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1

CSMB | Center for Structural Molecular Biology | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

CSMB CSMB Capabilities Working with CSMB Home | User Facilities | CSMB CSMB | Center for Structural Molecular Biology SHARE The Center for Structural Molecular Biology at ORNL is dedicated to developing instrumentation and methods for determining the 3-dimensional structures of proteins, nucleic acids (DNA/RNA) and their higher order complexes. The tools of the CSMB will help understand how these macromolecular systems are formed and how they interact with other systems in living cells. The focus of the CSMB is to bridge the information gap between cellular function and the molecular mechanisms that drive it. The suite of tools being developed by the CSMB includes: Bio-SANS, a Small-Angle Neutron Scattering (SANS) facility for biological samples, has been completed at the ORNL High-Flux Isotope

2

NEWTON's Molecular Biology Videos  

NLE Websites -- All DOE Office Websites (Extended Search)

Molecular Biology Videos Do you have a great molecular biology video? Please click our Ideas page. Featured Videos: University of Berkeley - Molecular Biology Lectures University...

3

NEWTON's Molecular Biology Archive  

NLE Websites -- All DOE Office Websites (Extended Search)

Molecular Biology Archive: Loading Most Recent Molecular Biology Questions: Cytoplasm pH DNA Extract and Cold Alcohol Albino Gene Loci Male Development Candy and Bacteria Revisited...

4

Molecular Biology DEGREE PROGRAMME  

E-Print Network (OSTI)

BSc (Hons) Molecular Biology DEGREE PROGRAMME GUIDE 2013-2014 #12;BSc (Hons) Molecular Biology - Year 2 - Year 3 - Year 4 Introduction Molecular biology aims to understand living systems by focusing on the molecular components upon which they are built. Molecular biology is one of great successes of 20th century

Siddharthan, Advaith

5

Educational Molecular Biology Games  

NLE Websites -- All DOE Office Websites (Extended Search)

Molecular Biology Games Do you have a great game? Please click our Ideas page. Featured Games: Biology Games fom biologyjunction.com Biology Games fom biologyjunction.com...

6

NEWTON's Molecular Biology References  

NLE Websites -- All DOE Office Websites (Extended Search)

Molecular Biology References Molecular Biology References Do you have a great reference link? Please click our Ideas page. Featured Reference Links: The Vitual Museum of Bacteria The Vitual Museum of Bacteria Visit the virtual museum of bacteria to learn more about bacteria and germs! This site brings together many links on bacteria, bacteriology, and related topics available on the web. It also provides crystal-clear information about many aspects of bacteria. The American Society of Cell Biology Cell Biology Educational Resources This site, sponsered by the American Society of Cell Biology, provides additional web links to everything from, general educational sites, to biology course materials, to teaching tools and more. National Center for Biotechnology Information National Center for Biotechnology Information

7

CELL, MOLECULAR AND DEVELOPMENTAL BIOLOGY Graduation Requirements  

E-Print Network (OSTI)

CELL, MOLECULAR AND DEVELOPMENTAL BIOLOGY Graduation Requirements: A minimum 2.0 average in all in Biology III: Cell Structure and Function (2 cr.; fall) 6. BIOL 24100 Biology IV: Genetics and Molecular Biology (3 cr.; spring) 7. BIOL 24200 Laboratory in Genetics and Molecular Biology (2 cr.; spring) 8. BIOL

Jiang, Wen

8

The Entire Molecular Biology Archive  

NLE Websites -- All DOE Office Websites (Extended Search)

Molecular Biology Archives Molecular Biology Archives Molecular Biology, Since May 2000 Table of Contents: Blood pH and Oxygen DNA Extraction Flesh Eating Bacteria Amino Acid Differences Lyme Disease Effects Vinegar and Alcohol Mosquito and Blood Caffeine and Smoking Bread Mold and pH Hemocyanin and Hemerythrin Hodospin Man-made Bacteria Pregnancy Tips mRNA Killing Bacteria Gram Stain Milk Bacteria Denatured Protein Pseudmands Bacteria Nucleotide Order Bacteria Resistance Albinism Genes DNA Healing Re-constitution of Proteins H. pylori and Multiple sclerosis Smallest Organism Sugars and Fats Bacteria Systematics Slow Regeneration Media Cultures Butter and Bacteria AIDS and Survival in Air Cell Intelligence Giardia gingivalis Meat Bacteria Pus and Immune Cells Chalones Culture of T. ferrooxisans Amphibian E. coli

9

Molecular biology of signal transduction in plants  

Science Conference Proceedings (OSTI)

This volume contains abstracts of oral presentations and poster sessions of the 1991 Cold Springs Harbor Meeting entitled Molecular Biology of Signal Transduction in Plants.

Not Available

1991-01-01T23:59:59.000Z

10

Molecular and Systems Biology | Biosciences Division  

NLE Websites -- All DOE Office Websites (Extended Search)

the molecular function information derived from these studies will enable synthetic biology approaches that modulate the system response by manipulating components of...

11

Molecular and Systems Biology | Biosciences Division  

NLE Websites -- All DOE Office Websites (Extended Search)

Molecular and Systems Biology BIO Home Page About BIO News Releases Research Publications People Contact Us Organization Chart Site Index Inside BIO BIO Safety About Argonne...

12

BE.442 Molecular Structure of Biological Materials, Fall 2005  

E-Print Network (OSTI)

Basic molecular structural principles of biological materials. Molecular structures of various materials of biological origin, including collagen, silk, bone, protein adhesives, GFP, self-assembling peptides. Molecular ...

Zhang, Shuguang, Dr.

13

BE.442 Molecular Structure of Biological Materials, Fall 2002  

E-Print Network (OSTI)

Basic molecular structural principles of biological materials. Molecular structures of various materials of biological origin, including collagen, silk, bone, protein adhesives, GFP, self-assembling peptides. Molecular ...

Zhang, Shuguang, Dr.

14

Learning molecular biology by VR playing  

Science Conference Proceedings (OSTI)

Learning by playing is one of the natural way for knowledge and skill acquisition. This paper addresses the issue of learning molecular biology by Virtual Reality (VR) based playing. A software system MolecularStudio is developed using the VR Technology ... Keywords: VR, biology, computer game, learning, playing

BF Lu; KT Lim; JM Zheng; YY Cai

2004-06-01T23:59:59.000Z

15

Genetics and molecular biology of breast cancer  

SciTech Connect

This volume contains the abstracts of oral presentations and poster sessions presented at the Cold Springs Harbor Meeting on Cancer Cells, this meeting entitled Genetics and Molecular Biology of Breast Cancer.

King, M.C. [California Univ., Berkeley, CA (United States); Lippman, M. [Georgetown Univ. Medical Center, Washington, DC (United States)] [comps.

1992-12-31T23:59:59.000Z

16

Micronutrients and Health: Molecular Biological Mechanisms  

Science Conference Proceedings (OSTI)

This book contains papers presented at a workshop on micronutrients and health held in 2000. Micronutrients and Health: Molecular Biological Mechanisms Health acid analysis aocs april articles chloropropanediol contaminants detergents dietary fats divisi

17

Molecular, Cellular, Developmental Biology and Genetics Graduate Student Seminar Series  

E-Print Network (OSTI)

Molecular, Cellular, Developmental Biology and Genetics Graduate Student Seminar Series FALL 2013 regulation of torsinA during cellular polarization #12;Molecular, Cellular, Developmental Biology

Amin, S. Massoud

18

Molecular Mechanism of Biological Proton Transport  

Science Conference Proceedings (OSTI)

Proton transport across lipid membranes is a fundamental aspect of biological energy transduction (metabolism). This function is mediated by a Grotthuss mechanism involving proton hopping along hydrogen-bonded networks embedded in membrane-spanning proteins. Using molecular simulations, the authors have explored the structural, dynamic, and thermodynamic properties giving rise to long-range proton translocation in hydrogen-bonded networks involving water molecules, or water wires, which are emerging as ubiquitous H{sup +}-transport devices in biological systems.

Pomes, R.

1998-09-01T23:59:59.000Z

19

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, Mar.  

NLE Websites -- All DOE Office Websites (Extended Search)

MICROBIOLOGY MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, Mar. 2009, p. 62-70 Vol. 73, No. 1 1092-2172/09/$08.00ϩ0 doi:10.1128/MMBR.00028-08 Copyright © 2009, American Society for Microbiology. All Rights Reserved. Environmental Proteomics: a Paradigm Shift in Characterizing Microbial Activities at the Molecular Level Martin Keller 1 * and Robert Hettich 2 Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, 1 and Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831 2 INTRODUCTION .........................................................................................................................................................62 Does Microbial Composition Affect Ecosystem Processes? ................................................................................62 Proteomics

20

2011 Archaea: Ecology, Metabolism, & Molecular Biology  

Science Conference Proceedings (OSTI)

Archaea, one of three major evolutionary lineages of life, are a fascinating and diverse group of microbes with deep roots overlapping those of eukaryotes. The focus of the 'Archaea: Ecology Metabolism & Molecular Biology' GRC conference expands on a number of emerging topics highlighting new paradigms in archaeal metabolism, genome function and systems biology; information processing; evolution and the tree of life; the ecology and diversity of archaea and their viruses. The strength of this conference lies in its ability to couple a field with a rich history in high quality research with new scientific findings in an atmosphere of stimulating exchange. This conference remains an excellent opportunity for younger scientists to interact with world experts in this field.

Keneth Stedman

2011-08-05T23:59:59.000Z

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

A bibliography on computational molecular biology and genetics  

Science Conference Proceedings (OSTI)

The field of computational molecular biology and genetics is expanding at an enormous rate. Journals such as CABIOS and Nucleic Acids Research routinely publish articles on computational and mathematical aspects of biology. The purpose of this paper ...

Sarah Barron; Matthew Witten; Gongxian Liu

1992-06-01T23:59:59.000Z

22

2010 Plant Molecular Biology Gordon Research Conference  

SciTech Connect

The Plant Molecular Biology Conference has traditionally covered a breadth of exciting topics and the 2010 conference will continue in that tradition. Emerging concerns about food security have inspired a program with three main themes: (1) genomics, natural variation and breeding to understand adaptation and crop improvement, (2) hormonal cross talk, and (3) plant/microbe interactions. There are also sessions on epigenetics and proteomics/metabolomics. Thus this conference will bring together a range of disciplines, will foster the exchange of ideas and enable participants to learn of the latest developments and ideas in diverse areas of plant biology. The conference provides an excellent opportunity for individuals to discuss their research because additional speakers in each session will be selected from submitted abstracts. There will also be a poster session each day for a two-hour period prior to dinner. In particular, this conference plays a key role in enabling students and postdocs (the next generation of research leaders) to mingle with pioneers in multiple areas of plant science.

Michael Sussman

2010-07-23T23:59:59.000Z

23

Molecular biology of signal transduction in plants. Abstracts  

Science Conference Proceedings (OSTI)

This volume contains abstracts of oral presentations and poster sessions of the 1991 Cold Springs Harbor Meeting entitled Molecular Biology of Signal Transduction in Plants.

Not Available

1991-12-31T23:59:59.000Z

24

Third international congress of plant molecular biology: Molecular biology of plant growth and development  

Science Conference Proceedings (OSTI)

The Congress was held October 6-11, 1991 in Tucson with approximately 3000 scientists attending and over 300 oral presentations and 1800 posters. Plant molecular biology is one of the most rapidly developing areas of the biological sciences. Recent advances in the ability to isolate genes, to study their expression, and to create transgenic plants have had a major impact on our understanding of the many fundamental plant processes. In addition, new approaches have been created to improve plants for agricultural purposes. This is a book of presentation and posters from the conference.

Hallick, R.B. [ed.

1995-02-01T23:59:59.000Z

25

The Molecular Foundry - Biological Nanostructures - Overview  

NLE Websites -- All DOE Office Websites (Extended Search)

to produce nano-scale assemblies; 2) analysis of biological systems using new nanocrystal-based luminescent probes; and 3) mimicry of precise biological architectures with...

26

The Molecular Foundry - Biological Nanostructures - Staff - Caroline...  

NLE Websites -- All DOE Office Websites (Extended Search)

Caroline Ajo-Franklin Overview Capabilities & Tools Staff Staff Publications User Publications Staff Scientist, Biological Nanostructures Facility cajo-franklin@lbl.gov...

27

When worlds collide: molecular biology as interdisciplinary collaboration  

Science Conference Proceedings (OSTI)

The field of molecular biology is in a remarkably rapid period of change, as the genome sequencing projects and new experimental technologies have generated an explosion of data To analyze and draw insights from the vast amounts of information, biologists ...

Vicki O'Day; Annette Adler; Allan Kuchinsky; Anna Bouch

2001-09-01T23:59:59.000Z

28

Chemistry Central Journal Commentary Molecular biology: Self-sustaining chemistry  

E-Print Network (OSTI)

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Molecular biology is an established interdisciplinary field within biology that deals fundamentally with the function of any nucleic acid in the cellular context. The molecular biology section in Chemistry Central Journal focusses on the genetically determined chemistry and biochemistry occuring in the cell. How can thousands of chemical reactions interact smoothly to maintain the life of cells, even in a variable environment? How is this self-sustaining system achieved? These are questions that should be answered in the light of molecular biology and evolution, but with the application of biophysical, physico-chemical, analytical and preparative technologies. As the Section Editor for the molecular biology section in Chemistry Central Journal, I hope to receive manuscripts that present new approaches aimed at better answering and shedding light upon these fascinating questions related to the chemistry of livings cells. Molecular biology in Chemistry Central Journal At the outset, let me pose two important questions: Why

Paul Wrede

2007-01-01T23:59:59.000Z

29

Molecular biology, a widely used expression for a changeable meaning Gabriel Gachelin  

E-Print Network (OSTI)

1 Molecular biology, a widely used expression for a changeable meaning Gabriel Gachelin Centre de to introduce the round table on the dynamics of molecular biology and to take the opportunity to express my personal view on that question. "Molecular biology" is a widely accepted term. Numerous excellent studies

Paris-Sud XI, Université de

30

Molecular Imaging Approaches to Understanding the Roles of Copper in Biology  

E-Print Network (OSTI)

Alberts, B. et al. Molecular Biology of the Cell (Taylor &Rosenzweig, A. C. Structural biology of copper trafficking.Opinion in Chemical Biology 2000, 4, 140-147. Waggoner, D.

Domaille, Dylan

2011-01-01T23:59:59.000Z

31

From Molecular Cell Engineering to Biologically Inspired Engineering DONALD E. INGBER  

E-Print Network (OSTI)

From Molecular Cell Engineering to Biologically Inspired Engineering DONALD E. INGBER Departments) Abstract--The field of Molecular Cell Engineering melds techniques from molecular cell biology, engineering, such as how cells self organize through collective interactions among thousands of individ- ual molecular

Ingber, Donald E.

32

Molecular Biology, Pathobiology, and Genetics Intrinsic Gene Expression Profiles of Gliomas Are a Better  

E-Print Network (OSTI)

Molecular Biology, Pathobiology, and Genetics Intrinsic Gene Expression Profiles of Gliomas distinct molecular subgroups that correlate with survival. These include two favorable prognostic subgroups with poor prognosis (median survival, molecular subtypes

33

International Conference on the Cell and Molecular Biology of Chlamydomonas  

DOE Green Energy (OSTI)

The 2010 Conference on the Cell and Molecular Biology of Chlamydomonas was held June 6-10 near Boston, MA, and attracted a record 273 participants, 146 from US labs, 10 from Canada, and the remainder from 18 other countries. The single-celled algal protist Chlamydomonas is a key research organism for many investigators, including those who study photosynthesis, cell motility, adaptation to environmental stresses, the evolution of multicellularity, and the production of biofuels. Chlamydomonas researchers gather every two years at a research conference to exchange methods, develop collaborative efforts, disseminate recent findings, and plan large-scale studies to improve the usefulness of this unique research organism. This conference provides the only opportunity for Chlamydomonas scientists who work on different research problems to meet face to face, and greatly speeds progress in their respective fields. An important function of these Chlamydomonas conferences is to promote and showcase the work of younger scientists, and to attract new investigators into the Chlamydomonas community. DOE award SC0004085 was used to offset the travel and registration costs for 18 young investigators, 9 of whom were women, including one African American. Most of these scientists would not have been able to attend the conference without DOE support. A total of 208 research presentations were made at the meeting, 80 talks (63 presented by students, postdocs, and pre-tenured faculty) and 128 posters. Cell motility and biofuels/metabolism were the best-represented research areas, with a total of 77 presentations. This fact underscores the growing importance of Chlamydomonas as a research and production tool in the rapidly expanding world of biofuels research. A total of 28 talks and posters were presented on the topics of photosynthesis and stress responses, which were among the next best-represented research areas. As at several recent Chlamydomonas meetings, important advances were reported in the area of tool development, advances that conference attendees should be able to employ in their own labs to speed the analysis of gene function. In summary, support from DOE award SC0004085 helped to make the 2010 Conference on the Cell and Molecular Biology of Chlamydomonas an unqualified success. Thanks to that support it was possible to attract a new cohort of young investigators to this biennial conference. These young scientists benefited from the opportunity to present their results to, and to interact with, the international Chlamydomonas research community. The Chlamydomonas community benefited by learning about the advances reported by these scientists, and it will continue to benefit from the contributions these investigators will make as their training and careers progress.

Dr. Stephen Miller

2010-06-10T23:59:59.000Z

34

2012 PLANT MOLECULAR BIOLOGY GORDON RESEARCH CONFERENCE, JULY 15-20, 2012  

SciTech Connect

The 2012 Gordon Conference on Plant Molecular Biology will present cutting-edge research on molecular aspects of plant growth and development, with particular emphasis on recent discoveries in molecular mechanisms involved with plant signaling systems. The Conference will feature a wide range of topics in plant molecular biology including hormone receptors and early events in hormone signaling, plant perception of and response to plant pathogen and symbionts, as well as technological and biological aspects of epigenomics particularly as it relates to signaling systems that regulate plant growth and development. Genomic approaches to plant signaling will be emphasized, including genomic profiling technologies for quantifying various biological subsystems, such as the epigenome, transcriptome, phosphorylome, and metabolome. The meeting will include an important session devoted to answering the question, "What are the biological and technological limits of plant breeding/genetics, and how can they be solved"?

Sussman, Michael

2013-07-20T23:59:59.000Z

35

Molecular and cell biology of arbuscular mycorrhizal symbiosis  

Science Conference Proceedings (OSTI)

abiotic stress (e.g. nutrient or water deficiency). .... Further tools for molecular work encompass proto- .... compounds to split petri dishes harbouring Ri T-DNA-.

36

DFT-based molecular dynamics as a new tool for computational biology: first applications and perspective  

Science Conference Proceedings (OSTI)

Static and molecular dynamics (MD) calculations based on density-functional theory (DFT) are emerging as a valuable means for simulations in the field of biology, especially when coupled with classical simulations. In this contribution, we point out ...

W. Andreoni; A. Curioni; T. Mordasini

2001-05-01T23:59:59.000Z

37

Virology Journal BioMed Central Commentary Bacteriophages: The viruses for all seasons of molecular biology  

E-Print Network (OSTI)

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Bacteriophage research continues to break new ground in our understanding of the basic molecular mechanisms of gene action and biological structure. The abundance of bacteriophages in nature and the diversity of their genomes are two reasons why phage research brims with excitement. The pages of Virology Journal will reflect the excitement of the "New Phage Biology." The launching of Virology Journal comes at a time of resurgence of interest in the basic biology of the bacteriophages and the impact that these viruses have on earth's ecology, evolution of microbial diversity and the control of infectious disease. Since playing an important part in the birth of Molecular Biology more than 50 years ago [1], phage research has continually broken new ground in our understanding of the basic molecular mechanisms of gene action and biological structure [2]. This trend shows no

Jim D Karam; Jim D Karam

2005-01-01T23:59:59.000Z

38

2012 CELLULAR & MOLECULAR FUNGAL BIOLOGY GORDON RESEARCH CONFERENCE, JUNE 17 - 22, 2012  

SciTech Connect

The Gordon Research Conference on CELLULAR & MOLECULAR FUNGAL BIOLOGY was held at Holderness School, Holderness New Hampshire, June 17 - 22, 2012. The 2012 Gordon Conference on Cellular and Molecular Fungal Biology (CMFB) will present the latest, cutting-edge research on the exciting and growing field of molecular and cellular aspects of fungal biology. Topics will range from yeast to filamentous fungi, from model systems to economically important organisms, and from saprophytes and commensals to pathogens of plants and animals. The CMFB conference will feature a wide range of topics including systems biology, cell biology and morphogenesis, organismal interactions, genome organisation and regulation, pathogenesis, energy metabolism, biomass production and population genomics. The Conference was well-attended with 136 participants. Gordon Research Conferences does not permit publication of meeting proceedings.

Judith Berman

2012-06-22T23:59:59.000Z

39

Molecular gyroscopes and biological effects of weak ELF magnetic fields  

E-Print Network (OSTI)

Extremely-low-frequency magnetic fields are known to affect biological systems. In many cases, biological effects display `windows' in biologically effective parameters of the magnetic fields: most dramatic is the fact that relatively intense magnetic fields sometimes do not cause appreciable effect, while smaller fields of the order of 10--100 $\\mu$T do. Linear resonant physical processes do not explain frequency windows in this case. Amplitude window phenomena suggest a nonlinear physical mechanism. Such a nonlinear mechanism has been proposed recently to explain those `windows'. It considers quantum-interference effects on protein-bound substrate ions. Magnetic fields cause an interference of ion quantum states and change the probability of ion-protein dissociation. This ion-interference mechanism predicts specific magnetic-field frequency and amplitude windows within which biological effects occur. It agrees with a lot of experiments. However, according to the mechanism, the lifetime $\\Gamma^{-1}$ of ion ...

Savin, A V

2002-01-01T23:59:59.000Z

40

Automatically constructing a directory of molecular biology databases  

Science Conference Proceedings (OSTI)

There has been an explosion in the volume of biology-related information that is available in online databases. But finding the right information can be challenging. Not only is this information spread over multiple sources, but often, it is hidden behind ...

Luciano Barbosa; Sumit Tandon; Juliana Freire

2007-06-01T23:59:59.000Z

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Modeling human risk: Cell & molecular biology in context  

SciTech Connect

It is anticipated that early in the next century manned missions into outer space will occur, with a mission to Mars scheduled between 2015 and 2020. However, before such missions can be undertaken, a realistic estimation of the potential risks to the flight crews is required. One of the uncertainties remaining in this risk estimation is that posed by the effects of exposure to the radiation environment of outer space. Although the composition of this environment is fairly well understood, the biological effects arising from exposure to it are not. The reasons for this are three-fold: (1) A small but highly significant component of the radiation spectrum in outer space consists of highly charged, high energy (HZE) particles which are not routinely experienced on earth, and for which there are insufficient data on biological effects; (2) Most studies on the biological effects of radiation to date have been high-dose, high dose-rate, whereas in space, with the exception of solar particle events, radiation exposures will be low-dose, low dose-rate; (3) Although it has been established that the virtual absence of gravity in space has a profound effect on human physiology, it is not clear whether these effects will act synergistically with those of radiation exposure. A select panel will evaluate the utilizing experiments and models to accurately predict the risks associated with exposure to HZE particles. Topics of research include cellular and tissue response, health effects associated with radiation damage, model animal systems, and critical markers of Radiation response.

1997-06-01T23:59:59.000Z

42

The molecular biology and biochemistry of rice endosperm. alpha. -globulin  

SciTech Connect

The author's first objective was to isolate a cDNA clone that encodes the rice endosperm {alpha}-globulin. Purified antibodies against a rice storage protein, {alpha}-globulin, were used to screen a {lambda}gt11 cDNA expression library constructed from immature rice seed endosperm. The cDNA insert of clone 4A1 (identified by antibody screening) was used as a probe to identify long cDNA inserts in the library. The deduced amino acid sequence of clone A3-12 cDNA insert (identified by cDNA screening) contained the amino acid sequences of three cyanogen bromide peptides fragment of {alpha}-globulin. The calculated molecular weight and amino acid composition of the deduced amino acid sequence were similar to the {alpha}-globulin protein. Northern blot analysis indicated that mRNA of one size, approximately 1.0 kb, is expressed. Southern genomic blot analysis revealed one band with EcoRI or Hind III digestion. Cell-free translation and immunoprecipitation showed that the initial translation product is approximately 2,000 daltons larger than the mature protein. The amino acid sequence of {alpha}-globulin revealed limited regions of similarities with wheat storage proteins. The author concludes that the cDNA insert in clone A3-12 contained the entire coding region of {alpha}-globulin protein and that {alpha}-globulin is encoded by a single gene. My second objective was to inhibit the degradation of {alpha}-globulin in the salt extract of rice flour. The salt extract of rice flour contained an acid protease whose optimal pH was 3 for {sup 3}H-casein hydrolysis. A polypeptide with molecular weight of 20,000 was immunologically reactive with {alpha}-globulin antibodies and is produced by limited proteolysis in the extract. Pepstatin inhibited the proteolysis of 3H-casein and slowed the proteolysis of {alpha}-globulin.

Shorrosh, B.S.

1989-01-01T23:59:59.000Z

43

Genetics and molecular biology of methanogen genes. Final report  

DOE Green Energy (OSTI)

Adenylate kinase has been isolated from four related methanogenic members of the Archaea. For each the optimum temperature for enzyme activity was similar to the temperature for optimal microbial growth and was approximately 30 C for Methanococcus voltage, 70 C for Methanococcus thermolithotrophicus, 80 C for Methanococcus igneus and 80--90 C for Methanococcus jannaschii. The enzymes were sensitive to the adenylate kinase inhibitor, Ap{sub 5}A [P{sup 1}, P{sup 5}-di(adenosine-5{prime}) pentaphosphate], a property that was exploited to purify the enzymes by CIBACRON Blue affinity chromatography. The enzymes had an estimated molecular weight (approximately 23--25 kDa) in the range common for adenylate kinases. Each of the enzymes had a region of amino acid sequence close to its N-terminus that was similar to the canonical P-loop sequence reported for all adenylate kinases. However, the methanogen sequences lacked a lysine residue that has previously been found to be invariant in adenylate kinases including an enzyme isolated from the Archeon, Sulfolobus acidocaldarius. If verified as a nucleotide binding domain, the methanogen sequence would represent a novel nucleotide binding motif. There was no correlation between amino acid abundance and the optimal temperature for enzyme activity.

Konisky, J.

1997-10-07T23:59:59.000Z

44

Exploring the free-energy landscapes of biological systems with steered molecular dynamics  

E-Print Network (OSTI)

1 Exploring the free-energy landscapes of biological systems with steered molecular dynamics fluctuation-dissipation-theorem (BD -FDT) to accurately compute the free-energy profiles for several compute the free-energy profiles for all the afore-listed systems that represent various important aspects

Chen, Liao Y.

45

Transforming molecular biology research through extreme acceleration of AMBER molecular dynamics simulations: sampling for the 99%  

Science Conference Proceedings (OSTI)

This talk will cover recent developments in the acceleration of Molecular Dynamics Simulations using NVIDIA Graphics Processing units with the AMBER software package. In particular it will focus on recent algorithmic improvements aimed at accelerating ...

Ross C. Walker; Levi Pierce; Romelia Salomon

2012-07-01T23:59:59.000Z

46

Carotenoids & Retinoids; Molecular Aspects and Health IssuesChapter 10 Biological Activity of Lycopene Against Smoke-Induced Lung Lesions  

Science Conference Proceedings (OSTI)

Carotenoids & Retinoids; Molecular Aspects and Health Issues Chapter 10 Biological Activity of Lycopene Against Smoke-Induced Lung Lesions Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry Press ...

47

2010 CELL AND MOLECULAR FUNGAL BIOLOGY GORDON RESEARCH CONFERENCE, JUNE 13-18, 2010  

DOE Green Energy (OSTI)

The Cellular and Molecular Fungal Biology Conference provides a forum for presentation of the latest advances in fungal research with an emphasis on filamentous fungi. This open-registration scientific meeting brings together the leading scientists from academia, government and industry to discuss current research results and future directions at Holderness School, an outstanding venue for scientific interaction. A key objective of the conference is to foster interaction among scientists working on model fungi such as Saccharomyces cerevisiae, Schizosaccharomyces pombe, Neurospora crassa and Aspergillus nidulans and scientists working on a variety of filamentous fungi whose laboratory tractability is often inversely proportional to their medical, industrial or ecological importance. Sessions will be devoted to Systems Biology, Fungi and Cellulosic Biomass, Small RNAs, Population Genomics, Symbioses, Pathogenesis, Membrane Trafficking and Polarity, and Cytoskeleton and Motors. A session will also be devoted to hot topics picked from abstracts. The CMFB conference provides a unique opportunity to examine the breadth of fungal biology in a small meeting format that encourages in-depth discussion among the attendees.

Michelle Momany

2010-06-18T23:59:59.000Z

48

Molecular Biology of the Brain, edited by S.J. Higgins. Princeton, NJ: Princeton University Press, 1999. 196 pp. $32.50.  

E-Print Network (OSTI)

Molecular Biology of the Brain, edited by S.J. Higgins. Princeton, NJ: Princeton University Press level is one of the great- est and most important questions facing science. The Molecular Biology of the Brain reviews the state of current knowledge about the molecular foundations of brain function and gives

Schoenemann, P. Thomas

49

Molecular Responses to Climate and Resource Availability: Emerging Evidence from Systems Biology Research in Populus.  

SciTech Connect

The emergence of Populus as a model system for tree biology continues to be driven by a community of scientists dedicated to developing the resources needed to undertake genetic and functional genomic studies in this genus. As a result, understanding the molecular processes that underpin the growth and development of cottonwood, aspen, and hybrid poplar has steadily increased over the last several decades. Recently, our ability to examine the basic mechanisms whereby trees respond to a changing climate and resource limitations has benefitted greatly from the sequencing of the P. trichocarpa genome. This landmark event has laid a solid foundation upon which tree biologists can now explore the genome-wide effects of temperature, water and nutrient limitations on processes that govern the growth and development of some of the longest living and tallest growing organisms on Earth. Although the challenges likely to be encountered by scientists who work with trees are many, recent literature provides a number of examples whereby a systems approach, one that focuses on transcriptomic, proteomic, and metabolomic analyses is beginning to provide insights into the molecular-scale response of poplars to their climatic and edaphic environment.

Wullschleger, Stan D [ORNL; Weston, David [ORNL; Davis, John M [University of Florida

2009-01-01T23:59:59.000Z

50

Biology  

NLE Websites -- All DOE Office Websites (Extended Search)

Biology @WIPP Life Begins at 250,000,000 Years WIPP's underground isn't just suited for physics experiments aiming to unlock the mysteries of the Universe, it is also a perfect...

51

Molecular Imaging Approaches to Understanding the Roles of Hydrogen Peroxide Biology in Stress and Development  

E-Print Network (OSTI)

M. ; Blasco, M. A. The common biology of cancer and ageing.J. D. NOX enzymes and the biology of reactive oxygen. Nat.C. Reconciling the chemistry and biology of reactive oxygen

Dickinson, Bryan Craig

2010-01-01T23:59:59.000Z

52

Biologic  

E-Print Network (OSTI)

In this paper we explore the boundary between biology and the study of formal systems (logic). In the end, we arrive at a summary formalism, a chapter in "boundary mathematics" where there are not only containers but also extainers >biologic what boolean algebra is to classical logic. We show how this formalism encompasses significant parts of the logic of DNA replication, the Dirac formalism for quantum mechanics, formalisms for protein folding and the basic structure of the Temperley Lieb algebra at the foundations of topological invariants of knots and links.

Louis H. Kauffman

2002-04-02T23:59:59.000Z

53

Molecular Biology and Genetics of the Acetate-Utilizing Methanogenic Bacteria  

DOE Green Energy (OSTI)

Methane biosynthesis by the Methanosarcina species, in contrast to other methanogens, occurs from the full range of methanogenic substrates that include acetate, methanol, tri-methyl, di-methyl, and methyl-amine, methyl-sulfides, and in limited instances, H2/CO2. The Methanosarcina are also versatile in their ability to adapt and grow in habitats of varying osmolarity ranging from fresh water environments, marine environments, and to hyper saline environments (ca to 1.2 M NaCl). To facilitate studies that address the biochemistry, molecular biology and physiology of these organisms, we have constructed a whole-genome microarray to identify classes of differentially expressed genes in M. mazei strain Goe1. We propose to further identify and examine how genes and their proteins involved in the synthesis and transport of osmolytes in the cell are regulated. These compounds include N-epsilon-acetyl-beta-lysine, alpha-glutamate, betaine, and potassium whose levels within the cell are modulated in order to provide appropriate osmotic balance. We will identify differentially expressed genes involved in hydrogen and carbon dioxide sequestration since M. mazei strain Goe1 is currently the only practical model for such study. Finally, we will explore the essential roles of two metals, molybdate and tungstate, in methanogen regulation and metabolism of these environmentally essential organsims. The above studies will advance our general understanding of how methanogens respond to their environmental signals, and adapt by adjusting their physiology to thrive in changing anaerobic habitats whether natural or man-made.

Robert P. Gunsalus

2003-07-21T23:59:59.000Z

54

Molecular Weight of Condensed Tannins from Warm-season Perennial Legumes and Its Effect on Condensed Tannin Biological Activity  

E-Print Network (OSTI)

Condensed tannins (CT) are polyphenolic compounds that have demonstrated biological activities in ruminants including suppression of enteric methane (CH4) production, protein binding and suppression of gastrointestinal nematode (GIN) infections. Some forage CT have been reported to be biologically active, whereas others have demonstrated no biological activity at all. While the chemical structure of CT has been postulated to be a key contributing factor affecting biological activity, the specific factors that determine whether or not CT from a specific forage have bioactive properties remain unknown. Results from previous studies have shown that as molecular weight of CT increases, CT biological activity also increases. Others have reported no effect of CT molecular weight on biological activity. The relationship between molecular weight of CT and CT biological activity remains inconclusive. The effect of molecular weight of CT from a variety of warm-season perennial legumes commonly consumed by ruminants on biological activity has not been adequately explored. The objectives of this study were to determine if molecular weight of CT from warm-season perennial legumes could predict the biological activity of CT relative to suppression of enteric CH4 production, protein-binding ability (PB) and anthelmintic activity, and to compare the biological activity of CT from native warm-season perennial legumes to that of the introduced species Lespedeza cuneata, a plant that has gained attention in recent years due its anthelmintic properties. All or a combination of the following warm-season perennial legume species were evaluated for in vitro gas production, protein-precipitable phenolics (PPP) and PB, and percent larval migration inhibition (LMI). Eight North American native warm-season perennial legumes: Leucaena retusa Benth. (littleleaf leadtree), Desmanthus illinoensis (Michx.) MacMill. Ex B.L. Rob. & Fernald (Illinois bundleflower), Lespedeza stuevei Nutt. (tall lespedeza), Mimosa strigillosa Torr. & A. Gray (powderpuff), Neptunia lutea (Leavenworth) Benth. (yellow puff), two ecotypes of Acacia angustissima var. hirta (Nutt.) B.L. Rob (prairie acacia), Desmodium paniculatum (L.) DC. var. paniculatum (panicledleaf ticktrefoil), and two introduced legumes: Arachis glabrata Benth. (rhizoma peanut) and Lespedeza cuneata (Dum. Cours.) G. Don (sericea lespedeza) were included. In vitro CH4 production regressed on CT MW resulted in a R2 of 0.0009 (P = 0.80). There was no correlation between PPP or PB and MW of CT (R^2 0.11; P = 0.17 and R^2 0.02; P = 0.54, respectively). There was a weak correlation between CT MW and percent LMI (R^2 0.34; P = 0.05). The results of our study strongly suggested that CT MW does not explain the biological activities of enteric methane suppression or protein-binding ability. Condensed tannin MW may be involved in anthelmintic activity of CT from the forage legumes surveyed. North American native legumes containing biologically active CT, as compared to introduced species, were identified as having promise for use in ruminant diets.

Naumann, Harley Dean

2013-08-01T23:59:59.000Z

55

ANIMAL BEHAVIOR ANIMAL BIOLOGY ANTHROPOLOGY AVIAN SCIENCES BIOCHEMISTRY, MOLECULAR, CELLULAR AND DEVELOPMENTAL BIOLOGY BIOLOGICAL SYSTEMS ENGINEERING BIOMEDICAL ENGINEERING BIOPHYSICS BIOSTATISTICS CLINICAL RESEARCH  

E-Print Network (OSTI)

§ BIOSTATISTICS § CLINICAL RESEARCH COMPARATIVE PATHOLOGY § ECOLOGY § ENTOMOLOGY § ENVIRONMENTAL POLICY theory, hunter-gatherers, and North American prehistory); and 2. Sociocultural Anthropology (with, distribute and process biological products for energy, food, feed and fiber while conserving natural

Hammock, Bruce D.

56

Integrating the Molecular Machines of Mercury Detoxification into Host Cell Biology  

SciTech Connect

Integrating the Molecular Machines of Mercury Detoxification into Host Cell Biology The bacterial mercury resistance (mer) operon, one of the most evolutionarily successful genetic loci in any defined organism, detoxifies organic and inorganic mercury compounds. Several major biotic processes in the global Hg(II) cycle are carried out by bacteria with this highly mobile detoxification locus that occurs in Gram negative and high and low GC Gram positive bacteria. The functions of many individual mer operon components are well described, so we aim to dissect the higher order interactions of the enzymes, transporters, and regulators of this paradigm metal metabolizing system with each other and with the larger metabolism of the host cell. Understanding how this ubiquitous detoxification system fits into the biology and ecology of its bacterial host is essential to guide interventions that support and enhance Hg remediation. Specifically, we will test the hypotheses that: (a) the organomercurial lyase, MerB, and the mercuric reductase, MerA, act synergistically together and with the membrane-bound Hg(II) transporters, MerT and MerC, to detoxify mercurials; (b) the interaction of the metalloregulator MerR with RNA polymerase (RNAP) and with its DNA binding site, MerO, modulates its metal response, and interaction with its antagonist, MerD, prevents RNA polymerase from binding to the structural gene promoter, P merT and (c) exposure of cells to Hg(II) makes specific demands on cellular resources and expression of the mer operon modulates those demands and is, in turn, modulated by them. To test these hypotheses we propose to: (a) use enzymology, NMR, fluorescence anisotropy, protein-crosslinking, crystallography, and calorimetry in vitro along with in vivo measurements of Hg(II) volatilization and HgR phenotyping to detect and define interactions between the mer enzymes, MerA and MerB, and the transporters, MerT and MerC,and their functional fragments and specific mutant variants; (b) use NMR, fluorescence anisotropy, protein-crosslinking, crystallography, affinity pull-downs, and calorimetry in vitro along with in vivo measurements of transcript synthesis and HgR phenotyping to detect and define interactions between mer regulatory proteins (MerR and MerD), DNA sites (MerO, PT and PR), and RNA polymerase and their functional fragments and specific mutant variants; and (c) use 2D microarrays to define the Hg-inducible transcriptome of the model bacterium E. coli and of radionuclide-remediation model microorganisms, Shewanella oneidensis and Desulfovibrio vulgaris,with and without the mer operon. The information and insights obtained from this work will benefit the DOE-NABIR program by providing (a) a model for an evolutionarily successful metal detoxification system and (b) guidance for manipulations of field conditions so as to optimize the functioning of the cells which carry this detoxification system. The work will also contribute to the fundamental understanding of (a) the evolution of modular architecture in multi-domain proteins and (b) the integration of horizontally transferred genetic elements into pre-existing networks of cellular functions.

Summers, Anne O

2010-03-11T23:59:59.000Z

57

Constraint-Based Simulation of Biological Systems Described by Molecular Interaction Maps  

Science Conference Proceedings (OSTI)

We present a method to simulate biochemical networks described by the graphical notation of Molecular Inter- action Maps within stochastic Concurrent Constraint Pro- gramming. Such maps are compact, as they represent im- plicitly a wide set of reactions, ...

Luca Bortolussi; Simone Fonda; Alberto Policriti

2007-11-01T23:59:59.000Z

58

CHE 170: Molecular and Cell Biology for Engineers UCSB Department of Chemical Engineering  

E-Print Network (OSTI)

Office hours location: Engineering II 3201 Course text Essential Cell Biology, 3rd Edition. Alberts et al things you don't understand slip by unnoticed. 4. Think carefully and deeply. It is important to know, "What would happen in that problem if X were changed to Y?" Challenge yourself to think of possible

Shell, M. Scott

59

Molecular biology and genetics of the acetate-utilizing methanogenic bacteria  

DOE Green Energy (OSTI)

Acetate conversion to methane and C0{sub 2} by the methanogenic archaebacteria is a primary rate limiting step in anaerobic biodegradative processes in nature. However, the genetic study of these organisms has not been experimentally tractable due to the inability to grow and plate the organisms as single cells, and to extract high molecular weight DNA and RNA without shearing. The acetate-utilizing species, Methanosarcina thermolphila TM-1, is being used for the proposed genetic and molecular studies because, unlike previously described acetotrophic methanosarcina that have a thick heteropolysaccharide cell wall, this species can be cultured in a unicellular form that has a protein cell wall lacking the heteropolysaccharide layer. These cells can be gently disrupted to obtain protoplasts or lysed to yield intact genomic DNA and RNA. Experiments are in progress to develop a gene transfer system in this bacterial species. Methods are being developed and refined for the efficient plating of M. thermophila on defined media, for chemical mutagenesis, and for the isolation of mutants defective in acetate utilization. Chromosomal DNA libraries have been constructed from M. thermophila and are being used to clone genes involved in the acetate utilization pathway (e.g. carbon monoxide dehydrogenase). Once cloned, analysis of the molecular mechanisms responsible for their regulatory control will be performed. These studies should aid our understanding of the pathway for acetate utilization in M. thermophila and serve as a model for elucidating regulatory mechanisms in the acetotrophic methanogens.

Gunsalus, R.P.

1991-01-01T23:59:59.000Z

60

Radiation inactivation of hamster acrosin reveals that the biologically active unit is of low molecular size  

Science Conference Proceedings (OSTI)

The relationship between structure and activity of acid-extracted and purified acrosin obtained from cauda epididymal hamster spermatozoa was studied. A four-step purification procedure of acrosin was used; it included 1.) acid extraction, 2.) gel filtration over Sephadex G-100 resin, 3.) ion exchange on CM-Sepharose CL-6B, and 4.) affinity chromatography on proflavin-Sepharose 4B. Analysis of the purified enzyme by high-performance liquid chromatography (300 SW + I-125) revealed a molecular weight of 44,000, which was identical to that obtained for acid-extracted acrosin. Slab-gel electrophoresis under nondenaturing conditions showed only one active band, as revealed with a highly sensitive assay using N alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester as substrate. The radiation inactivation size of acid extracted acrosin was calculated to be 8400. This small unit could represent the active polypeptide portion of a larger monomer molecule or could represent the size of active subunits. Because acrosin is autocatalytic and highly active during fertilization, it is suggested that the active portion of the completely processed form of the enzyme is of small molecular weight.

Antaki, P.; Vigneault, N.; Beauregard, G.; Potier, M.; Roberts, K.D.

1987-08-01T23:59:59.000Z

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Computational Biology | More Science | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

Computational Biology SHARE Computational Biology Computational Biology research encompasses many important aspects including molecular biophysics for bio-energy, genetic level...

62

Resource Letter: Bio-molecular Nano-machines: where Physics, Chemistry, Biology and Technology meet  

E-Print Network (OSTI)

Cell is the structural and functional unit of life. This Resource Letter serves as a guide to the literature on nano-machines which drive not only intracellular movements, but also motility of the cell. These machines are usually proteins or macromolecular assemblies which require appropriate fuel for their operations. Although, traditionally, these machines were subjects of investigation in biology and biochemistry, increasing use of the concepts and techniques of physics in recent years have contributed to the quantitative understanding of the fundamental principles underlying their operational mechanisms. The possibility of exploiting these principles for the design and control of artificial nano-machines has opened up a new frontier in the bottom-up approach to nano-technology.

Debashish Chowdhury

2008-07-17T23:59:59.000Z

63

OAK RIDGE NATIONAL LABORATORY U. S. DEPARTMENT OF ENERGY  

E-Print Network (OSTI)

. CSMB, SNS, & HFIR3. CSMB, SNS, & HFIR -- Structural & Functional Analysis of Proteins, Nucleic acids

64

Systems biology of the cardiac hypoxia response in Drosophila  

E-Print Network (OSTI)

in Molecular Systems Biology , volume 3, article number 99,appear in Molecular Systems Biology. The dissertation authoret al. (2003) The systems biology markup language (SBML): a

Feala, Jacob Daniel

2008-01-01T23:59:59.000Z

65

Highlights from the Fourth International Society for Computational Biology Student Council Symposium at the Sixteenth Annual International Conference on Intelligent Systems for Molecular Biology  

E-Print Network (OSTI)

Council (SC) of the International Society for Computational Biology (ISCB) is a student-led, world- wide network of young researchers in computational biol- ogy and bioinformatics. The ISCB Board of Directors officially approved the SC in July 2004... eight abstracts chosen from oral presentations and a set of six best- ranked abstracts from the posters presented at the sympo- sium during the poster session. Rigorous peer review was carried out by members of the program committee, which comprised...

2008-10-30T23:59:59.000Z

66

BNL Biology Department - Videos  

NLE Websites -- All DOE Office Websites (Extended Search)

Walter Mangel "'Molecular Sleds' and More: Novel Antiviral Agents via Single Molecule Biology," in which he discusses antiviral agents, and in particular, the breakthrough work in...

67

Molecular Characterization of a Novel Class of DNA Binding Proteins  

E-Print Network (OSTI)

Current Protocols in Molecular Biology. Wiley, New York, NY.1997. Biological and molecular features of the relationshipsand G. Darai. 2002. Molecular anatomy of Chilo iridescent

Spears, Tatsinda Verity

2010-01-01T23:59:59.000Z

68

Molecular biology and genetics of the acetate-utilizing methanogenic bacteria. Progress report, [July 1, 1988--June 30, 1991  

DOE Green Energy (OSTI)

Acetate conversion to methane and C0{sub 2} by the methanogenic archaebacteria is a primary rate limiting step in anaerobic biodegradative processes in nature. However, the genetic study of these organisms has not been experimentally tractable due to the inability to grow and plate the organisms as single cells, and to extract high molecular weight DNA and RNA without shearing. The acetate-utilizing species, Methanosarcina thermolphila TM-1, is being used for the proposed genetic and molecular studies because, unlike previously described acetotrophic methanosarcina that have a thick heteropolysaccharide cell wall, this species can be cultured in a unicellular form that has a protein cell wall lacking the heteropolysaccharide layer. These cells can be gently disrupted to obtain protoplasts or lysed to yield intact genomic DNA and RNA. Experiments are in progress to develop a gene transfer system in this bacterial species. Methods are being developed and refined for the efficient plating of M. thermophila on defined media, for chemical mutagenesis, and for the isolation of mutants defective in acetate utilization. Chromosomal DNA libraries have been constructed from M. thermophila and are being used to clone genes involved in the acetate utilization pathway (e.g. carbon monoxide dehydrogenase). Once cloned, analysis of the molecular mechanisms responsible for their regulatory control will be performed. These studies should aid our understanding of the pathway for acetate utilization in M. thermophila and serve as a model for elucidating regulatory mechanisms in the acetotrophic methanogens.

Gunsalus, R.P.

1991-12-31T23:59:59.000Z

69

7.013 Introductory Biology, Spring 2005  

E-Print Network (OSTI)

The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological ...

Sive, Hazel L.

70

Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

is equipped with a variety of tools to aid in work with biomolecules, microbes, molecular biology techniques and cell culture. These tools include: a BioFlo fermentor (14 L),...

71

From virology to cell biology, understanding unconventional ubiquitination  

E-Print Network (OSTI)

From virology to cell biology, understanding unconventionalin Molecular and Cell Biology in the Graduate Division ofFrom virology to cell biology, understanding unconventional

Anania, Veronica Gina

2011-01-01T23:59:59.000Z

72

Bridging the gap between systems biology and medicine  

E-Print Network (OSTI)

Genomics and Systems Biology for Health, CNRS Institute ofTN 37208, USA; 7 Systems Biology and Bioinformatics Group,Canada; 9 Computational Biology Unit Molecular Biotechnology

2009-01-01T23:59:59.000Z

73

Biological Sciences at NERSC  

NLE Websites -- All DOE Office Websites (Extended Search)

Biological Sciences Biological Sciences Biological Sciences Better knowledge of biomolecules and processes they undergo is vital for achieving a predictive, systems-level understanding of complex biological systems that have potential use in bioenergy, carbon cycling and biosequestration, and biogeochemistry. Areas that NERSC helps to enable include: Research activities using genomics and systems biology to understand plants and microbes. Developing and applying atomistic-molecular to coarse-grained mathematical models of potential energy surfaces, characterizing these surfaces through sampling techniques and finally generating ensemble or time averaged physical properties of biological phenomena. Fundamental research in the redesign of microbial metabolic processes to harness their potential in the conversion of biomass to

74

7.012 Introduction to Biology, Fall 2001  

E-Print Network (OSTI)

Cell biology, immunology, neurobiology, and an exploration into current research in cancer, genomics, and molecular medicine.

Weinberg, Robert A. (Robert Allan), 1942-

75

BMC Evolutionary Biology BioMed Central  

E-Print Network (OSTI)

Research article Unveiling an ancient biological invasion: molecular analysis of an old European alien, the crested porcupine (Hystrix cristata)

Emiliano Trucchi; Valerio Sbordoni

2009-01-01T23:59:59.000Z

76

Biology Department - Brookhaven National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

Research Interests The protein folding problem is a fundamental question in molecular biology. We have initiated studies to examine the pathway of protein folding as it occurs in...

77

The Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

Seminar Schedule Abstract: The intriguing prospects of molecular electronics, nanotechnology, biomaterials, and the aim to close the gap between synthetic and biological...

78

Microfluidics for optics and quantitative cell biology  

E-Print Network (OSTI)

E. European Journal of Cell Biology 2006 . Thompson, D. M. ;S. H. Journal of Cell Biology 1977 , 75 , 606-616. Zicha,Physiology and Plant Molecular Biology 1997 , 48 , 493-523.

Campbell, James Kyle

2008-01-01T23:59:59.000Z

79

Monte Carlo simulation in systems biology  

E-Print Network (OSTI)

2 The history of Monte Carlo Sampling in Systems Biology 1.1simulation tools: the systems biology workbench and biospiceCellular and Molecular Biology. ASM Press, Washington

Schellenberger, Jan

2010-01-01T23:59:59.000Z

80

The Molecular Basis for Water Taste in Drosophila  

E-Print Network (OSTI)

odorant receptors: a molecular basis for odor recognition.J. , Weissman, J. , Julius, D. Molecular basis of infraredDarnell, J. (2000). Molecular Cell Biology, 4th edition.

Cameron, Peter

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

The Molecular Basis for Recognition of Oomycete Effectors in Arabidopsis  

E-Print Network (OSTI)

Bailey, K. , et al. , Molecular cloning of ATR5Emoy2 fromResistance proteins: molecular switches of plant defence, inresistance. EMBO (European Molecular Biology Organization)

Krasileva, Ksenia V.

2011-01-01T23:59:59.000Z

82

Assessing computational methods and science policy in systems biology.  

E-Print Network (OSTI)

??In this thesis, I discuss the development of systems biology and issues in the progression of this science discipline. Traditional molecular biology has been driven (more)

Castillo, Andrea R. (Andrea Redwing)

2009-01-01T23:59:59.000Z

83

Molecular Cell Short Article  

E-Print Network (OSTI)

Molecular Cell Short Article Nucleosome Organization Affects the Sensitivity of Gene Expression to Promoter Mutations Gil Hornung,1 Moshe Oren,2 and Naama Barkai1,* 1Department of Molecular Genetics 2Department of Molecular Cell Biology Weizmann Institute of Science, Rehovot, Israel *Correspondence: naama

Barkai, Naama

84

January 29, 2004 2:46 WSPC/Trim Size: 9in x 6in for Review Volume practicalbioinformatician MOLECULAR BIOLOGY FOR  

E-Print Network (OSTI)

's, G's, T's. This has led to the necessary marriage of biology and computer science into a new legendary experiments, Mendel mated pea plants with different pairs of traits--round vs. wrinkled seeds

Wong, Limsoon

85

Atomic Biology, Electrostatics, and Ionic Channels  

E-Print Network (OSTI)

I believe an atomic biology is needed to supplement present day molecular biology, if we are to design and understand proteins, as well as define, make, and use them.

Eisenberg, R S

2008-01-01T23:59:59.000Z

86

MOLECULAR AND CELLULAR BIOLOGY, Apr. 2010, p. 20572074 Vol. 30, No. 8 0270-7306/10/$12.00 doi:10.1128/MCB.01529-09  

E-Print Network (OSTI)

, Graduate School of Science, Osaka City University, Osaka 558-8585, Japan4 ; Department of Biology 2009/Accepted 25 January 2010 During yeast sporulation, a forespore membrane (FSM) initiates at each-pole body (SPB) and then extend to engulf the four nuclear lobes (the nuclear envelope does not break down

Pringle, John

87

Biology basics  

NLE Websites -- All DOE Office Websites (Extended Search)

Biology basics Name: lamb Status: NA Age: NA Location: NA Country: NA Date: Around 1993 Question: What basic knowledge concerning biology do you think a colleg- bound HS...

88

Soft Molecular Computing Computer Science  

E-Print Network (OSTI)

Soft Molecular Computing Max Garzon Computer Science The University of Memphis Memphis, TN 38152@memphis.edu Abstract Molecular computing (MC) utilizes the complex interaction of biomolecules and molecular biology for computational purposes. Five years later, substantial obstacles remain to bring the potential of molecular

Deaton, Russell J.

89

Molecular Foundry  

NLE Websites -- All DOE Office Websites

Berkeley Lab Berkeley Lab A-Z Index Phone Book Jobs Search DOE Berkeley Lab Berkeley Lab A-Z Index Phone Book Jobs Search DOE About the Foundry What is the Molecular Foundry? Research Themes Foundry Careers Media Gallery Other User Facilities external link Contact Us Go News & Highlights Users People Facilities Imaging and Manipulation Nanofabrication Theory Inorganic Biological Organic NCEM external link Seminars & Events Publications The Molecular Foundry is a Department of Energy-funded nanoscience research facility that provides users from around the world with access to cutting-edge expertise and instrumentation in a collaborative, multidisciplinary environment. Call for Proposals: The next deadline for standard proposals is Through March 31, 2014 Find out more information about becoming a Molecular Foundry facilities User. 2013 Annual User Meeting Postponed - Date TBD

90

From: Methods in Molecular Biology, vol. 400: Methods in Membrane Lipids Edited by: A. M. Dopico Humana Press Inc., Totowa, NJ  

E-Print Network (OSTI)

of molecular motions within the bilayer. For fluid bilayers, the dynamics of the lipids may encompass membrane deformations. In the fluid state, lipid membranes can bend locally with an energy cost undulations give rise to logarithmically varying positional correlations that generate scattering peaks

Brown, Michael F.

91

Biology Department - Brookhaven National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

of protein fingerprints: A novel information resource for computational molecular biology. J. Chem. Inf. Comput. Sci., 37:417-424 (1997). Bewley M.C., Lot, J.S., Baker E.N.,...

92

Single Molecule and Synthetic Biology Studies of Transcription  

E-Print Network (OSTI)

of the Society for Experimental Biology 12, Whler, F. Ueberin experimental medicine and biology 44, 23-4(1974). Weiss,ratchet. Journal of molecular biology 358, 241-54(2006).

Zamft, Bradley Michael

2011-01-01T23:59:59.000Z

93

Endothelial Biology/Homeostasis: The Roles of AMPK and SIRT1 in eNOS Phosphorylation and Deacetylation  

E-Print Network (OSTI)

RIVERSIDE Endothelial Biology/Homeostasis: The Roles of AMPKCellular and molecular biology of vascular remodeling." CurrTF and M Barton (1997). "Biology of the endothelium." Clin

Chen, Zhen

2010-01-01T23:59:59.000Z

94

Incorporation of the effect of the composite electric fields of molecular ions as a simulation tool for biological damage due to heavy-ion irradiation  

Science Conference Proceedings (OSTI)

This paper presents a theoretical study of the DNA damage due to the effect of the composite electric fields of H{sub 2}O{sup +} ions produced from the irradiation of a heavy ion onto a cell. A model for atomic and molecular processes in strong electric fields is developed. It is found that the composite electric fields increase the number of events of electron-impact ionization processes. This may promote DNA damage.

Moribayashi, Kengo [Quantum Beam Science Directorate, Japan Atomic Energy Agency, 8-1-7 Umemidai, Kizugawa-City, Kyoto 619-0215 (Japan) and Faculty of Life and Medical Sciences, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe City, Kyoto 610-0394 (Japan)

2011-07-15T23:59:59.000Z

95

Computational representation of biological systems  

SciTech Connect

Integration of large and diverse biological data sets is a daunting problem facing systems biology researchers. Exploring the complex issues of data validation, integration, and representation, we present a systematic approach for the management and analysis of large biological data sets based on data warehouses. Our system has been implemented in the Bioverse, a framework combining diverse protein information from a variety of knowledge areas such as molecular interactions, pathway localization, protein structure, and protein function.

Frazier, Zach; McDermott, Jason E.; Guerquin, Michal; Samudrala, Ram

2009-04-20T23:59:59.000Z

96

Molecular Analysis of Microglial Activation and Macrophage Recruitment in Murine Models of Neuroinflammation.  

E-Print Network (OSTI)

OF CALIFORNIA RIVERSIDE Molecular Analysis of Microglialof Philosophy in Cell, Molecular, and Developmental BiologyNMDA receptors : molecular mechanisms and therapeutic

Puntambekar, Shweta

2009-01-01T23:59:59.000Z

97

Incorporation of the effect of the composite electric fields of molecular ions as a simulation tool for biological damage due to heavy ion irradiation II  

SciTech Connect

This paper presents a theoretical study of the DNA damage due to the effect of the composite electric fields of H{sub 2}O{sup +} ions produced from the irradiation of a heavy ion onto a cell. It is found that a much larger number of electrons, which are produced from electron impact ionization, is trapped near the track of an incident ion in the case of C{sup 6+} ion irradiation with the energy of 3 MeV/u than that of proton irradiation. Therefore, the irradiation of carbon ions may produce a larger number of cluster DNA damage than that in the irradiation of protons. This may lead to the understanding of relative biological effectiveness (RBE).

Moribayashi, Kengo [Quantum Beam Science Directorate, Japan Atomic Energy Agency, 8-1-7, Umemidai, Kizugawa-city, 619-0215 (Japan) and Faculty of Life and Medical Sciences, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe City, 610-0394 (Japan)

2012-07-11T23:59:59.000Z

98

Biological Surety  

E-Print Network (OSTI)

o Identifies the purpose, concept, and responsibilities for the biological surety program (chap 1). o Identifies the following: procedures for requesting exceptions and waivers to biological surety policies; procedures for initiating and terminating surety status; and requirements for surety officers and surety boards (paras 1-5e, 1-6, and 1-7). o Establishes procedures for the biological personnel reliability program

unknown authors

2008-01-01T23:59:59.000Z

99

Molecular Cell Independence of Repressive Histone Marks  

E-Print Network (OSTI)

Molecular Cell Article Independence of Repressive Histone Marks and Chromatin Compaction during Children, Toronto, ON M5G 1X8, Canada 7MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK 8Cancer, Belgium 17Present address: Department of Biochemistry and Molecular Biology, Peking University, Health

Babu, M. Madan

100

Distribution and localization of microsatellites in the Perigord black truffle genome and identification of new molecular markers (2010) Fungal Genetics and Biology  

Science Conference Proceedings (OSTI)

The level of genetic diversity and genetic structure in the Perigord black truffle (Tuber melanosporum Vittad.) has been debated for several years, mainly due to the lack of appropriate genetic markers. Microsatellites or simple sequence repeats (SSRs) are important for the genome organisation, phenotypic diversity and are one of the most popular molecular markers. In this study, we surveyed the T. melanosporum genome (1) to characterise its SSR pattern; (2) to compare it with SSR patterns found in 48 other fungal and three oomycetes genomes and (3) to identify new polymorphic SSR markers for population genetics. The T. melanosporum genome is rich in SSRs with 22,425 SSRs with mono-nucleotides being the most frequent motifs. SSRs were found in all genomic regions although they are more frequent in non-coding regions (introns and intergenic regions). Sixty out of 135 PCR-amplified mono-, di-, tri-, tetra, penta, and hexanucleotides were polymorphic (44%) within black truffle populations and 27 were randomly selected and analysed on 139 T. melanosporum isolates from France, Italy and Spain. The number of alleles varied from 2 to 18 and the expected heterozygosity from 0.124 to 0.815. One hundred and thirty-two different multilocus genotypes out of the 139 T. melanosporum isolates were identified and the genotypic diversity was high (0.999). Polymorphic SSRs were found in UTR regulatory regions of fruiting bodies and ectomycorrhiza regulated genes, suggesting that they may play a role in phenotypic variation. In conclusion, SSRs developed in this study were highly polymorphic and our results showed that T. melanosporum is a species with an important genetic diversity, which is in agreement with its recently uncovered heterothallic mating system.

Murat, Claude [INRA, Nancy, France; Riccioni, C [INRA, Nancy, France; Belfiori, B [INRA, Nancy, France; Cichocki, N [INRA, Nancy, France; Labbe, Jessy L [ORNL; Morin, Emmanuelle [INRA, Nancy, France; Tisserant, Emilie [INRA, Nancy, France; Paolocci, F [INRA, Nancy, France; Rubini, A [INRA, Nancy, France; Martin, Francis [INRA, Nancy, France

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

2K09 and thereafter : the coming era of integrative bioinformatics, systems biology and intelligent computing for functional genomics and personalized medicine research  

E-Print Network (OSTI)

acid interactions on systems biology studies (http://and computational molecular biology studies Xu et. al. [9]the Institute for Digital Biology and Hearin Distinguished

2010-01-01T23:59:59.000Z

102

Huckleberry Biology  

NLE Websites -- All DOE Office Websites (Extended Search)

Huckleberry Biology Name: Katarina Location: NA Country: NA Date: NA Question: Where are huckleberries grown in Illionois and New Jersey? Do you know the names of farms and...

103

Molecular Communication for Nanomachines Using Intercellular Calcium Signaling  

E-Print Network (OSTI)

Molecular Communication for Nanomachines Using Intercellular Calcium Signaling Tadashi Nakano, Irvine, Irvine, CA 92697, USA Abstract -- Molecular communication is engineered biological communication the design of a molecular communication system based on intercellular calcium signaling networks. This paper

Baykal, Buyurman

104

Gars Biology  

NLE Websites -- All DOE Office Websites (Extended Search)

Gars Biology Name: ryan Location: NA Country: NA Date: NA Question: what kind of fish is a gar? where it lives(fresh or salt water)? what does it eat? what is its protection? is...

105

Easy biology?  

NLE Websites -- All DOE Office Websites (Extended Search)

Easy biology? Name: bobber Status: NA Age: NA Location: NA Country: NA Date: Around 1993 Question: I am a freshman in high school. Although I am not taking science this year, I...

106

Hummingbird Biology  

NLE Websites -- All DOE Office Websites (Extended Search)

Hummingbird Biology Name: Carrie Location: NA Country: NA Date: NA Question: I am interested in the eggs of hummingbirds. We ate at the YMCA of the Ozarks today and they have...

107

Assessing computational methods and science policy in systems biology  

E-Print Network (OSTI)

In this thesis, I discuss the development of systems biology and issues in the progression of this science discipline. Traditional molecular biology has been driven by reductionism with the belief that breaking down a ...

Castillo, Andrea R. (Andrea Redwing)

2009-01-01T23:59:59.000Z

108

BNL | Computational Biology & Bioinformatics  

NLE Websites -- All DOE Office Websites (Extended Search)

Computational Biology & Bioinformatics Computational Biology and Bioinformatics groups focuses on quantitative predictive models of complex biological systems and their underlying...

109

EMSL: Science: GC: Membrane Biology - Presentations and Awards  

NLE Websites -- All DOE Office Websites (Extended Search)

of ABC Transporters." Presented by Nicole Koropatkin at 9th Cyanobacterial Molecular Biology Workshop, Lake Delavan, WI on June 6, 2007. Koppenaal DW, and CJ Barinaga. 2005....

110

EMSL: Science: GC: Membrane Biology - Advisory Committee  

NLE Websites -- All DOE Office Websites (Extended Search)

Advisory Committee CHAIR - Dr. Jack Johnson, SCRIPPS Department of Molecular Biology 10550, N. Torrey Pines Road La Jolla, CA 92037 Ph. 858-784-2947 Fx. 858-784-8660...

111

DEPARTMENT OF CELL AND MOLECULAR BIOLOGY  

E-Print Network (OSTI)

and completion of a degree in a timely manner. Be sure to stop at the Advisement Office (WHAM 122) and pick up Services Academic Advisors Bob Simpson Chief Academic Advisor (e-mail: bobbo@siu.edu) Wham Building, Room 122 (Ph. 618-453-6340) Chief Academic Advisor Natalie Branca (e-mail: nbranca@siu.edu Wham Building

Uppsala Universitet

112

Molecular Biomimetics Enables Biological Materials Science and ...  

Science Conference Proceedings (OSTI)

Microwave Augmented Fabrication and Evaluation of CNT-Reinforced Nanohydroxyapatite Mimicking Bone Formation Using Anionic Polymeric...

113

The Molecular Foundry - Biological Nanostructures - Staff Publications  

NLE Websites -- All DOE Office Websites (Extended Search)

B. Cohen, B. Helms, D. Milliron, "Driving Oxygen Coordinated Ligand Exchange at Nanocrystal Surfaces Using Trialkylsilylated Chalcogenides," Chemical Communications, 47,...

114

The Molecular Foundry - Biological Nanostructures - Staff  

NLE Websites -- All DOE Office Websites (Extended Search)

510.486.6907 Alexis Ostrowski, Postdoc, adostrowski@lbl.gov, 510.486.6907 Behzad Rad, Postdoc, brad@lbl.gov, 510.486.6907 Seong-Ho Shin, Postdoc, shshin@lbl.gov,...

115

The Molecular Foundry - Biological Nanostructures - Staff - Bruce...  

NLE Websites -- All DOE Office Websites (Extended Search)

lanthanide-doped nanocrystals. PNAS 106 10917-10921 (2009). G. Han, T. Mokari, C. Ajo-Franklin, B.E. Cohen. Caged quantum dots. J. Am. Chem. Soc. 130, 15811-15813 (2008). J.S....

116

The Molecular Foundry - Biological Nanostructures - Staff Publications  

NLE Websites -- All DOE Office Websites (Extended Search)

on surfaces." J. Phys. Chem. B 112, 15103 (2008). pdf G. Han, T. Mokari, C. Ajo-Franklin and B. Cohen, "Caged Quantum Dots", J. Am. Chem. Soc., 130 (47), 15811-15813...

117

The Molecular Foundry - Biological Nanostructures - User Publications  

NLE Websites -- All DOE Office Websites (Extended Search)

networks", Proc. Natl. Acad. Sci. USA 108, 8617 (2011). pdf R. Armstrong and J. Ajo-Franklin. "Investigating biomineralization using synchrotron based X-ray computed...

118

The Molecular Foundry - Biological Nanostructures - User Publications  

NLE Websites -- All DOE Office Websites (Extended Search)

Biophysical Journal 104 197a (2013). DOI: 10.1016j.bpj.2012.11.1111 pdf C. M. Ajo-Franklin, C. E. Korman, D. A. Horsley, and M. Megens, "Nanopore-Spanning Lipid Bilayers on...

119

Molecular and Systems Biology | Biosciences Division  

NLE Websites -- All DOE Office Websites (Extended Search)

Crystallization Trials BIO Home Page About BIO News Releases Research Publications People Contact Us Organization Chart Site Index Inside BIO BIO Safety About Argonne Cancer...

120

Molecular and Systems Biology | Biosciences Division  

NLE Websites -- All DOE Office Websites (Extended Search)

Protocols BIO Home Page About BIO News Releases Research Publications People Contact Us Organization Chart Site Index Inside BIO BIO Safety About Argonne Cancer Protein Biomarkers...

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Molecular and Systems Biology | Biosciences Division  

NLE Websites -- All DOE Office Websites (Extended Search)

Publications BIO Home Page About BIO News Releases Research Publications People Contact Us Organization Chart Site Index Inside BIO BIO Safety About Argonne Cancer Protein...

122

Molecular and Systems Biology | Biosciences Division  

NLE Websites -- All DOE Office Websites (Extended Search)

Clinical Proteomics and Biomarker Discovery BIO Home Page About BIO News Releases Research Publications People Contact Us Organization Chart Site Index Inside BIO BIO Safety About...

123

Molecular and Systems Biology | Biosciences Division  

NLE Websites -- All DOE Office Websites (Extended Search)

Analysis BIO Home Page About BIO News Releases Research Publications People Contact Us Organization Chart Site Index Inside BIO BIO Safety About Argonne Cancer Protein Biomarkers...

124

Integrated Omics in Systems Biology: The New Frontier for Environmental Biotechnology  

E-Print Network (OSTI)

community. Molecular Systems Biology 3:92 250M H 2 O 2 0pipelines for systems biology ? Integrated data capture,devices, chassis for synthetic biology Comparative Genomics

Hazen, Terry C.

2008-01-01T23:59:59.000Z

125

Systems biology analysis of Escherichia coli for discovery and metabolic engineering  

E-Print Network (OSTI)

the unification of biology. The Gene Ontology Consortium.cellular and molecular biology. 2nd ed. 1996, ASM Press:Journal of Theoretical Biology, 1993. 165(4): p. 503- Feist,

Orth, Jeffrey David

2012-01-01T23:59:59.000Z

126

Model-driven metabolic engineering of Escherichia coli : a systems biology approach  

E-Print Network (OSTI)

cellular and molecular biology. Washington, D.C. : ASMmodels in microbial systems biology. Curr Opin Microbiol 3.12 (iJR904 GSM/GPR). Genome Biology 2003;4:R54.1-R54.12. 14.

Feist, Adam Michael

2008-01-01T23:59:59.000Z

127

Biological preconcentrator  

DOE Patents (OSTI)

A biological preconcentrator comprises a stimulus-responsive active film on a stimulus-producing microfabricated platform. The active film can comprise a thermally switchable polymer film that can be used to selectively absorb and desorb proteins from a protein mixture. The biological microfabricated platform can comprise a thin membrane suspended on a substrate with an integral resistive heater and/or thermoelectric cooler for thermal switching of the active polymer film disposed on the membrane. The active polymer film can comprise hydrogel-like polymers, such as poly(ethylene oxide) or poly(n-isopropylacrylamide), that are tethered to the membrane. The biological preconcentrator can be fabricated with semiconductor materials and technologies.

Manginell, Ronald P. (Albuquerque, NM); Bunker, Bruce C. (Albuquerque, NM); Huber, Dale L. (Albuquerque, NM)

2008-09-09T23:59:59.000Z

128

Responses of Cell Renewal Systems to Long-term Low-Level Radiation Exposure: A Feasibility Study Applying Advanced Molecular Biology Techniques on Available Histological and Cytological Material of Exposed Animals and Men  

SciTech Connect

First results of this feasibility study showed that evaluation of the stored material of the chronically irradiated dogs with modern molecular biological techniques proved to be successful and extremely promising. Therefore an in deep analysis of at least part of the huge amount of remaining material is of outmost interest. The methods applied in this feasibility study were pathological evaluation with different staining methods, protein analysis by means of immunohistochemistry, strand break analysis with the TdT-assay, DNA- and RNA-analysis as well as genomic examination by gene array. Overall more than 50% of the investigated material could be used. In particular the results of an increased stimulation of the immune system within the dogs of the 3mSv group as both compared to the control and higher dose groups gives implications for the in depth study of the cellular events occurring in context with low dose radiation. Based on the findings of this study a further evaluation and statistically analysis of more material can help to identify promising biomarkers for low dose radiation. A systematic evaluation of a correlation of dose rates and strand breaks within the dog tissue might moreover help to explain mechanisms of tolerance to IR. One central problem is that most sequences for dog specific primers are not known yet. The discovery of the dog genome is still under progress. In this study the isolation of RNA within the dog tissue was successful. But up to now there are no gene arrays or gene chips commercially available, tested and adapted for canine tissue. The uncritical use of untested genomic test systems for canine tissue seems to be ineffective at the moment, time consuming and ineffective. Next steps in the investigation of genomic changes after IR within the stored dog tissue should be limited to quantitative RT-PCR of tested primer sequences for the dog. A collaboration with institutions working in the field of the discovery of the dog genome could have synergistic effects.

Fliedner Theodor M.; Feinendegen Ludwig E.; Meineke Viktor; Fritz Thomas E.

2005-02-28T23:59:59.000Z

129

Quantum physics meets biology  

E-Print Network (OSTI)

Quantum physics and biology have long been regarded as unrelated disciplines, describing nature at the inanimate microlevel on the one hand and living species on the other hand. Over the last decades the life sciences have succeeded in providing ever more and refined explanations of macroscopic phenomena that were based on an improved understanding of molecular structures and mechanisms. Simultaneously, quantum physics, originally rooted in a world view of quantum coherences, entanglement and other non-classical effects, has been heading towards systems of increasing complexity. The present perspective article shall serve as a pedestrian guide to the growing interconnections between the two fields. We recapitulate the generic and sometimes unintuitive characteristics of quantum physics and point to a number of applications in the life sciences. We discuss our criteria for a future quantum biology, its current status, recent experimental progress and also the restrictions that nature imposes on bold extrapolations of quantum theory to macroscopic phenomena.

Markus Arndt; Thomas Juffmann; Vlatko Vedral

2009-11-01T23:59:59.000Z

130

Biological Evaluation  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Biological Evaluation Biological Evaluation for the Proposed United States Army Military Training Activities on the Savannah River Site Department of the Army - Fort Gordon Range Control - Directorate of Plans, Training, Mobilization, and Security Location: Aiken, Allendale, and Barnwell Counties, SC., Savannah River Site Contact Person: Donald S. McLean, 706-840-5522 / 706-791-2422 Submitted by Fort Gordon Range Control Training Facility Coordinator (DPTMS) Prepared By: ___________________________________________________________________ Donald S. McLean, Training Facility Coordinator Fort Gordon Georgia Date: 2 Table of Contents Summary, Page 4 Introduction, Page 6 Project Description, Page 6 Purpose and Need for Proposed Action, Page 7

131

Biological clock  

NLE Websites -- All DOE Office Websites (Extended Search)

Biological clock Biological clock Name: N/A Location: N/A Country: N/A Date: N/A Question: How does a person's biological clock work? Replies: I believe there's a region or gland in the brain that regulates biological clocks. This region or gland senses the environment's day/night cycle. I'm afraid I don't know much more than that. Hope this helps. --- jade No one knows for sure how any circadian (nearly 24 hour-in Latin) clock works. Some interesting facts, though. The pineal gland in the brain is important. Although shifting the day-night cycle can shift the clock, the clock runs on its own without any dark-light cues. So it seems to be a natural chemical clock with a cycle nearly, but not exactly at 24 hours, which is entrained by the 24 hour day-night cycle. There are neurons in lower animals which can be kept alive alone, isolate from the nervous system and from any light-dark cues, that show electrical activity on a near-24-hours cycle

132

Ninth International Workshop on Plant Membrane Biology  

SciTech Connect

This report is a compilation of abstracts from papers which were discussed at a workshop on plant membrane biology. Topics include: plasma membrane ATP-ases; plant-environment interactions, membrane receptors; signal transduction; ion channel physiology; biophysics and molecular biology; vaculor H+ pumps; sugar carriers; membrane transport; and cellular structure and function.

Not Available

1993-12-31T23:59:59.000Z

133

Michael Levitt and Computational Biology  

Office of Scientific and Technical Information (OSTI)

Michael Levitt and Computational Biology Michael Levitt and Computational Biology Resources with Additional Information · Publications Michael Levitt Courtesy of Linda A. Cicero / Stanford News Service Michael Levitt, PhD, professor of structural biology at the Stanford University School of Medicine, has won the 2013 Nobel Prize in Chemistry. ... Levitt ... shares the ... prize with Martin Karplus ... and Arieh Warshel ... "for the development of multiscale models for complex chemical systems." Levitt's work focuses on theoretical, computer-aided analysis of protein, DNA and RNA molecules responsible for life at its most fundamental level. Delineating the precise molecular structures of biological molecules is a necessary first step in understanding how they work and in designing drugs to alter their function. ...

134

Grasshopper Biology  

NLE Websites -- All DOE Office Websites (Extended Search)

Grasshopper Biology Grasshopper Biology Name: s. Location: N/A Country: N/A Date: N/A Question: My son found a grasshopper and put it in a fish bowl with cover, and we need to know what to feed it? we have it some lettuce and apple and a bit of water. Replies: Sounds ok so far, most any kind of green plant should be ok, doubt it will pay too much attention to the water. Don't expect it to live very long though. J. Elliott Hello, Grasshoppers eat green vegetation of various kinds. They especially love tall grass. The greener the better. Clip a variety of plants from a nearby unmowed ditch or vacant lot and place them in a short container of water and place the container of water and plants in your fish bowl. The grasshopper will "eat it up". Wayne Vanderploeg River Trail Nature Center

135

Anton, a special-purpose machine for molecular dynamics simulation  

Science Conference Proceedings (OSTI)

The ability to perform long, accurate molecular dynamics (MD) simulations involving proteins and other biological macro-molecules could in principle provide answers to some of the most important currently outstanding questions in the fields of biology, ... Keywords: bioinformatics, biomolecular system simulation, computational biology, computational drug design, molecular dynamics, protein folding, protein structure, special-purpose machine

David E. Shaw; Martin M. Deneroff; Ron O. Dror; Jeffrey S. Kuskin; Richard H. Larson; John K. Salmon; Cliff Young; Brannon Batson; Kevin J. Bowers; Jack C. Chao; Michael P. Eastwood; Joseph Gagliardo; J. P. Grossman; C. Richard Ho; Douglas J. Ierardi; Istvn Kolossvry; John L. Klepeis; Timothy Layman; Christine McLeavey; Mark A. Moraes; Rolf Mueller; Edward C. Priest; Yibing Shan; Jochen Spengler; Michael Theobald; Brian Towles; Stanley C. Wang

2007-06-01T23:59:59.000Z

136

Brookhaven Symposium Biology 32  

NLE Websites -- All DOE Office Websites (Extended Search)

Symposium Biology 32 Symposium Biology 32 Brookhaven National Laboratory, June 1-4, 1982 NEUTRONS IN BIOLOGY, B. Schoenborn, Plenum Press N Y BNL--34681 DE84 012174 NOTICE p _ THIS R£PORT IS l £ - T . l - : T = "-T-**: TO A DEGHES THAT PRECLUDES SA u^.-.iA OKV REPRODUCTION NEUTRON SCATTERING AND THE 3 0 S RI3CS0MAL SUBUNIT OF j ^ . COLI P.B. Moore, a D.M. Enselmsn, b J.A. Langer, b V.R. Ramaicrishnan,^ _.G« Schindler, 3 B.P. Schoenborn, c I-Y. Sillers, a and S. Yabuki a a Uept. of Chemistry and ^Molecular Biophysics and Biochemistry Yale University. Nev Haven, CT 06511 c BicIogy Dapc, Srookhavse National Lab., Upton, NY 11973 INTRODUCTION Siboscmes ara nueleoprotein enzyaes which catalyze the for- mation of polypeptide chains under inRNA control, using aminoacyl tENAs as substrates-for reviawo see Nomura et al. (22) and

137

Biology reflective assessment curriculum  

E-Print Network (OSTI)

Penick, J. E. (1998). Biology: A community context. Newof a standards-based high school biology curriculum.The American Biology Teacher Li, J. , Klahr, D. , & Siler,

Bayley, Cheryl Ann

2011-01-01T23:59:59.000Z

138

Biology at Berkeley  

E-Print Network (OSTI)

Paper Series Martin Trow, BIOLOGY AT BERKELEY BibliographyCalifornia, Berkeley. Internal Biology Review Committee. (ishi.lib.berkeley.edu/cshe/ BIOLOGY AT BERKELEY: A Case

Trow, Martin A

1999-01-01T23:59:59.000Z

139

J. Math. Biol. DOI 10.1007/s00285-006-0043-9 Mathematical Biology Mathematical and theoretical biology for systems biology, and then...vice versa  

E-Print Network (OSTI)

Systems Biology has two roots (1). The better known resides in Molecular Biology, grew to functional genomics and then became top-down, genomewide Systems Biology. The less-publicized root resides in theoretical and Mathematical Biology, with topics such as non-equilibrium thermodynamics, self-organization, kinetic modelling, metabolic control analysis, flux analysis and biochemical systems theory, culminating in genome-wide versions thereof. It is anticipated that from these roots a Biology of unprecedented strength and quality will emerge, which ends the deadlocks of functional genomics drowning in its oceans of data and of Mathematical Biology escaping reality. Much of the growth in Systems Biology has bypassed Mathematical and Theoretical Biology. Only at the 2005 ESMTB meeting in Dresden did the surge in Systems Biology activity seen in molecular cell biology, begin to be mirrored by a similar surge in Mathematical Biology. Until then, the more theoretical activities in Systems Biology involved engineers much more than mathematicians. Why has this been the case? Systems Biology is well-defined and broad at the same time, not unlike Mathematical Biology. It is the science that studies how functional biological properties arise in the interactions of components (2,

Hans V. Westerhoff; H. V. Westerhoff (b

2006-01-01T23:59:59.000Z

140

Systems biology approach to bioremediation  

Science Conference Proceedings (OSTI)

Bioremediation has historically been approached as a ?black box? in terms of our fundamental understanding. Thus it succeeds and fails, seldom without a complete understanding of why. Systems biology is an integrated research approach to study complex biological systems, by investigating interactions and networks at the molecular, cellular, community, and ecosystem level. The knowledge of these interactions within individual components is fundamental to understanding the dynamics of the ecosystem under investigation. Understanding and modeling functional microbial community structure and stress responses in environments at all levels have tremendous implications for our fundamental understanding of hydrobiogeochemical processes and the potential for making bioremediation breakthroughs and illuminating the ?black box?.

Chakraborty, R.; Wu, C. H.; Hazen, T. C.

2012-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Systems Biology | Clean Energy | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

Bioenergy Biological Interfaces Computational Biology and KBase Environmental Biology Genomic Sciences Structural Biology Collaborative University Research Transportation Clean...

142

Biological Science  

NLE Websites -- All DOE Office Websites (Extended Search)

Biological Science Biological Science A unique zinc-binding site revealed by the high-resolution x-ray structure of homotrimeric Apo2L/TRAIL S.G. Hymowitz, M.P. O'Connell, M.H. Ultsch, A. Hurst, K. Totpal, A. Ashkenazi, R.F. Kelley, and A.M. de Vos b-carbonic anhydrase active site architecture is a mirror image of a-carbonic anhydrases E.F. Pai and M.S. Kimber Binding of Cd ions to the cell wall of B. Subtilis - an EXAFS study M. Boyanov, D. Fowle, K. Kemner, B. Bunker, and J. Fein Crystallographic evidence for Try157 functioning as the active site base in human UDP-galactose 4-epimerase J.B. Thoden, T.M. Wohlers, J.L. Fridovich-Keil, and H.M. Holden Crystallographic studies of dsDNA phage HK97 structure and maturation W.R. Wikoff, Z. Che, W. Schildkamp, L. Liljas, R.L. Duda, R.W. Hendrix, and

143

MOLECULAR AND CELLULAR BIOLOGY, June 2004, p. 52495256 Vol. 24, No. 12 0270-7306/04/$08.00 0 DOI: 10.1128/MCB.24.12.52495256.2004  

E-Print Network (OSTI)

at Austin, Austin, Texas 78712-01592 Received 7 November 2003/Returned for modification 26 January 2004 of biological functions including protein folding and degradation, energy generation, protein trafficking

Iyer, Vishy

144

Molecular Mechanism Underlying Cellular Response in 3D Skin to...  

NLE Websites -- All DOE Office Websites (Extended Search)

biological response. At PNNL we are applying a system biology approach to identify molecular targets in complex human tissue exposed to low-dose ionizing radiation. Our goal is...

145

Anton, a special-purpose machine for molecular dynamics simulation  

Science Conference Proceedings (OSTI)

The ability to perform long, accurate molecular dynamics (MD) simulations involving proteins and other biological macro-molecules could in principle provide answers to some of the most important currently outstanding questions in the fields of biology, ...

David E. Shaw; Martin M. Deneroff; Ron O. Dror; Jeffrey S. Kuskin; Richard H. Larson; John K. Salmon; Cliff Young; Brannon Batson; Kevin J. Bowers; Jack C. Chao; Michael P. Eastwood; Joseph Gagliardo; J. P. Grossman; C. Richard Ho; Douglas J. Ierardi; Istvn Kolossvry; John L. Klepeis; Timothy Layman; Christine McLeavey; Mark A. Moraes; Rolf Mueller; Edward C. Priest; Yibing Shan; Jochen Spengler; Michael Theobald; Brian Towles; Stanley C. Wang

2008-07-01T23:59:59.000Z

146

Biology | More Science | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

Bioinformatics Nuclear Medicine Climate and Environment Systems Biology Computational Biology Chemistry Engineering Computer Science Earth and Atmospheric Sciences Materials...

147

BMC Systems Biology BioMed Central Commentary Models for synthetic biology  

E-Print Network (OSTI)

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Synthetic biological engineering is emerging from biology as a distinct discipline based on quantification. The technologies propelling synthetic biology are not new, nor is the concept of designing novel biological molecules. What is new is the emphasis on system behavior. The objective is the design and construction of new biological devices and systems to deliver useful applications. Numerous synthetic gene circuits have been created in the past decade, including bistable switches, oscillators, and logic gates, and possible applications abound, including biofuels, detectors for biochemical and chemical weapons, disease diagnosis, and gene therapies. More than fifty years after the discovery of the molecular structure of DNA, molecular biology is mature enough for real quantification that is useful for biological engineering applications, similar to the revolution in modeling in chemistry in the 1950s. With the excitement that synthetic biology is generating, the engineering and biological science communities appear remarkably willing to cross disciplinary boundaries toward a common goal. Synthetic biological engineering is emerging from biology

Yiannis N Kaznessis

2007-01-01T23:59:59.000Z

148

(Computational) synthetic biology  

Science Conference Proceedings (OSTI)

The ultimate goal of systems biology is the development of executable in silico models of cells and organisms. Systems biology attempts to provide an integrative methodology, which while able to cope with -on the one hand- the data deluge that is being ... Keywords: algorithmic systems biology, executable biology, infobiotics, p systems, synthetic biology, systems biology

Natalio Krasnogor

2011-07-01T23:59:59.000Z

149

Molecular markers for yellow stem borer

Science Conference Proceedings (OSTI)

Plant Molecular Biology, Tamil Nadu Agricultural University, Coimbatore 641 003, India;. ?. Author for correspondence; e-mail: selviathiappan@yahoo.co.in.

150

Magnetismo Molecular (Molecular Magentism)  

SciTech Connect

The new synthesis processes in chemistry open a new world of research, new and surprising materials never before found in nature can now be synthesized and, as a wonderful result, observed a series of physical phenomena never before imagined. Among these are many new materials the molecular magnets, the subject of this book and magnetic properties that are often reflections of the quantum behavior of these materials. Aside from the wonderful experience of exploring something new, the theoretical models that describe the behavior these magnetic materials are, in most cases, soluble analytically, which allows us to know in detail the physical mechanisms governing these materials. Still, the academic interest in parallel this subject, these materials have a number of properties that are promising to be used in technological devices, such as in computers quantum magnetic recording, magnetocaloric effect, spintronics and many other devices. This volume will journey through the world of molecular magnets, from the structural description of these materials to state of the art research.

Reis, Mario S [Universidade Federal Fluminense, Brasil; Moreira Dos Santos, Antonio F [ORNL

2010-07-01T23:59:59.000Z

151

Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

The People of the Molecular Foundry In addition to state-of-the-art instrumentation, Users at the Molecular Foundry benefit from the unique in-house expertise of its researchers....

152

Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

The Molecular Foundry The Molecular Foundry Lawrence Berkeley National Laboratory One Cyclotron Road Building 67 Berkeley, CA 94720 Screen reader users: click here for plain HTML Go to Google Maps Home Molecular Foundry, Berkeley, CA Loading... Map Sat Ter Did you mean a different: Did you mean a different: Did you mean a different: Add Destination - Show options Hide options Get Directions Note: Public transit coverage may not be available in this area. Molecular Foundry, Berkeley, CA A Molecular Foundry 67 Cyclotron Rd, Berkeley, CA ‎ foundry.lbl.gov 3 reviews · "Berkeley Lab. About the Foundry. What is the Molecular Foundry? Research Themes; Foundry Careers; Media Gallery; Other User Facilities external link; Contact Us" - lbl.gov Directions Search nearby more See all 14 results for Molecular Foundry, Berkeley, CA

153

Yann Chevolot (ed.), Carbohydrate Microarrays: Methods and Protocols, Methods in Molecular Biology, vol. 808, DOI 10.1007/978-1-61779-373-8_22, Springer Science+Business Media, LLC 2012  

E-Print Network (OSTI)

% ethanol with 13 mL of water. 16. Microgrid II (Biorobotics; Cambridge, UK) or other suitable arrayer. 2 by the average molecular weight of the GAG. 1. These instructions assume the use of a Microgrid II arrayer EOLs to the computer that operates the Microgrid II Arrayer. Open the TAS application suite program

Stoltz, Brian M.

154

Splicing bioinformatics to biology  

E-Print Network (OSTI)

Splicing bioinformatics to biology Douglas L Black* andand Developmental Biology, University of Connecticut Health26 May 2006 Genome Biology 2006, 7:317 (doi:10.1186/gb-2006-

Black, Douglas L; Graveley, Brenton R

2006-01-01T23:59:59.000Z

155

BioJADE: A Design and Simulation Tool for Synthetic Biological Systems  

E-Print Network (OSTI)

The next generations of both biological engineering and computer engineering demand that control be exerted at the molecular level. Creating, characterizing and controlling synthetic biological systems may provide us ...

Goler, Jonathan A.

2004-05-28T23:59:59.000Z

156

Healthcare & Biology Licenses Available | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

Healthcare and Biology Healthcare and Biology SHARE Healthcare and Biology 200000830 Monolythic Analyte Concentrator and Separator for Cantilever Sensors 200000838 Nanoscale Photonic Spectrometer 200000846 Hybrid Valve System for Fluid Handling 200000870 Microwave Thawing Apparatus and Method 200000872 Package for Microwave- Assisted Thawing and Method for Use 200000894 Physical Sequencing - A Novel Method of Sequencing Nucleic Acids 200100901 Spherical Ferrite Bead and Method of Making 200100913 Automated Soil Gas Monitoring Chamber 200100927 Photoelectrochemical Molecular Comb 200100942 Succinic Acid Producing E. coli Strain 200100943 DNA and RNA Sequencing by Nanoscale Reading Through Programmable Electrophoresis and Nanoelectrode-Gated Tunneling and Dielectric Detection

157

Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

Biological Nanostructures Biological Nanostructures This facility studies the synthesis, analysis and mimicry of biological nanostructures. Expertise and capabilities are available to develop new materials based on the folding and assembly of sequence-defined, bioinspired polymers (including peptides,,nucleic acids, and peptoids). New biocompatible imaging probes based on organic dyes and functionalized inorganic nanocrystals are being developed and are available to facilitate state-of-the-art bioimaging studies. Synthetic biology techniques are used to re-engineer organisms and create hybrid biomolecules to interface with devices. Additional capabilities include synthesis, purification and characterization of bio- and biomimetic polymers, bioconjugation, and combinatorial peptide and peptoid library synthesis and screening. Protein

158

Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

deposition, and characterization, emphasizing integration with chemical and biological nano-systems and the development of nano-electronic, nano-magnetic, and nano-photonic...

159

Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

to advance research ranging from biology, medicine and engineering to electronics and photonics. If you believe that your research would benefit from or enhance knowledge at the...

160

Molecular Foundry  

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Biological Nanostructures Staff Ron Zuckerman Ron Zuckermann Facility Director rnzuckermann@lbl.gov 510.486.7091 Caroline Ajo-Franklin Caroline Ajo-Franklin Staff Scientist...

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
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161

Evaluation of Fitness and Genetic Variation in Aphytis melinus DeBach, an Important Biological Control Agent of Aonidiella aurantii (Maskell) in California  

E-Print Network (OSTI)

Molecular Biology 7, 393-396. Grenier, S. , Gomes, S. M. ,no difference in fecundity ( Grenier et al. , 2002) or

Vasquez, Casandra Jean

2010-01-01T23:59:59.000Z

162

Structural Biology | Biosciences Division  

NLE Websites -- All DOE Office Websites (Extended Search)

Biology BIO Home Page About BIO News Releases Research Publications People Contact Us Organization Chart Site Index Inside BIO BIO Safety About Argonne Structural Biology The...

163

Computational Biology | Supercomputing & Computation | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

Home | Science & Discovery | Supercomputing and Computation | Research Areas | Biology SHARE Computational Biology Computational Biology research encompasses many important...

164

BE.440 Analysis of Biological Networks, Fall 2004  

E-Print Network (OSTI)

This class analyzes complex biological processes from the molecular, cellular, extracellular, and organ levels of hierarchy. Emphasis is placed on the basic biochemical and biophysical principles that govern these processes. ...

Essigmann, John

165

Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

SEMINARS ARCHIVE The Molecular Foundry regularly offers seminars and events that feature compelling research and information for those who investigate at the nanoscale. Seminars...

166

Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

EVENTS ARCHIVE The Molecular Foundry regularly offers seminars and events that feature compelling research and information for those who investigate at the nanoscale. Seminars...

167

Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

efficient energy storage and conversion. Electron donors and acceptors at interfaces Molecular level design and synthesis has created tailor-made electron donors and acceptors...

168

Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

Careers Information about current openings at the Molecular Foundry and complete application information is available from LBNL Human Resources. Please follow the application...

169

Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

the Future, Atom by Atom Organized into six interdependent research Facilities, The Molecular Foundry, along with Berkeley Lab's additional User programs and affiliated research...

170

Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

Sign-Up (Resource Database) Weekly Seminars Users' Executive Committee (UEC) The Molecular Foundry Users' Association is composed of all Foundry Users. Upon beginning work on...

171

Molecular Foundry  

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Management Code of Conduct Conflict Resolution Beginning your project Access to the Molecular Foundry is free of charge for approved, non-proprietary research. (Proprietary...

172

Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

SEMINARS The Molecular Foundry regularly offers seminars and events that feature compelling research and information for those who investigate at the nanoscale. Seminars occur on...

173

Physics Meets Biology (LBNL Summer Lecture Series)  

Science Conference Proceedings (OSTI)

Summer Lecture Series 2006: If scientists could take advantage of the awesomely complex and beautiful functioning of biologys natural molecular machines, their potential for application in many disciplines would be incalculable. Nobel Laureate and Director of the Lawrence Berkeley National Laboratory Steve Chu explores Possible solutions to global warming and its consequences.

Chu, Steve (Director, LBNL)

2006-07-01T23:59:59.000Z

174

Molecular Biomechanics: The Molecular Basis of How Forces Regulate Cellular Function  

E-Print Network (OSTI)

Recent advances have led to the emergence of molecular biomechanics as an essential element of modern biology. These efforts focus on theoretical and experimental studies of the mechanics of proteins and nucleic acids, and ...

Bao, Gang

175

Continuum Electrostatics in Cell Biology  

E-Print Network (OSTI)

Recent experiments revealing possible nanoscale electrostatic interactions in force generation at kinetochores for chromosome motions have prompted speculation regarding possible models for interactions between positively charged molecules in kinetochores and negative charge on C-termini near the plus ends of microtubules. A clear picture of how kinetochores establish and maintain a dynamic coupling to microtubules for force generation during the complex motions of mitosis remains elusive. The current paradigm of molecular cell biology requires that specific molecules, or molecular geometries, for force generation be identified. However, it is possible to account for mitotic motions within a classical electrostatics approach in terms of experimentally known cellular electric charge interacting over nanometer distances. These charges are modeled as bound surface and volume continuum charge distributions. Electrostatic consequences of intracellular pH changes during mitosis may provide a master clock for the events of mitosis.

L. John Gagliardi

2010-02-06T23:59:59.000Z

176

Electrostatic correlations: from Plasma to Biology  

E-Print Network (OSTI)

Electrostatic correlations play an important role in physics, chemistry and biology. In plasmas they lead to thermodynamic instability similar to the liquid-gas phase transition of simple molecular fluids. For charged colloidal suspensions the electrostatic correlations are responsible for screening and colloidal charge renormalization. In aqueous solutions containing multivalent counterions they can lead to charge inversion and flocculation. In biological systems the correlations account for the organization of cytoskeleton and the compaction of genetic material. In spite of their ubiquity, the true importance of electrostatic correlations has become fully appreciated only quite recently. In this paper, I will review the thermodynamic consequences of electrostatic correlations in a variety of systems ranging from classical plasmas to molecular biology.

Yan Levin

2002-07-02T23:59:59.000Z

177

Review: At a glance: Cellular biology for engineers  

Science Conference Proceedings (OSTI)

Engineering contributions have played an important role in the rise and evolution of cellular biology. Engineering technologies have helped biologists to explore the living organisms at cellular and molecular levels, and have created new opportunities ... Keywords: Cell organelles, Cellular biology, Energy generation, Micro-bio-factory, Protein synthesis

K. Khoshmanesh; A. Z. Kouzani; S. Nahavandi; S. Baratchi; J. R. Kanwar

2008-10-01T23:59:59.000Z

178

Chemical Biology Coop Program (New for January 2011) Students from the Chemical Biology Coop Program will be prepared to conduct work terms in areas such as  

E-Print Network (OSTI)

Program will be prepared to conduct work terms in areas such as biosensors, metabolomics, biomimeticsChemical Biology Coop Program (New for January 2011) Students from the Chemical Biology Coop of the Chemical Biology Coop Program: Bioanalytical Chemistry Organic Chemistry & synthesis Cellular & molecular

Hitchcock, Adam P.

179

Molecular nanocomposites.  

Science Conference Proceedings (OSTI)

The goals of this project are to understand the fundamental principles that govern the formation and function of novel nanoscale and nanocomposite materials. Specific scientific issues being addressed include: design and synthesis of complex molecular precursors with controlled architectures, controlled synthesis of nanoclusters and nanoparticles, development of robust two or three-dimensionally ordered nanocomposite materials with integrated functionalities that can respond to internal or external stimuli through specific molecular interactions or phase transitions, fundamental understanding of molecular self-assembly mechanisms on multiple length scales, and fundamental understanding of transport, electronic, optical, magnetic, catalytic and photocatalytic properties derived from the nanoscale phenomena and unique surface and interfacial chemistry for DOE's energy mission.

Voigt, James A.

2010-03-01T23:59:59.000Z

180

PLANT BIOLOGY DEPARTMENT HANDBOOK  

E-Print Network (OSTI)

PLANT BIOLOGY DEPARTMENT HANDBOOK 2012-2013 University of Georgia Athens, GA 30602 Updated: 9/5/12 #12;Plant Biology Handbook Table of Contents General Information and Operating Procedures 1

Arnold, Jonathan

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
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181

2003 Synthetic Biology study  

E-Print Network (OSTI)

Biology is a technology for processing information, materials, and energy. As a technology platform, biological systems provide access to artifacts and processes across a range of scales (e.g., the ribosome is a programmable ...

Endy, Drew

2007-08-14T23:59:59.000Z

182

Biological Production of Hydrogen  

NLE Websites -- All DOE Office Websites (Extended Search)

Biological Techniques Environmental Sampling: Microbial Communities Applications: Algae Ponds Source: Frank Dazzo, Center for Microbial Ecology, Michigan State University...

183

Computational Biology Project  

Science Conference Proceedings (OSTI)

... biological metadata raise questions related to information technology standards ... data/metadata format for image capture, storage, retrieval, analysis; ...

2010-10-05T23:59:59.000Z

184

Biological Interactions and Dynamics  

NLE Websites -- All DOE Office Websites (Extended Search)

State University, Tri-cities, Washington Nitin Baliga, Institute for Systems Biology, Seattle, Washington Jim Frederickson Pacific Northwest National Laboratory,...

185

Molecular fountain.  

SciTech Connect

A molecular fountain directs slowly moving molecules against gravity to further slow them to translational energies that they can be trapped and studied. If the molecules are initially slow enough they will return some time later to the position from which they were launched. Because this round trip time can be on the order of a second a single molecule can be observed for times sufficient to perform Hz level spectroscopy. The goal of this LDRD proposal was to construct a novel Molecular Fountain apparatus capable of producing dilute samples of molecules at near zero temperatures in well-defined user-selectable, quantum states. The slowly moving molecules used in this research are produced by the previously developed Kinematic Cooling technique, which uses a crossed atomic and molecular beam apparatus to generate single rotational level molecular samples moving slowly in the laboratory reference frame. The Kinematic Cooling technique produces cold molecules from a supersonic molecular beam via single collisions with a supersonic atomic beam. A single collision of an atom with a molecule occurring at the correct energy and relative velocity can cause a small fraction of the molecules to move very slowly vertically against gravity in the laboratory. These slowly moving molecules are captured by an electrostatic hexapole guiding field that both orients and focuses the molecules. The molecules are focused into the ionization region of a time-of-flight mass spectrometer and are ionized by laser radiation. The new molecular fountain apparatus was built utilizing a new design for molecular beam apparatus that has allowed us to miniaturize the apparatus. This new design minimizes the volumes and surface area of the machine allowing smaller pumps to maintain the necessary background pressures needed for these experiments.

Strecker, Kevin E.; Chandler, David W.

2009-09-01T23:59:59.000Z

186

Todd Newberry: Professor of Biology  

E-Print Network (OSTI)

Todd Newberry, Professor of Biology: Cowell College page 12Jarrell: Whys that? Todd Newberry, Professor of Biology:Biology Board page 14 Newberry: Well, besides the

Newberry, Andrew Todd; Jarrell, Randall; Regional History Project, UCSC Library

2006-01-01T23:59:59.000Z

187

FGF-23 in bone biology  

E-Print Network (OSTI)

6 REVIEW FGF-23 in bone biology Katherine Wesseling-Perryin impairments in bone biology. Although the defectiveof the protein on bone biology, a growing compendium of data

Wesseling-Perry, Katherine

2010-01-01T23:59:59.000Z

188

Quantitative Imaging in Cell Biology  

E-Print Network (OSTI)

Quantitative! imaging! in! biology! is! concerned! with!Quantitative! imaging! in! biology! is! concerned! with!advances! in! cell! biology! by! enabling! the! tracking!

Yassif, Jaime

2012-01-01T23:59:59.000Z

189

Systems biology approach to bioremediation  

E-Print Network (OSTI)

aspects of the systems biology approach (metagenomics withthe use of a number of sytems biology parameters can revealRL, Banfield JF: Systems Biology: functional analysis of

Chakraborty, R.

2013-01-01T23:59:59.000Z

190

ELECTRON PARAMAGNETIC RESONANCE IN BIOLOGY  

E-Print Network (OSTI)

published in Perspectives in Biology and Medicine. ) 51. D.PARAMAGNETIC RESONANCE IN BIOLOGY G. M. Androes and Melvinparamagnetic resonance in biology is presented, including a

Androes, G.M.; Calvin, Melvin.

2008-01-01T23:59:59.000Z

191

Proposals for Structural Biology Beamlines  

NLE Websites -- All DOE Office Websites (Extended Search)

Proposals for Structural Biology Beamlines Proposals for Structural Biology Beamlines Print Tuesday, 01 June 2010 09:52 Submit a New Proposal for Structural Biology Beamlines...

192

Systems Biology | More Science | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

Systems Biology SHARE Systems Biology Caldicellulosiruptor obsidiansis ORNL research is examining life across scales, from the genome to the environment, to find biological...

193

Proposals for Structural Biology Beamlines  

NLE Websites -- All DOE Office Websites (Extended Search)

Proposals for Structural Biology Beamlines Print Submit a New Proposal for Structural Biology Beamlines Available Beamlines The beamlines suitable for structural biology...

194

Biology and Medicine Division: Annual report 1986  

SciTech Connect

The Biology and Medicine Division continues to make important contributions in scientific areas in which it has a long-established leadership role. For 50 years the Division has pioneered in the application of radioisotopes and charged particles to biology and medicine. There is a growing emphasis on cellular and molecular applications in the work of all the Division's research groups. The powerful tools of genetic engineering, the use of recombinant products, the analytical application of DNA probes, and the use of restriction fragment length polymorphic DNA are described and proposed for increasing use in the future.

Not Available

1987-04-01T23:59:59.000Z

195

Biology and Medicine Division: Annual report 1986  

SciTech Connect

The Biology and Medicine Division continues to make important contributions in scientific areas in which it has a long-established leadership role. For 50 years the Division has pioneered in the application of radioisotopes and charged particles to biology and medicine. There is a growing emphasis on cellular and molecular applications in the work of all the Division's research groups. The powerful tools of genetic engineering, the use of recombinant products, the analytical application of DNA probes, and the use of restriction fragment length polymorphic DNA are described and proposed for increasing use in the future.

1987-04-01T23:59:59.000Z

196

Biological image fusion using a NSCT based variable-weight method  

Science Conference Proceedings (OSTI)

Biological image fusion, as a powerful tool for the protein study, has developed with the advent of various imaging modalities in molecular biology. Combining the fluorescent image and its corresponding phase contrast image will benefit the localization ... Keywords: Biological image fusion, GFP fluorescent image, NSCT, Phase contrast image, Variable weight

Tianjie Li; Yuanyuan Wang

2011-04-01T23:59:59.000Z

197

Belowground Carbon Cycling Processes at the Molecular Scale  

NLE Websites -- All DOE Office Websites (Extended Search)

919 919 Belowground Carbon Cycling Processes at the Molecular Scale An EMSL Science Theme Advisory Panel Workshop Workshop Date: February 19-21, 2013 Prepared for the U.S. Department of Energy's Office of Biological and Environmental Research under Contract DE-AC05-76RL01830 Pacific Northwest National Laboratory Richland, Washington 99352 Belowground Carbon Cycling Processes at the Molecular Scale iii Executive Summary As part of the Belowground Carbon Cycling Processes at the Molecular Scale workshop, an Environmental Molecular

198

An efficient method for the calculation of quantum mechanics/molecular mechanics free energies  

Science Conference Proceedings (OSTI)

The combination of quantum mechanics (QM) with molecular mechanics (MM) offers a route to improved accuracy in the study of biological systems

Christopher J. Woods; Frederick R. Manby; Adrian J. Mulholland

2008-01-01T23:59:59.000Z

199

Biological tracer method  

DOE Patents (OSTI)

The present invention is a biological tracer method for characterizing the movement of a material through a medium, comprising the steps of: introducing a biological tracer comprising a microorganism having ice nucleating activity into a medium; collecting at least one sample of the medium from a point removed from the introduction point; and analyzing the sample for the presence of the biological tracer. The present invention is also a method for using a biological tracer as a label for material identification by introducing a biological tracer having ice nucleating activity into a material, collecting a sample of a portion of the labelled material and analyzing the sample for the presence of the biological tracer. 2 figs.

Strong-Gunderson, J.M.; Palumbo, A.V.

1998-09-15T23:59:59.000Z

200

Biological tracer method  

DOE Patents (OSTI)

The present invention is a biological tracer method for characterizing the movement of a material through a medium, comprising the steps of: introducing a biological tracer comprising a microorganism having ice nucleating activity into a medium; collecting at least one sample of the medium from a point removed from the introduction point; and analyzing the sample for the presence of the biological tracer. The present invention is also a method for using a biological tracer as a label for material identification by introducing a biological tracer having ice nucleating activity into a material, collecting a sample of a portion of the labelled material and analyzing the sample for the presence of the biological tracer.

Strong-Gunderson, Janet M. (Ten Mile, TN); Palumbo, Anthony V. (Oak Ridge, TN)

1998-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
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they are not comprehensive nor are they the most current set.
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201

Biological detector and method  

DOE Patents (OSTI)

A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

Sillerud, Laurel; Alam, Todd M; McDowell, Andrew F

2013-02-26T23:59:59.000Z

202

Genomics and Systems Biology  

NLE Websites -- All DOE Office Websites (Extended Search)

such as energy, agriculture, and environmental cleanup. Get Expertise Babetta Marrone Biofuels Program Manager Email Cheryl Kuske DOE BER Biological System Science Division...

203

Biological Materials Science Symposium  

Science Conference Proceedings (OSTI)

The structure and properties of biological materials exhibit a breadth and complexity .... Protective Role of Arapaima Scales: Structure and Mechanical Behavior.

204

Computational Biology | Biosciences Division  

NLE Websites -- All DOE Office Websites (Extended Search)

Computational Biology BIO Home Page About BIO News Releases Research Publications People Contact Us Organization Chart Site Index Inside BIO BIO Safety About Argonne Computational...

205

Structural Biology | Biosciences Division  

NLE Websites -- All DOE Office Websites (Extended Search)

(NIAID) funded program that applies state-of-the-art high-throughput (HTP) structural biology technologies to experimentally characterize the three dimensional atomic structure of...

206

Genomics and Systems Biology  

NLE Websites -- All DOE Office Websites (Extended Search)

Genomics and Systems Biology LANL leads the world in computational finishing of microbial genomes Read caption + In 2013, Los Alamos scientist Richard Sayre and his team...

207

Structural Biology | Biosciences Division  

NLE Websites -- All DOE Office Websites (Extended Search)

Biosciences Division Argonne National Laboratory Biosciences Division > Structural Biology DOE Logo Search BIO ... Search Argonne Home > BIO home > Membrane Protein Engineering >...

208

Environmental Biology | Biosciences Division  

NLE Websites -- All DOE Office Websites (Extended Search)

Environmental Biology BIO Home Page About BIO News Releases Research Publications People Contact Us Organization Chart Site Index Inside BIO BIO Safety About Argonne Environmental...

209

Complexity in Biology  

E-Print Network (OSTI)

We will review some of the theoretical progresses that have been in the study of complex systems in physics and of their applications to biology.

Giorgio Parisi

1994-12-05T23:59:59.000Z

210

Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

See the Foundry's full equipment list See the Foundry's full equipment list Organic and Macromolecular Synthesis Capabilities & Tools Major Instruments and Capabilities AB SCIEX TF4800 MALDI TOF-TOF Mass Spectrometer This instrument is the tandem time-of-flight mass spectrometer systems, providing the excellent level of molecular mass coverage in the range of molecular masses 500 and 150,000 Da, high throughput, and confidence in both qualitative and quantitative analyses. The analyzer combines all of the advantages of MALDI in a flexible, easy-to-use, ultra-high-performance mass spectrometer with all the advanced capabilities of software. On-axis laser provides high sensitivity to identify and quantitate low-abundance compounds in complex samples. High-resolution precursor ion selection lets

211

Biology and Soft Matter Division | Neutron Science | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

Biology and Soft Matter Division Biology and Soft Matter Division SHARE Biology and Soft Matter Division BSMD Director Paul Langan The Biology and Soft Matter Division (BSMD) operates an external user program for biological and soft matter research using neutron techniques at SNS and HFIR. Division personnel enable the research initiated by external users by acting as instrument responsible scientists and local contacts on a range of different beam lines. BSMD works closely with the Center for Structural Molecular Biology. Diffraction, small-angle scattering, and reflectometry are ideal methods for studying structure and organization from the atomic to the micron length scales, and neutron spectroscopic methods characterize self and collective motions from picosecond to microsecond timescales. These

212

Biology and Soft Matter Division - ORNL Neutron Sciences  

NLE Websites -- All DOE Office Websites (Extended Search)

Home › Neutron Sciences Directorate › Biology and Soft Matter Division Home › Neutron Sciences Directorate › Biology and Soft Matter Division Biology and Soft Matter Division Paul Langan, BSMD Director BSMD Director Paul Langan. The Biology and Soft Matter Division (BSMD) operates an external user program for biological and soft matter research using neutron techniques at SNS and HFIR. Division personnel enable the research initiated by external users by acting as instrument responsible scientists and local contacts on a range of different beam lines. BSMD works closely with the Center for Structural Molecular Biology. Diffraction, small-angle scattering, and reflectometry are ideal methods for studying structure and organization from the atomic to the micron length scales, and neutron spectroscopic methods characterize self and

213

Molecular signatures-based prediction of enzyme promiscuity  

Science Conference Proceedings (OSTI)

Motivation: Enzyme promiscuity, a property with practical applications in biotechnology and synthetic biology, has been related to the evolvability of enzymes. At the molecular level, several structural mechanisms have been linked to enzyme promiscuity ...

Pablo Carbonell; Jean-Loup Faulon

2010-08-01T23:59:59.000Z

214

HST.176 Cellular and Molecular Immunology, Fall 2002  

E-Print Network (OSTI)

Covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation including molecular structure and assembly of ...

Pillai, Shiv

215

Tutorial on biological networks  

Science Conference Proceedings (OSTI)

Understanding how the functioning of a biological system emerges from the interactions among its components is a long-standing goal of network science. Fomented by developments in high-throughput technologies to characterize biomolecules and their interactions, ... Keywords: Biological Data Mining, Data Mining Software Tools, Science and Technology

Francisco G. Vital-Lopez; Vesna Memievi?; Bhaskar Dutta

2012-07-01T23:59:59.000Z

216

Biological sample collector  

DOE Patents (OSTI)

A biological sample collector is adapted to a collect several biological samples in a plurality of filter wells. A biological sample collector may comprise a manifold plate for mounting a filter plate thereon, the filter plate having a plurality of filter wells therein; a hollow slider for engaging and positioning a tube that slides therethrough; and a slide case within which the hollow slider travels to allow the tube to be aligned with a selected filter well of the plurality of filter wells, wherein when the tube is aligned with the selected filter well, the tube is pushed through the hollow slider and into the selected filter well to sealingly engage the selected filter well and to allow the tube to deposit a biological sample onto a filter in the bottom of the selected filter well. The biological sample collector may be portable.

Murphy, Gloria A. (French Camp, CA)

2010-09-07T23:59:59.000Z

217

Learning from Systems Biology  

Science Conference Proceedings (OSTI)

... at the molecular level to that at the living organism (e.g., genomics, proteomics, etc.) ... How do we organize atoms and build systematically structural units at...

218

Molecular Phylogeny Reconstruction  

E-Print Network (OSTI)

Molecular Phylogeny Reconstruction Sudhir Kumar, Arizona State University, Tempe, Arizona, USA Alan Filipski, Arizona State University, Tempe, Arizona, USA Molecular phylogenetics deals with the inference molecular data. By modelling patterns of molecular change in protein and deoxyribonucleic acid (DNA

Kumar, Sudhir

219

Computational Biology and High Performance Computing 2000  

SciTech Connect

The pace of extraordinary advances in molecular biology has accelerated in the past decade due in large part to discoveries coming from genome projects on human and model organisms. The advances in the genome project so far, happening well ahead of schedule and under budget, have exceeded any dreams by its protagonists, let alone formal expectations. Biologists expect the next phase of the genome project to be even more startling in terms of dramatic breakthroughs in our understanding of human biology, the biology of health and of disease. Only today can biologists begin to envision the necessary experimental, computational and theoretical steps necessary to exploit genome sequence information for its medical impact, its contribution to biotechnology and economic competitiveness, and its ultimate contribution to environmental quality. High performance computing has become one of the critical enabling technologies, which will help to translate this vision of future advances in biology into reality. Biologists are increasingly becoming aware of the potential of high performance computing. The goal of this tutorial is to introduce the exciting new developments in computational biology and genomics to the high performance computing community.

Simon, Horst D.; Zorn, Manfred D.; Spengler, Sylvia J.; Shoichet, Brian K.; Stewart, Craig; Dubchak, Inna L.; Arkin, Adam P.

2000-10-19T23:59:59.000Z

220

From Molecular Computing to Molecular Programming  

E-Print Network (OSTI)

From Molecular Computing to Molecular Programming Masami Hagiya Graduate School of Science of the Japanese Molecular Computer Project, and foresee the future of the #12;eld. In addition to describing the major achievements of the project, Suyama's Dynamic Programming Molecular Computer and Sakamoto

Hagiya, Masami

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Thornridge Biology Home Page  

NLE Websites -- All DOE Office Websites (Extended Search)

How Do We Inherit Our Biological Characteristics How Do We Inherit Our Biological Characteristics How Do We Inherit Our Biological Characteristics? Shelly Peretz Science Department Chairperson Thornridge High School Office Phone: 708-225-4585 speretz@interaccess.com You are visitor Photograph taken from Genetic Pathology Gallery: Cytogenetics, University of Washington Medical Center. Be sure to submit the online sign-off each day. Introduction Individuals, families, health care providers and policymakers face important health care decisions every day. Today, with the growing awareness of the role that genetics plays in our society, decision-making requires more information than ever before. This project uses principles of biology to examine human genetics disorders. Students work in small groups (2-3) on projects which give them the opportunity to understand human

222

Genomics and Systems Biology  

NLE Websites -- All DOE Office Websites (Extended Search)

Genomics and Systems Biology Genomics and Systems Biology Genomics and Systems Biology Los Alamos scientists perform research in functional genomics and structural genomics, and applications for such work cover diverse fields such as energy, agriculture, and environmental cleanup. Get Expertise Babetta Marrone Biofuels Program Manager Email Cheryl Kuske DOE BER Biological System Science Division Program Manager Email Chris Detter Emerging Threats Program Manager: Email Rebecca McDonald Bioscience Communications Email "We were asked to build a rocket ship," said developer Joel Berendzen, "but instead we built a 10,000 mph motorcycle." - Sequedex team LANL leads the world in computational finishing of microbial genomes Protein research Read caption + In 2013, Los Alamos scientist Richard Sayre and his team genetically

223

BNL Biology Department - Publications  

NLE Websites -- All DOE Office Websites (Extended Search)

2003 2002 2001 File Format .pdf 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 Biology Department 2012 Publications Agarwal R., Burley S.K., and Swaminathan S. Structural...

224

Earthworm Digging Biology  

NLE Websites -- All DOE Office Websites (Extended Search)

Earthworm Digging Biology Name: claire Location: NA Country: NA Date: NA Question: I live in Northeast PA,Monroe County.My husband and I were riding through a State park and saw...

225

Vibrations, Quanta and Biology  

E-Print Network (OSTI)

Quantum biology is an emerging field of research that concerns itself with the experimental and theoretical exploration of non-trivial quantum phenomena in biological systems. In this tutorial overview we aim to bring out fundamental assumptions and questions in the field, identify basic design principles and develop a key underlying theme -- the dynamics of quantum dynamical networks in the presence of an environment and the fruitful interplay that the two may enter. At the hand of three biological phenomena whose understanding is held to require quantum mechanical processes, namely excitation and charge transfer in photosynthetic complexes, magneto-reception in birds and the olfactory sense, we demonstrate that this underlying theme encompasses them all, thus suggesting its wider relevance as an archetypical framework for quantum biology.

S. F. Huelga; M. B. Plenio

2013-06-27T23:59:59.000Z

226

White Ash Biology  

NLE Websites -- All DOE Office Websites (Extended Search)

White Ash Biology Name: blondi Location: NA Country: NA Date: NA Question: 1. Is the white ash tree endangered or is it a protected variety? 2. How does the white ash tree...

227

Saltcedar: Biology and Management  

E-Print Network (OSTI)

Saltcedar is a small tree that causes major problems along rivers in the western half of Texas and throughout the U.S. Southwest. This publication explains its biology and ecological impacts, water use and control strategies.

Hart, Charles R.

2009-05-04T23:59:59.000Z

228

Biology as a career  

NLE Websites -- All DOE Office Websites (Extended Search)

Biology as a career Name: Heather Skeba Location: NA Country: NA Date: NA Question: When I get into the real world I was thinking of being a biologist. How much schooling do you...

229

Tree Frog Biology  

NLE Websites -- All DOE Office Websites (Extended Search)

Tree Frog Biology Name: toreyi Location: NA Country: NA Date: NA Question: My mom transplanted a house cactus and found a frog buried in the soil. We do not want to throw it...

230

Bird Feet Biology  

NLE Websites -- All DOE Office Websites (Extended Search)

Bird Feet Biology Name: Jeanne Location: NA Country: NA Date: NA Question: Why don't birds feet freeze during the cold winter months? Replies: I'm not sure about all birds, but...

231

Mourning Dove Biology  

NLE Websites -- All DOE Office Websites (Extended Search)

Mourning Dove Biology Name: Bettina Location: NA Country: NA Date: NA Question: I have found a bird egg. I'm pretty sure it's a morning dove egg. I would like to know how to...

232

Molecular Biology of the Cell Vol. 15, 56595669, December 2004  

E-Print Network (OSTI)

, ordered here by increasing reactivity (reviewed in Shackelford et al., 2000). Oxidative stress in yeast be further oxi- dized to give HP (Monks et al., 1992; Shackelford et al., 2000). It has been previously

Botstein, David

233

Molecular Biology of the Cell Vol. 10, 649664, March 1999  

E-Print Network (OSTI)

how nuclear pores accomplish the complicated task of selective, bidirec- tional trafficking. Initial Role in Multiple Types of Nuclear Export Katharine S. Ullman,* Sundeep Shah, Maureen A. Powers of nucleocytoplasmic transport takes place through the nuclear pore. Peripheral pore structures are presumably poised

Forbes, Douglass

234

BMC Molecular Biology BioMed Central Methodology article  

E-Print Network (OSTI)

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background: Helicases play essential roles in many cellular processes including replication, transcription and translation. Most helicases translocate along one strand of the duplex while displacing the complementary strand (of either DNA or RNA). Thus, helicases have directionality. They move along nucleic acids in either the 3' ? 5 ' or 5' ? 3 ' direction. The directionality of helicases with low activity or of those that cannot initiate duplex unwinding from a substrate that contains only one single-stranded overhang region is difficult to determine. Results: An improved assay to determine helicase directionality was developed that uses a substrate containing biotinylated oligonucleotides. As a proof of concept, it was shown that the substrates substantially improve helicase activity and directionality determination for several DNA helicases in comparison to more traditional substrates. In addition, a universal substrate that can be used to determine the directionality of both 3' ? 5 ' and 5' ? 3 ' helicases was developed. Conclusion: It is shown here that the use of a biotin-streptavidin complex as a helicase substrate improves helicase activity and the determination of helicase directionality. The method described

Jae-ho Shin; Zvi Kelman

2006-01-01T23:59:59.000Z

235

BMC Molecular Biology BioMed Central Methodology article  

E-Print Network (OSTI)

Reverse transcription-quantitative polymerase chain reaction: description of a RIN-based algorithm for accurate data normalization

Re Ho-pun-cheung; Caroline Bascoul-mollevi; Eric Assenat; Florence Boissire-michot; Dominic Cellier; Marc Ychou; Evelyne Lopez-crapez

2009-01-01T23:59:59.000Z

236

Biochemistry Insect Biochemistry and Molecular Biology 35 (2005) 105115  

E-Print Network (OSTI)

peptides in fat body tissue. Here, we have expressed one of these peptides, Attacin (GmAttA1) in Drosophila products in the midgut, to render flies refractory to parasite transmission (Rio et al., 2004). Successful

Aksoy, Serap

237

Molecular Biology Of Early Olfactory Memory Regina M. Sullivan1  

E-Print Network (OSTI)

observed in the olfactory bulb (Brunjes, Haiqing Zhao and Randall R. Reed* Howard Hughes Medical Institute) and in tyrosine hydroxylase lev- els of periglomerular cells (Baker, 1990). The treatment also led to a thinner-Fos, in the bulb (Baker et al., 1999).cient neurons are slowly and specifically depleted The pruning of mitral cell

Sullivan, Regina M.

238

Molecular Biology of the Cell Vol. 11, 10111022, March 2000  

E-Print Network (OSTI)

and phosphorylation are dis- rupted in another maternal-effect mutant, nuclear-fallout. It is possible that nuclear-fallout (Sullivan et al., 1990, 1993; Postner et al., 1992). nuclear-fallout has recently been cloned; it encodes

Sullivan, William T.

239

Computing at Different Levels of Approximation: Examples in Molecular Biology  

Science Conference Proceedings (OSTI)

Lubrication is pervasive in both everyday and technical affairs. But understanding it at a fundamental level is in its infancy. The treatment of this kind of complex process is an area where CSE can shine. Computational science enables us to disentangle ...

Gnther H. Peters; T. Frimurer; S. Toxvaerd; O. h. Olsen; A. Svendsen

1995-09-01T23:59:59.000Z

240

Molecular Biology of the Cell Vol. 9, 24772490, September 1998  

E-Print Network (OSTI)

, adenovirus; Baf A1, bafilomycin A1; CMV, cytomeg- alovirus; DOX, doxycycline; HA, hemagglutinin; Ig

Apodaca, Gerard

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

UNIVERSITY OF CALIFORNIA, SANTA CRUZ MOLECULAR, CELL, AND DEVELOPMENTAL BIOLOGY  

E-Print Network (OSTI)

, and agarose gel electrophoresis; mouse colony management and genotyping; perform biochemical experiments procedures and in vivo virus work. Laboratory Organization/Maintenance: maintain lab equipment; keep records research laboratory. Good organizational, time management and problem solving skills. The abilities

California at Santa Cruz, University of

242

UNIVERSITY OF CALIFORNIA, SANTA CRUZ MOLECULAR, CELL AND DEVELOPMENTAL BIOLOGY  

E-Print Network (OSTI)

culture, and running experiments. In addition, lab organization duties include mouse colony management and maintenance of lab equipment and safety records. RANK: Junior Specialist I ­ II SALARY: $33,672 ­ $35 team, and demonstrate exceptional organizational, time management, and decision-making skills

California at Santa Cruz, University of

243

Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

Theory of Nanostructured Materials Theory of Nanostructured Materials The Theory of Nanostructured Materials Facility at the Molecular Foundry is focused on expanding our understanding of materials at the nanoscale. Our research connects the structural and dynamical properties of materials to their functions, such as electrical conductivity and storage, light-harvesting for electricity and fuel, or gas separation and sequestration. We develop and employ a broad range of tools, including advanced electronic-structure theory, excited-state methods, model Hamiltonians, and statistical mechanical models. This combination of approaches reveals how materials behave at the nanoscale, in pursuit of materials and devices that meet global energy and sustainability needs. Electronic structure of complex materials and interfaces for energy

244

Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

See the Foundry's full equipment list See the Foundry's full equipment list Nanofabrication Capabilities & Tools Major Capabilities: Instruments and Labs Zeiss Crossbeam 1540 EsB The Molecular Foundry Zeiss Cross-beam is one of the most versatile lithographic and inspection tools allowing fabrication of complex prototypes for nanoelectronics, nano-optical antenna, modifying scanning probe tips, rapid electrical contacting and many other applications. The 1500XB Cross Beam combines the Gemini field emission column (FESEM) with the Orsay Physics focused ion beam (FIB). In addition, the instrument offers a multi-channel gas injection system to allow ion and electron beam induced deposition (IBID and EBID) and chemically assisted ion beam etching (CAIBE). The tool can be used for lithographic patterning of materials or

245

Green Biologics | Open Energy Information  

Open Energy Info (EERE)

History Facebook icon Twitter icon Green Biologics Jump to: navigation, search Name Green Biologics Place Oxfordshire, United Kingdom Sector Biomass, Renewable Energy Product...

246

Biological & Environmental Research Abstracts Database  

Office of Scientific and Technical Information (OSTI)

Welcome to the Biological and Environmental Research Abstracts Database The U.S. Department of Energy's Office of Biological and Environmental Research (BER) conducts research in...

247

Structural Biology | Clean Energy | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

Structural Biology SHARE Structural Biology ORNL researcher Flora Meilleur prepares protein solutions for structural investigation with neutrons. Source: ORNL Flickr site...

248

SLAC National Accelerator Laboratory - Biology  

NLE Websites -- All DOE Office Websites (Extended Search)

Biology Image of the HIV Antibody moving towards a molecule Biological molecules are the machinery of life. Each year hundreds of scientists come to SLAC's Stanford Synchrotron...

249

Biology Department - Brookhaven National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

Links of Interest Wikipedia (STEM) M.E. Mller-Insitute for Structural Biology National Institute of Biomedical Micoscopy Sosiety of America New York Structural Biology Center...

250

Genomes, Phylogeny, and Evolutionary Systems Biology  

E-Print Network (OSTI)

tested by synthetic biology (de novo design of biologicalEVOLUTIONARY SYSTEMS BIOLOGY MNICA MEDINA *, Department of45639 characters Systems biology is in the eye of the

Medina, Monica

2005-01-01T23:59:59.000Z

251

Engineering optical traps for new environments and applications in the measurement of biological adhesives and motors  

E-Print Network (OSTI)

Optical traps have played a central role in the exploration of biological systems through the examination of molecular motors, biopolymers, and many other interactions at the nano and micro length scales. This thesis seeks ...

Appleyard, David Collins

2009-01-01T23:59:59.000Z

252

Report of The Structural Biology Subcommittee of The Biological and  

Office of Science (SC) Website

Report of The Structural Biology Subcommittee of The Report of The Structural Biology Subcommittee of The Biological and Environmental Research Advisory Committee Biological and Environmental Research Advisory Committee (BERAC) BERAC Home Meetings Members Charges/Reports Current BERAC Charges Archive of BERAC Reports Charter .pdf file (40KB) BER Committees of Visitors BER Home Charges/Reports Report of The Structural Biology Subcommittee of The Biological and Environmental Research Advisory Committee Print Text Size: A A A RSS Feeds FeedbackShare Page REPORT of the STRUCTURAL BIOLOGY SUBCOMMITTEE of the BIOLOGICAL AND ENVIRONMENTAL RESEARCH ADVISORY COMMITTEE In response to the charge letter of Dr. Martha Krebs, May 28, 1998 Executive Summary Structural biology and especially macromolecular crystallography are playing an increasingly important role in biological discoveries. In order

253

7th Annual Systems Biology Symposium: Systems Biology and Engineering  

DOE Green Energy (OSTI)

Systems biology recognizes the complex multi-scale organization of biological systems, from molecules to ecosystems. The International Symposium on Systems Biology has been hosted by the Institute for Systems Biology in Seattle, Washington, since 2002. The annual two-day event gathers the most influential researchers transforming biology into an integrative discipline investingating complex systems. Engineering and application of new technology is a central element of systems biology. Genome-scale, or very small-scale, biological questions drive the enigneering of new technologies, which enable new modes of experimentation and computational analysis, leading to new biological insights and questions. Concepts and analytical methods in engineering are now finding direct applications in biology. Therefore, the 2008 Symposium, funded in partnership with the Department of Energy, featured global leaders in "Systems Biology and Engineering."

Galitski, Timothy P.

2008-04-01T23:59:59.000Z

254

Biological effectiveness of neutrons: Research needs  

Science Conference Proceedings (OSTI)

The goal of this report was to provide a conceptual plan for a research program that would provide a basis for determining more precisely the biological effectiveness of neutron radiation with emphasis on endpoints relevant to the protection of human health. This report presents the findings of the experts for seven particular categories of scientific information on neutron biological effectiveness. Chapter 2 examines the radiobiological mechanisms underlying the assumptions used to estimate human risk from neutrons and other radiations. Chapter 3 discusses the qualitative and quantitative models used to organize and evaluate experimental observations and to provide extrapolations where direct observations cannot be made. Chapter 4 discusses the physical principles governing the interaction of radiation with biological systems and the importance of accurate dosimetry in evaluating radiation risk and reducing the uncertainty in the biological data. Chapter 5 deals with the chemical and molecular changes underlying cellular responses and the LET dependence of these changes. Chapter 6, in turn, discusses those cellular and genetic changes which lead to mutation or neoplastic transformation. Chapters 7 and 8 examine deterministic and stochastic effects, respectively, and the data required for the prediction of such effects at different organizational levels and for the extrapolation from experimental results in animals to risks for man. Gaps and uncertainties in this data are examined relative to data required for establishing radiation protection standards for neutrons and procedures for the effective and safe use of neutron and other high-LET radiation therapy.

Casarett, G.W.; Braby, L.A.; Broerse, J.J.; Elkind, M.M.; Goodhead, D.T.; Oleinick, N.L.

1994-02-01T23:59:59.000Z

255

Gordon Research Conference on Mammary Gland Biology  

SciTech Connect

The 1989 conference was the tenth in the series of biennial Gordon Research Conferences on Mammary Gland Biology. Traditionally this conference brings together scientists from diverse backgrounds and experience but with a common interest in the biology of the mammary gland. Investigators from agricultural and medical schools, biochemists, cell and molecular biologists, endocrinologists, immunologists, and representatives from the emerging biotechnology industries met to discuss current concepts and results on the function and regulation of the normal and neoplastic mammary gland in a variety of species. Of the participants, approximately three-fourths were engaged in studying the normal mammary gland function, whereas the other quarter were engaged in studying the neoplastic gland. The interactions between scientists, clinicians, veterinarians examining both normal and neoplastic cell function serves to foster the multi-disciplinary goals of the conference and has stimulated many cooperative projects among participants in previous years.

1989-01-01T23:59:59.000Z

256

Biocompatible Quantum Dots for Biological Applications  

Science Conference Proceedings (OSTI)

Semiconductor quantum dots are quickly becoming a critical diagnostic tool for discerning cellular function at the molecular level. Their high brightness, long-lasting, size-tunable, and narrow luminescence set them apart from conventional fluorescence dyes. Quantum dots are being developed for a variety of biologically oriented applications, including fluorescent assays for drug discovery, disease detection, single protein tracking, and intracellular reporting. This review introduces the science behind quantum dots and describes how they are made biologically compatible. Several applications are also included, illustrating strategies toward target specificity, and are followed by a discussion on the limitations of quantum dot approaches. The article is concluded with a look at the future direction of quantum dots.

Rosenthal, Sandra [ORNL; Chang, Jerry [Vanderbilt University; Kovtun, Oleg [Department of Chemistry, Vanderbilt University, 7300 Stevenson Ctr Ln, Nashville, TN 37235, USA.; McBride, James [Vanderbilt University; Tomlinson, Ian [Oak Ridge National Laboratory (ORNL)

2011-01-01T23:59:59.000Z

257

A MOLECULAR AND QUANTUM MECHANICAL STUDY OF INDOLE-3-ACETIC ACID  

E-Print Network (OSTI)

A MOLECULAR AND QUANTUM MECHANICAL STUDY OF INDOLE-3- ACETIC ACID Rudolf Kiralj (PQ) and Márcia M with simple molecular structure. All the attempts to quantify its structure-biological activity relationship were not much successful up to date, mostly due to missing knowledge about some intrinsic molecular

Ferreira, Márcia M. C.

258

Molecular Communication Using Brownian Motion Sachin Kadloor, Raviraj S. Adve, and Andrew W. Eckford  

E-Print Network (OSTI)

1 Molecular Communication Using Brownian Motion with Drift Sachin Kadloor, Raviraj S. Adve, and Andrew W. Eckford Abstract Inspired by biological communication systems, molecular communication has been, this paper consid- ers molecular communication [1], in which information is transmitted by an exchange

Adve, Raviraj

259

Report of the Structural Biology Subcommittee of the Biological and  

Office of Science (SC) Website

Report of the Structural Biology Subcommittee of the Report of the Structural Biology Subcommittee of the Biological and Environmental Research Advisory Committee Biological and Environmental Research Advisory Committee (BERAC) BERAC Home Meetings Members Charges/Reports Current BERAC Charges Archive of BERAC Reports Charter .pdf file (40KB) BER Committees of Visitors BER Home Charges/Reports Report of the Structural Biology Subcommittee of the Biological and Environmental Research Advisory Committee Print Text Size: A A A RSS Feeds FeedbackShare Page REPORT of the STRUCTURAL BIOLOGY SUBCOMMITTEE of the BIOLOGICAL AND ENVIRONMENTAL RESEARCH ADVISORY COMMITTEE In response to the charge letter of Dr. Martha Krebs, June 10, 1997 Executive Summary Six years have elapsed since the previous report of the Structural Biology Subcommittee. Dramatic progress and advances in the field over this period

260

Biological and Environmental Research  

E-Print Network (OSTI)

BESC and throughout the scientific community. The Climate Change Science Institute (CCSI) has had its 2010 #12;Oak Ridge National Laboratory (ORNL) conducts basic and applied research and development in the Biological and Environmental Sciences Directorate (BESD) at the Oak Ridge National Laboratory (ORNL) perform

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Construction Biological and Chemical  

E-Print Network (OSTI)

Sequoia Hall William R. Hewlett Teaching Center Herrin Hall Gilbert Biological Sciences Gates Computer Sciences Golf Clubhouse Observatory Lou Henry Hoover House Vaden Health Center Bing Nursery School Stanford RD COLERIDGE AV HANSEN W Y OXFORD AV GRANTAV CAMBRIDGE AV KELLOGG AV CASTILLEJA AV SHERIDAN AV M

Li, Fei-Fei

262

Construction Biological and Chemical  

E-Print Network (OSTI)

Varian Physics Sequoia Hall William R. Hewlett Teaching Center Herrin Hall Gilbert Biological Sciences Sciences Observatory Lou Henry Hoover House Vaden Health Center Bing Nursery School Stanford Community Twain East Larkin West Dining Admin. Branner Dining Dining Beefeaters Avanti Parking Struct. 7 William H

Gerdes, J. Christian

263

Chemical biology drug discovery  

E-Print Network (OSTI)

Keywords Chemical biology drug discovery high-throughput screening protein ligands proteases novel chemical and biochemical methods for the identification and optimization of protein ligands us of pro- tein ligands. Results of this research are translated into protein-specific, chemical probes

Schüler, Axel

264

The Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

PEOPLE JOB OPPORTUNITIES USER'S ASSOCIATION CONTACT US Foundry Intranet DOE Basic Energy Sciences User Facilities Molecular Foundry Seminar "Tuning Phonons in Molecular...

265

A Novel Knowledge-Driven Systems Biology Approach for Phenotype Prediction upon Genetic Intervention  

Science Conference Proceedings (OSTI)

Deciphering the biological networks underlying complex phenotypic traits, e.g., human disease is undoubtedly crucial to understand the underlying molecular mechanisms and to develop effective therapeutics. Due to the network complexity and the relatively ... Keywords: Dynamic Bayesian network, genetic network, phenotype prediction, genetic intervention, systems biology, breast cancer, cell proliferation.

Rui Chang; Robert Shoemaker; Wei Wang

2011-09-01T23:59:59.000Z

266

Complex biological and bio-inspired systems  

SciTech Connect

The understanding and characterization ofthe fundamental processes of the function of biological systems underpins many of the important challenges facing American society, from the pathology of infectious disease and the efficacy ofvaccines, to the development of materials that mimic biological functionality and deliver exceptional and novel structural and dynamic properties. These problems are fundamentally complex, involving many interacting components and poorly understood bio-chemical kinetics. We use the basic science of statistical physics, kinetic theory, cellular bio-chemistry, soft-matter physics, and information science to develop cell level models and explore the use ofbiomimetic materials. This project seeks to determine how cell level processes, such as response to mechanical stresses, chemical constituents and related gradients, and other cell signaling mechanisms, integrate and combine to create a functioning organism. The research focuses on the basic physical processes that take place at different levels ofthe biological organism: the basic role of molecular and chemical interactions are investigated, the dynamics of the DNA-molecule and its phylogenetic role are examined and the regulatory networks of complex biochemical processes are modeled. These efforts may lead to early warning algorithms ofpathogen outbreaks, new bio-sensors to detect hazards from pathomic viruses to chemical contaminants. Other potential applications include the development of efficient bio-fuel alternative-energy processes and the exploration ofnovel materials for energy usages. Finally, we use the notion of 'coarse-graining,' which is a method for averaging over less important degrees of freedom to develop computational models to predict cell function and systems-level response to disease, chemical stress, or biological pathomic agents. This project supports Energy Security, Threat Reduction, and the missions of the DOE Office of Science through its efforts to accurately model biological systems at the molecular and cellular level. The project's impact encompasses applications to biofuels, to novel sensors and to materials with broad use for energy or threat reduction. The broad, interdisciplinary approach of CNLS offers the unparalleled strength of combining science backgrounds and expertise -a unique and important asset in attacking the complex science of biological organisms. This approach also allows crossfertilization, with concepts and techniques transferring across field boundaries.

Ecke, Robert E [Los Alamos National Laboratory

2009-01-01T23:59:59.000Z

267

6th Annual Systems Biology Symposium: Systems Biology and the Environment  

SciTech Connect

Systems biology recognizes the complex multi-scale organization of biological systems, from molecules to ecosystems. The International Symposium on Systems Biology is an annual two-day event gathering the most influential researchers transforming biology into an integrative discipline investigating complex systems. In recognition of the fundamental similarity between the scientific problems addressed in environmental science and systems biology studies at the molecular, cellular, and organismal levels, the 2007 Symposium featured global leaders in Systems Biology and the Environment. The objective of the 2007 Systems Biology and the Environment International Symposium was to stimulate interdisciplinary thinking and research that spans systems biology and environmental science. This Symposium was well aligned with the DOEs Genomics:GTL program efforts to achieve scientific objectives for each of the three DOE missions: Develop biofuels as a major secure energy source for this century, Develop biological solutions for intractable environmental problems, and Understand biosystems climate impacts and assess sequestration strategies Our scientific program highlighted world-class research exemplifying these priorities. The Symposium featured 45 minute lectures from 12 researchers including: Penny/Sallie Chisholm of MIT gave the keynote address Tiny Cells, Global Impact: What Prochlorococcus Can Teach Us About Systems Biology, plus Jim Fredrickson of PNNL, Nitin Baliga of ISB, Steve Briggs of UCSD, David Cox of Perlegen Sciences, Antoine Danchin of Institut Pasteur, John Delaney of the U of Washington, John Groopman of Johns Hopkins, Ben Kerr of the U of Washington, Steve Koonin of BP, Elliott Meyerowitz of Caltech, and Ed Rubin of LBNL. The 2007 Symposium promoted DOEs three mission areas among scientists from multiple disciplines representing academia, non-profit research institutions, and the private sector. As in all previous Symposia, we had excellent attendance of participants representing 20-30 academic or research-oriented facilities along with 25-30 private corporations from 5-10 countries. To broaden the audience for the Symposium and ensure the continued accessibility of the presentations, we made the presentation videos available afterward on the ISBs website.

Galitski, Timothy, P.

2007-04-01T23:59:59.000Z

268

BIOLOGICAL IRRADIATION FACILITY  

DOE Patents (OSTI)

A facility for irradiating biological specimens with neutrons is described. It includes a reactor wherein the core is off center in a reflector. A high-exposure room is located outside the reactor on the side nearest the core while a low-exposure room is located on the opposite side. Means for converting thermal neutrons to fast neutrons are movably disposed between the reactor core and the high and low-exposure rooms. (AEC)

McCorkle, W.H.; Cern, H.S.

1962-04-24T23:59:59.000Z

269

Modeling formalisms in Systems Biology  

E-Print Network (OSTI)

Systems Biology has taken advantage of computational tools and high-throughput experimental data to model several biological processes. These include signaling, gene regulatory, and metabolic networks. However, most of ...

Machado, Daniel

270

Structural Biology Helps Drug Discovery  

NLE Websites -- All DOE Office Websites (Extended Search)

Structural Biology Helps Drug Discovery Structural Biology Helps Drug Discovery Print Thursday, 19 July 2012 11:21 Last year, drug discovery company Plexxikon made front-page news...

271

Fluctuating-friction molecular motors  

E-Print Network (OSTI)

Abstract. We show that the correlated stochastic fluctuation of the friction coefficient can give rise to long-range directional motion of a particle undergoing Brownian random walk in a constant periodic energy potential landscape. The occurrence of this motion requires the presence of two additional independent bodies interacting with the particle via friction and via the energy potential, respectively, which can move relative to each other. Such three-body system generalizes the classical Brownian ratchet mechanism, which requires only two interacting bodies. In particular, we describe a simple two-level model of fluctuating-friction molecular motor that can be solved analytically. In our previous work [M.K., L.M and D.P. 2000 J. Nonlinear Opt. Phys. Mater. 9 157] this model has been first applied to understanding the fundamental mechanism of the photoinduced reorientation of dye-doped liquid crystals. Applications of the same idea to other fields such as molecular biology and nanotechnology can however be envisioned. As an example, in this paper we work out a model of the actomyosin system based on the fluctuating-friction mechanism. PACS numbers: 05.40.+j, 42.70.Df, 87.10.+eFluctuating-friction molecular motors 2 1.

unknown authors

2001-01-01T23:59:59.000Z

272

Biological Applications of Synchrotron Radiation:  

NLE Websites -- All DOE Office Websites (Extended Search)

Biological Applications of Synchrotron Radiation: Biological Applications of Synchrotron Radiation: An Evaluation of the State of the Field in 2002 A BioSync Report. Issued by the Structural Biology Synchrotron users Organization, October, 2002. 2 Table of Contents: Introduction .................................................................................................... 3 Abbreviations .................................................................................................. 5 Executive Summary ......................................................................................... 6 General Concerns ............................................................................................ 9 Synchrotron operations and maintenance ............................................... 9 NSLS, CHESS and the geographical distribution of beam lines

273

Conservation Biology Navjot S. Sodhi  

E-Print Network (OSTI)

Conservation Biology for All EDITED BY: Navjot S. Sodhi Department of Biological Sciences, National­0­19­955424­9 (Pbk.) 3 5 7 9 10 8 6 4 2 Sodhi and Ehrlich: Conservation Biology for All. http Introduction Navjot S. Sodhi and Paul R. Ehrlich 1 Introduction Box 1: Human population and conservation (Paul

Miami, University of

274

AGRI-SCIENCE CHEMICAL BIOLOGY  

E-Print Network (OSTI)

AGRI-SCIENCE CHEMICAL BIOLOGY NETWORK Vehicle for translation: Pioneering a cross-academic, -industry and -government network Chemical Biology Community Agri- Sciences Community Industry Policy makers), with multidisciplinary approaches being the drivers enabling this. Chemical Biology through physical science innovation

275

Perspectives Computational Biology in Brazil  

E-Print Network (OSTI)

Perspectives Computational Biology in Brazil Goran Neshich Introduction At the request of the PLoS Computational Biology Editor-in- Chief, I agreed to write about computational biology in Brazil (see author of the field itself is short); b) the current state of the field in Brazil; c) the influence of computational

Neshich, Goran

276

Intelligent systems for the molecular biologist  

SciTech Connect

This tutorial was one of eight tutorials selected to be presented at the Third International Conference on Intelligent Systems for Molecular Biology which was held in the United Kingdom from July 16 to 19, 1995. In this paper, one objective is to identify properties of DNA sequences that determine their function, by computer-aided statistical analysis and to accurately predict its function, given a new sequence. A related problem is to predict protein structure and function from the sequence.

Brutlag, D.L.

1995-12-31T23:59:59.000Z

277

Indoor Thermal Comfort, an Evolutionary Biology Perspective  

E-Print Network (OSTI)

Comfort, an Evolutionary Biology Perspective John L. StoopsComfort, Evolutionary Biology, Thermo Regulation, ThermalFrom an evolutionary biology perspective, the physiological

Stoops, John L.

2006-01-01T23:59:59.000Z

278

Computational biology and high performance computing  

E-Print Network (OSTI)

Paper in Computational Biology The First Step Beyond theM . Glaeser, Mol. & Cell Biology, UCB and Life SciencesLBNL-44460 Computational Biology and High Performance

Shoichet, Brian

2011-01-01T23:59:59.000Z

279

Computational Biology & KBase | Clean Energy| ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

Computational Biology and KBase SHARE Computational Biology and KBase The ever-increasing scale and complexity of biological data require advanced computational tools and resources...

280

Biology Division progress report, October 1, 1993--September 30, 1995  

Science Conference Proceedings (OSTI)

This Progress Report summarizes the research endeavors of the Biology Division of the Oak Ridge National Laboratory during the period October 1, 1993, through September 30, 1995. The report is structured to provide descriptions of current activities and accomplishments in each of the Division`s major organizational units. Lists of information to convey the entire scope of the Division`s activities are compiled at the end of the report. Attention is focused on the following research activities: molecular, cellular, and cancer biology; mammalian genetics and development; genome mapping program; and educational activities.

NONE

1995-10-01T23:59:59.000Z

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

The Molecular Foundry - Our Staff  

NLE Websites -- All DOE Office Websites (Extended Search)

Nanostructures Ron Zuckermann, Biological Nanostructures Staff Scientists Caroline Ajo-Franklin, Biological Nanostructures Shaul Aloni, Inorganic NanostructuresImaging and...

282

Structural Biology | Biosciences Division  

NLE Websites -- All DOE Office Websites (Extended Search)

Membrane Protein Membrane Protein Expression System BIO Home Page About BIO News Releases Research Publications People Contact Us Organization Chart Site Index Inside BIO BIO Safety About Argonne Membrane Protein Engineering Membrane protein expression system The cell membrane serves as the interface between an organism and its environment, and internal membranes in eukaryotes separate functional compartments within cells. Proteins inserted in these membranes carry out many essential biological processes including uptake of nutrients, excretion of wastes, signal transduction, and response to external stimuli. In addition, membrane proteins are used in elaborate bioenergetic schemes to fuel all normal cellular activities in healthy organisms. In this post-genomic era, about 35% of the genes in any genome encode membrane proteins. The fraction of proteins associated with the membrane in eukaryotes may be even higher (up to 40%). Notably, membrane proteins constitute the majority of drug targets, thus knowledge of the structures of these proteins would contribute greatly to our understanding of biological processes. Unfortunately, structural information for membrane proteins is exceedingly scarce. It is notoriously difficult to purify quantities of native material that are sufficient for crystallization attempts. As a result, to date, the three-dimensional structures of ~60 unique transmembrane proteins are known in comparison to the structures of representatives of more than ~4000 soluble protein families.

283

Analyzing Data for Systems Biology: Working at the Intersection of Thermodynamics and Data Analytics  

Science Conference Proceedings (OSTI)

Many challenges in systems biology have to do with analyzing data within the framework of molecular phenomena and cellular pathways. How does this relate to thermodynamics that we know govern the behavior of molecules? Making progress in relating data analysis to thermodynamics is essential in systems biology if we are to build predictive models that enable the field of synthetic biology. This report discusses work at the crossroads of thermodynamics and data analysis, and demonstrates that statistical mechanical free energy is a multinomial log likelihood. Applications to systems biology are presented.

Cannon, William R.; Baxter, Douglas J.

2012-08-15T23:59:59.000Z

284

Bounding the electrostatic free energies associated with linear continuum models of molecular solvation  

Science Conference Proceedings (OSTI)

The importance of electrostatic interactions in molecular biology has driven extensive research toward the development of accurate and efficient theoretical and computational models. Linear continuum electrostatic theory has been surprisingly successful

Jaydeep P. Bardhan; Matthew G. Knepley; Mihai Anitescu

2009-01-01T23:59:59.000Z

285

Encoded hydrogel microparticles for high-throughput molecular diagnostics and personalized medicine  

E-Print Network (OSTI)

The ability to accurately detect and quantify biological molecules in complex mixtures is crucial in basic research as well as in clinical settings. Advancements in genetic analysis, molecular diagnostics, and patient-tailored ...

Chapin, Stephen Clifford

2012-01-01T23:59:59.000Z

286

Molecular Interactions of Plutonium(VI) with Synthetic Manganese-Substituted Goethite  

E-Print Network (OSTI)

spectra were collected at SSRL on beamline 11-2 using a 30%Radiation Lightsource (SSRL) on beamline 10-2 using a fullyBasic Energy Sciences. The SSRL Structural Molecular Biology

Hu, Yung-Jin

2011-01-01T23:59:59.000Z

287

Computational methods for molecular docking  

Science Conference Proceedings (OSTI)

This tutorial was one of eight tutorials selected to be presented at the Third International Conference on Intelligent Systems for Molecular Biology which was held in the United Kingdom from July 16 to 19, 1995. Recently, it has been demonstrated that the knowledge of the three-dimensional structure of the protein can be used to derive new protein ligands with improved binding properties. This tutorial focuses on the following questions: What is its binding affinity toward a particular receptor? What are putative conformations of a ligand at the binding site? What are the similarities of different ligands in terms of their recognition capabilities? Where and in which orientation will a ligand bind to the active site? How is a new putative protein ligand selected? An overview is presented of the algorithms which are presently used to handle and predict protein-ligand interactions and to dock small molecule ligands into proteins.

Klebe, G. [BASF AG, Ludwigshafen (Germany); Lengauer, T.

1995-12-31T23:59:59.000Z

288

REVIEW ARTICLE Molecular Anions  

E-Print Network (OSTI)

REVIEW ARTICLE Molecular Anions Jack Simons Chemistry Department, Henry Eyring Center ReceiVed: February 28, 2008 The experimental and theoretical study of molecular anions has undergone on the experimental front. Theoretical developments on the electronic structure and molecular dynamics fronts now

Simons, Jack

289

Handbook of Chemical and Biological Warfare Agent ...  

U.S. Energy Information Administration (EIA)

Free ebook Handbook of Chemical and Biological Warfare Agent Decontamination pdf download.Handbook of Chemical and Biological Warfare Agent ...

290

Environmental Biology | Biosciences Division  

NLE Websites -- All DOE Office Websites (Extended Search)

Sustainable Bioenergy Crop Production Research Sustainable Bioenergy Crop Production Research Facility BIO Home Page About BIO News Releases Research Publications People Contact Us Organization Chart Site Index Inside BIO BIO Safety About Argonne Sustainable Bioenergy Crop Production Research Facility R. Michael Miller, Argonne contact (rmmiller@anl.gov) The overall goal of our field research facility is to identify plant and microbial processes that will be key contributors to sustainable low-input (fertilizer) bioenergy feedstock production and, at the same time, will enhance the capture and storage of greenhouse gases by plants and soils (biological carbon sequestration). A unique feature of our native perennial bioenergy research facility is a gradient of biodiversity -- both within and between species diversity. Although a number of long-term ecological studies have demonstrated benefits to biomass production and carbon sequestration from increased species richness, none have investigated whether within-species diversity (i.e., genetic diversity) can contribute similar improvements.

291

Salient Biological Features, Systematics,  

NLE Websites -- All DOE Office Websites (Extended Search)

Salient Salient Biological Features, Systematics, and Genetic Variation of Populus Gancho T. Slavov and Peter Zhelev Abstract The genus Populus includes morphologically diverse species of decid- uous, relatively short-lived, and fast-growing trees. Most species have wide ranges of distribution but tend to occur primarily in riparian or mountainous habitats. Trees from this genus are typically dioecious, flower before leaf emer- gence, and produce large amounts of wind-dispersed pollen or seeds. Seedlings are drought- and shade-intolerant, and their establishment depends on distur- bance and high soil moisture. Asexual reproduction is common and occurs via root sprouting and/or rooting of shoots. Fossil records suggest that the genus appeared in the late Paleocene or early Eocene (i.e., 50-60 million years BP). According to one commonly used classification, the genus is comprised

292

BIOLOGICAL BLAST EFFECTS  

SciTech Connect

The scope and nature of several blast hazards are delineated. Tentative criteria are set forth for threshold damage to humans. These criteria are related 10 nuclear weapons in terms of ground ranges and areas involved for one MT and ten MT surface detonations. To allow appreciation of the relative importance of blast with other effects, appropriate values are noted for ionizing and thermal radiation. Four categories of blast hazards are defined, and the character of each is described. The occurrence of combined injuries from pressure, missiles, and displacement is discussed. Experiences in the Texas City disaster of 1947 are reviewed. Selected data relate environmental conditions to gross biologic damage from overpressures, missiles, and impact loading. 86 references. (C.H.)

White, C.S.

1959-09-01T23:59:59.000Z

293

Biological Sciences Curriculum Study  

Science Conference Proceedings (OSTI)

The product, which culminates a two-year curriculum development project is a 152-page curriculum module dealing with genes, environment, and human behavior for use in high school biology classrooms. BSCS began the Project in January 1997 with funding from the U.S. Department of Energy. Development work included the input of an external advisory committee, external reviewers, a panel of writers, and national field testing. BSCS printed 20,000 copies of the module. To date, over 11,000 teachers have requested and received copies of the module free of charge. The curriculum exposes students to methods used to study behavioral genetics and examines the impact if this research on society.

Biological Sciences Curriculum Study (BSCS)

1999-11-29T23:59:59.000Z

294

Environmental Biology | Clean Energy | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

communities and the processes by which they transform materials and energy. Much of the funding for these studies is provided by DOE's Office of Biological and Environmental...

295

Biology Department - Brookhaven National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

Biology Scientific Staff Mammalian Systems Krassimira Botcheva DNA damage responses; whole genome p53 & chromatin analysis Paul Freimuth Adenovirus attachment, Expression & folding...

296

Biology Department - Brookhaven National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

Outside User Facility at the Biology Department News Releases: Simultaneous Nanoscale Imaging of Surface and Bulk Atoms Details of Bacterial 'Injection' System Revealed Structures...

297

BNL Biology Department - Patents Issued  

NLE Websites -- All DOE Office Websites (Extended Search)

Biology Staff For information about patents consult the US Patent Office. For scientific background follow links to investigator's pages. Studier, F. W., Inventor. High Density...

298

Structural Biology | Clean Energy | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

SHARE Structural Biology ORNL researcher Flora Meilleur prepares protein solutions for structural investigation with neutrons. Source: ORNL Flickr site Researchers are leveraging...

299

Biology Department - Brookhaven National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

Biology Department Bus: (631) 344 3415 Building 463 Fax: (631) 344 6398 (Administration) Brookhaven Natl. Lab. Fax: (631) 344 3407 (Department) Upton NY 11973-5000 Email:...

300

Biology Department - Brookhaven National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

Van't Hof Brookhaven National Laboratory From: 1962-1999 Research Interests The cell biology and cytogenetics of higher plants; specifically the development of commercial fiber in...

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Biology Department - Brookhaven National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

microscope because of their low contrast. Electron microscopy became useful to biology over the last 40 years as methods were developed to add high-contrast heavy atoms...

302

Biology Department - Brookhaven National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

are: I) Methods in membrane-protein structure determination In a presentation to the Biology Working Group at the Workshop on Fourth Generation Light Sources held at Argonne...

303

Systems Biology | More Science | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

between cells. Computational Biology and KBase -Focuses on research and development of advanced computational tools and resources for processing, analyzing, visualizing, and...

304

Fluctuating-friction molecular motors  

E-Print Network (OSTI)

We show that the correlated stochastic fluctuation of the friction coefficient can give rise to long-range directional motion of a particle undergoing Brownian random walk in a constant periodic energy potential landscape. The occurrence of this motion requires the presence of two additional independent bodies interacting with the particle via friction and via the energy potential, respectively, which can move relative to each other. Such three-body system generalizes the classical Brownian ratchet mechanism, which requires only two interacting bodies. In particular, we describe a simple two-level model of fluctuating-friction molecular motor that can be solved analytically. In our previous work [M.K., L.M and D.P. 2000 J. Nonlinear Opt. Phys. Mater. vol. 9, 157] this model has been first applied to understanding the fundamental mechanism of the photoinduced reorientation of dye-doped liquid crystals. Applications of the same idea to other fields such as molecular biology and nanotechnology can however be envisioned. As an example, in this paper we work out a model of the actomyosin system based on the fluctuating-friction mechanism.

Lorenzo Marrucci; Domenico Paparo; Markus Kreuzer

2001-10-12T23:59:59.000Z

305

The Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

Inelastic X-ray Scattering of transition metal compounds" April 2, 2013 - Caroline Ajo-Franklin, on "Engineering Electronic Nanointerfaces Into Organisms Using Synthetic Biology "...

306

Structural Biology | Biosciences Division  

NLE Websites -- All DOE Office Websites (Extended Search)

Photosynthetic Photosynthetic Reaction Center BIO Home Page About BIO News Releases Research Publications People Contact Us Organization Chart Site Index Inside BIO BIO Safety About Argonne Membrane Protein Engineering Photosynthetic reaction center: A novel quantum electronic circuit element Living cells contain a large variety of biomolecular complexes which self-assemble, recognize and control each other. These nanoscale devices, referred to as bionanodevices, perform critical cell functions such as gene expression, energy conversion, motion, signaling and metabolism. Recent advances in nanotechnology have paved the way to new possibilities and challenges for integrating highly efficient bionanodevices, designed and perfected by Nature during billions of years of evolution, into useful electronic devices. The main scientific and technological challenge in achieving this goal is the successful linkage of the biological components with the conventional, inorganic components. We are developing, implementing, and characterizing a new photobioelectronic device which converts light energy (photons) into an electronic signal by using the photosynthetic reaction center of purple bacteria as the active photoelement

307

Computational biology: a programming perspective  

Science Conference Proceedings (OSTI)

Computation via biological devices has been the subject of close scrutiny since von Neumann's early work some 60 years ago. In spite of the many relevant works in this field, the notion of programming biological devices seems to be, at best, ill-defined. ...

Lars Hartmann; Neil D. Jones; Jakob Grue Simonsen; Sren Bjerregaard Vrist

2011-01-01T23:59:59.000Z

308

Molecular Dynamics Simulations on High-Performance Reconfigurable Computing Systems  

Science Conference Proceedings (OSTI)

The acceleration of molecular dynamics (MD) simulations using high-performance reconfigurable computing (HPRC) has been much studied. Given the intense competition from multicore and GPUs, there is now a question whether MD on HPRC can be competitive. ... Keywords: FPGA-based coprocessors, application acceleration, bioinformatics, biological sequence alignment, high performance reconfigurable computing

Matt Chiu; Martin C. Herbordt

2010-11-01T23:59:59.000Z

309

Loop Quantum Theory Applied to Biology and Nonlinear Whole Biology  

E-Print Network (OSTI)

The loop quantum theory, which constitutes a very small discontinuous space, as new method is applied to biology. The model of protein folding and lungs is proposed. In the model, some known results are used, and four approximate conclusions are obtained: their structures are quantized, their space regions are finite, various singularities correspond to folding and crossed points, and different types of catastrophe exist. Further, based on the inseparability and correlativity of the biological systems, the nonlinear whole biology is proposed, and four basic hypotheses are formed. It may unify reductionism and holism, structuralism and functionalism. Finally, the medical meaning of the theory is discussed briefly.

Yi-Fang Chang

2008-01-02T23:59:59.000Z

310

The Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

LBNL Masthead A-Z Index Berkeley Lab masthead Phone Book Jobs Search The Molecular Foundry Home DOE - Office of Science ABOUT US FACILITIESCAPABILITIES RESEARCH BECOMING A USER...

311

The Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

PEOPLE JOB OPPORTUNITIES USER'S ASSOCIATION CONTACT US Foundry Intranet DOE Basic Energy Sciences User Facilities Molecular Foundry Seminar "Atomic Structure and Applications...

312

The Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

PEOPLE JOB OPPORTUNITIES USER'S ASSOCIATION CONTACT US Foundry Intranet DOE Basic Energy Sciences User Facilities Molecular Foundry Seminar Mineralization at the Organic...

313

The Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

PEOPLE JOB OPPORTUNITIES USER'S ASSOCIATION CONTACT US Foundry Intranet DOE Basic Energy Sciences User Facilities Molecular Foundry Seminar "What Happens to Crystals When...

314

The Molecular Foundry  

NLE Websites -- All DOE Office Websites (Extended Search)

Brett Helms, Berkeley Lab Title: Building Our Understanding of Nanocrystal Surface Structure Using Heterometallic Molecular Beacons Location: 67-3111 Chemla room View the Foundry...

315

A Molecular Simulation Study  

Science Conference Proceedings (OSTI)

Presentation Title, Enhanced CO2 Adsorption in Ti-exchanged Zirconium Organic Frameworks A Molecular Simulation Study. Author(s), Ravichandar Babarao...

316

Turbulent molecular clouds  

E-Print Network (OSTI)

Stars form within molecular clouds but our understanding of this fundamental process remains hampered by the complexity of the physics that drives their evolution. We review our observational and theoretical knowledge of molecular clouds trying to confront the two approaches wherever possible. After a broad presentation of the cold interstellar medium and molecular clouds, we emphasize the dynamical processes with special focus to turbulence and its impact on cloud evolution. We then review our knowledge of the velocity, density and magnetic fields. We end by openings towards new chemistry models and the links between molecular cloud structure and star--formation rates.

Hennebelle, Patrick

2012-01-01T23:59:59.000Z

317

PNNL: Biological Sciences: Frontiers in Biological Sciences Seminar Series  

NLE Websites -- All DOE Office Websites (Extended Search)

Frontiers in Biological Sciences Frontiers in Biological Sciences The seminar series features nationally/internationally known researchers from industry, government, and academia discussing novel ideas and advancements related to biological sciences. The hour-long seminars will feature a 45-minute talk by the featured speaker followed by 15 minutes of discussion with the audience members. 2014 Tim Donohue Timothy J. Donohue, Ph.D. Timothy J. Donohue, Ph.D. Department of Bacteriology University of Wisconsin-Madison Director, Great Lakes Bioenergy Research Center Tuesday, January 14, 2014 EMSL Auditorium 11:00 a.m. Biological Insights and Products Gleaned from Mining Bacterial Genomes and Pathways Professor Donohue has been a member of the UW-Madison Bacteriology Department since 1986. His research program studies bacterial energy

318

William R. Wiley Environmental Molecular Sciences Laboratory (EMSL) | U.S.  

NLE Websites -- All DOE Office Websites (Extended Search)

William R. Wiley Environmental William R. Wiley Environmental Molecular Sciences Laboratory (EMSL) Biological and Environmental Research (BER) BER Home About Research Research Abstracts Searchable Archive of BER Highlights External link Biological Systems Science Division (BSSD) Climate and Environmental Sciences Division (CESD) ARM Climate Research Facility Atmospheric System Research (ASR) Program Data Management Earth System Modeling (ESM) Program William R. Wiley Environmental Molecular Sciences Laboratory (EMSL) Integrated Assessment of Global Climate Change Regional & Global Climate Modeling (RGCM) Program Subsurface Biogeochemical Research Terrestrial Carbon Sequestration External link Terrestrial Ecosystem Science Facilities Science Highlights Benefits of BER Funding Opportunities Biological & Environmental Research Advisory Committee (BERAC)

319

Biological Science | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Biological Science Biological Science Biological Science The protozoan Plasmodium falciparum gliding through a cell in the gut of a mosquito, its primary host. Although five different species of Plasmodium can cause malaria, Plasmodium falciparum causes the most severe disease. | Photo courtesy of Wikipedia Commons. Read more The protozoan Plasmodium falciparum gliding through a cell in the gut of a mosquito, its primary host. Although five different species of Plasmodium can cause malaria, Plasmodium falciparum causes the most severe disease. | Photo courtesy of Wikipedia Commons. Read more Featured Your Density Isn't Your Destiny: The Future of Bad Cholesterol

320

Environmental Biology | Clean Energy | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

Environmental Biology Environmental Biology SHARE Environmental Biology David Graham, an ORNL microbial physiologist , examines thermokarst features outside Nome, Alaska, as part of the Next-Generation Ecosystem Experiment: Arctic project. Led by ORNL, this multidisciplinary, multi-institutional collaboration seeks to improve climate model predictions through advanced understanding of coupled processes in Arctic terrestrial ecosystems. [Image courtesy of Roy Kaltschmidt, Lawrence Berkeley National Laboratory] From gaining deeper insights into carbon cycling processes to understanding and predicting the mechanisms that control contaminant behavior in the environment, ORNL scientists are working to provide solutions for a cleaner world. This research cuts across numerous disciplines-including

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

VIEW FROM THE PENNINES: SYSTEMS BIOLOGY  

E-Print Network (OSTI)

A large number of trees were planted in the eld at the back of our garden about ten years ago. Some are relatively fast growing (silver birch, larch, some rs) and others less so (oak, horse chestnut). The planting was quite well thought out, and in the next few years the faster growing species will need to be thinned, creating space for the slowly maturing giants. This process has been something of a learning experience for me. I have been able to name most of the trees for years, but only now am I beginning to see how the trees grow (or do not grow) as a function of their variety and their position. It may already be too late for one young horse chestnut, which is having to compete for light and other resources with two well grown larches and a silver birch, but I am beginning to understand what needs to be done to encourage the more slowly growing varieties. The understanding and manipulation of the trees ' development requires the trees to be considered as a group, although information about individual trees (their growth rates for example) is important, and the e ect of thinning creates perturbations which take years to stabilize, so the whole process is slow and complicated. Choosing what to cut down is further in uenced by the steady state we may wish to create eventually, and the aesthetics of the interim states. The choices I am making in the eld are crude and uninformed, but the ecological system seems su ciently robust that my actions have not destroyed the overall feel of the eld. Much more subtle calculations are being made in biology, where, at least amongst some researchers, there is an awareness that considering anything in isolation, sequencing the human genome for example, does not necessarily help understand the actions or functions of the components. An approach to biology which brings together experimentation at the molecular level (chemistry), modelling (computer science and mathematics) and the investigation of how functionality is achieved (biology) has taken o in the last ve years. This approach is usually referred to as systems biology,

Paul Glendinning; Paul Glendinning

2005-01-01T23:59:59.000Z

322

Molecular models for explosives  

Science Conference Proceedings (OSTI)

Any fundamental understanding of detonations and explosives' behavior requires as a starting point a knowledge of molecular properties. Indeed, there is a sizable literature concerning observed decomposition kinetics, x-ray crystal structures, heats of formation, etc. for explosives. As a result of this extensive experimental work, a large and ever increasing number of observed properties of explosives are available. Given sufficient data, models for the prediction of molecular properties can be developed and calibrated. Nevertheless, many desirable molecular properties can be obtained with considerable effort and, in many cases, experimental measurements are not possible for practical reasons; e.g., bond dissociation energies are very difficult to obtain for explosives. Consequently, theoretical methods for obtaining these properties are quite desirable. In addition, it is oftentimes desired to estimate the properties of unknown molecules. Consequently, methods for the estimation of molecular properties, which might seem quite crude by other standards, can be of considerable practical value. We present in this paper some of our recent efforts at extending and developing molecular models for explosives. These efforts fall into three main areas: Estimation of crystal densities of organic nitrates and perchlorates by an entirely empirical group additivity method; calculation of molecular heats of formation and bond dissociation energies (BDE's) by a semi-empirical molecular orbital method (AM1); and the electronic structure of nitrobenzene as obtained from non-empirical (sometimes called ab initio molecular orbital calculations. 10 refs.

Ritchie, J.P.; Bachrach, S.M.

1987-01-01T23:59:59.000Z

323

Biology Department - Brookhaven National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

An Outside User Facility at the Biology Department An Outside User Facility at the Biology Department News Releases: Simultaneous Nanoscale Imaging of Surface and Bulk Atoms Details of Bacterial 'Injection' System Revealed Structures of Important Plant Viruses Determined Contacts: Joseph S. Wall James F. Hainfeld Martha N. Simon Frank E. Kito Beth Yu Lin wall@bnl.gov hainfeld@bnl.gov msimon@bnl.gov fkito@bnl.gov bylin@bnl.gov tel: (631) 344-2912 tel: (631) 344-3367 tel: (631) 344-3372 tel: (631) 344-3372 tel: (631) 344-3372 BNL STEM Group (click to enlarge) Biology Department, Bldg 463 Brookhaven National Lab Upton, NY 11973-5000 fax: (631) 344-3407 DOE BER Logo Facility: STEM is a custom-built electron microscope optimized for imaging unstained biological molecules with minimal radiation damage. The group at Brookhaven operates

324

Biological Interfaces | Clean Energy | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

Biological Interfaces A scientist examines bacteria isolated from the rhizosphere of a poplar tree as part of research on plant-microbe interactions.Source: ORNL Flickr site ORNL...

325

BNL Biology Department - Open House  

NLE Websites -- All DOE Office Websites (Extended Search)

Open House Open House in Biology is an annual event as part of BNL's Summer Sunday Tours in July and August. Have a look at pictures from past years: Open House 2001 Open House...

326

Biology Department - Brookhaven National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

National Laboratory From: 1599- 61400 Past BNL Research Interests I am the biology beamline scientist at x-ray beamline X25 at the National Synchrotron Light Source and...

327

Biology Department - Brookhaven National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

to Other Imaging Techniques (See Wiki of underlined terms) Biological STEM: (BNL, Engel, Leapman, Ortega) emphasis on low-dose, dark field imaging of very thin specimens (2nm...

328

Biology Department - Brookhaven National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

dry on a grid. To obtain residue-free water, we start with distilled water from the Biology Bldg. and pass it through a Millipore Milli Q system to remove ions (18M...

329

Structural Biology Helps Drug Discovery  

NLE Websites -- All DOE Office Websites (Extended Search)

Structural Biology Helps Drug Discovery Print Last year, drug discovery company Plexxikon made front-page news with its highly successful anti-cancer drug, Zelboraf, a product that...

330

Engineering supported membranes for cell biology  

E-Print Network (OSTI)

membranes in structural biology. J Struct Biol 168:12 50.supported membranes for cell biology Cheng-han Yu Jay T.range problems in cell biology. Because lateral mobility of

Yu, Cheng-han; Groves, Jay T.

2010-01-01T23:59:59.000Z

331

The systems biology simulation core algorithm  

E-Print Network (OSTI)

Keller et al. : The systems biology simulation core algo-rithm. BMC Systems Biology 2013 7:55. Page 16 of 16 SubmitMacilwain C: Systems biology: evolving into the mainstream.

2013-01-01T23:59:59.000Z

332

Three Dimensional Molecular Imaging for Lignocellulosic Materials  

DOE Green Energy (OSTI)

components sequestered in the rigid cell walls of plants. A detailed chemical and structural understanding of this pre-enzymatic processing in space and time was the focus of this program. We worked to develop new imaging strategies that produce real-time molecular speciation information in situ; extract sub-surface information about the effects of processing; and follow the spatial and temporal characteristics of the molecular species in the matrix and correlate this complex profile with saccharification. Spatially correlated SIMS and Raman imaging were used to provide high quality, high resolution subcellular images of Miscanthus cross sections. Furthermore, the combination of information from the mass spectrometry and Raman scattering allows specific chemical assignments of observed structures, difficult to assign from either imaging approach alone and lays the foundation for subsequent heterocorrelated imaging experiments targeted at more challenging biological systems, such as the interacting plant-microbe systems relevant to the rhizosphere.

Bohn, Paul W.; Sweedler, Jonathan V.

2011-06-09T23:59:59.000Z

333

(Theory of relative biological effectiveness)  

SciTech Connect

Research continued on relative biological effectiveness, in the following areas: radial distribution of dose about the path of an energetic heavy ion; the response of E. Coli mutants to ionizing radiations; the application of a fragmentation model to to the calculation of cell survival and mutation with heavy ion beams; biological radiation effects from gamma radiation and heavy ion beams on organisms; cancer induction in the Harderian Gland by HZE particles; and effects of low dose radiations. (CBS)

Katz, R.

1992-06-15T23:59:59.000Z

334

Biological Sludge Reduction and Analysis  

Science Conference Proceedings (OSTI)

This document describes research sponsored by EPRI and Advanced Biological Services (ABS). A series of experiments focused on the reduction and analysis of biological sludge in pulp mill wastewater. The first experiment involved optimization of the milling process through the alteration of the grinding gap and the number of times sludge was passed through the colloid mill in order to affect fractionation, dispersion, and lysis. For the second experiment, tests were conducted to evaluate the effect of ble...

2001-11-07T23:59:59.000Z

335

Conservation Biology (Biology 45300) An Ecology Course for the Fall of 2007 with RF Rockwell  

E-Print Network (OSTI)

Conservation Biology (Biology 45300) An Ecology Course for the Fall of 2007 with RF Rockwell Biology 45300 - Conservation Biology This undergraduate course provides an introduction to conservation biology with an emphasis on the interplay of various fields of biology in the mamangement and conservation

Lombardi, John R.

336

JIBS | Joint Institute for Biological Sciences | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

Joint Institute for Biological Sciences SHARE Joint Institute for Biological Sciences The Joint Institute of ORNL and the University of Tennessee has a single mission: to enable...

337

Green Pacific Biologicals Inc | Open Energy Information  

Open Energy Info (EERE)

"Green Pacific Biologicals, Inc." Retrieved from "http:en.openei.orgwindex.php?titleGreenPacificBiologicalsInc&oldid346039" Categories: Clean Energy Organizations...

338

Division of Chemical & Biological Sciences | Ames Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

Division of Chemical & Biological Sciences Division of Chemical & Biological Sciences Image Welcome Research teams in this Division conduct fundamental and applied studies of how...

339

BNL Biology Department - BusinessOps  

NLE Websites -- All DOE Office Websites (Extended Search)

Biology Department Mission Statement The mission of the Biology Department is to produce excellent science and advanced technology in a safe, environmentally benign manner, and to...

340

Computational biology and high performance computing  

E-Print Network (OSTI)

Biology and High Performance Computing Manfred Zorn, TeresaBiology and High Performance Computing Presenters: Manfred99-Portland High performance computing has become one of the

Shoichet, Brian

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

PNNL: Biological Sciences Programs & Projects: FCSD  

NLE Websites -- All DOE Office Websites (Extended Search)

Projects Biological & Environmental Research-PNNL Proteomics Center for Systems Biology of EnteroPathogens DOE Genomic Science Program Foundational Scientific Focus Area (FSFA)...

342

PNNL: About - Biological Sciences: Fundamental & Computational...  

NLE Websites -- All DOE Office Websites (Extended Search)

Scientists within the Biological Sciences Division perform systems and synthetic biology research and develop technologies focused on how cells, cell communities, and...

343

Experimental Data from the Proteomics Research Center for Integrative Biology  

DOE Data Explorer (OSTI)

The possible roles and importance of proteomics are rapidly growing across essentially all areas of biological research. The precise and comprehensive measurement of levels of expressed proteins and their modified forms can provide new insights into the molecular nature of cell-signaling pathways and networks, the cell cycle, cellular differentiation, and other processes relevant to understanding human health and the progression of various disease states. The ability to characterize protein complexes complements this capability, allowing hypotheses to be tested and the biological system operation to be defined. The Proteomics Research Center for Integrative Biology is a national user facility established and funded by the National Institute of General Medical Sciences component of the National Institutes of Health. This Center has been established to serve the biomedical research community by developing and integrating new proteomic technologies for collaborative and service studies, disseminating the new technologies, and training scientists in their use. The Center is housed in DOEs William R. Wiley Environmental Molecular Sciences Laboratory (EMSL) at the Pacific Northwest National Laboratory.

Smith, Richard D.

344

The war of the roses: demilitarizing invasion biology  

E-Print Network (OSTI)

Demilitarizing invasion biology BMH Larson new socialdemilitarizing invasion biology Brendon MH Larson Biologistsmetaphors within invasion biology. I argue that these

Larson, BMH

2005-01-01T23:59:59.000Z

345

Molecular Statics and Molecular Dynamics Simulations of the ...  

Science Conference Proceedings (OSTI)

Presentation Title, Molecular Statics and Molecular Dynamics Simulations of the Critical Stress for Motion of a/3 Screw Dislocations in a-Ti at Low...

346

Biology Direct BioMed Central Editorial Opening Pandora's Box: making biological discoveries through  

E-Print Network (OSTI)

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial Over two decades ago the first electronic databases which systematically collected protein and nucleic acid sequence and structure data came into existence. This period also saw the emergence of the first algorithms and their implementations to query these databases for sequence and structure similarities, to align sequences, and to identify of compositional features in sequences. A parallel advance was the integration of these disparate data collections into strongly interconnected databases, which included repositories of biomedical literature (e.g. Entrez). It would be no exaggeration to state that these computational developments played a role comparable to that of the polymerase chain reaction in the rise of modern molecular biology.

L Aravind

2007-01-01T23:59:59.000Z

347

Molecular structure, mechanical behavior and failure mechanism of the C-terminal cross-link domain in type I collagen  

E-Print Network (OSTI)

Collagen is a key constituent in structural materials found in biology, including bone, tendon, skin and blood vessels. Here we report a first molecular level model of an entire overlap region of a C-terminal cross-linked ...

Uzel, Sebastien Guy Marcel

348

A determination of air-sea gas exchange and upper ocean biological production from five noble gasses and tritiugenic helium-3  

E-Print Network (OSTI)

The five noble gases (helium, neon, argon, krypton, and xenon) are biologically and chemically inert, making them ideal oceanographic tracers. Additionally, the noble gases have a wide range of solubilities and molecular ...

Stanley, Rachel H. R

2007-01-01T23:59:59.000Z

349

A Molecular Dynamics  

Science Conference Proceedings (OSTI)

A Tale of Two States and More: Modeling of New Generation of Lattice Stability from Zero ... Analysis of Nano Fluid Using CFD-A Hybrid Approach for Cooling Purpose ... Molecular Dynamics Simulations of Grain Boundary Free Energy and

350

A Molecular Dynamic Study  

Science Conference Proceedings (OSTI)

A Tale of Two States and More: Modeling of New Generation of Lattice Stability from Zero ... Analysis of Nano Fluid Using CFD-A Hybrid Approach for Cooling Purpose ... Molecular Dynamics Simulations of Grain Boundary Free Energy and

351

An efficient biologically-inspired photocell enhanced by quantum coherence  

E-Print Network (OSTI)

Artificially reproducing the biological light reactions responsible for the remarkably efficient photon-to-charge conversion in photosynthetic complexes represents a new direction for the future development of photovoltaic devices. Here, we develop such a paradigm and present a model photocell based on the nanoscale architecture of photosynthetic reaction centres that explicitly harnesses the quantum mechanical effects recently discovered in photosynthetic complexes. Quantum interference of photon absorption/emission induced by the dipole-dipole interaction between molecular excited states guarantees an enhanced light-to-current conversion and power generation for a wide range of realistic parameters, opening a promising new route for designing artificial light-harvesting devices inspired by biological photosynthesis and quantum technologies.

Creatore, C; Emmott, S; Chin, A W

2013-01-01T23:59:59.000Z

352

An efficient biologically-inspired photocell enhanced by quantum coherence  

E-Print Network (OSTI)

Artificially reproducing the biological light reactions responsible for the remarkably efficient photon-to-charge conversion in photosynthetic complexes represents a new direction for the future development of photovoltaic devices. Here, we develop such a paradigm and present a model photocell based on the nanoscale architecture of photosynthetic reaction centres that explicitly harnesses the quantum mechanical effects recently discovered in photosynthetic complexes. Quantum interference of photon absorption/emission induced by the dipole-dipole interaction between molecular excited states guarantees an enhanced light-to-current conversion and power generation for a wide range of realistic parameters, opening a promising new route for designing artificial light-harvesting devices inspired by biological photosynthesis and quantum technologies.

C. Creatore; M. A. Parker; S. Emmott; A. W. Chin

2013-07-18T23:59:59.000Z

353

Model Energy Conversion Efficiency of Biological Systems  

Science Conference Proceedings (OSTI)

MML Researchers Model Energy Conversion Efficiency of Biological Systems. Novel, highly efficient energy conversion ...

2013-03-15T23:59:59.000Z

354

Technical Working Group on Biological Evidence Preservation  

Science Conference Proceedings (OSTI)

Technical Working Group on Biological Evidence Preservation. ... Sexual Assault Forensic Examiner Technical Assistance, National Protocol; ...

2013-06-28T23:59:59.000Z

355

Homeland Security Chemical/Biological/Radiological/Nuclear ...  

Science Conference Proceedings (OSTI)

... Information at NIST. Homeland Security Chemical/Biological/Radiological/ Nuclear/Explosives (CBRNE) Information at NIST. ...

2010-09-24T23:59:59.000Z

356

PNNL: Biological Sciences - Alphabetical List of all Biological...  

NLE Websites -- All DOE Office Websites (Extended Search)

Alphabetical List of all Biological Sciences Staff A B C D E F G H I J K L M N O P Q R S T U V W X Y Z A Adkins, Joshua N Anderson, Brian J Anderson, Gordon A Anderson, Lindsey N...

357

SC e-journals, Biology/Genetics  

Office of Scientific and Technical Information (OSTI)

Biology/Genetics Biology/Genetics ACM Transactions on Applied Perception (TAP) ACS Chemical Biology ACS Synthetic Biology Acta Biotheoretica Acta Neuropathologica Advances in Bioinformatics - OAJ Advances in Health Sciences Education Agriculture and Human Values Agroforestry Systems American Journal of Agricultural and Biological Science - OAJ American Journal of Medical Genetics Amino Acids Analyst Analytical and Bioanalytical Chemistry Analytical Biochemistry Anatomical Record, The Anatomy and Embryology Angiogenesis Animal Biology Animal Cognition Annals of The ICRP Annual Review of Biochemistry Annual Review of Biomedical Engineering Annual Review of Biophysics Annual Review of Cell and Developmental Biology Annual Review of Entomology Annual Review of Genetics Annual Review of Genomics and Human Genetics

358

Molecular Programming Pseudo-code Representation to Molecular Electronics  

E-Print Network (OSTI)

This research paper is proposing the idea of pseudo code representation to molecular programming used in designing molecular electronics devices. Already the schematic representation of logical gates like AND, OR, NOT etc.from molecular diodes or resonant tunneling diode are available. This paper is setting a generic pseudo code model so that various logic gates can be formulated. These molecular diodes have designed from organic molecules or Bio-molecules. Our focus is on to give a scenario of molecular computation through molecular programming. We have restricted our study to molecular rectifying diode and logic device as AND gate from organic molecules only.

Pradhan, Manas Ranjan

2010-01-01T23:59:59.000Z

359

Division of Biological and Medical Research annual research summary, 1983  

SciTech Connect

This research summary contains brief descriptions of research in the following areas: (1) mechanisms of hepatocarcinogenesis; (2) role of metals in cocarcinogenesis and the use of liposomes for metal mobilization; (3) control of mutagenesis and cell differentiation in cultured cells by tumor promoters; (4) radiation effects in mammalian cells; (5) radiation carcinogenesis and radioprotectors; (6) life shortening, tumor induction, and tissue dose for fission-neutron and gamma-ray irradiations; (7) mammalian genetics and biostatistics; (8) radiation toxicity studies; (9) hematopoiesis in chronic toxicity; (10) molecular biology studies; (11) chemical toxicology; (12) carcinogen identification and metabolism; (13) metal metabolism and toxicity; and (14) neurobehavioral chronobiology. (ACR)

Barr, S.H. (ed.)

1984-08-01T23:59:59.000Z

360

Statistical Inference for Big Data Problems in Molecular Biophysics  

SciTech Connect

We highlight the role of statistical inference techniques in providing biological insights from analyzing long time-scale molecular simulation data. Technologi- cal and algorithmic improvements in computation have brought molecular simu- lations to the forefront of techniques applied to investigating the basis of living systems. While these longer simulations, increasingly complex reaching petabyte scales presently, promise a detailed view into microscopic behavior, teasing out the important information has now become a true challenge on its own. Mining this data for important patterns is critical to automating therapeutic intervention discovery, improving protein design, and fundamentally understanding the mech- anistic basis of cellular homeostasis.

Ramanathan, Arvind [ORNL; Savol, Andrej [University of Pittsburgh School of Medicine, Pittsburgh PA; Burger, Virginia [University of Pittsburgh School of Medicine, Pittsburgh PA; Quinn, Shannon [University of Pittsburgh School of Medicine, Pittsburgh PA; Agarwal, Pratul K [ORNL; Chennubhotla, Chakra [University of Pittsburgh School of Medicine, Pittsburgh PA

2012-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Biological and Chemical Engineering Building,  

E-Print Network (OSTI)

Varian Physics Sequoia Hall William R. Hewlett Teaching Center Herrin Hall Gilbert Biological Sciences Blake Wilbur Clinic 777 OHNS Clinic Lou Henry Hoover House Vaden Health Center Bing Nursery School Admin. HFD Branner Dining Dining Parking Struct. 7 William H. Neukom Building Avery Plaza DAPER Corp

Sonnenburg, Justin L.

362

Theoretical Physics in Cellular Biology  

E-Print Network (OSTI)

Theoretical Physics in Cellular Biology: Some Illustrative Case Studies Living matter obeys the laws of physics, and the principles and methods of theoretical physics ought to find useful application observation, I will describe a few specific instances where approaches inspired by theoretical physics allow

363

Giant Molecular Magnetocapacitance  

Science Conference Proceedings (OSTI)

Capacitance of a nanoscale system is usually thought of having two contributions, a classical electrostatic contribution and a quantum contribution dependent on the density of states and/or molecular orbitals close to the Fermi energy. In this letter we demonstrate that in molecular nano-magnets and other magnetic nanoscale systems, the quantum part of the capacitance becomes spin-dependent, and is tunable by an external magnetic field. This molecular magnetocapacitance can be realized using single molecule nano-magnets and/or other nano-structures that have antiferromagnetic ground states. As a proof of principle, first-principles calculation of the nano-magnet [Mn3O(sao)3(O2CMe)(H2O)(py)3] shows that the charging energy of the high-spin state is 260 meV lower than that of the low-spin state, yielding a 6% difference in capacitance. A magnetic field of ~40T can switch the spin state, thus changing the molecular capacitance. A smaller switching field may be achieved using nanostructures with a larger moment. Molecular magnetocapacitance may lead to revolutionary device designs, e.g., by exploiting the Coulomb blockade magnetoresistance whereby a small change in capacitance can lead to a huge change in resistance.

Wu, Yuning [University of Florida, Gainesville; Zhang, Xiaoguang [ORNL; Cheng, Hai-Ping [University of Florida

2013-01-01T23:59:59.000Z

364

MDF | Manufacturing Demonstration Facility | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

BTRIC CNMS CSMB CFTF HFIR MDF Working with MDF NTRC OLCF SNS Titanium robotic hand holding sphere fabricated using additive manufacturing Home | User Facilities | MDF MDF |...

365

CFTF | Carbon Fiber Technology Facility | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

BTRIC CNMS CSMB CFTF Working with CFTF HFIR MDF NTRC OLCF SNS Carbon Fiber Technology Facility Home | User Facilities | CFTF CFTF | Carbon Fiber Technology Facility SHARE Oak...

366

Substructured multibody molecular dynamics.  

SciTech Connect

We have enhanced our parallel molecular dynamics (MD) simulation software LAMMPS (Large-scale Atomic/Molecular Massively Parallel Simulator, lammps.sandia.gov) to include many new features for accelerated simulation including articulated rigid body dynamics via coupling to the Rensselaer Polytechnic Institute code POEMS (Parallelizable Open-source Efficient Multibody Software). We use new features of the LAMMPS software package to investigate rhodopsin photoisomerization, and water model surface tension and capillary waves at the vapor-liquid interface. Finally, we motivate the recipes of MD for practitioners and researchers in numerical analysis and computational mechanics.

Grest, Gary Stephen; Stevens, Mark Jackson; Plimpton, Steven James; Woolf, Thomas B. (Johns Hopkins University, Baltimore, MD); Lehoucq, Richard B.; Crozier, Paul Stewart; Ismail, Ahmed E.; Mukherjee, Rudranarayan M. (Rensselaer Polytechnic Institute, Troy, NY); Draganescu, Andrei I.

2006-11-01T23:59:59.000Z

367

Chemical and Biological Engineering Department Code 1 Department of Chemical & Biological Engineering  

E-Print Network (OSTI)

Chemical and Biological Engineering Department Code 1 CODE of the Department of Chemical of Chemical & Biological Engineering. For clarity of presentation, some passages are copied directly from shall offer an undergraduate chemical and biological engineering program of technological, scientific

368

Biology  

Science Conference Proceedings (OSTI)

... PI NSF Materials Research Science and Engineering Program at the University of Pennsylvania, M. Klein, PI National Stable Isotope Resource at ...

369

A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm  

SciTech Connect

The 20th century was marked by extraordinary advances in our understanding of microbes and infectious disease, but pandemics remain, food and water borne illnesses are frequent, multi-drug resistant microbes are on the rise, and the needed drugs and vaccines have not been developed. The scientific approaches of the pastincluding the intense focus on individual genes and proteins typical of molecular biologyhave not been sufficient to address these challenges. The first decade of the 21st century has seen remarkable innovations in technology and computational methods. These new tools provide nearly comprehensive views of complex biological systems and can provide a correspondingly deeper understanding of pathogen-host interactions. To take full advantage of these innovations, the National Institute of Allergy and Infectious Diseases recently initiated the Systems Biology Program for Infectious Disease Research. As participants of the Systems Biology Program we think that the time is at hand to redefine the pathogen-host research paradigm.

Aderem, Alan; Adkins, Joshua N.; Ansong, Charles; Galagan, James; Kaiser, Shari; Korth, Marcus J.; Law, G. L.; McDermott, Jason E.; Proll, Sean; Rosenberger, Carrie; Schoolnik, Gary; Katze, Michael G.

2011-02-01T23:59:59.000Z

370

Molecular Mechanism Underlying Cellular Adaptive Response to Low Dose Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

Mechanism Underlying Cellular Adaptive Response to Low Dose Radiation Mechanism Underlying Cellular Adaptive Response to Low Dose Radiation Colette A. Sacksteder § , DJ Black ‡ , Heather Smallwood § , David G. Camp II † , and Thomas C. Squier § § Cell Biology and Biochemistry; † Biological Sciences Division Pacific Northwest National Laboratory, Richland WA 99352 ‡ School of Biological Sciences, University of Missouri, Kansas City MO 64110 The goal of this research is to identify the molecular mechanisms by which cells adapt to low dose radiation exposure. Previously we have shown a radiation dependent increase of Calmodulin (CaM) in RAW 264.7 macrophages (RAW). Therefore we hypothesize that CaM and associated signaling complexes are sensors of low-dose radiation, resulting in alterations in energy metabolism and gene expression. The ultimate experimental goal

371

Foundational platform for mammalian synthetic biology  

E-Print Network (OSTI)

The emergent field of synthetic biology is different from many other biological engineering efforts, in that its roots, design principles, and forward engineering perspective have been adopted from electrical engineering ...

Davidsohn, Noah (Noah Justin)

2013-01-01T23:59:59.000Z

372

Authentic teaching and learning through synthetic biology  

E-Print Network (OSTI)

Synthetic biology is an emerging engineering discipline that, if successful, will allow well-characterized biological components to be predictably and reliably built into robust organisms that achieve specific functions. ...

Kuldell, Natalie

373

Coexistence and efficiency of normal and anomalous transport by molecular motors in living cells  

E-Print Network (OSTI)

Recent experiments reveal both passive subdiffusion of various nanoparticles and anomalous active transport of such particles by molecular motors in the molecularly crowded environment of living biological cells. Passive and active microrheology reveals that the origin of this anomalous dynamics is due to the viscoelasticity of the intracellular fluid. How do molecular motors perform in such a highly viscous, dissipative environment? Can we explain the observed co-existence of the anomalous transport of relatively large particles of 100 to 500 nm in size by kinesin motors with the normal transport of smaller particles by the same molecular motors? What is the efficiency of molecular motors in the anomalous transport regime? Here we answer these seemingly conflicting questions and consistently explain experimental findings in a generalization of the well-known continuous diffusion model for molecular motors with two conformational states in which viscoelastic effects are included.

Igor Goychuk; Vasyl O. Kharchenko; R. Metzler

2013-09-26T23:59:59.000Z

374

Biology and medical research at the exascale.  

Science Conference Proceedings (OSTI)

Advances in computational hardware and algorithms that have transformed areas of physics and engineering have recently brought similar benefits to biology and biomedical research. Biological sciences are undergoing a revolution. High-performance computing has accelerated the transition from hypothesis-driven to design-driven research at all scales, and computational simulation of biological systems is now driving the direction of biological experimentation and the generation of insights.

Wolf, L.; Pieper, G. W. (CLS-CI); ( MCS)

2010-01-01T23:59:59.000Z

375

Accelerator Mass Spectrometry: Extreme Sensitivity in Biological ...  

THE LLNL TECHNOLOGY COMPANY PRODUCT 24 Partnering Today: Technology Transfer Highlights Accelerator Mass Spectrometry: Extreme Sensitivity in Biological Research

376

Handbook of Chemical and Biological Warfare Agent ...  

U.S. Energy Information Administration (EIA)

Description. Chemical and biological warfare agents are threats to the military and civilians alike in both terrorist and conventional warfare ...

377

Handbook of Chemical and Biological Warfare Agent ...  

U.S. Energy Information Administration (EIA)

Handbook of Chemical and Biological Warfare Agent Decontamination: George O. Bizzigolli, Richard P. Rhoads, Stephen J. Lee: 9781906799069: Books - ...

378

Transport of Molecular Motor Dimers in Burnt-Bridge Models  

E-Print Network (OSTI)

Dynamics of molecular motor dimers, consisting of rigidly bound particles that move along two parallel lattices and interact with underlying molecular tracks, is investigated theoretically by analyzing discrete-state stochastic continuous-time burnt-bridge models. In these models the motion of molecular motors is viewed as a random walk along the lattices with periodically distributed weak links (bridges). When the particle crosses the weak link it can be destroyed with a probability $p$, driving the molecular motor motion in one direction. Dynamic properties and effective generated forces of dimer molecular motors are calculated exactly as a function of a concentration of bridges $c$ and burning probability $p$ and compared with properties of the monomer motors. It is found that the ratio of the velocities of the dimer and the monomer can never exceed 2, while the dispersions of the dimer and the monomer are not very different. The relative effective generated force of the dimer (as compared to the monomer) also cannot be larger than 2 for most sets of parameters. However, a very large force can be produced by the dimer in the special case of $c=1/2$ for non-zero shift between the lattices. Our calculations do not show the significant increase in the force generated by collagenase motor proteins in real biological systems as predicted by previous computational studies. The observed behavior of dimer molecular motors is discussed by considering in detail the particle dynamics near burnt bridges.

Alexander Yu. Morozov; Anatoly B. Kolomeisky

2007-09-21T23:59:59.000Z

379

Los Alamos Lab: Los Alamos Molecular Recognition Alliance  

NLE Websites -- All DOE Office Websites (Extended Search)

Los Alamos Molecular Recognition Alliance: LAMRA Los Alamos Molecular Recognition Alliance: LAMRA Home About Us Partner Divisions Bioscience Division Chemistry Division International and Applied Technology Materials Physics Applications Division Theoretical Division Researchers Customize Affinity Reagents to Recognize Diseases and Biothreat Agents Novel affinity reagents are essential in the chemical and biological detection that is at the heart of the Los Alamos National Laboratory's mission in threat reduction, as well as being at the interface between many fundamental and applied Los Alamos research programs. Affinity reagent technologies at LANL are among the most advanced worldwide, with a wide range of different technologies focused on molecular recognition and the generation of affinity reagents both developed and under development. These include different affinity reagents (antibodies, fluorescent proteins, peptides, peptoids, carbohydrates, and oligonucleotides), and different selection and screening systems.

380

Molecular Pathogenesis of MALT lymphoma  

E-Print Network (OSTI)

underlying the pathogenesis of MALT lymphoma. 193 7.2.1 Aberrant molecular mechanisms of translocation positive MALT lymphoma..... 194 7.2.2 Aberrant molecular mechanism of translocation negative MALT...

Hamoudi, Rifat A

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Molecular Electroporation and the Transduction of Oligoarginines  

E-Print Network (OSTI)

Certain short polycations, such as TAT and polyarginine, rapidly pass through the plasma membranes of mammalian cells by an unknown mechanism called transduction as well as by endocytosis and macropinocytosis. These cell-penetrating peptides (CPPs) promise to be medically useful when fused to biologically active peptides. I offer a simple model in which one or more CPPs and the phosphatidylserines of the inner leaflet form a kind of capacitor with a voltage in excess of 180 mV, high enough to create a molecular electropore. The model is consistent with an empirical upper limit on the cargo peptide of 40--60 amino acids and with experimental data on how the transduction of a polyarginine-fluorophore into mouse C2C12 myoblasts depends on the number of arginines in the CPP and on the CPP concentration. The model makes three testable predictions.

Kevin Cahill

2008-10-14T23:59:59.000Z

382

Towards Molecular Programming Masami Hagiya  

E-Print Network (OSTI)

Towards Molecular Programming Masami Hagiya JST CREST and Department of Computer Science, Graduate research in the field of DNA and molecular computing by summarizing a recent international confer- ence and biotechnology, and the principles and methods for designing molecular systems with information

Hagiya, Masami

383

Molecular Implementation of Combinatory Computing  

E-Print Network (OSTI)

Molecular Implementation of Combinatory Computing for Nanostructure Synthesis and Control: Progress Molecular combinatory computing makes use of a small set of chemical re- actions that together have by several simulated nano-assembly applications, and discuss a possible molecular implementation in terms

MacLennan, Bruce

384

The molecular evolution of development  

E-Print Network (OSTI)

The molecular evolution of development Michael D. Purugganan Summary Morphological differences in understanding the genetic basis behind the evolution of developmental systems. Molecular evolutionary genetics-day attempts to study the evolution of development are centered at the molecular level and exploit

Purugganan, Michael D.

385

Molecular dynamics simulations and drug discovery  

E-Print Network (OSTI)

JE: On the determination of molecular fields. II. From thescalability for parallel molecular dynamics. J Comput PhysKale L, Schulten K: Scalable molecular dynamics with NAMD. J

Durrant, Jacob D; McCammon, J Andrew

2011-01-01T23:59:59.000Z

386

Molecular Gas in Early-type Galaxies  

E-Print Network (OSTI)

toward the center (first seen in the molecular gas in A+The EVLA . . . . . . . . . . . . . . . . 3.3 Molecular LineProfile . . . . . . . . . . . . . . 3.4 Molecular Gas

Alatalo, Katherine Anne

2012-01-01T23:59:59.000Z

387

PIA - Environmental Molecular Sciences Laboratory (EMSL) User...  

NLE Websites -- All DOE Office Websites (Extended Search)

Molecular Sciences Laboratory (EMSL) User System (ESU) PIA - Environmental Molecular Sciences Laboratory (EMSL) User System (ESU) PIA - Environmental Molecular Sciences Laboratory...

388

MSD Molecular Materials - Argonne National Laboratories, Materials...  

NLE Websites -- All DOE Office Websites (Extended Search)

Home Molecular Materials Molecular Materials Group carries out synthesis and characterization of novel materials whose unique properties originate at the molecular level. Our...

389

Molecular regulators of neurogenesis in Alzheimer's disease  

E-Print Network (OSTI)

and Pike, C. (1993). Molecular cascades in adaptive versusA. , and Saitoh, T. (1997). Molecular mechanisms of synapticBroeckhoven, C. (1998). Molecular genetics of Alzheimer's

Crews, Leslie Anne

2010-01-01T23:59:59.000Z

390

Molecular Biophysics Trainees are supported through the  

E-Print Network (OSTI)

Molecular Biophysics Trainees are supported through the College of Sciences at GeorgiaTech Research StudentsintheMolecularBiophysicstraining programmayconductthesisresearchwithany ofthefacultymemberslistedinthisbrochure. Studentsreceiveastipendsupplementfrom theprogram. InterestedingraduatestudyinMolecular Biophysics

Bennett, Gisele

391

Connecting the Molecular and the Continuum Scales  

NLE Websites -- All DOE Office Websites (Extended Search)

Connecting the Molecular and the Continuum Scales Connecting the Molecular and the Continuum Scales Key Challenges: A molecular-scale understanding of structure and surface...

392

Booly : a new data integration platform for systems biology  

E-Print Network (OSTI)

for enabling conceptual biology. Bioinformatics 2005, 21for data integration in biology. Trends Biotechnol 1999, 17(the unification of biology. The Gene Ontology Consortium.

Do, Long Hoang

2010-01-01T23:59:59.000Z

393

Importance of systems biology in engineering microbes for biofuel production  

E-Print Network (OSTI)

of knowledge from sys-tems biology approaches in metabolicand by the Synthetic Biology Engineering Research Center (Current Opinion in Chemical Biology 8. Blanch HW, Adams PD,

Mukhopadhyay, Aindrila

2011-01-01T23:59:59.000Z

394

Global warming and biological diversity  

SciTech Connect

This book is based on presentations given at the World Wildlife Fund's Conference on Consequences of the Greenhouse Effect for Biological Diverisity in 1988, and includes updated literature citations. The general topics covered in the book include the following: overview; summary of past responses of plants to climatic change; general ecological and physiological responses; ecosystems in 4 specific regions (arctic marine, Alaskan North Slope, NW US forests, and Mediterranean); global warming's implications for conservation. Ideas and data from many ecosystems and information about the relationships between biodiversity and climatic change are brought together with a balance of factual information and defensible scientific prognostication.

Peters, R.L.; Lovejoy, T.E. (eds.)

1992-01-01T23:59:59.000Z

395

Stem cell biology is population biology: differentiation of hematopoietic multipotent progenitors to common lymphoid and myeloid progenitors  

E-Print Network (OSTI)

M: Hematopoietic Stem Cell Biology. New York: Humana Press;In Hematopoietic Stem Cell Biology. Edited by Kondo M. Newmodels in stem cell biology: replacement, quiescence, and

Mangel, Marc; Bonsall, Michael B

2013-01-01T23:59:59.000Z

396

Rapid classification of biological components  

SciTech Connect

A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the invention, the analyte is a drug, such as marijuana, Cocaine (crystalline tropane alkaloid), methamphetamine, methyltestosterone, or mesterolone. The method involves attaching antigens of the surface of a solid support in a preselected pattern to form an array wherein the locations of the antigens are known; contacting the array with the biological sample such that a portion of antibodies in the sample reacts with and binds to antigens in the array, thereby forming immune complexes; washing away antibodies that do not form immune complexes; and detecting the immune complexes, thereby forming an antibody profile. Forensic samples are identified by comparing a sample from an unknown source with a sample from a known source. Further, an assay, such as a test for illegal drug use, can be coupled to a test for identity such that the results of the assay can be positively correlated to a subject's identity.

Thompson, Vicki S. (Idaho Falls, ID); Barrett, Karen B. (Meridian, ID); Key, Diane E. (Idaho Falls, ID)

2010-03-23T23:59:59.000Z

397

Three Dimensional Molecular Imaging for Lignocellulosic Materials  

SciTech Connect

The development of high efficiency, inexpensive processing protocols to render biomass components into fermentable substrates for the sequential processing of cell wall components into fuels and important feedstocks for the biorefinery of the future is a key goal of the national roadmap for renewable energy. Furthermore, the development of such protocols depends critically on detailed knowledge of the spatial and temporal infiltration of reagents designed to remove and separate the phenylpropenoid heteropolymer (lignin) from the processable sugar components sequestered in the rigid cell walls of plants. A detailed chemical and structural understanding of this pre-enzymatic processing in space and time was the focus of this program. We worked to develop new imaging strategies that produce real-time molecular speciation information in situ; extract sub-surface information about the effects of processing; and follow the spatial and temporal characteristics of the molecular species in the matrix and correlate this complex profile with saccharification. Spatially correlated SIMS and Raman imaging were used to provide high quality, high resolution subcellular images of Miscanthus cross sections. Furthermore, the combination of information from the mass spectrometry and Raman scattering allows specific chemical assignments of observed structures, difficult to assign from either imaging approach alone and lays the foundation for subsequent heterocorrelated imaging experiments targeted at more challenging biological systems, such as the interacting plant-microbe systems relevant to the rhizosphere.

Bohn, Paul W.; Sweedler, Jonathan V.

2011-06-09T23:59:59.000Z

398

Mesoscale Molecular Dynamics with LAMMPS  

Science Conference Proceedings (OSTI)

Tendency of Cooperative Grain Boundary Sliding in Nanocrystalline Materials Ultra-Large Scale Simulations of Deformation and Failure of Biological Protein...

399

Biological Water Gas Shift DOE Hydrogen, Fuel Cell, and Infrastructure  

E-Print Network (OSTI)

Conventional WGS Gasifier Reformer HTS LTS PSA H2 Biological WGS Gasifier Reformer Biological WGS H2 PSA Biological WGS (no Reformer) Steam/Power Biological WGS H2 Gasifier PSA #12;Technical Approach Key Challenges

400

Molecular conformations, interactions, and properties associated...  

NLE Websites -- All DOE Office Websites (Extended Search)

Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors Molecular conformations, interactions, and...

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Large Scale Computing and Storage Requirements for Biological...  

NLE Websites -- All DOE Office Websites (Extended Search)

of Energy's Office of Biological & Environmental Research and Advanced Scientific Computing Research (ASCR) to elucidate computing requirements for biological and...

402

LOS ALAMOS NATIONAL SECURITY, LLC BIOLOGICAL MATERIAL TRANSFER ...  

Folding Reporter Not 4 Profit BMTA LANL Agreement Number: LOS ALAMOS NATIONAL SECURITY, LLC . BIOLOGICAL MATERIAL TRANSFER AGREEMENT . THIS BIOLOGICAL ...

403

International Journal of Systems Biology  

NLE Websites -- All DOE Office Websites (Extended Search)

|| Bioinfo Publications || 57 || Bioinfo Publications || 57 International Journal of Systems Biology ISSN: 0975-2900 & E-ISSN: 0975-9204, Volume 4, Issue 1, 2013, pp.-57-72. Available online at http://www.bioinfopublication.org/jouarchive.php?opt=&jouid=BPJ0000252 IWATA M. 1 , SHIRAISHI F. 1 AND VOIT E.O. 2 * 1 Section of Bio-process design, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 6-10-1, Hakozaki, Higashi-Ku, Fukuoka 820-8581, Japan. 2 The Wallace H. Coulter, Department of Biomedical Engineering at Georgia Institute of Technology and Emory University, 313 Ferst Drive, Suite 4103, Atlanta, GA 30332-0535, U.S.A. *Corresponding Author: Email- eberhard.voit@bme.gatech.edu Received: August 05, 2013; Accepted: September 03, 2013

404

J. Math. Biol. (2010) 61:581616 DOI 10.1007/s00285-009-0309-0 Mathematical Biology  

E-Print Network (OSTI)

and convergence under the assumption that the rates of the reactions are monotone functions of the concentrations-mail: angeli@dsi.unifi.it D. Angeli Department of Electrical and Electronic Engineering, Imperial College and Sontag (2003), and, for obvious historical rea- sons, to a lesser extent in molecular and systems biology

Sontag, Eduardo

405

Functional quantum biology in photosynthesis and magnetoreception  

E-Print Network (OSTI)

Is there a functional role for quantum mechanics or coherent quantum effects in biological processes? While this question is as old as quantum theory, only recently have measurements on biological systems on ultra-fast time-scales shed light on a possible answer. In this review we give an overview of the two main candidates for biological systems which may harness such functional quantum effects: photosynthesis and magnetoreception. We discuss some of the latest evidence both for and against room temperature quantum coherence, and consider whether there is truly a functional role for coherence in these biological mechanisms. Finally, we give a brief overview of some more speculative examples of functional quantum biology including the sense of smell, long-range quantum tunneling in proteins, biological photoreceptors, and the flow of ions across a cell membrane.

Lambert, Neill; Cheng, Yuan-Chung; Li, Che-Ming; Chen, Guang-Yin; Nori, Franco

2012-01-01T23:59:59.000Z

406

Functional quantum biology in photosynthesis and magnetoreception  

E-Print Network (OSTI)

Is there a functional role for quantum mechanics or coherent quantum effects in biological processes? While this question is as old as quantum theory, only recently have measurements on biological systems on ultra-fast time-scales shed light on a possible answer. In this review we give an overview of the two main candidates for biological systems which may harness such functional quantum effects: photosynthesis and magnetoreception. We discuss some of the latest evidence both for and against room temperature quantum coherence, and consider whether there is truly a functional role for coherence in these biological mechanisms. Finally, we give a brief overview of some more speculative examples of functional quantum biology including the sense of smell, long-range quantum tunneling in proteins, biological photoreceptors, and the flow of ions across a cell membrane.

Neill Lambert; Yueh-Nan Chen; Yuan-Chung Cheng; Che-Ming Li; Guang-Yin Chen; Franco Nori

2012-05-04T23:59:59.000Z

407

Electrostatic thin film chemical and biological sensor  

DOE Patents (OSTI)

A chemical and biological agent sensor includes an electrostatic thin film supported by a substrate. The film includes an electrostatic charged surface to attract predetermined biological and chemical agents of interest. A charge collector associated with said electrostatic thin film collects charge associated with surface defects in the electrostatic film induced by the predetermined biological and chemical agents of interest. A preferred sensing system includes a charge based deep level transient spectroscopy system to read out charges from the film and match responses to data sets regarding the agents of interest. A method for sensing biological and chemical agents includes providing a thin sensing film having a predetermined electrostatic charge. The film is exposed to an environment suspected of containing the biological and chemical agents. Quantum surface effects on the film are measured. Biological and/or chemical agents can be detected, identified and quantified based on the measured quantum surface effects.

Prelas, Mark A. (Columbia, MO); Ghosh, Tushar K. (Columbia, MO); Tompson, Jr., Robert V. (Columbia, MO); Viswanath, Dabir (Columbia, MO); Loyalka, Sudarshan K. (Columbia, MO)

2010-01-19T23:59:59.000Z

408

On Biology as an Emergent Science  

E-Print Network (OSTI)

Biology is considered here as an "emergent science" in the sense of Anderson and of Laughlin and Pines. It is demonstrated that a straightforward mathematical definition of "biological system" is useful in showing how biology differs in structure from the lower levels in Anderson's "More is Different" hierarchy. Using cells in a chemostat as a paradigmatic exemplar of a biological system, it is found that a coherent collection of metabolic pathways through a single cell in the chemostat also satisfies the proposed definition of a biological system. This provides a theoretical and mathematical underpinning for Young's fundamental model of biological organization and integration. Evidence for the therapeutic efficacy of Young's method of analysis is provided by preliminary results of clinical trials of a specific application of Young's model to the treatment of cancer cachexia.

H. Pierre Noyes

2007-05-31T23:59:59.000Z

409

Cerenkov emission induced by external beam radiation stimulates molecular fluorescence  

SciTech Connect

Purpose: Cerenkov emission is induced when a charged particle moves faster than the speed of light in a given medium. Both x-ray photons and electrons produce optical Cerenkov photons in everyday radiation therapy of tissue; yet, this phenomenon has never been fully documented. This study quantifies the emissions and also demonstrates that the Cerenkov emission can excite a fluorophore, protoporphyrin IX (PpIX), embedded in biological phantoms. Methods: In this study, Cerenkov emission induced by radiation from a clinical linear accelerator is investigated. Biological mimicking phantoms were irradiated with x-ray photons, with energies of 6 or 18 MV, or electrons at energies 6, 9, 12, 15, or 18 MeV. The Cerenkov emission and the induced molecular fluorescence were detected by a camera or a spectrometer equipped with a fiber optic cable. Results: It is shown that both x-ray photons and electrons, at MeV energies, produce optical Cerenkov photons in tissue mimicking media. Furthermore, we demonstrate that the Cerenkov emission can excite a fluorophore, protoporphyrin IX (PpIX), embedded in biological phantoms. Conclusions: The results here indicate that molecular fluorescence monitoring during external beam radiotherapy is possible.

Axelsson, Johan; Davis, Scott C.; Gladstone, David J.; Pogue, Brian W. [Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755 (United States); Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03766 (United States); Thayer School of Engineering and Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire 03755 (United States)

2011-07-15T23:59:59.000Z

410

A Parallel Global Optimization Method for Solving Molecular Cluster and Polymer Conformation Problems  

E-Print Network (OSTI)

Identifying the conformations that a molecular cluster or polymer assumes in nature is an important problem with many practical applications in biology and medicine. It is believed that the naturally occurring molecular conformations minimize or nearly minimize the potential energy of the molecular cluster or polymer. The problem of finding the molecular configuration(s) with the lowest potential energy is a challenging global optimization problem with a potentially huge number of local solutions over a very large parameter space. We have developed a method to solve these types of problems, and have experimented with both molecular cluster and polymer applications, with very promising results. We have implemented the method on powerful massively parallel computers because of the enormous computational requirements of solving these types of problems. The parallel algorithms are interesting asynchronous, multi-level parallel algorithms. 1 Introduction The general problem of finding the ...

Richard H. Byrd; Elizabeth Eskow; Andr van der Hoek; Robert B. Schnabel; Klaas P. B. Oldenkamp

1995-01-01T23:59:59.000Z

411

Transporting & Shipping Hazardous Materials at LBNL: Biological...  

NLE Websites -- All DOE Office Websites (Extended Search)

containment as needed to keep the primary containers upright. Remove gloves and wash hands after preparing biological materials for transport. Lab coat, clean gloves, and...

412

EMSL: Science: Biological Interactions and Dynamics  

NLE Websites -- All DOE Office Websites (Extended Search)

Biological Interactions and Dynamics Cryo-transmission electron microscope image of Shewanella oneidensis MR-1. Understanding and optimizing the response of organisms and...

413

Computational biology and high performance computing  

E-Print Network (OSTI)

Acknowledgements for Community White Paper in ComputationalComputational Biology white paper Is there strong objectionportions of community white paper on high end computing

Shoichet, Brian

2011-01-01T23:59:59.000Z

414

Decontamination of Biological Threats in Water Supplies  

Science Conference Proceedings (OSTI)

Decontamination of Biological Threats in Water Supplies. ... The availability of safe pure drinking water in the United States is taken for granted. ...

2012-10-01T23:59:59.000Z

415

Handbook of Chemical and Biological Warfare Agent ...  

U.S. Energy Information Administration (EIA)

Chemical and biological warfare agents are continuing threats to the military on the battlefield as well as to civilians in the form of terrorist ...

416

Bookonline - Handbook of Chemical and Biological Warfare ...  

U.S. Energy Information Administration (EIA)

Handbook of Chemical and Biological Warfare Agent Decontamination I found this book here - AZBookFinder.com It's a simple and faster way to find a ...

417

Handbook of chemical and biological warfare agent ...  

U.S. Energy Information Administration (EIA)

Get this from a library! Handbook of chemical and biological warfare agent decontamination. [George O Bizzigotti; et al] -- "A one-stop reference ...

418

Synthetic Cells Shed Biological Insights While Delivering ...  

Science Conference Proceedings (OSTI)

Synthetic Cells Shed Biological Insights While Delivering Battery Power. ... Image of two artificial cells that can act as a tiny battery. ...

2012-10-01T23:59:59.000Z

419

MATH 496: Computational Biology ? Algebraic Statistical ... - CECM  

E-Print Network (OSTI)

MATH 496: Computational Biology ? Algebraic Statistical Model. 4. Log-linear Algebraic statistical Model : Part A: Introduction. 1. Definition: Let A = ( ) be a...

420

Why sequence census of fungal biology?  

NLE Websites -- All DOE Office Websites (Extended Search)

sequence census of fungal biology? Despite the large number of sequenced fungal genomes, the current taxonomic sampling is limited to well-characterized lineages of the Kingdom and...

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

EMSL: Science: GC: Membrane Biology - Project Achievements  

NLE Websites -- All DOE Office Websites (Extended Search)

Project Achievements EMSL's Membrane Biology Scientific Grand Challenge researchers grew Cyanothece in defined culture conditions and entrained it to a 12-hour light12-hour...

422

Computational Biology at Oak Ridge National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

Pipeline Domain Parser Prospect2 MIRA Welcome to Our Web Site We are the Computational Biology and Bioinformatics Group of the Biosciences Division of Oak Ridge National...

423

MODELING IN COMPUTATIONAL BIOLOGY NOTES OF ... - CECM  

E-Print Network (OSTI)

MODELING IN COMPUTATIONAL BIOLOGY. NOTES OF WEEK 9. 1. Fully Observed Markov Model: F. Sometimes we want to model a process of generating...

424

Biological Systems for Hydrogen Photoproduction (Presentation)  

DOE Green Energy (OSTI)

Presentation on Biological Systems for Hydrogen Photoproduction for the 2005 Hydrogen, Fuel Cells & Infrastructure Technologies Program Annual Review held in Arlington, Virginia, May 23-26, 2005.

Ghirardi, M. L.; Kim, K.; King, P.; Maness, P. C.; Seibert, M.

2005-05-01T23:59:59.000Z

425

Biological Nitrification Inhibition (BNI) Potential in Sorghum  

E-Print Network (OSTI)

for biological nitrification inhibition by sorghum (Sorghum bicolor). New Phytol 2008;180:442-451.in the root-DCM wash (?g) Wild sorghums Fig. 3. Relationship

2009-01-01T23:59:59.000Z

426

Assessment of Molecular Modeling & Simulation  

Science Conference Proceedings (OSTI)

This report reviews the development and applications of molecular and materials modeling in Europe and Japan in comparison to those in the United States. Topics covered include computational quantum chemistry, molecular simulations by molecular dynamics and Monte Carlo methods, mesoscale modeling of material domains, molecular-structure/macroscale property correlations like QSARs and QSPRs, and related information technologies like informatics and special-purpose molecular-modeling computers. The panel's findings include the following: The United States leads this field in many scientific areas. However, Canada has particular strengths in DFT methods and homogeneous catalysis; Europe in heterogeneous catalysis, mesoscale, and materials modeling; and Japan in materials modeling and special-purpose computing. Major government-industry initiatives are underway in Europe and Japan, notably in multi-scale materials modeling and in development of chemistry-capable ab-initio molecular dynamics codes.

None

2002-01-03T23:59:59.000Z

427

From systems biology to photosynthesis and whole-plant modeling: a conceptual model for integrating multi-scale networks  

SciTech Connect

Network analysis is now a common statistical tool for molecular biologists. Network algorithms are readily used to model gene, protein and metabolic correlations providing insight into pathways driving biological phenomenon. One output from such an analysis is a candidate gene list that can be responsible, in part, for the biological process of interest. The question remains, however, as to whether molecular network analysis can be used to inform process models at higher levels of biological organization. In our previous work, transcriptional networks derived from three plant species were constructed, interrogated for orthology and then correlated to photosynthetic inhibition at elevated temperature. One unique aspect of that study was the link from co-expression networks to net photosynthesis. In this addendum, we propose a conceptual model where traditional network analysis can be linked to whole-plant models thereby informing predictions on key processes such as photosynthesis, nutrient uptake and assimilation, and C partitioning.

Weston, David [ORNL; Hanson, Paul J [ORNL; Norby, Richard J [ORNL; Tuskan, Gerald A [ORNL; Wullschleger, Stan D [ORNL

2012-01-01T23:59:59.000Z

428

Electron Trapping by Molecular Vibration  

NLE Websites -- All DOE Office Websites (Extended Search)

Electron Trapping by Molecular Vibration Print In photoelectron spectroscopy experiments performed at the ALS, a group of researchers has found that electronic transitions normally...

429

EMSL: Capabilities: Molecular Science Computing  

NLE Websites -- All DOE Office Websites (Extended Search)

Information Chinook Supercomputer MSC User Policies Molecular Science Software Suite Graphics and Visualization Lab MSC Information MSC Research Meet the MSC Staff Related EMSL...

430

LAMMPS Molecular Dynamics Simulator - TMS  

Science Conference Proceedings (OSTI)

Nov 8, 2007 ... LAMMPS stands for Large-scale Atomic/Molecular Massively Parallel Simulator. LAMMPS has potentials for soft materials (biomolecules,...

431

EMSL: Capabilities: Molecular Science Computing  

NLE Websites -- All DOE Office Websites (Extended Search)

understand complex chemical systems at the molecular level by coupling the power of advanced computational chemistry techniques with existing and rapidly evolving...

432

GAS PHASE MOLECULAR DYNAMICS  

SciTech Connect

The goal of this research is the understanding of elementary chemical and physical processes important in the combustion of fossil fuels. Interest centers on reactions involving short-lived chemical intermediates and their properties. High-resolution, high-sensitivity, laser absorption methods are augmented by high temperature flow-tube reaction kinetics studies with mass-spectrometric sampling. These experiments provide information on the energy levels, structures and reactivity of molecular free radical species and, in turn, provide new tools for the study of energy flow and chemical bond cleavage in the radicals in chemical systems. The experimental work is supported by theoretical and computational work using time-dependent quantum wavepacket calculations that provide insights into energy flow between the vibrational modes of the molecule. The work of group members Fockenberg and Muckerman is described in separate abstracts of this volume.

SEARS,T.J.; HALL,G.E.; PRESES,J.M.; WESTON,R.E.,JR.

1999-06-09T23:59:59.000Z

433

Gas Phase Molecular Dynamics  

Science Conference Proceedings (OSTI)

The goal of this research is the understanding of elementary chemical and physical processes important in the combustion of fossil fuels. Interest centers on reactions involving short-lived chemical intermediates and their properties. High-resolution high-sensitivity laser absorption methods are augmented by high temperature flow-tube reaction kinetics studies with mass spectrometric sampling. These experiments provide information on the energy levels, structures and reactivity of molecular flee radical species and, in turn, provide new tools for the study of energy flow and chemical bond cleavage in the radicals in chemical systems. The experimental work is supported by theoretical and computational work using time-dependent quantum wavepacket calculations that provide insights into energy flow between the vibrational modes of the molecule.

Hall, G.E.; Prrese, J.M.; Sears, T.J.; Weston, R.E.

1999-05-21T23:59:59.000Z

434

Molecular beam kinetics  

SciTech Connect

The design of a crossed molecular beam ''supermachine'' for neutral-- neutral collisions is discussed. The universal electron bombardment ionizer, mass filter, and ion detection system of the detector, the supersonic nozzle sources, the differential pumping arrangement for the sources and detector, the time-of-flight detection of scattered products, and the overall configuration of the apparatus are described. The elastic scattering of two systems, CH$sub 4$ + Ar and NH$sub 3$ + Ar, has been measured using the supermachine with two supersonic nozzle sources. The rainbow structure and the interference oscillations are seen in each system. The best fit to the data was found using a Morse--Spline--Van der Waals (MSV) potential. The three potential parameters epsilon, r/sub m/, and $beta$ were found to be 2.20(+-0.04) x 10$sup -14$ ergs, 3.82(+-0.04)A, and 7.05 +- 0.20 for CH$sub 4$ + Ar, and 2.21(+-0.04) x 10$sup - 14$ ergs 3.93 (+-0.05)A, and 8.45 +- 0.30 for NH$sub 3$ + Ar. A new phenomenon in crossed molecular beams of condensation of a molecule on a cluster to form a complex was observed. A bromine molecule condensed on clusters of chlorine (Cl$sub 2$)/sub chi/ and ammonia (NH$sub 3$)/sub chi/. The value of chi for measurements in these experiments ranges from 7 to 40 for chlorine clusters and from 10 to 70 ammonia clusters. (auth)

Behrens, R. Jr.

1975-11-01T23:59:59.000Z

435

Biological conversion of synthesis gas  

DOE Green Energy (OSTI)

Mass transfer and kinetic studies were carried out for the Rhodospirillum rubrum and Chlorobium thiosulfatophilum bacterial systems. R. rubrum is a photosynthetic anaerobic bacterium which catalyzes the biological water gas shift reaction: CO + H[sub 2]0 [yields] CO[sub 2] + H[sub 2]. C. thiosulfatophilum is also a H[sub 2]S and COS to elemental sulfur. The growth of R. rubrum may be satisfactorily carried out at 25[degree] and 30[degree]C, while CO uptake and thus the conversion of CO best occurs at temperatures of either 30[degree], 32[degree] or 34[degree]C. The rate of conversion of COs and H[sub 2]O to CO[sub 2] and H[sub 2]S may be modeled by a first order rate expression. The rate constant at 30[degree]C was found to be 0.243 h[sup [minus]1]. The growth of C. thiosulfatophilum may be modeled in terms of incoming light intensity using a Monod equation: [mu] = [sub 351] + I[sub o]/[sup 0.152]I[sub o]. Comparisons of the growth of R. rubrum and C. thiosulfatophilum shows that the specific growth rate of C. thiosulfatophilum is much higher at a given light intensity.

Klasson, K.T.; Basu, R.; Johnson, E.R.; Clausen, E.C.; Gaddy, J.L.

1992-03-01T23:59:59.000Z

436

Division of Biological and Medical Research annual technical report, 1981  

Science Conference Proceedings (OSTI)

This report summarizes research during 1981 in the Division of Biological and Medical Research, Argonne National Laboratory. Studies in Low Level Radiation include comparison of lifetime effects in mice of low level neutron and gamma irradiation, delineation of the responses of dogs to continuous low level gamma irradiation, elucidation of mechanisms of radiation damage and repair in mammalian cells, and study of the genetic effects of high LET radiations. Carcinogenesis research addresses mechanisms of tumor initiation and promotion in rat liver, chemical carcinogenesis in cultured mammalian cells, and molecular and genetic mechanisms of chemical and ultraviolet mutagenesis in bacteria. Research in Toxicology uses a variety of cellular, whole animal, and chronobiological end points, chemical separations, and statistical models to evaluate the hazards and mechanisms of actions of metals, coal gasification by products, and other energy-related pollutants. Human Protein Index studies develop two-dimensional electrophoresis systems for diagnosis and detection of cancer and other disease. Biophysics research includes fundamental structural and biophysical investigations of immunoglobulins and key biological molecules using NMR, crystallographic, and x-ray and neutron small-angle scattering techniques. The final sections cover support facilities, educational activities, seminars, staff talks, staff, and funding agencies.

Rosenthal, M.W. (ed.)

1982-06-01T23:59:59.000Z

437

Research in thermal biology: Burning questions for coldwater stream fishes  

SciTech Connect

With the increasing appreciation of global warming impacts on ecological systems in addition to the myriad of land management effects on water quality, the number of literature citations dealing with the effects of water temperature on freshwater fish has escalated in the past decade. Given the many biological scales at which water temperature effects have been studied and the growing need to integrate knowledge from multiple disciplines of thermal biology to fully protect beneficial uses, we held that a survey of the most promising recent developments and an expression of some of the remaining unanswered questions with significant management implications would best be approached collectively by a diverse research community. We have identified five specific topic areas of renewed research where new techniques and critical thought could benefit coldwater stream fishes (particularly salmonids): molecular, organism, population/species, community and ecosystem, and policy issues in water quality. Our hope is that information gained through examination of recent research fronts linking knowledge at various scales will prove useful in managing water quality at a basin level to protect fish populations and whole ecosystems. Standards of the past were based largely on incipient lethal and optimum growth rate temperatures for fish species, while future standards should consider all integrated thermal impacts to the organism and ecosystem.

McCullough, Dr. Dale [University of California, Berkeley; Bartholow, Dr. John [U.S. Department of Fish and Wildlife; Jager, Yetta [ORNL; al., et. [Various Institutes

2009-01-01T23:59:59.000Z

438

Graduate Program Guide PLANT BIOLOGY AND CONSERVATION  

E-Print Network (OSTI)

Graduate Program Guide PLANT BIOLOGY AND CONSERVATION Northwestern University and the Chicago Botanic Garden Last Updated August 30, 2013 #12;2 The Plant Biology and Conservation (PBC) Graduate and conservation. The PBC graduate program brings together basic and applied sciences faculty from NU and the CBG

Reber, Paul J.

439

Graduate Program Guide PLANT BIOLOGY AND CONSERVATION  

E-Print Network (OSTI)

Graduate Program Guide PLANT BIOLOGY AND CONSERVATION Northwestern University and the Chicago Botanic Garden Last Updated April 24, 2013 #12;2 The Plant Biology and Conservation (PBC) Graduate Program and conservation. The PBC graduate program brings together basic and applied sciences faculty from NU and the CBG

Andrade, Jose

440

Graduate Program Guide PLANT BIOLOGY AND CONSERVATION  

E-Print Network (OSTI)

Graduate Program Guide PLANT BIOLOGY AND CONSERVATION Northwestern University and the Chicago Botanic Garden Last Updated March 19, 2013 #12;2 The Plant Biology and Conservation (PBC) Graduate Program and conservation. The PBC graduate program brings together basic and applied sciences faculty from NU and the CBG

Andrade, Jose

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Space directed coils for biological objectives  

Science Conference Proceedings (OSTI)

There are given different constructions of electromagnetic coils for using in biomedicine. There are developed constructions of space directed coils for increasing and decreasing the growth of cells in biology and medicine. Keywords: biological objectives, coils, decreasing, growth, increasing, space-directed

V. I. Vlastopulo

2010-07-01T23:59:59.000Z

442

Introduction to Biological Inspiration for Intelligent Systems  

Science Conference Proceedings (OSTI)

This paper serves as a short introduction for the special PerMIS session on Biological Inspiration (BI) for Intelligent Systems. The paper is organized into 4 parts. Part 1 provides a brief introduction to the idea and history of bio-inspiration for ... Keywords: biological inspiration, developmental robotics, dual cognitive systems, intelligent systems

Gary Berg-Cross

2008-08-01T23:59:59.000Z

443

Chemical Dynamics, Molecular Energetics, and Kinetics at the Synchrotron  

SciTech Connect

Scientists at the Chemical Dynamics Beamline of the Advanced Light Source in Berkeley are continuously reinventing synchrotron investigations of physical chemistry and chemical physics with vacuum ultraviolet light. One of the unique aspects of a synchrotron for chemical physics research is the widely tunable vacuum ultraviolet light that permits threshold ionization of large molecules with minimal fragmentation. This provides novel opportunities to assess molecular energetics and reaction mechanisms, even beyond simple gas phase molecules. In this perspective, significant new directions utilizing the capabilities at the Chemical Dynamics Beamline are presented, along with an outlook for future synchrotron and free electron laser science in chemical dynamics. Among the established and emerging fields of investigations are cluster and biological molecule spectroscopy and structure, combustion flame chemistry mechanisms, radical kinetics and product isomer dynamics, aerosol heterogeneous chemistry, planetary and interstellar chemistry, and secondary neutral ion-beam desorption imaging of biological matter and materials chemistry.

Leone, Stephen R.; Ahmed, Musahid; Wilson, Kevin R.

2010-03-14T23:59:59.000Z

444

Biology and Soft Matter | Neutron Sciences | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

Biology and Soft Matter Biology and Soft Matter SHARE Biology and Soft Matter This is a time of unprecedented opportunity for using neutrons in biological and soft matter research. The US Department of Energy (DOE) has invested in two forefront neutron user facilities, the accelerator-based Spallation Neutron Source (SNS) and the reactor-based High Flux Isotope Reactor (HFIR), at Oak Ridge National Laboratory (ORNL). Researchers have access to new instrumentation on some of the world's most intense neutron beam lines for studying the structure, function, and dynamics of complex systems. We anticipate that soft matter and biological sciences of tomorrow will require understanding, predicting, and manipulating complex systems to produce the new materials and products required to meet our nation's

445

Biological and Environmental Research Advisory Committee  

Office of Science (SC) Website

October 28-29, 2013 October 28-29, 2013 Biological and Environmental Research Advisory Committee (BERAC) BERAC Home Meetings BERAC Minutes BERAC Minutes Archive Members Charges/Reports Charter .pdf file (40KB) BER Committees of Visitors BER Home Meetings Biological and Environmental Research Advisory Committee October 28-29, 2013 Print Text Size: A A A RSS Feeds FeedbackShare Page Agenda .pdf file (10KB) Presentations: Sharlene Weatherwax .pdf file (575KB) - Office of Biological and Environmental Research Update Todd Anderson .pdf file (3.3MB) - Biological Systems Science Division Update Gary Geernaert .pdf file (2.2MB) - Climate and Environmental Sciences Division Update Minghua Zhang .pdf file (215KB) - Climate and Environmental Research Division COV Gary Stacey .pdf file (16.8MB) - Biological Nitrogen Fixation:

446

Fluctuations in molecular dynamics simulations  

Science Conference Proceedings (OSTI)

Statistical fluctuations of a system about its equilibrium state, monitored in a molecular dynamics simulation, are an effective means of computing the thermodynamic and kinetic properties of interfaces in metals and alloys. In this work, three applications ... Keywords: Fluctuations, Grain boundaries, Interfaces, Interfacial free energy, Mobility, Molecular dynamics

J. J. Hoyt; Z. T. Trautt; M. Upmanyu

2010-03-01T23:59:59.000Z

447

12th Biennial conference on Cellular and Molecular Biology of Soybeans  

SciTech Connect

The 2008 meeting attracted ~350 academic and industrial representatives and was the capstone of the DOE-led sequencing of the soybean genome (published 2010 in Nature). Many of the talks focused on engineering of soybean for biodiesel production and how to protect soybean yield. Several of the plenary talks were focused on the newly available genome sequence and how to effectively capitalize on this investment.

Jackson, Scott A.

2008-07-01T23:59:59.000Z

448

Molecular Biology of the Cell Vol. 3, 1199-1213, November 1992  

E-Print Network (OSTI)

of the glp-1 protein (10 epidermal growth factor [EGF]-like and 3 LNG repeats extracellularly and 6 cdcl, all four missense mutations in one phenotypic class map to the N-terminal EGF-like repeats and all six al., 1987). Based on these loss-of-func- tion defects, it has been proposed that wild-type glp-1

Maine, Eleanor

449

Study of Molecular and Biological Properties of Citrus exocortis viroid and Dweet mottle virus  

E-Print Network (OSTI)

oxygenase, endo-peptidase, helicase, and RNA-dependent RNAOxygenase protein; Hel: Helicase; RdRP: RNA-dependent RNAOxygenase protein; Hel: Helicase; RdRP: RNA-dependent RNA

Hajeri, Subhas

2010-01-01T23:59:59.000Z

450

Operations capability improvement of a molecular biology laboratory in a high throughput genome sequencing center  

E-Print Network (OSTI)

The Broad Institute is a research collaboration of MIT, Harvard University and affiliated hospitals, and the Whitehead Institute for Biomedical Research. Its scientific mission is to "(1) create tools for genomic medicine ...

Vokoun, Matthew R. (Matthew Richard)

2005-01-01T23:59:59.000Z

451

Molecular Imaging Approaches to Understanding the Roles of Hydrogen Peroxide Biology in Stress and Development  

E-Print Network (OSTI)

calculate required volumes of pOrn and Laminin workingovernight at 4 C. 3. Dilute pOrn in sterile water tog/mL working solution. 4. Add pOrn working solution to each

Dickinson, Bryan Craig

2010-01-01T23:59:59.000Z

452

Molecular Biology of the Cell Vol. 21, 186197, January 1, 2010  

E-Print Network (OSTI)

Data Envelopment Analysis Darold T. Barnum, University of Illinois at Chicago Sonali Tandon, Chicago. Sonali Tandon, Chicago Transit Authority is a Transit Research Analyst for the Chicago Transit Authority the Chicago Transit Authority. Tandon (2006) uses DEA to compare bus routes using data from a large American

Sheridan, Jennifer

453

Aufnahmeordnung fr den Masterstudiengang ,,Biochemistry and Molecular Biology" der Universitt Bremen  

E-Print Network (OSTI)

,5 (deutsches System) oder B (US-amerikanisches System) bewerteten ersten berufsqualifizierenden Hochschulab: Biochemie, Biologie oder Chemie oder angrenzenden Fachgebieten (wie Biotechnologie, Pharmazie, Medizin) oder, Biotechnologie, Chemie, Zellbiologie, Genetik, Mikrobiologie, Mathematik, Physik. c. Englisch

Bremen, Universität

454

Example 1 -LIFE SCIENCES/SCIENCES DE LA VIE Biology A Gene, Cell, Molecular  

E-Print Network (OSTI)

suspended in an aerosol gas. The aerosol is directed to a microwave plasma torch that generates plasma Sensing Films Duan, Yixiang (C-ACS) Pulsed, Atmospheric Pressure Plasma Source for Emission Dunbar, John M-Pressure Radio- frequency Nonthermal Plasma Discharge *Atmospheric Pressure Plasma Processing Reactor *Combined

Reid, Nancy

455

Multi-scale molecular simulations of biological systems: Parallelization of RAPTOR for Blue Gene/Q  

E-Print Network (OSTI)

/Q Adrian W. Lange MiraCon ALCF 03/06/13 #12;Multi-state empirical valence bond Goal: - To simulate (ALCF) - Each subcommunicator creates own instance of LAMMPS - Replica Exchange between subcomms LAMMPSC) Christopher Knight (ANL) Gard Nelson (UoC) Yuxing Peng (UoC) Jeff Hammond (ALCF) Luke Westby (Notre Dame

Kemner, Ken

456

Metabolomics of Complex Biological Systems to Uncover Molecular Mechanisms in Rice and Other Organisms  

E-Print Network (OSTI)

J-resolved H-1 NMR projections of biofluids for metabonomicsJ. ; Wold, S. Orthogonal projections to latent structures (J. ; Wold, S. Orthogonal projections to latent structures (

Barding, Gregory Alan

2013-01-01T23:59:59.000Z

457

WA_1995_012_ENGELHARDT_INSTITUTE_OF_MOLECULAR_BIOLOGY_Waiver...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

12ENGELHARDTINSTITUTEOFMOLECULARBIOLOGYWaiver.pdf WA1995012ENGELHARDTINSTITUTEOFMOLECULARBIOLOGYWaiver.pdf WA1995012ENGELHARDTINSTITUTEOFMOLECULARBIOLOGYWaive...

458

Molecular Biology of the Cell Vol. 20, 37833791, September 1, 2009  

E-Print Network (OSTI)

, Texas/Langham Creek 36 ZacharyErra-Hernandez SO FB 5-10 235 LasCruces,N.M./Onate 37 Philip Nicolaides JR 49 Dustin Schneider FR ILB 6-0 240 Hampton, N.J./North Hunterdon No. Name Cl. Pos. Ht. Wt. Hometown 35* Dylan Munoz ..........................................................Moon ­ ose 36 Zachary Erra-Hernandez

Roth, David B.

459

THEJOURNALOF BIOLOGICALCHEMISTRY (01991by The American Society for Biochemistry andMolecular Biology, Inc.  

E-Print Network (OSTI)

.Alton Jones Cell Science Center, Lake Placid, New York 12946 The role of the cytoplasmic loops and C by UnitedStatesPublicHealth Service Grants EY08061 (to K.P.), EY 06603 (to J. W. C.), and DK 38639 (to J. W-370 Wroclaw, Poland. 'The abbreviations usedare: Rho, rhodopsin; BTP, 1,3- his[tris(hydroxylmethyl)methylamine]propane

Palczewski, Krzysztof

460

Molecular simulation as a tool for studying lignin  

NLE Websites -- All DOE Office Websites (Extended Search)

Simulation Simulation as a Tool for Studying Lignin Amandeep K. Sangha, a,b Loukas Petridis, a,b Jeremy C. Smith, a,b,c Angela Ziebell, d,e and Jerry M. Parks a,b a UT/ORNL Center for Molecular Biophysics, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6309; parksjm@ornl.gov (for correspondence) b BioEnergy Science Center, Oak Ridge, TN c Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, M407 Walters Life Sciences, 1414 Cumberland Avenue, Knoxville, TN 37996 d National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO 80401-3393; angela.ziebell@nrel.gov (for correspondence) e BioEnergy Science Center, Golden, CO Published online 30 December 2011 in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ep.10628 Lignocellulosic biomass provides a sustainable source of sugars for biofuel and biomaterial production.

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Counting constituents in molecular complexes by fluorescence photon antibunching  

SciTech Connect

Modern single molecule fluorescence microscopy offers new, highly quantitative ways of studying the systems biology of cells while keeping the cells healthy and alive in their natural environment. In this context, a quantum optical technique, photon antibunching, has found a small niche in the continuously growing applications of single molecule techniques to small molecular complexes. Here, we review some of the most recent applications of photon antibunching in biophotonics, and we provide a guide for how to conduct photon antibunching experiments at the single molecule level by applying techniques borrowed from time-correlated single photon counting. We provide a number of new examples for applications of photon antibunching to the study of multichromophoric molecules and small molecular complexes.

Fore, S; Laurence, T; Hollars, C; Huser, T

2007-04-17T23:59:59.000Z

462

Molecular arrangement in water: random but not quite.  

DOE Green Energy (OSTI)

Water defines life on Earth from the cellular to the terrestrial level. Yet the molecular level arrangement in water is not well understood, posing problems in comprehending its very special chemical, physical and biological properties. Here we present high-resolution x-ray diffraction data for water clearly showing that its molecular arrangement exhibits specific correlations that are consistent with the presence of rings of H{sub 2}O molecules linked together by hydrogen bonds into tetrahedral-like units from a continuous network. This level of molecular arrangement complexity is beyond what a simple 'two-state' model of water (Bernal and Fowler 1933 J. Chem. Phys.1 515-48) could explain. It may not be explained by the recently put forward 'chains-clusters of completely uncorrelated molecules' model (Wernet et al 2004 Science 304 995-9) either. Rather it indicates that water is homogeneous down to the molecular level where different water molecules form tetrahedral units of different perfection and/or participate in rings of different sizes, thus experiencing different local environments. The local diversity of this tetrahedral network coupled to the flexibility of the hydrogen bonds that hold it together may explain well the rich phase diagram of water and why it responds non-uniformly to external stimuli such as, for example, temperature and pressure.

Petkov, V.; Ren, Y.; Suchomel, M. R. (X-Ray Science Division); (Central Michigan University)

2012-01-01T23:59:59.000Z

463

Borges Dilemma, Fundamental Laws, and Systems Biology  

E-Print Network (OSTI)

A well-known folk-law in biology is that there is no general law in biology because of exceptions. In her recent elegant essay E.F. Keller gave a particular nice presentation on the exceptions to rules or laws in biology [1]. Her example of scaling laws was especially illuminative. Nevertheless, for this cherished folk-law the present author is wondering about its exceptions, too. Several examples immediately jump into his minds. One, of course, would be the folk-law itself: It had no exception in biology. This would be a bit disappointing because it would only permit us to work as what the cartographers did in J.L. Borges fable [2]. Though eventually a map as big and as detail as the empire itself might be obtained, one would then ask where is the understanding within such an immense object? More disappointedly, such folk-law is really not biological. It has been used by some philosophers to argue against the unity of science [3]. Another example is distinctively biological and would be more exciting, and the author believes its existence should be not surprising to biologists: Evolution by Variation and Selection by Darwin and Wallace. To the authors knowledge this dynamical law has no exception in biology. Nevertheless, under the influence of above folk-law this marvelous dynamics has been named Darwins principle, just falling short to regard it as a fundamental law [4]. Any scientists and mathematicians would know better

Ping Ao

2008-01-01T23:59:59.000Z

464

SINGLE MOLECULE APPROACHES TO BIOLOGY, 2010 GORDON RESEARCH CONFERENCE, JUNE 27-JULY 2, 2010, ITALY  

SciTech Connect

The 2010 Gordon Conference on Single-Molecule Approaches to Biology focuses on cutting-edge research in single-molecule science. Tremendous technical developments have made it possible to detect, identify, track, and manipulate single biomolecules in an ambient environment or even in a live cell. Single-molecule approaches have changed the way many biological problems are addressed, and new knowledge derived from these approaches continues to emerge. The ability of single-molecule approaches to avoid ensemble averaging and to capture transient intermediates and heterogeneous behavior renders them particularly powerful in elucidating mechanisms of biomolecular machines: what they do, how they work individually, how they work together, and finally, how they work inside live cells. The burgeoning use of single-molecule methods to elucidate biological problems is a highly multidisciplinary pursuit, involving both force- and fluorescence-based methods, the most up-to-date advances in microscopy, innovative biological and chemical approaches, and nanotechnology tools. This conference seeks to bring together top experts in molecular and cell biology with innovators in the measurement and manipulation of single molecules, and will provide opportunities for junior scientists and graduate students to present their work in poster format and to exchange ideas with leaders in the field. A number of excellent poster presenters will be selected for short oral talks. Topics as diverse as single-molecule sequencing, DNA/RNA/protein interactions, folding machines, cellular biophysics, synthetic biology and bioengineering, force spectroscopy, new method developments, superresolution imaging in cells, and novel probes for single-molecule imaging will be on the program. Additionally, the collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings in the beauty of the Il Ciocco site in Tuscany, provides an avenue for scientists from different disciplines to interact and brainstorm and promotes cross-disciplinary collaborations directed toward compelling biological problems.

Professor William Moerner

2010-07-09T23:59:59.000Z

465

Introduction to Accelerated Molecular Dynamics  

SciTech Connect

Molecular Dynamics is the numerical solution of the equations of motion of a set of atoms, given an interatomic potential V and some boundary and initial conditions. Molecular Dynamics is the largest scale model that gives unbiased dynamics [x(t),p(t)] in full atomistic detail. Molecular Dynamics: is simple; is 'exact' for classical dynamics (with respect to a given V); can be used to compute any (atomistic) thermodynamical or dynamical properties; naturally handles complexity -- the system does the right thing at the right time. The physics derives only from the interatomic potential.

Perez, Danny [Los Alamos National Laboratory

2012-07-10T23:59:59.000Z

466

Introduction to Accelerated Molecular Dynamics  

SciTech Connect

Molecular Dynamics is the numerical solution of the equations of motion of a set of atoms, given an interatomic potential V and some boundary and initial conditions. Molecular Dynamics is the largest scale model that gives unbiased dynamics [x(t),p(t)] in full atomistic detail. Molecular Dynamics: is simple; is 'exact' for classical dynamics (with respect to a given V); can be used to compute any (atomistic) thermodynamical or dynamical properties; naturally handles complexity -- the system does the right thing at the right time. The physics derives only from the interatomic potential.

Perez, Danny [Los Alamos National Laboratory

2012-07-10T23:59:59.000Z

467

Molecular probe technology detects bacteria without culture  

E-Print Network (OSTI)

clinical samples, the molecular probes for L. brevis werepublished the design of our molecular probes (Figure 1a) and3, 1, a majority of the molecular probes for that genome

2012-01-01T23:59:59.000Z

468

Size adjustable separation of biologically active molecules  

E-Print Network (OSTI)

Separation of biologically active molecules (BAM's) is a problem for the pharmaceutical and biotechnology industries. Current technologies addressing this problem require too many techniques, toxic additives, and time to ...

Gutierrez, Mauricio R. (Mauricio Roberto)

2004-01-01T23:59:59.000Z

469

Biological applications of weal polyelectrolyte multilayers  

E-Print Network (OSTI)

This thesis research focused on biological applications of ultra-thin weak polyelectrolyte multilayers with specific emphasis on cell patterning, drug delivery, and antibacterial coatings. All of these very different ...

Berg, Michael C., Ph. D. Massachusetts Institute of Technology

2005-01-01T23:59:59.000Z

470

Southeastern Colorado Survey of Critical Biological Resources  

E-Print Network (OSTI)

biostimulation through adding manure was used to reclaim the oily sludge-contaminated soil. Materials and methods automated plate reader. All wells were blanked to the control well A1. For the BIOLOG data, average well

471

Green Pacific Biologicals - National Renewable Energy Laboratory  

p e G P B S t r a i n. Green Pacific Biologicals. Organism with high levels of oils Powerful genetic engineering. GPB [no Other companies. compromises] Secretion by ...

472

Complexity and Systems Biology of Microbial Biofuels  

E-Print Network (OSTI)

Complexity and Systems Biology of Microbial Biofuels 20-24 June 2011 (All and issues Theme: Biofuel systems and issues (Chair: Nigel Burroughs) 13 (Bielefeld) Biofuels from algae- challenges for industrial levels

Rand, David

473

Biological denitrification of high concentration nitrate waste  

DOE Patents (OSTI)

Biological denitrification of nitrate solutions at concentrations of greater than one kilogram nitrate per cubic meter is accomplished anaerobically in an upflow column having as a packing material a support for denitrifying bacteria.

Francis, Chester W. (Oak Ridge, TN); Brinkley, Frank S. (Knoxville, TN)

1977-01-01T23:59:59.000Z

474

PNNL: Biological Sciences Search for Staff: FCSD  

NLE Websites -- All DOE Office Websites (Extended Search)

Search for Staff Search for a Biological Sciences staff member (Last, First) Search Search for staff member by Group View Alphabetical List of all BSD Staff (may take a moment to...

475

What rough beast? Synthetic Biology and the Future of Biosecurity  

E-Print Network (OSTI)

Synthetic biology seeks to create modular biological parts that can be assembled into useful devices, allowing the modification of biological systems with greater reliability, at lower cost, with greater speed, and by a ...

Mohr, Scott C.

476

BIOLOGY & MEDICINE DIVISION ANNUAL REPORT 1978-1979  

E-Print Network (OSTI)

on research needs in actinide biology (CONF-770491, Seattle,J. Radiation Oncology Biology Physics 3: Lindgren, Frank T.Radiation Oncology Biology, Physics 3: 81-85 Magee, J.L and

Authors, Various

2010-01-01T23:59:59.000Z

477

Biology, History, Status and Conservation of Sacramento Perch, Archoplites interruptus  

E-Print Network (OSTI)

of freshwater fishery biology. Vol. II. Ames (IA): IowaWassmann Journal of Biology 24:141–160. Cook SJ, Philippmacrochirus. Invasion Biology 1:55-65. Mathews SB. 1962. The

Crain, Patrick K; Moyle, Peter B

2011-01-01T23:59:59.000Z

478

Biology of the Red Abalone, Haliotis rufescens, in Northern California  

E-Print Network (OSTI)

roles in conservation biology. Ecology 81:619-627. Caswell,Ontario. Environmental Biology of Fishes 64:281-292. Nash,eds. ) Abalone of the World: Biology Fisheries and Culture.

Leaf, Robert T.

2005-01-01T23:59:59.000Z

479

Crafting life : a sensory ethnography of fabricated biologies  

E-Print Network (OSTI)

This ethnography tracks a diverse set of practices I term "constructive biologies," by which I mean efforts in the post-genomic life sciences to understand how biology works by making new biological things. I examine five ...

Roosth, Hannah Sophia

2010-01-01T23:59:59.000Z

480

Aspects of the political economy of development and synthetic biology  

E-Print Network (OSTI)

What implications might synthetic biologys potential as a wholly new method of production have for the world economy, particularly developing countries? Theories of political economy predict that synthetic biology can ...

Wellhausen, Rachel

Note: This page contains sample records for the topic "molecular biology csmb" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Molecular Dynamics Simulation of Thermoset Fracture with ...  

Science Conference Proceedings (OSTI)

The effects of resin chain extensibility and dilution on fracture behavior are studied by testing a variety of molecular systems. The molecular bases for precursors...

482

The Development of New User REsearch Capabilities in Environmental Molecular Science  

NLE Websites -- All DOE Office Websites (Extended Search)

0654 0654 PNNL-16054 1 The Development of New User Research Capabilities in Environmental Molecular Science: Workshop Report Held August 1-2, 2006 W.R. Wiley Environmental Molecular Sciences Laboratory Richland, WA Executive Summary On August 1, and 2, 2006, 104 scientists representing 40 institutions including 24 Universities and 5 National Laboratories gathered at the W.R. Wiley Environmental Molecular Sciences Laboratory, a National scientific user facility, to outline important science challenges for the next decade and identify major capabilities needed to pursue advanced research in the environmental molecular sciences. EMSL's four science themes served as the framework for the workshop. The four science themes are 1) Biological Interactions and Interfaces, 2) Geochemistry/Biogeochemistry and Surface

483

1 EXERCISE III.2 A LABORATORY COURSE IN MEDICINAL CHEMISTRY INTRODUCING MOLECULAR MODELING  

E-Print Network (OSTI)

Abstract: A laboratory course in medicinal chemistry introducing molecular modeling. Molecular modeling is an important and useful tool in drug design and for predicting biological activity in library compounds. A wide variety of computer programs and methods have been developed to visualize the 3D geometry and to calculate the physicochemical properties of drugs. In this paper, we describe a practical approach to molecular modeling as a powerful tool to study structureactivity relationship in drugs such as antibacterials, hormones, and cholinergic and adrenergic agents. Early in the course, the students learn how to draw 3D structures and to use them to perform conformational and molecular analyses. Thus, they may compare drugs with similar pharmacological activities by superimposing their structures and evaluating geometry and physical properties.

Ivone Carvalho; Mnica T. Pupo; urea D. L. Borges; Lilian S. C. Bernardes

2006-01-01T23:59:59.000Z

484

Apparatus for molecular weight separation  

DOE Patents (OSTI)

The present invention relates generally to an apparatus and method for separating high molecular weight molecules from low molecular weight molecules. More specifically, the invention relates to the use of microdialysis for removal of the salt (low molecular weight molecules) from a nucleotide sample (high molecular weight molecules) for ESI-MS analysis. The dialysis or separation performance of the present invention is improved by (1) increasing dialysis temperature thereby increasing desalting efficiency and improving spectrum quality; (2) adding piperidine and imidazole to the dialysis buffer solution and reducing charge states and further increasing detection sensitivity for DNA; (3) using low concentrations (0-2.5 mM NH4OAc) of dialysis buffer and shifting the DNA negative ions to higher charge states, producing a nearly 10-fold increase in detection sensitivity and a slightly decreased desalting efficiency, (4) conducting a two-stage separation or (5) any combination of (1), (2), (3) and (4).

Smith, Richard D. (Richland, WA); Liu, Chuanliang (Haverhill, MA)

2001-01-01T23:59:59.000Z

485

Molecular Bond: EMSL's bimonthly newsletter  

NLE Websites -- All DOE Office Websites (Extended Search)

Email not displaying correctly? View it on the website. The Molecular Bond newsletter banner December 2013 Allison A. Campbell, EMSL Director I'm pleased to share with you the...

486

Analysis of molecular expression patterns and integration with other knowledge bases using probabilistic Bayesian network models  

Science Conference Proceedings (OSTI)

How can molecular expression experiments be interpreted with greater than ten to the fourth measurements per chip? How can one get the most quantitative information possible from the experimental data with good confidence? These are important questions whose solutions require an interdisciplinary combination of molecular and cellular biology, computer science, statistics, and complex systems analysis. The explosion of data from microarray techniques present the problem of interpreting the experiments. The availability of large-scale knowledge bases provide the opportunity to maximize the information extracted from these experiments. We have developed new methods of discovering biological function, metabolic pathways, and regulatory networks from these data and knowledge bases. These techniques are applicable to analyses for biomedical engineering, clinical, and fundamental cell and molecular biology studies. Our approach uses probabilistic, computational methods that give quantitative interpretations of data in a biological context. We have selected Bayesian statistical models with graphical network representations as a framework for our methods. As a first step, we use a nave Bayesian classifier to identify statistically significant patterns in gene expression data. We have developed methods which allow us to (a) characterize which genes or experiments distinguish each class from the others, (b) cross-index the resulting classes with other databases to assess biological meaning of the classes, and (c) display a gross overview of cellular dynamics. We have developed a number of visualization tools to convey the results. We report here our methods of classification and our first attempts at integrating the data and other knowledge bases together with new visualization tools. We demonstrate the utility of these methods and tools by analysis of a series of yeast cDNA microarray data and to a set of cancerous/normal sample data from colon cancer patients. We discuss extending our methods to inferring biological pathways and networks using more complex dynamic Bayesian networks.

Moler, Edward J.; Mian, I.S.

2000-03-01T23:59:59.000Z

487

Journal of Biological Engineering BioMed Central Review Authentic teaching and learning through synthetic biology  

E-Print Network (OSTI)

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Synthetic biology is an emerging engineering discipline that, if successful, will allow wellcharacterized biological components to be predictably and reliably built into robust organisms that achieve specific functions. Fledgling efforts to design and implement a synthetic biology curriculum for undergraduate students have shown that the co-development of this emerging discipline and its future practitioners does not undermine learning. Rather it can serve as the lynchpin of a synthetic biology curriculum. Here I describe educational goals uniquely served by synthetic biology teaching, detail ongoing curricula development efforts at MIT, and specify particular aspects of the emerging field that must develop rapidly in order to best train the next generation of synthetic biologists. Review Teaching opportunities and challenges specific to synthetic biology "Plant a carrot get a carrot, not a Brussels sprout " sings a musical theater character in The Fantasticks [1], aptly contrasting

Natalie Kuldell

2007-01-01T23:59:59.000Z

488

Coordination of Biological Select Agent Activities at Department...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

security posed by the possible use of biological weapons of mass destruction has led to an increase in research and development activities involving biological select...

489

Fuel Cell Technologies Office: Biological Hydrogen Production Workshop  

NLE Websites -- All DOE Office Websites (Extended Search)

Biological Hydrogen Biological Hydrogen Production Workshop to someone by E-mail Share Fuel Cell Technologies Office: Biological Hydrogen Production Workshop on Facebook Tweet about Fuel Cell Technologies Office: Biological Hydrogen Production Workshop on Twitter Bookmark Fuel Cell Technologies Office: Biological Hydrogen Production Workshop on Google Bookmark Fuel Cell Technologies Office: Biological Hydrogen Production Workshop on Delicious Rank Fuel Cell Technologies Office: Biological Hydrogen Production Workshop on Digg Find More places to share Fuel Cell Technologies Office: Biological Hydrogen Production Workshop on AddThis.com... Publications Program Publications Technical Publications Educational Publications Newsletter Program Presentations Multimedia Conferences & Meetings

490

Biological Weed Control at the Sherwood, Washington, Disposal...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Services Ecosystem Management Team Biological Weed Control at the Sherwood, Washington, Disposal Site Biological Weed Control at the Sherwood, Washington, Disposal Site...

491

KBase: DOE Systems Biology Knowledgebase | Argonne National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

KBase: DOE Systems Biology Knowledgebase KBase: DOE Systems Biology Knowledgebase KBase is a collaborative, community-driven effort designed to accelerate our understanding of...

492

Workshop on Neutron Scattering Applications in Structural Biology...  

NLE Websites -- All DOE Office Websites (Extended Search)

Workshop on Neutron Scattering Applications in Structural Biology Workshop on Neutron Scattering Applications in Structural Biology For the fourth consecutive year, NScD and JINS...

493

PNNLs integrated systems biology approach to understanding the...  

NLE Websites -- All DOE Office Websites (Extended Search)

PNNLs integrated systems biology approach to understanding the effects of exposure to low doses of ionizing radiation William F. Morgan, Biological Sciences Division, Pacific...

494

EMSL: Science: EMSL Scientific Grand Challenge: Membrane Biology  

NLE Websites -- All DOE Office Websites (Extended Search)

CHALLENGE: MEMBRANE BIOLOGY Membrane Biology GC Resources Meet the Team Advisory Committee What Are Cyanobacteria? Project Achievements In the News 2005-2007 Progress Report...

495

Theoretical-Experimental Molecular Engineering to Develop Nanodevices for Sensing Science  

E-Print Network (OSTI)

Molecular electrostatic potentials (MEPs) and vibrational electronics (vibronics) have developed into novel scenarios proposed by our group to process information at the molecular level. They along with the traditional current-voltage scenario can be used to design and develop molecular devices for the next generation electronics. Control and communication features of these scenarios strongly help in the production of smart devices able to take decisions and act autonomously in aggressive environments. In sensor science, the ultimate detector of an agent molecule is another molecule that can respond quickly and selectively among several agents. The purpose of this project is the design and development of molecular sensors based on the MEPs and vibronics scenarios to feature two different and distinguishable states of conductance, including a nano-micro interface to address and interconnect the output from the molecular world to standard micro-technologies. In this dissertation, theoretical calculations of the electrical properties such as the electron transport on molecular junctions are performed for the components of the sensor system. Proofs of concept experiments complement our analysis, which includes an electrical characterization of the devices and measurement of conductance states that may be useful for the sensing mechanism. In order to focus this work within the very broad array between nanoelectronic and molecular electronics, we define the new field of Molecular Engineering, which will have the mission to design molecular and atomistic devices and set them into useful systems. Our molecular engineering approach begins with a search for an optimum fit material to achieve the proposed goals; our published results suggest graphene as the best material to read signals from molecules, amplify the communication between molecular scenarios, and develop sensors of molecular agents with high sensitivity and selectivity. Specifically, this is possible in the case of sensors, thanks to the graphene atomic cross section (morphology), plasmonic surface (delocalized charge) and exceptional mechanical and electrical properties. Deliverables from this work are molecular devices and amplifiers able to read information encoded and processed at the molecular level and to amplify those signals to levels compatible with standard microelectronics. This design of molecular devices is a primordial step in the development of devices at the nanometer scale, which promises the next generation of sensors of chemical and biological agents molecularly sensitive, selective and intelligent.

Rangel, Norma Lucia

2011-05-01T23:59:59.000Z

496

Image/Time Series Mining Algorithms: Applications to Developmental Biology, Document Processing and Data Streams  

E-Print Network (OSTI)

Applications to Developmental Biology, Document ProcessingApplications to Developmental Biology, Document Processingto develop- mental biology, historical manuscript

Tataw, Oben Moses

2013-01-01T23:59:59.000Z

497

MSc Plant Biology Future Crops UCD School of Biology & Environmental Science  

E-Print Network (OSTI)

campus, close to Dublin city centre Extensive range of campus accommodation options. UCD College Ecological Significance of Different Photosynthetic Pathways Biological Atomic Force Microscopy The last

498

Rethinking biology instruction : the application of DNR-based instruction to the learning and teaching of biology  

E-Print Network (OSTI)

Ed. ). (1999). Modern biology. Austin, TX: Holt, RinehartCHAPTER 2: THE DNR INSTRUCTIONAL PRINCIPLES AND BIOLOGYCurrent biology instruction takes a prescriptive approach to

Maskiewicz, April Lee

2006-01-01T23:59:59.000Z

499

Molecular Weight & Energy Transport 7 September 2011  

E-Print Network (OSTI)

Molecular Weight & Energy Transport 7 September 2011 Goals · Review mean molecular weight · Practice working with diffusion Mean Molecular Weight 1. We will frequently use µ, µe, and µI (the mean molecular weight per particle, per free electron, and per ion, respectively). Let's practice computing

Militzer, Burkhard

500

Molecular Nanosprings for Protein-Based Nanorobotics  

E-Print Network (OSTI)

Molecular Nanosprings for Protein-Based Nanorobotics Mustapha Hamdi 1 , Antoine Ferreira 1 antoine.ferreira@ensi-bourges.fr , mavro@coe.neu.edu This paper presents a molecular mechanics study using a molecular dynamics software (NAMD2) for characterization of molecular elastic joints for bio nanorobotic

Mavroidis, Constantinos