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Sample records for minas gerais cemig

  1. Companhia Energetica de Minas Gerais Cemig | Open Energy Information

    Open Energy Info (EERE)

    de Minas Gerais (Cemig) Place: Belo Horizonte, Minas Gerais, Brazil Sector: Biomass, Efficiency, Hydro, Hydrogen, Solar, Wind energy Product: String representation "Electric...

  2. Women @ Energy: Mina Bissell | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Mina Bissell Women @ Energy: Mina Bissell March 13, 2013 - 4:49pm Addthis Dr. Mina Bissell has been recognized for her lifetime contributions to the fields of breast cancer research, the enhanced role of extracellular matrix (ECM) and the nucleus environment to gene expression in normal and malignant tissues. Dr. Mina Bissell has been recognized for her lifetime contributions to the fields of breast cancer research, the enhanced role of extracellular matrix (ECM) and the nucleus environment to

  3. Siamig Sinda car | Open Energy Information

    Open Energy Info (EERE)

    Siamig Sinda car Jump to: navigation, search Name: Siamig-Sindacar Place: Minas Gerais, Brazil Product: Sugar industry union active in the Brazilian state of Minas Gerais....

  4. Usina Santo Angelo USA | Open Energy Information

    Open Energy Info (EERE)

    Santo Angelo USA Jump to: navigation, search Name: Usina Santo Angelo (USA) Place: Pirajuba, Minas Gerais, Brazil Product: Minas Gerais-based ethanol and energy producer company....

  5. Bem Brasil Alimentos Ltda | Open Energy Information

    Open Energy Info (EERE)

    Bem Brasil Alimentos Ltda Jump to: navigation, search Name: Bem Brasil Alimentos Ltda Place: Araxa, Minas Gerais, Brazil Zip: 38181-419 Sector: Biomass Product: Minas Gerais based...

  6. Total Agroindustria Canavieira S A | Open Energy Information

    Open Energy Info (EERE)

    Agroindustria Canavieira S A Jump to: navigation, search Name: Total Agroindustria Canavieira SA Place: Bambui, Minas Gerais, Brazil Product: Ethanol producer in Minas Gerais,...

  7. Usina Mendonca | Open Energy Information

    Open Energy Info (EERE)

    Jump to: navigation, search Name: Usina Mendonca Place: Conquista, Minas Gerais, Brazil Product: Brazil based sugar producer located in the state of Minas Gerais....

  8. Destilaria Veredas | Open Energy Information

    Open Energy Info (EERE)

    to: navigation, search Name: Destilaria Veredas Place: Joao Pinheiro, Minas Gerais, Brazil Product: Brazil based ethanol producer located in Joao Pinheiro, Minas Gerais....

  9. Wanerg Energetica Ltda | Open Energy Information

    Open Energy Info (EERE)

    Place: Belo Horizonte, Minas Gerais, Brazil Sector: Hydro Product: Minas Gerais based small hydro developer. References: Wanerg Energetica Ltda.1 This article is a stub. You...

  10. Destilaria WD | Open Energy Information

    Open Energy Info (EERE)

    WD Jump to: navigation, search Name: Destilaria WD Place: Joao Pinheiro, Minas Gerais, Brazil Zip: 38022-290 Product: Brazil based ethanol producer located in Joao Pinheiro, Minas...

  11. Agropeu | Open Energy Information

    Open Energy Info (EERE)

    Agropeu Jump to: navigation, search Name: Agropeu Place: Pompeu, Minas Gerais, Brazil Zip: 35640 000 Product: Privately-owned Brazil based ethanol producer, located in Minas...

  12. Guanh es Energia S A | Open Energy Information

    Open Energy Info (EERE)

    Guanh es Energia S A Jump to: navigation, search Name: Guanhes Energia S.A. Place: Belo Horizonte, Minas Gerais, Brazil Zip: 30140-000 Sector: Hydro Product: Minas Gerais-SPV...

  13. Peixe Energia SA | Open Energy Information

    Open Energy Info (EERE)

    Peixe Energia SA Jump to: navigation, search Name: Peixe Energia SA Place: Minas Gerais, Brazil Sector: Hydro Product: Minas Gerais-based SPV company to develop small hydro plants....

  14. Luzboa SA | Open Energy Information

    Open Energy Info (EERE)

    SA Place: Belo Horizonte, Minas Gerais, Brazil Sector: Hydro Product: Minas Gerais-based small hydro developer. References: Luzboa SA1 This article is a stub. You can help...

  15. Grupo Araguari | Open Energy Information

    Open Energy Info (EERE)

    navigation, search Name: Grupo Araguari Place: Araguari, Minas Gerais, Brazil Product: Ethanol producer based in the Brazilian state of Minas Gerias that is building a 230mLpa...

  16. Usina Alvorada Acucar e Alcool | Open Energy Information

    Open Energy Info (EERE)

    Alvorada Acucar e Alcool Jump to: navigation, search Name: Usina Alvorada Acucar e Alcool Place: Arapora, Minas Gerais, Brazil Product: Ethanol Producer References: Usina Alvorada...

  17. Destilaria Rio Grande | Open Energy Information

    Open Energy Info (EERE)

    to: navigation, search Name: Destilaria Rio Grande Place: Fronteira, Minas Gerais, Brazil Zip: 38230-000 Product: Brazil based ethanol producer. References: Destilaria Rio...

  18. Dasa | Open Energy Information

    Open Energy Info (EERE)

    search Name: Dasa Place: Serra dos Aimors, Brazil Zip: Cep: 39868-000 Product: Ethanol distillery located in the state of Minas Gerais currently developing a project to...

  19. Vale do Ivai | Open Energy Information

    Open Energy Info (EERE)

    Place: So Pedro do Iva-, Parana, Brazil Zip: 86945-000 Product: Brazil based ethanol producer, which owns three ethanol plants in Paran and Minas Gerais. References:...

  20. Paro group | Open Energy Information

    Open Energy Info (EERE)

    Paro group Jump to: navigation, search Name: Paro group Place: Brazil Product: Ethanol producer that plans to jointly own an ethanol plant in Minas Gerais. References: Paro...

  1. Fusermann | Open Energy Information

    Open Energy Info (EERE)

    search Name: Fusermann Place: Minas Gerais, Brazil Product: Brazilian-based biodiesel producer. References: Fusermann1 This article is a stub. You can help OpenEI by...

  2. Biominas | Open Energy Information

    Open Energy Info (EERE)

    to: navigation, search Name: Biominas Place: Araxa, Minas Gerais, Brazil Product: Biodiesel producer Coordinates: -19.594213, -46.940944 Show Map Loading map......

  3. Biodiesel Triangulo | Open Energy Information

    Open Energy Info (EERE)

    Triangulo Jump to: navigation, search Name: Biodiesel Triangulo Place: Iturama, MG, Brazil Product: Brazilian biodiesel producer located in Minas Gerais will develop two biodiesel...

  4. Santa Maria Energetica | Open Energy Information

    Open Energy Info (EERE)

    Maria Energetica Jump to: navigation, search Name: Santa Maria Energetica Place: Brazil Sector: Hydro Product: Small-hydro developerbased in Minas Gerais. References: Santa Maria...

  5. Grupo Plantar | Open Energy Information

    Open Energy Info (EERE)

    Plantar Jump to: navigation, search Name: Grupo Plantar Place: Gutierrez, Minas Gerais, Brazil Product: Brazil-based forestry developer that runs a pig iron production plant on...

  6. Destilaria Planalto | Open Energy Information

    Open Energy Info (EERE)

    search Name: Destilaria Planalto Place: Ibia, Minas Gerais, Brazil Product: Ethanol producer References: Destilaria Planalto1 This article is a stub. You can help...

  7. Bio Octane Energias Renov veis | Open Energy Information

    Open Energy Info (EERE)

    Octane Energias Renov veis Jump to: navigation, search Name: Bio-Octane Energias Renovveis Place: Minas Gerais, Brazil Product: Brazil-based biodiesel producer, located in the...

  8. Sada Bio Energia e Agricultura | Open Energy Information

    Open Energy Info (EERE)

    Sada Bio Energia e Agricultura Jump to: navigation, search Name: Sada Bio-Energia e Agricultura Place: Jaiba, Minas Gerais, Brazil Sector: Biomass Product: This company is an...

  9. Cachoeira do Brumado Energia El trica Ltda | Open Energy Information

    Open Energy Info (EERE)

    do Brumado Energia El trica Ltda Jump to: navigation, search Name: Cachoeira do Brumado Energia Eltrica Ltda. Place: Matias Barbosa, Minas Gerais, Brazil Sector: Hydro Product:...

  10. Comosa S A | Open Energy Information

    Open Energy Info (EERE)

    Comosa S A Jump to: navigation, search Name: Comosa SA Place: Brazil Sector: Hydro Product: Small hydro developer and formed by Triton and Minas Gerais investors. References:...

  11. Mundus Carbo | Open Energy Information

    Open Energy Info (EERE)

    Minas Gerais, Brazil Zip: 30320-690 Sector: Services Product: Belo Horizonte-based environmental advisory company that focuses on services relating to climate change and...

  12. Destilaria Alpha | Open Energy Information

    Open Energy Info (EERE)

    Alpha Jump to: navigation, search Name: Destilaria Alpha Place: Claudio, Minas Gerais, Brazil Product: Brazil based ethanol producer. References: Destilaria Alpha1 This article...

  13. Abdiesel | Open Energy Information

    Open Energy Info (EERE)

    Abdiesel Jump to: navigation, search Name: Abdiesel Place: Araguari, Minas Gerais, Brazil Zip: 38445-133 Sector: Services Product: Brazil based biodiesel producer. The company also...

  14. Hidrelectrica Cachoeirao S A | Open Energy Information

    Open Energy Info (EERE)

    Cachoeirao S.A. Place: Minas Gerais, Brazil Sector: Hydro Product: Brazil-based small hydro project developer. References: Hidrelectrica Cachoeirao S.A.1 This article...

  15. Long-term assessment of the oil spill at Bahia Las Minas, Panama. Interim report. Volume 1: Executive summary

    SciTech Connect (OSTI)

    Keller, B.D.; Jackson, J.B.C.

    1991-10-01

    On April 27, 1986, at least 8 million liters of medium-weight crude oil spilled from a ruptured storage tank into the Bahia Las Minas on the Caribbean Coast of Panama. Coral reefs, seagrass communities, and mangroves were affected. The area of the spill was also the location of the Smithsonian Tropical Research Institute's Galeta Laboratory where resident and visiting scientists have been studying the ecology of the Bahia Las Minas and the adjacent areas for over 15 years. Because this was a unique opportunity to assess the immediate biological effects following a major spill in the Caribbean region and to monitor the subsequent recovery, the U.S. Department of the Interior Minerals Management Service supported a 5-year environmental study. The objectives of the study are to identify any long-term changes in the marine environment that may have resulted from the spill and to understand the ecological processes causing such changes. This is the first report from the study and addresses the effects observed during the first two years of the effort.

  16. Long-term assessment of the oil spill at Bahia Las Minas, Panama. Interim report. Volume 2: Technical report

    SciTech Connect (OSTI)

    Keller, B.D.; Jackson, J.B.C.

    1991-10-01

    On April 27, 1986, at least 8 million liters of medium-weight crude oil spilled from a ruptured storage tank into the Bahia Las Minas on the Caribbean Coast of Panama. Coral reefs, seagrass communities, and mangroves were affected. The area of the spill was also the location of the Smithsonian Tropical Research Institute's Galeta Laboratory where resident and visiting scientists have been studying the ecology of the Bahia Las Minas and the adjacent areas for over 15 years. Because this was a unique opportunity to assess the immediate biological effects following a major spill in the Caribbean region and to monitor the subsequent recovery, the U.S. Department of the Interior Minerals Management Service supported a 5-year environmental study. The objectives of the study are to identify any long-term changes in the marine environment that may have resulted from the spill and to understand the ecological processes causing such changes. This is the first report from the study and addresses the effects observed during the first two years of the effort.

  17. Cristina Energia | Open Energy Information

    Open Energy Info (EERE)

    Cristina Energia Jump to: navigation, search Name: Cristina Energia Place: Brazil Sector: Hydro Product: Brazil-based SPV set up to build a 3.5MW small hydro in Minas Gerais....

  18. Hidrelectrica Pipoca S A | Open Energy Information

    Open Energy Info (EERE)

    Hidrelectrica Pipoca S.A. Place: Minas Gerais, Brazil Sector: Hydro Product: Brazil-based small hydro project developer. References: Hidrelectrica Pipoca S.A.1 This article is a...

  19. "FERC423",2005,1,195,"Alabama Power Co",3,"Barry","AL","C",,"Coal","BIT",45,"IM","SU","County Unknown",999,"MINA PRIBBENOW",358990,22.722,0.6,6.1,209.8

    U.S. Energy Information Administration (EIA) Indexed Site

    5,1,195,"Alabama Power Co",3,"Barry","AL","C",,"Coal","BIT",45,"IM","SU","County Unknown",999,"MINA PRIBBENOW",358990,22.722,0.6,6.1,209.8 "FERC423",2005,1,195,"Alabama Power Co",3,"Barry","AL","C",,"Coal","BIT",45,"IM","SU","County Unknown",999,"MINA PRIBBENOW",45260,22.926,0.59,5.7,196.8

  20. "FERC423",2006,1,195,"Alabama Power Co",3,"Barry","AL","C",,"Coal","BIT",45,"IM","SU","County Unknown",999,"MINA PRIBBENOW",273020,22.846,0.62,6.4,192.4

    U.S. Energy Information Administration (EIA) Indexed Site

    6,1,195,"Alabama Power Co",3,"Barry","AL","C",,"Coal","BIT",45,"IM","SU","County Unknown",999,"MINA PRIBBENOW",273020,22.846,0.62,6.4,192.4 "FERC423",2006,1,195,"Alabama Power Co",3,"Barry","AL","I",,"Gas","NG",,,,,,"BAY GAS PIPELINE",597198,1.053,0,0,1185.7 "FERC423",2006,1,195,"Alabama Power

  1. "FERC423",2007,1,195,"Alabama Power Co",3,"Barry","AL","C","application/vnd.ms-excel","Coal","BIT",45,"IM","SU","County Unknown",999,"MINA PRIBBENOW",289050,22.732,0.5,5.2,217.3

    U.S. Energy Information Administration (EIA) Indexed Site

    7,1,195,"Alabama Power Co",3,"Barry","AL","C","application/vnd.ms-excel","Coal","BIT",45,"IM","SU","County Unknown",999,"MINA PRIBBENOW",289050,22.732,0.5,5.2,217.3 "FERC423",2007,1,195,"Alabama Power Co",3,"Barry","AL","C","application/vnd.ms-excel","Coal","BIT",45,"IM","SU","County

  2. Mina J. Bissell, 1996 | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    For her seminal and pioneering contributions to our understanding of the central role of extra-cellular matrix and micro-environment in differentiation, programmed cell death, and ...

  3. MHK Projects/Minas Basin Bay of Fundy Commercial Scale Demonstration...

    Open Energy Info (EERE)

    1 Main Overseeing Organization UEK Corporation Project Technology *MHK TechnologiesUnderwater Electric Kite Turbines Project Timeline and Milestones *712010 Scale bearing...

  4. Women @ Energy: Xin Sun | Department of Energy

    Energy Savers [EERE]

    Mina Bissell Women @ Energy: Mina Bissell March 13, 2013 - 4:49pm Addthis Dr. Mina Bissell has been recognized for her lifetime contributions to the fields of breast cancer research, the enhanced role of extracellular matrix (ECM) and the nucleus environment to gene expression in normal and malignant tissues. Dr. Mina Bissell has been recognized for her lifetime contributions to the fields of breast cancer research, the enhanced role of extracellular matrix (ECM) and the nucleus environment to

  5. Weekly Petroleum Status Report

    U.S. Energy Information Administration (EIA) Indexed Site

    ... - - - - - - - - - - - - - - 12.59 Indonesia 1 Minas 34 ......November 2007. Effective January 2009, Indonesia withdrew from OPEC. Prices have been ...

  6. Energisa Solu es | Open Energy Information

    Open Energy Info (EERE)

    Gerais, Brazil Sector: Hydro Product: Brazilian based small hydro project developer and O&M service provider. References: Energisa Solues1 This article is a stub. You...

  7. La Sabina SA | Open Energy Information

    Open Energy Info (EERE)

    Name: La Sabina SA Place: Estoril, Portugal Zip: 2765-495 Sector: Solar Product: Mining company branching out into solar development. Redeveloping the Mina Sao Domingos area....

  8. Soyminas Biodiesel | Open Energy Information

    Open Energy Info (EERE)

    Soyminas Biodiesel Jump to: navigation, search Name: Soyminas Biodiesel Place: DIST. INDUSTRIAL, Brazil Zip: 37980-000 Product: Brazilian biodiesel producer located in Minas...

  9. International News | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and Security; Mina Golshan, Office for Nuclear Regulation; Tony Handley, Magnox Ltd.; Anna Clark, Nuclear Decommissioning Authority; and Laurie Judd, Longenecker & Associates. ...

  10. Gateway:América Latina/Centros Latinoamericanos | Open Energy...

    Open Energy Info (EERE)

    do Biodiesel- Privado BColombia.jpg Colombia Ministerio de Minas y Energas- Pblico Red Energas Alternativas- Privado BCuba.jpg Cuba Centro de Gestin de la Informacin y...

  11. Consorcio Operacional Energ Anjo | Open Energy Information

    Open Energy Info (EERE)

    Gerais, Brazil Zip: 30220-030 Product: Belo Horizonte-based firm to develop a waste-to-energy portfolio. References: Consorcio Operacional Energ-Anjo1 This article is a...

  12. Category:Marine and Hydrokinetic Technology Projects | Open Energy...

    Open Energy Info (EERE)

    MHK ProjectsMicroturbine River In Stream MHK ProjectsMiette River MHK ProjectsMiller Bend Project MHK ProjectsMilliken Bend Project MHK ProjectsMinas Basin Bay of Fundy...

  13. Unexpected Stable Two-dimensional ...

    Office of Scientific and Technical Information (OSTI)

    Unexpected Stable Two-dimensional Silicon Phosphides with Different Stoichiometries Bing Huang1, Houlong Zhuang1, Mina Yoon1, Su-Huai Wei2, and Bobby G. Sumpter1 1 Center for ...

  14. UK Delegation Focuses on EM's Reactor 'Cocooning' Expertise During

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Hanford Site Tour | Department of Energy UK Delegation Focuses on EM's Reactor 'Cocooning' Expertise During Hanford Site Tour UK Delegation Focuses on EM's Reactor 'Cocooning' Expertise During Hanford Site Tour December 29, 2015 - 12:35pm Addthis The UK delegation gathers at the front of the H Reactor core. Left to right: Amanda Anderson, DOE Office of the Chief of Nuclear Safety; Paul Lonsdale, Magnox Ltd.; Steve Kirchhoff, DOE Office of Environment, Health, Safety and Security; Mina

  15. Successful operation of a large LPG plant. [Kuwait

    SciTech Connect (OSTI)

    Shtayieh, S.; Durr, C.A.; McMillan, J.C.; Collins, C.

    1982-03-01

    The LPG plant located at Mina-Al Ahmadi, Kuwait, is the heart of Kuwait Oil Co.'s massive Gas Project to use the associated gas from Kuwait's oil production. Operation of this three-train plant has been very successful. A description is given of the three process trains consisting of four basic units: extraction, fractionation, product treating, and refrigeration. Initial problems relating to extraction, fractionation, product treating and, refrigeration are discussed. 1 ref.

  16. EWA Contact List

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Company/Product Description Contract Number Contract Holders (contact directly) Small Business Product POCs DOE POC Adobe Adobe's Government Cumulative Licenses Program (CLP) and Enterprise Agreement (EA2) Program. Most Adobe desktop products and services DE-IM0000595 (GSA) Emergent, LLC: Blake Weiss ph: 571-419-6423 bweiss@emergent360.com YES Adobe: Mina Pham ph: 571-765-5485 minpham@adobe.com Carrie Whalen 571.765.5371 (tel) whalen@adobe.com Rob Gettings robert.gettings@hq.doe.gov 301-903-0829

  17. Fermilab Today

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    13, 2015 spacer Subscribe | Contact Us | Archive | Classifieds | Guidelines | Help Search GO spacer Calendar Have a safe day! Friday, March 13 3:30 p.m. Director's Coffee Break - WH2XO THERE WILL BE NO JOINT EXPERIMENTAL-THEORETICAL PHYSICS SEMINAR THIS WEEK 8 p.m. Fermilab Lecture Series - Auditorium Speaker: Mina Bissell, Berkeley National Laboratory Title: New Understandings of Cancer Tickets: $7 Monday, March 16 3:30 p.m. Director's Coffee Break - WH2XO 4 p.m. All Experimenters' Meeting -

  18. Health Detectives: Uncovering the Mysteries of Disease (LBNL Science at the Theater)

    ScienceCinema (OSTI)

    Bissell, Mina; Canaria, Christie; Celnicker, Susan; Karpen, Gary

    2014-05-06

    In this April 23, 2012 Science at the Theater event, Berkeley Lab scientists discuss how they uncover the mysteries of disease in unlikely places. Speakers and topics include: World-renowned cancer researcher Mina Bissell's pioneering research on the role of the cellular microenvironment in breast cancer has changed the conversation about the disease. How does DNA instability cause disease? To find out, Christie Canaria images neural networks to study disorders such as Huntington's disease. Fruit flies can tell us a lot about ourselves. Susan Celniker explores the fruit fly genome to learn how our genome works. DNA is not destiny. Gary Karpen explores how environmental factors shape genome function and disease through epigenetics.

  19. War curbs oil exports by Iran and Iraq

    SciTech Connect (OSTI)

    Not Available

    1980-09-29

    A discussion of the effects of the war between Iran and Iraq on oil exports from the area covers damage (extent unknown) to the Abadan, Iran, and Basra, Iraq, oil refineries, to the Iraqi petrochemical complex under construction at Basra, to oil export terminals at Kharg Island and Mina-al-Bakr, and to other oil facilities; war-caused reductions in oil production, refining, shipping, and export, estimated at 2.05-3.35 million bbl/day; the possible effects of the war on OPEC's decisions concerning oil production and pricing; the significance of the Strait of Hormuz for the export of oil by several countries in addition to the belligerents; the U.S. and non-Communist oil stocks which might enable the world to avoid an oil shortage if the war is ended in the near future; and the long-term effects of the war on Iran's and Iraq's oil industries.

  20. "FERC423",2003,1,195,"Alabama Power Co",3,"Barry","AL","C",,"Coal","BIT",13,"AL","U","Jefferson",73,"SHOAL CREEK MINE",85080,24.098,0.8,13.2,183.1

    U.S. Energy Information Administration (EIA) Indexed Site

    3,1,195,"Alabama Power Co",3,"Barry","AL","C",,"Coal","BIT",13,"AL","U","Jefferson",73,"SHOAL CREEK MINE",85080,24.098,0.8,13.2,183.1 "FERC423",2003,1,195,"Alabama Power Co",3,"Barry","AL","C",,"Coal","BIT",45,"IM","SU","County Unknown",999,"MINA PRIBBEMOW",278810,23.498,0.56,4.3,141.7

  1. Genes and the Microenvironment: Two Faces of Breast Cancer (LBNL Science at the Theater)

    ScienceCinema (OSTI)

    Gray, Joe; Love, Susan M.; Bissell, Min; Barcellos-Hoff, Mary Helen

    2011-10-04

    In this April 21, 2008 Berkeley Lab event, a dynamic panel of Berkeley Lab scientists highlight breast cancer research advances related to susceptibility, early detection, prevention, and therapy - a biological systems approach to tackling the disease from the molecular and cellular levels, to tissues and organs, and ultimately the whole individual. Joe Gray, Berkeley Lab Life Sciences Division Director, explores how chromosomal abnormalities contribute to cancer and respond to gene-targeted therapies. Mina Bissell, former Life Sciences Division Director, approaches the challenge of breast cancer from the breast's three dimensional tissue microenvironment and how the intracellular ''conversation'' triggers malignancies. Mary Helen Barcellos-Hoff, Deputy Director, Life Sciences Division, identifies what exposure to ionizing radiation can tell us about how normal tissues suppress carcinogenesis. The panel is moderated by Susan M. Love, breast cancer research pioneer, author, President and Medical Director of the Dr. Susan Love Research Foundation.

  2. A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides

    SciTech Connect (OSTI)

    Wilhelm, Christina M.; Snider, Thomas H.; Babin, Michael C.; Jett, David A.

    2014-12-15

    The currently fielded pre-hospital therapeutic regimen for the treatment of organophosphorus (OP) poisoning in the United States (U.S.) is the administration of atropine in combination with an oxime antidote (2-PAM Cl) to reactivate inhibited acetylcholinesterase (AChE). Depending on clinical symptoms, an anticonvulsant, e.g., diazepam, may also be administered. Unfortunately, 2-PAM Cl does not offer sufficient protection across the range of OP threat agents, and there is some question as to whether it is the most effective oxime compound available. The objective of the present study is to identify an oxime antidote, under standardized and comparable conditions, that offers protection at the FDA approved human equivalent dose (HED) of 2-PAM Cl against tabun (GA), sarin (GB), soman (GD), cyclosarin (GF), and VX, and the pesticides paraoxon, chlorpyrifos oxon, and phorate oxon. Male Hartley guinea pigs were subcutaneously challenged with a lethal level of OP and treated at approximately 1 min post challenge with atropine followed by equimolar oxime therapy (2-PAM Cl, HI-6 DMS, obidoxime Cl{sub 2}, TMB-4, MMB4-DMS, HLö-7 DMS, MINA, and RS194B) or therapeutic-index (TI) level therapy (HI-6 DMS, MMB4-DMS, MINA, and RS194B). Clinical signs of toxicity were observed for 24 h post challenge and blood cholinesterase [AChE and butyrylcholinesterase (BChE)] activity was analyzed utilizing a modified Ellman's method. When the oxime is standardized against the HED of 2-PAM Cl for guinea pigs, the evidence from clinical observations, lethality, quality of life (QOL) scores, and cholinesterase reactivation rates across all OPs indicated that MMB4 DMS and HLö-7 DMS were the two most consistently efficacious oximes. - Highlights: • First comprehensive evaluation of leading AChE oxime reactivators • All oximes are compared against current U.S. therapy 2-PAM Cl. • Relative therapeutic oxime efficacies against OP CWNA and pesticides • Contribution to more effective antidotes for civilian and military populations.

  3. Deployment Effects of Marin Renewable Energy Technologies

    SciTech Connect (OSTI)

    Brian Polagye; Mirko Previsic

    2010-06-17

    Given proper care in siting, design, deployment, operation and maintenance, marine and hydrokinetic technologies could become one of the more environmentally benign sources of electricity generation. In order to accelerate the adoption of these emerging hydrokinetic and marine energy technologies, navigational and environmental concerns must be identified and addressed. All developing hydrokinetic projects involve a wide variety of stakeholders. One of the key issues that site developers face as they engage with this range of stakeholders is that many of the possible conflicts (e.g., shipping and fishing) and environmental issues are not well-understood, due to a lack of technical certainty. In September 2008, re vision consulting, LLC was selected by the Department of Energy (DoE) to apply a scenario-based approach to the emerging wave and tidal technology sectors in order to evaluate the impact of these technologies on the marine environment and potentially conflicting uses. The project’s scope of work includes the establishment of baseline scenarios for wave and tidal power conversion at potential future deployment sites. The scenarios will capture variations in technical approaches and deployment scales to properly identify and characterize environmental impacts and navigational effects. The goal of the project is to provide all stakeholders with an improved understanding of the potential effects of these emerging technologies and focus all stakeholders onto the critical issues that need to be addressed. This groundwork will also help in streamlining siting and associated permitting processes, which are considered key hurdles for the industry’s development in the U.S. today. Re vision is coordinating its efforts with two other project teams funded by DoE which are focused on regulatory and navigational issues. The results of this study are structured into three reports: 1. Wave power scenario description 2. Tidal power scenario description 3. Framework for Identifying Key Environmental Concerns This is the second report in the sequence and describes the results of conceptual feasibility studies of tidal power plants deployed in Tacoma Narrows, Washington. The Narrows contain many of the same competing stakeholder interactions identified at other tidal power sites and serves as a representative case study. Tidal power remains at an early stage of development. As such, a wide range of different technologies are being pursued by different manufacturers. In order to properly characterize impacts, it is useful to characterize the range of technologies that could be deployed at the site of interest. An industry survey informs the process of selecting representative tidal power devices. The selection criteria is that such devices are at an advanced stage of development to reduce technical uncertainties and that enough data are available from the manufacturers to inform the conceptual design process of this study. Further, an attempt is made to cover the range of different technologies under development to capture variations in potential environmental effects. A number of other developers are also at an advanced stage of development including Verdant Power, which has demonstrated an array of turbines in the East River of New York, Clean Current, which has demonstrated a device off Race Rocks, BC, and OpenHydro, which has demonstrated a device at the European Marine Energy Test Center and is on the verge of deploying a larger device in the Bay of Fundy. MCT demonstrated their device both at Devon (UK) and Strangford Narrows (Northern Ireland). Furthermore OpenHydro, CleanCurrent, and MCT are the three devices being installed at the Minas Passage (Canada). Environmental effects will largely scale with the size of tidal power development. In many cases, the effects of a single device may not be measurable, while larger scale device arrays may have cumulative impacts that differ significantly from smaller scale deployments. In order to characterize these effects, scenarios are established at three deployment scales which nominally represent (1) a small pilot deployment, (2) an early, small commercial deployment, and (3) a large commercial scale plant. For the three technologies and scales at the selected site, this results in a total of nine deployment scenarios outlined in the report.