang, Daniel; Holtz, William J; Maharbiz, Michel M

    2012-01-01T23:59:59.000Z

    T: Nonlinear protein degradation and the function of geneticRT: Evolution of the ssrA degradation tag in Mycoplasma:AD: Inducible protein degradation in Bacillus subtilis using

  6. Changes in the Economic Value of Variable Generation at High Penetration Levels: A Pilot Case Study of California

    E-Print Network [OSTI]

    Mills, Andrew

    2013-01-01T23:59:59.000Z

    PV REC RPS RT SAM T&D TES WECC WREZ WWSIS VG VOLL AncillaryCoordinating Council (WECC). http://www.wecc.biz/committees/Coordinating Council (WECC). TEPPC TAS 2020 Dataset

  7. AME 101, Fall 2013 Midterm exam #2 review

    E-Print Network [OSTI]

    really means when the Mach number (M) is not sound speed = (RT)1/2 o Isentropic. Problem #1 (scrutiny) (30 points total) I calculated the power required to pump liquid through a new type

  8. First X-ray crystal structure of an insect muscle myosin /

    E-Print Network [OSTI]

    Caldwell, James Tore

    2013-01-01T23:59:59.000Z

    chromatography The Beckman centrifuge tube (Cat. No. 357448)and decanted into the centrifuge tubes. The solution wasin a Sorvall Legend RT centrifuge (3000g for up to 30 min at

  9. Analysis of Drosophila melanogaster snRNA activating protein complex binding to the U1 gene promoter

    E-Print Network [OSTI]

    Lai, Hsien-Tsung

    2007-01-01T23:59:59.000Z

    out in 4C environment. 3. Centrifuge the lysate at 13,000 XMarathon Micro A desktop centrifuge for 15 minutes to pelletrpm) in Sorvall LegendRT centrifuge, and carefully aspirate

  10. Uncertainty Quantification and Calibration in Well Construction Cost Estimates

    E-Print Network [OSTI]

    Valdes Machado, Alejandro

    2013-08-05T23:59:59.000Z

    Contractual cost of drilling company performed on a daily or hourly basis. Bits & BHA All costs for drill bits and BHA components (purchased or rented): -Key seat wiper, RT tools, watermelon mills -Subs for BHA -Reamers, square drill collars, stabilizers...

  11. Communicating Evolution as Science

    E-Print Network [OSTI]

    Thanukos, Anastasia

    2010-01-01T23:59:59.000Z

    thuringiensis toxins. Science. 1992;258(5087):14515. MillerRT, Ruse M. But is it science? Amherst, NY: Prometheusto the philosophy of science: theory and reality. Chicago:

  12. PHOTOVOLTAIC PROPERTIES OF METAL-MEROCYANINE-TiO2 SANDWICH CELLS

    E-Print Network [OSTI]

    Skotheim, Terje Asbjorn

    2011-01-01T23:59:59.000Z

    used in making the photovoltaic cells. Figure 3. Diagram ofused in making the photovoltaic cells. HO HO ,5 di -t rt.organic compounds in photovoltaic cells. It lies more in the

  13. Rayleigh-Taylor Instability within Sediment Layers Due to Gas Retention: Preliminary Theory and Experiments

    SciTech Connect (OSTI)

    Gauglitz, Phillip A.; Wells, Beric E.; Buchmiller, William C.; Rassat, Scot D.

    2013-03-21T23:59:59.000Z

    In Hanford underground waste storage tanks, a typical waste configuration is settled beds of waste particles beneath liquid layers. The settled beds are typically composed of layers, and these layers can have different physical and chemical properties. One postulated configuration within the settled bed is a less-dense layer beneath a more-dense layer. The different densities can be a result of different gas retention in the layers or different degrees of settling and compaction in the layers. This configuration can experience a Rayleigh-Taylor (RT) instability where the less dense lower layer rises into the upper layer. Previous studies of gas retention and release have not considered potential buoyant motion within a settle bed of solids. The purpose of this report is to provide a review of RT instabilities, discuss predictions of RT behavior for sediment layers, and summarize preliminary experimental observations of RT instabilities in simulant experiments.

  14. Ris-R-706p*f Hydrogen Problems Relatedto

    E-Print Network [OSTI]

    is dedicated to the presentation of the experimental research completed at AECL-Research, Whiteshell Laboratory til beskrivelsen af eksperimenter udført i AECL-Researcn, White- shell Laboratory, hvor effekterne

  15. U.S. Department of Energy Welcomes the United Kingdom as 21st...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Samuel Bodman met with UK Secretary of State for Business, Enterprise and Regulatory Reform, Rt. Hon. John Hutton prior to the UK signing the GNEP Statement of Principles in...

  16. Molecular cloning of the complementary DNA and expression of the endometrial oxytocin receptor during early pregnancy in ewes

    E-Print Network [OSTI]

    Suzuki, Makiko

    1994-01-01T23:59:59.000Z

    Using RT-PCR (Reverse Transcriptase Polymerase Chain Reaction), the oxytocin receptor CDNA between transmembrane domain IV and V region was cloned from ovine endometrium at Day 16 of the estrous cycle. Obtained sequence showed 98% identity and 97...

  17. The Fertilizing Value of Greensand.

    E-Print Network [OSTI]

    Fraps, G. S. (George Stronach)

    1931-01-01T23:59:59.000Z

    . WALKER, Assistant Chemist VELMA GRAHAM. Assistant Chemist T. L. OGIER, B. S., Assistant Chemist ATIIAN J. STERGES, B. S., Assistant Chemist JEANNE M. FUEGAS, Assistant Chemist RAY TREICHLER M 5 Assistant Chemist RALPH L. SCKW~RT~ -6 S. Assisfanf...

  18. PHOTOVOLTAIC PROPERTIES OF METAL-MEROCYANINE-TiO2 SANDWICH CELLS

    E-Print Network [OSTI]

    Skotheim, Terje Asbjorn

    2011-01-01T23:59:59.000Z

    67 3.6 Photovoltaic Action Spectrum . . . . 3.7dye used in making the photovoltaic cells. Figure 3. Diagramused in making the photovoltaic cells. HO HO ,5 di -t rt.

  19. Functional genomics studies of human brain development and implications for autism spectrum disorder

    E-Print Network [OSTI]

    Ziats, Mark

    2014-07-01T23:59:59.000Z

    PET positron emission tomography piRNA Piwi-interacting RNA PMC primary motor cortex PMI post mortem interval PSTC posterior superior temporal cortex qRT-PCR quantitative, real time, polymerase chain reaction RISC RNA-induced silencing complex...

  20. Proteasome Inhibitors Block DNA Repair and Radiosensitize Non-Small Cell Lung Cancer

    E-Print Network [OSTI]

    Cron, Kyle R.

    Despite optimal radiation therapy (RT), chemotherapy and/or surgery, a majority of patients with locally advanced non-small cell lung cancer (NSCLC) fail treatment. To identify novel gene targets for improved tumor control, ...

  1. Ultrafast Control of Magnetism in Ferromagnetic Semiconductors via Photoexcited Transient Carriers

    E-Print Network [OSTI]

    Cotoros, Ingrid A.

    2009-01-01T23:59:59.000Z

    Magnetization dynamics in IIPLM (Ga,Mn)As . . . . . . . . .loop at 5 K . . . . . . . . . IIPLM sample R(T) pro?loop at 5 K . . . . . . . . IIPLM sample M(T) pro?

  2. The effect of resistance, endurance, and combination exercise on lipid metabolism and non-traditional cardiovascular disease risk markers in previously untrained men

    E-Print Network [OSTI]

    Martin, Steven Edward

    2009-05-15T23:59:59.000Z

    and chronic effects of endurance (ET), resistance (RT), and combination endurance / resistance (CT) exercise on lipid metabolism and non-traditional CHD risk markers in untrained men. Thirty-one subjects were randomly assigned to participate for 12 weeks...

  3. STATEMENT OF CONSIDERATIONS REQUEST BY AIR PRODUCTS AND CHEMICALS...

    Broader source: Energy.gov (indexed) [DOE]

    -- - , 1 .3 t fLU4 ' I 04 - -t - rt . .5 * * STATEMENT OF CONSIDERATIONS REQUEST BY AIR PRODUCTS AND CHEMICALS, INC. FOR AN ADVANCE WAIVER OF PATENT RIGHTS UNDER DOE...

  4. IEOR 3106, Fall 2011, Professor Whitt Introduction to Renewal Theory: Tuesday, November 15

    E-Print Network [OSTI]

    Whitt, Ward

    states that lim t R(t) t = E[R1] E[X1] . 3. Long-haul Truck Driver: Driving Back and Forth A truck driver

  5. MSI | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Blog Home content Social Media MSI MSI RT @FrankKlotzNNSA: Many thanks to our outstanding MSI interns-the future leaders of our nuclear enterprise http:1.usa.govXNfDhk...

  6. A Semi-Empirical Growth Estimation Method for Matrix Models of Endangered Species

    E-Print Network [OSTI]

    Rogers-Bennett, Laura Dr.

    2006-01-01T23:59:59.000Z

    P.L. , Taniguchi, I.K. , Rogers-Bennett, L. , 2000. Serial71, 12671274. Rogers-Bennett, L. , Leaf, R.T. Elasticity16, in press. Rogers-Bennett, L. , Haaker, P.A. , Huff,

  7. Using Matrix Models to Evaluate Abalone Conservation and Fishery

    E-Print Network [OSTI]

    Rogers-Bennett, Laura Dr.

    2008-01-01T23:59:59.000Z

    and conservation. Authors: Rogers-Bennett, L. and R.T. Leaf.data. Authors: Rogers-Bennett, L. and D.W. Rogers Date: 2006Analysis Laura Rogers-Bennett University of California,

  8. Turbulence-Flame Interactions in Type Ia Supernovae

    E-Print Network [OSTI]

    Aspden, Andrew J; Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 50A-1148, Berkeley, CA 94720 (Authors 1, 2 & 3); Department of Astronomy and Astrophysics, University of California at Santa Cruz, Santa Cruz, CA 95064 (Author 4); Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY 11794 (Author 5)

    2008-01-01T23:59:59.000Z

    Interactions in Type Ia Supernovae A. J. Aspden 1 , J. B.involved in type Ia supernovae (SN Ia) requires the use of ?generated by RT in type Ia supernovae should obey Bolgiano-

  9. Test Characteristics of Urine Dipstick for Identifying Renal Insufficiency in Patients with Diabetes

    E-Print Network [OSTI]

    Arora, Sanjay; Long, Theodore; Menchine, Michael

    2011-01-01T23:59:59.000Z

    in Patients with Diabetes de Jong PE, Gansevoort RT, BakkerDis. 2002 Jun; 39(6):1190- American Diabetes AssociationFrom Diabetes Care Vol 29, Issue 12, Glauser J, Montgomery

  10. Delicatessen fish products by Norman D. Jarvis

    E-Print Network [OSTI]

    TERI R, tewa rt L. dalJ , ecretary FISII A:-iD WILDlIFE SE R\\,I ut~ke. Camm/ufo"er Bl RHl ' OF C0'1'1f

  11. NETL F 451.1-1/1 Categorical Exclusion (CX) Designation Form

    Broader source: Energy.gov (indexed) [DOE]

    CO2 Storage from Coal-fired Power Facilities in the Black Warrior Basin ofAL Conduct seismic survey along Rt.269 corridor, Walker County, Alabama. 11 9 2009 Karen Cohen Digitally...

  12. NETL F 451.1-1/1 Categorical Exclusion (CX) Designation Form

    Broader source: Energy.gov (indexed) [DOE]

    CO2 Storage from Coal-fired Power Facilities in the Black Warrior Basinof AL Conduct seismic surveys along Rt. 269 corridor or Goodsprings Rd, and along County Road 53 or 61,...

  13. NETL F 451.1-1/1 Categorical Exclusion (CX) Designation Form

    Broader source: Energy.gov (indexed) [DOE]

    CO2 Storage from Coal-fired Power Facilities in the Black Warrior Basinof AL Conduct seismic surveys along Rt. 269 corridor, and along County Road 53 or 61, Walker County,...

  14. Slide 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    m D D - - 6 2 10 ( ) s as as w s T M - + Khler Equation Surface Tension Slide 35 of 46 * 4 0.85 exp ( (85) * ) w as w w p M RT G D ...

  15. atoms technical progress: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    RTF Chair We are just beyond the 12-year consumers money while also protecting the environment. Bruce A. Measure Council Chair Letter FromPoRT The Regional Technical Forum (RTF)...

  16. Reduced MHC and neutral variation in the Galapagos hawk, an island endemic

    E-Print Network [OSTI]

    Bollmer, Jennifer L; Hull, Joshua M; Ernest, Holly B; Sarasola, Jos H; Parker, Patricia G

    2011-01-01T23:59:59.000Z

    RT, Whiteman NK, Sarasola JH, Parker PG: Phylogeography ofBechard MJ, Houston CS, Sarasola JH, England AS: SwainsonsSem Immunol 1994, 61. Sarasola JH, Negro JJ, Hobson KA,

  17. Effect of GTL Diesel Fuels on Emissions and Engine Performance

    Broader source: Energy.gov (indexed) [DOE]

    50 % GTL in EU-Diesel shows almost the same properties as neat GTL: a large reduction in soot emission and a higher EGR tolerance 19 DaimlerChrysler, RT, R. R. Maly,...

  18. Plasma kinetics, tissue distribution, and cerebrocortical sources of reverse triiodothyronine in the rat

    SciTech Connect (OSTI)

    Obregon, M.J.; Larsen, P.R.; Silva, J.E.

    1985-06-01T23:59:59.000Z

    Studies in vitro have shown that rT3 is a potent and competitive inhibitor of T4 5'-deiodination (5'D). Recent studies in vivo have shown that cerebrocortical (Cx) T4 5'D-type II (5'D-II) activity (propylthiouracil (PTU) insensitive pathway), is reduced by T4 and rT3, the latter being more potent than T3 in Cx 5'D-II suppression. Some other reports had described rT3 production in rat brain as a very active pathway of thyroid hormone metabolism. To examine the possibility that rT3 plays a physiological role in regulating Cx 5'D-II, we have explored rT3 plasma kinetics, plasma to tissue exchange, and uptake by tissues in the rat, as well as the metabolic routes of degradation and the sources of rT3 in cerebral cortex (Cx). Plasma and tissue levels were assessed with tracer (/sup 125/I)rT3. Two main compartments were defined by plasma disappearance curves in euthyroid rats (K/sub 1/ = -6.2 h-1 and K/sub 2/ = -0.75 h-1). In Cx of euthyroid rats, (/sup 125/I)rT3 peaked 10 min after iv injection, tissue to plasma ratio being 0.016 +/- 0.004 (SE). In thyroidectomized rats, plasma and tissue (/sup 125/I)rT3 concentrations were higher than in euthyroid rats, except for the Cx that did not change. PTU caused further increases in all the tissues studied, except for the Cx and the pituitaries of thyroidectomized rats. From the effect of blocking 5'D-I with PTU or reducing its activity by making the animals hypothyroid, we concluded that 5'D-I accounts for most of the rT3 clearance from plasma. In contrast, in Cx and pituitary the levels of rT3 seem largely affected by 5'D-II activity. Since the latter results suggest that plasma rT3 does not play a major role in determining rT3 levels in these tissues, we explored the sources of rT3 in Cx using (/sup 125/I)T4. The (/sup 125/I)rT3 (T4) to (/sup 125/I)T4 ratio remained constant at 0.03 from 1 up to 5 h after injection of (/sup 125/I)T4.

  19. Association Between White Blood Cell Count Following Radiation Therapy With Radiation Pneumonitis in Non-Small Cell Lung Cancer

    SciTech Connect (OSTI)

    Tang, Chad; Gomez, Daniel R. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Wang, Hongmei [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou (China); Levy, Lawrence B. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhuang, Yan [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Xu, Ting; Nguyen, Quynh; Komaki, Ritsuko [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Liao, Zhongxing, E-mail: zliao@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2014-02-01T23:59:59.000Z

    Purpose: Radiation pneumonitis (RP) is an inflammatory response to radiation therapy (RT). We assessed the association between RP and white blood cell (WBC) count, an established metric of systemic inflammation, after RT for non-small cell lung cancer. Methods and Materials: We retrospectively analyzed 366 patients with non-small cell lung cancer who received ?60 Gy as definitive therapy. The primary endpoint was whether WBC count after RT (defined as 2 weeks through 3 months after RT completion) was associated with grade ?3 or grade ?2 RP. Median lung volume receiving ?20 Gy (V{sub 20}) was 31%, and post-RT WBC counts ranged from 1.7 to 21.2 10{sup 3} WBCs/?L. Odds ratios (ORs) associating clinical variables and post-RT WBC counts with RP were calculated via logistic regression. A recursive-partitioning algorithm was used to define optimal post-RT WBC count cut points. Results: Post-RT WBC counts were significantly higher in patients with grade ?3 RP than without (P<.05). Optimal cut points for post-RT WBC count were found to be 7.4 and 8.0 10{sup 3}/?L for grade ?3 and ?2 RP, respectively. Univariate analysis revealed significant associations between post-RT WBC count and grade ?3 (n=46, OR=2.6, 95% confidence interval [CI] 1.4?4.9, P=.003) and grade ?2 RP (n=164, OR=2.0, 95% CI 1.2?3.4, P=.01). This association held in a stepwise multivariate regression. Of note, V{sub 20} was found to be significantly associated with grade ?2 RP (OR=2.2, 95% CI 1.2?3.4, P=.01) and trended toward significance for grade ?3 RP (OR=1.9, 95% CI 1.0-3.5, P=.06). Conclusions: Post-RT WBC counts were significantly and independently associated with RP and have potential utility as a diagnostic or predictive marker for this toxicity.

  20. Survival Effect of Neoadjuvant Radiotherapy Before Esophagectomy for Patients With Esophageal Cancer: A Surveillance, Epidemiology, and End-Results Study

    SciTech Connect (OSTI)

    Schwer, Amanda L. [Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, Colorado (United States)], E-mail: amanda.schwer@uchsc.edu; Ballonoff, Ari; McCammon, Robert; Rusthoven, Kyle [Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, Colorado (United States); D'Agostino, Ralph B. [Department of Biostatistical Science, Wake Forest University School of Medicine, Winston-Salem, NC (United States); Schefter, Tracey E. [Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, Colorado (United States)

    2009-02-01T23:59:59.000Z

    Purpose: The role of neoadjuvant radiotherapy (NeoRT) before definitive surgery for esophageal cancer remains controversial. This study used a large population-based database to assess the effect of NeoRT on survival for patients treated with definitive surgery. Methods and Materials: The overall survival (OS) and cause-specific survival for patients with Stage T2-T4, any N, M0 (cT2-T4M0) esophageal cancer who had undergone definitive surgery between 1998 and 2004 were analyzed by querying the Surveillance, Epidemiology, and End-Results database. Kaplan-Meier survival curves were generated and univariate comparisons were made using the log-rank test. Cox proportional hazards survival regression multivariate analysis was performed with NeoRT, T stage (T2 vs. T3-T4), pathologic nodal status (pN0 vs. pN1), number of nodes dissected (>10 vs. {<=}10), histologic type (adenocarcinoma vs. squamous cell carcinoma), age (<65 vs. {>=}65 years), and gender as covariates. Results: A total of 1,033 patients were identified. Of these, 441 patients received NeoRT and 592 underwent esophagectomy alone; 77% were men, 67% had adenocarcinoma, and 72% had Stage T3-T4 disease. The median OS and cause-specific survival were both significantly greater for patients who received NeoRT compared with esophagectomy alone (27 vs. 18 months and 35 vs. 21 months, respectively, p <0.0001). The 3-year OS rate was also significantly greater in the NeoRT group (43% vs. 30%). On multivariate analysis, NeoRT, age <65 years, adenocarcinoma histologic type, female gender, pN0 status, >10 nodes dissected, and Stage T2 disease were all independently correlated with increased OS. Conclusion: These results support the use of NeoRT for patients with esophageal cancer. Prospective studies are needed to confirm these results.

  1. Outcomes and Effect of Radiotherapy in Patients With Stage I or II Diffuse Large B-Cell Lymphoma: A Surveillance, Epidemiology, and End Results Analysis

    SciTech Connect (OSTI)

    Ballonoff, Ari [Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO (United States)], E-mail: ari.ballonoff@uchsc.edu; Rusthoven, Kyle E.; Schwer, Amanda; McCammon, Robert; Kavanagh, Brian; Bassetti, Michael; Newman, Francis; Rabinovitch, Rachel [Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO (United States)

    2008-12-01T23:59:59.000Z

    Purpose: To assess disease-specific survival (DSS), overall survival (OS), and the effect of radiotherapy (RT) in patients with localized diffuse large B-cell lymphoma (DLBCL). Patients and Methods: The Surveillance, Epidemiology, and End Results database was queried for all patients diagnosed with Stage I, IE, II, or IIE DLBCL between 1988 and 2004. The analyzable data included gender, age, race, stage, presence of extranodal disease, and RT administration. Patients who had died or were lost to follow-up within 6 months of diagnosis were excluded. Results: A total of 13,420 patients met the search criteria. Of these, 5,547 (41%) had received RT and 7,873 (59%) had not. RT was associated with a significant DSS (hazard ratio, 0.82, p <0.0001) and OS benefit that persisted during the 15 years of follow-up. Elderly patients, defined either as those >60 or >70 years old, had significantly improved DSS and OS associated with RT. On multivariate analysis, RT was significantly associated with increased DSS and OS. The 5-year DSS outcomes were highly variable among patient subsets, defined by age, stage, and extranodal disease (range for RT-treated patients, 70% for Stage II, age >60 years to 87% for Stage I, age {<=}60 years). Conclusion: This analysis presents the largest detailed data set of Stage I-II DLBCL patients. The results of our study have demonstrated that RT is associated with a survival advantage in patients with localized DLBCL, a benefit that extends to elderly patients. Outcomes for discrete patient subsets varied greatly. The development of tailored therapy according to the relapse risk is warranted, rather than uniform treatment of all early-stage DLBCL.

  2. Radiation-Associated Liver Injury

    SciTech Connect (OSTI)

    Pan, Charlie C., E-mail: cpan@umich.ed [Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI (United States); Kavanagh, Brian D. [Department of Radiation Oncology, University of Colorado, Aurora, CO (United States); Dawson, Laura A. [Princess Margaret Hospital, University of Toronto, Toronto, Ontario (Canada); Li, X. Allen [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States); Das, Shiva K. [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States); Miften, Moyed [Department of Radiation Oncology, University of Colorado, Aurora, CO (United States); Ten Haken, Randall K. [Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI (United States)

    2010-03-01T23:59:59.000Z

    The liver is a critically important organ that has numerous functions including the production of bile, metabolism of ingested nutrients, elimination of many waste products, glycogen storage, and plasma protein synthesis. The liver is often incidentally irradiated during radiation therapy (RT) for tumors in the upper- abdomen, right lower lung, distal esophagus, or during whole abdomen or whole body RT. This article describes the endpoints, time-course, and dose-volume effect of radiation on the liver.

  3. Compact, Convex Upper Bound Iteration for Approximate POMDP Planning

    E-Print Network [OSTI]

    Wang, Tao

    uncertainty How to act based on past experience Maximize long term reward Wide range of applications Robotics and autonomous agent design Helicopter control, Robot navigation and mapping Nursing , Elderly assistance Others #12;POMDP model s0 s0 a1 a1 o1 o1 s1 s1 s2 s2 a2 a2 o2 o2 st st at at ot ot r0 r0 r1 r1 r2 r2 rt rt

  4. Impact of Consolidation Radiation Therapy in Stage III-IV Diffuse Large B-cell Lymphoma With Negative Post-Chemotherapy Radiologic Imaging

    SciTech Connect (OSTI)

    Dorth, Jennifer A., E-mail: jennifer.dorth@duke.edu [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Prosnitz, Leonard R. [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States)] [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Broadwater, Gloria [Cancer Statistical Center, Duke University Medical Center, Durham, North Carolina (United States)] [Cancer Statistical Center, Duke University Medical Center, Durham, North Carolina (United States); Diehl, Louis F.; Beaven, Anne W. [Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, North Carolina (United States)] [Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, North Carolina (United States); Coleman, R. Edward [Department of Radiology, Division of Nuclear Medicine, Duke University Medical Center, Durham, North Carolina (United States)] [Department of Radiology, Division of Nuclear Medicine, Duke University Medical Center, Durham, North Carolina (United States); Kelsey, Chris R. [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States)] [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States)

    2012-11-01T23:59:59.000Z

    Purpose: While consolidation radiation therapy (i.e., RT administered after chemotherapy) is routine treatment for patients with early-stage diffuse large B-cell lymphoma (DLBCL), the role of consolidation RT in stage III-IV DLBCL is controversial. Methods and Materials: Cases of patients with stage III-IV DLBCL treated from 1991 to 2009 at Duke University, who achieved a complete response to chemotherapy were reviewed. Clinical outcomes were calculated using the Kaplan-Meier method and were compared between patients who did and did not receive RT, using the log-rank test. A multivariate analysis was performed using Cox proportional hazards model. Results: Seventy-nine patients were identified. Chemotherapy (median, 6 cycles) consisted of anti-CD20 antibody rituximab combined with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP; 65%); cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP; 22%); or other (13%). Post-chemotherapy imaging consisted of positron emission tomography (PET)/computed tomography (CT) (73%); gallium with CT (14%); or CT only (13%). Consolidation RT (median, 25 Gy) was given to involved sites of disease in 38 (48%) patients. Receipt of consolidation RT was associated with improved in-field control (92% vs. 69%, respectively, p = 0.028) and event-free survival (85% vs. 65%, respectively, p = 0.014) but no difference in overall survival (85% vs. 78%, respectively, p = 0.15) when compared to patients who did not receive consolidation RT. On multivariate analysis, no RT was predictive of increased risk of in-field failure (hazard ratio [HR], 8.01, p = 0.014) and worse event-free survival (HR, 4.3, p = 0.014). Conclusions: Patients with stage III-IV DLBCL who achieve negative post-chemotherapy imaging have improved in-field control and event-free survival with low-dose consolidation RT.

  5. Algebra Lineal (Honores) Tarea 2 Septiembre 5 de 2014

    E-Print Network [OSTI]

    Cardona, Alexander

    Algebra Lineal (Honores) Tarea 2 Septiembre 5 de 2014 I. Responda falso o verdadero(R) Mn(R), definida por T(A) = AT A, es una transformacion lineal. ii. Existe una transformacion lineal transformacion lineal, dim NT = dim (V/RT ). iv. Si T : V V es una transformacion lineal tal que V = NT RT

  6. Patterns of Local Recurrence and Dose Fractionation of Adjuvant Radiation Therapy in 462 Patients With Soft Tissue Sarcoma of Extremity and Trunk Wall

    SciTech Connect (OSTI)

    Jebsen, Nina L., E-mail: nina.louise.jebsen@helse-bergen.no [Department of Clinical Medicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen (Norway); Department of Oncology, Haukeland University Hospital, Bergen (Norway); Engellau, Jacob [Department of Oncology, Skne University Hospital, Lund (Sweden); Engstrm, Katarina [Department of Oncology, Sahlgrenska University Hospital, Gothenburg (Sweden); Bauer, Henrik C. [Department of Molecular Medicine and Surgery, Section for Orthopaedics and Sports Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm (Sweden); Monge, Odd R. [Department of Oncology, Haukeland University Hospital, Bergen (Norway); Muren, Ludvig P. [Department of Physics and Technology, University of Bergen, Bergen (Norway); Department of Medical Physics, Aarhus University and Aarhus University Hospital, Aarhus (Denmark); Eide, Geir E. [Centre for Clinical Research, Haukeland University Hospital, Bergen (Norway); Department of Public Health and Primary Health Care, University of Bergen, Bergen (Norway); Trovik, Clement S. [Department of Clinical Medicine, Faculty of Medicine and Dentistry, University of Bergen, Bergen (Norway); Department of Oncology, Haukeland University Hospital, Bergen (Norway); Bruland, yvind S. [Department of Oncology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo (Norway); Institute of Clinical Medicine, University of Oslo, Oslo (Norway)

    2013-08-01T23:59:59.000Z

    Purpose: To study the impact of dose fractionation of adjuvant radiation therapy (RT) on local recurrence (LR) and the relation of LR to radiation fields. Methods and Materials: LR rates were analyzed in 462 adult patients with soft tissue sarcoma who underwent surgical excision and adjuvant RT at five Scandinavian sarcoma centers from 1998 to 2009. Medical records were reviewed for dose fractionation parameters and to determine the location of the LR relative to the radiation portals. Results: Fifty-five of 462 patients developed a LR (11.9%). Negative prognostic factors included intralesional surgical margin (hazard ratio [HR]: 7.83, 95% confidence interval [CI]: 3.08-20.0), high malignancy grade (HR: 5.82, 95% CI: 1.31-25.8), age at diagnosis (HR per 10 years: 1.27, 95% CI: 1.03-1.56), and malignant peripheral nerve sheath tumor histological subtype (HR: 6.66, 95% CI: 2.56-17.3). RT dose was tailored to margin status. No correlation between RT dose and LR rate was found in multiple Cox regression analysis. The majority (65%) of LRs occurred within the primary RT volume. Conclusions: No significant doseresponse effect of adjuvant RT was demonstrated. Interestingly, patients given 45-Gy accelerated RT (1.8 Gy twice daily/2.5 weeks) had the best local outcome. A total dose of 50 Gy in 25 fractions seemed adequate following wide margin surgery. The risk of LR was associated with histopathologic subtype, which should be included in the treatment algorithm of adjuvant RT in soft tissue sarcoma.

  7. Muddy Water? Variation in Reporting Receipt of Breast Cancer Radiation Therapy by Population-Based Tumor Registries

    SciTech Connect (OSTI)

    Walker, Gary V. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Giordano, Sharon H. [Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Williams, Melanie [Texas Cancer Registry, Department of State Health Services, Austin, Texas (United States)] [Texas Cancer Registry, Department of State Health Services, Austin, Texas (United States); Jiang, Jing [Division of Quantitative Sciences, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Division of Quantitative Sciences, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Niu, Jiangong [Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); MacKinnon, Jill; Anderson, Patricia; Wohler, Brad [Florida Cancer Data System, University of Miami School of Medicine, Miami, Florida (United States)] [Florida Cancer Data System, University of Miami School of Medicine, Miami, Florida (United States); Sinclair, Amber H.; Boscoe, Francis P.; Schymura, Maria J. [New York State Cancer Registry, New York State Department of Health, Albany, New York (United States)] [New York State Cancer Registry, New York State Department of Health, Albany, New York (United States); Buchholz, Thomas A. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Smith, Benjamin D., E-mail: BSmith3@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-07-15T23:59:59.000Z

    Purpose: To evaluate, in the setting of breast cancer, the accuracy of registry radiation therapy (RT) coding compared with the gold standard of Medicare claims. Methods and Materials: Using Surveillance, Epidemiology, and End Results (SEER)Medicare data, we identified 73,077 patients aged ?66 years diagnosed with breast cancer in the period 2001-2007. Underascertainment (1 - sensitivity), sensitivity, specificity, ?, and ?{sup 2} were calculated for RT receipt determined by registry data versus claims. Multivariate logistic regression characterized patient, treatment, and geographic factors associated with underascertainment of RT. Findings in the SEERMedicare registries were compared with three non-SEER registries (Florida, New York, and Texas). Results: In the SEERMedicare registries, 41.6% (n=30,386) of patients received RT according to registry coding, versus 49.3% (n=36,047) according to Medicare claims (P<.001). Underascertainment of RT was more likely if patients resided in a newer SEER registry (odds ratio [OR] 1.70, 95% confidence interval [CI] 1.60-1.80; P<.001), rural county (OR 1.34, 95% CI 1.21-1.48; P<.001), or if RT was delayed (OR 1.006/day, 95% CI 1.006-1.007; P<.001). Underascertainment of RT receipt in SEER registries was 18.7% (95% CI 18.6-18.8%), compared with 44.3% (95% CI 44.0-44.5%) in non-SEER registries. Conclusions: Population-based tumor registries are highly variable in ascertainment of RT receipt and should be augmented with other data sources when evaluating quality of breast cancer care. Future work should identify opportunities for the radiation oncology community to partner with registries to improve accuracy of treatment data.

  8. Characterization of the 3' terminal 42 nucleotide host protein binding element of the mouse hepatitis virus 3' untranslated region

    E-Print Network [OSTI]

    Johnson, Reed Findley

    2004-09-30T23:59:59.000Z

    Overview of the selection process for Alb4 recombinants???????... 77 18 Plaque dilution of ATW5', B36 and A59 controls??????..????? 79 19 RT-PCR of potential mutant recombinants????????..????... 80 20 Panel A is a representative experiment... for mutants MT2A, MT3C, and M24C????????????????????.. 92 21 A representative RT-PCR for negative strand DI RNA??????.???. 94 22 Panel A is a representative experiment for mutants ATW, ATW5', and ATW3'????????????????????. 96 23 Semi...

  9. Physical Constants g = 9.80 m/s2

    E-Print Network [OSTI]

    Wysin, Gary

    , Heat Pumps: W = QH - QL, refrigerators: COP = QL W , heat pumps: COP = QH W , QL QH = TL TH for ideal, V = V0T. Ideal Gas Law: PV = nRT, or PV = NkT, R = 8.314 J/molK, k = R NA = 1.38 10-23 J Internal Energy: U = 3 2 NkT = 3 2 nRT, for ideal monatomic gases. Mechanical Equivalent of Heat, Specific

  10. Dynamic workload characterization for energy efficient computing

    E-Print Network [OSTI]

    Dhiman, Gaurav

    2011-01-01T23:59:59.000Z

    f u ke im art plu mc mc 2ar ppl qua a-2sw 2-2ap ip2-2 c-2 -2e r 2pe m swi rl-2 2pe u ppl -2a esa 2m rt -2a esa 2m f cf2 p 2ap f t u ake wim Avg mc ppl rt-2ar equ im-2s cf-2 2a m

  11. Litt om evolusjonr spillteori. 1. ESS: Evolusjonrt Stabile Strategier

    E-Print Network [OSTI]

    Løw, Erik

    Litt om evolusjonær spillteori. 1. ESS: Evolusjonært Stabile Strategier I klassisk spillteori har konstant i tid. Spørsm°alet er om man kan si noe om denne (stabile) strategifordelingen. 1.1. ESS. La være av befolk- ningen. Vi sier at p er en Evolusjonært Stabil Strategi (ESS) hvis p ikke kan bli invadert

  12. The Efficacy of Radiation Therapy in the Treatment of Graves' Orbitopathy

    SciTech Connect (OSTI)

    Matthiesen, Chance, E-mail: chance-matthiesen@ouhsc.edu [Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States); Thompson, J. Spencer [Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States); Thompson, David [Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States); Farris, Bradley; Wilkes, Byron [Dean A. McGee Eye Institute, Oklahoma City, OK (United States); Ahmad, Salahuddin; Herman, Terence; Bogardus, Carl [Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK (United States)

    2012-01-01T23:59:59.000Z

    Purpose: To review our institutional outcomes of patients treated with radiation therapy (RT) for Graves' orbitopathy (GO), assess the role of orbital reirradiation, and identify prognostic factors of complete response (CR). Methods and Materials: This is a retrospective review of 211 patients who presented with a diagnosis of GO and received RT between January 2000-2010. RT dose was 20 Gy in 10 fractions. Patient median age was 51 years (range, 15-84 years), median follow-up was 11 months (range, 1-88 months). Patient symptoms included any combination of proptosis (90.9%), extraocular muscle dysfunction (78.9%), soft tissue signs (68.4%), and diplopia (58.4%). Corticosteroids were used as first-line therapy in 20.6% of patients. Among those who achieved either CR or partial response (PR), prognostic factors were evaluated. Results: Stabilization of disease without recurrence was clinically achieved overall in 202 patients (96.7%). At the completion of RT, 176 patients (84.2%) reported a symptomatic improvement of pretreatment symptoms. CR of GO symptoms was achieved using multiple treatment modalities, including RT by 93 patients (44.5%), of which 32 patients received RT only. Corticosteroids were discontinued in 97.8% of patients who received them as initial therapy. Surgical intervention following radiotherapy was required for 144 (68.9%) of all patients. Fourteen patients received orbital reirradiation for persistent or recurrent symptoms. Five of these achieved a CR, and the other nine achieved disease stabilization but retained persistent ocular symptoms. Long-term side effects of RT included dry eyes (12%). Of the prognostic factors we investigated, only gender predicted CR, which was less common in men (33.9%) than in women (49.7%) p = 0.0471. Conclusions: Orbital radiation for GO is an established treatment modality for patients. Orbital reirradiation is beneficial for patients who do not respond to initial RT or experience symptom recurrence without an apparent risk of increased morbidity.

  13. Management of Adenoid Cystic Carcinoma of the Breast: A Rare Cancer Network Study

    SciTech Connect (OSTI)

    Khanfir, Kaouthar, E-mail: kaouthar.khanfir@rsv-gnw.ch [Hopital de Sion, CHCVs, Sion (Switzerland); Kallel, Adel [Institut Gustave Roussy, Villejuif (France); Villette, Sylviane [Centre Rene Huguenin, Paris (France); Belkacemi, Yazid [CHU Henri Mondor, Centre Oscar Lambret, Lille (France); Vautravers, Claire [Centre George Francois Leclerc, Dijon (France); Nguyen, TanDat [Institut Jean Gaudinot, Reims (France); Miller, Robert [Mayo Clinic, Rochester, Minnesota (United States); Li Yexiong [Peking Union Medical College, Beijing (China); Taghian, Alphonse G. [Massachusetts General Hospital, Boston, Massachusetts (United States); Boersma, Liesbeth [Maastricht University Medical Center (MAASTRO clinic), Maastricht (Netherlands); Poortmans, Philip [Dr. Bernard Verbeeten Institute, Tilburg (Netherlands); Goldberg, Hadassah [Western Galilee Hospital-Nahariya, Nahariya (Israel); Vees, Hansjorg [Hopitaux Universitaires de Geneve, Geneva (Switzerland); Senkus, Elzbieta [Medical University of Gdansk, Gdansk (Poland); Igdem, Sefik; Ozsahin, Mahmut [Istanbul Bilim University, Istanbul (Turkey); Jeanneret Sozzi, Wendy [Centre Hospitalier Universitaire Vaudois, Lausanne (Switzerland)

    2012-04-01T23:59:59.000Z

    Background: Mammary adenoid cystic carcinoma (ACC) is a rare breast cancer. The aim of this retrospective study was to assess prognostic factors and patterns of failure, as well as the role of radiation therapy (RT), in ACC. Methods: Between January 1980 and December 2007, 61 women with breast ACC were treated at participating centers of the Rare Cancer Network. Surgery consisted of lumpectomy in 41 patients and mastectomy in 20 patients. There were 51(84%) stage pN0 and 10 stage cN0 (16%) patients. Postoperative RT was administered to 40 patients (35 after lumpectomy, 5 after mastectomy). Results: With a median follow-up of 79 months (range, 6-285), 5-year overall and disease-free survival rates were 94% (95% confidence interval [CI], 88%-100%) and 82% (95% CI, 71%-93%), respectively. The 5-year locoregional control (LRC) rate was 95% (95% CI, 89%-100%). Axillary lymph node dissection or sentinel node biopsy was performed in 84% of cases. All patients had stage pN0 disease. In univariate analysis, survival was not influenced by the type of surgery or the use of postoperative RT. The 5-year LRC rate was 100% in the mastectomy group versus 93% (95% CI, 83%-100%) in the breast-conserving surgery group, respectively (p = 0.16). For the breast-conserving surgery group, the use of RT significantly correlated with LRC (p = 0.03); the 5-year LRC rates were 95% (95% CI, 86%-100%) for the RT group versus 83% (95% CI, 54%-100%) for the group receiving no RT. No local failures occurred in patients with positive margins, all of whom received postoperative RT. Conclusion: Breast-conserving surgery is the treatment of choice for patients with ACC breast cancer. Axillary lymph node dissection or sentinel node biopsy might not be recommended. Postoperative RT should be proposed in the case of breast-conserving surgery.

  14. High-Temperature Steam-Treatment of PBI, PEEK, and PEKK Polymers with H2O and D2O: A Solid-State NMR Study

    E-Print Network [OSTI]

    Bluemel, Janet

    1 High-Temperature Steam-Treatment of PBI, PEEK, and PEKK Polymers with H2O and D2O: A Solid Supplementary Information Figure S1. TGA of melt-molded PBI after stirring in H2O at RT and steam-treatment with H2O at 150 °C and 315 °C. Figure S2. TGA of melt-molded PEEK after stirring in D2O at RT and steam

  15. Effects of various oilseed proteins on the sensory and storage stability properties of vacuum packaged frankfurters

    E-Print Network [OSTI]

    Brown, John Axtell

    1979-01-01T23:59:59.000Z

    r-'I V 0 Crr V Cd 0 0 0 D 0 W 8 0 t-I 0 8 C4 8 '0 8 '0 N cn cv cv cn orr O O rrt 4 0 mr 0 O l4 rd N 4 0 8 0 N 0VJ Q W O o nj cu SW QJ W UJ 8 W OCJ 0 W A 800 N 0 0 8 UJ nd 4J 8 0 N 4 UGN C4 8 0 rrn O OO 8 8 0 8 8 M... four-week period, one sample per week. 0 R PI 0 VI 8 '0 I V 0 rt V- 0 0' ~ V H IU nodp V Ul 0 * I-U lrl (D O dP Pl '0 III 0' 0 rt 8 UU rt V. O 8 dP PI mo 0 0 rt IP I 8 V ~ V Ul rt 8 0 n 8 0 Ql V I Ul PP 0 N '0 It 0 rt 0...

  16. Biologically Effective Dose-Response Relationship for Breast Cancer Treated by Conservative Surgery and Postoperative Radiotherapy

    SciTech Connect (OSTI)

    Plataniotis, George A. [Department of Oncology, Aberdeen Royal Infirmary, Aberdeen (United Kingdom)], E-mail: george.plataniotis@nhs.net; Dale, Roger G. [Imperial College Healthcare NHS Trust, London (United Kingdom)

    2009-10-01T23:59:59.000Z

    Purpose: To find a biologically effective dose (BED) response for adjuvant breast radiotherapy (RT) for initial-stage breast cancer. Methods and Materials: Results of randomized trials of RT vs. non-RT were reviewed and the tumor control probability (TCP) after RT was calculated for each of them. Using the linear-quadratic formula and Poisson statistics of cell-kill, the average initial number of clonogens per tumor before RT and the average tumor cell radiosensitivity (alpha-value) were calculated. An {alpha}/{beta} ratio of 4 Gy was assumed for these calculations. Results: A linear regression equation linking BED to TCP was derived: -ln[-ln(TCP)] = -ln(No) + {alpha}{sup *} BED = -4.08 + 0.07 * BED, suggesting a rather low radiosensitivity of breast cancer cells (alpha = 0.07 Gy{sup -1}), which probably reflects population heterogeneity. From the linear relationship a sigmoid BED-response curve was constructed. Conclusion: For BED values higher than about 90 Gy{sub 4} the radiation-induced TCP is essentially maximizing at 90-100%. The relationship presented here could be an approximate guide in the design and reporting of clinical trials of adjuvant breast RT.

  17. Long-Term Experience With World Health Organization Grade III (Malignant) Meningiomas at a Single Institution

    SciTech Connect (OSTI)

    Rosenberg, Lewis A. [Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH (United States); Case Western Reserve University School of Medicine, Cleveland, OH (United States); Prayson, Richard A. [Department of Pathology, Cleveland Clinic Foundation, Cleveland, OH (United States); Lee, Joung [Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, OH (United States); Reddy, Chandana; Chao, Samuel T. [Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH (United States); Barnett, Gene H.; Vogelbaum, Michael A. [Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, OH (United States); Suh, John H. [Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH (United States)], E-mail: suhj@ccf.org

    2009-06-01T23:59:59.000Z

    Purpose: To evaluate the outcomes for patients with Grade III meningiomas as defined by the 2007 World Health Organization standards. Methods and Materials: The slides from patients who had been treated at the Cleveland Clinic for malignant meningiomas were reviewed by a single neuropathologist. The data from 13 patients treated between 1984 and 2006 satisfied the World Health Organization 2007 definition of Grade III meningioma. A total of 24 surgeries were performed, including 13 primary, 7 salvage, and 4 second salvage. Also, 14 courses of radiotherapy (RT) were administered, including fractionated RT in 3 patients after primary surgery, fractionated RT in 4 patients after salvage surgery, salvage stereotactic radiosurgery to six separate areas in 3 patients, and salvage intensity-modulated RT in 1 patient. Results: From the primary surgery, the median survival was 3.4 years, the 5-year survival rate was 47.2%, and the 8-year survival rate was 12.2%. The median time to recurrence was 9.6 months. A trend was seen toward longer survival for patients who had received adjuvant RT after initial surgery compared with those treated with surgery alone. Two patients developed radiation necrosis, and three had surgical complications. Conclusion: This is one of the few studies reporting the outcomes for malignant meningioma patients according to recent definitions. Our results are consistent with existing reports of the overall poor outcomes for atypical and malignant meningioma patients. From the available data, surgical resection followed by RT and salvage therapy can lead to extended survival.

  18. The effects of high temperature processing on the structural and optical properties of oxygenated CdS window layers in CdTe solar cells

    SciTech Connect (OSTI)

    Paudel, Naba R.; Grice, Corey R.; Xiao, Chuanxiao; Yan, Yanfa [Department of Physics and Astronomy, and Wright Center for Photovoltaics Innovation and Commercialization, The University of Toledo, Toledo, Ohio 43606 (United States)

    2014-07-28T23:59:59.000Z

    High efficiency CdTe solar cells typically use oxygenated CdS (CdS:O) window layers. We synthesize CdS:O window layers at room temperature (RT) and 270?C using reactive sputtering. The band gaps of CdS:O layers deposited at RT increase when O{sub 2}/(O{sub 2}?+?Ar) ratios in the deposition chamber increase. On the other hand, the band gaps of CdS:O layers deposited at 270?C decrease as the O{sub 2}/(O{sub 2}?+?Ar) ratios increase. Interestingly, however, our high temperature closed-space sublimation (CSS) processed CdTe solar cells using CdS:O window layers deposited at RT and 270?C exhibit very similar cell performance, including similar short-circuit current densities. To understand the underlying reasons, CdS:O thin films deposited at RT and 270?C are annealed at temperatures that simulate the CSS process of CdTe deposition. X-ray diffraction, atomic force microscopy, and UV-visible light absorption spectroscopy characterization of the annealed films reveals that the CdS:O films deposited at RT undergo grain regrowth and/or crystallization and exhibit reduced band gaps after the annealing. Our results suggest that CdS:O thin films deposited at RT and 270?C should exhibit similar optical properties after the deposition of CdTe layers, explaining the similar cell performance.

  19. Patterns and Predictors of Early Biochemical Recurrence After Radical Prostatectomy and Adjuvant Radiation Therapy in Men With pT{sub 3}N{sub 0} Prostate Cancer: Implications for Multimodal Therapies

    SciTech Connect (OSTI)

    Briganti, Alberto, E-mail: briganti.alberto@hsr.it [Department of Urology, San Raffaele Scientific Institute, Vita-Salute University, Milan (Italy); Joniau, Steven [Department of Urology, University Hospitals Leuven, Leuven (Belgium); Gandaglia, Giorgio [Department of Urology, San Raffaele Scientific Institute, Vita-Salute University, Milan (Italy); Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal (Canada); Cozzarini, Cesare [Department of Radiotherapy, San Raffaele Scientific Institute, Milan (Italy); Sun, Maxine [Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal (Canada); Tombal, Bertrand [Department of Urology, Universit Catholique de Louvain, Brussels (Belgium); Haustermans, Karin [Department of Radiology, University Hospitals Leuven, Leuven (Belgium); Hinkelbein, Wolfgang [Department of Radiation Oncology, Charit Universittsmedizin, Campus Benjamin Franklin, Berlin (Germany); Shariat, Shahrokh F. [Department of Urology, University of Vienna, Vienna (Austria); Karakiewicz, Pierre I. [Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal (Canada); Montorsi, Francesco [Department of Urology, San Raffaele Scientific Institute, Vita-Salute University, Milan (Italy); Van Poppel, Hein [Department of Urology, University Hospitals Leuven, Leuven (Belgium); Wiegel, Thomas [Department of Radiation Oncology, University Hospital Ulm, Ulm (Germany)

    2013-12-01T23:59:59.000Z

    Purpose: The aim of our study was to evaluate patterns and predictors of early biochemical recurrence (eBCR) after radical prostatectomy (RP) and adjuvant radiation therapy (aRT) in order to identify which individuals might benefit from additional treatments. Methods and Materials: We evaluated 390 patients with pT{sub 3}N{sub 0} prostate cancer (PCa) receiving RP and aRT at 6 European centers between 1993 and 2006. Patients who were free from BCR at <2 years' follow-up were excluded. This resulted in 374 assessable patients. Early BCR was defined as 2 consecutive prostate-specific antigen (PSA) test values >0.2 ng/mL within 2 or 3 years after aRT. Uni- and multivariable Cox regression analyses predicting overall and eBCR after aRT were fitted. Covariates consisted of preoperative PSA results, surgical margins, pathological stage, Gleason score, and aRT dose. Results: Overall, 5- and 8-year BCR-free survival rates were 77.1% and 70.8%, respectively. At a median follow-up of 86 months after aRT, 33 (8.8%) and 55 (14.6%) men experienced BCR within 2 or 3 years after aRT, respectively. In multivariable analyses, Gleason scores of 8 to 10 represented the only independent predictor of eBCR after aRT (all, P?.01). The risk of BCR was significantly higher in patients with a Gleason score of 8 to 10 disease than in those with Gleason 2 to 6 within 24 months after treatment, after adjusting for all covariates (all, P?.04). However, given a 24-month BCR free period, the risk of subsequent BCR for men with poorly differentiated disease was equal to that of men with less aggressive disease (all, P?.3). Conclusions: High Gleason score represents the only predictor of eBCR after RP and aRT in patients affected by pT{sub 3}N{sub 0} PCa. Given the association between early PSA recurrence, clinical progression, and mortality, these patients might be considered candidates for adjuvant medical therapy and/or prophylactic whole-pelvis radiation therapy in addition to aRT, delivered to the prostatic bed.

  20. Self-Reported Cognitive Outcomes in Patients With Brain Metastases Before and After Radiation Therapy

    SciTech Connect (OSTI)

    Cole, Ansa Maer [Department of Radiation Oncology, Medical School Hannover, Hannover (Germany); Scherwath, Angela [Department of Medical Psychology, University Medical Centre Hamburg-Eppendorf, Hamburg (Germany); Ernst, Gundula [Department of Medical Psychology, Medical School Hannover, Hannover (Germany); Lanfermann, Heinrich [Institute for Neuroradiology, Medical School Hannover, Hannover (Germany); Bremer, Michael [Department of Radiation Oncology, Medical School Hannover, Hannover (Germany); Steinmann, Diana, E-mail: steinmann.diana@mh-hannover.de [Department of Radiation Oncology, Medical School Hannover, Hannover (Germany)

    2013-11-15T23:59:59.000Z

    Purpose: Patients with brain metastases may experience treatment-related cognitive deficits. In this study, we prospectively assessed the self-reported cognitive abilities of patients with brain metastases from any solid primary cancer before and after irradiation of the brain. Methods and Materials: The treatment group (TG) consisted of adult patients (n=50) with brain metastases who received whole or partial irradiation of the brain without having received prior radiation therapy (RT). The control group (CG) consisted of breast cancer patients (n=27) without cranial involvement who were treated with adjuvant RT. Patients were recruited between May 2008 and December 2010. Self-reported cognitive abilities were acquired before RT and 6 weeks, 3 months, and 6 months after irradiation. The information regarding the neurocognitive status was collected by use of the German questionnaires for self-perceived deficits in attention (FEDA) and subjectively experienced everyday memory performance (FEAG). Results: The baseline data showed a high proportion of self-perceived neurocognitive deficits in both groups. A comparison between the TG and the CG regarding the course of self-reported outcomes after RT showed significant between-group differences for the FEDA scales 2 and 3: fatigue and retardation of daily living activities (P=.002) and decrease in motivation (P=.032) with an increase of attention deficits in the TG, but not in the CG. There was a trend towards significance in FEDA scale 1: distractibility and retardation of mental processes (P=.059) between the TG and the CG. The FEAG assessment presented no significant differences. An additional subgroup analysis within the TG was carried out. FEDA scale 3 showed significant differences in the time-related progress between patients with whole-brain RT and those receiving hypofractionated stereotactic RT (P=.025), with less decrease in motivation in the latter group. Conclusion: Self-reported attention declined in patients with brain metastases after RT to the brain, whereas it remained relatively stable in breast cancer patients.

  1. The mitigating effect of magnetic fields on Rayleigh-Taylor unstable inertial confinement fusion plasmas

    SciTech Connect (OSTI)

    Srinivasan, Bhuvana; Tang, Xian-Zhu [Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States)] [Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States)

    2013-05-15T23:59:59.000Z

    Rayleigh-Taylor (RT) instabilities at interfaces of disparate mass densities have long been known to generate magnetic fields during inertial confinement fusion implosions. An externally applied magnetic field can also be efficiently amplified by RT instabilities. The focus here is on magnetic field generation and amplification at the gas-ice interface which is RT unstable during the deceleration phase of the implosion. RT instabilities lead to undesirable mix of hot and cold plasmas which enhances thermal energy loss and tends to produce a more massive warm-spot instead of a hot-spot. Two mechanisms are shown here to mitigate the thermal energy loss from the hot-spot. The first mechanism is the reduction of electron thermal conductivity with interface-aligned magnetic fields. This can occur through self-generated magnetic fields via the Biermann battery effect as well as through externally applied magnetic fields that undergo an exponential growth via the stretch-and-fold magnetohydrodynamic dynamo. Self-generated magnetic fields during RT evolution can result in a factor of 2?10 decrease in the electron thermal conductivity at the gas-ice interface, while externally applied magnetic fields that are compressed to 61000 T at the onset of deceleration (corresponding to pre-implosion external fields of 0.0610 T) could result in a factor of 2500 reduction in electron thermal conductivity at the gas-ice interface. The second mechanism to mitigate thermal energy loss from the hot-spot is to decrease the interface mixing area between the hot and cold plasmas. This is achieved through large external magnetic fields of 1000 T at the onset of deceleration which damp short-wavelength RT modes and long-wavelength Kelvin-Helmholtz modes thus significantly slowing the RT growth and reducing mix.

  2. Five-Year Results From a Scandinavian Sarcoma Group Study (SSG XIII) of Adjuvant Chemotherapy Combined With Accelerated Radiotherapy in High-Risk Soft Tissue Sarcoma of Extremities and Trunk Wall

    SciTech Connect (OSTI)

    Jebsen, Nina L. [Department of Surgical Sciences, University of Bergen Faculty of Medicine, Bergen, Norway and Department of Oncology, Haukeland University Hospital, Bergen (Norway); Bruland, Oyvind S. [Cancer Clinic, Norwegian Radium Hospital, Oslo University Hospital and University of Oslo Faculty Division, Clinical Medicine, Oslo (Norway); Eriksson, Mikael; Engellau, Jacob [Department of Oncology, Skane University Hospital, Lund (Sweden); Turesson, Ingela [Department of Oncology, Uppsala University Hospital, Uppsala (Sweden); Folin, Annika [Department of Oncology, Karolinska Hospital, Stockholm (Sweden); Trovik, Clement S. [Departments of Oncology and of Orthopedics, Haukeland University Hospital, Bergen (Norway); Hall, Kirsten Sundby [Cancer Clinic, Norwegian Radium Hospital, Oslo University Hospital, Oslo (Norway)

    2011-12-01T23:59:59.000Z

    Purpose: To evaluate adjuvant chemotherapy and interpolated accelerated radiotherapy (RT) for adult patients with high-risk soft tissue sarcoma in the extremities or trunk wall. Methods and Materials: High-risk soft tissue sarcoma was defined as high-grade malignancy and at least two of the following criteria: size {>=}8 cm, vascular invasion, or necrosis. Six cycles of doxorubicin and ifosfamide were prescribed for all patients. RT to a total dose of 36 Gy (1.8 Gy twice daily) was inserted between two chemotherapy cycles after marginal margin resection regardless of tumor depth or after wide-margin resection for deep-seated tumors. RT was boosted to 45 Gy in a split-course design in the case of intralesional margin resection. Results: A total of 119 patients were eligible, with a median follow-up of 5 years. The 5-year estimate of the local recurrence, metastasis-free survival, and overall survival rate was 12%, 59%, and 68%, respectively. The group receiving RT to 36 Gy had a local recurrence rate of 10%. In contrast, the local recurrence rate was 29% in the group treated with RT to 45 Gy. The presence of vascular invasion and low chemotherapy dose intensity had a negative effect on metastasis-free and overall survival. Toxicity was moderate after both the chemotherapy and the RT. Conclusions: Accelerated RT interposed between chemotherapy cycles in a selected population of patients with high-risk soft tissue sarcoma resulted in good local and distant disease control, with acceptable treatment-related morbidity. The greater radiation dose administered after intralesional surgery was not sufficient to compensate for the poorer surgical margin. Vascular invasion was the most important prognostic factor for metastasis-free and overall survival.

  3. PSA Response to Neoadjuvant Androgen Deprivation Therapy Is a Strong Independent Predictor of Survival in High-Risk Prostate Cancer in the Dose-Escalated Radiation Therapy Era

    SciTech Connect (OSTI)

    McGuire, Sean E., E-mail: semcguir@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas (United States); Lee, Andrew K. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Cerne, Jasmina Z. [Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas (United States)] [Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas (United States); Munsell, Mark F. [Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Levy, Lawrence B. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Kudchadker, Rajat J. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Choi, Seungtaek L.; Nguyen, Quynh N.; Hoffman, Karen E.; Pugh, Thomas J.; Frank, Steven J. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Corn, Paul G.; Logothetis, Christopher J. [Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Kuban, Deborah A. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-01-01T23:59:59.000Z

    Purpose: The aim of the study was to evaluate the prognostic value of prostate-specific antigen (PSA) response to neoadjuvant androgen deprivation therapy (ADT) prior to dose-escalated radiation therapy (RT) and long-term ADT in high-risk prostate cancer. Methods and Materials: We reviewed the charts of all patients diagnosed with high-risk prostate cancer and treated with a combination of long-term ADT (median, 24 months) and dose-escalated (median, 75.6 Gy) RT between 1990 and 2007. The associations among patient, tumor, and treatment characteristics with biochemical response to neoadjuvant ADT and their effects on failure-free survival (FFS), time to distant metastasis (TDM), prostate cancer-specific mortality (PCSM) and overall survival (OS) were examined. Results: A total of 196 patients met criteria for inclusion. Median follow-up time for patients alive at last contact was 7.0 years (range, 0.5-18.1 years). Multivariate analysis identified the pre-RT PSA concentration (<0.5 vs {>=}0.5 ng/mL) as a significant independent predictor of FFS (P=.021), TDM (P=.009), PCSM (P=.039), and OS (P=.037). On multivariate analysis, pretreatment PSA (iPSA) and African-American race were significantly associated with failure to achieve a pre-RT PSA of <0.5 ng/mL. Conclusions: For high-risk prostate cancer patients treated with long-term ADT and dose-escalated RT, a pre-RT PSA level {>=}0.5 ng/mL after neoadjuvant ADT predicts for worse survival measures. Both elevated iPSA and African-American race are associated with increased risk of having a pre-RT PSA level {>=}0.5 ng/mL. These patients should be considered for clinical trials that test newer, more potent androgen-depleting therapies such as abiraterone and MDV3100 in combination with radiation.

  4. Central neurocytoma: Management recommendations based on a 35-year experience

    SciTech Connect (OSTI)

    Leenstra, James L. [Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, MN (United States); Rodriguez, Fausto J. [Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (United States); Frechette, Christina M. [Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, MN (United States); Giannini, Caterina [Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (United States); Stafford, Scott L. [Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, MN (United States); Pollock, Bruce E. [Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, MN (United States); Department of Neurologic Surgery, Mayo Clinic College of Medicine, Rochester, MN (United States); Schild, Steven E. [Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ (United States); Scheithauer, Bernd W. [Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (United States); Jenkins, Robert B. [Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (United States); Buckner, Jan C. [Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, MN (United States); Brown, Paul D. [Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, MN (United States)

    2007-03-15T23:59:59.000Z

    Purpose: To examine the outcomes of patients with histologically confirmed central neurocytomas. Methods and Materials: The data from 45 patients with central neurocytomas diagnosed between 1971 and 2003 were retrospectively evaluated. Various combinations of surgery, radiotherapy (RT), and chemotherapy had been used for treatment. Results: The median follow-up was 10.0 years. The 10-year overall survival and local control rate was 83% and 60%, respectively. Patients whose tumor had a mitotic index of <3 (per 10 high-power fields) experienced a 10-year survival and local control rate of 89% and 74%, respectively, compared with 57% (p = 0.040) and 46% (p = 0.14) for patients with a tumor mitotic index of {>=}3. The 10-year survival and local control rate was 90% and 74% for patients with typical tumors compared with 63% (p = 0.055) and 46% (p = 0.41) for those with atypical tumors. A comparison of gross total resection with subtotal resection showed no significant difference in survival or local control. Postoperative RT improved local control at 10 years (75% with RT vs. 51% without RT, p = 0.045); however, this did not translate into a survival benefit. No 1p19q deletions were found in the 19 tumors tested. Conclusion: Although the overall prognosis is quite favorable, one-third of patients experienced tumor recurrence or progression at 10 years, regardless of the extent of the initial resection. Postoperative RT significantly improved local control but not survival, most likely because of the effectiveness of salvage RT. For incompletely resected atypical tumors and/or those with a high mitotic index, consideration should be given to adjuvant RT because of the more aggressive nature.

  5. Hypofractionated Radiation Therapy for Breast Ductal Carcinoma In Situ

    SciTech Connect (OSTI)

    Hathout, Lara [Department of Radiation Oncology, Hpital Maisonneuve-Rosemont, Centre affili l'Universit de Montral, Montreal, Quebec (Canada); Hijal, Tarek [Department of Radiation Oncology, McGill University Health Centre, Montreal, Quebec (Canada); Thberge, Valrie [Department of Radiation Oncology, Centre hospitalier universitaire de Qubec, L'Htel-Dieu de Qubec, Quebec (Canada); Centre des maladies du sein Deschnes-Fabia, Quebec (Canada); Fortin, Bernard [Department of Radiation Oncology, Hpital Maisonneuve-Rosemont, Centre affili l'Universit de Montral, Montreal, Quebec (Canada); Vulpe, Horia [Department of Radiation Oncology, McGill University Health Centre, Montreal, Quebec (Canada); Hogue, Jean-Charles [Centre des maladies du sein Deschnes-Fabia, Quebec (Canada); Centre hospitalier universitaire de Qubec, Hpital St-Sacrement, Quebec (Canada); Lambert, Christine [Department of Radiation Oncology, McGill University Health Centre, Montreal, Quebec (Canada); Bahig, Houda [Department of Radiation Oncology, Hpital Maisonneuve-Rosemont, Centre affili l'Universit de Montral, Montreal, Quebec (Canada); and others

    2013-12-01T23:59:59.000Z

    Purpose: Conventional radiation therapy (RT) administered in 25 fractions after breast-conserving surgery (BCS) is the standard treatment for ductal carcinoma in situ (DCIS) of the breast. Although accelerated hypofractionated regimens in 16 fractions have been shown to be equivalent to conventional RT for invasive breast cancer, few studies have reported results of using hypofractionated RT in DCIS. Methods and Materials: In this multicenter collaborative effort, we retrospectively reviewed the records of all women with DCIS at 3 institutions treated with BCS followed by hypofractionated whole-breast RT (WBRT) delivered in 16 fractions. Results: Between 2003 and 2010, 440 patients with DCIS underwent BCS followed by hypofractionated WBRT in 16 fractions for a total dose of 42.5 Gy (2.66 Gy per fraction). Boost RT to the surgical bed was given to 125 patients (28%) at a median dose of 10 Gy in 4 fractions (2.5 Gy per fraction). After a median follow-up time of 4.4 years, 14 patients had an ipsilateral local relapse, resulting in a local recurrence-free survival of 97% at 5 years. Positive surgical margins, high nuclear grade, age less than 50 years, and a premenopausal status were all statistically associated with an increased occurrence of local recurrence. Tumor hormone receptor status, use of adjuvant hormonal therapy, and administration of additional boost RT did not have an impact on local control in our cohort. On multivariate analysis, positive margins, premenopausal status, and nuclear grade 3 tumors had a statistically significant worse local control rate. Conclusions: Hypofractionated RT using 42.5 Gy in 16 fractions provides excellent local control for patients with DCIS undergoing BCS.

  6. Radiation Therapy After Breast-Conserving Surgery: Does Hospital Surgical Volume Matter? A Population-Based Study in Taiwan

    SciTech Connect (OSTI)

    Chien, Chun-Ru [Section of Health Services Research, Department of Biostatistics, Division of Quantitative Sciences, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Department of Radiation Oncology, China Medical University Hospital, and School of Medicine, China Medical University, Taichung, Taiwan (China); Pan, I-Wen [Section of Health Services Research, Department of Biostatistics, Division of Quantitative Sciences, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Tsai, Yi-Wen [Center of Health Policy Research and Development, National Health Research Institutes, Miaoli County, Taiwan (China); Institute of Health and Welfare Policy, National Yang-Ming University Hospital, Taipei, Taiwan (China); Tsai, Teressa [Center of Health Policy Research and Development, National Health Research Institutes, Miaoli County, Taiwan (China); Liang, Ji-An [Department of Radiation Oncology, China Medical University Hospital, and School of Medicine, China Medical University, Taichung, Taiwan (China); Buchholz, Thomas A. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Shih, Ya-Chen Tina, E-mail: yashih@mdanderson.org [Section of Health Services Research, Department of Biostatistics, Division of Quantitative Sciences, University of Texas MD Anderson Cancer Center, Houston, TX (United States)

    2012-01-01T23:59:59.000Z

    Purpose: To examine the association between hospital surgical volume and the use of radiation therapy (RT) after breast-conserving surgery (BCS) in Taiwan. Methods and Materials: We used claims data from the National Health Insurance program in Taiwan (1997-2005) in this retrospective population-based study. We identified patients with breast cancer, receipt of BCS, use of radiation, and the factors that could potentially associated with the use of RT from enrollment records, and the ICD-9 and billing codes in claims. We conducted logistic regression to examine factors associated with RT use after BCS, and performed subgroup analyses to examine whether the association differs by medical center status or hospital volumes. Results: Among 5,094 patients with newly diagnosed invasive breast cancer who underwent BCS, the rate of RT was significantly lower in low-volume hospitals (74% vs. 82%, p < 0.01). Patients treated in low-volume hospitals were less likely to receive RT after BCS (odds ratio = 0.72, 95% confidence interval = 0.62-0.83). In addition, patients treated after the implementation of the voluntary pay-for-performance policy in 2001 were more likely to receive RT (odds ratio = 1.23; 95% confidence interval = 1.05-1.45). Subgroup analyses indicated that the high-volume effect was limited to hospitals accredited as non-medical centers, and that the effect of the pay-for-performance policy was most pronounced among low-volume hospitals. Conclusions: Using population-based data from Taiwan, our study concluded that hospital surgical volume and pay-for-performance policy are positively associated with RT use after BCS.

  7. In-Born Radio Frequency Identification Devices for Safeguards Use at Gas-Centrifuge Enrichment Plants

    SciTech Connect (OSTI)

    Ward,R.; Rosenthal,M.

    2009-07-12T23:59:59.000Z

    Global expansion of nuclear power has made the need for improved safeguards measures at Gas Centrifuge Enrichment Plants (GCEPs) imperative. One technology under consideration for safeguards applications is Radio Frequency Identification Devices (RFIDs). RFIDs have the potential to increase IAEA inspector"s efficiency and effectiveness either by reducing the number of inspection visits necessary or by reducing inspection effort at those visits. This study assesses the use of RFIDs as an integral component of the "Option 4" safeguards approach developed by Bruce Moran, U.S. Nuclear Regulatory Commission (NRC), for a model GCEP [1]. A previous analysis of RFIDs was conducted by Jae Jo, Brookhaven National Laboratory (BNL), which evaluated the effectiveness of an RFID tag applied by the facility operator [2]. This paper presents a similar evaluation carried out in the framework of Jos paper, but it is predicated on the assumption that the RFID tag is applied by the manufacturer at the birth of the cylinder, rather than by the operator. Relevant diversion scenarios are examined to determine if RFIDs increase the effectiveness and/ or efficiency of safeguards in these scenarios. Conclusions on the benefits offered to inspectors by using in-born RFID tagging are presented.

  8. Cardiac Mortality in Patients With Stage I and II Diffuse Large B-Cell Lymphoma Treated With and Without Radiation: A Surveillance, Epidemiology, and End-Results Analysis

    SciTech Connect (OSTI)

    Pugh, Thomas J., E-mail: thomas.pugh@ucdenver.ed [Department of Radiation Oncology, University of Colorado Comprehensive Cancer Center, Aurora, Colorado (United States); Ballonoff, Ari; Rusthoven, Kyle E.; McCammon, Robert; Kavanagh, Brian; Newman, Francis; Rabinovitch, Rachel [Department of Radiation Oncology, University of Colorado Comprehensive Cancer Center, Aurora, Colorado (United States)

    2010-03-01T23:59:59.000Z

    Purpose: Standard therapy for stage I and II diffuse large B-cell lymphoma consists of combined modality therapy with anthracycline-based chemotherapy, anti-CD20 antibody, and radiation therapy (RT). Curative approaches without RT typically utilize more intensive and/or protracted chemotherapy schedules. Anthracycline-based chemotherapy regimens are associated with a dose-dependent risk of left ventricular systolic dysfunction. We hypothesize that patients treated without RT, i.e., those who are treated with greater total chemotherapy cycles and hence cumulative anthracycline exposure, are at increased risk of cardiac mortality. Methods and Materials: The rate of cardiac-specific mortality (CSM) was analyzed in patients with stage I and II diffuse large B-cell lymphoma diagnosed between 1988 and 2004 by querying the National Cancer Institute Surveillance, Epidemiology, and End-Results database. Analyzable data included gender, age, race, stage, presence of extranodal disease, and RT administration. Results: A total of 15,454 patients met selection criteria; 6,021 (39%) patients received RT. The median follow-up was 36 months (range, 6-180 months). The median age was 64 years. The actuarial incidence rates of CSM at 5, 10, and 15 years were 4.3%, 9.0%, and 13.8%, respectively, in patients treated with RT vs. 5.9%, 10.8% and 16.1%, respectively, in patients treated without RT (p < 0.0001; hazard ratio, 1.35; 95% confidence interval [CI]: 1.16-1.56). The increase in cardiac deaths for patients treated without RT persisted throughout the follow-up period. On multivariate analysis, treatment without RT remained independently associated with an increased risk of CSM (Cox hazard ratio, 1.32; 95% CI: 1.13-1.54; p = 0.0005). Conclusions: Increased anthracycline exposure in patients treated only with chemotherapy regimens may result in an increase in cardiac deaths, detectable only through analysis of large sample sizes. Confirmatory evaluation through meta-analysis of randomized data and design of large prospective trials is warranted.

  9. The influence of the spectral emissivity of flat-plate calibrators on the calibration of IR thermometers

    SciTech Connect (OSTI)

    Crdenas-Garca, D.; Mndez-Lango, E. [Centro Nacional de Metrologa, CENAM Km 4.5 Carretera a los Cus, El Marqus, Quertaro, 76246 (Mexico)] [Centro Nacional de Metrologa, CENAM Km 4.5 Carretera a los Cus, El Marqus, Quertaro, 76246 (Mexico)

    2013-09-11T23:59:59.000Z

    Flat Calibrators (FC) are an option for calibration of infrared thermometers (IT) with a fixed large target. FCs are neither blackbodies, nor gray-bodies; their spectral emissivity is lower than one and depends on wavelength. Nevertheless they are used as gray-bodies with a nominal emissivity value. FCs can be calibrated radiometrically using as reference a calibrated IR thermometer (RT). If an FC will be used to calibrate ITs that work in the same spectral range as the RT then its calibration is straightforward: the actual FC spectral emissivity is not required. This result is valid for any given fixed emissivity assessed to the FC. On the other hand, when the RT working spectral range does not match with that of the ITs to be calibrated with the FC then it is required to know the FC spectral emissivity as part of the calibration process. For this purpose, at CENAM, we developed an experimental setup to measure spectral emissivity in the infrared spectral range, based on a Fourier transform infrared spectrometer. Not all laboratories have emissivity measurement capability in the appropriate wavelength and temperature ranges to obtain the spectral emissivity. Thus, we present an estimation of the error introduced when the spectral range of the RT used to calibrate an FC and the spectral ranges of the ITs to be calibrated with the FC do not match. Some examples are developed for the cases when RT and IT spectral ranges are [8,13] ?m and [8,14] ?m respectively.

  10. Dentofacial development in long-term survivors of acute lymphoblastic leukemia. A comparison of three treatment modalities

    SciTech Connect (OSTI)

    Sonis, A.L.; Tarbell, N.; Valachovic, R.W.; Gelber, R.; Schwenn, M.; Sallan, S. (Children's Hospital, Boston, MA (USA))

    1990-12-15T23:59:59.000Z

    Ninety-seven children who were diagnosed with acute lymphoblastic leukemia before 10 years of age and treated with chemotherapy alone, chemotherapy plus 1800-cGy cranial irradiation (RT), or chemotherapy plus 2400-cGy RT were evaluated for effects of therapy on dentofacial development. All patients were seen at least 5 years postdiagnosis. Dental abnormalities were determined from panoramic radiographs, and craniofacial evaluations were made from lateral cephalometric radiographs. Ninety-one (94%) of all patients and 41 (100%) of patients younger than 5 years of age at diagnosis had abnormal dental development. The severity of these abnormalities was greater in children who received treatment before 5 years of age and in those who received RT. Observed dental abnormalities included tooth agenesis, arrested root development, microdontia, and enamel dysplasias. Craniofacial abnormalities occurred in 18 of 20 (90%) of those patients who received chemotherapy plus 2400-cGy RT before 5 years of age. Mean cephalometric values of this group showed significant deficient mandibular development. The results of this study suggest that the severity of dentofacial-developmental abnormalities secondary to antileukemia therapy are related to the age of the patient at the initiation of treatment and the use of cranial RT.

  11. The role of helium implantation induced vacancy defect on hardening of tungsten

    SciTech Connect (OSTI)

    Ou, Xin, E-mail: x.ou@hzdr.de [Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstr. 400, 01328 Dresden (Germany); State Key Laboratory of Functional Material for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200250 (China); Anwand, Wolfgang, E-mail: w.anwand@hzdr.de; Kgler, Reinhard, E-mail: r.koegler@hzdr.de [Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstr. 400, 01328 Dresden (Germany); Zhou, Hong-Bo [Department of Physics, Beihang University, Beijing 100191 (China); Richter, Asta, E-mail: asta.richter@th-wildau.de [Technische Hochschule Wildau, Hochschulring1, 15745 Wildau (Germany)

    2014-03-28T23:59:59.000Z

    Vacancy-type defects created by helium implantation in tungsten and their impact on the nano-hardness characteristics were investigated by correlating the results from the positron annihilation spectroscopy and the nano-indentation technique. Helium implantation was performed at room temperature (RT) and at an elevated temperate of 600?C. Also, the effect of post-annealing of the RT implanted sample was studied. The S parameter characterizing the open volume in the material was found to increase after helium irradiation and is significantly enhanced for the samples thermally treated at 600?C either by irradiation at high temperature or by post-annealing. Two types of helium-vacancy defects were detected after helium irradiation; small defects with high helium-to-vacancy ratio (low S parameter) for RT irradiation and large defects with low helium-to-vacancy ratio (high S parameter) for thermally treated tungsten. The hardness of the heat treated tungsten coincides with the S parameter, and hence is controlled by the large helium-vacancy defects. The hardness of tungsten irradiated at RT without thermal treatment is dominated by manufacturing related defects such as dislocation loops and impurity clusters and additionally by trapped He atoms from irradiation effects, which enhance hardness. He-stabilized dislocation loops mainly cause the very high hardness values in RT irradiated samples without post-annealing.

  12. High-energy limit of collision-induced false vacuum decay

    E-Print Network [OSTI]

    Sergei Demidov; Dmitry Levkov

    2015-03-21T23:59:59.000Z

    We develop a consistent semiclassical description of field-theoretic collision-induced tunneling at arbitrary high energies. As a playground we consider a (1+1)-dimensional false vacuum decay accompanied by N-particle collisions at energy E. The semiclassical suppression exponent F_N(E) of this process is computed numerically at N>>1 and extrapolated to N=2 with the aid of the Rubakov-Son-Tinyakov conjecture. Our method is based on a specific behavior of F_N(E): it decreases with energy, reaches minimum F=F_{min}(N) at E=E_{rt}(N) and stays constant at higher energies. The respective cross section is exponentially suppressed at all energies. This behavior is numerically observed in the (1+1)-dimensional model and conjectured to be general. We show that F_{min}(N) and E_{rt}(N) are evaluated using a special class of complex semiclassical solutions which describe exponentially suppressed transitions but nevertheless evolve in real time. Importantly, we argue that the collision-induced transitions with N=2 initial particles can be described perturbatively at E>E_{rt}(2) in the background of these solutions, and the terms of the perturbative expansion remain bounded in the high-energy limit. Transitions in the latter regime involve emission of many soft quanta with total energy E_{rt}(2) by the two colliding particles; the energy excess E-E_{rt}(2) remains in the initial particles till the end of the process.

  13. A survey of methods concerning the effects of impurities on the thermophysical properties of pure components

    E-Print Network [OSTI]

    Phillips, Tony Lee

    1980-01-01T23:59:59.000Z

    and the r esu' ts compared to measurements . Table 1. DOS Used to Determine the Dew-Rubble Gap. v d'I(1 P =R /! v-b) - a/ v a=?7R /(64P ) 2 2 b=RT /(8P ) C C P=R /( , v-b)-a/I v( v+b) ] a=O. 42747F, T P b=0. 08664RT /P C C SRK P=RT/( v ? b...)-a/[v( v+b) ] a=O. 42747R . s /P s=1+(0. 480+1 . 574w-0. 176~ ) (1 ? ' ) 2 1/2 b=0. 08664RT /P C C PR P=R /( v-b) ? a/[v( v ? b)+b( v-b) ] a=O. 45724(R T /. ) t C C t=1+(0. 37464+1. 54226m-0. 2699m ) (1- ?) 2 1/2 b=0. 07780RT /P C C I D '. A L S Y...

  14. Effects of laser energy fluence on the onset and growth of the Rayleigh-Taylor instabilities and its influence on the topography of the Fe thin film grown in pulsed laser deposition facility

    SciTech Connect (OSTI)

    Mahmood, S. [National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore 637616 (Singapore); Department of Physics, University of Karachi, Karachi 75270 (Pakistan); Rawat, R. S.; Wang, Y.; Lee, S.; Tan, T. L.; Springham, S. V.; Lee, P. [National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore 637616 (Singapore); Zakaullah, M. [Department of Physics, Quaid-i-Azam University, 45320 Islamabad (Pakistan)

    2012-10-15T23:59:59.000Z

    The effect of laser energy fluence on the onset and growth of Rayleigh-Taylor (RT) instabilities in laser induced Fe plasma is investigated using time-resolved fast gated imaging. The snow plow and shock wave models are fitted to the experimental results and used to estimate the ablation parameters and the density of gas atoms that interact with the ablated species. It is observed that RT instability develops during the interface deceleration stage and grows for a considerable time for higher laser energy fluence. The effects of RT instabilities formation on the surface topography of the Fe thin films grown in pulsed laser deposition system are investigated (i) using different laser energy fluences for the same wavelength of laser radiation and (ii) using different laser wavelengths keeping the energy fluence fixed. It is concluded that the deposition achieved under turbulent condition leads to less smooth deposition surfaces with bigger sized particle agglomerates or network.

  15. Dynamic system characterization of an integral test facility of an advanced PWR

    E-Print Network [OSTI]

    Smith, Simon Gregory

    1995-01-01T23:59:59.000Z

    gives: P = pph&+p gh + p RT Differentiating with respect to time leads to, dp dp/ dhf dp dh dp gh. + p g ? + ? gh + p g ? s+ ? sRT+ p R? dt dt t / dt d? s dt dt t dt For a fixed tank with area A, -dhf/dt can be substituted for dhs/dt, and (H - hf...) for hs, dp dp/ dh/ dp dh& dp dT gh + pg ? + ? sg(H ? h) ? p g ? + ? RT+ p R? dt dt / /g dt dt / s dt dt & dt (] 2) 16 Since pt is approximately constant, or changes very slowly compared to other dynamic changes in the system: dpf Substituting...

  16. Electron Scattering in InSb Quantum Wells due to Micro-twin Defects

    SciTech Connect (OSTI)

    Mishima, T. D.; Santos, M. B. [Homer L. Dodge Department of Physics and Astronomy, and Center for Semiconductor Physics in Nanostructure University of Oklahoma, 440 W. Brooks St., Norman, OK 73019 (United States)

    2011-12-26T23:59:59.000Z

    The transport electron scattering due to micro-twin (MT) defects in InSb quantum wells (QWs) has been investigated at room temperature (RT). A linear-regression-based scattering analysis showed that Matthiessen's rule is applicable to the RT electron mobility in 20-nm-thick InSb QWs that contain MTs (whose density is 5.6x10{sup 2}-1.2x10{sup 4} /cm) and threading dislocations (8.7x10{sup 8}-3.2x10{sup 9} /cm{sup 2}) as dominant structural defects. For such an InSb QW whose local electron mobility in its non-MT regions is 2.8x10{sup 4}-4.5x10{sup 4} cm{sup 2}/(Vs), the MT-originated energy barrier against the electron transport is deduced to be 0.081-0.093 eV at RT.

  17. Final Report - ILAW PCT, VHT, Viscosity, and Electrical Conductivity Model Development, VSL-07R1230-1

    SciTech Connect (OSTI)

    Kruger, Albert A.; Cooley, S. K.; Joseph, I.; Pegg, I. L.; Piepel, G. F.; Gan, H.; Muller, I.

    2013-12-17T23:59:59.000Z

    This report describes the results of work and testing specified by the Test Specifications (24590-LAW-TSP-RT-01-013 Rev.1 and 24590-WTP-TSP-RT-02-001 Rev.0), Test Plans (VSL-02T4800-1 Rev.1 & TP-RPP-WTP-179 Rev.1), and Text Exception (24590-WTP-TEF-RT-03-040). The work and any associated testing followed established quality assurance requirements and conducted as authorized. The descriptions provided in this test report are an accurate account of both the conduct of the work and the data collected. Results required by the Test Plans are reported. Also reported are any unusual or anomalous occurrences that are different from the starting hypotheses. The test results and this report have been reviewed and verified.

  18. Investigation of forced and isothermal chemical vapor infiltrated SiC/SiC ceramic matrix composites. Final report

    SciTech Connect (OSTI)

    Sankar, J.; Kelkar, A.D.; Vaidyanathan, R. [North Carolina Agricultural and Technical State Univ., Greensboro, NC (United States). Dept. of Mechanical Engineering

    1993-09-01T23:59:59.000Z

    Mechanical properties of two different layups for each of the forced CVI (41 specimens) and isothermal CVI (36 specimens) materials were investigated in air at room temperature (RT), 1000C, and at room temperature after thermal shock (RT/TS) and exposure to oxidation (RT/OX). The FCVI specimens had a nominal interfacial coating thickness of 0.3 {mu}m of pyrolytic carbon, while CVI specimens had a coating thickness of 0.1 {mu}m. Effect of reinforcement and interfacial bond on mechanical properties of composite were investigated. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were employed to analyze the fiber-matrix interface and the toughening mechanisms in this ceramic composite system.

  19. Correlations Among Gender, Career Interests, Conservation Issues, And Curriculum Choice By Students In Wildlife And Fisheries Sciences At Texas A&M University From 2000 To 2008

    E-Print Network [OSTI]

    Woldhagen, Ashley N.

    2010-10-12T23:59:59.000Z

    due to complying with the law protecting endangered species. PplMnWL People have the right to manage wildlife populations. WLtoAll Wildlife belong to all people, even if found on private land. BredHnt It is ok to breed and raise wildlife (deer...ProN ESReimbA ESReimbD ESReimbN PplMnWLA PplMnWLD PplMnWLN WLtoAllA WLtoAllD WLtoAllN BredHntA BredHntD BredHntN GvRgOcnA GvRgOcnD GvRgOcnN SanctGvA SanctGvD SanctGvN WLPetA WLPetD WLPetN FshCrulA FshCrulD FshCrulN AnRt.PpA AnRt.PpD AnRt.PpN 2000 2008 Male...

  20. Study of RayleighTaylor growth in laser irradiated planar SiO{sub 2} targets at ignition-relevant conditions

    SciTech Connect (OSTI)

    Hager, J. D.; Collins, T. J. B.; Knauer, J. P.; Meyerhofer, D. D.; Sangster, T. C. [Laboratory for Laser Energetics, University of Rochester, 250 East River Road, Rochester, New York 14623-1299 (United States)] [Laboratory for Laser Energetics, University of Rochester, 250 East River Road, Rochester, New York 14623-1299 (United States); Smalyuk, V. A. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States)] [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States)

    2013-07-15T23:59:59.000Z

    RayleighTaylor (RT) growth experiments were performed on the OMEGA laser [T. R. Boehly et al., Opt. Commun. 133, 495 (1997)] using planar SiO{sub 2} targets seeded with a single mode 60-?m wavelength perturbation driven at peak laser intensities up to 9 10{sup 14} W/cm{sup 2}. These are the first RT measurements in SiO{sub 2} at conditions relevant to direct-drive inertial confinement fusion ignition. The measured average modulation growth rates agree with the 2-D hydrodynamics code DRACO, providing an important step in the development of target ablators that are robust to RT growth and hot- electron preheat considerations when driven at the intensities required to achieve thermonuclear ignition.

  1. Toxic species emissions from controlled combustion of selected rubber and plastic consumer products

    E-Print Network [OSTI]

    Caraballo, Simon A.

    1992-01-01T23:59:59.000Z

    . . . . . . . . . . . . . . . . . . . . . APPENDIX B Effects of Humidity on Ashes of U-S3 Rubber vs. PVC. APPENDIX C SAS Program for ANOVA. APPENDIX D Comparison of the Burning Rates for Materials V-S I, C-S2, U-S3 and RT-S5. VITA. PAGE 91 93 102 103 LIST OF TABLES TABLE 1. Comparison..., B, and C) Versus Rubber ~s V-SI, C-S2, U-S3 and RT-S5 fro this Study. . . . . . . . . . . . . . . . . . . 50 TABLE 11-B ANOVA - Percentage Smoke-Mass Based on Initial Sample Weight for hLdn&s V-S1, C-S2, U-S3, RT- S5, PVC-A, PVC-B and PVC-C...

  2. Three-dimensional Radiative Transfer with Multilevel Atoms

    E-Print Network [OSTI]

    P. Fabiani Bendicho; J. Trujillo Bueno

    2007-10-29T23:59:59.000Z

    The efficient numerical solution of Non-LTE multilevel transfer problems requires the combination of highly convergent iterative schemes with fast and accurate formal solution methods of the radiative transfer (RT) equation. This contribution begins presenting a method for the formal solution of the RT equation in three-dimensional (3D) media with horizontal periodic boundary conditions. This formal solver is suitable for both, unpolarized and polarized 3D radiative transfer and it can be easily combined with the iterative schemes for solving non-LTE multilevel transfer problems that we have developed over the last few years. We demonstrate this by showing some schematic 3D multilevel calculations that illustrate the physical effects of horizontal radiative transfer. These Non-LTE calculations have been carried out with our code MUGA 3D, a 3D multilevel Non-LTE code based on the Gauss-Seidel iterative scheme that Trujillo Bueno and Fabiani Bendicho (1995) developed for RT applications.

  3. Surgery Followed by Radiotherapy Versus Radiotherapy Alone for Metastatic Spinal Cord Compression From Unfavorable Tumors

    SciTech Connect (OSTI)

    Rades, Dirk, E-mail: Rades.Dirk@gmx.net [Department of Radiation Oncology, University of Lubeck (Germany); Huttenlocher, Stefan [Department of Radiation Oncology, University of Lubeck (Germany); Bajrovic, Amira [Department of Radiation Oncology, University Medical Center Hamburg-Eppendorf (Germany); Karstens, Johann H. [Department of Radiation Oncology, Medical University Hannover (Germany); Adamietz, Irenaeus A. [Department of Radiation Oncology, Ruhr University Bochum (Germany); Kazic, Nadja [Department of Radiation Oncology, University of Sarajevo (Bosnia and Herzegowina); Rudat, Volker [Department of Radiation Oncology, Saad Specialist Hospital Al Khobar (Saudi Arabia); Schild, Steven E. [Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ (United States)

    2011-12-01T23:59:59.000Z

    Purpose: Despite a previously published randomized trial, controversy exists regarding the benefit of adding surgery to radiotherapy for metastatic spinal cord compression (MSCC). It is thought that patients with MSCC from relatively radioresistant tumors or tumors associated with poor functional outcome after radiotherapy alone may benefit from surgery. This study focuses on these tumors. Methods and Materials: Data from 67 patients receiving surgery plus radiotherapy (S+RT) were matched to 134 patients (1:2) receiving radiotherapy alone (RT). Groups were matched for 10 factors and compared for motor function, ambulatory status, local control, and survival. Additional separate matched-pair analyses were performed for patients receiving direct decompressive surgery plus stabilization of involved vertebrae (DDSS) and patients receiving laminectomy (LE). Results: Improvement of motor function occurred in 22% of patients after S+RT and 16% after RT (p = 0.25). Posttreatment ambulatory rates were 67% and 61%, respectively (p = 0.68). Of nonambulatory patients, 29% and 19% (p = 0.53) regained ambulatory status. One-year local control rates were 85% and 89% (p = 0.87). One-year survival rates were 38% and 24% (p = 0.20). The matched-pair analysis of patients receiving LE showed no significant differences between both therapies. In the matched-pair analysis of patients receiving DDSS, improvement of motor function occurred more often after DDSS+RT than RT (28% vs. 19%, p = 0.024). Posttreatment ambulatory rates were 86% and 67% (p = 0.30); 45% and 18% of patients regained ambulatory status (p = 0.29). Conclusions: Patients with MSCC from an unfavorable primary tumor appeared to benefit from DDSS but not LE when added to radiotherapy in terms of improved functional outcome.

  4. Pulsed Versus Conventional Radiation Therapy in Combination With Temozolomide in a Murine Orthotopic Model of Glioblastoma Multiforme

    SciTech Connect (OSTI)

    Lee, David Y.; Chunta, John L.; Park, Sean S.; Huang, Jiayi; Martinez, Alvaro A.; Grills, Inga S.; Krueger, Sarah A.; Wilson, George D. [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan (United States); Marples, Brian, E-mail: brian.marples@beaumont.edu [Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan (United States)

    2013-08-01T23:59:59.000Z

    Purpose: To evaluate the efficacy of pulsed low-dose radiation therapy (PLRT) combined with temozolomide (TMZ) as a novel treatment approach for radioresistant glioblastoma multiforme (GBM) in a murine model. Methods and Materials: Orthotopic U87MG hGBM tumors were established in Nu-Foxn1{sup nu} mice and imaged weekly using a small-animal micropositron emission tomography (PET)/computed tomography (CT) system. Tumor volume was determined from contrast-enhanced microCT images and tumor metabolic activity (SUVmax) from the F18-FDG microPET scan. Tumors were irradiated 7 to 10 days after implantation with a total dose of 14 Gy in 7 consecutive days. The daily treatment was given as a single continuous 2-Gy dose (RT) or 10 pulses of 0.2 Gy using an interpulse interval of 3 minutes (PLRT). TMZ (10 mg/kg) was given daily by oral gavage 1 hour before RT. Tumor vascularity and normal brain damage were assessed by immunohistochemistry. Results: Radiation therapy with TMZ resulted in a significant 3- to 4-week tumor growth delay compared with controls, with PLRT+TMZ the most effective. PLRT+TMZ resulted in a larger decline in SUVmax than RT+TMZ. Significant differences in survival were evident. Treatment after PLRT+TMZ was associated with increased vascularization compared with RT+TMZ. Significantly fewer degenerating neurons were seen in normal brain after PLRT+TMZ compared with RT+TMZ. Conclusions: PLRT+TMZ produced superior tumor growth delay and less normal brain damage when compared with RT+TMZ. The differential effect of PLRT on vascularization may confirm new treatment avenues for GBM.

  5. A prospective study on radiation-induced changes in hearing function

    SciTech Connect (OSTI)

    Herrmann, Franziska [Department of Oto-Rhino-Laryngology, University of Technology-Dresden, Dresden (Germany); Doerr, Wolfgang [Department of Radiotherapy and Radiation Oncology, University of Technology-Dresden, Dresden (Germany); Experimental Center, Medical Faculty Carl Gustav Carus, University of Technology-Dresden, Dresden (Germany); Mueller, Rainer [Department of Oto-Rhino-Laryngology, University of Technology-Dresden, Dresden (Germany); Herrmann, Thomas [Department of Radiotherapy and Radiation Oncology, University of Technology-Dresden, Dresden (Germany)]. E-mail: thomas.herrmann@mailbox.tu-dresden.de

    2006-08-01T23:59:59.000Z

    Purpose: To quantitate changes in hearing function after radiotherapy for head-and-neck tumors. Methods and Materials: At the Department of Radiotherapy and Radiation Oncology, 32 patients were irradiated for head-and-neck tumors. Three-dimensional treatment planning was applied. Total tumor doses were 30.0-77.6 Gy, local doses to the inner ear (n = 64) ranged from 1.7 to 64.3 Gy. Audiometry was performed before the onset of radiotherapy (RT), at a tumor dose of 40 Gy or at the end of palliative treatment, at the end of curative RT, and 2-6 months post-RT. Assays applied were frequency-specific threshold measurements for air and bone conduction, measurements according to Weber and Rinne, tympanometry and assessment of the stapedius reflex. Results: Age and prior disease significantly decreased, whereas previous or concurrent alcohol consumption significantly increased hearing ability. A significant reduction in hearing ability during RT was found for high frequencies (at 40 Gy) and low frequencies (at end of RT), which persisted after RT. No differences were observed for air or bone conduction. None of the other assays displayed time- or dose-dependent changes. Dose-effect analyses revealed an ED50 (dose at which a 50% incidence is expected) for significant changes in hearing thresholds (15 dB) in the range of 20-25 Gy, with large confidence limits. Conclusions: Radiation effects on hearing ability were confined to threshold audiogram values, which started during the treatment without reversibility during 6 months postradiotherapy.

  6. Decision Regret in Men Undergoing Dose-Escalated Radiation Therapy for Prostate Cancer

    SciTech Connect (OSTI)

    Steer, Anna N. [Department of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour (Australia)] [Department of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour (Australia); Aherne, Noel J., E-mail: noel.aherne@ncahs.health.nsw.gov.au [Department of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour (Australia); Rural Clinical School Faculty of Medicine, University of New South Wales, Coffs Harbour (Australia); Gorzynska, Karen; Hoffman, Matthew; Last, Andrew; Hill, Jacques [Department of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour (Australia)] [Department of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour (Australia); Shakespeare, Thomas P. [Department of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour (Australia) [Department of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour (Australia); Rural Clinical School Faculty of Medicine, University of New South Wales, Coffs Harbour (Australia)

    2013-07-15T23:59:59.000Z

    Purpose: Decision regret (DR) is a negative emotion associated with medical treatment decisions, and it is an important patient-centered outcome after therapy for localized prostate cancer. DR has been found to occur in up to 53% of patients treated for localized prostate cancer, and it may vary depending on treatment modality. DR after modern dose-escalated radiation therapy (DE-RT) has not been investigated previously, to our knowledge. Our primary aim was to evaluate DR in a cohort of patients treated with DE-RT. Methods and Materials: We surveyed 257 consecutive patients with localized prostate cancer who had previously received DE-RT, by means of a validated questionnaire. Results: There were 220 responses (85.6% response rate). Image-guided intensity modulated radiation therapy was given in 85.0% of patients and 3-dimensional conformal radiation therapy in 15.0%. Doses received included 73.8 Gy (34.5% patients), 74 Gy (53.6%), and 76 Gy (10.9%). Neoadjuvant androgen deprivation (AD) was given in 51.8% of patients and both neoadjuvant and adjuvant AD in 34.5%. The median follow-up time was 23 months (range, 12-67 months). In all, 3.8% of patients expressed DR for their choice of treatment. When asked whether they would choose DE-RT or AD again, only 0.5% probably or definitely would not choose DE-RT again, compared with 8.4% for AD (P<.01). Conclusion: Few patients treated with modern DE-RT express DR, with regret appearing to be lower than in previously published reports of patients treated with radical prostatectomy or older radiation therapy techniques. Patients experienced more regret with the AD component of treatment than with the radiation therapy component, with implications for informed consent. Further research should investigate regret associated with individual components of modern therapy, including AD, radiation therapy and surgery.

  7. Intensity Modulated Radiation Therapy With Dose Painting to Treat Rhabdomyosarcoma

    SciTech Connect (OSTI)

    Yang, Joanna C.; Dharmarajan, Kavita V. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)] [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Wexler, Leonard H. [Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)] [Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); La Quaglia, Michael P. [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)] [Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Happersett, Laura [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)] [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Wolden, Suzanne L., E-mail: woldens@mskcc.org [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)

    2012-11-01T23:59:59.000Z

    Purpose: To examine local control and patterns of failure in rhabdomyosarcoma patients treated with intensity modulated radiation therapy (RT) with dose painting (DP-IMRT). Patients and Methods: A total of 41 patients underwent DP-IMRT with chemotherapy for definitive treatment. Nineteen also underwent surgery with or without intraoperative RT. Fifty-six percent had alveolar histologic features. The median interval from beginning chemotherapy to RT was 17 weeks (range, 4-25). Very young children who underwent second-look procedures with or without intraoperative RT received reduced doses of 24-36 Gy in 1.4-1.8-Gy fractions. Young adults received 50.4 Gy to the primary tumor and lower doses of 36 Gy in 1.8-Gy fractions to at-risk lymph node chains. Results: With 22 months of median follow-up, the actuarial local control rate was 90%. Patients aged {<=}7 years who received reduced overall and fractional doses had 100% local control, and young adults had 79% (P=.07) local control. Three local failures were identified in young adults whose primary target volumes had received 50.4 Gy in 1.8-Gy fractions. Conclusions: DP-IMRT with lower fractional and cumulative doses is feasible for very young children after second-look procedures with or without intraoperative RT. DP-IMRT is also feasible in adolescents and young adults with aggressive disease who would benefit from prophylactic RT to high-risk lymph node chains, although dose escalation might be warranted for improved local control. With limited follow-up, it appears that DP-IMRT produces local control rates comparable to those of sequential IMRT in patients with rhabdomyosarcoma.

  8. Postoperative Single-Fraction Radiation for Prevention of Heterotopic Ossification of the Elbow

    SciTech Connect (OSTI)

    Robinson, Clifford G. [Department of Radiation Oncology, Cleveland Clinic, Cleveland, Ohio (United States); Polster, Joshua M. [Department of Radiology, Cleveland Clinic, Cleveland, Ohio (United States); Reddy, Chandana A. [Department of Radiation Oncology, Cleveland Clinic, Cleveland, Ohio (United States); Lyons, Janice A. [Department of Radiation Oncology, UH Case Medical Center, Cleveland, Ohio (United States); Evans, Peter J.; Lawton, Jeffrey N. [Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio (United States); Graham, Thomas J. [Curtis National Hand Center, Baltimore, Maryland (United States); Suh, John H., E-mail: suhj@ccf.or [Department of Radiation Oncology, Cleveland Clinic, Cleveland, Ohio (United States)

    2010-08-01T23:59:59.000Z

    Purpose: Heterotopic ossification (HO) about the elbow has been described after surgery, trauma, and burns. Even limited deposits can lead to significant functional deficits. Little data exist regarding outcomes of patients treated with radiation therapy (RT) after elbow surgery. We report here the Cleveland Clinic experience with single-fraction radiation following surgery to the elbow. The primary endpoint was the rate of new HO after RT. Secondary endpoints were range of motion, functional compromise, and toxicity. Methods and Materials: From May 1993 to July 2006, 36 patients underwent elbow surgery followed by single-fraction RT. Range of motion data were collected before and during surgery and at last follow-up. Radiographs were reviewed for persistent or new HO. Patient and treatment factors were analyzed for correlation with development of HO or functional compromise. Results: Median follow-up was 8.7 months, median age was 42 years, and 75% of patients were male. Twenty-six (72%) patients had HO prior to surgery. All patients had significant limitations in flexion/extension or pronation/supination at baseline. Thirty-one (86%) patients had prior elbow trauma, and 26 (72%) patients had prior surgery. RT was administered a median of 1 day postoperatively (range, 1-4 days). Thirty-four patients received 700 cGy, and 2 patients received 600 cGy. Three (8%) patients developed new HO after RT. All patients had improvement in range of motion from baseline. No patient or treatment factors were significantly associated with the development of HO or functional compromise. Conclusions: Single-fraction RT after surgery to the elbow is associated with favorable functional and radiographic outcomes.

  9. Outcomes of Patients With Revised Stage I Clear Cell Sarcoma of Kidney Treated in National Wilms Tumor Studies 1-5

    SciTech Connect (OSTI)

    Kalapurakal, John A., E-mail: j-kalapurakal@northwestern.edu [Northwestern University, Chicago, Illinois (United States); Perlman, Elizabeth J. [Northwestern University, Chicago, Illinois (United States)] [Northwestern University, Chicago, Illinois (United States); Seibel, Nita L. [Cancer Therapy and Evaluation Program, Bethesda, Maryland (United States)] [Cancer Therapy and Evaluation Program, Bethesda, Maryland (United States); Ritchey, Michael [Phoenix Children's Hospital, Phoenix, Arizona (United States)] [Phoenix Children's Hospital, Phoenix, Arizona (United States); Dome, Jeffrey S. [Children's National Medical Center, Washington, District of Columbia (United States)] [Children's National Medical Center, Washington, District of Columbia (United States); Grundy, Paul E. [University of Alberta, Edmonton, AB (Canada)] [University of Alberta, Edmonton, AB (Canada)

    2013-02-01T23:59:59.000Z

    Purpose: To report the clinical outcomes of children with revised stage I clear cell sarcoma of the kidney (CCSK) using the National Wilms Tumor Study Group (NWTS)-5 staging criteria after multimodality treatment on NWTS 1-5 protocols. Methods and Materials: All CCSK patients enrolled in the National Wilms Tumor Study Group protocols had their pathology slides reviewed, and only those determined to have revised stage I tumors according to the NWTS-5 staging criteria were included in the present analysis. All patients were treated with multimodality therapy according to the NWTS 1-5 protocols. Results: A total of 53 children were identified as having stage I CCSK. All patients underwent primary surgery with radical nephrectomy. The chemotherapy regimens used were as follows: regimen A, C, F, or EE in 4 children (8%); regimen DD or DD4A in 33 children (62%); regimen J in 4 children (8%); and regimen I in 12 children (22%). Forty-six patients (87%) received flank radiation therapy (RT). Seven children (13%) did not receive flank RT. The median delay between surgery and the initiation of RT was 9 days (range, 3-61). The median RT dose was 10.8 Gy (range, 10-36). The flank RT doses were as follows: 10.5 or 10.8 Gy in 25 patients (47%), 11-19.9 Gy in 2 patients (4%), 20-29.9 Gy in 9 patients (17%), and 30-40 Gy in 10 patients (19%). The median follow-up for the entire group was 17 years (range, 2-36). The relapse-free and cancer-specific survival rate was 100% at the last follow-up examination. Conclusions: The present results have demonstrated that children with revised stage I CCSK using the NWTS-5 staging criteria have excellent survival rates despite the use of varying RT doses and chemotherapy regimens in the NWTS 1-5 protocols.

  10. Validation of a Score Predicting Post-Treatment Ambulatory Status After Radiotherapy for Metastatic Spinal Cord Compression

    SciTech Connect (OSTI)

    Rades, Dirk, E-mail: Rades.Dirk@gmx.ne [Department of Radiation Oncology, University Hospital Schleswig-Holstein, Lubeck (Germany); Douglas, Sarah; Huttenlocher, Stefan [Department of Radiation Oncology, University Hospital Schleswig-Holstein, Lubeck (Germany); Rudat, Volker [Department of Radiation Oncology, Saad Specialist Hospital, Al Khobar (Saudi Arabia); Department of Radiation Oncology, University Medical Center Hamburg-Eppendorf (Germany); Veninga, Theo [Department of Radiotherapy, Dr. Bernard Verbeeten Institute, Tilburg (Netherlands); Stalpers, Lukas J.A. [Department of Radiotherapy, Academic Medical Center, Amsterdam (Netherlands); Basic, Hiba [Department of Radiation Oncology, University Hospital Sarajevo (Bosnia and Herzegowina); Karstens, Johann H. [Department of Radiation Oncology, Medical School Hannover (Germany); Hoskin, Peter J. [Department of Clinical Oncology, Mount Vernon Cancer Center, Northwood (United Kingdom); Adamietz, Irenaeus A. [Department of Radiation Oncology, Ruhr University Bochum (Germany); Schild, Steven E. [Department of Radiation Oncology, Mayo Clinic, Scottsdale, Arizona (United States)

    2011-04-01T23:59:59.000Z

    Purpose: A score predicting post-radiotherapy (RT) ambulatory status was developed based on 2,096 retrospectively evaluated metastatic spinal cord compression (MSCC) patients. This study aimed to validate the score in a prospective series. Methods and Materials: The score included five factors associated with post-RT ambulatory status: tumor type, interval tumor diagnosis to MSCC, visceral metastases, pre-RT motor function, time developing motor deficits. Patients were divided into five groups: 21-28, 29-31, 32-34, 35-37, 38-44 points. In this study, 653 prospectively followed patients were divided into the same groups. Furthermore, the number of prognostic groups was reduced from five to three (21-28, 29-37, 38-44 points). Post-RT ambulatory rates from this series were compared with the retrospective series. Additionally, this series was compared with 104 patients receiving decompressive surgery plus RT (41 laminectomy, 63 laminectomy plus stabilization of vertebrae). Results: In this study, post-RT ambulatory rates were 10.6% (21-28 points), 43.5% (29-31 points), 71.0% (32-34 points), 89.5% (35-37 points), and 98.5% (38-44 points). Ambulatory rates from the retrospective study were 6.2%, 43.5%, 70.0%, 86.1%, and 98.7%. After regrouping, ambulatory rates were 10.6% (21-28 points), 70.9% (29-37 points), and 98.5% (38-44 points) in this series, and 6.2%, 68.4%, and 98.7% in the retrospective series. Ambulatory rates were 0%, 62.5%, and 90.9% in the laminectomy plus RT group, and 14.3%, 83.9%, and 100% in the laminectomy + stabilization plus RT group. Conclusions: Ambulatory rates in the different groups in this study were similar to those in the retrospective study demonstrating the validity of the score. Using only three groups is simplier for clinical routine.

  11. Intern experience at the Texas Transportation Institute: an internship report

    E-Print Network [OSTI]

    Andersen, Donald A.

    2013-03-13T23:59:59.000Z

    -Word Sequential Signs. Trthues osmmtis a gyOIEX ADEC CTfA EUxRT& yOIEX ADEC yOIEX ADEC CTfA EUxRT yaMavav yaMaMav yaMa&a& yaMava& yaMaMa& Ppqs v qFGFqsq 19 Ppqs 8 iFGsm 2js c:h1s" pn srupm:"sm "s(:F"sq 2p u"smsc2 2js sc2F"s hsmmtis) % CO RR EC T RE SP...

  12. On Modified Gravity

    E-Print Network [OSTI]

    Ivan Dimitrijevic; Branko Dragovich; Jelena Grujic; Zoran Rakic

    2012-04-09T23:59:59.000Z

    We consider some aspects of nonlocal modified gravity, where nonlocality is of the type $R \\mathcal{F}(\\Box) R$. In particular, using ansatz of the form $\\Box R = c R^\\gamma,$ we find a few $R(t)$ solutions for the spatially flat FLRW metric. There are singular and nonsingular bounce solutions. For late cosmic time, scalar curvature R(t) is in low regime and scale factor a(t) is decelerated. R (t) = 0 satisfies all equations when k = -1.

  13. Instability localized at the inner surface of an imploding spherical shell

    SciTech Connect (OSTI)

    Han, S.J.

    1983-01-01T23:59:59.000Z

    It is shown that in an imploding spherical shell the surface instabilities are of two different types. The first, which occurs at the outer surfaces, is the Rayleigh-Taylor instability. The second instability occurs at the inner surface. This latter instability is not as disruptive as R-T modes, but it has three basic properties which differ considerably from those of the R-T instability: (1) it is oscillatory at early times; (2) it grows faster in the long wavelength modes; (3) it depends on the equation of state. It is further shown that this new instability is driven by amplified sound waves in the shell.

  14. Disruption of DNA methylation induces genome-specific changes in gene expression in Arabidopsis allotetraploids

    E-Print Network [OSTI]

    Chen, Meng

    2007-04-25T23:59:59.000Z

    methylation occurs in the 5? region of a down-regulated gene At5g25610 in met1 lines???????...??. 22 Figure 2.5 Sequence alignment of centromere satellite repeats originating from A. thaliana and A. arenosa???????????.??........ 23 Figure 2.6...-regulated in allo733, allo738 and met1????????????????? 54 Figure 3.6 RT-PCR and SSCP for At5g25610 which is up-regulated in allo733 and allo738, but down-regulated in met1?? 55 Figure 3.7 RT-PCR and SSCP for the genes that are down...

  15. Early lineage restriction and regional segregation during mammalian heart development

    E-Print Network [OSTI]

    Lescroart, Fabienne; Chabab, Samira; Lin, Xionghui; Rulands, Steffen; Paulissen, Catherine; Rodolosse, Annie; Auer, Herbert; Achouri, Younes; Dubois, Christine; Bondue, Antoine; Simons, Benjamin D.; Blanpain, Cdric

    2014-08-24T23:59:59.000Z

    into the different cardiovascular lineages using single cell marking in vivo. Results Dox inducible Mesp1 reporter and CRE mediated recombination To assess the contribution of single Mesp1 expressing progenitors at different time points during embryonic... embryonic development and ESC differentiation 6, 16 (Fig. 1). We identified 6 Mesp1-rtTA founders that produce embryos with faithful expression of the tdTomato in the heart when Dox was administrated to Mesp1-rtTA/tetO-Cre/Rosa-dtTomato embryos between E6...

  16. Treatment and Outcomes in Patients With Primary Cutaneous B-Cell Lymphoma: The BC Cancer Agency Experience

    SciTech Connect (OSTI)

    Hamilton, Sarah N., E-mail: shamilton7@bccancer.bc.ca [University of British Columbia, Vancouver (Canada); Radiation Therapy Program, BC Cancer Agency, Vancouver (Canada); Wai, Elaine S. [Radiation Therapy Program, BC Cancer Agency, Victoria (Canada); Tan, King [Department of Pathology, BC Cancer Agency, Vancouver (Canada); Alexander, Cheryl [Radiation Therapy Program, BC Cancer Agency, Victoria (Canada); Gascoyne, Randy D. [University of British Columbia, Vancouver (Canada); Department of Pathology, BC Cancer Agency, Vancouver (Canada); Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver (Canada); Connors, Joseph M. [University of British Columbia, Vancouver (Canada); Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver (Canada)

    2013-11-15T23:59:59.000Z

    Purpose: To review the treatment and outcomes of patients with primary cutaneous B-cell lymphoma (CBCL). Methods and Materials: Clinical characteristics, treatment, and outcomes were analyzed for all patients referred to our institution from 1981 through 2011 with primary CBCL without extracutaneous or distant nodal spread at diagnosis (n=136). Hematopathologists classified 99% of cases using the World Health Organization-European Organization for Research and Treatment of Cancer (WHO-EORTC) guidelines. Results: Median age at diagnosis was 62 years. Classification was 18% diffuse large B-cell leg-type (DLBCL-leg), 32% follicle center (FCCL), 45% marginal zone (MZL), and 6% nonclassifiable (OTHER). Of the 111 subjects with indolent lymphoma (FCCL, MZL, OTHER), 79% received radiation alone (RT), 11% surgery alone, 3% chemotherapy alone, 4% chemotherapy followed by RT, and 3% observation. Following treatment, 29% of subjects relapsed. In-field recurrence occurred in 2% treated with RT and in 33% treated with surgery alone. Of the 25 subjects with DLBCL-leg, 52% received chemotherapy followed by RT, 24% chemotherapy, 20% RT, and 4% surgery alone. Seventy-nine percent received CHOP-type chemotherapy (cyclophosphamide, doxorubicin or epirubicin, vincristine, prednisone), 47% with rituximab added. Overall and disease-specific survival and time to progression at 5 years were 81%, 92%, and 69% for indolent and 26%, 61%, and 54% for DLBCL-leg, respectively. On Cox regression analysis of indolent subjects, RT was associated with better time to progression (P=.05). RT dose, chemo, age >60 y, and >1 lesion were not significantly associated with time to progression. For DLBCL-leg, disease-specific survival at 5 years was 100% for those receiving rituximab versus 67% for no rituximab (P=.13). Conclusions: This review demonstrates better outcomes for indolent histology compared with DLBCL-leg, validating the prognostic utility of the WHO-EORTC classification. In the indolent group, RT was associated with 98% local control. DLBCL-leg is a more aggressive disease; the excellent results in the rituximab group suggest it has an important role in management.

  17. Nonlinear adaptive control using radial basis function approximants

    E-Print Network [OSTI]

    Petersen, Jerry Lee

    1993-01-01T23:59:59.000Z

    for answering my constant barrage of questions, as well as Ayman Farahat and Bryan Milligan for their knowledge of mathematics and computer systems, respectively. Finally, I am eternally grateful to my parents for teaching the value of a good education... Response for rt = 54 Figure 9: Tracking Control Response for q = 54. 2 Figure 10: Tracking Control Response for rt = 54. 4 Figure 11: Tracking Control Response for q = 56 29 30 30 31 Figure 12: Trajectory History and Constant Center Grid 1 Figure...

  18. Unified Modeling of Complex Real-Time Control Systems

    E-Print Network [OSTI]

    Hai, He; Chi-Lan, Cai

    2011-01-01T23:59:59.000Z

    Complex real-time control system is a software dense and algorithms dense system, which needs modern software engineering techniques to design. UML is an object-oriented industrial standard modeling language, used more and more in real-time domain. This paper first analyses the advantages and problems of using UML for real-time control systems design. Then, it proposes an extension of UML-RT to support time-continuous subsystems modeling. So we can unify modeling of complex real-time control systems on UML-RT platform, from requirement analysis, model design, simulation, until generation code.

  19. Proton Radiotherapy for High-Risk Pediatric Neuroblastoma: Early Outcomes and Dose Comparison

    SciTech Connect (OSTI)

    Hattangadi, Jona A. [Harvard Radiation Oncology Program, Boston, MA (United States); Rombi, Barbara [Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States); Provincial Agency for Proton Therapy, Trento (Italy); Yock, Torunn I.; Broussard, George [Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States); Friedmann, Alison M.; Huang, Mary [Department of Pediatric Hematology-Oncology, Massachusetts General Hospital, Boston, MA (United States); Chen, Yen-Lin E.; Lu, Hsiao-Ming; Kooy, Hanne [Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States); MacDonald, Shannon M., E-mail: smacdonald@partners.org [Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States)

    2012-07-01T23:59:59.000Z

    Purpose: To report the early outcomes for children with high-risk neuroblastoma treated with proton radiotherapy (RT) and to compare the dose distributions for intensity-modulated photon RT (IMRT), three-dimensional conformal proton RT (3D-CPT), and intensity-modulated proton RT to the postoperative tumor bed. Methods and Materials: All patients with high-risk (International Neuroblastoma Staging System Stage III or IV) neuroblastoma treated between 2005 and 2010 at our institution were included. All patients received induction chemotherapy, surgical resection of residual disease, high-dose chemotherapy with stem cell rescue, and adjuvant 3D-CPT to the primary tumor sites. The patients were followed with clinical examinations, imaging, and laboratory testing every 6 months to monitor disease control and side effects. IMRT, 3D-CPT, and intensity-modulated proton RT plans were generated and compared for a representative case of adjuvant RT to the primary tumor bed followed by a boost. Results: Nine patients were treated with 3D-CPT. The median age at diagnosis was 2 years (range 10 months to 4 years), and all patients had Stage IV disease. All patients had unfavorable histologic characteristics (poorly differentiated histologic features in 8, N-Myc amplification in 6, and 1p/11q chromosomal abnormalities in 4). The median tumor size at diagnosis was 11.4 cm (range 7-16) in maximal dimension. At a median follow-up of 38 months (range 11-70), there were no local failures. Four patients developed distant failure, and, of these, two died of disease. Acute side effects included Grade 1 skin erythema in 5 patients and Grade 2 anorexia in 2 patients. Although comparable target coverage was achieved with all three modalities, proton therapy achieved substantial normal tissue sparing compared with IMRT. Intensity-modulated proton RT allowed additional sparing of the kidneys, lungs, and heart. Conclusions: Preliminary outcomes reveal excellent local control with proton therapy for high-risk neuroblastoma, although distant failures continu to occur. Dosimetric comparisons demonstrate the advantage of proton RT compared with IMRT in this setting, allowing more conformal treatment and better normal tissue sparing.

  20. Disruption of DNA methylation induces genome-specific changes in gene expression in Arabidopsis allotetraploids

    E-Print Network [OSTI]

    Chen, Meng

    2007-04-25T23:59:59.000Z

    methylation occurs in the 5? region of a down-regulated gene At5g25610 in met1 lines???????...??. 22 Figure 2.5 Sequence alignment of centromere satellite repeats originating from A. thaliana and A. arenosa???????????.??........ 23 Figure 2.6...-regulated in allo733, allo738 and met1????????????????? 54 Figure 3.6 RT-PCR and SSCP for At5g25610 which is up-regulated in allo733 and allo738, but down-regulated in met1?? 55 Figure 3.7 RT-PCR and SSCP for the genes that are down...

  1. Modified Hamiltonian formalism for Regge Teitelboim Cosmology

    E-Print Network [OSTI]

    Pinaki Patra; Md. Raju; Gargi Manna; Jyoti Prasad Saha

    2014-12-10T23:59:59.000Z

    The Ostrogradski approach for the Hamiltonian formalism of higher derivative theory is not satisfactory because of the reason that the Lagrangian cannot be viewed as a function on the tangent bundle to coordinate manifold. In this article, we have used an alternative approach which leads directly to the Lagrangian which, being a function on the tangent manifold, gives correct equation of motion; no new coordinate variables need to be added. This approach can be directly used to the singular (in Ostrogradski sense) Lagrangian. We have used this method for the Regge Teitelboim (RT) minisuperspace cosmological model. We have obtained the Hamiltonian of the dynamical equation of the scale factor of RT model.

  2. Modification of solid state CdZnTe (CZT) radiation detectors with high sensitivity or high resolution operation

    DOE Patents [OSTI]

    Washington, II, Aaron L; Duff, Martine C; Teague, Lucile C; Burger, Arnold; Groza, Michael

    2014-11-11T23:59:59.000Z

    An apparatus and process is provided to illustrate the manipulation of the internal electric field of CZT using multiple wavelength light illumination on the crystal surface at RT. The control of the internal electric field is shown through the polarization in the IR transmission image under illumination as a result of the Pockels effect.

  3. AER1301: KINETIC THEORY OF GASES Assignment #1

    E-Print Network [OSTI]

    Groth, Clinton P. T.

    AER1301: KINETIC THEORY OF GASES Assignment #1 1. A hypersonic wind tunnel is contructed so such that the mean free path, , is given by the expression = 16 5 1 2RT , where R is the ideal gas constant and p space and the length of each side of the cube is 4v. (a) Obtain an expression for the normalized

  4. Cornell University, Office of Sponsored Programs Awards Received in June 2010

    E-Print Network [OSTI]

    Danforth, Bryan Nicholas

    NEMATODE INFECTION $76,230 TJC 56009 AQUADRO, CHARLES F CLARK, NATHANIEL L MOLECULAR BIO-E DHHS (NIH) MOLECULAR EVOLUTION IN THE CONTEXT OF PROTEIN STRUCTURE AND STABILITY: NATHANIEL CLARK, FELLOW $52,154 RT,206 AJP 56905 CHRISTOPHERSON, SUSAN M DONAGHY, KIERAN PATRICK CRP HEINZ ENDOW A COMPREHENSIVE ECONOMIC

  5. Det sovjetiske kernevbenprogram i perioden 1949-1956 gav massiv strlingsudsttelse af arbejdere og befolkning

    E-Print Network [OSTI]

    . Den første produktionsenhed blev opført i Chelyabinsk regionen omkring 15 km fra byen Kysthym i det, eksempelvis Chelyabinsk-40 eller Tomsk-7. I løbet af de første ti års drift af Mayak-enheden blev store

  6. technology offer Vienna University of Technology | Research and Transfer Support | Claudia Doubek

    E-Print Network [OSTI]

    Szmolyan, Peter

    with internal heat exchangers, two bunkers (hot and cold) and equipment for handling the storage material sand) Industrial Heat recovery ("Ash Cooler" after a fluidized bed combustion chamber) Development Status A cold.doubek@tuwien.ac.at | http://www.rt.tuwien.ac.at SandTES - High Temperature Sand Thermal Energy Storage Thermal Energy

  7. Utrecht Multi-Person Motion (UMPM) N.P. van der Aa, X. Luo, G.-J. Giezeman

    E-Print Network [OSTI]

    Utrecht, Universiteit

    Utrecht Multi-Person Motion (UMPM) benchmark N.P. van der Aa, X. Luo, G.-J. Giezeman R.T. Tan, R Utrecht University, Utrecht, The Netherlands www.cs.uu.nl #12;ISSN: 0924-3275 Department of Information and Computing Sciences Utrecht University P.O. Box 80.089 3508 TB Utrecht The Netherlands #12;Abstract Analyzing

  8. Dual Luciferase Assay Lucho Fuentealba 2008

    E-Print Network [OSTI]

    De Robertis, Eddy M.

    -Luciferase Assay System from Promega (Cat# E1960) - Dilute the Passive Lysis Buffer (PLB) Harvesting of cells in each well (for a 12-well plate) - Rock the plate for 15 min at RT - Take the extract and place in microfuge tubes. Keep at -20C until use - Thaw on water the Luciferase Assay Buffer II (green label

  9. Feature Reinforcement Learning In Practice September 9, 2011

    E-Print Network [OSTI]

    Hutter, Marcus

    Feature Reinforcement Learning In Practice #12;Problems Robotic control in an unknown environment Feature #12;Problem formulation ht = a1o1r1o2r2a2 . . . otrt at = Agent(ht) ot+1rt+1 = Environment (Closed Finite State Machines) Markov trees are trees where given st and at, ot+1, we know st+1 Parallel

  10. 698 BioScience October 2010 / Vol. 60 No. 9 www.biosciencemag.org Opportunities and Constraints for

    E-Print Network [OSTI]

    Jackson, Robert B.

    , but maximizing productivity and biomass could make maintaining water supply, biodiversity, and other ecosystem and Constraints for Forest Climate Mitigation RobeRt b. Jackson and Justin s. bakeR Reversing forest losses, we examine some ecological, demographic, and economic opportunities and constraints on forest

  11. Covalently Linked Plasticizers: Triazole Analogues of Phthalate Plasticizers Prepared by Mild Copper-Free ??Click? Reactions with Azide-Functionalized PVC

    E-Print Network [OSTI]

    Earla, Aruna; Braslau, Rebecca

    2014-01-01T23:59:59.000Z

    with Azide-functionalized PVC 1 Aruna Earla and RebeccaE-mail: rbraslau@ucsc.edu Tel: (831) 459-3087 PVC N 3 RO 2C CO 2 R PVC N 3 RT, 27 h Cl copper-free N N "click" N Cl CO

  12. An Experimental and Theoretical Multi-Mbar Study of Ti-6Al-4V

    SciTech Connect (OSTI)

    Tegner, B E; Macleod, S G; CYNN, H; Proctor, J; Evans, W J; McMahon, M I; Ackland, G J

    2011-04-13T23:59:59.000Z

    We report results from an experimental and theoretical study of the room temperature (RT) compression of the ternary alloy Ti-6Al-4V. In this work, we have extended knowledge of the equation of state (EOS) from 40 GPa to 221 GPa, and observed a different sequence of phase transitions to that reported previously for pure Ti.

  13. technology offer Research and Transfer Support | DI Karin Hofmann

    E-Print Network [OSTI]

    Szmolyan, Peter

    is the usage of a cyclone collector in the form of an axial hydro cyclone to separate the unwanted sediment://www.rt.tuwien.ac.at Sediment Removal by an Axial Hydro Cyclone key words: desilting | axial cyclone | pressure pipe| hydropower by implementing an axial hydro cyclone. This device produces a heavy swirling flow, the particles are carried

  14. Transverse Feedback in a 100 TeV Storage Ring

    E-Print Network [OSTI]

    Lambertson, G.

    2011-01-01T23:59:59.000Z

    Proceedings Transverse Feedback in a 100 TeV Storage Ring G.DE93 001571 TRANSVERSE FEEDBACK IN A 100 TeV STORAGE RING*IS UNLIMITED r-t_9. TRANSVERSE FEEDBACK IN A 100 TeV STORAGE

  15. Interactive Decision-Support Tool for Risk-Based Radiation Therapy Plan Comparison for Hodgkin Lymphoma

    SciTech Connect (OSTI)

    Brodin, N. Patrik [Department of Radiation Oncology, Albert Einstein College of Medicine of Yeshiva University, New York, New York (United States); Maraldo, Maja V., E-mail: dra.maraldo@gmail.com [Department of Radiation Oncology, Faculty of Sciences, University of Copenhagen, Copenhagen (Denmark); Aznar, Marianne C. [Department of Radiation Oncology, Faculty of Sciences, University of Copenhagen, Copenhagen (Denmark); Niels Bohr Institute, Faculty of Sciences, University of Copenhagen, Copenhagen (Denmark); Vogelius, Ivan R. [Department of Radiation Oncology, Faculty of Sciences, University of Copenhagen, Copenhagen (Denmark); Petersen, Peter M. [Department of Radiation Oncology, Faculty of Sciences, University of Copenhagen, Copenhagen (Denmark); Department of Oncology, Faculty of Sciences, University of Copenhagen, Copenhagen (Denmark); Department of Hematology, Rigshospitalet, Faculty of Sciences, University of Copenhagen, Copenhagen (Denmark); Bentzen, Sren M. [Department of Radiation Oncology, Faculty of Sciences, University of Copenhagen, Copenhagen (Denmark); Department of Human Oncology, University of Wisconsin Medical School, Madison, Wisconsin (United States); Specht, Lena [Department of Radiation Oncology, Faculty of Sciences, University of Copenhagen, Copenhagen (Denmark); Department of Oncology, Faculty of Sciences, University of Copenhagen, Copenhagen (Denmark); Department of Hematology, Rigshospitalet, Faculty of Sciences, University of Copenhagen, Copenhagen (Denmark)

    2014-02-01T23:59:59.000Z

    Purpose: To present a novel tool that allows quantitative estimation and visualization of the risk of various relevant normal tissue endpoints to aid in treatment plan comparison and clinical decision making in radiation therapy (RT) planning for Hodgkin lymphoma (HL). Methods and Materials: A decision-support tool for risk-based, individualized treatment plan comparison is presented. The tool displays doseresponse relationships, derived from published clinical data, for a number of relevant side effects and thereby provides direct visualization of the trade-off between these endpoints. The Quantitative Analyses of Normal Tissue Effects in the Clinic reports were applied, complemented with newer data where available. A relevance score was assigned to each data source, reflecting how relevant the input data are to current RT for HL. Results: The tool is applied to visualize the local steepness of doseresponse curves to drive the reoptimization of a volumetric modulated arc therapy treatment plan for an HL patient with head-and-neck involvement. We also use this decision-support tool to visualize and quantitatively evaluate the trade-off between a 3-dimensional conformal RT plan and a volumetric modulated arc therapy plan for a patient with mediastinal HL. Conclusion: This multiple-endpoint decision-support tool provides quantitative risk estimates to supplement the clinical judgment of the radiation oncologist when comparing different RT options.

  16. Shipley Protocol: Last Mofified by Jack: 8/18/2012 5:54:00 PM

    E-Print Network [OSTI]

    Zahn, Jeffrey

    surfaces are dry and clear of chemicals. Coating: 1. Remove chuck from spinner and line the spinner bucket dry the substrate until it is dry. 5. Dehydrate Substrates a. Place the substrate in the oven at ~200°C for 30 minutes, then cool to RT shortly before spin-coating. *Make sure to turn on oven before

  17. Below is a list of hotels, inns and beds and breakfasts in and around Ithaca we've compiled for your information. All prices are before applicable taxes. Although we believe prices and discount

    E-Print Network [OSTI]

    Richardson Jr., James E.

    @houndandhare.com $150 (The grandfather of the innkeeper, Zetta Sprole, a fourth generation Cornellian, helped build://www.clarionhotelithaca.com $99.95 - $109.95 Grayhaven Motel 657 Elmira Rd NYS Rt. 13 S. Ithaca, NY 14850 607-272-6434 877

  18. ISSN0249-6399ISRNINRIA/RR--8030--FR+ENG Project-Team S4

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    time part of block-diagrams formalisms such as Simulink, Modelica, or Scade. Code is modular-ensemble discret des formalismes de diagrammes de bloc tels que Simulink, Modelica ou Scade. Un code est modulaire for embedded control systems, such as Simulink/Stateflow, Modelica, Scade, RT-Builder, and Ptolemy II, have

  19. AnnualReport Franz Graf

    E-Print Network [OSTI]

    Middeldorp, Aart

    2011 AnnualReport #12;Franz Graf Cover design adapted from "76543210" Graphite and India ink with symbolic representations of CoSMIC DIMEnSIonS. [...] And yet the sequences of lines are laced Schmidt (excerpts) Ornament, symbol, reversed writing, shadow lines #12;#12;AnnuAl RepoRt 2011 Annual

  20. photo:martindee Toothless no more

    E-Print Network [OSTI]

    Farrell, Anthony P.

    amos RembRandt's aRt was a science, study finds A new study by UBC researcher Steve DiPaola suggests that the Dutch painter Rembrandt pioneered scientific techniques that guide the viewer's gaze around a painting, making them linger longer. DiPaola explains that Rembrandt captured the viewer's attention by placing

  1. Abstract--In this work, we first introduced a reorganized form of the Novikov's inversion formula for the attenuated Radon

    E-Print Network [OSTI]

    Abstract--In this work, we first introduced a reorganized form of the Novikov's inversion formula) applying the reorganized Novikov's formula. Numerical evaluations demonstrated its computational efficiency the attenuated Radon transform (AtRT). A closed- form inversion formula for parallel-beam (PB) geometry

  2. Start Date: Hours per Week

    E-Print Network [OSTI]

    Garfunkel, Eric

    Wednesday Thursday Friday Saturday Sunday Storming Robots Technology Learning Institution 3322 Rt. 22 West, Suite 402 Branchburg NJ 08876 Elizabeth Mabrey emabrey@stormingrobots.com 908-595-1010 Robotics Instructor / Assistant $15 to $30 Any Time from 2 to 12 hours per week one 1) Instructor/Assistant

  3. 2007 SCE Business Briefing Challenges Integrating Electric

    E-Print Network [OSTI]

    Scott, Christopher

    Southern California Edison #12;2 2007 SCE Business Briefing Outline Context: Energy Needs vs. Water;16 2007 SCE Business Briefing Hauling and Disposal Estimates Disposal Facility Mileage R/T Costs2007 SCE Business Briefing Challenges Integrating Electric Generation and Potable Aquifer Usage

  4. Reduction of DNA contamination in RNA samples for reverse transcription-polymerase chain reaction using selective precipitation by compaction agents.

    E-Print Network [OSTI]

    Fox, George

    Reduction of DNA contamination in RNA samples for reverse transcription-polymerase chain reaction by reverse transcription-polymerase chain reaction (RT-PCR) is DNA contamination, which can produce artifactually increased mRNA concentration. Current methods to eliminate contaminating DNA can compromise

  5. in2p3-00356643,version1-28Jan2009 Author manuscript, published in "XXIV Linear Accelerator Conference "LINAC'08", Victoria : Canada (2008)"

    E-Print Network [OSTI]

    Boyer, Edmond

    2008-01-01T23:59:59.000Z

    Conference "LINAC'08", Victoria : Canada (2008)" #12;LAL/RT 08-22 October 2008 BEAM DYNAMICS SIMULATIONS dynamic simulations using the PARMELA code to study the performances of the alphaX photo, the surface electrical field is reduced by a factor 2 with respect to the more usual cylindrical shape. So one

  6. An Analysis of a Spreader Bar Crane Mounted Gamma-Ray Radiation Detection System

    E-Print Network [OSTI]

    Grypp, Matthew D

    2013-04-08T23:59:59.000Z

    photoelectric effect PMT photomultiplier tube PNNL Pacific Northwest National Laboratory viii PoT Port of Tacoma PVT poly-vinyl toluene R resolution RT real time RPM radiation portal monitor s second SBC spreader.... LITERATURE REVIEW ......................................................................................... 9 3.1 Radiation Portal Monitors ............................................................................ 9 3.2 General Areas...

  7. Physics 214 Notes on Cherenkov radiation Winter 2013 The power spectrum of Cherenkov radiation

    E-Print Network [OSTI]

    California at Santa Cruz, University of

    velocity v, with no accel- eration. In this case, the particle trajectory is given by r(t) = vt. Using · v c + O 1 r2 . (8) If ^n · v = c/nr (which is possible if the charged particle is moving faster than

  8. Nondestructive Evaluation Quality Procedure: Personnel Qualification and Certification Radiographic Testing-Levels I& II

    SciTech Connect (OSTI)

    Dolan, K; Rikard, R D; Rodriquez, J

    2003-07-01T23:59:59.000Z

    This Operational Procedure establishes the minimum requirements for the qualification and certification/recertification of Nondestructive Evaluation (NDE) personnel in the nondestructive testing (NDT) radiographic testing (RT) method. This document is in accordance with the American Society for Nondestructive Testing Recommended Practice SNT-TC-1A, 1996, except as amended herein.

  9. Theoretical Study ofTheoretical Study of ReactionReaction

    E-Print Network [OSTI]

    QQQQQ = 1-Electronic 1 10n n = 3N 5 n = 3N 6 Vibration 102 1033Rotation 3D 10 1022Rotation. The program prints out the reaction rate in the Arrhenius form (k = A Tn exp(-Ea/RT)) over the temperature Energy PathMinimum Energy PathMinimum Energy PathMinimum Energy Path MEPMEPMEPMEP

  10. 44 JULY 2009, GSA TODAY Peter Molnar, Dept. of Geological Sciences, Cooperative

    E-Print Network [OSTI]

    Mojzsis, Stephen J.

    is the perfect gas law: PV = nRT . (1) P is pressure, V is volume, n is the number of moles of a gas, R, then at least one of volume, temperature, and conceivably the number of moles of gas must change. Here it might, and tectonic processes also change, though more slowly. "Most re- gions," because there always is a place where

  11. An improved equation of state for molal volumes of liquid hydrocarbons at high temperatures and pressure

    E-Print Network [OSTI]

    Latimer, James K

    1964-01-01T23:59:59.000Z

    equation for the variation of pressure, volume, and temperature is that of Kammerlingh-Onnes. It is written I5 PV = RT(l +~BT +MCT + ) yz where B(T), C(T), etc. are functions of temperature. The Wohl equation of state, an Intermediate between the van...

  12. Quercetin and Chlorogenic Acid Mitigate DSS-Induced Changes in Expression of Select Pro-Inflammatory Cytokines and Short Chain Fatty Acid Transporter Genes

    E-Print Network [OSTI]

    Piefer, Leigh

    2012-10-19T23:59:59.000Z

    oxide synthase LPS lipopolysaccharide LS least squares MCT-1 monocarboxylate transporter-1 MyD88 myeloid differentiation factor-88 NF-?B nuclear transcription factor kappa B PBS phosphate buffered solution PFA paraformaldehyde RT-PCR reverse... animals (acetic acid, pMCT-1 and SLC5A8 mRNA levels show that DSS significantly...

  13. IAU Symposium 219: Stars as Suns: Activity, Evolution, Planets ASP Conference Series, Vol. XX, 2004

    E-Print Network [OSTI]

    Guedel, Manuel

    model for the instantaneous emission rate (intensity) in a #12;xed energy band: r(t) = X k a k f(t t kIAU Symposium 219: Stars as Suns: Activity, Evolution, Planets ASP Conference Series, Vol. XX, 2004 solvable statistical model which re- lates the amplitude distribution of stellar ares to the observed his

  14. Early Clinical Outcomes Using Proton Radiation for Children With Central Nervous System Atypical Teratoid Rhabdoid Tumors

    SciTech Connect (OSTI)

    De Amorim Bernstein, Karen; Sethi, Roshan; Trofimov, Alexei; Zeng, Chuan [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States)] [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States); Fullerton, Barbara [Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts (United States)] [Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts (United States); Yeap, Beow Y. [Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States)] [Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States); Ebb, David [Department of Pediatric Hematology-Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States)] [Department of Pediatric Hematology-Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States); Tarbell, Nancy J.; Yock, Torunn I. [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States)] [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States); MacDonald, Shannon M., E-mail: smacdonald@partners.org [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (United States)

    2013-05-01T23:59:59.000Z

    Purpose: Atypical teratoid/rhabdoid tumor (AT/RT) is an uncommon and aggressive tumor that often affects infants. Irradiation improves survival but has traditionally been avoided in patients under the age of 3 due to the increasing risk of neurocognitive side effects. We report the first cohort of AT/RT patients treated with proton therapy. Methods and Materials: All patients with AT/RT treated at Massachusetts General Hospital (MGH) Frances H. Burr Proton Beam Therapy Benter between July 2004 and November 2011 were included in this study. All patients were treated with 3-dimensional conformal proton therapy (3D-CPT). Results: Ten consecutive patients of a median 2.3 years of age and with a median follow-up of 27.3 months (range, 11.3-99.4 months) were identified. Two patients suffered distant relapse; 1 patient was successfully treated with involved field irradiation and chemotherapy, while the second patient died of disease. At last follow-up, 9 patients were alive without evidence of disease. Proton radiation demonstrated increasing sparing of the cerebrum, temporal lobe, cochlea, and hypothalamus. Conclusions: Initial clinical outcomes with proton therapy are favorable. The advantages of proton therapy are particularly suited to the treatment of AT/RT, a tumor that often requires irradiation treatment at an age when avoiding irradiation to healthy tissues is most desirable.

  15. SuStainability 02 University of Calgary

    E-Print Network [OSTI]

    Calgary, University of

    SuStainability RepoRt 2012-2013 #12;02 University of Calgary Table of Contents What is Sustainability? The University of Calgary Sustainability Policy defines sustainability as articulated: "Sustainable development is development that meets the needs of the present without compromising the ability

  16. 11-level Cascaded H-bridge Grid-tied Inverter Interface with Solar Panels

    E-Print Network [OSTI]

    Tolbert, Leon M.

    11-level Cascaded H-bridge Grid-tied Inverter Interface with Solar Panels Faete Filho, Yue Cao multilevel DC-AC grid-tied inverter. Each inverter bridge is connected to a 200 W solar panel. OPAL-RT lab match. A novel SPWM scheme is proposed in this paper to be used with the solar panels that can account

  17. Combined Cryo and Room-Temperature Ball Milling to Produce Ultrafine Halide Crystallites

    E-Print Network [OSTI]

    Srivastava, Kumar Vaibhav

    Combined Cryo and Room-Temperature Ball Milling to Produce Ultrafine Halide Crystallites AKASH milling at cryogenic temperature as well as room temperature (RT) has been carried out to prepare out in a high-energy ball mill, and it involves repeated deformation, cold-welding, fractur- ing

  18. Structural response of oxidation resistant carbon-carbon composites

    E-Print Network [OSTI]

    Ashley, Timothy Harold

    1996-01-01T23:59:59.000Z

    subjected to thermo-mechanical loading. The analytical models are compared to test data to verify the predictions of the lamina response. The material system studied is HITCO 2D CC137EH, highly inhibited, eight harness satin weave, RT42 CVD SiC coated carbon...

  19. Benchmarking a Visual-Basic based multi-component one-dimensional reactive transport modeling tool

    E-Print Network [OSTI]

    Clement, Prabhakar

    Benchmarking a Visual-Basic based multi-component one-dimensional reactive transport modeling tool of a comprehensive numerical modeling tool, RT1D, which can be used for simulating biochemical and geochemical, and it does not require any additional software tools. The code can be easily adapted by others for simulating

  20. Oscillatory correlates of proactive interference in a recognition memory task 568.23 Marieke K. van Vugt1

    E-Print Network [OSTI]

    van Vugt, Marieke

    ) Monsell (1978): recent nega- tives paradigm Sternberg recognition memory task well-defined stimulus space chan 14 Task PLS SS Results - within-subject analysis · differences between univariate and multivariate)) Stimulus space structural vs. temporal similarity: - accuracy RT proactive inter- fer- ence (PI) summed

  1. Using the bacteria-2-hybrid system to determine the role of S2 in the equine infectious anemia virus (EIAV) life cycle

    E-Print Network [OSTI]

    Weidner, Jason Lee

    2013-02-22T23:59:59.000Z

    purified (Qiaquick gel extraction kit by Qiagen) so that it could be ligated into some pBT plasmid that had also been cut with BamHI and EcoRI (see fig 5). "M MCS Bptll SBo I Be?H I Gttta I EcaR I Not I PBT Balt Plasmld 3. 2 kb Rt?UVS Rat I...

  2. DYNAMICAL ANALYSIS OF RESONANT TUNNELING IN PRESENCE OF A SELF CONSISTENT POTENTIAL DUE TO THE SPACE CHARGE

    E-Print Network [OSTI]

    Presilla, Carlo

    semiconductor double bar- riers1, in recent years many groups have studied the physics and device application of RT in semiconductor nanostructures2 MBE allows one to control the layer thickness and tune its and demonstrated that the dynamical storage of electrons in the well leads to bistability in the current voltage

  3. The birth of embryonic pluripotency

    E-Print Network [OSTI]

    Boroviak, Thorsten; Nichols, Jennifer

    2014-10-27T23:59:59.000Z

    CA. 1981 The foundation of two distinct cell lineages within the mouse morula. Cell 24, 7180. (doi:10.1016/0092- 8674(81)90502-X)28. Morris SA, Teo RT, Li H, Robson P, Glover DM, Zernicka-Goetz M. 2010 Origin and formation of the first two distinct...

  4. F. S. Bergeret Dpto. de Fsica Terica de la Materia Condensada,

    E-Print Network [OSTI]

    Fominov, Yakov

    ;ORIGINAL MOTIVATION: Experiment on Gd-metallofullerens Kasumov et al. PRB 72 (2005), Orsay tL tRt L R Gd) solution of H 4 Andreev states within the superconducting gap #12; 0' 0 Phase Diagram Vecino et al. PRB & Yafet PRB (1976); SC: Simon& Varma PRB (1999) Trial Wave functions: Singlet: Doublet: #12;All Energies

  5. Abstract PCR recombination describes a process of in vitro chimera formation from non-identical templates.

    E-Print Network [OSTI]

    Wendel, Jonathan F.

    Abstract PCR recombination describes a process of in vitro chimera formation from non") in a common nu- cleus, intergenic chimeras can form during the PCR am- plification of any gene. Here we report transcripts amplified via RT-PCR (Zaphiropoulos 1998). Chimera formation appears to be minimally influenced

  6. ForPeerReview The RAMI On-line Model Checker (ROMC): A web-based benchmarking

    E-Print Network [OSTI]

    Boyer, Edmond

    2801, 31401 Toulouse cedex 9, France e Section for Remote Sensing, Research and Development Department the interactions of solar radiation within a given medium (e.g., clouds, plant canopies) and are used to generate useful for the RT modeling community as a whole, not only by providing a convenient means to evaluate

  7. FY 2015 Computer Hardware and Software Request Form Last Revision 8/12-2013 -JPW

    E-Print Network [OSTI]

    Portman, Douglas

    FY 2015 Computer Hardware and Software Request Form Last Revision 8/12-2013 - JPW End User 5-28217-2610 Cost Estimate Date Group 5-28217-2290 Cost Estimate RT# 5-28217-2120 Cost Estimate CIDS# Non CSG Budget in those sections. >>> No purchases will be made until you contact CSG after the new budgets are approved

  8. About a Conjecture of Guralnick and Thompson

    E-Print Network [OSTI]

    Magaard, Kay

    About a Conjecture of Guralnick and Thompson function in t. Let N be the normal closure of L. Guralnick and Thompson conjecture that apa* *rt from Thompson. Introduction: Let L be a finite genus zero extension of C(t) and let N be its normal clos

  9. JOURNAL DE PHYSIQUE Colloque C8, suppl6ment au no12, Tome 48, dgcembre 1987

    E-Print Network [OSTI]

    Boyer, Edmond

    . An internal friction peak was found at about 180 C in all alloys. The peak height decreased and the modulus increased during subsequent measuring or after an annealing a b o ~ ethe peak temperature. At the same time-................................ ed into oil (130 C, 1 0 0 ~ ~ )or water- (RT, 100C) and were aged for different times (600-3600 s

  10. JOURNAL OF MATHEMATICAL PSYCHOLOGY 21, 93-123 (1980) Decomposing the Reaction Time Distribution

    E-Print Network [OSTI]

    Townsend, James T.

    1980-01-01T23:59:59.000Z

    for reprints should be sent to F. Gregory Ashby, Ohio State University, Human Per- formance Center, 404B West 17th Avenue, Columbus, Ohio 43210. 93 0022-2496/80/020093-31$02.00/O Copyright 0 1980by, it is usually postulated that if two experimental factors affect mean RT in an additive manner, then two

  11. Vol.17 (20125 Application Examples of Structural Health Monitoring

    E-Print Network [OSTI]

    Giurgiutiu, Victor

    Fig. 7 PWAS Impedance Spectrum Variation with Temperature (measured at RT after exposure(PWAS) was presented. The basic principles of applying PWAS to in-situ SHM using in-plane propagation waves are first reviewed. Next, experiments were conducted to verify the thickness measurement ability of PWAS sensor

  12. Use of vegetation for abatement of road traffic noise in a 1:10 scale street model

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    were selected by measuring absorption coefficients and ground impedances in a 1:10 and a full scale was described in in-situ RT measurements with a tree. 2 Urban scale model configurations and measurements 2, France 3305 #12;Sound propagation over the building elements has been evaluated to measure the traffic

  13. Correlation of the electrical resistivity of fluid-saturated cores with water saturation and shaliness

    E-Print Network [OSTI]

    Desai, Bhupendra Chhotabhai

    1966-01-01T23:59:59.000Z

    solids and interstitial water as a slurry of conductive particles in an electrolyte and arrived at the relation- ship 2 (Rf' 'V'w S RfR Rt - (N+Rf) (N+R )R L' f w 'ts f osj 0 R N ts where: Rf = the bulk resistivity of the conductive solids in ohm...

  14. FEASIBILITY OF IN-SITU COMBUSTION OF TAR FROM A TARMAT Sidqi A. Abu-Khamsin

    E-Print Network [OSTI]

    Abu-Khamsin, Sidqi

    ), PO is partial pressure of oxygen (Pa), Cf is fuel concentration (g per cm3 of rock), m is reactionHTO = A exp[-EHTO /(RT)] (2) Where A is a frequency factor (consistent units) and R is the universal gas at the rate needed to generate enough heat to maintain such temperature. Achieving this thermal

  15. MINUTES OF UNIVERSITY COURT 25 June 2013

    E-Print Network [OSTI]

    Mottram, Nigel

    , Scottish and other political representatives, including: the Rt Hon. David Willetts MP UK National Salmond MSP Power Network Demonstration Centre, Energy Advisory Board; Graeme Pearson MSP economic with research leaders from across the University International engagements China, Singapore, Dubai, New York

  16. Vegetation dynamics of a native haymeadow, a grazed meadow, and an oldfield within the San Antonio Prairie of Texas

    E-Print Network [OSTI]

    Hightower, Terry Paul

    1987-01-01T23:59:59.000Z

    Be ardii var. Be ardii, Bo t ious c~rti e d I var. c~rt( du(a, a d Carex icrundunt . Species of lua y soils lncl ded P~as alum plicatulum, Co lo his ~ilndrica, d P~I brist lis p b la . 8 berula. Launchbaugh (1955) studied succession on the San Antonio...

  17. THE SECURITY-CONSTRAINED COMMITMENT AND DISPATCH FOR MIDWEST ISO DAY-AHEAD CO-OPTIMIZED ENERGY AND ANCILLARY SERVICE MARKET

    E-Print Network [OSTI]

    McCalley, James D.

    curves are introduced to allow for efficient pricing of energy and AS capacities by location. Efficient and a market for Financial Transmission Rights (FTRs). The energy markets produce DA and RT locational marginal prices (LMPs) that can vary across the region to reflect local generation production marginal costs

  18. MIDWEST ISO CO-OPTIMIZATION BASED REAL-TIME DISPATCH AND PRICING OF ENERGY AND ANCILLARY SERVICES

    E-Print Network [OSTI]

    Tesfatsion, Leigh

    day-ahead counterpart, real-time locational marginal prices (LMP) are calculated every fiveMIDWEST ISO CO-OPTIMIZATION BASED REAL-TIME DISPATCH AND PRICING OF ENERGY AND ANCILLARY SERVICES-time dispatch and pricing. The RT SCED formulation at the core of the real-time dispatch and pricing market

  19. Never Let Me Down

    E-Print Network [OSTI]

    Shoshanna

    1992-01-01T23:59:59.000Z

    little. "Would you believe it? Shot the RT out of my hand. One in a million." And he flexed his fingers, wincing. Two knuckles were red and swollen, where they had been twisted by the impact "Need a doctor?" "Nah. Ice'll do it" Jax and Murphy were...

  20. The effectiveness of some commercial acaricides for control of certain mites of the Tetranychus telarius complex attacking cotton

    E-Print Network [OSTI]

    Fernandez, Alberto Thomas

    1959-01-01T23:59:59.000Z

    * rt B e (~et n hus t x z o hcG ', ") 1 "t 1 p *'. * of th- ~Petr n thus tel"rius complex as evolved by Dillon (lc!56). Thc members o ". th= . complex, r Darted in Texas, include t!. e I. reen color form, I'. bimaculatus f!arveyp n . two carmine...

  1. BULLETIN OF THE UNITED qTATES FISH COM311SSION. 221 2Bs-THE AMERICIAN BLACIIK BASE.`

    E-Print Network [OSTI]

    BULLETIN OF THE UNITED qTATES FISH COM311SSION. 221 2Bs-THE AMERICIAN BLACIIK BASE.` B y MAX VON and English pub- , lications, it appeared thRt the fish which in North America is known by the name of "black bass" possesses qualities which made it in the highest degree desirable for me to obtain some of theso

  2. Genealogy of Nonperturbative Quantum-Invariants of 3-Manifolds: The Surgical Family

    E-Print Network [OSTI]

    Thomas Kerler

    1996-03-22T23:59:59.000Z

    We study the relations between the invariants $\\tau_{RT}$, $\\tau_{HKR}$, and $\\tau_L$ of Reshetikhin-Turaev, Hennings-Kauffman-Radford, and Lyubashenko, respectively. In particular, we discuss explicitly how $\\tau_L$ specializes to $\\tau_{RT}$ for semisimple categories and to $\\tau_{HKR}$ for Tannakian categories. We give arguments for that $\\tau_L$ is the most general invariant that stems from an extended TQFT. We introduce a canonical, central element, {\\sf Q}, for a quasi-triangular Hopf algebra, $\\A$, that allows us to apply the Hennings algorithm directly, in order to compute $\\tau_{RT}$, which is originally obtained from the semisimple trace-subquotient of $\\A-mod$. Moreover, we generalize Hennings' rules to the context of cobordisms, in order to obtain a TQFT for connected surfaces compatible with $\\tau_{HKR}\\,$. As an application we show that, for lens spaces and $\\A=U_q(sl_2)\\,$, the ratio of $\\tau_{HKR}$ and $\\tau_{RT}$ is the order of the first homology group. In the course of this paper we also outline the topology and the algebra that enter invariance proofs, which contain no reference to 2-handle slides, but to other moves that are local. Finally, we give a list of open questions regarding cellular invariants, as defined by Turaev-Viro, Kuperberg, and others, their relations among each other, and their relations to the surgical invariants from above.

  3. ENERGY I ORNL/Sub/79-2471 1/1 O N= ~ Highly Efficient Commercial

    E-Print Network [OSTI]

    Oak Ridge National Laboratory

    -Combustion Gas-Fired S Water Heater JE i Research and Development R(T^|~ sReport E.A. Lawton L. Irwin ~-i. A PULSE-COMBUSTION GAS-FIRED WATER HEATER RESEARCH AND DEVELOPMENT REPORT L. N. Bohanan E. A. Lawton L of a gas-fired, pulse-combustion water heater for commercial applications has been developed. The prototype

  4. Edward Noble Kramer was born April 17, 1908 in Cambridge, Wisconsin

    E-Print Network [OSTI]

    Wisconsin at Madison, University of

    of the disciplines of chemistry, chemical engineering and materials science and engineering without regard. DE PA RT M E N T O F Materials Science & Engineering College of Engineering University of Wisconsin of Engineering and Applied Sciences Harvard University The Edward Noble Kramer Lectureship Tuesday, September 10

  5. Applied Data Mining for Business Intelligence

    E-Print Network [OSTI]

    capacity grows with twice the speed of processor power. This unbalanced growth relationship will over time validity criteria. #12;Resum´e Business Intelligence (BI) løsninger har igennem mange °ar været et populært

  6. LS- W. Chou

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    S PS i I i 1 10 :: .fu,,.:: if LA."" )-t'll:' :;. . rt1.J:: 'I, 441 B0S5.0HO.3il -'i i i i i i J i .:1 -I . .- . .. : " I j I. Il"" LJ' ;): i -....

  7. Fusion in a Staged Z-pinch

    E-Print Network [OSTI]

    Rahman, H. U.; Ney, P.; Rostoker, N.; Wessel, F. J.

    2009-01-01T23:59:59.000Z

    York (1978) Teller, E. : Fusion. Academic Press, New York (O R I G I N A L A RT I C L E Fusion in a Staged Z-pinch H.U.implosion the sim- ulated fusion-energy yield is 7.6 MJ,

  8. Online Adaptive Replanning Method for Prostate Radiotherapy

    SciTech Connect (OSTI)

    Ahunbay, Ergun E., E-mail: eahunbay@mcw.ed [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States); Peng Cheng; Holmes, Shannon; Godley, Andrew; Lawton, Colleen; Li, X. Allen [Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI (United States)

    2010-08-01T23:59:59.000Z

    Purpose: To report the application of an adaptive replanning technique for prostate cancer radiotherapy (RT), consisting of two steps: (1) segment aperture morphing (SAM), and (2) segment weight optimization (SWO), to account for interfraction variations. Methods and Materials: The new 'SAM+SWO' scheme was retroactively applied to the daily CT images acquired for 10 prostate cancer patients on a linear accelerator and CT-on-Rails combination during the course of RT. Doses generated by the SAM+SWO scheme based on the daily CT images were compared with doses generated after patient repositioning using the current planning target volume (PTV) margin (5 mm, 3 mm toward rectum) and a reduced margin (2 mm), along with full reoptimization scans based on the daily CT images to evaluate dosimetry benefits. Results: For all cases studied, the online replanning method provided significantly better target coverage when compared with repositioning with reduced PTV (13% increase in minimum prostate dose) and improved organ sparing when compared with repositioning with regular PTV (13% decrease in the generalized equivalent uniform dose of rectum). The time required to complete the online replanning process was 6 {+-} 2 minutes. Conclusion: The proposed online replanning method can be used to account for interfraction variations for prostate RT with a practically acceptable time frame (5-10 min) and with significant dosimetric benefits. On the basis of this study, the developed online replanning scheme is being implemented in the clinic for prostate RT.

  9. "A New Rapid Tooling Technique and Its Special Binder Study," Jack Zhou and Z. He, Journal of Rapid Prototyping, Vol. 5, No. 2, pp. 82-88, 1999.

    E-Print Network [OSTI]

    Zhou, Jack

    by the various RP systems can not be applied to real production. Rapid Tooling (RT) technology is defined and efficiently so the resultant part will be representative of production material (Jacobs, 1996). Up to now be considered. Silicone Rubber Technique and Keltool In this kind of techniques (Flint and Ellis, 1994

  10. Ace ble Parts t This report contains a list of electronic common parts which

    E-Print Network [OSTI]

    Rathbun, Julie A.

    for application in ALSEP equipment. The principle factors in listing these parts is the reliability Application and Reliability Bulletin" Vols. I & II. Prepared by j)ftJ/d(~} k/-- P. Sondee.1 HO. ALSEP Parts & Mat'ls Group Supervisor Approved by '-1 ~~ :.e-(' ~~-r't. s. Ellison ALSEP Reliability & Quality

  11. Impact of Concomitant Chemotherapy on Outcomes of Radiation Therapy for Head-and-Neck Cancer: A Population-Based Study

    SciTech Connect (OSTI)

    Gupta, Shlok; Kong, Weidong [Division of Cancer Care and Epidemiology, Queens Cancer Research Institute, Queens University, Kingston, Ontario (Canada); Booth, Christopher M. [Division of Cancer Care and Epidemiology, Queens Cancer Research Institute, Queens University, Kingston, Ontario (Canada); Department of Oncology, Queens University, Kingston, Ontario (Canada); Mackillop, William J., E-mail: william.mackillop@krcc.on.ca [Division of Cancer Care and Epidemiology, Queens Cancer Research Institute, Queens University, Kingston, Ontario (Canada); Department of Oncology, Queens University, Kingston, Ontario (Canada); Department of Community Health and Epidemiology, Queens University, Kingston, Ontario (Canada)

    2014-01-01T23:59:59.000Z

    Purpose: Clinical trials have shown that the addition of chemotherapy to radiation therapy (RT) improves survival in advanced head-and-neck cancer. The objective of this study was to describe the effectiveness of concomitant chemoradiation therapy (C-CRT) in routine practice. Methods and Materials: This was a population-based cohort study. Electronic records of treatment from all provincial cancer centers were linked to a population--based cancer registry to describe the adoption of C-CRT for head-and-neck cancer patients in Ontario, Canada. The study population was then divided into pre- and postadoption cohorts, and their outcomes were compared. Results: Between 1992 and 2008, 18,867 patients had diagnoses of head-and-neck cancer in Ontario, of whom 7866 (41.7%) were treated with primary RT. The proportion of primary RT cases that received C-CRT increased from 2.2% in the preadoption cohort (1992-1998) to 39.3% in the postadoption cohort (2003-2008). Five-year survival among all primary RT cases increased from 43.6% in the preadoption cohort to 51.8% in the postadoption cohort (P<.001). Over the same period, treatment-related hospital admissions increased significantly, but there was no significant increase in treatment-related deaths. Conclusions: C-CRT was widely adopted in Ontario after 2003, and its adoption was temporally associated with an improvement in survival.

  12. Approach for the 3D-alignment in micro-and nano-scale assembly processes

    E-Print Network [OSTI]

    Boyer, Edmond

    as known from the macro- and meso-scale. Although a lot of similarities exist for both regimes, micro to the f meso-scale p ly machine by human rt and the h her in positi owever, dep an be used outcome h

  13. des<

    E-Print Network [OSTI]

    Science,Uni Berkeley. 150VAX (750,780,785,86xx) 300 microVAX 3OOIBM RT 250 SUN 1 CRAY XMP/48 2 VAX 8650 CRAY et I'IBM 3090sontconnectésà un Hyperchannelet les front-end de cesma- chinessontdesVAX

  14. CMU-ITC-86-056 AFIPS Press

    E-Print Network [OSTI]

    of high powered work stations and personal computers. Currently, there are over 150 DEC VAX 750/780/785 class of computers on campus together with approximately 200 SUN's, 150 RT-PC's, 300 microVAX of machines above, only 6 DEC-20's, 3 VAX 780's, a 3083 and a number of PC and Macintosh clusters

  15. !iliii!i!i Machine-Independent Virtual Memory Management

    E-Print Network [OSTI]

    Arpaci-Dusseau, Remzi

    half a dozen uniprocessors and multiprocessors including the VAX family of uniproces- sors paging support. Versions of Berkeley UNIX on non-VAX hardware, such as SunOS on the SUN 3 and ACIS 4.2 on the IBM RT PC, actually simu- late internally the VAX memory mapping architecture -- in effect treating

  16. CMU-ITC-86-050 Design and Implementation of an Ubiquitous High Speed Communication Utility for

    E-Print Network [OSTI]

    computers. Currently, there are over 150 DEC VAX 750/780 computers on campus together with approximately 200 SUN's, 100 RT-PC's, 100 microVAX'es, 200 ICL Perq's, 50 DEC Pro 350's, 50 HP9836's, numerous DEC PDP-1 operates 6 DEC-20's, 5 VAX's and a recently acquired an IBM 3083. In 1982, CMU's commitment to distributed

  17. Physics 123 Equations Winter 2012 Semester I. Equations you should know by heart (but I'm giving them to you anyway)

    E-Print Network [OSTI]

    Hart, Gus

    = Qc/|W| Heat pump: COPHP = Qh/|W| Carnot: emax = (Th Tc)/Th; COPR,max = Tc/(Th Tc); COPHP,max = Th 2 + gy2 (Bernoulli's Law, from energy conservation) Thermodynamics PV = nRT = NkBT Equipartition exerted by balls (atoms) from change in momentum = area under P-V curve First Law: Eint = Qadded + Won

  18. GLY 5828, Assignment 2: 1. Describe Q, q, K, T, b, Darcy's law (in both the K and T forms), and mean pore

    E-Print Network [OSTI]

    Sukop, Mike

    GLY 5828, Assignment 2: 1. Describe Q, q, K, T, b, Darcy's law (in both the K and T forms? Assume no pumping and no impact of salt water intrusion. 3. Beginning with the 1-D Laplace equation ( 02. Repeat 3 but use the 1-D Poisson equation ( T R x h -= 2 2 ) with R/T = 0.001. Also solve

  19. Approximation of Axisymmetric Darcy Flow V.J. Ervin

    E-Print Network [OSTI]

    Ervin, Vincent J.

    approximation of the Darcy equations in an ax- isymmetric domain, subject to axisymmetric data. Rewriting of convergence for the RT and BDM approximations. Key words. axisymmetric flow; Darcy equation, LBB condition AMSApproximation of Axisymmetric Darcy Flow V.J. Ervin Department of Mathematical Sciences Clemson

  20. Eur. J. Phycol. (2006), 41: 97104 Simple and rapid RNA extraction from freeze-dried tissue

    E-Print Network [OSTI]

    Teixeira, Sara

    2006-01-01T23:59:59.000Z

    , macroarray hybridization, RT-PCR analysis, and cDNA library construction. This is often a challenge://www.marine-genomics- europe.org/index.php). In addition, there is a long history of research using fucoid zygotes as a model of these goals will require the development of high-throughput and cost-effective methods of sample processing