National Library of Energy BETA

Sample records for molecular biology csmb

  1. CSMB | Center for Structural Molecular Biology | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    it. The suite of tools being developed by the CSMB includes: Bio-SANS, a Small-Angle Neutron Scattering (SANS) facility for biological samples, has been completed at the ORNL...

  2. POSITION ANNOUNCEMENT Insect Molecular Biology

    E-Print Network [OSTI]

    Ishida, Yuko

    POSITION ANNOUNCEMENT Insect Molecular Biology 03/21/2014 POSITION: Research Associate LOCATION in entomology, biochemistry, molecular biology and/or toxicology; extensive research experience in entomology, biochemistry, cell biology and/or molecular biology; excellent organizational, and written and interpersonal

  3. Encyclopedia of Molecular Biology Thomas E. Creighton

    E-Print Network [OSTI]

    Oster, George

    Encyclopedia of Molecular Biology Thomas E. Creighton ISBN: 0-471-15302-8 ATP Synthase: Two rotary be divided into two operational regions denoted Encyclopedia of Molecular Biology, 4 Volume Set Thomas E

  4. LifeMEETSscience Biochemistry, Molecular Biology & Biophysics

    E-Print Network [OSTI]

    Thomas, David D.

    LifeMEETSscience Biochemistry, Molecular Biology & Biophysics Science Meets Life. Minnesota with the guidance of internationally-renowned scientists in the Biochemistry, Molecular Biology and Biophysics (BMBB that is a hallmark of the Twin Cities and Minnesota. The Biochemistry, Molecular Biology & Biophysics Graduate

  5. Molecular Biology The molecular biology major at Stetson University is designed for

    E-Print Network [OSTI]

    Miles, Will

    Molecular Biology The molecular biology major at Stetson University is designed for students interested in the interface between the life sciences and physical sciences. Molecular biology is an interdisciplinary science that uses the techniques of biology and chemistry to examine genetic inheritance

  6. BE.442 Molecular Structure of Biological Materials, Fall 2002

    E-Print Network [OSTI]

    Zhang, Shuguang, Dr.

    Basic molecular structural principles of biological materials. Molecular structures of various materials of biological origin, including collagen, silk, bone, protein adhesives, GFP, self-assembling peptides. Molecular ...

  7. BE.442 Molecular Structure of Biological Materials, Fall 2005

    E-Print Network [OSTI]

    Zhang, Shuguang, Dr.

    Basic molecular structural principles of biological materials. Molecular structures of various materials of biological origin, including collagen, silk, bone, protein adhesives, GFP, self-assembling peptides. Molecular ...

  8. Biochemistry & Molecular Biology Department of Environmental and Biomolecular Systems

    E-Print Network [OSTI]

    Chapman, Michael S.

    Biochemistry & Molecular Biology Department of Environmental and Biomolecular Systems Program Requirement Checklists Fall 2007 ­ Summer 2008 Master of Science ­ Biochemistry and Molecular Biology.............................................................2 Doctor of Philosophy ­ Biochemistry and Molecular Biology

  9. THE MOLECULAR BIOLOGY INSTITUTE AND THE DEPARTMENT OF CHEMISTRY & BIOCHEMISTRY

    E-Print Network [OSTI]

    Grether, Gregory

    THE MOLECULAR BIOLOGY INSTITUTE AND THE DEPARTMENT OF CHEMISTRY & BIOCHEMISTRY Three Nominees in Molecular Biology, Biochemistry and Chemistry at UCLA #12;

  10. Genetics and molecular biology of breast cancer

    SciTech Connect (OSTI)

    King, M.C. [California Univ., Berkeley, CA (United States); Lippman, M. [Georgetown Univ. Medical Center, Washington, DC (United States)] [comps.

    1992-12-31

    This volume contains the abstracts of oral presentations and poster sessions presented at the Cold Springs Harbor Meeting on Cancer Cells, this meeting entitled Genetics and Molecular Biology of Breast Cancer.

  11. Frontiers of NMR in Molecular Biology

    SciTech Connect (OSTI)

    NONE

    1999-08-25

    NMR spectroscopy is expanding the horizons of structural biology by determining the structures and describing the dynamics of blobular proteins in aqueous solution, as well as other classes of proteins including membrane proteins and the polypeptides that form the aggregates diagnostic of prion and amyloid diseases. Significant results are also emerging on DNA and RNA oligomers and their complexes with proteins. This meeting focused attention on key structural questions emanating from molecular biology and how NMR spectroscopy can be used to answer them.

  12. Molecular Mechanism of Biological Proton Transport

    SciTech Connect (OSTI)

    Pomes, R.

    1998-09-01

    Proton transport across lipid membranes is a fundamental aspect of biological energy transduction (metabolism). This function is mediated by a Grotthuss mechanism involving proton hopping along hydrogen-bonded networks embedded in membrane-spanning proteins. Using molecular simulations, the authors have explored the structural, dynamic, and thermodynamic properties giving rise to long-range proton translocation in hydrogen-bonded networks involving water molecules, or water wires, which are emerging as ubiquitous H{sup +}-transport devices in biological systems.

  13. Molecular Biology Basics Planning Restriction Enzyme Digests

    E-Print Network [OSTI]

    Aris, John P.

    Molecular Biology Basics Planning Restriction Enzyme Digests A. Checklist: Buffer type Addition of BSA Optimum temperature Number of units of enzyme B. Plan to digest DNA with an "excess" of enzyme activity. Plan for the "excess" to be divided between time of digestion and number of units of enzyme

  14. BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA

    E-Print Network [OSTI]

    Strynadka, Natalie

    BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA Announcement Course: Biochemistry 301, Biochemistry Laboratory Number of Positions: It is anticipated the supervision of a faculty member in the Department of Biochemistry and Molecular Biology, University of B

  15. BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA

    E-Print Network [OSTI]

    Strynadka, Natalie

    BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA Announcement, 2013 Course: Biochemistry 301, Biochemistry Laboratory Number of Positions: It is anticipated the supervision of a faculty member in the Department of Biochemistry and Molecular Biology, University of B

  16. Biochemistry and Molecular Biology Program College of Science and Management

    E-Print Network [OSTI]

    Northern British Columbia, University of

    FACH06-11 Biochemistry and Molecular Biology Program College of Science and Management Senior, in conjunction with the Biochemistry and Molecular Biology Program, invites applications for a full-time eight support for undergraduate courses in the Biochemistry and Molecular Biology major. Duties include

  17. 2011 Archaea: Ecology, Metabolism, & Molecular Biology

    SciTech Connect (OSTI)

    Keneth Stedman

    2011-08-05

    Archaea, one of three major evolutionary lineages of life, are a fascinating and diverse group of microbes with deep roots overlapping those of eukaryotes. The focus of the 'Archaea: Ecology Metabolism & Molecular Biology' GRC conference expands on a number of emerging topics highlighting new paradigms in archaeal metabolism, genome function and systems biology; information processing; evolution and the tree of life; the ecology and diversity of archaea and their viruses. The strength of this conference lies in its ability to couple a field with a rich history in high quality research with new scientific findings in an atmosphere of stimulating exchange. This conference remains an excellent opportunity for younger scientists to interact with world experts in this field.

  18. 2009 Archaea: Ecology, Metabolism & Molecular Biology GRC

    SciTech Connect (OSTI)

    Dr. Julie Maupin- Furlow

    2009-07-26

    Archaea, one of three major evolutionary lineages of life, are a fascinating and diverse group of microbes with deep roots overlapping those of eukaryotes. The focus of the 'Archaea: Ecology Metabolism & Molecular Biology' GRC conference expands on a number of emerging topics highlighting new paradigms in archaeal metabolism, genome function and systems biology; information processing; evolution and the tree of life; the ecology and diversity of archaea and their viruses; and industrial applications. The strength of this conference lies in its ability to couple a field with a rich history in high quality research with new scientific findings in an atmosphere of stimulating exchange. This conference remains an excellent opportunity for younger scientists to interact with world experts in this field.

  19. Modulhandbuch M.Sc. Biochemistry and Molecular Biology Title of the module Basics in biochemistry and molecular cell biology

    E-Print Network [OSTI]

    Diekmann, Martin

    Modulhandbuch M.Sc. Biochemistry and Molecular Biology Title of the module Basics in biochemistry and molecular cell biology Term/semester Winter term / 1 VAK-Number Will be assigned centrally Credit points 9 representative Prof. S. Kelm Instructors Prof. S. Kelm (Biochemistry), Prof. R. Stick (Cell Biology), Prof. A

  20. Modulhandbuch M.Sc. Biochemistry and Molecular Biology Title of the module Selected aspects of biochemistry and molecular biology

    E-Print Network [OSTI]

    Diekmann, Martin

    Modulhandbuch M.Sc. Biochemistry and Molecular Biology Title of the module Selected aspects of biochemistry and molecular biology Term/semester Summer term / 2 VAK-Number Credit points 6 ECTS Compulsory Instructors Prof. S. Kelm (Biochemistry), Prof. Stick (Cell Biology), Prof. R. Dringen (Biochemistry) Examiner

  1. Multispectral optical tweezers for molecular diagnostics of single biological cells

    E-Print Network [OSTI]

    Wu, Shin-Tson

    Multispectral optical tweezers for molecular diagnostics of single biological cells Author, Townes Laser Institute, CREOL ­ The College of Optics and Photonics, Univ. of Central Florida (United States) ABSTRACT Optical trapping of single biological cells has become an established technique

  2. Molecular & Cellular Biology Program Departmental Retreats Autumn 2014

    E-Print Network [OSTI]

    Doty, Sharon Lafferty

    Molecular & Cellular Biology Program Departmental Retreats ­ Autumn 2014 Z:\\FRONT DESK DOCUMENTS Hutchinson Cancer Research Center (FHCRC) 1100 Fairview Ave. N. Seattle, WA 98109-1024 Molecular & Cellular

  3. UBC Biochemistry Comprehensive Exam Guidelines Biochemistry and Molecular Biology

    E-Print Network [OSTI]

    Strynadka, Natalie

    UBC Biochemistry Comprehensive Exam Guidelines Biochemistry and Molecular Biology Comprehensive Examination Guidelines 20132014 #12;UBC Biochemistry Comprehensive Exam Guidelines Table #12;UBC Biochemistry Comprehensive Exam Guidelines

  4. Third international congress of plant molecular biology: Molecular biology of plant growth and development

    SciTech Connect (OSTI)

    Hallick, R.B.

    1995-02-01

    The Congress was held October 6-11, 1991 in Tucson with approximately 3000 scientists attending and over 300 oral presentations and 1800 posters. Plant molecular biology is one of the most rapidly developing areas of the biological sciences. Recent advances in the ability to isolate genes, to study their expression, and to create transgenic plants have had a major impact on our understanding of the many fundamental plant processes. In addition, new approaches have been created to improve plants for agricultural purposes. This is a book of presentation and posters from the conference.

  5. 2010 Plant Molecular Biology Gordon Research Conference

    SciTech Connect (OSTI)

    Michael Sussman

    2010-07-23

    The Plant Molecular Biology Conference has traditionally covered a breadth of exciting topics and the 2010 conference will continue in that tradition. Emerging concerns about food security have inspired a program with three main themes: (1) genomics, natural variation and breeding to understand adaptation and crop improvement, (2) hormonal cross talk, and (3) plant/microbe interactions. There are also sessions on epigenetics and proteomics/metabolomics. Thus this conference will bring together a range of disciplines, will foster the exchange of ideas and enable participants to learn of the latest developments and ideas in diverse areas of plant biology. The conference provides an excellent opportunity for individuals to discuss their research because additional speakers in each session will be selected from submitted abstracts. There will also be a poster session each day for a two-hour period prior to dinner. In particular, this conference plays a key role in enabling students and postdocs (the next generation of research leaders) to mingle with pioneers in multiple areas of plant science.

  6. Molecular Biology of the Cell Vol. 17, 52415252, December 2006

    E-Print Network [OSTI]

    Wessel, Gary M.

    Proteome after Self-AssociationD Julian L. Wong and Gary M. Wessel Department of Molecular BiologyMolecular Biology of the Cell Vol. 17, 5241­5252, December 2006 Rendezvin: An Essential Gene. On fertiliza- tion in sea urchins, the contents of cortical granules are secreted and rapidly assemble

  7. BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA

    E-Print Network [OSTI]

    Strynadka, Natalie

    BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA Announcement 12, 2013 Course: Biochemistry 421, Recombinant DNA Techniques Number of Positions: Three one the supervision of a faculty member in the Department of Biochemistry and Molecular Biology, University of B

  8. BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA

    E-Print Network [OSTI]

    Strynadka, Natalie

    BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA Announcement 1, 2014 Course: Biochemistry 421, Recombinant DNA Techniques Number of Positions: Three one the supervision of a faculty member in the Department of Biochemistry and Molecular Biology, University of B

  9. MOLECULAR CELL BIOLOGY: FALL SEMESTER, 2010 BIOL 213 SYLLABUS

    E-Print Network [OSTI]

    Summers, Max D.

    biotechnology, genetic engineering, M.D./Ph. D. programs or basic biological study and research. Honors MCB 213://www.tamu.edu/admissions/catalogs/ Benefit to students taking the The students will learn the basic details of molecular and course: cellularMOLECULAR CELL BIOLOGY: FALL SEMESTER, 2010 BIOL 213 SYLLABUS www.tamu.edu/summerslab/ I. Basic

  10. Biology BS, Molecular Cell Biology Emphasis, 2015-2016 Name ID# Date

    E-Print Network [OSTI]

    Barrash, Warren

    Biology BS, Molecular Cell Biology Emphasis, 2015-2016 Name ID# Date Course Number and Title 160 or MATH 170 4 DLN BIOL 191 General Biology I 4 DLN CHEM 111, 111L General Chemistry I with Lab 4 in a first field 3 DLS Social Sciences course in a second field 3 BIOL 192 General Biology II 4 BIOL 301 Cell

  11. Protein NMR Techniques, 3rd Methods in Molecular Biology, Springer Verlag (Humana Press), 2011

    E-Print Network [OSTI]

    Linsley, Braddock K.

    Protein NMR Techniques, 3rd ed. Methods in Molecular Biology, Springer Verlag (Humana Press), 2011, Methods in Molecular Biology Series, Springer Verlag (Humana Press), Winter 2011. #12;

  12. BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA

    E-Print Network [OSTI]

    Strynadka, Natalie

    BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA Announcement 12, 2013 Course: Biochemistry 302, General Biochemistry Number of Positions: It is anticipated: Application forms are available from Biochemistry website (www.biochem.ubc.ca) and should be submitted

  13. BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA

    E-Print Network [OSTI]

    Strynadka, Natalie

    BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA Announcement Course: Biochemistry 202, Introductory Medical Biochemistry Number of Positions: It is anticipated-II: $2,839.00 Application: Application forms are available from Biochemistry website (www

  14. BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA

    E-Print Network [OSTI]

    Strynadka, Natalie

    BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA Announcement Course: Biochemistry 410, General Biochemistry Number of Positions: one quarter time Qualifications-II: $2,839.00 Application: Application forms are available from Biochemistry website (www

  15. Taiwan International Graduate Program --Molecular and Biological Agricultural Sciences Introduction

    E-Print Network [OSTI]

    Taiwan International Graduate Program -- Molecular and Biological Agricultural Sciences Introduction Taiwan's academic interest in agricultural sciences began in earnest about 40 years ago with a breeding program in Taiwan's local rice varieties. Since then, various life science research institutes

  16. Progress in Biophysics and Molecular Biology 97 (2008) 115157 Scale relativity theory and integrative systems biology

    E-Print Network [OSTI]

    Nottale, Laurent

    2008-01-01

    Progress in Biophysics and Molecular Biology 97 (2008) 115­157 Review Scale relativity theory and integrative systems biology: 2 Macroscopic quantum-type mechanics Laurent Nottalea,b , Charles Auffrayb Meudon, France b Functional Genomics and Systems Biology for Health, UMR 7091-LGN, CNRS/Pierre & Marie

  17. BioFrameNet: A FrameNet Extension to the Domain of Molecular Biology

    E-Print Network [OSTI]

    Dolbey, Andrew

    2009-01-01

    Walter. 2002. Molecular Biology of the Cell. 4 th Edition.Natural Language Processing and Systems Biology. Artificialand Tools for Systems Biology: 147­174. Werner Dubitzky and

  18. MOLECULAR BIOLOGY AND BIOCHEMISTRY Introduction to Physical Biochemistry

    E-Print Network [OSTI]

    MOLECULAR BIOLOGY AND BIOCHEMISTRY MBB 323-3 Introduction to Physical Biochemistry DAY Fall 2007 theories of physics and chemistry, called thermodynamics, kinetics, and statistical mechanics, form for measuring physical properties of biological molecules are discussed, along with the models which

  19. Molecular Biology of the Cell Vol. 11, 14991507, May 2000

    E-Print Network [OSTI]

    Trask, Barbara Crippes

    that tropoelastin can self-assemble in vitro (Bressan et al., 1986; Vrhovski et al., 1997), it is generally acceptedMolecular Biology of the Cell Vol. 11, 1499­1507, May 2000 The Microfibrillar Proteins MAGP-1 proteins is important for elastic fiber assembly because inhibition of sulfation was shown to prevent

  20. Computational Molecular Biology of Genome Expression and Regulation

    E-Print Network [OSTI]

    Computational Molecular Biology of Genome Expression and Regulation Michael Q. Zhang, Ph.D. Cold in genome expression and regulation network in which better modern statistical and machine learning referring to the cellular processes that lead to pro- tein production, is controlled and regulated

  1. Computational approaches to discovering semantics in molecular biology

    SciTech Connect (OSTI)

    Lipton, R.J. ); Marr, T.G. . Theoretical Div.); Welsh, J.D. . Dept. of Biology)

    1989-07-01

    One of the central questions of molecular biology is the discovery of the semantics of DNA. This discovery relies in a critical way on a variety of expensive computations. In order to solve these computations, both parallel computers and special-purpose hardware play a major role.

  2. Genomics and computational molecular biology Douglas L Brutlag

    E-Print Network [OSTI]

    Brutlag, Doug

    340 Genomics and computational molecular biology Douglas L Brutlag There has been a dramatic increase in the number of completely sequenced bacterial genomes during the past two years as a result of the efforts both of public genome agencies and the pharmaceutical industry. The availability of completely

  3. BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA

    E-Print Network [OSTI]

    Strynadka, Natalie

    BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA Announcement Course: Biochemistry 203, Fundamentals of Biochemistry Number of Positions: It is anticipated-I: $2,950.36 GTA-II: $2,839.00 Application: Application forms are available from Biochemistry website

  4. BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA

    E-Print Network [OSTI]

    Strynadka, Natalie

    BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA Announcement Course: Biochemistry 203, Fundamentals of Biochemistry Number of Positions: It is anticipated,835.50 GTA-II: $2,728.50 Application: Application forms are available from Biochemistry website (www

  5. BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA

    E-Print Network [OSTI]

    Strynadka, Natalie

    BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA Announcement Course: Biochemistry 302, General Biochemistry Number of Positions: It is anticipated that the equivalent: Application forms are available from Biochemistry website (www.biochem.ubc.ca) and should be submitted

  6. Biochemistry and Molecular Biology PhD Comprehensive Exam

    E-Print Network [OSTI]

    Strynadka, Natalie

    Biochemistry and Molecular Biology PhD Comprehensive Exam Form One Suggested Examination Topics Examination Topics: 1) 2) 3) 4) 5) Suggested Examiners: 1) Dr. 2) Dr. 3) Dr. 4) Dr. #12;Biochemistry. Dr. 3. Dr. 4. Dr. Exam Chair #12;Biochemistry

  7. BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA

    E-Print Network [OSTI]

    Strynadka, Natalie

    BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA Announcement Course: Biochemistry 302, General Biochemistry Number of Positions: It is anticipated that the equivalent from Biochemistry website (www.biochem.ubc.ca) and should be submitted to Sabrina Cheng by February 28

  8. BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA

    E-Print Network [OSTI]

    Strynadka, Natalie

    BIOCHEMISTRY AND MOLECULAR BIOLOGY DEPARTMENT THE UNIVERSITY OF BRITISH COLUMBIA Announcement Course: Biochemistry 302, General Biochemistry Number of Positions: It is anticipated that the equivalent from Biochemistry website (www.biochem.ubc.ca) and should be submitted to Sabrina Cheng by March 11

  9. Review article Molecular biology of fish viruses: a review

    E-Print Network [OSTI]

    Boyer, Edmond

    Review article Molecular biology of fish viruses: a review J Bernard, M Brémont* INRA, laboratoire aspects in the fish virus studies. Although more than 50 different fish virus have been isolated family, the fish lym- phocystis disease virus (FLDV) is the most studied. Retroviridae have been recently

  10. Molecular Biology of the Cell Vol. 18, 24912502, July 2007

    E-Print Network [OSTI]

    Calvi, Brian R.

    are linked to other events that drive progression through the cell cycle by regulating the activityMolecular Biology of the Cell Vol. 18, 2491­2502, July 2007 Developmental and Cell Cycle Regulation zygotic histone transcription begins during nuclear cycle 11. Whereas the HLB is found in all cells after

  11. 10/29/12 EBS AY12/13 Biochemistry and Molecular Biology

    E-Print Network [OSTI]

    Chapman, Michael S.

    to Molecular Biology EBS 514 ­ Metabolism and Bioenergetics Advanced Elective Courses (16 credits, including EBS 514 ­ Metabolism and Bioenergetics Advanced Elective Courses (8 credits, including special topics 613 ­ Introduction to Molecular Biology EBS 614 ­ Metabolism and Bioenergetics Advanced Elec

  12. 4/30/13 EBS AY13/14 Biochemistry and Molecular Biology

    E-Print Network [OSTI]

    Chapman, Michael S.

    to Molecular Biology EBS 514 ­ Metabolism and Bioenergetics Advanced Elective Courses (16 credits, including EBS 514 ­ Metabolism and Bioenergetics Advanced Elective Courses (8 credits, including special topics 613 ­ Introduction to Molecular Biology EBS 614 ­ Metabolism and Bioenergetics Advanced Elective

  13. 12/15/11 EBS AY11/12 Biochemistry and Molecular Biology

    E-Print Network [OSTI]

    Chapman, Michael S.

    to Molecular Biology EBS 514 ­ Metabolism and Bioenergetics Advanced Elective Courses (16 credits, including EBS 514 ­ Metabolism and Bioenergetics Advanced Elective Courses (8 credits, including special topics 613 ­ Introduction to Molecular Biology EBS 614 ­ Metabolism and Bioenergetics Advanced Elec

  14. Revised 7/19/2011 B.S. Biochemistry and Molecular Biology Degree

    E-Print Network [OSTI]

    Microbiology 4 BL3300 Introduction to Genomics 3 BL4030 Molecular Biology 3 CH4995 Undergrad Research

  15. SUMMARY OF REQUIREMENTS FOR THE PH.D. IN MOLECULAR AND CELL BIOLOGY

    E-Print Network [OSTI]

    Snider, Barry B.

    SUMMARY OF REQUIREMENTS FOR THE PH.D. IN MOLECULAR AND CELL BIOLOGY The Graduate Committee: Bruce.D. students: Biol 103b (Mechanisms of Cell Function), Biol 105b (Molecular Biology) and Biol 200a (Proseminar-level) and be listed or cross-listed in the Molecular and Cell Biology section of the Brandeis Bulletin (http

  16. People and Progress 2013-2014 UConn Department of Molecular and Cell Biology

    E-Print Network [OSTI]

    Alpay, S. Pamir

    People and Progress 2013- 2014 UConn Department of Molecular and Cell Biology In this Issue of the Department of Molecular and Cell Biology, College of Liberal Arts and Sciences at the Univeristy about either publication to Department of Molecular & Cell Biology, University of Connecticut, 91 North

  17. Chemical Biology and Molecular Biophysics Program (CBMB) in Drug Discovery and Biotechnology

    E-Print Network [OSTI]

    Chen, Sheng-Wei

    Chemical Biology and Molecular Biophysics Program (CBMB) in Drug Discovery and Biotechnology-2014), and Director Ching-Shih Chen, the Chemical Biology and Molecular Biophysics Program in Drug Discovery their expertise. Starting in autumn 2009, the program is divided into two tracks: Chemical Biology (CB) track

  18. Multimedia in Biochemistry and Molecular Biology Education Proteopedia: 3D Visualization and Annotation of Transcription

    E-Print Network [OSTI]

    Rohs, Remo

    Multimedia in Biochemistry and Molecular Biology Education Proteopedia: 3D Visualization. Compeau§, and Remo Rohs From the Molecular and Computational Biology Program, Departments of Biological-DNA recognition, Hox, p53, DNA shape. Proteopedia is an online encyclopedia designed to illustrate the three

  19. 2012 PLANT MOLECULAR BIOLOGY GORDON RESEARCH CONFERENCE, JULY 15-20, 2012

    SciTech Connect (OSTI)

    Sussman, Michael

    2013-07-20

    The 2012 Gordon Conference on Plant Molecular Biology will present cutting-edge research on molecular aspects of plant growth and development, with particular emphasis on recent discoveries in molecular mechanisms involved with plant signaling systems. The Conference will feature a wide range of topics in plant molecular biology including hormone receptors and early events in hormone signaling, plant perception of and response to plant pathogen and symbionts, as well as technological and biological aspects of epigenomics particularly as it relates to signaling systems that regulate plant growth and development. Genomic approaches to plant signaling will be emphasized, including genomic profiling technologies for quantifying various biological subsystems, such as the epigenome, transcriptome, phosphorylome, and metabolome. The meeting will include an important session devoted to answering the question, "What are the biological and technological limits of plant breeding/genetics, and how can they be solved"?

  20. DBBS Alumni 1977 to 2011 Carl Parker, Ph.D. Molecular Biology Lab of Dr. Robert Roeder

    E-Print Network [OSTI]

    Gereau, Robert W. IV

    .D. Molecular Biology Lab of Dr. Rosalind R. Kornfeld David Cox, Ph.D. Evolutionary Biology and Ecology Lab. Valeriote Alfonso Gonzalez Noriega, Ph.D. Cellular, Developmental, & Systemic Biology Lab of Dr. William W. Barbara G. Pickard 1981 James Bartles, Ph.D. Molecular Biology Lab of Dr. William A. Frazier Stewart

  1. Collection Policy: BIOCHEMISTRY, MOLECULAR AND CELL BIOLOGY Subject Scope | Priority Tables | Other policies . . .

    E-Print Network [OSTI]

    Angenent, Lars T.

    Collection Policy: BIOCHEMISTRY, MOLECULAR AND CELL BIOLOGY Subject Scope | Priority Tables | Other The Section teaches courses on the following subjects: general biochemistry, bimolecular structure crystallography, ethical issues and professional responsibilities, and laboratory courses in biochemistry

  2. Mini-review Kaposi sarcoma-associated herpesvirus (KSHV): Molecular biology

    E-Print Network [OSTI]

    Damania, Blossom

    Mini-review Kaposi sarcoma-associated herpesvirus (KSHV): Molecular biology and oncogenesis Kwun in revised form 10 July 2009 Accepted 13 July 2009 Available online xxxx Keywords: KSHV Oncogenesis AIDS

  3. n. ISBN Title Subject 1 9780444519245 Comprehensive Molecular Insect Science Agricultural and Biological Sciences

    E-Print Network [OSTI]

    Malerba, Donato

    and Molecular Biology 21 9780080967011 Comprehensive Polymer Science Chemical Engineering 22 9780444531537 Comprehensive Semiconductor Science and Technology Chemical Engineering 23 9780444527455 Encyclopedia of Electrochemical Power Sources Chemical Engineering 24 9780080878621 Polymer Science: A Comprehensive Reference

  4. 2012 CELLULAR & MOLECULAR FUNGAL BIOLOGY GORDON RESEARCH CONFERENCE, JUNE 17 - 22, 2012

    SciTech Connect (OSTI)

    Judith Berman

    2012-06-22

    The Gordon Research Conference on CELLULAR & MOLECULAR FUNGAL BIOLOGY was held at Holderness School, Holderness New Hampshire, June 17 - 22, 2012. The 2012 Gordon Conference on Cellular and Molecular Fungal Biology (CMFB) will present the latest, cutting-edge research on the exciting and growing field of molecular and cellular aspects of fungal biology. Topics will range from yeast to filamentous fungi, from model systems to economically important organisms, and from saprophytes and commensals to pathogens of plants and animals. The CMFB conference will feature a wide range of topics including systems biology, cell biology and morphogenesis, organismal interactions, genome organisation and regulation, pathogenesis, energy metabolism, biomass production and population genomics. The Conference was well-attended with 136 participants. Gordon Research Conferences does not permit publication of meeting proceedings.

  5. Workshop in computational molecular biology, April 15, 1991--April 14, 1994

    SciTech Connect (OSTI)

    Tavare, S.

    1995-04-12

    Funds from this award were used to the Workshop in Computational Molecular Biology, `91 Symposium entitled Interface: Computing Science and Statistics, Seattle, Washington, April 21, 1991; the Workshop in Statistical Issues in Molecular Biology held at Stanford, California, August 8, 1993; and the Session on Population Genetics a part of the 56th Annual Meeting, Institute of Mathematical Statistics, San Francisco, California, August 9, 1993.

  6. Molecular Biology of the Cell Vol. 20, 29432953, June 15, 2009

    E-Print Network [OSTI]

    Hancock, William O.

    , play an inconsequential role in mediating MT bending in LLC-PK1 cells and that MT-based molecular mechanical forces control the spatial distribution of the MT array. INTRODUCTION Microtubules (MTs) are self-assemblingMolecular Biology of the Cell Vol. 20, 2943­2953, June 15, 2009 Anterograde Microtubule Transport

  7. BIOC 35400 Biochemistry: Molecular Biology of the Gene `The Central Dogma'

    E-Print Network [OSTI]

    BIOC 35400 ­ Biochemistry: Molecular Biology of the Gene `The Central Dogma' Spring 2014 Ithaca Description: Biochemistry is the study of the molecular basis for life processes. This course is an upper or research careers. In Biochemistry : Protein Structure & Function, we cover structures of major biomolecules

  8. Media Contacts: Molecular Biology Initiative, Georgia Southern University

    E-Print Network [OSTI]

    Hutcheon, James M.

    (biotechnology, chemistry, physics, biology, forensics), including applicable technology and math skills. "This-ready workforce needed to fill these jobs and we applaud them for standing out as leaders in Georgia's educational

  9. Molecular Biology of the Cell Vol. 12, 27562766, September 2001

    E-Print Network [OSTI]

    Shaw, Janet M.

    Sequence of the Dnm1p GTPase Regulates Self-Assembly and Controls a Rate-limiting Step in Mitochondrial assembles to form rings or collars that surround mitochondrial tubules. Based on previous findings, a K705AMolecular Biology of the Cell Vol. 12, 2756­2766, September 2001 The GTPase Effector Domain

  10. Computational Molecular Biology Biochem 218 BioMedical Informatics 231

    E-Print Network [OSTI]

    the names of the genes and enter them in Go Term Finder to discover common biological processes, common the Yeast Cell Cycle Database by first entering a single gene of interest to you and then clicking on select all co- expressed genes: http://genome-www.stanford.edu/cgi-bin/cellcycle/search · Collect all

  11. Recent advances in yeast molecular biology: recombinant DNA. [Lead abstract

    SciTech Connect (OSTI)

    Not Available

    1982-09-01

    Separate abstracts were prepared for the 25 papers presented at a workshop focusing on chromosomal structure, gene regulation, recombination, DNA repair, and cell type control, that have been obtained by experimental approaches incorporating the new technologies of yeast DNA transformation, molecular cloning, and DNA sequence analysis. (KRM)

  12. Critical Reviews in Biochemistry and Molecular Biology, 27(4,5):403-444 (1992) Aspects in Structural Studies on Ribosomes

    E-Print Network [OSTI]

    Yonath, Ada E.

    1992-01-01

    Critical Reviews in Biochemistry and Molecular Biology, 27(4,5):403-444 (1992) Aspects-9238/92/$.50 0 1992 by CRC Press, Inc. 403 Critical

  13. 12/13/11 EBS AY10/11 Biochemistry and Molecular Biology

    E-Print Network [OSTI]

    Chapman, Michael S.

    EBS 514 ­ Metabolism and Bioenergetics Advanced Elective Courses (16 credits, including special topics and Bioenergetics Advanced Elective Courses (8 credits, including special topics and independent studies): Reading to Molecular Biology EBS 614 ­ Metabolism and Bioenergetics Advanced Elective Courses (12 credits, including

  14. 2014NatureAmerica,Inc.Allrightsreserved. nature structural & molecular biology advance online publication

    E-Print Network [OSTI]

    Zhang, Yi

    ©2014NatureAmerica,Inc.Allrightsreserved. nature structural & molecular biology advance online building block of chromatin1. Assembly of genomic DNA into nucleosomes not only helps in storing genomic that nucleosome assembly is a prerequisite for functional nuclear-envelope (NE) formation and particularly

  15. 1238 | S. Bansal and A. Mittal Molecular Biology of the Cell MBoC | ARTICLE

    E-Print Network [OSTI]

    Mittal, Aditya

    lim- ited. Self-aggregation/assembly of amphipathic molecules was a crucial step in the origin of life1238 | S. Bansal and A. Mittal Molecular Biology of the Cell MBoC | ARTICLE A statistical anomaly evidence (to our knowledge) on the symbiotic origins of eukaryotic cells based on the "third front" (i

  16. MOLECULAR AND CELLULAR BIOLOGY, 0270-7306/99/$04.00 0

    E-Print Network [OSTI]

    MOLECULAR AND CELLULAR BIOLOGY, 0270-7306/99/$04.00 0 Dec. 1999, p. 8526­8535 Vol. 19, No. 12 show that the SCAN motif functions as an oligomerization domain mediating self an important role in the assembly and function of this newly defined subclass of transcriptional regulators

  17. Salt stress response in rice: genetics, molecular biology, and comparative genomics

    E-Print Network [OSTI]

    Blumwald, Eduardo

    REVIEW Salt stress response in rice: genetics, molecular biology, and comparative genomics Chandan. Evidence show that salt tolerance in plants is a quantitative trait. Several traditional cultivars materials for donation of requisite salt tolerance genes. A large number of quantitative trait loci (QTL

  18. Modules M.Sc. Biochemistry and Molecular Biology Titel of the module Development of Microbial Strains

    E-Print Network [OSTI]

    Diekmann, Martin

    Modules M.Sc. Biochemistry and Molecular Biology Titel of the module Development of Microbial Compulsory/ elective course Core elective course Teaching methods Method SWS CP Lecture Seminar Lab course 4 features. Adoption of methods and results from fundamental research with respect to industrial application

  19. Modules M.Sc. Biochemistry and Molecular Biology Title of module Recombinant proteins

    E-Print Network [OSTI]

    Diekmann, Martin

    Modules M.Sc. Biochemistry and Molecular Biology Title of module Recombinant proteins Term are to provide · a basic understanding of concepts in the design of constructs for recombinant proteins · develop, analytical electrophoresis, primer design · transformation and expression of proteins in bacterial

  20. Plant Molecular Biology 50: 803818, 2002. 2002 Kluwer Academic Publishers. Printed in the Netherlands.

    E-Print Network [OSTI]

    Korban, Schuyler S.

    Plant Molecular Biology 50: 803­818, 2002. © 2002 Kluwer Academic Publishers. Printed. Unfortunately, such markers are not available for most plant species, including woody perennial plants. Here, we, and provides a minimal tiling path of 16 contiguous and overlapping BAC clones, thus generating a sequence

  1. Plant Molecular Biology 43: 621633, 2000. Dirk Inz (Ed.), The Plant Cell Cycle.

    E-Print Network [OSTI]

    Murray, J.A.H.

    Plant Molecular Biology 43: 621­633, 2000. Dirk Inzé (Ed.), The Plant Cell Cycle. © 2000 Kluwer Academic Publishers. Printed in the Netherlands. 621 The role and regulation of D-type cyclins in the plant.murray@biotech.cam.ac.uk) Key words: D-type cyclins, differentiation, G1/S control, plant cell cycle, proliferation

  2. Plant Molecular Biology 37: 155169, 1998. 155 c 1998 Kluwer Academic Publishers. Printed in Belgium.

    E-Print Network [OSTI]

    Murray, J.A.H.

    Plant Molecular Biology 37: 155­169, 1998. 155 cć 1998 Kluwer Academic Publishers. Printed and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins Rachael Huntley1 in revised form 23 December 1997 Key words: evolution, G1-S control, plant cell cycle, retinoblastoma protein

  3. Plant Molecular Biology 53: 423442, 2003. 2003 Kluwer Academic Publishers. Printed in the Netherlands.

    E-Print Network [OSTI]

    Murray, J.A.H.

    Plant Molecular Biology 53: 423­442, 2003. © 2003 Kluwer Academic Publishers. PrintedInstitute of Plant Sciences, ETH Zürich, LFW E57.1, 8092 Zürich, Switzerland Received 28 July 2003; accepted cultures, transcript profiling Abstract Plant cell suspension cultures are invaluable models for the study

  4. DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY The University of British Columbia

    E-Print Network [OSTI]

    Strynadka, Natalie

    (over) DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY The University of British Columbia SUMMER/Eight-time: Undergraduate Biochemistry Training and Previous Experience (please see reverse) Degree(s) Obtained (Discipline outline of the University of B.C. Biochemistry 303 course is given below. Please outline all undergraduate

  5. DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY The University of British Columbia

    E-Print Network [OSTI]

    Strynadka, Natalie

    DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY The University of British Columbia WINTER SESSION. to Apr. Half-time TAs work both terms: Sep. to Apr.] Undergraduate Biochemistry Training and Previous;ONLY NEW APPLICANTS NEED COMPLETE THIS SECTION Brief outlines for the University of B.C. Biochemistry

  6. DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY The University of British Columbia

    E-Print Network [OSTI]

    Strynadka, Natalie

    DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY The University of British Columbia SPRING 2015 Biochemistry Training and Previous Experience (please see reverse) Degree(s) Obtained (Discipline, Place, Date for the University of B.C. Biochemistry 301 and 303 courses are given below. Please outline all undergraduate

  7. DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY The University of British Columbia

    E-Print Network [OSTI]

    Strynadka, Natalie

    (over) DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY The University of British Columbia SUMMER-time: Undergraduate Biochemistry Training and Previous Experience (please see reverse) Degree(s) Obtained (Discipline outline of the University of B.C. Biochemistry 303 course is given below. Please outline all undergraduate

  8. DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY The University of British Columbia

    E-Print Network [OSTI]

    Strynadka, Natalie

    DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY The University of British Columbia WINTER SESSION.] Undergraduate Biochemistry Training and Previous Experience (please see reverse) Degree(s) Obtained (Discipline outlines for the University of B.C. Biochemistry 301 and 303 courses are given below. Please outline all

  9. Methods in Molecular Biology: Protocols in Confocal microscopy Chapter 17. Live imaging of green fluorescent protein

    E-Print Network [OSTI]

    Haseloff, Jim

    , an accessory protein that accepts energy from aequorin and re-emits it as green light [8] . GFP is an extremelyMethods in Molecular Biology: Protocols in Confocal microscopy Chapter 17. Live imaging of green biologists won the lottery when it was demonstrated that green fluorescent protein (GFP), a kind gift from

  10. Exploring the free-energy landscapes of biological systems with steered molecular dynamics

    E-Print Network [OSTI]

    Chen, Liao Y.

    1 Exploring the free-energy landscapes of biological systems with steered molecular dynamics fluctuation-dissipation-theorem (BD -FDT) to accurately compute the free-energy profiles for several compute the free-energy profiles for all the afore-listed systems that represent various important aspects

  11. Facilities for exploring molecular biology databases on the Web: A comparative study

    SciTech Connect (OSTI)

    Markowitz, V.M.; Chen, I.M.A.; Kosky, A.S.; Szeto, E.

    1996-12-31

    We discuss criteria for evaluating and comparing the main facilities provided by molecular biology databases (MBDs) for exploring (that is, retrieving and interpreting data) on the Web. We use these criteria for examining the facilities supported by typical MBDs such as Genbank, AtDB, GSDB, GDB, and MGD (as of September 5, 1996). 19 refs.

  12. Biology & Biomedical Sciences ACADEMIC PROGRAM

    E-Print Network [OSTI]

    Gereau, Robert W. IV

    Biology & Biomedical Sciences ACADEMIC PROGRAM GUIDELINES Programs in Cell & Molecular Biology Developmental, Regenerative and Stem Cell Biology Molecular Cell Biology Molecular Genetics & Genomics Molecular Microbiology & Microbial Pathogenesis #12;PAGE 2 GUIDELINES TO THE PROGRAMS IN CELL AND MOLECULAR BIOLOGY

  13. Quantum Information Biology: from information interpretation of quantum mechanics to applications in molecular biology and cognitive psychology

    E-Print Network [OSTI]

    Masanari Asano; Irina Basieva; Andrei Khrennikov; Masanori Ohya; Yoshiharu Tanaka; Ichiro Yamato

    2015-03-09

    We discuss foundational issues of quantum information biology (QIB) -- one of the most successful applications of the quantum formalism outside of physics. QIB provides a multi-scale model of information processing in bio-systems: from proteins and cells to cognitive and social systems. This theory has to be sharply distinguished from "traditional quantum biophysics". The latter is about quantum bio-physical processes, e.g., in cells or brains. QIB models the dynamics of information states of bio-systems. It is based on the quantum-like paradigm: complex bio-systems process information in accordance with the laws of quantum information and probability. This paradigm is supported by plenty of statistical bio-data collected at all scales, from molecular biology and genetics/epigenetics to cognitive psychology and behavioral economics. We argue that the information interpretation of quantum mechanics (its various forms were elaborated by Zeilinger and Brukner, Fuchs and Mermin, and D' Ariano) is the most natural interpretation of QIB. We also point out that QBIsm (Quantum Bayesianism) can serve to find a proper interpretation of bio-quantum probabilities. Biologically QIB is based on two principles: a) adaptivity; b) openness (bio-systems are fundamentally open). These principles are mathematically represented in the framework of a novel formalism -- quantum adaptive dynamics which, in particular, contains the standard theory of open quantum systems as a special case of adaptivity (to environment).

  14. Small-angle Neutron Scattering for Molecular Biology: Basics and Instrumentation

    SciTech Connect (OSTI)

    Heller, William T [ORNL; Littrell, Ken [ORNL

    2009-01-01

    As researchers strive to understand the interplay between the complex molecular systems that make up living cells, tools for characterizing the interactions between the various players involved have developed. Small-angle neutron scattering (SANS) plays an important role in building a molecular-level understanding of the structures of macromolecular systems that make up cells. SANS is widely applicable to the study of biological structures including, but by no means limited to, protein-protein or protein-nucleic acid complexes, lipid membranes, cellular scaffolding, and amyloid plaques. Here, we present a brief description of the technique as it is commonly applied to the study of biological systems and an overview instrumentation that is available at the various facilities around the world.

  15. Molecular biology in marine science: Scientific questions, technological approaches, and practical implications

    SciTech Connect (OSTI)

    1994-12-31

    This report describes molecular techniques that could be invaluable in addressing process-oriented problems in the ocean sciences that have perplexed oceanographers for decades, such as understanding the basis for biogeochemical processes, recruitment processes, upper-ocean dynamics, biological impacts of global warming, and ecological impacts of human activities. The coupling of highly sophisticated methods, such as satellite remote sensing, which permits synoptic monitoring of chemical, physical, and biological parameters over large areas, with the power of modern molecular tools for ``ground truthing`` at small scales could allow scientists to address questions about marine organisms and the ocean in which they live that could not be answered previously. Clearly, the marine sciences are on the threshold of an exciting new frontier of scientific discovery and economic opportunity.

  16. Molecular Biology for the Environment: an EC-US hands-on Course in Environmental Biotechnology

    SciTech Connect (OSTI)

    Victor de Lorenzo; Juan Luis Ramos; Jerome Kukor; Gerben J. Zylstra

    2004-02-15

    One of the central goals of this activity is to bring together young scientists (at the late Ph.D. or early postdoctoral stages of their careers) in a forum that should result in future collaborations. The course is designed to give scientists hands-on experience in modern, up-to-date biotechnological methods at the interface between molecular biology and environmental biotechnology for the analysis of microorganisms and their activities with regard to the remediation of pollutants in the environment.

  17. Biochemistry and Molecular Biology -Bachelor of Science (SMBCUG) Total Credits Required: 128 Major Requirements -62 credits Concentration Requirements -29 credits

    E-Print Network [OSTI]

    Biochemistry and Molecular Biology - Bachelor of Science (SMBCUG) Total Credits Required: 128 Major University Chemistry II AND 3 CH4995 Undergraduate Research in Biochemistry OR 6 CH1161 University Chemistry

  18. Plant Molecular Biology 2008 Gordon Research Conference - July 13-18, 2008

    SciTech Connect (OSTI)

    Richard M. Amasino

    2009-08-28

    The Plant Molecular Biology Conference has traditionally covered a breadth of exciting topics and the 2008 conference will continue in that tradition. There will be sessions on metabolism; new methods to study genomes, proteomes and metabolomes; plant-microbe interactions; plant hormones; epigenetics. A new topic for the conference this year will be bioenergy. Thus this conference will bring together a range of disciplines to foster the exchange ideas and to permit the participants to learn of the latest developments and ideas in diverse areas of plant biology. The conference provides an excellent opportunity for individuals to discuss their research because additional speakers in each session will be selected from submitted abstracts. There will also be a poster session each day for a two-hour period prior to dinner.

  19. Modulhandbuch M.Sc. Biochemistry and Molecular Biology Title of the module Functional genomics of marine eukaryotes

    E-Print Network [OSTI]

    Diekmann, Martin

    Modulhandbuch M.Sc. Biochemistry and Molecular Biology Title of the module Functional genomics and functional genomics), Prof. Frickenhaus (Bioinformatic) Examiner Dr. U. John Objectives Consolidation genomics Development of the abilities to the experimental work and understanding in the field of functional

  20. Biological Journal of the Linnean Society (1998), 63: 367378. With 4 figures Herbivores and molecular clocks as tools in

    E-Print Network [OSTI]

    Thompson, John N.

    1998-01-01

    a powerful tool to historical plant biogeography. © 1998 The Linnean Society of London ADDITIONAL KEY WORDS and molecular clocks as tools in plant biogeography OLLE PELLMYR AND JAMES LEEBENS-MACK Department of Biology (Apiaceae) and the host-specific herbivore Greya powelli (Lepidoptera: Prodoxidae) in California

  1. Molecular Based Mathematical Biology Research Article DOI: 10.2478/mlbmb-2013-0005 MBMB 2012 90-108

    E-Print Network [OSTI]

    Lu, Benzhuo

    Computing, Institute of Computational Mathematics and Scientific/Engineering Computing, AcademyMolecular Based Mathematical Biology Research Article · DOI: 10.2478/mlbmb-2013-0005 · MBMB · 2012-relaxation techniques, the effective- ness of which on acceleration is shown by numerical tests. It is worth noting

  2. Molecular biology on a microfluidic chip This article has been downloaded from IOPscience. Please scroll down to see the full text article.

    E-Print Network [OSTI]

    Quake, Stephen R.

    Molecular biology on a microfluidic chip This article has been downloaded from IOPscience. Please:10.1088/0953-8984/18/18/S14 Molecular biology on a microfluidic chip Jong Wook Hong1,4 , Yan Chen2 Published 19 April 2006 Online at stacks.iop.org/JPhysCM/18/S691 Abstract We have developed microfluidic

  3. Biology

    E-Print Network [OSTI]

    Bailey, Charlotte M

    Nightty Enrichment} is a FREE tutoring program to neip students succeed in ?rst year. Biology science courses. CUSINE offers eyening tutoring right in your own ...

  4. Biological Sciences http://www.clas.wayne.edu/biology/

    E-Print Network [OSTI]

    Finley Jr., Russell L.

    Biological Sciences http://www.clas.wayne.edu/biology/ Divisions: Evolutionary and Organismal Biology Molecular Biology and Biotechnology Cellular, Developmental, and Neurobiology #12;Biological Sciences http://www.clas.wayne.edu/biology/ · Cell Biology and Cytogenetics (Beningo, Tucker, Greenberg

  5. Undergraduate Programs BIOCHEMISTRY & MOLECULAR

    E-Print Network [OSTI]

    Dellaire, Graham

    Undergraduate Programs in BIOCHEMISTRY & MOLECULAR BIOLOGY Dalhousie University 5850 College Street.............................................................................................................................. 3 1. Biochemistry Degree Programs .............................................................................................................. 4 Minor in Biochemistry & Molecular Biology

  6. Undergraduate Programs BIOCHEMISTRY & MOLECULAR

    E-Print Network [OSTI]

    Dellaire, Graham

    Undergraduate Programs in BIOCHEMISTRY & MOLECULAR BIOLOGY Dalhousie University 9B1 - 5850 College........................................................................................................................................................ 3 1. Biochemistry Degree Programs ............................................................................................................................. 5 Minor in Biochemistry & Molecular Biology

  7. Undergraduate Programs BIOCHEMISTRY & MOLECULAR

    E-Print Network [OSTI]

    Dellaire, Graham

    Undergraduate Programs in BIOCHEMISTRY & MOLECULAR BIOLOGY Dalhousie University 5850 College Street ............................................................................................................................. 3 1. Biochemistry Degree Programs .............................................................................................................. 4 Minor in Biochemistry & Molecular Biology

  8. WHOLE CELL TOMOGRAPHY/MOLECULAR BIOLOGY/STRUCTURAL BIOLOGY: Affordable x-ray microscopy with nanoscale resolution

    SciTech Connect (OSTI)

    Evans, James E.; Blackborow, Paul; Horne, Stephen J.; Gelb, Jeff

    2013-03-01

    Biological research spans 10 orders of magnitude from angstroms to meters. While electron microscopy can reveal structural details at most of these spatial length scales, transmission electron tomography only reliably reconstructs three-dimensional (3-D) volumes of cellular material with a spatial resolution between 1-5 nm from samples less than 500 nm thick1. Most biological cells are 2-30 times thicker than this threshold, which means that a cell must be cut into consecutive slices with each slice reconstructed individually in order to approximate the contextual information of the entire cell. Fortunately, due to a larger penetration depth2, X-ray computed tomography bypasses the need to physically section a cell and enables imaging of intact cells and tissues on the micrometer or larger scale with tens to hundreds of nanometer spatial resolution. While the technique of soft x-ray microscopy has been extensively developed in synchrotron facilities, advancements in laboratory x-ray source designs now increase its accessibility by supporting commercial systems suitable for a standard laboratory. In this paper, we highlight a new commercial compact cryogenic soft x-ray microscope designed for a standard laboratory setting and explore its capabilities for mesoscopic investigations of intact prokaryotic and eukaryotic cells.

  9. Journal of Biochemistry and Molecular Biology, Vol. 33, No. 6, November 2000, pp. 476-482 BSRK & Springer-Verlag 2000

    E-Print Network [OSTI]

    Park, Jong-Sang

    -Lysinamide-carbamoyl] cholesterol could self- assemble with plasmid DNA forming discrete lipoplexes. From atomic force microscopicJournal of Biochemistry and Molecular Biology, Vol. 33, No. 6, November 2000, pp. 476-482 © BSRK & Molecular Engineering, Seoul National University, San 56-1, Shillim-dong, Kwanak-ku, Seoul, 151-742, Korea

  10. Example 1 -LIFE SCIENCES/SCIENCES DE LA VIE Biology A Gene, Cell, Molecular

    E-Print Network [OSTI]

    Reid, Nancy

    Bacteriology, Virology, Protozoology Bioremediation, Environmental microbiology, Food microbiology Parasitology, Mycology) Link with ENG2 and ES6 for bioremediation LS7a Cellular and molecular Neuroscience Water and minerals in plants, Plant morphology, Nutrition and metabolism, Photosynthesis, Stress

  11. Biology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room News PublicationsAudits & InspectionsBeryllium andSamplerBiological Imaging byU.S.

  12. Studying chemical reactions in biological systems with MBN Explorer: implementation of molecular mechanics with dynamical topology

    E-Print Network [OSTI]

    Sushko, Gennady B; Verkhovtsev, Alexey V; Volkov, Sergey N; Solov'yov, Andrey V

    2015-01-01

    The concept of molecular mechanics force field has nowadays been widely accepted for studying various processes in biomolecular systems. In this paper we suggest a modification for the standard CHARMM force field, that permits simulations of systems with dynamically changing molecular topologies. The implementation of the modified force field was carried out in the popular program MBN Explorer, and, to support the development, in this paper we provide several case studies where dynamical topology is necessary. In particular, it is shown, that the modified molecular mechanics force field can be applied for studying processes where rupture of chemical bonds plays an essential role, e.g., in irradiation or collision induced damage, transformation and fragmentation processes involving biomolecular systems.

  13. Environmental Biology | Clean Energy | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    microbiology, biogeochemistry, molecular biology, molecular dynamics, bioinformatics, genomics, neutron science, chemistry, and computing-and spans multiple scales, from the...

  14. Postdoctoral position -UC Davis -plant-vector interactions, plant-microbe interactions, molecular biology, ecology

    E-Print Network [OSTI]

    Ishida, Yuko

    Postdoctoral position - UC Davis - plant-vector interactions, plant-microbe interactions, molecular August 2014. The primary research goal of the Casteel lab is to identify the functions of microbes- microbe or plant-insect interactions will be preferred. Candidates with a proven record of excellence

  15. Computational Biology | More Science | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Computational Biology SHARE Computational Biology Computational Biology research encompasses many important aspects including molecular biophysics for bio-energy, genetic level...

  16. From: Methods in Molecular Biology, vol. 350: Protein Folding Protocols Edited by: Y. Bai and R. Nussinov Humana Press Inc., Totowa, NJ

    E-Print Network [OSTI]

    Schuler, Ben

    115 From: Methods in Molecular Biology, vol. 350: Protein Folding Protocols Edited by: Y. Bai and R to Protein Folding Benjamin Schuler Summary Protein folding is a process characterized by a large degree this method to protein folding. Key Words: Protein folding; fluorescence spectroscopy; single molecule

  17. From: Methods in Molecular Biology, vol. 350: Protein Folding Protocols Edited by: Y. Bai and R. Nussinov Humana Press Inc., Totowa, NJ

    E-Print Network [OSTI]

    Caflisch, Amedeo

    225 From: Methods in Molecular Biology, vol. 350: Protein Folding Protocols Edited by: Y. Bai and R in the transition state. Key Words: Protein folding; energy landscape; transition state ensemble; denatured state- sively applied to the analysis of protein folding (1­5). Although proteins are essential macromolecules

  18. MOLECULAR AND CELLULAR BIOLOGY, 0270-7306/01/$04.00 0 DOI: 10.1128/MCB.21.20.68206832.2001

    E-Print Network [OSTI]

    MOLECULAR AND CELLULAR BIOLOGY, 0270-7306/01/$04.00 0 DOI: 10.1128/MCB.21.20.6820­6832.2001 Oct. 2001, p. 6820­6832 Vol. 21, No. 20 Copyright © 2001, American Society for Microbiology. All Rights Laboratory, Cold Spring Harbor, New York2 Received 9 May 2001/Returned for modification 25 June 2001/Accepted

  19. Biology & Biomedical Sciences ACADEMIC PROGRAM

    E-Print Network [OSTI]

    Gereau, Robert W. IV

    Biology & Biomedical Sciences ACADEMIC PROGRAM GUIDELINES Programs in Cell & Molecular Biology Molecular Microbiology & Microbial Pathogenesis Overview of the Programs in Cell and Molecular Biology Graduate training in Cell and Molecular Biology at Washington University is offered by the Programs in Cell

  20. Resource Letter: Bio-molecular Nano-machines: where Physics, Chemistry, Biology and Technology meet

    E-Print Network [OSTI]

    Debashish Chowdhury

    2008-07-17

    Cell is the structural and functional unit of life. This Resource Letter serves as a guide to the literature on nano-machines which drive not only intracellular movements, but also motility of the cell. These machines are usually proteins or macromolecular assemblies which require appropriate fuel for their operations. Although, traditionally, these machines were subjects of investigation in biology and biochemistry, increasing use of the concepts and techniques of physics in recent years have contributed to the quantitative understanding of the fundamental principles underlying their operational mechanisms. The possibility of exploiting these principles for the design and control of artificial nano-machines has opened up a new frontier in the bottom-up approach to nano-technology.

  1. Systems biology of the cardiac hypoxia response in Drosophila

    E-Print Network [OSTI]

    Feala, Jacob Daniel

    2008-01-01

    in Molecular Systems Biology , volume 3, article number 99,appear in Molecular Systems Biology. The dissertation authoret al. (2003) The systems biology markup language (SBML): a

  2. FINAL REPORT: DOE CONTRACT NUMBER FG0205ER64026 Biological Neutron Scattering: A Collaboration with the Oak Ridge Center for Structural Molecular Biology

    SciTech Connect (OSTI)

    Jill Trewhella

    2011-01-12

    The overarching goal of this project was to promote applications of small-angle scattering in structural molecular biology by providing model examples of cutting edge applications that demonstrate the unique capabilities and potential of the DOE national user facilities at Oak Ridge, especially the newly commissioned BioSANS. The approach taken was three-fold: (1) to engage in high impact collaborative research projects that would benefit from small-angle neutron scattering to both demonstrate the power of the technique while expanding the potential user community; (2) to provide access to scattering facilities established at the University of Utah to as broad a set of researchers as possible to increase the expertise in small-angle scattering generally; and (3) to develop new methods and tools for small-angle scattering. To these ends, three major research collaborations were pursued that resulted in a significant body of published work where neutron scattering and contrast variation played a major role. These major collaborations involved studies of protein complexes involved in (1) bacterial transcription regulation and adaptive response (a DOE/BER priority area); (2) regulation of cardiac muscle; and (3) neuronal disorders. In addition, to broaden the impact of the project, smaller collaborative efforts were supported that used either small-angle X-ray or neutron scattering. Finally, the DOE supported facilities at the University of Utah were made available to researchers on a service basis and a number of independent groups took advantage of this opportunity. In all of this work, there was an emphasis on the training of students and post docs in scattering techniques, and a set of publications (a book chapter, a review, and an encyclopedia article) were produced to guide the non-specialist potential user of scattering techniques in successful applications of the techniques. We also developed a suite of user friendly web-based computational tools currently being accessed world-wide by researchers as an aid in neutron scattering data interpretation. In all, these collaborative projects and resulted in 29 original refereed journal articles published between 2005 and 2010 and engaged groups from at least 14 Universities (10 US, 4 international) and 3 National Laboratories (2 US, 1 international). An important final initiative from this project was to begin a process for international community agreement on a set of standards for the publication of biomolecular small-angle scattering data. This initiative is being championed with the International Union of Crystallography and has engaged a number of Journal Editors and is a very important step in the maturing of this now burgeoning field.

  3. Biology is the study of life. Biologists analyze how systems function in organisms at the cellular and molecular levels

    E-Print Network [OSTI]

    Saldin, Dilano

    Biology is the study of life. Biologists analyze how systems function in organisms at the cellular and public sectors. People with degrees in biology are needed in areas as diverse as farming, food processing, and the environment, as well as in the biomedical and biotechnology fields. A degree in biology can also be used

  4. Encounter with Molecular Biology

    E-Print Network [OSTI]

    Macfarlane, Alan

    2014-12-12

    aged fifteen; commuted every day, by bicycle, train, then walking; tough regime with lectures or laboratory sessions every day including Saturday morning from 8am; enjoyed it as there did meet interesting people; a man in the botany department...

  5. Encounter with Molecular Biology

    E-Print Network [OSTI]

    Macfarlane, Alan

    2014-08-28

    how you could put them back together again; went to University of Witwatersrand aged fifteen; commuted every day, by bicycle, train, then walking; tough regime with lectures or laboratory sessions every day including Saturday morning from 8am...

  6. Structural Molecular Biology, SSRL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation ofAlbuquerque|SensitiveAprilPhoton SourceSuperconductors

  7. Structural Molecular Biology, SSRL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effect Photovoltaics -7541C.3X-rays3EnergyParameter SpecificationsInsights

  8. Structural Molecular Biology, SSRL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effect Photovoltaics -7541C.3X-rays3EnergyParameter SpecificationsInsightsOur

  9. Structural Molecular Biology, SSRL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effect Photovoltaics -7541C.3X-rays3EnergyParameter

  10. BIOLOGY, B.S. WITH TEACHER CERTIFICATE Biology (BIOT)

    E-Print Network [OSTI]

    Hamburger, Peter

    BIOLOGY, B.S. WITH TEACHER CERTIFICATE Biology (BIOT) (Fall 2015-Summer 2016) IPFW Residency/Gen Ed Biology BS Core/Supporting Courses (64 credits) *Note: 3.0 GPA required in Biology Core 21800 Genetics & Molecular Biology ______ 4 BIOL 21900 Principles of Functional Biology ______ 3 BIOL

  11. NATURE STRUCTURAL & MOLECULAR BIOLOGY VOLUME 16 NUMBER 12 DECEMBER 2009 1267 A RT I C L E S

    E-Print Network [OSTI]

    Chou, James

    of BM2 is also a coiled-coil tetramer, and its unusually large electrostatic dipole moment suggests-coil tetramer with a packing angle of about -37° (Fig. 1a). The tetramer has a well 1Department of Biological

  12. Cellular and Molecular BiologyTM 52, N6,47-52 ISSN 1165-158X

    E-Print Network [OSTI]

    Boyer, Edmond

    an impaired trafficking of Cx43 proteins in early carcinogenesis. In collaboration with biologists, we propose and the statistical validation of biological hypotheses about Cx43 expressions and configurations during tumorogenesis connexins (Cx), among which Cx43 is the most representative in mammalians. Recently, impaired GJC and Cx

  13. Authors' pre-print version. Manuscript published in Molecular Biology and Evolution MBE-13-0254.R2

    E-Print Network [OSTI]

    Gogarten, J. Peter

    of Connecticut, Storrs, Connecticut, United States of America 2 University of Connecticut Biotechnology Center, University of Connecticut, Storrs, Connecticut, United States of America 3 Current affiliation: Department of Cell Biology, Yale University Medical School, New Haven, Connecticut, United States of America 4

  14. A R T I C L E S NATURE STRUCTURAL & MOLECULAR BIOLOGY VOLUME 11 NUMBER 8 AUGUST 2004 721

    E-Print Network [OSTI]

    Berger, James M.

    in the plant pathogen Xanthomonas oryzae, suggesting a role for sul- fated metabolites in plant), to carbohydrates, proteins and a variety of other low-molecular-mass metabolites3­5. Just as kinases are of consid and physiological substrates. Cytosolic STs add sulfate to steroids and other small hydrophobic metabolites, whereas

  15. B.S. Biochemistry Planning Worksheet. Updated 09/06 Bachelor of Science Biochemistry and Molecular Biology Requirements (BIOC)

    E-Print Network [OSTI]

    Adali, Tulay

    B.S. Biochemistry Planning Worksheet. Updated 09/06 Bachelor of Science Biochemistry and Molecular Biochemistry (12 credits; all upper-level) CHEM 437 Comprehensive Biochem I* BIOL 100, CHEM 352 4 F CHEM 437L Biochemistry Laboratory* CHEM 352L; 437 (pre- or co-req) 4 FS CHEM 438 Comprehensive Biochem II* CHEM 437 4

  16. 7.013 Introductory Biology, Spring 2005

    E-Print Network [OSTI]

    Sive, Hazel L.

    The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological ...

  17. Biological Science courses BE 513 Molecuar and Celluar Biology

    E-Print Network [OSTI]

    Fang-Yen, Christopher

    Biological Science courses BE 513 Molecuar and Celluar Biology BE 555 Nanoscale Systems Biology. BIOM 501 Mechanisms of Disease and Therapeutic BIOM 600 Cell Biology BMB 508 Molecular Biophysics I BMB 509 Macromolecular Biophysics II BMB 567 Bioinorganic Chemistry BMB 590 Biological Physics BMB 614

  18. BIOLOGY SEMINAR PROMOTION LECTURE

    E-Print Network [OSTI]

    Shlizerman, Eli

    BIOLOGY SEMINAR PROMOTION LECTURE 12:00 PM SEMINAR HITCHCOCK HALL 132 REFRESHMENTS SERVED IN FOYER, November 24, 2014 "Life is flux" Dr. Jennifer Nemhauser Associate Professor Department of Biology drawn from molecular genetics, genomics, physiology and synthetic biology to build new tools to study

  19. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, Sept. 2004, p. 403431 Vol. 68, No. 3 1092-2172/04/$08.00 0 DOI: 10.1128/MMBR.68.3.403431.2004

    E-Print Network [OSTI]

    McFall-Ngai, Margaret

    MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, Sept. 2004, p. 403­431 Vol. 68, No. 3 1092-2172/04/$08.00 0 DOI: 10.1128/MMBR.68.3.403­431.2004 Copyright © 2004, American Society for Microbiology. All.........................................................................................................403 OCCURRENCE AND IMPORTANCE

  20. 7.012 Introduction to Biology, Fall 2001

    E-Print Network [OSTI]

    Weinberg, Robert A. (Robert Allan), 1942-

    Cell biology, immunology, neurobiology, and an exploration into current research in cancer, genomics, and molecular medicine.

  1. Quantum Biology

    E-Print Network [OSTI]

    Alessandro Sergi

    2009-07-11

    A critical assessment of the recent developments of molecular biology is presented. The thesis that they do not lead to a conceptual understanding of life and biological systems is defended. Maturana and Varela's concept of autopoiesis is briefly sketched and its logical circularity avoided by postulating the existence of underlying {\\it living processes}, entailing amplification from the microscopic to the macroscopic scale, with increasing complexity in the passage from one scale to the other. Following such a line of thought, the currently accepted model of condensed matter, which is based on electrostatics and short-ranged forces, is criticized. It is suggested that the correct interpretation of quantum dispersion forces (van der Waals, hydrogen bonding, and so on) as quantum coherence effects hints at the necessity of including long-ranged forces (or mechanisms for them) in condensed matter theories of biological processes. Some quantum effects in biology are reviewed and quantum mechanics is acknowledged as conceptually important to biology since without it most (if not all) of the biological structures and signalling processes would not even exist. Moreover, it is suggested that long-range quantum coherent dynamics, including electron polarization, may be invoked to explain signal amplification process in biological systems in general.

  2. Monte Carlo simulation in systems biology

    E-Print Network [OSTI]

    Schellenberger, Jan

    2010-01-01

    2 The history of Monte Carlo Sampling in Systems Biology 1.1simulation tools: the systems biology workbench and biospiceCellular and Molecular Biology. ASM Press, Washington

  3. Report on the research conducted under the funding of the Sloan foundation postdoctoral fellowship in Computational Molecular Biology [Systematic study of protein-protein complexes] Final report

    SciTech Connect (OSTI)

    Sheinerman, Felix

    2001-06-01

    A central question in molecular biology is what structural features are common at protein-protein interfaces and what energetic factors define the affinity and specificity of protein-protein association. Analysis of structural and mutational data on protein-protein interfaces revealed that protein-protein interfaces of different functional classes contain many more energetically important charged and polar residues than was previously thought. Since, in the context of protein folding studies, polar interactions are believed to destabilize the folded proteins, this observation raised the question as to the forces that determine the stability of protein complexes. To investigate this issue in detail, the authors developed a number of partitioning schemes that allowed them to investigate the role of selected residues, ion pairs, and networks of polar interactions in protein-protein association. The methods developed were applied to the analysis of four different protein-protein interfaces: the ribonuclease barnase and its inhibitor barstar, the human growth hormone and its receptor, subtype N9 influenze virus neuraminidase and NC41 antibody, and the Ras Binding Domain of kinase cRaf and a Ras homologue Rap1A. The calculations revealed a surprising variability in how polar interactions affect the stability of different complexes. The finding that positions of charged and polar residues on protein-protein interfaces are optimized with respect to electrostatic interactions suggests that this property can be employed for the discrimination between native conformations and trial complexes generated by a docking algorithm. Analysis indicated the presence of SH2 domains in Janus family of non-receptor protein tyrosine kinases.

  4. Eric Bennett Computational Molecular Biology

    E-Print Network [OSTI]

    they are built up from -strands perpendicular and parallel to the main fiber axis (10-11). It appears in the protein folding pathway have been shown to decrease the cell's ability to clear cellular waste leading

  5. Stacy Evans Computational Molecular Biology

    E-Print Network [OSTI]

    genome project, genes horizontally and laterally gene transferred have been implicated as the source of bacterial protein homologs in the human genome. Additionally, similar protein homologs have been identified to determine HT genes. For instance, original work conducted in 2001 by the human genome sequencing effort

  6. Marine Biology

    E-Print Network [OSTI]

    Zaffino, Kyle

    2013-01-01

    this  door. ”   Marine  Biology   I  joined  the  military  RIVERSIDE   Marine  Biology   A Thesis submitted in partialBiology                                                                                                                        

  7. Molecular and biological characterization of the 5 human-bovine rotavirus (WC3)-based reassortant strains of the pentavalent rotavirus vaccine, RotaTeq (registered)

    SciTech Connect (OSTI)

    Matthijnssens, Jelle; Joelsson, Daniel B.; Warakomski, Donald J.; Zhou, Tingyi; Mathis, Pamela K.; Maanen, Marc-Henri van; Ranheim, Todd S.; Ciarlet, Max

    2010-08-01

    RotaTeq (registered) is a pentavalent rotavirus vaccine that contains five human-bovine reassortant strains (designated G1, G2, G3, G4, and P1) on the backbone of the naturally attenuated tissue culture-adapted parental bovine rotavirus (BRV) strain WC3. The viral genomes of each of the reassortant strains were completely sequenced and compared pairwise and phylogenetically among each other and to human rotavirus (HRV) and BRV reference strains. Reassortants G1, G2, G3, and G4 contained the VP7 gene from their corresponding HRV parent strains, while reassortants G1 and G2 also contained the VP3 gene (genotype M1) from the HRV parent strain. The P1 reassortant contained the VP4 gene from the HRV parent strain and all the other gene segments from the BRV WC3 strain. The human VP7s had a high level of overall amino acid identity (G1: 95-99%, G2: 94-99% G3: 96-100%, G4: 93-99%) when compared to those of representative rotavirus strains of their corresponding G serotypes. The VP4 of the P1 reassortant had a high identity (92-97%) with those of serotype P1A[8] HRV reference strains, while the BRV VP7 showed identities ranging from 91% to 94% to those of serotype G6 HRV strains. Sequence analyses of the BRV or HRV genes confirmed that the fundamental structure of the proteins in the vaccine was similar to those of the HRV and BRV references strains. Sequences analyses showed that RotaTeq (registered) exhibited a high degree of genetic stability as no mutations were identified in the material of each reassortant, which undergoes two rounds of replication cycles in cell culture during the manufacturing process, when compared to the final material used to fill the dosing tubes. The infectivity of each of the reassortant strains of RotaTeq (registered) , like HRV strains, did not require the presence of sialic acid residues on the cell surface. The molecular and biologic characterization of RotaTeq (registered) adds to the significant body of clinical data supporting the consistent efficacy, immunogenicity, and safety of RotaTeq (registered) .

  8. Systems Biology Approaches Investigating Cardiac Epigenome Dynamics in Heart Hypertrophy and Failure

    E-Print Network [OSTI]

    Chen, Haodong

    2013-01-01

    reviews. Molecular cell biology 11, 264–75 (2010). Cairns,structural & molecular biology 18, 107–14 Li, G. et al.data. PLoS computational biology 5, e1000598 (2009).

  9. Current Biology, Vol. 13, 448453, March 4, 2003, 2003 Elsevier Science Ltd. All rights reserved. PII S0960-9822(03)00128-3 Molecular Genetics and Evolution

    E-Print Network [OSTI]

    Eizirik, Eduardo

    . PII S0960-9822(03)00128-3 Molecular Genetics and Evolution of Melanism in the Cat Family cat (Felis catus) is inherited as a recessive trait, sug- gesting agouti/ASIP as a candidate gene [1, 2], whereas

  10. The Science Institutes at Yale's West Campus Chemical Biology Cancer Biology Energy Sciences Microbial Diversity Nanobiology Systems Biology

    E-Print Network [OSTI]

    The Science Institutes at Yale's West Campus Chemical Biology Cancer Biology Energy Sciences Microbial Diversity Nanobiology Systems Biology The Chemical Biology Institute at Yale's West Campus #12 and molecular assem- blies, large and small, to address challenging problems in health, energy

  11. MASTER OF SCIENCE STUDIES IN BIOLOGY

    E-Print Network [OSTI]

    Hong, Don

    Ver. 1.15 MASTER OF SCIENCE STUDIES IN BIOLOGY GUIDE FOR APPLICANTS, GRADUATE STUDENTS AND GRADUATE Biology and Ecology Physiology and Cellular/Molecular Biology Research Tools COURSE LOADS AND RECOMMENDED.......................................................................................................................................12 Change of Thesis Advisor Registration for Biological Research Thesis Proposal Registration

  12. Biosensors combine the high selectivity and sensitivity of molecular recognition processes of biologi-cal macromolecules with a transducer. The increase in mass by the recognition process can in princi-

    E-Print Network [OSTI]

    Turova, Varvara

    Biosensors combine the high selectivity and sensitivity of molecular recognition processes. Keywords: biosensor, linear electro-elasticity, multi-layer structure, fluid-structure interaction, finite for Sensors and Actuators Modeling and Simulation Wave Propagation in Biosensors K.-H. Hoffmann N. Botkin, M

  13. From Tucson to Genomics and Transgenics: The Vector Biology Network and the Emergence of Modern Vector Biology

    E-Print Network [OSTI]

    2009-01-01

    mosquitoes. A PL meeting at the Biology of Disease Vectors (as a tool in vector biology. Transformation of the vector ofelement. Insect Molecular Biology 10: 597–604. 11. Balter

  14. Mol. Biol. Evol. 17(12):17761788. 2000 2000 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038

    E-Print Network [OSTI]

    Pollock, David

    and Evolution. ISSN: 0737-4038 A Case for Evolutionary Genomics and the Comprehensive Examination of Sequence; Department of Biological Sciences, Louisiana State University at Baton Rouge; Institute for Genomic Research, Gaithersburg, Maryland; §Genomics Group, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New

  15. Asymptotic Analysis of Cooperative Molecular Motor System

    E-Print Network [OSTI]

    Durrett, Richard

    McKinley1,4, John Fricks1,5 1Statistical and Applied Mathematical Sciences Institute 2Rensselaer Biological engines which catabolize ATP (fuel) to do useful work in a biological cell. Molecular pumps

  16. Mapping molecular dynamics computations to hypercubes 

    E-Print Network [OSTI]

    Lakamsani, Vamsee Krishna

    1993-01-01

    This thesis proposes an approach for systematic modeling, mapping and performance analysis of a Grand Challenge application problem in computational biology called Molecular Dynamics Simulation of Proteins. Molecular Dynamics (MD) is an important...

  17. Biology 2250 Principles of Genetics

    E-Print Network [OSTI]

    Innes, David J.

    . David J. Innes B MendelianGenetics Tentative Lecture Dates and Topics Carr: Sept. 14 - 30 Structure1 Biology 2250 Principles of Genetics Instructors: Dr. Steven M. Carr B Molecular Genetics Dr and function of DNA and genes Innes: Oct. 7 ­ Nov. 12 Mendelian Genetics Carr: Nov. 18 ­ Dec. 2 Molecular

  18. Graduate Programs in Plant Biology and

    E-Print Network [OSTI]

    Wildermuth, Mary C

    not re- biochemistry, cell and molecular biology (B22). pmb.berkeley.edu Plant&Microbial Biology #12;The to the environment will continue to fuel the expansion of plant research well into the future. The plant biology program focuses on contemporary ba- sic plant research, design of biotechnologies, and plant-microbe

  19. FACULTY EMPLOYMENT OPPORTUNITY DEPARTMENT OF BIOLOGY

    E-Print Network [OSTI]

    Ravikumar, B.

    OF BIOLOGY Permanent Full-Time Position (Tenure-Track) Assistant Professor Starting mid-August 2014 REFER of Biology at Sonoma State University seeks applications from broadly trained biologists with teaching and research interests and expertise in molecular biology, for a tenure-track Assistant Professor position

  20. Assessing computational methods and science policy in systems biology

    E-Print Network [OSTI]

    Castillo, Andrea R. (Andrea Redwing)

    2009-01-01

    In this thesis, I discuss the development of systems biology and issues in the progression of this science discipline. Traditional molecular biology has been driven by reductionism with the belief that breaking down a ...

  1. Systems biology analysis of Escherichia coli for discovery and metabolic engineering

    E-Print Network [OSTI]

    Orth, Jeffrey David

    2012-01-01

    the unification of biology. The Gene Ontology Consortium.cellular and molecular biology. 2nd ed. 1996, ASM Press:Journal of Theoretical Biology, 1993. 165(4): p. 503- Feist,

  2. Navigation Links Biology News

    E-Print Network [OSTI]

    Espinosa, Horacio D.

    Navigation Links Biology News Medicine News Biology Products Medicine Products Biology Definition Medicine Definition Biology Technology Medicine Technology Biology Dictionary Medicine Dictionary Biology Navigation Medical Navigation MHOME >> BIOLOGY >> NEWS Single-cell transfection tool enables added control

  3. Modular languages for systems and synthetic biology 

    E-Print Network [OSTI]

    Pedersen, Michael

    2010-01-01

    Systems biology is a rapidly growing field which seeks a refined quantitative understanding of organisms, particularly studying how molecular species such as metabolites, proteins and genes interact in cells to form the ...

  4. MOLECULAR AND COMPUTATIONAL BIOLOGY Department of Biological Sciences

    E-Print Network [OSTI]

    Rohs, Remo

    Year Initiation of dissertation research by the first summer. 6. 2nd /3rd Year Completion of other required coursework. 7. 2nd /3rd Year Complete Written Qualifying Exam; pass by end of first semester of 3rd year. 8. 2nd /3rd Year Complete Oral Qualifying Examination; pass by end of first semester of 3rd

  5. molecular BIologY Long RNAs turn up gene expression

    E-Print Network [OSTI]

    Suslick, Kenneth S.

    individual parts of the mitotic apparatus, the researchers surmise that, in the absence of spindles as 2 parts per billion. They show that, in a gas flow treated with a solid acid catalyst, TATP. Chem. Soc. doi:10.1021/ ja107419t (2010) PHYsIcs Insulator insight into constant Enigmatic materials

  6. Biological Safety

    Broader source: Energy.gov [DOE]

    The DOE's Biological Safety Program provides a forum for the exchange of best practices, lessons learned, and guidance in the area of biological safety. This content is supported by the Biosurety Executive Team. The Biosurety Executive Team is a DOE-chartered group. The DOE Office of Worker Safety and Health Policy provides administrative support for this group. The group identifies biological safety-related issues of concern to the DOE and pursues solutions to issues identified.

  7. BE.462J Molecular Principles of Biomaterials, Spring 2003

    E-Print Network [OSTI]

    Irvine, Darrell J.

    Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules ...

  8. Molecular Cell Structure and Biological Importance

    E-Print Network [OSTI]

    Hill, Chris

    ,* and Christopher P. Hill1,* 1Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT- dues 140­300) that is flanked on both sides by regions that are predicted to be disordered (Ward et al that is expected to be unstructured (Ward et al., 2004) and a C-terminal domain (CTD) that adopts an SH2 fold

  9. A unified model of electroporation and molecular transport

    E-Print Network [OSTI]

    Smith, Kyle Christopher

    2011-01-01

    Biological membranes form transient, conductive pores in response to elevated transmembrane voltage, a phenomenon termed electroporation. These pores facilitate electrical and molecular transport across cell membranes that ...

  10. Offered Fall Semester: Biological Physics

    E-Print Network [OSTI]

    Collins, Gary S.

    Offered Fall Semester: Biological Physics Physics 466 / Physics 566 (conjoint) provides a fundamental physical understanding of the operation of cells, biomolecules and molecular machines. MWF 4:10-5:00pm, Webster 11 (3 cr) Instructor: Fred Gittes, Clinical Professor of Physics and Astronomy: gittes

  11. Ninth International Workshop on Plant Membrane Biology

    SciTech Connect (OSTI)

    Not Available

    1993-12-31

    This report is a compilation of abstracts from papers which were discussed at a workshop on plant membrane biology. Topics include: plasma membrane ATP-ases; plant-environment interactions, membrane receptors; signal transduction; ion channel physiology; biophysics and molecular biology; vaculor H+ pumps; sugar carriers; membrane transport; and cellular structure and function.

  12. National Laboratory] Basic Biological Sciences(59) Biological...

    Office of Scientific and Technical Information (OSTI)

    Achievements of structural genomics Terwilliger, Thomas C. Los Alamos National Laboratory Basic Biological Sciences(59) Biological Science Biological Science Abstract Not...

  13. Quantum physics meets biology

    E-Print Network [OSTI]

    Markus Arndt; Thomas Juffmann; Vlatko Vedral

    2009-11-01

    Quantum physics and biology have long been regarded as unrelated disciplines, describing nature at the inanimate microlevel on the one hand and living species on the other hand. Over the last decades the life sciences have succeeded in providing ever more and refined explanations of macroscopic phenomena that were based on an improved understanding of molecular structures and mechanisms. Simultaneously, quantum physics, originally rooted in a world view of quantum coherences, entanglement and other non-classical effects, has been heading towards systems of increasing complexity. The present perspective article shall serve as a pedestrian guide to the growing interconnections between the two fields. We recapitulate the generic and sometimes unintuitive characteristics of quantum physics and point to a number of applications in the life sciences. We discuss our criteria for a future quantum biology, its current status, recent experimental progress and also the restrictions that nature imposes on bold extrapolations of quantum theory to macroscopic phenomena.

  14. The BioASP Library: ASP Solutions for Systems Biology

    E-Print Network [OSTI]

    Schaub, Torsten

    The BioASP Library: ASP Solutions for Systems Biology Martin Gebser, Arne K¨onig, Torsten Schaub--Today's molecular biology is confronted with enor- mous amounts of data, generated by new high-throughput tech- nologies, along with an increasing number of biological models available over web repositories. This poses

  15. Biological preconcentrator

    DOE Patents [OSTI]

    Manginell, Ronald P. (Albuquerque, NM); Bunker, Bruce C. (Albuquerque, NM); Huber, Dale L. (Albuquerque, NM)

    2008-09-09

    A biological preconcentrator comprises a stimulus-responsive active film on a stimulus-producing microfabricated platform. The active film can comprise a thermally switchable polymer film that can be used to selectively absorb and desorb proteins from a protein mixture. The biological microfabricated platform can comprise a thin membrane suspended on a substrate with an integral resistive heater and/or thermoelectric cooler for thermal switching of the active polymer film disposed on the membrane. The active polymer film can comprise hydrogel-like polymers, such as poly(ethylene oxide) or poly(n-isopropylacrylamide), that are tethered to the membrane. The biological preconcentrator can be fabricated with semiconductor materials and technologies.

  16. Biomimetics Engineering from Biology

    E-Print Network [OSTI]

    Agogino, Alice M.

    Biomimetics or Engineering from Biology Hari Dharan Department of Mechanical Engineering University" ­ copying only? !!"Biologically-Inspired Design" !!"Engineering from Biology" Definition !!It is not "biology for engineers". !!It is not "imitating" or "copying" biology. !!It is not "reverse

  17. Modern concepts in molecular modeling

    SciTech Connect (OSTI)

    Bajorath, J.; Klein, T.E.

    1996-12-31

    This session focused on the application of computer models and the development and application of various energy functions to study the structure, energetics and dynamics of proteins and their interactions with ligands. These studies provide an exciting view of current developments in computer-aided molecular modeling and theoretical analysis of biological molecules.

  18. Systems biology approach to bioremediation

    SciTech Connect (OSTI)

    Chakraborty, R.; Wu, C. H.; Hazen, T. C.

    2012-01-01

    Bioremediation has historically been approached as a ?black box? in terms of our fundamental understanding. Thus it succeeds and fails, seldom without a complete understanding of why. Systems biology is an integrated research approach to study complex biological systems, by investigating interactions and networks at the molecular, cellular, community, and ecosystem level. The knowledge of these interactions within individual components is fundamental to understanding the dynamics of the ecosystem under investigation. Understanding and modeling functional microbial community structure and stress responses in environments at all levels have tremendous implications for our fundamental understanding of hydrobiogeochemical processes and the potential for making bioremediation breakthroughs and illuminating the ?black box?.

  19. This article is available online at http://www.jlr.org Journal of Lipid Research Volume 54, 2013 3215 Copyright 2013 by the American Society for Biochemistry and Molecular Biology, Inc.

    E-Print Network [OSTI]

    Hammock, Bruce D.

    that the 20-HETE pathway contrib- utes to the cardiovascular risks of COX inhibitors (9). More studies method to prepare 20-HETE would greatly facilitate the evaluation of its biological ac- tivities

  20. Molecular Foundry

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Flatter and Faster: Transition Metal Dichalcogendies at the Molecular Foundry (Part II) Brain Imaging and Optical Manipulation Active Nanointerfaces for Electrochemistry SAXS-WAXS...

  1. Molecular Biomechanics: The Molecular Basis of How Forces Regulate Cellular Function

    E-Print Network [OSTI]

    Bao, Gang

    Recent advances have led to the emergence of molecular biomechanics as an essential element of modern biology. These efforts focus on theoretical and experimental studies of the mechanics of proteins and nucleic acids, and ...

  2. DEPARTMENT OF BIOLOGY AND MARINE BIOLOGY

    E-Print Network [OSTI]

    Olszewski Jr., Edward A.

    DEPARTMENT OF BIOLOGY AND MARINE BIOLOGY GRADUATE PROGRAM REVIEW 2000-2007 #12;i TABLE OF CONTENTS ....................................................................... 389 #12;ii EXECUTIVE SUMMARY The Department of Biology and Marine Biology contributes importantly). The department began offering the Master of Science in Marine Biology in 1980, and the Master of Science

  3. Biology reflective assessment curriculum

    E-Print Network [OSTI]

    Bayley, Cheryl Ann

    2011-01-01

    Penick, J. E. (1998). Biology: A community context. Newof a standards-based high school biology curriculum.The American Biology Teacher Li, J. , Klahr, D. , & Siler,

  4. 60 Volume 81THE QUARTERLY REVIEW OF BIOLOGY orchestrate the dynamics of force production, di-

    E-Print Network [OSTI]

    Rieseberg, Loren

    ­471­45329­3. 2005. GENETICS & EVOLUTION Endless Forms Most Beautiful: The New Sci- ence of Evo Devo and the Making- veloping science of "evo devo" consists of, and why this is one of the most exciting areas of biology today. Evo devo is a fusion of genetics, molecular biology, developmental biology, and evolutionary biology

  5. BIOL 206-Introduction to Organismal Biology-Spring 2013 Alejandro Acevedo-Gutirrez

    E-Print Network [OSTI]

    Acevedo, Alejandro

    . 2010. Life: The Science of Biology. Vol. III. 9th edn. Freeman, W. H. & Co. ISBN: 9781429254281. [10th, K. 2009. A Student Handbook for Writing in Biology. 3rd edn. Sinauer Associates. [1st or 2nd and apply fundamental biological principles of ecology, genetics, evolution, cell and molecular biology

  6. Nonlinear Elasticity in Biological Gels

    E-Print Network [OSTI]

    Cornelis Storm; Jennifer J. Pastore; Fred C. MacKintosh; Tom C. Lubensky; Paul A. Janmey

    2004-06-01

    Unlike most synthetic materials, biological materials often stiffen as they are deformed. This nonlinear elastic response, critical for the physiological function of some tissues, has been documented since at least the 19th century, but the molecular structure and the design principles responsible for it are unknown. Current models for this response require geometrically complex ordered structures unique to each material. In this Article we show that a much simpler molecular theory accounts for strain stiffening in a wide range of molecularly distinct biopolymer gels formed from purified cytoskeletal and extracellular proteins. This theory shows that systems of semi-flexible chains such as filamentous proteins arranged in an open crosslinked meshwork invariably stiffen at low strains without the need for a specific architecture or multiple elements with different intrinsic stiffnesses.

  7. Published on Science 2.0 (http://www.science20.com) Home > Life Sciences > Genetics & Molecular Biology > News Articles > Rad51: Watching Single Strands Of DNA Being Prepped For Repair Could Help Fight Breast Cancer

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    Biology > News Articles > Rad51: Watching Single Strands Of DNA Being Prepped For Repair Could Help Fight Breast Cancer Rad51: Watching Single Strands Of DNA Being Prepped For Repair Could Help Fight Breast: Watching Single Strands Of DNA Being Prepped For Repair Could Help Fight Br... 6/17/2013http

  8. Theory in Biology Computational

    E-Print Network [OSTI]

    Goldbeter, Albert

    Magazine R601 Theory in Biology Computational biology: A propagating wave of interest Albert Goldbeter Systems biology, computational biology, integrative biology... many names are being used and tendency to take a global view of problems in biology. This field is not entirely novel, but what is clear

  9. Einar M. Sigurdsson et al. (eds.), Amyloid Proteins: Methods and Protocols, Methods in Molecular Biology, vol. 849, DOI 10.1007/978-1-61779-551-0_6, Springer Science+Business Media, LLC 2012

    E-Print Network [OSTI]

    Benedek, George B.

    69 Einar M. Sigurdsson et al. (eds.), Amyloid Proteins: Methods and Protocols, Methods in Molecular Quasielastic Light Scattering Study of Amyloid b-Protein Fibrillogenesis Aleksey Lomakin and David B. Teplow provides a powerful tool for studying protein assembly. We illustrate here how QLS has been applied

  10. Biology 3515/Chemistry 3515 Biological Chemistry Laboratory

    E-Print Network [OSTI]

    Simons, Jack

    Biology 3515/Chemistry 3515 Biological Chemistry Laboratory Spring 2013 (Draft Syllabus, 23 August 2012) Course Description and Objectives: This course is intended for students who have taken Biology and function, particularly for enzymes. Prerequisites: Biology 3510 or Chemistry 3510 Instructor: David P

  11. Micro/nanofabricated environments for synthetic biology

    SciTech Connect (OSTI)

    Collier, Pat [ORNL; Simpson, Michael L [ORNL

    2011-01-01

    A better understanding of how confinement, crowding and reduced dimensionality modulate reactivity and reaction dynamics will aid in the rational and systematic discovery of functionality in complex biological systems. Artificial micro- and nanofabricated structures have helped elucidate the effects of nanoscale spatial confinement and segregation on biological behavior, particularly when integrated with microfluidics, through precise control in both space and time of diffusible signals and binding interactions. Examples of nanostructured interfaces for synthetic biology include the development of cell-like compartments for encapsulating biochemical reactions, nanostructured environments for fundamental studies of diffusion, molecular transport and biochemical reaction kinetics, and regulation of biomolecular interactions as functions of micro- and nanofabricated topological constraints.

  12. Molecular fountain.

    SciTech Connect (OSTI)

    Strecker, Kevin E.; Chandler, David W.

    2009-09-01

    A molecular fountain directs slowly moving molecules against gravity to further slow them to translational energies that they can be trapped and studied. If the molecules are initially slow enough they will return some time later to the position from which they were launched. Because this round trip time can be on the order of a second a single molecule can be observed for times sufficient to perform Hz level spectroscopy. The goal of this LDRD proposal was to construct a novel Molecular Fountain apparatus capable of producing dilute samples of molecules at near zero temperatures in well-defined user-selectable, quantum states. The slowly moving molecules used in this research are produced by the previously developed Kinematic Cooling technique, which uses a crossed atomic and molecular beam apparatus to generate single rotational level molecular samples moving slowly in the laboratory reference frame. The Kinematic Cooling technique produces cold molecules from a supersonic molecular beam via single collisions with a supersonic atomic beam. A single collision of an atom with a molecule occurring at the correct energy and relative velocity can cause a small fraction of the molecules to move very slowly vertically against gravity in the laboratory. These slowly moving molecules are captured by an electrostatic hexapole guiding field that both orients and focuses the molecules. The molecules are focused into the ionization region of a time-of-flight mass spectrometer and are ionized by laser radiation. The new molecular fountain apparatus was built utilizing a new design for molecular beam apparatus that has allowed us to miniaturize the apparatus. This new design minimizes the volumes and surface area of the machine allowing smaller pumps to maintain the necessary background pressures needed for these experiments.

  13. CEL October 2006 Cell biology overview

    E-Print Network [OSTI]

    -electron therapy Multi-purpose projects · Cell nursing in 2D and 3D · Optical nanosensors Tools · Molecular biology be coupled to immobilized avidin In mold patterning of avidin makes it possible to structure the surface immune response to transplanted organs Aim Effects Materials Methods To discover antibodies in blood

  14. Physics Meets Biology (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Chu, Steve [Director, LBNL

    2011-04-28

    Summer Lecture Series 2006: If scientists could take advantage of the awesomely complex and beautiful functioning of biologys natural molecular machines, their potential for application in many disciplines would be incalculable. Nobel Laureate and Director of the Lawrence Berkeley National Laboratory Steve Chu explores Possible solutions to global warming and its consequences.

  15. Biological Frameworks for Engineers ME 411 / ME511

    E-Print Network [OSTI]

    Sniadecki, Nathan J.

    nd Edition, Garland Press, ISBN: 0815332823 3) Alberts et al. Molecular Biology of the Cell, Garland://courses.washington.edu/nsniadec/ME411/A12 Course Description: Introduction to the fundamentals of biology for an engineer. Mechanisms to Biomechanics: From Cells to Organisms, Cambridge University Press, ISBN: 0521841127 2) Bray, Cell Movements, 2

  16. Biological Frameworks for Engineers ME 411 / ME511

    E-Print Network [OSTI]

    Sniadecki, Nathan J.

    Movements, 2nd Edition, Garland Press, ISBN: 0815332823 2) Alberts et al. Molecular Biology of the Cell, 4thnd Edition. Garland Science, ISBN: 0815344503. 2) Ethier and Simmons, Introduction to Biomechanics: Introduction to the fundamentals of biology for an engineer. Mechanisms and biomechanics of DNA, proteins

  17. Splicing bioinformatics to biology

    E-Print Network [OSTI]

    Black, Douglas L; Graveley, Brenton R

    2006-01-01

    Splicing bioinformatics to biology Douglas L Black* andand Developmental Biology, University of Connecticut Health26 May 2006 Genome Biology 2006, 7:317 (doi:10.1186/gb-2006-

  18. Continuum Electrostatics in Cell Biology

    E-Print Network [OSTI]

    L. John Gagliardi

    2010-02-06

    Recent experiments revealing possible nanoscale electrostatic interactions in force generation at kinetochores for chromosome motions have prompted speculation regarding possible models for interactions between positively charged molecules in kinetochores and negative charge on C-termini near the plus ends of microtubules. A clear picture of how kinetochores establish and maintain a dynamic coupling to microtubules for force generation during the complex motions of mitosis remains elusive. The current paradigm of molecular cell biology requires that specific molecules, or molecular geometries, for force generation be identified. However, it is possible to account for mitotic motions within a classical electrostatics approach in terms of experimentally known cellular electric charge interacting over nanometer distances. These charges are modeled as bound surface and volume continuum charge distributions. Electrostatic consequences of intracellular pH changes during mitosis may provide a master clock for the events of mitosis.

  19. Optimization of parameters for coverage of low molecular weight proteins

    E-Print Network [OSTI]

    Muller, Stephan A.

    Proteins with molecular weights of <25 kDa are involved in major biological processes such as ribosome formation, stress adaption (e.g., temperature reduction) and cell cycle control. Despite their importance, the coverage ...

  20. HST.176 Cellular and Molecular Immunology, Fall 2002

    E-Print Network [OSTI]

    Pillai, Shiv

    Covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation including molecular structure and assembly of ...

  1. Dissecting the Molecular Basis of the Mechanics of Living Cells

    E-Print Network [OSTI]

    Kumar, Sanjay

    the past two decades, an exciting suite of sophisticated micro- and nanoscale technologies has emerged: atomic force microscopy, subcellular laser ablation, micropatterning, and microfluidics. Together biology. Keywords Cellular. Molecular. Structure . Mechanics . Atomic force microscopy. Laser

  2. Microfluidics for quantitative biology

    E-Print Network [OSTI]

    Adler, Micha

    2012-01-01

    CALIFORNIA, SAN DIEGO Microfluidics for Quantitative BiologyChapter 1: Microfluidics.………………………………………………………..… 1 1.1OF THE DISSERTATION Microfluidics for Quantitative Biology

  3. [Studies of biologic activation associated with molecular receptor increase and tumor response in ChL6/L6 protocol patients; Studies in phantoms; Quantitative SPECT; Preclinical studies; and Clinical studies]. DOE annual report, 1994--95

    SciTech Connect (OSTI)

    DeNardo, S.J.

    1995-12-31

    The authors describe results which have not yet been published from their associated studies listed in the title. For the first, they discuss Lym-1 single chain genetically engineered molecules, analysis of molecular genetic coded messages to enhance tumor response, and human dosimetry and therapeutic human use radiopharmaceuticals. Studies in phantoms includes a discussion of planar image quantitation, counts coincidence correction, organ studies, tumor studies, and {sup 90}Y quantitation with Bremsstrahlung imaging. The study on SPECT discusses attenuation correction and scatter correction. Preclinical studies investigated uptake of {sup 90}Y-BrE-3 in mice using autoradiography. Clinical studies discuss image quantitation verses counts from biopsy samples, S factors for radiation dose calculation, {sup 67}Cu imaging studies for lymphoma cancer, and {sup 111}In MoAb imaging studies for breast cancer to predict {sup 90}Y MoAb therapy.

  4. computational modeling of biological systems

    E-Print Network [OSTI]

    $author.value

    Faculty. Faculty listing for "computational modeling of biological systems" ... Research Interests: computational modeling of biological systems.

  5. Thermodynamics of site-specific small molecular ion interactions with DNA duplex: a molecular dynamics study

    E-Print Network [OSTI]

    Ghosh, Soumadwip; Chakrabarti, Rajarshi

    2015-01-01

    The stability and dynamics of a double-stranded DNA (dsDNA) is affected by the preferential occupancy of small monovalent molecular ions. Small metal and molecular ions such as sodium and alkyl ammonium have crucial biological functions in human body, affect the thermodynamic stability of the duplex DNA and exhibit preferential binding. Here, using atomistic molecular dynamics simulations we investigate the preferential binding of metal ion such as Na+ and molecular ions such as tetramethyl ammonium (TMA+) and 2-hydroxy-N,N,N-trimethylethanaminium (CHO+) to double stranded DNA. The thermodynamic driving force for a particular molecular ion- DNA interaction is determined by decomposing the free energy of binding into its entropic and enthalpic contributions. Our simulations show that each of these molecular ions preferentially binds to the minor groove of the DNA and the extent of binding is highest for CHO+. The ion binding processes are found to be entropically favourable. In addition, the contribution of hy...

  6. In this Issue CeBiTec Symposium: Molecular Biotechnology

    E-Print Network [OSTI]

    Moeller, Ralf

    of tools and techniques for transcriptome sequencing 3rd CeBiTec Students Academy Synthetic Biology and Bielefeld presented insights into cutting edge developments of Molecular Biotechnology. This regional focus compounds to biological halogenation, enzyme coatings and chemical protein labelling. One session

  7. 20.462J / 3.962J Molecular Principles of Biomaterials (BE.462J), Spring 2003

    E-Print Network [OSTI]

    Irvine, Darrell J.

    Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules ...

  8. Molecular Dynameomics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJessework uses concrete7Modifications for Public CommentDynameomics Molecular

  9. Biology and Medicine Division: Annual report 1986

    SciTech Connect (OSTI)

    Not Available

    1987-04-01

    The Biology and Medicine Division continues to make important contributions in scientific areas in which it has a long-established leadership role. For 50 years the Division has pioneered in the application of radioisotopes and charged particles to biology and medicine. There is a growing emphasis on cellular and molecular applications in the work of all the Division's research groups. The powerful tools of genetic engineering, the use of recombinant products, the analytical application of DNA probes, and the use of restriction fragment length polymorphic DNA are described and proposed for increasing use in the future.

  10. Institute for Molecular Medicine Research Program

    SciTech Connect (OSTI)

    Phelps, Michael E

    2012-12-14

    The objectives of the project are the development of new Positron Emission Tomography (PET) imaging instrumentation, chemistry technology platforms and new molecular imaging probes to examine the transformations from normal cellular and biological processes to those of disease in pre-clinical animal models. These technology platforms and imaging probes provide the means to: 1. Study the biology of disease using pre-clinical mouse models and cells. 2. Develop molecular imaging probes for imaging assays of proteins in pre-clinical models. 3. Develop imaging assays in pre-clinical models to provide to other scientists the means to guide and improve the processes for discovering new drugs. 4. Develop imaging assays in pre-clinical models for others to use in judging the impact of drugs on the biology of disease.

  11. Mathematical Biology 3 Jurgen Jost

    E-Print Network [OSTI]

    Arnold, Anton

    Mathematical Biology 3 J¨urgen Jost Max Planck Institute for Mathematics in the Sciences Leipzig, Germany Mathematical Biology 3 ­ p. 1 #12;Biological networks In biology, we find many examples of interacting elements: Mathematical Biology 3 ­ p. 2 #12;Biological networks In biology, we find many examples

  12. 2003 Synthetic Biology study

    E-Print Network [OSTI]

    Endy, Drew

    2007-08-14

    Biology is a technology for processing information, materials, and energy. As a technology platform, biological systems provide access to artifacts and processes across a range of scales (e.g., the ribosome is a programmable ...

  13. Commercial Fisheries Biological Laboratory

    E-Print Network [OSTI]

    Bureau of Commercial Fisheries Biological Laboratory Oxford, Maryland #12;Chart of the Tred Avon River, showing the location of the BCF Biological Laboratory and the orientation of this area modern laboratories for chem- ical, histological, microbiological, and physiological re- search

  14. Chemistry & Biology Brief Communication

    E-Print Network [OSTI]

    Zhao, Huimin

    Chemistry & Biology Brief Communication Cloning, IL 61801, USA 3Department of Chemistry 4Department of Chemical and Biomolecular Engineering

  15. A Central Theory of Biology

    E-Print Network [OSTI]

    Torday, JS

    2015-01-01

    JS, Rehan VK. Evolutionary biology, cell–cell communication6] Torday JS. Evolutionary Biology Redux. Pers Biol Med 56,explanations in evolutionary biology. Hist Philos Life Sci

  16. Systems biology approach to bioremediation

    E-Print Network [OSTI]

    Chakraborty, R.

    2013-01-01

    aspects of the systems biology approach (metagenomics withthe use of a number of sytems biology parameters can revealRL, Banfield JF: Systems Biology: functional analysis of

  17. Todd Newberry: Professor of Biology

    E-Print Network [OSTI]

    Newberry, Andrew Todd; Jarrell, Randall; Regional History Project, UCSC Library

    2006-01-01

    Todd Newberry, Professor of Biology: Cowell College page 12Jarrell: Why’s that? Todd Newberry, Professor of Biology:Biology Board page 14 Newberry: Well, besides the

  18. HARVARD UNIVERSITY CHEMICAL BIOLOGY

    E-Print Network [OSTI]

    Church, George M.

    HARVARD UNIVERSITY CHEMICAL BIOLOGY PHD PROGRAM 2013-2014 Student Handbook #12;Program Contacts at the beginning of each semester. Laboratory Rotations Students in the Chemical Biology Program are expected an interest in having Chemical Biology Program Students in their labs. Students may rotate in the labs

  19. The Intersection of Physics and Biology

    ScienceCinema (OSTI)

    Liphardt, Jan [University of California, Berkeley, California, United States

    2010-09-01

    In April 1953, Watson and Crick largely defined the program of 20th century biology: obtaining the blueprint of life encoded in the DNA. Fifty years later, in 2003, the sequencing of the human genome was completed. Like any major scientific breakthrough, the sequencing of the human genome raised many more questions than it answered. I'll brief you on some of the big open problems in cell and developmental biology, and I'll explain why approaches, tools, and ideas from the physical sciences are currently reshaping biological research. Super-resolution light microscopies are revealing the intricate spatial organization of cells, single-molecule methods show how molecular machines function, and new probes are clarifying the role of mechanical forces in cell and tissue function. At the same time, Physics stands to gain beautiful new problems in soft condensed matter, quantum mechanics, and non-equilibrium thermodynamics.

  20. Minor in Marine Biology Minor in Marine Biology

    E-Print Network [OSTI]

    Chen, Tsuhan

    Minor in Marine Biology Minor in Marine Biology General Goals of the Minor in Marine Biology About who choose the Minor in Marine Biology will learn about the biology, evolution and ecology of organisms that inhabit these environments and the ecological processes linking them. Marine biology draws

  1. Invasion Biology Mark A. Davis

    E-Print Network [OSTI]

    Davis, Mark A.

    Invasion Biology Mark A. Davis 2 biology 2 MarkA.DavisInvasionBiology2 1 With the exception of climate change, biological invasions have probably received more attention during the past ten years than on the subject, Invasion Biology provides a comprehensive and up-to-date review of the science of biological

  2. BiochEMiStry AnD MolEculAr College of Natural Science and Mathematics

    E-Print Network [OSTI]

    Hartman, Chris

    BiochEMiStry AnD MolEculAr Biology College of Natural Science and Mathematics Department of Chemistry and Biochemistry 907-474-5510 www.uaf.edu/chem/ MS, phD Degrees Minimum Requirements for Degrees: MS: 30 credits; PhD: 18 thesis credits Biochemistry and molecular biology is an interdepartmental

  3. Engineering optical traps for new environments and applications in the measurement of biological adhesives and motors

    E-Print Network [OSTI]

    Appleyard, David Collins

    2009-01-01

    Optical traps have played a central role in the exploration of biological systems through the examination of molecular motors, biopolymers, and many other interactions at the nano and micro length scales. This thesis seeks ...

  4. Biological detector and method

    DOE Patents [OSTI]

    Sillerud, Laurel; Alam, Todd M; McDowell, Andrew F

    2014-04-15

    A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

  5. Biological detector and method

    DOE Patents [OSTI]

    Sillerud, Laurel; Alam, Todd M; McDowell, Andrew F

    2013-02-26

    A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

  6. Biology | More Science | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Atmospheric Sciences Materials Science and Engineering Mathematics Physics Environment Safety and Health More Science Home | Science & Discovery | More Science | Biology SHARE...

  7. Genomics and Systems Biology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Genomics and Systems Biology LANL leads the world in computational finishing of microbial genomes Read caption + In 2013, Los Alamos scientist Richard Sayre and his team...

  8. Suzanne Barbour Department of Biochemistry and Molecular Biology

    E-Print Network [OSTI]

    Hammack, Richard

    and Disability Policy School readiness of high-risk youth: A longitudinal follow-up of early risk and resilience of labor market assignment Virginia Commonwealth University Presidential Research Incentive Program

  9. Biochemistry 218 -BioMedical Informatics 231 Computational Molecular Biology

    E-Print Network [OSTI]

    ., 2003; Wouters et al., 2003; Yeung et al., 2004; Saidi et al., 2004; Girolami and Breitling, 2004), Saidi et al., 2004, Tham et al. (2003), Girolami and Breitling (2004), and Hubert and Engelen (2004

  10. Molecular Biology of the Cell Vol. 15, 30053014, July 2004

    E-Print Network [OSTI]

    Newman, Eric A.

    Is Dispensable for Essential Cytoplasmic Dynein Functions but Is Required during Spermatid DifferentiationD Min-end­directed microtubule motor cytoplasmic dynein has been implicated in a variety of cellular processes, including nuclear more than one cytoplasmic dynein heavy chain has been identified, the major cytoplasmic dynein motor

  11. Formal Molecular Biology done in CCSR Vincent Danos

    E-Print Network [OSTI]

    Danos, Vincent - Laboratoire Preuves, Programmes et Systčmes, Université Paris 7

    should the dense networks of interacting processes the cell is made of be described, simulated and analyzed ? The bulk of the reconstruction e#ort for now is aiming at genetic regula­ tion networks unnoticed, and many di#erent languages have already been proposed: plain di#erential systems [3], Petri Nets

  12. Molecular Biology of the Cell Vol. 15, 12541261, March 2004

    E-Print Network [OSTI]

    Botstein, David

    to heat stress in mammalian cells. We characterized the heat shock response of mammalian cells are unable to induce expression of hsp70 in re- sponse to heat stress (McMillan et al., 1998), whereas HSF2 processes in addition to the response to heat stress (Xiao et al., 1999). The heat shock response is highly

  13. Plant Molecular Biology Reporter Volume 11(1) 1993

    E-Print Network [OSTI]

    Rieseberg, Loren

    ,thusenhanc ingpatientandfamilysatisfactionandreducingthelevelofanxietyandfearwhichtheymaybeexperiencing. Efficientlymovingthepatienttotheirinpatientproviders'resultsinopenEDexamrooms.Thisshortensthe

  14. Computational Molecular Biology Biochem 218 BioMedical Informatics 231

    E-Print Network [OSTI]

    evolution? Which nodes are orthologous and which are paralogous bifurcations? · Do the trees show evidence vs. Colicin #12;· Protein DataBase o Multiple Structure Viewers o Sequence & Structure Comparison and Entire Database PDB Protein Database http://www.rcsb.org/pdb/ #12;PDB Protein Database http

  15. Computational Molecular Biology Biochem 218 BioMedical Informatics 231

    E-Print Network [OSTI]

    .edu/ Doug Brutlag Professor Emeritus Biochemistry & Medicine (by courtesy) The Human Genome Project #12 Gibson & Muse, A Primer of Genome Science http://www.sinauer.com/genomics/ #12;The Human Genome Project?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3294162 #12;Public Genome Assembly Process #12;BAC and PAC Libraries in Public Human Genome Project http

  16. Molecular Biology of the Cell Vol. 21, 39553966, November 2002

    E-Print Network [OSTI]

    Shorter, James

    are essential for the maintenance of cellular ion homeostasis. In the secretory pathway, the P-type ATPase to strains lacking Pmr1p, a Ca2 /Mn2 pump that resides in the medial-Golgi. Because of its localization

  17. UNIVERSITY OF CALIFORNIA, SANTA CRUZ MOLECULAR, CELL, & DEVELOPMENTAL BIOLOGY

    E-Print Network [OSTI]

    California at Santa Cruz, University of

    is for one year. Should the hiring unit propose reappointment, a review to assess performance: Review of applications will begin on February 27, 2015. To ensure full consideration, applications should, disability, age, or protected veteran status. UC Santa Cruz is committed to excellence through diversity

  18. UNIVERSITY OF CALIFORNIA, SANTA CRUZ MOLECULAR, CELL, AND DEVELOPMENTAL BIOLOGY

    E-Print Network [OSTI]

    California at Santa Cruz, University of

    . Should the hiring unit propose reappointment, a review to assess performance will be conducted statement at http://apo.ucsc.edu/confstm.htm. CLOSING DATE: Review of applications will begin on June 29, national origin, disability, age, or protected veteran status. UC Santa Cruz is committed to excellence

  19. Molecular Biology of the Cell Vol. 18, 14101420, April 2007

    E-Print Network [OSTI]

    Steinberg, Stanly

    , and Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM 87131 Submitted November 23, migration, and degran- ulation. Here, immunogold labeling is used to map the plasma membrane distributions

  20. Molecular Biology of the Cell Vol. 14, 14681478, April 2003

    E-Print Network [OSTI]

    Goldman, Robert D.

    -dependent Disassembly of Vimentin Intermediate Filaments During Mitosis Ying-Hao Chou*, Satya Khuon*, Harald Herrmann Monitoring Editor: Paul T. Matsudaira The expression of the intermediate filament (IF) protein nestin (Chou et al., 1996). For example, in mitotic BHK-21 cells, the interphase IF network, which is composed

  1. Molecular Biology of the Cell Vol. 14, 26652676, July 2003

    E-Print Network [OSTI]

    infused laminin-1 ( 1, 1, 1) into the mouse hippocampus. This infusion specifically disrupted chain with endogenous laminin-10, because infusion of anti-laminin 1 antibody had the same effect. The disruption of the laminin layer by laminin-1 1) did not require the intact protein because infusion

  2. C H A P T E R Molecular Biology for

    E-Print Network [OSTI]

    Borenstein, Elhanan

    what mathematics is to physics." -- Harold Morowitz One of the major challenges for computer scientists, it is often necessary to use concepts involving, for example, cells, embryological development, or evolution to differ from each other, and to reach modern levels of complexity through evolution. Evolution has three

  3. Integrating molecular and network biology to decode endocytosis

    E-Print Network [OSTI]

    McMahon, Harvey

    design principles and of spatio-temporal dynamics behind pathways, and aids in experimental design and intermediate stages of vesicle formation have been docu- mented (Fig. 1a)3 . An extensive protein machinery in the literature16 ). To emphasize the core machinery of endocytosis we peeled away inter- actions that point

  4. Molecular pharmacology of an insect GABA receptor

    E-Print Network [OSTI]

    McGonigle, Ian Vincent

    2010-10-12

    and guided by Andy Thompson. Andy is an exceptional scientist and his electrophys expertise, his good company and his enthusiasm have made my PhD a truly enjoyable experience; thanks Andy. In moments of molecular biology crisis Kerry Price has always been... mention and thanks. They were always there to answer my questions about practical things and their knowledge and experience were greatly valued. The many students and visitors who have passed through ‘Skylab’ have enhanced the experience of my Ph...

  5. Intelligent systems for the molecular biologist

    SciTech Connect (OSTI)

    Brutlag, D.L.

    1995-12-31

    This tutorial was one of eight tutorials selected to be presented at the Third International Conference on Intelligent Systems for Molecular Biology which was held in the United Kingdom from July 16 to 19, 1995. In this paper, one objective is to identify properties of DNA sequences that determine their function, by computer-aided statistical analysis and to accurately predict its function, given a new sequence. A related problem is to predict protein structure and function from the sequence.

  6. BACHELOR OF SCIENCE BIOLOGY ECOLOGY & EVOLUTIONARY BIOLOGY OPTION

    E-Print Network [OSTI]

    Kemp, Brian M.

    BACHELOR OF SCIENCE ­ BIOLOGY ECOLOGY & EVOLUTIONARY BIOLOGY OPTION A Bachelor of Science degree hours must be upper division coursework. A B.S. in Biology requires a minimum of 19 semester hours of core BIOLOGY courses (BIOLOGY 106, 107, 301, 372 and 405 or 403). An additional 21 semester hours

  7. Biology and Marine Biology Research Areas and Assistantship Application

    E-Print Network [OSTI]

    Olszewski Jr., Edward A.

    1 Biology and Marine Biology Research Areas and Assistantship Application Name: LAST FIRST MIDDLE and Marine Biology faculty members will accept graduate students to work in the general research areas listed Next Page Revised 3/08 850 #12;2 Biology and Marine Biology Statement of Interest Statement of Interest

  8. Integrated Biological Control

    SciTech Connect (OSTI)

    JOHNSON, A.R.

    2003-10-09

    Biological control is any activity taken to prevent, limit, clean up, or remediate potential environmental, health and safety, or workplace quality impacts from plants, animals, or microorganisms. At Hanford the principal emphasis of biological control is to prevent the transport of radioactive contamination by biological vectors (plants, animals, or microorganisms), and where necessary, control and clean up resulting contamination. Other aspects of biological control at Hanford include industrial weed control (e.g.; tumbleweeds), noxious weed control (invasive, non-native plant species), and pest control (undesirable animals such as rodents and stinging insects, and microorganisms such as molds that adversely affect the quality of the workplace environment). Biological control activities may be either preventive (a priori) or in response to existing contamination spread (a posteriori). Surveillance activities, including ground, vegetation, flying insect, and other surveys, and a priori control actions, such as herbicide spraying and placing biological barriers, are important in preventing radioactive contamination spread. If surveillance discovers that biological vectors have spread radioactive contamination, a posteriori control measures, such as fixing contamination, followed by cleanup and removal of the contamination to an approved disposal location are typical response functions. In some cases remediation following the contamination cleanup and removal is necessary. Biological control activities for industrial weeds, noxious weeds and pests have similar modes of prevention and response.

  9. Journal of Bioinformatics and Computational Biology Imperial College Press

    E-Print Network [OSTI]

    Vucetic, Slobodan

    focus on improving sequence-based predictions of long (> 30 amino acid residues) regions lacking the molecular biology community1-6 . Disorder refers to the structural property that the amino acid sequence unfolded or disordered region. Disordered regions longer than 30 consecutive amino acids are considered

  10. Biomimetic Mineralization: Mesoporous Biological mineral synthesis, in contrast to conven-

    E-Print Network [OSTI]

    Biomimetic Mineralization: Mesoporous Structures Biological mineral synthesis, in contrast of mineral crystals. Mesophases are materials which have domain length scales of the order of a few as a molecular blueprint for the site- directed formation of the inorganic phase, by providing an interface

  11. Evolutionary developmental biology (evodevo) emerged as a distinct field of

    E-Print Network [OSTI]

    Müller, Gerd B.

    Evolutionary developmental biology (evo­devo) emerged as a distinct field of research in the early of developmental processes of different taxa at the molecular level. Today, evo­devo research is characterized two decades, at least four major research programmes have formed in evo­devo, although

  12. ePUB: Modellierung Molecular Life Sciences Master Major 90 ECTS-Credits with special qualification in Biochemistry/

    E-Print Network [OSTI]

    Richner, Heinz

    in Biochemistry/ Chemical Biology [Reglement 01.10.2005] Seite 1 1. Teil: Struktur des Studiums (Prüfungsfächer) Offizieller Abschluss: Master of Science in Molecular Life Sciences with special qualification in Biochemistry/Chemical Biology, Universität Bern ePUB - interne Bezeichnung: MLS M Major 90 ECTS Biochemistry/Chemical Biology

  13. Science Faculty Department of Biology

    E-Print Network [OSTI]

    Richner, Heinz

    Science Faculty Department of Biology Zoological Institute Community Ecology 1 December 2006 Hans-Sigrist-Symposium: Biological Invasions Hans-Sigrist-Stiftung 9.00 Prof. Dr. David M Richardson (Centre for Invasion Biology. Dr. Bruno Baur (Conservation Biology, Department of Integrative Biology, University of Basel

  14. Similarity Search in Biological and Engineering Databases Hans-Peter Kriegel, Martin Pfeifle, Stefan Schonauer

    E-Print Network [OSTI]

    Schönauer, Stefan

    applications which are presented in this article are functional classification of proteins in biological search grows in application areas such as multimedia, medical imaging, molecular biology, computer aided imaging and computer aided design. In recent years, considerable work on similarity search in database

  15. Computational and Systems Biology DOI: 10.1039/b921381n

    E-Print Network [OSTI]

    Babu, M. Madan

    Computational and Systems Biology DOI: 10.1039/b921381n Over the last few decades, we have all in this themed issue of Molecular BioSystems entitled ``Computational and Systems Biology''. The excitement contains papers that use contemporary computational and systems approaches that involve analysis

  16. Interfacial Engineering of Molecular Photovoltaics

    E-Print Network [OSTI]

    Shelton, Steven Wade

    2014-01-01

    Engineering of Molecular Photovoltaics by Steven WadeEngineering of Molecular Photovoltaics Copyright © 2014 byEngineering of Molecular Photovoltaics by Steven Wade

  17. Radiation physics, biophysics, and radiation biology. Progress report, December 1, 1993--November 30, 1994

    SciTech Connect (OSTI)

    Hall, E.J.; Zaider, M.

    1994-05-01

    Research at the Center for Radiological Research is a blend of physics, chemistry and biology and epitomizes the multidisciplinary approach towards understanding the mechanisms involved in the health problems resulting from human exposure to ionizing radiations. To an increasing extent, the focus of attention is on biochemistry and the application of the techniques of molecular biology to the problems of radiation biology. Research highlights from the past year are briefly described.

  18. Molecular display of synthetic oligonucleotide libraries and their analysis with high throughput DNA sequencing

    E-Print Network [OSTI]

    Larman, Harry Benjamin

    2012-01-01

    High throughput methods in molecular biology have changed the landscape of biomedical research. In particular, advances in massively parallel DNA sequencing and synthesis technologies are defining our genomes and the ...

  19. Encoded hydrogel microparticles for high-throughput molecular diagnostics and personalized medicine

    E-Print Network [OSTI]

    Chapin, Stephen Clifford

    2012-01-01

    The ability to accurately detect and quantify biological molecules in complex mixtures is crucial in basic research as well as in clinical settings. Advancements in genetic analysis, molecular diagnostics, and patient-tailored ...

  20. Bioengineered Probes for Molecular Magnetic Resonance Imaging in the Nervous System

    E-Print Network [OSTI]

    Hsieh, Vivian

    The development of molecular imaging probes has changed the nature of neurobiological research. Some of the most notable successes have involved the use of biological engineering techniques for the creation of fluorescent ...

  1. Extracting information from biological networks

    E-Print Network [OSTI]

    Chindelevitch, Leonid Alexandrovich

    2010-01-01

    Systems biology, the study of biological systems in a holistic manner, has been catalyzed by a dramatic improvement in experimental techniques, coupled with a constantly increasing availability of biological data. The ...

  2. COLLEGE OF ENGINEERING Biological Engineering

    E-Print Network [OSTI]

    Walter, M.Todd

    COLLEGE OF ENGINEERING Biological Engineering Undergraduate Class of 2013 Post-Graduation Report The Department Biological and Environmental Engineering (BEE) offers a bachelor degree program in Biological Engineering and a bachelor degree program in Environmental Engineering. Cornell Career Services surveys

  3. Radiation physics, biophysics, and radiation biology

    SciTech Connect (OSTI)

    Hall, E.J.

    1992-05-01

    The following research programs from the Center for Radiological Research of Columbia University are described: Design and development of a new wall-less ultra miniature proportional counter for nanodosimetry; some recent measurements of ionization distributions for heavy ions at nanometer site sizes with a wall-less proportional counter; a calculation of exciton energies in periodic systems with helical symmetry: application to a hydrogen fluoride chain; electron energy-loss function in polynucleotide and the question of plasmon excitation; a non-parametric, microdosimetric-based approach to the evaluation of the biological effects of low doses of ionizing radiation; high-LET radiation risk assessment at medium doses; high-LET radiobiological effects: increased lesion severity or increased lesion proximity; photoneutrons generated by high energy medical linacs; the biological effectiveness of neutrons; implications for radiation protection; molecular characterization of oncogenes induced by neutrons; and the inverse dose-rate effect for oncogenic transformation by charged particles is LET dependent.

  4. Biological Conversion of Sugars To Hydrocarbons | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Biological Conversion of Sugars To Hydrocarbons Biological Conversion of Sugars To Hydrocarbons PDF explaining the biological process of bioenergy Biological Conversion of Sugars...

  5. Biological effectiveness of neutrons: Research needs

    SciTech Connect (OSTI)

    Casarett, G.W.; Braby, L.A.; Broerse, J.J.; Elkind, M.M.; Goodhead, D.T.; Oleinick, N.L.

    1994-02-01

    The goal of this report was to provide a conceptual plan for a research program that would provide a basis for determining more precisely the biological effectiveness of neutron radiation with emphasis on endpoints relevant to the protection of human health. This report presents the findings of the experts for seven particular categories of scientific information on neutron biological effectiveness. Chapter 2 examines the radiobiological mechanisms underlying the assumptions used to estimate human risk from neutrons and other radiations. Chapter 3 discusses the qualitative and quantitative models used to organize and evaluate experimental observations and to provide extrapolations where direct observations cannot be made. Chapter 4 discusses the physical principles governing the interaction of radiation with biological systems and the importance of accurate dosimetry in evaluating radiation risk and reducing the uncertainty in the biological data. Chapter 5 deals with the chemical and molecular changes underlying cellular responses and the LET dependence of these changes. Chapter 6, in turn, discusses those cellular and genetic changes which lead to mutation or neoplastic transformation. Chapters 7 and 8 examine deterministic and stochastic effects, respectively, and the data required for the prediction of such effects at different organizational levels and for the extrapolation from experimental results in animals to risks for man. Gaps and uncertainties in this data are examined relative to data required for establishing radiation protection standards for neutrons and procedures for the effective and safe use of neutron and other high-LET radiation therapy.

  6. Work with Biological Materials

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Work with Biological Materials Print Planning A complete Experiment Safety Sheet (ESS) is required before work can be done at the ALS. This ESS is either a part of the proposal...

  7. Vibrations, Quanta and Biology

    E-Print Network [OSTI]

    S. F. Huelga; M. B. Plenio

    2013-06-27

    Quantum biology is an emerging field of research that concerns itself with the experimental and theoretical exploration of non-trivial quantum phenomena in biological systems. In this tutorial overview we aim to bring out fundamental assumptions and questions in the field, identify basic design principles and develop a key underlying theme -- the dynamics of quantum dynamical networks in the presence of an environment and the fruitful interplay that the two may enter. At the hand of three biological phenomena whose understanding is held to require quantum mechanical processes, namely excitation and charge transfer in photosynthetic complexes, magneto-reception in birds and the olfactory sense, we demonstrate that this underlying theme encompasses them all, thus suggesting its wider relevance as an archetypical framework for quantum biology.

  8. Method and apparatus for the gas phase decontamination of chemical and biological agents

    DOE Patents [OSTI]

    O'Neill, Hugh J.; Brubaker, Kenneth L.

    2003-10-07

    An apparatus and method for decontaminating chemical and biological agents using the reactive properties of both the single atomic oxygen and the hydroxyl radical for the decontamination of chemical and biological agents. The apparatus is self contained and portable and allows for the application of gas reactants directly at the required decontamination point. The system provides for the use of ultraviolet light of a specific spectral range to photolytically break down ozone into molecular oxygen and hydroxyl radicals where some of the molecular oxygen is in the first excited state. The excited molecular oxygen will combine with water vapor to produce two hydroxyl radicals.

  9. Biology Mathematics Connection Program Integrating Mathematics and Biology Program

    E-Print Network [OSTI]

    Biology Mathematics Connection Program Integrating Mathematics and Biology Program BMC pioneered a series of instructional modules for use in high school mathematics and biology classrooms to highlight the interconnections between the mathematical and biological sciences. IMB follows up by developing the BMC modules

  10. Marine Biology Is Marine Biology right for me?

    E-Print Network [OSTI]

    Martin, Ralph R.

    Marine Biology Is Marine Biology right for me? If you have an interest in learning about life in the sea then Marine Biology may be a good option for you. You will need good time management skills a marine biology degree are wide-ranging and provide a good basis for employment in almost any sector

  11. 7th Annual Systems Biology Symposium: Systems Biology and Engineering

    SciTech Connect (OSTI)

    Galitski, Timothy P.

    2008-04-01

    Systems biology recognizes the complex multi-scale organization of biological systems, from molecules to ecosystems. The International Symposium on Systems Biology has been hosted by the Institute for Systems Biology in Seattle, Washington, since 2002. The annual two-day event gathers the most influential researchers transforming biology into an integrative discipline investingating complex systems. Engineering and application of new technology is a central element of systems biology. Genome-scale, or very small-scale, biological questions drive the enigneering of new technologies, which enable new modes of experimentation and computational analysis, leading to new biological insights and questions. Concepts and analytical methods in engineering are now finding direct applications in biology. Therefore, the 2008 Symposium, funded in partnership with the Department of Energy, featured global leaders in "Systems Biology and Engineering."

  12. Complex biological and bio-inspired systems

    SciTech Connect (OSTI)

    Ecke, Robert E [Los Alamos National Laboratory

    2009-01-01

    The understanding and characterization ofthe fundamental processes of the function of biological systems underpins many of the important challenges facing American society, from the pathology of infectious disease and the efficacy ofvaccines, to the development of materials that mimic biological functionality and deliver exceptional and novel structural and dynamic properties. These problems are fundamentally complex, involving many interacting components and poorly understood bio-chemical kinetics. We use the basic science of statistical physics, kinetic theory, cellular bio-chemistry, soft-matter physics, and information science to develop cell level models and explore the use ofbiomimetic materials. This project seeks to determine how cell level processes, such as response to mechanical stresses, chemical constituents and related gradients, and other cell signaling mechanisms, integrate and combine to create a functioning organism. The research focuses on the basic physical processes that take place at different levels ofthe biological organism: the basic role of molecular and chemical interactions are investigated, the dynamics of the DNA-molecule and its phylogenetic role are examined and the regulatory networks of complex biochemical processes are modeled. These efforts may lead to early warning algorithms ofpathogen outbreaks, new bio-sensors to detect hazards from pathomic viruses to chemical contaminants. Other potential applications include the development of efficient bio-fuel alternative-energy processes and the exploration ofnovel materials for energy usages. Finally, we use the notion of 'coarse-graining,' which is a method for averaging over less important degrees of freedom to develop computational models to predict cell function and systems-level response to disease, chemical stress, or biological pathomic agents. This project supports Energy Security, Threat Reduction, and the missions of the DOE Office of Science through its efforts to accurately model biological systems at the molecular and cellular level. The project's impact encompasses applications to biofuels, to novel sensors and to materials with broad use for energy or threat reduction. The broad, interdisciplinary approach of CNLS offers the unparalleled strength of combining science backgrounds and expertise -a unique and important asset in attacking the complex science of biological organisms. This approach also allows crossfertilization, with concepts and techniques transferring across field boundaries.

  13. 1085Research Article Kinesin-1 is a molecular transporter that trafficks along

    E-Print Network [OSTI]

    at speeds of up to 1 m second­1 and exchanged into cortically labelled clusters at microtubule ends and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK 2 CRUK Clinical Centre at Leeds, Leeds Institute of Molecular Medicine, St James University Hospital, Leeds, LS9 7TF, UK

  14. BASAL CLADES AND MOLECULAR SYSTEMATICS OF HETEROMYID RODENTS

    E-Print Network [OSTI]

    Riddle, Brett R.

    , they may be superior to nuclear genes for resolving short, basal branches. Our molecular data (2,381 base of Zoology and Department of Biology, Occidental College, Los Angeles, CA 90041, USA (JCH, ER) Department pairs for the 3-gene data set) affirm the monophyly of the family and resolve the major basal clades

  15. DISCOVERING BRAIN MECHANISMS AND THE RULES OF MOLECULAR

    E-Print Network [OSTI]

    Stengel, Robert F.

    DISCOVERING BRAIN MECHANISMS AND THE RULES OF MOLECULAR BIOLOGY Paul Shapshak, PhD*1 and Robert-324-2723 ABSTRACT The human genome has approximately 30,000 genes. Brain cells express at least 15,000. The human brain is subject to many acute and chronic diseases including viral encephalitis, AIDS/HIV Associated

  16. Microscale Swimming: The Molecular Dynamics Approach D. C. Rapaport*

    E-Print Network [OSTI]

    Rapaport, Dennis C.

    -dimensional swimming bodies employing a variety of propulsion mechanisms--motivated by biological and microrobotic among body designs and propulsion mechanisms. DOI: 10.1103/PhysRevLett.99.238101 PACS numbers: 47.63.Gd-propelled motion of microscopic bodies immersed in a fluid medium is studied using molecular dynamics simulation

  17. The use of molecular tools in Parks Canada Agency

    E-Print Network [OSTI]

    Blouin-Demers, Gabriel

    species inventory knowledge is crucial for park management and biodiversity monitoring #12;Outline of genetics to preserve species as dynamic entities ..." · "a mixture of ecology, molecular biology restoration Protected areas management #12;Parks Canada and conservation · Parks Canada is a world leader

  18. Biochemistry and Molecular Biophysics

    E-Print Network [OSTI]

    Sharp, Kim

    cell with a monopolar spindle shows a gradient of Aurora B phosphorylation spreading outward from; molecular immunology; protein structure, dynamics and folding; enzymology; regulation of metabolism; RNA

  19. Molecular Phylogenetics (Hannes Luz)

    E-Print Network [OSTI]

    Spang, Rainer

    Molecular Phylogenetics (Hannes Luz) Contents: · Phylogenetic Trees, basic notions · A character Berlin, 2007) · Martin Vingron, Hannes Luz, Jens Stoye, Lecture notes on 'Al- gorithms for Phylogenetic

  20. Towards a Semantic Lexicon for Biological Language Processing

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Verspoor, Karin

    2005-01-01

    This paper explores the use of the resources in the National Library of Medicine's Unified Medical Language System (UMLS) for the construction of a lexicon useful for processing texts in the field of molecular biology. A lexicon is constructed from overlapping terms in the UMLS SPECIALIST lexicon and the UMLS Metathesaurus to obtain both morphosyntactic and semantic information for terms, and the coverage of a domain corpus is assessed. Over 77% of tokens in the domain corpus are found in the constructed lexicon, validating the lexicon's coverage of the most frequent terms in the domain and indicating that the constructedmore »lexicon is potentially an important resource for biological text processing.« less

  1. Fish Biology Introduction

    E-Print Network [OSTI]

    Jochem, Frank J.

    Lab 10: Fish Biology Introduction The effective management of fish populations requires knowledge of the growth rate of the fish. This requires determination of the age of fish to develop a relationship between the size and age of fish. For an inventory, this information provides insights to evaluate the potential

  2. Chemistry & Biology Brief Communication

    E-Print Network [OSTI]

    Herschlag, Dan

    . In each of these cases the native hydroxyl group interacts with a purine exocy- clic amine. Our resultsChemistry & Biology Brief Communication 20 -Fluoro Substituents Can Mimic Native 20 -Hydroxyls signature for tertiary interac- tions between 20 -hydroxyl groups and exocyclic amino groups within RNA

  3. Chemistry & Biology Perspective

    E-Print Network [OSTI]

    Williams, Loren

    Chemistry & Biology Perspective The Origin of RNA and ``My Grandfather's Axe'' Nicholas V. Hud,1 *Correspondence: hud@gatech.edu http://dx.doi.org/10.1016/j.chembiol.2013.03.012 The origin of RNA is one

  4. Chemistry and Chemical Biology

    E-Print Network [OSTI]

    Linhardt, Robert J.

    /polymeric materials for electronics or energy storage, and polyelectrolyte membranes for fuel cell applications. http projects in emerging fields of science and technology that lie at the intersection between chemistry Biology at Rensselaer invites applications from students interested in pursuing a Ph.D. degree

  5. Biological Engineering 2014-2015 BIOLOGICAL ENGINEERING PROGRAM PROGRESS FORM

    E-Print Network [OSTI]

    Walter, M.Todd

    Biological Engineering 2014-2015 8 BIOLOGICAL ENGINEERING PROGRAM PROGRESS FORM Applies to students Calculus for Engineers I* MATH 1910 (4) ______ _____ _____ Calculus for Engineers II* MATH 1920 (4) ______ _____ _____ Engineering Math* (Differential Equations) MATH 2930 (4) ______ _____ _____ Engineering Math* (Linear Algebra

  6. Microscale swimming: The molecular dynamics approach

    E-Print Network [OSTI]

    D. C. Rapaport

    2007-12-06

    The self-propelled motion of microscopic bodies immersed in a fluid medium is studied using molecular dynamics simulation. The advantage of the atomistic approach is that the detailed level of description allows complete freedom in specifying the swimmer design and its coupling with the surrounding fluid. A series of two-dimensional swimming bodies employing a variety of propulsion mechanisms -- motivated by biological and microrobotic designs -- is investigated, including the use of moving limbs, changing body shapes and fluid jets. The swimming efficiency and the nature of the induced, time-dependent flow fields are found to differ widely among body designs and propulsion mechanisms.

  7. Environmental Molecular Sciences Laboratory 2004 Annual Report

    SciTech Connect (OSTI)

    White, Julia C.

    2005-04-17

    This 2004 Annual Report describes the research and accomplishments of staff and users of the W.R. Wiley Environmental Molecular Sciences Laboratory (EMSL), located in Richland, Washington. EMSL is a multidisciplinary, national scientific user facility and research organization, operated by Pacific Northwest National Laboratory (PNNL) for the U.S. Department of Energy's Office of Biological and Environmental Research. The resources and opportunities within the facility are an outgrowth of the U.S. Department of Energy's (DOE) commitment to fundamental research for understanding and resolving environmental and other critical scientific issues.

  8. Biology 472 Spring 2009 Biology of Amphibians and Reptiles

    E-Print Network [OSTI]

    Jackson, Kate

    Biology 472 Spring 2009 1 Biology of Amphibians and Reptiles Dr. Kate Jackson Office: Science 200 E Encyclopedia of Reptiles and Amphibians. Oxford University Press. (2) Stebbins, R. and R. T. Peterson. 2003 of assorted herps (from labs). #12;Biology 472 Spring 2009 2 · ...know how to access primary sources

  9. Chemistry/Biology Interface Training Program (CBITG) Goals of the Program and Rationale for the Program Organization

    E-Print Network [OSTI]

    Thomas, David D.

    2011 Chemistry/Biology Interface Training Program (CBITG) Goals of the Program and Rationale recruited by the Chemistry, BMBB, Medicinal Chemistry and Microbiology Departments, at a stage of interest (e.g., synthetic/mechanistic chemistry, molecular biology, mechanistic enzymology, medicinal

  10. BACHELOR OF SCIENCE BIOLOGY GENERAL OPTION

    E-Print Network [OSTI]

    Kemp, Brian M.

    * OR 201 Physics 4 hrs. PHYSICS 102* OR 202 Physics 4 hrs. General Biology Option Requirements: CellBACHELOR OF SCIENCE ­ BIOLOGY GENERAL OPTION A Bachelor of Science degree from Washington State Requirements: Grade BIOLOGY 106 General Biology 4 hrs. BIOLOGY 107 General Biology 4 hrs. BIOLOGY 301 General

  11. Molecular Evolution, Networks in From: Meyers, R.A. (ed.) Encyclopedia of Complexity and System Science. Springer, Heidelberg

    E-Print Network [OSTI]

    Wagner, Andreas

    Molecular Evolution, Networks in From: Meyers, R.A. (ed.) Encyclopedia of Complexity and System of Biochemistry Computational Biology and Bioinformatics Building Y27 Winterthurerstrasse 190 CH-8057 Zurich

  12. Mechanism of Molecular Ordering in Monolayer Liquid Crystal Films David L. Patrick, Victor J. Cee, and Thomas P. Beebe, Jr.*

    E-Print Network [OSTI]

    Patrick, David L.

    length scales with scanning probe micros- copy (SPM).1 Aside from investigations of biological macro- molecules, liquid crystal films are probably the most studied molecular system by SPM.2 It is therefore

  13. Modular architecture in biological networks

    E-Print Network [OSTI]

    Ramachandran, Gopal (Gopal Sebastian)

    2007-01-01

    In the past decade, biology has been revolutionized by an explosion in the availability of data. Translating this new wealth of information into meaningful biological insights and clinical breakthroughs will require a ...

  14. Experiment design for systems biology

    E-Print Network [OSTI]

    Apgar, Joshua Farley

    2009-01-01

    Mechanism-based chemical kinetic models are increasingly being used to describe biological signaling. Such models serve to encapsulate current understanding of pathways and to enable insight into complex biological processes. ...

  15. Departments of Chemistry and Pharmacology Center for Structural Biology

    E-Print Network [OSTI]

    Meiler, Jens

    Departments of Chemistry and Pharmacology Center for Structural Biology Lecture 17 Jens Meiler #12.2 0.0 0.2 0.4 0.6 0.8 1.0 0 2 4 6 8 10 12 14 s I(s)a) b) c) d) e) f) Chemical Structure #12;Machine from constitution using atomic weights, atomic radii and standard bond lengths Molecular Weight 3 7 74

  16. Systems Biology | More Science | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ORNL brings together multidisciplinary expertise and special facilities in genomics, computational biology, plant sciences, microbiology, microbial ecology, biophysics,...

  17. Systems Biology | Clean Energy | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ORNL brings together multidisciplinary expertise and special facilities in genomics, computational biology, plant sciences, microbiology, microbial ecology, biophysics,...

  18. Abengoa Mojave Final Biological Opinion

    Broader source: Energy.gov [DOE]

    Biological Opinion on Mojave Solar, LLC's Mojave Solar Project, San Bernardino County, California (8-8-11-F-3)

  19. Biological particle identification apparatus

    DOE Patents [OSTI]

    Salzman, Gary C. (Los Alamos, NM); Gregg, Charles T. (Los Alamos, NM); Grace, W. Kevin (Los Alamos, NM); Hiebert, Richard D. (Los Alamos, NM)

    1989-01-01

    An apparatus and method for making multiparameter light scattering measurements from suspensions of biological particles is described. Fourteen of the sixteen Mueller matrix elements describing the particles under investigation can be substantially individually determined as a function of scattering angle and probing radiations wavelength, eight elements simultaneously for each of two apparatus configurations using an apparatus which incluees, in its simplest form, two polarization modulators each operating at a chosen frequency, one polarizer, a source of monochromatic electromagnetic radiation, a detector sensitive to the wavelength of radiation employed, eight phase-sensitive detectors, and appropriate electronics. A database of known biological particle suspensions can be assembled, and unknown samples can be quickly identified once measurements are performed on it according to the teachings of the subject invention, and a comparison is made with the database.

  20. Proportional Relationships in Biology

    E-Print Network [OSTI]

    Lega, Joceline

    Proportional Relationships in Biology #12;Bell Ringer... 1) Are 2/3 and 6/12 proportional? 1) No; 6/12 = 1/2 ! 2/3 2) Are 2/3 and 10/15 proportional? 1) Yes; 2/3 = (2*5)/(3*5) = 10/15 3) Are 2/3 and 4/9 proportional? 1) No; both are simplified #12;Proportional Shapes · What does it mean for two shapes

  1. Computational biology and high performance computing

    E-Print Network [OSTI]

    Shoichet, Brian

    2011-01-01

    Paper in Computational Biology The First Step Beyond theM . Glaeser, Mol. & Cell Biology, UCB and Life SciencesLBNL-44460 Computational Biology and High Performance

  2. Nutritional systems biology of type 2 diabetes

    E-Print Network [OSTI]

    Zhao, Y; Barrere-Cain, RE; Yang, X

    2015-01-01

    HF (2015) Circadian systems biology in Metazoa. BriefingsNutritional systems biology: defini- tions and approaches.PAPER Nutritional systems biology of type 2 diabetes Yuqi

  3. DEPARTMENT OF DEPARTMENT OF BIOLOGY

    E-Print Network [OSTI]

    Turc, Catalin

    Masters of Science Degree Plan A: Thesis DEPARTMENT OF BIOLOGY CASE WESTERN RESERVE UNIVERSITY #12;DEPARTMENT OF BIOLOGY Masters of Science Degree (Plan A) Thesis The Plan A Master of Science Degree in Biology is a thesis,graduate degree program.The purpose of the program is to provide advanced exposure

  4. Translational Biology, Medicine, and Health

    E-Print Network [OSTI]

    Crawford, T. Daniel

    Translational Biology, Medicine, and Health PhDProgram Admissions The program seeks highly. PhD Program in Translational Biology, Medicine, and Health Focus Areas Cancer Development, Aging 24016 avanwart@vt.edu · www.tbmh.vt.edu www . tbmh.vt.edu #12;Translational Biology, Medicine

  5. Electron Trapping by Molecular Vibration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Electron Trapping by Molecular Vibration Electron Trapping by Molecular Vibration Print Wednesday, 27 April 2005 00:00 In photoelectron spectroscopy experiments performed at the...

  6. Molecular heat pump

    E-Print Network [OSTI]

    Dvira Segal; Abraham Nitzan

    2005-10-11

    We propose a novel molecular device that pumps heat against a thermal gradient. The system consists of a molecular element connecting two thermal reservoirs that are characterized by different spectral properties. The pumping action is achieved by applying an external force that periodically modulates molecular levels. This modulation affects periodic oscillations of the internal temperature of the molecule and the strength of its coupling to each reservoir resulting in a net heat flow in the desired direction. The heat flow is examined in the slow and fast modulation limits and for different modulation waveforms, thus making it possible to optimize the device performance.

  7. Biological Materials that REQUIRE an Export License ALL biological agents and biologically derived substances specifically developed, configured,

    E-Print Network [OSTI]

    Jornsten, Rebecka

    Biological Materials that REQUIRE an Export License · ALL biological agents and biologically nationals or to be exported. List of Biological Materials that MAY Require an Export License (including

  8. Biology/Marine Biology Prizes/Awards/Scholarships 2004/05 University Medal in Biology Anna London

    E-Print Network [OSTI]

    Gunawardena, Arunika

    Biology/Marine Biology Prizes/Awards/Scholarships 2004/05 University Medal in Biology Anna London University Medal in Marine Biology Jennifer Frail Hugh P. Bell Scholarships Ivy Whitehorn, Jennifer Frail

  9. Biology/Marine Biology Prizes/Awards/Scholarships 2003/04 University Medal in Biology Andrew Gillis

    E-Print Network [OSTI]

    Gunawardena, Arunika

    Biology/Marine Biology Prizes/Awards/Scholarships 2003/04 University Medal in Biology Andrew Gillis University Medal in Marine Biology Kent Russell Hugh P. Bell Scholarships Andrew Gillis, Stephanie Wood

  10. Biology/Marine Biology Prizes/Awards/Scholarships 2006/07 University Medal in Biology Yassein Shamout

    E-Print Network [OSTI]

    Gunawardena, Arunika

    Biology/Marine Biology Prizes/Awards/Scholarships 2006/07 University Medal in Biology Yassein Shamout University Medal in Marine Biology Sophie Whoriskey Hugh P. Bell Scholarships Shana Watanabe

  11. Biology/Marine Biology Prizes/Awards/Scholarships 2007/08 University Medal in Biology Faiza Siddiqi, Ashley Smith

    E-Print Network [OSTI]

    Gunawardena, Arunika

    Biology/Marine Biology Prizes/Awards/Scholarships 2007/08 University Medal in Biology Faiza Siddiqi, Ashley Smith University Medal in Marine Biology Shana Watanabe Hugh P. Bell Scholarships Faiza Siddiqi

  12. Biology/Marine Biology Prizes/Awards/Scholarships 2005/06 University Medal in Biology Oliver Barker

    E-Print Network [OSTI]

    Gunawardena, Arunika

    Biology/Marine Biology Prizes/Awards/Scholarships 2005/06 University Medal in Biology Oliver Barker University Medal in Marine Biology Katy Garant Hugh P. Bell Scholarships Oliver Barker, Alison Green, Carmen

  13. Biology/Marine Biology Prizes/Awards/Scholarships 2002/03 University Medal in Biology Kate Turner

    E-Print Network [OSTI]

    Gunawardena, Arunika

    Biology/Marine Biology Prizes/Awards/Scholarships 2002/03 University Medal in Biology Kate Turner University Medal in Marine Biology Shane Gero University Medal in French Annette Woods University Medal

  14. CFTF | Carbon Fiber Technology Facility | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    BTRIC CNMS CSMB CFTF Working with CFTF HFIR MDF NTRC OLCF SNS Carbon Fiber Technology Facility Home | User Facilities | CFTF CFTF | Carbon Fiber Technology Facility SHARE Oak...

  15. Green Algae as Model Organisms for Biological Fluid Dynamics

    E-Print Network [OSTI]

    Goldstein, Raymond E

    2014-01-01

    In the past decade the volvocine green algae, spanning from the unicellular $Chlamydomonas$ to multicellular $Volvox$, have emerged as model organisms for a number of problems in biological fluid dynamics. These include flagellar propulsion, nutrient uptake by swimming organisms, hydrodynamic interactions mediated by walls, collective dynamics and transport within suspensions of microswimmers, the mechanism of phototaxis, and the stochastic dynamics of flagellar synchronization. Green algae are well suited to the study of such problems because of their range of sizes (from 10 $\\mu$m to several millimetres), their geometric regularity, the ease with which they can be cultured and the availability of many mutants that allow for connections between molecular details and organism-level behavior. This review summarizes these recent developments and highlights promising future directions in the study of biological fluid dynamics, especially in the context of evolutionary biology, that can take advantage of these re...

  16. Green Algae as Model Organisms for Biological Fluid Dynamics

    E-Print Network [OSTI]

    Raymond E. Goldstein

    2014-09-08

    In the past decade the volvocine green algae, spanning from the unicellular $Chlamydomonas$ to multicellular $Volvox$, have emerged as model organisms for a number of problems in biological fluid dynamics. These include flagellar propulsion, nutrient uptake by swimming organisms, hydrodynamic interactions mediated by walls, collective dynamics and transport within suspensions of microswimmers, the mechanism of phototaxis, and the stochastic dynamics of flagellar synchronization. Green algae are well suited to the study of such problems because of their range of sizes (from 10 $\\mu$m to several millimetres), their geometric regularity, the ease with which they can be cultured and the availability of many mutants that allow for connections between molecular details and organism-level behavior. This review summarizes these recent developments and highlights promising future directions in the study of biological fluid dynamics, especially in the context of evolutionary biology, that can take advantage of these remarkable organisms.

  17. Molecular Cell Short Review

    E-Print Network [OSTI]

    Walter, Nils G.

    '' is the most critical and challenging ques- tion in any murder story, even if it plays out on the molec- ular of an unsolved molecular murder mystery is found in the seemingly simple RNA backbone transesterification

  18. Cellular and Molecular Bioengineering

    E-Print Network [OSTI]

    1 23 Cellular and Molecular Bioengineering ISSN 1865-5025 Volume 6 Number 1 Cel. Mol. Bioeng. (2013,2 and ANATOLY B. KOLOMEISKY 2 1 Department of Bioengineering, Rice University, Houston, TX 77005, USA; and 2

  19. 1 Biochemistry and Molecular Medicine BIOCHEMISTRY AND MOLECULAR

    E-Print Network [OSTI]

    Vertes, Akos

    1 Biochemistry and Molecular Medicine BIOCHEMISTRY AND MOLECULAR MEDICINE GRADUATE Master's program · Master of Science in the field of molecular biochemistry and bioinformatics (http://bulletin.gwu.edu/arts-sciences/ biochemistry-molecular-medicine/ms) FACULTY University Professor F. Murad Professors P. Berg, V. Hu, A. Kumar

  20. Biology/Marine Biology Prizes/Awards/Scholarships 2010/11 University Medal in Biology Jennifer Kalil

    E-Print Network [OSTI]

    Gunawardena, Arunika

    Biology/Marine Biology Prizes/Awards/Scholarships 2010/11 University Medal in Biology Jennifer Kalil University Medal in Marine Biology John O'Brien University Silver Medal John O'Brien Hugh P. Bell Developmental Biology Prize Alexandra Preston Vemco Scholarship in Marine Biology Jessica Carriere

  1. Biology/Marine Biology Prizes/Awards/Scholarships 2011/12 University Medal in Biology Jaime Wertman

    E-Print Network [OSTI]

    Gunawardena, Arunika

    Biology/Marine Biology Prizes/Awards/Scholarships 2011/12 University Medal in Biology Jaime Wertman University Medal in Marine Biology Cylia Civelek Hugh P. Bell Scholarships Sarah McBoyle, Lauren Kay, Daniel Developmental Biology Prize Siwar Arda Vemco Scholarship in Marine Biology Stacey Henderson Cecelia Rajaratnam

  2. Molecular Science Computing Facility Scientific Challenges: Linking Across Scales

    SciTech Connect (OSTI)

    De Jong, Wibe A.; Windus, Theresa L.

    2005-07-01

    The purpose of this document is to define the evolving science drivers for performing environmental molecular research at the William R. Wiley Environmental Molecular Sciences Laboratory (EMSL) and to provide guidance associated with the next-generation high-performance computing center that must be developed at EMSL's Molecular Science Computing Facility (MSCF) in order to address this critical research. The MSCF is the pre-eminent computing facility?supported by the U.S. Department of Energy's (DOE's) Office of Biological and Environmental Research (BER)?tailored to provide the fastest time-to-solution for current computational challenges in chemistry and biology, as well as providing the means for broad research in the molecular and environmental sciences. The MSCF provides integral resources and expertise to emerging EMSL Scientific Grand Challenges and Collaborative Access Teams that are designed to leverage the multiple integrated research capabilities of EMSL, thereby creating a synergy between computation and experiment to address environmental molecular science challenges critical to DOE and the nation.

  3. Montana State University 1 Cell Biology and

    E-Print Network [OSTI]

    Maxwell, Bruce D.

    Montana State University 1 Cell Biology and Neuroscience The department participates: MSU's programs in the biological sciences are distributed across multiple departments. MSU does not have a single Department of Biology. For additional options see Biological Sciences (http

  4. Molecular Science Research Center annual report

    SciTech Connect (OSTI)

    Knotek, M.L.

    1991-01-01

    The Chemical Structure and Dynamics group is studying chemical kinetics and reactions dynamics of terrestrial and atmospheric processes as well as the chemistry of complex waste forms and waste storage media. Staff are using new laser systems and surface-mapping techniques in combination with molecular clusters that mimic adsorbate/surface interactions. The Macromolecular Structure and Dynamics group is determining biomolecular structure/function relationships for processes the control the biological transformation of contaminants and the health effects of toxic substances. The Materials and Interfaces program is generating information needed to design and synthesize advanced materials for the analysis and separation of mixed chemical waste, the long-term storage of concentrated hazardous materials, and the development of chemical sensors for environmental monitoring of various organic and inorganic species. The Theory, Modeling, and Simulation group is developing detailed molecular-level descriptions of the chemical, physical, and biological processes in natural and contaminated systems. Researchers are using the full spectrum of computational techniques. The Computer and Information Sciences group is developing new approaches to handle vast amounts of data and to perform calculations for complex natural systems. The EMSL will contain a high-performance computing facility, ancillary computing laboratories, and high-speed data acquisition systems for all major research instruments.

  5. Autofermentative Biological Hydrogen Production by Cyanobacteria...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Autofermentative Biological Hydrogen Production by Cyanobacteria Autofermentative Biological Hydrogen Production by Cyanobacteria Presentation by Charles Dismukes, Rutgers...

  6. Biological Control of Saltcedar 

    E-Print Network [OSTI]

    Knutson, Allen E.; DeLoach, C. Jack; Muegge, Mark A.

    2003-10-21

    stream_source_info pdf_1854.pdf.txt stream_content_type text/plain stream_size 8896 Content-Encoding ISO-8859-1 stream_name pdf_1854.pdf.txt Content-Type text/plain; charset=ISO-8859-1 A sustainable approach using insect... organisms to suppress saltcedar. This method is called biological control. To help control saltcedar, insects that feed only on the plant are being intro- duced into Texas and the western United States. S Invader of rivers, lakes and wetlands Saltcedar, also...

  7. Biological and Environmental Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room News PublicationsAudits & InspectionsBeryllium andSamplerBiological Imaging by

  8. Dynamic properties of molecular motors in the divided-pathway model Rahul Kumar Das and Anatoly B. Kolomeisky*

    E-Print Network [OSTI]

    Dynamic properties of molecular motors in the divided-pathway model Rahul Kumar Das and Anatoly B on the web 9th April 2009 DOI: 10.1039/b901214a The mechanisms of molecular motors transport are important for understanding multiple biological processes. Recent single-molecule experiments indicate that motor proteins

  9. Department of Biology and Marine Biology Merit Scholarship Fund: The Department of Biology and Marine Biology Merit Scholarship is hereby created as a

    E-Print Network [OSTI]

    Olszewski Jr., Edward A.

    Department of Biology and Marine Biology Merit Scholarship Fund: The Department of Biology and Marine Biology Merit Scholarship is hereby created as a named fund at the University of North Carolina at Wilmington. The scholarship is being created by the Department of Biology and Marine Biology and will be used

  10. A determination of air-sea gas exchange and upper ocean biological production from five noble gasses and tritiugenic helium-3

    E-Print Network [OSTI]

    Stanley, Rachel H. R

    2007-01-01

    The five noble gases (helium, neon, argon, krypton, and xenon) are biologically and chemically inert, making them ideal oceanographic tracers. Additionally, the noble gases have a wide range of solubilities and molecular ...

  11. Healthcare & Biology Licenses Available | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ID 200802058, 200802114) 200802139 Universal Gene Transfer Technology for Gram Positive Bacteria 200802151 Determining Optical Properties of Biological Tissues 200802153 Combined...

  12. CollegeofScience Biological Sciences

    E-Print Network [OSTI]

    Hickman, Mark

    ,populations,and even ecosystems. Our courses will help prepare you for a career in biology,be it in biodiversity

  13. Michael Levitt and Computational Biology

    Office of Scientific and Technical Information (OSTI)

    Levitt, PhD, professor of structural biology at the Stanford University School of Medicine, has won the 2013 Nobel Prize in Chemistry. ... Levitt ... shares the ... prize with...

  14. Plant Vascular Biology 2010

    SciTech Connect (OSTI)

    Ding, Biao

    2014-11-17

    This grant supported the Second International Conference on Plant Vascular Biology (PVB 2010) held July 24-28, 2010 on the campus of Ohio State University, Columbus, Ohio. Biao Ding (Ohio State University; OSU) and David Hannapel (Iowa State University; ISU) served as co-chairs of this conference. Biao Ding served as the local organizer. PVB is defined broadly here to include studies on the biogenesis, structure and function of transport systems in plants, under conditions of normal plant growth and development as well as of plant interactions with pathogens. The transport systems cover broadly the xylem, phloem, plasmodesmata and vascular cell membranes. The PVB concept has emerged in recent years to emphasize the integrative nature of the transport systems and approaches to investigate them.

  15. Coexistence and efficiency of normal and anomalous transport by molecular motors in living cells

    E-Print Network [OSTI]

    Igor Goychuk; Vasyl O. Kharchenko; R. Metzler

    2013-09-26

    Recent experiments reveal both passive subdiffusion of various nanoparticles and anomalous active transport of such particles by molecular motors in the molecularly crowded environment of living biological cells. Passive and active microrheology reveals that the origin of this anomalous dynamics is due to the viscoelasticity of the intracellular fluid. How do molecular motors perform in such a highly viscous, dissipative environment? Can we explain the observed co-existence of the anomalous transport of relatively large particles of 100 to 500 nm in size by kinesin motors with the normal transport of smaller particles by the same molecular motors? What is the efficiency of molecular motors in the anomalous transport regime? Here we answer these seemingly conflicting questions and consistently explain experimental findings in a generalization of the well-known continuous diffusion model for molecular motors with two conformational states in which viscoelastic effects are included.

  16. ATTENTION BIOLOGY/MARINE BIOLOGY If you think that you qualify, bring this to the attention of a biology faculty

    E-Print Network [OSTI]

    Gunawardena, Arunika

    ATTENTION BIOLOGY/MARINE BIOLOGY STUDENTS: If you think that you qualify, bring this to the attention of a biology faculty member and seek their nomination. The Gary Hicks Memorial Award The Gary in the Biology Department at Dalhousie University for 27 years where he taught developmental and plant biology

  17. Biology/Marine Biology Prizes/Awards/Scholarships 2008/09 University Medal in Biology Alyssa Byers-Heinlein

    E-Print Network [OSTI]

    Gunawardena, Arunika

    Biology/Marine Biology Prizes/Awards/Scholarships 2008/09 University Medal in Biology Alyssa Byers-Heinlein University Medal in Marine Biology Matthew Morris Avery Prize Jessica Arbour Hugh P. Bell Scholarships, Elisabeth Oakham Vemco Scholarship in Marine Biology Matthew Morris #12;

  18. Biology/Marine Biology Prizes/Awards/Scholarships 2009/10 University Medal in Biology Jinnie Kim

    E-Print Network [OSTI]

    Gunawardena, Arunika

    Biology/Marine Biology Prizes/Awards/Scholarships 2009/10 University Medal in Biology Jinnie Kim University Medal in Marine Biology Jesse Kelly University Silver Medal Jinnie Kim Hugh P. Bell Scholarships Vemco Scholarship in Marine Biology Jessie Short #12;

  19. Cell Reports Molecular Architecture

    E-Print Network [OSTI]

    Harrison, Stephen C.

    Cell Reports Report Molecular Architecture of the Yeast Monopolin Complex Kevin D. Corbett1 report here biochemical characterization of the monopolin complex subunits Mam1 and Hrr25). In these organisms, sister kinetochore co-orientation in meiosis I depends on the Aurora B/Ipl1 kinase, as well

  20. Biological Engineering integrates life sciences

    E-Print Network [OSTI]

    Chen, Tsuhan

    of biological systems. Biological Engineering impacts the well-being of humans, plants, and animals through and global challenges such as ensuring safe and sustainable food and energy supplies, protecting natural agencies. Products of their efforts help ensure a safe and adequate supply of food and water, create new

  1. Research Councils UK Synthetic biology

    E-Print Network [OSTI]

    Crowther, Paul

    Research Councils UK Synthetic biology #12;Synthetic biology Research funded by the Research a variety of approaches to support innovation and deliver impact from research, including the development of collaborative research programmes, investment in major research capabilities, such as national research

  2. Cheatgrass Biology, Ecology, and Management

    E-Print Network [OSTI]

    Maxwell, Bruce D.

    Cheatgrass Biology, Ecology, and Management Fabián Menalled menalled@montana.edu 406-994-4783 Montana State #12;http://ipm.montana.edu/cropweeds #12;#12;· Biology and identification of brome species secalinus Not found in MT #12;Cheatgrass Japanese brome #12;Pictures from Interactive Encyclopedia of North

  3. Experimental Data from the Proteomics Research Center for Integrative Biology

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Smith, Richard D.

    The possible roles and importance of proteomics are rapidly growing across essentially all areas of biological research. The precise and comprehensive measurement of levels of expressed proteins and their modified forms can provide new insights into the molecular nature of cell-signaling pathways and networks, the cell cycle, cellular differentiation, and other processes relevant to understanding human health and the progression of various disease states. The ability to characterize protein complexes complements this capability, allowing hypotheses to be tested and the biological system operation to be defined. The Proteomics Research Center for Integrative Biology is a national user facility established and funded by the National Institute of General Medical Sciences component of the National Institutes of Health. This Center has been established to serve the biomedical research community by developing and integrating new proteomic technologies for collaborative and service studies, disseminating the new technologies, and training scientists in their use. The Center is housed in DOE’s William R. Wiley Environmental Molecular Sciences Laboratory (EMSL) at the Pacific Northwest National Laboratory.

  4. Effective bridge spectral density for long-range biological energy and charge transfer

    E-Print Network [OSTI]

    Mukamel, Shaul

    Effective bridge spectral density for long-range biological energy and charge transfer Oliver Ku of intermediate bridge sites in energy and charge transfer processes in molecular aggregates of arbitrary size analysis for a donor­acceptor system coupled through a single bridge molecule are presented. © 1996

  5. Molecular Gas in Early-type Galaxies

    E-Print Network [OSTI]

    Alatalo, Katherine Anne

    2012-01-01

    toward the center (first seen in the molecular gas in A+3.4 Molecular Gas Mass . . . . . . .of the molecular gas . . . . . . . . . . 2.4.3 Mass of

  6. PIA - Environmental Molecular Sciences Laboratory (EMSL) User...

    Energy Savers [EERE]

    Molecular Sciences Laboratory (EMSL) User System (ESU) PIA - Environmental Molecular Sciences Laboratory (EMSL) User System (ESU) PIA - Environmental Molecular Sciences Laboratory...

  7. Metal-mediated molecular machines 

    E-Print Network [OSTI]

    Howgego, David Christopher

    2013-06-29

    Nature abounds with ingenious nanoscopic machines employed to carry out all of the requisite tasks that collectively contribute to the molecular basis of life. This thesis focuses primarily on a sub-set known as "molecular ...

  8. Arts & Sciences Biology, B.A.

    E-Print Network [OSTI]

    New Mexico, University of

    6/7/13 Arts & Sciences Biology, B.A. Broad Learning Goals A. Understand basic biological principles, and appreciate the breadth of modern biology. B. Understand and apply the scientific principle to conceptual or experimental problems in biology. C. Present biological data, and interpretations of the data, in written

  9. 1998 Oxford University Press 919932Human Molecular Genetics, 1998, Vol. 7, No. 5 Statistical features of human exons and their flanking

    E-Print Network [OSTI]

    could serve as a standard for future studies so that direct comparisons of results can be made and regulation. As the central theme in molecular biology is the structure­function relationship, distinct

  10. Fundamental Biology of Plants and Plant Pests Goal: Colorado State University will enhance its focus and depth in graduate education and research in fundamental plant

    E-Print Network [OSTI]

    and research in molecular biology and genomics of crop plants and their pests, mechanisms of biological and genomics are opening many new pathways for crop plant improvement and pest management, which will enhance organisms. Build faculty capacity in secondary metabolism and the genomics and population genetics

  11. Loop Quantum Theory Applied to Biology and Nonlinear Whole Biology

    E-Print Network [OSTI]

    Yi-Fang Chang

    2008-01-02

    The loop quantum theory, which constitutes a very small discontinuous space, as new method is applied to biology. The model of protein folding and lungs is proposed. In the model, some known results are used, and four approximate conclusions are obtained: their structures are quantized, their space regions are finite, various singularities correspond to folding and crossed points, and different types of catastrophe exist. Further, based on the inseparability and correlativity of the biological systems, the nonlinear whole biology is proposed, and four basic hypotheses are formed. It may unify reductionism and holism, structuralism and functionalism. Finally, the medical meaning of the theory is discussed briefly.

  12. Comparative Microbial Genomics group CenterforBiologicalSequenceanalysisDepartmentofSystemsBiology

    E-Print Network [OSTI]

    Ussery, David W.

    Comparative Microbial Genomics group CenterforBiologicalSequenceanalysisDepartmentofSystemsBiology Visualisation of Large Amounts of Data Dave Ussery 27 February, 2008 #12;Comparative Microbial Genomics group CenterforBiologicalSequenceanalysisDepartmentofSystemsBiology #12;Comparative Microbial Genomics group

  13. Molecular-beam scattering

    SciTech Connect (OSTI)

    Vernon, M.F.

    1983-07-01

    The molecular-beam technique has been used in three different experimental arrangements to study a wide range of inter-atomic and molecular forces. Chapter 1 reports results of a low-energy (0.2 kcal/mole) elastic-scattering study of the He-Ar pair potential. The purpose of the study was to accurately characterize the shape of the potential in the well region, by scattering slow He atoms produced by expanding a mixture of He in N/sub 2/ from a cooled nozzle. Chapter 2 contains measurements of the vibrational predissociation spectra and product translational energy for clusters of water, benzene, and ammonia. The experiments show that most of the product energy remains in the internal molecular motions. Chapter 3 presents measurements of the reaction Na + HCl ..-->.. NaCl + H at collision energies of 5.38 and 19.4 kcal/mole. This is the first study to resolve both scattering angle and velocity for the reaction of a short lived (16 nsec) electronic excited state. Descriptions are given of computer programs written to analyze molecular-beam expansions to extract information characterizing their velocity distributions, and to calculate accurate laboratory elastic-scattering differential cross sections accounting for the finite apparatus resolution. Experimental results which attempted to determine the efficiency of optically pumping the Li(2/sup 2/P/sub 3/2/) and Na(3/sup 2/P/sub 3/2/) excited states are given. A simple three-level model for predicting the steady-state fraction of atoms in the excited state is included.

  14. Rank 1995-96 1996-97 1997-98 1998-99 1999-00 2000-01 2001-02 2002-03 2003-04 1 Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Sciences Biological Scien

    E-Print Network [OSTI]

    Ullrich, Paul

    Engineering Sociology 3 Sociology 3 Animal Science Animal Science Biochemistry Animal Science Biochem Biological Sciences Biological Sciences Biological Sciences 2 Biochemistry Biochemistry Biochemistry Economics 4 Political Science 2 Political Science 2 Human Development Biochemistry Biochemistry Political

  15. The new biology: beyond the Modern Synthesis

    E-Print Network [OSTI]

    Rose, Michael R; Oakley, Todd H

    2007-01-01

    The Evolution of Biology. New York: Oxford University Press;2003. Woese CR: A new biology for a new century. Microbiol1961, 5:. Comfort A: The biology of senescence. 3rd edition.

  16. Engineering supported membranes for cell biology

    E-Print Network [OSTI]

    Yu, Cheng-han; Groves, Jay T.

    2010-01-01

    membranes in structural biology. J Struct Biol 168:1–2 50.supported membranes for cell biology Cheng-han Yu • Jay T.range problems in cell biology. Because lateral mobility of

  17. Noah A. Rosenberg Department of Biology

    E-Print Network [OSTI]

    Rosenberg, Noah

    Noah A. Rosenberg Department of Biology Stanford University Stanford, CA 94305-5020 USA (650) 721 appointments 2011- Associate Professor, Department of Biology, Stanford University 2009-2011 Associate Professor, Departments of Human Genetics, Ecology & Evolutionary Biology, and Biostatistics, University

  18. THE BUREAU OF COMMERCIAL FISHERIES BIOLOGICAL LABORATORY

    E-Print Network [OSTI]

    THE BUREAU OF COMMERCIAL FISHERIES BIOLOGICAL LABORATORY OXFORD, MARYLAND: PROGRAMS OF COMMERCIAL FISHERIES BIOLOGICAL LABORATORY OXFORD, MARYLAND: PROGRAMS AND PERSPECTIVES Circular 200 Washington, D.C. October 1964 #12;Cover Photo: The Bureau of Commercial Fisheries Biological Laboratory

  19. Biological and Chemical Sciences Department of Biological and Chemical Sciences

    E-Print Network [OSTI]

    and Organic Materials Chromatography Regulatory Science Synthesis and Characterization of Inorganic Materials Synthesis and Characterization of Organic Materials Research Centers International Center for Sensor Science, microbiology, molecular biophysics and biochem- istry; analytical chemistry, inorganic chemistry, materi- als

  20. Biological Responses to Engineered Nanomaterials: Needs for the Next Decade

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Murphy, Catherine; Vartanian, Ariane M.; Geiger, Franz M.; Hamers, Robert J.; Pedersen, Joel A.; Cui, Qiang; Haynes, Christy L.; Carlson, Erin E.; Hernandez, Rigoberto; Klaper, Rebecca D.; et al

    2015-06-09

    The interaction of nanomaterials with biomolecules, cells, and organisms is an enormously vital area of current research, with applications in nanoenabled diagnostics, imaging agents, therapeutics, and contaminant removal technologies. Yet the potential for adverse biological and environmental impacts of nanomaterial exposure is considerable and needs to be addressed to ensure sustainable development of nanomaterials. In this Outlook four research needs for the next decade are outlined: (i) measurement of the chemical nature of nanomaterials in dynamic, complex aqueous environments; (ii) real-time measurements of nanomaterial-biological interactions with chemical specificity; (iii) delineation of molecular modes of action for nanomaterial effects on livingmore »systems as functions of nanomaterial properties; and (iv) an integrated systems approach that includes computation and simulation across orders of magnitude in time and space.« less

  1. An efficient biologically-inspired photocell enhanced by quantum coherence

    E-Print Network [OSTI]

    C. Creatore; M. A. Parker; S. Emmott; A. W. Chin

    2013-07-18

    Artificially reproducing the biological light reactions responsible for the remarkably efficient photon-to-charge conversion in photosynthetic complexes represents a new direction for the future development of photovoltaic devices. Here, we develop such a paradigm and present a model photocell based on the nanoscale architecture of photosynthetic reaction centres that explicitly harnesses the quantum mechanical effects recently discovered in photosynthetic complexes. Quantum interference of photon absorption/emission induced by the dipole-dipole interaction between molecular excited states guarantees an enhanced light-to-current conversion and power generation for a wide range of realistic parameters, opening a promising new route for designing artificial light-harvesting devices inspired by biological photosynthesis and quantum technologies.

  2. An efficient biologically-inspired photocell enhanced by quantum coherence

    E-Print Network [OSTI]

    Creatore, C; Emmott, S; Chin, A W

    2013-01-01

    Artificially reproducing the biological light reactions responsible for the remarkably efficient photon-to-charge conversion in photosynthetic complexes represents a new direction for the future development of photovoltaic devices. Here, we develop such a paradigm and present a model photocell based on the nanoscale architecture of photosynthetic reaction centres that explicitly harnesses the quantum mechanical effects recently discovered in photosynthetic complexes. Quantum interference of photon absorption/emission induced by the dipole-dipole interaction between molecular excited states guarantees an enhanced light-to-current conversion and power generation for a wide range of realistic parameters, opening a promising new route for designing artificial light-harvesting devices inspired by biological photosynthesis and quantum technologies.

  3. Division of Biological and Medical Research annual research summary, 1983

    SciTech Connect (OSTI)

    Barr, S.H. (ed.)

    1984-08-01

    This research summary contains brief descriptions of research in the following areas: (1) mechanisms of hepatocarcinogenesis; (2) role of metals in cocarcinogenesis and the use of liposomes for metal mobilization; (3) control of mutagenesis and cell differentiation in cultured cells by tumor promoters; (4) radiation effects in mammalian cells; (5) radiation carcinogenesis and radioprotectors; (6) life shortening, tumor induction, and tissue dose for fission-neutron and gamma-ray irradiations; (7) mammalian genetics and biostatistics; (8) radiation toxicity studies; (9) hematopoiesis in chronic toxicity; (10) molecular biology studies; (11) chemical toxicology; (12) carcinogen identification and metabolism; (13) metal metabolism and toxicity; and (14) neurobehavioral chronobiology. (ACR)

  4. Method and apparatus to image biological interactions in plants

    DOE Patents [OSTI]

    Weisenberger, Andrew; Bonito, Gregory M.; Reid, Chantal D.; Smith, Mark Frederick

    2015-12-22

    A method to dynamically image the actual translocation of molecular compounds of interest in a plant root, root system, and rhizosphere without disturbing the root or the soil. The technique makes use of radioactive isotopes as tracers to label molecules of interest and to image their distribution in the plant and/or soil. The method allows for the study and imaging of various biological and biochemical interactions in the rhizosphere of a plant, including, but not limited to, mycorrhizal associations in such regions.

  5. Developing Biological Specifications for Fish Friendly Turbines...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Developing Biological Specifications for Fish Friendly Turbines Developing Biological Specifications for Fish Friendly Turbines This factsheet explains studies conducted in a...

  6. The sequestration efficiency of the biological pump

    E-Print Network [OSTI]

    DeVries, Tim; Primeau, Francois; Deutsch, Curtis

    2012-01-01

    Preformed phosphate, soft tissue pump and atmospheric CO 2 ,efficiency of the biological pump Tim DeVries, 1 Francoisproduces a “biological pump” that reduces the concentration

  7. Computational biology and high performance computing

    E-Print Network [OSTI]

    Shoichet, Brian

    2011-01-01

    Biology and High Performance Computing Manfred Zorn, TeresaBiology and High Performance Computing Presenters: Manfred99-Portland High performance computing has become one of the

  8. Chemistry & Biology Deciphering the Late Biosynthetic Steps

    E-Print Network [OSTI]

    Zhao, Huimin

    Chemistry & Biology Article Deciphering the Late Biosynthetic Steps of Antimalarial Compound FR Engineering 2Institute for Genomic Biology 3Department of Microbiology 4Department of Chemistry 5Departments

  9. Renewable Hydrogen Production from Biological Systems

    Broader source: Energy.gov (indexed) [DOE]

    Hydrogen Production from Biological Systems Matthew Posewitz Colorado School of Mines DOE Biological Hydrogen Production Workshop September 24 th , 2013 H 2 production PSIIPSI...

  10. DEPARTMENT OF BIOLOGY Hurricane Savitz Hits Florida

    E-Print Network [OSTI]

    Kelly, John J.

    DEPARTMENT OF BIOLOGY Hurricane Savitz Hits Florida (Photo Credit: Michael Masellis, Biology Major Hurricane Savitz Hits Florida Future Science Teachers' Club Recent Grant Successes Forthcoming Publications

  11. The Molecular Structure of a Phosphatidylserine Bilayer Determined by Scattering and Molecular Dynamics Simulations

    SciTech Connect (OSTI)

    Pan, Jianjun [University of South Florida, Tampa (USF)] [University of South Florida, Tampa (USF); Cheng, Xiaolin [ORNL] [ORNL; Monticelli, Luca [Institut National de la Santé et de la Recherche Médicale (INSERM) and INTS, France] [Institut National de la Santé et de la Recherche Médicale (INSERM) and INTS, France; Heberle, Frederick A [ORNL] [ORNL; Kucerka, Norbert [Atomic Energy of Canada Limited (AECL), Canadian Neutron Beam Centre (CNBC) and Comenius University,] [Atomic Energy of Canada Limited (AECL), Canadian Neutron Beam Centre (CNBC) and Comenius University,; Tieleman, D. Peter [University of Calgary, ALberta, Canada] [University of Calgary, ALberta, Canada; Katsaras, John [ORNL] [ORNL

    2014-01-01

    Phosphatidylserine (PS) lipids play essential roles in biological processes, including enzyme activation and apoptosis. We report on the molecular structure and atomic scale interactions of a fluid bilayer composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylserine (POPS). A scattering density profile model, aided by molecular dynamics (MD) simulations, was developed to jointly refine different contrast small-angle neutron and X-ray scattering data, which yielded a lipid area of 62.7 A2 at 25 C. MD simulations with POPS lipid area constrained at different values were also performed using all-atom and aliphatic united-atom models. The optimal simulated bilayer was obtained using a model-free comparison approach. Examination of the simulated bilayer, which agrees best with the experimental scattering data, reveals a preferential interaction between Na+ ions and the terminal serine and phosphate moieties. Long-range inter-lipid interactions were identified, primarily between the positively charged ammonium, and the negatively charged carboxylic and phosphate oxygens. The area compressibility modulus KA of the POPS bilayer was derived by quantifying lipid area as a function of surface tension from area-constrained MD simulations. It was found that POPS bilayers possess a much larger KA than that of neutral phosphatidylcholine lipid bilayers. We propose that the unique molecular features of POPS bilayers may play an important role in certain physiological functions.

  12. Architecture & Civil Engineering Biology & Biochemistry

    E-Print Network [OSTI]

    Burton, Geoffrey R.

    Department Architecture & Civil Engineering Biology & Biochemistry Chemical Engineering Chemistry Computer Science Economics Education Electronic & Electrical Engineering Department Health Management Mathematical Sciences Mechanical Engineering Natural Sciences (please go to the Info Fair ­ no staff in office

  13. BIOLOGICAL ENGINEERING Program of Study

    E-Print Network [OSTI]

    Thomas, Andrew

    The Master of Science in Biological Engineering prepares students to conduct research involving Professor. Conformation of interfacial species, surface spectroscopies/microscopies, binary polymer Sciences. Composites, coating layer mechanical properties. Barbara J. W. Cole, Ph.D. (Washington, 1986

  14. Synthesizing Law for Synthetic Biology

    E-Print Network [OSTI]

    Torrance, Andrew W.

    2010-01-01

    , metabolic pathways, cells, viruses, and whole organisms rapidly, inexpensively, and easily. Already, a number of institutions have helped synthetic biology achieve considerable success, both in terms of science and public awareness. The BioBricks Foundation...

  15. Preparing for Transfer Biological Engineering

    E-Print Network [OSTI]

    Walter, M.Todd

    Preparing for Transfer Majors: Biological Engineering Chemical Engineering Civil Engineering Computer Science Electrical & Computer Engineering Engineering Physics Environmental Engineering Information Science, Systems, & Technology Materials Science & Engineering Mechanical Engineering Operations

  16. Preparing for Transfer Biological Engineering

    E-Print Network [OSTI]

    Walter, M.Todd

    Preparing for Transfer Majors: Biological Engineering Biomedical Engineering* Chemical Engineering Civil Engineering Computer Science Electrical & Computer Engineering Engineering Physics Environmental Engineering Information Science, Systems, & Technology Materials Science & Engineering Mechanical Engineering

  17. Modular design of biological systems

    E-Print Network [OSTI]

    Norville, Julie Erin, 1980-

    2012-01-01

    The focus of my research is the development of technology for building compound biological systems from simpler pieces. I designed BioScaffold parts, a family of variable regions that can be inserted into a DNA sequence ...

  18. ADVANCEMENT COUNCIL Department of Biology

    E-Print Network [OSTI]

    Chalcraft, David R.

    Institute Mark Philips, B.S. North Carolina Biotechnology Center Francis J. Reilly, Jr. Ph.D. Logistics Management Institute Bobby J. Ward, Ph. D. Retired, CP&L Biologues A Newsletter of the Department of Biology

  19. Synthetic biology and crop engineering

    Broader source: Energy.gov [DOE]

    Breakout Session 2: Frontiers and Horizons Session 2-A: Synthetic Biology and the Promise of Biofuels Jonathan Burbaum, Program Director, Department of Energy, Office of Science, ARPA–E

  20. Fluctuations, Responses and Energetics of Molecular Motors

    E-Print Network [OSTI]

    Takahiro Harada; Shin-ichi Sasa

    2006-10-27

    A novel equality relating the rate of energy dissipation to a degree of violation of the fluctuation-response relation (FRR) in nonequilibrium Langevin systems is described. The FRR is a relation between the correlation function of the fluctuations and the response function of macroscopic variables. Although it has been established that the FRR holds in equilibrium, physical significance of violation of the FRR in nonequilibrium systems has been under debate. Recently, the authors have found that an extent of the FRR violation is related in a simple equality to the rate of energy dissipation into the environment in nonequilibrium Langevin systems. In this paper, we fully explain the FRR, the FRR violation, and the new equality with regard to a Langevin model termed a Brownian motor model, which is considered as a simple model of a biological molecular motor. Furthermore, applications of our result to experimental studies of molecular motors are discussed, and, as an illustration, we predict the value of a new time constant regarding the motion of a KIF1A, which is a kind of single-headed kinesin.

  1. Three Dimensional Molecular Imaging for Lignocellulosic Materials

    SciTech Connect (OSTI)

    Bohn, Paul W.; Sweedler, Jonathan V.

    2011-06-09

    The development of high efficiency, inexpensive processing protocols to render biomass components into fermentable substrates for the sequential processing of cell wall components into fuels and important feedstocks for the biorefinery of the future is a key goal of the national roadmap for renewable energy. Furthermore, the development of such protocols depends critically on detailed knowledge of the spatial and temporal infiltration of reagents designed to remove and separate the phenylpropenoid heteropolymer (lignin) from the processable sugar components sequestered in the rigid cell walls of plants. A detailed chemical and structural understanding of this pre-enzymatic processing in space and time was the focus of this program. We worked to develop new imaging strategies that produce real-time molecular speciation information in situ; extract sub-surface information about the effects of processing; and follow the spatial and temporal characteristics of the molecular species in the matrix and correlate this complex profile with saccharification. Spatially correlated SIMS and Raman imaging were used to provide high quality, high resolution subcellular images of Miscanthus cross sections. Furthermore, the combination of information from the mass spectrometry and Raman scattering allows specific chemical assignments of observed structures, difficult to assign from either imaging approach alone and lays the foundation for subsequent heterocorrelated imaging experiments targeted at more challenging biological systems, such as the interacting plant-microbe systems relevant to the rhizosphere.

  2. The 2011 Dynamics of Molecular Collisions Conference

    SciTech Connect (OSTI)

    Nesbitt, David J.

    2011-07-11

    The Dynamics of Molecular Collisions Conference focuses on all aspects of molecular collisions--experimental & theoretical studies of elastic, inelastic, & reactive encounters involving atoms, molecules, ions, clusters, & surfaces--as well as half collisions--photodissociation, photo-induced reaction, & photodesorption. The scientific program for the meeting in 2011 included exciting advances in both the core & multidisciplinary forefronts of the study of molecular collision processes. Following the format of the 2009 meeting, we also invited sessions in special topics that involve interfacial dynamics, novel emerging spectroscopies, chemical dynamics in atmospheric, combustion & interstellar environments, as well as a session devoted to theoretical & experimental advances in ultracold molecular samples. Researchers working inside & outside the traditional core topics of the meeting are encouraged to join the conference. We invite contributions of work that seeks understanding of how inter & intra-molecular forces determine the dynamics of the phenomena under study. In addition to invited oral sessions & contributed poster sessions, the scientific program included a formal session consisting of five contributed talks selected from the submitted poster abstracts. The DMC has distinguished itself by having the Herschbach Medal Symposium as part of the meeting format. This tradition of the Herschbach Medal was first started in the 2007 meeting chaired by David Chandler, based on a generous donation of funds & artwork design by Professor Dudley Herschbach himself. There are two such awards made, one for experimental & one for theoretical contributions to the field of Molecular Collision Dynamics, broadly defined. The symposium is always held on the last night of the meeting & has the awardees are asked to deliver an invited lecture on their work. The 2011 Herschbach Medal was dedicated to the contributions of two long standing leaders in Chemical Physics, Professor Yuan T. Lee & Professor George Schatz. Professor Lee’s research has been based on the development & use of advanced chemical kinetics & molecular beams to investigate & manipulate the behavior of fundamental chemical reactions. Lee’s work has been recognized by many awards, including the Nobel Prize for Chemistry in 1986, as well as Sloan Fellow, Dreyfus Scholar, Fellowship in the American Academy of Arts & Sciences, Fellowship in the American Physical Society, Guggenheim Fellow, Member National Academy of Sciences, Member Academia Sinica, E.O. Lawrence Award, Miller Professor, Berkeley, Fairchild Distinguished Scholar, Harrison Howe Award, Peter Debye Award, & the National Medal of Science. Lee also has served as the President of the Academia Sinica in Taiwan (ROC). Professor Schatz’s research group is interested in using theory & computation to describe physical phenomena in a broad range of applications relevant to chemistry, physics, biology & engineering. Among the types of applications that we interested are: optical properties of nanoparticles & nanoparticle assemblies; using theory to model polymer properties; DNA structure, thermodynamics & dynamics; modeling self assembly & nanopatterning; & gas phase reaction dynamics. Among his many awards & distinctions have been appointment as an Alfred P. Sloan Research Fellow, Camille & Henry Dreyfus Teacher-Scholar, the Fresenius Award, Fellow of the American Physical Society, the Max Planck Research Award, Fellowship in the American Association for the Advancement of Science, & election to the International Academy of Quantum Molecular Sciences & the American Academy of Arts & Sciences. Dr Schatz is also lauded for his highly successful work as Editor for the Journal of Physical Chemistry. We requested $10,000 from DOE in support of this meeting. The money was distributed widely among the student & post doctoral fellows & some used to attract the very best scientists in the field. The organizers were committed to encouraging women & minorities as well as encourage the field of Chemical Physics in scientific

  3. Completing an Honors Thesis in Microbiology or Molecular What is the Expectation for an Honors Thesis?

    E-Print Network [OSTI]

    Martinez, Tony R.

    Completing an Honors Thesis in Microbiology or Molecular Biology What is the Expectation for an Honors Thesis? Undergraduates in the Honors Program have the opportunity to produce a significant original research work and present it in a formal, written format: the thesis. Often, the work

  4. Statistical Evaluation of a Bottom-Up Clustering for Single Particle Molecular Images

    E-Print Network [OSTI]

    Stephan, Frank

    structures are solved. Under low dose conditions to minimize radiation damage? molecular images are usually i m o n o h a r a ' ~ ~Kiyoshi Asai1 yukio0cbrc.j p asaimcbrc .j p ' Computational Biology Research by bottom-up clustering, a hierarchical algorithm, using simulated protein images with a low signal- to

  5. POLYMER END-GROUP ANALYSIS: THE DETERMINATION OF AVERAGE MOLECULAR WEIGHT

    E-Print Network [OSTI]

    Weston, Ken

    POLYMER END-GROUP ANALYSIS: THE DETERMINATION OF AVERAGE MOLECULAR WEIGHT Background reading. 11. Skoog, West, Holler and Crouch, 7th ed., Chap. 14. Introduction Polymers Polymers are a special in this experiment, or may be of different types. Polymers are very important in biological systems. For example

  6. PHYSICS OF CHEMORECEPTION HOWARD C. BERG AND EDWARD M. PURCELL, Department ofMolecular,

    E-Print Network [OSTI]

    Voigt, Chris

    PHYSICS OF CHEMORECEPTION HOWARD C. BERG AND EDWARD M. PURCELL, Department ofMolecular, Cellular, and Developmental Biology, University ofColorado, Boulder, Colorado 80309 and the Department ofPhysics, Harvard. In these circumstances, what are the physical limitations on the cell's ability to sense and respond to changes in its

  7. Thesis proposal CSF Brazil 2014 Molecular diversity from renewable furan: Toward new MedChem scaffolds

    E-Print Network [OSTI]

    Bordenave, Charles

    Thesis proposal CSF Brazil 2014 Title: Molecular diversity from renewable furan: Toward new Med collaboration in Brazil: Decoration of the different scaffolds synthesized and biological assays (antitumoral-Manguinhos Rua Sizenando Nabuco, 100, Manguinhos 21041-250 - Rio de Janeiro - RJ - Brazil Powered by TCPDF (www

  8. Molecular Dissection of Psoriasis: Integrating Genetics and James T. Elder1,2

    E-Print Network [OSTI]

    Abecasis, Goncalo

    Molecular Dissection of Psoriasis: Integrating Genetics and Biology James T. Elder1,2 , Allen T J. Voorhees1 , Gonc¸alo R. Abecasis3 and Rajan P. Nair1 Psoriasis is a common and debilitating-wide linkage studies of psoriasis focused on segregation of micro- satellite markers in families; however

  9. Predicted decline of protected whales based on molecular genetic monitoring of Japanese

    E-Print Network [OSTI]

    Palumbi, Stephen

    of `whale' products purchased from retail markets in Japan and the Republic of (South) Korea during 1993˘rmed the power of molecular methods in monitoring retail markets and pointed to the inadequacy of the current markets C. S. Baker1* , G. M. Lento1 , F. Cipriano2 and S. R. Palumbi2 1 School of Biological Sciences

  10. Cellular/Molecular Mechanisms of Transport and Exocytosis of Dense-Core

    E-Print Network [OSTI]

    Silverman, Michael

    Cellular/Molecular Mechanisms of Transport and Exocytosis of Dense-Core Granules Containing Tissue of Biological Sciences, California State Polytechnic University, Pomona, California 91768, Departments of 2 microscopy, in conjunction with transport theory, to visualize the transport and exocytosis of DCGs

  11. Molecular Dynamics Simulations: Methods and Value in the Folding Problem Devon Chandler-Brown

    E-Print Network [OSTI]

    March 2013 Introduction The protein folding has been an outstanding problem in molecular biology for a long period of time. Stated simply, the question of protein folding is that of how the primary amino that govern protein folding are thought to be well established. Forces driven by ionic, Van der Waals

  12. Sandia Energy - Molecular Geochemistry

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II)Geothermal Energy &Water Power&Grid ActionModelingMolecular

  13. A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm

    SciTech Connect (OSTI)

    Aderem, Alan; Adkins, Joshua N.; Ansong, Charles; Galagan, James; Kaiser, Shari; Korth, Marcus J.; Law, G. L.; McDermott, Jason E.; Proll, Sean; Rosenberger, Carrie; Schoolnik, Gary; Katze, Michael G.

    2011-02-01

    The 20th century was marked by extraordinary advances in our understanding of microbes and infectious disease, but pandemics remain, food and water borne illnesses are frequent, multi-drug resistant microbes are on the rise, and the needed drugs and vaccines have not been developed. The scientific approaches of the past—including the intense focus on individual genes and proteins typical of molecular biology—have not been sufficient to address these challenges. The first decade of the 21st century has seen remarkable innovations in technology and computational methods. These new tools provide nearly comprehensive views of complex biological systems and can provide a correspondingly deeper understanding of pathogen-host interactions. To take full advantage of these innovations, the National Institute of Allergy and Infectious Diseases recently initiated the Systems Biology Program for Infectious Disease Research. As participants of the Systems Biology Program we think that the time is at hand to redefine the pathogen-host research paradigm.

  14. Assessment of Molecular Modeling & Simulation

    SciTech Connect (OSTI)

    2002-01-03

    This report reviews the development and applications of molecular and materials modeling in Europe and Japan in comparison to those in the United States. Topics covered include computational quantum chemistry, molecular simulations by molecular dynamics and Monte Carlo methods, mesoscale modeling of material domains, molecular-structure/macroscale property correlations like QSARs and QSPRs, and related information technologies like informatics and special-purpose molecular-modeling computers. The panel's findings include the following: The United States leads this field in many scientific areas. However, Canada has particular strengths in DFT methods and homogeneous catalysis; Europe in heterogeneous catalysis, mesoscale, and materials modeling; and Japan in materials modeling and special-purpose computing. Major government-industry initiatives are underway in Europe and Japan, notably in multi-scale materials modeling and in development of chemistry-capable ab-initio molecular dynamics codes.

  15. Cerenkov emission induced by external beam radiation stimulates molecular fluorescence

    SciTech Connect (OSTI)

    Axelsson, Johan; Davis, Scott C.; Gladstone, David J.; Pogue, Brian W.

    2011-07-15

    Purpose: Cerenkov emission is induced when a charged particle moves faster than the speed of light in a given medium. Both x-ray photons and electrons produce optical Cerenkov photons in everyday radiation therapy of tissue; yet, this phenomenon has never been fully documented. This study quantifies the emissions and also demonstrates that the Cerenkov emission can excite a fluorophore, protoporphyrin IX (PpIX), embedded in biological phantoms. Methods: In this study, Cerenkov emission induced by radiation from a clinical linear accelerator is investigated. Biological mimicking phantoms were irradiated with x-ray photons, with energies of 6 or 18 MV, or electrons at energies 6, 9, 12, 15, or 18 MeV. The Cerenkov emission and the induced molecular fluorescence were detected by a camera or a spectrometer equipped with a fiber optic cable. Results: It is shown that both x-ray photons and electrons, at MeV energies, produce optical Cerenkov photons in tissue mimicking media. Furthermore, we demonstrate that the Cerenkov emission can excite a fluorophore, protoporphyrin IX (PpIX), embedded in biological phantoms. Conclusions: The results here indicate that molecular fluorescence monitoring during external beam radiotherapy is possible.

  16. Petri net modelling of biological Claudine Chaouiya

    E-Print Network [OSTI]

    Breitling, Rainer

    Petri net modelling of biological networks Claudine Chaouiya Submitted: 31st March 2007; Received into the functioning of complex biological networks. In this context, Petri nets (PNs) have recently emerged of the computational systems biology. Keywords: dynamical modelling; Petri nets; biological networks INTRODUCTION

  17. Supplemental Graduate Application DEPARTMENT OF BIOLOGY

    E-Print Network [OSTI]

    Hamburger, Peter

    Supplemental Graduate Application DEPARTMENT OF BIOLOGY INDIANA UNIVERSITY-PURDUE UNIVERSITY FORT: ______________________ To assist with processing your application please fill out and submit this form to biology For questions, please refer to the Biology Graduate Programs Handbook or contact the Biology Graduate Program

  18. Biology Advising Office Building 44, Room 135

    E-Print Network [OSTI]

    Clayton, Dale H.

    Biology Advising Office Building 44, Room 135 Mailing Address: Biology Advising Office, University of Utah, 257 South 1400 East, Salt Lake City, Utah 84112-0840 http://www.biology.utah.edu/undergraduate/advising.php Email: advising@biology.utah.edu Phone: (801) 581-6244 Fax: (801) 581-8571 Denise M. Brenis, Director

  19. Plant & Microbial Biology Spring 2012 Seminar Series

    E-Print Network [OSTI]

    Wildermuth, Mary C

    Lovley Department of Microbial Biology | University of Massachusetts, Amherst "Artificial Photosynthesis

  20. Traffic of Molecular Motors

    E-Print Network [OSTI]

    Stefan Klumpp; Melanie J. I. Müller; Reinhard Lipowsky

    2005-12-06

    Molecular motors perform active movements along cytoskeletal filaments and drive the traffic of organelles and other cargo particles in cells. In contrast to the macroscopic traffic of cars, however, the traffic of molecular motors is characterized by a finite walking distance (or run length) after which a motor unbinds from the filament along which it moves. Unbound motors perform Brownian motion in the surrounding aqueous solution until they rebind to a filament. We use variants of driven lattice gas models to describe the interplay of their active movements, the unbound diffusion, and the binding/unbinding dynamics. If the motor concentration is large, motor-motor interactions become important and lead to a variety of cooperative traffic phenomena such as traffic jams on the filaments, boundary-induced phase transitions, and spontaneous symmetry breaking in systems with two species of motors. If the filament is surrounded by a large reservoir of motors, the jam length, i.e., the extension of the traffic jams is of the order of the walking distance. Much longer jams can be found in confined geometries such as tube-like compartments.

  1. Lubricant characterization by molecular simulation

    SciTech Connect (OSTI)

    Moore, J.D.; Cui, S.T.; Cummings, P.T.; Cochran, H.D.

    1997-12-01

    The authors have reported the calculation of the kinematic viscosity index of squalane from nonequilibrium molecular dynamics simulations. This represents the first accurate quantitative prediction of this measure of lubricant performance by molecular simulation. Using the same general alkane potential model, this computational approach offers the possibility of predicting the performance of potential lubricants prior to synthesis. Consequently, molecular simulation is poised to become an important tool for future lubricant development.

  2. Electron Trapping by Molecular Vibration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Electron Trapping by Molecular Vibration Print In photoelectron spectroscopy experiments performed at the ALS, a group of researchers has found that electronic transitions normally...

  3. Interface-assisted molecular spintronics

    SciTech Connect (OSTI)

    Raman, Karthik V.

    2014-09-15

    Molecular spintronics, a field that utilizes the spin state of organic molecules to develop magneto-electronic devices, has shown an enormous scientific activity for more than a decade. But, in the last couple of years, new insights in understanding the fundamental phenomena of molecular interaction on magnetic surfaces, forming a hybrid interface, are presenting a new pathway for developing the subfield of interface-assisted molecular spintronics. The recent exploration of such hybrid interfaces involving carbon based aromatic molecules shows a significant excitement and promise over the previously studied single molecular magnets. In the above new scenario, hybridization of the molecular orbitals with the spin-polarized bands of the surface creates new interface states with unique electronic and magnetic character. This study opens up a molecular-genome initiative in designing new handles to functionalize the spin dependent electronic properties of the hybrid interface to construct spin-functional tailor-made devices. Through this article, we review this subject by presenting a fundamental understanding of the interface spin-chemistry and spin-physics by taking support of advanced computational and spectroscopy tools to investigate molecular spin responses with demonstration of new interface phenomena. Spin-polarized scanning tunneling spectroscopy is favorably considered to be an important tool to investigate these hybrid interfaces with intra-molecular spatial resolution. Finally, by addressing some of the recent findings, we propose novel device schemes towards building interface tailored molecular spintronic devices for applications in sensor, memory, and quantum computing.

  4. Electron Trapping by Molecular Vibration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    types of molecular vibrations. Specifically, they found that when the symmetry of a linear triatomic molecule is broken by asymmetric vibrational modes, photoelectrons can...

  5. Molecular Cell Hydroxyurea Induces Hydroxyl

    E-Print Network [OSTI]

    Collins, James J.

    Molecular Cell Article Hydroxyurea Induces Hydroxyl Radical-Mediated Cell Death in Escherichia coli superoxide production, together with the increased iron uptake, fuels the formation of hydroxyl radicals

  6. Probing Interactions in Complex Molecular Systems through Ordered Assembly

    SciTech Connect (OSTI)

    De Yoreo, J J; Bartelt, M C; Orme, C A; Villacampa, A; Weeks, B L; Miller, A E

    2002-01-31

    Emerging from the machinery of epitaxial science and chemical synthesis, is a growing emphasis on development of self-organized systems of complex molecular species. The nature of self-organization in these systems spans the continuum from simple crystallization of large molecules such as dendrimers and proteins, to assembly into large organized networks of nanometer-scale structures such as quantum dots or nanoparticles. In truth, self-organization in complex molecular systems has always been a central feature of many scientific disciplines including fields as diverse as structural biology, polymer science and geochemistry. But over the past decade, changes in those fields have often been marked by the degree to which researchers are using molecular-scale approaches to understand the hierarchy of structures and processes driven by this ordered assembly. At the same time, physical scientists have begun to use their knowledge of simple atomic and molecular systems to fabricate synthetic self-organized systems. This increasing activity in the field of self-organization is testament to the success of the physical and chemical sciences in building a detailed understanding of crystallization and epitaxy in simple atomic and molecular systems, one that is soundly rooted in thermodynamics and chemical kinetics. One of the fundamental challenges of chemistry and materials science in the coming decades is to develop a similarly well-founded physical understanding of assembly processes in complex molecular systems. Over the past five years, we have successfully used in situ atomic force microscopy (AFM) to investigate the physical controls on single crystal epitaxy from solutions for a wide range of molecular species. More recently, we have combined this method with grazing incidence X-ray diffraction and kinetic Monte Carlo modeling in order to relate morphology to surface atomic structure and processes. The purpose of this proposal was to extend this approach to assemblies of three classes of ''super molecular'' nanostructured materials. These included (1) dendrimers, (2) DNA bonded nano-particles, and (3) colloids, all of which form solution-based self-organizing systems. To this end, our goals were, first, to learn how to modify models of epitaxy in small molecule systems so that they are useful, efficient, and applicable to assembly of super-molecular species; and, second, to learn how systematic variations in the structure and bonding of the building blocks affect the surface kinetics and energetics that control the assembly process and the subsequent dynamic behavior of the assembled structures. AFM imaging provided experimental data on morphology and kinetics, while kinetic Monte Carlo (KMC) simulations related these data to molecular-scale processes and features.

  7. Elliott J Blumenthal-Biology Lead Advisor and Associate Chair-Biology

    E-Print Network [OSTI]

    Hamburger, Peter

    Elliott J Blumenthal- Biology Lead Advisor and Associate Chair- Biology Frank V Paladino- Chair, Department of Biology #12;Objectives for Orientation today To give a description of the Biology Program To give an overview of the various "CONCENTRATIONS" that are available for majors in Biology To describe

  8. Biology BS, Environmental Biology Emphasis, 2015-2016 Name ID# Date

    E-Print Network [OSTI]

    Barrash, Warren

    Biology BS, Environmental Biology Emphasis, 2015-2016 Name ID# Date Course Number and Title Credits 170 4 DLN BIOL 191 General Biology I 4 DLN CHEM 111, 111L General Chemistry I with Lab 4 DLV Visual Sciences course in a second field 3 BIOL 192 General Biology II 4 BIOL 301 Cell Biology 3 CID BIOL 323

  9. 6/06/09 BA in General Biology Bachelor of Arts in General Biology

    E-Print Network [OSTI]

    6/06/09 BA in General Biology Bachelor of Arts in General Biology Department of Biology College of Science and Engineering Undergraduate Programs Students majoring in the General Biology degree program are required to complete 57 units in the major. In addition to the biological science courses, it includes

  10. Biology BS, Human Biology Emphasis, 2015-2016 Name ID# Date

    E-Print Network [OSTI]

    Barrash, Warren

    Biology BS, Human Biology Emphasis, 2015-2016 Name ID# Date Course Number and Title Credits 170 4 DLN BIOL 191 General Biology I 4 DLN CHEM 111, 111L General Chemistry I with Lab 4 DLV Visual Sciences course in a second field 3 BIOL 192 General Biology II 4 BIOL 301 Cell Biology 3 CID BIOL 323

  11. THE JOURNAI. or BIOLOGICAL CHEMISTRY igi 1992 by The American Society for Biochemistry and Molecular Biology, Inc.

    E-Print Network [OSTI]

    Simpson, Larry

    cytochrome 6 mRNA is cleaved at several sites. With time, complete degradation of the RNA occurs. All is inhibited by sodium dodecyl sulfate or phenol/chloroform extraction, is retained by a 10-kDa cutoff filter

  12. Molecular Gas in Elliptical Galaxies

    E-Print Network [OSTI]

    L. M. Young

    2000-09-05

    The distribution and kinematics of the molecular gas in elliptical galaxies give information on the origin and history of the gas and the rate of star formation activity in ellipticals. I describe some preliminary results of a survey which will more than double the number of elliptical galaxies with resolved molecular distributions.

  13. Molecular Motors: A Theorist's Perspective

    E-Print Network [OSTI]

    Molecular Motors: A Theorist's Perspective Anatoly B. Kolomeisky1 and Michael E. Fisher2 1/0505-0675$20.00 Key Words motor proteins, kinesin, myosin, single-molecule experiments, discrete stochastic models Abstract Individual molecular motors, or motor proteins, are enzymatic molecules that convert chemical

  14. Chemical Dynamics, Molecular Energetics, and Kinetics at the Synchrotron

    SciTech Connect (OSTI)

    Leone, Stephen R.; Ahmed, Musahid; Wilson, Kevin R.

    2010-03-14

    Scientists at the Chemical Dynamics Beamline of the Advanced Light Source in Berkeley are continuously reinventing synchrotron investigations of physical chemistry and chemical physics with vacuum ultraviolet light. One of the unique aspects of a synchrotron for chemical physics research is the widely tunable vacuum ultraviolet light that permits threshold ionization of large molecules with minimal fragmentation. This provides novel opportunities to assess molecular energetics and reaction mechanisms, even beyond simple gas phase molecules. In this perspective, significant new directions utilizing the capabilities at the Chemical Dynamics Beamline are presented, along with an outlook for future synchrotron and free electron laser science in chemical dynamics. Among the established and emerging fields of investigations are cluster and biological molecule spectroscopy and structure, combustion flame chemistry mechanisms, radical kinetics and product isomer dynamics, aerosol heterogeneous chemistry, planetary and interstellar chemistry, and secondary neutral ion-beam desorption imaging of biological matter and materials chemistry.

  15. Large-Scale Molecular Dynamics Simulations for Highly Parallel Infrastructures

    E-Print Network [OSTI]

    Pazúriková, Jana

    2014-01-01

    Computational chemistry allows researchers to experiment in sillico: by running a computer simulations of a biological or chemical processes of interest. Molecular dynamics with molecular mechanics model of interactions simulates N-body problem of atoms$-$it computes movements of atoms according to Newtonian physics and empirical descriptions of atomic electrostatic interactions. These simulations require high performance computing resources, as evaluations within each step are computationally demanding and billions of steps are needed to reach interesting timescales. Current methods decompose the spatial domain of the problem and calculate on parallel/distributed infrastructures. Even the methods with the highest strong scaling hit the limit at half a million cores: they are not able to cut the time to result if provided with more processors. At the dawn of exascale computing with massively parallel computational resources, we want to increase the level of parallelism by incorporating parallel-in-time comput...

  16. Chemical and Biological Engineering Department Code 1 Department of Chemical & Biological Engineering

    E-Print Network [OSTI]

    Dandy, David

    Chemical and Biological Engineering Department Code 1 CODE of the Department of Chemical of Chemical & Biological Engineering. For clarity of presentation, some passages are copied directly from shall offer an undergraduate chemical and biological engineering program of technological, scientific

  17. WithCarbonSequestration Biological-

    E-Print Network [OSTI]

    342928Net energy ratio 2.603.303.60$/kg H2Total cost Central Hydrogen from Biomass via Gasification · Techno-Economic Analysis of H2 Production by Gasification of Biomass · Renewables Analysis · BiomassWithCarbonSequestration Biomass Hydro Wind Solar Coal Nuclear Natural Gas Oil Biological

  18. Chemistry & Biology 16 Supplemental Data

    E-Print Network [OSTI]

    Cheng, Jianjun

    Chemistry & Biology 16 Supplemental Data Inorganic Mercury Detection and Controlled Release Cheng, Gerard C. L. Wong, and Yi Lu SUPPLEMENTAL EXPERIMENTAL PROCEDURES Materials The lipids 1, in Eagle's Menimum Essential Medium, supplemented with 100 units/mL aqueous penicillin G, 100 µg

  19. DCC Case Study: Integrative Biology 

    E-Print Network [OSTI]

    Donnelly, Martin; Boyd, Victoria; Spellman, Jill

    2008-04-03

    these illnesses. The main aim of the Integrative Biology (IB) project is to realise this potential by developing multi-scale models - spanning the range from genes to whole organs - and to provide data management features for its disparate users including...

  20. Poverty Grass Biology and Management

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Poverty Grass Biology and Management Hilary Sandler, Katherine Ghantous, and Chelsea Hedderig UMass Cranberry Station, East Wareham, MA 02538 www.umass.edu/cranberry Background In the 1950's, Poverty grass identified as our "poverty grass" and has also been known as broom beardgrass. Little bluestem is often

  1. SYSTEMS BIOLOGY Accurate information transmission

    E-Print Network [OSTI]

    Tsimring, Lev S.

    SYSTEMS BIOLOGY Accurate information transmission through dynamic biochemical signaling networks) and variability in cellular states (extrinsic noise) degrade information transmitted through signaling networks-induced information loss. In the extracellular signal­regulated kinase (ERK), calcium (Ca2+ ), and nuclear factor

  2. Biological Impacts of Climate Change

    E-Print Network [OSTI]

    McCarty, John P.

    Biological Impacts of Climate Change John P McCarty, University of Nebraska at Omaha, Omaha, NE and reproduction depend on how well adapted individuals are to local climate patterns. Climate change can disrupt subsequent impacts on populations or species' distributions across geographic regions. Climate change may

  3. Advanced Topics in Computational Biology

    E-Print Network [OSTI]

    Lonardi, Stefano

    1 Advanced Topics in Computational Biology April 6, 2015 CS260 3D structure of genomes ... the next frontier in genomic is space #12;2 Genome (chromosome) 3D structure · Conformation of chromosomes in nuclei is critical to many cellular processes such as gene regulation, DNA replication, maintenance of genome

  4. *Corresponding author. Department of Biology, University of Crete, P.O. Box 2208, GR-71409 Heraklion, Crete, Greece.

    E-Print Network [OSTI]

    Petratos, Kyriacos

    Heraklion, Crete, Greece. Tel.: #30-81-394455; fax: #30-81-394351. E-mail address: kokkinid@imbb.forth.gr (M of Crete, P.O. Box 2208, GR-71110 Heraklion, Crete, Greece Institute of Molecular Biology and Biotechnology (IMBB), P.O. Box 1527, GR-71110 Heraklion, Crete, Greece Faculty of Pharmaceutical Sciences, Chiba

  5. Transition metal complex-based molecular machines 

    E-Print Network [OSTI]

    Sooksawat, Dhassida

    2015-06-30

    Inspired by the performance and evolutionarily-optimised natural molecular machines that carry out all the essential tasks contributing to the molecular basis of life, chemists aim towards fabricating synthetic molecular ...

  6. Molecular imaging by optically-detected electron spin resonance of nitrogen-vacancies in nanodiamond

    E-Print Network [OSTI]

    Hegyi, Alex

    2012-01-01

    Molecular imaging refers to a class of noninvasive biomedical imaging techniques with the sensitivity and specificity to image biochemical variations in-vivo. An ideal molecular imaging technique visualizes a biochemical target according to a range of criteria, including high spatial and temporal resolution, high contrast relative to non-targeted tissues, depth-independent penetration into tissue, lack of harm to the organism under study, and low cost. Because no existing molecular imaging modality is ideal for all purposes, new imaging approaches are needed. Here we demonstrate a novel molecular imaging approach, called nanodiamond imaging, that uses nanodiamonds containing nitrogen-vacancy (NV) color centers as an imaging agent, and image nanodiamond targets in pieces of chicken breast. Nanodiamonds can be tagged with biologically active molecules so they bind to specific receptors; their distribution can then be quantified in-vivo via optically-detected magnetic resonance of the NVs. In effect, we are demo...

  7. Extended Lagrangian Density Functional Tight-Binding Molecular Dynamics for Molecules and Solids

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Aradi, Bálint; Niklasson, Anders M. N.; Frauenheim, Thomas

    2015-06-26

    A computationally fast quantum mechanical molecular dynamics scheme using an extended Lagrangian density functional tight-binding formulation has been developed and implemented in the DFTB+ electronic structure program package for simulations of solids and molecular systems. The scheme combines the computational speed of self-consistent density functional tight-binding theory with the efficiency and long-term accuracy of extended Lagrangian Born–Oppenheimer molecular dynamics. Furthermore, for systems without self-consistent charge instabilities, only a single diagonalization or construction of the single-particle density matrix is required in each time step. The molecular dynamics simulation scheme can also be applied to a broad range of problems in materialsmore »science, chemistry, and biology.« less

  8. The Science Institutes at Yale's West Campus Energy Sciences Cancer Biology Chemical Biology Microbial Diversity Nanobiology Systems Biology

    E-Print Network [OSTI]

    Microbial Diversity Nanobiology Systems Biology The Energy Sciences Institute at Yale's West Campus #12The Science Institutes at Yale's West Campus Energy Sciences Cancer Biology Chemical Biology;#12;T he need for cheap, abundant energy is among the defining issues of our time. In the twentieth

  9. The Science Institutes at Yale's West Campus Nanobiology Cancer Biology Chemical Biology Energy Sciences Microbial Diversity Systems Biology

    E-Print Network [OSTI]

    The Science Institutes at Yale's West Campus Nanobiology Cancer Biology Chemical Biology Energy Sciences Microbial Diversity Systems Biology The Nanobiology Institute at Yale's West Campus #12;#12;I n energy. The potential for discovery is extraordinary. Yale scientists are exploring a new frontier within

  10. Protein Structure Suggests Role as Molecular Adapter

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Role as Molecular Adapter Print To split and copy DNA during replication, all cellular organisms use a multicomponent molecular machine known as the replisome. An essential...

  11. Understanding diseases at a molecular level

    SciTech Connect (OSTI)

    Rosev, Tatjana K [Los Alamos National Laboratory

    2008-01-01

    A group of scientists at Los Alamos National Laboratory in 2008 successfully pioneered a microscope able to track protein-sized, hard to see particles in three dimensions. The 3D Tracking Microscope, designed and developed by James H. Werner, Guillaume A. Lessard, Nathan Wells and Peter M. Goodwin of LANL's Center for Integrated Nanotechnologies, won a 2008 R&D 100 award. The team's invention is a unique confocal 3D tracking microscope capable of following the motion of nanometer-sized objects, such as individual molecules, quantum dots, organic fluorophores and single green fluorescent proteins as they zoom through three-dimensional space at rates faster than many intracellular transport processes. The 3D tracking microscope can follow the transport of nanometer-sized particles at micrometer per second rates. This enables researchers to follow individual protein, ribonucleic acid (RNA), or deoxyribonucleic acid (DNA) motion throughout the full three-dimensional volume of a cell to discover the path a particular biomolecule takes, the method it employs to get there and the specific proteins it may be interacting with along the way. In addition to applications in molecular spectroscopy and materials research, the 3D tracking microscope is a powerful tool primarily in the fields of cellular biology and biomedical research, Werner said. 'The 3D tracking microscope will advance our understanding of the molecular basis and kinetics of many diseases, such as cancer, diabetes, or muscular dystrophy,' he said. 'We anticipate the microscope will become a valuable weapon in the arsenal of biomedical researchers who are fighting to find cures for cancer, heart disease and other protein or DNA-based diseases.'

  12. Introduction to Accelerated Molecular Dynamics

    SciTech Connect (OSTI)

    Perez, Danny [Los Alamos National Laboratory

    2012-07-10

    Molecular Dynamics is the numerical solution of the equations of motion of a set of atoms, given an interatomic potential V and some boundary and initial conditions. Molecular Dynamics is the largest scale model that gives unbiased dynamics [x(t),p(t)] in full atomistic detail. Molecular Dynamics: is simple; is 'exact' for classical dynamics (with respect to a given V); can be used to compute any (atomistic) thermodynamical or dynamical properties; naturally handles complexity -- the system does the right thing at the right time. The physics derives only from the interatomic potential.

  13. Computational Modelling in Systems and Synthetic Biology

    E-Print Network [OSTI]

    Romero-Campero, Francisco J.

    modules Networks Cells Colonies Systems Biology and Synthetic Biology #12;Stochasticity is important processes. Executable semantics. o Modularity in cellular systems, especially in gene regulatory networks been successfully applied. Monika Heiner, David Gilbert, Robin Donaldson. Petri Nets for Systems

  14. New Mexico State University Department of Biology

    E-Print Network [OSTI]

    Houde, Peter

    1 New Mexico State University Department of Biology Functions and Criteria for Faculty Evaluation of Biology, the College of Arts and Sciences, and New Mexico State University reward and retain faculty

  15. Authentic teaching and learning through synthetic biology

    E-Print Network [OSTI]

    Kuldell, Natalie

    Synthetic biology is an emerging engineering discipline that, if successful, will allow well-characterized biological components to be predictably and reliably built into robust organisms that achieve specific functions. ...

  16. Foundational platform for mammalian synthetic biology

    E-Print Network [OSTI]

    Davidsohn, Noah (Noah Justin)

    2013-01-01

    The emergent field of synthetic biology is different from many other biological engineering efforts, in that its roots, design principles, and forward engineering perspective have been adopted from electrical engineering ...

  17. Quantitative assessment of biological impact using transcriptomic data and mechanistic network models

    SciTech Connect (OSTI)

    Thomson, Ty M. [Selventa, One Alewife Center, Cambridge, MA 02140 (United States); Sewer, Alain, E-mail: Alain.Sewer@pmi.com [Philip Morris International R and D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel (Switzerland); Martin, Florian; Belcastro, Vincenzo [Philip Morris International R and D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel (Switzerland); Frushour, Brian P. [Selventa, One Alewife Center, Cambridge, MA 02140 (United States); Gebel, Stephan [Philip Morris International R and D, Philip Morris Research Laboratories GmbH, Edmund-Rumpler-Strasse 5, 51149 Koeln (Germany); Park, Jennifer [Selventa, One Alewife Center, Cambridge, MA 02140 (United States); Schlage, Walter K. [Philip Morris International R and D, Philip Morris Research Laboratories GmbH, Edmund-Rumpler-Strasse 5, 51149 Koeln (Germany); Talikka, Marja [Philip Morris International R and D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel (Switzerland); Vasilyev, Dmitry M.; Westra, Jurjen W. [Selventa, One Alewife Center, Cambridge, MA 02140 (United States); Hoeng, Julia; Peitsch, Manuel C. [Philip Morris International R and D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel (Switzerland)

    2013-11-01

    Exposure to biologically active substances such as therapeutic drugs or environmental toxicants can impact biological systems at various levels, affecting individual molecules, signaling pathways, and overall cellular processes. The ability to derive mechanistic insights from the resulting system responses requires the integration of experimental measures with a priori knowledge about the system and the interacting molecules therein. We developed a novel systems biology-based methodology that leverages mechanistic network models and transcriptomic data to quantitatively assess the biological impact of exposures to active substances. Hierarchically organized network models were first constructed to provide a coherent framework for investigating the impact of exposures at the molecular, pathway and process levels. We then validated our methodology using novel and previously published experiments. For both in vitro systems with simple exposure and in vivo systems with complex exposures, our methodology was able to recapitulate known biological responses matching expected or measured phenotypes. In addition, the quantitative results were in agreement with experimental endpoint data for many of the mechanistic effects that were assessed, providing further objective confirmation of the approach. We conclude that our methodology evaluates the biological impact of exposures in an objective, systematic, and quantifiable manner, enabling the computation of a systems-wide and pan-mechanistic biological impact measure for a given active substance or mixture. Our results suggest that various fields of human disease research, from drug development to consumer product testing and environmental impact analysis, could benefit from using this methodology. - Highlights: • The impact of biologically active substances is quantified at multiple levels. • The systems-level impact integrates the perturbations of individual networks. • The networks capture the relationships between the biological mechanisms. • Four exposure experiments have been assessed to validate the methodology. • The impact results were consistent with the corresponding phenotypic measures.

  18. SU-E-I-39: Molecular Image Guided Cancer Stem Cells Therapy

    SciTech Connect (OSTI)

    Abdollahi, H

    2014-06-01

    Purpose: Cancer stem cells resistance to radiation is a problematic issue that has caused a big fail in cancer treatment. Methods: As a primary work, molecular imaging can indicate the main mechanisms of radiation resistance of cancer stem cells. By developing and commissioning new probes and nanomolecules and biomarkers, radiation scientist will able to identify the essential pathways of radiation resistance of cancer stem cells. As the second solution, molecular imaging is a best way to find biological target volume and delineate cancer stem cell tissues. In the other hand, by molecular imaging techniques one can image the treatment response in tumor and also in normal tissue. In this issue, the response of cancer stem cells to radiation during therapy course can be imaged, also the main mechanisms of radiation resistance and finding the best radiation modifiers (sensitizers) can be achieved by molecular imaging modalities. In adaptive radiotherapy the molecular imaging plays a vital role to have higher tumor control probability by delivering high radiation doses to cancer stem cells in any time of treatment. The outcome of a feasible treatment is dependent to high cancer stem cells response to radiation and removing all of which, so a good imaging modality can show this issue and preventing of tumor recurrence and metastasis. Results: Our results are dependent to use of molecular imaging as a new modality in the clinic. We propose molecular imaging as a new radiobiological technique to solve radiation therapy problems due to cancer stem cells. Conclusion: Molecular imaging guided cancer stem cell diagnosis and therapy is a new approach in the field of cancer treatment. This new radiobiological imaging technique should be developed in all clinics as a feasible tool that is more biological than physical imaging.

  19. At the Biological Modeling and Simulation Frontier

    E-Print Network [OSTI]

    2009-01-01

    methods (Boolean networks, Petri nets (27), pi- calculi,C. Petri net modelling of biological networks. Brief

  20. Biology and the Foundation of Ethics

    E-Print Network [OSTI]

    McShea, Daniel W.

    . Evolutionary ethics. Biology and Philosophy 1: 325-35. Van Ingen, J. 1994. Why Be Moral? New York: Peter Lang

  1. Module Identification for Biological Networks 

    E-Print Network [OSTI]

    Wang, Yijie

    2015-08-12

    into the Deoxyri- bonucleic acid (DNA), which is a molecule that stores the genetic instructions used in all biological processes of all known living organisms. Human Genome Project (HGP) has achieved tremendous success in determining the DNA sequence and rec...- ognizing and mapping genes of the human genome based on both their physical and functional responsibilities. However, HGP collaborated all research pioneers around the world and still costed 13 years and $3 billions, which illustrates how difficult...

  2. Autonomous observations of the ocean biological carbon pump

    E-Print Network [OSTI]

    Bishop, James K.B.

    2009-01-01

    efficiency of biological pump in the global ocean. JournalOcean Biological Carbon Pump Carbon Flux Explorerocean’s “biological carbon pump” (Broecker and Peng, 1982;

  3. Lex Genetica: The Law and Ethics of Programming Biological Code

    E-Print Network [OSTI]

    Burk, DL

    2015-01-01

    The law and ethics of programming biological code Dan L.biological artifacts. Such programming may include usagerelated to biological programming, the latter technology

  4. Booly : a new data integration platform for systems biology

    E-Print Network [OSTI]

    Do, Long Hoang

    2010-01-01

    for enabling conceptual biology. Bioinformatics 2005, 21for data integration in biology. Trends Biotechnol 1999, 17(the unification of biology. The Gene Ontology Consortium.

  5. Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Boundary Analysis of Biological Pathways to Hydrogen Production Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen Production Report documenting the biological and...

  6. Evolution of biological complexity Christoph Adami*

    E-Print Network [OSTI]

    Ofria, Charles A.

    Evolution of biological complexity Christoph Adami* , Charles Ofria§ , and Travis C. Collier, Pasadena, CA 91125; and ¶Division of Organismic Biology, Ecology, and Evolution, University of California in the evolution of complexity in biological evolution, complexity needs to be both rigorously defined

  7. Chemical and Biological Engineering Summary of Actions

    E-Print Network [OSTI]

    Maxwell, Bruce D.

    Chemical and Biological Engineering Summary of Actions 2014-2015 Concern Recommendation Action Follow-up 1. The department name is Chemical and Biological Engineering. An analysis of student Biological Engineering programs. 4. The second semester of the senior capstone sequence in Chemical

  8. REVIEW ARTICLE Profile likelihood in systems biology

    E-Print Network [OSTI]

    Timmer, Jens

    REVIEW ARTICLE Profile likelihood in systems biology Clemens Kreutz1,2 , Andreas Raue1,3 , Daniel for Advanced Studies (FRIAS), University of Freiburg, Germany 3 Institute of Bioinformatics and Systems Biology of Freiburg, Germany 5 BIOSS Centre for Biological Signalling Studies, University of Freiburg, Germany

  9. Synthetic Biology for Therapeutic Applications Zhanar Abil,

    E-Print Network [OSTI]

    Zhao, Huimin

    Synthetic Biology for Therapeutic Applications Zhanar Abil, Xiong Xiong, and Huimin Zhao of Bioengineering, Department of Chemistry, Center for Biophysics and Computational Biology and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois

  10. Petra Anne Levin Department of Biology

    E-Print Network [OSTI]

    Petra Anne Levin Department of Biology Campus Box 1137 Washington University St. Louis, MO 63130 Fellow Massachusetts Institute of Technology, Department of Biology Advisor: Dr. Alan Grossman 1996 Ph.D., Biology Harvard University, Cambridge, MA Dissertation: Asymmetric Division During Spore Formation

  11. A CONSTRAINED OBJECT APPROACH TO SYSTEMS BIOLOGY

    E-Print Network [OSTI]

    Krovi, Venkat

    A CONSTRAINED OBJECT APPROACH TO SYSTEMS BIOLOGY by Manu Pushpendran September 2006 A thesis towards Dr. Daniel Fischer for allowing me to audit his course on Computational Biology which helped me gain significant insights on many biological terms. Special thanks to Dr. Gokul Das from Roswell Park

  12. The Division of Biology & Biomedical Sciences

    E-Print Network [OSTI]

    Gereau, Robert W. IV

    The Division of Biology & Biomedical Sciences what will YOU discover? #12;620students more than 470faculty 36departments 12programs and one YOU. DBBS Division of Biology and Biomedical Sciences Washington. The Division of Biology and Biomedical Sciences (DBBS) is ideally positioned to foster the interdisciplinary

  13. Apparatus for molecular weight separation

    DOE Patents [OSTI]

    Smith, Richard D. (Richland, WA); Liu, Chuanliang (Haverhill, MA)

    2001-01-01

    The present invention relates generally to an apparatus and method for separating high molecular weight molecules from low molecular weight molecules. More specifically, the invention relates to the use of microdialysis for removal of the salt (low molecular weight molecules) from a nucleotide sample (high molecular weight molecules) for ESI-MS analysis. The dialysis or separation performance of the present invention is improved by (1) increasing dialysis temperature thereby increasing desalting efficiency and improving spectrum quality; (2) adding piperidine and imidazole to the dialysis buffer solution and reducing charge states and further increasing detection sensitivity for DNA; (3) using low concentrations (0-2.5 mM NH4OAc) of dialysis buffer and shifting the DNA negative ions to higher charge states, producing a nearly 10-fold increase in detection sensitivity and a slightly decreased desalting efficiency, (4) conducting a two-stage separation or (5) any combination of (1), (2), (3) and (4).

  14. Molecular biomechanics of collagen molecules

    E-Print Network [OSTI]

    Chang, Shu-Wei

    Collagenous tissues, made of collagen molecules, such as tendon and bone, are intriguing materials that have the ability to respond to mechanical forces by altering their structures from the molecular level up, and convert ...

  15. Quantum logic with molecular ions

    E-Print Network [OSTI]

    Wolf, Fabian; Heip, Jan C; Gebert, Florian; Shi, Chunyan; Schmidt, Piet O

    2015-01-01

    Laser spectroscopy of cold and trapped molecular ions is a powerful tool for fundamental physics, including the determination of fundamental constants, the laboratory test for their possible variation, and the search for a possible electric dipole moment of the electron. Optical clocks based on molecular ions sensitive to some of these effects are expected to achieve uncertainties approaching the $10^{-18}$ level. While the complexity of molecular structure facilitates these applications, the absence of cycling transitions poses a challenge for direct laser cooling, quantum state control, and detection. Previously employed state detection techniques based on photo-dissociation or chemical reactions are destructive and therefore inefficient. Here we experimentally demonstrate non-destructive state detection of a single trapped molecular ion through its strong Coulomb coupling to a well-controlled co-trapped atomic ion. An algorithm based on a state-dependent optical dipole force(ODF) changes the internal state...

  16. Roadmap: Biology Organismal Biology Bachelor of Science [AS-BS-BSCI-ORBI

    E-Print Network [OSTI]

    Sheridan, Scott

    Roadmap: Biology ­ Organismal Biology ­ Bachelor of Science [AS-BS-BSCI-ORBI] College of Arts/LNHD This roadmap is a recommended semester-by-semester plan of study for this major. However, courses General Elective 3 #12;Roadmap: Biology ­ Organismal Biology ­ Bachelor of Science [AS

  17. Symbolic Systems Biology: Theory and Methods, Jones and Bartlett Publishers 2010 On Statecharts for Biology

    E-Print Network [OSTI]

    Harel, David

    Symbolic Systems Biology: Theory and Methods, Jones and Bartlett Publishers 2010 On Statecharts for Biology Jasmin Fisher and David Harel Biology as Reactivity One of the central issues in software decade or so, we and others have carried out work on viewing biological systems as reactive systems

  18. REQUIREMENTS FOR MINOR IN FISHERY BIOLOGY DEPARTMENT OF FISH, WILDLIFE, AND CONSERVATION BIOLOGY

    E-Print Network [OSTI]

    REQUIREMENTS FOR MINOR IN FISHERY BIOLOGY DEPARTMENT OF FISH, WILDLIFE, AND CONSERVATION BIOLOGY for minor= 26 - 28 Aquatic and Fishery Electives for Fishery Biology Minor (Additional course work may 301/307, MATH 141/155/160) BZ 332 Phycology (F) FW 402 Fish Culture (S; FW 300) BZ 471 Stream Biology

  19. Approaches to Biology Teaching and Learning Cultural Competence in the College Biology Classroom

    E-Print Network [OSTI]

    Feature Approaches to Biology Teaching and Learning Cultural Competence in the College Biology Classroom Kimberly Tanner* and Deborah Allen *Department of Biology, San Francisco State University, San Francisco, CA 94132; and Department of Biological Sciences, University of Delaware, Newark, DE 19716

  20. Approaches to Biology Teaching and Learning Making Biology Learning Relevant to Students: Integrating

    E-Print Network [OSTI]

    Feature Approaches to Biology Teaching and Learning Making Biology Learning Relevant to Students: Integrating People, History, and Context into College Biology Teaching Katayoun Chamany,*Deborah Allen College, The New School for Liberal Arts, New York, NY 10011; Department of Biological Sciences

  1. A First Attempt to Bring Computational Biology into Advanced High School Biology Classrooms

    E-Print Network [OSTI]

    Goldberg, Debra S.

    Education A First Attempt to Bring Computational Biology into Advanced High School Biology Department of Computer Science, University of Colorado, Boulder, Colorado, United States of America, 2Boulder of a computational ele- ment in secondary biology classrooms is of growing concern to the computational biology

  2. MSc Marine Biology Module description (A) MODULE A: FUNDAMENTALS OF MARINE BIOLOGY AND ECOLOGY

    E-Print Network [OSTI]

    Diekmann, Martin

    1 MSc Marine Biology ­ Module description (A) MODULE A: FUNDAMENTALS OF MARINE BIOLOGY AND ECOLOGY (OBLIGATORY COURSES) A1. Principles of Marine Biology and Biological Oceanography (5 CP) A2. Principles of Marine Ecophysiology (5 CP) A3. Experimental Design and Data Analysis (5 CP) TIMING AND DURATION

  3. Stem cell biology is population biology: differentiation of hematopoietic multipotent progenitors to common lymphoid and myeloid progenitors

    E-Print Network [OSTI]

    Mangel, Marc; Bonsall, Michael B

    2013-01-01

    M: Hematopoietic Stem Cell Biology. New York: Humana Press;In Hematopoietic Stem Cell Biology. Edited by Kondo M. Newmodels in stem cell biology: replacement, quiescence, and

  4. Division of Biological and Medical Research research summary 1984-1985

    SciTech Connect (OSTI)

    Barr, S.H. (ed.)

    1985-08-01

    The Division of Biological and Medical Research at Argonne National Laboratory conducts multidisciplinary research aimed at defining the biological and medical hazards to man from energy technologies and new energy options. These technically oriented studies have a strong base in fundamental research in a variety of scientific disciplines, including molecular and cellular biology, biophysics, genetics, radiobiology, pharmacology, biochemistry, chemistry, environmental toxicology, and epidemiology. This research summary is organized into six parts. The first five parts reflect the Divisional structure and contain the scientific program chapters, which summarize the activities of the individual groups during the calendar year 1984 and the first half of 1985. To provide better continuity and perspective, previous work is sometimes briefly described. Although the summaries are short, efforts have been made to indicate the range of research activities for each group.

  5. Final report for Conference Support Grant "From Computational Biophysics to Systems Biology - CBSB12"

    SciTech Connect (OSTI)

    Hansmann, Ulrich H.E.

    2012-07-02

    This report summarizes the outcome of the international workshop �From Computational Biophysics to Systems Biology (CBSB12)� which was held June 3-5, 2012, at the University of Tennessee Conference Center in Knoxville, TN, and supported by DOE through the Conference Support Grant 120174. The purpose of CBSB12 was to provide a forum for the interaction between a data-mining interested systems biology community and a simulation and first-principle oriented computational biophysics/biochemistry community. CBSB12 was the sixth in a series of workshops of the same name organized in recent years, and the second that has been held in the USA. As in previous years, it gave researchers from physics, biology, and computer science an opportunity to acquaint each other with current trends in computational biophysics and systems biology, to explore venues of cooperation, and to establish together a detailed understanding of cells at a molecular level. The conference grant of $10,000 was used to cover registration fees and provide travel fellowships to selected students and postdoctoral scientists. By educating graduate students and providing a forum for young scientists to perform research into the working of cells at a molecular level, the workshop adds to DOE's mission of paving the way to exploit the abilities of living systems to capture, store and utilize energy.

  6. Molecular motors: design, mechanism and control

    E-Print Network [OSTI]

    Debashish Chowdhury

    2008-01-10

    Biological functions in each animal cell depend on coordinated operations of a wide variety of molecular motors. Some of the these motors transport cargo to their respective destinations whereas some others are mobile workshops which synthesize macromolecules while moving on their tracks. Some other motors are designed to function as packers and movers. All these motors require input energy for performing their mechanical works and operate under conditions far from thermodynamic equilibrium. The typical size of these motors and the forces they generate are of the order of nano-meters and pico-Newtons, respectively. They are subjected to random bombardments by the molecules of the surrounding aqueous medium and, therefore, follow noisy trajectories. Because of their small inertia, their movements in the viscous intracellular space exhibits features that are characteristics of hydrodynamics at low Reynold's number. In this article we discuss how theoretical modeling and computer simulations of these machines by physicists are providing insight into their mechanisms which engineers can exploit to design and control artificial nano-motors.

  7. Method of measurement in biological systems

    DOE Patents [OSTI]

    Turteltaub, K.W.; Vogel, J.S.; Felton, J.S.; Gledhill, B.L.: Davis, J.C.; Stanker, L.H.

    1993-05-11

    A method is disclosed of quantifying molecules in biological substances, comprising: selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere; preparing a long-lived radioisotope labeled reactive chemical specie; administering the chemical specie to the biological host in doses sufficiently low to avoid significant overt damage to the biological system; allowing a period of time to elapse sufficient for dissemination and interaction of the chemical specie with the host throughout the biological system of the host; isolating a reacted fraction of the biological substance from the host in a manner sufficient to avoid contamination of the substance from extraneous sources; converting the fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation; and measuring the radioisotope concentration in the material by means of direct isotopic counting.

  8. Experimental, statistical, and biological models of radon carcinogenesis

    SciTech Connect (OSTI)

    Cross, F.T.

    1991-09-01

    Risk models developed for underground miners have not been consistently validated in studies of populations exposed to indoor radon. Imprecision in risk estimates results principally from differences between exposures in mines as compared to domestic environments and from uncertainties about the interaction between cigarette-smoking and exposure to radon decay products. Uncertainties in extrapolating miner data to domestic exposures can be reduced by means of a broad-based health effects research program that addresses the interrelated issues of exposure, respiratory tract dose, carcinogenesis (molecular/cellular and animal studies, plus developing biological and statistical models), and the relationship of radon to smoking and other copollutant exposures. This article reviews experimental animal data on radon carcinogenesis observed primarily in rats at Pacific Northwest Laboratory. Recent experimental and mechanistic carcinogenesis models of exposures to radon, uranium ore dust, and cigarette smoke are presented with statistical analyses of animal data. 20 refs., 1 fig.

  9. Systems biology of Microbial Communities

    SciTech Connect (OSTI)

    Navid, A; Ghim, C; Fenley, A; Yoon, S; Lee, S; Almaas, E

    2008-04-11

    Microbes exist naturally in a wide range of environments, spanning the extremes of high acidity and high temperature to soil and the ocean, in communities where their interactions are significant. We present a practical discussion of three different approaches for modeling microbial communities: rate equations, individual-based modeling, and population dynamics. We illustrate the approaches with detailed examples. Each approach is best fit to different levels of system representation, and they have different needs for detailed biological input. Thus, this set of approaches is able to address the operation and function of microbial communities on a wide range of organizational levels.

  10. Semiconductor Nanocrystals for Biological Imaging

    SciTech Connect (OSTI)

    Fu, Aihua; Gu, Weiwei; Larabell, Carolyn; Alivisatos, A. Paul

    2005-06-28

    Conventional organic fluorophores suffer from poor photo stability, narrow absorption spectra and broad emission feature. Semiconductor nanocrystals, on the other hand, are highly photo-stable with broad absorption spectra and narrow size-tunable emission spectra. Recent advances in the synthesis of these materials have resulted in bright, sensitive, extremely photo-stable and biocompatible semiconductor fluorophores. Commercial availability facilitates their application in a variety of unprecedented biological experiments, including multiplexed cellular imaging, long-term in vitro and in vivo labeling, deep tissue structure mapping and single particle investigation of dynamic cellular processes. Semiconductor nanocrystals are one of the first examples of nanotechnology enabling a new class of biomedical applications.

  11. Biological Safety | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p a l De p uBUSEnergy||slideshow explains theVersatileBiological

  12. Ab-Initio Molecular Dynamics

    E-Print Network [OSTI]

    Thomas D. Kühne

    2013-03-26

    Computer simulation methods, such as Monte Carlo or Molecular Dynamics, are very powerful computational techniques that provide detailed and essentially exact information on classical many-body problems. With the advent of ab-initio molecular dynamics, where the forces are computed on-the-fly by accurate electronic structure calculations, the scope of either method has been greatly extended. This new approach, which unifies Newton's and Schr\\"odinger's equations, allows for complex simulations without relying on any adjustable parameter. This review is intended to outline the basic principles as well as a survey of the field. Beginning with the derivation of Born-Oppenheimer molecular dynamics, the Car-Parrinello method and the recently devised efficient and accurate Car-Parrinello-like approach to Born-Oppenheimer molecular dynamics, which unifies best of both schemes are discussed. The predictive power of this novel second-generation Car-Parrinello approach is demonstrated by a series of applications ranging from liquid metals, to semiconductors and water. This development allows for ab-initio molecular dynamics simulations on much larger length and time scales than previously thought feasible.

  13. Rapid classification of biological components

    DOE Patents [OSTI]

    Thompson, Vicki S. (Idaho Falls, ID); Barrett, Karen B. (Meridian, ID); Key, Diane E. (Idaho Falls, ID)

    2010-03-23

    A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, Cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens of the surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do not form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to a subject's identity.

  14. Rapid classification of biological components

    DOE Patents [OSTI]

    Thompson, Vicki S.; Barrett, Karen B.; Key, Diane E.

    2006-01-24

    A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, cocaine, methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens to the surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to the subject's identity.

  15. Rapid classification of biological components

    DOE Patents [OSTI]

    Thompson, Vicki S. (Idaho Falls, ID); Barrett, Karen B. (Meridian, ID); Key, Diane E. (Idaho Falls, ID)

    2010-03-23

    A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens to a surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do not form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to a subject's identity.

  16. Ab-Initio Molecular Dynamics

    E-Print Network [OSTI]

    Kühne, Thomas D

    2012-01-01

    Computer simulations and molecular dynamics in particular, is a very powerful method to provide detailed and essentially exact informations of classical many-body problems. With the advent of \\textit{ab-initio} molecular dynamics, where the forces are computed on-the-fly by accurate electronic structure calculations, the scope of either method has been greatly extended. This new approach, which unifies Newton's and Schr\\"odinger's equations, allows for complex simulations without relying on any adjustable parameter. This review is intended to outline the basic principles as well as a survey of the field. Beginning with the derivation of Born-Oppenheimer molecular dynamics, the Car-Parrinello method as well as novel hybrid scheme that unifies best of either approach are discussed. The predictive power is demonstrated by a series of applications ranging from insulators to semiconductors and even metals in condensed phases.

  17. Molecular separation method and apparatus

    DOE Patents [OSTI]

    Villa-Aleman, Eliel (3108 Roses Run, Aiken, SC 29803)

    1996-01-01

    A method and apparatus for separating a gaseous mixture of chemically identical but physically different molecules based on their polarities. The gaseous mixture of molecules is introduced in discrete quantities into the proximal end of a porous glass molecular. The molecular sieve is exposed to microwaves to excite the molecules to a higher energy state from a lower energy state, those having a higher dipole moment being excited more than those with a lower energy state. The temperature of the sieve kept cold by a flow of liquid nitrogen through a cooling jacket so that the heat generated by the molecules colliding with the material is transferred away from the material. The molecules thus alternate between a higher energy state and a lower one, with the portion of molecules having the higher dipole moment favored over the others. The former portion can then be extracted separately from the distal end of the molecular sieve.

  18. Molecular Perspectives on the Origins of Chibchan Populations from the Sierra Nevada de Santa Marta, Colombia

    E-Print Network [OSTI]

    Melton, Phillip Edward

    2004-11-01

    of Kansas Central American Theses and Dissertations Collection Molecular Perspectives on the Origins of Chibchan Populations from the Sierra Nevada de Santa Marta, Colombia Professor in Charge Michael H. Crawford Committee Members James H. Mielke Deborah... of the requirements for the degree of Master of Arts ^/DL Mchael/ft Crawford, Chair Dr. James H, Mielke Date Defended: lího/ú^ Abstract Current archaeological, biological and linguistic evidence points to a lower Central American origin for Chibchan speaking...

  19. Division of Biological and Medical Research annual technical report, 1981

    SciTech Connect (OSTI)

    Rosenthal, M.W. (ed.)

    1982-06-01

    This report summarizes research during 1981 in the Division of Biological and Medical Research, Argonne National Laboratory. Studies in Low Level Radiation include comparison of lifetime effects in mice of low level neutron and gamma irradiation, delineation of the responses of dogs to continuous low level gamma irradiation, elucidation of mechanisms of radiation damage and repair in mammalian cells, and study of the genetic effects of high LET radiations. Carcinogenesis research addresses mechanisms of tumor initiation and promotion in rat liver, chemical carcinogenesis in cultured mammalian cells, and molecular and genetic mechanisms of chemical and ultraviolet mutagenesis in bacteria. Research in Toxicology uses a variety of cellular, whole animal, and chronobiological end points, chemical separations, and statistical models to evaluate the hazards and mechanisms of actions of metals, coal gasification by products, and other energy-related pollutants. Human Protein Index studies develop two-dimensional electrophoresis systems for diagnosis and detection of cancer and other disease. Biophysics research includes fundamental structural and biophysical investigations of immunoglobulins and key biological molecules using NMR, crystallographic, and x-ray and neutron small-angle scattering techniques. The final sections cover support facilities, educational activities, seminars, staff talks, staff, and funding agencies.

  20. A national facility for biological cryo-electron microscopy

    SciTech Connect (OSTI)

    Saibil, Helen R.; Grünewald, Kay; Stuart, David I.

    2015-01-01

    This review provides a brief update on the use of cryo-electron microscopy for integrated structural biology, along with an overview of the plans for the UK national facility for electron microscopy being built at the Diamond synchrotron. Three-dimensional electron microscopy is an enormously powerful tool for structural biologists. It is now able to provide an understanding of the molecular machinery of cells, disease processes and the actions of pathogenic organisms from atomic detail through to the cellular context. However, cutting-edge research in this field requires very substantial resources for equipment, infrastructure and expertise. Here, a brief overview is provided of the plans for a UK national three-dimensional electron-microscopy facility for integrated structural biology to enable internationally leading research on the machinery of life. State-of-the-art equipment operated with expert support will be provided, optimized for both atomic-level single-particle analysis of purified macromolecules and complexes and for tomography of cell sections. The access to and organization of the facility will be modelled on the highly successful macromolecular crystallography (MX) synchrotron beamlines, and will be embedded at the Diamond Light Source, facilitating the development of user-friendly workflows providing near-real-time experimental feedback.

  1. Research in thermal biology: Burning questions for coldwater stream fishes

    SciTech Connect (OSTI)

    McCullough, Dr. Dale [University of California, Berkeley; Bartholow, Dr. John [U.S. Department of Fish and Wildlife; Jager, Yetta [ORNL; al., et. [Various Institutes

    2009-01-01

    With the increasing appreciation of global warming impacts on ecological systems in addition to the myriad of land management effects on water quality, the number of literature citations dealing with the effects of water temperature on freshwater fish has escalated in the past decade. Given the many biological scales at which water temperature effects have been studied and the growing need to integrate knowledge from multiple disciplines of thermal biology to fully protect beneficial uses, we held that a survey of the most promising recent developments and an expression of some of the remaining unanswered questions with significant management implications would best be approached collectively by a diverse research community. We have identified five specific topic areas of renewed research where new techniques and critical thought could benefit coldwater stream fishes (particularly salmonids): molecular, organism, population/species, community and ecosystem, and policy issues in water quality. Our hope is that information gained through examination of recent research fronts linking knowledge at various scales will prove useful in managing water quality at a basin level to protect fish populations and whole ecosystems. Standards of the past were based largely on incipient lethal and optimum growth rate temperatures for fish species, while future standards should consider all integrated thermal impacts to the organism and ecosystem.

  2. Method for photo-altering a biological system to improve biological effect

    DOE Patents [OSTI]

    Hill, Richard A. (Irvine, CA); Doiron, Daniel R. (Santa Ynez, CA); Crean, David H. (Santa Barbara, CA)

    2000-08-01

    Photodynamic therapy is a new adjunctive therapy for filtration surgery that does not use chemotherapy agents or radiation, but uses pharmacologically-active sensitizing compounds to produce a titratable, localized, transient, post operative avascular conjunctiva. A photosensitizing agent in a biological system is selectively activated by delivering the photosensitive agent to the biological system and laser activating only a spatially selected portion of the delivered photosensitive agent. The activated portion of the photosensitive agent reacts with the biological system to obtain a predetermined biological effect. As a result, an improved spatial disposition and effectuation of the biological effect by the photosensitive agent in the biological system is achieved.

  3. All-Optical Molecular Orientation

    SciTech Connect (OSTI)

    Oda, Keita; Hita, Masafumi; Minemoto, Shinichirou; Sakai, Hirofumi [Department of Physics, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)

    2010-05-28

    We report clear evidence of all-optical orientation of carbonyl sulfide molecules with an intense nonresonant two-color laser field in the adiabatic regime. The technique relies on the combined effects of anisotropic hyperpolarizability interaction and anisotropic polarizability interaction and does not rely on the permanent dipole interaction with an electrostatic field. It is demonstrated that the molecular orientation can be controlled simply by changing the relative phase between the two wavelength fields. The present technique brings researchers a new steering tool of gaseous molecules and will be quite useful in various fields such as electronic stereodynamics in molecules and ultrafast molecular imaging.

  4. Matrix Effects in Biological Mass Spectrometry Imaging: Identification and Compensation

    SciTech Connect (OSTI)

    Lanekoff, Ingela T.; Stevens, Susan; Stenzel-Poore, Mary; Laskin, Julia

    2014-07-21

    Matrix effects in mass spectrometry imaging (MSI) may affect the observed molecular distribution in chemical and biological systems. In this study, we introduce an experimental approach that efficiently compensates for matrix effects in nanospray desorption electrospray ionization (nano-DESI) MSI without introducing any complexity into the experimental protocol. We demonstrate compensation for matrix effects in nano-DESI MSI of phosphatidylcholine (PC) in normal and ischemic mouse brain tissue by doping the nano-DESI solvent with PC standards. Specifically, we use mouse brain tissue of a middle cerebral artery occlusion (MCAO) stroke model with an ischemic region localized to one hemisphere of the brain. Due to similar suppression in ionization of endogenous PC molecules extracted from the tissue and PC standards added to the solvent, matrix effects are eliminated by normalizing the intensity of the sodium and potassium adducts of endogenous PC to the intensity of the corresponding adduct of the PC standard. This approach efficiently compensates for signal variations resulting from differences in the local concentrations of sodium and potassium in tissue sections and from the complexity of the extracted analyte mixture derived from local variations in molecular composition.

  5. MOLECULAR ENTOMOLOGY Molecular Identification Key for Pest Species of Scirtothrips

    E-Print Network [OSTI]

    Hoddle, Mark S.

    primers and determining the size of the products by using standard agarose gel electrophoresis, followed, Neohydatothrips, molecular identiŢcation key, exotic pests, nondestruc- tive DNA extraction The genus Scirtothrips, several species of Scirtothrips have (or have the potential to) spread from their natural habitats

  6. Electrostatic thin film chemical and biological sensor

    DOE Patents [OSTI]

    Prelas, Mark A. (Columbia, MO); Ghosh, Tushar K. (Columbia, MO); Tompson, Jr., Robert V. (Columbia, MO); Viswanath, Dabir (Columbia, MO); Loyalka, Sudarshan K. (Columbia, MO)

    2010-01-19

    A chemical and biological agent sensor includes an electrostatic thin film supported by a substrate. The film includes an electrostatic charged surface to attract predetermined biological and chemical agents of interest. A charge collector associated with said electrostatic thin film collects charge associated with surface defects in the electrostatic film induced by the predetermined biological and chemical agents of interest. A preferred sensing system includes a charge based deep level transient spectroscopy system to read out charges from the film and match responses to data sets regarding the agents of interest. A method for sensing biological and chemical agents includes providing a thin sensing film having a predetermined electrostatic charge. The film is exposed to an environment suspected of containing the biological and chemical agents. Quantum surface effects on the film are measured. Biological and/or chemical agents can be detected, identified and quantified based on the measured quantum surface effects.

  7. On Biology as an Emergent Science

    E-Print Network [OSTI]

    H. Pierre Noyes

    2007-05-31

    Biology is considered here as an "emergent science" in the sense of Anderson and of Laughlin and Pines. It is demonstrated that a straightforward mathematical definition of "biological system" is useful in showing how biology differs in structure from the lower levels in Anderson's "More is Different" hierarchy. Using cells in a chemostat as a paradigmatic exemplar of a biological system, it is found that a coherent collection of metabolic pathways through a single cell in the chemostat also satisfies the proposed definition of a biological system. This provides a theoretical and mathematical underpinning for Young's fundamental model of biological organization and integration. Evidence for the therapeutic efficacy of Young's method of analysis is provided by preliminary results of clinical trials of a specific application of Young's model to the treatment of cancer cachexia.

  8. Video Article Atmospheric-pressure Molecular Imaging of Biological Tissues and Biofilms by

    E-Print Network [OSTI]

    Vertes, Akos

    and focusing as well as additional sample holders, cooling components, translation stages, and a solvent the imaging performance in LAESI experiments.1 5. If needed, use a room dehumidifier or place the

  9. Molecular Imaging Approaches to Understanding the Roles of Hydrogen Peroxide Biology in Stress and Development

    E-Print Network [OSTI]

    Dickinson, Bryan Craig

    2010-01-01

    The deprotected, phenol form of PYME has one major visibleDPBS and incubated with 5 µM PYME in DPBS for 15 minutes atfluorescence. The mean PYME fluorescence of mRFP-positives

  10. Copyright 2006 C.M.B. Edition Cellular and Molecular Biology TM

    E-Print Network [OSTI]

    Petkov, Nicolai

    , 9700 AV Groningen, The Netherlands Abstract ­ We propose a method for the classification of boar sperm to choose an optimal value of a decision criterion for single cell classification in such a way : image analysis, classification, sperm heads, boar semen, intracellular intensity distribution

  11. Remaining mysteries of Molecular Biology: The role of polyamine metabolites in the cell

    E-Print Network [OSTI]

    Miller-Fleming, Leonor; Olin-Sandoval, Viridiana; Campbell, Kate; Ralser, Markus

    2015-07-05

    , ubiquitin-independent proteasomal degradation, metabolite-induced proteolysis, a complex bi-directional membrane transport system and a unique posttranslational modification - hypusination - that is believed to occur on a single protein only eIF-5A. Many...

  12. Therapeutics, Targets, and Chemical Biology Real-time In Vivo Molecular Detection of Primary Tumors and

    E-Print Network [OSTI]

    Tsien, Roger Y.

    T. Nguyen2 Abstract Management of metastatic disease is integral to cancer treatment. Evaluation protease sensors and sentinel lymph node detection methods, which give no information about cancer invasion. Cancer Res; 73(2); 855­64. Ó2012 AACR. Introduction Cancer staging depends on evaluation of both

  13. A computer scientist's guide to molecular biology L. Kari, R. Kitto, G. Gloor

    E-Print Network [OSTI]

    Kari, Lila

    different building blocks, called bases. The bases are abbreviated A, C, G, T and they are the letters computing. By its very nature, the paper is schematic rather than complete, and tries to compress in a few and development of virtually all life on this planet. Although DNA has been shaping life on Earth for billions

  14. Metabolomics of Complex Biological Systems to Uncover Molecular Mechanisms in Rice and Other Organisms

    E-Print Network [OSTI]

    Barding, Gregory Alan

    2013-01-01

    dat3[,i],lty=2, type="o", lwd=1) legend(1,g_range[2],c(xlab="ppm",ylab="Intensity",lwd=0.2,ylim=c(0,ycut),xlim=xax,xlab="ppm",ylab="Intensity",lwd=0.2,ylim=c(0,ycut),xaxt="n",

  15. Insect Molecular Biology (2004) 13(1), 3744 2004 The Royal Entomological Society 37

    E-Print Network [OSTI]

    Severson, David

    2004-01-01

    Publishing Ltd. Characterization of an Aedes aegypti bacterial artificial chromosome (BAC) library parasites. Here we describe our efforts to characterize a bacterial artificial chromosome genomic library for the yellow fever mosquito, Aedes aegypti, and to identify BAC clones containing genetic markers that define

  16. THEJOURNALOF BIOLOGICALCHEMISTRY Q 1989 by The American Societyfor Biochemistryand MolecularBiology, Inc.

    E-Print Network [OSTI]

    . donouani is a unique glycoconjugatecalled lipophosphoglycan (LPG).' It has been proposed (2) that LPG may, the L. donovani LPG (M,=9,000) is apolymer * This investigation was supported by the United Nations. of Biochemistry, University of Dundee, Dundee DD14HN, United Kingdom. The abbreviations used are: LPG

  17. By Laura Hilton & Lynne Quarmby Molecular Biology & Biochemistry, Simon Fraser University

    E-Print Network [OSTI]

    Quarmby, Lynne M.

    in reference to some cilia ­ such as sperm tails and the cilia of some Protists would have been obvious as early naturalists watched the protists of pond water

  18. MOLECULAR AND CELLULAR BIOLOGY, 0270-7306/97/$04.00 0

    E-Print Network [OSTI]

    Spang, Rainer

    for this parasite heat shock protein during the initial stages of a mammalian infection. Under environmental stress the stress-induced expression of Hsp104, a member of the ClpB family of heat shock proteins (7, 26), leads to increased tolerance to heat stress and various chemical stresses (25, 33, 34). Hsp104 forms a homohexamer

  19. Modulhandbuch M.Sc. Biochemistry and Molecular Biology Title of the module Electron transport

    E-Print Network [OSTI]

    Diekmann, Martin

    , mitochondria and plastids. Methods used in the practical course: · Differential centrifugation and organelle to understand advanced contents of electron transport and compartmentation in eukaryots. · Ability to conduct

  20. Understanding cell biology at the molecular level necessitates the careful characteriza-

    E-Print Network [OSTI]

    mitosis, our current knowledge of their canonical and proposed alternative functions does not allow us- cesses. Membrane trafficking and other pathways are suppressed, the cytoskeleton is reorganized