National Library of Energy BETA

Sample records for modification factor emf

  1. EMF cover.final

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    melatonin was considered a possible hypothesis (see page 24). This idea provided motivation to conduct research addressing a possible link between EMF exposure and breast...

  2. Effects on Aquatic Organisms (EMF, Acoustics and Physical Interaction...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Aquatic Organisms (EMF, Acoustics and Physical Interaction) Effects on Aquatic Organisms (EMF, Acoustics and Physical Interaction) Effects on Aquatic Organisms (EMF, Acoustics and ...

  3. Effects on Aquatic Organisms (EMF, Acoustics and Physical Interaction) |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Aquatic Organisms (EMF, Acoustics and Physical Interaction) Effects on Aquatic Organisms (EMF, Acoustics and Physical Interaction) Effects on Aquatic Organisms (EMF, Acoustics and Physical Interaction) 59_emf_pnnl_copping_v3.ppt (1.88 MB) More Documents & Publications Effects on Aquatic Organisms (Acoustics and Toxicity) Effects on the Physical Environment (Hydrodynamics, and Water Quality Food Web) Categorizing and Evaluating the Effects of Stressors (all Conceptual

  4. Changes in gene expression following EMF exposure

    SciTech Connect (OSTI)

    Woloschak, G.E.; Paunesku, T.; Chang-Liu, C.M.; Loberg, L.; Gauger, J.; McCormick, D.

    1997-10-01

    Experiments were designed to examine the effects of electromagnetic field (EMF) exposure on specific gene expression, an effect that can be deleterious, beneficial, or neutral, depending on the long-term consequences; however, the proof of a reproducible, quantitative biological effect (such as change in gene expression) will lead to latter experiments aimed at determining the relative contribution of these changes to cellular consequences. Past work by ourselves and by others has shown that measures of gene expression are extremely sensitive indicators of the cellular and biological effects of ionizing radiation, with transcriptional changes being detected by exposure of cells to doses of {gamma}-rays as low as 0.01 cGy that have no pronounced cellular consequences. On the basis of this work, the authors hypothesized that measures of gene expression will be equally sensitive to EMF effects on cells.

  5. Development of an EMF Measurements Database, EMF Rapid Program, Project #5, Interim Report: April 1995-December 1996

    SciTech Connect (OSTI)

    T. Dan Bracken, Inc.

    1997-04-01

    The EMF measurement data sets in existence today were compiled with varying goals and techniques. Consequently, they have different information content as well as varying logical and physical structure. Future studies will continue to pursue varying goals and utilize techniques that cannot be known in advance. Primary goals for the EMF Measurements Database developed under the Department of Energy EMF RAPID Program are to develop a database structure that can accommodate the diversity of EMF data sets, provide guidance for production of future EMF data sets, and serve as an accessible repository of EMF measurement data. Specific objectives of the EMF Measurements Database are: o to preserve study descriptions, results and data; o to provide readily accessible, well-documented data; and o to facilitate communication among researchers. In addition, the EMF Measurements Database will encourage additional analysis of existing data sets, facilitate analysis of data from multiple projects, support design of new studies, and permit future issues in EMF exposure assessment to be addressed with existing data. Preservation of study descriptions and data is accomplished with a formal, but open, structure. Specifications have been developed for the various elements of the database. Each data set in the database is formally described by a metadata file. The structured metadata file describes the origin, development, logical and physical structure and distribution mechanism for each data set. The metadata for each data set is generated according to a specification developed for the EMF Measurements Database. The actual measurement data is contained in data Products for each data set. The number and type of data product will vary by data set. Most of the data products in the possession of the EMF Measurements Database are available for download from an Internet site. For some data sets, the data products will be maintained by other parties who may have their own access procedures

  6. Nuclear Energy Response in the EMF27 Study

    SciTech Connect (OSTI)

    Kim, Son H.; Wada, Kenichi; Kurosawa, Atsushi; Roberts, Matthew

    2014-03-25

    The nuclear energy response for mitigating global climate change across eighteen participating models of the EMF27 study is investigated. Diverse perspectives on the future role of nuclear power in the global energy system are evident in the broad range of nuclear power contributions from participating models of the study. In the Baseline scenario without climate policy, nuclear electricity generation and shares span 0 – 66 EJ/ year and 0 - 25% in 2100 for all models, with a median nuclear electricity generation of 39 EJ/year (1,389 GWe at 90% capacity factor) and median share of 9%. The role of nuclear energy increased under the climate policy scenarios. The median of nuclear energy use across all models doubled in the 450 ppm CO2e scenario with a nuclear electricity generation of 67 EJ/year (2,352 GWe at 90% capacity factor) and share of 17% in 2100. The broad range of nuclear electricity generation (11 – 214 EJ/year) and shares (2 - 38%) in 2100 of the 450 ppm CO2e scenario reflect differences in the technology choice behavior, technology assumptions and competitiveness of low carbon technologies. Greater clarification of nuclear fuel cycle issues and risk factors associated with nuclear energy use are necessary for understanding the nuclear deployment constraints imposed in models and for improving the assessment of the nuclear energy potential in addressing climate change.

  7. Transcription factors for modification of lignin content in plants

    DOE Patents [OSTI]

    Wang, Huanzhong; Chen, Fang; Dixon, Richard A.

    2015-06-02

    The invention provides methods for modifying lignin, cellulose, xylan, and hemicellulose content in plants, and for achieving ectopic lignification and, for instance, secondary cell wall synthesis in pith cells, by altered regulation of a WRKY transcription factor. Nucleic acid constructs for altered WRKY-TF expression are described. Transgenic plants are provided that comprise modified pith cell walls, and lignin, cellulose, and hemicellulose content. Plants described herein may be used, for example, as improved biofuel feedstock and as highly digestible forage crops.

  8. Toward a sensible EMF policy: One utility's approach

    SciTech Connect (OSTI)

    Palk, B.V. )

    1991-04-01

    Over the past three years, the Los Angeles Department of Water and Power (LADWP) has developed an open, proactive approach to address the electromagnetic fields (EMF) issue. Many things gave impetus to this approach: the public's increasing concern about possible health effects associated with EMF; litigation and other difficulties utilities experience when attempting to construct electric facilities; and media coverage fueling public concern about the issue. For LADWP, management of this issue involves a communications and a policy development effort, both of them significant. As an integral part of managing this issue, LADWP has taken steps to reduce fields associated with new projects on a case-by-case basis where economically justified, and supported EMF research, including support for a national EMF research program. Also, LADWP continues its full support for and participation in the Electric Power Research Institute's (EPRI) EMF research program. In the discussion here, references to EPRI reports, bulletins, and technical papers have intentionally been excluded, since their inclusion would overwhelm the footnotes to this paper. Finally, LADWP has purposefully sought additional guidance from other individuals and public policy agencies, many of whose works are cited here.

  9. Appearance of thermochemical emf in some conducting materials

    SciTech Connect (OSTI)

    Petrov, Y.S.; Maslikhov, V.V.; Shcheglov, V.D.

    1983-05-01

    The appearance of an emf in conductors when they are heated is described by the Seebeck and Thompson effects. If some part of the surface of a conductor is covered by a pyrotechnical material and ignited, then while the pyrotechnical material is burning and after it has burned, an emf arises at the ends of the conductor. The direction of the emf depends on the location of maximum temperature of the heated section of the conductor. If the heating is terminated for some time and started up again, then the emf and current appear again, with no necessity for re-application of the pyrotechnical material. Conductors of Nichrome, Constantan and tungsten, as well as graphite rods were studied with small sections of the conductors covered with lead azide, black gunpowder, or match-head composition. The current ranged from -5 to 6 microamps, and the emf from -0.4 to 1 millivolt. The effects described can be used to convert thermal energy into electrical energy in sensors, etc.

  10. Technology and U.S. Emissions Reductions Goals: Results of the EMF 24 Modeling Exercise

    SciTech Connect (OSTI)

    Clarke, Leon E.; Fawcett, Allen; Weyant, John; McFarland, Jim; Chaturvedi, Vaibhav; Zhou, Yuyu

    2014-09-01

    This paper discusses Technology and U.S. Emissions Reductions Goals: Results of the EMF 24 Modeling Exercise

  11. Getting from here to there – energy technology transformation pathways in the EMF-27 scenarios

    SciTech Connect (OSTI)

    Krey, Volker; Luderer, Gunnar; Clarke, Leon E.; Kriegler, Elmar

    2014-04-01

    This apper discusses Getting from here to there – energy technology transformation pathways in the EMF-27 scenarios

  12. Joint HVAC transmission EMF environmental study

    SciTech Connect (OSTI)

    Stormshak, F.; Thompson, J. )

    1992-05-01

    This document describes the rationale, procedures, and results of a carefully controlled study conducted to establish whether chronic exposure of female (ewe) Suffolk lambs to the environment of a 500-kV 60-Hz transmission line would affect various characteristics of growth, endocrine function, and reproductive development. This experiment used identical housing and management schemes for control and line-exposed ewes, thus minimizing these factors as contributors to between-group experimental error. Further, throughout the 10-month duration of this study, changes in electric and magnetic fields, audible noise, and weather conditions were monitored continuously by a computerized system. Such measurements provided the opportunity to identify any relationship between environmental factors and biological responses. Because of reports in the literature that electric and magnetic fields alter concentrations of melatonin in laboratory animals, the primary objective of this study was to ascertain whether a similar effect occurs in lambs exposed to a 500-kV a-c line in a natural setting. In addition, onset of puberty, changes in body weight, wool growth, and behavior were monitored. To determine whether the environment of a 500-kV line caused stress in the study animals, serum levels of cortisol were measured. The study was conducted at Bonneville Power Administration's Ostrander Substation near Estacada, Oregon.

  13. The process of consensus on EMF: SAB review of the EPA draft document on EMF and cancer

    SciTech Connect (OSTI)

    Wilson, B.W.

    1992-06-01

    The EPA Draft Document on EMF and Cancers grew out of an earlier effort by EPA to track biological effects literature relative to radio-frequency (RF) exposure. Scope of the document was broadened to include extremely low frequency electric and magnetic fields prior to an announcement in 1986 that EPA would formally review the whole area of non-ionizing radiation. An extensive survey of the relevant bioeffects and epidemiologic literature was carried out, and writing on the document began in earnest on the document sometime in 1989. In its draft form, the document reviewed the literature on mechanisms of Interaction between electromagnetic fields and biological tissue, EMF epidemiologic studies, supporting evidence for carcinogenicity and research needs. In the early summer of 1990, a draft of the document was reviewed by some 22 individuals within the EPA and other government agencies. It was also sent out for external review to an additional 9 qualified scientists who had worked in the area and were familiar with EMF-related literature in epidemiology, biology, and physics. Many of the comments sent to EPA from this first review, prior to release of the draft for public comment, were strikingly similar to those resulting from the second (public) review process. Thus, it appears that much of the controversy that was later associated with the document could have been avoided had the authors been diligent in following the recommendations of the initial set of reviewers.

  14. ETA-HTP09 - Measurement and Evaluation of Magnetic Fields (EMF...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Measurement and Evaluation of Magnetic Fields (EMF) and Electromagnetic Radiation (EMI) ... 3 6. Magnetic Field and Electromagnetic Radiation 6.1 Magnetic Field Measurement Procedure ...

  15. Environmental Field Surveys, EMF Rapid Program, Engineering Project No.3

    SciTech Connect (OSTI)

    Enertech Consultants

    1996-04-01

    The EMF Research and Public Information Dissemination Program (RAPID) includes several engineering research in the area of exposure assessment and source characterization. RAPID engineering project No. 3: ''Environmental Field Surveys'' was performed to obtain information on the levels and characteristics of different environments, for which only limited data were available, especially in comparison to magnetic field data for the residential environment and for electric utility facilities, such as power lines and substations. This project was also to provide information on the contribution of various field sources in the surveyed environments. Magnetic field surveys were performed at four sites for each of five environments: schools, hospitals, office buildings, machine shops, and grocery stores. Of the twenty sites surveyed, 11 were located in the San Francisco Bay Area and 9 in Massachusetts. The surveys used a protocol based on magnetic field measurements and observation of activity patterns, designed to provide estimates of magnetic field exposure by type of people and by type of sources. The magnetic field surveys conducted by this project produced a large amount of data which will form a part of the EMF measurement database Field and exposure data were obtained separately for ''area exposure'' and ''at exposure points''. An exposure point is a location where persons engage in fixed, site specific activities near a local source that creates a significant increase in the area field. The area field is produced by ''area sources'', whose location and field distribution is in general not related to the location of the people in the area.

  16. EMF RAPID Program research agenda and communication plan

    SciTech Connect (OSTI)

    Not Available

    1994-05-01

    The driving force behind the Electric and Magnetic Fields (EMF) Research and Public Information Dissemination (RAPID) Program, established by Section 2118 of the Energy Policy Act of 1992, is the ``sense of the Congress that remedial action taken by the Government on electric and magnetic fields, if and as necessary, should be based on, and consistent with, scientifically valid research...`` Specifically, the legislation requires the development of a comprehensive program to: determine whether or not exposure to electric and magnetic fields produced by the generation, transmission, and use of electric energy affects human health; carry out research, development, and demonstration with respect to technologies to mitigate any adverse human health effects; and provide for the collection, compilation, publication, and dissemination of scientifically valid information to the public on the following subjects: (a) possible human health effects of electric and magnetic fields; (b) the types and extent of human exposure to electric and magnetic fields in various occupational and residential settings; (c) technologies to measure and characterize electric and magnetic fields; and (d) methods to assess and manage exposure to electric and magnetic fields. The Department of Energy (DOE) is responsible for the overall administration of the 5-year, and $65 million EMF RAPID Program. The program will be jointly funded by both Federal non-Federal sources with non-Federal contributions accounting for at least 50% of the total funding.

  17. Electric and Magnetic Fields (EMF) RAPID Engineering Program, Project 7: Development of Field Exposure Models

    SciTech Connect (OSTI)

    Bracken, T.D.; Rankin, R.F.; Wiley, J.A.

    1999-05-01

    The purpose of this project was to develop a conceptual model for estimating magnetic field (EMF) personal exposure (PE) of individuals or groups and construct a working model using existing data.

  18. Recommendations for Guidelines for EMF Personal Exposure Measurements, Rapid Project #4

    SciTech Connect (OSTI)

    T. Dan Bracken, Inc.

    1997-08-01

    The purpose of developing guidelines for electric and magnetic field (EMF) personal exposure measurements (lF'EM) is to ensure reliable and comparable data across I?EM studies. Study techniques may vary due to different populations or objectives, but the resulting data should be consistently reported and comparable, to the extent possible. Any guideline must allow creativity by the research-oriented investigator and provide specific guidance to industrial hygienists or other results-oriented investigators, requiring a standard protocol. Recognizing measurement studies with different purposes is an important aspect of these recommendations. The guidelines presented here intend to produce comparable data across studies while remaining flexible. The recommendations for designing and implementing an EMF PEM program describe a three-stage process. The first step is to clearly state the purpose of the PEM program. The next stage addresses the fundamental elements of an EMF PEM study, including an assessment of the scientific and organizational resources that will be required. This process is codified in a written study plan. These stages are described in 1 Section 5 of this report. The third stage of a PEM study involves the design, implementation and documentation of specific procedures and protocols fo~ sampling strategies, selection of measurement parameters; instrumentation, measurement and data collection, data management, data analysis, quality assurance, uncertainty evaluation, and archiving the study methods and results. The methods for designing these elements of an EMF PEM study are described in Section 6: Specific Guidelines for EMF I?EM Study Design.

  19. Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Dogan, Nergiz; Wu, Weisheng; Morrissey, Christapher S.; Chen, Kuan-Bei; Stonestrom, Aaron; Long, Maria; Keller, Cheryl A.; Cheng, Yong; Jain, Deepti; Visel, Axel; et al

    2015-04-23

    Regulated gene expression controls organismal development, and variation in regulatory patterns has been implicated in complex traits. Thus accurate prediction of enhancers is important for further understanding of these processes. Genome-wide measurement of epigenetic features, such as histone modifications and occupancy by transcription factors, is improving enhancer predictions, but the contribution of these features to prediction accuracy is not known. Given the importance of the hematopoietic transcription factor TAL1 for erythroid gene activation, we predicted candidate enhancers based on genomic occupancy by TAL1 and measured their activity. Contributions of multiple features to enhancer prediction were evaluated based on the resultsmore » of these and other studies. Results: TAL1-bound DNA segments were active enhancers at a high rate both in transient transfections of cultured cells (39 of 79, or 56%) and transgenic mice (43 of 66, or 65%). The level of binding signal for TAL1 or GATA1 did not help distinguish TAL1-bound DNA segments as active versus inactive enhancers, nor did the density of regulation-related histone modifications. A meta-analysis of results from this and other studies (273 tested predicted enhancers) showed that the presence of TAL1, GATA1, EP300, SMAD1, H3K4 methylation, H3K27ac, and CAGE tags at DNase hypersensitive sites gave the most accurate predictors of enhancer activity, with a success rate over 80% and a median threefold increase in activity. Chromatin accessibility assays and the histone modifications H3K4me1 and H3K27ac were sensitive for finding enhancers, but they have high false positive rates unless transcription factor occupancy is also included. Conclusions: Occupancy by key transcription factors such as TAL1, GATA1, SMAD1, and EP300, along with evidence of transcription, improves the accuracy of enhancer predictions based on epigenetic features.« less

  20. Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility

    SciTech Connect (OSTI)

    Dogan, Nergiz; Wu, Weisheng; Morrissey, Christapher S.; Chen, Kuan-Bei; Stonestrom, Aaron; Long, Maria; Keller, Cheryl A.; Cheng, Yong; Jain, Deepti; Visel, Axel; Pennacchio, Len A.; Weiss, Mitchell J.; Blobel, Gerd A.; Hardison, Ross C.

    2015-04-23

    Regulated gene expression controls organismal development, and variation in regulatory patterns has been implicated in complex traits. Thus accurate prediction of enhancers is important for further understanding of these processes. Genome-wide measurement of epigenetic features, such as histone modifications and occupancy by transcription factors, is improving enhancer predictions, but the contribution of these features to prediction accuracy is not known. Given the importance of the hematopoietic transcription factor TAL1 for erythroid gene activation, we predicted candidate enhancers based on genomic occupancy by TAL1 and measured their activity. Contributions of multiple features to enhancer prediction were evaluated based on the results of these and other studies. Results: TAL1-bound DNA segments were active enhancers at a high rate both in transient transfections of cultured cells (39 of 79, or 56%) and transgenic mice (43 of 66, or 65%). The level of binding signal for TAL1 or GATA1 did not help distinguish TAL1-bound DNA segments as active versus inactive enhancers, nor did the density of regulation-related histone modifications. A meta-analysis of results from this and other studies (273 tested predicted enhancers) showed that the presence of TAL1, GATA1, EP300, SMAD1, H3K4 methylation, H3K27ac, and CAGE tags at DNase hypersensitive sites gave the most accurate predictors of enhancer activity, with a success rate over 80% and a median threefold increase in activity. Chromatin accessibility assays and the histone modifications H3K4me1 and H3K27ac were sensitive for finding enhancers, but they have high false positive rates unless transcription factor occupancy is also included. Conclusions: Occupancy by key transcription factors such as TAL1, GATA1, SMAD1, and EP300, along with evidence of transcription, improves the accuracy of enhancer predictions based on epigenetic features.

  1. The role of renewable energy in climate stabilization: results from the EMF 27 scenarios

    SciTech Connect (OSTI)

    Luderer, Gunnar; Krey, Volker; Calvin, Katherine V.; Merrick, James; Mima, Silvana; Pietzcker, Robert; Van Vliet, Jasper; Wada, Kenichi

    2013-10-15

    This paper uses the EMF27 scenarios to explore the role of renewable energy (RE) in climate change mitigation. Currently RE supplies almost 20 % of global electricity demand. Almost all EMF27 mitigation scenarios show a strong increase in renewable power production, with a substantial ramp-up of wind and solar power deployment. In many scenarios, renewables are the most important long-term mitigation option for power supply. Wind energy is competitive even without climate policy, whereas the prospects of solar photovoltaics (PV) are highly contingent on the ambitiousness of climate policy. Bioenergy is an important and versatile energy carrier; howeverwith the exception of low temperature heatthere is less scope for renewables other than biomass for non-electric energy supply. Despite the important role of wind and solar power in climate change mitigation scenarios with full technology availability, limiting their deployment has a relatively small effect on mitigation costs, if nuclear and carbon capture and storage (CCS)which can serve as substitutes in low-carbon power supplyare available. Limited bioenergy availability in combination with limited wind and solar power by contrast, results in a more substantial increase in mitigation costs. While a number of robust insights emerge, the results on renewable energy deployment levels vary considerably across the models. An in-depth analysis of a subset of EMF27 reveals substantial differences in modeling approaches and parameter assumptions. To a certain degree, differences in model results can be attributed to different assumptions about technology costs, resource potentials and systems integration.

  2. Visionary Solutions Contract Modifications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Visionary Soultions LLC Contract DE-EM0001840 Modifications Modification 001 Modification 0001 DE-DT0004203 Modification 0001 DE-DT0007810 Modification 0001 DE-DT0005972 Modification 002 Modification 0003 Modification 0004 Modification 0006

  3. Portage Contract Modifications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Portage, Inc. Contract DE-DT0001674 Modifications Portage Modification 001 Portage Modification 002 Portage Modification 003 Portage Modification 004 Portage Modification 005 Portage Modification 006 Portage Modification 007 Portage Modification 008 Portage Modification 065 Portage Modification 066 Portage Modification 067

  4. Low-cost, compact, robust laser-based ultrasound sensors using photo-EMF detection

    SciTech Connect (OSTI)

    Pepper, D.M.; Dunning, G.J.; Chiao, M.P.; O`Meara, T.R.; Mitchell, P.V.

    1996-12-31

    There is a great need in the manufacturing, aerospace, commercial, energy, automotive, microelectronics and DoD communities for diagnostic systems that can improve the efficiency, yield and performance of various materials processes--while reducing cost, labor, scrap, and machine downtime. Laser-based ultrasound (LBU) represents a noncontact, reconfigurable, high-bandwidth ultrasonic inspection and process control technology. LBU enables remote ultrasonic sensing by replacing conventional PZT transducers, squirters, and immersion systems with laser beams. One laser beam generates the ultrasound in an opaque workpiece, while a second laser beam probes the sample to sense minute surface displacements, induced by the ultrasound or via other acoustic emission mechanisms. LBU systems have yet to be fielded commercially, owing primarily to the cost, size, and complexity of the system components. The authors have developed a low-cost, compact sensor which can potentially enable LBU systems to become a reality. The sensor employs a semiconductor crystal (GaAs) using a mechanism called nonsteady-state photo-induced emf. When combined with a laser diode as an optical source, the result is a very compact, low-cost robust sensor, which can function under in-factory conditions, including inspection of rough-cut workpieces which undergo rapid platform motion, such as high-speed, scanning laser welders. Experimental results will be discussed, including the potential for optical fiber delivery.

  5. Nuclear Waste Partnership Contract Modifications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Waste Partnership Contract DE-EM0001971 Modifications NWP Modification Index Description Modification 001 Modification 002 Modification 003 Modification 004 Modification 005...

  6. Thermodynamic behavior of high-T sub c oxide systems via EMF and related measurements

    SciTech Connect (OSTI)

    Tetenbaum, M.; Tumidajaski, P.; Bloom, I.D.; Brown, D.L.; Blander, M.

    1991-01-01

    EMF measurements of oxygen fugacities as a function of stoichiometry have been made in the YBa{sub 2}Cu{sub 3}O{sub x}, and NdBa{sub 2}Cu{sub 3}O{sub x}, and Nd{sub 1.81}Ce{sub 0.19}CuO{sub x} superconducting systems in the temperature range 400--750{degree}C by means of an oxygen titration technique with an yttria-stabilized zirconia electrolyte. The object of our current measurements is to investigate the effect of ionic size of Y, Gd and Nd on the thermodynamic behavior and structural transition in the LnBa{sub 2}Cu{sub 3}O{sub x} system. The shape of the 400{degree}C isotherm for NdBa{sub 2}Cu{sub 3}O{sub x} suggests the presence of a miscibility gap at lower temperatures, at values of x that are higher than those in the YBa{sub 2}Cu{sub 3}O{sub x} system. The locations of the miscibility gaps are consistent with the effects of ionic radii on the composition dependence of {Tc} for these systems. Our results explain the two plateaus in measured value of {Tc} as a function of composition for the YBa{sub 2}Cu{sub 3}O{sub x} system and appear to be consistent with the less pronounced {Tc} plateaus found for the NdBa{sub 2}Cu{sub 3}O{sub x} system higher stoichiometry values. For a given oxygen stoichiometry, partial pressures of oxygen above NdBa{sub 2}Cu{sub 3}O{sub x} are higher than for the YBa{sub 2}Cu{sub 3}O{sub x} system in accord with calculated partial molar thermodynamic quantities. The results of limited measurements on the n-type (electron-doped) superconducting Nd{sub 1.81}Ce{sub 0.19}CuO{sub x} system will be presented. A thermodynamic assessment and intercomparison of our oxygen partial pressure measurements with the results of other measurements will be presented. 34 refs., 9 figs., 1 tab.

  7. Thermodynamic and nonstoichiometric behavior of promising Hi-Tc cuprate systems via EMF measurements : a short review.

    SciTech Connect (OSTI)

    Tetenbaum, M.

    1999-02-24

    Electromotive force (EMF) measurements of oxygen fugacities as a function of stoichiometry have been made on the YBa{sub 2}Cu{sub 3}O{sub x}, GdBa{sub 2}Cu{sub 3}O{sub x}, NdBa{sub 2}Cu{sub 3}O{sub x} and bismuth cuprate systems in the temperature range {approximately}400-750 C by means of an oxygen titration technique with an yttria-stabilized zirconia electrolyte. The shapes of the 400 C isotherms as a function of oxygen stoichiometry for the Gd and Nd cuprate systems suggest the presence of miscibility gaps at values of x that are higher than those in the YBa{sub 2}Cu{sub 3}O{sub x} system. For a given oxygen stoichiometry, oxygen partial pressures above GdBa{sub 2}Cu{sub 3}O{sub x} and NdBa{sub 2}Cu{sub 3}O{sub x} are higher (above x=6.5) than that for the promising YBa{sub 2}Cu{sub 3}O{sub x} system. A thermodynamic assessment and intercomparison of our partial pressure measurements with the results of related measurements will be presented.

  8. Joint HVAC Transmission EMF Environmental Study : Final Report on Experiment 1.

    SciTech Connect (OSTI)

    United States. Bonneville Power Administration; Oregon Regional Primate Research Center

    1992-05-01

    This document describes the rationale, procedures, and results of a carefully controlled study conducted to establish whether chronic exposure of female (ewe) Suffolk lambs to the environment of a 500-kV 60-Hz transmission line would affect various characteristics of growth, endocrine function, and reproductive development. This experiment used identical housing and management schemes for control and line-exposed ewes, thus minimizing these factors as contributors to between-group experimental error. Further, throughout the 10-month duration of this study, changes in electric and magnetic fields, audible noise, and weather conditions were monitored continuously by a computerized system. Such measurements provided the opportunity to identify any relationship between environmental factors and biological responses. Because of reports in the literature that electric and magnetic fields alter concentrations of melatonin in laboratory animals, the primary objective of this study was to ascertain whether a similar effect occurs in lambs exposed to a 500-kV a-c line in a natural setting. In addition, onset of puberty, changes in body weight, wool growth, and behavior were monitored. To determine whether the environment of a 500-kV line caused stress in the study animals, serum levels of cortisol were measured. The study was conducted at Bonneville Power Administration`s Ostrander Substation near Estacada, Oregon.

  9. EMF Rapid Program Engineering Projects, Project 1, Development of Recommendations for Guidelines for Field Source Measurement

    SciTech Connect (OSTI)

    Electric Research and Management, Inc.

    1997-03-11

    The goal of this project is to develop a protocol for measuring the electric and magnetic fields around sources. Data from these measurements may help direct future biological effects research by better defining the complexity of magnetic and electric fields to which humanity is exposed, as well asprovide the basis for rigorous field exposure analysis and risk assessment once the relationship between field exposure and biological response. is better understood. The data base also should have sufficient spatial and temporal characteristics to guide electric and magnetic field management. The goal of Task A is to construct a set of characteristics that would be ideal to have for guiding and interpreting biological studies and for focusing any future effort at field management. This ideal set will then be quantified and reduced according to the availability (or possible development of) instrumentation to measure the desired characteristics. Factors that also will be used to define pragmatic data sets will be the cost of collecting the data, the cost of developing an adequate data base, and the needed precision in measuring specific characteristics. A field, electric or magnetic, will always be ,some function of time and space. The first step in this section of the protocol development will be to determine what span of time and what portion of space are required to quantify the electric and magnetic fields around sources such as appliances and electrical apparatus. Constraints on time will be set by examining measurement limitations and biological data requirements.

  10. ICP Contract Modifications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SPECTRA TECH INC (STI) Modifications to Contract No. DE-EM0003976 You are here: DOE-ID Home > Contracts, Financial Assistance & Solicitations > STI Contract > STI Modifications Blue Line Free Acrobat Reader Link The documents listed below represent an electronic copy of modifications to the contract for the Spectra Tech, Inc. (STI). These documents are in PDF format. The Adobe Reader is required to access them. If you do not currently have the Acrobat Reader, you may download the

  11. Modification of chemical and physical factors in steamflood to increase heavy oil recovery. Annual report, October 1, 1991--September 30, 1992

    SciTech Connect (OSTI)

    Yortsos, Y.C.

    1993-07-01

    This report covers work performed in the various physicochemical factors for the improvement of oil recovery efficiency. In this context, three general areas were studied: (i) The understanding of vapor-liquid flow in porous media, whether the flow is internal (boiling), external (steam injection) or countercurrent (as in vertical heat pipes); (ii) The effect of reservoir heterogeneity, particularly as it regards fractured systems; (iii) The flow properties of additives for the improvement of recovery efficiency, in particular the injection of caustic and foams. The studies completed under this contract involved ap three research tools, analysis, computation and experiments. We have focused on pore level modeling using pore networks and on flow visualization using Hele-Shaw cells. Experiments involving core samples were conducted for the chemical additives investigation. Finally, simulation at the pore scale, pore network scale and reservoir scale were also undertaken. Part of the work has been detailed in five DOE Technical Reports as shown at the end of this report.

  12. Permit application modifications

    SciTech Connect (OSTI)

    1995-11-01

    This document contains the Permit Application Modifications for the Y-12 Industrial Landfill V site on the Oak Ridge Reservation. These modifications include the assessment of stability of the proposed Landfill V under static and loading conditions. Analyses performed include the general slope stability, veneer stability of the bottom liner and cover system, and a liquefaction potential assessment of the foundation soils.

  13. ICP Contract Modifications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Modifications to Contract No. DE-AC07-05ID14516 You are here: DOE-ID Home > Contracts, Financial Assistance & Solicitations > ICP Contract > ICP Modifications Blue Line Free Acrobat Reader Link The documents listed below represent an electronic copy of modifications to the contract for the Idaho Cleanup Project (ICP). These documents are in PDF format. The Adobe Reader is required to access them. If you do not currently have the Acrobat Reader, you may download the Reader FREE by

  14. ICP Contract Modifications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Core Modifications to Contract No. DE-EM0004083 You are here: DOE-ID Home > Contracts, Financial Assistance & Solicitations > ICP-Core Contract > ICP-Core Modifications Blue Line Free Acrobat Reader Link The documents listed below represent an electronic copy of modifications to the contract for the Idaho Cleanup Project (ICP) Core. These documents are in PDF format. The Adobe Reader is required to access them. If you do not currently have the Acrobat Reader, you may download the

  15. INL Contract Modifications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Modifications to Contract No. DE-AC07-05ID14517 You are here: DOE-ID Home > Contracts, Financial Assistance & Solicitations > INL Contract > INL Basic Modifications Blue Line Free Acrobat Reader Link The documents listed below represent an electronic copy of modifications to the contract for the Management and Operation of the INL awarded to Battelle Energy Alliance, LLC. These documents are in PDF format. The Adobe Reader is required to access them. If you do not currently have the

  16. ATL Contract Modifications - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Contract Modifications Office of River Protection ORP Contracts & Procurements Home DOE-ORP Contract Management Plans DOE-ORP Prime Contracts BNI Contract BNI Contract Modifications ATL Contract ATL Contract Modifications WRPS Contract WRPS Contract Modifications CH2M Contract CH2M Contract Modifications WAI Contract WAI Contract Mods DOE-ORP Contracting Officers DOE ORP Contracting Officer Representatives DOE ORP Purchase Card Buyers ATL Contract Modifications Email Email Page | Print Print

  17. Modification No. M074

    National Nuclear Security Administration (NNSA)

    No. M074 Page 2 of 2 BWXT Pantex, LLC Contract No. DE-AC-04AL:66620 1. Appendix D, "Key Personnel," dated October 13, 2003, that is currently in Section J of the Contract is hereby deleted in its entirety and replaced with Appendix D, "Key Personnel," dated August 23, 2004 (Attachment 1 of this Modification). 2. Section C of the Contract is modified to add paragraph 6.5, "Workers Compensation Matters ." This paragraph is stated below in its entirety. 6.5 Workers

  18. Modifications to Replacement Costs System

    SciTech Connect (OSTI)

    Godec, M. [ICF Resources, Inc., Fairfax, VA (United States)

    1989-05-18

    The purpose of this memorandum is to document the improvements and modifications made to the Replacement Costs of Crude Oil (REPCO) Supply Analysis System. While some of this work was performed under our previous support contract to DOE/ASFE, we are presenting all modifications and improvements are presented here for completeness. The memo primarily documents revisions made to the Lower-48 Onshore Model. Revisions and modifications made to other components and models in the REPCO system which are documented elsewhere are only highlighted in this memo. Generally, the modifications made to the Lower-48 Onshore Model reflect changes that have occurred in domestic drilling, oil field costs, and reserves since 1982, the date of the most recent available data used for the original Replacement Costs report, published in 1985.

  19. Radiation Damage/Materials Modification

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    radiation damage materials modification Radiation Damage/Materials Modification High-energy ion irradiation is an important tool for studying radiation damage effects Materials in a nuclear reactor are exposed to extreme temperature and radiation conditions that degrade their physical properties to the point of failure. For example, alpha-decay in nuclear fuels results in dislocation damage to and accumulation of helium and fission gasses in the material. Similarly, neutrons interacting with

  20. Modifications improve waterflood performance model

    SciTech Connect (OSTI)

    El-Banbi, A.H.; Abdel Wally, A.; Abd-el Fattah, K.A.; Sayyouh, M.H.

    1996-01-01

    Modifications to the Craig-Geffen-Morse (CGM) waterflooding model improve reservoir performance predictions and allow for the inclusion of pressure drop variations with time. The modified model was validated against numerical simulation results. The paper describes the CGM model, the hypothetical data set, the simulation technique, comparisons between the CGM model and the simulation, and modifications to the CGM model relating to pressure drop variation and water production.

  1. Class 1 Permit Modification Notification

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Waste Bureau New Mexico Environment Department 2905 Rodeo Park Drive East, Bu il ding 1 Santa Fe, New Mexico 87505-6303 JUL 0 5 2011 Subject: Notification of a Class 1 Permit Modification to the Hazardous Waste Facility Permit, Permit Number: NM4890139088-TSDF Dear Mr. Kieling : Enclosed is a Class 1 Permit Modification Notification 1 0: * Update Emergency Coordinator list We certify under penalty of law that this document and the enclosure were prepared under our direction or supervision in

  2. Oregon Modification Application Geothermal Wells Form | Open...

    Open Energy Info (EERE)

    Modification Application Geothermal Wells Form Jump to: navigation, search OpenEI Reference LibraryAdd to library Form: Oregon Modification Application Geothermal Wells Form Form...

  3. Penser Contract Modifications (EM0003383) - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Contract Modifications (EM0003383) DOE-RL ContractsProcurements RL Contracts & ... Officer Representatives Penser Contract Modifications (EM0003383) Email Email ...

  4. WIPP Hazardous Waste Permit - Class 1* (star) Modifications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    * (star) Modifications Submitted for NMED Approval

  5. Class 1 Permit Modification Notifications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Class 1 Permit Modification Notifications Editorial Changes in Monitoring Records Text in Part 1 Editorial Changes in Attachment C6 and Attachment C3 Update Table L-4 and List of Active Environmental Permits Clarify Text Related to Marking and Labeling Packages in Part 3 Clarify Table E-1a Revise Table 4.1.1 Revise Table G-1 Waste Isolation Pilot Plant Carlsbad, New Mexico NM4890139088-TSDF February 2014 Table of Contents Transmittal Letter Table of Contents

  6. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (Specify type of modification and authority) E.IMPORTANT: contractor---isnot. -isrequ:irn:dtosignthisdocum:enta:ndr:et:u...

  7. Nanoparticle modifications of photodefined nanostructures for...

    Office of Scientific and Technical Information (OSTI)

    Country of Publication: United States Language: English Subject: 77 NANOSCIENCE AND NANOTECHNOLOGY; CARBON; ELECTRODES; FABRICATION; MODIFICATIONS; NANOSTRUCTURES; POLYMERS Word ...

  8. Chapter 43 - Contract Modifications | Department of Energy

    Office of Environmental Management (EM)

    3 - Contract Modifications Chapter 43 - Contract Modifications 43.1 Contract Modification.pdf (56.06 KB) AcqGuide43.2_ 1 August 2013_CLEAN.pdf (159.84 KB) 43.3_Maintaining Alignment of Project Mgmt with Contract Mgmt.pdf (419.42 KB) More Documents & Publications Acquisition Guide Chapter 43.3 Acquisition Guide Chapter 43.2: Change Order Administration Acquisition Guide Chapter 43.1, Contract Modifications

  9. Energy conservation potential of surface modification technologies

    SciTech Connect (OSTI)

    Le, H.K.; Horne, D.M.; Silberglitt, R.S.

    1985-09-01

    This report assesses the energy conservation impact of surface modification technologies on the metalworking industries. The energy conservation impact of surface modification technologies on the metalworking industries is assessed by estimating their friction and wear tribological sinks and the subsequent reduction in these sinks when surface modified tools are used. Ion implantation, coatings, and laser and electron beam surface modifications are considered.

  10. WIPP - Information on Proposed Permit Modifications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    WIPP Hazardous Waste Facility Permit RCRA Proposed Permit Modifications (Drafts) Draft Class 3 Permit Modification Request Addition of a Concrete Overpack Container Storage Unit dated August 2016 Fact Sheets Public Notices Please forward comments to the following email address: Draft.ModificationResponse@. These Documents are NOT FINAL and have not been formally submitted to the permitting authority for approval. These Documents are subject to future change at the discretion of the U.S.

  11. Modifications for Public Comment - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MP-14 WIDS Information Hanford Site Waste Management Units Report Hanford Public Involvement Plan Administrative Record (AR) Related Links Modifications for Public Comment...

  12. CXD_4603, Enclosure Modification Project (4603)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Enclosure Modification Project (4603) Y-12 Site Office Oak Ridge, Anderson County, Tennessee The proposed action is to convert the temporary enclosure to a permanent enclosure....

  13. DOE IDIQ ESPC Contract Modifications | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    IDIQ ESPC Contract Modifications DOE IDIQ ESPC Contract Modifications Amendment of Solicitation/Modification of Contract forms for the U.S. Department of Energy (DOE) indefinite-delivery, indefinite-quantity (IDIQ) energy savings performance contract (ESPC). Modifications in these forms apply to all energy service companies (ESCOs). Individual ESCO modifications are not included. The date the modifications were signed are in parentheses below. See the DOE IDIQ ESPC Contract Sample. Modification

  14. Firearms Modifications List- June 13, 2012

    Office of Energy Efficiency and Renewable Energy (EERE)

    This document contains the currently-approved protective force "Firearms Modification List" referred to in Department of Energy Order 473.3, Protection Program Operations. This supersedes any previous versions of this document

  15. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    National Nuclear Security Administration (NNSA)

    CODE FACILITY CODE 10A. MODIFICATION OF CONTRACTORDER NO. DE-AC04-94AL85000 10B. DATED ... OF CONTRACTSORDERS. IT MODIFIES THE CONTRACTORDER NO. AS DESCRIBED IN ITEM 14. CHECK ...

  16. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    National Nuclear Security Administration (NNSA)

    , 1. CONTRACT ID CODE I PAGE OF PAGES 1 I 2 2. AMENDMENTMODIFICATION NO. 3. EFFECTIVE ... (SEE ITEM 11) x 10A. MODIFICATION OF CONTRACTORDER NO. DE-AC52-06NA25396 10B. DATED ...

  17. Surface and interface modification science and technology.

    SciTech Connect (OSTI)

    Park, J.-H.

    1999-07-19

    Surface modification of solids is of scientific and technological interest due to its significant benefits in a wide variety of applications. Various coatings applications such as corrosion protection and electrical insulators and conductors are required for proper engineering design based on geometrical relationships between interfaces and on thermodynamic/kinetic considerations for the development of surface modifications. This paper will explore three basic examples: the proton conductor BaCeO{sub 3}, high-temperature protective coatings, and epitaxial relationships between interfaces.

  18. Fuel Modification t Facilitate Future Combustion Regimes? | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Modification t Facilitate Future Combustion Regimes? Fuel Modification t Facilitate Future ... Merit Review 2015: RCM Studies to Enable Gasoline-Relevant Low Temperature Combustion

  19. WIPP Hazardous Waste Permit - Incorporated Class 1 Modifications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Modifications Submitted for Incorporation into the Permit Class 1 Permit Modification - Change in Department of Energy, Carlsbad Field Office Manager, October 12, 2010 Class 1...

  20. Modifications to WRFs dynamical core to improve the treatment...

    Office of Scientific and Technical Information (OSTI)

    Modifications to WRFs dynamical core to improve the treatment of moisture for large-eddy simulations Title: Modifications to WRFs dynamical core to improve the treatment of ...

  1. Modifications of the cell wall of yeasts grown on hexadecane...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Modifications of the cell wall of yeasts grown on hexadecane and under starvation conditions Title Modifications of the cell wall of yeasts grown on hexadecane and under starvation...

  2. Modifications and Optimization of the Organic Rankine Cycle ...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Modifications and Optimization of the Organic Rankine Cycle Modifications and Optimization of the Organic Rankine Cycle organicrankinecycle.pdf More Documents & Publications A...

  3. Controlled Covalent Modification of Epitaxial Single Layer Graphene...

    Office of Scientific and Technical Information (OSTI)

    Journal Article: Controlled Covalent Modification of Epitaxial Single Layer Graphene on ... Title: Controlled Covalent Modification of Epitaxial Single Layer Graphene on 6H-SiC ...

  4. Acquisition Guide Chapter 43.1, Contract Modifications

    Office of Energy Efficiency and Renewable Energy (EERE)

    This Policy Flash transmits the new Acquisition Guide Chapter 43.1, Contract Modifications, which provides a consistent approach for processing and executing modifications.

  5. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 11. CONTRACT ID <!;ODE 1 PAGE 1 OF 3 I PAGES 2. AMENDMENT/MODIFICATION NO. I 3. EFFECTIVE DATE 4. REQUISITION/PURCHASE IS. P1ROJECT NO. (If applicable) M528 See Block 16C REQ. NO. 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy National Nuclear Security Administration I Sandia Site Office (MS 0184) P.O. Box 5400 Albuquerque, NM 87185-5400 I 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county,

  6. Surface modification to prevent oxide scale spallation

    DOE Patents [OSTI]

    Stephens, Elizabeth V; Sun, Xin; Liu, Wenning; Stevenson, Jeffry W; Surdoval, Wayne; Khaleel, Mohammad A

    2013-07-16

    A surface modification to prevent oxide scale spallation is disclosed. The surface modification includes a ferritic stainless steel substrate having a modified surface. A cross-section of the modified surface exhibits a periodic morphology. The periodic morphology does not exceed a critical buckling length, which is equivalent to the length of a wave attribute observed in the cross section periodic morphology. The modified surface can be created using at least one of the following processes: shot peening, surface blasting and surface grinding. A coating can be applied to the modified surface.

  7. Development of an Improved Permeability Modification Simulator

    SciTech Connect (OSTI)

    Gao, H.W.; Elphnick, J.

    1999-03-09

    This report describes the development of an improved permeability modification simulator performed jointly by BDM Petroleum Technologies and Schlumberger Dowell under a cooperative research and development agreement (CRADA) with the US Department of Energy. The improved simulator was developed by modifying NIPER's PC-GEL permeability modification simulator to include a radial model, a thermal energy equation, a wellbore simulator, and a fully implicit time-stepping option. The temperature-dependent gelation kinetics of a delayed gel system (DGS) is also included in the simulator.

  8. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    National Nuclear Security Administration (NNSA)

    9 11. CONTRACT 10 CODE 1PAGE OF PAGES AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1 I 25 2. AMENDMENT/MODIFICATION NO. 3. EFFECTIVE DATE 4. REQUISITION/PURCHASE REQ . NO . 5 PROJECT NO. (If applicab/e) See Bl ock 1 6C 1 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE 105007 NNSA / Pantex Site Office 05007 NNSA/Pantex Site Office U.S. Department of Energy U.S. Department of Energy Nt SA/ Pantex S it e Offi ce NNSA/Pantex Site Office P.O. Box 30030 P . O . Box 30030

  9. Contract Modification Awarded for Legal Support

    Broader source: Energy.gov [DOE]

    Cincinnati - The Department of Energy today awarded a contract modification to A R Biddle & Associates, Inc. of Peachtree City, GA to add scope for the contractor to analyze contract claims that are appealed to the Civilian Board of Contract Appeals (CBCA).

  10. Restriction/modification polypeptides, polynucleotides, and methods

    DOE Patents [OSTI]

    Westpheling, Janet; Chung, DaeHwan; Huddleston, Jennifer; Farkas, Joel A

    2015-02-24

    The present invention relates to the discovery of a novel restriction/modification system in Caldicellulosiruptor bescii. The discovered restriction enzyme is a HaeIII-like restriction enzyme that possesses a thermophilic activity profile. The restriction/modification system also includes a methyltransferase, M.CbeI, that methylates at least one cytosine residue in the CbeI recognition sequence to m.sup.4C. Thus, the invention provides, in various aspects, isolated CbeI or M.CbeI polypeptides, or biologically active fragments thereof; isolated polynucleotides that encode the CbeI or M.CbeI polypeptides or biologically active fragments thereof, including expression vectors that include such polynucleotide sequences; methods of digesting DNA using a CbeI polypeptide; methods of treating a DNA molecule using a M.CbeI polypeptide; and methods of transforming a Caldicellulosiruptor cell.

  11. Effectiveness of decanter modifications on organic removal

    SciTech Connect (OSTI)

    Lambert, D.P.

    1992-08-20

    A series of runs were planned in the Precipitate Hydrolysis Experimental Facility (PHEF) at the Savannah River Plant to determine the effectiveness of equipment and process modifications on the PHEF decanter organic removal efficiency. Runs 54-59 were planned to test the effectiveness of spray recirculation, a new decanter, heated organic recirculation and aqueous drawoff on organic removal efficiency in the revised HAN flowsheet. Runs 60-63 were planned to provide a comparison of the original and new decanter designs on organic removal efficiency in the late wash flowsheet without organic recirculation. Operational problems were experienced in both the PHEF and IDMS pilot facilities because of the production of high boiling organics and the low organic removal efficiency of the PHEF decanters. To prevent these problems in the DWPF Salt and Chemical Cells, modifications were proposed to the decanter and flowsheet to maximize the organic removal efficiency and minimize production of high boiling organics.

  12. Modification of silica gel by organotitanium compounds

    SciTech Connect (OSTI)

    Khrustaleva, E.A.; Abramova, V.I.; Suvorov, A.L.; Fridman, L.I.

    1988-05-10

    The study of the modification of silica gels by various organotitanium compounds (OTC) is of interest in connection with their possible use as specific adsorbents, catalysts in the preparation of filled polymeric materials. The authors studied the modification of silica gel by OTC of different types in order to obtain reactive functional organic groups bound to titanium atoms on its surface. During treatment of silica gel with organotitanium compounds of different types in an organic solvent, these react chemically with the hydroxylic groups of silica gel to form Si-O-Ti groups on the surface, containing organic radicals bound to the titanium atom. In the case of coordinatively unsaturated OTC, increase in the time of interaction of the components on heating and excess OTC lead to partial splitting of the Si-O-Ti bonds, which is not observed for coordinatively saturated OTC.

  13. Regioselective chemical modification of monoclonal antibodies

    DOE Patents [OSTI]

    Ranadive, Girish; Rosenzweig, Howard S.; Epperly, Michael; Bloomer, William

    1993-01-01

    A method of selectively modifying an immunoglobulin having at least one Fab region and at least one Fc region, each region having an isoelectric point wherein said isoelectric point of the Fab fragment of said immunoglobulin is different than the isoelectric point of the Fc fragment of the immunoglobulin, said method comprising modification of the immunoglobulin at a pH between the respective isoelectric points of the Fab and Fc fragments of the immunoglobulin.

  14. MODIFICATIONS TO THE WIPP PANEL CLOSURE

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    29 Panel Closure ATTACHMENT 1 NMED COMMENTS ITEM 1 - MODIFICATIONS TO THE WIPP PANEL CLOSURE Page 2 of 29 Panel Closure 1-1: PMR Overview, Section 1, "Revision to the PCS Design" This section needs to explicitly explain which Attachment G1 Appendices are being deleted and which new appendices contain relevant information from old appendices. For example, Appendix B appears to include consolidated relevant information from the previous Appendices B through F; the new Appendix A replaces

  15. Regioselective chemical modification of monoclonal antibodies

    DOE Patents [OSTI]

    Ranadive, G.; Rozenzweig, H.S.; Epperly, M.; Bloomer, W.

    1993-05-04

    A method is presented of selectively modifying an immunoglobulin having at least one Fab region and at least one Fc region. Each region has an isoelectric point where the isoelectric point of the Fab fragment of the immunoglobulin is different from the isoelectric point of the Fc fragment of the immunoglobulin. The method comprises of a modification of the immunoglobulin at a pH between the respective isoelectric points of the Fab and Fc fragments of the immunoglobulin.

  16. Surface modification: advantages, techniques, and applications

    SciTech Connect (OSTI)

    Natesan, K.

    2000-03-01

    Adequate performance of materials at elevated temperatures is a potential problem in many systems within the chemical, petroleum, process, and power-generating industries. Degradation of materials occurs because of interaction between the structural material and the exposure environment. These interactions are generally undesired chemical reactions that can lead to accelerated wastage and alter the functional requirements and/or structural integrity of the materials. Therefore, material selection for high-temperature applications must be based not only on a material strength properties but also on resistance to the complex environments prevalent in the anticipated exposure environment. As plants become larger, the satisfactory performance and reliability of components play a greater role in plant availability and economics. However, system designers are becoming increasingly concerned with finding the least expensive material that will satisfactorily perform the design function for the desired service life. This present paper addresses the benefits of surface modification and identified several criteria for selection and application of modified surfaces in the power sector. A brief review is presented on potential methods for modification of surfaces, with the emphasis on coatings. In the final section of the paper, several examples address the requirements of different energy systems and surface modification avenues that have been applied to resolve the issues.

  17. Particle Distribution Modification by Low Amplitude Modes

    SciTech Connect (OSTI)

    White, R. B.; Gorelenkov, N.; Heidbrink, W. W.; Van Zeeland, M. A.

    2009-08-28

    Modification of a high energy particle distribution by a spectrum of low amplitude modes is investigated using a guiding center code. Only through resonance are modes effective in modifying the distribution. Diagnostics are used to illustrate the mode-particle interaction and to find which effects are relevant in producing significant resonance, including kinetic Poincare plots and plots showing those orbits with time averaged mode-particle energy transfer. Effects of pitch angle scattering and drag are studied, as well as plasma rotation and time dependence of the equilibrium and mode frequencies. A specific example of changes observed in a DIII-D deuterium beam distribution in the presence of low amplitude experimentally validated Toroidal Alfven (TAE) eigenmodes and Reversed Shear Alfven (RSAE) eigenmodes is examined in detail. Comparison with experimental data shows that multiple low amplitude modes can account for significant modification of high energy beam particle distributions. It is found that there is a stochastic threshold for beam profile modification, and that the experimental amplitudes are only slightly above this threshold.

  18. Biopolymer system for permeability modification in porous media

    SciTech Connect (OSTI)

    Stepp, A.K.; Bryant, R.S.; Llave, F.M.

    1995-12-31

    New technologies are needed to reduce the current high rate of well abandonment. Improved sweep efficiency, reservoir conformance, and permeability modification can have a significant impact on oil recovery processes. Microorganisms can be used to selectively plug high-permeability zones to improve sweep efficiency and impart conformance control. Studies of a promising microbial system for polymer production were conducted to evaluate reservoir conditions in which this system would be effective. Factors which can affect microbial growth and polymer production include salinity, pH, temperature, divalent ions, presence of residual oil, and rock matrix. Flask tests and coreflooding experiments were conducted to optimize and evaluate the effectiveness of this system. Nuclear magnetic resonance imaging (NMRI) was used to visualize microbial polymer production in porous media. Changes in fluid distribution within the pore system of the core were detected.

  19. Comment re DOE's NOI re continuation or modification of Price...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    NOI re continuation or modification of Price-Anderson Act Comment re DOE's NOI re continuation or modification of Price-Anderson Act Comments of Kerr-McGee Corporation to the ...

  20. DOE to Hold Public Information Meetings on Permit Modifications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Meetings On Permit Modifications CARLSBAD, N.M., May 8, 2001 - The public is invited to comment on two proposed modifications to the Hazardous Waste Facility Permit for the Waste Isolation Pilot Plant (WIPP). Submittal of the proposed modifications to the New Mexico Environment Department (NMED) by the U.S. Department of Energy (DOE) begins a formal review process that includes a 60-day public comment period and two separate public information meetings. The proposed modifications would support

  1. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    National Nuclear Security Administration (NNSA)

    1. CONTRACT ID <!;ODE 1 PAGE 1 OF 3 I PAGES 2. AMENDMENT/MODIFICATION NO. I 3. EFFECTIVE DATE 4. REQUISITION/PURCHASE IS. P1ROJECT NO. (If applicable) M528 See Block 16C REQ. NO. 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy National Nuclear Security Administration I Sandia Site Office (MS 0184) P.O. Box 5400 Albuquerque, NM 87185-5400 I 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, state, ZIP Code) 9A. AMENDMENT OF S<DLlCITATIONNO. I

  2. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    National Nuclear Security Administration (NNSA)

    Page 1 of 4 PAGES 2. AMENDMENT/MODIFICATION NO. M0538 3. EFFECTIVE DATE See Block 16C 4. REQUISITION/PURCHASE REQ. NO. 5. PROJECT NO. (If applicable) 6. ISSUED BY CODE U.S. Department of Energy National Nuclear Security Administration Sandia Site Office (MS 0184) P.O. Box 5400 Albuquerque, NM 87185-5400 7. ADMINISTERED BY (If other than Item 6) CODE 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, state, ZIP Code) Sandia Corporation P. O. Box 5800 Albuquerque, NM 87185 9A. AMENDMENT OF

  3. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    National Nuclear Security Administration (NNSA)

    , 1. CONTRACT ID CODE I PAGE OF PAGES 1 I 2 2. AMENDMENT/MODIFICATION NO. 3. EFFECTIVE DATE 4 . REQUISITION/PURCHASE REQ. NO. 15 PROJECT NO. (ff applicable) 0250 See Block 16C 6. ISSUED BY CODE 05003 7. ADMINISTERED BY (ff other than Item 6) coDE jo5003 NNSA/Los Alamos Site Off ice NNSA/Los Alamos Site Office U.S. Department of Energy U.S. Department of Energy NNSA/Los Alamos Site Office Los Alamos Site Off ice 3747 West Jemez Road 3747 West Jemez Road Los Alamos NM 87544 Los Alamos NM 87544 8.

  4. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    National Nuclear Security Administration (NNSA)

    1 OF30 PAGES 2. AMENDMENT/MODIFICATION NO. 13. EFFECTIVE DATE 4. REQUISITION/PURCHASE REQ. NO. I 5. PROJECT NO. (If applicable) 192 See Block 16 C G. ISSUED BY CODE 05003 7. ADMINISTERED BY (If other than Item 6) CODE 05003 NNSA/Los Alamos Site Office NNSA/Los Alamos Site Office U.S. Department of Energy U.S. Department of Energy Los Alamos Site Office Los Alamos Site Office 3747 West Jemez Road 3747 West Jemez Road Los Alamos, NM 87544 Los Alamos, NM 87544 8. NAME AND ADDRESS OF CONTRACTOR

  5. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    National Nuclear Security Administration (NNSA)

    CONTRACT ID CODE j PAGE OF PAGES 1 I 2 2 AMENDMENT/MODIFICATION NO 3. EFFECTIVE DATE 4 REQUISITION/PURCHASE REO NO. 15. PROJECT NO. (II applicable) 220 See Block 16C 6 ISSUED BY CODE 05003 7 ADMINISTERED BY (lfolherthan Item 6) CODE 105003 NNSA/Los Alamos Sile Office NNSA/Los Alamos Site Office u.s. Department of Energy u.s. Department of Energy Los Alamos Site Office Los Alamos Site Office 3747 West Jemez Road 3747 West Jemez Road Los Alamos Los Alamos NM 87544 NM 87544 8. NAME AND ADDRESS OF

  6. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    National Nuclear Security Administration (NNSA)

    AMENDMENT/MODIFICATION NO . 3. EFFECTIVE DATE 0232 See Block 16C 6. ISSUED BY CODE 05003 NNSA/Los Al amos Si t e Office U. S . Dep a rtme nt of Ene r gy Los Alamo s Sit e Off i ce 3747 We st Jemez Road Los Al a mos NM 87544 8. NAME AND ADDRESS OF CONTRACTOR (No. , street, county, State and ZIP Code) L A OS ALAMOS NAT I ONAL SECURI TY, ttn : STEVE K. SHOOK P.O . BOX 1663 , M S P222 L OS ALAMOS NM 875450001 CODE 175252894 LLC FACILITY CODE 11 . CONTRACT ID CODE I PAGE OF PAGES 1 I 2 4.

  7. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    National Nuclear Security Administration (NNSA)

    . CONTRACT 10 CODE PAGE 1 OF 2 PAGES 2. AMENDMENT/MODIFICATION NO. 13. EFFECTIVE DATE 4. REQUISITION/PURCHASE REQ. NO. 15. PROJECT NO. (If applicable) M058 See Block 16 C 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy National Nuclear Security Administration Manager, Los Alamos Site Office 3747 West Jemez Road, Building 1410, TA-3 Los Alamos, NM 87544 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, state, ZIP Code) 9A. AMENDMENT OF SOLICITATION

  8. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    I PAGlE 01 PAGES 1 2. AMENDMENT/MODIFICATION NO. 3. EFFECTIVE DATE 4. REQUISITION/PURCHASE REO. NO. I' PROJECT NO. (If applicable) 04 94 See Block 16C No PR 6. ISSUED BY CODE 00516 7. ADMINISTERED BY (If other than Item 6) CODE I u.s. Department of Energy ORNL Site Office P.O. Box 2008 Oak Ridge TN 37831 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, state and ZIP Code) ~ 9A. AMENDMENT OF SOLICITATION NO. 0 AK RIDGE ASSOCIATED UNIVERSITIES, INC. P.O. BOX 117 98. DATED (SEE ITEM 11) 0

  9. 2D MODIFICATION OF A CONTRACT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 2. AMENDMENT/MODIFICATION NO. M145 3. EFFECTIVE DATE (M/D/Y) See Block 16C 4. REQUISITION/PURCHASE REQ. NO. N/A 5. PROJECT NO. (If applicable) 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy Office of River Protection P. O. Box 450, MS H6-60 Richland, WA 99352 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP code) 9A. AMENDMENT OF SOLICITATION NO. Bechtel National, Inc. 2435 Stevens Center Place 9B. DATED (SEE ITEM 11) Richland,

  10. 2D MODIFICATION OF A CONTRACT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A150 3. EFFECTIVE DATE (M/D/Y) See Block 16C 4. REQUISITION/PURCHASE REQ. NO. 27-09RV14136.004 5. PROJECT NO. (If applicable) 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy Office of River Protection P. O. Box 450, MS H6-60 Richland, WA 99352 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP code) 9A. AMENDMENT OF SOLICITATION NO. Bechtel National, Inc. 50 Beale St. 9B. DATED (SEE ITEM 11) San Francisco, CA 94105 10A. MODIFICATION

  11. 2D MODIFICATION OF A CONTRACT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8 3. EFFECTIVE DATE (M/D/Y) See Block 16C 4. REQUISITION/PURCHASE REQ. NO. 04RV14136.006 5. PROJECT NO. (If applicable) 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy Office of River Protection P. O. Box 450, MS H6-60 Richland, WA 99352 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP code) 9A. AMENDMENT OF SOLICITATION NO. Bechtel National, Inc. 2435 Stevens Center Place 9B. DATED (SEE ITEM 11) Richland, WA 99352 10A. MODIFICATION

  12. 2D MODIFICATION OF A CONTRACT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    0 3. EFFECTIVE DATE (M/D/Y) See Block 16C 4. REQUISITION/PURCHASE REQ. NO. 04RV14136.006 5. PROJECT NO. (If applicable) 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy Office of River Protection P. O. Box 450, MS H6-60 Richland, WA 99352 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP code) 9A. AMENDMENT OF SOLICITATION NO. Bechtel National, Inc. 2435 Stevens Center Place 9B. DATED (SEE ITEM 11) Richland, WA 99352 10A. MODIFICATION

  13. 2D MODIFICATION OF A CONTRACT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 3. EFFECTIVE DATE (M/D/Y) See Block 16C 4. REQUISITION/PURCHASE REQ. NO. 04RV14136.006 5. PROJECT NO. (If applicable) 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy Office of River Protection P. O. Box 450, MS H6-60 Richland, WA 99352 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP code) 9A. AMENDMENT OF SOLICITATION NO. Bechtel National, Inc. 2435 Stevens Center Place 9B. DATED (SEE ITEM 11) Richland, WA 99352 10A. MODIFICATION

  14. 2D MODIFICATION OF A CONTRACT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 3. EFFECTIVE DATE (M/D/Y) See Block 16C 4. REQUISITION/PURCHASE REQ. NO. 04RV14136.009 5. PROJECT NO. (If applicable) 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy Office of River Protection P. O. Box 450, MS H6-60 Richland, WA 99352 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP code) 9A. AMENDMENT OF SOLICITATION NO. Bechtel National, Inc. 2435 Stevens Center Place 9B. DATED (SEE ITEM 11) Richland, WA 99352 10A. MODIFICATION

  15. 2D MODIFICATION OF A CONTRACT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4 3. EFFECTIVE DATE (M/D/Y) See Block 16C 4. REQUISITION/PURCHASE REQ. NO. 05RV14136.001 5. PROJECT NO. (If applicable) 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy Office of River Protection P. O. Box 450, MS H6-60 Richland, WA 99352 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP code) 9A. AMENDMENT OF SOLICITATION NO. Bechtel National, Inc. 2435 Stevens Center Place 9B. DATED (SEE ITEM 11) Richland, WA 99352 10A. MODIFICATION

  16. 2D MODIFICATION OF A CONTRACT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    5 3. EFFECTIVE DATE (M/D/Y) See Block 16C 4. REQUISITION/PURCHASE REQ. NO. 05RV14136.002 5. PROJECT NO. (If applicable) 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy Office of River Protection P. O. Box 450, MS H6-60 Richland, WA 99352 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP code) 9A. AMENDMENT OF SOLICITATION NO. Bechtel National, Inc. 2435 Stevens Center Place 9B. DATED (SEE ITEM 11) Richland, WA 99352 10A. MODIFICATION

  17. 2D MODIFICATION OF A CONTRACT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    6 3. EFFECTIVE DATE (M/D/Y) See Block 16C 4. REQUISITION/PURCHASE REQ. NO. 05RV14136.003 5. PROJECT NO. (If applicable) 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy Office of River Protection P. O. Box 450, MS H6-60 Richland, WA 99352 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP code) 9A. AMENDMENT OF SOLICITATION NO. Bechtel National, Inc. 2435 Stevens Center Place 9B. DATED (SEE ITEM 11) Richland, WA 99352 10A. MODIFICATION

  18. 2D MODIFICATION OF A CONTRACT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8 3. EFFECTIVE DATE (M/D/Y) See Block 16C 4. REQUISITION/PURCHASE REQ. NO. See Block 14 5. PROJECT NO. (If applicable) 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy Office of River Protection P. O. Box 450, MS H6-60 Richland, WA 99352 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP code) 9A. AMENDMENT OF SOLICITATION NO. Bechtel National, Inc. 2435 Stevens Center Place 9B. DATED (SEE ITEM 11) Richland, WA 99352 10A. MODIFICATION

  19. 2D MODIFICATION OF A CONTRACT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    17 2. AMENDMENT/MODIFICATION NO. A015 3. EFFECTIVE DATE (M/D/Y) 04/07/09 4. REQUISITION/PURCHASE REQ. NO. 5. PROJECT NO. (If applicable) 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy Office of River Protection P. O. Box 450, MS H6-60 Richland, WA 99352 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP code) 9A. AMENDMENT OF SOLICITATION NO. Washington River Protection Solutions LLC P.O. Box 73 9B. DATED (SEE ITEM 11) 720 Park Blvd

  20. 2D MODIFICATION OF A CONTRACT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    8 3. EFFECTIVE DATE (M/D/Y) See Block 16C 4. REQUISITION/PURCHASE REQ. NO. 03RV14136.005 5. PROJECT NO. (If applicable) 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy Office of River Protection P. O. Box 450, MS H6-60 Richland, WA 99352 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP code) 9A. AMENDMENT OF SOLICITATION NO. Bechtel National, Inc. 2435 Stevens Center 9B. DATED (SEE ITEM 11) Richland, WA 99352 10A. MODIFICATION OF

  1. 2D MODIFICATION OF A CONTRACT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    29 3. EFFECTIVE DATE (M/D/Y) See Block 16C 4. REQUISITION/PURCHASE REQ. NO. AN-NOPR 5. PROJECT NO. (If applicable) 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) COD U.S. Department of Energy Office of River Protection P. O. Box 450, MS H6-60 Richland, WA 99352 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP code) 9A. AMENDMENT OF SOLICITATION NO. Bechtel National, Inc. 2435 Stevens Center Place 9B. DATED (SEE ITEM 11) Richland, WA 99352 10A. MODIFICATION OF

  2. A study of microbial profile modification

    SciTech Connect (OSTI)

    Bae, J.H.; Lee, H.O.

    1995-12-31

    A microbial profile modification method using spores was investigated. A halotolerant, spore-forming, biopolymer-producing mesophile was used in Berea cores with a specifically formulated nutrient package to reduce the permeability of the rock. The degree of permeability reduction varied widely depending on the stimulation protocols used. The incubation period had a significant impact on permeability reduction, and there appeared to be an optimum incubation time for maximum permeability reduction. The reduction persisted for many PV of brine injection and appeared very stable. For our microbes used in this study, the permeability reduction was about the same when the NaCl concentration was above 2 wt% in the range from 0 wt% to 10 wt%.

  3. DOE to Hold Public Information Meetings On Proposed Permit Modification

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Meeting On Proposed Permit Modification CARLSBAD, N.M., January 31, 2001 - The public is invited to comment on a proposed modification to the Hazardous Waste Facility Permit for the Waste Isolation Pilot Plant (WIPP). Submittal of the proposed modification to the New Mexico Environment Department (NMED) by the U.S. Department of Energy (DOE) begins a formal review process that includes a 60-day public comment period and a public information meeting. In its request, DOE proposes alternative

  4. DOE to Hold Public Information Meetings on Requested Permit Modifications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Requested Permit Modifications CARLSBAD, N.M., March 15, 2001 -- The public is invited to comment on requested modifications to the Hazardous Waste Facility Permit for the Waste Isolation Pilot Plant (WIPP). Submittal of the proposed modification request to the New Mexico Environment Department (NMED) by the U.S. Department of Energy (DOE) begins a formal review process that includes a 60-day public comment period and public information meetings. In its submittal, DOE requests five permit

  5. Pnp gene modification for improved xylose utilization in Zymomonas

    DOE Patents [OSTI]

    Caimi, Perry G G; Qi, Min; Tao, Luan; Viitanen, Paul V; Yang, Jianjun

    2014-12-16

    The endogenous pnp gene encoding polynucleotide phosphorylase in the Zymomonas genome was identified as a target for modification to provide improved xylose utilizing cells for ethanol production. The cells are in addition genetically modified to have increased expression of ribose-5-phosphate isomerase (RPI) activity, as compared to cells without this genetic modification, and are not limited in xylose isomerase activity in the absence of the pnp modification.

  6. UniTech Task Order Modifications - DT0010421 - Hanford Site

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    UniTech Task Order Modifications - DT0010421 DOE-RL Contracts/Procurements RL Contracts & Procurements Home Prime Contracts Current Solicitations Other Sources DOE RL Contracting Officers DOE RL Contracting Officer Representatives UniTech Task Order Modifications - DT0010421 Email Email Page | Print Print Page | Text Increase Font Size Decrease Font Size 0006 The purpose of this modification is to provide $334,072.91 of incremental funding for the base period, for line item 0002 WRPS Laundry

  7. Education and Behavior Modification Resources | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Education and Behavior Modification Resources Education and Behavior Modification Resources Educating public employees of state and local governments and their citizens about modifying behavior in favor of conserving and following more energy-efficient practices represents an important element of a government's efforts to encourage a more energy efficient society and the benefits it provides to the public. Find education and behavior modification resources below. DOE Resources Energy Efficiency

  8. Tuning the Formations of Metal-Organic Frameworks by Modification...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Tuning the Formations of Metal-Organic Frameworks by Modification of Ratio of Reactant, ... (3D) framework structure with one-dimensional (1D) honeycomb channels. ...

  9. Modification of Lignin Content of Plant Cell Walls - Energy Innovation...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Biomass and Biofuels Biomass and Biofuels Find More Like This Return to Search Modification of Lignin Content of Plant Cell Walls Brookhaven National Laboratory Contact BNL About ...

  10. Microstructural Modification of a Cast Iron by Magnetic Field Processing

    SciTech Connect (OSTI)

    Kenik, Edward A; Ludtka, Gail Mackiewicz-; Ludtka, Gerard Michael; Wilgen, John B; Kisner, Roger A

    2010-01-01

    The current study deals with the microstructural modification of a nodular cast iron during solidification under the influence of high magnetic fields (up to 18 tesla).

  11. Surface Modification Agents Increase Safety, Security of Lithium...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Surface Modification Agents Increase Safety, Security of Lithium-Ion Batteries New Process to Modify the Surface of the Active Material Used in Lithium-Ion Batteries Argonne ...

  12. Surface Modification Agents for Lithium-Ion Batteries | Argonne...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Surface Modification Agents for Lithium-Ion Batteries Technology available for licensing: ... and security of batteries Substantially reduces power fade and potential for explosions. ...

  13. Modification of structure and magnetic anisotropy of epitaxial...

    Office of Scientific and Technical Information (OSTI)

    films by hydrogen reduction Citation Details In-Document Search Title: Modification of structure and magnetic anisotropy of epitaxial CoFeO films by hydrogen reduction ...

  14. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 11. CONTRACT...

    National Nuclear Security Administration (NNSA)

    ... Pollutant Discharge Elimination System 40 CFR 131 Water Quality Standards Modification No. ... 40 CFR 141 National Primary Drinking Water Regulations (2007) 40 CFR 143 National ...

  15. Modifications to the VV PHTS RELAP5 Model

    SciTech Connect (OSTI)

    Carbajo, Juan J

    2011-02-01

    Modifications and improvements to a previous RELAP5 model of the Vacuum Vessel Primary Heat Transfer System are described in this report. The modifications were new pump models, a new steam pressurizer, new coolant water control systems, additional pipe structures, and reduction of the pulse power to 6 MW.

  16. Crystal structure of laser-induced subsurface modifications in Si

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Verburg, P. C.; Smillie, L. A.; Römer, G. R. B. E.; Haberl, B.; Bradby, J. E.; Williams, J. S.; Huis in ’t Veld, A. J.

    2015-06-04

    Laser-induced subsurface modification of dielectric materials is a well-known technology. Applications include the production of optical components and selective etching. In addition to dielectric materials, the subsurface modification technology can be applied to silicon, by employing near to mid-infrared radiation. An application of subsurface modifications in silicon is laser-induced subsurface separation, which is a method to separate wafers into individual dies. Other applications for which proofs of concept exist are the formation of waveguides and resistivity tuning. However, limited knowledge is available about the crystal structure of subsurface modifications in silicon. In this paper, we investigate the geometry and crystalmore » structure of laser-induced subsurface modifications in monocrystalline silicon wafers. Finally, in addition to the generation of lattice defects, we found that transformations to amorphous silicon and Si-iii/Si-xii occur as a result of the laser irradiation.« less

  17. Crystal structure of laser-induced subsurface modifications in Si

    SciTech Connect (OSTI)

    Verburg, P. C.; Smillie, L. A.; Römer, G. R. B. E.; Haberl, B.; Bradby, J. E.; Williams, J. S.; Huis in ’t Veld, A. J.

    2015-06-04

    Laser-induced subsurface modification of dielectric materials is a well-known technology. Applications include the production of optical components and selective etching. In addition to dielectric materials, the subsurface modification technology can be applied to silicon, by employing near to mid-infrared radiation. An application of subsurface modifications in silicon is laser-induced subsurface separation, which is a method to separate wafers into individual dies. Other applications for which proofs of concept exist are the formation of waveguides and resistivity tuning. However, limited knowledge is available about the crystal structure of subsurface modifications in silicon. In this paper, we investigate the geometry and crystal structure of laser-induced subsurface modifications in monocrystalline silicon wafers. Finally, in addition to the generation of lattice defects, we found that transformations to amorphous silicon and Si-iii/Si-xii occur as a result of the laser irradiation.

  18. Permeability Modification Using a Reactive Alkaline-Soluble Biopolymer

    SciTech Connect (OSTI)

    Snadra L. Fox; X. Xie; K. D. Schaller; E. P. Robertson; G. A. Bala

    2003-10-01

    Polymer injection has been used in reservoirs to alleviate contrasting permeability zones. Current technology relies on the use of cross-linking agents to initiate gelation. The use of biological polymers are advantageous in that they can block high permeability areas, are environmentally friendly, and have potential to form reversible gels without the use of hazardous cross-linkers. Recent efforts at the Idaho National Engineering and Environmental Laboratory (INEEL) have produced a reactive alkaline-soluble biopolymer from Agrobacterium sp. ATCC no. 31749 that gels upon decreasing the pH of the polymeric solution. The focus of this study was to determine the impact an alkaline-soluble biopolymer can have on sandstone permeability. Permeability modification was investigated by injecting solubilized biopolymer into Berea sandstone cores and defining the contribution of pH, salt, temperature, and Schuricht crude oil on biopolymer gelation. The biopolymer was soluble in KOH at a pH greater than 11.4 and gelled when the pH dropped below 10.8. The Berea sandstone core buffered the biopolymer solution, decreasing the pH sufficiently to form a gel, which subsequently decreased the permeability. The effluent pH of the control cores injected with 0.01 {und M} KOH (pH 12.0) and 0.10{und M} KOH (pH 13.0) decreased to 10.6 and 12.7, respectively. The permeability of the sandstone core injected with biopolymer was decreased to greater than 95% of the original permeability at 25 C in the presence of 2% NaCl, and Schuricht crude oil; however, the permeability increased when the temperature of the core was increased to 60 C. Residual resistance factors as high as 792 were seen in Berea cores treated with biopolymer. The buffering capacity of sandstone has been demonstrated to reduce the pH of a biopolymer solution sufficiently to cause the polymer to form a stable in-situ gel. This finding could potentially lead to alternate technology for permeability modification, thus

  19. Technological modifications in the nitrogen oxides tradable permit program

    SciTech Connect (OSTI)

    Linn, J.

    2008-07-01

    Tradable permit programs allow firms greater flexibility in reducing emissions than command-and-control regulations and encourage firms to use low cost abatement options, including small-scale modifications to capital equipment. This paper shows that firms have extensively modified capital equipment in the Nitrogen Oxides Budget Trading Program, which covers power plants in the eastern United States. The empirical strategy uses geographic and temporal features of the program to estimate counterfactual emissions, finding that modifications have reduced emission rates by approximately 10-15 percent. The modifications would not have occurred under command-and-control regulation and have reduced regulatory costs.

  20. Selective posttranslational modification of phage-displayed polypeptides

    DOE Patents [OSTI]

    Tsao, Meng-Lin; Tian, Feng; Schultz, Peter

    2013-02-05

    The invention relates to posttranslational modification of phage-displayed polypeptides. These displayed polypeptides comprise at least one unnatural amino acid, e.g., an aryl-azide amino acid such as p-azido-L-phenylalanine, or an alkynyl-amino acid such as para-propargyloxyphenylalanine, which are incorporated into the phage-displayed fusion polypeptide at a selected position by using an in vivo orthogonal translation system comprising a suitable orthogonal aminoacyl-tRNA synthetase and a suitable orthogonal tRNA species. These unnatural amino acids advantageously provide targets for posttranslational modifications such as azide-alkyne [3+2]cycloaddition reactions and Staudinger modifications.

  1. Selective posttranslational modification of phage-displayed polypeptides

    DOE Patents [OSTI]

    Tsao, Meng-Lin; Tian, Feng; Schultz, Peter

    2013-11-19

    The invention relates to posttranslational modification of phage-displayed polypeptides. These displayed polypeptides comprise at least one unnatural amino acid, e.g., an aryl-azide amino acid such as p-azido-L-phenylalanine, or an alkynyl-amino acid such as para-propargyloxyphenylalanine, which are incorporated into the phage-displayed fusion polypeptide at a selected position by using an in vivo orthogonal translation system comprising a suitable orthogonal aminoacyl-tRNA synthetase and a suitable orthogonal tRNA species. These unnatural amino acids advantageously provide targets for posttranslational modifications such as azide-alkyne [3+2] cycloaddition reactions and Staudinger modifications.

  2. OT SPECIFIED I OTHER AMENDMENT OF SOLICITATI ON/MODIFICATION...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MODIFIC ATION OF CO NTRACTIORD ER NO A DE-AC05 - 060R 23 100 l OB DATED (SEE ITEM 13) 12 21 2005 11 . THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITA TI ONS L the above numbered...

  3. TRAC Code Modifications Made for APT Blanket Safety Analyses

    SciTech Connect (OSTI)

    Hamm, L.L.

    1998-10-07

    This report provides documentation of the necessary source code modifications made to the TRAC-PF1/MOD2 code version 5.4.28a developed at Los Alamos National Laboratory.

  4. DOE Awards Task Order Modification for Support Services to Office...

    Office of Environmental Management (EM)

    Cincinnati - The Department of Energy (DOE) today awarded a modification to Task Order DE-DT0005235 to J.G. Management Systems, Inc. of Grand Junction, CO for administrative and ...

  5. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1. CONTRACT...

    National Nuclear Security Administration (NNSA)

    Alamos, NM 87544 10A. MODIFICATION OF CONTRACTORDER NO. DE-AC52-06NA25396 CODE ... OF CONTRACTSORDERS; IT MODIFIES THE CONTRACTORDER NO. AS DESCRIBED IN ITEM 14. A. ...

  6. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 11. CONTRACT...

    National Nuclear Security Administration (NNSA)

    (SEE ITEM 11) X 10A MODIFICATION OF CONTRACTORDER NO. DE-AC52-06NA25396 10B. DATED ... OF CONTRACTSORDERS. IT MODIFIES THE CONTRACTORDER NO. AS DESCRIBED IN ITEM 14. A ...

  7. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1. CONTRACT...

    National Nuclear Security Administration (NNSA)

    MODIFICATION OF Los Alamos, NM 87544 CONTRACTORDER NO. DE-AC52-06NA25396 CODE ... OF CONTRACTSORDERS; IT MODIFIES THE CONTRACTORDER NO. AS DESCRIBED IN ITEM 14. A. ...

  8. Modifications and Optimization of the Organic Rankine Cycle | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Modifications and Optimization of the Organic Rankine Cycle Modifications and Optimization of the Organic Rankine Cycle organic_rankine_cycle.pdf (580.43 KB) More Documents & Publications A Quantum Leap for Heavy-Duty Truck Engine Efficiency - Hybrid Power System of Diesel and WHR-ORC Engines High Efficiency Engine Systems Development and Evaluation Advanced Natural Gas Reciprocating Engines (ARES) - Presentation by Caterpillar, Inc., June 2011

  9. DOE to Hold Public Information Meetings On Proposed Permit Modification

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    December 14, 2000 - The public is invited to comment on a proposed modification to the Hazardous Waste Facility Permit for the Waste Isolation Pilot Plant (WIPP). Submittal of the proposed modification to the New Mexico Environment Department (NMED) by the U.S. Department of Energy (DOE) begins a formal review process that includes a 60-day public comment period and two separate public information meetings next month. In its request, DOE proposes to modify requirements for Drum Age Criteria

  10. DOE to Hold Public Information Meetings On Proposed Permit Modification

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    July 26, 2000 - The public is invited to comment on a proposed modification to the Hazardous Waste Facility Permit for the Waste Isolation Pilot Plant (WIPP). Submittal of the proposed modification to the New Mexico Environment Department (NMED) by the U.S. Department of Energy (DOE) begins a formal review process that includes a 60-day public comment period and two separate public information meetings. In its request, DOE proposes to increase the aboveground storage capacity at WIPP by 25

  11. Design review report for modifications to RMCS safety class equipment

    SciTech Connect (OSTI)

    Corbett, J.E.

    1997-05-30

    This report documents the completion of the formal design review for modifications to the Rotary Mode Core Sampling (RMCS) safety class equipment. These modifications are intended to support core sampling operations in waste tanks requiring flammable gas controls. The objective of this review was to approve the Engineering Change Notices affecting safety class equipment used in the RMCS system. The conclusion reached by the review committee was that these changes are acceptable.

  12. Geothermal Economics Calculator (GEC) - additional modifications to final

    Office of Scientific and Technical Information (OSTI)

    report as per GTP's request. (Technical Report) | SciTech Connect Geothermal Economics Calculator (GEC) - additional modifications to final report as per GTP's request. Citation Details In-Document Search Title: Geothermal Economics Calculator (GEC) - additional modifications to final report as per GTP's request. This report will discuss the methods and the results from economic impact analysis applied to the development of Enhanced Geothermal Systems (EGS), conventional hydrothermal, low

  13. Procedure for developing biological input for the design, location, or modification of water-intake structures

    SciTech Connect (OSTI)

    Neitzel, D.A.; McKenzie, D.H.

    1981-12-01

    To minimize adverse impact on aquatic ecosystems resulting from the operation of water intake structures, design engineers must have relevant information on the behavior, physiology and ecology of local fish and shellfish. Identification of stimulus/response relationships and the environmental factors that influence them is the first step in incorporating biological information in the design, location or modification of water intake structures. A procedure is presented in this document for providing biological input to engineers who are designing, locating or modifying a water intake structure. The authors discuss sources of stimuli at water intakes, historical approaches in assessing potential/actual impact and review biological information needed for intake design.

  14. Effects of arsenic on modification of promyelocytic leukemia (PML): PML responds to low levels of arsenite

    SciTech Connect (OSTI)

    Hirano, Seishiro; Watanabe, Takayuki; Kobayashi, Yayoi

    2013-12-15

    Inorganic arsenite (iAs{sup 3+}) is a two-edged sword. iAs{sup 3+} is a well-known human carcinogen; nevertheless, it has been used as a therapeutic drug for acute promyelocytic leukemia (APL), which is caused by a fusion protein comprising retinoic acid receptor-? and promyelocytic leukemia (PML). PML, a nuclear transcription factor, has a RING finger domain with densely positioned cysteine residues. To examine PML-modulated cellular responses to iAs{sup 3+}, CHO-K1 and HEK293 cells were each used to establish cell lines that expressed ectopic human PML. Overexpression of PML increased susceptibility to iAs{sup 3+} in CHO-K1 cells, but not in HEK293 cells. Exposure of PML-transfected cells to iAs{sup 3+} caused PML to change from a soluble form to less soluble forms, and this modification of PML was observable even with just 0.1 ?M iAs{sup 3+} (7.5 ppb). Western blot and immunofluorescent microscopic analyses revealed that the biochemical changes of PML were caused at least in part by conjugation with small ubiquitin-like modifier proteins (SUMOylation). A luciferase reporter gene was used to investigate whether modification of PML was caused by oxidative stress or activation of antioxidant response element (ARE) in CHO-K1 cells. Modification of PML protein occurred faster than activation of the ARE in response to iAs{sup 3+}, suggesting that PML was not modified as a consequence of oxidative stress-induced ARE activation. - Highlights: PML was found in nuclear microspecles in response to arsenite. Arsenite triggers SUMOylation of PML. Arsenite modifies PML at as low as 0.1 ?M. Modification of PML is not caused by ARE activation.

  15. Modification of chemical and physical factors in steamflood to increase heavy oil recovery

    SciTech Connect (OSTI)

    Yortsos, Y.C.

    1990-02-01

    This report summarizes research progress made during the period October 1, 1988--September 30, 1989. We report advances in the following general areas: (1) chemical-steam simulation model, (2) vapor-liquid flow in porous media, (3) foam flow in porous media, (4) caustic flooding at elevated temperatures, and (5) reservoir heterogeneity. Additional efforts have been devoted in the last quarter of the past year in upgrading and debugging the simulator. New features were added in three-phase relative permeabilities, the vertical equilibrium and the phase behavior subroutines. 123 refs., 79 figs., 2 tabs.

  16. Evaluation of proposed panel closure modifications at WIPP

    SciTech Connect (OSTI)

    Allen, Lawrence E.; Silva, Matthew K.; Channell, James K.; Abel, John F.; Morgan, Dudley R.

    2001-12-31

    A key component in the design of the WIPP repository is the installation of concrete structures as panel seals in the intake and exhaust drifts after a panel has been filled with waste containers. As noted in the EPA final rule, the panel seal closure system is intended to block brine flow between the waste panels at the WIPP. On April 17, 2001, the DOE proposed seven modifications to the EPA concerning the design of the panel closure system. EPA approval of these modifications is necessary since the details of the panel design are specified in EPA’s final rule as a condition for WIPP certification. However, the EPA has not determined whether a rulemaking would be required for these proposed design modifications. On September 4, 2001, the DOE withdrew the request, noting that it would be resubmitted on a future date. The Environmental Evaluation Group (EEG) contracted with two engineers, Dr. John Abel and Dr. Rusty Morgan, to evaluate the proposed modifications. The EEG has accepted the conclusions and recommendations from these two experts: 1) replacement of Salado Mass Concrete with a generic salt-based concrete; 2) replacement of the explosion wall with a construction wall; 3) replacement of freshwater grouting with salt-based grouting; 4) option to allow surface or underground mixing; and 5) option to allow up to one year for completion of closure. The proposed modification to allow local carbonate river rock as aggregate is acceptable pending demonstration that no problems will exist in the resulting concrete. The proposed modification to give the contractor discretion in removal of steel forms is not supported. Instead, several recommendations are made to specifically reduce the number of forms left, thereby reducing potential migration pathways.

  17. AME:NDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    National Nuclear Security Administration (NNSA)

    AME:NDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1. CONTRACT 10 CODE PAGE 1 OF 224 PAGES 2. AMENDMENT/MODIFICATION NO. M202 3. EFFECTIVE DATE October 1, 2003 4. REQUISITION/PURCHASE REQ. NO. 5. PROJECT NO. (If applicable) 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.s. Department of Energy N.itional Nuclear Security Administration Sandia Site Office Mail Stop 0184 P.O. Box 5400 AlbuauerQue, NM 87185-5400 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, state, ZIP

  18. BlueGene/L Specific Modifications to DynInst

    Energy Science and Technology Software Center (OSTI)

    2007-07-02

    DynInst is a dynamic instrumentation library that allows for the modification of running code. This runtime code patching ability allows an application to be modified without requiring the code to be recompiled or relinked. These properties make dynamic instrumentation an attractive method for gathering performance data, debugging an application, or steering an application's execution. This release covers modifications that were made to port this software to the BlueGene/L architecture. It also covers some additional filesmore » that were created for this port.« less

  19. L AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    National Nuclear Security Administration (NNSA)

    L _ AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 2. AMENDMENT/MODIFICATION NO. 3. EFFECTIVE DATE 25 7 See Block 16C 6 . 1SSUED BY CODE 0500 8 NNSA/ Oa kridge Site Office u.s. De pa rtment of Energ y NNSA/ Y-12 S it e Offic e P. O. Box 2 05 0 Bu ilding 97 0 4- 2 Oak Ridge TN 37831 8 . NAME AND ADDRESS OF CONTRACTOR (No., street, county. state and ZIP Code) ABCOCK & WILCOX TECHNICAL B A t t n: W ILLIE J. W I LSON PO BOX 2009 SERVICES Y- 12 , LLC ,1 . CONTRACT ID CODE I PAGE OF PAGES 1 I

  20. X AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    National Nuclear Security Administration (NNSA)

    ? X AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 11. CONTRACT 10 CODE 1 PAGE 1 of7 2. AMENDMENT/MODIFICATION NO. 13. EFFECTIVE DATE M197 See Block 16C 6. ISSUED BY CODE U.S. Department of Energy National Nuclear Security Administration P.O. Box 2050 Oak Ridge, TN 37831 AC PAGES 4. REQUISITION/PURCHASE I5. PROJECT NO. (If applicable) REQ. NO. NOPR 7. ADMINISTERED BY (If other than Item 6) CODE 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, state, ZIP Code) Babcock & Wilcox

  1. Surface modification of ultra thin PES-zeolite using thermal annealing to increase flux and rejection of produced water treatment

    SciTech Connect (OSTI)

    Kusworo, T. D. Widayat,; Pradini, A. W.; Armeli, Y. P.

    2015-12-29

    Membrane technology is an alternative of water treatment based on filtration that is being developed. Surface Modification using heat treatment has been investigated to improve the performance of ultra thin PES-Zeolite nanocomposite membrane for produced water treatment from Pertamina Balongan. Two types of membranes with surface modification and without modification were prepared to study the effect of surface modification on its permeation properties. Asymmetric ultra thin PES-Zeolite nanocomposite membrane for produced water treatment was casted using the dry/wet phase inversion technique from dope solutions containing polyethersulfone, N-methyl-2-pyrrolidone (NMP) as a solvent and zeolite as a filler. Experimental results showed that the heat treatment at near glass transition temperature was increase the rejection of COD, Turbidity and ion Ca{sup 2+}. The better adherence of zeolite particles in the polymer matrix combined with formation of charge transfer complexes (CTCs) and cross-linking might be the main factors to enhance the percent of rejection. Field emission scanning electron microscopy (FESEM) micrographs showed that the selective layer and the substructure of PES-zeolite membrane became denser and more compact after the heat treatment. The FESEM micrographs also showed that the heat treatment was increased the adherence of zeolite particle and polymer. Membranes treated at 180 °C for 15 seconds indicated increase the rejection and small decrease in flux for produced water treatment.

  2. ELECTROMOTIVE FORCE, EMF (CELLS) (Miscellaneous) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Publication Date: 1998-09-16 OSTI Identifier: 760971 Report Number(s): BNL--65847; KC030101 R&D Project: AS002CSD; KC030101; TRN: AH200035%%46 DOE Contract Number: AC02-98CH10886 ...

  3. Simple modification of Compton polarimeter to redirect synchrotron radiation

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Benesch, Jay F.; Franklin, Gregg B.; Quinn, Brian P.; Paschke, Kent D.

    2015-11-30

    Synchrotron radiation produced as an electron beam passes through a bending magnet is a significant source of background in many experiments. Using modeling, we show that simple modifications of the magnet geometry can reduce this background by orders of magnitude in some circumstances. Specifically, we examine possible modifications of the four dipole magnets used in Jefferson Labs Hall A Compton polarimeter chicane. This Compton polarimeter has been a crucial part of experiments with polarized beams and the next generation of experiments will utilize increased beam energies, up to 11 GeV, requiring a corresponding increase in Compton dipole field to 1.5moreT. In consequence, the synchrotron radiation (SR) from the dipole chicane will be greatly increased. Three possible modifications of the chicane dipoles are studied; each design moves about 2% of the integrated bending field to provide a gentle bend in critical regions along the beam trajectory which, in turn, greatly reduces the synchrotron radiation within the acceptance of the Compton polarimeter photon detector. Each of the modifications studied also softens the SR energy spectrum at the detector sufficiently to allow shielding with 5 mm of lead. Simulations show that these designs are each capable of reducing the background signal due to SR by three orders of magnitude. The three designs considered vary in their need for vacuum vessel changes and in their effectiveness.less

  4. Ethanol fuel modification for highway vehicle use. Final report

    SciTech Connect (OSTI)

    Not Available

    1980-01-01

    A number of problems that might occur if ethanol were used as a blending stock or replacement for gasoline in present cars are identified and characterized as to the probability of occurrence. The severity of their consequences is contrasted to those found with methanol in a previous contract study. Possibilities for correcting several problems are reported. Some problems are responsive to fuel modifications but others require or are better dealt with by modification of vehicles and the bulk fuel distribution system. In general, problems with ethanol in blends with gasoline were found to be less severe than those with methanol. Phase separation on exposure to water appears to be the major problem with ethanol/gasoline blends. Another potentially serious problem with blends is the illict recovery of ethanol for beverage usage, or bootlegging, which might be discouraged by the use of select denaturants. Ethanol blends have somewhat greater tendency to vapor lock than base gasoline but less than methanol blends. Gasoline engines would require modification to operate on fuels consisting mostly of ethanol. If such modifications were made, cold starting would still be a major problem, more difficult with ethanol than methanol. Startability can be provided by adding gasoline or light hydrocarbons. Addition of gasoline also reduces the explosibility of ethanol vapor and furthermore acts as denaturant.

  5. Douglas Factors

    Broader source: Energy.gov [DOE]

    The Merit Systems Protection Board in its landmark decision, Douglas vs. Veterans Administration, 5 MSPR 280, established criteria that supervisors must consider in determining an appropriate penalty to impose for an act of employee misconduct. These twelve factors are commonly referred to as “Douglas Factors” and have been incorporated into the Federal Aviation Administration (FAA) Personnel Management System and various FAA Labor Agreements.

  6. Modifications and Optimization of the Organic Rankine Cycle

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Modifications and Optimization of the Organic Rankine Cycle Improved Recovery of Waste Heat in Industrial Processes Introduction Waste heat from turbines and engines used in industrial ap- plications along with waste heat from industrial processes are exceptionally abundant sources of energy. If even a fraction of this waste heat could be economically converted to useful elec- tricity, it would have a tangible and very positive impact on the economic health, energy consumption, and carbon

  7. Improving experimental phases for strong reflections prior to density modification

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Uervirojnangkoorn, Monarin; Hilgenfeld, Rolf; Terwilliger, Thomas C.; Read, Randy J.

    2013-09-20

    Experimental phasing of diffraction data from macromolecular crystals involves deriving phase probability distributions. These distributions are often bimodal, making their weighted average, the centroid phase, improbable, so that electron-density maps computed using centroid phases are often non-interpretable. Density modification brings in information about the characteristics of electron density in protein crystals. In successful cases, this allows a choice between the modes in the phase probability distributions, and the maps can cross the borderline between non-interpretable and interpretable. Based on the suggestions by Vekhter [Vekhter (2005), Acta Cryst. D61, 899–902], the impact of identifying optimized phases for a small number ofmore » strong reflections prior to the density-modification process was investigated while using the centroid phase as a starting point for the remaining reflections. A genetic algorithm was developed that optimizes the quality of such phases using the skewness of the density map as a target function. Phases optimized in this way are then used in density modification. In most of the tests, the resulting maps were of higher quality than maps generated from the original centroid phases. In one of the test cases, the new method sufficiently improved a marginal set of experimental SAD phases to enable successful map interpretation. Lastly, a computer program,SISA, has been developed to apply this method for phase improvement in macromolecular crystallography.« less

  8. Large voltage-induced modification of spin-orbit torques in Pt/Co/GdOx

    SciTech Connect (OSTI)

    Emori, Satoru Bauer, Uwe; Woo, Seonghoon; Beach, Geoffrey S. D.

    2014-12-01

    We report on large modifications of current-induced spin-orbit torques in a gated Pt/Co/Gd-oxide microstrip due to voltage-driven O{sup 2−} migration. The Slonczewski-like and field-like torques are quantified using a low-frequency harmonic technique based on the polar magneto-optical Kerr effect. Voltage-induced oxidation of Co enhances the Slonczewski-like torque by as much as an order of magnitude and simultaneously reduces the anisotropy energy barrier by a factor of ∼5. Such magneto-ionic tuning of interfacial spin-orbit effects may significantly enhance the efficiency of magnetization switching and provide additional degrees of freedom in spintronic devices.

  9. Contract DE-AC02-07CH11358 Modifications Language Changes

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AC02-07CH11358 Modifications Language Changes Modification 183 October 23, 2015 Part I, Section H - Special Contract Requirements (replace Mod 171) Part II, Section I - Contract...

  10. File:S-38-Well-Construction-and-Modification-Permit.pdf | Open...

    Open Energy Info (EERE)

    S-38-Well-Construction-and-Modification-Permit.pdf Jump to: navigation, search File File history File usage File:S-38-Well-Construction-and-Modification-Permit.pdf Size of this...

  11. Brine pH Modification Scale Control Technology. 2. A Review.pdf...

    Open Energy Info (EERE)

    Brine pH Modification Scale Control Technology. 2. A Review.pdf Jump to: navigation, search OpenEI Reference LibraryAdd to library Journal Article: Brine pH Modification Scale...

  12. Contract No. DE-AC27-OIRV14136 Modification No. A185 SF-30 Continuation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    OIRV14136 Modification No. A185 SF-30 Continuation Purpose of Modification: The purpose of contract modification A185 is to update Section B, Services & Prices/Costs. The subject modification incorporates funding for Inter-Entity Work Order (IEWO) M05RV00028, Amendment No. 6. The total funded amount is increased by $351,000.00, from $480,201 .00 to $831,201.00. Description of Modification: Section B - Supplies or Services and Prices/Costs 1 . Update Section B, Supplies or Services and

  13. Advanced Design Mixer Pump Tank 18 Design Modifications Summary Report

    SciTech Connect (OSTI)

    Adkins, B.J.

    2002-12-03

    The Westinghouse Savannah River Company (WSRC) is preparing to retrieve high level waste (HLW) from Tank 18 in early FY03 to provide feed for the Defense Waste Processing Facility (DWPF) and to support tank closure in FY04. As part of the Tank 18 project, WSRC will install a single Advanced Design Mixer Pump (ADMP) in the center riser of Tank 18 to mobilize, suspend, and mix radioactive sludge in preparation for transfer to Tank 7. The use of a single ADMP is a change to the current baseline of four (4) standard slurry pumps used during previous waste retrieval campaigns. The ADMP was originally conceived by Hanford and supported by SRS to provide a more reliable and maintainable mixer pump for use throughout the DOE complex. The ADMP underwent an extensive test program at SRS between 1998 and 2002 to assess reliability and hydraulic performance. The ADMP ran for approximately 4,200 hours over the four-year period. A detailed tear down and inspection of the pump following the 4,2 00-hour run revealed that the gas mechanical seals and anti-friction bearings would need to be refurbished/replaced prior to deployment in Tank 18. Design modifications were also needed to meet current Authorization Basis safety requirements. This report documents the modifications made to the ADMP in support of Tank 18 deployment. This report meets the requirements of Tanks Focus Area (TFA) Milestone 3591.4-1, ''Issue Report on Modifications Made to the ADMP,'' contained in Technical Task Plan (TTP) SR16WT51, ''WSRC Retrieval and Closure.''

  14. Improved LWR Cladding Performance by EPD Surface Modification Technique

    SciTech Connect (OSTI)

    Corradini, Michael; Sridharan, Kumar

    2012-11-26

    This project will utilize the electro-phoretic deposition technique (EPD) in conjunction with nanofluids to deposit oxide coatings on prototypic zirconium alloy cladding surfaces. After demonstrating that this surface modification is reproducible and robust, the team will subject the modified surface to boiling and corrosion tests to characterize the improved nucleate boiling behavior and superior corrosion performance. The scope of work consists of the following three tasks: The first task will employ the EPD surface modification technique to coat the surface of a prototypic set of zirconium alloy cladding tube materials (e.g. Zircaloy and advanced alloys such as M5) with a micron-thick layer of zirconium oxide nanoparticles. The team will characterize the modified surface for uniformity using optical microscopy and scanning-electron microscopy, and for robustness using standard hardness measurements. After zirconium alloy cladding samples have been prepared and characterized using the EPD technique, the team will begin a set of boiling experiments to measure the heat transfer coefficient and critical heat flux (CHF) limit for each prepared sample and its control sample. This work will provide a relative comparison of the heat transfer performance for each alloy and the surface modification technique employed. As the boiling heat transfer experiments begin, the team will also begin corrosion tests for these zirconium alloy samples using a water corrosion test loop that can mimic light water reactor (LWR) operational environments. They will perform extended corrosion tests on the surface-modified zirconium alloy samples and control samples to examine the robustness of the modified surface, as well as the effect on surface oxidation

  15. Apparatus and method for electrochemical modification of liquids

    DOE Patents [OSTI]

    James, Patrick I

    2015-04-21

    An apparatus for electrochemical modification of liquid streams employing an electrolytic cell which includes an anode compartment defined by an anode structure where oxidation is effected, containing a liquid electrolyte anolyte, and a cathode compartment defined by a cathode structure where reduction is effected containing a liquid electrolyte catholyte. In addition, the electrolytic cell includes at least one additional compartment arranged at least partially between the anode compartment and the cathode compartment and separated from the anode compartment and the cathode compartment by a separator structure arranged to supports ionic conduction of current between the anode structure and the cathode structure.

  16. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT I~' CONTRACT

    National Nuclear Security Administration (NNSA)

    I~' CONTRACT ID CODE IPAGE OF PAGES DE-NR0000031 . 1 I 1 2. AMENDMENT/MODIFICATION NO. 3. EFFECTIVE DATE 4. REQUISITION/PURCHASE REQ. NO. I 5. PROJECT NO. (If applicable) 003 Same as Block 16G . N~ 6. ISSUED BV CODE 7. ADMINISTERED BV (If other than Item 6) Code I U.S. Department of Energy Pittsburgh Naval Reactors Office P.O. Box 109 West Mifflin, PA 15122-0109 8. NAME AND ADDRESS OF CONTRACTOR (No. street, county, State and ZIP Code) (*...) 9.A. AMENDMENT OF SOLICITATION NO. Bechtel Marine

  17. Generator modification and characterization of the Ranchero explosive generator

    SciTech Connect (OSTI)

    Oona, Henn; Goforth, James H; Tasker, Douglas G

    2008-01-01

    Magnetic Flux Compression Generators (FCG) have been used as a power source for plasma and metal liner implosions over several decades. We have used the cost effective Ranchero generator to study hydrodynamic effects and instability growth in aluminium liners. Sometimes it is useful to tailor the shape of the current and voltage pulse. Modifications to the geometry can facilitate this task. Changes in the geometrical features of the generator can be used to allow the desired current waveform to be delivered to the load region.

  18. Protein Modifications as Potential Biomarkers in Breast Cancer

    SciTech Connect (OSTI)

    Jin, Hongjun; Zangar, Richard C.

    2009-11-30

    A variety of post-translational protein modifications (PTMs) are known to be altered as a result of cancer development. Thus, these PTMs are potentially useful biomarkers for breast cancer. Mass spectrometry, antibody microarrays and immunohistochemistry techniques have shown promise for identifying changes in PTMs. In this review, we summarize the current literature on PTMs identified in the plasma and tumor tissue of breast-cancer patients or in breast cell lines. We also discuss some of the analytical techniques currently being used to evaluate PTMs.

  19. WIPP to Hold Public Meetings on Permit Modification Request

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    June 28, 2016 WIPP to Hold Public Meetings on Permit Modification Request The U.S. Department of Energy Carlsbad Field Office and Nuclear Waste Partnership LLC (Permittees) will conduct two public meetings on Tuesday, June 28, and Thursday, June 30, 2016. Tuesday, June 28, 2016 Thursday, June 30, 2016 3:00 to 5:00 P.M. 5:00 to 7:00 P.M. Courtyard by Marriott Skeen-Whitlock Building 3347 Cerrillos Road 4021 National Parks Highway Santa Fe, New Mexico Carlsbad, New Mexico The purpose of the

  20. Containment canister for capturing hazardous waste debris during piping modifications

    DOE Patents [OSTI]

    Dozier, Stanley B.

    2001-07-24

    The present invention relates to a capture and containment canister which reduces the risk of radiation and other biohazard exposure to workers, the need for a costly containment hut and the need for the extra manpower associated with the hut. The present invention includes the design of a canister having a specially designed magnetic ring that attracts and holds the top of the canister in place during modifications to gloveboxes and other types of radiological and biochemical hoods. The present invention also provides an improved hole saw that eliminates the need for a pilot bit.

  1. Nanoparticle modifications of photodefined nanostructures for energy applications.

    SciTech Connect (OSTI)

    Polsky, Ronen; Xiao, Xiaoyin; Burckel, David Bruce; Brozik, Susan Marie; Washburn, Cody M.; Wheeler, David Roger

    2011-10-01

    The advancement of materials technology towards the development of novel 3D nanostructures for energy applications has been a long-standing challenge. The purpose of this project was to explore photolithographically defineable pyrolyzed photoresist carbon films for possible energy applications. The key attributes that we explored were as follows: (1) Photo-interferometric fabrication methods to produce highly porous (meso, micro, and nano) 3-D electrode structures, and (2) conducting polymer and nanoparticle-modification strategies on these structures to provide enhanced catalytic capabilities and increase conductivity. The resulting electrodes were then explored for specific applications towards possible use in battery and energy platforms.

  2. Microsoft Word - Tribal DE-FOA-0001021- Modification 0004

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Questions about this FOA? Email tribal@ee.doe.gov. Problems with EERE Exchange? Email EERE-ExchangeSupport@hq.doe.gov. Include FOA name and number in subject line. DEPARTMENT OF ENERGY (DOE) OFFICE OF ENERGY EFFICIENCY AND RENEWABLE ENERGY (EERE) DEPLOYMENT OF CLEAN ENERGY AND ENERGY EFFICIENCY PROJECTS ON INDIAN LANDS Funding Opportunity Announcement (FOA) Number: DE-FOA-0001021 FOA Type: Modification 0004 CFDA Number: 81.087 FOA Issue Date: 07/16/2014 Informational Webinar 08/14/2014 at 1:00

  3. IPAGE OF PAGES AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    National Nuclear Security Administration (NNSA)

    I 1 2. AMENDMENT/MODIFICATION NO. 3. EFFECTIVE DATE 4. REQUISITION/PURCHASE REQ. NO. 15. PROJECT NO. (If appl/cab/e) 216 See Block 16C 6. ISSUED BY CODE 05007 7. ADMINISTERED BY (ffother than Ilem 6) CODE \05007 NNSA/Pantex Site Office NNSA/Pantex Site Office U.S. Department of Energy U.S. Department of Energy NNSA/Pantex Site Office NNSA/Pantex Site Office P.O. Box 30030 P.O. Box 30030 Amarillo TX 79120-0030 Amarillo TX 79120-0030 8. NAME AND ADDRESS OF CONTRACTOR (No., streot, county, S1ste

  4. PAGES AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    National Nuclear Security Administration (NNSA)

    1 PAGE 1 OF 2 PAGES AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 2. AMENDMENTIMODIFICATION NO. 13. EFFECTIVE DATE M186 October 15, 2009 4. REQUISITION/PURCHASE I 5. PROJECT NO. (If applicable) REQ. NO. 6. ISSUED BY CODE U.S. Department of Energy National Nuclear Security Administration Service Center Property and M&O Contract Support Department P.O. Box 5400 Albuquerque, NM 87185-5400 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy National Nuclear Security

  5. Signatures of initial state modifications on bispectrum statistics

    SciTech Connect (OSTI)

    Meerburg, P Daniel; Schaar, Jan Pieter van der; Corasaniti, Pier Stefano E-mail: j.p.vanderschaar@uva.nl

    2009-05-15

    Modifications of the initial-state of the inflaton field can induce a departure from Gaussianity and leave a testable imprint on the higher order correlations of the CMB and large scale structures in the Universe. We focus on the bispectrum statistics of the primordial curvature perturbation and its projection on the CMB. For a canonical single-field action the three-point correlator enhancement is localized, maximizing in the collinear limit, corresponding to enfolded or squashed triangles in comoving momentum space. We show that the available local and equilateral template are very insensitive to this localized enhancement and do not generate noteworthy constraints on initial-state modifications. On the other hand, when considering the addition of a dimension 8 higher order derivative term, we find a dominant rapidly oscillating contribution, which had previously been overlooked and whose significantly enhanced amplitude is independent of the triangle under consideration. Nevertheless, the oscillatory nature of (the sign of) the correlation function implies the signal is nearly orthogonal to currently available observational templates, strongly reducing the sensitivity to the enhancement. Constraints on departures from the standard Bunch-Davies vacuum state can be derived, but also depend on the next-to-leading terms. We emphasize that the construction and application of especially adapted templates could lead to CMB bispectrum constraints on modified initial states already competing with those derived from the power spectrum.

  6. Reduction of Glass Surface Reflectance by Ion Beam Surface Modification

    SciTech Connect (OSTI)

    Mark Spitzer

    2011-03-11

    This is the final report for DOE contract DE-EE0000590. The purpose of this work was to determine the feasibility of the reduction of the reflection from the front of solar photovoltaic modules. Reflection accounts for a power loss of approximately 4%. A solar module having an area of one square meter with an energy conversion efficiency of 18% generates approximately 180 watts. If reflection loss can be eliminated, the power output can be increased to 187 watts. Since conventional thin-film anti-reflection coatings do not have sufficient environmental stability, we investigated the feasibility of ion beam modification of the glass surface to obtain reduction of reflectance. Our findings are generally applicable to all solar modules that use glass encapsulation, as well as commercial float glass used in windows and other applications. Ion implantation of argon, fluorine, and xenon into commercial low-iron soda lime float glass, standard float glass, and borosilicate glass was studied by implantation, annealing, and measurement of reflectance. The three ions all affected reflectance. The most significant change was obtained by argon implantation into both low-iron and standard soda-lime glass. In this way samples were formed with reflectance lower than can be obtained with a single-layer coatings of magnesium fluoride. Integrated reflectance was reduced from 4% to 1% in low-iron soda lime glass typical of the glass used in solar modules. The reduction of reflectance of borosilicate glass was not as large; however borosilicate glass is not typically used in flat plate solar modules. Unlike conventional semiconductor ion implantation doping, glass reflectance reduction was found to be tolerant to large variations in implant dose, meaning that the process does not require high dopant uniformity. Additionally, glass implantation does not require mass analysis. Simple, high current ion implantation equipment can be developed for this process; however, before the process

  7. Ion beam modification of topological insulator bismuth selenide

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Sharma, Peter Anand; Sharma, A. L. Lima; Hekmaty, Michelle A.; Hattar, Khalid Mikhiel; Stavila, Vitalie; Goeke, Ronald S.; Erickson, K.; Medlin, Douglas L.; Brahlek, M.; Oh, S.; et al

    2014-12-17

    In this study, we demonstrate chemical doping of a topological insulator Bi2Se3 using ion implantation. Ion beam-induced structural damage was characterized using grazing incidence X-ray diffraction and transmission electron microscopy. Ion damage was reversed using a simple thermal annealing step. Carrier-type conversion was achieved using ion implantation followed by an activation anneal in Bi2Se3 thin films. These two sets of experiments establish the feasibility of ion implantation for chemical modification of Bi2Se3, a prototypical topological insulator. Ion implantation can, in principle, be used for any topological insulator. The direct implantation of dopants should allow better control over carrier concentrations formore » the purposes of achieving low bulk conductivity. Ion implantation also enables the fabrication of inhomogeneously doped structures, which in turn should make possible new types of device designs.« less

  8. Modifications to the FCHART/SLR version 2. 0 program

    SciTech Connect (OSTI)

    Hill, J. M.

    1981-07-01

    A number of errors have been detected in the FCHART/SLR computer code as it pertains to the thermal performance of passive solar energy systems. Along with minor coding changes, major revisions in the code have been made to improve the computer models used to predict the effects of overhangs on incident solar radiation and the radiation absorbed in attached sunspaces. Modifications to the code were also made to improve the handling of mullions and to reduce the effort required to describe the placement of overhangs. The theoretical basis of these changes, along with the associated alterations to the code, are given. For the cases examined, the program as modified now agrees to within 15% of published LANL passive system performance correlations. This new code has been designated as Version 2.1 and is presently operational at SSEC.

  9. Surface modification of zirconia-alumina composite ceramics

    SciTech Connect (OSTI)

    Ghosh, S.K.; Chatterjee, D.K.

    1994-12-31

    Surface modification of tetragonal zirconia and {alpha}-alumina composite was accomplished by diffusion of MgO during sintering at 1500{degrees}C. {alpha}-Al{sub 2}O{sub 3} powder, 2 to 60 wt%, was thoroughly mixed with 5 wt% yttria-alloyed zirconia powder, cold pressed and sintered in contact with fine MgO powder. In the diffusion zone, {alpha}-Al{sub 2}O{sub 3} was transformed to spinel, MgAl{sub 2}O{sub 4}, and transformation of tetragonal zirconia to cubic phase depended primarily on alumina concentration. The modified surface was, therefore, a composite of spinel, tetragonal (t) and/or cubic zirconia as distinguished from the core, comprised of {alpha}-Al{sub 2}O{sub 3} and t-ZrO{sub 2}. Tribological characteristics of the modified outer surface are also reported.

  10. Surface modification of multilayer graphene using Ga ion irradiation

    SciTech Connect (OSTI)

    Wang, Quan; Shao, Ying; Ge, Daohan; Ren, Naifei; Yang, Qizhi

    2015-04-28

    The effect of Ga ion irradiation intensity on the surface of multilayer graphene was examined. Using Raman spectroscopy, we determined that the irradiation caused defects in the crystal structure of graphene. The density of defects increased with the increase in dwell times. Furthermore, the strain induced by the irradiation changed the crystallite size and the distance between defects. These defects had the effect of doping the multilayer graphene and increasing its work function. The increase in work function was determined using contact potential difference measurements. The surface morphology of the multilayer graphene changed following irradiation as determined by atomic force microscopy. Additionally, the adhesion between the atomic force microscopy tip and sample increased further indicating that the irradiation had caused surface modification, important for devices that incorporate graphene.

  11. Surface modification of silicon nitride powder with aluminum

    SciTech Connect (OSTI)

    Han, K.R.; Lim, C.S.; Hong, M.J.; Choi, S.K.; Kwon, S.H.

    1996-02-01

    Surface modification of Si{sub 3}N{sub 4} with alumina was tried. It was achieved by simply mixing Si{sub 3}N{sub 4} powder with an alumina sol up to {approximately}2 wt% as alumina in an aqueous medium, dried, and followed by calcination at 400 C for 1 h. A TEM micrograph showed a coating layer of {approximately} 15 nm thickness. The isoelectric point of the modified Si{sub 3}N{sub 4} powder with porous alumina was at 0H 7.8, which is different from 5.8 and 8.6 for Si{sub 3}N{sub 4} and amorphous alumina, respectively.

  12. Modification of Doublet III to a large Dee facility

    SciTech Connect (OSTI)

    Davis, L.G.; Rawls, J.M.

    1981-10-01

    The Doublet III facility represents a unique opportunity to convert an existing device to a powerful test bed for FED design and operation issues. Such a conversion is made possible by virtue of the demountability of the devices toroidal field coils. Doublet III can be partially disassembled then reassembled with a large dee-shaped vacuum vessel and associated poloidal coils and structure. Doublet III presently possesses or is acquiring adequate auxiliary heating (14 MW of neutral beams and 2 MW of ECH), stored energy (3 GJ), and power conversion equipment (some added field shaping power equipment is required) to support large dee, reactor-level, plasma experiments. The only modifications required of the device are those directly caused by installing a larger vessel - the vessel itself (and its internal protection system); poloidal field coils that interfere with the larger vessel; and a support system for the new vessel and coils.

  13. Surface modification of low density silica and bridged polysilsesquioxane aerogels

    SciTech Connect (OSTI)

    DeFriend, K. A. (Kimberly A.); Loy, D. A. (Douglas A.); Salazar, K. V. (Kenneth V.); Wilson, K. V. (Kennard V.)

    2004-01-01

    Silica and bridged polysilsesquioxane aerogels are low density materials that are attractive for applications such as, thermal insulation, porous separation media or catalyst supports, adsorbents. However, aerogels are notoriously weak and brittle making it difficult to handle and machine monoliths into desired forms. This prevents the development of many applications that would otherwise benefit from the use of the low density materials. We will describe our efforts to chemically modify and mechanically enhance silica-based aerogels using chemical vapor techniques without sacrificing their characteristic low densities. Monolithic silica and organically bridged polysilsesquioxane aerogels were prepared by sol-gel polymerization of the respective methoxysilane monomers followed by supercritical carbon dioxide drying of the gels. Reactive modification of the gels with volatile silylating compounds during and after the drying process and these effects on the mechanical properties and density of the aerogels will be described.

  14. 327 Building liquid waste handling options modification project plan

    SciTech Connect (OSTI)

    Ham, J.E.

    1998-03-28

    This report evaluates the modification options for handling radiological liquid waste (RLW) generated during decontamination and cleanout of the 327 Building. The overall objective of the 327 Facility Stabilization Project is to establish a passively safe and environmentally secure configuration of the 327 Facility. The issue of handling of RLW from the 327 Facility (assuming the 34O Facility is not available to accept the RLW) has been conceptually examined in at least two earlier engineering studies (Parsons 1997a and Hobart l997). Each study identified a similar preferred alternative that included modifying the 327 Facility RLWS handling systems to provide a truck load-out station, either within the confines of the facility or exterior to the facility. The alternatives also maximized the use of existing piping, tanks, instrumentation, controls and other features to minimize costs and physical changes. An issue discussed in each study involved the anticipated volume of the RLW stream. Estimates ranged between 113,550 and 387,500 liters in the earlier studies. During the development of the 324/327 Building Stabilization/Deactivation Project Management Plan, the lower estimate of approximately 113,550 liters was confirmed and has been adopted as the baseline for the 327 Facility RLW stream. The goal of this engineering study is to reevaluate the existing preferred alternative and select a new preferred alternative, if appropriate. Based on the new or confirmed preferred alternative, this study will also provide a conceptual design and cost estimate for required modifications to the 327 Facility to allow removal of RLWS and treatment of the RLW generated during deactivation.

  15. Alteration and modulation of protein activity by varying post-translational modification

    SciTech Connect (OSTI)

    Thompson, David N; Reed, David W; Thompson, Vicki S; Lacey, Jeffrey A; Apel, William A

    2015-03-03

    Embodiments of the invention include methods of altering the enzymatic activity or solubility of an extremophilic enzyme or post-translationally modifying a protein of interest via using isolated or partially purified glycosyltransferases and/or post-translational modification proteins, extracts of cells comprising glycosyltransferases and/or post-translational modification proteins, and/or in cells comprising one or more glycosyltransferases and/or post-translational modification proteins.

  16. Contract DE-AC02-07CH11358 Modifications Language Changes

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    J.2, Appendix B - Performance Evaluation Measurement Plan (PEMP) (replaced Mod 164) * ... - Performance Evaluation Measurement Plan (PEMP) (replaced Mod 146) Modification 159 July ...

  17. Evaluation of the Cask Transportation Facility Modifications (CTFM) compliance to DOE order 6430.1A

    SciTech Connect (OSTI)

    ARD, K.E.

    1999-07-14

    This report was prepared to evaluate the compliance of Cask Transportation Facility Modifications (CTFM) to DOE Order 6430.1A.

  18. Probing the Influence of Stereoelectronic Effects on the Biophysical Properties of Oligonucleotides: Comprehensive Analysis of the RNA Affinity, Nuclease Resistance, and Crystal Structure of Ten 2'-O-Ribonucleic Acid Modifications

    SciTech Connect (OSTI)

    Egli, Martin; Minasov, George; Tereshko, Valentina; Pallan, Pradeep S.; Teplova, Marianna; Inamati, Gopal B.; Lesnik, Elena A.; Owens, Steve R.; Ross, Bruce S.; Prakash, Thazha P.; Manoharan, Muthiah

    2010-03-05

    The syntheses of 10 new RNA 2'-O-modifications, their incorporation into oligonucleotides, and an evaluation of their properties such as RNA affinity and nuclease resistance relevant to antisense activity are presented. All modifications combined with the natural phosphate backbone lead to significant gains in terms of the stability of hybridization to RNA relative to the first-generation DNA phosphorothioates (PS-DNA). The nuclease resistance afforded in particular by the 2'-O-modifications carrying a positive charge surpasses that of PS-DNA. However, small electronegative 2'-O-substituents, while enhancing the RNA affinity, do not sufficiently protect against degradation by nucleases. Similarly, oligonucleotides containing 3'-terminal residues modified with the relatively large 2'-O-[2-(benzyloxy)ethyl] substituent are rapidly degraded by exonucleases, proving wrong the assumption that steric bulk will generally improve protection against nuclease digestion. To analyze the factors that contribute to the enhanced RNA affinity and nuclease resistance we determined crystal structures of self-complementary A-form DNA decamer duplexes containing single 2'-O-modified thymidines per strand. Conformational preorganization of substituents, favorable electrostatic interactions between substituent and sugar-phosphate backbone, and a stable water structure in the vicinity of the 2'-O-modification all appear to contribute to the improved RNA affinity. Close association of positively charged substituents and phosphate groups was observed in the structures with modifications that protect most effectively against nucleases. The promising properties exhibited by some of the analyzed 2'-O-modifications may warrant a more detailed evaluation of their potential for in vivo antisense applications. Chemical modification of RNA can also be expected to significantly improve the efficacy of small interfering RNAs (siRNA). Therefore, the 2'-O-modifications introduced here may benefit the

  19. Surface engineering of the quality factor of metal coated microcantilevers

    SciTech Connect (OSTI)

    Ergincan, O.; Kooi, B. J.; Palasantzas, G.

    2014-12-14

    We performed noise measurements to obtain the quality factor (Q) and frequency shift of gold coated microcantilevers before and after surface modification using focused ion beam. As a result of our studies, it is demonstrated that surface engineering offers a promising method to control and increase the Q factor up to 50% for operation in vacuum. Surface modification could also lead to deviations from the known Q ∼ P{sup −1} behavior at low vacuum pressures P within the molecular regime. Finally, at higher pressures within the continuum regime, where Q is less sensitive to surface changes, a power scaling Q ∼ P{sup c} with c ≈ 0.3 was found instead of c = 0.5. The latter is explained via a semi-empirical formulation to account for continuum dissipation mechanisms at significant Reynolds numbers Re ∼ 1.

  20. Sorbent preparation/modification/additives. Final report, September 1, 1992--November 30, 1993

    SciTech Connect (OSTI)

    Prudich, M.E.; Venkataramakrishnan, R.

    1994-02-01

    Sorbent preparation techniques used today have generally been adapted from techniques traditionally used by the lime industry. Traditional dry hydration and slaking processes have been optimized to produce materials intended for use in the building industry. These preparation techniques should be examined with an eye to optimization of properties important to the SO{sub 2} capture process. The study of calcium-based sorbents for sulfur dioxide capture is complicated by two factors: (1) little is known about the chemical mechanisms by which the standard sorbent preparation and enhancement techniques work, and (2) a sorbent preparation technique that produces a calcium-based sorbent that enjoys enhanced calcium utilization in one regime of operation [flame zone (>2400 F), in-furnace (1600--2400 F), economizer (800--1100 F), after air preheater (<350 F)] may not produce a sorbent that enjoys enhanced calcium utilization in the other reaction zones. Again, an in-depth understanding of the mechanism of sorbent enhancement is necessary if a systematic approach to sorbent development is to be used. As a long-term goal, an experimental program is being carried out for the purpose of (1) defining the effects of slaking conditions on the properties of calcium-based sorbents, (2) determining how the parent limestone properties of calcium-based sorbents, and (3) elucidating the mechanism(s) relating to the activity of various dry sorbent additives. An appendix contains a one-dimensional duct injection model with modifications to handle the sodium additives.

  1. In-medium hadron modification and meson spectroscopy

    SciTech Connect (OSTI)

    Chaden Djalali, Dennis Weygand

    2010-04-01

    The theory of the strong interaction, Quantum Chromodynamics (QCD), has been remarkably successful in describing high-energy and short-distance-scale experiments involving quarks and gluons. However, applying QCD to low energy and large-distance-scale experiments has been a major challenge. At low energies, standard nuclear physics with nucleon and meson degrees of freedom work effectively in describing observations. The transition between the two descriptions of hadrons is one of the main goals of hadronic physics. Lattice QCD calculations have made tremendous progress and will one day give us a full description of strong interactions under all regimes. Meanwhile, effective theories incorporating some of the main features of QCD have been successfully developed and help us gain insight into the non-perturbative regime of QCD. All these models predict modifications of the properties of hadrons embedded in nuclear matter. Mesons with exotic quantum numbers are predicted at excitation energies below 2 GeV. Several experiments have been conducted with the Cebaf Large Acceptance Spectrometer (CLAS) at the Thomas Jefferson National Laboratory (JLab) to test these predictions.

  2. Lysine carboxylation: unveiling a spontaneous post-translational modification

    SciTech Connect (OSTI)

    Jimenez-Morales, David; Adamian, Larisa; Shi, Dashuang; Liang, Jie

    2014-01-01

    A computational method for the prediction of lysine carboxylation (KCX) in protein structures is described. The method accurately identifies misreported KCXs and predicts previously unknown KCX sites. The carboxylation of lysine residues is a post-translational modification (PTM) that plays a critical role in the catalytic mechanisms of several important enzymes. It occurs spontaneously under certain physicochemical conditions, but is difficult to detect experimentally. Its full impact is unknown. In this work, the signature microenvironment of lysine-carboxylation sites has been characterized. In addition, a computational method called Predictor of Lysine Carboxylation (PreLysCar) for the detection of lysine carboxylation in proteins with available three-dimensional structures has been developed. The likely prevalence of lysine carboxylation in the proteome was assessed through large-scale computations. The results suggest that about 1.3% of large proteins may contain a carboxylated lysine residue. This unexpected prevalence of lysine carboxylation implies an enrichment of reactions in which it may play functional roles. The results also suggest that by switching enzymes on and off under appropriate physicochemical conditions spontaneous PTMs may serve as an important and widely used efficient biological machinery for regulation.

  3. Just enough inflation: power spectrum modifications at large scales

    SciTech Connect (OSTI)

    Cicoli, Michele [Dipartimento di Fisica ed Astronomia, Universit di Bologna, via Irnerio 46, 40126 Bologna (Italy); Downes, Sean [Leung Center for Cosmology and Particle Astrophysics, National Taiwan University, No. 1, Section 4, Roosevelt Road, Taipei 10617, Taiwan (China); Dutta, Bhaskar [Mitchell Institute for Fundamental Physics and Astronomy, Department of Physics and Astronomy, Texas A and M University, College Station, TX 77843-4242 (United States); Pedro, Francisco G.; Westphal, Alexander, E-mail: mcicoli@ictp.it, E-mail: ssdownes@phys.ntu.edu.tw, E-mail: dutta@physics.tamu.edu, E-mail: francisco.pedro@desy.de, E-mail: alexander.westphal@desy.de [Deutsches Elektronen-Synchrotron DESY, Theory Group, D-22603 Hamburg (Germany)

    2014-12-01

    We show that models of 'just enough' inflation, where the slow-roll evolution lasted only 50- 60 e-foldings, feature modifications of the CMB power spectrum at large angular scales. We perform a systematic analytic analysis in the limit of a sudden transition between any possible non-slow-roll background evolution and the final stage of slow-roll inflation. We find a high degree of universality since most common backgrounds like fast-roll evolution, matter or radiation-dominance give rise to a power loss at large angular scales and a peak together with an oscillatory behaviour at scales around the value of the Hubble parameter at the beginning of slow-roll inflation. Depending on the value of the equation of state parameter, different pre-inflationary epochs lead instead to an enhancement of power at low ?, and so seem disfavoured by recent observational hints for a lack of CMB power at ??<40. We also comment on the importance of initial conditions and the possibility to have multiple pre-inflationary stages.

  4. Gelled polymer systems for permeability modification in petroleum reservoirs

    SciTech Connect (OSTI)

    Willhite, G.P.; Green, D.W.; Thiele, J.L.; McCool, C.S.; Mertes, K.B.

    1991-09-01

    The research program described in this report was conducted to improve the performance and predictability of in situ gelation processes designed to increase volumetric sweep efficiency of fluid displacement processes. A principal objective of this research was to develop procedures for design and evaluation of permeability modification processes. Research was conducted in three broad areas: (1) Physical and Chemical Characterization of Gelling Systems (2) In situ Gelation and (3) Mathematical Modeling of In Site Gelation. Gelling systems used chromium as the crosslinking agent. Polyacrylamide and polysaccharides gelling systems were studied. Research was conducted on the chemical structure of polymer/metal ion complexes, kinetics of the reduction of Cr(6) to Cr(3) by thiourea, kinetics of oligomerization and uptake of chromium by polyacrylamide and rheology of chromium/polysaccharide gelling systems. Studies of polymer/metal ion complexes were conducted using solutions of pure monomer, dimer and trimer forms of chromium. A mathematical model was developed to examine the kinetics of Cr(3) oligomerization and uptake of chromium by polyacrylamide. Rheological studies were completed on chromium/polysaccharide gels. In situ gelation experiments were conducted using a bis-ethylenediamine chromium complex and chromium(3) polyacrylamide gelling systems in sandpacks. A numerical model of in situ gelation of chromium/polyacrylamide systems was developed for linear displacement in a sandpack. The numerical model is based on filtration mechanisms and is consistent with experimental data and models developed in this research program. 103 figs., 21 tabs.

  5. Radwaste assessment program for nuclear station modifications by design engineering

    SciTech Connect (OSTI)

    Eble, R.G.

    1988-01-01

    Radwaste burial for Duke Power Company's (DPC's) seven nuclear units has become a complicated and costly process. Burial costs are based on overall volume, surcharges for radioactivity content and weight of containers, truck and cask rental, driver fees, and state fees and taxes. Frequently, radwaste costs can be as high as $500 per drum. Additionally, DPC is limited on the total burial space allocated for each plant each year. The thrust of this program is to reduce radwaste volumes needing burial at either Barnwell, South Carolina, or Richland, Washington. A limited number of options are available at our sites: (a) minimization of radwaste volume production, (b) segregation of contamination and noncontaminated trash, (c) decontamination of small hardware, (d) volume reduction of compatible trash, (e) incineration of combustible trash (available at Oconee in near future), and (f) burial of below-regulatory-concern very low level waste on site. Frequently, costs can be reduced by contracting services outside the company, i.e., supercompaction, decontamination, etc. Information about radwaste volumes, activities, and weight, however, must be provided to the nuclear production department (NPD) radwaste group early in the nuclear station modification (NSM) process to determine the most cost-effective method of processing radwaste. In addition, NSM radwaste costs are needed for the NPD NSM project budget. Due to the advanced planning scope of this budget, NSM construction costs must be estimated during the design-phase proposal.

  6. Modification of the Decontamination Facility at the Kruemmel NPP - 13451

    SciTech Connect (OSTI)

    Klute, Stefan; Kupke, Peter

    2013-07-01

    In February 2009, Siempelkamp Nukleartechnik GmbH was awarded the contract for the design, manufacture, delivery and construction of a new Decontamination Facility in the controlled area for Kruemmel NPP. The new decontamination equipment has been installed according to the state of art of Kruemmel NPP. The existing space required the following modification, retrofitting and reconstruction works: - Demounting of the existing installation: to create space for the new facility it was necessary to dismantle the old facility. The concrete walls and ceilings were cut into sizes of no more than 400 kg for ease of handling. This enabled decontamination so largest possible amount could be released for recycling. All steel parts were cut into sizes fitting for iron-barred boxes, respecting the requirement to render the parts decontaminable and releasable. - Reconstructing a decontamination facility: Reconstruction of a decontamination box with separate air lock as access area for the decontamination of components and assemblies was conducted using pressurized air with abrasives (glass beads or steel shots). The walls were equipped with sound protection, the inner walls were welded gap-free to prevent the emergence of interstices and were equipped with changeable wear and tear curtains. Abrasive processing unit positioned underneath the dry blasting box adjacent to the two discharge hoppers. A switch has been installed for the separation of the glass beads and the steel shot. The glass beads are directed into a 200 l drum for the disposal. The steel shot was cleaned using a separator. The cleaned steel shot was routed via transportation devices to the storage container, making it available for further blasting operations. A decontamination box with separate air lock as access area for the decontamination of components and assemblies using high pressure water technology was provided by new construction. Water pressures between 160 bar and 800 bar can be selected. The inner

  7. Modification of Thermal Emission via Metallic Photonic Crystals

    SciTech Connect (OSTI)

    Norris, David J.; Stein, Andreas; George, Steven M.

    2012-07-30

    Photonic crystals are materials that are periodically structured on an optical length scale. It was previously demonstrated that the glow, or thermal emission, of tungsten photonic crystals that have a specific structure - known as the 'woodpile structure' - could be modified to reduce the amount of infrared radiation from the material. This ability has implications for improving the efficiency of thermal emission sources and for thermophotovoltaic devices. The study of this effect had been limited because the fabrication of metallic woodpile structures had previously required a complex fabrication process. In this project we pursued several approaches to simplify the fabrication of metallic photonic crystals that are useful for modification of thermal emission. First, we used the self-assembly of micrometer-scale spheres into colloidal crystals known as synthetic opals. These opals can then be infiltrated with a metal and the spheres removed to obtain a structure, known as an inverse opal, in which a three-dimensional array of bubbles is embedded in a film. Second, we used direct laser writing, in which the focus of an infrared laser is moved through a thin film of photoresist to form lines by multiphoton polymerization. Proper layering of such lines can lead to a scaffold with the woodpile structure, which can be coated with a refractory metal. Third, we explored a completely new approach to modified thermal emission - thin metal foils that contain a simple periodic surface pattern, as shown in Fig. 1. When such a foil is heated, surface plasmons are excited that propagate along the metal interface. If these waves strike the pattern, they can be converted into thermal emission with specific properties.

  8. Comment re DOE's NOI re continuation or modification of Price-Anderson Act

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    | Department of Energy re DOE's NOI re continuation or modification of Price-Anderson Act Comment re DOE's NOI re continuation or modification of Price-Anderson Act Comments of Kerr-McGee Corporation to the "Notice of Inquiry" by DOE seeking comments to assist in the preparation of a report to Congress concerning the continuation or modification of the Price-Anderson Act (the "Act"). These comments will focus solely on question 25 of the notice -- namely, whether the

  9. Reducing Power Factor Cost

    Broader source: Energy.gov [DOE]

    Low power factor is expensive and inefficient. Many utility companies charge an additional fee if your power factor is less than 0.95. Low power factor also reduces your electrical system’s distribution capacity by increasing current flow and causing voltage drops. This fact sheet describes power factor and explains how you can improve your power factor to reduce electric bills and enhance your electrical system’s capacity.

  10. Contract DE-AC04-94AL85000 Modification M508

    National Nuclear Security Administration (NNSA)

    Contract DE-AC04-94AL85000 Modification M508 Attachment 1 SECTION J APPENDIX C Special Bank Account Agreement (Updated Mod M271, M461, M497, M508) Intentionally left blank for Internet posting purposes.

  11. Major Modification Determination Process Utilized for Proposed Idaho National Laboratory Projects

    SciTech Connect (OSTI)

    Michael A. Lehto, Ph.D.; Boyd D. Christensen

    2008-05-01

    Over the past three years, several new projects with the potential for major modifications to existing facilities have been considered for implementation at the Idaho National Laboratory (INL). These projects were designated to take place in existing nuclear facilities with existing documented safety analyses. 10 CFR 830.206 requires the contractor for a major modification to a Hazard Category 1, 2, or 3 nuclear facility to obtain Department of Energy (DOE) approval for the nuclear facility design criteria to be used for preparation of a preliminary documented safety analysis (PDSA), as well as creation and approval of the PDSA, before the contractor can procure materials or components or begin construction on the project. Given the significant effort and expense of preparation and approval of a PDSA, a major modification determination for new projects is warranted to determine if the rigorous requirements of a major modification are actually required. Furthermore, performing a major modification determination helps to ensure that important safety aspects of a project are appropriately considered prior to modification construction or equipment procurement. The projects considered for major modification status at the INL included: treatment and packaging of unirradiated, sodium-bonded highly enriched uranium (HEU) fuel and miscellaneous casting scrap in the Materials and Fuels Complex (MFC) Fuel Manufacturing Facility (FMF); post irradiation examination of Advance Fuel Cycle Initiative (AFCI) fuel in the MFC Analytical Laboratory (AL); the Advanced Test Reactor (ATR) gas test loop (GTL); and the hydraulic shuttle irradiation system (HSIS) at ATR. The major modification determinations for three of the proposed projects resulted in a negative major modification. On the other hand, the major modification determination for the GTL project concluded that the project would require a major modification. This paper discusses the process, methods, and considerations used by

  12. Modifications to incorporate competitive electricity prices in the annual energy outlook 1998 - electricity market module

    SciTech Connect (OSTI)

    1998-02-01

    The purpose of this report is to describe modifications to the Electricity Market Module (EMM) for the Annual Energy Outlook 1998. It describes revisions necessary to derive competitive electricity prices and the corresponding reserve margins.

  13. DE-AC27-I1ORVI15051 Modification A009

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of this modification is to make an equitable adjustment to contract cost relevant to transition cost and the stop work order dated November 27, 2009, and modify the period of...

  14. Modification of transparent materials with ultrashort laser pulses: What is energetically and mechanically meaningful?

    SciTech Connect (OSTI)

    Bulgakova, Nadezhda M.; Zhukov, Vladimir P.; Sonina, Svetlana V.; Meshcheryakov, Yuri P.

    2015-12-21

    A comprehensive analysis of laser-induced modification of bulk glass by single ultrashort laser pulses is presented which is based on combination of optical Maxwell-based modeling with thermoelastoplastic simulations of post-irradiation behavior of matter. A controversial question on free electron density generated inside bulk glass by ultrashort laser pulses in modification regimes is addressed on energy balance grounds. Spatiotemporal dynamics of laser beam propagation in fused silica have been elucidated for the regimes used for direct laser writing in bulk glass. 3D thermoelastoplastic modeling of material relocation dynamics under laser-induced stresses has been performed up to the microsecond timescale when all motions in the material decay. The final modification structure is found to be imprinted into material matrix already at sub-nanosecond timescale. Modeling results agree well with available experimental data on laser light transmission through the sample and the final modification structure.

  15. DOE Awards Task Order Modification for Support Services to Office of Environmental Management

    Broader source: Energy.gov [DOE]

    Cincinnati - The Department of Energy (DOE) today awarded a modification to Task Order DE-DT0005235 to J.G. Management Systems, Inc. of Grand Junction, CO for administrative and program analytical support for the Office of Environmental Management.

  16. Contract No. DE-AC04-94AL85000 Modification M0541

    National Nuclear Security Administration (NNSA)

    leadership. Revised M261; Replaced M271, M442, M483, M502, M0541 Contract No. DE-AC04-94AL85000 Modification No. M0541 Page 13 of 13 6. Matching employee donations to universities.

  17. Contract DE-AC04-94AL85000 Modification M508

    National Nuclear Security Administration (NNSA)

    Contract DE-AC04-94AL85000 Modification M508 Attachment 1 SECTION J APPENDIX C Special Bank Account Agreement (Updated Mod M271, M461, M497, M508) Intentionally left blank for ...

  18. Control Scheme Modifications Increase Efficiency of Steam Generation System at Exxon Mobil Gas Plant

    SciTech Connect (OSTI)

    2002-01-01

    This case study highlights control scheme modifications made to the steam system at ExxonMobil's Mary Ann Gas Plant in Mobile, Alabama, which improved steam flow efficiency and reduced energy costs.

  19. Occupational Health Services Part I DE-AC06-04RL14383, Modification...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Occupational Health Services Part I DE-AC06-04RL14383, Modification No. 171 Section B Page B-2 B.1 Occupational Medical Services a. This is a performance-based, cost reimbursement...

  20. Manipulating I V Characteristics of a Molecular Switch with Chemical Modifications

    SciTech Connect (OSTI)

    Palma, Julio L.; Cao, Chao; Zhang, Xiaoguang; Krstic, Predrag S; Krause, Jeffrey L.; Cheng, Hai-Ping

    2010-01-01

    We present a study of the effects of chemical modifications on the electron transport properties of the azobenzene molecule, which has been proposed as a component of a light-driven molecular switch. This molecule has two stable conformations (cis and trans) in the electronic ground state, with considerable differences in conductance. The electron transport properties were calculated using first-principles methods combining nonequilibrium Green s function techniques with density functional theory. Chemical modifications of the azobenzene consist of incorporation of electron-donating and electron-withdrawing groups in meta and ortho positions with respect to the azo group. The results show that the transport properties in electronic devices at the molecular level can be manipulated, enhanced, or suppressed by a careful consideration of the effects of chemical modification, and such modifications become crucial in optimizing the electron transport properties of chemical structures.

  1. Manipulating I-V Characteristics of a Molecular Switch with Chemical Modifications

    SciTech Connect (OSTI)

    Palma, Julio L.; Cao, Chao; Zhang, X.-G.; Krstic, Predrag S; Krause, Jeffrey L.; Cheng, Hai-Ping

    2010-01-01

    We present a study of the effects of chemical modifications on the electron transport properties of the azobenzene molecule, which has been proposed as a component of a light-driven molecular switch. This molecule has two stable conformations (cis and trans) in the electronic ground state, with considerable differences in conductance. The electron transport properties were calculated using first-principles methods combining nonequilibrium Green s function techniques with density functional theory. Chemical modifications of the azobenzene consist of incorporation of electron-donating and electron-withdrawing groups in meta and ortho positions with respect to the azo group. The results show that the transport properties in electronic devices at the molecular level can be manipulated, enhanced, or suppressed by a careful consideration of the effects of chemical modification, and such modifications become crucial in optimizing the electron transport properties of chemical structures.

  2. Modification of Lignin by Protein Cross-linking to Facilitate Production of

    Office of Scientific and Technical Information (OSTI)

    Biofuels From Poplar (Technical Report) | SciTech Connect Modification of Lignin by Protein Cross-linking to Facilitate Production of Biofuels From Poplar Citation Details In-Document Search Title: Modification of Lignin by Protein Cross-linking to Facilitate Production of Biofuels From Poplar The limited supply of fossil fuels and the associated environmental issues associated with their utilization has resulted in much effort put forth to promote renewable resources of energy. Switching to

  3. Fast Reactor Subassembly Design Modifications for Increasing Electricity Generation Efficiency

    SciTech Connect (OSTI)

    R. Wigeland; K. Hamman

    2009-09-01

    Suggested for Track 7: Advances in Reactor Core Design and In-Core Management _____________________________________________________________________________________ Fast Reactor Subassembly Design Modifications for Increasing Electricity Generation Efficiency R. Wigeland and K. Hamman Idaho National Laboratory Given the ability of fast reactors to effectively transmute the transuranic elements as are present in spent nuclear fuel, fast reactors are being considered as one element of future nuclear power systems to enable continued use and growth of nuclear power by limiting high-level waste generation. However, a key issue for fast reactors is higher electricity cost relative to other forms of nuclear energy generation. The economics of the fast reactor are affected by the amount of electric power that can be produced from a reactor, i.e., the thermal efficiency for electricity generation. The present study is examining the potential for fast reactor subassembly design changes to improve the thermal efficiency by increasing the average coolant outlet temperature without increasing peak temperatures within the subassembly, i.e., to make better use of current technology. Sodium-cooled fast reactors operate at temperatures far below the coolant boiling point, so that the maximum coolant outlet temperature is limited by the acceptable peak temperatures for the reactor fuel and cladding. Fast reactor fuel subassemblies have historically been constructed using a large number of small diameter fuel pins contained within a tube of hexagonal cross-section, or hexcan. Due to this design, there is a larger coolant flow area next to the hexcan wall as compared to flow area in the interior of the subassembly. This results in a higher flow rate near the hexcan wall, overcooling the fuel pins next to the wall, and a non-uniform coolant temperature distribution. It has been recognized for many years that this difference in sodium coolant temperature was detrimental to achieving

  4. Controlled levels of protein modification through a chromatography-mediated bioconjugation

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Kwant, Richard L.; Jaffe, Jake; Palmere, Peter J.; Francis, Matthew B.

    2015-02-27

    Synthetically modified proteins are increasingly finding applications as well-defined scaffolds for materials. In practice it remains difficult to construct bioconjugates with precise levels of modification because of the limited number of repeated functional groups on proteins. This article describes a method to control the level of protein modification in cases where there exist multiple potential modification sites. A protein is first tagged with a handle using any of a variety of modification chemistries. This handle is used to isolate proteins with a particular number of modifications via affinity chromatography, and then the handle is elaborated with a desired moiety usingmore » an oxidative coupling reaction. This method results in a sample of protein with a well-defined number of modifications, and we find it particularly applicable to systems like protein homomultimers in which there is no way to discern between chemically identical subunits. We demonstrate the use of this method in the construction of a protein-templated light-harvesting mimic, a type of system which has historically been difficult to make in a well-defined manner.« less

  5. Controlled levels of protein modification through a chromatography-mediated bioconjugation

    SciTech Connect (OSTI)

    Kwant, Richard L.; Jaffe, Jake; Palmere, Peter J.; Francis, Matthew B.

    2015-02-27

    Synthetically modified proteins are increasingly finding applications as well-defined scaffolds for materials. In practice it remains difficult to construct bioconjugates with precise levels of modification because of the limited number of repeated functional groups on proteins. This article describes a method to control the level of protein modification in cases where there exist multiple potential modification sites. A protein is first tagged with a handle using any of a variety of modification chemistries. This handle is used to isolate proteins with a particular number of modifications via affinity chromatography, and then the handle is elaborated with a desired moiety using an oxidative coupling reaction. This method results in a sample of protein with a well-defined number of modifications, and we find it particularly applicable to systems like protein homomultimers in which there is no way to discern between chemically identical subunits. We demonstrate the use of this method in the construction of a protein-templated light-harvesting mimic, a type of system which has historically been difficult to make in a well-defined manner.

  6. Maximum likelihood density modification by pattern recognition of structural motifs

    DOE Patents [OSTI]

    Terwilliger, Thomas C.

    2004-04-13

    An electron density for a crystallographic structure having protein regions and solvent regions is improved by maximizing the log likelihood of a set of structures factors {F.sub.h } using a local log-likelihood function: (x)+p(.rho.(x).vertline.SOLV)p.sub.SOLV (x)+p(.rho.(x).vertline.H)p.sub.H (x)], where p.sub.PROT (x) is the probability that x is in the protein region, p(.rho.(x).vertline.PROT) is the conditional probability for .rho.(x) given that x is in the protein region, and p.sub.SOLV (x) and p(.rho.(x).vertline.SOLV) are the corresponding quantities for the solvent region, p.sub.H (x) refers to the probability that there is a structural motif at a known location, with a known orientation, in the vicinity of the point x; and p(.rho.(x).vertline.H) is the probability distribution for electron density at this point given that the structural motif actually is present. One appropriate structural motif is a helical structure within the crystallographic structure.

  7. Gross alpha analytical modifications that improve wastewater treatment compliance

    SciTech Connect (OSTI)

    Tucker, B.J.; Arndt, S.

    2007-07-01

    This paper will propose an improvement to the gross alpha measurement that will provide more accurate gross alpha determinations and thus allow for more efficient and cost-effective treatment of site wastewaters. To evaluate the influence of salts that may be present in wastewater samples from a potentially broad range of environmental conditions, two types of efficiency curves were developed, each using a thorium-230 (Th-230) standard spike. Two different aqueous salt solutions were evaluated, one using sodium chloride, and one using salts from tap water drawn from the Bergen County, New Jersey Publicly Owned Treatment Works (POTW). For each curve, 13 to 17 solutions were prepared, each with the same concentration of Th-230 spike, but differing in the total amount of salt in the range of 0 to 100 mg. The attenuation coefficients were evaluated for the two salt types by plotting the natural log of the counted efficiencies vs. the weight of the sample's dried residue retained on the planchet. The results show that the range of the slopes for each of the attenuation curves varied by approximately a factor of 2.5. In order to better ensure the accuracy of results, and thus verify compliance with the gross alpha wastewater effluent criterion, projects depending on gross alpha measurements of environmental waters and wastewaters should employ gross alpha efficiency curves prepared with salts that mimic, as closely as possible, the salt content of the aqueous environmental matrix. (authors)

  8. GENOME ENABLED MODIFICATION OF POPLAR ROOT DEVELOPMENT FOR INCREASED CARBON SEQUESTRATION

    SciTech Connect (OSTI)

    Busov, Victor

    2013-03-05

    the stress response. Here we summarize progress in identification of three classes of genes useful for control of plant architecture: those affecting hormone metabolism and signaling; transcription and other regulatory factors; and the cell cycle. We focus on strong modifiers of stature and form that may be useful for directed modification of plant architecture, rather than the detailed mechanisms of gene action. Gibberellin (GA) metabolic and response genes are particularly attractive targets for manipulation because many act in a dose-dependent manner; similar phenotypic effects can be readily achieved in heterologous species; and induced pleiotropic effects--such as on nitrogen assimilation, photosynthesis, and lateral root production--are usually positive with respect to crop performance. Genes encoding transcription factors represent strong candidates for manipulation of plant architecture. For example, AINTEGUMENTA, ARGOS (auxin-regulated gene controlling organ size), and growth-regulating factors (GRFs) are strong modifiers of leaf and/or flower size. Plants overexpressing these genes had increased organ size and did not display negative pleiotropic effects in glasshouse environments. TCP-domain genes such as CINCINNATA, and the associated regulatory miRNAs such as miRJAW, may provide useful means to modulate leaf curvature and other foliage properties. There are considerable opportunities for comparative and translational genomics in nonmodel plant systems.

  9. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 11. CONTRACT ID CODE

    National Nuclear Security Administration (NNSA)

    -------------------------------------------------------- AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 11. CONTRACT ID CODE I PAGE OF PAGES 1 I 2 2. AMENDMENT/MODIFICATION NO. 3. EFFECTIVE DATE 4. REQUISITION/PURCHASE REQ. NO. 15. PROJECT NO. (If applicable) 0246 See Block 16C 6. ISSUED BY CODE 05003 7. ADMINISTERED BY (If other than Item 6) CODE 105003 NNSA/Los Alamos Site Office NNSA/Los Alamos Site Office U.S. Department of Energy U.S. Department of Energy NNSA/Los Alamos Site Office Los

  10. DE-AC27-10RV15051 Modification A001

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    DE-AC27-10RV15051 Modification A001 Page 2 of 12 The purpose of this change order is to (1) add American Recovery and Reinvestment Act (ARRA) tasks (2) obligate ARRA funding, (3) incorporate applicable ARRA clauses. 1. CHANGE ORDER This change order modification is issued pursuant to contract clause I-75, entitled FAR 52.243-2 - Changes - Cost-Reimbursement (Aug 1987), Alternate I (Apr 1984). Under this authority the contractor is directed to proceed with performance of ARRA tasks as outlined

  11. DE-AC27-I1ORVI15051 Modification A009

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    I1ORVI15051 Modification A009 Page 2 of 6 A. The purpose of this modification is to make an equitable adjustment to contract cost relevant to transition cost and the stop work order dated November 27, 2009, and modify the period of performance as detailed below: Reference: 1. ATL Letter dated May 24, 2010, from J.G. Hwang, ATL, to D.A. Gallegos, ORP, "CLIN 1 TRANSITION COST OVERRUN PROPOSAL (Contract Number DE-AC27-1I0RV 1505 1) Background: The contract was awarded on November 20, 2009, and

  12. Modifications Made to the MELCOR Code for Analyzing Lithium Fires in Fusion Reactors

    SciTech Connect (OSTI)

    Merrill, Brad Johnson

    2000-04-01

    This report documents initial modifications made to the MELCOR code that allows MELCOR to predict the consequences of lithium spill accidents for evolving fusion reactor designs. These modifications include thermodynamic and transport properties for lithium, and physical models for predicting the rate of reaction of and energy production from the lithium-air reaction. A benchmarking study was performed with this new MELCOR capability. Two lithium-air reaction tests conducted at the Hanford Engineering Development Laboratory (HEDL) were selected for this benchmark study. Excellent agreement was achieved between MELCOR predictions and measured data. Recommendations for modeling lithium fires with MELCOR and for future work in this area are included in this report.

  13. Modifications made to the MELCOR Code for Analyzing Lithium Fires in Fusion Reactors

    SciTech Connect (OSTI)

    B. J. Merrill

    2000-04-01

    This report documents initial modifications made to the MELCOR code that allows MELCOR to predict the consequences of lithium spill accidents for evolving fusion reactor designs. These modifications include thermodynamic and transport properties for lithium, and physical models for predicting the rate of reaction of and energy production from the lithium-air reaction. A benchmarking study was performed with this new MELCOR capability. Two lithium-air reaction tests conducted at the Hanford Engineering Development Laboratory (HEDL) were selected for this benchmark study. Excellent agreement was achieved between MELCOR predictions and measured data. Recommendations for modeling lithium fires with MELCOR and for future work in this area are included in this report.

  14. AMEN DMENT OF SOLICITATION/MODIFICATION OF CONTRACT r* CONTRACT ID CODE

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AME:NDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1. CONTRACT 10 CODE PAGE 1 OF 224 PAGES 2. AMENDMENT/MODIFICATION NO. M202 3. EFFECTIVE DATE October 1, 2003 4. REQUISITION/PURCHASE REQ. NO. 5. PROJECT NO. (If applicable) 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.s. Department of Energy N.itional Nuclear Security Administration Sandia Site Office Mail Stop 0184 P.O. Box 5400 AlbuauerQue, NM 87185-5400 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, state, ZIP

  15. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1. CONTRACT ID CODE PAGE OF PAGES

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1. CONTRACT ID CODE PAGE OF PAGES 1 20 2. AMENDMENT/MODIFICATION NO. A001 3. EFFECTIVE DATE See Block 16C 4. REQUISITION/PURCHASE REQ. NO. 5. PROJECT NO. (If applicable) 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy National Energy Technology Laboratory PO Box 880, 3610 Collins Ferry Road Morgantown, WV 26507-0880 Attn: Amanda Lopez 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State, and

  16. Microsoft Word - Final Class 2 Permit Modification Request TRUPACT III.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    January 10, 2011 Mr. James Bearzi. Chief Hazardous Waste Bureau New Mexico Environment Department 2905 Rodeo Park Drive East, Building 1 Santa Fe, New Mexico 87505-6303 Subject: Notification of a Class 2 Permit Modification to Permit Number: NM4890139088-TSDF Dear Mr. Bearzi: Enclosed is a Class 2 Permit Modification Request to: * Add TRUPACT-II I and Standard Large Box 2 * Revise Area of Contact-Handled Bay We certify under penalty of law that this document and the enclosure were prepared under

  17. 1,CONTRACT ID CODE PAGE OF PAGES AMENDMENT OF SOLICITATION/MODIFICATION

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    1 1 (10.63 MB) More Documents & Publications Microsoft Word - GJPPGPracticesDraft.doc Updated Section H Greening Clauses DOE Purchase Card Policy

    ,CONTRACT ID CODE PAGE OF PAGES AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT I 11 3 2. AMENDMENT/MODIFICATION NO. 3. EFFECTIVE DATE (M D Y) 4. REQUISITION/PURCHASE REQ. NO. 5. PROJECT NO, (If applicable) 221 See Block 16C 11 EM0026551 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy Office of

  18. 1. CNTRAT IDCODE PAGE OF PGES AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    CNTRAT IDCODE PAGE OF PGES AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1 OTATI OEPG FIP 5S 2, AMENDMENT/MODIFICATION NO. 3. EFFECTIVE DATE (M/IJ/Y) 4. REQUISITION/PURCHASE REQ. NO. 5. PROJECT NO. (If applicable) 313 See Block 16C1 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy Office of River Protection P. 0. Box 450, MIS H6-60 Richland, WA 99352 8. NAME AND ADDRESS OF CONTRACTOR (No., stree, county, Slate and ZIP code) 9A. AMENDMENT OF

  19. Modification No. M226 Contract No. DE-AC54-00AL66620

    National Nuclear Security Administration (NNSA)

    Modification No. M226 Contract No. DE-AC54-00AL66620 Page No. 2 of 2 The purpose of this Modification is to incorporate the following: A. Replace Part III, LIST OF DOCUMENTS, EXHIBITS, AND OTHER ATTACHMENTS, Section J - LIST OF ATTACHMENTS, Appendix A - PERSONNEL APPENDIX in its entirety to update REIMBURSEMENT AUTHORIZATIONS, TABLE OF CONTENTS, to add "I. Exempt Compensatory Time" and "J. Additional Bonus for Non-Key Personnel" to Section I. COMPENSATION SYSTEM, and to

  20. Contract No. DE-AC02-07CH11358 Section E Contract Modification No. 133

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    E Contract Modification No. 133 i PART I SECTION E INSPECTION AND ACCEPTANCE PAGE NO. E.1 - FAR 52.246-9 - INSPECTION OF RESEARCH AND DEVELOPMENT (SHORT FORM) (APR 1984) E-1 E.2 - CERTIFICATION E-1 Contract No. DE-AC02-07CH11358 Section E Contract Modification No.133 E-1 PART I SECTION E - INSPECTION AND ACCEPTANCE E.1 - FAR 52.246-9 - INSPECTION OF RESEARCH AND DEVELOPMENT (SHORT FORM) (APR 1984) The Government has the right to inspect and evaluate the work performed or being performed under

  1. Contract No. DE-AC02-07CH11358 Section F Contract Modification No. 0139

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    F Contract Modification No. 0139 i PART I SECTION F DELIVERIES OR PERFORMANCE TABLE OF CONTENTS PAGE NO. F.1 - PERIOD OF PERFORMANCE F-1 F.2 - AWARD TERM INCENTIVE (SPECIAL) F-1 F.3 - FAR 52.242-15 - STOP WORK ORDER (AUG 1989) - ALTERNATE I (APR 1984) F-4 F.4 - STOP WORK AND SHUTDOWN AUTHORITY F-5 F.5 - PRINCIPAL PLACE OF PERFORMANCE F-5 Contract No. DE-AC02-07CH11358 Section F Contract Modification No. 0139 F-1 PART I SECTION F - DELIVERIES OR PERFORMANCE F.1 - PERIOD OF PERFORMANCE (a) This

  2. Contract Number DE-AC27-08RV14800 Continuation Page, Modification 371

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Contract Number DE-AC27-08RV14800 Continuation Page, Modification 371 Attachment DE-AC27-08RV14800, MODIFICATION 371 Replacement Pages (Total: 19 including this Cover Page) * Section C, Statement of Work, pages C-11, C-18, C-45 thru C-47, C-49, C-54, C-56 and C-64 * Section J.2, Requirement Sources and Implementing Documents, pages J.2-2 thru J.2-4 * Section J.9, Special Financial Institution Account Agreement For Use With The Payments Cleared Financing Arrangement, pages J.9-1 thru J.9-5 *

  3. EIS-0435: Modification of the Groton Generation Station Interconnection Agreement, Brown County, South Dakota

    Broader source: Energy.gov [DOE]

    This EIS evaluates the environmental impacts of a proposal for DOE's Western Area Power Administration to modify its Large Generator Connection Agreement for the Groton Generation Station in Brown County, South Dakota. The modification would allow Basin Electric Power Cooperative, which operates the generation station, to produce power above the current operating limit of 50 average megawatts.

  4. Liquid phase methanol LaPorte process development unit: Modification, operation, and support studies

    SciTech Connect (OSTI)

    Not Available

    1991-02-02

    This report consists of Detailed Data Acquisition Sheets for Runs E-6 and E-7 for Task 2.2 of the Modification, Operation, and Support Studies of the Liquid Phase Methanol Laporte Process Development Unit. (Task 2.2: Alternate Catalyst Run E-6 and Catalyst Activity Maintenance Run E-7).

  5. Reducing Power Factor Cost

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... The presence of both in the same circuit results in the continuous alternating transfer of ... In the diagram below, the power triangle shows an initial 0.70 power factor for a 100-kW ...

  6. FGF growth factor analogs

    DOE Patents [OSTI]

    Zamora, Paul O.; Pena, Louis A.; Lin, Xinhua; Takahashi, Kazuyuki

    2012-07-24

    The present invention provides a fibroblast growth factor heparin-binding analog of the formula: ##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, X, Y and Z are as defined, pharmaceutical compositions, coating compositions and medical devices including the fibroblast growth factor heparin-binding analog of the foregoing formula, and methods and uses thereof.

  7. Modulation of farnesoid X receptor results in post-translational modification of poly (ADP-ribose) polymerase 1 in the liver

    SciTech Connect (OSTI)

    Zhu, Yan; Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS ; Li, Guodong; Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS ; Dong, Yafeng; Zhou, Helen H.; Kong, Bo; Aleksunes, Lauren M.; Richardson, Jason R.; Li, Fei; Guo, Grace L.

    2013-01-15

    The farnesoid X receptor (FXR) is a bile acid-activated transcription factor belonging to the nuclear receptor superfamily. FXR deficiency in mice results in cholestasis, metabolic disorders, and tumorigenesis in liver and intestine. FXR is known to contribute to pathogenesis by regulating gene transcription; however, changes in the post-transcriptional modification of proteins associated with FXR modulation have not been determined. In the current study, proteomic analysis of the livers of wild-type (WT) and FXR knockout (FXR-KO) mice treated with a FXR synthetic ligand or vehicle was performed. The results identified five proteins as novel FXR targets. Since FXR deficiency in mice leads to liver tumorigenesis, poly (ADP-ribose) polymerase family, member 1 (Parp1) that is important for DNA repair, was validated in the current study by quantitative real-time PCR, and 1- and 2-dimensional gel electrophoresis/western blot. The results showed that Parp1 mRNA levels were not altered by FXR genetic status or by agonist treatment. However, total Parp1 protein levels were increased in FXR-KO mice as early as 3 month old. Interestingly, total Parp1 protein levels were increased in WT mice in an age-dependent manner (from 3 to 18 months), but not in FXR-KO mice. Finally, activation of FXR in WT mice resulted in reduction of phosporylated Parp1 protein in the liver without affecting total Parp1 protein levels. In conclusion, this study reveals that FXR genetic status and agonist treatment affects basal levels and phosphorylation state of Parp1, respectively. These alterations, in turn, may be associated with the hepatobiliary alterations observed in FXR-KO mice and participate in FXR agonist-induced protection in the liver. -- Highlights: ? Proteomic analysis identified novel FXR targets. ? FXR modification altered post-translational modification of the Parp1 protein. ? Altered Parp1 function may contribute to mechanisms of FXR regulation of liver functions.

  8. WTP Contract Section D Contract No. DE-AC27-01RV14136 Conformed Thru Modification No. A143

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    D Contract No. DE-AC27-01RV14136 Conformed Thru Modification No. A143 D - i SECTION D PACKAGING AND MARKING WTP Contract Section D Contract No. DE-AC27-01RV14136 Conformed Thru Modification No. A143 D - ii SECTION D PACKAGING AND MARKING TABLE OF CONTENTS Section Clauses Page D.1 PACKAGING .................................................................................................................................... 1 D.2 MARKING

  9. Modification of electron states in CdTe absorber due to a buffer layer in CdTe/CdS solar cells

    SciTech Connect (OSTI)

    Fedorenko, Y. G. Major, J. D.; Pressman, A.; Phillips, L. J.; Durose, K.

    2015-10-28

    By application of the ac admittance spectroscopy method, the defect state energy distributions were determined in CdTe incorporated in thin film solar cell structures concluded on ZnO, ZnSe, and ZnS buffer layers. Together with the Mott-Schottky analysis, the results revealed a strong modification of the defect density of states and the concentration of the uncompensated acceptors as influenced by the choice of the buffer layer. In the solar cells formed on ZnSe and ZnS, the Fermi level and the energy position of the dominant deep trap levels were observed to shift closer to the midgap of CdTe, suggesting the mid-gap states may act as recombination centers and impact the open-circuit voltage and the fill factor of the solar cells. For the deeper states, the broadening parameter was observed to increase, indicating fluctuations of the charge on a microscopic scale. Such changes can be attributed to the grain-boundary strain and the modification of the charge trapped at the grain-boundary interface states in polycrystalline CdTe.

  10. Multi-factor authentication

    DOE Patents [OSTI]

    Hamlet, Jason R; Pierson, Lyndon G

    2014-10-21

    Detection and deterrence of spoofing of user authentication may be achieved by including a cryptographic fingerprint unit within a hardware device for authenticating a user of the hardware device. The cryptographic fingerprint unit includes an internal physically unclonable function ("PUF") circuit disposed in or on the hardware device, which generates a PUF value. Combining logic is coupled to receive the PUF value, combines the PUF value with one or more other authentication factors to generate a multi-factor authentication value. A key generator is coupled to generate a private key and a public key based on the multi-factor authentication value while a decryptor is coupled to receive an authentication challenge posed to the hardware device and encrypted with the public key and coupled to output a response to the authentication challenge decrypted with the private key.

  11. Geothermal Plant Capacity Factors

    SciTech Connect (OSTI)

    Greg Mines; Jay Nathwani; Christopher Richard; Hillary Hanson; Rachel Wood

    2015-01-01

    The capacity factors recently provided by the Energy Information Administration (EIA) indicated this plant performance metric had declined for geothermal power plants since 2008. Though capacity factor is a term commonly used by geothermal stakeholders to express the ability of a plant to produce power, it is a term frequently misunderstood and in some instances incorrectly used. In this paper we discuss how this capacity factor is defined and utilized by the EIA, including discussion on the information that the EIA requests from operations in their 923 and 860 forms that are submitted both monthly and annually by geothermal operators. A discussion is also provided regarding the entities utilizing the information in the EIA reports, and how those entities can misinterpret the data being supplied by the operators. The intent of the paper is to inform the facility operators as the importance of the accuracy of the data that they provide, and the implications of not providing the correct information.

  12. Performance of non-conventional factorization approaches for neutron kinetics

    SciTech Connect (OSTI)

    Bulla, S.; Nervo, M.

    2013-07-01

    The use of factorization techniques provides a interesting option for the simulation of the time-dependent behavior of nuclear systems with a reduced computational effort. While point kinetics neglects all spatial and spectral effects, quasi-statics and multipoint kinetics allow to produce results with a higher accuracy for transients involving relevant modifications of the neutron distribution. However, in some conditions these methods can not work efficiently. In this paper, we discuss some possible alternative formulations for the factorization process for neutron kinetics, leading to mathematical models of reduced complications that can allow an accurate simulation of transients involving spatial and spectral effects. The performance of these innovative approaches are compared to standard techniques for some test cases, showing the benefits and shortcomings of the method proposed. (authors)

  13. Radiation View Factor With Shadowing

    Energy Science and Technology Software Center (OSTI)

    1992-02-24

    FACET calculates the radiation geometric view factor (alternatively called shape factor, angle factor, or configuration factor) between surfaces for axisymmetric, two-dimensional planar and three-dimensional geometries with interposed third surface obstructions. FACET was developed to calculate view factors as input data to finite element heat transfer analysis codes.

  14. Inelastic Scattering Form Factors

    Energy Science and Technology Software Center (OSTI)

    1992-01-01

    ATHENA-IV computes form factors for inelastic scattering calculations, using single-particle wave functions that are eigenstates of motion in either a Woods-Saxon potential well or a harmonic oscillator well. Two-body forces of Gauss, Coulomb, Yukawa, and a sum of cut-off Yukawa radial dependences are available.

  15. ERYTHROPOIETIC FACTOR PURIFICATION

    DOE Patents [OSTI]

    White, W.F.; Schlueter, R.J.

    1962-05-01

    A method is given for purifying and concentrating the blood plasma erythropoietic factor. Anemic sheep plasma is contacted three times successively with ion exchange resins: an anion exchange resin, a cation exchange resin at a pH of about 5, and a cation exchange resin at a pH of about 6. (AEC)

  16. Two-Factor Authentication

    Broader source: Energy.gov [DOE]

    Two-Factor Authentication (2FA) (also known as 2-Step Verification) is a system that employs two methods to identify an individual. More secure than reusable passwords, when a token's random number...

  17. Two-dimensional nanostructured Y{sub 2}O{sub 3} particles for viscosity modification

    SciTech Connect (OSTI)

    He, Xingliang; Xiao, Huaping; Liang, Hong; Kyle, Jonathan P.; Terrell, Elon J.

    2014-04-21

    Nanoparticle additives have been shown to improve the mechanical and transport phenomena of various liquids; however, little has been done to try and explain the rheological modifications provided from such modifications from a theoretical standpoint. Here, we report a non-Einstein-like reduction of viscosity of mineral oil with the utilization of yttrium oxide nanosheet additives. Experimental results, coupled with generalized smoothed-particle hydrodynamics simulations, provide insight into the mechanism behind this reduction of fluid shear stress. The ordered inclination of these two-dimensional nanoparticle additives markedly improves the lubricating properties of the mineral oil, ultimately reducing the friction, and providing a way in designing and understanding next generation of lubricants.

  18. The role of electronic energy loss in ion beam modification of materials

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Weber, William J.; Duffy, Dorothy M.; Thome, Lionel; Zhang, Yanwen

    2014-10-05

    The interaction of energetic ions with solids results in energy loss to both atomic nuclei and electrons in the solid. In this article, recent advances in understanding and modeling the additive and competitive effects of nuclear and electronic energy loss on the response of materials to ion irradiation are reviewed. Experimental methods and large-scale atomistic simulations are used to study the separate and combined effects of nuclear and electronic energy loss on ion beam modification of materials. The results demonstrate that nuclear and electronic energy loss can lead to additive effects on irradiation damage production in some materials; while inmore » other materials, the competitive effects of electronic energy loss leads to recovery of damage induced by elastic collision cascades. Lastly, these results have significant implications for ion beam modification of materials, non-thermal recovery of ion implantation damage, and the response of materials to extreme radiation environments.« less

  19. Contract Number DE-AC27-08RV14800 Continuation Page, Modification 138

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Contract Number DE-AC27-08RV14800 Continuation Page, Modification 138 Attachment 1 DE-AC27-08RV14800, MODIFICATION 138 Replacement Pages (Total: One Hundred Twenty-Five (125) including this Cover Page) * Section H, Pages H-4 and H-24 * Section J, Table of Contents, Page J-1 * Section J, Attachment J.2, Pages J.2-4 thru J.2-7 and J.2.9 * Section J, Attachment J.10, Pages J.10-1 thru J.10-20 * Section J, Attachment J.13, Pages J.13-1 thru J.13-29 * Section J, Attachment J.14, Pages J.14-1 thru

  20. Modification of surface oxide layers of titanium targets for increasing lifetime of neutron tubes

    SciTech Connect (OSTI)

    Zakharov, A. M. Dvoichenkova, O. A.; Evsin, A. E.

    2015-12-15

    The peculiarities of interaction of hydrogen ions with a titanium target and its surface oxide layer were studied. Two ways of modification of the surface oxide layers of titanium targets for increasing the lifetime of neutron tubes were proposed: (1) deposition of an yttrium oxide barrier layer on the target surface; (2) implementation of neutron tube work regime in which the target is irradiated with ions with energies lower than 1000 eV between high-energy ion irradiation pulses.

  1. Mediating Biofuel Complexity through "Mediator" Modification | U.S. DOE

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Office of Science (SC) Mediating Biofuel Complexity through "Mediator" Modification Basic Energy Sciences (BES) BES Home About Research Facilities Science Highlights Benefits of BES Funding Opportunities Basic Energy Sciences Advisory Committee (BESAC) Community Resources Contact Information Basic Energy Sciences U.S. Department of Energy SC-22/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3081 F: (301) 903-6594 E: Email Us More Information »

  2. Surface modification to improve fireside corrosion resistance of Fe-Cr ferritic steels

    DOE Patents [OSTI]

    Park, Jong-Hee; Natesan, Krishnamurti; Rink, David L.

    2010-03-16

    An article of manufacture and a method for providing an Fe--Cr ferritic steel article of manufacture having a surface layer modification for corrosion resistance. Fe--Cr ferritic steels can be modified to enhance their corrosion resistance to liquid coal ash and other chemical environments, which have chlorides or sulfates containing active species. The steel is modified to form an aluminide/silicide passivating layer to reduce such corrosion.

  3. Sandia Corporation, Contract No. DE-AC04-94AL85000 Modification No. M537

    National Nuclear Security Administration (NNSA)

    Corporation, Contract No. DE-AC04-94AL85000 Modification No. M537 Attachment 1 Part III - Section J Appendix G List of Applicable Directives and NNSA Policy Letters In addition to the list of applicable directives referenced below, the contractor shall also comply with supplementary directives (e.g., manuals), which are invoked by a Contractor Requirements Document (CRD) attached to a directive referenced below. This List excludes directives that have been granted an exemption from the CRD in

  4. BuD, a helixloophelix DNA-binding domain for genome modification

    SciTech Connect (OSTI)

    Stella, Stefano; Molina, Rafael; Lpez-Mndez, Blanca; Juillerat, Alexandre; Bertonati, Claudia; Daboussi, Fayza; Campos-Olivas, Ramon; Duchateau, Phillippe; Montoya, Guillermo

    2014-07-01

    Crystal structures of BurrH and the BurrHDNA complex are reported. DNA editing offers new possibilities in synthetic biology and biomedicine for modulation or modification of cellular functions to organisms. However, inaccuracy in this process may lead to genome damage. To address this important problem, a strategy allowing specific gene modification has been achieved through the addition, removal or exchange of DNA sequences using customized proteins and the endogenous DNA-repair machinery. Therefore, the engineering of specific proteinDNA interactions in protein scaffolds is key to providing toolkits for precise genome modification or regulation of gene expression. In a search for putative DNA-binding domains, BurrH, a protein that recognizes a 19 bp DNA target, was identified. Here, its apo and DNA-bound crystal structures are reported, revealing a central region containing 19 repeats of a helixloophelix modular domain (BurrH domain; BuD), which identifies the DNA target by a single residue-to-nucleotide code, thus facilitating its redesign for gene targeting. New DNA-binding specificities have been engineered in this template, showing that BuD-derived nucleases (BuDNs) induce high levels of gene targeting in a locus of the human haemoglobin ? (HBB) gene close to mutations responsible for sickle-cell anaemia. Hence, the unique combination of high efficiency and specificity of the BuD arrays can push forward diverse genome-modification approaches for cell or organism redesign, opening new avenues for gene editing.

  5. Contract No. DE-AC06-97RL13184, Modification 158 Attachment J-1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    6-97RL13184, Modification 158 Attachment J-1 Page 1 of 9 WD 05-2569 (Rev.-14) was first posted on www.wdol.gov on 06/19/2012 ************************************************************************************ REGISTER OF WAGE DETERMINATIONS UNDER | U.S. DEPARTMENT OF LABOR THE SERVICE CONTRACT ACT | EMPLOYMENT STANDARDS ADMINISTRATION By direction of the Secretary of Labor | WAGE AND HOUR DIVISION | WASHINGTON D.C. 20210 | | | | Wage Determination No.: 2005-2569 Diane C. Koplewski Division of |

  6. 10 CFR 830 Major Modification Determination for Advanced Test Reactor LEU Fuel Conversion

    SciTech Connect (OSTI)

    Boyd D. Christensen; Michael A. Lehto; Noel R. Duckwitz

    2012-05-01

    The Advanced Test Reactor (ATR), located in the ATR Complex of the Idaho National Laboratory (INL), was constructed in the 1960s for the purpose of irradiating reactor fuels and materials. Other irradiation services, such as radioisotope production, are also performed at ATR. The ATR is fueled with high-enriched uranium (HEU) matrix (UAlx) in an aluminum sandwich plate cladding. The National Nuclear Security Administration Global Threat Reduction Initiative (GTRI) strategic mission includes efforts to reduce and protect vulnerable nuclear and radiological material at civilian sites around the world. Converting research reactors from using HEU to low-enriched uranium (LEU) was originally started in 1978 as the Reduced Enrichment for Research and Test Reactors (RERTR) Program under the U.S. Department of Energy (DOE) Office of Science. Within this strategic mission, GTRI has three goals that provide a comprehensive approach to achieving this mission: The first goal, the driver for the modification that is the subject of this determination, is to convert research reactors from using HEU to LEU. Thus the mission of the ATR LEU Fuel Conversion Project is to convert the ATR and Advanced Test Reactor Critical facility (ATRC) (two of the six U.S. High-Performance Research Reactors [HPRR]) to LEU fuel by 2017. The major modification criteria evaluation of the project pre-conceptual design identified several issues that lead to the conclusion that the project is a major modification.

  7. Tuning electron transport through a single molecular junction by bridge modification

    SciTech Connect (OSTI)

    Li, Xiao-Fei Qiu, Qi; Luo, Yi

    2014-07-07

    The possibility of controlling electron transport in a single molecular junction represents the ultimate goal of molecular electronics. Here, we report that the modification of bridging group makes it possible to improve the performance and obtain new functions in a single cross-conjugated molecular junction, designed from a recently synthesized bipolar molecule bithiophene naphthalene diimide. Our first principles results show that the bipolar characteristic remains after the molecule was modified and sandwiched between two metal electrodes. Rectifying is the intrinsic characteristic of the molecular junction and its performance can be enhanced by replacing the saturated bridging group with an unsaturated group. A further improvement of the rectifying and a robust negative differential resistance (NDR) behavior can be achieved by the modification of unsaturated bridge. It is revealed that the modification can induce a deviation angle about 4° between the donor and the acceptor π-conjugations, making it possible to enhance the communication between the two π systems. Meanwhile, the low energy frontier orbitals of the junction can move close to the Fermi level and encounter in energy at certain biases, thus a transport channel with a considerable transmission can be formed near the Fermi level only at a narrow bias regime, resulting in the improvement of rectifying and the robust NDR behavior. This finding could be useful for the design of single molecular devices.

  8. Liquid phase methanol LaPorte process development unit: Modification, operation, and support studies

    SciTech Connect (OSTI)

    Not Available

    1990-10-23

    The objectives of this program are to implement and test the process improvements identified through the engineering studies of the current program to demonstrate the capability of long-term catalyst activity maintenance, and to perform process and design engineering work that can be applied to a scaled-up Liquid Phase Methanol (LPMEOH) facility. An optional series of PDU runs is offered to extend the testing of the process improvements. A parallel research program will be performed to enhance the LPMEOH technical data base to improve the likelihood of commercialization of the LPMEOH process. Activities this quarter include: Flow sheet development for La Porte PDU modifications continues. A preliminary P ID review was completed and flow sheet modifications were identified and are being incorporated. A preliminary hazards review was completed on 22 May. Some minor flow sheet modifications resulted and a number of action items were identified. The most significant action item is to develop a materials reactivity and compatibility grid for the different alcohols, ethers, and esters which will be produced at the PDU. Heat and material balances were completed for the maximum production case of the mixed DME/MEOH synthesis campaign. An improved rate expression was developed. 1 fig.

  9. Plasma control by modification of helicon wave propagation in low magnetic fields

    SciTech Connect (OSTI)

    Lafleur, T.; Charles, C.; Boswell, R. W.

    2010-07-15

    By making use of nonuniform magnetic fields, it is shown experimentally that control of helicon wave propagation can be achieved in a low pressure (0.08 Pa) expanding plasma. The m=1 helicon waves are formed during a direct capacitive to wave mode transition that occurs in a low diverging magnetic field (B{sub 0}<3 mT). In this initial configuration, waves are prevented from reaching the downstream region, but slight modifications to the magnetic field allows the axial distance over which waves can propagate to be controlled. By changing the effective propagation distance in this way, significant modification of the density and plasma potential profiles can be achieved, showing that the rf power deposition can be spatially controlled as well. Critical to the modification of the wave propagation behavior is the magnetic field strength (and geometry) near the exit of the plasma source region, which gives electron cyclotron frequencies close to the wave frequency of 13.56 MHz.

  10. Effects of Surface Modification Conditions on Hydrophobicity of Silica-based Coating Additives

    SciTech Connect (OSTI)

    Armstrong, Beth L; Pawel, Steven J; Hunter, Scott Robert; Haynes, James A; Hillesheim, Daniel A

    2013-01-01

    Superhydrophobic silica (SHS) powders are being evaluated as a potential additive to the polyurethane topcoats used in Chemical Agent Resistant Coating (CARC) systems, with the goal of improving water repellency and corrosion protection characteristics. The current generation of CARC topcoats is already highly loaded with solids, and thus there is a premium on minimization of the total SHS powder required to achieve the desired properties. Therefore, efficient surface modification of the silica and proper dispersion in the coating will be required. The effect of a dispersant on the surface modification of silica particles by chlorosilanes was addressed in this study. The properties of various SHS powders were characterized by thermogravimetric analysis and mass spectroscopy. Correlations between powder modification conditions and the ultimate effects of the modified particles on hydrophobicity of CARC topcoats were assessed. The use of contact and rolling angle measurements along with scanning electron microscopy are discussed as they pertain to the ability to quantify the effects of modified silicas on corrosion prevention coatings. Furthermore, a systematic approach to modifying and testing both powders and top coats of corrosion prevention systems is presented.

  11. Human Factors Aspects of Operating Small Reactors

    SciTech Connect (OSTI)

    OHara, J.M.; Higgins, J.; Deem, R.; Xing, J.; DAgostino, A.

    2010-11-07

    The nuclear-power community has reached the stage of proposing advanced reactor designs to support power generation for decades to come. They are considering small modular reactors (SMRs) as one approach to meet these energy needs. While the power output of individual reactor modules is relatively small, they can be grouped to produce reactor sites with different outputs. Also, they can be designed to generate hydrogen, or to process heat. Many characteristics of SMRs are quite different from those of current plants, and so may require a concept of operations (ConOps) that also is different. The U.S. Nuclear Regulatory Commission (NRC) has begun examining the human factors engineering- (HFE) and ConOps- aspects of SMRs; if needed, they will formulate guidance to support SMR licensing reviews. We developed a ConOps model, consisting of the following dimensions: Plant mission; roles and responsibilities of all agents; staffing, qualifications, and training; management of normal operations; management of off-normal conditions and emergencies; and, management of maintenance and modifications. We are reviewing information on SMR design to obtain data about each of these dimensions, and have identified several preliminary issues. In addition, we are obtaining operations-related information from other types of multi-module systems, such as refineries, to identify lessons learned from their experience. Here, we describe the project's methodology and our preliminary findings.

  12. ETA-UTP009 - Measurement and Evaluation of Magnetic Fields (EMF...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Three Speed Test 6.5 Measurement of Electromagnetic Radiation 6.6 Determination of Radio ... This procedure shall collect test data as specified in the requirement of this procedure. ...

  13. Anthrax Lethal Factor

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Thiang Yian Wong, Robert Schwarzenbacher and Robert C. Liddington The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037. Anthrax Toxin is a major virulence factor in the infectious disease, Anthrax1. This toxin is produced by Bacillus anthracis, which is an encapsulated, spore-forming, rod-shaped bacterium. Inhalation anthrax, the most deadly form, is contracted through breathing spores. Once spores germinate within cells of the immune system called macrophages2, bacterial

  14. The MX Factor

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MX Factor Test films played a strategic-planning role in the debates of the late 1970s and early 1980s about where and how to deploy the MX intercontinental ballistic missile (LGM-118 Peacekeeper). The deployment would have to ensure that the missiles could survive a first strike by an adversary. Military planners were considering placing the missiles in clusters of hardened concrete shelters in the hot, dry Great Basin Desert of Nevada and Utah. Films of atmospheric tests at the Nevada Test

  15. WTP Contract Section F Contract No. DE-AC27-01RV14136 Conformed Thru Modification No. A143

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    F Contract No. DE-AC27-01RV14136 Conformed Thru Modification No. A143 F - i SECTION F DELIVERIES OR PERFORMANCE WTP Contract Section F Contract No. DE-AC27-01RV14136 Conformed Thru Modification No. A143 F - ii SECTION F DELIVERIES OR PERFORMANCE TABLE OF CONTENTS Section Clause Page F.1 PERIOD OF PERFORMANCE AND DELIVERY DATES ................................................................ 1 F.2 PRINCIPAL PLACE OF PERFORMANCE

  16. Modification of Mg{sub 2}Si in Mg–Si alloys with gadolinium

    SciTech Connect (OSTI)

    Ye, Lingying; Hu, Jilong Tang, Changping; Zhang, Xinming; Deng, Yunlai; Liu, Zhaoyang; Zhou, Zhile

    2013-05-15

    The modification effect of gadolinium (Gd) on Mg{sub 2}Si in the hypereutectic Mg–3 wt.% Si alloy has been investigated using optical microscope, scanning electron microscope, X-ray diffraction and hardness measurements. The results indicate that the morphology of the primary Mg{sub 2}Si is changed from coarse dendrite into fine polygon with the increasing Gd content. The average size of the primary Mg{sub 2}Si significantly decreases with increasing Gd content up to 1.0 wt.%, and then slowly increases. Interestingly, when the Gd content is increased to 4.0 and 8.0 wt.%, the primary and eutectic Mg{sub 2}Si evidently decrease and even disappear. The modification and refinement of the primary Mg{sub 2}Si is mainly attributed to the poisoning effect. The GdMg{sub 2} phase in the primary Mg{sub 2}Si is obviously coarsened as the Gd content exceeds 2.0 wt.%. While the decrease and disappearance of the primary and eutectic Mg{sub 2}Si are ascribed to the formation of vast GdSi compound. Therefore, it is reasonable to conclude that proper Gd (1.0 wt.%) addition can effectively modify and refine the primary Mg{sub 2}Si. - Highlights: ► Proper Gd (1.0 wt.%) addition can effectively modify and refine the primary Mg{sub 2}Si. ► We studied the reaction feasibility between Mg and Si, Gd and Si in Mg–Gd–Si system. ► We explored the modification mechanism of Gd modifier on Mg{sub 2}Si.

  17. 10 CFR 830 Major Modification Determination for Emergency Firewater Injection System Replacement

    SciTech Connect (OSTI)

    Noel Duckwitz

    2011-05-01

    The continued safe and reliable operation of the ATR is critical to the Department of Energy (DOE) Office of Nuclear Energy (NE) mission. While ATR is safely fulfilling current mission requirements, a variety of aging and obsolescence issues challenge ATR engineering and maintenance personnel’s capability to sustain ATR over the long term. First documented in a series of independent assessments, beginning with an OA Environmental Safety and Health Assessment conducted in 2003, the issues were validated in a detailed Material Condition Assessment (MCA) conducted as a part of the ATR Life Extension Program in 2007.Accordingly, near term replacement of aging and obsolescent original ATR equipment has become important to ensure ATR capability in support of NE’s long term national missions. To that end, a mission needs statement has been prepared for a non-major system acquisition which is comprised of three interdependent sub-projects. The first project will replace the existent diesel-electrical bus (E-3), switchgear, and the fifty year old antiquated marine diesels with commercial power that is backed with safety-related emergency diesel generators (EDGs), switchgear, and uninterruptible power supply. The second project will replace the four, obsolete, original primary coolant pumps and motors. The third project, the subject of this major modification determination, will replace the current emergency firewater injection system (EFIS). The replacement water injection system will function as the primary emergency water injection system with the EFIS being retained as a defense-in-depth backup. Completion of this and the two other age-related projects (replacement of the ATR diesel bus (E-3) and switchgear and replacement of the existent aged primary coolant pumps and motors) will resolve major age-related operational issues plus make a significant contribution in sustaining the ATR safety and reliability profile. The major modification criteria evaluation of the

  18. 10 CFR 830 Major Modification Determination for Advanced Test Reactor RDAS and LPCIS Replacement

    SciTech Connect (OSTI)

    David E. Korns

    2012-05-01

    The replacement of the ATR Control Complex's obsolete computer based Reactor Data Acquisition System (RDAS) and its safety-related Lobe Power Calculation and Indication System (LPCIS) software application is vitally important to ensure the ATR remains available to support this national mission. The RDAS supports safe operation of the reactor by providing 'real-time' plant status information (indications and alarms) for use by the reactor operators via the Console Display System (CDS). The RDAS is a computer support system that acquires analog and digital information from various reactor and reactor support systems. The RDAS information is used to display quadrant and lobe powers via a display interface more user friendly than that provided by the recorders and the Control Room upright panels. RDAS provides input to the Nuclear Engineering ATR Surveillance Data System (ASUDAS) for fuel burn-up analysis and the production of cycle data for experiment sponsors and the generation of the Core Safety Assurance Package (CSAP). RDAS also archives and provides for retrieval of historical plant data which may be used for event reconstruction, data analysis, training and safety analysis. The RDAS, LPCIS and ASUDAS need to be replaced with state-of-the-art technology in order to eliminate problems of aged computer systems, and difficulty in obtaining software upgrades, spare parts, and technical support. The major modification criteria evaluation of the project design did not lead to the conclusion that the project is a major modification. The negative major modification determination is driven by the fact that the project requires a one-for-one equivalent replacement of existing systems that protects and maintains functional and operational requirements as credited in the safety basis.

  19. Mining proteomic data to expose protein modifications in Methanosarcina mazei strain Gö1

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Leon, Deborah R.; Ytterberg, A. Jimmy; Boontheung, Pinmanee; Kim, Unmi; Loo, Joseph A.; Gunsalus, Robert P.; Ogorzalek Loo, Rachel R.

    2015-03-05

    Proteomic tools identify constituents of complex mixtures, often delivering long lists of identified proteins. The high-throughput methods excel at matching tandem mass spectrometry data to spectra predicted from sequence databases. Unassigned mass spectra are ignored, but could, in principle, provide valuable information on unanticipated modifications and improve protein annotations while consuming limited quantities of material. Strategies to “mine” information from these discards are presented, along with discussion of features that, when present, provide strong support for modifications. In this study we mined LC-MS/MS datasets of proteolytically-digested concanavalin A pull down fractions from Methanosarcina mazei Gö1 cell lysates. Analyses identified 154more » proteins. Many of the observed proteins displayed post-translationally modified forms, including O-formylated and methyl-esterified segments that appear biologically relevant (i.e., not artifacts of sample handling). Interesting cleavages and modifications (e.g., S-cyanylation and trimethylation) were observed near catalytic sites of methanogenesis enzymes. Of 31 Methanosarcina protein N-termini recovered by concanavalin A binding or from a previous study, only M. mazei S-layer protein MM1976 and its M. acetivorans C2A orthologue, MA0829, underwent signal peptide excision. Experimental results contrast with predictions from algorithms SignalP 3.0 and Exprot, which were found to over-predict the presence of signal peptides. Proteins MM0002, MM0716, MM1364, and MM1976 were found to be glycosylated, and employing chromatography tailored specifically for glycopeptides will likely reveal more. This study supplements limited, existing experimental datasets of mature archaeal N-termini, including presence or absence of signal peptides, translation initiation sites, and other processing. Methanosarcina surface and membrane proteins are richly modified.« less

  20. Mining proteomic data to expose protein modifications in Methanosarcina mazei strain Gö1

    SciTech Connect (OSTI)

    Leon, Deborah R.; Ytterberg, A. Jimmy; Boontheung, Pinmanee; Kim, Unmi; Loo, Joseph A.; Gunsalus, Robert P.; Ogorzalek Loo, Rachel R.

    2015-03-05

    Proteomic tools identify constituents of complex mixtures, often delivering long lists of identified proteins. The high-throughput methods excel at matching tandem mass spectrometry data to spectra predicted from sequence databases. Unassigned mass spectra are ignored, but could, in principle, provide valuable information on unanticipated modifications and improve protein annotations while consuming limited quantities of material. Strategies to “mine” information from these discards are presented, along with discussion of features that, when present, provide strong support for modifications. In this study we mined LC-MS/MS datasets of proteolytically-digested concanavalin A pull down fractions from Methanosarcina mazei Gö1 cell lysates. Analyses identified 154 proteins. Many of the observed proteins displayed post-translationally modified forms, including O-formylated and methyl-esterified segments that appear biologically relevant (i.e., not artifacts of sample handling). Interesting cleavages and modifications (e.g., S-cyanylation and trimethylation) were observed near catalytic sites of methanogenesis enzymes. Of 31 Methanosarcina protein N-termini recovered by concanavalin A binding or from a previous study, only M. mazei S-layer protein MM1976 and its M. acetivorans C2A orthologue, MA0829, underwent signal peptide excision. Experimental results contrast with predictions from algorithms SignalP 3.0 and Exprot, which were found to over-predict the presence of signal peptides. Proteins MM0002, MM0716, MM1364, and MM1976 were found to be glycosylated, and employing chromatography tailored specifically for glycopeptides will likely reveal more. This study supplements limited, existing experimental datasets of mature archaeal N-termini, including presence or absence of signal peptides, translation initiation sites, and other processing. Methanosarcina surface and membrane proteins are richly

  1. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1. CONTRACT ID CODE

    National Nuclear Security Administration (NNSA)

    l PAGE 1 OF 3PAGES 2. AMENDMENT/MODIFICATION NO. I 3. EFFECTIVE DATE 4. REQUISITION/PURCHASE REQ. NO. I 5. PROJECT NO. (If applicable) 180 See Block 16 C 6.1SSUEDBY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy National Nuclear Security Administration Manager, Los Alamos Site Office 3747 West Jemez Road Los Alamos, NM 87544 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, state, ZIP Code) 9A. AMENDMENT OF SOLICITATION NO. Los Alamos National Security, LLC

  2. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1. CONTRACT ID CODE

    National Nuclear Security Administration (NNSA)

    I PAGE 1 OF 1 PAGES 2. AMENDMENT/MODIFICATION NO. I 3. EFFECTIVE DATE 4. REQUISITION/PURCHASE REO. NO. I 5. PROJECT NO. (If applicable) 212 See Block 16 C 6.1SSUEDBY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy National Nuclear Security Administration Manager, Los Alamos Site Office 3747 West Jemez Road Los Alamos, NM 87544 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county. state, ZIP Code} 9A. AMENDMENT OF SOLICITATION NO. Los Alamos National Security, LLC

  3. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 11. CONTRACT ID CODE

    National Nuclear Security Administration (NNSA)

    I PAGE OF PAGES 1 I 2 2. AMENDMENT/MODIFICATION NO. 3. EFFECTIVE DATE 4. REQUISITION/PURCHASE REQ. NO. 15. PROJECT NO. (ff applicable) 0259 See Block 16C 6. ISSUED BY CODE 05003 7. ADMINISTERED BY (If other than Item 6) coDE 105003 NNSA/Los Alamos Site Office NNSA/Los Alamos Site Office u. s. Department of Energy u. s. Department of Energy NNSA/Los Alamos Site Office Los Alamos Site Off ice 3747 West Jemez Road 3747 West Jemez Road Los Alamos NM 87544 Los Alamos NM 87544 8. NAME AND ADDRESS OF

  4. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 11. CONTRACT ID CODE

    National Nuclear Security Administration (NNSA)

    l PAGE OF PAGES 1 I 3 2. AMENDMENT/MODIFICATION NO. See Block 16C 4. REQUISITION/PURCHASE REQ. NO. 15. PROJECT NO. (If applicable) 3. EFFECTIVE DA TE 0264 6. ISSUED BY CODE 05003 NNSA/Los Alamos Site Office U.S. Department of Energy NNSA/Los Alamos Site Office 3747 West Jemez Road Los Alamos NM 87544 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code) LOS ALAMOS NATIONAL SECURITY, LLC Attn: STEVE K. SHOOK P.O. BOX 1663, MS P222 LOS ALAMOS NM 875450001 CODE 175252894

  5. Microsoft Word - HABAdv#223_Life Cycle&TPA Modifications.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 Subject: Life Cycle Cost & Schedule Report of the Proposed Consent Decree & TPA Modifications Adopted: November 6, 2009 Page 1 November 6, 2009 Dave Brockman, Manager U.S. Department of Energy, Richland Operations P.O. Box 550 (A7-50) Richland, WA 99352 Shirley Olinger, Manager U.S. Department of Energy, Office of River Protection P.O. Box 450 (H6-60) Richland, WA 99352 Polly Zehm, Director Washington State Department of Ecology P.O. Box 47600 Olympia, WA 98504-7600 Michelle Pirzadeh,

  6. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1. 3OTATI OE AE O AE

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3OTATI OE AE O AE 2. AMENDMENT/MODIFICATION NO. 3. EFFECTIVE DATE (A't'VY) 4. REOUISITION/PURCHASE REQ. NO. 5. PROJECT NO. (If applicable) 199 See Block 16C N/A 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODE U.S. Department of Energy Office of River Protection P. 0. Box 450, MS 1-6-60 Rich land, WA 99352 8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP code) 9A. AMENDMENT OF SOLICITATION NO. Bechtel National, Inc. D 98. DATED (SEE ITEM 11) 2435 Stevens

  7. AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1.CONTRACT ID CODE PAGE OF PAGES

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    CONTRACT ID CODE PAGE OF PAGES T 1 1 13 2 AMENDIMENT/MODIFICATION NO 3. EFFECTIVE DATE 4 -REGUISITION/PURCHASE RED. NO 5. PROJECT NO. (If epplicable) 032 04/14/2011 11EM002244 6 ISSUED BY CODE 00603 7 ADMINISTERED BY (Iftherthan temrt6) CODE J00603 Office of River Protection Office of River Protection U.S. Department of Energy U.S. Department of Energy Office of River Protection office of River Protection P.O. Box 450 P.O. Box 450 Richland WA 99352 Richland WA 99352 8 NAME AND ADDRESS OF

  8. 11. CONTRACT ID CODE PAGE OF PAGES I AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

    National Nuclear Security Administration (NNSA)

    11. CONTRACT ID CODE PAGE OF PAGES I AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT 1 I 2. AMENDMENTIMODIFICATION NO. 258 6. ISSUED BY CODE 3. EFFECTIVE DATE See Block 16C 05008 4. REQUISITION/PURCHASE REQ. NO. 7. ADMINISTERED BY (If other than Item 6) 15. PROJECT NO. (If applicable) CODE 1 0 5 0 0 8 NNSA/Oakridge Site Office NNSA/Oakridge Site Office U.S. Department of Energy U. S. Department of Energy NNSA/Y-12 Site Office NNSA/Y-12 Site Office P.O. Box 2050 P.O. Box 2050 Building 9704-2

  9. Contract No. DE-AC02-07CH11358 Contract Modification No. 0192

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Contract Modification No. 0192 Section J Appendix H ATTACHMENT J.8 APPENDIX H SMALL BUSINESS SUBCONTRACTING PLAN Applicable to the Operation of AMES Laboratory Contract No. DE-AC02-07CH11358 'I'Hv. Ames Laboratory CtNrlng M*t*rl*l* & En*rgy So/utlotJI U ~ S, 0 £ J 1 A HT.M!NT C H' BNE UGY 2016 Subcontracting Plan Contractor: Ames Laboratory atlowa State Univers'ity (in eSRS a fowa State Equities Corporation) Address: 224 TASF, Ames IA 50011-3020 Solicitation or Contract Number: DE

  10. Contract No. DE-AC02-07CH11358 Contract Modification No. 0200

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Attachment J.5, Appendix E J-E-1 ATTACHMENT J.5 APPENDIX E AMES LABORATORY DEPARMENT OF ENERGY (LESSEE) INGRANTS Applicable to the Operation of AMES Laboratory Contract No. DE-AC02-07CH11358 Contract No. DE-AC02-07CH11358 Contract Modification No. 0200 Section J.5, Appendix E CONTRACT NO. BUILDING NAME(s) LESSOR CITY STATE PURPOSE COST EFFECT DATE EXP DATE ACRE DE-RL02-76CH00144* (formerly AT(11-1) 1309) Land Lease Construction Storage Shed Mechanical Maintenance Campus Warehouse Maintenance

  11. Contract No. DE-AC02-07CH11358 Contract Modification No. 0200

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Contract Modification No. 0200 Section H TOC i PART I SECTION H SPECIAL CONTRACT REQUIREMENTS TABLE OF CONTENTS CLAUSE NO. TITLE OF CLAUSE PAGE NO. H.1 LABORATORY FACILITIES H-1 H.2 LONG-RANGE PLANNING, PROGRAM DEVELOPMENT AND BUDGETARY ADMINISTRATION H-5 H.3 WORK PROGRAMS H-5 H.4 DEFENSE AND INDEMNIFICATION OF EMPLOYEES H-8 H.5 ADVANCE UNDERSTANDINGS REGARDING ADDITIONAL ITEMS OF ALLOWABLE AND UNALLOWABLE COSTS AND OTHER MATTERS H-9 H.6 FACILITIES CAPITAL COST OF MONEY H-10 H.7 ADMINISTRATION

  12. Contract No. DE-AC05-06OR23100, Modification A002

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Contract No. DE-AC04-94AL85000 Modification No. 473 Page 2 of 36 1. Section B, Clause B-2, Contract Type and Value is amended as follows: (i) Paragraph (b) is revised to add the total estimated cost entry under "Contract Periods" and "Estimated Cost" for FY 2013, changing the "TOTAL through" entry, and adding a place holder for the two option periods as follows: Add: October 1, 2012 through September 30, 2013 $ 2,462,698,305 Option 1: October 1, 2013 through $ TBD*

  13. Contract No. DE-AC06-97RL13184, Modification 158 Attachment J-4

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    6-97RL13184, Modification 158 Attachment J-4 Page 1 of 10 General Decision Number: WA130002 01/04/2013 WA2 Superseded General Decision Number: WA20120002 State: Washington Construction Types: Building, Heavy and Highway Counties: Benton and Franklin Counties in Washington. (D.O.E. HANFORD SITE ONLY) BENTON AND FRANKLIN COUNTIES (D.O.E. HANFORD SITE ONLY) BUILDING (does not include residential construction consisting of single family homes and apartments up to and including 4 stories), HEAVY and

  14. Contract No.: DE-AC02-07CH11358 Contract Modification No. 0159

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    : DE-AC02-07CH11358 Contract Modification No. 0159 Section J, Appendix C ATTACHMENT J.3 APPENDIX C SPECIAL FINANCIAL INSTITUTION ACCOUNT AGREEMENT Applicable to the Operation of AMES Laboratory Contract No. DE-AC02-07CH11358 AMENDMENT 8 TO SPECIAL FINANCIAL INSTITUTION ACCOUNT Page 1 of 2 AGREEMENT FOR USE WITH THE PAYMENTS CLEARED FINANCING ARRANGEMENT between BANKERS TRUST COMPANY, N.A. (hereinafter referred to as the "Financial Institution"), and IOWA STATE UNIVERSITY of Science and

  15. Contract Number DE-AC27-08RV14800 Continuation Page, Modification 360

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Number DE-AC27-08RV14800 Continuation Page, Modification 360 Page 2 of 4 The following changes are hereby incorporated into the contract under the authority of Federal Acquisition Regulation (FAR) 52.243-2 Changes-Cost Reimbursement, at no additional cost to the Government. 1. Update Contract Section H-15(f), Key Personnel for this Contract, to update the list as follows: FROM: Name Position Mr. Lyden David Olson TOC Project Manager Mr. Robert E. Wilkinson Manager, ESH&Q Mr. Doug Greenwell

  16. Nucleon Electromagnetic Form Factors

    SciTech Connect (OSTI)

    Marc Vanderhaeghen; Charles Perdrisat; Vina Punjabi

    2007-10-01

    There has been much activity in the measurement of the elastic electromagnetic proton and neutron form factors in the last decade, and the quality of the data has greatly improved by performing double polarization experiments, in comparison with previous unpolarized data. Here we review the experimental data base in view of the new results for the proton, and neutron, obtained at JLab, MAMI, and MIT-Bates. The rapid evolution of phenomenological models triggered by these high-precision experiments will be discussed, including the recent progress in the determination of the valence quark generalized parton distributions of the nucleon, as well as the steady rate of improvements made in the lattice QCD calculations.

  17. Laser engineered net shaping (LENS) for the repair and modification of NWC metal components.

    SciTech Connect (OSTI)

    Atwood, Clinton J.; Smugeresky, John E. (Sandia National Labs, Livermore,CA); Gill, David Dennis

    2006-11-01

    Laser Engineered Net Shaping{trademark} (LENS{reg_sign}) is a layer additive manufacturing process that creates fully dense metal components using a laser, metal powder, and a computer solid model. This process has previously been utilized in research settings to create metal components and new material alloys. The ''Qualification of LENS for the Repair and Modification of Metal NWC Components'' project team has completed a Technology Investment project to investigate the use of LENS for repair of high rigor components. The team submitted components from four NWC sites for repair or modification using the LENS process. These components were then evaluated for their compatibility to high rigor weapons applications. The repairs included hole filling, replacement of weld lips, addition of step joints, and repair of surface flaws and gouges. The parts were evaluated for mechanical properties, corrosion resistance, weldability, and hydrogen compatibility. This document is a record of the LENS processing of each of these component types and includes process parameters, build strategies, and lessons learned. Through this project, the LENS process was shown to successfully repair or modify metal NWC components.

  18. Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions

    SciTech Connect (OSTI)

    A Ruthenburg; H Li; T Milne; S Dewell; R McGinty; M Yuen; B Ueberheide; Y Dou; T Muir; et al.

    2011-12-31

    Little is known about how combinations of histone marks are interpreted at the level of nucleosomes. The second PHD finger of human BPTF is known to specifically recognize histone H3 when methylated on lysine 4 (H3K4me2/3). Here, we examine how additional heterotypic modifications influence BPTF binding. Using peptide surrogates, three acetyllysine ligands are indentified for a PHD-adjacent bromodomain in BPTF via systematic screening and biophysical characterization. Although the bromodomain displays limited discrimination among the three possible acetyllysines at the peptide level, marked selectivity is observed for only one of these sites, H4K16ac, in combination with H3K4me3 at the mononucleosome level. In support, these two histone marks constitute a unique trans-histone modification pattern that unambiguously resides within a single nucleosomal unit in human cells, and this module colocalizes with these marks in the genome. Together, our data call attention to nucleosomal patterning of covalent marks in dictating critical chromatin associations.

  19. Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions

    SciTech Connect (OSTI)

    Ruthenburg, Alexander J.; Li, Haitao; Milne, Thomas A.; Dewell, Scott; McGinty, Robert K.; Yuen, Melanie; Ueberheide, Beatrix; Dou, Yali; Muir, Tom W.; Patel, Dinshaw J.; Allis, C. David

    2011-09-20

    Little is known about how combinations of histone marks are interpreted at the level of nucleosomes. The second PHD finger of human BPTF is known to specifically recognize histone H3 when methylated on lysine 4 (H3K4me2/3). Here, we examine how additional heterotypic modifications influence BPTF binding. Using peptide surrogates, three acetyllysine ligands are indentified for a PHD-adjacent bromodomain in BPTF via systematic screening and biophysical characterization. Although the bromodomain displays limited discrimination among the three possible acetyllysines at the peptide level, marked selectivity is observed for only one of these sites, H4K16ac, in combination with H3K4me3 at the mononucleosome level. In support, these two histone marks constitute a unique trans-histone modification pattern that unambiguously resides within a single nucleosomal unit in human cells, and this module colocalizes with these marks in the genome. Together, our data call attention to nucleosomal patterning of covalent marks in dictating critical chromatin associations.

  20. Enhancing the Properties of Carbon and Gold Substrates by Surface Modification

    SciTech Connect (OSTI)

    Jennifer Anne Harnisch

    2002-06-27

    The properties of both carbon and gold substrates are easily affected by the judicious choice of a surface modification protocol. Several such processes for altering surface composition have been published in literature. The research presented in this thesis primarily focuses on the development of on-column methods to modify carbon stationary phases used in electrochemically modulated liquid chromatography (EMLC). To this end, both porous graphitic carbon (PGC) and glassy carbon (GC) particles have been modified on-column by the electroreduction of arenediazonium salts and the oxidation of arylacetate anions (the Kolbe reaction). Once modified, the carbon stationary phases show enhanced chromatographic performance both in conventional liquid chromatographic columns and EMLC columns. Additionally, one may also exploit the creation of aryl films to by electroreduction of arenediazonium salts in the creation of nanostructured materials. The formation of mercaptobenzene film on the surface of a GC electrode provides a linking platform for the chemisorption of gold nanoparticles. After deposition of nanoparticles, the surface chemistry of the gold can be further altered by self-assembled monolayer (SAM) formation via the chemisorption of a second thiol species. Finally, the properties of gold films can be altered such that they display carbon-like behavior through the formation of benzenehexathiol (BHT) SAMs. BHT chemisorbs to the gold surface in a previously unprecedented planar fashion. Carbon and gold substrates can be chemically altered by several methodologies resulting in new surface properties. The development of modification protocols and their application in the analytical arena is considered herein.

  1. Synthesis of visible light-activated TiO{sub 2} photocatalyst via surface organic modification

    SciTech Connect (OSTI)

    Jiang Dong Xu Yao Hou Bo; Wu Dong; Sun Yuhan

    2007-05-15

    A visible light-activated TiO{sub 2} photocatalyst was successfully synthesized by the surface organic modification to sol-gel-hydrothermal synthesized TiO{sub 2}. The surface hydroxyls of TiO{sub 2} nanoparticles reacted with the active -NCO groups of tolylene diisocyanate (TDI) to form a surface complex that was confirmed by the FT-IR and XPS spectra. Due to the existence of surface complex, the absorption edge of as-prepared TDI-modified TiO{sub 2} nanomaterial extended well into visible region. Compared with unmodified TiO{sub 2} and Degussa P25, the TDI-modified TiO{sub 2} photocatalysts showed higher activity for the photocatalytic degradation of methylene blue under visible light irradiation. - Graphical abstract: A visible light-activated TiO{sub 2} photocatalyst was successfully synthesized by the surface organic modification to TiO{sub 2}. The surface hydroxyls of TiO{sub 2} nanoparticles reacted with the active -NCO groups of tolylene diisocyanate (TDI) to form a surface complex. The TDI-modified TiO{sub 2} photocatalysts showed higher activity for the photocatalytic degradation of methylene blue under visible light irradiation.

  2. Modifications to WRFs dynamical core to improve the treatment of moisture for large-eddy simulations

    SciTech Connect (OSTI)

    Xiao, Heng; Endo, Satoshi; Wong, May; Skamarock, William C.; Klemp, Joseph B.; Fast, Jerome D.; Gustafson, Jr., William I.; Vogelmann, Andrew; Wang, Hailong; Liu, Yangang; Lin, Wuyin

    2015-10-29

    Yamaguchi and Feingold (2012) note that the cloud fields in their large-eddy simulations (LESs) of marine stratocumulus using the Weather Research and Forecasting (WRF) model exhibit a strong sensitivity to time stepping choices. In this study, we reproduce and analyze this sensitivity issue using two stratocumulus cases, one marine and one continental. Results show that (1) the sensitivity is associated with spurious motions near the moisture jump between the boundary layer and the free atmosphere, and (2) these spurious motions appear to arise from neglecting small variations in water vapor mixing ratio (qv) in the pressure gradient calculation in the acoustic sub-stepping portion of the integration procedure. We show that this issue is remedied in the WRF dynamical core by replacing the prognostic equation for the potential temperature θ with one for the moist potential temperature θm=θ(1+1.61qv), which allows consistent treatment of moisture in the calculation of pressure during the acoustic sub-steps. With this modification, the spurious motions and the sensitivity to the time stepping settings (i.e., the dynamic time step length and number of acoustic sub-steps) are eliminated in both of the example stratocumulus cases. In conclusion, this modification improves the applicability of WRF for LES applications, and possibly other models using similar dynamical core formulations, and also permits the use of longer time steps than in the original code.

  3. Design change documentation for the National Coal Model. [Mathematical model modifications

    SciTech Connect (OSTI)

    Not Available

    1980-05-14

    Several modifications are to be made to the National Coal Model (NCM) under contract number DE-AC01-79EI-10578. The model will be expanded to include two additional demand regions (increasing the total number of demand regions to 41) and one additional supply region (increasing the total number of supply regions to 31). Implementing this change in the NCM will be very simple. The relevant tables and lists will be expanded to include the new regions, and the dimensionality of all relevant arrays will be increased to 31 or 41, as required. A more difficult task will be to appropriately modify the various input data files to reflect the new regions. This task will be the responsibility of the Coal and Electric Power Analysis Division staff. The model will be modified to use externally-specified transportation rates for each origin/destination pair, rather than the linear transportation cost equations (based on mileage) that are used presently. Thus, an input file of transportation rates (prepared externally to the NCM, as are the coal supply curves) will be used directly to provide transportation rates ($/ton) for each coal type/origin/destination activity (i.e., column) generated in the transportation portion of the matrix generator. Other modifications under consideration relate to model output reports, an industrial boiler fuel model, and price-sensitive non-utility demand.

  4. Modifications to WRFs dynamical core to improve the treatment of moisture for large-eddy simulations

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Xiao, Heng; Endo, Satoshi; Wong, May; Skamarock, William C.; Klemp, Joseph B.; Fast, Jerome D.; Gustafson, Jr., William I.; Vogelmann, Andrew; Wang, Hailong; Liu, Yangang; et al

    2015-10-29

    Yamaguchi and Feingold (2012) note that the cloud fields in their large-eddy simulations (LESs) of marine stratocumulus using the Weather Research and Forecasting (WRF) model exhibit a strong sensitivity to time stepping choices. In this study, we reproduce and analyze this sensitivity issue using two stratocumulus cases, one marine and one continental. Results show that (1) the sensitivity is associated with spurious motions near the moisture jump between the boundary layer and the free atmosphere, and (2) these spurious motions appear to arise from neglecting small variations in water vapor mixing ratio (qv) in the pressure gradient calculation in themore » acoustic sub-stepping portion of the integration procedure. We show that this issue is remedied in the WRF dynamical core by replacing the prognostic equation for the potential temperature θ with one for the moist potential temperature θm=θ(1+1.61qv), which allows consistent treatment of moisture in the calculation of pressure during the acoustic sub-steps. With this modification, the spurious motions and the sensitivity to the time stepping settings (i.e., the dynamic time step length and number of acoustic sub-steps) are eliminated in both of the example stratocumulus cases. In conclusion, this modification improves the applicability of WRF for LES applications, and possibly other models using similar dynamical core formulations, and also permits the use of longer time steps than in the original code.« less

  5. Modifications to the cosmic 21-cm background frequency spectrum by scattering via electrons in galaxy clusters

    SciTech Connect (OSTI)

    Cooray, Asantha

    2006-05-15

    The cosmic 21-cm background frequency spectrum related to the spin-flip transition of neutral hydrogen present during and before the era of reionization is rich in features associated with physical processes that govern transitions between the two spin states. The intervening electrons in foreground galaxy clusters inversely Compton scatter the 21-cm background spectrum and modify it just as the cosmic microwave background (CMB) spectrum is modified by inverse-Compton scattering. Towards typical galaxy clusters at low redshifts, the resulting modification is a few tenths milli-Kelvin correction to the few tens milli-Kelvin temperature of 21-cm signal relative to that of the cosmic microwave background blackbody spectrum. The modifications are mostly associated with sharp changes in the cosmic 21-cm background spectrum such as due to the onset of a Lyman-{alpha} radiation field or heating of neutral gas. Though low-frequency radio interferometers that are now planned for 21-cm anisotropy measurements are insensitive to the mean 21-cm spectrum, differential observations of galaxy clusters with these interferometers can be utilized to indirectly establish global features in the 21-cm frequency spectrum. We discuss the feasibility to detect the spectrum modified by clusters and find that, for upcoming interferometers, while a detection towards an individual cluster is challenging, one can average signals over a number of clusters, selected based on the strength of the Sunyave-Zel'dovich effect at high radio frequencies involving CMB scattering alone, to establish the mean 21-cm spectrum.

  6. Characteristics RSE Column Factor: Total

    U.S. Energy Information Administration (EIA) Indexed Site

    and 1994 Vehicle Characteristics RSE Column Factor: Total 1993 Family Income Below Poverty Line Eli- gible for Fed- eral Assist- ance 1 RSE Row Factor: Less than 5,000 5,000...

  7. Polyamide desalination membrane characterization and surface modification to enhance fouling resistance.

    SciTech Connect (OSTI)

    Sharma, Mukul M.; Freeman, Benny D.; Van Wagner, Elizabeth M.; Hickner, Michael A.; Altman, Susan Jeanne

    2010-08-01

    The market for polyamide desalination membranes is expected to continue to grow during the coming decades. Purification of alternative water sources will also be necessary to meet growing water demands. Purification of produced water, a byproduct of oil and gas production, is of interest due to its dual potential to provide water for beneficial use as well as to reduce wastewater disposal costs. However, current polyamide membranes are prone to fouling, which decreases water flux and shortens membrane lifetime. This research explored surface modification using poly(ethylene glycol) diglycidyl ether (PEGDE) to improve the fouling resistance of commercial polyamide membranes. Characterization of commercial polyamide membrane performance was a necessary first step before undertaking surface modification studies. Membrane performance was found to be sensitive to crossflow testing conditions. Concentration polarization and feed pH strongly influenced NaCl rejection, and the use of continuous feed filtration led to higher water flux and lower NaCl rejection than was observed for similar tests performed using unfiltered feed. Two commercial polyamide membranes, including one reverse osmosis and one nanofiltration membrane, were modified by grafting PEGDE to their surfaces. Two different PEG molecular weights (200 and 1000) and treatment concentrations (1% (w/w) and 15% (w/w)) were studied. Water flux decreased and NaCl rejection increased with PEGDE graft density ({micro}g/cm{sup 2}), although the largest changes were observed for low PEGDE graft densities. Surface properties including hydrophilicity, roughness and charge were minimally affected by surface modification. The fouling resistance of modified and unmodified membranes was compared in crossflow filtration studies using model foulant solutions consisting of either a charged surfactant or an oil in water emulsion containing n-decane and a charged surfactant. Several PEGDE-modified membranes demonstrated improved

  8. Occupational Health Services Part I DE-AC06-04RL14383, Modification...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in the Performance Evaluation and Measurement Plan (PEMP) (see Section H.20). The contractor's performance relative to the PEMP will be considered as a factor in determining ...

  9. Human Factors Guidance for Control Room and Digital Human-System Interface Design and Modification, Guidelines for Planning, Specification, Design, Licensing, Implementation, Training, Operation and Maintenance

    SciTech Connect (OSTI)

    R. Fink, D. Hill, J. O'Hara

    2004-11-30

    Nuclear plant operators face a significant challenge designing and modifying control rooms. This report provides guidance on planning, designing, implementing and operating modernized control rooms and digital human-system interfaces.

  10. Structural modifications due to interface chemistry at metal-nitride interfaces

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Yadav, S. K.; Shao, S.; Wang, J.; Liu, X. -Y.

    2015-11-27

    Based on accurate first principles density functional theory (DFT) calculations, an unusual phenomenon of interfacial structural modifications, due to the interface chemistry influence is identified at two metal-nitride interfaces with strong metal-nitrogen affinity, Al/TiN {111} and Al/VN {111} interfaces. It is shown that at such interfaces, a faulted stacking structure is energetically preferred on the Al side of the interface. And both intrinsic and extrinsic stacking fault energies in the vicinity Al layers are negligibly small. However, such phenomenon does not occur in Pt/TiN and Pt/VN interfaces because of the weak Pt-N affinity. As a result, corresponding to structural energiesmore » of metal-nitride interfaces, the linear elasticity analysis predicts characteristics of interfacial misfit dislocations at metal-nitride interfaces.« less

  11. Structural modifications due to interface chemistry at metal-nitride interfaces

    SciTech Connect (OSTI)

    Yadav, S. K.; Shao, S.; Wang, J.; Liu, X. -Y.

    2015-11-27

    Based on accurate first principles density functional theory (DFT) calculations, an unusual phenomenon of interfacial structural modifications, due to the interface chemistry influence is identified at two metal-nitride interfaces with strong metal-nitrogen affinity, Al/TiN {111} and Al/VN {111} interfaces. It is shown that at such interfaces, a faulted stacking structure is energetically preferred on the Al side of the interface. And both intrinsic and extrinsic stacking fault energies in the vicinity Al layers are negligibly small. However, such phenomenon does not occur in Pt/TiN and Pt/VN interfaces because of the weak Pt-N affinity. As a result, corresponding to structural energies of metal-nitride interfaces, the linear elasticity analysis predicts characteristics of interfacial misfit dislocations at metal-nitride interfaces.

  12. Study on modification of the high-strength slag cement material

    SciTech Connect (OSTI)

    Wang Fusheng . E-mail: fusheng429@163.com; Sun Ruilian; Cui Yingjing

    2005-07-01

    The influence of the slag powder's fineness, the amounts of activator, type and contents of modification addition on the dry-shrinkage and strength of the high-strength slag cement material was investigated. The experimental data showed that adding 9% Na{sub 2}SiO{sub 3} activator and 10% Portland cement (PC) made the ratios of drying-shrinkage of high-strength slag cement material similar to the ratios of Portland cement and the compressive strengths as higher. The main hydration products are calcium alumina-silicate gels and a little CH; the gel ratio of CaO/SiO{sub 2} is close to 1 and includes a little Na{sub 2}O and MgO for high-strength slag cement material, as shown by means of scanning electron microscope (SEM) and energy-dispersive X-ray analyzer (EDXA)

  13. Modification of plasma flows with gas puff in the scrape-off layer of ADITYA tokamak

    SciTech Connect (OSTI)

    Sangwan, Deepak; Jha, Ratneshwar; Brotankova, Jana; Gopalkrishna, M. V. [Institute for Plasma Research, Gandhinagar 382428 (India)] [Institute for Plasma Research, Gandhinagar 382428 (India)

    2013-06-15

    The parallel Mach numbers are measured at three locations in the scrape-off layer (SOL) plasma of ADITYA tokamak by using Mach probes. The flow pattern is constructed from these measurements and the modification of flow pattern is observed by introducing a small puff of working gas. In the normal discharge, there is an indication of shell structure in the SOL plasma flows, which is removed during the gas puff. The plasma parameters, particle flux and Reynolds stress are also measured in the normal discharge and in the discharge with gas puff. It is observed that Reynolds stress and Mach number are coupled in the near SOL region and decoupled in the far SOL region. The coupling in the near SOL region gets washed away during the gas puff.

  14. Precision shape modification of nanodevices with a low-energy electron beam

    DOE Patents [OSTI]

    Zettl, Alex; Yuzvinsky, Thomas David; Fennimore, Adam

    2010-03-09

    Methods of shape modifying a nanodevice by contacting it with a low-energy focused electron beam are disclosed here. In one embodiment, a nanodevice may be permanently reformed to a different geometry through an application of a deforming force and a low-energy focused electron beam. With the addition of an assist gas, material may be removed from the nanodevice through application of the low-energy focused electron beam. The independent methods of shape modification and material removal may be used either individually or simultaneously. Precision cuts with accuracies as high as 10 nm may be achieved through the use of precision low-energy Scanning Electron Microscope scan beams. These methods may be used in an automated system to produce nanodevices of very precise dimensions. These methods may be used to produce nanodevices of carbon-based, silicon-based, or other compositions by varying the assist gas.

  15. Phosphonic Acid Functionalized Asymmetric Phthalocyanines: Synthesis, Modification of Indium Tin Oxide (ITO), and Charge Transfer

    SciTech Connect (OSTI)

    Polaske, Nathan W.; Lin, Hsiao-Chu; Tang, Anna; Mayukh, Mayank; Oquendo, Luis E.; Green, John; Ratcliff, Erin L.; Armstrong, Neal R.; Saavedra, S. Scott; McGrath, Dominic V.

    2011-12-20

    Metalated and free-base A?B-type asymmetric phthalocyanines (Pcs) bearing, in the asymmetric quadrant, a flexible alkyl linker of varying chain lengths terminating in a phosphonic acid (PA) group have been synthesized. Two parallel series of asymmetric Pc derivatives bearing aryloxy and arylthio substituents are reported, and their synthesis and characterization through NMR, combustion analysis, and MALDI-MS are described. We also demonstrate the modification of indium tin oxide (ITO) substrates using the PA functionalized asymmetric Pc derivatives and monitoring their electrochemistry. The PA functionalized asymmetric Pcs were anchored to the ITO surface through chemisorption and their electrochemical properties characterized using cyclic voltammetry to investigate the effects of PA structure on the thermodynamics and kinetics of charge transfer. Ionization energies of the modified ITO surfaces were measured using ultraviolet photoemission spectroscopy.

  16. Origin of mechanical modifications in poly (ether ether ketone)/carbon nanotube composite

    SciTech Connect (OSTI)

    Pavlenko, Ekaterina; Puech, Pascal; Bacsa, Wolfgang; Boyer, François; Olivier, Philippe; Sapelkin, Andrei; King, Stephen; Heenan, Richard; Pons, François; Gauthier, Bénédicte; Cadaux, Pierre-Henri

    2014-06-21

    Variations in the hardness of a poly (ether ether ketone) beam electrically modified with multi-walled carbon nanotubes (MWCNT, 0.5%-3%) are investigated. It is shown that both rupture and hardness variations correlate with the changes in carbon nanotube concentration when using micro indentation and extended Raman imaging. Statistical analysis of the relative spectral intensities in the Raman image is used to estimate local tube concentration and polymer crystallinity. We show that the histogram of the Raman D band across the image provides information about the amount of MWCNTs and the dispersion of MWCNTs in the composite. We speculate that we have observed a local modification of the ordering between pure and modified polymer. This is partially supported by small angle neutron scattering measurements, which indicate that the agglomeration state of the MWCNTs is the same at the concentrations studied.

  17. Environmental assessment for operations, upgrades, and modifications in SNL/NM Technical Area IV

    SciTech Connect (OSTI)

    1996-04-01

    The proposed action for this EA for Sandia National Laboratories/New Mexico Technical Area IV, includes continuing existing operations, modification of an existing accelerator (Particle Beam Fusion Accelerator II) to support defnese-related Z-pinch experiments, and construction of two transformer oil storage tanks to support the expansion of the Advanced Pulsed Power Research Module, a single pulse accelerator. Based on the analyses in the EA, DOE believes that the proposed action is not a major federal action significantly affecting the quality of the human environment within the meaning of NEPA and CEQ NEPA implementing regulations in 40 CFR 1508.18 and 1508.27. Therefore, an environmental impact statement is not required, and a Finding of No Significant Impact is issued.

  18. A Halotyrosine Antibody that Detects Increased Protein Modifications in Asthma Patients

    SciTech Connect (OSTI)

    Jin, Hongjun; Hallstrand, Teal S.; Daly, Don S.; Matzke, Melissa M.; Nair, Parameswaran; Bigelow, Diana J.; Pounds, Joel G.; Zangar, Richard C.

    2014-01-31

    Background-Airway inflammation plays an important pathophysiological role in asthma. Eosinophils produce hypobromite and bromotyrosine while neutrophils produce hypochlorite and chlorotyrosine. Objective-To evaluate halotyrosine modifications of individual airway proteins as a marker of inflammation in asthma using an antibody-based assay. Methods-We developed a novel monoclonal antibody (BTK-94C) that binds halogenated tyrosine residues, and used this antibody in a custom enzyme-linked immunosorbent assay (ELISA) microarray platform to examine halotyrosine levels in 23 proteins in three independent sets of sputum samples (52 samples total). Results-In 15 subjects with either no asthma, or with asthma characterized by high or low sputum eosinophil counts, we found associations between increased halotyrosine levels of at least three proteins and severity of airway hyperresponsiveness (AHR). Treatment with mepolizumab in 17 patients with sputum eosinophilia markedly reduced the sputum eosinophilia and significantly reduced halotyrosine levels in one sputum protein. Further analysis of 10 subjects with neutrophilic asthma and 10 health controls demonstrated a broad increase in halotyrosine in the patients with airway neutrophilia. Conclusions-Significantly higher levels of halotyrosine are associated with asthma in the asthma phenotypes we examined. The halotyrosine levels correlated with indirect AHR in the form of exercise-induced bronchoconstriction. Clinical Implication-An antibody-based assay for tyrosine halogenation in specific proteins may prove useful for assessing airway inflammation in asthma. Capsule Summary-An antibody to measure protein monobrominated tyrosine and other halotyrosine modifications was developed and used to evaluate halogenation in specific proteins in the airways for the first time. Associations were found between levels of halotyrosine and exercise-induced bronchoconstriction, and eosinophil and neutrophil inflammation in sputum from

  19. Recrystallization and modification of the stainless-steel surface relief under photonic heat load in powerful plasma discharges

    SciTech Connect (OSTI)

    Budaev, V. P. Martynenko, Yu. V.; Khimchenko, L. N.; Zhitlukhin, A. M.; Klimov, N. S.; Pitts, R. A.; Linke, J.; Bazylev, B.; Belova, N. E.; Karpov, A. V.; Kovalenko, D. V.; Podkovyrov, V. L.; Yaroshevskaya, A. D.

    2013-11-15

    Targets made of ITER-grade 316L(N)-IG stainless steel and Russian-grade 12Cr18Ni10Ti stainless steel with a close composition were exposed at the QSPA-T plasma gun to plasma photonic radiation pulses simulating conditions of disruption mitigation in ITER. After a large number of pulses, modification of the stainless-steel surface was observed, such as the formation of a wavy structure, irregular roughness, and cracks on the target surface. X-ray and optic microscopic analyses of targets revealed changes in the orientation and dimensions of crystallites (grains) over a depth of up to 20 μm for 316L(N)-IG stainless steel after 200 pulses and up to 40 μm for 12Cr18Ni10Ti stainless steel after 50 pulses, which is significantly larger than the depth of the layer melted in one pulse (∼10 μm). In a series of 200 tests of ITER-grade 316L(N)-IG ITER stainless steel, a linear increase in the height of irregularity (roughness) with increasing number of pulses at a rate of up to ∼1 μm per pulse was observed. No alteration in the chemical composition of the stainless-steel surface in the series of tests was revealed. A model is developed that describes the formation of wavy irregularities on the melted metal surface with allowance for the nonlinear stage of instability of the melted layer with a vapor/plasma flow above it. A decisive factor in this case is the viscous flow of the melted metal from the troughs to tops of the wavy structure. The model predicts saturation of the growth of the wavy structure when its amplitude becomes comparable with its wavelength. Approaches to describing the observed stochastic relief and roughness of the stainless-steel surface formed in the series of tests are considered. The recurrence of the melting-solidification process in which mechanisms of the hill growth compete with the spreading of the material from the hills can result in the formation of a stochastic relief.

  20. 1. CONTRACT ID CODE PAGE of: PAGES AMENDM ENT OF SOLICITATION/MODIFICATION OF CONTRACT I -1 5

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of: PAGES AMENDM ENT OF SOLICITATION/MODIFICATION OF CONTRACT I -1 5 2. AMENDMENT/MODIFICATION NO. 3. EFFECTIVE DATE (0/1T 4. REQUISITION/PURCHASE REQ. NO. 5. PROJECT NO. (If applicable) 286 See Block 16C 12EM0014771 6. ISSUED BY CODE 7. AD)MINISTERED BY (If otherrtianItm 6) CODE U.S. Department of Energy Office of River Protection P. 0. Box 450, MIS 116-60 Richland, WA 99352 8. NAME AND ADDRESS OF CONTRACTOR (No., street. county.. State and ZIP code) 9A. AMENDMENT OF SOLICITATION NO. Bechtel

  1. Plateau Remediation Contract Section J Contract No. DE-AC06-08RL14788 Modification No. 439

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    No. 439 J 4-1 August 31, 2015 ATTACHMENT J.4 PERFORMANCE EVALUATION AND MEASUREMENT PLAN (PEMP) Plateau Remediation Contract Section J Contract No. DE-AC06-08RL14788 Modification No. 439 J 4-2 August 31, 2015 Fiscal Year 2016 Performance Evaluation and Measurement Plan For CH2MHill Plateau Remediation Company Performance Period: October 1, 2015, through September 30, 2016 Plateau Remediation Contract Section J Contract No. DE-AC06-08RL14788 Modification No. 439 J 4-3 August 31, 2015 TABLE OF

  2. Contract No. DE-AC02-07CH11358 Section J Appendix G Contract Modification No. 0183

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Section J Appendix G Contract Modification No. 0183 ATTACHMENT J.7 Contract No. DE-AC02-07CH11358 J-G-1 APPENDIX G PURCHASING SYSTEM REQUIREMENTS Applicable to the Operation of AMES Laboratory Contract No. DE-AC02-07CH11358 Section J Appendix G Contract Modification No. 0183 Appendix G Purchasing System Requirements This Appendix and Clause 1.154, "Contractor Purchasing System," sets forth DOE requirements applicable to the Purchasing System established under the Contract for the

  3. Likelihood-based modification of experimental crystal structure electron density maps

    DOE Patents [OSTI]

    Terwilliger, Thomas C.

    2005-04-16

    A maximum-likelihood method for improves an electron density map of an experimental crystal structure. A likelihood of a set of structure factors {F.sub.h } is formed for the experimental crystal structure as (1) the likelihood of having obtained an observed set of structure factors {F.sub.h.sup.OBS } if structure factor set {F.sub.h } was correct, and (2) the likelihood that an electron density map resulting from {F.sub.h } is consistent with selected prior knowledge about the experimental crystal structure. The set of structure factors {F.sub.h } is then adjusted to maximize the likelihood of {F.sub.h } for the experimental crystal structure. An improved electron density map is constructed with the maximized structure factors.

  4. Factors Affecting PMU Installation Costs

    Broader source: Energy.gov (indexed) [DOE]

    ... information to improve the modeling, forecasting and controls of the grid Standards ... Department of Energy |September 2014 Factors Affecting PMU Installation Costs | Page 3 ...

  5. Co-repressor activity of scaffold attachment factor B1 requires sumoylation

    SciTech Connect (OSTI)

    Garee, Jason P.; Meyer, Rene; Systems Biology of Signal Transduction, German Cancer Research Center , INF 280, 69120 Heidelberg ; Oesterreich, Steffi

    2011-05-20

    Highlights: {yields} SAFB1 is sumoylated to two lysine residues K231 and K294. {yields} SAFB1 sumoylation is regulated by PIAS1 and SENP1. {yields} Sumoylation of SAFB1 regulates its transcriptional repressor activity. {yields} Mutation of sumoylation sites leads to decreased SAFB1 binding to HDAC3. -- Abstract: Sumoylation is an emerging modification associated with a variety of cellular processes including the regulation of transcriptional activities of nuclear receptors and their coregulators. As SUMO modifications are often associated with transcriptional repression, we examined if sumoylation was involved in modulation of the transcriptional repressive activity of scaffold attachment factor B1. Here we show that SAFB1 is modified by both the SUMO1 and SUMO2/3 family of proteins, on lysine's K231 and K294. Further, we demonstrate that SAFB1 can interact with PIAS1, a SUMO E3 ligase which mediates SAFB1 sumoylation. Additionally, SENP1 was identified as the enzyme desumoylating SAFB1. Mutation of the SAFB1 sumoylation sites lead to a loss of transcriptional repression, at least in part due to decreased interaction with HDAC3, a known transcriptional repressor and SAFB1 binding partner. In summary, the transcriptional repressor SAFB1 is modified by both SUMO1 and SUMO2/3, and this modification is necessary for its full repressive activity.

  6. 10 CFR 830 Major Modification Determination for Replacement of ATR Primary Coolant Pumps and Motors

    SciTech Connect (OSTI)

    Noel Duckwitz

    2011-05-01

    The continued safe and reliable operation of the ATR is critical to the Department of Energy (DOE) Office of Nuclear Energy (NE) mission. While ATR is safely fulfilling current mission requirements, a variety of aging and obsolescence issues challenge ATR engineering and maintenance personnel’s capability to sustain ATR over the long term. First documented in a series of independent assessments, beginning with an OA Environmental Safety and Health Assessment conducted in 2003, the issues were validated in a detailed Material Condition Assessment (MCA) conducted as a part of the ATR Life Extension Program in 2007.Accordingly, near term replacement of aging and obsolescent original ATR equipment has become important to ensure ATR capability in support of NE’s long term national missions. To that end, a mission needs statement has been prepared for a non-major system acquisition which is comprised of three interdependent subprojects. The first project will replace the existent diesel-electrical bus (E-3), switchgear, and the 50-year-old obsolescent marine diesels with commercial power that is backed with safety related emergency diesel generators, switchgear, and uninterruptible power supply (UPS). The second project, the subject of this major modification determination, will replace the four, obsolete, original primary coolant pumps (PCPs) and motors. Completion of this and the two other age-related projects (replacement of the ATR diesel bus [E-3] and switchgear and replacement of the existent emergency firewater injection system) will resolve major age-related operational issues plus make a significant contribution in sustaining the ATR safety and reliability profile. The major modification criteria evaluation of the project pre-conceptual design identified several issues that lead to the conclusion that the project is a major modification: 1. Evaluation Criteria #3 (Change of existing process). The proposed strategy for equipping the replacement PCPs with VFDs

  7. Resin-assisted enrichment of thiols as a general strategy for proteomic profiling of cysteine-based reversible modifications

    SciTech Connect (OSTI)

    Guo, Jia; Gaffrey, Matthew J.; Su, Dian; Liu, Tao; Camp, David G.; Smith, Richard D.; Qian, Weijun

    2013-12-12

    Reversible modifications on cysteine thiols play a significant role in redox signaling and regulation. A number of reversible redox modifications, including disulfide formation, S-nitrosylation, and S-glutathionylation, have been recognized for their significance in various physiological and pathological processes. Here we describe in detail a resin-assisted thiol-affinity enrichment protocol for both biochemical and proteomics applications. This protocol serves as a general approach for specific isolation of thiol-containing proteins or peptides derived from reversible redox-modified proteins. This approach utilizes thiol-affinity resins to directly capture thiol-containing proteins or peptides through a disulfide exchange reaction followed by on-resin protein digestion and on-resin multiplexed isobaric labeling to facilitate LC-MS/MS based quantitative site-specific analysis of redox modifications. The overall approach requires a much simpler workflow with increased specificity compared to the commonly used biotin switch technique. By coupling different selective reduction strategies, the resin-assisted approach provides the researcher with a useful tool capable of enriching different types of reversible modifications on protein thiols. Procedures for selective enrichment and analyses of S-nitrosylation and total reversible cysteine oxidation are presented to demonstrate the utility of this general strategy.

  8. Mission Support Contract Attachment J.10 Contract No. DE-AC06-09RL14728 Modification 502

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Attachment J.10 Contract No. DE-AC06-09RL14728 Modification 502 Table of Contents J.10-1 SERVICE CONTRACT ACT: WAGE DETERMINATION ...................................................................... 2 J.10-2 DAVIS BACON ACT: GENERAL DECISION ..................................................................................... 22 J.10-3 COLLECTIVE BARGAINING ACT: WAGE DETERMINATION ........................................................... 33 Mission Support Contract Attachment J.10 Contract

  9. Factor CO2 | Open Energy Information

    Open Energy Info (EERE)

    Factor CO2 Jump to: navigation, search Name: Factor CO2 Place: Bilbao, Spain Zip: 48008 Product: Spain-based consultancy specializing in climate change projects. References: Factor...

  10. 10 CFR 830 Major Modification Determination for the ATR Diesel Bus (E-3) and Switchgear Replacement

    SciTech Connect (OSTI)

    Noel Duckwtiz

    2011-05-01

    Near term replacement of aging and obsolescent original ATR equipment has become important to ensure ATR capability in support of NE’s long term national missions. To that end, a mission needs statement has been prepared for a non-major system acquisition which is comprised of three interdependent subprojects. The first project, subject of this determination, will replace the existent diesel-electrical bus (E-3) and associated switchgear. More specifically, INL proposes transitioning ATR to 100% commercial power with appropriate emergency backup to include: • Provide commercial power as the normal source of power to the ATR loads currently supplied by diesel-electric power. • Provide backup power to the critical ATR loads in the event of a loss of commercial power. • Replace obsolescent critical ATR power distribution equipment, e.g., switchgear, transformers, motor control centers, distribution panels. Completion of this and two other age-related projects (primary coolant pump and motor replacement and emergency firewater injection system replacement) will resolve major age related operational issues plus make a significant contribution in sustaining the ATR safety and reliability profile. The major modification criteria evaluation of the project pre-conceptual design identified several issues make the project a major modification: 1. Evaluation Criteria #2 (Footprint change). The addition of a new PC-4 structure to the ATR Facility to house safety-related SSCs requires careful attention to maintaining adherence to applicable engineering and nuclear safety design criteria (e.g., structural qualification, fire suppression) to ensure no adverse impacts to the safety-related functions of the housed equipment. 2. Evaluation Criteria #3 (Change of existing process). The change to the strategy for providing continuous reliable power to the safety-related emergency coolant pumps requires careful attention and analysis to ensure it meets a project primary object

  11. Environmentally Benign and Permanent Modifications to Prevent Biofouling on Marine and Hydrokinetic Devices

    SciTech Connect (OSTI)

    Zheng Zhang

    2012-04-19

    Semprus Biosciences is developing environmentally benign and permanent modifications to prevent biofouling on Marine and Hydrokinetic (MHK) devices. Biofouling, including growth on external surfaces by bacteria, algae, barnacles, mussels, and other marine organisms, accumulate quickly on MHK devices, causing mechanical wear and changes in performance. Biofouling on crucial components of hydrokinetic devices, such as rotors, generators, and turbines, imposes substantial mass and hydrodynamic loading with associated efficiency loss and maintenance costs. Most antifouling coatings leach toxic ingredients, such as copper and tributyltin, through an eroding process, but increasingly stringent regulation of biocides has led to interest in the development of non-biocidal technologies to control fouling. Semprus Biosciences research team is developing modifications to prevent fouling from a broad spectrum of organisms on devices of all shapes, sizes, and materials for the life of the product. The research team designed and developed betaine-based polymers as novel underwater coatings to resist the attachment of marine organisms. Different betaine-based monomers and polymers were synthesized and incorporated within various coating formulations. The formulations and application methods were developed on aluminum panels with required adhesion strength and mechanical properties. The coating polymers were chemically stable under UV, hydrolytic and oxidative environments. The sulfobetaine formulations are applicable as nonleaching and stable underwater coatings. For the first time, coating formulations modified with highly packed sulfobetaine polymers were prepared and demonstrated resistance to a broad spectrum of marine organisms. Assays for comparing nonfouling performance were developed to evaluate protein adsorption and bacteria attachment. Barnacle settlement and removal were evaluated and a 60-day field test was performed. Silicone substrates including a commercial

  12. Advanced Natural Gas Reciprocating Engine: Parasitic Loss Control through Surface Modification

    SciTech Connect (OSTI)

    Farshid Sadeghi; Chin-Pei Wang

    2008-12-31

    This report presents results of our investigation on parasitic loss control through surface modification in reciprocating engine. In order to achieve the objectives several experimental and corresponding analytical models were designed and developed to corroborate our results. Four different test rigs were designed and developed to simulate the contact between the piston ring and cylinder liner (PRCL) contact. The Reciprocating Piston Test Rig (RPTR) is a novel suspended liner test apparatus which can be used to accurately measure the friction force and side load at the piston-cylinder interface. A mixed lubrication model for the complete ring-pack and piston skirt was developed to correlate with the experimental measurements. Comparisons between the experimental and analytical results showed good agreement. The results revealed that in the reciprocating engines higher friction occur near TDC and BDC of the stroke due to the extremely low piston speed resulting in boundary lubrication. A Small Engine Dynamometer Test Rig was also designed and developed to enable testing of cylinder liner under motored and fired conditions. Results of this study provide a baseline from which to measure the effect of surface modifications. The Pin on Disk Test Rig (POD) was used in a flat-on-flat configuration to study the friction effect of CNC machining circular pockets and laser micro-dimples. The results show that large and shallow circular pockets resulted in significant friction reduction. Deep circular pockets did not provide much load support. The Reciprocating Liner Test Rig (RLTR) was designed to simplifying the contact at the PRCL interface. Accurate measurement of friction was obtained using 3-axis piezoelectric force transducer. Two fiber optic sensors were used to measure the film thickness precisely. The results show that the friction force is reduced through the use of modified surfaces. The Shear Driven Test Rig (SDTR) was designed to simulate the mechanism of the

  13. Efficiency of plasma actuator ionization in shock wave modification in a rarefied supersonic flow over a flat plate

    SciTech Connect (OSTI)

    Joussot, Romain; Lago, Viviana; Parisse, Jean-Denis

    2014-12-09

    This paper describes experimental and numerical investigations focused on the shock wave modification, induced by a dc glow discharge, of a Mach 2 flow under rarefied regime. The model under investigation is a flat plate equipped with a plasma actuator composed of two electrodes. The glow discharge is generated by applying a negative potential to the upstream electrode, enabling the creation of a weakly ionized plasma. The natural flow (i.e. without the plasma) exhibits a thick laminar boundary layer and a shock wave with a hyperbolic shape. Images of the flow obtained with an ICCD camera revealed that the plasma discharge induces an increase in the shock wave angle. Thermal effects (volumetric, and at the surface) and plasma effects (ionization, and thermal non-equilibrium) are the most relevant processes explaining the observed modifications. The effect induced by the heating of the flat plate surface is studied experimentally by replacing the upstream electrode by a heating element, and numerically by modifying the thermal boundary condition of the model surface. The results show that for a similar temperature distribution over the plate surface, modifications induced by the heating element are lower than those produced by the plasma. This difference shows that other effects than purely thermal effects are involved with the plasma actuator. Measurements of the electron density with a Langmuir probe highlight the fact that the ionization degree plays an important role into the modification of the flow. The gas properties, especially the isentropic exponent, are indeed modified by the plasma above the actuator and upstream the flat plate. This leads to a local modification of the flow conditions, inducing an increase in the shock wave angle.

  14. Effects of laser fluence on silicon modification by four-beam laser interference

    SciTech Connect (OSTI)

    Zhao, Le; Li, Dayou; Wang, Zuobin Yue, Yong; Zhang, Jinjin; Yu, Miao; Li, Siwei

    2015-12-21

    This paper discusses the effects of laser fluence on silicon modification by four-beam laser interference. In this work, four-beam laser interference was used to pattern single crystal silicon wafers for the fabrication of surface structures, and the number of laser pulses was applied to the process in air. By controlling the parameters of laser irradiation, different shapes of silicon structures were fabricated. The results were obtained with the single laser fluence of 354 mJ/cm{sup 2}, 495 mJ/cm{sup 2}, and 637 mJ/cm{sup 2}, the pulse repetition rate of 10 Hz, the laser exposure pulses of 30, 100, and 300, the laser wavelength of 1064 nm, and the pulse duration of 7–9 ns. The effects of the heat transfer and the radiation of laser interference plasma on silicon wafer surfaces were investigated. The equations of heat flow and radiation effects of laser plasma of interfering patterns in a four-beam laser interference distribution were proposed to describe their impacts on silicon wafer surfaces. The experimental results have shown that the laser fluence has to be properly selected for the fabrication of well-defined surface structures in a four-beam laser interference process. Laser interference patterns can directly fabricate different shape structures for their corresponding applications.

  15. Surface modification of cellulose acetate membrane using thermal annealing to enhance produced water treatment

    SciTech Connect (OSTI)

    Kusworo, T. D. Aryanti, N. Firdaus, M. M. H.; Sukmawati, H.

    2015-12-29

    This study is performed primarily to investigate the effect of surface modification of cellulose acetate using thermal annealing on the enhancement of membrane performance for produced water treatment. In this study, Cellulose Acetate membranes were casted using dry/wet phase inversion technique. The effect of additive and post-treatment using thermal annealing on the membrane surface were examined for produced water treatment. Therma annealing was subjected to membrane surface at 60 and 70 °C for 5, 10 and 15 second, respectively. Membrane characterizations were done using membrane flux and rejection with produced water as a feed, Scanning Electron Microscopy (SEM) and Fourier Transform Infra Red (FTIR) analysis. Experimental results showed that asymmetric cellulose acetate membrane can be made by dry/wet phase inversion technique. The results from the Scanning Electron Microscopy (FESEM) analysis was also confirmed that polyethylene glycol as additivie in dope solution and thermal annealing was affected the morphology and membrane performance for produced water treatment, respectively. Scanning electron microscopy micrographs showed that the selective layer and the substructure of membrane became denser and more compact after the thermal annealing processes. Therefore, membrane rejection was significantly increased while the flux was slighty decreased, respectively. The best membrane performance is obtained on the composition of 18 wt % cellulose acetate, poly ethylene glycol 5 wt% with thermal annealing at 70° C for 15 second.

  16. Safety assessment document (SAD) for the Princeton Beta Experiment Modification (PBX-M)

    SciTech Connect (OSTI)

    Stencel, J.R.; Parsells, R.F.

    1988-04-01

    The Princeton Beta Experiment-Modification (PBX-M) is an experimental device of the tokamak type. A tokamak is characterized by a strong toroidal magnetic field composed of an externally driven component parallel to the torus centerline modified by the field produced by a transformer-driven current (OH) in the confined plasma. A second magnetic field parallel to the major toroidal axis is added to provide radial equilibrium for the plasma. As an advanced tokamak, PBX-M will have additional magnetic fields to reshape the plasma cross section from a circle into a kidney bean shape; it will also be equipped with 6MW or more of auxiliary heating power provided by four neutral beam injectors, with RF systems, and with an extensive set of diagnostics. Potential hazards associated with PBX-M, which are analyzed in this report, result from energy stored in the magnetic fields, high voltages necessary for the operation of some of the equipment and diagnostics, neutron radiation when the neutral beams are run with deuterium and x-rays, especially those emitted as a result of plasma-wall interaction. This report satisfies the requirements set forth in the PPPL Health and Safety Directives, specifically HSD-5003, and in DOE Order 5481.1B and its Chicago operations supplement (DOE86, DOE82).

  17. Independent design review report for truck {number_sign}1 modifications for flammable gas tanks

    SciTech Connect (OSTI)

    Wilson, G.W.

    1997-05-09

    The East and West Tank Farm Standing Order 97-01 requires that the PMST be modified to include purging of the enclosed space underneath the shielded receiver weather cover per National Fire Protection Association (NFPA) 496, Purged and Pressurized Enclosures for Electrical Equipment. The Standing Order also requires that the PMST be modified by replacing the existing electrical remote latch (RLU) unit with a mechanical remote latch unit. As the mechanical remote latch unit was exactly like the RLU installed on the Rotary Mode Core Sampler Trucks (RMCST) and the design for the RMCST went through formal design review, replacing the RLU was done utilizing informal design verification and was completed per work package ES-97-0028. As the weather cover purge was similar to the design for the RMCSTS, this design was reviewed using the independent review method with multiple independent reviewers. A function design criteria (WHC-SD-WM-FDC-048, Functional Design Criteria for Core Sampling in Flammable Gas Watch List Tanks) provided the criteria for the modifications. The review consisted of distributing the design review package to the reviewers and collecting and dispositioning the RCR comments. The review package included the ECNs for review, the Design Compliance Matrix, copies of all drawings affected, and copies of outstanding ECNs against these drawings. A final meeting was held to ensure that all reviewers were aware of the changes to ECNs from incorporation of RCR comments.

  18. Evidence of ion intercalation mediated band structure modification and opto-ionic coupling in lithium niobite

    SciTech Connect (OSTI)

    Shank, Joshua C.; Tellekamp, M. Brooks; Doolittle, W. Alan

    2015-01-21

    The theoretically suggested band structure of the novel p-type semiconductor lithium niobite (LiNbO{sub 2}), the direct coupling of photons to ion motion, and optically induced band structure modifications are investigated by temperature dependent photoluminescence. LiNbO{sub 2} has previously been used as a memristor material but is shown here to be useful as a sensor owing to the electrical, optical, and chemical ease of lithium removal and insertion. Despite the high concentration of vacancies present in lithium niobite due to the intentional removal of lithium atoms, strong photoluminescence spectra are observed even at room temperature that experimentally confirm the suggested band structure implying transitions from a flat conduction band to a degenerate valence band. Removal of small amounts of lithium significantly modifies the photoluminescence spectra including additional larger than stoichiometric-band gap features. Sufficient removal of lithium results in the elimination of the photoluminescence response supporting the predicted transition from a direct to indirect band gap semiconductor. In addition, non-thermal coupling between the incident laser and lithium ions is observed and results in modulation of the electrical impedance.

  19. Application of polymer gels for profile modification and sweep improvement of gas flooding

    SciTech Connect (OSTI)

    Raible, C.; Zhu, T.

    1992-12-01

    Early CO{sub 2} breakthrough can be a serious problem during miscible and immiscible CO{sub 2} flooding of reservoirs with heterogeneous formations. One potential method to reduce the problem of gas channeling is the use of a gel to restrict flow of fluids into the high-permeability zones. This study included evaluation of several different candidates for their potential as gelled polymer treatments for in situ profile modification. The objective of gel treatments is to restrict flow through fractures and high permeability zones without significantly damaging the adjacent oil productive zones. This involves injection of viscous polymer solution, hopefully into a high-permeability zone. In this study, layered sandpacks were used to show the effect of gelant mobility on gel penetration and placement. X-ray computerized tomography (CT) was used to visualize the flow path of the injected gelant and the location of gel placement. A conventional gel of xanthan and Cr(III) as a crosslinking agent was used for experimental model studies. The results of experimental model studies demonstrated the effects of viscous crossflow which may damage the oil productive strata. More specifically these studies of layered models showed that unless there is a very high-permeability contrast, such as a fractured zone, a considerable volume of viscous crossflow will occur with damage to oil productive strata. These results indicated the need for injection and placement of a low viscosity gelant prior to gelation.

  20. Application of polymer gels for profile modification and sweep improvement of gas flooding

    SciTech Connect (OSTI)

    Raible, C.; Zhu, T.

    1992-12-01

    Early CO[sub 2] breakthrough can be a serious problem during miscible and immiscible CO[sub 2] flooding of reservoirs with heterogeneous formations. One potential method to reduce the problem of gas channeling is the use of a gel to restrict flow of fluids into the high-permeability zones. This study included evaluation of several different candidates for their potential as gelled polymer treatments for in situ profile modification. The objective of gel treatments is to restrict flow through fractures and high permeability zones without significantly damaging the adjacent oil productive zones. This involves injection of viscous polymer solution, hopefully into a high-permeability zone. In this study, layered sandpacks were used to show the effect of gelant mobility on gel penetration and placement. X-ray computerized tomography (CT) was used to visualize the flow path of the injected gelant and the location of gel placement. A conventional gel of xanthan and Cr(III) as a crosslinking agent was used for experimental model studies. The results of experimental model studies demonstrated the effects of viscous crossflow which may damage the oil productive strata. More specifically these studies of layered models showed that unless there is a very high-permeability contrast, such as a fractured zone, a considerable volume of viscous crossflow will occur with damage to oil productive strata. These results indicated the need for injection and placement of a low viscosity gelant prior to gelation.

  1. Plasma processing of large curved surfaces for superconducting rf cavity modification

    SciTech Connect (OSTI)

    Upadhyay, J; Im, Do; Popovi??, S; Valente-Feliciano, A -M; Phillips, L; Vuskovic, L

    2014-12-01

    Plasma based surface modification of niobium is a promising alternative to wet etching of superconducting radio frequency (SRF) cavities. The development of the technology based on Cl2/Ar plasma etching has to address several crucial parameters which influence the etching rate and surface roughness, and eventually, determine cavity performance. This includes dependence of the process on the frequency of the RF generator, gas pressure, power level, the driven (inner) electrode configuration, and the chlorine concentration in the gas mixture during plasma processing. To demonstrate surface layer removal in the asymmetric non-planar geometry, we are using a simple cylindrical cavity with 8 ports symmetrically distributed over the cylinder. The ports are used for diagnosing the plasma parameters and as holders for the samples to be etched. The etching rate is highly correlated with the shape of the inner electrode, radio-frequency (RF) circuit elements, chlorine concentration in the Cl2/Ar gas mixtures, residence time of reactive species and temperature of the cavity. Using cylindrical electrodes with variable radius, large-surface ring-shaped samples and d.c. bias implementation in the external circuit we have demonstrated substantial average etching rates and outlined the possibility to optimize plasma properties with respect to maximum surface processing effect.

  2. Process chemistry monitoring at the HGP-A power plant: analytical results, process problems and modifications

    SciTech Connect (OSTI)

    Thomas, D.M.

    1982-10-01

    The HGP-A generator plant began operations on June 12, 1981 and came on-line on a continuous basis on March 1, 1982. During this period process problems were identified and, in most cases, plant modifications have eliminated the difficulties. Silica in the brine was stable at a pH 7.5, however, at a pH above 9.5 deposition of silica was triggered in a brine disposal system and required abandonment of the hydrogen sulfide abatement process originally proposed for the brine system. The steam phase sulfide abatement system for standby conditions was 90% effective, although superheat in the treatment system reduced abatement efficiency. Brine carryover through the separator was very low; however, scale deposition on the turbine blades resulted in substantial damage to the turbine. Non-condensable gases in the condenser were weakly partitioned into the liquid phase, and about 99% were carried into the off-gas treatment system which was found to be approximately 99% effective.

  3. Human Factors Engineering Analysis Tool

    Energy Science and Technology Software Center (OSTI)

    2002-03-04

    HFE-AT is a human factors engineering (HFE) software analysis tool (AT) for human-system interface design of process control systems, and is based primarily on NUREG-0700 guidance.

  4. LENS repair and modification of metal NW components:materials and applications guide.

    SciTech Connect (OSTI)

    Smugeresky, John E. (Sandia National Laboratories, Livermore, CA); Gill, David Dennis; Oberhaus, Jason (BWXT Y-12); Adams, Thad; VanCamp, Chad

    2006-11-01

    Laser Engineered Net Shaping{trademark} (LENS{reg_sign}) is a unique, layer additive, metal manufacturing technique that offers the ability to create fully dense metal features and components directly from a computer solid model. LENS offers opportunities to repair and modify components by adding features to existing geometry, refilling holes, repairing weld lips, and many other potential applications. The material deposited has good mechanical properties with strengths typically slightly higher that wrought material due to grain refinement from a quickly cooling weld pool. The result is a material with properties similar to cold worked material, but without the loss in ductility traditionally seen with such treatments. Furthermore, 304L LENS material exhibits good corrosion resistance and hydrogen compatibility. This report gives a background of the LENS process including materials analysis addressing the requirements of a number of different applications. Suggestions are given to aid both the product engineer and the process engineer in the successful utilization of LENS for their applications. The results of testing on interface strength, machinability, weldability, corrosion resistance, geometric effects, heat treatment, and repair strategy testing are all included. Finally, the qualification of the LENS process is briefly discussed to give the user confidence in selecting LENS as the process of choice for high rigor applications. The testing showed LENS components to have capability in repair/modification applications requiring complex castings (W80-3 D-Bottle bracket), thin wall parts requiring metal to be rebuilt onto the part (W87 Firing Set Housing and Y-12 Test Rings), the filling of counterbores for use in reservoir reclamation welding (SRNL hydrogen compatibility study) and the repair of surface defects on pressure vessels (SRNL gas bottle repair). The material is machinable, as testing has shown that LENS deposited material machines similar to that of

  5. Factorization, power corrections, and the pion form factor

    SciTech Connect (OSTI)

    Rothstein, Ira Z.

    2004-09-01

    This paper is an investigation of the pion form factor utilizing recently developed effective field theory techniques. The primary results reported are both the transition and electromagnetic form factors are corrected at order {lambda}/Q due to time ordered products which account for deviations of the pion from being a state composed purely of highly energetic collinear quarks in the lab frame. The usual higher twist wave function corrections contribute only at order {lambda}{sup 2}/Q{sup 2}, when the quark mass vanishes. In the case of the electromagnetic form factor the {lambda}/Q power correction is enhanced by a power of 1/{alpha}{sub s}(Q) relative to the leading order result of Brodsky and Lepage, if the scale {radical}({lambda}Q) is nonperturbative. This enhanced correction could explain the discrepancy with the data.

  6. Liquid phase methanol LaPorte process development unit: Modification, operation, and support studies

    SciTech Connect (OSTI)

    Not Available

    1991-01-02

    Liquid-entrained operations at the LaPorte Liquid Phase Methanol (LPMEOH) Process Development Unit (PDU) continued during June and July 1988 under Tasks 2.1 and 2.2 of Contract No. DE-AC22-87PC90005 for the US Department of Energy. The primary focus of this PDU operating program was to prepare for a confident move to the next scale of operation with an optimized and simplified process. Several new design options had been identified and thoroughly evaluated in a detailed process engineering study completed under the LPMEOH Part-2 contract (DE-AC22-85PC80007), which then became the basis for the current PDU modification/operating program. The focus of the Process Engineering Design was to optimize and simplifications focused on the slurry loop, which consists of the reactor, vapor/liquid separator, slurry heat exchanger, and slurry circulation pump. Two-Phase Gas Holdup tests began at LaPorte in June 1988 with nitrogen/oil and CO- rich gas/oil systems. The purpose of these tests was to study the hydrodynamics of the reactor, detect metal carbonyl catalyst poisons, and train operating personnel. Any effect of the new gas sparger and the internal heat exchanger would be revealed by comparing the hydrodynamic data with previous PDU hydrodynamic data. The Equipment Evaluation'' Run E-5 was conducted at the LaPorte LPMEOH PDU in July 1988. The objective of Run E-5 was to systematically evaluate each new piece of equipment (sparger, internal heat exchanger, V/L disengagement zone, demister, and cyclone) which had been added to the system, and attempt to run the reactor in an internal-only mode. In addition, a successful catalyst activation with a concentrated (45 wt % oxide) slurry was sought. 9 refs., 26 figs., 15 tabs.

  7. Three-Dimensional Path Planning Software-Assisted Transjugular Intrahepatic Portosystemic Shunt: A Technical Modification

    SciTech Connect (OSTI)

    Tsauo, Jiaywei Luo, Xuefeng; Ye, Linchao; Li, Xiao

    2015-06-15

    PurposeThis study was designed to report our results with a modified technique of three-dimensional (3D) path planning software assisted transjugular intrahepatic portosystemic shunt (TIPS).Methods3D path planning software was recently developed to facilitate TIPS creation by using two carbon dioxide portograms acquired at least 20° apart to generate a 3D path for overlay needle guidance. However, one shortcoming is that puncturing along the overlay would be technically impossible if the angle of the liver access set and the angle of the 3D path are not the same. To solve this problem, a prototype 3D path planning software was fitted with a utility to calculate the angle of the 3D path. Using this, we modified the angle of the liver access set accordingly during the procedure in ten patients.ResultsFailure for technical reasons occurred in three patients (unsuccessful wedged hepatic venography in two cases, software technical failure in one case). The procedure was successful in the remaining seven patients, and only one needle pass was required to obtain portal vein access in each case. The course of puncture was comparable to the 3D path in all patients. No procedure-related complication occurred following the procedures.ConclusionsAdjusting the angle of the liver access set to match the angle of the 3D path determined by the software appears to be a favorable modification to the technique of 3D path planning software assisted TIPS.

  8. Request for modification of 200 Area effluent treatment facility final delisting

    SciTech Connect (OSTI)

    BOWMAN, R.C.

    1998-11-19

    A Delisting Petition submitted to the U.S. Environmental Protection Agency in August 1993 addressed effluent to be generated at the 200 Area Effluent Treatment Facility from treating Hanford Facility waste streams. This Delisting Petition requested that 71.9 million liters per year of treated effluent, bearing the designation 'F001' through 'F005', and/or 'F039' that is derived from 'F001' through 'F005' waste, be delisted. On June 13, 1995, the U.S. Environmental Protection Agency published the final rule (Final Delisting), which formally excluded 71.9 million liters per year of 200 Area Effluent Treatment Facility effluent from ''being listed as hazardous wastes'' (60 FR 31115 now promulgated in 40 CFR 261). Given the limited scope, it is necessary to request a modification of the Final Delisting to address the management of a more diverse multi-source leachate (F039) at the 200 Area Effluent Treatment Facility. From past operations and current cleanup activities on the Hanford Facility, a considerable amount of both liquid and solid Resource Conservation and Recovery Act of 1976 regulated mixed waste has been and continues to be generated. Ultimately this waste will be treated as necessary to meet the Resource Conservation and Recovery Act Land Disposal Restrictions. The disposal of this waste will be in Resource Conservation and Recovery Act--compliant permitted lined trenches equipped with leachate collection systems. These operations will result in the generation of what is referred to as multi-source leachate. This newly generated waste will receive the listed waste designation of F039. This waste also must be managed in compliance with the provisions of the Resource Conservation and Recovery Act.

  9. Self-oscillating AB diblock copolymer developed by post modification strategy

    SciTech Connect (OSTI)

    Ueki, Takeshi E-mail: ryo@cross.t.u-tokyo.ac.jp; Onoda, Michika; Tamate, Ryota; Yoshida, Ryo E-mail: ryo@cross.t.u-tokyo.ac.jp; Shibayama, Mitsuhiro

    2015-06-15

    We prepared AB diblock copolymer composed of hydrophilic poly(ethylene oxide) segment and self-oscillating polymer segment. In the latter segment, ruthenium tris(2,2′-bipyridine) (Ru(bpy){sub 3}), a catalyst of the Belousov-Zhabotinsky reaction, is introduced into the polymer architecture based on N-isopropylacrylamide (NIPAAm). The Ru(bpy){sub 3} was introduced into the polymer segment by two methods; (i) direct random copolymerization (DP) of NIPAAm and Ru(bpy){sub 3} vinyl monomer and (ii) post modification (PM) of Ru(bpy){sub 3} with random copolymer of NIPAAm and N-3-aminopropylmethacrylamide. For both the diblock copolymers, a bistable temperature region (the temperature range; ΔT{sub m}), where the block copolymer self-assembles into micelle at reduced Ru(bpy){sub 3}{sup 2+} state whereas it breaks-up into individual polymer chain at oxidized Ru(bpy){sub 3}{sup 3+} state, monotonically extends as the composition of the Ru(bpy){sub 3} increases. The ΔT{sub m} of the block copolymer prepared by PM is larger than that by DP. The difference in ΔT{sub m} is rationalized from the statistical analysis of the arrangement of the Ru(bpy){sub 3} moiety along the self-oscillating segments. By using the PM method, the well-defined AB diblock copolymer having ΔT{sub m} (ca. 25 °C) large enough to cause stable self-oscillation can be prepared. The periodic structural transition of the diblock copolymer in a dilute solution ([Polymer] = 0.1 wt. %) is closely investigated in terms of the time-resolved dynamic light scattering technique at constant temperature in the bistable region. A macroscopic viscosity oscillation of a concentrated polymer solution (15 wt. %) coupled with the periodic microphase separation is also demonstrated.

  10. Surface modification induced phase transformation and structure variation on the rapidly solidified recast layer of titanium

    SciTech Connect (OSTI)

    Tsai, Ming-Hung; Haung, Chiung-Fang; Shyu, Shih-Shiun; Chou, Yen-Ru; Lin, Ming-Hong; Peng, Pei-Wen; and others

    2015-08-15

    In this study, neodymium-doped yttrium orthovanadate (Nd:YVO{sub 4}) as a laser source with different scanning speeds was used on biomedical Ti surface. The microstructural and biological properties of laser-modified samples were investigated by means of optical microscope, electron microscope, X-ray diffraction, surface roughness instrument, contact angle and cell cytotoxicity assay. After laser modification, the rough volcano-like recast layer with micro-/nanoporous structure and wave-like recast layer with nanoporous structure were generated on the surfaces of laser-modified samples, respectively. It was also found out that, an α → (α + rutile-TiO{sub 2}) phase transition occurred on the recast layers of laser-modified samples. The Ti surface becomes hydrophilic at a high speed laser scanning. Moreover, the cell cytotoxicity assay demonstrated that laser-modified samples did not influence the cell adhesion and proliferation behaviors of osteoblast (MG-63) cell. The laser with 50 mm/s scanning speed induced formation of rough volcano-like recast layer accompanied with micro-/nanoporous structure, which can promote cell adhesion and proliferation of MG-63 cell on Ti surface. The results indicated that the laser treatment was a potential technology to enhance the biocompatibility for titanium. - Highlights: • Laser induced the formation of recast layer with micro-/nanoporous structure on Ti. • An α → (α + rutile-TiO{sub 2}) phase transition was observed within the recast layer. • The Ti surface becomes hydrophilic at a high speed laser scanning. • Laser-modified samples exhibit good biocompatibility to osteoblast (MG-63) cell.

  11. Review results of a BWR standard plant PRA and an assessment of potential benefits from design modifications

    SciTech Connect (OSTI)

    Shiu, K.; Hanan, N.; Rubin, M.

    1985-01-01

    Brookhaven National Laboratory (BNL) has participated in the review of the GESSAR II Standard Boiling Water Reactor (BWR) Plant probabilistic risk assessment (PRA). One major objective of this review was to utilize the PRA as a tool for investigation of the relative benefits available for incorporation of various proposed modifications to the baseline design. This paper presents the findings of the BNL review and assessment of the impact upon core damage frequency from two suggested design modifications. This work was restricted to consideration of interal events only. Review results indicated that the point estimate core damage frequency of the GESSAR II plant is equal to 2.2 x 10/sup -5//reactor-year for a plant site located within the Mid-Atlantic Area Council Grid (MAAC) and 3.8 x 10/sup -5//reactor-year if the national average loss of offsite power initiator frequency is used.

  12. Atom-scale covalent electrochemical modification of single-layer graphene on SiC substrates by diaryliodonium salts

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Gearba, Raluca I.; Mueller, Kory M.; Veneman, Peter A.; Holliday, Bradley J.; Chan, Calvin K.; Stevenson, Keith J.

    2015-05-09

    Owing to its high conductivity, graphene holds promise as an electrode for energy devices such as batteries and photovoltaics. However, to this end, the work function and doping levels in graphene need to be precisely tuned. One promising route for modifying graphene’s electronic properties is via controlled covalent electrochemical grafting of molecules. We show that by employing diaryliodonium salts instead of the commonly used diazonium salts, spontaneous functionalization is avoided. This then allows for precise tuning of the grafting density. Moreover, by employing bis(4-nitrophenyl)iodonium(III) tetrafluoroborate (DNP) salt calibration curves, the surface functionalization density (coverage) of glassy carbon was controlled usingmore » cyclic voltammetry in varying salt concentrations. These electro-grafting conditions and calibration curves translated directly over to modifying single layer epitaxial graphene substrates (grown on insulating 6H-SiC (0 0 0 1)). In addition to quantifying the functionalization densities using electrochemical methods, samples with low grafting densities were characterized by low-temperature scanning tunneling microscopy (LT-STM). We show that the use of buffer-layer free graphene substrates is required for clear observation of the nitrophenyl modifications. Furthermore, atomically-resolved STM images of single site modifications were obtained, showing no preferential grafting at defect sites or SiC step edges as supposed previously in the literature. Most of the grafts exhibit threefold symmetry, but occasional extended modifications (larger than 4 nm) were observed as well.« less

  13. Atom-scale covalent electrochemical modification of single-layer graphene on SiC substrates by diaryliodonium salts

    SciTech Connect (OSTI)

    Gearba, Raluca I.; Mueller, Kory M.; Veneman, Peter A.; Holliday, Bradley J.; Chan, Calvin K.; Stevenson, Keith J.

    2015-05-09

    Owing to its high conductivity, graphene holds promise as an electrode for energy devices such as batteries and photovoltaics. However, to this end, the work function and doping levels in graphene need to be precisely tuned. One promising route for modifying graphenes electronic properties is via controlled covalent electrochemical grafting of molecules. We show that by employing diaryliodonium salts instead of the commonly used diazonium salts, spontaneous functionalization is avoided. This then allows for precise tuning of the grafting density. Moreover, by employing bis(4-nitrophenyl)iodonium(III) tetrafluoroborate (DNP) salt calibration curves, the surface functionalization density (coverage) of glassy carbon was controlled using cyclic voltammetry in varying salt concentrations. These electro-grafting conditions and calibration curves translated directly over to modifying single layer epitaxial graphene substrates (grown on insulating 6H-SiC (0 0 0 1)). In addition to quantifying the functionalization densities using electrochemical methods, samples with low grafting densities were characterized by low-temperature scanning tunneling microscopy (LT-STM). We show that the use of buffer-layer free graphene substrates is required for clear observation of the nitrophenyl modifications. Furthermore, atomically-resolved STM images of single site modifications were obtained, showing no preferential grafting at defect sites or SiC step edges as supposed previously in the literature. Most of the grafts exhibit threefold symmetry, but occasional extended modifications (larger than 4 nm) were observed as well.

  14. A BLAS-3 version of the QR factorization with column pivoting

    SciTech Connect (OSTI)

    Quintana-Orti, G.; Sun, X.; Bischof, C.H.

    1998-09-01

    The QR factorization with column pivoting (QRP), originally suggested by Golub is a popular approach to computing rank-revealing factorizations. Using Level 1 BLAS, it was implemented in LINPACK, and, using Level 2 BLAS, in LAPACK. While the Level 2 BLAS version delivers superior performance in general, it may result in worse performance for large matrix sizes due to cache effects. The authors introduce a modification of the QRP algorithm which allows the use of Level 3 BLAs kernels while maintaining the numerical behavior of the LINPACK and LAPACK implementations. Experimental comparisons of this approach with the LINPACK and LAPACK implementations on IBM RS/6000, SGI R8000, and DEC AXP platforms show considerable performance improvements.

  15. RAP Committee: Draft Advice re: Class III Modifications for LLBG, CWC-WRAP, and T-Plant Draft A, Rev 2

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    /24/2014 RAP Committee: Draft Advice re: Class III Modifications for LLBG, CWC-WRAP, and T-Plant Draft A, Rev 2 Draft Advice on the Class 3 Modifications to the Hanford Site RCRA Permit for the Low-Level Burial Grounds Trenches 31, 34 and 94, the Central Waste Complex and Waste Receiving and Processing Facility (CWC-WRAP) and the T-Plant Complex (T-Plant). Background Class III Permit Modifications: The Hanford Facility Dangerous Waste Permit for the treatment, storage, and disposal of dangerous

  16. Identification and modification of dynamical regions in proteins for alteration of enzyme catalytic effect

    DOE Patents [OSTI]

    Agarwal, Pratul K.

    2013-04-09

    A method for analysis, control, and manipulation for improvement of the chemical reaction rate of a protein-mediated reaction is provided. Enzymes, which typically comprise protein molecules, are very efficient catalysts that enhance chemical reaction rates by many orders of magnitude. Enzymes are widely used for a number of functions in chemical, biochemical, pharmaceutical, and other purposes. The method identifies key protein vibration modes that control the chemical reaction rate of the protein-mediated reaction, providing identification of the factors that enable the enzymes to achieve the high rate of reaction enhancement. By controlling these factors, the function of enzymes may be modulated, i.e., the activity can either be increased for faster enzyme reaction or it can be decreased when a slower enzyme is desired. This method provides an inexpensive and efficient solution by utilizing computer simulations, in combination with available experimental data, to build suitable models and investigate the enzyme activity.

  17. Identification and modification of dynamical regions in proteins for alteration of enzyme catalytic effect

    SciTech Connect (OSTI)

    Agarwal, Pratul K.

    2015-11-24

    A method for analysis, control, and manipulation for improvement of the chemical reaction rate of a protein-mediated reaction is provided. Enzymes, which typically comprise protein molecules, are very efficient catalysts that enhance chemical reaction rates by many orders of magnitude. Enzymes are widely used for a number of functions in chemical, biochemical, pharmaceutical, and other purposes. The method identifies key protein vibration modes that control the chemical reaction rate of the protein-mediated reaction, providing identification of the factors that enable the enzymes to achieve the high rate of reaction enhancement. By controlling these factors, the function of enzymes may be modulated, i.e., the activity can either be increased for faster enzyme reaction or it can be decreased when a slower enzyme is desired. This method provides an inexpensive and efficient solution by utilizing computer simulations, in combination with available experimental data, to build suitable models and investigate the enzyme activity.

  18. Transcription factor-based biosensor

    DOE Patents [OSTI]

    2013-10-08

    The present invention provides for a system comprising a BmoR transcription factor, a .sigma..sup.54-RNA polymerase, and a pBMO promoter operatively linked to a reporter gene, wherein the pBMO promoter is capable of expression of the reporter gene with an activated form of the BmoR and the .sigma..sup.54-RNA polymerase.

  19. Human factors in software development

    SciTech Connect (OSTI)

    Curtis, B.

    1986-01-01

    This book presents an overview of ergonomics/human factors in software development, recent research, and classic papers. Articles are drawn from the following areas of psychological research on programming: cognitive ergonomics, cognitive psychology, and psycholinguistics. Topics examined include: theoretical models of how programmers solve technical problems, the characteristics of programming languages, specification formats in behavioral research and psychological aspects of fault diagnosis.

  20. IPCC Emission Factor Database | Open Energy Information

    Open Energy Info (EERE)

    Emission Factor Database Jump to: navigation, search Tool Summary LAUNCH TOOL Name: IPCC Emission Factor Database AgencyCompany Organization: World Meteorological Organization,...

  1. Tetrahydroquinoline Derivatives as Potent and Selective Factor...

    Office of Scientific and Technical Information (OSTI)

    as Potent and Selective Factor XIa Inhibitors Citation Details In-Document Search Title: Tetrahydroquinoline Derivatives as Potent and Selective Factor XIa Inhibitors Authors: ...

  2. Structural basis for Tetrahymena telomerase processivity factor...

    Office of Scientific and Technical Information (OSTI)

    factor Teb1 binding to single-stranded telomeric-repeat DNA Citation Details In-Document Search Title: Structural basis for Tetrahymena telomerase processivity factor Teb1 ...

  3. Factors Impacting Decommissioning Costs - 13576

    SciTech Connect (OSTI)

    Kim, Karen; McGrath, Richard

    2013-07-01

    The Electric Power Research Institute (EPRI) studied United States experience with decommissioning cost estimates and the factors that impact the actual cost of decommissioning projects. This study gathered available estimated and actual decommissioning costs from eight nuclear power plants in the United States to understand the major components of decommissioning costs. Major costs categories for decommissioning a nuclear power plant are removal costs, radioactive waste costs, staffing costs, and other costs. The technical factors that impact the costs were analyzed based on the plants' decommissioning experiences. Detailed cost breakdowns by major projects and other cost categories from actual power plant decommissioning experiences will be presented. Such information will be useful in planning future decommissioning and designing new plants. (authors)

  4. Human factors in waste management

    SciTech Connect (OSTI)

    Moray, N.

    1994-10-01

    This article examines the role of human factors in radioactive waste management. Although few problems and ergonomics are special to radioactive waste management, some problems are unique especially with long term storage. The entire sociotechnical system must be looked at in order to see where improvement can take place because operator errors, as seen in Chernobyl and Bhopal, are ultimately the result of management errors.

  5. INJECTION PROFILE MODIFICATION IN A HOT, DEEP MINNELUSA WATER INJECTION PROJECT

    SciTech Connect (OSTI)

    Lyle A. Johnson Jr.

    2001-09-01

    As oil fields in the United States age, production enhancements and modifications will be needed to increase production from deeper and hotter oil reservoirs. New techniques and products must be tested in these areas before industry will adapt them as common practice. The Minnelusa fields of northeastern Wyoming are relatively small, deep, hot fields that have been developed in the past ten to twenty years. As part of the development, operators have established waterfloods early in the life of the fields to maximize cumulative oil production. However, channeling between injectors and producers does occur and can lead to excessive water production and bypassed oil left in the reservoir. The project evaluated the use of a recently developed, high-temperature polymer to modify the injection profiles in a waterflood project in a high-temperature reservoir. The field is the Hawk Point field in Campbell County, Wyoming. The field was discovered in 1986 and initially consisted of eight producing wells with an average depth of 11,500 feet and a temperature of 260 F (127 C). The polymer system was designed to plug the higher permeable channels and fractures to provide better conformance, i.e. sweep efficiency, for the waterflood. The project used a multi-well system to evaluate the treatment. Injection profile logging was used to evaluate the injection wells both before and after the polymer treatment. The treatment program was conducted in January 2000 with a treatment of the four injection wells. The treatment sizes varied between 500 bbl and 3,918 bbl at a maximum allowable pressure of 1,700 psig. Injection in three of the wells was conducted as planned. However, the injection in the fourth well was limited to 574 bbl instead of the planned 3,750 bbl because of a rapid increase in injection pressure, even at lower than planned injection rates. Following completion of polymer placement, the injection system was not started for approximately one week to permit the gel to

  6. The effect of chemistry modifications on the solidification behavior and weldability of Alloy 625

    SciTech Connect (OSTI)

    Cieslak, M.J.

    1988-01-01

    The purpose of this study was to examine the effect of chemistry variations on the solidification behavior and weldability of Alloy 625. As the effect of several tramp elements (i.e., S, P, etc.) could be predicted a priori, the experimental alloy design excluded these elements as factors. A 3-factor, 2-level, full fractorial experimental design was examined with the elements Nb(0 wt%, 3.5 wt%), C(0.005 wt.%, 0.035 wt.%), and Si(0.01 wt.%, 0.40 wt.%) being chosen to fill the design matrix. Compositions of the alloys studied are listed. These compositions were prepared using VIM/VAR techniques in the Sandia National Laboratories Melting and Solidification Facility. Conventional hot and cold working techniques were used to produce 3 mm thick sheet for Varestraint weldability testing. Differential thermal analysis (DTA) was used to establish significant solidification temperatures and reactions. Greater experimental detail has been given previously. 2 refs., 2 figs., 2 tabs.

  7. Modification of the U.S. Department of Energy`s (DOE) sytem of radiation protection requirements and guidance

    SciTech Connect (OSTI)

    O`Connell, P.V.; Rabovsky, J.L.; Zobel, S.G.

    1996-06-01

    DOE has undertaken a major modification of its system of radiation protection guidance and requirements. The objectives of this modification are to (1) eliminate unnecessary and redundant requirements, (2) clearly delineate requirements from guidance, (3) codify all radiation protection requirements, and (4) move from a compliance based approach towards a performance based approach. To achieve these objectives DOE has (1) canceled DOE Order 5480.11, {open_quotes}Radiation Protection for DOE Workers,{close_quotes} DOE Order 5480.15, {open_quotes}Department of Energy Laboratory Accreditation Program (DOELAP) for Personnel Dosimetry,{close_quotes} and DOE Notice 5400.13, {open_quotes}Sealed Radioactive Source Accountability,{close_quotes} (2) converted the DOE Radiological Control (RadCon) Manual from mandatory to non mandatory status, and (3) issued DOE Notice 441.1 to maintain those requirements (not in 10 CFR 835) considered necessary for radiation protection of workers. DOE has initiated actions to (1) amend 10 CFR 835 (the Federal rule on occupational radiation protection in the DOE complex) to incorporate the requirements, or their equivalent, in DOE Notice 441.1, (2) issue a technical standard containing guidance on DOELAP, (3) reissue the DOE RadCon Manual as a non mandatory technical standard that reflects the amendments to 10 CFR 835, and (4) revise the implementation guides on radiation protection for consistency with 10 CFR 835 and the RadCon Manual. As a result of these modifications, the system of radiation protection in the DOE will become more comparable with the system of radiation protection used by commercial industry and with the system of protection applied to other areas of worker health and safety.

  8. Occupational Health Services Part III Contract No. DE-AC06-04RL14383, Modification 152 Section J

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    III Contract No. DE-AC06-04RL14383, Modification 152 Section J Page J-13 J.6 List of Applicable Directives The Directives listed below can be obtained from the following websites: DOE Directives: http://www.directives.doe.gov/ DOE-RL CRD Supplements: http://idmsweb/idmsprod/livelink.exe?func=ll&objId=3423698&objAction=Open&viewType=1 Directive Identifier Title Date of Order or CRD CRD Supplement RRD 002 The Department of Energy Richland Operations Office (RL) Software Quality

  9. Sensitivity enhancement of carbon nanotube based ammonium ion sensors through surface modification by using oxygen plasma treatment

    SciTech Connect (OSTI)

    Yeo, Sanghak; Woong Jang, Chi; Lee, Seok; Min Jhon, Young; Choi, Changrok

    2013-02-18

    We have shown that the sensitivity of carbon nanotube (CNT) based sensors can be enhanced as high as 74 times through surface modification by using the inductively coupled plasma chemical vapor deposition method with oxygen. The plasma treatment power was maintained as low as 10 W within 20 s, and the oxygen plasma was generated far away from the sensors to minimize the plasma damage. From X-ray photoelectron spectroscopy analysis, we found that the concentration of oxygen increased with the plasma treatment time, which implies that oxygen functional groups or defect sites were generated on the CNT surface.

  10. 1. CONTRACT ID CODE PAGE OF PAGES AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT I11 5

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ap5,sval 2700042 1. CONTRACT ID CODE PAGE OF PAGES AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT I11 5 2. AMENDMENT/MOOIFICATION NO. 3. EFFECTIVE DATE 4. REQUISITION/PURCHASE REQ. NO.5 PROJECT NO. (If applicable) A077 See 16C 06-08RL-14383.O1 1 6. ISSUED BY CODE 7. ADMINISTERED BY (If other than Item 6) CODEJ US. Department of Energy Same as item 6. Richland Operations Office DOE Contracting POC: Richard Stimmrrel P. 0. Box 550, MSIN A7-80 (509) 376-2882 Richland, WA 99352 8 NAME AND

  11. Contract No. DE-AC27-01RV14136 Modification No. M023 SF-30 Continuation Page(s)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    M023 SF-30 Continuation Page(s) Page 2 of 6 Block 13C Continuation: This supplemental agreement is entered into pursuant to authority of: A. Section I, Clause I.82, FAR 52.243-2 Changes - Cost-Reimbursement (AUG 1987) - Alternate III (APR 1984) B. Mutual agreement Block 14 Continuation: A. Purpose of the Modification: 1. Under Section C, Statement of Work, Table C.5-1.1, Deliverables: Modify Contract Due Date for Items 2.5, 2.6, 2.7, 4.1, & 7.3, and modify Action Required for Items 4.1 and

  12. Modifications of Superconducting Properties of Niobium Caused by Nitrogen Doping Recipes for High Q Cavities

    SciTech Connect (OSTI)

    Vostrikov, Alexander; Checchin, Mattia; Grassellino, Anna; Kim, Young-Kee; Romanenko, Alexander

    2015-06-01

    A study is presented on the superconducting properties of niobium used for the fabrication of the SRF cavities after treating by recently discovered nitrogen doping methods. Cylindrical niobium samples have been subjected to the standard surface treatments applied to the cavities (electro-polishing, l 20°C bake) and compared with samples treated by additional nitrogen doping recipes routinely used to reach ultra-high quality factor values (>3· 1010 at 2 K, 16 MV/m). The DC magnetization curves and the complex magnetic AC susceptibility have been measured. Evidence for the lowered field of first flux penetration after nitrogen doping is found suggesting a correlation with the lowered quench fields. Superconducting critical temperatures Tc = 9.25 K are found to be in agreement with previous measurements, and no strong effect on the critical surface field (Bd) from nitrogen doping was found.

  13. Atomistic simulation of laser-pulse surface modification: Predictions of models with various length and time scales

    SciTech Connect (OSTI)

    Starikov, Sergey V. Pisarev, Vasily V.

    2015-04-07

    In this work, the femtosecond laser pulse modification of surface is studied for aluminium (Al) and gold (Au) by use of two-temperature atomistic simulation. The results are obtained for various atomistic models with different scales: from pseudo-one-dimensional to full-scale three-dimensional simulation. The surface modification after laser irradiation can be caused by ablation and melting. For low energy laser pulses, the nanoscale ripples may be induced on a surface by melting without laser ablation. In this case, nanoscale changes of the surface are due to a splash of molten metal under temperature gradient. Laser ablation occurs at a higher pulse energy when a crater is formed on the surface. There are essential differences between Al ablation and Au ablation. In the first step of shock-wave induced ablation, swelling and void formation occur for both metals. However, the simulation of ablation in gold shows an additional athermal type of ablation that is associated with electron pressure relaxation. This type of ablation takes place at the surface layer, at a depth of several nanometers, and does not induce swelling.

  14. Determining copper and lead binding in Larrea tridentata through chemical modification and X-ray absorption spectroscopy

    SciTech Connect (OSTI)

    Polette, L.; Gardea-Torresdey, J.L.; Chianelli, R.; Pickering, I.J.; George, G.N.

    1997-12-31

    Metal contamination in soils has become a widespread problem. Emerging technologies, such as phytoremediation, may offer low cost cleanup methods. The authors have identified a desert plant, Larrea tridentata (creosote bush), which naturally grows and uptakes copper and lead from a contaminated area near a smelting operation. They determined, through chemical modification of carboxyl groups with methanol, that these functional groups may be responsible for a portion of copper(II) binding. In contrast, lead binding was minimally affected by modification of carboxyl groups. X-ray absorption spectroscopy studies conducted at Stanford Synchrotron Radiation Laboratory (SSRL) further support copper binding to oxygen-coordinated ligands and also imply that the binding is not solely due to phytochelatins. The EXAFS data indicate the presence of both Cu-O and Cu-S back scatters, no short Cu-Cu interactions, but with significant Cu-Cu back scattering at 3.7 {angstrom} (unlike phytochelatins with predominantly Cu-S coordination and short Cu-Cu interactions at 2.7 {angstrom}). Cu EXAFS of roots and leaves also vary depending on the level of heavy metal contamination in the environment from which the various creosote samples were obtained. In contrast, Pb XANES data of roots and leaves of creosote collected from different contaminated sites indicate no difference in valence states or ligand coordination.

  15. Modification of modulated plasma plumes for the quasi-phase-matching of high-order harmonics in different spectral ranges

    SciTech Connect (OSTI)

    Ganeev, R. A.; Boltaev, G. S.; Sobirov, B.; Reyimbaev, S.; Sherniyozov, H.; Usmanov, T.; Suzuki, M.; Yoneya, S.; Kuroda, H.

    2015-01-15

    We demonstrate the technique allowing the fine tuning of the distance between the laser-produced plasma plumes on the surfaces of different materials, as well as the variation of the sizes of these plumes. The modification of plasma formations is based on the tilting of the multi-slit mask placed between the heating laser beam and target surface, as well as the positioning of this mask in the telescope placed on the path of heating radiation. The modulated plasma plumes with the sizes of single plume ranging between 0.1 and 1 mm were produced on the manganese and silver targets. Modification of the geometrical parameters of plasma plumes proved to be useful for the fine tuning of the quasi-phase-matched high-order harmonics generated in such structures during propagation of the ultrashort laser pulses. We show the enhancement of some groups of harmonics along the plateau range and the tuning of maximally enhanced harmonic by variable modulation of the plasma.

  16. Proposed modifications to the Lower Mokelumne River Project, California: FERC Project No. 2916-004. Final environmental impact statement

    SciTech Connect (OSTI)

    Not Available

    1993-11-01

    This final environmental impact statement (FEIS) has been prepared for the Federal Energy Regulatory Commission (Commission) to consider modifications to the existing Lower Mokelumne River Project (LMRP) (FERC Project No. 2916-004) in California. Chinook salmon and steelhead trout populations in the lower Mokelumne River have experienced recent declines and fish kills associated, in part, with discharges from Camanche Dam. The California Department of Fish and Game and the California Sportfishing Protection Alliance have asked the Commission to investigate and correct these problems. A wide range of different mitigation actions has been proposed by parties participating in the scoping of this proceeding, and staff has evaluated these proposed actions in this assessment. The staff is recommending a combination of flow and non-flow modifications to the existing license, including new minimum flow and minimum pool elevation requirements at Camanche Reservoir, ramping rates on dam releases, interim attraction and out-migrant spike flows, instream habitat improvements, and a series of studies and monitoring to determine feasible means for solving off-site fish passage problems.

  17. DRSPALL: Impact of the Modification of the Numerical Spallings Model on Waste Isolation Pilot Plant Performance Assessment.

    SciTech Connect (OSTI)

    Kicker, Dwayne Curtis; Herrick, Courtney G.; Zeitler, Todd; Malama, Bwalya; Rudeen, David Keith; Gilkey, Amy P.

    2016-01-01

    The numerical code DRSPALL (from direct release spallings) is written to calculate the volume of Waste Isolation Pilot Plant (WIPP) solid waste subject to material failure and transport to the surface as a result of a hypothetical future inadvertent drilling intrusion. An error in the implementation of the DRSPALL finite difference equations was discovered as documented in Software Problem Report (SPR) 13-001. The modifications to DRSPALL to correct the finite difference equations are detailed, and verification and validation testing has been completed for the modified DRSPALL code. The complementary cumulative distribution function (CCDF) of spallings releases obtained using the modified DRSPALL is higher compared to that found in previous WIPP performance assessment (PA) calculations. Compared to previous PAs, there was an increase in the number of vectors that result in a nonzero spallings volume, which generally translates to an increase in spallings releases. The overall mean CCDFs for total releases using the modified DRSPALL are virtually unchanged, thus the modification to DRSPALL did not impact WIPP PA calculation results.

  18. Characterization of Interlayer Cs+ in Clay Samples Using Secondary Ion Mass Spectrometry with Laser Sample Modification

    SciTech Connect (OSTI)

    G. S. Groenewold; R. Avci; C. Karahan; K. Lefebre; R. V. Fox; M. M. Cortez; A. K. Gianotto; J. Sunner; W. L. Manner

    2004-04-01

    Ultraviolet laser irradiation was used to greatly enhance the secondary ion mass spectrometry (SIMS) detection of Cs+ adsorbed to soil consisting of clay and quartz. Imaging SIMS showed that the enhancement of the Cs+ signal was spatially heterogeneous: the intensity of the Cs+ peak was increased by factors up to 100 for some particles but not at all for others. Analysis of standard clay samples exposed to Cs+ showed a variable response to laser irradiation depending on the type of clay analyzed. The Cs+ abundance was significantly enhanced when Cs+-exposed montmorillonite was irradiated and then analyzed using SIMS, which contrasted with the behavior of Cs+-exposed kaolinite, which displayed no Cs+ enhancement. Exposed illitic clays displayed modest enhancement of Cs+ upon laser irradiation, intermediate between that of kaolinite and montmorillonite. The results for Cs+ were rationalized in terms of adsorption to interlayer sites within the montmorillonite, which is an expandable phyllosilicate. In these locations, Cs+ was not initially detectable using SIMS. Upon irradiation, Cs+ was thermally redistributed, which enabled detection using SIMS. Since neither the illite nor the kaolinite is an expandable clay, adsorption to inner-layer sites does not occur, and either modest or no laser enhancement of the Cs+ signal is observed. Laser irradiation also produced unexpected enhancement of Ti+ from illite and kaolinite clays that contained small quantities of Ti, which indicates the presence of microscopic titanium oxide phases in the clay materials.

  19. DDR-type zeolite membrane synthesis, modification and gas permeation studies

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Yang, Shaowei; Cao, Zishu; Arvanitis, Antonios; Sun, Xinhui; Xu, Zhi; Dong, Junhang

    2016-01-22

    DDR-type zeolite membrane was synthesized on porous α-alumina substrate by hydrothermal treatment of a ball-milled Sigmal-1 crystal seed layer in an aluminum-free precursor solution containing 1-Adamantylamine as the structure directing agent (SDA). The as-synthesized DDR zeolite membranes were defect-free but the supported zeolite layers were susceptible to crack development during the subsequent high-temperature SDA removal process. The cracks were effectively eliminated by the liquid phase chemical deposition method using tetramethoxysilane as the precursor for silica deposits. The modified membrane was extensively studied for H2, He, O2, N2, CO2, CH4, and i-C4H10 pure gas permeation and CO2/CH4 mixture separation. At 297more » K and 2-bar feed gas pressure, the membrane achieved a CO2/CH4 separation factor of ~92 for a feed containing 90% CO2, which decreased to 62 for a feed containing 10% CO2 with the CO2 permeance virtually unchanged at ~1.8×10–7 mol/m• sup>2 s • Pa regardless of the feed composition. It also exhibited an O2/N2 permselectivity of 1.8 at 297 K. Furthermore, the gas permeation behaviors of the current aluminum-containing DDR type zeolite membrane are generally in good agreement with the findings in both experimental and theoretical studies on the pure-silica DDR membranes in recent literature.« less

  20. Cone Penetrometer N Factor Determination Testing Results

    SciTech Connect (OSTI)

    Follett, Jordan R.

    2014-03-05

    This document contains the results of testing activities to determine the empirical 'N Factor' for the cone penetrometer in kaolin clay simulant. The N Factor is used to releate resistance measurements taken with the cone penetrometer to shear strength.

  1. Fatigue life improvement factors obtained by weld reinforcement and toe grinding

    SciTech Connect (OSTI)

    Mullen, C.L.; Merwin, J.E.

    1982-01-01

    The potential of weld reinforcement and toe grinding techniques for improving the fatigue life of welded joints protected from seawater corrosion is quantified based on tests performed in air on welded plate specimens. Results are presented in terms of median fatigue life improvement factors and prediction intervals obtained by linear regression analysis. The significant improvements possible with weld reinforcement are shown to be caused partly by a slight alleviation of the stress concentration imposed by sharp angles at the weld toe. Variable improvements observed for toe ground welds are shown to be associated with the variable surface modifications which different tools impose on weld toes. Load and weld geometry are shown to be particulary important when bending stresses are applied to the weld toe, since reinforcement affects the bending moment at the toe section and toe grinding affects the conditions at the highly stressed outer fibers. 14 references.

  2. Clothes Washer Test Cloth Correction Factor Information

    Broader source: Energy.gov [DOE]

    This page contains the information used to determine the test cloth correction factors for each test cloth lot.

  3. Structural Modification of Single Wall and Multiwalled Carbon Nanotubes under Carbon, Nickel and Gold Ion Beam Irradiation

    SciTech Connect (OSTI)

    Jeet, Kiran; Jindal, V. K.; Dharamvir, Keya; Bharadwaj, L. M.

    2011-12-12

    Thin film samples of carbon nanotubes were irradiated with ion beam of carbon, nickel and gold. The irradiation results were characterized using Raman Spectroscopy. Modifications of the disorder mode (D mode) and the tangential mode (G mode) under different irradiation fluences were studied in detail. Raman results of carbon ion beam indicate the interesting phenomenon of ordering of the system under irradiation. Under the effect of nickel and gold ion irradiation, the structural evolution of CNTs occurs in three different stages. At lower fluences the process of healing occurs; at intermediate fluences damages on the surface of CNTs occurs and finally at very high fluences of the order of 1x10{sup 14} ions/cm{sup 2} the system gets amorphised.

  4. Effect of Surface Modification by Chelating Agents on Fischer- Tropsch Performance of Co/SiO{sub 2} Catalysts

    SciTech Connect (OSTI)

    Bambal, Ashish S.; Kugler, Edwin L.; Gardner, Todd H.; Dadyburjor, Dady B.

    2013-11-14

    The silica support of a Co-based catalyst for Fischer-Tropsch (FT) synthesis was modified by the chelating agents (CAs) nitrilotriacetic acid (NTA) and ethylenediaminetetraacetic acid (EDTA). After the modification, characterization of the fresh and spent catalysts show reduced crystallite sizes, a better-dispersed Co₃O₄ phase on the calcined samples, and increased metal dispersions for the reduced samples. The CA-modified catalysts display higher CO conversions, product yields, reaction rates and rate constants. The improved FT performance of CA-modified catalysts is attributed to the formation of stable complexes with Co. The superior performance of the EDTA-modified catalyst in comparison to the NTA-modified catalyst is due to the higher affinity of the former for complex formation with Co ions.

  5. Mechanism of surface modification of the Ti-6Al-4V alloy using a gas tungsten arc heat source

    SciTech Connect (OSTI)

    Labudovic, M.; Kovacevic, R.; Kmecko, I.; Khan, T.I.; Blecic, D.; Blecic, Z.

    1999-06-01

    The surface modification of a Ti-6Al-4V alloy using a gas tungsten arc, as a heat source, was studied. The experimental results show that the titanium alloy surface can be melted and nitrided using pure nitrogen or a nitrogen/argon mixture shielding atmosphere. The resolidified surfaces are 0.9 to 1.2-mm thick and contain titanium nitride dendrites, {alpha}-titanium, and {alpha}{double_prime}-titanium (martensite). The average dendrite arm spacing is influenced by the electrode speed. Small titanium nitride dendrites are homogeneously distributed in the resolidified surfaces. The microstructure and phase constitution in the resolidified surfaces were determined and analyzed, and the mechanism of the formation of titanium nitrides is discussed. The results show that the nitriding kinetics obey parabolic laws and are, therefore, controlled by nitrogen diffusion. The nitrogen-concentration depth profiles, calculated using Fick`s second law of diffusion, are compared to experimental nitrogen depth profiles, showing satisfactory agreement.

  6. High-resolution study of photoinduced modification in fused silica produced by a tightly focused femtosecond laser beam in the presence of aberrations

    SciTech Connect (OSTI)

    Hnatovsky, C.; Taylor, R.S.; Simova, E.; Bhardwaj, V.R.; Rayner, D.M.; Corkum, P.B.

    2005-07-01

    An ultrahigh-resolution (20 nm) technique of selective chemical etching and atomic force microscopy has been used to study the photoinduced modification in fused silica produced at various depths by tightly focused femtosecond laser radiation affected by spherical aberration. We demonstrate that shapes of the irradiated zones near the threshold for modification can be predicted by taking proper account of spherical aberration caused by the refractive index mismatched air-silica interface. We establish a depth dependence of the pulse energy required to initiate modification and characterize the relationship between numerical aperture of the writing lens and practically achievable writing depth. We also show that spatial characteristics of the laser-modified zones can be controlled by a specially designed focusing system which allows correction for a variable amount of spherical aberration.

  7. Human factors: a necessary tool for industry

    SciTech Connect (OSTI)

    Starcher, K.O.

    1984-03-09

    The need for human factors (ergonomics) input in the layout of a ferroelectric ceramics laboratory is presented as an example of the overall need for human factors professionals in industry. However, even in the absence of one trained in human factors, knowledge of a few principles in ergonomics will provide many possibilities for improving performance in the industrial environment.

  8. Antenna factorization in strongly ordered limits

    SciTech Connect (OSTI)

    Kosower, David A.

    2005-02-15

    When energies or angles of gluons emitted in a gauge-theory process are small and strongly ordered, the emission factorizes in a simple way to all orders in perturbation theory. I show how to unify the various strongly ordered soft, mixed soft-collinear, and collinear limits using antenna factorization amplitudes, which are generalizations of the Catani-Seymour dipole factorization function.

  9. Modifications of Carbonate Fracture Hydrodynamic Properties by CO{sub 2}-Acidified Brine Flow

    SciTech Connect (OSTI)

    Deng, Hang; Ellis, Brian R.; Peters, Catherine A.; Fitts, Jeffrey P.; Crandall, Dustin; Bromhal, Grant S.

    2013-08-01

    Acidic reactive flow in fractures is relevant in subsurface activities such as CO{sub 2} geological storage and hydraulic fracturing. Understanding reaction-induced changes in fracture hydrodynamic properties is essential for predicting subsurface flows such as leakage, injectability, and fluid production. In this study, x-ray computed tomography scans of a fractured carbonate caprock were used to create three dimensional reconstructions of the fracture before and after reaction with CO{sub 2}-acidified brine (Ellis et al., 2011, Greenhouse Gases: Sci. Technol., 1:248-260). As expected, mechanical apertures were found to increase substantially, doubling and even tripling in some places. However, the surface geometry evolved in complex ways including ‘comb-tooth’ structures created from preferential dissolution of calcite in transverse sedimentary bands, and the creation of degraded zones, i.e. porous calcite-depleted areas on reacted fracture surfaces. These geometric alterations resulted in increased fracture roughness, as measured by surface Z{sub 2} parameters and fractal dimensions D{sub f}. Computational fluid dynamics (CFD) simulations were conducted to quantify the changes in hydraulic aperture, fracture transmissivity and permeability. The results show that the effective hydraulic apertures are smaller than the mechanical apertures, and the changes in hydraulic apertures are nonlinear. Overestimation of flow rate by a factor of two or more would be introduced if fracture hydrodynamic properties were based on mechanical apertures, or if hydraulic aperture is assumed to change proportionally with mechanical aperture. The differences can be attributed, in part, to the increase in roughness after reaction, and is likely affected by contiguous transverse sedimentary features. Hydraulic apertures estimated by the 1D statistical model and 2D local cubic law (LCL) model are consistently larger than those calculated from the CFD simulations. In addition, a novel

  10. Modification of laminar flow ultrafine condensation particle counters for the enhanced detection of 1 nm condensation nuclei

    SciTech Connect (OSTI)

    Kuang, C.; Chen, M.; McMurry, P. H.; Wang, J.

    2011-10-01

    This paper describes simple modifications to thermally diffusive laminar flow ultrafine condensation particle counters (UCPCs) that allow detection of {approx}1 nm condensation nuclei with much higher efficiencies than have been previously reported. These nondestructive modifications were applied to a commercial butanol based UCPC (TSI 3025A) and to a diethylene glycol-based UCPC (UMN DEG-UCPC). Size and charge dependent detection efficiencies using the modified UCPCs (BNL 3025A and BNL DEGUCPC) were measured with high resolution mobility classified aerosols composed of NaCl, W, molecular ion standards of tetraalkyl ammonium bromide, and neutralizer-generated ions. With negatively charged NaCl aerosol, the BNL 3025A and BNL DEGUCPC achieved detection efficiencies of 37% (90x increase over TSI 3025A) at 1.68 nm mobility diameter (1.39 nm geometric diameter) and 23% (8x increase over UMN DEG-UCPC) at 1.19 nm mobility diameter (0.89 nm geometric diameter), respectively. Operating conditions for both UCPCs were identified that allowed negatively charged NaCl and W particles, but not negative ions of exactly the same mobility size, to be efficiently detected. This serendipitous material dependence, which is not fundamentally understood, suggests that vapor condensation might sometimes allow for the discrimination between air 'ions' and charged 'particles.' As a detector in a scanning mobility particle spectrometer (SMPS), a UCPC with this strong material dependence would allow for more accurate measurements of sub-2 nm aerosol size distributions due to the reduced interference from neutralizer-generated ions and atmospheric ions, and provide increased sensitivity for the determination of nucleation rates and initial particle growth rates.

  11. Applying Human Factors during the SIS Life Cycle

    SciTech Connect (OSTI)

    Avery, K.

    2010-05-05

    Safety Instrumented Systems (SIS) are widely used in U.S. Department of Energy's (DOE) nonreactor nuclear facilities for safety-critical applications. Although use of the SIS technology and computer-based digital controls, can improve performance and safety, it potentially introduces additional complexities, such as failure modes that are not readily detectable. Either automated actions or manual (operator) actions may be required to complete the safety instrumented function to place the process in a safe state or mitigate a hazard in response to an alarm or indication. DOE will issue a new standard, Application of Safety Instrumented Systems Used at DOE Nonreactor Nuclear Facilities, to provide guidance for the design, procurement, installation, testing, maintenance, operation, and quality assurance of SIS used in safety significant functions at DOE nonreactor nuclear facilities. The DOE standard focuses on utilizing the process industry consensus standard, American National Standards Institute/ International Society of Automation (ANSI/ISA) 84.00.01, Functional Safety: Safety Instrumented Systems for the Process Industry Sector, to support reliable SIS design throughout the DOE complex. SIS design must take into account human-machine interfaces and their limitations and follow good human factors engineering (HFE) practices. HFE encompasses many diverse areas (e.g., information display, user-system interaction, alarm management, operator response, control room design, and system maintainability), which affect all aspects of system development and modification. This paper presents how the HFE processes and principles apply throughout the SIS life cycle to support the design and use of SIS at DOE nonreactor nuclear facilities.

  12. Factors fragmenting the Russian Federation

    SciTech Connect (OSTI)

    Brown, E.

    1993-10-06

    This paper examines the factors that threaten the future of the Russian Federation (RF). The observations are based on a study that focused on eight republics: Mordova, Udmurtia, Tatarstan, Mari El, Bashkortostan, Kabardino-Balkaria, Buryatia, and Altay Republic. These republics were selected for their geographic and economic significance to the RF. Tatarstan, Bashkortostan, Udmurtia, and Mari El are located on important supply routes, such as the Volga River and the trans-Siberian railroad. Some of these republics are relatively wealthy, with natural resources such as oil (e.g., Tatarstan and Bashkortostan), and all eight republics play significant roles in the military-industrial complex. The importance of these republics to the RF contrasts to the relative insignificance of the independence-minded Northern Caucasus area. The author chose not to examine the Northern Caucasus region (except Kabardino-Balkaria) because these republics may have only a minor impact on the rest of the RF if they secede. Their impact would be minimized because they lie on the frontiers of the RF. Many Russians believe that {open_quotes}it might be best to let such a troublesome area secede.{close_quotes}

  13. AFS-2 FLOWSHEET MODIFICATIONS TO ADDRESS THE INGROWTH OF PU(VI) DURING METAL DISSOLUTION

    SciTech Connect (OSTI)

    Crapse, K.; Rudisill, T.; O'Rourke, P.; Kyser, E.

    2014-07-02

    to 95 °C reduced the oxidation rate of Pu(IV) to Pu(VI). For 8.1 M HNO{sub 3} simulated dissolution solutions, at near boiling conditions >35% Pu(VI) was present in 50 h while at 95 °C <10% Pu(VI) was present at 50 h. At near boiling temperatures, eliminating the presence of Cr and varying the HNO{sub 3} concentration in the range of 7–8.5 M had little effect on the rate of conversion of Pu(IV) to Pu(VI). HNO{sub 3} oxidation of Pu(IV) to Pu(VI) in a pure solution has been reported previously. Based on simulated dissolution experiments, this study concluded that dissolving Pu metal at 95°C using a 6 to 10 M HNO{sub 3} solution 0.05–0.2 M KF and 0–2 g/L B could reduce the rate of oxidation of Pu(IV) to Pu(VI) as compared to near boiling conditions. To demonstrate this flowsheet, two small-scale experiments were performed dissolving Pu metal up to 6.75 g/L. No Pu-containing residues were observed in the solutions after cooling. Using Pu metal dissolution rates measured during the experiments and a correlation developed by Holcomb, the time required to completely dissolve a batch of Pu metal in an H-Canyon dissolver using this flowsheet was estimated to require nearly 5 days (120 h). This value is reasonably consistent with an estimate based on the Batch 2 and 3 dissolution times in the 6.1D dissolver and Pu metal dissolution rates measured in this study and by Rudisill et al. Data from the present and previous studies show that the Pu metal dissolution rate decreases by a factor of approximately two when the temperature decreased from boiling (112 to 116°C) to 95°C. Therefore, the time required to dissolve a batch of Pu metal in an H-Canyon dissolver at 95°C would likely double (from 36 to 54 h) and require 72 to 108 h depending on the surface area of the Pu metal. Based on the experimental studies, a Pu metal dissolution flowsheet utilizing 6–10 M HNO{sub 3} containing 0.05–0.2 M KF (with 0–2 g/L B) at 95°C is recommended to reduce the oxidation of

  14. Factorization using the quadratic sieve algorithm

    SciTech Connect (OSTI)

    Davis, J.A.; Holdridge, D.B.

    1983-01-01

    Since the cryptosecurity of the RSA two key cryptoalgorithm is no greater than the difficulty of factoring the modulus (product of two secret primes), a code that implements the Quadratic Sieve factorization algorithm on the CRAY I computer has been developed at the Sandia National Laboratories to determine as sharply as possible the current state-of-the-art in factoring. Because all viable attacks on RSA thus far proposed are equivalent to factorization of the modulus, sharper bounds on the computational difficulty of factoring permit improved estimates for the size of RSA parameters needed for given levels of cryptosecurity. Analysis of the Quadratic Sieve indicates that it may be faster than any previously published general purpose algorithm for factoring large integers. The high speed of the CRAY I coupled with the capability of the CRAY to pipeline certain vectorized operations make this algorithm (and code) the front runner in current factoring techniques.

  15. Factorization using the quadratic sieve algorithm

    SciTech Connect (OSTI)

    Davis, J.A.; Holdridge, D.B.

    1983-12-01

    Since the cryptosecurity of the RSA two key cryptoalgorithm is no greater than the difficulty of factoring the modulus (product of two secret primes), a code that implements the Quadratic Sieve factorization algorithm on the CRAY I computer has been developed at the Sandia National Laboratories to determine as sharply as possible the current state-of-the-art in factoring. Because all viable attacks on RSA thus far proposed are equivalent to factorization of the modulus, sharper bounds on the computational difficulty of factoring permit improved estimates for the size of RSA parameters needed for given levels of cryptosecurity. Analysis of the Quadratic Sieve indicates that it may be faster than any previously published general purpose algorithm for factoring large integers. The high speed of the CRAY I coupled with the capability of the CRAY to pipeline certain vectorized operations make this algorithm (and code) the front runner in current factoring techniques.

  16. Cholix Toxin, a Novel ADP-ribosylating Factor from Vibrio cholerae

    SciTech Connect (OSTI)

    Jorgensen, Rene; Purdy, Alexandra E.; Fieldhouse, Robert J.; Kimber, Matthew S.; Bartlett, Douglas H.; Merrill, A. Rod

    2008-07-15

    The ADP-ribosyltransferases are a class of enzymes that display activity in a variety of bacterial pathogens responsible for causing diseases in plants and animals, including those affecting mankind, such as diphtheria, cholera, and whooping cough. We report the characterization of a novel toxin from Vibrio cholerae, which we call cholix toxin. The toxin is active against mammalian cells (IC50 = 4.6 {+-} 0.4 ng/ml) and crustaceans (Artemia nauplii LD50 = 10 {+-} 2 {mu}g/ml). Here we show that this toxin is the third member of the diphthamide-specific class of ADP-ribose transferases and that it possesses specific ADP-ribose transferase activity against ribosomal eukaryotic elongation factor 2. We also describe the high resolution crystal structures of the multidomain toxin and its catalytic domain at 2.1- and 1.25-{angstrom} resolution, respectively. The new structural data show that cholix toxin possesses the necessary molecular features required for infection of eukaryotes by receptor-mediated endocytosis, translocation to the host cytoplasm, and inhibition of protein synthesis by specific modification of elongation factor 2. The crystal structures also provide important insight into the structural basis for activation of toxin ADP-ribosyltransferase activity. These results indicate that cholix toxin may be an important virulence factor of Vibrio cholerae that likely plays a significant role in the survival of the organism in an aquatic environment.

  17. A Comparison of Modifications to MELCOR versions 1.8.2 and 1.8.6 for ITER Safety Analysis

    SciTech Connect (OSTI)

    B. J. Merrill; P. W. Humrickhouse

    2010-06-01

    During the Engineering Design Activity of the International Thermonuclear Experimental Reactor (ITER), the MELCOR 1.8.2 code was selected as one of several codes to be used to perform ITER safety analyses [1]. MELCOR was chosen because it has the capability of predicting coolant pressure, temperature, mass flow rate, and radionuclide and aerosol transport in nuclear facilities and reactor cooling systems. MELCOR can also predict structural temperatures (e.g. first wall, blanket, divertor, and vacuum vessel) resulting from energy produced by radioactive decay heat and/or chemical reactions (oxidation). The Idaho National Laboratory (INL) Fusion Safety Program (FSP) made fusion specific modifications to the MELCOR 1.8.2 code [2-6], including models for water freezing, air condensation, beryllium, carbon, and tungsten oxidation in steam and air environments, flow boiling in coolant loops, and radiation in enclosures, that allowed MELCOR to assess the thermal hydraulic response of ITER cooling systems and the transport of radionuclides as aerosols during accident conditions. Recently, the ITER International Organization (IO) used a “pedigreed” version of MELCOR 1.8.2 [7] to perform accident analyses for ITER’s “Rapport Préliminaire de Sûreté” (Report Preliminary on Safety - RPrS). The MELCOR thermal-hydraulics code [8] is currently under development at the Sandia National Laboratory (SNL) for the US Nuclear Regulatory Commission (NRC). MELCOR is used to model the progression of severe accidents in light water fission reactors. Because MELCOR has undergone many improvements between version 1.8.2 and 1.8.6, the INL FSP decided to introduce fusion modifications into MELCOR 1.8.6, and thereby produce a version of MELCOR 1.8.6 with similar capabilities to the pedigreed version of MELCOR 1.8.2 used for the ITER RPrS. We have applied this version of MELCOR 1.8.6 to the same set of problems used in the MELCOR 1.8.2 pedigree analysis [7]. Section 2 describes a non

  18. Impact of the In-medium Nucleon-nucleon Cross Section Modification on Early-reaction-phase Dynamics Below 100 A MeV

    SciTech Connect (OSTI)

    Basrak, Z.; Zoric, M.; Eudes, P.; Sebille, F.

    2009-08-26

    With a semi-classical transport model studied is the impact of the in-medium NN cross section modifications on the early energy transformation, dynamical emission and quasiprojectile properties of the Ar+Ni and Ni+Ni reactions at 52, 74 and 95(90) A MeV.

  19. Risk evaluation of the alternate-3A modification to the ATWS prevention/mitigation system in a BWR-4, Mark-II power plant

    SciTech Connect (OSTI)

    Papazoglou, I.A.; Karol, R.; Shiu, K.; Bari, R.A.

    1983-01-01

    Purpose of this paper is to present a risk evaluation of the ATWS Alternate 3A modification (ATWS-3A) proposed by NRC staff in NUREG-0460 to the ATWS prevention/mitigation system in a BWR nuclear power plant. The evaluation is done relative to three risk indices: the frequency of core damage, the expected early fatalities, and the expected latent fatalities.

  20. Achievement of Low Emissions by Engine Modification to Utilize Gas-to-Liquid Fuel and Advanced Emission Controls on a Class 8 Truck

    SciTech Connect (OSTI)

    Alleman, T. L.; Tennant, C. J.; Hayes, R. R.; Miyasato, M.; Oshinuga, A.; Barton, G.; Rumminger, M.; Duggal, V.; Nelson, C.; Ray, M.; Cherrillo, R. A.

    2005-11-01

    A 2002 Cummins ISM engine was modified to be optimized for operation on gas-to-liquid (GTL) fuel and advanced emission control devices. The engine modifications included increased exhaust gas recirculation (EGR), decreased compression ratio, and reshaped piston and bowl configuration.

  1. Class 1 Permit Modification Notification Addition of Structures within Technical Area 54, Area G, Pad 11, Dome 375 Los Alamos National Laboratory Hazardous Waste Facility Permit, July 2012

    SciTech Connect (OSTI)

    Vigil-Holterman, Luciana R.; Lechel, Robert A.

    2012-08-31

    The purpose of this letter is to notify the New Mexico Environment Department-Hazardous Waste Bureau (NMED-HWB) of a Class 1 Permit Modification to the Los Alamos National Laboratory (LANL) Hazardous Waste Facility Permit issued to the Department of Energy (DOE) and Los Alamos National Security, LLC (LANS) in November 2010. The modification adds structures to the container storage unit at Technical Area (TA) 54 Area G, Pad 11. Permit Section 3.1(3) requires that changes to the location of a structure that does not manage hazardous waste shall be changed within the Permit as a Class 1 modification without prior approval in accordance with Code of Federal Regulations, Title 40 (40 CFR), {section}270.42(a)(1). Structures have been added within Dome 375 located at TA-54, Area G, Pad 11 that will be used in support of waste management operations within Dome 375 and the modular panel containment structure located within Dome 375, but will not be used as waste management structures. The Class 1 Permit Modification revises Figure 36 in Attachment N, Figures; and Figure G.12-1 in Attachment G.12, Technical Area 54, Area G, Pad 11 Outdoor Container Storage Unit Closure Plan. Descriptions of the structures have also been added to Section A.4.2.9 in Attachment A, TA - Unit Descriptions; and Section 2.0 in Attachment G.12, Technical Area 54, Area G, Pad 11 Outdoor Container Storage Unit Closure Plan. Full description of the permit modification and the necessary changes are included in Enclosure 1. The modification has been prepared in accordance with 40 CFR {section}270.42(a)(l). This package includes this letter and an enclosure containing a description of the permit modification, text edits of the Permit sections, and the revised figures (collectively LA-UR-12-22808). Accordingly, a signed certification page is also enclosed. Three hard copies and one electronic copy of this submittal will be delivered to the NMED-HWB.

  2. Modification of vortex dynamics and transport properties of transitional axisymmetric jets using zero-net-mass-flux actuation

    SciTech Connect (OSTI)

    nder, Asim; Meyers, Johan

    2014-07-15

    We study the near field of a zero-net-mass-flux (ZNMF) actuated round jet using direct numerical simulations. The Reynolds number of the jet Re{sub D} = 2000 and three ZNMF actuators are used, evenly distributed over a circle, and directed towards the main jet. The actuators are triggered in phase, and have a relatively low momentum coefficient of C{sub ?} = 0.0049 each. We study four different control frequencies with Strouhal numbers ranging from St{sub D} = 0.165 to St{sub D} = 1.32; next to that, also two uncontrolled baseline cases are included in the study. We find that this type of ZNMF actuation leads to strong deformations of the near-field jet region that are very similar to those observed for non-circular jets. At the end of the jet's potential core (x/D = 5), the jet-column cross section is deformed into a hexagram-like geometry that results from strong modifications of the vortex structures. Two mechanisms lead to these modifications, i.e., (i) self-deformation of the jet's primary vortex rings started by distortions in their azimuthal curvature by the actuation, and (ii) production of side jets by the development and subsequent detachment of secondary streamwise vortex pairs. Further downstream (x/D = 10), the jet transforms into a triangular pattern, as the sharp corner regions of the hexagram entrain fluid and spread. We further investigate the global characteristics of the actuated jets. In particular when using the jet preferred frequency, i.e., St{sub D} = 0.33, parameters such as entrainment, centerline decay rate, and mean turbulent kinetic energy are significantly increased. Furthermore, high frequency actuation, i.e., St{sub D} = 1.32, is found to suppress the mechanisms leading to large scale structure growth and turbulent kinetic energy production. The simulations further include a passive scalar equation, and passive scalar mixing is also quantified and visualized.

  3. Synthetic heparin-binding growth factor analogs

    DOE Patents [OSTI]

    Pena, Louis A.; Zamora, Paul; Lin, Xinhua; Glass, John D.

    2007-01-23

    The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain that binds a heparin-binding growth factor receptor, covalently bound to a hydrophobic linker, which is in turn covalently bound to a non-signaling peptide that includes a heparin-binding domain. The synthetic heparin-binding growth factor analogs are useful as soluble biologics or as surface coatings for medical devices.

  4. Summary - Major Risk Factors Integrated Facility Disposition...

    Office of Environmental Management (EM)

    Office of Environmental Management (DOE-EM) External Technical Review of the Major Risk Factors Integrated Facility Disposition Project (IFDP) Oak Ridge, TN Why DOE-EM Did...

  5. CONTROL OF MECHANICALLY ACTIVATED POLYMERSOME FUSION: FACTORS...

    Office of Scientific and Technical Information (OSTI)

    MECHANICALLY ACTIVATED POLYMERSOME FUSION: FACTORS AFFECTING FUSION. Henderson, Ian M.; Paxton, Walter F Abstract not provided. Sandia National Laboratories (SNL-NM), Albuquerque,...

  6. EcoFactor Inc | Open Energy Information

    Open Energy Info (EERE)

    Name: EcoFactor Inc Place: Millbrae, California Zip: 94030 Product: California-based home energy management service provider. Coordinates: 37.60276, -122.395444 Show Map...

  7. CONTROL OF MECHANICALLY ACTIVATED POLYMERSOME FUSION: FACTORS...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Journal Article: CONTROL OF MECHANICALLY ACTIVATED POLYMERSOME FUSION: FACTORS AFFECTING FUSION. Citation Details In-Document Search Title: CONTROL OF MECHANICALLY ACTIVATED...

  8. Soliton form factors from lattice simulations

    SciTech Connect (OSTI)

    Rajantie, Arttu; Weir, David J.

    2010-12-01

    The form factor provides a convenient way to describe properties of topological solitons in the full quantum theory, when semiclassical concepts are not applicable. It is demonstrated that the form factor can be calculated numerically using lattice Monte Carlo simulations. The approach is very general and can be applied to essentially any type of soliton. The technique is illustrated by calculating the kink form factor near the critical point in 1+1-dimensional scalar field theory. As expected from universality arguments, the result agrees with the exactly calculable scaling form factor of the two-dimensional Ising model.

  9. Emission Factors (EMFAC) | Open Energy Information

    Open Energy Info (EERE)

    The EMission FACtors (EMFAC) model is used to calculate emission rates from all motor vehicles, such as passenger cars to heavy-duty trucks, operating on highways, freeways...

  10. Nonrelativistic QCD factorization and the velocity dependence...

    Office of Scientific and Technical Information (OSTI)

    CONFIGURATION; FACTORIZATION; MATRIX ELEMENTS; QUANTUM CHROMODYNAMICS; QUARKONIUM; SINGULARITY; T QUARKS; VELOCITY Word Cloud More Like This Full Text Journal Articles DOI: ...

  11. Industrial Power Factor Analysis Guidebook. Electrotek Concepts...

    Office of Scientific and Technical Information (OSTI)

    low power factors, increased conductor and transformer losses, and lower voltages. Utilities must supply both active and reactive power and compensate for these losses. Power...

  12. Major Risk Factors Integrated Facility Disposition Project -...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Integrated Facility Disposition Project - Oak Ridge Major Risk Factors Integrated Facility Disposition Project - Oak Ridge Full Document and Summary Versions are available for ...

  13. Highly Effective Pt-Based Water-Gas Shift Catalysts by Surface Modification with Alkali Hydroxide Salts

    SciTech Connect (OSTI)

    Kusche, Matthias; Bustillo, Karen; Agel, Friederike; Wasserscheid, Peter

    2015-01-29

    Here, we describe an economical and convenient method to improve the performance of Pt/alumina catalysts for the water–gas shift reaction through surface modification of the catalysts with alkali hydroxides according to the solid catalyst with ionic liquid layer approach. The results are in agreement with our findings reported earlier for methanol steam reforming. This report indicates that alkali doping of the catalyst plays an important role in the observed catalyst activation. In addition, the basic and hygroscopic nature of the salt coating contributes to a significant improvement in the performance of the catalyst. During the reaction, a partly liquid film of alkali hydroxide forms on the alumina surface, which increases the availability of H2O at the catalytically active sites. Kinetic studies reveal a negligible effect of the KOH coating on the rate dependence of CO and H2O partial pressures. In conclusion, TEM studies indicate an agglomeration of the active Pt clusters during catalyst preparation; restructuring of Pt nanoparticles occurs under reaction conditions, which leads to a highly active and stable system over 240h time on stream. Excessive pore fillings with KOH introduce a mass transfer barrier as indicated in a volcano-shaped curve of activity versus salt loading. The optimum KOH loading was found to be 7.5wt%.

  14. Effect of surface modification by chelating agents on Fischer-Tropsch performance of Co/SiO2 catalysts

    SciTech Connect (OSTI)

    Bambal, Ashish S.; Kyugler, Edwin L.; Gardner, Todd H.; Dadyburjor, Dady B.

    2013-01-01

    The silica support of a Co-based catalyst for Fischer−Tropsch (FT) synthesis was modified by the chelating agents (CAs) nitrilotriacetic acid (NTA) and ethylenediaminetetraacetic acid (EDTA). After the modification, characterization of the fresh and spent catalysts shows reduced crystallite sizes, a better-dispersed Co3O4 phase on the calcined samples, and increased metal dispersions for the reduced samples. The CA-modified catalysts display higher CO conversions, product yields, reaction rates, and rate constants. The improved FT performance of CA-modified catalysts is attributed to the formation of stable complexes with Co. The superior performance of the EDTA-modified catalyst in comparison to the NTA-modified catalyst is due to the higher affinity of the former for complex formation with Co ions. 1. INTRODUCTION Fischer−Tropsch (FT) synthesis has been recognized as one of the most promising technologies for the conversion of coal, natural gas, and biomass-derived syngas into liquid fuels and chemicals.1 Limited oil reserves, energy supply security concerns, carbon credits,1 pollution abatement laws, and, most notably, uncertainty about fuel prices have increased the prospect of commercializing the FT process. Catalysts that are typically used for FT synthesis include supported Co or Fe. Cobased catalysts have the advantage of higher syngas conversion, more high-

  15. The use Na, Li, K cations for modification of ZSM-5 zewolite to control hydrocarbon cold-start emission

    SciTech Connect (OSTI)

    Golubeva V.; Rohatgi U.; Korableva, A.; Anischenko, O.; Kustov, L.; Nissenbaum, V; Viola, M.B.

    2012-08-29

    This paper addresses the problem of controlling hydrocarbon emissions from cold-start of engines by investigating the adsorbents which could adsorb the hydrocarbons at cold temperatures and hold them to 250-300 ?. The materials, that has been studied, are based on the modification of ZSM-5 (SiO{sub 2}/Al{sub 2}O{sub 3} = 35) zeolite with Li, K, Na cations. It has been shown that the introduction of Li, Na and K in an amount that is equivalent to the content of Al in zeolite results in occurrence of toluene temperature desorption peaks at high-temperatures. The toluene temperature desorption curves for 5%Li-ZSM-5 and 2.3%Na-ZSM-5 zeolites are identical and have peak toluene desorption rate between 200 to 400 ?. Upon analysis of toluene adsorption isotherms for 2.3%Na-ZSM-5 and 5%Li-ZSM-5, it was concluded that the toluene diffusion inside of the modified zeolites channels is extremely slow and the sorption capacity of 2.3%Na-ZSM-5 is higher than with 5%Li-ZSM-5. The 2.3%Na-ZSM-5 didn't change toluene temperature programmed desorption (TPD) rate of curve after the treatment in environment with 10% ?{sub 2}? at 750-800 ? for about 28 h. The 2.3%Na-ZSM-5 zeolite is very promising as adsorbent to control the cold-start hydrocarbon emissions.

  16. Development of modifications to the material point method for the simulation of thin membranes, compressible fluids, and their interactions

    SciTech Connect (OSTI)

    York, A.R. II [Sandia National Labs., Albuquerque, NM (United States). Engineering and Process Dept.] [Sandia National Labs., Albuquerque, NM (United States). Engineering and Process Dept.

    1997-07-01

    The material point method (MPM) is an evolution of the particle in cell method where Lagrangian particles or material points are used to discretize the volume of a material. The particles carry properties such as mass, velocity, stress, and strain and move through a Eulerian or spatial mesh. The momentum equation is solved on the Eulerian mesh. Modifications to the material point method are developed that allow the simulation of thin membranes, compressible fluids, and their dynamic interactions. A single layer of material points through the thickness is used to represent a membrane. The constitutive equation for the membrane is applied in the local coordinate system of each material point. Validation problems are presented and numerical convergence is demonstrated. Fluid simulation is achieved by implementing a constitutive equation for a compressible, viscous, Newtonian fluid and by solution of the energy equation. The fluid formulation is validated by simulating a traveling shock wave in a compressible fluid. Interactions of the fluid and membrane are handled naturally with the method. The fluid and membrane communicate through the Eulerian grid on which forces are calculated due to the fluid and membrane stress states. Validation problems include simulating a projectile impacting an inflated airbag. In some impact simulations with the MPM, bodies may tend to stick together when separating. Several algorithms are proposed and tested that allow bodies to separate from each other after impact. In addition, several methods are investigated to determine the local coordinate system of a membrane material point without relying upon connectivity data.

  17. Highly Effective Pt-Based Water-Gas Shift Catalysts by Surface Modification with Alkali Hydroxide Salts

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Kusche, Matthias; Bustillo, Karen; Agel, Friederike; Wasserscheid, Peter

    2015-01-29

    Here, we describe an economical and convenient method to improve the performance of Pt/alumina catalysts for the water–gas shift reaction through surface modification of the catalysts with alkali hydroxides according to the solid catalyst with ionic liquid layer approach. The results are in agreement with our findings reported earlier for methanol steam reforming. This report indicates that alkali doping of the catalyst plays an important role in the observed catalyst activation. In addition, the basic and hygroscopic nature of the salt coating contributes to a significant improvement in the performance of the catalyst. During the reaction, a partly liquid filmmore » of alkali hydroxide forms on the alumina surface, which increases the availability of H2O at the catalytically active sites. Kinetic studies reveal a negligible effect of the KOH coating on the rate dependence of CO and H2O partial pressures. In conclusion, TEM studies indicate an agglomeration of the active Pt clusters during catalyst preparation; restructuring of Pt nanoparticles occurs under reaction conditions, which leads to a highly active and stable system over 240h time on stream. Excessive pore fillings with KOH introduce a mass transfer barrier as indicated in a volcano-shaped curve of activity versus salt loading. The optimum KOH loading was found to be 7.5wt%.« less

  18. Modifications for use of methanol or methanol-gasoline blends in automotive vehicles, September 1976-January 1980

    SciTech Connect (OSTI)

    Patterson, D.J.; Bolt, J.A.; Cole, D.E.

    1980-01-01

    Methanol or blends of methanol and gasoline as automotive fuels may be attractive means for extending the nation's petroleum reserves. The present study was aimed at identifying potential problems and solutions for this use of methanol. Retrofitting of existing vehicles as well as future vehicle design have been considered. The use of ethanol or higher alcohols was not addressed in this study but will be included at a later date. Several potentially serious problems have been identified with methanol use. The most attractive solutions depend upon an integrated combination of vehicle modifications and fuel design. No vehicle problems were found which could not be solved with relatively minor developments of existing technology providing the methanol or blend fuel was itself engineered to ameliorate the solution. Research needs have been identified in the areas of lubrication and materials. These, while apparently solvable, must precede use of methanol or methanol-gasoline blends as motor fuels. Because of the substantial costs and complexities of a retrofitting program, use of methanol must be evaluated in relation to other petroleum-saving alternatives. Future vehicles can be designed initially to operate satisfactorily on these alternate fuels. However a specific fuel composition must be specified around which the future engines and vehicles can be designed.

  19. Factors controlling reservoir quality in tertiary sandstones and their significance to geopressured geothermal production. Annual report, May 1, 1979-May 31, 1980

    SciTech Connect (OSTI)

    Loucks, R.G.; Richmann, D.L.; Milliken, K.L.

    1980-07-01

    Differing extents of diagenetic modification is the factor primarily responsible for contrasting regional reservoir quality of Tertiary sandstones from the Upper and Lower Texas Gulf Coast. Detailed comparison of Frio sandstones from the Chocolate Bayou/Danbury Dome area, Brazoria County, and Vicksburg sandstones from the McAllen Ranch Field area, Hidalgo County, reveals that extent of diagenetic modification is most strongly influenced by (1) detrital mineralogy and (2) regional geothermal gradients. Vicksburg sandstones from the McAllen Ranch Field area are less stable, chemically and mechanically, than Frio sandstones from the Chocolate Bayou/Danbury dome area. Vicksburg sandstones are mineralogically immature and contain greater proportions of feldspars and rock fragments than do Frio sandstones. Thr reactive detrital assemblage of Vicksubrg sandstones is highly susceptible to diagenetic modification. Susceptibility is enhanced by higher than normal geothermal gradients in the McAllen Ranch Field area. Thus, consolidation of Vicksburg sandstones began at shallower depth of burial and precipitation of authigenic phases (especially calcite) was more pervasive than in Frio sandstones. Moreover, the late-stage episode of ferroan calcite precipitation that occluded most secondary porosity in Vicksburg sandstones did not occur significantly in Frio sandstones. Therefore, regional reservoir quality of Frio sandstones from Brazoria County is far better than that characterizing Vicksburg sandstones from Hidalgo County, especially at depths suitable for geopressured geothermal energy production.

  20. Gauss Sum Factorization with Cold Atoms

    SciTech Connect (OSTI)

    Gilowski, M.; Wendrich, T.; Mueller, T.; Ertmer, W.; Rasel, E. M. [Institut fuer Quantenoptik, Leibniz Universitaet Hannover, Welfengarten 1, D-30167 Hannover (Germany); Jentsch, Ch. [Astrium GmbH-Satellites, 88039 Friedrichshafen (Germany); Schleich, W. P. [Institut fuer Quantenphysik, Universitaet Ulm, Albert-Einstein-Allee 11, D-89081 Ulm (Germany)

    2008-01-25

    We report the first implementation of a Gauss sum factorization algorithm by an internal state Ramsey interferometer using cold atoms. A sequence of appropriately designed light pulses interacts with an ensemble of cold rubidium atoms. The final population in the involved atomic levels determines a Gauss sum. With this technique we factor the number N=263193.

  1. Proposed modifications to the RCRA post-closure permit for the Upper East Fork Poplar Creek Hydrogeologic Regime at the U.S. Department of Energy Y-12 Plant, Oak Ridge, Tennessee

    SciTech Connect (OSTI)

    1997-05-01

    This report presents proposed modifications to the Resource Conservation and Recovery Act (RCRA) Post-Closure Permit (PCP) for the Upper East Fork Poplar Creek Hydrogeologic Regime (permit number TNHW-088, EPA ID No. TN3 89 009 0001). The modifications are proposed to: (1) revise the current text for two of the Permit Conditions included in Permit Section II - General Facility Conditions, and (2) update the PCP with revised versions of the Y-12 Plant Groundwater Protection Program (GWPP) technical field procedures included in several of the Permit Attachments. The updated field procedures and editorial revisions are Class 1 permit modifications, as specified in Title 40, Code of Federal Regulations (CFR) {section}270.42; Appendix I - Classification of Permit Modifications. These modifications are summarized below.

  2. Surface modification to waveguides

    DOE Patents [OSTI]

    Timberlake, John R.; Ruzic, David N.; Moore, Richard L.; Cohen, Samuel A.; Manos, Dennis M.

    1983-01-01

    A method of treating the interior surfaces of a waveguide to improve power transmission comprising the steps of mechanically polishing to remove surface protrusions; electropolishing to remove embedded particles; ultrasonically cleaning to remove any residue; coating the interior waveguide surfaces with an alkyd resin solution or electrophoretically depositing carbon lamp black suspended in an alkyd resin solution to form a 1.mu. to 5.mu. thick film; vacuum pyrolyzing the film to form a uniform adherent carbon coating.

  3. Surface modification to waveguides

    DOE Patents [OSTI]

    Timberlake, J.R.; Ruzic, D.N.; Moore, R.L.; Cohen, S.A.; Manos, D.M.

    1982-06-16

    A method is described for treating the interior surfaces of a waveguide to improve power transmission comprising the steps of mechanically polishing to remove surface protrusions; electropolishing to remove embedded particles; ultrasonically cleaning to remove any residue; coating the interior waveguide surfaces with an alkyd resin solution or electrophoretically depositing carbon lamp black suspended in an alkyd resin solution to form a 1..mu.. to 5..mu.. thick film; vacuum pyrolyzing the film to form a uniform adherent carbon coating.

  4. TIGER Arc Modification Application

    Energy Science and Technology Software Center (OSTI)

    1995-03-06

    The application enables the geometric correction of TIGER arcs to a more accurate spatial data set. This is done in a structured automated environment according to Census Bureau guidelines and New Mexico state GIS standards. Arcs may be deleted, added, combined, split, and moved relative to a coverage or image displayed in the background.

  5. Modification PNM Guide

    Office of Environmental Management (EM)

    Models & Tools for Evaluation of Project Options Tribal Energy Program Review 2015 Lars Lisell 5/7/2015 2 Energy Audits/Energy Evaluation * Envelope/Weatherization * Lighting * HVAC * Plug loads 3 * http://www.nrel.gov/gis/ RE Resource Maps 4 * Biopower Atlas * https://mapsbeta.nrel.gov/biopower-atlas/ RE Resource Maps 5 PV Watts http://pvwatts.nrel.gov/ 6 PV Watts http://pvwatts.nrel.gov/ 7 PV Watts http://pvwatts.nrel.gov/ 8 PV Watts http://pvwatts.nrel.gov/ 9 PV Watts

  6. Modification_008.pdf

    Office of Environmental Management (EM)

  7. AMWTP Contract Modifications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    057 September 30, 2015 Funding 110 056 September 29, 2015 Change -Section B -Section C -Section F -Section J-D 154 71 113 22 54 055 August 27, 2015 Change -Section B 454 123 054...

  8. Signed Modification 176.pdf

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

  9. Synthetic heparin-binding factor analogs

    DOE Patents [OSTI]

    Pena, Louis A.; Zamora, Paul O.; Lin, Xinhua; Glass, John D.

    2010-04-20

    The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain, and preferably two peptide chains branched from a dipeptide branch moiety composed of two trifunctional amino acid residues, which peptide chain or chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a linker, which may be a hydrophobic linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.

  10. Elimination of hydrogenase post-translational modification blocks H2 production and increases ethanol yield in Clostridium thermocellum

    SciTech Connect (OSTI)

    Biswas, Ranjita; Zheng, Tianyong; Olson, Daniel G.; Lynd, Lee R; Guss, Adam M

    2015-01-01

    The native ability of Clostridium thermocellum to rapidly consume cellulose and produce ethanol makes it a leading candidate for a consolidated bioprocessing (CBP) biofuel production strategy. C. thermocellum also synthesizes lactate, formate, acetate, H2, and amino acids that compete with ethanol production for carbon and electrons. Elimination of H2 production could redirect carbon flux towards ethanol production by making more electrons available for acetyl-CoA reduction to ethanol. C. thermocellum encodes four hydrogenases and rather than delete each individually, we targeted a hydrogenase maturase gene (hydG), involved in converting the three [FeFe] hydrogenase apoenzymes into holoenzymes. Further deletion of the [NiFe] hydrogenase (ech) resulted in a mutant that functionally lacks all four hydrogenases. H2 production in hydG ech was undetectable and ethanol yield increased nearly 2-fold compared to wild type. Interestingly, mutant growth improved upon the addition of acetate, which led to increased expression of genes related to sulfate metabolism, suggesting these mutants may use sulfate as a terminal electron acceptor to balance redox reactions. Genomic analysis of hydG revealed a mutation in adhE, resulting in a strain with both NADH- and NADPH-dependent alcohol dehydrogenase activities. While this same adhE mutation is found in ethanol tolerant C. thermocellum strain E50C, hydG and hydG ech are not more ethanol tolerant than wild type, illustrating the complicated interactions between redox balancing and ethanol tolerance in C. thermocellum. The dramatic increase in ethanol production here suggests that targeting protein post-translational modification is a promising new approach for inactivation of multiple enzymes simultaneously for metabolic engineering.

  11. Proposed amendment to presidential permit PP-63 and associated modifications to 500 kV international transmission line, Forbes, Minnesota to Manitoba, Canada. [Forbes Substation

    SciTech Connect (OSTI)

    Not Available

    1992-10-01

    This Addendum to the Final Environmental Assessment for the Proposed Amendment to Presidential Permit PP-63 and Associated Modifications to 500 kV International Transmission Line: Forbes, Minnesota to Manitoba, Canada (DOE/EA-587) addresses Northern States Power Company's (NSP) proposed expansion of the Forbes Substation. The applicant has requested that the expansion take place on the west side of the substation, within the existing property line, instead of on the north side as originally proposed. All of the proposed construction would take place on property already owned by NSP. DOE has reviewed the environmental impacts associated with this minor modification and has determined that the conclusions reached in the environmental assessment and Finding of No Significant Impact prepared in connection with NSP's original amendment request remain valid.

  12. Relativistic Thomson Scatter from Factor Calculation

    Energy Science and Technology Software Center (OSTI)

    2009-11-01

    The purpose of this program is calculate the fully relativistic Thomson scatter from factor in unmagnetized plasmas. Such calculations are compared to experimental diagnoses of plasmas at such facilities as the Jupiter laser facility here a LLNL.

  13. Carbon Dioxide Emission Factors for Coal

    Reports and Publications (EIA)

    1994-01-01

    The Energy Information Administration (EIA) has developed factors for estimating the amount of carbon dioxide emitted, accounting for differences among coals, to reflect the changing "mix" of coal in U.S. coal consumption.

  14. Industrial Power Factor Analysis Guidebook. (Technical Report...

    Office of Scientific and Technical Information (OSTI)

    Power factor is a way of measuring the percentage of reactive power in an electrical system. Reactive power represents wasted energy--electricity that does no useful work because ...

  15. Excitation of guided ELF-VLF waves through modification of the F{sub 2} ionospheric layer by high-power radio waves

    SciTech Connect (OSTI)

    Markov, G. A.; Belov, A. S.; Komrakov, G. P.; Parrot, M.

    2012-03-15

    The possibility of controlled excitation of ELF-VLF electromagnetic waves through modification of the F{sub 2} ionospheric layer by high-power high-frequency emission is demonstrated in a natural experiment by using the Sura midlatitude heating facility. The excited low-frequency waves can be used to explore the near-Earth space and stimulate the excitation of a magnetospheric maser.

  16. Molten-Caustic-Leaching (Gravimelt) System Integration Project, Phase 2. Topical report for test circuit maintenance, refurbishment, modification, and off-line operation

    SciTech Connect (OSTI)

    Not Available

    1993-03-01

    This is a report of the maintenance, refurbishment, modifications, and off-line circuit component testing of the integrated test circuit of the Molten-Caustic-Leaching (MCL or Gravimelt) process for the desulfurization and demineralization of coal. The project is sponsored by the Pittsburgh Energy Technology Center of the US Department of Energy under Contract No. DE-AC22-86-PC91257.

  17. Proton form factor effects in hydrogenic atoms

    SciTech Connect (OSTI)

    Daza, F. Garcia; Kelkar, N. G.; Nowakowski, M.

    2011-10-21

    The proton structure corrections to the hyperfine splittings in electronic and muonic hydrogen are evaluated using the Breit potential with electromagnetic form factors. In contrast to other methods, the Breit equation with q{sup 2} dependent form factors is just an extension of the standard Breit equation which gives the hyperfine splitting Hamiltonian. Precise QED corrections are comparable to the structure corrections which therefore need to be evaluated ab initio.

  18. Factors affecting robust retail energy markets

    SciTech Connect (OSTI)

    Michelman, T.S.

    1999-04-01

    This paper briefly defines an active retail market, details the factors that influence market activity and their relative importance, compares activity in various retail energy markets to date, and predicts future retail energy market activity. Three primary factors translate into high market activity: supplier margins, translated into potential savings for actively shopping customers; market size; and market barriers. The author surveys activity nationwide and predicts hot spots for the coming year.

  19. Design Modifications for Increasing the BOM and EOM Power Output and Reducing the Size and Mass of RTG for the Pluto Mission

    SciTech Connect (OSTI)

    Schock, Alfred; Or, Chuen T; Kumar, Vasanth

    1994-06-01

    A companion paper analyzed the effect on source modules for three specific fuel options, and compared the predicted power output with JPL's latest goals for the Pluto Fast Flyby (PFF) mission. The results showed that a 5-module RTG cannot fully meet JPL's goals with any of the available fuels; and that a 6-module RTG more than meets those goals with Russian fuel, almost meets them with U.S. (Cassini-type) fuel, but still falls far short of meeting them with the depleted fuel from the aged (1982) Galileo spare RTG. The inadequacy of the aged fuel was disappointing,because heat source modules made from it already exist, and their use in PFF could result in substantial cost savings. The present paper describes additional analyses which showed that a six-module RTG with the aged fuel can meet JPL's stipulated power margin with a relatively simple design modification, that a second design modification makes it possible to recover all of the mass and size penalty for going from five to six heat source modules, and that a third modification could raise the EOM power margin to 16%. There are four copies in the file. Cross Reference ESD Files FSC-ESD-217-94-531 (CID #8572)

  20. Design Modifications for Increasing the BOm and EOM Power Output and Reducing the Size and Mass of RTG for the Pluto Mission

    SciTech Connect (OSTI)

    Schock, Alfred; Or, Chuen T; Kumar, Vasanth

    1994-08-01

    Paper presented at the 29th IECEC in Monterey, CA in August 1994. A companion paper analyzed the effect on source modules for three specific fuel options, and compared the predicted power output with JPL's latest goals for the Pluto Fast Flyby (PFF) mission. The results showed that a 5-module RTG cannot fully meet JPL's goals with any of the available fuels; and that a 6-module RTG more than meets those goals with Russian fuel, almost meets them with U.S. (Cassini-type) fuel, but still falls far short of meeting them with the depleted fuel from the aged (1982) Galileo spare RTG. The inadequacy of the aged fuel was disappointing,because heat source modules made from it already exist, and their use in PFF could result in substantial cost savings. The present paper describes additional analyses which showed that a six-module RTG with the aged fuel can meet JPL's stipulated power margin with a relatively simple design modification, that a second design modification makes it possible to recover all of the mass and size penalty for going from five to six heat source modules, and that a third modification could raise the EOM power margin to 16%.

  1. Microfluidic molecular assay platform for the detection of miRNAs, mRNAs, proteins, and post-translational modifications at single-cell resolution

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wu, Meiye; Singh, Anup K.

    2014-07-15

    In this study, cell signaling is a dynamic and complex process. A typical signaling pathway may begin with activation of cell surface receptors, leading to activation kinase cascade that culminates in induction of mRNA and non-coding miRNA production in the nucleus, followed by modulation of mRNA expression by miRNAs in the cytosol, and end with production of proteins in response to the signaling pathway. Signaling pathways involve proteins, miRNA, and mRNAs, along with various forms of transient post-translational modifications, and detecting each type of signaling molecule requires categorically different sample preparation methods such as Western blotting for proteins, PCR formore » nucleic acids, and flow cytometry for post-translational modifications. Since we know that cells in populations behave heterogeneously1, especially in the cases of stem cells, cancer, and hematopoiesis, there is need for a new technology that provides capability to detect and quantify multiple categories of signaling molecules in intact single cells to provide a comprehensive view of the cell’s physiological state. In this technical brief, we describe our microfluidic platform with a portfolio of customized molecular assays that can detect nucleic acids, proteins, and post-translational modifications in single intact cells with >95% reduction in reagent requirement in under 8 hours.« less

  2. Microfluidic molecular assay platform for the detection of miRNAs, mRNAs, proteins, and post-translational modifications at single-cell resolution

    SciTech Connect (OSTI)

    Wu, Meiye; Singh, Anup K.

    2014-07-15

    In this study, cell signaling is a dynamic and complex process. A typical signaling pathway may begin with activation of cell surface receptors, leading to activation kinase cascade that culminates in induction of mRNA and non-coding miRNA production in the nucleus, followed by modulation of mRNA expression by miRNAs in the cytosol, and end with production of proteins in response to the signaling pathway. Signaling pathways involve proteins, miRNA, and mRNAs, along with various forms of transient post-translational modifications, and detecting each type of signaling molecule requires categorically different sample preparation methods such as Western blotting for proteins, PCR for nucleic acids, and flow cytometry for post-translational modifications. Since we know that cells in populations behave heterogeneously1, especially in the cases of stem cells, cancer, and hematopoiesis, there is need for a new technology that provides capability to detect and quantify multiple categories of signaling molecules in intact single cells to provide a comprehensive view of the cell’s physiological state. In this technical brief, we describe our microfluidic platform with a portfolio of customized molecular assays that can detect nucleic acids, proteins, and post-translational modifications in single intact cells with >95% reduction in reagent requirement in under 8 hours.

  3. Characterizing the Range of Extracellular Protein Post-Translational Modifications in a Cellulose-Degrading Bacteria Using a Multiple Proteolyic Digestion/Peptide Fragmentation Approach

    SciTech Connect (OSTI)

    Dykstra, Andrew B; Rodriguez, Jr., Miguel; Raman, Babu; Cook, Kelsey; Hettich, Robert {Bob} L

    2013-01-01

    Post-translational modifications (PTMs) are known to play a significant role in many biological functions. The focus of this study is to characterize the post-translational modifications of the cellulosome protein complex used by the bacterium Clostridium thermocellum to better understand how this protein machine is tuned for enzymatic cellulose solubilization. To enhance comprehensive characterization, the extracellular cellulosome proteins were analyzed using multiple proteolytic digests (trypsin, Lys-C, Glu-C) and multiple fragmentation techniques (collisionally-activated dissociation, electron transfer dissociation, decision tree). As expected, peptide and protein identifications were increased by utilizing alternate proteases and fragmentation methods, in addition to the increase in protein sequence coverage. The complementarity of these experiments also allowed for a global exploration of PTMs associated with the cellulosome based upon a set of defined PTMs that included methylation, oxidation, acetylation, phosphorylation, and signal peptide cleavage. In these experiments, 85 modified peptides corresponding to 28 cellulosome proteins were identified. Many of these modifications were located in active cellulolytic or structural domains of the cellulosome proteins, suggesting a level of possible regulatory control of protein function in various cellulotyic conditions. The use of multiple enzymes and fragmentation technologies allowed for independent verification of PTMs in different experiments, thus leading to increased confidence in PTM identifications.

  4. Microfluidic Molecular Assay Platform for the Detection of miRNAs, mRNAs, Proteins, and Posttranslational Modifications at Single-Cell Resolution

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wu, Meiye; Singh, Anup K.

    2014-07-15

    Cell signaling is a dynamic and complex process. A typical signaling pathway may begin with activation of cell surface receptors, leading to activation kinase cascade that culminates in induction of mRNA and non-coding miRNA production in the nucleus, followed by modulation of mRNA expression by miRNAs in the cytosol, and end with production of proteins in response to the signaling pathway. Signaling pathways involve proteins, miRNA, and mRNAs, along with various forms of transient post-translational modifications, and detecting each type of signaling molecule requires categorically different sample preparation methods such as Western blotting for proteins, PCR for nucleic acids, andmoreflow cytometry for post-translational modifications. Since we know that cells in populations behave heterogeneously1, especially in the cases of stem cells, cancer, and hematopoiesis, there is need for a new technology that provides capability to detect and quantify multiple categories of signaling molecules in intact single cells to provide a comprehensive view of the cells physiological state. In this technical brief, we describe our microfluidic platform with a portfolio of customized molecular assays that can detect nucleic acids, proteins, and post-translational modifications in single intact cells with >95% reduction in reagent requirement in under 8 hours.less

  5. Hadronic form factors in kaon photoproduction

    SciTech Connect (OSTI)

    Syukurilla, L. Mart, T.

    2014-09-25

    We have revisited the effect of hadronic form factors in kaon photoproduction process by utilizing an isobaric model developed for kaon photoproduction off the proton. The model is able to reproduce the available experimental data nicely as well as to reveal the origin of the second peak in the total cross section, which was the main source of confusion for decades. Different from our previous study, in the present work we explore the possibility of using different hadronic form factors in each of the K?N vertices. The use of different hadronic form factors, e.g. dipole, Gaussian, and generalized dipole, has been found to produce a more flexible isobar model, which can provide a significant improvement in the model.

  6. Power-factor metering gains new interest

    SciTech Connect (OSTI)

    Womack, D.L.

    1980-01-01

    The combined effect of increased energy costs, advances in digital metering techniques, and regulatory pressures is stimulating utility interest in charging smaller customers the full cost of their burden on the electric system, by metering reactive power and billing for poor power factor. Oklahoma Gas and Electric Co. adopted the Q-meter method, made practical with the advent of magnetic-tape metering. Digital metering and new techniques now being developed will add more options for utilities interested in metering power factor. There are three commonly used methods of determining power factor, all of which require the use of the standard induction watthour meter, plus at least one other meter, to obtain a second value in the power triangle. In all cases, the third value, if required, is obtained by calculation.

  7. Measurement of the Helium Factors at Jlab

    SciTech Connect (OSTI)

    Elena Khrosinkova

    2007-06-11

    An experiment to measure elastic electron scattering off 3He and 4He at large momentum transfers is presented. The experiment was carried out in the Hall A Facility of Jefferson Lab. Elastic electron scattering off 3He was measured at forward and backward electron scattering angles to extract the isotope's charge and magnetic form factors. The charge form factor of 4He will be extracted from forward-angle electron scattering angle measurements. The data are expected to significantly extend and improve the existing measurements of the three-and four-body form factors. The results will be crucial for the establishment of a canonical standard model for the few- body nuclear systems and for testing predictions of quark dimensional scaling and hybrid nucleon- quark models.

  8. Human factors in nuclear technology - a history

    SciTech Connect (OSTI)

    Jones, D.B. )

    1992-01-01

    Human factors, human factors engineering (HFE), or ergonomics did not receive much formal attention in nuclear technology prior to the Three Mile Island Unit 2 (TMI-2) incident. Three principal reasons exist for this lack of concern. First, emerging technologies show little concern with how people will use a new system. Making the new technology work is considered more important than the people who will use it. Second, the culture of the users of nuclear power did not recognize a need for human factors. Traditional utilities had well established and effective engineering designs for control of electric power generation, while medicine considered the use of nuclear isotopes another useful tool, not requiring special ergonomics. Finally, the nuclear industry owed much to Admiral Rickover. He was definitely opposed.

  9. Chiral extrapolation of nucleon magnetic form factors

    SciTech Connect (OSTI)

    P. Wang; D. Leinweber; A. W. Thomas; R.Young

    2007-04-01

    The extrapolation of nucleon magnetic form factors calculated within lattice QCD is investigated within a framework based upon heavy baryon chiral effective-field theory. All one-loop graphs are considered at arbitrary momentum transfer and all octet and decuplet baryons are included in the intermediate states. Finite range regularization is applied to improve the convergence in the quark-mass expansion. At each value of the momentum transfer (Q{sup 2}), a separate extrapolation to the physical pion mass is carried out as a function of m{sub {pi}} alone. Because of the large values of Q{sup 2} involved, the role of the pion form factor in the standard pion-loop integrals is also investigated. The resulting values of the form factors at the physical pion mass are compared with experimental data as a function of Q{sup 2} and demonstrate the utility and accuracy of the chiral extrapolation methods presented herein.

  10. Communication-avoiding symmetric-indefinite factorization

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ballard, Grey Malone; Becker, Dulcenia; Demmel, James; Dongarra, Jack; Druinsky, Alex; Peled, Inon; Schwartz, Oded; Toledo, Sivan; Yamazaki, Ichitaro

    2014-11-13

    We describe and analyze a novel symmetric triangular factorization algorithm. The algorithm is essentially a block version of Aasen's triangular tridiagonalization. It factors a dense symmetric matrix A as the product A=PLTLTPT where P is a permutation matrix, L is lower triangular, and T is block tridiagonal and banded. The algorithm is the first symmetric-indefinite communication-avoiding factorization: it performs an asymptotically optimal amount of communication in a two-level memory hierarchy for almost any cache-line size. Adaptations of the algorithm to parallel computers are likely to be communication efficient as well; one such adaptation has been recently published. As a result,more » the current paper describes the algorithm, proves that it is numerically stable, and proves that it is communication optimal.« less

  11. Communication-avoiding symmetric-indefinite factorization

    SciTech Connect (OSTI)

    Ballard, Grey Malone; Becker, Dulcenia; Demmel, James; Dongarra, Jack; Druinsky, Alex; Peled, Inon; Schwartz, Oded; Toledo, Sivan; Yamazaki, Ichitaro

    2014-11-13

    We describe and analyze a novel symmetric triangular factorization algorithm. The algorithm is essentially a block version of Aasen's triangular tridiagonalization. It factors a dense symmetric matrix A as the product A=PLTLTPT where P is a permutation matrix, L is lower triangular, and T is block tridiagonal and banded. The algorithm is the first symmetric-indefinite communication-avoiding factorization: it performs an asymptotically optimal amount of communication in a two-level memory hierarchy for almost any cache-line size. Adaptations of the algorithm to parallel computers are likely to be communication efficient as well; one such adaptation has been recently published. As a result, the current paper describes the algorithm, proves that it is numerically stable, and proves that it is communication optimal.

  12. Human factors challenges for advanced process control

    SciTech Connect (OSTI)

    Stubler, W.F.; O`Hara, J..M.

    1996-08-01

    New human-system interface technologies provide opportunities for improving operator and plant performance. However, if these technologies are not properly implemented, they may introduce new challenges to performance and safety. This paper reports the results from a survey of human factors considerations that arise in the implementation of advanced human-system interface technologies in process control and other complex systems. General trends were identified for several areas based on a review of technical literature and a combination of interviews and site visits with process control organizations. Human factors considerations are discussed for two of these areas, automation and controls.

  13. Annotated bibliography of human factors applications literature

    SciTech Connect (OSTI)

    McCafferty, D.B.

    1984-09-30

    This bibliography was prepared as part of the Human Factors Technology Project, FY 1984, sponsored by the Office of Nuclear Safety, US Department of Energy. The project was conducted by Lawrence Livermore National Laboratory, with Essex Corporation as a subcontractor. The material presented here is a revision and expansion of the bibliographic material developed in FY 1982 as part of a previous Human Factors Technology Project. The previous bibliography was published September 30, 1982, as Attachment 1 to the FY 1982 Project Status Report.

  14. Meson-photon transition form factors

    SciTech Connect (OSTI)

    Balakireva, Irina; Lucha, Wolfgang; Melikhov, Dmitri

    2012-10-23

    We present the results of our recent analysis of the meson-photon transition form factors F{sub P{gamma}}(Q{sup 2}) for the pseudoscalar mesons P {pi}{sup 0},{eta},{eta} Prime ,{eta}{sub c}, using the local-duality version of QCD sum rules.

  15. Factors Affecting PMU Installation Costs (October 2014)

    Broader source: Energy.gov [DOE]

    The Department of Energy investigated the major cost factors that affected PMU installation costs for the synchrophasor projects funded through the Recovery Act Smart Grid Programs. The data was compiled through interviews with the nine projects that deployed production grade synchrophasor systems.

  16. Derivation of dose conversion factors for tritium

    SciTech Connect (OSTI)

    Killough, G. G.

    1982-03-01

    For a given intake mode (ingestion, inhalation, absorption through the skin), a dose conversion factor (DCF) is the committed dose equivalent to a specified organ of an individual per unit intake of a radionuclide. One also may consider the effective dose commitment per unit intake, which is a weighted average of organ-specific DCFs, with weights proportional to risks associated with stochastic radiation-induced fatal health effects, as defined by Publication 26 of the International Commission on Radiological Protection (ICRP). This report derives and tabulates organ-specific dose conversion factors and the effective dose commitment per unit intake of tritium. These factors are based on a steady-state model of hydrogen in the tissues of ICRP's Reference Man (ICRP Publication 23) and equilibrium of specific activities between body water and other tissues. The results differ by 27 to 33% from the estimate on which ICRP Publication 30 recommendations are based. The report also examines a dynamic model of tritium retention in body water, mineral bone, and two compartments representing organically-bound hydrogen. This model is compared with data from human subjects who were observed for extended periods. The manner of combining the dose conversion factors with measured or model-predicted levels of contamination in man's exposure media (air, drinking water, soil moisture) to estimate dose rate to an individual is briefly discussed.

  17. Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-{Delta}{sup 12,14}-prostaglandin J2

    SciTech Connect (OSTI)

    Mishra, Nandita; Kar, Rekha; Singha, Prajjal K.; Venkatachalam, Manjeri A.; Department of Biochemistry, UT Health Science Center at San Antonio, San Antonio, TX 78229 ; McEwen, Donald G.; Saikumar, Pothana

    2010-04-23

    Arachidonic acid derived endogenous electrophile 15d-PGJ2 has gained much attention in recent years due to its potent anti-proliferative and anti-inflammatory actions mediated through thiol modification of cysteine residues in its target proteins. Here, we show that 15d-PGJ2 at 1 {mu}M concentration converts normal mitochondria into large elongated and interconnected mitochondria through direct binding to mitochondrial fission protein Drp1 and partial inhibition of its GTPase activity. Mitochondrial elongation induced by 15d-PGJ2 is accompanied by increased assembly of Drp1 into large oligomeric complexes through plausible intermolecular interactions. The role of decreased GTPase activity of Drp1 in the formation of large oligomeric complexes is evident when Drp1 is incubated with a non-cleavable GTP analog, GTP{gamma}S or by a mutation that inactivated GTPase activity of Drp1 (K38A). The mutation of cysteine residue (Cys644) in the GTPase effector domain, a reported target for modification by reactive electrophiles, to alanine mimicked K38A mutation induced Drp1 oligomerization and mitochondrial elongation, suggesting the importance of cysteine in GED to regulate the GTPase activity and mitochondrial morphology. Interestingly, treatment of K38A and C644A mutants with 15d-PGJ2 resulted in super oligomerization of both mutant Drp1s indicating that 15d-PGJ2 may further stabilize Drp1 oligomers formed by loss of GTPase activity through covalent modification of middle domain cysteine residues. The present study documents for the first time the regulation of a mitochondrial fission activity by a prostaglandin, which will provide clues for understanding the pathological and physiological consequences of accumulation of reactive electrophiles during oxidative stress, inflammation and degeneration.

  18. Electron-phonon coupling modification and carrier mobility enhancement in poly(3,4-ethylenedioxythiophene) doped with poly(4-styrenesulfonate) films by ultraviolet irradiation

    SciTech Connect (OSTI)

    Lin, Yow-Jon Chin, Yi-Min; Wu, Cheng-You; Liu, Day-Shan

    2014-09-07

    The effect of ultraviolet irradiation on the electrical property of poly(3,4-ethylenedioxythiophene) doped with poly(4-styrenesulfonate) (PEDOT:PSS) films was examined. It is shown that the carrier mobility increases while the carrier density does not change substantially. The carrier mobility in PEDOT:PSS samples exhibits strong temperature dependence, indicating the dominance of tunneling (hopping) at low (high) temperatures. The results demonstrate that changes in the chemical structure may lead to the modification of the electron-phonon coupling, thus increasing the carrier mobility in PEDOT:PSS.

  19. A Modification of the Isotope Generation and Depletion Code System ORIGEN. CCC-702/ORIGEN-ARP is recommended for new ORIGEN users.

    Energy Science and Technology Software Center (OSTI)

    1984-05-04

    Version 00 KORIGEN is a modification of the isotope generation and depletion code system CCC-217/ORIGEN. ORIGEN solved the equations of radioactive growth and decay allowing continuous first order chemical processing and a neutron flux described by a three-region spectrum. Complex decay and transmutation schemes were treated. Note that this package has not been updated in many years; and all new ORIGEN users are advised to request the CCC-702/ORIGEN-ARP package, which is a PC application formore » Windows 95/NT or later.« less

  20. A Framework for Geometric Reasoning About Human Figures and Factors in Assembly Processes

    SciTech Connect (OSTI)

    Calton, Terri L.

    1999-07-20

    Automatic assembly sequencing and visualization tools are valuable in determining the best assembly sequences, but without Human Factors and Figure Models (HFFMs) it is difficult to evaluate or visualize human interaction. In industry, accelerating technological advances and shorter market windows have forced companies to turn to an agile manufacturing paradigm. This trend has promoted computerized automation of product design and manufacturing processes, such as automated assembly planning. However, all automated assembly planning software tools assume that the individual components fly into their assembled configuration and generate what appear to be perfectly valid operations, but in reality some operations cannot physically be carried out by a human. For example, the use of a ratchet may be reasoned feasible for an assembly operation; however, when a hand is placed on the tool the operation is no longer feasible, perhaps because of inaccessibility, insufficient strength or human interference with assembly components. Similarly, human figure modeling algorithms may indicate that assembly operations are not feasible and consequently force design modifications, however, if they had the capability to quickly generate alternative assembly sequences, they might have identified a feasible solution. To solve this problem, HFFMs must be integrated with automated assembly planning which allows engineers to quickly verify that assembly operations are possible and to see ways to make the designs even better. This paper presents a framework for integrating geometry-based assembly planning algorithms with commercially available human figure modeling software packages. Experimental results to selected applications along with lessons learned are presented.

  1. Module: Emission Factors for Deforestation | Open Energy Information

    Open Energy Info (EERE)

    www.leafasia.orgtoolstechnical-guidance-series-emission-factors-defo Cost: Free Language: English Module: Emission Factors for Deforestation Screenshot Logo: Module: Emission...

  2. Engineering an allosteric transcription factor to respond to...

    Office of Scientific and Technical Information (OSTI)

    Engineering an allosteric transcription factor to respond to new ligands Citation Details In-Document Search Title: Engineering an allosteric transcription factor to respond to new ...

  3. Test of factorization in diffractive deep inelastic scattering...

    Office of Scientific and Technical Information (OSTI)

    Test of factorization in diffractive deep inelastic scattering and photoproduction at HERA Citation Details In-Document Search Title: Test of factorization in diffractive deep ...

  4. Dense LU Factorization on Multicore Supercomputer Nodes (Conference...

    Office of Scientific and Technical Information (OSTI)

    factorization's memory hierarchy contention on now-ubiquitous multi-core architectures. ... During active panel factorization, rank-1 updates stream through memory with minimal ...

  5. Study of Factors Affecting Shrub Establishment on the Monticello...

    Office of Environmental Management (EM)

    Study of Factors Affecting Shrub Establishment on the Monticello, Utah, Disposal Cell Cover Study of Factors Affecting Shrub Establishment on the Monticello, Utah, Disposal Cell...

  6. Neutrino mass, dark energy, and the linear growth factor (Journal...

    Office of Scientific and Technical Information (OSTI)

    dark energy, and the linear growth factor Citation Details In-Document Search Title: Neutrino mass, dark energy, and the linear growth factor We study the degeneracies between ...

  7. Is the proton electromagnetic form factor modified in nuclei...

    Office of Scientific and Technical Information (OSTI)

    Is the proton electromagnetic form factor modified in nuclei? Citation Details In-Document Search Title: Is the proton electromagnetic form factor modified in nuclei? You are ...

  8. Method for determining formation quality factor from well log...

    Office of Scientific and Technical Information (OSTI)

    factor from well log data and its application to seismic reservoir characterization Citation Details In-Document Search Title: Method for determining formation quality factor ...

  9. Initiation factor 2 crystal structure reveals a different domain...

    Office of Scientific and Technical Information (OSTI)

    Initiation factor 2 crystal structure reveals a different domain organization from eukaryotic initiation factor 5B and mechanism among translational GTPases Citation Details ...

  10. Theory of factors limiting high gradient operation of warm acceleratin...

    Office of Scientific and Technical Information (OSTI)

    Theory of factors limiting high gradient operation of warm accelerating structures Citation Details In-Document Search Title: Theory of factors limiting high gradient operation of ...

  11. Crystal structure of elongation factor 4 bound to a clockwise...

    Office of Scientific and Technical Information (OSTI)

    Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome Citation Details In-Document Search Title: Crystal structure of elongation factor 4 bound to a ...

  12. First Climate formerly Factor Consulting | Open Energy Information

    Open Energy Info (EERE)

    First Climate formerly Factor Consulting Jump to: navigation, search Name: First Climate (formerly Factor Consulting) Place: Germany Sector: Carbon Product: Former Swiss-based...

  13. Research on Factors Relating to Density and Climate Change |...

    Open Energy Info (EERE)

    on Factors Relating to Density and Climate Change Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Research on Factors Relating to Density and Climate Change Agency...

  14. Human Factors Engineering Analysis Tool - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Factors Engineering Analysis Tool Software tool that enables easy and quick selection of applicable regulatory guidelines as starting point for human factors engineering ...

  15. HUMAN FACTORS GUIDANCE FOR CONTROL ROOM EVALUATION

    SciTech Connect (OSTI)

    OHARA,J.; BROWN,W.; STUBLER,W.; HIGGINS,J.; WACHTEL,J.; PERSENSKY,J.J.

    2000-07-30

    The Human-System Interface Design Review Guideline (NUREG-0700, Revision 1) was developed by the US Nuclear Regulatory Commission (NRC) to provide human factors guidance as a basis for the review of advanced human-system interface technologies. The guidance consists of three components: design review procedures, human factors engineering guidelines, and a software application to provide design review support called the ``Design Review Guideline.'' Since it was published in June 1996, Rev. 1 to NUREG-0700 has been used successfully by NRC staff, contractors and nuclear industry organizations, as well as by interested organizations outside the nuclear industry. The NRC has committed to the periodic update and improvement of the guidance to ensure that it remains a state-of-the-art design evaluation tool in the face of emerging and rapidly changing technology. This paper addresses the current research to update of NUREG-0700 based on the substantial work that has taken place since the publication of Revision 1.

  16. Understanding Hazardous Combustion Byproducts Reduces Factors Impacting

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Climate Change Hazardous Combustion Byproducts Reduces Factors Impacting Climate Change - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery

  17. Modifications to toxic CUG RNAs induce structural stability, rescue mis-splicing in a myotonic dystrophy cell model and reduce toxicity in a myotonic dystrophy zebrafish model

    SciTech Connect (OSTI)

    deLorimier, Elaine; Coonrod, Leslie A.; Copperman, Jeremy; Taber, Alex; Reister, Emily E.; Sharma, Kush; Todd, Peter K.; Guenza, Marina G.; Berglund, J. Andrew

    2014-10-10

    In this study, CUG repeat expansions in the 3' UTR of dystrophia myotonica protein kinase (DMPK) cause myotonic dystrophy type 1 (DM1). As RNA, these repeats elicit toxicity by sequestering splicing proteins, such as MBNL1, into proteinRNA aggregates. Structural studies demonstrate that CUG repeats can form A-form helices, suggesting that repeat secondary structure could be important in pathogenicity. To evaluate this hypothesis, we utilized structure-stabilizing RNA modifications pseudouridine (?) and 2'-O-methylation to determine if stabilization of CUG helical conformations affected toxicity. CUG repeats modified with ? or 2'-O-methyl groups exhibited enhanced structural stability and reduced affinity for MBNL1. Molecular dynamics and X-ray crystallography suggest a potential water-bridging mechanism for ?-mediated CUG repeat stabilization. ? modification of CUG repeats rescued mis-splicing in a DM1 cell model and prevented CUG repeat toxicity in zebrafish embryos. This study indicates that the structure of toxic RNAs has a significant role in controlling the onset of neuromuscular diseases.

  18. First-principles investigation of the electronic and Li-ion diffusion properties of LiFePO{sub 4} by sulfur surface modification

    SciTech Connect (OSTI)

    Xu, Guigui E-mail: zghuang@fjnu.edu.cn; Zhong, Kehua; Zhang, Jian-Min; Huang, Zhigao E-mail: zghuang@fjnu.edu.cn

    2014-08-14

    We present a first-principles calculation for the electronic and Li-ion diffusion properties of the LiFePO{sub 4} (010) surface modified by sulfur. The calculated formation energy indicates that the sulfur adsorption on the (010) surface of the LiFePO{sub 4} is energetically favored. Sulfur is found to form Fe-S bond with iron. A much narrower band gap (0.67 eV) of the sulfur surface-modified LiFePO{sub 4} [S-LiFePO{sub 4} (010)] is obtained, indicating the better electronic conductive properties. By the nudged elastic band method, our calculations show that the activation energy of Li ions diffusion along the one-dimensional channel on the surface can be effectively reduced by sulfur surface modification. In addition, the surface diffusion coefficient of S-LiFePO{sub 4} (010) is estimated to be about 10{sup −11} (cm{sup 2}/s) at room temperature, which implies that sulfur modification will give rise to a higher Li ion carrier mobility and enhanced electrochemical performance.

  19. Modifications to toxic CUG RNAs induce structural stability, rescue mis-splicing in a myotonic dystrophy cell model and reduce toxicity in a myotonic dystrophy zebrafish model

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    deLorimier, Elaine; Coonrod, Leslie A.; Copperman, Jeremy; Taber, Alex; Reister, Emily E.; Sharma, Kush; Todd, Peter K.; Guenza, Marina G.; Berglund, J. Andrew

    2014-10-10

    In this study, CUG repeat expansions in the 3' UTR of dystrophia myotonica protein kinase (DMPK) cause myotonic dystrophy type 1 (DM1). As RNA, these repeats elicit toxicity by sequestering splicing proteins, such as MBNL1, into protein–RNA aggregates. Structural studies demonstrate that CUG repeats can form A-form helices, suggesting that repeat secondary structure could be important in pathogenicity. To evaluate this hypothesis, we utilized structure-stabilizing RNA modifications pseudouridine (Ψ) and 2'-O-methylation to determine if stabilization of CUG helical conformations affected toxicity. CUG repeats modified with Ψ or 2'-O-methyl groups exhibited enhanced structural stability and reduced affinity for MBNL1. Molecular dynamicsmore » and X-ray crystallography suggest a potential water-bridging mechanism for Ψ-mediated CUG repeat stabilization. Ψ modification of CUG repeats rescued mis-splicing in a DM1 cell model and prevented CUG repeat toxicity in zebrafish embryos. This study indicates that the structure of toxic RNAs has a significant role in controlling the onset of neuromuscular diseases.« less

  20. Transcription factor-based biosensors for detecting dicarboxylic acids

    DOE Patents [OSTI]

    Dietrich, Jeffrey; Keasling, Jay

    2014-02-18

    The invention provides methods and compositions for detecting dicarboxylic acids using a transcription factor biosensor.

  1. Regulation of MDA-MB-231 cell proliferation by GSK-3? involves epigenetic modifications under high glucose conditions

    SciTech Connect (OSTI)

    Gupta, Chanchal; Kaur, Jasmine; Tikoo, Kulbhushan

    2014-05-15

    Hyperglycemia is a critical risk factor for development and progression of breast cancer. We have recently reported that high glucose induces phosphorylation of histone H3 at Ser 10 as well as de-phosphorylation of GSK-3? at Ser 9 in MDA-MB-231 cells. Here, we elucidate the mechanism underlying hyperglycemia-induced proliferation in MDA-MB-231 breast cancer cells. We provide evidence that hyperglycemia led to increased DNA methylation and DNMT1 expression in MDA-MB-231 cells. High glucose condition led to significant increase in the expression of PCNA, cyclin D1 and decrease in the expression of PTPN 12, p21 and PTEN. It also induced hypermethylation of DNA at the promoter region of PTPN 12, whereas hypomethylation at Vimentin and Snail. Silencing of GSK-3? by siRNA prevented histone H3 phosphorylation and reduced DNMT1 expression. We show that chromatin obtained after immunoprecipitation with phospho-histone H3 was hypermethylated under high glucose condition, which indicates a cross-talk between DNA methylation and histone H3 phosphorylation. ChIP-qPCR analysis revealed up-regulation of DNMT1 and metastatic genes viz. Vimentin, Snail and MMP-7 by phospho-histone H3, which were down-regulated upon GSK-3? silencing. To the best of our knowledge, this is the first report which shows that interplay between GSK-3? activation, histone H3 phosphorylation and DNA methylation directs proliferation of breast cancer cells. - Highlights: High glucose induces phosphorylation of histone H3 and dephosphorylation of GSK-3?. Moreover, hyperglycemia also leads to increased DNA methylation in MDA-MB-231 cells. Inhibition of GSK-3? prevented histone H3 phosphorylation and reduced DNMT1 levels. Interplay exists between GSK-3?, histone H3 phosphorylation and DNA methylation.

  2. The Role of Technology for Achieving Climate Policy Objectives: Overview of the EMF 27 Study on Technology Strategies and Climate Policy Scenarios

    SciTech Connect (OSTI)

    Kriegler, Elmar; Weyant, John; Blanford, Geoffrey J.; Krey, Volker; Clarke, Leon E.; Edmonds, James A.; Fawcett, Allen A.; Luderer, Gunnar; Riahi, Keywan; Richels, Richard G.; Rose, Steven; Tavoni, Massimo; Van Vuuren, Detlef

    2014-04-01

    This article presents the synthesis of results from the Stanford Energy Modeling Forum Study 27, an inter-comparison of 19 energy-economy and integrated assessment models. The study investigated the value of individual mitigation technologies such as energy intensity improvements, carbon capture and sequestration (CCS), nuclear power, solar and wind power and bioenergy for climate mitigation. Achieving atmospheric greenhouse gas concentration targets at 450 and 550 ppm CO2 equivalent requires massive greenhouse gas emissions reductions. A fragmented policy approach at the level of current ambition is inconsistent with these targets. The availability of a negative emissions technology, in most models biofuels with CCS, proved to be a key element for achieving the climate targets. Robust characteristics of the transformation of the energy system are increased energy intensity improvements and the electrification of energy end use coupled with a fast decarbonization of the electricity sector. Non-electric energy end use is hardest to decarbonize, particularly in the transport sector. Technology is a key element of climate mitigation. Versatile technologies such as CCS and bioenergy have largest value, due in part to their combined ability to produce negative emissions. The individual value of low-carbon power technologies is more limited due to the many alternatives in the sector. The scale of the energy transformation is larger for the 450 ppm than for the 550 ppm CO2e target. As a result, the achievability and the costs of the 450 ppm target are more sensitive to variations in technology variability. Mitigation costs roughly double when moving from 550 ppm to 450 ppm CO2e, but remain below 3% of GDP for most models.

  3. Electric and Magnetic Fields (EMF) RAPID Program Engineering Project 8: FINAL REPORT, Evaluation of Field Reduction Technologies, Volume 1 (Report) and Volume 2 (Appendices)

    SciTech Connect (OSTI)

    Commonwealth Associates, Inc.; IIT Research Institute

    1997-08-01

    This draft report consists of two volumes. Volume 1, the main body, contains an introducto~ sectionj an overview of magnetic fields sectio~ and field reduction technology evaluation section. Magnetic field reduction methods are evalpated for transmission lines, distribution Iines,sulxtations, building wiring applkmd machinery, and transportation systems. The evaluation considers effectiveness, co% and other ftiors. Volume 2 contains five appendices, Append~ A presents magnetic field shielding information. Appendices B and C present design assumptions and magnetic field plots for transmission and distribution lines, respectively. Appendices D and E present cost estimate details for transmission and distribution limes, respectively.

  4. Influence of a Modification of the Petcoke/Coal Ratio on the Leachability of Fly Ash and Slag Produced from a Large PCC Power Plant

    SciTech Connect (OSTI)

    Izquierdo,M.; Font, O.; Moreno, N.; Querol, X.; Huggins, F.; Alvarez, E.; Diez, S.; Otero, P.; Ballesteros, J.; Gimenez, A.

    2007-01-01

    Co-firing of coal with inexpensive secondary fuels such as petroleum coke is expected to increase in the near future in the EU given that it may provide certain economic and environmental benefits with respect to coal combustion. However, changes in the feed fuel composition of power plants may modify the bulk content and the speciation of a number of elements in fly ash and slag. Consequently, leachability of these byproducts also can be modified. This study is focused on identifying the changes in the environmental quality of co-fired fly ash and slag induced by a modification of the petcoke/coal ratio. Petcoke was found to increase the leachable content of V and Mo and to enhance the mobility of S and As. However, with the exception of these elements, the addition of this secondary fuel did not drastically modify the bulk composition or the overall leachability of the resulting fly ash and slag.

  5. Role of residual stresses in stress corrosion cracking in alloy 600 tubes. Part 1. Determination of throughwall residual stresses and their modification by transient heat treatment

    SciTech Connect (OSTI)

    Bandy, R.; Zemanian, T.

    1985-01-01

    The effect of transient heat treatment on throughwall residual stress distribution of cold worked Alloy 600 tubes has been investigated, using electrochemical machining coupled with Sachs analyses for residual stress calculations. Heating for 60 to 150 seconds at 775 to 850 C is used. Specimens are made from one highly cold worked and one lightly cold worked tube. In both cases significant reduction of the magnitude of the stress, and modification of the stress distribution are achieved as a result of the heat treatment. The percentage reduction of the magnitude of the stress caused by the same heat treatment is generally greater in the lightly cold worked tube than in the highly cold worked one. The implications of the stress relieving heat treatments to mitigating stress corrosion cracking in a specific case are discussed. 14 references, 17 figures, 1 table.

  6. Overview of recent studies and modifications being made to RHIC to mitigate the effects of a potential failure to the helium distribution system

    SciTech Connect (OSTI)

    Tuozzolo, J.; Bruno, D.; DiLieto, A.; Heppner, G.; Karol, R.; Lessard,E.; Liaw, C-J; McIntyre, G; Mi, C.; Reich, J.; Sandberg, J.; Seberg, S.; Smart, L.; Tallerico, T.; Theisen, C.; Todd, R.; Zapasek R.

    2011-03-28

    In order to cool the superconducting magnets in RHIC, its helium refrigerator distributes 4.5 K helium throughout the tunnel along with helium distribution for the magnet line recoolers, the heat shield, and the associated return lines. The worse case for failure would be a release from the magnet distribution line which operates at 3.5 to 4.5 atmospheres and contains the energized magnet but with a potential energy of 70 MJoules should the insulation system fail or an electrical connection opens. Studies were done to determine release rate of the helium and the resultant reduction in O{sub 2} concentration in the RHIC tunnel and service buildings. Equipment and components were also reviewed for design and reliability and modifications were made to reduce the likelihood of failure and to reduce the volume of helium that could be released.

  7. Persistent modification of Na{sub v}1.9 following chronic exposure to insecticides and pyridostigmine bromide

    SciTech Connect (OSTI)

    Nutter, Thomas J. Cooper, Brian Y.

    2014-06-15

    Many veterans of the 1991 Gulf War (GW) returned from that conflict with a widespread chronic pain affecting deep tissues. Recently, we have shown that a 60 day exposure to the insecticides permethrin, chlorpyrifos, and pyridostigmine bromide (NTPB) had little influence on nociceptor action potential forming Na{sub v}1.8, but increased K{sub v}7 mediated inhibitory currents 8 weeks after treatment. Using the same exposure regimen, we used whole cell patch methods to examine whether the influences of NTPB could be observed on Na{sub v}1.9 expressed in muscle and vascular nociceptors. During a 60 day exposure to NTPB, rats exhibited lowered muscle pain thresholds and increased rest periods, but these measures subsequently returned to normal levels. Eight and 12 weeks after treatments ceased, DRG neurons were excised from the sensory ganglia. Whole cell patch studies revealed little change in voltage dependent activation and deactivation of Na{sub v}1.9, but significant increases in the amplitude of Na{sub v}1.9 were observed 8 weeks after exposure. Cellular studies, at the 8 week delay, revealed that NTPB also significantly prolonged action potential duration and afterhyperpolarization (22 °C). Acute application of permethrin (10 μM) also increased the amplitude of Na{sub v}1.9 in skin, muscle and vascular nociceptors. In conclusion, chronic exposure to Gulf War agents produced long term changes in the amplitude of Na{sub v}1.9 expressed in muscle and vascular nociceptors. The reported increases in K{sub v}7 amplitude may have been an adaptive response to increased Na{sub v}1.9, and effectively suppressed behavioral pain measures in the post treatment period. Factors that alter the balance between Na{sub v}1.9 and K{sub v}7 could release spontaneous discharge and produce chronic deep tissue pain. - Highlights: • Rats were treated 60 days with permethrin, chlorpyrifos and pyridostigmine bromide. • 8 weeks after treatments, Nav1.9 activation and deactivation were

  8. c-Myc alters substrate utilization and O-GlcNAc protein posttranslational modifications without altering cardiac function during early aortic constriction

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ledee, Dolena; Smith, Lincoln; Bruce, Margaret; Kajimoto, Masaki; Isern, Nancy; Portman, Michael A.; Olson, Aaron K.; Bertrand, Luc

    2015-08-12

    Hypertrophic stimuli cause transcription of the proto-oncogene c-Myc (Myc). Prior work showed that myocardial knockout of c-Myc (Myc) attenuated hypertrophy and decreased expression of metabolic genes after aortic constriction. Accordingly, we assessed the interplay between Myc, substrate oxidation and cardiac function during early pressure overload hypertrophy. Mice with cardiac specific, inducible Myc knockout (MycKO-TAC) and non-transgenic littermates (Cont-TAC) were subjected to transverse aortic constriction (TAC; n = 7/group). Additional groups underwent sham surgery (Cont-Sham and MycKO-Sham, n = 5 per group). After two weeks, function was measured in isolated working hearts along with substrate fractional contributions to the citric acidmorecycle by using perfusate with C labeled mixed fatty acids, lactate, ketone bodies and unlabeled glucose and insulin. Cardiac function was similar between groups after TAC although +dP/dT and -dP/dT trended towards improvement in MycKO-TAC versus Cont-TAC. In sham hearts, Myc knockout did not affect cardiac function or substrate preferences for the citric acid cycle. However, Myc knockout altered fractional contributions during TAC. The unlabeled fractional contribution increased in MycKO-TAC versus Cont-TAC, whereas ketone and free fatty acid fractional contributions decreased. Additionally, protein posttranslational modifications by O-GlcNAc were significantly greater in Cont-TAC versus both Cont-Sham and MycKO-TAC. In conclusion, Myc alters substrate preferences for the citric acid cycle during early pressure overload hypertrophy without negatively affecting cardiac function. Myc also affects protein post-translational modifications by O-GlcNAc during hypertrophy, which may regulate Mycinduced metabolic changes.less

  9. c-Myc alters substrate utilization and O-GlcNAc protein posttranslational modifications without altering cardiac function during early aortic constriction

    SciTech Connect (OSTI)

    Ledee, Dolena; Smith, Lincoln; Bruce, Margaret; Kajimoto, Masaki; Isern, Nancy; Portman, Michael A.; Olson, Aaron K.; Bertrand, Luc

    2015-08-12

    Hypertrophic stimuli cause transcription of the proto-oncogene c-Myc (Myc). Prior work showed that myocardial knockout of c-Myc (Myc) attenuated hypertrophy and decreased expression of metabolic genes after aortic constriction. Accordingly, we assessed the interplay between Myc, substrate oxidation and cardiac function during early pressure overload hypertrophy. Mice with cardiac specific, inducible Myc knockout (MycKO-TAC) and non-transgenic littermates (Cont-TAC) were subjected to transverse aortic constriction (TAC; n = 7/group). Additional groups underwent sham surgery (Cont-Sham and MycKO-Sham, n = 5 per group). After two weeks, function was measured in isolated working hearts along with substrate fractional contributions to the citric acid cycle by using perfusate with C labeled mixed fatty acids, lactate, ketone bodies and unlabeled glucose and insulin. Cardiac function was similar between groups after TAC although +dP/dT and -dP/dT trended towards improvement in MycKO-TAC versus Cont-TAC. In sham hearts, Myc knockout did not affect cardiac function or substrate preferences for the citric acid cycle. However, Myc knockout altered fractional contributions during TAC. The unlabeled fractional contribution increased in MycKO-TAC versus Cont-TAC, whereas ketone and free fatty acid fractional contributions decreased. Additionally, protein posttranslational modifications by O-GlcNAc were significantly greater in Cont-TAC versus both Cont-Sham and MycKO-TAC. In conclusion, Myc alters substrate preferences for the citric acid cycle during early pressure overload hypertrophy without negatively affecting cardiac function. Myc also affects protein post-translational modifications by O-GlcNAc during hypertrophy, which may regulate Mycinduced metabolic changes.

  10. Synthesis, crystal structure, and properties of the rhombohedral modification of the thiospinel CuZr{sub 1.86(1)}S{sub 4}

    SciTech Connect (OSTI)

    Dong, Yongkwan; McGuire, Michael A.; Yun, Hoseop; DiSalvo, Francis J.

    2010-03-15

    The rhombohedral modification of the thiospinel, CuZr{sub 1.86(1)}S{sub 4}, has been synthesized by the reaction of the constituent elements in an alkali metal halide flux and structurally characterized by single crystal X-ray diffraction techniques. The title compound crystallizes in the rhombohedral space group D{sub 3d}{sup 5}-R3-barm (no. 166, a=7.3552(2) A, c=35.832(2) A, V=1678.76(13) A{sup 3}, Z=12, and R/wR=0.0239/0.0624). The structure is composed of close packed S layers, with a stacking order of ...ABCBCABABCACAB....along the c axis. The Zr and Cu atoms occupy the octahedral and tetrahedral holes between S layers, respectively. Three different kinds of S-M-S layers exist in the structure: layer I has fully occupied Zr and Cu sites, layer II has fully occupied Zr sites but no Cu, and layer III has partially occupied Zr and fully occupied Cu sites. Transport and optical properties indicate that the title compound is a small band gap (1.26 eV) n-type semiconductor. - Graphical abstract: The projected view of the rhombohedral modification, CuZr{sub 1.86(1)}S{sub 4}, down the [100] direction. Large letters denote the packing sequence of the S atoms (yellow circles) along the c axis. Zr (black circles) and Cu (red circles) atoms occupy the octahedral and tetrahedral holes, respectively, between close packed S layers.

  11. c-Myc alters substrate utilization and O-GlcNAc protein posttranslational modifications without altering cardiac function during early aortic constriction

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ledee, Dolena; Smith, Lincoln; Bruce, Margaret; Kajimoto, Masaki; Isern, Nancy; Portman, Michael A.; Olson, Aaron K.; Bertrand, Luc

    2015-08-12

    Pressure overload cardiac hypertrophy alters substrate metabolism. Prior work showed that myocardial inactivation of c-Myc (Myc) attenuated hypertrophy and decreased expression of metabolic genes after aortic constriction. Accordingly, we hypothesize that Myc regulates substrate preferences for the citric acid cycle during pressure overload hypertrophy from transverse aortic constriction (TAC) and that these metabolic changes impact cardiac function and growth. To test this hypothesis, we subjected mice with cardiac specific, inducible Myc inactivation (MycKO-TAC) and non-transgenic littermates (Cont-TAC) to transverse aortic constriction (TAC; n=7/group). A separate group underwent sham surgery (Sham, n=5). After two weeks, function was measured in isolated workingmore » hearts along with substrate fractional contributions to the citric acid cycle by using perfusate with 13C labeled mixed fatty acids, lactate, ketone bodies and unlabeled glucose and insulin. Cardiac function was similar between groups after TAC although +dP/dT and -dP/dT trended towards improvement in MycKO-TAC versus Cont-TAC. Compared to Sham, Cont-TAC had increased free fatty acid fractional contribution with a concurrent decrease in unlabeled (predominately glucose) contribution. The changes in free fatty acid and unlabeled fractional contributions were abrogated by Myc inactivation during TAC (MycKO-TAC). Additionally, protein posttranslational modification by O-GlcNAc was significantly greater in Cont-TAC versus both Sham and MycKO-TAC. Lastly, Myc alters substrate preferences for the citric acid cycle during early pressure overload hypertrophy without negatively affecting cardiac function. Myc also affects protein posttranslational modifications by O-GlcNAc during hypertrophy.« less

  12. c-Myc alters substrate utilization and O-GlcNAc protein posttranslational modifications without altering cardiac function during early aortic constriction

    SciTech Connect (OSTI)

    Ledee, Dolena; Smith, Lincoln; Bruce, Margaret; Kajimoto, Masaki; Isern, Nancy; Portman, Michael A.; Olson, Aaron K.; Bertrand, Luc

    2015-08-12

    Pressure overload cardiac hypertrophy alters substrate metabolism. Prior work showed that myocardial inactivation of c-Myc (Myc) attenuated hypertrophy and decreased expression of metabolic genes after aortic constriction. Accordingly, we hypothesize that Myc regulates substrate preferences for the citric acid cycle during pressure overload hypertrophy from transverse aortic constriction (TAC) and that these metabolic changes impact cardiac function and growth. To test this hypothesis, we subjected mice with cardiac specific, inducible Myc inactivation (MycKO-TAC) and non-transgenic littermates (Cont-TAC) to transverse aortic constriction (TAC; n=7/group). A separate group underwent sham surgery (Sham, n=5). After two weeks, function was measured in isolated working hearts along with substrate fractional contributions to the citric acid cycle by using perfusate with 13C labeled mixed fatty acids, lactate, ketone bodies and unlabeled glucose and insulin. Cardiac function was similar between groups after TAC although +dP/dT and -dP/dT trended towards improvement in MycKO-TAC versus Cont-TAC. Compared to Sham, Cont-TAC had increased free fatty acid fractional contribution with a concurrent decrease in unlabeled (predominately glucose) contribution. The changes in free fatty acid and unlabeled fractional contributions were abrogated by Myc inactivation during TAC (MycKO-TAC). Additionally, protein posttranslational modification by O-GlcNAc was significantly greater in Cont-TAC versus both Sham and MycKO-TAC. Lastly, Myc alters substrate preferences for the citric acid cycle during early pressure overload hypertrophy without negatively affecting cardiac function. Myc also affects protein posttranslational modifications by O-GlcNAc during hypertrophy.

  13. Improvement of Carbon Dioxide Sweep Efficiency by Utilization of Microbial Permeability Profile Modification to Reduce the Amount of Oil Bypassed During Carbon Dioxide Flood

    SciTech Connect (OSTI)

    Darrel Schmitz; Lewis Brown F. Leo Lynch; Brenda Kirkland; Krystal Collins; William Funderburk

    2010-12-31

    The objective of this project was to couple microbial permeability profile modification (MPPM), with carbon dioxide flooding to improve oil recovery from the Upper Cretaceous Little Creek Oil Field situated in Lincoln and Pike counties, MS. This study determined that MPPM technology, which improves production by utilizing environmentally friendly nutrient solutions to simulate the growth of the indigenous microflora in the most permeable zones of the reservoir thus diverting production to less permeable, previously unswept zones, increased oil production without interfering with the carbon dioxide flooding operation. Laboratory tests determined that no microorganisms were produced in formation waters, but were present in cores. Perhaps the single most significant contribution of this study is the demonstration that microorganisms are active at a formation temperature of 115?C (239?F) by using a specially designed culturing device. Laboratory tests were employed to simulate the MPPM process by demonstrating that microorganisms could be activated with the resulting production of oil in coreflood tests performed in the presence of carbon dioxide at 66?C (the highest temperature that could be employed in the coreflood facility). Geological assessment determined significant heterogeneity in the Eutaw Formation, and documented relatively thin, variably-lithified, well-laminated sandstone interbedded with heavily-bioturbated, clay-rich sandstone and shale. Live core samples of the Upper Cretaceous Eutaw Formation from the Heidelberg Field, MS were quantitatively assessed using SEM, and showed that during MPPM permeability modification occurs ubiquitously within pore and throat spaces of 10-20 ?m diameter. Testing of the MPPM procedure in the Little Creek Field showed a significant increase in production occurred in two of the five production test wells; furthermore, the decline curve in each of the production wells became noticeably less steep. This project greatly

  14. Investigating the reversibility of structural modifications of LixNiyMnzCo1-y-zO₂ cathode materials during initial charge/discharge, at multiple length scales

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hwang, Sooyeon; Bak, Seong -Min; Kim, Seung Min; Chung, Kyung Yoon; Chang, Wonyoung

    2015-08-11

    In this work, we investigate the structural modifications occurring at the bulk, subsurface, and surface scales of LixNiyMnzCo1-y-zO₂ (NMC; y, z = 0.8, 0.1 and 0.4, 0.3, respectively) cathode materials during the initial charge/discharge. Various analytical tools, such as X-ray diffraction, selected-area electron diffraction, electron energy-loss spectroscopy, and high-resolution electron microscopy, are used to examine the structural properties of the NMC cathode materials at the three different scales. Cut-off voltages of 4.3 and 4.8 V are applied during the electrochemical tests as the normal and extreme conditions, respectively. The high-Ni-content NMC cathode materials exhibit unusual behaviors, which is deviate frommore » the general redox reactions during the charge or discharge. The transition metal (TM) ions in the high-Ni-content NMC cathode materials, which are mostly Ni ions, are reduced at 4.8 V, even though TMs are usually oxidized to maintain charge neutrality upon the removal of Li. It was found that any changes in the crystallographic and electronic structures are mostly reversible down to the sub-surface scale, despite the unexpected reduction of Ni ions. However, after the discharge, traces of the phase transitions remain at the edges of the NMC cathode materials at the scale of a few nanometers (i.e., surface scale). This study demonstrates that the structural modifications in NMC cathode materials are induced by charge as well as discharge at multiple length scales. These changes are nearly reversible after the first cycle, except at the edges of the samples, which should be avoided because these highly localized changes can initiate battery degradation.« less

  15. c-Myc alters substrate utilization and O-GlcNAc protein posttranslational modifications without altering cardiac function during early aortic constriction

    SciTech Connect (OSTI)

    Ledee, Dolena R.; Smith, Lincoln; Bruce, Margaret; Kajimoto, Masaki; Isern, Nancy G.; Portman, Michael A.; Olson, Aaron

    2015-08-12

    Pressure overload cardiac hypertrophy alters substrate metabolism. Prior work showed that myocardial inactivation of c-Myc (Myc) attenuated hypertrophy and decreased expression of metabolic genes after aortic constriction. Accordingly, we hypothesize that Myc regulates substrate preferences for the citric acid cycle during pressure overload hypertrophy from transverse aortic constriction (TAC) and that these metabolic changes impact cardiac function and growth. To test this hypothesis, we subjected mice with cardiac specific, inducible Myc inactivation (MycKO-TAC) and non-transgenic littermates (Cont-TAC) to transverse aortic constriction (TAC; n=7/group). A separate group underwent sham surgery (Sham, n=5). After two weeks, function was measured in isolated working hearts along with substrate fractional contributions to the citric acid cycle by using perfusate with 13C labeled mixed fatty acids, lactate, ketone bodies and unlabeled glucose and insulin. Cardiac function was similar between groups after TAC although +dP/dT and -dP/dT trended towards improvement in MycKO-TAC versus Cont-TAC. Compared to Sham, Cont-TAC had increased free fatty acid fractional contribution with a concurrent decrease in unlabeled (predominately glucose) contribution. The changes in free fatty acid and unlabeled fractional contributions were abrogated by Myc inactivation during TAC (MycKO-TAC). Additionally, protein posttranslational modification by O-GlcNAc was significantly greater in Cont-TAC versus both Sham and MycKO-TAC. In conclusion, Myc alters substrate preferences for the citric acid cycle during early pressure overload hypertrophy without negatively affecting cardiac function. Myc also affects protein posttranslational modifications by O-GlcNAc during hypertrophy.

  16. Various factors affect coiled tubing limits

    SciTech Connect (OSTI)

    Yang, Y.S.

    1996-01-15

    Safety and reliability remain the primary concerns in coiled tubing operations. Factors affecting safety and reliability include corrosion, flexural bending, internal (or external) pressure and tension (or compression), and mechanical damage due to improper use. Such limits as coiled tubing fatigue, collapse, and buckling need to be understood to avoid disaster. With increased use of coiled tubing, operators will gain more experience. But at the same time, with further research and development of coiled tubing, the manufacturing quality will be improved and fatigue, collapse, and buckling models will become more mature, and eventually standard specifications will be available. This paper reviews the uses of coiled tubing and current research on mechanical behavior of said tubing. It also discusses several models used to help predict fatigue and failure levels.

  17. Chiral corrections to hyperon axial form factors

    SciTech Connect (OSTI)

    Jiang Fujiun; Tiburzi, B. C.

    2008-05-01

    We study the complete set of flavor-changing hyperon axial-current matrix elements at small momentum transfer. Using partially quenched heavy baryon chiral perturbation theory, we derive the chiral and momentum behavior of the axial and induced pseudoscalar form factors. The meson pole contributions to the latter posses a striking signal for chiral physics. We argue that the study of hyperon axial matrix elements enables a systematic lattice investigation of the efficacy of three-flavor chiral expansions in the baryon sector. This can be achieved by considering chiral corrections to SU(3) symmetry predictions, and their partially quenched generalizations. In particular, despite the presence of eight unknown low-energy constants, we are able to make next-to-leading order symmetry breaking predictions for two linear combinations of axial charges.

  18. Identification and Control of Factors that Affect EGR Cooler Fouling

    Broader source: Energy.gov [DOE]

    Key factors that cause exhaust gas recirculation cooler fouling were identified through extensive literature search and controlled experiment was devised to study the impact of a few key factors on deposition.

  19. Confinement and the safety factor profile

    SciTech Connect (OSTI)

    Batha, S.H.; Levinton, F.M.; Scott, S.D.

    1995-12-01

    The conjecture that the safety factor profile, q(r), controls the improvement in tokamak plasmas from poor confinement in the Low (L-) mode regime to improved confinement in the supershot regime has been tested in two experiments on the Tokamak Fusion Test Reactor (TFTR). First, helium was puffed into the beam-heated phase of a supershot discharge which induced a degradation from supershot to L-mode confinement in about 100 msec, far less than the current relaxation time. The q and shear profiles measured by a motional Stark effect polarimeter showed little change during the confinement degradation. Second, rapid current ramps in supershot plasmas altered the q profile, but were observed not to change significantly the energy confinement. Thus, enhanced confinement in supershot plasmas is not due to a particular q profile which has enhanced stability or transport properties. The discharges making a continuous transition between supershot and L-mode confinement were also used to test the critical-electron-temperature-gradient transport model. It was found that this model could not reproduce the large changes in electron and ion temperature caused by the change in confinement.

  20. Accessing conjugated polymers with precisely controlled heterobisfunctional chain ends via post-polymerization modification of the OTf group and controlled Pd(0)/t-Bu3P-catalyzed Suzuki cross-coupling polymerization

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hu, Qiao -Sheng; Hong, Kunlun; Zhang, Hong -Hai

    2015-08-12

    In this study, a general strategy toward the synthesis of well-defined conjugated polymers with controlled heterobisfunctional chain ends via combination of controlled Pd(0)/t-Bu3P Suzuki cross-coupling polymerization with the post-polymerization modification of the triflate (OTf) group was disclosed.

  1. LPS-inducible factor(s) from activated macrophages mediates cytolysis of Naegleria fowleri amoebae

    SciTech Connect (OSTI)

    Cleary, S.F.; Marciano-Cabral, F.

    1986-03-01

    Soluble cytolytic factors of macrophage origin have previously been described with respect to their tumoricidal activity. The purpose of this study was to investigate the mechanism and possible factor(s) responsible for cytolysis of the amoeba Naegleria fowleri by activated peritoneal macrophages from B6C3F1 mice. Macrophages or conditioned medium (CM) from macrophage cultures were incubated with /sup 3/H-Uridine labeled amoebae. Percent specific release of label served as an index of cytolysis. Bacille Calmette-Guerin (BCG) and Corynebacterium parvum macrophages demonstrated significant cytolysis of amoebae at 24 h with an effector to target ratio of 10:1. Treatment of macrophages with inhibitors of RNA or protein synthesis blocked amoebicidal activity. Interposition of a 1 ..mu..m pore membrane between macrophages and amoebae inhibited killing. Inhibition in the presence of the membrane was overcome by stimulating the macrophages with LPS. CM from SPS-stimulated, but not unstimulated, cultures of activated macrophages was cytotoxic for amoebae. The activity was heat sensitive and was recovered from ammonium sulfate precipitation of the CM. Results indicate that amoebicidal activity is mediated by a protein(s) of macrophage origin induced by target cell contact or stimulation with LPS.

  2. Nominal Performance Biosphere Dose Conversion Factor Analysis

    SciTech Connect (OSTI)

    Wasiolek, Maryla A.

    2000-12-21

    The purpose of this report was to document the process leading to development of the Biosphere Dose Conversion Factors (BDCFs) for the postclosure nominal performance of the potential repository at Yucca Mountain. BDCF calculations concerned twenty-four radionuclides. This selection included sixteen radionuclides that may be significant nominal performance dose contributors during the compliance period of up to 10,000 years, five additional radionuclides of importance for up to 1 million years postclosure, and three relatively short-lived radionuclides important for the human intrusion scenario. Consideration of radionuclide buildup in soil caused by previous irrigation with contaminated groundwater was taken into account in the BDCF development. The effect of climate evolution, from the current arid conditions to a wetter and cooler climate, on the BDCF values was evaluated. The analysis included consideration of different exposure pathway's contribution to the BDCFs. Calculations of nominal performance BDCFs used the GENII-S computer code in a series of probabilistic realizations to propagate the uncertainties of input parameters into the output. BDCFs for the nominal performance, when combined with the concentrations of radionuclides in groundwater allow calculation of potential radiation doses to the receptor of interest. Calculated estimates of radionuclide concentration in groundwater result from the saturated zone modeling. The integration of the biosphere modeling results (BDCFs) with the outcomes of the other component models is accomplished in the Total System Performance Assessment (TSPA) to calculate doses to the receptor of interest from radionuclides postulated to be released to the environment from the potential repository at Yucca Mountain.

  3. THE RELATIVISTIC HEAVY ION COLLIDER (RHIC) CRYOGENIC SYSTEM AT BNL: REVIEW OF THE MODIFICATIONS AND UPGRADES SINCE 2002 AND PLANNED IMPROVEMENTS.

    SciTech Connect (OSTI)

    THAN,Y.R.; TUOZZOLO, J.; SIDI-YAKHLEF, A.; GANNI, V.; KNUDSEN, P.; ARENIUS, D.

    2007-07-16

    Brookhaven National Laboratory continues its multi-year program to improve the operational efficiency, reliability, and stability of the cryogenic system which also resulted in improved beam availability of the Relativistic Heavy Ion Collider (RHIC). This paper summarizes the work and changes made after each phase over the past four years to the present, as well as proposed future improvements. Power usage dropped from an initial 9.4 MW to the present 5.1 MW and is expected to drop below 5 MW after the completion of the remaining proposed improvements. The work proceeded in phases by balancing the Collider's schedule of operation, time required for the modifications and budget constraints. The main changes include process control, compressor oil removal and management, elimination of the use of cold compressors and two liquid helium storage tanks, insulation of the third liquid helium storage tank, compressor bypass flow reduction and the addition of a load turbine (Joule-Thompson expander) with associated heat exchangers at the cold end of the plant. Also, liquid helium pumps used for forced circulation of the sub-cooled helium through the magnet loops were eliminated by an accelerator supply flow reconfiguration. Planned future upgrades include the resizing of expanders 5 and 6 to increase their efficiencies.

  4. Modification of jet shapes in PbPb collisions at sqrt(s{NN}) equals 2.76 TeV

    SciTech Connect (OSTI)

    Chatrchyan, Serguei; et al,

    2014-03-01

    The first measurement of jet shapes, defined as the fractional transverse momentum radial distribution, for inclusive jets produced in heavy-ion collisions is presented. Data samples of PbPb and pp collisions, corresponding to integrated luminosities of 150 inverse microbarns and 5.3 inverse picobarns respectively, were collected at a nucleon-nucleon centre-of-mass energy of sqrt(s[NN]) = 2.76 TeV with the CMS detector at the LHC. The jets are reconstructed with the anti-kt algorithm with a distance parameter R=0.3, and the jet shapes are measured for charged particles with transverse momentum pt> 1 GeV. The jet shapes measured in PbPb collisions in different collision centralities are compared to reference distributions based on the pp data. A centrality-dependent modification of the jet shapes is observed in the more central PbPb collisions, indicating a redistribution of the energy inside the jet cone. This measurement provides information about the parton shower mechanism in the hot and dense medium produced in heavy-ion collisions.

  5. Influence of a modification of the petcoke/coal ratio on the leachability of fly ash and slag produced from a large PCC power plant

    SciTech Connect (OSTI)

    Maria Izquierdo; Oriol Font; Natalia Moreno

    2007-08-01

    Co-firing of coal with inexpensive secondary fuels such as petroleum coke is expected to increase in the near future in the EU given that it may provide certain economic and environmental benefits with respect to coal combustion. However, changes in the feed fuel composition of power plants may modify the bulk content and the speciation of a number of elements in fly ash and slag. Consequently, leachability of these byproducts also can be modified. This study is focused on identifying the changes in the environmental quality of co-fired fly ash and slag induced by a modification of the petcoke/coal ratio. Petcoke was found to increase the leachable content of V and Mo and to enhance the mobility of S and As. However, with the exception of these elements, the addition of this secondary fuel did not drastically modify the bulk composition or the overall leachability of the resulting fly ash and slag. 30 refs., 3 figs., 2 tabs.

  6. Analysis of alternative modifications for reducing backwater flooding at the Honey Creek coal strip-mine reclamation site in Henry County, Missouri. Water Resources Investigation

    SciTech Connect (OSTI)

    Alexander, T.W.

    1990-01-01

    Studies to determine the hydrologic conditions in mined and reclaimed mine areas, as well as areas of proposed mining, have become necessary with the enactment of the Surface Mining Control and Reclamation Act of 1977. Honey Creek in Henry County, Missouri, has been re-routed to flow through a series of former strip mining pits which lie within the Honey Creek coal strip mine reclamation site. During intense or long duration rainfalls within the Honey Creek basin, surface runoff has caused flooding on agricultural land near the upstream boundary of the reclamation site. The calculated existing design discharge (3,050 cubic feet per second) water-surface profile is compared to the expected water-surface profiles from three assumed alternative channel modifcations within the Honey Creek study area. The alternative channel modifications used in these analyses include (1) improvement of channel bottom slope, (2) relocation of spoil material, and (3) improved by-pass channel flow conditions. The alternative 1, 2, and 3 design discharge increase will reduce the agricultural field current (1990) frequency of backwater flooding from a 3-year to a 6.5-year event.

  7. Synthesis, Crystal Structure, and Properties of the Rhomboheral Modification of the Thiospinel CuZr1.86(1)S4

    SciTech Connect (OSTI)

    Dong, Yongkwan; McGuire, Michael A; Hoseop, Yun; DiSalvo, Francis J.

    2009-01-01

    The rhombohedral modification of the thiospinel, CuZr{sub 1.86(1)}S{sub 4}, has been synthesized by the reaction of the constituent elements in an alkali metal halide flux and structurally characterized by single crystal X-ray diffraction techniques. The title compound crystallizes in the rhombohedral space group D{sub 3d}{sup 5}-R{bar 3}m (166, a=7.3552(2) {angstrom}, c=35.832(2) {angstrom}, V=1678.76(13) {angstrom}{sup 3}, Z=12, and R/wR=0.0239/0.0624). The structure is composed of close packed S layers, with a stacking order of ABCBCABABCACAB along the c axis. The Zr and Cu atoms occupy the octahedral and tetrahedral holes between S layers, respectively. Three different kinds of S-M-S layers exist in the structure: layer I has fully occupied Zr and Cu sites, layer II has fully occupied Zr sites but no Cu, and layer III has partially occupied Zr and fully occupied Cu sites. Transport and optical properties indicate that the title compound is a small band gap (1.26 eV) n-type semiconductor.

  8. Acceptance for Beneficial Use for the 100K Service Water Pumps Auto Start Modifications Project 1K-97-3466M

    SciTech Connect (OSTI)

    MULLER, F.J.

    2000-03-27

    This Acceptance for Beneficial Use checklist covers the modifications to the K Basins service water pumps that added an auto-start function for reliability of the fire suppression system. The following information is to document the Acceptance for Beneficial Use (ABU) with a checklist and supporting information. The service water pumps have been modified so that on low system pressure after a time delay, the standby pump will automatically start. This ABU checklist matrix indicates the organizations that are responsible for the preparation of --or for the provision of input to--the identified documentation required by K Basins Operations. Looking at the items in the matrix, it can be seen that the subproject does not bear the sole responsibility for the generation of all these items. Rather, many items are outside of the subproject's scope such that other Spent Nuclear Fuel (SNF) organizations are needed to prepare or perform them (e.g., Training, Procedures, Facility Engineering, Startup, etc.). This supporting document, by virtue of all signatures approving it on the Engineering Data Transmittal, documents an agreement among the various represented disciplines and organizations within the SNF Project as to what is required in terms of documentation to transfer custody to Operations.

  9. Highly transparent conductive electrode with ultra-low HAZE by grain boundary modification of aqueous solution fabricated alumina-doped zinc oxide nanocrystals

    SciTech Connect (OSTI)

    Nian, Qiong; Cheng, Gary J.; Callahan, Michael; Bailey, John; Look, David; Efstathiadis, Harry

    2015-06-01

    Commercial production of transparent conducting oxide (TCO) polycrystalline films requires high electrical conductivity with minimal degradation in optical transparency. Aqueous solution deposited TCO films would reduce production costs of TCO films but suffer from low electrical mobility, which severely degrades both electrical conductivity and optical transparency in the visible spectrum. Here, we demonstrated that grain boundary modification by ultra-violet laser crystallization (UVLC) of solution deposited aluminium-doped zinc oxide (AZO) nanocrystals results in high Hall mobility, with a corresponding dramatic improvement in AZO electrical conductance. The AZO films after laser irradiation exhibit electrical mobility up to 18.1 cm{sup 2} V{sup −1} s{sup −1} with corresponding electrical resistivity and sheet resistances as low as 1 × 10{sup −3} Ω cm and 75 Ω/sq, respectively. The high mobility also enabled a high transmittance (T) of 88%-96% at 550 nm for the UVLC films. In addition, HAZE measurement shows AZO film scattering transmittance as low as 1.8%, which is superior over most other solution deposited transparent electrode alternatives such as silver nanowires. Thus, AZO films produced by the UVLC technique have a combined figure of merit for electrical conductivity, optical transparency, and optical HAZE higher than other solution based deposition techniques and comparable to vacuumed based deposition methods.

  10. Dose factor entry and display tool for BNCT radiotherapy

    DOE Patents [OSTI]

    Wessol, Daniel E.; Wheeler, Floyd J.; Cook, Jeremy L.

    1999-01-01

    A system for use in Boron Neutron Capture Therapy (BNCT) radiotherapy planning where a biological distribution is calculated using a combination of conversion factors and a previously calculated physical distribution. Conversion factors are presented in a graphical spreadsheet so that a planner can easily view and modify the conversion factors. For radiotherapy in multi-component modalities, such as Fast-Neutron and BNCT, it is necessary to combine each conversion factor component to form an effective dose which is used in radiotherapy planning and evaluation. The Dose Factor Entry and Display System is designed to facilitate planner entry of appropriate conversion factors in a straightforward manner for each component. The effective isodose is then immediately computed and displayed over the appropriate background (e.g. digitized image).

  11. Major Risk Factors to the Integrated Facility Disposition Project |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy to the Integrated Facility Disposition Project Major Risk Factors to the Integrated Facility Disposition Project The scope of the Integrated Facility Disposition Project (IFDP) needs to comprehensively address a wide range of environmental management risks at the Oak Ridge Reservation (ORO). Major Risk Factors to the Integrated Facility Disposition Project (227.35 KB) More Documents & Publications Major Risk Factors Integrated Facility Disposition Project - Oak Ridge

  12. Fragmentation, NRQCD and Factorization in Heavy Quarkonium Production...

    Office of Scientific and Technical Information (OSTI)

    However, we show that gauge invariance and factorization require that conventional NRQCD production matrix elements be modified to include Wilson lines or non-abelian gauge links. ...

  13. Electromagnetic form factors and the hypercentral constituent quark model

    SciTech Connect (OSTI)

    Sanctis, M. De; Giannini, M. M.; Santopinto, E.; Vassallo, A.

    2007-12-15

    We present new results concerning the electromagnetic form factors of the nucleon using a relativistic version of the hypercentral constituent quark model and a relativistic current.

  14. A Compendium of Transfer Factors for Agricultural and Animal...

    Office of Scientific and Technical Information (OSTI)

    Tables of transfer factors are listed by element and information source for beef, eggs, fish, fruit, grain, leafy vegetation, milk, poultry, and root vegetables. Authors: Staven, ...

  15. Analytical evaluation of atomic form factors: Application to Rayleigh scattering

    SciTech Connect (OSTI)

    Safari, L.; Santos, J. P.; Amaro, P.; Jnkl, K.; Fratini, F.

    2015-05-15

    Atomic form factors are widely used for the characterization of targets and specimens, from crystallography to biology. By using recent mathematical results, here we derive an analytical expression for the atomic form factor within the independent particle model constructed from nonrelativistic screened hydrogenic wave functions. The range of validity of this analytical expression is checked by comparing the analytically obtained form factors with the ones obtained within the Hartee-Fock method. As an example, we apply our analytical expression for the atomic form factor to evaluate the differential cross section for Rayleigh scattering off neutral atoms.

  16. Factors Affecting Power Output by Photovoltaic Cells Lesson

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Factors Affecting Power Output by Photovoltaic Cells Grade Level(s): IB 2 (Senior - 3 ... C.8 Photovoltaic cells and dye-sensitized solar cells (DSSC) Understandings: * Solar ...

  17. Development of the Electricity Carbon Emission Factors for Russia...

    Open Energy Info (EERE)

    Russia Jump to: navigation, search Name Development of the Electricity Carbon Emission Factors for Russia AgencyCompany Organization European Bank for Reconstruction and...

  18. EPA Rainfall Erosivity Factor Calculator Website | Open Energy...

    Open Energy Info (EERE)

    Calculator Website Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: EPA Rainfall Erosivity Factor Calculator Website Abstract This website allows...

  19. EPA - Rainfall Erosivity Factor Calculator webpage | Open Energy...

    Open Energy Info (EERE)

    Not Provided DOI Not Provided Check for DOI availability: http:crossref.org Online Internet link for EPA - Rainfall Erosivity Factor Calculator webpage Citation Environmental...

  20. Critical Factors Driving the High Volumetric Uptake of Methane...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Critical Factors Driving the High Volumetric Uptake of Methane in Cu-3(btc)(2) Previous Next List Hulvey, Zeric; Vlaisavljevich, Bess; Mason, Jarad A.; Tsivion, Ehud; Dougherty,...