Sample records for migration pathway timing

  1. Tungsten Cluster Migration on Nanoparticles: Minimum Energy Pathway...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pathway and Migration Mechanism. Tungsten Cluster Migration on Nanoparticles: Minimum Energy Pathway and Migration Mechanism. Abstract: Transition state searches have been...

  2. ERK-dependent and -independent pathways trigger human neural progenitor cell migration

    SciTech Connect (OSTI)

    Moors, Michaela [Institut fuer Umweltmedizinische Forschung gGmbH at the Heinrich Heine-University, Group of Toxicology, Auf'm Hennekamp 50, 40225 Duesseldorf (Germany)]. E-mail: moors@uni-duesseldorf.de; Cline, Jason E. [Institut fuer Umweltmedizinische Forschung gGmbH at the Heinrich Heine-University, Group of Toxicology, Auf'm Hennekamp 50, 40225 Duesseldorf (Germany)]. E-mail: jason.cline@uni-duesseldorf.de; Abel, Josef [Institut fuer Umweltmedizinische Forschung gGmbH at the Heinrich Heine-University, Group of Toxicology, Auf'm Hennekamp 50, 40225 Duesseldorf (Germany)]. E-mail: josef.abel@uni-duesseldorf.de; Fritsche, Ellen [Institut fuer Umweltmedizinische Forschung gGmbH at the Heinrich Heine-University, Group of Toxicology, Auf'm Hennekamp 50, 40225 Duesseldorf (Germany)]. E-mail: ellen.fritsche@uni-duesseldorf.de

    2007-05-15T23:59:59.000Z

    Besides differentiation and apoptosis, cell migration is a basic process in brain development in which neural cells migrate several centimeters within the developing brain before reaching their proper positions and forming the right connections. For identifying signaling events that control neural migration and are therefore potential targets of chemicals to disturb normal brain development, we developed a human neurosphere-based migration assay based on normal human neural progenitor (NHNP) cells, in which the distance is measured that cells wander over time. Applying this assay, we investigated the role of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) in the regulation of NHNP cell migration. Exposure to model substances like ethanol or phorbol 12-myristate 13-acetate (PMA) revealed a correlation between ERK1/2 activation and cell migration. The participation of phospho-(P-) ERK1/2 was confirmed by exposure of the cells to the MEK inhibitor PD98059, which directly prohibits ERK1/2 phosphorylation and inhibited cell migration. We identified protein kinase C (PKC) and epidermal growth factor receptor (EGFR) as upstream signaling kinases governing ERK1/2 activation, thereby controlling NHNP cell migration. Additionally, treatments with src kinase inhibitors led to a diminished cell migration without affecting ERK1/2 phosphorylation. Based on these results, we postulate that migration of NHNP cells is controlled via ERK1/2-dependent and -independent pathways.

  3. Seismic Velocity Estimation from Time Migration Maria Kourkina Cameron

    E-Print Network [OSTI]

    Cameron, Maria Kourkina

    Seismic Velocity Estimation from Time Migration by Maria Kourkina Cameron Diplom (Moscow Institute Dung-Hai Lee Spring 2007 #12;Seismic Velocity Estimation from Time Migration Copyright c 2007 by Maria Kourkina Cameron #12;Abstract Seismic Velocity Estimation from Time Migration by Maria Kourkina Cameron

  4. Tungsten Cluster Migration on Nanoparticles: Minimum Energy Pathway and Migration Mechanism

    SciTech Connect (OSTI)

    Chen, Dong; Hu, Wangyu; Gao, Fei; Deng, Huiqiu; Sun, Lixian

    2011-03-02T23:59:59.000Z

    Transition state searches have been employed to investigate the migration mechanisms of W clusters on W nanoparticles, and to determine the corresponding migration energies for the possible migration paths of these clusters. The tungsten clusters containing up to four adatoms are found to prefer 2D-compact structures with relatively low binding energies. The effect of interface and vertex regions on the migration behavior of the clusters is significantly strong, as compared to that of nanoparticle size. The migration mechanisms are quite different when the clusters are located at the center of the nanoparticle and near the interface or vertex areas. Near the interfaces and vertex areas, the substrate atoms tend to participate in the migration processes of the clusters, and can join the adatoms to form a larger cluster or lead to the dissociation of a cluster via the exchange mechanism, which results in the adatom crossing the facets. The lowest energy paths are used to be determined the energy barriers for W cluster migrations (from 1- to 4-atoms) on the facets, edges and vertex regions. The calculated energy barriers for the trimers suggest that the concerted migration is more probable than the successive jumping of a single adatom in the clusters. In addition, it of interest to note that the dimer shearing is a dominant migration mechanism for the tetramer, but needs to overcome a relatively higher migration energy than other clusters.

  5. Hydrocarbon accumulation on rifted Continental Margin - examples of oil migration pathways, west African salt basins

    SciTech Connect (OSTI)

    Blackwelder, B.W.

    1989-03-01T23:59:59.000Z

    Examination of the oil fields in the Gabon, Lower Congo, and Cuanza basins allows modeling of oil migration and a more accurate ranking of prospects using geologic risk factors. Oil accumulations in these basins are in strata deposited during Cretaceous rift and drift phases, thus providing a diversity of geologic settings to examine. Oil accumulations in rift deposits are located on large faulted anticlines or in truncated units atop horst features. Many of these oil fields were sourced from adjacent organic shales along short direct migration paths. In Areas where source rock is more remote to fields or to prospective structures, faulting and continuity of reservoir rock are important to the migration of hydrocarbons. Because Aptian salts separate rift-related deposits from those of the drift stage, salt evacuation and faulting of the salt residuum are necessary for oil migration from the pre-salt sequences into the post-salt section. Oil migration within post-salt strata is complicated by the presence of salt walls and faulted carbonate platforms. Hydrocarbon shows in wells drilled throughout this area provide critical data for evaluating hydrocarbon migration pathways. Such evaluation in combination with modeling and mapping of the organic-rich units, maturation, reservoir facies, structural configurations, and seals in existing fields allows assessment of different plays. Based on this information, new play types and prospective structures can be ranked with respect to geologic risk.

  6. Pathways of migration of oil and gas in south Mississippi salt basin

    SciTech Connect (OSTI)

    Evans, R.

    1987-09-01T23:59:59.000Z

    The South Mississippi salt basin is one of three interior basins characterized by structures formed by movement of the Late Jurassic Louann Salt. An analysis of pathways of migration within the basin has revealed that it is possible to explain why hydrocarbons have accumulated in some structures, yet are absent from others that would appear to be favorable. Seventy-four of the more than 840 fields within the basin, including the largest known accumulations, have hydrocarbons in stacked reservoirs belonging in more than one formation. These stacked reservoirs result from vertical migration facilitated by faulting. In more than 750 fields, hydrocarbons are confined to a single formation in traps associated with four distinct trends of production that decrease in age systematically from the margin of the basin into the interior. The hydrocarbons in these trends have accumulated by intrastratal migration (without the agency of faulting) from a nearby source in the same unit as the reservoir. On the northwest side of the basin, migration between units brought into contact along unconformities has resulted in 10 fields. Vertical migration brought about by faulting around shallow salt diapirs has allowed hydrocarbons to escape, so that only 5 of 56 such structures have produced oil or gas. These conclusions, derived from geologic deductions, are supported by preliminary geochemical data; more extensive and detailed geochemical analyses of oils from the various sources are under way.

  7. Mechano-growth factor induces migration of rat mesenchymal stem cells by altering its mechanical properties and activating ERK pathway

    SciTech Connect (OSTI)

    Wu, Jiamin; Wu, Kewen; Lin, Feng; Luo, Qing; Yang, Li; Shi, Yisong [Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044 (China)] [Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044 (China); Song, Guanbin, E-mail: song@cqu.edu.cn [Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044 (China)] [Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044 (China); Sung, Kuo-Li Paul [Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044 (China) [Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044 (China); Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093-0412 (United States)

    2013-11-08T23:59:59.000Z

    Highlights: •MGF induced the migration of rat MSC in a concentration-dependent manner. •MGF enhanced the mechanical properties of rMSC in inducing its migration. •MGF activated the ERK 1/2 signaling pathway of rMSC in inducing its migration. •rMSC mechanics may synergy with ERK 1/2 pathway in MGF-induced rMSC migration. -- Abstract: Mechano-growth factor (MGF) generated by cells in response to mechanical stimulation has been identified as a mechano effector molecule, playing a key role in regulating mesenchymal stem cell (MSC) function, including proliferation and migration. However, the mechanism(s) underlying how MGF-induced MSC migration occurs is still unclear. In the present study, MGF motivated migration of rat MSCs (rMSCs) in a concentration-dependent manner and optimal concentration of MGF at 50 ng/mL (defined as MGF treatment in this paper) was demonstrated. Notably, enhancement of mechanical properties that is pertinent to cell migration, such as cell traction force and cell stiffness were found to respond to MGF treatment. Furthermore, MGF increased phosphorylation of extracellular signal-regulated kinase (ERK), ERK inhibitor (i.e., PD98059) suppressed ERK phosphorylation, and abolished MGF-induced rMSC migration were found, demonstrating that ERK is involved molecule for MGF-induced rMSC migration. These in vitro evidences of MGF-induced rMSC migration and its direct link to altering rMSC mechanics and activating the ERK pathway, uncover the underlying biomechanical and biological mechanisms of MGF-induced rMSC migration, which may help find MGF-based application of MSC in clinical therapeutics.

  8. Hedgehog pathway regulators influence cervical cancer cell proliferation, survival and migration

    SciTech Connect (OSTI)

    Samarzija, Ivana [Ecole Polytechnique Federale Lausanne (EPFL), Department of Life Sciences, Swiss Institute for Experimental Cancer Research (ISREC), 1015 Lausanne (Switzerland)] [Ecole Polytechnique Federale Lausanne (EPFL), Department of Life Sciences, Swiss Institute for Experimental Cancer Research (ISREC), 1015 Lausanne (Switzerland); Beard, Peter, E-mail: peter.beard@epfl.ch [Ecole Polytechnique Federale Lausanne (EPFL), Department of Life Sciences, Swiss Institute for Experimental Cancer Research (ISREC), 1015 Lausanne (Switzerland)] [Ecole Polytechnique Federale Lausanne (EPFL), Department of Life Sciences, Swiss Institute for Experimental Cancer Research (ISREC), 1015 Lausanne (Switzerland)

    2012-08-17T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Unknown cellular mutations complement papillomavirus-induced carcinogenesis. Black-Right-Pointing-Pointer Hedgehog pathway components are expressed by cervical cancer cells. Black-Right-Pointing-Pointer Hedgehog pathway activators and inhibitors regulate cervical cancer cell biology. Black-Right-Pointing-Pointer Cell immortalization by papillomavirus and activation of Hedgehog are independent. -- Abstract: Human papillomavirus (HPV) infection is considered to be a primary hit that causes cervical cancer. However, infection with this agent, although needed, is not sufficient for a cancer to develop. Additional cellular changes are required to complement the action of HPV, but the precise nature of these changes is not clear. Here, we studied the function of the Hedgehog (Hh) signaling pathway in cervical cancer. The Hh pathway can have a role in a number of cancers, including those of liver, lung and digestive tract. We found that components of the Hh pathway are expressed in several cervical cancer cell lines, indicating that there could exists an autocrine Hh signaling loop in these cells. Inhibition of Hh signaling reduces proliferation and survival of the cervical cancer cells and induces their apoptosis as seen by the up-regulation of the pro-apoptotic protein cleaved caspase 3. Our results indicate that Hh signaling is not induced directly by HPV-encoded proteins but rather that Hh-activating mutations are selected in cells initially immortalized by HPV. Sonic Hedgehog (Shh) ligand induces proliferation and promotes migration of the cervical cancer cells studied. Together, these results indicate pro-survival and protective roles of an activated Hh signaling pathway in cervical cancer-derived cells, and suggest that inhibition of this pathway may be a therapeutic option in fighting cervical cancer.

  9. Reverse Time Migration for Extended Obstacles: Acoustic Waves

    E-Print Network [OSTI]

    Junqing Chen; Zhiming Chen; Guanghui Huang

    2014-06-10T23:59:59.000Z

    We consider the resolution of the single frequency reverse time migration (RTM) method for extended targets without the assumption of the validation of geometric optics approximation. The resolution analysis, which applies in both penetrable and non-penetrable obstacles with sound soft or impedance boundary condition on the boundary of the obstacle, implies that the imaginary part of the cross-correlation imaging functional is always positive and thus may have better stability properties. Numerical experiments are included to illustrate the powerful imaging quality and to confirm our resolution results.

  10. Method for identifying subsurface fluid migration and drainage pathways in and among oil and gas reservoirs using 3-D and 4-D seismic imaging

    DOE Patents [OSTI]

    Anderson, R.N.; Boulanger, A.; Bagdonas, E.P.; Xu, L.; He, W.

    1996-12-17T23:59:59.000Z

    The invention utilizes 3-D and 4-D seismic surveys as a means of deriving information useful in petroleum exploration and reservoir management. The methods use both single seismic surveys (3-D) and multiple seismic surveys separated in time (4-D) of a region of interest to determine large scale migration pathways within sedimentary basins, and fine scale drainage structure and oil-water-gas regions within individual petroleum producing reservoirs. Such structure is identified using pattern recognition tools which define the regions of interest. The 4-D seismic data sets may be used for data completion for large scale structure where time intervals between surveys do not allow for dynamic evolution. The 4-D seismic data sets also may be used to find variations over time of small scale structure within individual reservoirs which may be used to identify petroleum drainage pathways, oil-water-gas regions and, hence, attractive drilling targets. After spatial orientation, and amplitude and frequency matching of the multiple seismic data sets, High Amplitude Event (HAE) regions consistent with the presence of petroleum are identified using seismic attribute analysis. High Amplitude Regions are grown and interconnected to establish plumbing networks on the large scale and reservoir structure on the small scale. Small scale variations over time between seismic surveys within individual reservoirs are identified and used to identify drainage patterns and bypassed petroleum to be recovered. The location of such drainage patterns and bypassed petroleum may be used to site wells. 22 figs.

  11. Method for identifying subsurface fluid migration and drainage pathways in and among oil and gas reservoirs using 3-D and 4-D seismic imaging

    DOE Patents [OSTI]

    Anderson, Roger N. (New York, NY); Boulanger, Albert (New York, NY); Bagdonas, Edward P. (Brookline, MA); Xu, Liqing (New Milford, NJ); He, Wei (New Milford, NJ)

    1996-01-01T23:59:59.000Z

    The invention utilizes 3-D and 4-D seismic surveys as a means of deriving information useful in petroleum exploration and reservoir management. The methods use both single seismic surveys (3-D) and multiple seismic surveys separated in time (4-D) of a region of interest to determine large scale migration pathways within sedimentary basins, and fine scale drainage structure and oil-water-gas regions within individual petroleum producing reservoirs. Such structure is identified using pattern recognition tools which define the regions of interest. The 4-D seismic data sets may be used for data completion for large scale structure where time intervals between surveys do not allow for dynamic evolution. The 4-D seismic data sets also may be used to find variations over time of small scale structure within individual reservoirs which may be used to identify petroleum drainage pathways, oil-water-gas regions and, hence, attractive drilling targets. After spatial orientation, and amplitude and frequency matching of the multiple seismic data sets, High Amplitude Event (HAE) regions consistent with the presence of petroleum are identified using seismic attribute analysis. High Amplitude Regions are grown and interconnected to establish plumbing networks on the large scale and reservoir structure on the small scale. Small scale variations over time between seismic surveys within individual reservoirs are identified and used to identify drainage patterns and bypassed petroleum to be recovered. The location of such drainage patterns and bypassed petroleum may be used to site wells.

  12. Seismic velocity estimation and time to depth conversion of time-migrated images Maria Cameron, University of California at Berkeley, Sergey Fomel, University of Texas at Austin, and

    E-Print Network [OSTI]

    Sethian, James A.

    Seismic velocity estimation and time to depth conversion of time-migrated images Maria Cameron migrated seismic images and show that the Dix velocities estimated from time migration velocities are the true seismic velocities divided by the ge- ometrical spreading of image rays. We pose an inverse

  13. Ligand Migration and Cavities within Scapharca Dimeric HbI: Studies by Time-Resolved Crystallo- graphy, Xe Binding, and Computational Analysis

    SciTech Connect (OSTI)

    Knapp, James E.; Pahl, Reinhard; Cohen, Jordi; Nichols, Jeffry C.; Schulten, Klaus; Gibson, Quentin H.; Š rajer, Vukica; Royer, Jr., William E.; (UMASS MED); (UIUC); (UC_

    2009-12-01T23:59:59.000Z

    As in many other hemoglobins, no direct route for migration of ligands between solvent and active site is evident from crystal structures of Scapharca inaequivalvis dimeric HbI. Xenon (Xe) and organic halide binding experiments, along with computational analysis presented here, reveal protein cavities as potential ligand migration routes. Time-resolved crystallographic experiments show that photodissociated carbon monoxide (CO) docks within 5 ns at the distal pocket B site and at more remote Xe4 and Xe2 cavities. CO rebinding is not affected by the presence of dichloroethane within the major Xe4 protein cavity, demonstrating that this cavity is not on the major exit pathway. The crystal lattice has a substantial influence on ligand migration, suggesting that significant conformational rearrangements may be required for ligand exit. Taken together, these results are consistent with a distal histidine gate as one important ligand entry and exit route, despite its participation in the dimeric interface.

  14. Fast Seismic Modeling and Reverse Time Migration on a GPU Cluster R. Abdelkhalek1

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Fast Seismic Modeling and Reverse Time Migration on a GPU Cluster R. Abdelkhalek1 , H. Calandra1 equation in an oil exploration industrial context aims at speeding up seismic modeling and Reverse Time application over a sequential code running on general purpose CPU. KEYWORDS: Seismic modeling, Finite

  15. Seismic Velocity Estimation from Time Migration Velocities M. K. Cameron, S. B. Fomel, J. A. Sethian

    E-Print Network [OSTI]

    Sethian, James A.

    Seismic Velocity Estimation from Time Migration Velocities M. K. Cameron, S. B. Fomel, J. A the problem of estimating seismic velocities inside the earth which is necessary for obtaining seismic images in regular Cartesian coordinates. We derive a relation between the true seismic velocities and the routinely

  16. Unraveling the Timing of Fluid Migration and Trap Formation in the Brooks Range Foothills: A Key to Discovering Hydrocarbons

    SciTech Connect (OSTI)

    Catherine L. Hanks

    2008-12-31T23:59:59.000Z

    Naturally occurring fractures can play a key role in the evolution and producibility of a hydrocarbon accumulation. Understanding the evolution of fractures in the Brooks Range/Colville basin system of northern Alaska is critical to developing a better working model of the hydrocarbon potential of the region. This study addressed this problem by collecting detailed and regional data on fracture distribution and character, structural geometry, temperature, the timing of deformation along the Brooks Range rangefront and adjacent parts of the Colville basin, and the in situ stress distribution within the Colville basin. This new and existing data then were used to develop a model of how fractures evolved in northern Alaska, both spatially and temporally. The results of the study indicate that fractures formed episodically throughout the evolution of northern Alaska, due to a variety of mechanisms. Four distinct fracture sets were observed. The earliest fractures formed in deep parts of the Colville basin and in the underlying Ellesmerian sequence rocks as these rocks experienced compression associated with the growing Brooks Range fold-and-thrust belt. The orientation of these deep basin fractures was controlled by the maximum in situ horizontal stress in the basin at the time of their formation, which was perpendicular to the active Brooks Range thrust front. This orientation stayed consistently NS-striking for most of the early history of the Brooks Range and Colville basin, but changed to NW-striking with the development of the northeastern Brooks Range during the early Tertiary. Subsequent incorporation of these rocks into the fold-and-thrust belt resulted in overprinting of these deep basin fractures by fractures caused by thrusting and related folding. The youngest fractures developed as rocks were uplifted and exposed. While this general order of fracturing remains consistent across the Brooks Range and adjacent Colville basin, the absolute age at any one location varies. Fracturing started in the southwest deep in the stratigraphic section during the Late Jurassic and Early Cretaceous, moving northeastward and upsection as the Colville basin filled from the west. Active fracturing is occurring today in the northeastern parts of the Colville basin, north of the northeastern Brooks thrust front. Across northern Alaska, the early deep basin fractures were probably synchronous with hydrocarbon generation. Initially, these early fractures would have been good migration pathways, but would have been destroyed where subsequently overridden by the advancing Brooks Range fold-and-thrust belt. However, at these locations younger fracture sets related to folding and thrusting could have enhanced reservoir permeability and/or served as vertical migration pathways to overlying structural traps.

  17. Late-Pliocene timing of Corinth (Greece) rift-margin fault migration M.R. Leeder a,

    E-Print Network [OSTI]

    Utrecht, Universiteit

    Late-Pliocene timing of Corinth (Greece) rift-margin fault migration M.R. Leeder a, , G.H. Mack b Greece with respect to central Greece (v

  18. A 4D synchrotron X-ray tomography study of the formation of hydrocarbon migration pathways in heated organic-rich shale

    E-Print Network [OSTI]

    Panahi, Hamed; Renard, Francois; Mazzini, Adriano; Scheibert, Julien; Dysthe, Dag Kristian; Jamtveit, Bjorn; Malthe-Sørenssen, Anders; Meakin, Paul

    2014-01-01T23:59:59.000Z

    Recovery of oil from oil shales and the natural primary migration of hydrocarbons are closely related processes that have received renewed interests in recent years because of the ever tightening supply of conventional hydrocarbons and the growing production of hydrocarbons from low permeability tight rocks. Quantitative models for conversion of kerogen into oil and gas and the timing of hydrocarbon generation have been well documented. However, lack of consensus about the kinetics of hydrocarbon formation in source rocks, expulsion timing and how the resulting hydrocarbons escape from or are retained in the source rocks motivates further investigation. In particular, many mechanisms for the transport of hydrocarbons from the source rocks in which they are generated into adjacent rocks with higher permeabilities and smaller capillary entry pressures have been proposed, and a better understanding of this complex process (primary migration) is needed. To characterize these processes it is imperative to use the ...

  19. Unbiased computation of transition times by pathway recombination

    SciTech Connect (OSTI)

    Kuipers, J. [Institute for Theoretical Physics, Utrecht University, Leuvenlaan 4, Utrecht 3584 CE (Netherlands); Barkema, G. T. [Institute for Theoretical Physics, Utrecht University, Leuvenlaan 4, Utrecht 3584 CE (Netherlands); Instituut-Lorentz for Theoretical Physics, Leiden University, Niels Bohrweg 2, Leiden 2333 CA (Netherlands)

    2008-05-07T23:59:59.000Z

    In many systems, the time scales of the microscopic dynamics and macroscopic dynamics of interest are separated by many orders of magnitude. Examples abound, for instance, nucleation, protein folding, and chemical reactions. For these systems, direct simulation of phase space trajectories does not efficiently determine most physical quantities of interest. The past decade has seen the advent of methods circumventing brute force simulation. For most dynamical quantities, these methods all share the drawback of systematical errors. We present a novel method for generating ensembles of phase space trajectories. By sampling small pieces of these trajectories in different phase space domains and piecing them together in a smart way using equilibrium properties, we obtain physical quantities such as transition times. This method does not have any systematical error and is very efficient; the computational effort to calculate the first passage time across a free energy barrier does not increase with the height of the barrier. The strength of the method is shown in the Ising model. Accurate measurements of nucleation times span almost ten orders of magnitude and reveal corrections to classical nucleation theory.

  20. Timing is everything : along the fossil fuel transition pathway.

    SciTech Connect (OSTI)

    Kobos, Peter Holmes; Walker, La Tonya Nicole; Malczynski, Leonard A.

    2013-10-01T23:59:59.000Z

    People save for retirement throughout their career because it is virtually impossible to save all you'll need in retirement the year before you retire. Similarly, without installing incremental amounts of clean fossil, renewable or transformative energy technologies throughout the coming decades, a radical and immediate change will be near impossible the year before a policy goal is set to be in place. Therefore, our research question is,To meet our desired technical and policy goals, what are the factors that affect the rate we must install technology to achieve these goals in the coming decades?' Existing models do not include full regulatory constraints due to their often complex, and inflexible approaches to solve foroptimal' engineering instead ofrobust' and multidisciplinary solutions. This project outlines the theory and then develops an applied software tool to model the laboratory-to-market transition using the traditional technology readiness level (TRL) framework, but develops subsequent and a novel regulatory readiness level (RRL) and market readiness level (MRL). This tool uses the ideally-suited system dynamics framework to incorporate feedbacks and time delays. Future energy-economic-environment models, regardless of their programming platform, may adapt this software model component framework ormodule' to further vet the likelihood of new or innovative technology moving through the laboratory, regulatory and market space. The prototype analytical framework and tool, called the Technology, Regulatory and Market Readiness Level simulation model (TRMsim) illustrates the interaction between technology research, application, policy and market dynamics as they relate to a new or innovative technology moving from the theoretical stage to full market deployment. The initial results that illustrate the model's capabilities indicate for a hypothetical technology, that increasing the key driver behind each of the TRL, RRL and MRL components individually decreases the time required for the technology to progress through each component by 63, 68 and 64%, respectively. Therefore, under the current working assumptions, to decrease the time it may take for a technology to move from the conceptual stage to full scale market adoption one might consider expending additional effort to secure regulatory approval and reducing the uncertainty of the technology's demand in the marketplace.

  1. Defining migration Measuring migration

    E-Print Network [OSTI]

    Huang, Youqin

    Census: 5-year period Tend to underestimate migration. WHY? Registration: Scandinavian countries, China-off Non-monetary costs and benefits Public goods Critique? 0 )1(1 T t t t ij t i t j ij r CUU PV: 3. Family Migration Theory Net family gain Costs and benefits "Tied migrants" (Mincer, 1978

  2. A 4D Synchrotron X-Ray-Tomography Study of the Formation of Hydrocarbon- Migration Pathways in Heated Organic-Rich Shale

    SciTech Connect (OSTI)

    Hamed Panahi; Paul Meakin; Francois Renard; Maya Kobchenko; Julien Scheibert; Adriano Mazzini; Bjorn Jamtveit; Anders Malthe-Sorenssen; Dag Kristian Dysthe

    2013-04-01T23:59:59.000Z

    Recovery of oil from oil shales and the natural primary migration of hydrocarbons are closely related processes that have received renewed interest in recent years because of the ever tightening supply of conventional hydrocarbons and the growing production of hydrocarbons from low-permeability tight rocks. Quantitative models for conversion of kerogen into oil and gas and the timing of hydrocarbon generation have been well documented. However, lack of consensus about the kinetics of hydrocarbon formation in source rocks, expulsion timing, and how the resulting hydrocarbons escape from or are retained in the source rocks motivates further investigation. In particular, many mechanisms have been proposed for the transport of hydrocarbons from the rocks in which they are generated into adjacent rocks with higher permeabilities and smaller capillary entry pressures, and a better understanding of this complex process (primary migration) is needed. To characterize these processes, it is imperative to use the latest technological advances. In this study, it is shown how insights into hydrocarbon migration in source rocks can be obtained by using sequential high-resolution synchrotron X-ray tomography. Three-dimensional images of several immature "shale" samples were constructed at resolutions close to 5 um. This is sufficient to resolve the source-rock structure down to the grain level, but very-fine-grained silt particles, clay particles, and colloids cannot be resolved. Samples used in this investigation came from the R-8 unit in the upper part of the Green River shale, which is organic rich, varved, lacustrine marl formed in Eocene Lake Uinta, USA. One Green River shale sample was heated in situ up to 400 degrees C as X-ray-tomography images were recorded. The other samples were scanned before and after heating at 400 degrees C. During the heating phase, the organic matter was decomposed, and gas was released. Gas expulsion from the low-permeability shales was coupled with formation of microcracks. The main technical difficulty was numerical extraction of microcracks that have apertures in the 5- to 30-um range (with 5 um being the resolution limit) from a large 3D volume of X-ray attenuation data. The main goal of the work presented here is to develop a methodology to process these 3D data and image the cracks. This methodology is based on several levels of spatial filtering and automatic recognition of connected domains. Supportive petrographic and thermogravimetric data were an important complement to this study. An investigation of the strain field using 2D image correlation analyses was also performed. As one application of the 4D (space + time) microtomography and the developed workflow, we show that fluid generation was accompanied by crack formation. Under different conditions, in the subsurface, this might provide paths for primary migration.

  3. Inhibition of fatty acid synthase suppresses U-2 OS cell invasion and migration via downregulating the activity of HER2/PI3K/AKT signaling pathway in vitro

    SciTech Connect (OSTI)

    Wang, Tao Fang; Wang, Heng [Department of Orthopedics, First Affiliated Hospital of Nanchang University, Jiangxi (China)] [Department of Orthopedics, First Affiliated Hospital of Nanchang University, Jiangxi (China); Peng, Ai Fen [Jiangxi University of Traditional Chinese Medicine, Jiangxi (China)] [Jiangxi University of Traditional Chinese Medicine, Jiangxi (China); Luo, Qing Feng [Department of Pathology, Cancer Hospital of Jiangxi Province, Jiangxi (China)] [Department of Pathology, Cancer Hospital of Jiangxi Province, Jiangxi (China); Liu, Zhi Li, E-mail: zgm7977@163.com [Department of Orthopedics, First Affiliated Hospital of Nanchang University, Jiangxi (China); Zhou, Rong Ping [Department of Orthopedics, Second Affiliated Hospital of Nanchang University, Jiangxi (China)] [Department of Orthopedics, Second Affiliated Hospital of Nanchang University, Jiangxi (China); Gao, Song; Zhou, Yang; Chen, Wen Zhao [Department of Orthopedics, First Affiliated Hospital of Nanchang University, Jiangxi (China)] [Department of Orthopedics, First Affiliated Hospital of Nanchang University, Jiangxi (China)

    2013-10-18T23:59:59.000Z

    Highlights: •We investigate the relationship between FASN and HER2 or p-HER2 by IHC in OS tissues. •We construct FASN-specific RNAi plasmid. •Inhibiting FASN down-regulates HER2/PI3K/AKT cell signaling in U-2 OS. •Inhibiting FASN blocks U-2 OS cell invasion and migration. -- Abstract: FASN plays an important role in the malignant phenotype of various tumors. Our previous studies show that inhibition FASN could induce apoptosis and inhibit proliferation in human osteosarcoma (OS) cell in vivo and vitro. The aim in this study was to investigate the effect of inhibition FASN on the activity of HER2/PI3K/AKT axis and invasion and migration of OS cell. The expression of FASN, HER2 and p-HER2(Y1248) proteins was detected by immunohistochemistry in OS tissues from 24 patients with pulmonary metastatic disease, and the relationship between FASN and p-HER2 as well as HER2 was investigated. The results showed that there was a positive correlation between FASN and HER2 as well as p-HER2 protein expression. The U-2 OS cells were transfected with either the FASN specific RNAi plasmid or the negative control RNAi plasmid. FASN mRNA was measured by RT-PCR. Western blot assays was performed to examine the protein expression of FASN, HER2, p-HER2(Y1248), PI3K, Akt and p-Akt (Ser473). Migration and invasion of cells were investigated by wound healing and transwell invasion assays. The results showed that the activity of HER2/PI3K/AKT signaling pathway was suppressed by inhibiting FASN. Meanwhile, the U-2OS cells migration and invasion were also impaired by inhibiting the activity of FASN/HER2/PI3K/AKT. Our results indicated that inhibition of FASN suppresses OS cell invasion and migration via down-regulation of the “HER2/PI3K/AKT” axis in vitro. FASN blocker may be a new therapeutic strategy in OS management.

  4. Information Management Software Services SAP Migrations Service

    E-Print Network [OSTI]

    , customers worldwide have maximized their SAP systems by providing a streamlined migration path to DB2Assessment Prepare SAP migration project plan templates before the project starts to allow extra time to define the order in which your SAP landscape(s) and systems are migrated. Once the migration assessment phase

  5. Planet migration in self-gravitating disks

    E-Print Network [OSTI]

    Meru, Farzana; Baruteau, Clement

    2010-01-01T23:59:59.000Z

    and migration of the planet at the same time so that theG. W. 1978, Moon and Planets, 18, 5 Fukagawa, M. , Hayashi,Planet migration in self-gravitating protoplanetary discs

  6. Geochemical evidence for possible natural migration of Marcellus Formation brine to

    E-Print Network [OSTI]

    Geochemical evidence for possible natural migration of Marcellus Formation brine to shallow possible migration of Marcellus brine through naturally occurring pathways. The occurrences of saline water, because of natural hydraulic connections to deeper formations. formation water isotopes Marcellus Shale

  7. Transportation Energy Futures Series: Vehicle Technology Deployment Pathways: An Examination of Timing and Investment Constraints

    SciTech Connect (OSTI)

    Plotkin, S.; Stephens, T.; McManus, W.

    2013-03-01T23:59:59.000Z

    Scenarios of new vehicle technology deployment serve various purposes; some will seek to establish plausibility. This report proposes two reality checks for scenarios: (1) implications of manufacturing constraints on timing of vehicle deployment and (2) investment decisions required to bring new vehicle technologies to market. An estimated timeline of 12 to more than 22 years from initial market introduction to saturation is supported by historical examples and based on the product development process. Researchers also consider the series of investment decisions to develop and build the vehicles and their associated fueling infrastructure. A proposed decision tree analysis structure could be used to systematically examine investors' decisions and the potential outcomes, including consideration of cash flow and return on investment. This method requires data or assumptions about capital cost, variable cost, revenue, timing, and probability of success/failure, and would result in a detailed consideration of the value proposition of large investments and long lead times. This is one of a series of reports produced as a result of the Transportation Energy Futures (TEF) project, a Department of Energy-sponsored multi-agency effort to pinpoint underexplored strategies for abating GHGs and reducing petroleum dependence related to transportation.

  8. Use of comparative geothermometry to reconstruct burial history and timing of oil generation and migration in Niobrara Formation, Berthoud State 4 well, Denver basin, Colorado

    SciTech Connect (OSTI)

    Crysdale, B.L.; Barker, C.E. (Geological survey, Denver, CO (USA))

    1989-09-01T23:59:59.000Z

    Petroleum production from the Upper Cretaceous Niobrara limestone in the Denver basin is largely restricted to the more permeable, fractured portions of the formation. Berthoud State 4 well cores from about 880 to 975 m (2,900-3,200 ft) depth contain zoned calcite in nearly vertical veins. Primary two-phase oil inclusions in these veins homogenize at a mean temperature of about 85{degree}C. Mean random vitrinite-reflectance (R{sub m}) over this same depth interval is 0.65%. Interpretation of this R{sub m}, using an empirical calibration with peak burial-temperature (T{sub peak}), indicates that these rocks reached at T{sub peak} of approximately 100{degree}c. Published clay mineral assemblage data suggest T{sub peak} was at least 100{degree}c. Burial history reconstruction for Berthoud State 4 suggests T{sub peak} was reached about 70 Ma, quickly followed by a 30{degree}-40{degree}C decrease due to uplift and erosion of approximately 3,000 ft of overburden. This short time at peak burial temperature fixes the time of oil migration at near-maximum burial.

  9. September 2009 Migrating to

    E-Print Network [OSTI]

    Narasayya, Vivek

    September 2009 Migrating to Evaluator's Guide Windows Server 2008 R2 File Services #12;Evaluator's Guide: Migrating to Windows Server 2008 R2 File Services 5 Migrating to Windows Server 2008 R2 File Services IT Professionals hear a lot about the new, enticing features of Windows Server 2008 such as Active

  10. Making migration safer Policy Message

    E-Print Network [OSTI]

    Richner, Heinz

    : India, Kyrgyzstan, Nepal, Pakistan #12;.......................... Remittance economies in Asia Migration

  11. "Cut Me Some Slack": Latency-Aware Live Migration for Databases

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    by leveraging `migration slack', or resources that can be used for migration without excessively impacting query"Cut Me Some Slack": Latency-Aware Live Migration for Databases Sean Barker Yun Chi Hyun Jin Moon and exploit migration slack in real time. Using our prototype, we demonstrate that Slacker effectively

  12. Sound temporal envelope and time-patterns of activity in the human auditory pathway : an fMRI study

    E-Print Network [OSTI]

    Harms, Michael Patrick, 1972-

    2002-01-01T23:59:59.000Z

    The temporal envelope of sound strongly influences the intelligibility of speech, pattern analysis, and the grouping of sequential stimuli. This thesis examined the coding of sound temporal envelope in the time-patterns ...

  13. The C. elegans heterochronic pathway controls the timing of NAB/EGR-mediated terminal differentiation and the onset of adulthood

    E-Print Network [OSTI]

    Harris, David T. (David Taylor)

    2011-01-01T23:59:59.000Z

    Most animals pass through a series of juvenile stages on their way from embryo to adult. These stages represent periods of time in which stage-specific developmental processes occur. At the end of development, the organism ...

  14. GPER Inhibition of Coronary Artery Smooth Muscle Cell Migration and Proliferation

    E-Print Network [OSTI]

    Szynkarski, Claudia Kay

    2013-02-04T23:59:59.000Z

    in the pathogenesis of atherosclerosis, the leading cause of heart disease. GPER has been reported to inhibit VSMC proliferation but the mechanism and pathway is still unclear. Furthermore, an effect of GPER on coronary artery smooth muscle cell (CASMC) migration...

  15. The inhibitory effect of dexamethasone on platelet-derived growth factor-induced vascular smooth muscle cell migration through up-regulating PGC-1{alpha} expression

    SciTech Connect (OSTI)

    Xu, Wei [Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China) [Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China); Department of cardiology, the Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin 150081 (China); Guo, Ting; Zhang, Yan; Jiang, Xiaohong; Zhang, Yongxian [Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China)] [Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China); Zen, Ke, E-mail: kzen@nju.edu.cn [Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China)] [Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China); Yu, Bo, E-mail: yubodr@163.com [Department of cardiology, the Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin 150081 (China)] [Department of cardiology, the Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin 150081 (China); Zhang, Chen-Yu, E-mail: cyzhang@nju.edu.cn [Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China)] [Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093 (China)

    2011-05-01T23:59:59.000Z

    Dexamethasone has been shown to inhibit vascular smooth muscle cell (VSMC) migration, which is required for preventing restenosis. However, the mechanism underlying effect of dexamethasone remains unknown. We have previously demonstrated that peroxisome proliferator-activated receptor gamma (PPAR{gamma}) coactivator-1 alpha (PGC-1{alpha}) can inhibit VSMC migration and proliferation. Here, we investigated the role of PGC-1{alpha} in dexamethasone-reduced VSMC migration and explored the possible mechanism. We first examined PGC-1{alpha} expression in cultured rat aortic VSMCs. The results revealed that incubation of VSMCs with dexamethasone could significantly elevate PGC-1{alpha} mRNA expression. In contrast, platelet-derived growth factor (PDGF) decreased PGC-1{alpha} expression while stimulating VSMC migration. Mechanistic study showed that suppression of PGC-1{alpha} by small interfering RNA strongly abrogated the inhibitory effect of dexamethasone on VSMC migration, whereas overexpression of PGC-1{alpha} had the opposite effect. Furthermore, an analysis of MAPK signal pathways showed that dexamethasone inhibited ERK and p38 MAPK phosphorylation in VSMCs. Overexpression of PGC-1{alpha} decreased both basal and PDGF-induced p38 MAPK phosphorylation, but it had no effect on ERK phosphorylation. Finally, inhibition of PPAR{gamma} activation by a PPAR{gamma} antagonist GW9662 abolished the suppressive effects of PGC-1{alpha} on p38 MAPK phosphorylation and VSMC migration. These effects of PGC-1{alpha} were enhanced by a PPAR{gamma} agonist troglitazone. Collectively, our data indicated for the first time that one of the anti-migrated mechanisms of dexamethasone is due to the induction of PGC-1{alpha} expression. PGC-1{alpha} suppresses PDGF-induced VSMC migration through PPAR{gamma} coactivation and, consequently, p38 MAPK inhibition.

  16. Nepal Migration Year Book 2011 Migration Year Book

    E-Print Network [OSTI]

    Richner, Heinz

    Nepal Migration Year Book 2011 1 #12;Nepal Migration Year Book 2011 NIDS NCCR North-South #12;Book Nepal Migration Year Book 2011 Publishers Nepal Institute of Development Studies (NIDS) G.P.O. Box: 7647, Kathmandu, Nepal Email: nids@mail.com.np Web: www.nids.org.np National Centre of Competence in Research

  17. Method of migrating seismic records

    DOE Patents [OSTI]

    Ober, Curtis C. (Las Lunas, NM); Romero, Louis A. (Albuquerque, NM); Ghiglia, Dennis C. (Longmont, CO)

    2000-01-01T23:59:59.000Z

    The present invention provides a method of migrating seismic records that retains the information in the seismic records and allows migration with significant reductions in computing cost. The present invention comprises phase encoding seismic records and combining the encoded seismic records before migration. Phase encoding can minimize the effect of unwanted cross terms while still allowing significant reductions in the cost to migrate a number of seismic records.

  18. A Multidisciplinary Approach To Detect Active Pathways For Magma Migration

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to:Ezfeedflag JumpID-fTriWildcat 1 WindtheEnergy InformationOf The 28-29 MarchIsland,

  19. Oil migration pattern in the Sirte Basin

    SciTech Connect (OSTI)

    Roohi, M.; Aburawi, R.M. [Waha Oil Co., Tripoli (Libyan Arab Jamahiriya)

    1995-08-01T23:59:59.000Z

    Sirte Basin is an asymmetrical cratonic basin, situated in the north-central part of Libya. It covers an area of over 350,000km{sup 2} and is one of the most prolific oil-producing basins in the world. Sirte Basin is divided into large NW-SE trending sub-parallel platforms and troughs bounded by deep seated syndepositional normal faults. A very unique combination of thick sediments with rich source rocks in the troughs vs. thinner sediments with prolific reservoir rocks on the platforms accounts for the productivity of the basin. Analysis of oil migration pattern in the Sirte Basin will certainly help to discover the remaining reserves, and this can only be achieved if the important parameter of structural configuration of the basin at the time of oil migration is known. The present paper is an attempt to analyse the time of oil migration, to define the structural picture of the 4 Basin during the time of migration and to delineate the most probable connecting routes between the hydrocarbon kitchens and the oil fields.

  20. Caged phosphopeptides and phosphoproteins : probes to dissect the role of phosphorylation in complex signaling pathways

    E-Print Network [OSTI]

    Vogel, Elizabeth Maura

    2007-01-01T23:59:59.000Z

    Protein phosphorylation is a central regulatory mechanism in signal transduction pathways and cellular migration. Current genetic strategies for the study of phosphorylation, including gene knockout and point mutation, are ...

  1. Giant Planet Migration in Viscous Power-Law Discs

    E-Print Network [OSTI]

    R. G. Edgar

    2007-04-03T23:59:59.000Z

    Many extra-solar planets discovered over the past decade are gas giants in tight orbits around their host stars. Due to the difficulties of forming these `hot Jupiters' in situ, they are generally assumed to have migrated to their present orbits through interactions with their nascent discs. In this paper, we present a systematic study of giant planet migration in power law discs. We find that the planetary migration rate is proportional to the disc surface density. This is inconsistent with the assumption that the migration rate is simply the viscous drift speed of the disc. However, this result can be obtained by balancing the angular momentum of the planet with the viscous torque in the disc. We have verified that this result is not affected by adjusting the resolution of the grid, the smoothing length used, or the time at which the planet is released to migrate.

  2. Curvature Capillary Migration of Microspheres

    E-Print Network [OSTI]

    Nima Sharifi-Mood; Iris B. Liu; Kathleen J. Stebe

    2015-05-11T23:59:59.000Z

    We address the question: How does capillarity propel microspheres along curvature gradients? For a particle on a fluid interface, there are two conditions that can apply at the three phase contact line: Either the contact line adopts an equilibrium contact angle, or it can be pinned by kinetic trapping, e.g. at chemical heterogeneities, asperities or other pinning sites on the particle surface. We formulate the curvature capillary energy for both scenarios for particles smaller than the capillary length and far from any pinning boundaries. The scale and range of the distortion made by the particle are set by the particle radius; we use singular perturbation methods to find the distortions and to rigorously evaluate the associated capillary energies. For particles with equilibrium contact angles, contrary to the literature, we find that the capillary energy is negligible, with the first contribution bounded to fourth order in the product of the particle radius and the deviatoric curvature. For pinned contact lines, we find curvature capillary energies that are finite, with a functional form investigated previously by us for disks and microcylinders on curved interfaces. In experiments, we show microsphere migrate along deterministic trajectories toward regions of maximum deviatoric curvature with curvature capillary energies ranging from $6 \\times10^3 - 5 \\times 10^4~k_BT$. These data agree with the curvature capillary energy for the case of pinned contact lines. The underlying physics of this migration is a coupling of the interface deviatoric curvature with the quadrupolar mode of nanometric disturbances in the interface owing to the particle's contact line undulations. This work is an example of the major implications of nanometric roughness and contact line pinning for colloidal dynamics.

  3. Peripheral blood derived mononuclear cells enhance osteoarthritic human chondrocyte migration

    E-Print Network [OSTI]

    Hopper, Niina; Henson, Frances; Brooks, Roger; Ali, Erden; Rushton, Neil; Wardale, John

    2015-01-01T23:59:59.000Z

    gradients [44, 45]. Experiments in young animals have shown that chondrocyte migration affects tissue-engineered cartilage integration by activating the signal transduction pathways involving Src, PLC?1, and ERK1/2 [46]. In order to begin to investigate... from the National Institute for Health Research. Abbreviations ACTB, actin beta; B2M, beta-2 microglobulin; BMP, bone morphogenic protein; CAPN, calpain; CI, cell index; ECM, extracellular matrix; ERK, extracellular signal regulated kinases; FBS...

  4. Type I planet migration in nearly laminar disks

    SciTech Connect (OSTI)

    Li, Hui [Los Alamos National Laboratory; Li, Shengtai [Los Alamos National Laboratory; Lubow, S H [STSI; Lin, D [UCSC

    2008-01-01T23:59:59.000Z

    We describe two-dimensional hydrodynamic simulations of the migration of low-mass planets ({<=}30 M{sub {circle_plus}}) in nearly laminar disks (viscosity parameter {alpha} < 10{sup -3}) over timescales of several thousand orbit periods. We consider disk masses of 1, 2, and 5 times the minimum mass solar nebula, disk thickness parameters of H/r = 0.035 and 0.05, and a variety of {alpha} values and planet masses. Disk self-gravity is fully included. Previous analytic work has suggested that Type I planet migration can be halted in disks of sufficiently low turbulent viscosity, for {alpha} {approx} 10{sup -4}. The halting is due to a feedback effect of breaking density waves that results in a slight mass redistribution and consequently an increased outward torque contribution. The simulations confirm the existence of a critical mass (M{sub {alpha}} {approx} 10M{sub {circle_plus}}) beyond which migration halts in nearly laminar disks. For {alpha} {approx}> 10{sup -3}, density feedback effects are washed out and Type I migration persists. The critical masses are in good agreement with the analytic model of Rafikov. In addition, for {alpha} {approx}> 10{sup -4} steep density gradients produce a vortex instability, resulting in a small time-varying eccentricity in the planet's orbit and a slight outward migration. Migration in nearly laminar disks may be sufficiently slow to reconcile the timescales of migration theory with those of giant planet formation in the core accretion model.

  5. Lumican induces human corneal epithelial cell migration and integrin expression via ERK 1/2 signaling

    SciTech Connect (OSTI)

    Seomun, Young [Laboratory of Ophthalmology and Visual Science, Korean Eye Tissue and Gene Bank related to Blindness, College of Medicine, Catholic University of Korea, 505 Banpo-dong, Seocho-ku, Seoul 137-040 (Korea, Republic of); Joo, Choun-Ki [Laboratory of Ophthalmology and Visual Science, Korean Eye Tissue and Gene Bank related to Blindness, College of Medicine, Catholic University of Korea, 505 Banpo-dong, Seocho-ku, Seoul 137-040 (Korea, Republic of)], E-mail: ckjoo@catholic.ac.kr

    2008-07-18T23:59:59.000Z

    Lumican is a major proteoglycans of the human cornea. Lumican knock-out mice have been shown to lose corneal transparency and to display delayed wound healing. The purpose of this study was to define the role of lumican in corneal epithelial cell migration. Over-expression of lumican in human corneal epithelial (HCE-T) cells increased both cell migration and proliferation, and increased levels of integrins {alpha}2 and {beta}1. ERK 1/2 was also activated in lumican over-expressed cells. When we treated HCE-T cells with the ERK-specific inhibitor U0126, cell migration and the expression of integrin {beta}1 were completely blocked. These data provide evidence that lumican stimulates cell migration in the corneal epithelium by activating ERK 1/2, and point to a novel signaling pathway implicated in corneal epithelial cell migration.

  6. Preliminary investigation of the nature of hydrocarbon migration and entrapment

    E-Print Network [OSTI]

    Bai, Jianyong

    2004-09-30T23:59:59.000Z

    production while another half sealed among them. The Ship Shoal 274 reservoirs have exhibited a complex history of migration and entrapment. An early stage of oil and gas charge was followed and disturbed by late stage gas migration, mainly 8 through growth... structures. The charge time for commercial hydrocarbon accumulation is much longer in oil-water systems than in oil-gas-water systems. Faults are classified into charging faults and ?back doors? ? faults other than charging faults in stacked fault...

  7. Estimates of potential radionuclide migration at the Bullion site

    SciTech Connect (OSTI)

    Brikowski, T.H.

    1992-04-01T23:59:59.000Z

    The Bullion site in Area 20 of the Nevada Test Site has been selected for an intensive study of the hydrologic consequences of underground testing, including subsequent radionuclide migration. The bulk of the chimney and cavity lie in zeolitized tuffs of low hydraulic conductivity, while the base of the cavity may extend downward into more conductive rhyolite flows. A mathematical analog to the Bullion setting is used here to estimate expected radionuclide migration rates and concentrations. Because of a lack of hydrologic data at the site, two contrasting scenarios are considered. The first is downward-transport, in which downward hydraulic gradients flush chimney contents into the conductive underlying units, enhancing migration. The other is upward-transport, in which upward gradients tend to drive chimney contents into the low-conductivity zeolitized tuffs, discouraging migration. In the downward-transport scenario, radionuclide travel times and concentrations are predicted to be similar to those encountered at Cheshire, requiring approximately 10 years to reach a proposed well 300 m downgradient. The upward transport scenario yields predicted travel times on the order of 2,000 years to the downgradient well. The most likely scenario is a combination of these results, with vertical movement playing a limited role. Radionuclides injected directly into the rhyolites should migrate laterally very quickly, with travel times as in the downward-transport scenario. Those in the zeolitized tuff-walled portion of the chimney should migrate extremely slowly, as in the upward-transport scenario.

  8. A life-course perspective on U.S. migration experience and later-life diabetes, hypertension, and depression for middle-aged and older Mexican adults

    E-Print Network [OSTI]

    Torres, Jacqueline Marie

    2014-01-01T23:59:59.000Z

    pathways to adult-onset diabetes. Soc Biol, 52(3-4), 94-111.by older Mexicans with diabetes: how migration to the UnitedG. (2010). Social determinants of diabetes and challenges of

  9. Monitoring and Evaluation of Smolt Migration in the Columbia Basin, Volume XIV; Evaluation of 2006 Prediction of the Run-Timing of Wild and Hatchery-Reared Salmon and Steelhead at Rock Island, Lower Granite, McNary, John Day and Bonneville Dams using Program Real Time, Technical Report 2006.

    SciTech Connect (OSTI)

    Griswold, Jim

    2007-01-01T23:59:59.000Z

    Program RealTime provided monitoring and forecasting of the 2006 inseason outmigrations via the internet for 32 PIT-tagged stocks of wild ESU chinook salmon and steelhead to Lower Granite and/or McNary dams, one PIT-tagged hatchery-reared ESU of sockeye salmon to Lower Granite Dam, and 20 passage-indexed runs-at-large, five each to Rock Island, McNary, John Day, and Bonneville Dams. Twenty-four stocks are of wild yearling chinook salmon which were captured, PIT-tagged, and released at sites above Lower Granite Dam in 2006, and have at least one year's historical migration data previous to the 2006 migration. These stocks originate in drainages of the Salmon, Grande Ronde and Clearwater Rivers, all tributaries to the Snake River, and are subsequently detected through the tag identification and monitored at Lower Granite Dam. In addition, seven wild PIT-tagged runs-at-large of Snake or Upper Columbia River ESU salmon and steelhead were monitored at McNary Dam. Three wild PIT-tagged runs-at-large were monitored at Lower Granite Dam, consisting of the yearling and subyearling chinook salmon and the steelhead trout runs. The hatchery-reared PIT-tagged sockeye salmon stock from Redfish Lake was monitored outmigrating through Lower Granite Dam. Passage-indexed stocks (stocks monitored by FPC passage indices) included combined wild and hatchery runs-at-large of subyearling and yearling chinook, coho, and sockeye salmon, and steelhead trout forecasted to Rock Island, McNary, John Day, and Bonneville Dams.

  10. Monitoring and Evaluation of Smolt Migration in the Columbia Basin : Volume XV : Evaluation of the 2007 Predictions of the Run-Timing of Wild and Hatchery-Reared Salmon and Steelhead Smolts to Rock Island, Lower Granite, McNary, John Day, and Bonneville Dams using Program RealTime.

    SciTech Connect (OSTI)

    Griswold, Jim; Townsend, Richard L.; Skalski, John R.

    2008-12-01T23:59:59.000Z

    Program RealTime provided monitoring and forecasting of the 2007 inseason outmigrations via the internet for 26 PIT-tagged stocks of wild ESU Chinook salmon and steelhead to Lower Granite and/or McNary dams, one PIT-tagged hatchery-reared ESU of sockeye salmon to Lower Granite Dam, one PIT-tagged wild stock of sockeye salmon to McNary Dam, and 20 passage-indexed runs-at-large, five each to Rock Island, McNary, John Day, and Bonneville dams. Nineteen stocks are of wild yearling Chinook salmon which were captured, PIT-tagged, and released at sites above Lower Granite Dam in 2007 and have at least one year's historical migration data previous to the 2007 migration. These stocks originate in 19 tributaries of the Salmon, Grande Ronde and Clearwater Rivers, all tributaries to the Snake River, and are subsequently detected through tag identification and monitored at Lower Granite Dam. Seven wild PIT-tagged runs-at-large of Snake or Upper Columbia River ESU salmon and steelhead were monitored at McNary Dam. Three wild PIT-tagged runs-at-large were monitored at Lower Granite Dam, consisting of the yearling and subyearling Chinook salmon and the steelhead runs. The hatchery-reared PIT-tagged sockeye salmon stock from Redfish Lake was monitored outmigrating through Lower Granite Dam. Passage-indexed stocks (stocks monitored by FPC passage indices) included combined wild and hatchery runs-at-large of subyearling and yearling Chinook, coho, and sockeye salmon, and steelhead forecasted to Rock Island, McNary, John Day, and Bonneville dams.

  11. Directly Imaging Tidally Powered Migrating Jupiters

    E-Print Network [OSTI]

    Dong, Subo; Socrates, Aristotle

    2012-01-01T23:59:59.000Z

    We show that ongoing direct imaging experiments may detect a new class of long-period, highly luminous, tidally powered extrasolar gas giants. Even though they are hosted by Gyr-"old" main-sequence stars, they can be as "hot" as young Jupiters at ~100 Myr, the prime targets of direct imaging surveys. These planets, with years-long orbits, are presently migrating to "feed" the "hot Jupiters" in steady state. Their existence is expected from a class of "high-e" migration mechanisms, in which gas giants are excited to highly eccentric orbits and then shrink their semi-major axis by factor of ~ 10-100 due to tidal dissipation at successive close periastron passages. The dissipated orbital energy is converted to heat, and if it is deposited deep enough into the planet atmosphere, the planet likely radiates steadily at luminosity ~2-3 orders of magnitude larger than that of our Jupiter during a typical Gyr migration time scale. Their large orbital separations and expected high planet-to-star flux ratios in IR make ...

  12. A modeling of buoyant gas plume migration

    SciTech Connect (OSTI)

    Silin, D.; Patzek, T.; Benson, S.M.

    2008-12-01T23:59:59.000Z

    This work is motivated by the growing interest in injecting carbon dioxide into deep geological formations as a means of avoiding its atmospheric emissions and consequent global warming. Ideally, the injected greenhouse gas stays in the injection zone for a geologic time, eventually dissolves in the formation brine and remains trapped by mineralization. However, one of the potential problems associated with the geologic method of sequestration is that naturally present or inadvertently created conduits in the cap rock may result in a gas leakage from primary storage. Even in a supercritical state, the carbon dioxide viscosity and density are lower than those of the formation brine. Buoyancy tends to drive the leaked CO{sub 2} plume upward. Theoretical and experimental studies of buoyancy-driven supercritical CO{sub 2} flow, including estimation of time scales associated with plume evolution and migration, are critical for developing technology, monitoring policy, and regulations for safe carbon dioxide geologic sequestration. In this study, we obtain simple estimates of vertical plume propagation velocity taking into account the density and viscosity contrast between CO{sub 2} and brine. We describe buoyancy-driven countercurrent flow of two immiscible phases by a Buckley-Leverett type model. The model predicts that a plume of supercritical carbon dioxide in a homogeneous water-saturated porous medium does not migrate upward like a bubble in bulk water. Rather, it spreads upward until it reaches a seal or until it becomes immobile. A simple formula requiring no complex numerical calculations describes the velocity of plume propagation. This solution is a simplification of a more comprehensive theory of countercurrent plume migration (Silin et al., 2007). In a layered reservoir, the simplified solution predicts a slower plume front propagation relative to a homogeneous formation with the same harmonic mean permeability. In contrast, the model yields much higher plume propagation estimates in a high-permeability conduit like a vertical fracture.

  13. adam2 promotes migration: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    migrative schedule Amir, Amihood 369 How to Migrate Agents Lambda Matthew Hohlfeld y Bennet Yee z Computer Technologies and Information Sciences Websites Summary: How to Migrate...

  14. amplicon promotes migration: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    migrative schedule Amir, Amihood 374 How to Migrate Agents Lambda Matthew Hohlfeld y Bennet Yee z Computer Technologies and Information Sciences Websites Summary: How to Migrate...

  15. "To Have and Have Not" Migration, Remittances, Poverty and Inequality in Algeria

    E-Print Network [OSTI]

    Boyer, Edmond

    1 "To Have and Have Not" Migration, Remittances, Poverty and Inequality in Algeria David Margolis in Idjeur being twice as large as Nedroma. At the same time, they help reduce poverty by nearly 13 that the latter do not send money home. Keywords: Remittances, Migration, Poverty, Inequality, Algeria

  16. RIS-M-2260 HEAT GRADIENT INDUCED MIGRATION OF BRINE INCLUSIONS IN ROCK SALT

    E-Print Network [OSTI]

    RISØ-M-2260 HEAT GRADIENT INDUCED MIGRATION OF BRINE INCLUSIONS IN ROCK SALT Mathematical treatment project. Abstract. A mathematical model for the brine migration in rock salt around an infinite line heat source is set up. The tempera- ture field around the time dependent heat source is calculated by use

  17. Interleukin-6 triggers human cerebral endothelial cells proliferation and migration: The role for KDR and MMP-9

    SciTech Connect (OSTI)

    Yao, Jianhua S. [Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110 (United States); Zhai Wenwu [Department of Lung Biology, University of California, San Francisco, CA 94110 (United States); Young, William L. [Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110 (United States); Department of Neurological Surgery, University of California, San Francisco, CA 94110 (United States); Department of Neurology, University of California, San Francisco, CA 94110 (United States); Yang Guoyuan [Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110 (United States) and Department of Neurological Surgery, University of California, San Francisco, CA 94110 (United States)]. E-mail: gyyang@anesthesia.ucsf.edu

    2006-04-21T23:59:59.000Z

    Interleukin-6 (IL-6) is involved in angiogenesis. However, the underlying mechanisms are unknown. Using human cerebral endothelial cell (HCEC), we report for First time that IL-6 triggers HCEC proliferation and migration in a dose-dependent manner, specifically associated with enhancement of VEGF expression, up-regulated and phosphorylated VEGF receptor-2 (KDR), and stimulated MMP-9 secretion. We investigated the signal pathway of IL-6/IL-6R responsible for KDR's regulation. Pharmacological inhibitor of PI3K failed to inhibit IL-6-mediated VEGF overexpression, while blocking ERK1/2 with PD98059 could abolish IL-6-induced KDR overexpression. Further, neutralizing endogenous VEGF attenuated KDR expression and phosphorylation, suggesting that IL-6-induced KDR activation is independent of VEGF stimulation. MMP-9 inhibitor GM6001 significantly decreases HCEC proliferation and migration (p < 0.05), indicating the crucial function of MMP-9 in promoting angiogenic changes in HCECs. We conclude that IL-6 triggers VEGF-induced angiogenic activity through increasing VEGF release, up-regulates KDR expression and phosphorylation through activating ERK1/2 signaling, and stimulates MMP-9 overexpression.

  18. LATERAL LANDFILL GAS MIGRATION: CHARACTERIZATION AND

    E-Print Network [OSTI]

    Boyer, Edmond

    LATERAL LANDFILL GAS MIGRATION: CHARACTERIZATION AND PRELIMINARY MODELING RESULTS O.BOUR*, E,UniversitéLaval, Sainte-Foy, Canada SUMMARY: Lateral landfill gas migration occurs in the surroundings of a MSW landfill complementary physical measures were used to build a conceptual model of lateral landfill gas migration

  19. Employment Protection and Migration$ Remi Bazillier

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Employment Protection and Migration$ R´emi Bazillier LEO-CNRS (UMR 7322), Universit´e d particularly employment protection (EPL), are an important determinant of migration. Us- ing a bilateral migration database, we empirically show that the employment protection differential has a negative impact

  20. Essays on rural-urban migration in hinterland China

    E-Print Network [OSTI]

    Meng, Lei

    2009-01-01T23:59:59.000Z

    Marriage Rates in Rural China . . . . . . . . . . .Urban Migration in Hinterland China . . . . . . . . . .and Rural-Urban Migration in Hinterland China . . . . . 1.

  1. Climate Vision: Technology Pathways

    Office of Scientific and Technical Information (OSTI)

    Cement Chemical Manufacturing Electric Power Forest Products Iron and Steel Mining Oil and Gas Technology Pathways The DOE's Industries of the Future process helps...

  2. Scattering and; Delay, Scale, and Sum Migration

    SciTech Connect (OSTI)

    Lehman, S K

    2011-07-06T23:59:59.000Z

    How do we see? What is the mechanism? Consider standing in an open field on a clear sunny day. In the field are a yellow dog and a blue ball. From a wave-based remote sensing point of view the sun is a source of radiation. It is a broadband electromagnetic source which, for the purposes of this introduction, only the visible spectrum is considered (approximately 390 to 750 nanometers or 400 to 769 TeraHertz). The source emits an incident field into the known background environment which, for this example, is free space. The incident field propagates until it strikes an object or target, either the yellow dog or the blue ball. The interaction of the incident field with an object results in a scattered field. The scattered field arises from a mis-match between the background refractive index, considered to be unity, and the scattering object refractive index ('yellow' for the case of the dog, and 'blue' for the ball). This is also known as an impedance mis-match. The scattering objects are referred to as secondary sources of radiation, that radiation being the scattered field which propagates until it is measured by the two receivers known as 'eyes'. The eyes focus the measured scattered field to form images which are processed by the 'wetware' of the brain for detection, identification, and localization. When time series representations of the measured scattered field are available, the image forming focusing process can be mathematically modeled by delayed, scaled, and summed migration. This concept of optical propagation, scattering, and focusing have one-to-one equivalents in the acoustic realm. This document is intended to present the basic concepts of scalar scattering and migration used in wide band wave-based remote sensing and imaging. The terms beamforming and (delayed, scaled, and summed) migration are used interchangeably but are to be distinguished from the narrow band (frequency domain) beamforming to determine the direction of arrival of a signal, and seismic migration in which wide band time series are shifted but not to form images per se. Section 3 presents a mostly graphically-based motivation and summary of delay, scale, and sum beamforming. The model for incident field propagation in free space is derived in Section 4 under specific assumptions. General object scattering is derived in Section 5 and simplified under the Born approximation in Section 6. The model of this section serves as the basis in the derivation of time-domain migration. The Foldy-Lax, full point scatterer scattering, method is derived in Section 7. With the previous forward models in hand, delay, scale, and sum beamforming is derived in Section 8. Finally, proof-of-principle experiments are present in Section 9.

  3. ORBITAL MIGRATION OF LOW-MASS PLANETS IN EVOLUTIONARY RADIATIVE MODELS: AVOIDING CATASTROPHIC INFALL

    SciTech Connect (OSTI)

    Lyra, Wladimir; Mac Low, Mordecai-Mark [Department of Astrophysics, American Museum of Natural History, 79th Street at Central Park West, New York, NY 10024 (United States); Paardekooper, Sijme-Jan, E-mail: wlyra@amnh.or, E-mail: mordecai@amnh.or [Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge CB3 OWA (United Kingdom)

    2010-06-01T23:59:59.000Z

    Outward migration of low-mass planets has recently been shown to be a possibility in non-barotropic disks. We examine the consequences of this result in evolutionary models of protoplanetary disks. Planet migration occurs toward equilibrium radii with zero torque. These radii themselves migrate inwards because of viscous accretion and photoevaporation. We show that as the surface density and temperature fall the planet orbital migration and disk depletion timescales eventually become comparable, with the precise timing depending on the mass of the planet. When this occurs, the planet decouples from the equilibrium radius. At this time, however, the gas surface density is already too low to drive substantial further migration. A higher mass planet, of 10 M {sub +}, can open a gap during the late evolution of the disk, and stops migrating. Low-mass planets, with 1 or 0.1 M {sub +}, released beyond 1 AU in our models avoid migrating into the star. Our results provide support for the reduced migration rates adopted in recent planet population synthesis models.

  4. Charge migration in organic materials: Can propagating charges affect the key physical quantities controlling their motion?

    E-Print Network [OSTI]

    Gollub, C; Gutierrez, R; Berlin, Y; Cuniberti, G

    2012-01-01T23:59:59.000Z

    Charge migration is a ubiquitous phenomenon with profound implications throughout many areas of chemistry, physics, biology and materials science. The long-term vision of designing functional materials with tailored molecular scale properties has triggered an increasing quest to identify prototypical systems where truly molecular conduction pathways play a fundamental role. Such pathways can be formed due to the molecular organization of various organic materials and are widely used to discuss electronic properties at the nanometer scale. Here, we present a computational methodology to study charge propagation in organic molecular stacks at nano and sub-nanoscales and exploit this methodology to demonstrate that moving charge carriers strongly affect the values of the physical quantities controlling their motion. The approach is also expected to find broad application in the field of charge migration in soft matter systems.

  5. Wrenching and oil migration, Mervine field, Kay County, Oklahoma

    SciTech Connect (OSTI)

    Davis, H.G.

    1985-02-01T23:59:59.000Z

    Since 1913, Mervine field (T27N, R3E) has produced oil from 11 Mississippian and Pennsylvanian zones, and gas from 2 Permian zones. The field exhibits an impressive asymmetric surface anticline, with the steeper flank dipping 30/sup 0/E maximum. A nearly vertical, basement-involved fault develops immediately beneath the steeper flank of the surface anticline. Three periods of left-lateral wrench faulting account for 93% of all structural growth: 24% in post-Mississippian-pre-Desmoinesian time, 21% in Virgilian time, and 48% in post-Wolfcampian time. In Mesozoic through early Cenozoic times, the Devonian Woodford Shale (and possibly the Desmoinesian Cherokee shales) locally generated oil, which should have been structurally trapped in the Ordovician Bromide sandstone. This oil may have joined oil already trapped in the Bromide, which had migrated to the Mervine area in the Early Pennsylvanian from a distant source. Intense post-Wolfcampian movement(s) fractured the competent pre-Pennsylvanian rocks, allowing Bromide brine and entrained oil to migrate vertically up the master fault, finally accumulating in younger reservoirs. Pressure, temperature, and salinity anomalies attest to vertical fluid migration continuing at the present time at Mervine field. Consequently, pressure, temperature, and salinity mapping should be considered as valuable supplements to structural and lithologic mapping when prospecting for structural hydrocarbon accumulations in epicratonic provinces.

  6. Fluorescent growth bands in irradiated-bitumen nodules: Evidence of episodic hydrocarbon migration

    SciTech Connect (OSTI)

    Rasmussen, B. [Univ. of Western Australia, Nedlands (Australia)

    1997-01-01T23:59:59.000Z

    Minute rims of solid bitumen ({approximately}40-50 {mu}m thick) surround detrital radioactive grains in the Permian-Triassic sandstones and Arranoo Member of the Kockatea Shale from the northern Perth basin, Australia. The bitumen formed as Th- and U-bearing minerals (monazite, xenotime, zircon, thorite) irradiated and immobilized fluid hydrocarbons coming within range of alpha-particle emissions. using transmitted light and scanning electron microscopy and rims appear compositionally homogeneous, but under blue/violet epifluorescent illumination the bitumen displays complex concentric and contorted banding. These fluorescent textures indicate that multiple influxes of hydrocarbons passed through the reservoir sandstones. Following radiation-induced immobilization of hydrocarbons from the first oil influx, the bitumen nodules grew through a process of swelling and expansion outward form the mineral core during subsequent oil influxes, producing graded fluorescent growth bands. Oil droplets and lamellae also were adsorbed onto the outer portion of the nodules. Such bitumen nodules are a new and potentially important source of data for understanding the movement of hydrocarbons in sedimentary basins, specifically for identifying hydrocarbon pathways, the number of discrete hydrocarbon pulses, and the relative timing of oil migration.

  7. Migrating Contaminant Sticks To Minerals | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Migrating Contaminant Sticks To Minerals Aluminum oxide in common soil minerals captures uranium Using computational chemistry models, scientists at Pacific Northwest National...

  8. Migration and Development Research Scoping Study

    E-Print Network [OSTI]

    Boyer, Edmond

    , poverty, inequality and growth....................................................... 3 2.3. Socio the effects of migration and remittances on development indicators such as poverty, health, inequality, income

  9. Essays on migration and monetary policy

    E-Print Network [OSTI]

    Borger, Scott Charles

    2009-01-01T23:59:59.000Z

    6] Hanson, G.H. (2006): “Illegal Migration from Mexico toSpilimbergo. (1999): “Illegal Immigration, Border Enforce-Effects of Enforcement on Illegal Markets: Evidence from

  10. Evolution of Migrating Planets Undergoing Gas Accretion

    E-Print Network [OSTI]

    Gennaro D'Angelo; Stephen H. Lubow

    2008-06-11T23:59:59.000Z

    We analyze the orbital and mass evolution of planets that undergo run-away gas accretion by means of 2D and 3D hydrodynamic simulations. The disk torque distribution per unit disk mass as a function of radius provides an important diagnostic for the nature of the disk-planet interactions. We first consider torque distributions for nonmigrating planets of fixed mass and show that there is general agreement with the expectations of resonance theory. We then present results of simulations for mass-gaining, migrating planets. For planets with an initial mass of 5 Earth masses, which are embedded in disks with standard parameters and which undergo run-away gas accretion to one Jupiter mass (Mjup), the torque distributions per unit disk mass are largely unaffected by migration and accretion for a given planet mass. The migration rates for these planets are in agreement with the predictions of the standard theory for planet migration (Type I and Type II migration). The planet mass growth occurs through gas capture within the planet's Bondi radius at lower planet masses, the Hill radius at intermediate planet masses, and through reduced accretion at higher planet masses due to gap formation. During run-away mass growth, a planet migrates inwards by only about 20% in radius before achieving a mass of ~1 Mjup. For the above models, we find no evidence of fast migration driven by coorbital torques, known as Type III migration. We do find evidence of Type III migration for a fixed mass planet of Saturn's mass that is immersed in a cold and massive disk. In this case the planet migration is assumed to begin before gap formation completes. The migration is understood through a model in which the torque is due to an asymmetry in density between trapped gas on the leading side of the planet and ambient gas on the trailing side of the planet.

  11. Migrating Songbirds Recalibrate Their Magnetic Compass Daily

    E-Print Network [OSTI]

    Murphy, Troy G.

    Migrating Songbirds Recalibrate Their Magnetic Compass Daily from Twilight Cues William W. Cochran, the same individuals migrated northward again. We suggest that birds orient with a magnetic compass­3) after a voyage of up to 25,000 km (4, 5). Migratory songbirds can orient on the basis of compass

  12. Helium Migration in Iron Christ's College

    E-Print Network [OSTI]

    Cambridge, University of

    Helium Migration in Iron Y. Zhang Christ's College Department of Materials Science and Metallurgy the achievement at all. ii #12;Abstract A theoretical model of helium migration in body centred cubic (BCC)structure irons has been developed using the concept of the effective helium diffusion coeffi- cient

  13. A Survey of Process Migration Mechanisms Jonathan M. Smith

    E-Print Network [OSTI]

    Smith, Jonathan M.

    A Survey of Process Migration Mechanisms Jonathan M. Smith Computer Science Department Columbia Migration Mechanisms Jonathan M. Smith Computer Science Department Columbia University New York, NY 10027

  14. NETL Gas Migration Study to Advance Understanding of Responsible...

    Office of Environmental Management (EM)

    Gas Migration Study to Advance Understanding of Responsible Oil and Natural Gas Development NETL Gas Migration Study to Advance Understanding of Responsible Oil and Natural Gas...

  15. Environmental Science: Sample Pathway

    E-Print Network [OSTI]

    Goldberg, Bennett

    Environmental Science: Sample Pathway Semester I Semester II Freshman Year CGS Core CGS Core GE 100 & 124) MA 115 Statistics Summer Environmental Internship Junior Year CH 171 Chem for Health Sciences CH in Environmental Sciences is 17 courses. Courses taken to satisfy CAS major requirements (required, principal, core

  16. Transverse Entanglement Migration in Hilbert Space

    E-Print Network [OSTI]

    K. W. Chan; J. P. Torres; J. H. Eberly

    2007-04-18T23:59:59.000Z

    We show that, although the amount of mutual entanglement of photons propagating in free space is fixed, the type of correlations between the photons that determine the entanglement can dramatically change during propagation. We show that this amounts to a migration of entanglement in Hilbert space, rather than real space. For the case of spontaneous parametric down conversion, the migration of entanglement in transverse coordinates takes place from modulus to phase of the bi-photon state and back again. We propose an experiment to observe this migration in Hilbert space and to determine the full entanglement.

  17. Pb-Pb dating of hydrocarbon migration into a bitumen-bearing ore deposit, North Wales

    SciTech Connect (OSTI)

    Parnell, J. (Queens's Univ., Belfast (Ireland)); Swainbank, I. (NERC Isotope Geology Centre, Nottingham (England))

    1990-10-01T23:59:59.000Z

    Previous attempts at U-Pb dating of uraniferous bitumens have had limited significance because of radioelement migration. Pb-Pb dating which can be undertaken regardless of recent lead migration, has been successfully applied to uraniferous solidified bitumen from the Ty Gwyn copper deposit, North Wales. Analyses of five bitumen samples with variable mixtures of radiogenic and common lead yield a {sup 207}Pb/{sup 206}Pb age of 248 {plus minus} 21 Ma (Early Triassic). This age is interpreted as the date of hydrocarbon migration into the deposit and is reasonably consistent with the timing of hydrocarbon generation calculated from the regional burial history. The Pb-Pb dating method could be applied to date uraniferous bitumens representing hydrocarbon migration in diverse geologic environments.

  18. Pathway and Resource Overview (Presentation)

    SciTech Connect (OSTI)

    Ruth, M. F.

    2009-11-16T23:59:59.000Z

    This presentation provides information about hydrogen pathway analysis, which is analysis of the total levelized cost (including return on investment). Well-to-wheels (WTW) energy use, and WTW emissions for hydrogen production, delivery, and distribution pathways.

  19. Chemical Tools for Studying Directed Cell Migration

    E-Print Network [OSTI]

    Goguen, Brenda N.

    Cell migration is required for many physiological processes, including wound repair and embryogenesis, and relies on precisely orchestrated events that are regulated in a spatially and temporally controlled manner. Most ...

  20. NAWIPS Migration to AWIPS II Status Update

    E-Print Network [OSTI]

    ­ Migrating to new architecture · Leveraged Raytheon implementations where possible · Take advantage/Integration · Software to be base-lined via Raytheon task ­ Drops will be more frequent - available for Center

  1. PMI Toolbox User's Guide Photon Migration Imaging

    E-Print Network [OSTI]

    Boas, David

    PMI Toolbox User's Guide 2/25/2002 1 Photon Migration Imaging Toolbox 2001 http Temple Place - Suite 330, Boston, MA 02111-1307, USA. http://www.gnu.org/copyleft/gpl.html #12;PMI

  2. Immigration Control in the Age of Migration

    E-Print Network [OSTI]

    Wong, Tak Kei

    2011-01-01T23:59:59.000Z

    to 2003 and 2007 to 2008), Malta (2007), and Norway (2009).022). MIGRATION From 2000 to 2009, Malta received a total ofby 1,446 percent. In 2000, Malta received 450 immigrants. In

  3. Tackling Global Inequality in Labor Migration: Diaspora Mechanism and Migration Development Bank

    E-Print Network [OSTI]

    Gevorkyan, Aleksandr V.; Gevorkyan, Arkady V.

    2007-01-01T23:59:59.000Z

    Tackling Global Inequality in Labor Migration: DiasporaCruz Conference on “Mapping Global Inequalities - BeyondIncome Inequality” * November 17, 2007 New York, NY

  4. Birds see the trees inside the forest: The potential impacts of changes in forest composition on songbirds during spring migration

    E-Print Network [OSTI]

    Turner, Monica G.

    on songbirds during spring migration Eric M. Wood , Anna M. Pidgeon, Feng Liu, David J. Mladenoff Department time in the life cycle of migratory songbirds (Hutto, 2000; Sillett and Holmes, 2002; Newton, 2004

  5. CRITICAL RADIONUCLIDE AND PATHWAY ANALYSIS FOR THE SAVANNAH RIVER SITE

    SciTech Connect (OSTI)

    Jannik, T.

    2011-08-30T23:59:59.000Z

    This report is an update to the analysis, Assessment of SRS Radiological Liquid and Airborne Contaminants and Pathways, that was performed in 1997. An electronic version of this large original report is included in the attached CD to this report. During the operational history (1954 to the present) of the Savannah River Site (SRS), many different radionuclides have been released to the environment from the various production facilities. However, as will be shown by this updated radiological critical contaminant/critical pathway analysis, only a small number of the released radionuclides have been significant contributors to potential doses and risks to offsite people. The analysis covers radiological releases to the atmosphere and to surface waters, the principal media that carry contaminants offsite. These releases potentially result in exposure to offsite people. The groundwater monitoring performed at the site shows that an estimated 5 to 10% of SRS has been contaminated by radionuclides, no evidence exists from the extensive monitoring performed that groundwater contaminated with these constituents has migrated off the site (SRS 2011). Therefore, with the notable exception of radiological source terms originating from shallow surface water migration into site streams, onsite groundwater was not considered as a potential exposure pathway to offsite people. In addition, in response to the Department of Energy's (DOE) Order 435.1, several Performance Assessments (WSRC 2008; LWO 2009; SRR 2010; SRR 2011) and a Comprehensive SRS Composite Analysis (SRNO 2010) have recently been completed at SRS. The critical radionuclides and pathways identified in these extensive reports are discussed and, where applicable, included in this analysis.

  6. Impact of Concurrent Androgen Deprivation on Fiducial Marker Migration in External-beam Radiation Therapy for Prostate Cancer

    SciTech Connect (OSTI)

    Tiberi, David A.; Carrier, Jean-Francois; Beauchemin, Marie-Claude; Nguyen, Thu Van; Beliveau-Nadeau, Dominic [Departement de Radio-Oncologie, Centre hospitalier de l'Universite de Montreal-Hopital Notre-Dame, Montreal, Quebec (Canada)] [Departement de Radio-Oncologie, Centre hospitalier de l'Universite de Montreal-Hopital Notre-Dame, Montreal, Quebec (Canada); Taussky, Daniel, E-mail: daniel.taussky.chum@ssss.gouv.qc.ca [Departement de Radio-Oncologie, Centre hospitalier de l'Universite de Montreal-Hopital Notre-Dame, Montreal, Quebec (Canada)] [Departement de Radio-Oncologie, Centre hospitalier de l'Universite de Montreal-Hopital Notre-Dame, Montreal, Quebec (Canada)

    2012-09-01T23:59:59.000Z

    Purpose: To determine the extent of gold fiducial marker (FM) migration in patients treated for prostate cancer with concurrent androgen deprivation and external-beam radiation therapy (EBRT). Methods and Materials: Three or 4 gold FMs were implanted in 37 patients with prostate adenocarcinoma receiving androgen deprivation therapy (ADT) in conjunction with 70-78 Gy. Androgen deprivation therapy was started a median of 3.9 months before EBRT (range, 0.3-12.5 months). To establish the extent of FM migration, the distance between each FM was calculated for 5-8 treatments once per week throughout the EBRT course. For each treatment, the distance between FMs was compared with the distance from the digitally reconstructed radiographs generated from the planning CT. A total of 281 treatments were analyzed. Results: The average daily migration was 0.8 {+-} 0.3 mm, with distances ranging from 0.2 mm-2.6 mm. Two of the 281 assessed treatments (0.7%) showed migrations >2 mm. No correlation between FM migration and patient weight or time delay between ADT and start of EBRT was found. There was no correlation between the extent of FM migration and prostate volume. Conclusion: This is the largest report of implanted FM migration in patients receiving concomitant ADT. Only 0.7% of the 281 treatments studied had significant marker migrations (>2 mm) throughout the course of EBRT. Consequently, the use of implanted FMs in these patients enables accurate monitoring of prostate gland position during treatment.

  7. Pathway and Resource Overview

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn'tOrigin of Contamination in235-1 Termoelectrica U.SPRESSHeavy-dutyDepartmentPath to HighPathway

  8. Pathways for Algal Biofuels

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn'tOrigin of Contamination in235-1 Termoelectrica U.SPRESSHeavy-dutyDepartmentPath toPathways Toward

  9. 6-Phosphogluconate dehydrogenase regulates tumor cell migration in vitro by regulating receptor tyrosine kinase c-Met

    SciTech Connect (OSTI)

    Chan, Barden, E-mail: cchan@bidmc.harvard.edu [Division of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 (United States)] [Division of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 (United States); VanderLaan, Paul A. [Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 (United States)] [Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 (United States); Sukhatme, Vikas P. [Division of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 (United States)] [Division of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 (United States)

    2013-09-20T23:59:59.000Z

    Highlights: •Expression of 6PGD positively correlates with advancing stage of lung carcinoma. •Knockdown of 6PGD by shRNA potently inhibits c-Met tyrosine phosphorylation. •Exogenous HGF fails to restore c-Met phosphorylation in cells with 6PGD knocked down. •6PGD knockdown results in inhibition of cell migration in vitro. •Constitutively active TPR-cMet significantly restores migration of cells without 6PGD. -- Abstract: 6-Phosphogluconate dehydrogenase (6PGD) is the third enzyme in the oxidative pentose phosphate pathway (PPP). Recently, we reported that knockdown of 6PGD inhibited lung tumor growth in vitro and in a xenograft model in mice. In this study, we continued to examine the functional role of 6PGD in cancer. We show that 6PGD expression positively correlates with advancing stage of lung carcinoma. In search of functional signals related to 6PGD, we discovered that knockdown of 6PGD significantly inhibited phosphorylation of c-Met at tyrosine residues known to be critical for activity. This downregulation of c-Met phosphorylation correlated with inhibition of cell migration in vitro. Overexpression of a constitutively active c-Met specifically rescued the migration but not proliferation phenotype of 6PGD knockdown. Therefore, 6PGD appears to be required for efficient c-Met signaling and migration of tumor cells in vitro.

  10. Giant Planet Migration through the Action of Disk Torques and Planet Scattering

    E-Print Network [OSTI]

    Althea V. Moorhead; Fred C. Adams

    2005-05-11T23:59:59.000Z

    This paper presents a parametric study of giant planet migration through the combined action of disk torques and planet-planet scattering. The torques exerted on planets during Type II migration in circumstellar disks readily decrease the semi-major axes, whereas scattering between planets increases the orbital eccentricities. This paper presents a parametric exploration of the possible parameter space for this migration scenario using two (initial) planetary mass distributions and a range of values for the time scale of eccentricity damping (due to the disk). For each class of systems, many realizations of the simulations are performed in order to determine the distributions of the resulting orbital elements of the surviving planets; this paper presents the results of 8500 numerical experiments. Our goal is to study the physics of this particular migration mechanism and to test it against observations of extrasolar planets. The action of disk torques and planet-planet scattering results in a distribution of final orbital elements that fills the a-e plane, in rough agreement with the orbital elements of observed extrasolar planets. In addition to specifying the orbital elements, we characterize this migration mechanism by finding the percentages of ejected and accreted planets, the number of collisions, the dependence of outcomes on planetary masses, the time spent in 2:1 and 3:1 resonances, and the effects of the planetary IMF. We also determine the distribution of inclination angles of surviving planets and the distribution of ejection speeds for exiled planets.

  11. On the migration of two planets in a disc and the formation of mean motion resonances

    E-Print Network [OSTI]

    Migaszewski, Cezary

    2015-01-01T23:59:59.000Z

    We study the dynamics of a system of two super-Earths embedded in a protoplanetary disc. Depending on the disc parameters, planets' masses and positions in the disc, the migration of a planet can be inward or outward and the migration of a two-planet system can be convergent or divergent. The convergent migration means that the period ratio P2/P1 decreases in time. In such a case mean motion resonance (MMR) can be formed when the period ratio reaches a resonant value of a first order MMR (p+1)/p, where p is a small integer. When the divergent migration occurs, P2/P1 increases in time and a system initially close to MMR moves away from the resonance. We build a simple model of an irradiated viscous disc and use analytical prescriptions for the planet-disc interactions. We performed 3500 simulations of the migration of two-planet systems with various masses and initial orbits. We found that approximately half of the systems end up as configurations involved in one of the first order MMRs such as 2:1, 3:2, 4:3 a...

  12. OUT OF EGYPT: Globalisation, marginalisation and illegal Muslim migration to the EU

    E-Print Network [OSTI]

    Talani, Leila Simona

    2005-01-01T23:59:59.000Z

    marginalisation and illegal Muslim migration to the EU: Drbased in Cairo working on illegal migration from the Middleunderstand the problem of illegal migration in the context

  13. Syngas Upgrading to Hydrocarbon Fuels Technology Pathway

    SciTech Connect (OSTI)

    Talmadge, M.; Biddy, Mary J.; Dutta, Abhijit; Jones, Susanne B.; Meyer, Pimphan A.

    2013-03-31T23:59:59.000Z

    In support of the Bioenergy Technologies Office, the National Renewable Energy Laboratory (NREL) and the Pacific Northwest National Laboratory (PNNL) are undertaking studies of biomass conversion technologies to hydrocarbon fuels to identify barriers and target research toward reducing conversion costs. Process designs and preliminary economic estimates for each of these pathway cases were developed using rigorous modeling tools (Aspen Plus and Chemcad). These analyses incorporated the best information available at the time of development, including data from recent pilot and bench-scale demonstrations, collaborative industrial and academic partners, and published literature and patents. This pathway case investigates the upgrading of biomass derived synthesis gas (‘syngas’) to hydrocarbon biofuels. While this specific discussion focuses on the conversion of syngas via a methanol intermediate to hydrocarbon blendstocks, there are a number of alternative conversion routes for production of hydrocarbons through a wide array of intermediates from syngas. Future work will also consider the variations to this pathway to determine the most economically viable and risk adverse conversion route. Technical barriers and key research needs have been identified that should be pursued for the syngas to hydrocarbon pathway to be competitive with petroleum-derived gasoline, diesel and jet range blendstocks.

  14. Fuel Pathways Integration Tech Team

    Broader source: Energy.gov [DOE]

    Presentation on Fuel Pathways Integration Tech Team to the DOE Systems Analysis Workshop held in Washington, D.C. July 28-29, 2004.

  15. Dominant Pathways in Protein Folding

    E-Print Network [OSTI]

    P. Faccioli; M. Sega; F. Pederiva; H. Orland

    2006-07-27T23:59:59.000Z

    We present a method to investigate the kinetics of protein folding on a long time-scale and the dynamics underlying the formation of secondary and tertiary structures during the entire reaction. The approach is based on the formal analogy between thermal and quantum diffusion: by writing the solution of the Fokker-Planck equation for the time-evolution of a protein in a viscous heat-bath in terms of a path integral, we derive a Hamilton-Jacobi variational principle from which we are able to compute the most probable pathway of folding. The method is applied to the folding of the Villin Headpiece Subdomain, in the framework of a Go-model. We have found that, in this model, the transition occurs through an initial collapsing phase driven by the starting coil configuration and a later rearrangement phase, in which secondary structures are formed and all computed paths display strong similarities. This method is completely general, does not require the prior knowledge of any reaction coordinate and represents an efficient tool to perfom ab-initio simulations of the entire folding process with available computers.

  16. Multiphase fluid flow and time lapse seismics UNLP, 11 Octubre de ...

    E-Print Network [OSTI]

    santos

    Time-lapse seismic surveys aim to monitor the migration and dispersal of the CO2 plume after injection. Multiphase fluid flow and time lapse seismics – p. 3 ...

  17. Rural migration in the western states

    SciTech Connect (OSTI)

    Freiwald, J.G.; Poster, B.R.; Olinger, C.; Aragon, P.C.; Buslee, P.L.

    1980-05-01T23:59:59.000Z

    The rapid rural growth rate since 1970 in 14 western states (Arizona, Colorado, Kansas, Idaho, Montana, Nebraska, Nevada, New Mexico, North Dakota, Oklahoma, South Dakota, Texas, Utah, and Wyoming) was stimulated by recreation, resource development, manufacturing, commuting, institutional employment, and retirement. The eight Rocky Mountain States had significantly greater rural growth than the six Great Plains States. Other factors correlated with in-migration are population growth during the 1960's, presence of an interstate highway, adjacency to a metropolitan area, high per capita income, high population density, and absence of rural farm population. The presence of a central city with a population of over 20,000 or of a military base does not appear to be significantly related to net in-migration. An overview of regional growth patterns and of the factors related to rural in-migration is included, followed by an examination of these factors for each of the counties that experienced high in-migration in the 14 states.

  18. Anchored Mobilities: Mobile Technology and Transnational Migration

    E-Print Network [OSTI]

    Dourish,Paul

    Anchored Mobilities: Mobile Technology and Transnational Migration Amanda Williams Donald Bren Irvine, CA 92697-3440, USA jpd@ics.uci.edu ABSTRACT Mobile technologies are deployed into diverse social mobility. We present an ethnography of transnational Thai retirees and their uses of mobile technology

  19. Capillary migration of microdisks on curved interfaces

    E-Print Network [OSTI]

    Lu Yao; Nima Sharifi-Mood; Iris B. Liu; Kathleen J. Stebe

    2014-12-23T23:59:59.000Z

    The capillary energy landscape for particles on curved fluid interfaces is strongly influenced by the particle wetting conditions. Contact line pinning has now been widely reported for colloidal particles, but its implications in capillary interactions have not been addressed. Here, we present experiment and analysis for disks with pinned contact lines on curved fluid interfaces. In experiment, we study microdisk migration on a host interface with zero mean curvature; the microdisks have contact lines pinned at their sharp edges and are sufficiently small that gravitational effects are negligible. The disks migrate away from planar regions toward regions of steep curvature with capillary energies inferred from the dissipation along particle trajectories which are linear in the deviatoric curvature. We derive the curvature capillary energy for an interface with arbitrary curvature, and discuss each contribution to the expression. By adsorbing to a curved interface, a particle eliminates a patch of fluid interface and perturbs the surrounding interface shape. Analysis predicts that perfectly smooth, circular disks do not migrate, and that nanometric deviations from a planar circular, contact line, like those around a weakly roughened planar disk, will drive migration with linear dependence on deviatoric curvature, in agreement with experiment.

  20. Formation of Earth-like Planets During and After Giant Planet Migration

    E-Print Network [OSTI]

    Avi M. Mandell; Sean N. Raymond; Steinn Sigurdsson

    2007-01-02T23:59:59.000Z

    Close-in giant planets are thought to have formed in the cold outer regions of planetary systems and migrated inward, passing through the orbital parameter space occupied by the terrestrial planets in our own Solar System. We present dynamical simulations of the effects of a migrating giant planet on a disk of protoplanetary material and the subsequent evolution of the planetary system. We numerically investigate the dynamics of post-migration planetary systems over 200 million years using models with a single migrating giant planet, one migrating and one non-migrating giant planet, and excluding the effects of a gas disk. Material that is shepherded in front of the migrating giant planet by moving mean motion resonances accretes into "hot Earths", but survival of these bodies is strongly dependent on dynamical damping. Furthermore, a significant amount of material scattered outward by the giant planet survives in highly excited orbits; the orbits of these scattered bodies are then damped by gas drag and dynamical friction over the remaining accretion time. In all simulations Earth-mass planets accrete on approximately 100 Myr timescales, often with orbits in the Habitable Zone. These planets range in mass and water content, with both quantities increasing with the presence of a gas disk and decreasing with the presence of an outer giant planet. We use scaling arguments and previous results to derive a simple recipe that constrains which giant planet systems are able to form and harbor Earth-like planets in the Habitable Zone, demonstrating that roughly one third of the known planetary systems are potentially habitable.

  1. Study of Golden Eagles Migration in the Calgary Canada

    E-Print Network [OSTI]

    Liao, Tianqing

    2013-01-01T23:59:59.000Z

    Eagles Migration in the Calgary Canada A thesis submitted inMigration in the Calgary Canada by Tianqing Liao Master ofMountains of Calgary, Canada. The project began in March

  2. Channel Meander Migration in Large-Scale Physical Model Study 

    E-Print Network [OSTI]

    Yeh, Po Hung

    2010-10-12T23:59:59.000Z

    A set of large-scale laboratory experiments were conducted to study channel meander migration. Factors affecting the migration of banklines, including the ratio of curvature to channel width, bend angle, and the Froude ...

  3. Deadlock-free fine-grained thread migration

    E-Print Network [OSTI]

    Cho, Myong Hyon

    Several recent studies have proposed fine-grained, hardware-level thread migration in multicores as a solution to power, reliability, and memory coherence problems. The need for fast thread migration has been well documented, ...

  4. Structural Dynamics of Various Causes of Migration in Jaipur

    E-Print Network [OSTI]

    Jayant Singh; Hansraj Yadav; Florentin Smarandache

    2008-04-06T23:59:59.000Z

    Various social causes for migration in Jaipur are studied and statistical hypotheses are made in this paper.

  5. A methodology to assess the radionuclide migration parameters through bentonite-sand backfill in a short experimental duration

    SciTech Connect (OSTI)

    Gurumoorthy, C.; Kusakabe, O. [Tokyo Institute of Technology, Geotechnical Engineering Div., Dept. of Civil and Environmental Engineering, Tokyo (Japan)

    2007-07-01T23:59:59.000Z

    Bentonite-Sand Backfill is a part of Engineered Barrier System (EBS) widely used in a Near Surface Disposal Facility (NSDF) to delay migration of radionuclides from the disposed nuclear waste in a geo environment. Laboratory migration experiments have been conducted to understand the advection/diffusion mechanisms of various radionuclides through backfill and to evaluate their migration rates in order to assess the performance of EBS. Migration through backfill is an extremely slow process and the experiments are time consuming. Also, these experiments have limitations to simulate the field stress conditions. Various researchers have experienced the advantages of centrifuge modeling technique to model contaminant transport problems of geo-environment. However, no such studies have been carried out adopting this technique to model the behaviour of bentonite-sand mixture as backfill in NSDF. An attempt has been made in the present study to investigate the validity of this technique to carry out such studies. Significance of geotechnical centrifuge modeling to simulate the prototype radionuclide migration mechanisms through backfill is highlighted. This paper presents the dimensional analysis of various scale factors to construct a physical model for centrifuge tests to monitor online the migration phenomena of radionuclides through bentonite-sand mixture. Studies reveal the feasibility of the technique to evaluate the migration parameters in a short experimental duration. Such studies help in improving EBS design and assessing the long-term performance of EBS in NSDF. (authors)

  6. A novel molecular index for secondary oil migration distance

    E-Print Network [OSTI]

    Wang, Yang

    migration distances from source rocks to reservoirs can greatly help in the search for new petroleum and correlates solely with migration distance from source rock to reservoir. Case studies serve to demonstrate alteration of buried organic matter in source rocks, followed by oil expulsion (primary migration) out

  7. Simulation of salt migrations in density dependent groundwater flow

    E-Print Network [OSTI]

    Vuik, Kees

    Simulation of salt migrations in density dependent groundwater flow E.S. van Baaren Master's Thesis for the salt migration in the groundwater underneath the polders near the coast. The problem description of this thesis is to investigate the possibilities of modelling salt migrations in density dependent groundwater

  8. Whole Algae Hydrothermal Liquefaction Technology Pathway

    SciTech Connect (OSTI)

    Biddy, Mary J.; Davis, Ryan; Jones, Susanne B.; Zhu, Yunhua

    2013-03-31T23:59:59.000Z

    In support of the Bioenergy Technologies Office, the National Renewable Energy Laboratory (NREL) and the Pacific Northwest National Laboratory (PNNL) are undertaking studies of biomass conversion technologies to hydrocarbon fuels to identify barriers and target research toward reducing conversion costs. Process designs and preliminary economic estimates for each of these pathway cases were developed using rigorous modeling tools (Aspen Plus and Chemcad). These analyses incorporated the best information available at the time of development, including data from recent pilot and bench-scale demonstrations, collaborative industrial and academic partners, and published literature and patents. This pathway case investigates the feasibility of using whole wet microalgae as a feedstock for conversion via hydrothermal liquefaction. Technical barriers and key research needs have been assessed in order for the hydrothermal liquefaction of microalgae to be competitive with petroleum-derived gasoline, diesel and jet range blendstocks.

  9. arginine-dimethylarginine dimethylaminohydrolase pathway: Topics...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    below CS111. Website: http:www.cs.bu.edu; Contact: Wayne Snyder, snyder Goldberg, Bennett 10 Biological Pathways A pathway to explore diseases mechanism Biology and Medicine...

  10. Directional Sensing Orients Cell Migration and Polarization

    E-Print Network [OSTI]

    Devreotes, Peter

    and interactions between the cells of our nervous system during development (9). Later in life, cell movements downstream pathways. In Dictyostelium, chemotaxis plays a critical role in all stages of its life cycle of the cell cortex (10, 46, 49, 55). In neutrophils and highly developed Dictyostelium cells, the efficiency

  11. Angiogenic activity of sesamin through the activation of multiple signal pathways

    SciTech Connect (OSTI)

    Chung, Byung-Hee [Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon (Korea, Republic of) [Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon (Korea, Republic of); Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon (Korea, Republic of); Lee, Jung Joon [Center for Molecular Cancer Research, Korea Research Institute of Bioscience and Biotechnology, Daejeon (Korea, Republic of)] [Center for Molecular Cancer Research, Korea Research Institute of Bioscience and Biotechnology, Daejeon (Korea, Republic of); Kim, Jong-Dai [Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon (Korea, Republic of)] [Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon (Korea, Republic of); Jeoung, Dooil; Lee, Hansoo [Division of Life Sciences, Kangwon National University, Chuncheon (Korea, Republic of)] [Division of Life Sciences, Kangwon National University, Chuncheon (Korea, Republic of); Choe, Jongseon; Ha, Kwon-Soo [Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon (Korea, Republic of)] [Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon (Korea, Republic of); Kwon, Young-Geun [Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul (Korea, Republic of)] [Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul (Korea, Republic of); Kim, Young-Myeong, E-mail: ymkim@kangwon.ac.kr [Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon (Korea, Republic of)] [Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon (Korea, Republic of)

    2010-01-01T23:59:59.000Z

    The natural product sesamin has been known to act as a potent antioxidant and prevent endothelial dysfunction. We here found that sesamin increased in vitro angiogenic processes, such as endothelial cell proliferation, migration, and tube formation, as well as neovascularization in an animal model. This compound elicited the activation of multiple angiogenic signal modulators, such as ERK, Akt, endothelial nitric oxide synthase (eNOS), NO production, FAK, and p38 MAPK, but not Src. The MEK inhibitor PD98059 and the PI3K inhibitor Wortmannin specifically inhibited sesamin-induced activation of the ERK and Akt/eNOS pathways. These inhibitors reduced angiogenic events, with high specificity for MEK/ERK-dependent cell proliferation and migration and PI3K/Akt-mediated tube formation. Moreover, inhibition of p38 MAPK effectively inhibited sesamin-induced cell migration. The angiogenic activity of sesamin was not associated with VEGF expression. Furthermore, this compound did not induce vascular permeability and upregulated ICAM-1 and VCAM-1 expression, which are hallmarks of vascular inflammation. These results suggest that sesamin stimulates angiogenesis in vitro and in vivo through the activation of MEK/ERK-, PI3K/Akt/eNOS-, p125{sup FAK}-, and p38 MAPK-dependent pathways, without increasing vascular inflammation, and may be used for treating ischemic diseases and tissue regeneration.

  12. Groundwater migration of radionuclides at Fermilab

    SciTech Connect (OSTI)

    Malensek, A.J.; Wehmann, A.A.; Elwyn, A.J.; Moss, K.J.; Kesich, P.M.

    1993-09-20T23:59:59.000Z

    The simple Single Resident Well (SRW) Model has been used to calculate groundwater movement since Fermilab`s inception. A new Concentration Model is proposed which is more realistic and takes advantage of computer modeling that has been developed for the siting of landfills. Site geologic and hydrologic data were given to a consultant who made the migration calculations from an initial concentration that was based upon the existing knowledge of the radioactivity leached out of the soil. The various components of the new Model are discussed, and numerical examples are given and compared with DOE/EPA limits.

  13. Planet Migration and Disk Destruction due to Magneto-Centrifugal Stellar Winds

    E-Print Network [OSTI]

    R. V. E. Lovelace; M. M. Romanova; A. W. Barnard

    2008-06-25T23:59:59.000Z

    This paper investigates the influence of magneto-centrifugally driven or simply magnetic winds of rapidly-rotating, strongly-magnetized T Tauri stars in causing the inward or outward migration of close-in giant planets. The azimuthal ram pressure of the magnetized wind acting on the planet tends to increase the planet's angular momentum and cause outward migration if the star's rotation period $P_*$ is less than the planet's orbital period $P_p$. In the opposite case, $P_* > P_p$, the planet migrates inward. Thus, planets orbiting at distances larger (smaller) than $0.06 {\\rm AU}(P_*/5{\\rm d})^{2/3}$ tend to be pushed outward (inward), where $P_*$ is the rotation period of the star assumed to have the mass of the sun. The magnetic winds are likely to occur in T Tauri stars where the thermal speed of the gas close to the star is small, where the star's magnetic field is strong, and where the star rotates rapidly. The time-scale for appreciable radial motion of the planet is estimated as $\\sim 2 - 20$ Myr. A sufficiently massive close-in planet may cause tidal locking and once this happens the radial migration due to the magnetic wind ceases. The magnetic winds are expected to be important for planet migration for the case of a multipolar magnetic field rather than a dipole field where the wind is directed away from the equatorial plane and where a magnetospheric cavity forms. The influence of the magnetic wind in eroding and eventually destroying the accretion disk is analyzed. A momentum integral is derived for the turbulent wind/disk boundary layer and this is used to estimate the disk erosion time-scale as $\\sim 1-10^2$ Myr, with the lower value favored.

  14. Abstract In migrating birds, the success of migration is determined by stopover duration, the most important

    E-Print Network [OSTI]

    Richner, Heinz

    warblers Sylvia borin at 17 stopover sites in Europe and Africa during autumn. Average stopover duration regulate stopover duration. Keywords Stopover length · Migration strategy · Passerine birds · Capture and the wintering grounds into phases of flights and stop- overs. At good stopover sites, energy reserves are replen

  15. The Built Environment and Migration: A Case Study of Mexico

    E-Print Network [OSTI]

    Ramirez, Rosa

    2009-01-01T23:59:59.000Z

    and Community Networks in Mexico-U.S. Migration. THe JournalTraditional Architecture of Mexico. London, UK: Thames anddevelopment: assessing Mexico's economic and social policy

  16. Catalog of Waters Important for the Spawning, Rearing or Migration...

    Open Energy Info (EERE)

    Spawning, Rearing or Migration of Anadromous Fishes Organization Alaska Department of Fish and Game Published Divisions of Sport Fish and Habitat, 2012 Report Number 12-05 DOI...

  17. Coupled Flow and Deformation Modeling of Carbon Dioxide Migration in the Presence of a Caprock Fracture during Injection

    SciTech Connect (OSTI)

    Siriwardane, Hema J.; Gondle, Raj K.; Bromhal, Grant S.

    2013-08-01T23:59:59.000Z

    Understanding the transport of carbon dioxide (CO{sub 2}) during long-term CO{sub 2} injection into a typical geologic reservoir, such as a saline aquifer, could be complicated because of changes in geochemical, hydrogeological, and hydromechanical behavior. While the caprock layer overlying the target aquifer is intended to provide a tight, impermeable seal in securing injected CO{sub 2}, the presence of geologic uncertainties, such as a caprock fracture or fault, may provide a channel for CO{sub 2} leakage. There could also be a possibility of the activation of a new or existing dormant fault or fracture, which could act as a leakage pathway. Such a leakage event during CO{sub 2} injection may lead to a different pressure and ground response over a period of time. In the present study, multiphase fluid flow simulations in porous media coupled with geomechanics were used to investigate the overburden geologic response and plume behavior during CO{sub 2} injection in the presence of a hypothetical permeable fractured zone in a caprock, existing or activated. Both single-phase and multiphase fluid flow simulations were performed. The CO{sub 2} migration through an existing fractured zone leads to changes in the fluid pressure in the overburden geologic layers and could have a significant impact on ground deformation behavior. Results of the study show that pressure signatures and displacement patterns are significantly different in the presence of a fractured zone in the caprock layer. The variation in pressure and displacement signatures because of the presence of a fractured zone in the caprock at different locations may be useful in identifying the presence of a fault/fractured zone in the caprock. The pressure signatures can also serve as a mechanism to identify the activation of leakage pathways through the caprock during CO{sub 2} injection. Pressure response and ground deformation behavior from sequestration modeling could be useful in the development of smart technologies to monitor safe CO{sub 2} storage and understand CO{sub 2} transport, with limited field instrumentation.

  18. Concrete Property and Radionuclide Migration Tests

    SciTech Connect (OSTI)

    Wellman, Dawn M.; Mattigod, Shas V.; Powers, Laura; Parker, Kent E.; Clayton, Libby N.; Wood, Marcus I.

    2008-10-01T23:59:59.000Z

    The Waste Management Project provides safe, compliant, and cost-effective waste management services for the Hanford Site and the DOE Complex. Part of theses services includes safe disposal of LLW and MLLW at the Hanford Low-Level Waste Burial Grounds (LLBG) in accordance with the requirements listed in DOE Order 435.1, Radioactive Waste Management. To partially satisfy these requirements, a Performance Assessment (PA) analyses were completed and approved. DOE Order 435.1 also requires that continuing data collection be conducted to enhance confidence in the critical assumptions used in these analyses to characterize the operational features of the disposal facility that are relied upon to satisfy the performance objectives identified in the Order. One critical assumption is that concrete will frequently be used as waste form or container material to control and minimize the release of radionuclide constituents in waste into the surrounding environment. Data was collected to (1) quantify radionuclide migration through concrete materials similar to those used to encapsulate waste in the LLBG, (2) measure the properties of the concrete materials, especially those likely to influence radionuclide migration, and (3) quantify the stability of U-bearing solid phases of limited solubility in concrete.

  19. Pathways Analysis for State Proliferators 

    E-Print Network [OSTI]

    Mella, Michael

    2012-07-16T23:59:59.000Z

    for Sweden .......................................................... 89 Figure 29 The enrichment pathways for Sweden .................................................... 90 Figure 30 Loose export controls but no reactor, reprocessing, or enrichment... for Saudi Arabia ............................................................... 94 Figure 31 Loose export controls and a reactor for Saudi Arabia. ............................ 95 Figure 32 Loose export controls with a reactor and reprocessing...

  20. Environmental Analysis & Policy: Sample Pathway

    E-Print Network [OSTI]

    Goldberg, Bennett

    Environmental Analysis & Policy: Sample Pathway Semester I Semester II Freshman Year CGS Core CGS Sustainable Development OR Spring GE 425 U.S. Environmental Policy (Senior) GE 309 Intermediate Env Analysis (Fall) EAP Elective Summer Environmental Internship Senior Year GE 420 Env Policy Analysis 4 th Semester

  1. Transportation Energy Pathways LDRD.

    SciTech Connect (OSTI)

    Barter, Garrett; Reichmuth, David; Westbrook, Jessica; Malczynski, Leonard A. [Sandia National Laboratories, Albuquerque, NM; Yoshimura, Ann S.; Peterson, Meghan; West, Todd H.; Manley, Dawn Kataoka; Guzman, Katherine Dunphy; Edwards, Donna M.; Hines, Valerie Ann-Peters

    2012-09-01T23:59:59.000Z

    This report presents a system dynamics based model of the supply-demand interactions between the USlight-duty vehicle (LDV) fleet, its fuels, and the corresponding primary energy sources through the year2050. An important capability of our model is the ability to conduct parametric analyses. Others have reliedupon scenario-based analysis, where one discrete set of values is assigned to the input variables and used togenerate one possible realization of the future. While these scenarios can be illustrative of dominant trendsand tradeoffs under certain circumstances, changes in input values or assumptions can have a significantimpact on results, especially when output metrics are associated with projections far into the future. Thistype of uncertainty can be addressed by using a parametric study to examine a range of values for the inputvariables, offering a richer source of data to an analyst.The parametric analysis featured here focuses on a trade space exploration, with emphasis on factors thatinfluence the adoption rates of electric vehicles (EVs), the reduction of GHG emissions, and the reduction ofpetroleum consumption within the US LDV fleet. The underlying model emphasizes competition between13 different types of powertrains, including conventional internal combustion engine (ICE) vehicles, flex-fuel vehicles (FFVs), conventional hybrids(HEVs), plug-in hybrids (PHEVs), and battery electric vehicles(BEVs).We find that many factors contribute to the adoption rates of EVs. These include the pace of technologicaldevelopment for the electric powertrain, battery performance, as well as the efficiency improvements inconventional vehicles. Policy initiatives can also have a dramatic impact on the degree of EV adoption. Theconsumer effective payback period, in particular, can significantly increase the market penetration rates ifextended towards the vehicle lifetime.Widespread EV adoption can have noticeable impact on petroleum consumption and greenhouse gas(GHG) emission by the LDV fleet. However, EVs alone cannot drive compliance with the most aggressiveGHG emission reduction targets, even as the current electricity source mix shifts away from coal and towardsnatural gas. Since ICEs will comprise the majority of the LDV fleet for up to forty years, conventional vehicleefficiency improvements have the greatest potential for reductions in LDV GHG emissions over this time.These findings seem robust even if global oil prices rise to two to three times current projections. Thus,investment in improving the internal combustion engine might be the cheapest, lowest risk avenue towardsmeeting ambitious GHG emission and petroleum consumption reduction targets out to 2050.3 AcknowledgmentThe authors would like to thank Dr. Andrew Lutz, Dr. Benjamin Wu, Prof. Joan Ogden and Dr. ChristopherYang for their suggestions over the course of this project. This work was funded by the Laboratory DirectedResearch and Development program at Sandia National Laboratories.4

  2. Towards a Framework for Migrating Web Applications to Web Services

    E-Print Network [OSTI]

    Cordy, James R.

    Towards a Framework for Migrating Web Applications to Web Services Asil A. Almonaies Manar H {asil,alalfi,cordy,dean}@cs.queensu.ca Abstract Migrating traditional legacy web applications to web services is an important step in the modernization of web-based business systems to more complex inter

  3. Department of Economic and Social Affairs International Migration Report 2002

    E-Print Network [OSTI]

    Huang, Youqin

    Department of Economic and Social Affairs International Migration Report 2002 United Nations #12;ST/ESA/SER.A/220 Department of Economic and Social Affairs Population Division International Migration Report 2002 rights reserved #12;iii PREFACE The Population Division of the Department of Economic and Social Affairs

  4. MOVARTO: Server Migration across Networks using Route Triangulation and DNS

    E-Print Network [OSTI]

    Sundaram, Ravi

    MOVARTO: Server Migration across Networks using Route Triangulation and DNS Problem: How do I move a server across the Internet? Server migration across wide area networks is a fundamental issue faced applications are hosted on servers at remote data centers and accessed via the Internet. These applications

  5. A Framework for Migrating Web Applications to Web Services

    E-Print Network [OSTI]

    Cordy, James R.

    A Framework for Migrating Web Applications to Web Services Asil A. Almonaies, Manar H. Alalfi-automatically migrat- ing monolithic legacy web applications to service oriented architecture (SOA) by separating potentially reusable features as web services. Software design re- covery and source transformation techniques

  6. CANADA-SOUTHERN AFRICA MIGRATION SURVEY INFORMATION What is SAMP?

    E-Print Network [OSTI]

    Abolmaesumi, Purang

    1 CANADA-SOUTHERN AFRICA MIGRATION SURVEY INFORMATION What is SAMP? SAMP is the Southern African people in Canada and in Africa? SAMP recently launched a new migration project, The Diaspora Project come to Canada and do they ever think of going back? What kind of education individuals have obtained

  7. NEUTROPHILS INFLUENCE MELANOMA ADHESION AND MIGRATION UNDER FLOW CONDITIONS

    E-Print Network [OSTI]

    Dong, Cheng

    NEUTROPHILS INFLUENCE MELANOMA ADHESION AND MIGRATION UNDER FLOW CONDITIONS Margaret J. SLATTERY State University, University Park, PA, USA We have studied human melanoma cell (C8161) adhesion to be very low on these melanoma cells. As a result, C8161 trans- endothelial migration under a flow

  8. R326 Dispatch Nuclear migration: Cortical anchors for cytoplasmic dynein

    E-Print Network [OSTI]

    dynein, and provide a critical link in understanding the basis of nuclear migration in yeast. The nuclearR326 Dispatch Nuclear migration: Cortical anchors for cytoplasmic dynein Kerry Bloom Nuclear body that rolls around at random inside the sack of a eukaryotic cell. Controlled nuclear movements

  9. Migrating a Domain-Specific Modeling Infrastructure to MDA Technology

    E-Print Network [OSTI]

    van Deursen, Arie

    Migrating a Domain-Specific Modeling Infrastructure to MDA Technology Duncan Doyle1,2, Hans Geers2 be migrated to models conform the MDA, in order to benefit from the range of MDA standards. We describe of the lessons learned. 1 Introduction The MDA promise of model-driven development is becoming a reality

  10. Migration, rural development, poverty and food security: a comparative perspective

    E-Print Network [OSTI]

    Boyer, Edmond

    1 Migration, rural development, poverty and food security: a comparative perspective Thomas Lacroix rural underdevelopment, poverty and food insecurity in rural areas? The case studies provide mixed poverty, even for non-migrant households. In the countries benefiting from temporary migration schemes

  11. Characterization of Protein Folding by Dominant Reaction Pathways

    E-Print Network [OSTI]

    Pietro Faccioli

    2008-06-23T23:59:59.000Z

    We assess the reliability of the recently developed approach denominated Dominant Reaction Pathways (DRP) by studying the folding of a 16-residue beta-hairpin, within a coarse-grained Go-type model. We show that the DRP predictions are in quantitative agreement with the results of Molecular Dynamics simulations, performed in the same model. On the other hand, in the DRP approach, the computational difficulties associated to the decoupling of time scales are rigorously bypassed. The analysis of the important transition pathways supports a picture of the beta-hairpin folding in which the reaction is initiated by the collapse of the hydrophobic cluster.

  12. Atomic Computer Simulations of Defect Migration in 3C and 4H...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Computer Simulations of Defect Migration in 3C and 4H-SiC. Atomic Computer Simulations of Defect Migration in 3C and 4H-SiC. Abstract: Knowledge of the migration of intrinsic point...

  13. Degradation of Ionic Pathway in PEM Fuel Cell Cathode. | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Degradation of Ionic Pathway in PEM Fuel Cell Cathode. Degradation of Ionic Pathway in PEM Fuel Cell Cathode. Abstract: The degradation of the ionic pathway throughout the catalyst...

  14. Monitoring the Migrations of Wild Snake River Spring/Summer Chinook Salmon Smolts, 2001-2002 Annual Report.

    SciTech Connect (OSTI)

    Achond, Stephen; Hockersmith, Eric E.; Sandford, Benjamin P. (National Marine Fisheries Service, Northwest Fisheries Science Center, Seattle, WA)

    2003-07-01T23:59:59.000Z

    This report details the 2002 results from an ongoing project to monitor the migration behavior of wild spring/summer chinook salmon smolts in the Snake River Basin. The report also discusses trends in the cumulative data collected for this project from Oregon and Idaho streams since 1989. The project was initiated after detection data from passive-integrated-transponder tags (PIT tags) had shown distinct differences in migration patterns between wild and hatchery fish for three consecutive years. National Marine Fisheries Service (NMFS) investigators first observed these differences in 1989. The data originated from tagging and interrogation operations begun in 1988 to evaluate smolt transportation for the U.S. Army Corps of Engineers. In 1991, the Bonneville Power Administration began a cooperative effort with NMFS to expand tagging and interrogation of wild fish. Project goals were to characterize the outmigration timing of these fish, to determine whether consistent migration patterns would emerge, and to investigate the influence of environmental factors on the timing and distribution of these migrations. In 1992, the Oregon Department of Fish and Wildlife (ODFW) began an independent program of PIT tagging wild chinook salmon parr in the Grande Ronde and Imnaha River Basins in northeast Oregon. Since then, ODFW has reported all tagging, detection, and timing information on fish from these streams. However, with ODFW concurrence, NMFS will continue to report arrival timing of these fish at Lower Granite Dam.

  15. INFLUENCE OF ROCKY REACH DAM AND THE TEMPERATURE OF THE OKANOGAN RIVER ON THE UPSTREAM MIGRATION OF SOCKEYE

    E-Print Network [OSTI]

    INFLUENCE OF ROCKY REACH DAM AND THE TEMPERATURE OF THE OKANOGAN RIVER ON THE UPSTREAM MIGRATION Reach Dam, constructed on the Columbia River 7 miles above Wenatchee, Wash.· in 1957-61, has not appreciably increased the time required for adult sockeye salmon (Oncorhynchus nerka) to mi~rate to Zosel Dam

  16. Colonization, clear-cutting, and cornfields: Rural migration and deforestation in The Sierra de Lacandn National Park, Petn, Guatemala

    E-Print Network [OSTI]

    Lopez-Carr, David

    1 Colonization, clear-cutting, and cornfields: Rural migration and deforestation in The Sierra de variability in the amount of forest cleared in the sample. While the high deforestation group cleared an average of 13.6 hectares, or 49% of their forest during the time period, the low deforestation group

  17. In-Situ Catalytic Fast Pyrolysis Technology Pathway

    SciTech Connect (OSTI)

    Biddy, Mary J.; Dutta, Abhijit; Jones, Susanne B.; Meyer, Pimphan A.

    2013-03-31T23:59:59.000Z

    In support of the Bioenergy Technologies Office, the National Renewable Energy Laboratory (NREL) and the Pacific Northwest National Laboratory (PNNL) are undertaking studies of biomass conversion technologies to hydrocarbon fuels to identify barriers and target research toward reducing conversion costs. Process designs and preliminary economic estimates for each of these pathway cases were developed using rigorous modeling tools (Aspen Plus and Chemcad). These analyses incorporated the best information available at the time of development, including data from recent pilot and bench-scale demonstrations, collaborative industrial and academic partners, and published literature and patents. This pathway case investigates converting woody biomass using in-situ catalytic fast pyrolysis followed by upgrading to gasoline, diesel, and jet range blendstocks. Technical barriers and key research needs that should be pursued for this pathway to be competitive with petroleum-derived blendstocks have been identified.

  18. Ex-Situ Catalytic Fast Pyrolysis Technology Pathway

    SciTech Connect (OSTI)

    Biddy, Mary J.; Dutta, Abhijit; Jones, Susanne B.; Meyer, Pimphan A.

    2013-03-31T23:59:59.000Z

    In support of the Bioenergy Technologies Office, the National Renewable Energy Laboratory (NREL) and the Pacific Northwest National Laboratory (PNNL) are undertaking studies of biomass conversion technologies to hydrocarbon fuels to identify barriers and target research toward reducing conversion costs. Process designs and preliminary economic estimates for each of these pathway cases were developed using rigorous modeling tools (Aspen Plus and Chemcad). These analyses incorporated the best information available at the time of development, including data from recent pilot and bench-scale demonstrations, collaborative industrial and academic partners, and published literature and patents. This pathway case investigates converting woody biomass using ex-situ catalytic fast pyrolysis followed by upgrading to gasoline , diesel and jet range blendstocks . Technical barriers and key research needs that should be pursued for this pathway to be competitive with petroleum-derived blendstocks have been identified.

  19. Biological Conversion of Sugars to Hydrocarbons Technology Pathway

    SciTech Connect (OSTI)

    Davis, Ryan; Biddy, Mary J.; Tan, Eric; Tao, Ling; Jones, Susanne B.

    2013-03-31T23:59:59.000Z

    In support of the Bioenergy Technologies Office, the National Renewable Energy Laboratory (NREL) and the Pacific Northwest National Laboratory (PNNL) are undertaking studies of biomass conversion technologies to identify barriers and target research toward reducing conversion costs. Process designs and preliminary economic estimates for each of these pathway cases were developed using rigorous modeling tools (Aspen Plus and Chemcad). These analyses incorporated the best information available at the time of development, including data from recent pilot and bench-scale demonstrations, collaborative industrial and academic partners, and published literature and patents. This technology pathway case investigates the biological conversion of biomass derived sugars to hydrocarbon biofuels, utilizing data from recent literature references and information consistent with recent pilot scale demonstrations at NREL. Technical barriers and key research needs have been identified that should be pursued for the pathway to become competitive with petroleum-derived gasoline, diesel and jet range hydrocarbon blendstocks.

  20. Algal Lipid Extraction and Upgrading to Hydrocarbons Technology Pathway

    SciTech Connect (OSTI)

    Davis, Ryan; Biddy, Mary J.; Jones, Susanne B.

    2013-03-31T23:59:59.000Z

    In support of the Bioenergy Technologies Office, the National Renewable Energy Laboratory (NREL) and the Pacific Northwest National Laboratory (PNNL) are undertaking studies of biomass conversion technologies to identify barriers and target research toward reducing conversion costs. Process designs and preliminary economic estimates for each of these pathway cases were developed using rigorous modeling tools (Aspen Plus and Chemcad). These analyses incorporated the best information available at the time of development, including data from recent pilot and bench-scale demonstrations, collaborative industrial and academic partners, and published literature and patents. This technology pathway case investigates the cultivation of algal biomass followed by further lipid extraction and upgrading to hydrocarbon biofuels. Technical barriers and key research needs have been assessed in order for the algal lipid extraction and upgrading pathway to be competitive with petroleum-derived gasoline, diesel and jet range hydrocarbon blendstocks.

  1. Catalytic Upgrading of Sugars to Hydrocarbons Technology Pathway

    SciTech Connect (OSTI)

    Biddy, Mary J.; Jones, Susanne B.

    2013-03-31T23:59:59.000Z

    In support of the Bioenergy Technologies Office, the National Renewable Energy Laboratory (NREL) and the Pacific Northwest National Laboratory (PNNL) are undertaking studies of biomass conversion technologies to hydrocarbon fuels to identify barriers and target research toward reducing conversion costs. Process designs and preliminary economic estimates for each of these pathway cases were developed using rigorous modeling tools (Aspen Plus and Chemcad). These analyses incorporated the best information available at the time of development, including data from recent pilot and bench-scale demonstrations, collaborative industrial and academic partners, and published literature and patents. This technology pathway case investigates the catalytic conversion of solubilized carbohydrate streams to hydrocarbon biofuels, utilizing data from recent efforts within the National Advanced Biofuels Consortium (NABC) in collaboration with Virent, Inc.. Technical barriers and key research needs that should be pursued for the catalytic conversion of sugars pathway to be competitive with petroleum-derived gasoline, diesel and jet range hydrocarbon blendstocks have been identified.

  2. The Spectroscopic-Assisted Investigation into Energy Migration through Disordered Systems

    E-Print Network [OSTI]

    Colby, Kathryn Anne

    2012-01-01T23:59:59.000Z

    Photovoltaics and Energy Migration through Disordered Systems………………………………………………………………………Photovoltaics and Energy Migration through Disordered Systemsphotovoltaics. The study of energy flow through disordered systems

  3. Orbital Evolution and Migration of Giant Planets: Modeling Extrasolar Planets

    E-Print Network [OSTI]

    D. E. Trilling; W. Benz; T. Guillot; J. I. Lunine; W. B. Hubbard; A. Burrows

    1998-01-28T23:59:59.000Z

    Giant planets in circumstellar disks can migrate inward from their initial (formation) positions. Radial migration is caused by inward torques between the planet and the disk; by outward torques between the planet and the spinning star; and by outward torques due to Roche lobe overflow and consequent mass loss from the planet. We present self-consistent numerical considerations of the problem of migrating giant planets. Summing torques on planets for various physical parameters, we find that Jupiter-mass planets can stably arrive and survive at small heliocentric distances, thus reproducing observed properties of some of the recently discovered extra-solar planets. Inward migration timescales can be approximately equal to or less than disk lifetimes and star spindown timescales. Therefore, the range of fates of massive planets is broad, and generally comprises three classes: (I) planets which migrate inward too rapidly and lose all their mass; (II) planets which migrate inward, lose some but not all of their mass, and survive in very small orbits; and (III) planets which do not lose any mass. Some planets in Class III do not migrate very far from their formation locations. Our results show that there is a wide range of possible fates for Jupiter-mass planets for both final heliocentric distance and final mass.

  4. Control of charge migration in molecules by ultrashort laser pulses

    E-Print Network [OSTI]

    Nikolay V. Golubev; Alexander I. Kuleff

    2015-02-19T23:59:59.000Z

    Due to electronic many-body effects, the ionization of a molecule can trigger ultrafast electron dynamics appearing as a migration of the created hole charge throughout the system. Here we propose a scheme for control of the charge migration dynamics with a single ultrashort laser pulse. We demonstrate by fully ab initio calculations on a molecule containing a chromophore and an amine moieties that simple pulses can be used for stopping the charge-migration oscillations and localizing the charge on the desired site of the system. We argue that this control may be used to predetermine the follow-up nuclear rearrangement and thus the molecular reactivity.

  5. Control of charge migration in molecules by ultrashort laser pulses

    E-Print Network [OSTI]

    Golubev, Nikolay V

    2015-01-01T23:59:59.000Z

    Due to electronic many-body effects, the ionization of a molecule can trigger ultrafast electron dynamics appearing as a migration of the created hole charge throughout the system. Here we propose a scheme for control of the charge migration dynamics with a single ultrashort laser pulse. We demonstrate by fully ab initio calculations on a molecule containing a chromophore and an amine moieties that simple pulses can be used for stopping the charge-migration oscillations and localizing the charge on the desired site of the system. We argue that this control may be used to predetermine the follow-up nuclear rearrangement and thus the molecular reactivity.

  6. Exotic Earths: Forming Habitable Worlds with Giant Planet Migration

    E-Print Network [OSTI]

    Sean N. Raymond; Avi M. Mandell; Steinn Sigurdsson

    2006-09-08T23:59:59.000Z

    Close-in giant planets (e.g. ``Hot Jupiters'') are thought to form far from their host stars and migrate inward, through the terrestrial planet zone, via torques with a massive gaseous disk. Here we simulate terrestrial planet growth during and after giant planet migration. Several-Earth mass planets also form interior to the migrating Jovian planet, analogous to recently-discovered ``Hot Earths''. Very water-rich, Earth-mass planets form from surviving material outside the giant planet's orbit, often in the Habitable Zone and with low orbital eccentricities. More than a third of the known systems of giant planets may harbor Earth-like planets.

  7. Rapid Characterization of Cellular Pathways Using Time-Varying Signals

    E-Print Network [OSTI]

    Thomson, Ty M

    2005-10-21T23:59:59.000Z

    The use of traditional tools for the discovery and characterization of biological systems has resulted in a wealth of biological knowledge. Unfortunately, only a small portion of the biological world is well-understood ...

  8. Analysis of Signalling Pathways using Continuous Time Markov Chains

    E-Print Network [OSTI]

    Calder, M.

    Calder,M. Vyshemirsky,V. Gilbert,D. Orton,R. Trans.on Computat. Syst. Biol. VI, volume 4220 pp 44-67 Springer Verlag

  9. Mechanisms of contaminant migration from grouted waste

    SciTech Connect (OSTI)

    Magnuson, S.O. [EG and G Idaho, Inc., Idaho Falls, ID (United States); Yu, A.D. [Westinghouse Savannah River Co., Aiken, SC (United States)

    1992-12-31T23:59:59.000Z

    Low-level radioactive decontaminated salt solution is generated at the Savannah River Site (SRS) from the In-Tank Precipitation process. The solution is mixed with cement, slag, and fly ash, to form a grout, termed ``Saltstone``, that will be disposed in concrete vaults at the Saltstone Disposal Facility (SDF) [1]. Of the contaminants in the Saltstone, the greatest concern to SRS is the potential release of nitrate to the groundwater because of the high initial nitrate concentration (0.25 g/cm{sup 3}) in the Saltstone and the low Safe Drinking Water Act (SDWA) maximum contaminant level (MCL) of 44 mg/L. The SDF is designed to allow a slow, controlled release over thousands of years. This paper addresses a modeling study of nitrate migration from intact non-degraded concrete vaults in the unsaturated zone for the Radiological Performance Assessment (PA) of the SRS Saltstone Disposal Facility [3]. The PA addresses the performance requirements mandated by DOE Order 5820.2A [4].

  10. Inverse Temperature-Dependent Pathway of Cellulose Decrystallization...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Inverse Temperature-Dependent Pathway of Cellulose Decrystallization in Trifluoroacetic Acid. Inverse Temperature-Dependent Pathway of Cellulose Decrystallization in...

  11. Migration Behavior of Plutonium in Compacted Bentonite Under Reducing Condition Using Electromigration

    SciTech Connect (OSTI)

    Kazuya Idemitsu; Yosuke Yamasaki; Syeda Afsarun Nessa; Yaohiro Inagaki; Tatsumi Arima [Kyushu University, Fukuoka, 819-0395 (Japan); Toshiaki Mitsugashira; Mitsuo Hara; Yoshimitsu Suzuki [Tohoku University, Oarai, 311-1313 (Japan)

    2007-07-01T23:59:59.000Z

    Carbon steel is one of the candidate overpack materials for high-level waste disposal and is expected to assure complete containment of vitrified waste glass during an initial period of 1000 years in Japan. Carbon steel overpack will be corroded by consuming oxygen introduced by repository construction after closure of repository and then will keep the reducing environment in the vicinity of repository. The migration of iron corrosion products through the buffer material will affect migration of redox-sensitive radionuclides. Therefore the authors have carried out electromigration experiments with source of iron ions supplied by anode corrosion of iron coupons attached to compacted bentonite. Authors tried to use plutonium in this experimental configuration to obtain the knowledge of migration behavior of actinides. Authors also used cesium as reference. The concentrations of iron and sodium showed nearly complementary distributions. It is expected that iron ion could migrate as ferrous ion through the interlayer of montmorillonite replacing exchangeable sodium ions in the interlayer. Concentration profiles of plutonium in bentonite grew as time supplying electric potential as long as 168 h. Plutonium migrated from the iron anode toward cathode as deeper than 1 mm of the interior of bentonite even in 48 h, though plutonium could not diffuse 1 mm for 2 years. On the other hand, profiles of cesium were reported to be controlled by ordinary diffusion because of large diffusion coefficient of cesium in bentonite as large as 10{sup -12} m{sup 2}/s. Drift of the cesium profile by electric potential gradient could be observed clearly after 240 h at individual experiment for cesium. Apparent dispersion coefficients of plutonium were calculated from the profiles and were as large as 10{sup -13} m{sup 2}/s. Since plutonium migration was accelerated by electric potential, plutonium chemical species would have positive charge and were estimated as PuOH{sup 2+} or PuCl{sup 2+} by the thermodynamic calculation. Thus this experiment can provide a diffusion field for cations under a reducing condition with ferrous ions in water-saturated bentonite. (authors)

  12. Germany: Managing Migration in the 21st Century

    E-Print Network [OSTI]

    Martin, Philip L.

    2002-01-01T23:59:59.000Z

    1997 Ardaugh, John. 1987. Germany and the Germans. London:in 19th and 20th Century Germany. Berg Publishers. Bade,Past, Migration Future: Germany and the US. Providence. Berg

  13. Interprovincial Migration and the Stringency of Energy Policy in China

    E-Print Network [OSTI]

    Luo, Xiaohu

    2014-12-02T23:59:59.000Z

    Interprovincial migration flows involve substantial relocation of people and productive activity, with implications for regional energy use and greenhouse gas emissions. In China, these flows are not explicitly considered ...

  14. Quantitative studies of EGFR autocrine induced cell signaling and migration

    E-Print Network [OSTI]

    Joslin, Elizabeth Jane

    2007-01-01T23:59:59.000Z

    Epidermal growth factor (EGF) receptor autocrine and/or paracrine signaling plays an important role in normal epithelial cell proliferation, survival, adhesion and migration. Aberrant expression of the EGF receptor and its ...

  15. Inter-provincial Permanent and Temporary Migration in China

    E-Print Network [OSTI]

    Sun, Mingjie

    2011-01-01T23:59:59.000Z

    the role of migration in China's regional development and9: 485-502. Zhu, Yu. 2007. "China's floating population andThe settlement intention of China’s floating population in

  16. Wandering Neuronal Migration in the Postnatal Vertebrate Forebrain

    E-Print Network [OSTI]

    Scott, Benjamin B.

    Most non-mammalian vertebrate species add new neurons to existing brain circuits throughout life, a process thought to be essential for tissue maintenance, repair, and learning. How these new neurons migrate through the ...

  17. LONG TERM FILE MIGRATION - PART II: FILE REPLACEMENT ALGORITHMS

    E-Print Network [OSTI]

    Jay Smith, Alan

    2011-01-01T23:59:59.000Z

    MIGRATION· PART II: FILE REPLACEMENT ALGORITHMS Alan Jaymay vary even though replacement fi~~d the pa~ameter value PIe N - P ;, RT I r:. fILE REPLACEMENT ALGORITHMS. I.lan ~1ar

  18. Effects of interstitial flow on tumor cell migration

    E-Print Network [OSTI]

    Polacheck, William J. (William Joseph)

    2010-01-01T23:59:59.000Z

    Interstitial flow is the convective transport of fluid through tissue extracellular matrix. This creeping fluid flow has been shown to affect the morphology and migration of cells such as fibroblasts, cancer cells, endothelial ...

  19. Implementing Incremental Code Migration with XML Wolfgang Emmerich, Cecilia Mascolo

    E-Print Network [OSTI]

    Finkelstein, Anthony

    Implementing Incremental Code Migration with XML Wolfgang Emmerich, Cecilia Mascolo and Anthony Finkelstein Dept. of Computer Science University College London Gower Street, London WC1E 6BT, UK fW.Emmerich

  20. WORKING PAPER N 2009 -41 Migration and capital accumulation

    E-Print Network [OSTI]

    Boyer, Edmond

    , remittances, capital accumulation, rural poverty PARIS-JOURDAN SCIENCES ECONOMIQUES LABORATOIRE D. Key Words: Migration; Remittances; Capital Accumulation; Rural Poverty. Paris School of Economics (PSE) and Poverty Action Lab (J-PAL Europe), 48 Boulevard Jourdan, 75014 Paris, France. chiodi

  1. Pathways Analysis for State Proliferators

    E-Print Network [OSTI]

    Mella, Michael

    2012-07-16T23:59:59.000Z

    .60 93.4 Self Enriched Uranium True False 2.64 97.4 Acquire Feed Material true false 5.16 94.8 Found Depleted U true false 3.67 96.3 Sustainable Feed Source true false 2.54 97.5 Make..., a uranium path and a plutonium path. The uranium path involves enrichment pathways and leads to either a gun type weapon or implosion type weapon. The plutonium path involves reactors and reprocessing facilities and leads to an implosion weapon...

  2. Career Pathways | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube platformBuilding RemovalCSS Letter -SeptemberWorkshopby: Alan Career Pathways

  3. Estimating Migration Resistance: a Case Study of Greenlandic Arctic Terns

    E-Print Network [OSTI]

    Hensz, Christopher

    2013-01-15T23:59:59.000Z

    differences in environments along both paths Data ? Remote sensing: ? CCMP ocean winds ? AVHRR temperature ? AVHRR sea ice ? NPP layer 4 product ? Models: ? Linear exploration ? Circular-linear regression ? Non-linear regression m g C /m 2... d ay °C m /s Models ? Implemented in R ? Models: ? Linear exploration Southern Migration, 9 birds, n=929 Northern Migration, 9 birds, n=629 Future Directions 1: Finish non-linear model 2: Generalize procedure and include...

  4. Gas giant planets as dynamical barriers to inward-migrating super-Earths

    E-Print Network [OSTI]

    Izidoro, Andre; Morbidelli, Alessandro; Hersant, Franck; Pierens, Arnaud

    2015-01-01T23:59:59.000Z

    Planets of 1-4 times Earth's size on orbits shorter than 100 days exist around 30-50% of all Sun-like stars. In fact, the Solar System is particularly outstanding in its lack of "hot super-Earths" (or "mini-Neptunes"). These planets -- or their building blocks -- may have formed on wider orbits and migrated inward due to interactions with the gaseous protoplanetary disk. Here, we use a suite of dynamical simulations to show that gas giant planets act as barriers to the inward migration of super-Earths initially placed on more distant orbits. Jupiter's early formation may have prevented Uranus and Neptune (and perhaps Saturn's core) from becoming hot super-Earths. Our model predicts that the populations of hot super-Earth systems and Jupiter-like planets should be anti-correlated: gas giants (especially if they form early) should be rare in systems with many hot super-Earths. Testing this prediction will constitute a crucial assessment of the validity of the migration hypothesis for the origin of close-in supe...

  5. Efficient and flexible fault tolerance and migration of scientific simulation using CUMULVS

    SciTech Connect (OSTI)

    Kohl, J.A.; Papadopoulos, P.M.

    1998-05-01T23:59:59.000Z

    Many practical scientific applications would benefit from a simple checkpointing mechanism to provide automatic restart or recovery in response to faults and failures. CUMULVS is a middleware infrastructure for interacting with parallel scientific simulations to support online visualization and computational steering. The base CUMULVS system has been extended to provide a user-level mechanism for collecting checkpoints in a parallel simulation program. Via the same interface that CUMULVS uses to identify and describe data fields for visualization and parameters for steering, the user application can select the minimal program state necessary to restart or migrate an application task. The CUMULVS run-time system uses this information to efficiently recover fault-tolerant applications by restarting failed tasks. Application tasks can also be migrated -- even across heterogeneous architecture boundaries -- to achieve load balancing or to improve the task`s locality with a required resource. This paper describes the CUMULVS interface for checkpointing, the issues faced in utilizing this interface when developing fault-tolerant and migrating applications, and the direction of future research in this area.

  6. Cloud Migration: A Case Study of Migrating an Enterprise IT System to IaaS

    E-Print Network [OSTI]

    Khajeh-Hosseini, Ali; Sommerville, Ian

    2010-01-01T23:59:59.000Z

    This case study illustrates the potential benefits and risks associated with the migration of an IT system in the oil & gas industry from an in-house data center to Amazon EC2 from a broad variety of stakeholder perspectives across the enterprise, thus transcending the typical, yet narrow, financial and technical analysis offered by providers. Our results show that the system infrastructure in the case study would have cost 37% less over 5 years on EC2, and using cloud computing could have potentially eliminated 21% of the support calls for this system. These findings seem significant enough to call for a migration of the system to the cloud but our stakeholder impact analysis revealed that there are significant risks associated with this. Whilst the benefits of using the cloud are attractive, we argue that it is important that enterprise decision-makers consider the overall organizational implications of the changes brought about with cloud computing to avoid implementing local optimizations at the cost ...

  7. Combustion kinetics and reaction pathways

    SciTech Connect (OSTI)

    Klemm, R.B.; Sutherland, J.W. [Brookhaven National Laboratory, Upton, NY (United States)

    1993-12-01T23:59:59.000Z

    This project is focused on the fundamental chemistry of combustion. The overall objectives are to determine rate constants for elementary reactions and to elucidate the pathways of multichannel reactions. A multitechnique approach that features three independent experiments provides unique capabilities in performing reliable kinetic measurements over an exceptionally wide range in temperature, 300 to 2500 K. Recent kinetic work has focused on experimental studies and theoretical calculations of the methane dissociation system (CH{sub 4} + Ar {yields} CH{sub 3} + H + Ar and H + CH{sub 4} {yields} CH{sub 3} + H{sub 2}). Additionally, a discharge flow-photoionization mass spectrometer (DF-PIMS) experiment is used to determine branching fractions for multichannel reactions and to measure ionization thresholds of free radicals. Thus, these photoionization experiments generate data that are relevant to both reaction pathways studies (reaction dynamics) and fundamental thermochemical research. Two distinct advantages of performing PIMS with high intensity, tunable vacuum ultraviolet light at the National Synchrotron Light Source are high detection sensitivity and exceptional selectivity in monitoring radical species.

  8. The inflammatory mediator leukotriene D{sub 4} induces subcellular ?-catenin translocation and migration of colon cancer cells

    SciTech Connect (OSTI)

    Salim, Tavga [Division of Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Clinical Research Center, Skåne University Hospital, Malmö (Sweden); Sand-Dejmek, Janna [Division of Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Clinical Research Center, Skåne University Hospital, Malmö (Sweden); Section of Surgery, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö (Sweden); Bayer HealthCare, Pharmaceuticals Medical Affairs, Solna (Sweden); Sjölander, Anita, E-mail: anita.sjolander@med.lu.se [Division of Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Clinical Research Center, Skåne University Hospital, Malmö (Sweden)

    2014-02-15T23:59:59.000Z

    The abnormal activation of the Wnt/?-catenin pathway frequently occurs in colorectal cancer. The nuclear translocation of ?-catenin activates the transcription of target genes that promote cell proliferation, survival, and invasion. The pro-inflammatory mediator leukotriene D{sub 4} (LTD{sub 4}) exerts its effects through the CysLT{sub 1} receptor. We previously reported an upregulation of CysLT{sub 1}R in patients with colon cancer, suggesting the importance of leukotrienes in colon cancer. The aim of this study was to investigate the impact of LTD{sub 4} on Wnt/?-catenin signaling and its effects on proliferation and migration of colon cancer cells. LTD{sub 4} stimulation led to an increase in ?-catenin expression, ?-catenin nuclear translocation and the subsequent transcription of MYC and CCND1. Furthermore, LTD{sub 4} significantly reduced the expression of E-cadherin and ?-catenin at the plasma membrane and increased the migration and proliferation of HCT116 colon cancer cells. The effects of LTD{sub 4} can be blocked by the inhibition of CysLT{sub 1}R. Furthermore, LTD{sub 4} induced the inhibition of glycogen synthase kinase 3 (GSK)-3? activity, indicating a crosstalk between the G-protein-coupled receptor CysLT{sub 1} and the Wnt/?-catenin pathway. In conclusion, LTD{sub 4}, which can be secreted from macrophages and leukocytes in the tumor microenvironment, induces ?-catenin translocation and the activation of ?-catenin target genes, resulting in the increased proliferation and migration of colon cancer cells. - Highlights: • Leukotriene D{sub 4} (LTD{sub 4}) lowers membrane ?-catenin but increases nuclear ?-catenin levels in colon cancer cells. • In agreement, LTD{sub 4} triggers inactivation of GSK-3?, activation of TCF/LEF and increased expression of Cyclin D1 and c-Myc. • LTD{sub 4} also caused a significant reduction in the expression of E-cadherin and an increased migration of colon cancer cells.

  9. Fuel Dependence of Benzene Pathways

    SciTech Connect (OSTI)

    Zhang, H; Eddings, E; Sarofim, A; Westbrook, C

    2008-07-14T23:59:59.000Z

    The relative importance of formation pathways for benzene, an important precursor to soot formation, was determined from the simulation of 22 premixed flames for a wide range of equivalence ratios (1.0 to 3.06), fuels (C{sub 1}-C{sub 12}), and pressures (20 to 760 torr). The maximum benzene concentrations in 15 out of these flames were well reproduced within 30% of the experimental data. Fuel structural properties were found to be critical for benzene production. Cyclohexanes and C{sub 3} and C{sub 4} fuels were found to be among the most productive in benzene formation; and long-chain normal paraffins produce the least amount of benzene. Other properties, such as equivalence ratio and combustion temperatures, were also found to be important in determining the amount of benzene produced in flames. Reaction pathways for benzene formation were examined critically in four premixed flames of structurally different fuels of acetylene, n-decane, butadiene, and cyclohexane. Reactions involving precursors, such as C{sub 3} and C{sub 4} species, were examined. Combination reactions of C{sub 3} species were identified to be the major benzene formation routes with the exception of the cyclohexane flame, in which benzene is formed exclusively from cascading fuel dehydrogenation via cyclohexene and cyclohexadiene intermediates. Acetylene addition makes a minor contribution to benzene formation, except in the butadiene flame where C{sub 4}H{sub 5} radicals are produced directly from the fuel, and in the n-decane flame where C{sub 4}H{sub 5} radicals are produced from large alkyl radical decomposition and H atom abstraction from the resulting large olefins.

  10. San Francisco Estuary Striped Bass Migration History Determined by Electron-microprobe Analysis of Otolith Sr/Ca Ratio

    SciTech Connect (OSTI)

    Ostrach, D J; Phillis, C C; Weber, P K; Ingram, B L; Zinkl, J G

    2004-09-17T23:59:59.000Z

    Habitat use has been shown to be an important factor in the bioaccumulation of contaminants in striped bass. This study examines migration in striped bass as part of a larger study investigating bioaccumulation and maternal transfer of xenobiotics to progeny in the San Francisco Estuary system. Habitat use, residence time and spawning migration over the life of females (n = 23) was studied. Female striped bass were collected between Knights Landing and Colusa on the Sacramento River during the spawning runs of 1999 and 2001. Otoliths were removed, processed and aged via otolith microstructure. Subsequently, otoliths were analyzed for strontium/calcium (Sr/Ca) ratio using an electron-microprobe to measure salinity exposure and to distinguish freshwater, estuary, and marine habitat use. Salinity exposure during the last year before capture was examined more closely for comparison of habitat use by the maternal parent to contaminant burden transferred to progeny. Results were selectively confirmed by ion microprobe analyses for habitat use. The Sr/Ca data demonstrate a wide range of migratory patterns. Age of initial ocean entry differs among individuals before returning to freshwater, presumably to spawn. Some fish reside in freshwater year-round, while others return to more saline habitats and make periodic migrations to freshwater. Frequency of habitat shifts and residence times differs among fish, as well as over the lifetime of individual fish. While at least one fish spent its final year in freshwater, the majority of spawning fish spent their final year in elevated salinity. However, not all fish migrated to freshwater to spawn in the previous year. Results from this investigation concerning migration history in striped bass can be combined with contaminant and histological developmental analyses to better understand the bioaccumulation of contaminants and the subsequent effects they and habitat use have on fish populations in the San Francisco Estuary system.

  11. Hydrogen Pathway Cost Distributions Jim Uihlein

    E-Print Network [OSTI]

    Components Feedstock Production Delivery Total Delivered Hydrogen Cost Biomass Central Pipeline Distribution produce hydrogen at 300 psi · Liquefaction or pipeline compression included in delivery · Delivery costsHydrogen Pathway Cost Distributions Jim Uihlein Fuel Pathways Integration Tech Team January 25

  12. Process Design and Optimization of Biorefining Pathways 

    E-Print Network [OSTI]

    Bao, Buping

    2012-07-16T23:59:59.000Z

    of the various techniques developed in this work. The result shows 1, the optimal pathway based on minimum payback period for cost efficiency is pathway through alcohol fermentation and oligomerized to gasoline as 11.7 years with 1620 tonne/day of feedstock...

  13. Influence of Acidic and Alkaline Waste Solution Properties on Uranium Migration in Subsurface Sediments

    SciTech Connect (OSTI)

    Szecsody, James E.; Truex, Michael J.; Qafoku, Nikolla; Wellman, Dawn M.; Resch, Charles T.; Zhong, Lirong

    2013-08-01T23:59:59.000Z

    This study shows that acidic and alkaline wastes co-disposed with uranium into subsurface sediments has significant impact on changes in uranium retardation, concentration, and mass during downward migration. For uranium co-disposal with acidic wastes, significant rapid (i.e., hours) carbonate and slow (i.e., 100s of hours) clay dissolution resulted, releasing significant sediment-associated uranium, but the extent of uranium release and mobility change was controlled by the acid mass added relative to the sediment proton adsorption capacity. Mineral dissolution in acidic solutions (pH 2) resulted in a rapid (< 10 h) increase in aqueous carbonate (with Ca2+, Mg2+) and phosphate and a slow (100s of hours) increase in silica, Al3+, and K+, likely from 2:1 clay dissolution. Infiltration of uranium with a strong acid resulted in significant shallow uranium mineral dissolution and deeper uranium precipitation (likely as phosphates and carbonates) with downward uranium migration of three times greater mass at a faster velocity relative to uranium infiltration in pH neutral groundwater. In contrast, mineral dissolution in an alkaline environment (pH 13) resulted in a rapid (< 10 h) increase in carbonate, followed by a slow (10s to 100s of hours) increase in silica concentration, likely from montmorillonite, muscovite, and kaolinite dissolution. Infiltration of uranium with a strong base resulted in uranium-silicate precipitation (presumed Na-boltwoodite) but also desorption of natural uranium on the sediment due to the high ionic strength solution, or 60% greater mass with greater retardation compared with groundwater. Overall, these results show that acidic or alkaline co-contaminant disposal with uranium can result in complex depth- and time-dependent changes in uranium dissolution/precipitation reactions and uranium sorption, which alter the uranium migration mass, concentration, and velocity.

  14. Syngas Upgrading to Hydrocarbon Fuels Technology Pathway

    SciTech Connect (OSTI)

    Talmadge, M.; Biddy, M.; Dutta, A.; Jones, S.; Meyer, A.

    2013-03-01T23:59:59.000Z

    This technology pathway case investigates the upgrading of woody biomass derived synthesis gas (syngas) to hydrocarbon biofuels. While this specific discussion focuses on the conversion of syngas via a methanol intermediate to hydrocarbon blendstocks, there are a number of alternative conversion routes for production of hydrocarbons through a wide array of intermediates from syngas. Future work will also consider the variations to this pathway to determine the most economically viable and lowest risk conversion route. Technical barriers and key research needs have been identified that should be pursued for the syngas-to-hydrocarbon pathway to be competitive with petroleum-derived gasoline-, diesel- and jet-range hydrocarbon blendstocks.

  15. 2011 Pathways to Commercial Success: Technologies and Products...

    Energy Savers [EERE]

    1 Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Program 2011 Pathways to Commercial Success: Technologies and Products Supported...

  16. 2013 Pathways to Commercial Success: Technologies and Products...

    Energy Savers [EERE]

    2013 Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Office 2013 Pathways to Commercial Success: Technologies and Products...

  17. 2014 Pathways to Commercial Success: Technologies and Products...

    Energy Savers [EERE]

    2014 Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Office 2014 Pathways to Commercial Success: Technologies and Products...

  18. Molecular Dynamics Study of the Proposed Proton Transport Pathways...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Dynamics Study of the Proposed Proton Transport Pathways in FeFe-Hydrogenase. Molecular Dynamics Study of the Proposed Proton Transport Pathways in FeFe-Hydrogenase. Abstract:...

  19. acid signaling pathways: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    signaling pathways MIT - DSpace Summary: Cells communicate with other cells, and process cues from their environment, via signaling pathways, in which extracellular cues...

  20. anemia pathway signaling: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    signaling pathways MIT - DSpace Summary: Cells communicate with other cells, and process cues from their environment, via signaling pathways, in which extracellular cues...

  1. angiotensin signaling pathway: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    signaling pathways MIT - DSpace Summary: Cells communicate with other cells, and process cues from their environment, via signaling pathways, in which extracellular cues...

  2. ahr signaling pathway: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    signaling pathways MIT - DSpace Summary: Cells communicate with other cells, and process cues from their environment, via signaling pathways, in which extracellular cues...

  3. SciTech Connect: Possible Pathways for Increasing Natural Gas...

    Office of Scientific and Technical Information (OSTI)

    Conference: Possible Pathways for Increasing Natural Gas Use for Transportation (Presentation) Citation Details In-Document Search Title: Possible Pathways for Increasing Natural...

  4. Techno-Economic Boundary Analysis of Biological Pathways to Hydrogen...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Techno-Economic Boundary Analysis of Biological Pathways to Hydrogen Production (2009) Techno-Economic Boundary Analysis of Biological Pathways to Hydrogen Production (2009)...

  5. Rotary Vapor Compression Cycle Technology: A Pathway to Ultra...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Cycle Technology: A Pathway to Ultra-Efficient Air Conditioning, Heating and Refrigeration Rotary Vapor Compression Cycle Technology: A Pathway to Ultra-Efficient Air...

  6. Bioenergy Technologies Office R&D Pathways: Algal Lipid Upgrading...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Algal Biofuels Algal Lipid Extraction and Upgrading to Hydrocarbons Technology Pathway Bioenergy Technologies Office Conversion R&D Pathway: Whole Algae Hydrothermal Liquefaction...

  7. Biotic and abiotic pathways of phosphorus cycling in minerals...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and abiotic pathways of phosphorus cycling in minerals and sediments: insights from oxygen isotopes in phosphate. Biotic and abiotic pathways of phosphorus cycling in minerals...

  8. Energy Department Launches Web Tool to Explore Pathways to Clean...

    Broader source: Energy.gov (indexed) [DOE]

    Energy Department Launches Web Tool to Explore Pathways to Clean Energy Economy Energy Department Launches Web Tool to Explore Pathways to Clean Energy Economy January 15, 2013 -...

  9. 2009 Pathways to Commercial Success: Technologies and Products...

    Office of Environmental Management (EM)

    Pathways to Commercial Success: Technologies and Products Supported by the Hydrogen, Fuel Cells and Infrastructure Technologies Program 2009 Pathways to Commercial Success:...

  10. Hydrogen Supply: Cost Estimate for Hydrogen Pathways-Scoping...

    Broader source: Energy.gov (indexed) [DOE]

    Supply: Cost Estimate for Hydrogen Pathways-Scoping Analysis. January 22, 2002-July 22, 2002 Hydrogen Supply: Cost Estimate for Hydrogen Pathways-Scoping Analysis. January 22,...

  11. Outlook export contacts and groups Migrate Outlook Contacts to gmail

    E-Print Network [OSTI]

    Aalberts, Daniel P.

    Outlook export contacts and groups Migrate Outlook Contacts to gmail 1. In Outlook 2007 on the File menu, click Import and Export. 1a. For Outlook 2010 on the File menu, click Open, then Import 2. Click Export to a file, and then click Next. #12;3. Click Comma Separated Values (Windows), and then click Next

  12. Traces of Human Migrations in Helicobacter pylori Populations

    E-Print Network [OSTI]

    Wirth, Thierry

    Traces of Human Migrations in Helicobacter pylori Populations Daniel Falush,1 Thierry Wirth,1 Bodo Reichard,1 Elena Katzowitsch,8 Xiaoyan Wang,1 Mark Achtman,1 * Sebastian Suerbaum8 Helicobacter pylori tuberculosis (2), Haemophilus influenzae (3), and Helicobac- ter pylori (4­8). H. pylori, a Gram

  13. Fluid Migration During Ice/Rock Planetesimal Differentiation

    E-Print Network [OSTI]

    Raney, Robert 1987-

    2012-12-12T23:59:59.000Z

    /water reaction, which will depend on the rate at which water can be segregated from a melting ice/rock core. For the liquid water phase to migrate toward the surface, the denser rock phase must compact. The primary question that this thesis will answer is how...

  14. Migration and animal husbandry: Competing or complementary livelihood strategies.

    E-Print Network [OSTI]

    Richner, Heinz

    Kyrgyzstan Nadia Schoch, Bernd Steimann and Susan Thieme Abstract Animal husbandry and labour migration; their interlinkages have rarely been examined. Based on a case study in rural Kyrgyzstan, the aim of this paper; Kyrgyzstan. 1. Introduction Processes of agrarian transformations within and across countries have changed

  15. ORIGINAL PAPER Granite magma migration and emplacement along thrusts

    E-Print Network [OSTI]

    Galland, Olivier

    ORIGINAL PAPER Granite magma migration and emplacement along thrusts Eric C. Ferre´ · Olivier in the emplacement of granite plutons in contractional settings. We address both cases where contractional tectonics. This phenomenon occurs for both low-viscosity magma (basalts to andesite) and high-viscosity magma (dry granite

  16. Leveraging Load Migration and Basestaion Consolidation for Green Communications in

    E-Print Network [OSTI]

    Tang, Jian "Neil"

    as a useful technology for improving resource utilization and power efficiency. For example, in a virtualized power-efficient BSs in its neighborhood such that idle BSs can be turned off or put into sleep to save power. In this paper, we propose to leverage load migration and BS consolidation for green

  17. Migration Health MIDSA Report -December 2009 Table of Contents

    E-Print Network [OSTI]

    Abolmaesumi, Purang

    -Sectoral Approach . . . . . . . . . . . . . . . . . . . . . . . 17 5.5 PHC Reform and Provision of Health Service . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 5.10 Burden on Health Care System . . . . . . . . . . . . . . . . . . . 18 5.11 Condom#12;Migration Health MIDSA Report - December 2009 Table of Contents 1 Foreword 1 2 Acronyms 3 3

  18. Tier II Canada Research Chair Migration and Ethnic Relations

    E-Print Network [OSTI]

    Sinnamon, Gordon J.

    Tier II Canada Research Chair in Migration and Ethnic Relations Faculty of Social Science Western University The Faculty of Social Science at Western University invites applications for a Tier II Canada for Tier II Canada Research Chairs, the candidate will hold a PhD (obtained within the last ten years

  19. Performance and Energy Modeling for Live Migration of Virtual Machines

    E-Print Network [OSTI]

    Xu, Cheng-Zhong

    Performance and Energy Modeling for Live Migration of Virtual Machines Haikun Liu , Cheng-Zhong Xu , Hai Jin , Jiayu Gong , Xiaofei Liao School of Computer Science and Technology Huazhong University of Science and Technology Wuhan, 430074, China {hjin, xfliao}@hust.edu.cn Department of Electrical

  20. Intramolecular hydride migration from formyl to carbonyl and nitrene ligands

    SciTech Connect (OSTI)

    Luan, L.; Brookhart, M.; Templeton, J.L. [Univ. of North Carolina, Chapel Hill, NC (United States)

    1992-04-01T23:59:59.000Z

    Reaction of [Tp{prime}W(CO){sub 2}(NPh)][PF{sub 6}] [Tp{prime} = hydrotris(3,5-dimethylpyrazolyl)borate] with lithium borohydride at -40 {degrees}C generates Tp{prime}W(CO)(Nph)(CHO) (1), which undergoes hydride migration from carbon to nitrogen (at -70 {degrees}C, k{sub obs} = 7.2 x 10{sup -6} s{sup -1}, {Delta}G{sup {double_dagger}} = 16.5 kcal/mol, t{sub {1/2}} = 27 h) to form Tp{prime}W(CO){sub 2}(NHPh). Crossover experiments indicate that the hydride migration is intramolecular. The metal formyl intermediate is fluxional; hydride migration interconverts the formyl and carbonyl ligands. The rate constant for this degenerate migration is 40 s{sup -1} at -41 {degrees}C with {Delta}G{sup {double_dagger}} = 11.7 kcal/mol. The analogous acyl complex Tp{prime}W(CO)(Nph)[C(O)Ph] (3) has been synthesized from the reaction of [Tp{prime}W(CO){sub 2}-(NPh)][PF{sub 6}] with PhMgBr. 9 refs.

  1. Greening the Cloud Using Renewable-Energy-Aware Service Migration*

    E-Print Network [OSTI]

    California at Davis, University of

    1 Greening the Cloud Using Renewable-Energy-Aware Service Migration* Uttam Mandal, M. Farhan Habib this energy consumption, and hence, carbon footprint and green house gas emission of cloud computing, is contributing to increased energy consumption, and hence, carbon footprint and green house gas emission

  2. THE COMPOSITIONAL DIVERSITY OF EXTRASOLAR TERRESTRIAL PLANETS. II. MIGRATION SIMULATIONS

    SciTech Connect (OSTI)

    Carter-Bond, Jade C. [School of Physics, University of New South Wales, Kensington, NSW 2052 (Australia); O'Brien, David P. [Planetary Science Institute, 1700 East Fort Lowell, Tucson, AZ 85719 (United States); Raymond, Sean N., E-mail: j.bond@unsw.edu.au [Observatoire Aquitain des Sciences de l'Univers, Universite de Bordeaux, 2 rue de l'Observatoire, BP 89, F-33271 Floirac Cedex (France)

    2012-11-20T23:59:59.000Z

    Prior work has found that a variety of terrestrial planetary compositions are expected to occur within known extrasolar planetary systems. However, such studies ignored the effects of giant planet migration, which is thought to be very common in extrasolar systems. Here we present calculations of the compositions of terrestrial planets that formed in dynamical simulations incorporating varying degrees of giant planet migration. We used chemical equilibrium models of the solid material present in the disks of five known planetary host stars: the Sun, GJ 777, HD4203, HD19994, and HD213240. Giant planet migration has a strong effect on the compositions of simulated terrestrial planets as the migration results in large-scale mixing between terrestrial planet building blocks that condensed at a range of temperatures. This mixing acts to (1) increase the typical abundance of Mg-rich silicates in the terrestrial planets' feeding zones and thus increase the frequency of planets with Earth-like compositions compared with simulations with static giant planet orbits, and (2) drastically increase the efficiency of the delivery of hydrous phases (water and serpentine) to terrestrial planets and thus produce waterworlds and/or wet Earths. Our results demonstrate that although a wide variety of terrestrial planet compositions can still be produced, planets with Earth-like compositions should be common within extrasolar planetary systems.

  3. Computation Migration based on Mobile IP and Intelligent Agent Techniques

    E-Print Network [OSTI]

    Zhang, Runtong

    Page 1 Computation Migration based on Mobile IP and Intelligent Agent Techniques Runtong Zhang, Dongmei Zhang, Zhigang Kan and Jian Ma Advanced Internet Technology, Nokia (China) R&D Center No. 11, He is to investigate the use of mobile agents in the platform of mobile IPv6, to provide adapted services to mobile

  4. NAWIPS/GEMPAK Migration to AWIPS-II

    E-Print Network [OSTI]

    ;2 TOPICS · Background · Raytheon Code issues · Schedule · Major Tasks for NCEP · GEMPAK 6.0 · Suggested decoders/encoders, D2D, GFE, Hydro Apps, etc. #12;5 Background · N-AWIPS migration will leverage Raytheon;6 Raytheon Code Issues · Both NCEP and Unidata are waiting for the NWS and Raytheon to reach agreement

  5. 27 Migration,Poverty,Security andSocialNetworks:ACentral

    E-Print Network [OSTI]

    Richner, Heinz

    417 27 Migration,Poverty,Security andSocialNetworks:ACentral AmericanPerspective Abelardo Morales introduction to understanding the migra- tion­poverty relationship from a different perspective, i of inequality and as a resource for poverty alleviation strategies, from a Central American perspective

  6. Reply to Engelder: Potential for fluid migration from the Marcellus

    E-Print Network [OSTI]

    Jackson, Robert B.

    LETTER Reply to Engelder: Potential for fluid migration from the Marcellus Formation remains) and brines by imbibition and capillary binding seals the Marcellus Formation and precludes the flow of fluids between the Marcellus Formation and shallow aquifers in northeastern Pennsylvania (2). First, considerable

  7. THEORETICAL EFFECT OF BENTONITE MIGRATION ON CONTAMINANT TRANSPORT

    E-Print Network [OSTI]

    THEORETICAL EFFECT OF BENTONITE MIGRATION ON CONTAMINANT TRANSPORT THROUGH GEOSYNTHETIC CLAY LINERS TRANSPORT THROUGH GEOSYNTHETIC CLAY LINERS Jason H. FitzSimmons1 and Timothy D. Stark2 ABSTRACT: Since the introduction of geosynthetic clay liners (GCLs) to waste containment facilities, one of the major concerns

  8. Stefan Salzmann Migration for education: Studying abroad and return to the home country.

    E-Print Network [OSTI]

    Richner, Heinz

    migration for education and therewith of overall migration issues regarding post-soviet Kyrgyzstan-structured interviews with post graduates between one and to five years after they had returned to Kyrgyzstan. While

  9. Pressure solution and microfracturing in primary oil migration, upper cretaceous Austin Chalk, Texas Gulf Coast

    E-Print Network [OSTI]

    Chanchani, Jitesh

    1994-01-01T23:59:59.000Z

    to oil generation offers a possible explanation for the mechanism of the primary migration of oil in the Austin Chalk. Detailed petrographic analysis was undertaken to study the primary migration of oil in the Austin Chalk. The important components...

  10. Short-term Migration, Rural Workfare Programs and Urban Labor Markets: Evidence from India

    E-Print Network [OSTI]

    Bandyopadhyay, Antar

    , a simple calibration exercise reveals that small changes in short-term migration can have large impacts of migration in developing countries (Banerjee and Duo, 2007; Badiani and Sar, 2009; Morten, 2012). In 2007

  11. Development and application of chemical tools for investigating dynamic processes in cell migration

    E-Print Network [OSTI]

    Goguen, Brenda Nicole

    2011-01-01T23:59:59.000Z

    Cell migration is a dynamic process essential for many fundamental physiological functions, including wound repair and the immune response. Migration relies on precisely orchestrated events that are regulated in a spatially ...

  12. Computer Modeling Illuminates Degradation Pathways of

    E-Print Network [OSTI]

    Computer Modeling Illuminates Degradation Pathways of Cations in Alkaline Membrane Fuel Cells Cation degradation insights obtained by computational modeling could result in better performance are effective in increasing cation stability. With the help of computational modeling, more cations are being

  13. Fuel Pathway Integration Technical Team Roadmap

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Fuel Pathway Integration Technical Team Roadmap June 2013 This roadmap is a document of the U.S. DRIVE Partnership. U.S. DRIVE (Driving Research and Innovation for Vehicle...

  14. A thermodynamic analysis of trinitotoluene biodegradation pathways

    E-Print Network [OSTI]

    Shelley, Mark Dewey

    1995-01-01T23:59:59.000Z

    free energy change of reaction was calculated for each pathway step using a group contribution method specifically tailored for biomolecules. Steps with large negative Gibbs free energy changes are assumed to be potentially rate-controlling. Therefore...

  15. Assessment tool for nuclear material acquisition pathways

    E-Print Network [OSTI]

    Ford, David Grant

    2009-05-15T23:59:59.000Z

    ................ 24 Figure 13 HEU area of the pathways network showing the various chemical forms of uranium that can be enriched ...........................................................................25 Figure 14 Section of the network showing pathways... be obtained. The two types of material used in nuclear weapons are Highly Enriched Uranium (HEU) and Plutonium (Pu). Uranium is an element found in nature and is contained in the soil all over the world. However, certain geological formations contain a...

  16. Determinants and Income Effects of Commuting and Migration An empirical analysis for Germany after Unification

    E-Print Network [OSTI]

    Pfeifer, Holger

    Determinants and Income Effects of Commuting and Migration An empirical analysis for Germany after differentials between East and West Germany led to massive commuting and migration flows. In this paper we: Human capital and income, Germany, commuting, migration, GSOEP JEL No.: J31, J61, O15 Address: Institute

  17. Migrate Roles and Features to Windows Server 2012 R2 or

    E-Print Network [OSTI]

    Hunt, Galen

    #12;Migrate Roles and Features to Windows Server 2012 R2 or Windows Server 2012 Summary: This E-Book includes guidance to help you migrate server roles and features to Windows Server 2012 R2 or Windows Server 2012. Also included is an installation and operations guide for Windows Server Migration Tools, a set

  18. Physical Machine State Migration Jui-Hao Chiang, Maohua Lu, Tzi-cker Chiueh

    E-Print Network [OSTI]

    Chiueh, Tzi-cker

    machine to another. This physical machine state migration (PMSM) capability greatly decreases the amount.g., the hypervisor in the case of VM migration. The PMSM prototype described in this paper is adapted from Linux's hibernation facility. The current PMSM prototype can migrate a physical machine running the MySQL DBMS server

  19. Waste Isolation Pilot Plant No-Migration Variance Petition. Revision 1, Volume 1

    SciTech Connect (OSTI)

    Hunt, Arlen

    1990-03-01T23:59:59.000Z

    The purpose of the WIPP No-Migration Variance Petition is to demonstrate, according to the requirements of RCRA {section}3004(d) and 40 CFR {section}268.6, that to a reasonable degree of certainty, there will be no migration of hazardous constituents from the facility for as long as the wastes remain hazardous. The DOE submitted the petition to the EPA in March 1989. Upon completion of its initial review, the EPA provided to DOE a Notice of Deficiencies (NOD). DOE responded to the EPA`s NOD and met with the EPA`s reviewers of the petition several times during 1989. In August 1989, EPA requested that DOE submit significant additional information addressing a variety of topics including: waste characterization, ground water hydrology, geology and dissolution features, monitoring programs, the gas generation test program, and other aspects of the project. This additional information was provided to EPA in January 1990 when DOE submitted Revision 1 of the Addendum to the petition. For clarity and ease of review, this document includes all of these submittals, and the information has been updated where appropriate. This document is divided into the following sections: Introduction, 1.0: Facility Description, 2.0: Waste Description, 3.0; Site Characterization, 4.0; Environmental Impact Analysis, 5.0; Prediction and Assessment of Infrequent Events, 6.0; and References, 7.0.

  20. Smolt Monitoring Program, Part II, Volume II, Migrational Characteristics of Columbia Basin Salmon and Steelhead Trout, 1985 Annual Report.

    SciTech Connect (OSTI)

    Fish Passage Center

    1986-02-01T23:59:59.000Z

    Volume I of this report describes the results of travel time monitoring and other migrational characteristics of yearling and sub-yearling chinook salmon (Oncorhynchus tshawytscha), sockeye salmon (Oncorhynchus nerka), and steelhead trout (Salmo gairdneri). This volume presents the freeze brand data used in the analysis of travel time for Lower Granite, Rock Island, McNary, and John Day dams. Brand recoveries for Lower Monumental dam also are presented. Summary of data collection procedures and explanation of data listings are presented in conjunction with the mark recapture data.

  1. Instabilities during liquid migration into superheated hydrothermal systems

    SciTech Connect (OSTI)

    Fitzgerald, Shaun D.; Woods, Andrew W.

    1995-01-26T23:59:59.000Z

    Hydrothermal systems typically consist of hot permeable rock which contains either liquid or liquid and saturated steam within the voids. These systems vent fluids at the surface through hot springs, fumaroles, mud pools, steaming ground and geysers. They are simultaneously recharged as meteoric water percolates through the surrounding rock or through the active injection of water at various geothermal reservoirs. In a number of geothermal reservoirs from which significant amounts of hot fluid have been extracted and passed through turbines, superheated regions of vapor have developed. As liquid migrates through a superheated region of a hydrothermal system, some of the liquid vaporizes at a migrating liquid-vapor interface. Using simple physical arguments, and analogue laboratory experiments we show that, under the influence of gravity, the liquid-vapor interface may become unstable and break up into fingers.

  2. A Migrated Aortic Stent Graft Causing Erosive Spondylopathy

    SciTech Connect (OSTI)

    Gestrich, Christopher, E-mail: christopher.gestrich@ukb.uni-bonn.de; Probst, Chris, E-mail: chris.probst@ukb.uni-bonn.de [Universitaetsklinikum Bonn, Department of Cardiac Surgery (Germany)] [Universitaetsklinikum Bonn, Department of Cardiac Surgery (Germany); Wilhelm, Kai, E-mail: kai.wilhelm@ek-bonn.de [Johanniterkrankenhaus Bonn, Department of Radiology (Germany)] [Johanniterkrankenhaus Bonn, Department of Radiology (Germany); Schiller, Wolfgang, E-mail: wolfgang.schiller@ukb.uni-bonn.de [Universitaetsklinikum Bonn, Department of Cardiac Surgery (Germany)] [Universitaetsklinikum Bonn, Department of Cardiac Surgery (Germany)

    2013-12-15T23:59:59.000Z

    We report about a patient presenting with back pain 4 months after an uneventful endovascular implantation of an aortic stent graft. Computed tomography scan revealed a migration of the stent with consecutive endoleakage, kink formation, and movement of the stent toward the spine, which caused destruction of the aortic wall as well as vertebral necrosis. Explantation of the stent and replacement of the native aorta relieved the patient of his symptoms.

  3. Migrating to Autodesk MapGuide Enterprise 2008

    E-Print Network [OSTI]

    Ahmad, Sajjad

    Migration Autodesk MapGuide SDF 2 Files MapGuide 6.5 SDF 2.0 files were created with either Map 3D (manually) or using the Autodesk MapGuide 6.5 SDF Loader. Since MapGuide 2008 requires SDF 3.0 or higher versions, the SDF files will have to either be recreated with Map 3D or by using Load Procedures with Map

  4. Subpage migration and replication in CC-NUMA multiprocessors

    E-Print Network [OSTI]

    Nadaanayakinahalu, Sudhindra

    1999-01-01T23:59:59.000Z

    . . . . . . . . . . 1. Multiple sub-pages per page scheme 2. Partial page (sub-page) invalidation scheme. . . . . . B. Hardware Supported Page Migration and Replication 1. Directory controller 2. Counter hardware 3. TLB and page table . 4. Page mover . 5... 1. Ocean 2. Raytrace 3. Fast Fourier Transforms (FFT) 4. Water spatial . . 5. MP3D 1. Processor features 2. Memory features 3. Multiprocessor features RSIM Memory and Directory Subsystem RSIM Configuration Parameters and Values 33 33 33...

  5. A Model for Blood Coagulation and Lysis Utilizing the Intrinsic and Extrinsic Pathways

    E-Print Network [OSTI]

    Lacroix, Daniel Edward

    2012-07-16T23:59:59.000Z

    ) and ?(350)(blue line)???????? 59 Figure 9: Thrombin concentration at the clot surface versus time?????? 60 Figure 10: Fibrin concentration at the clot surface versus time??????? 61 Figure 11: Clot size versus time. The extrinsic pathway only... bacterial infection as well as helping to rid the body of unnecessary (and therefore unwanted) extracellular deposits as well as damaged tissue. As neutrophils begin to fight infection they release granule enzymes, an oxidase, H2O2, and several lipids...

  6. Modeling the secular evolution of migrating planet pairs

    E-Print Network [OSTI]

    Michtchenko, Tatiana A

    2011-01-01T23:59:59.000Z

    The subject of this paper is the secular behaviour of a pair of planets evolving under dissipative forces. In particular, we investigate the case when dissipative forces affect the planetary semi-major axes and the planets move inward/outward the central star, in a process known as planet migration. To perform this investigation, we introduce fundamental concepts of conservative and dissipative dynamics of the three-body problem. Based on these concepts, we develop a qualitative model of the secular evolution of the migrating planetary pair. Our approach is based on analysis of the energy and the orbital angular momentum exchange between the two-planet system and an external medium; thus no specific kind of dissipative forces is invoked. We show that, under assumption that dissipation is weak and slow, the evolutionary routes of the migrating planets are traced by the Mode I and Mode II stationary solutions of the conservative secular problem. The ultimate convergence and the evolution of the system along one...

  7. Ion beam analyses of radionuclide migration in heterogeneous rocks

    SciTech Connect (OSTI)

    Alonso, Ursula; Missana, Tiziana; Garcia-Gutierrez, Miguel [CIEMAT, Avda. Complutense 40, Madrid 28040 (Spain); Patelli, Alessandro [CIVEN, Via delle Industrie 5, Venezia-Marghera 30175 (Italy); Rigato, Valentino; Ceccato, Daniele [LNL-INFN, Viale dell' Universita 2, Legnaro-Padova 35020 (Italy)

    2013-07-18T23:59:59.000Z

    The migration of radionuclides (RN) in the environment is a topic of general interest, for its implications on public health, and it is an issue for the long-term safety studies of deep geological repositories (DGR) for high-level radioactive waste. The role played by colloids on RN migration is also of great concern. Diffusion and sorption are fundamental mechanisms controlling RN migration in rocks and many experimental approaches are applied to determine transport parameters for low sorbing RN in homogeneous rocks. However, it is difficult to obtain relevant data for high sorbing RN or colloids, for which diffusion lengths are extremely short, or within heterogeneous rocks, where transport might be different in different minerals. The ion beam techniques Rutherford Backscattering Spectrometry (RBS) and micro-Particle Induced X-Ray Emission ({mu}PIXE), rarely applied in the field, were selected for their micro-analytical potential to study RN diffusion and surface retention within heterogeneous rocks. Main achievements obtained during last 12 years are highlighted.

  8. Stochastic Control of Metabolic Pathways

    E-Print Network [OSTI]

    Andrea Rocco

    2009-06-01T23:59:59.000Z

    We study the effect of extrinsic noise in metabolic networks. We introduce external random fluctuations at the kinetic level, and show how these lead to a stochastic generalization of standard Metabolic Control Analysis. While Summation and Connectivity Theorems hold true in presence of extrinsic noise, control coefficients incorporate its effect through an explicit dependency on the noise intensity. New elasticities and response coefficients are also defined. Accordingly, the concept of control by noise is introduced as a way of tuning the systemic behaviour of metabolisms. We argue that this framework holds for intrinsic noise too, when time-scale separation is present in the system.

  9. Homocysteine enhances MMP-9 production in murine macrophages via ERK and Akt signaling pathways

    SciTech Connect (OSTI)

    Lee, Seung Jin; Lee, Yi Sle; Seo, Kyo Won; Bae, Jin Ung; Kim, Gyu Hee; Park, So Youn; Kim, Chi Dae, E-mail: chidkim@pusan.ac.kr

    2012-04-01T23:59:59.000Z

    Homocysteine (Hcy) at elevated levels is an independent risk factor of cardiovascular diseases, including atherosclerosis. In the present study, we investigated the effect of Hcy on the production of matrix metalloproteinases (MMP) in murine macrophages. Among the MMP known to regulate the activities of collagenase and gelatinase, Hcy exclusively increased the gelatinolytic activity of MMP-9 in J774A.1 cells as well as in mouse peritoneal macrophages. Furthermore, this activity was found to be correlated with Western blot findings in J774A.1 cells, which showed that MMP-9 expression was concentration- and time-dependently increased by Hcy. Inhibition of the ERK and Akt pathways led to a significant decrease in Hcy-induced MMP-9 expression, and combined treatment with inhibitors of the ERK and Akt pathways showed an additive effects. Activity assays for ERK and Akt showed that Hcy increased the phosphorylation of both, but these phosphorylation were not affected by inhibitors of the Akt and ERK pathways. In line with these findings, the molecular inhibition of ERK and Akt using siRNA did not affect the Hcy-induced phosphorylation of Akt and ERK, respectively. Taken together, these findings suggest that Hcy enhances MMP-9 production in murine macrophages by separately activating the ERK and Akt signaling pathways. -- Highlights: ? Homocysteine (Hcy) induced MMP-9 production in murine macrophages. ? Hcy induced MMP-9 production through ERK and Akt signaling pathways. ? ERK and Akt signaling pathways were activated by Hcy in murine macrophages. ? ERK and Akt pathways were additively act on Hcy-induced MMP-9 production. ? Hcy enhances MMP-9 production in macrophages via activation of ERK and Akt signaling pathways in an independent manner.

  10. Migration of antimony from PET trays into food simulant and food: determination of Arrhenius parameters and comparison of predicted and measured migration data

    E-Print Network [OSTI]

    Short, Daniel

    Migration of antimony from PET trays into food simulant and food: determination of Arrhenius) Migration experiments with small sheets cut out from ovenable PET trays were performed in two-sided contact) was estimated to be 62% in the PET sample under study. Apparent diffusion coefficients of Sb in PET trays were

  11. Infrastructure Required for Tag/Mark Application, Detection, and Recovery Tag/Mark & release Juvenile fish migration Adult fish migration Mortality*Ocean residency

    E-Print Network [OSTI]

    Juvenile fish migration Adult fish migration Mortality*Ocean residency Adipose fin clip Marking trailers N processing Otolith Insulated box, thermal chilling system, lab processing, smolt traps N/A Fish traps, fish *Fish mortality data may be collected at any stage of the fish life cycle from harvest, recovered

  12. Tamoxifen inhibits tumor cell invasion and metastasis in mouse melanoma through suppression of PKC/MEK/ERK and PKC/PI3K/Akt pathways

    SciTech Connect (OSTI)

    Matsuoka, Hiroshi [Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi-Osaka 577-8502 (Japan) [Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi-Osaka 577-8502 (Japan); Department of Pharmacy, Nara Hospital, Kinki University School of Medicine, 1248-1 Ikoma, Nara 630-0293 (Japan); Tsubaki, Masanobu [Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi-Osaka 577-8502 (Japan)] [Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi-Osaka 577-8502 (Japan); Yamazoe, Yuzuru [Department of Pharmacy, Kinki University Hospital, Osakasayama, Osaka 589-8511 (Japan)] [Department of Pharmacy, Kinki University Hospital, Osakasayama, Osaka 589-8511 (Japan); Ogaki, Mitsuhiko [Department of Pharmacy, Higahiosaka City General Hospital, Higashi-osaka, Osaka 578-8588 (Japan)] [Department of Pharmacy, Higahiosaka City General Hospital, Higashi-osaka, Osaka 578-8588 (Japan); Satou, Takao; Itoh, Tatsuki [Department of Pathology, Kinki University School of Medicine, Osakasayama, Osaka 589-8511 (Japan)] [Department of Pathology, Kinki University School of Medicine, Osakasayama, Osaka 589-8511 (Japan); Kusunoki, Takashi [Department of Otolaryngology, Juntendo University School of Medicine, Tokyo (Japan)] [Department of Otolaryngology, Juntendo University School of Medicine, Tokyo (Japan); Nishida, Shozo, E-mail: nishida@phar.kindai.ac.jp [Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi-Osaka 577-8502 (Japan)] [Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi-Osaka 577-8502 (Japan)

    2009-07-15T23:59:59.000Z

    In melanoma, several signaling pathways are constitutively activated. Among these, the protein kinase C (PKC) signaling pathways are activated through multiple signal transduction molecules and appear to play major roles in melanoma progression. Recently, it has been reported that tamoxifen, an anti-estrogen reagent, inhibits PKC signaling in estrogen-negative and estrogen-independent cancer cell lines. Thus, we investigated whether tamoxifen inhibited tumor cell invasion and metastasis in mouse melanoma cell line B16BL6. Tamoxifen significantly inhibited lung metastasis, cell migration, and invasion at concentrations that did not show anti-proliferative effects on B16BL6 cells. Tamoxifen also inhibited the mRNA expressions and protein activities of matrix metalloproteinases (MMPs). Furthermore, tamoxifen suppressed phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt through the inhibition of PKC{alpha} and PKC{delta} phosphorylation. However, other signal transduction factor, such as p38 mitogen-activated protein kinase (p38MAPK) was unaffected. The results indicate that tamoxifen suppresses the PKC/mitogen-activated protein kinase kinase (MEK)/ERK and PKC/phosphatidylinositol-3 kinase (PI3K)/Akt pathways, thereby inhibiting B16BL6 cell migration, invasion, and metastasis. Moreover, tamoxifen markedly inhibited not only developing but also clinically evident metastasis. These findings suggest that tamoxifen has potential clinical applications for the treatment of tumor cell metastasis.

  13. Parallel versus off-pathway Michaelis-Menten mechanism for single-enzyme kinetics of a fluctuating enzyme

    E-Print Network [OSTI]

    Kumar, Ashutosh; Dua, Arti

    2015-01-01T23:59:59.000Z

    Recent fluorescence spectroscopy measurements of the turnover time distribution of single-enzyme turnover kinetics of $\\beta$-galactosidase provide evidence of Michaelis-Menten kinetics at low substrate concentration. However, at high substrate concentrations, the dimensionless variance of the turnover time distribution shows systematic deviations from the Michaelis-Menten prediction. This difference is attributed to conformational fluctuations in both the enzyme and the enzyme-substrate complex and to the possibility of both parallel and off-pathway kinetics. Here, we use the chemical master equation to model the kinetics of a single fluctuating enzyme that can yield a product through either parallel or off-pathway mechanisms. An exact expression is obtained for the turnover time distribution from which the mean turnover time and randomness parameters are calculated. The parallel and off-pathway mechanisms yield strikingly different dependences of the mean turnover time and the randomness parameter on the su...

  14. LWRS Fuels Pathway: Engineering Design and Fuels Pathway Initial Testing of the Hot Water Corrosion System

    SciTech Connect (OSTI)

    Dr. John Garnier; Dr. Kevin McHugh

    2012-09-01T23:59:59.000Z

    The Advanced LWR Nuclear Fuel Development R&D pathway performs strategic research focused on cladding designs leading to improved reactor core economics and safety margins. The research performed is to demonstrate the nuclear fuel technology advancements while satisfying safety and regulatory limits. These goals are met through rigorous testing and analysis. The nuclear fuel technology developed will assist in moving existing nuclear fuel technology to an improved level that would not be practical by industry acting independently. Strategic mission goals are to improve the scientific knowledge basis for understanding and predicting fundamental nuclear fuel and cladding performance in nuclear power plants, and to apply this information in the development of high-performance, high burn-up fuels. These will result in improved safety, cladding, integrity, and nuclear fuel cycle economics. To achieve these goals various methods for non-irradiated characterization testing of advanced cladding systems are needed. One such new test system is the Hot Water Corrosion System (HWCS) designed to develop new data for cladding performance assessment and material behavior under simulated off-normal reactor conditions. The HWCS is capable of exposing prototype rodlets to heated, high velocity water at elevated pressure for long periods of time (days, weeks, months). Water chemistry (dissolved oxygen, conductivity and pH) is continuously monitored. In addition, internal rodlet heaters inserted into cladding tubes are used to evaluate repeated thermal stressing and heat transfer characteristics of the prototype rodlets. In summary, the HWCS provides rapid ex-reactor evaluation of cladding designs in normal (flowing hot water) and off-normal (induced cladding stress), enabling engineering and manufacturing improvements to cladding designs before initiation of the more expensive and time consuming in-reactor irradiation testing.

  15. Energy use by biological protein transport pathways

    E-Print Network [OSTI]

    Economou, Tassos

    Energy use by biological protein transport pathways Nathan N. Alder1 and Steven M. Theg2 1 of metabolic energy, using the free energy of ATP and GTP hydrolysis and/or a transmembrane protonmotive force provided insights into the mechanisms of energy transduction, force generation and energy use by different

  16. Disulfide-Linked Protein Folding Pathways

    E-Print Network [OSTI]

    Bardwell, James

    Disulfide-Linked Protein Folding Pathways Bharath S. Mamathambika1,3 and James C. Bardwell2,3, 1 of protein folding is difficult because it involves the identification and characterization of folding to protein folding in vitro and in vivo. 211 Click here for quick links to Annual Reviews content online

  17. Light Duty Vehicle Pathways July 26, 2010

    E-Print Network [OSTI]

    Light Duty Vehicle Pathways July 26, 2010 Sam Baldwin Chief Technology Officer Office of Energy Efficiency and Renewable Energy U.S. Department of Energy #12;2 Conventional Oil International Energy Agency #12;3 InterAcademy Panel Statement On Ocean Acidification, 1 June 2009 · Signed by the National

  18. Turbulence Investigation and Reproduction for Assisting Downstream Migrating Juvenile Salmonids, Part II of II; Effects of Induced Turbulence on Behavior of Juvenile Salmon, 2001-2005 Final Report.

    SciTech Connect (OSTI)

    Perry, Russell W.; Farley, M. Jared; Hansen, Gabriel S. (US Geological Survey, Western Fisheries Research Center, Columbia River Research Laboratory, Cook, WA)

    2005-07-01T23:59:59.000Z

    Passage through dams is a major source of mortality of anadromous juvenile salmonids because some populations must negotiate up to eight dams in Columbia and Snake rivers. Dams cause direct mortality when fish pass through turbines, but dams may also cause indirect mortality by altering migration conditions in rivers. Forebays immediately upstream of dams have decreased the water velocity of rivers and may contribute substantially to the total migration delay of juvenile salmonids. Recently, Coutant (2001a) suggested that in addition to low water velocities, lack of natural turbulence may contribute to migration delay by causing fish to lose directional cues. Coutant (2001a) further hypothesized that restoring turbulence in dam forebays may reduce migration delay by providing directional cues that allow fish to find passage routes more quickly (Coutant 2001a). Although field experiments have yielded proof of the concept of using induced turbulence to guide fish to safe passage routes, little is known about mechanisms actually causing behavioral changes. To test hypotheses about how turbulence influences movement and behavior of migrating juvenile salmonids, we conducted two types of controlled experiments at Cowlitz Falls Dam, Washington. A common measure of migration delay is the elapsed time between arrival at, and passage through, a dam. Therefore, for the first set of experiments, we tested the effect of induced turbulence on the elapsed time needed for fish to traverse through a raceway and pass over a weir at its downstream end (time trial experiment). If turbulence helps guide fish to passage routes, then fish should pass through the raceway quicker in the presence of appropriately scaled and directed turbulent cues. Second, little is known about how the physical properties of water movement provide directional cues to migrating juvenile salmonids. To examine the feasibility of guiding fish with turbulence, we tested whether directed turbulence could guide fish into one of two channels in the raceway, and subsequently cause them to pass disproportionately over the weir where turbulent cues were aimed (guidance experiment). Last, we measured and mapped water velocity and turbulence during the experiments to understand water movement patterns and the spatial distribution of turbulence in the raceways.

  19. A DC-81-indole conjugate agent suppresses melanoma A375 cell migration partially via interrupting VEGF production and stromal cell-derived factor-1{alpha}-mediated signaling

    SciTech Connect (OSTI)

    Hsieh, Ming-Chu [Graduate Institute of Pharmacy, Faculty of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan (China); Hu, Wan-Ping [Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung, Taiwan (China); Yu, Hsin-Su [Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (China); Wu, Wen-Chuan [Department of Ophthalmology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan (China); Chang, Long-Sen [Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan (China); Kao, Ying-Hsien, E-mail: danyhkao@gmail.com [Department of Medical Research, E-DA Hospital, I-Shou University, Kaohsiung, Taiwan (China); Wang, Jeh-Jeng, E-mail: jjwang@kmu.edu.tw [Graduate Institute of Pharmacy, Faculty of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan (China); Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan (China)

    2011-09-01T23:59:59.000Z

    Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) chemicals are antitumor antibiotics inhibiting nucleic acid synthesis. An indole carboxylate-PBD hybrid with six-carbon spacer structure (IN6CPBD) has been previously demonstrated to induce melanoma cell apoptosis and reduce metastasis in mouse lungs. This study aimed at investigating the efficacy of the other hybrid compound with four-carbon spacer (IN4CPBD) and elucidating its anti-metastatic mechanism. Human melanoma A375 cells with IN4CPBD treatment underwent cytotoxicity and apoptosis-associated assays. Transwell migration assay, Western blotting, and ELISA were used for mechanistic study. IN4CPBD exhibited potent melanoma cytotoxicity through interrupting G1/S cell cycle progression, increasing DNA fragmentation and hypodipoidic DNA contents, and reducing mitochondrial membrane potential. Caspase activity elevation suggested that both intrinsic and extrinsic pathways were involved in IN4CPBD-induced melanoma apoptosis. IN4CPBD up-regulated p53 and p21, thereby concomitantly derailing the equilibrium between Bcl-2 and Bax levels. Transwell migration assay demonstrated that stromal cell-derived factor-1{alpha} (SDF-1{alpha}) stimulated A375 cell motility, while kinase inhibitors treatment confirmed that Rho/ROCK, Akt, ERK1/2, and p38 MAPK pathways were involved in SDF-1{alpha}-enhanced melanoma migration. IN4CPBD not only abolished the SDF-1{alpha}-enhanced chemotactic motility but also suppressed constitutive MMP-9 and VEGF expression. Mechanistically, IN4CPBD down-regulated Akt, ERK1/2, and p38 MAPK total proteins and MYPT1 phosphorylation. In conclusion, beyond the fact that IN4CPBD induces melanoma cell apoptosis at cytotoxic dose, the interruption in the VEGF expression and the SDF-1{alpha}-related signaling at cytostatic dose may partially constitute the rationale for its in vivo anti-metastatic potency. - Research Highlights: > A novel carboxylate-PBD hybrid as anti-melanoma drug. > IN4CPBD interrupts melanoma cell cycle progression and induces apoptosis. > IN4CPBD suppresses SDF-1{alpha}-enhanced signaling and melanoma migration. > IN4CPBD abolishes angiogenic factor production and chemotactic effect of SDF-1{alpha}. > This drug is clinically applicable to melanoma therapy.

  20. Fusion Nuclear Science Pathways Assessment

    SciTech Connect (OSTI)

    C.E. Kessel, et. al.

    2012-02-23T23:59:59.000Z

    With the strong commitment of the US to the success of the ITER burning plasma mission, and the project overall, it is prudent to consider how to take the most advantage of this investment. The production of energy from fusion has been a long sought goal, and the subject of several programmatic investigations and time line proposals [1]. The nuclear aspects of fusion research have largely been avoided experimentally for practical reasons, resulting in a strong emphasis on plasma science. Meanwhile, ITER has brought into focus how the interface between the plasma and engineering/technology, presents the most challenging problems for design. In fact, this situation is becoming the rule and no longer the exception. ITER will demonstrate the deposition of 0.5 GW of neutron heating to the blanket, deliver a heat load of 10-20 MW/m2 or more on the divertor, inject 50-100 MW of heating power to the plasma, all at the expected size scale of a power plant. However, in spite of this, and a number of other technologies relevant power plant, ITER will provide a low neutron exposure compared to the levels expected to a fusion power plant, and will purchase its tritium entirely from world reserves accumulated from decades of CANDU reactor operations. Such a decision for ITER is technically well founded, allowing the use of conventional materials and water coolant, avoiding the thick tritium breeding blankets required for tritium self-sufficiency, and allowing the concentration on burning plasma and plasma-engineering interface issues. The neutron fluence experienced in ITER over its entire lifetime will be ~ 0.3 MW-yr/m2, while a fusion power plant is expected to experience 120-180 MW-yr/m2 over its lifetime. ITER utilizes shielding blanket modules, with no tritium breeding, except in test blanket modules (TBM) located in 3 ports on the midplane [2], which will provide early tests of the fusion nuclear environment with very low tritium production (a few g per year).

  1. Acoustic And Elastic Reverse-Time Migration: Novel Angle-Domain Imaging Conditions And Applications

    E-Print Network [OSTI]

    Yan, Rui

    2013-01-01T23:59:59.000Z

    imaging. For small angles, the PPP and PPS paths carry mosttraveling paths are labeled with two legs such as PPP-PSP.The left leg (PPP) is the downgoing path and the right leg (

  2. A matched-filter-based reverse-time migration algorithm for ground-penetrating radar data

    E-Print Network [OSTI]

    Leuschen, Carl; Plumb, R. G.

    2001-05-01T23:59:59.000Z

    , Binghamton, NY 13901 USA. Publisher Item Identifier S 0196-2892(01)04016-5. Fig. 1. Relationship between the object space and the three image spaces for GPR, where F and F denote temporal and spatial FTs, respectively. Spatial location and reflectivity... of producing an image. The main scope of this paper is to present a comprehensive development of a generalized 0196–2892/01$10.00 © 2001 IEEE 930 IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING, VOL. 39, NO. 5, MAY 2001 GPR imaging algorithm that is firmly...

  3. Acoustic And Elastic Reverse-Time Migration: Novel Angle-Domain Imaging Conditions And Applications

    E-Print Network [OSTI]

    Yan, Rui

    2013-01-01T23:59:59.000Z

    seismic properties of fractured reservoirs: 81th Annualproperties of a fractured reservoir (Zheng et al. , 3.6.2

  4. Timing Your Migration to XML There is no compelling reason to leave EDI

    E-Print Network [OSTI]

    to small and medium enterprises to the end-user creating XML documents in their word processor to locate the talented ones? Yes. The pervasiveness of XML in our environment has lead to improvements to the EDI environment? Up to a certain point. You can take the developments that arise in the XML world

  5. Acoustic And Elastic Reverse-Time Migration: Novel Angle-Domain Imaging Conditions And Applications

    E-Print Network [OSTI]

    Yan, Rui

    2013-01-01T23:59:59.000Z

    shale and the reservoir. We generate a synthetic data setshale and nine types of reservoirs are shown in Table 4.1. For this simple model, the seismic data

  6. The Determinants of Internal Migration in a Developing Country: Quantitative Evidence for Indonesia, 1930-200

    E-Print Network [OSTI]

    van Lottum, J; Marks, D

    1   The determinants of internal migration in a developing country: quantitative evidence for Indonesia, 1930-2000 J. van Lottuma* and D. Marksb a Cambridge Group for the History of Population and Social Structure, Geography Department... : Internal Migration; Indonesia; Gravity Model; Policy; Development JEL codes: J61; J68; N15; O15 Abstract This study specifies and estimates a gravity model for inter-provincial migration in Indonesia. Using panel data for Indonesia’s 26 provinces...

  7. Monitoring the Migrations of Wild Snake River Spring/Summer Chinook Salmon Juveniles, 2007-2008

    SciTech Connect (OSTI)

    Achord, Stephen; Sandford, Benjamin P.; Hockersmith, Eric E. [Fish Ecology Division, Northwest Fisheries Science Center

    2009-07-09T23:59:59.000Z

    This report provides results from an ongoing project to monitor the migration behavior and survival of wild juvenile spring/summer Chinook salmon in the Snake River Basin. Data reported is from detections of PIT tagged fish during late summer 2007 through mid-2008. Fish were tagged in summer 2007 by the National Marine Fisheries Service (NMFS) in Idaho and by the Oregon Department of Fish and Wildlife (ODFW) in Oregon. Our analyses include migration behavior and estimated survival of fish at instream PIT-tag monitors and arrival timing and estimated survival to Lower Granite Dam. Principal results from tagging and interrogation during 2007-2008 are: (1) In July and August 2007, we PIT tagged and released 7,390 wild Chinook salmon parr in 12 Idaho streams or sample areas. (2) Overall observed mortality from collection, handling, tagging, and after a 24-hour holding period was 1.4%. (3) Of the 2,524 Chinook salmon parr PIT tagged and released in Valley Creek in summer 2007, 218 (8.6%) were detected at two instream PIT-tag monitoring systems in lower Valley Creek from late summer 2007 to the following spring 2008. Of these, 71.6% were detected in late summer/fall, 11.9% in winter, and 16.5% in spring. Estimated parr-to-smolt survival to Lower Granite Dam was 15.5% for the late summer/fall group, 48.0% for the winter group, and 58.5% for the spring group. Based on detections at downstream dams, the overall efficiency of VC1 (upper) or VC2 (lower) Valley Creek monitors for detecting these fish was 21.1%. Using this VC1 or VC2 efficiency, an estimated 40.8% of all summer-tagged parr survived to move out of Valley Creek, and their estimated survival from that point to Lower Granite Dam was 26.5%. Overall estimated parr-to-smolt survival for all summer-tagged parr from this stream at the dam was 12.1%. Development and improvement of instream PIT-tag monitoring systems continued throughout 2007 and 2008. (4) Testing of PIT-tag antennas in lower Big Creek during 2007-2008 showed these antennas (and anchoring method) are not adequate to withstand high spring flows in this drainage. Future plans involve removing these antennas before high spring flows. (5) At Little Goose Dam in 2008, length and/or weight were taken on 505 recaptured fish from 12 Idaho stream populations. Fish had grown an average of 40.1 mm in length and 10.6 g in weight over an average of 288 d. Their mean condition factor declined from 1.25 at release (parr) to 1.05 at recapture (smolt). (6) Mean release lengths for detected fish were significantly larger than for fish not detected the following spring and summer (P < 0.0001). (7) Fish that migrated through Lower Granite Dam in April and May were significantly larger at release than fish that migrated after May (P < 0.0001) (only 12 fish migrated after May). (8) In 2008, peak detections at Lower Granite Dam of parr tagged during summer 2007 (from the 12 stream populations in Idaho and 4 streams in Oregon) occurred during moderate flows of 87.5 kcfs on 7 May and high flows of 197.3 kcfs on 20 May. The 10th, 50th, and 90th percentile passage occurred on 30 April, 11 May, and 23 May, respectively. (9) In 2007-2008, estimated parr-to-smolt survival to Lower Granite Dam for Idaho and Oregon streams (combined) averaged 19.4% (range 6.2-38.4% depending on stream of origin). In Idaho streams the estimated parr-to-smolt survival averaged 21.0%. This survival was the second highest since 1993 for Idaho streams. Relative parr densities were lower in 2007 (2.4 parr/100 m2) than in all previous years since 2000. In 2008, we observed low-to-moderate flows prior to mid-May and relatively cold weather conditions throughout the spring migration season. These conditions moved half of the fish through Lower Granite Dam prior to mid-May; then high flows moved 50 to 90% of the fish through the dam in only 12 days. Clearly, complex interrelationships of several factors drive the annual migrational timing of the stocks.

  8. NextSTEPS (Sustainable Transportation Energy Pathways) PROGRAM SUMMARY

    E-Print Network [OSTI]

    California at Davis, University of

    NextSTEPS (Sustainable Transportation Energy Pathways) PROGRAM SUMMARY Institute of Transportation in January 2011, building on the many advances of our Sustainable Transportation Energy Pathways (STEPS Studies University of California, Davis Automakers, energy companies, utilities and governments are making

  9. Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer

    E-Print Network [OSTI]

    Ooi, Chia Huey

    Many solid cancers are known to exhibit a high degree of heterogeneity in their deregulation of different oncogenic pathways. We sought to identify major oncogenic pathways in gastric cancer (GC) with significant relationships ...

  10. GERMANY AND THE UNITED STATES: SEARCHING FOR 21ST CENTURY MIGRATION POLICIES

    E-Print Network [OSTI]

    Martin, Philip L.

    1999-01-01T23:59:59.000Z

    and Foreign Workers in Germany, thousands Foreign ResidentsPast, Migration Future: Germany and the United States.International Considerations Germany and the United States

  11. assessing field-scale migration: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    de 6 Assessment of magic angle spinning spectroscopy for studying migration in solid milk chocolate MIT - DSpace Summary: In the confectionery industry, there is...

  12. Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice

    E-Print Network [OSTI]

    Britschgi, Markus; Takeda-Uchimura, Yoshiko; Rockenstein, Edward; Johns, Hudson; Masliah, Eliezer; Wyss-Coray, Tony

    2012-01-01T23:59:59.000Z

    et al. : Deficiency of terminal complement pathway inhibitorAccess Deficiency of terminal complement pathway inhibitoran inhibitor of the terminal complement pathway. Complement

  13. Pipelines, Pathways, and Payoffs: Economic Challenges and Returns to Changing Demographics in California

    E-Print Network [OSTI]

    Stiles, Jon; Brady, Henry

    2007-01-01T23:59:59.000Z

    on Multiple Pathways Pipelines, Pathways, and Payoffs:Jon Stiles & Henry Brady Pipelines, Pathways, and Payoffs:of the educational pipeline to describe how students

  14. Evolutionary outcomes for pairs of planets undergoing orbital migration and circularization: second order resonances and observed period ratios in Kepler's planetary systems

    E-Print Network [OSTI]

    Xiang-Gruess, M

    2015-01-01T23:59:59.000Z

    In order to study the origin of the architectures of low mass planetary systems, we perform numerical surveys of the evolution of pairs of coplanar planets in the mass range $(1-4)\\ \\rmn{M}_{\\oplus}.$ These evolve for up to $2\\times10^7 \\rmn{yr}$ under a range of orbital migration torques and circularization rates assumed to arise through interaction with a protoplanetary disc. Near the inner disc boundary, significant variations of viscosity, interaction with density waves or with the stellar magnetic field could occur and halt migration, but allow ircularization to continue. This was modelled by modifying the migration and circularization rates. Runs terminated without an extended period of circularization in the absence of migration torques gave rise to either a collision, or a system close to a resonance. These were mostly first order with a few $\\%$ terminating in second order resonances. Both planetary eccentricities were small $< 0.1$ and all resonant angles liberated. This type of survey produced o...

  15. alternative pathway activities: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    metabolism embodies Etxeberria, Edgardo 4 Questioning Inevitability of Energy Pathways: Alternative Energy Scenarios for California Renewable Energy Websites Summary: Questioning...

  16. An investigation of tendon sheathing filler migration into concrete

    SciTech Connect (OSTI)

    Naus, D.J.; Oland, C.B. [Oak Ridge National Lab., TN (United States)

    1998-03-01T23:59:59.000Z

    During some of the inspections at nuclear power plants with prestressed concrete containments, it was observed that the containments has experienced leakage of the tendon sheathing filler (i.e., streaks). The objective of this activity was to provide an indication of the extent of tendon sheathing filler leakage into the concrete and its affects on concrete properties. Literature was reviewed and concrete core samples were obtained from the Trojan Nuclear Plant and tested. The literature primarily addressed effects of crude or lubricating oils that are known to cause concrete damage. However, these materials have significantly different characteristics relative to the materials used as tendon sheathing fillers. Examination and testing of the concrete cores indicated that the appearance of tendon sheathing filler on the concrete surface was due to leakage from the conduits and its subsequent migration through cracks that were present. Migration of the tendon sheathing filler was confined to the cracks and there was no perceptible movement into the concrete. Results of compressive strength testing indicated that the concrete quality was consistent in the containment and that the strength had increased over 40% in 25.4 years relative to the average compressive strength at 28-days age.

  17. Genome Comparisons Based on Profiles of Metabolic Pathways

    E-Print Network [OSTI]

    Liao, Li

    Genome Comparisons Based on Profiles of Metabolic Pathways Li Liao1, , Sun Kim2 , Jean and absence of the various metabolic pathways, and constitute the basis for a comparison of organisms, as applied to analyzing fully sequenced genomes, can shed light on evolution of metabolic pathways. 1

  18. Development of a Clinical Pathways Analysis System with Adaptive Bayesian

    E-Print Network [OSTI]

    Kopec, Danny

    Development of a Clinical Pathways Analysis System with Adaptive Bayesian Nets and Data Mining such analyses. The computation of "lift" (a measure of completed pathways improvement potential) leads us an artificial set of such records and use these for clinical pathways analyses. We use data mining software

  19. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS PART 4: POLICY AND SUSTAINABLE TRANSPORTATION Part 4: Policy and pollutants such as aerosols and black carbon. Third, more #12;250 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS

  20. DYNAMIC INVARIANTS IN PROTEIN FOLDING PATHWAYS REVEALED BY TENSOR ANALYSIS

    E-Print Network [OSTI]

    Langmead, Christopher James

    DYNAMIC INVARIANTS IN PROTEIN FOLDING PATHWAYS REVEALED BY TENSOR ANALYSIS Arvind Ramanathan Lane a spatio-temporal analysis of protein folding pathways. We applied our method to folding simulations of how a protein folds into its functionally relevant conformations. Protein folding pathways span over

  1. Modeling Protein Folding Pathways Christopher Bystroff, Yu Shao

    E-Print Network [OSTI]

    Bystroff, Chris

    Modeling Protein Folding Pathways Christopher Bystroff, Yu Shao Dept of Biology Rensselaer Polytechnic Institute, Troy, NY. e-mail:{bystrc, shaoy}@rpi.edu Summary Proteins fold through a series of intermediate states called a pathway. Protein folding pathways have been modeled using either simulations

  2. Emissions pathways, climate change, and impacts on California

    E-Print Network [OSTI]

    Kammen, Daniel M.

    Emissions pathways, climate change, and impacts on California Katharine Hayhoea,b , Daniel Cayanc emission pathways we choose. Here we explore the implications of the highest and lowest Intergovern- mental Panel on Climate Change emissions pathways for climate change and associated impacts in California

  3. Assessment of heterologous butyrate and butanol pathway activity by measurement of intracellular pathway intermediates in recombinant Escherichia coli

    E-Print Network [OSTI]

    Fischer, Curt R.; Tseng, Hsien-Chung; Tai, Mitchell; Prather, Kristala L.; Stephanopoulos, Gregory

    2010-01-01T23:59:59.000Z

    design and engineering of metabolic pathways for the bioconversion of various feedstocks to desired fuels and chemicals.

  4. Pathways, Networks and Systems Medicine Conferences

    SciTech Connect (OSTI)

    Nadeau, Joseph H. [Pacific Northwest Research Institute] [Pacific Northwest Research Institute

    2013-11-25T23:59:59.000Z

    The 6th Pathways, Networks and Systems Medicine Conference was held at the Minoa Palace Conference Center, Chania, Crete, Greece (16-21 June 2008). The Organizing Committee was composed of Joe Nadeau (CWRU, Cleveland), Rudi Balling (German Research Centre, Brauschweig), David Galas (Institute for Systems Biology, Seattle), Lee Hood (Institute for Systems Biology, Seattle), Diane Isonaka (Seattle), Fotis Kafatos (Imperial College, London), John Lambris (Univ. Pennsylvania, Philadelphia),Harris Lewin (Univ. of Indiana, Urbana-Champaign), Edison Liu (Genome Institute of Singapore, Singapore), and Shankar Subramaniam (Univ. California, San Diego). A total of 101 individuals from 21 countries participated in the conference: USA (48), Canada (5), France (5), Austria (4), Germany (3), Italy (3), UK (3), Greece (2), New Zealand (2), Singapore (2), Argentina (1), Australia (1), Cuba (1), Denmark (1), Japan (1), Mexico (1), Netherlands (1), Spain (1), Sweden (1), Switzerland (1). With respect to speakers, 29 were established faculty members and 13 were graduate students or postdoctoral fellows. With respect to gender representation, among speakers, 13 were female and 28 were male, and among all participants 43 were female and 58 were male. Program these included the following topics: Cancer Pathways and Networks (Day 1), Metabolic Disease Networks (Day 2), Day 3 ? Organs, Pathways and Stem Cells (Day 3), and Day 4 ? Inflammation, Immunity, Microbes and the Environment (Day 4). Proceedings of the Conference were not published.

  5. SPECIAL ANALYSIS AIR PATHWAY MODELING OF E-AREA LOW-LEVEL WASTE FACILITY

    SciTech Connect (OSTI)

    Hiergesell, R.; Taylor, G.

    2011-08-30T23:59:59.000Z

    This Special Analysis (SA) was initiated to address a concern expressed by the Department of Energy's Low Level Waste Disposal Facility Federal Review Group (LFRG) Review Team during their review of the 2008 E-Area Performance Assessment (PA) (WSRC, 2008). Their concern was the potential for overlapping of atmospheric plumes, emanating from the soil surface above SRS LLW disposal facilities within the E-Area, to contribute to the dose received by a member of the public during the Institutional Control (IC) period. The implication of this concern was that the dose to the maximally-exposed individual (MEI) located at the SRS boundary might be underestimated during this time interval. To address this concern a re-analysis of the atmospheric pathway releases from E-Area was required. In the process of developing a new atmospheric release model (ARM) capable of addressing the LFRG plume overlap concern, it became obvious that new and better atmospheric pathway disposal limits should be developed for each of the E-Area disposal facilities using the new ARM. The scope of the SA was therefore expanded to include the generation of these new limits. The initial work conducted in this SA was to develop a new ARM using the GoldSim{reg_sign} program (GTG, 2009). The model simulates the subsurface vapor diffusion of volatile radionuclides as they release from E-Area disposal facility waste zones and migrate to the land surface. In the process of this work, many new features, including several new physical and chemical transport mechanisms, were incorporated into the model. One of the most important improvements was to incorporate a mechanism to partition volatile contaminants across the water-air interface within the partially saturated pore space of the engineered and natural materials through which vapor phase transport occurs. A second mechanism that was equally important was to incorporate a maximum concentration of 1.9E-07 Ci/m{sup 3} of {sup 14}CO{sub 2} in the air-filled pores of cementitious materials. The ARM also combines the individual transport models constructed for each E-Area disposal facility into a single model, and was ultimately used to analyze the LFRG concern regarding the potential for atmospheric plume overlap at the SRS boundary during the IC period. To evaluate the plume overlap issue, a conservative approach was adopted whereby the MEI at the SRS boundary was exposed to the releases from all E-Area disposal facilities simultaneously. This is equivalent to a 100% overlap of all atmospheric plumes emanating from E-Area. Should the dose received from this level of atmospheric plume overlap still fall below the permissible exposure level of 10 mrem/yr, then the LFRG concern would be alleviated. The structuring of the ARM enables this evaluation to be easily performed. During the IC period, the peak of the 'total plume overlap dose' was computed to be 1.9E-05 mrem/yr, which is five orders of magnitude lower than the 10 mrem/yr PA performance objective for the atmospheric release pathway. The main conclusion of this study is that for atmospheric releases from the E-Area disposal facilities, plume overlap does not cause the total dose to the MEI at the SRS boundary during the IC to exceed the Performance Assessment (PA) performance objective. Additionally, the potential for plume overlap was assessed in the post-Institutional Control period. Atmospheric plume overlap is less likely to occur during this period but conceivably could occur if the prevailing wind direction shifted so as to pass directly over all EArea disposal facilities and transport airborne radionuclides to the MEI at the 100 m point of compliance (POC). This concern was also demonstrated of little concern, as the maximum plume overlap dose was found to be 1.45E+00 mrem/yr (or {approx}15% of the performance measure) during this period and under these unlikely conditions.

  6. Autocrine EGF receptor activation mediates endothelial cell migration and vascular morphogenesis induced by VEGF under interstitial flow

    SciTech Connect (OSTI)

    Semino, Carlos E. [Center for Biomedical Engineering and Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, NE47-383, MIT, Cambridge, MA 02139 (United States)]. E-mail: semino@mit.edu; Kamm, Roger D. [Center for Biomedical Engineering and Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, NE47-383, MIT, Cambridge, MA 02139 (United States); Lauffenburger, Douglas A. [Center for Biomedical Engineering and Biological Engineering Division, Massachusetts Institute of Technology, 77 Massachusetts Avenue, NE47-383, MIT, Cambridge, MA 02139 (United States)

    2006-02-01T23:59:59.000Z

    We show here that autocrine ligand activation of epidermal growth factor (EGF) receptor in combination with interstitial flow is critically involved in the morphogenetic response of endothelial cells to VEGF stimulation. Human umbilical vein endothelial cell (HUVEC) monolayers cultured on a collagen gel and exposed to low interstitial flow in the absence of EGF and VEGF remained viable and mitotic but exhibited little evidence of vascular morphogenesis. Addition of VEGF produced a flow-dependent morphogenetic response within 48 to 72 h, characterized by branched capillary-like structures. The response was substantially abolished by inhibitors related to the autocrine EGF receptor pathway including Galardin, AG1478, PD98059, and an EGF receptor-blocking antibody, indicating that regulation of the morphogenetic process operates via autocrine EGF receptor activation. Moreover, we observed that in our system the EGF receptor was always activated independently of the interstitial flow, and, in addition, the EGF receptor inhibitors used above reduced the phosphorylation state of the receptor, correlating with inhibition of capillary morphogenesis. Finally, 5'bromo-2'-deoxyuridine (BrdU) labeling identified dividing cells at the monolayer but not in the extending capillary-like structures. EGF pathway inhibitors Galardin and AG1478 did not reduce BrdU incorporation in the monolayer, indicating that the EGF-receptor-mediated morphogenetic behavior is mainly due to cell migration rather than proliferation. Based on these results, we propose a two-step model for in vitro capillary morphogenesis in response to VEGF stimulation with interstitial fluid flow: monolayer maintenance by mitotic activity independent of EGF receptors and a migratory response mediated by autocrine EGF receptor activation wherein cells establish capillary-like structures.

  7. New pathway to bypass the 15O waiting point

    E-Print Network [OSTI]

    I. Stefan; F. de Oliveira Santos; M. G. Pellegriti; G. Dumitru; J. C. Angélique; M. Angélique; E. Berthoumieux; A. Buta; R. Borcea; A. Coc; J. M. Daugas; T. Davinson; M. Fadil; S. Grévy; J. Kiener; A. Lefebvre-Schuhl; M. Lenhardt; M. Lewitowicz; F. Negoita; D. Pantelica; L. Perrot; O. Roig; M. G. Saint Laurent; I. Ray; O. Sorlin; M. Stanoiu; C. Stodel; V. Tatischeff; J. C. Thomas

    2006-04-14T23:59:59.000Z

    We propose the sequential reaction process $^{15}$O($p$,$\\gamma)(\\beta^{+}$)$^{16}$O as a new pathway to bypass of the $^{15}$O waiting point. This exotic reaction is found to have a surprisingly high cross section, approximately 10$^{10}$ times higher than the $^{15}$O($p$,$\\beta^{+}$)$^{16}$O. These cross sections were calculated after precise measurements of energies and widths of the proton-unbound $^{16}$F low lying states, obtained using the H($^{15}$O,p)$^{15}$O reaction. The large $(p,\\gamma)(\\beta^{+})$ cross section can be understood to arise from the more efficient feeding of the low energy wing of the ground state resonance by the gamma decay. The implications of the new reaction in novae explosions and X-ray bursts are discussed.

  8. Single-enzyme kinetics with branched pathways: exact theory and series expansion

    E-Print Network [OSTI]

    Ashok Garai; Debashish Chowdhury

    2014-12-10T23:59:59.000Z

    The progress of the successive rounds of catalytic conversion of substrates into product(s) by a single enzyme is characterized by the distribution of turnover times. Establishing the most general form of dependence of this distribution on the substrate concentration [S] is one of the fundamental challenges in single molecule enzymology. The distribution of the times of dwell of a molecular motor at the successive positions on its track is an analogous quantity. We derive approximate series expansions for the [ATP]-dependence of the first two moments of the dwell time distributions of motors that catalyze hydrolysis of ATP to draw input energy. Comparison between our results for motors with branched pathways and the corresponding expressions reported earlier for linear enzymatic pathways provides deep insight into the effects of the branches. Such insight is likely to help in discovering the most general form of [S]-dependence of these fundamental distributions.

  9. Interregional Migration in Germany: Characteristics and Effects for Regions and Migrants

    E-Print Network [OSTI]

    Pfeifer, Holger

    Interregional Migration in Germany: Characteristics and Effects for Regions and Migrants Christian of economic activity in East Germany initiated enormous migration flows from East to West Germany. People from East Germany moved towards West Germany, where wages are higher and em- ployment opportunities are more

  10. Gas Migration from Closed Coal Mines to the Surface RISK ASSESSMENT METHODOLOGY AND PREVENTION MEANS

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Gas Migration from Closed Coal Mines to the Surface RISK ASSESSMENT METHODOLOGY AND PREVENTION to the surface is especially significant in the context of coal mines. This is because mine gas can migrate of the scheduled closure of all coal mining operations in France, INERIS has drawn up, at the request of national

  11. The impact of floating migration on fertility in China: are floating migrants "childbearing guerillas"?

    E-Print Network [OSTI]

    You, Xiuhong

    2002-01-01T23:59:59.000Z

    of the country on the fertility/migration issue. A three-step analysis containing a series of Poisson regression models is conducted and existing migration/fertility theories are used to explain the results of the analysis. Floating migrants are defined as those...

  12. MODEL OF THE .MIGRATION OF ALBACORE IN THE NORTH PACIFIC OCEAN

    E-Print Network [OSTI]

    MODEL OF THE .MIGRATION OF ALBACORE IN THE NORTH PACIFIC OCEAN .By TAMIO OTSU and RICHARD N. UCHIDA of the migration of albacore in the North Pacific Ocean has been developed. This model is consistent with the hypothesis that there is a single population of albacore in the North Pacific Ocean. . The model depicts

  13. Migration and bioenergetics of juvenile Snake River fall Chinook salmon Daniel Widener

    E-Print Network [OSTI]

    Washington at Seattle, University of

    Migration and bioenergetics of juvenile Snake River fall Chinook salmon Daniel Widener A thesis: Aquatic and Fishery Sciences #12;#12;University of Washington Abstract Migration and Bioenergetics are still poorly understood. This thesis describes a complex of individually-based bioenergetic

  14. Acoustic and Thermal Characterization of Oil Migration, Gas Hydrates Formation and Silica Diagenesis

    E-Print Network [OSTI]

    Guerin, Gilles

    Rights Reserved #12;ABSTRACT Acoustic and Thermal Characterization of Oil Migration, Gas HydratesAcoustic and Thermal Characterization of Oil Migration, Gas Hydrates Formation and Silica is applied to two reservoirs in the Gulf of Mexico. In the last chapter, we present the thermal regime

  15. Duffy et al.: Arctic Tern migration over Patagonia 155 Marine Ornithology 41: 155159 (2013)

    E-Print Network [OSTI]

    Duffy, David Cameron

    Duffy et al.: Arctic Tern migration over Patagonia 155 Marine Ornithology 41: 155­159 (2013 productive offshore waters of Argentinian Patagonia. We then explore possible reasons for this behavior-ANDEAN PASSAGE OF MIGRATING ARCTIC TERNS OVER PATAGONIA DAVID CAMERON DUFFY1 , ALY MCKNIGHT2 & DAVID B. IRONS2 1

  16. R-Ras Regulates Migration through an Interaction with Filamin A in Melanoma Cells

    E-Print Network [OSTI]

    Ramos, Joe W.

    R-Ras Regulates Migration through an Interaction with Filamin A in Melanoma Cells Joanna E. Gawecka and b7 tails and is associated with diverse cell processes including cell migration. Indeed, M2 melanoma melanoma cells active R-Ras co-localized with FLNa but did not co-localize with FLNa lacking repeat 3. Thus

  17. MDE and Mobile agents: another reflection on the agent migration Tahar GHERBI

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    code. Mobile agents are a very interesting technology to develop applications for mobile introduces MDE. Section 3 presents the mobile-agent technology, describes the migration operationMDE and Mobile agents: another reflection on the agent migration Tahar GHERBI Computer science

  18. RURAL-FRONTIER MIGRATION AND DEFORESTATION IN THE SIERRA DE LACANDON NATIONAL PARK, GUATEMALA

    E-Print Network [OSTI]

    Lopez-Carr, David

    RURAL-FRONTIER MIGRATION AND DEFORESTATION IN THE SIERRA DE LACANDON NATIONAL PARK, GUATEMALA-frontier Migration and Deforestation in the Sierra de Lacandón National Park, Guatemala (Under the direction of deforestation in the Sierra de Lacandón Park (SLNP), Petén, Guatemala. To explore the first cause

  19. Oklahoma, Maine, Migration and "Right to Work": A Confused and Misleading Analysis

    E-Print Network [OSTI]

    Thomas, Andrew

    Oklahoma, Maine, Migration and "Right to Work": A Confused and Misleading Analysis By the Bureau Policy Center (MHPC), "The Case for Right-to-Work in Maine: Examining the Evidence in Oklahoma" (1 the case of Oklahoma's RTW law, and then presenting a number of statistics on migration to Oklahoma

  20. Testing Oil Saturation Distribution in Migration Paths Using MRI1 Jianzhao Yan 1

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    - 1 - Testing Oil Saturation Distribution in Migration Paths Using MRI1 Jianzhao Yan 1 , Xiaorong media, and to measure oil and water saturation. Although this technique has great advantages compared14. Using15 MRI, the oil secondary migration paths are scanned to measure the saturation distribution during

  1. Improving Data Locality Using Dynamic Page Migration based on Memory Access Histograms

    E-Print Network [OSTI]

    Stamatakis, Alexandros

    Improving Data Locality Using Dynamic Page Migration based on Memory Access Histograms Jie Tao user­level page migration. It uses memory access histograms gathered by hardware monitors to make applications show the potential for a significant gain in speedup. In addition, a graphical user inter­ face

  2. Anaerobic Migrating Blanket Reactor Treatment of Low-Strength Wastewater at

    E-Print Network [OSTI]

    Angenent, Lars T.

    Anaerobic Migrating Blanket Reactor Treatment of Low-Strength Wastewater at Low Temperatures Largus anaerobic migrating blanket reactor (AMBR) was studied for the treatment of low- strength soluble wastewater). KEYWORDS: anaerobic treatment, low-strength wastewater, low-tem- perature conditions, compartmentalized

  3. Process Instance Migration: Flexible Execution of Distributed Business Processes Kristof Hamann, Sonja Zaplata, Winfried Lamersdorf

    E-Print Network [OSTI]

    Hamburg.Universität

    Process Instance Migration: Flexible Execution of Distributed Business Processes Kristof Hamann on process instance migration. It includes corresponding results in the context of dynamic and mobile environments (as, e.g., provided by mobile web services, NFC- aware process execution, future

  4. Migration of 1970s Minicomputer Controls to Modern Toolkit Software

    SciTech Connect (OSTI)

    Juras, R.C.; Meigs, M.J.; Sinclair, J.A.; Tatum, B.A.

    1999-11-13T23:59:59.000Z

    Controls for accelerators and associated systems at the Holifield Radioactive Ion Beam Facility (HRIBF) at Oak Ridge National Laboratory have been migrated from 197Os-vintage minicomputers to a modern system based on Vista and EPICS toolkit software. Stability and capabilities of EPICS software have motivated increasing use of EPICS for accelerator controls. In addition, very inexpensive subsystems based on EPICS and the EPICS portable CA server running on Linux PCs have been implemented to control an ion source test facility and to control a building-access badge reader system. A new object-oriented, extensible display manager has been developed for EPICS to facilitate the transition to EPICS and will be used in place of MEDM. EPICS device support has been developed for CAMAC serial highway controls.

  5. Contamination of shallow wells in Nigeria from surface contaminant migration

    SciTech Connect (OSTI)

    Ademoroti, C.M.A. (Univ. of Benin (Nigeria))

    1987-01-01T23:59:59.000Z

    Contaminated wells, located in six south/western and western states of Nigeria, were sampled and analyzed for pollution characteristics. Results of analysis indicated migration of contaminants into the wells from places where there was a potential source. There was a significant microbiological population in the wells placed near domestic waste sites. Also, there were excessive levels of trace heavy metals in those placed near metal dumping sites. On the other hand, the contaminants were minimal in wells that were not close to polluting sources. The studies revealed that groundwater contamination occurred primarily by dumping of wastes, wrong placement of waste disposal facilities, and improper construction of wells. The groundwater sources (wells, etc.) are used when pipe-borne water facilities are inadequate.

  6. Influence of soil biopopulation on migration of waste radionuclides

    SciTech Connect (OSTI)

    Fowler, E.B.; Polzer, W.L.; Essington, E.H.

    1983-01-01T23:59:59.000Z

    This paper reports the interpretation of some results obtained when a Maxey Flats burial pit radioactive waste solution was reacted with a Tilsit soil. The influence of a biopopulation on the degree of sorption and on the stability of that system was investigated. The data have been interpreted as follows: the removal of /sup 137/Cs from solution by the soil is essentially complete within a one-hour period and is not influenced by an active biopopulation. The soil studied contains complexers which solublize /sup 238/Pu. The soluble complex does not sorb to soil and thus is potentially mobile. In the presence of an active biopopulation 86% of the complexes is degraded; the released /sup 238/Pu was rendered immobile. The remaining 14% of the soluble /sup 238/Pu was not released to the soil during 53 days incubation. That fraction is heat stable and non- or slowly-biodegradable and thus retains its potential to migrate.

  7. The role of drebrin in glioma migration and invasion

    SciTech Connect (OSTI)

    Terakawa, Yuzo [The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario (Canada); Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka (Japan); Agnihotri, Sameer; Golbourn, Brian; Nadi, Mustafa; Sabha, Nesrin; Smith, Christian A. [The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario (Canada); Croul, Sidney E. [The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario (Canada); Division of Neuropathology, University Health Network, Department of Laboratory Medicine and Pathobiology (Canada); Rutka, James T., E-mail: james.rutka@sickkids.ca [The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario (Canada); Department of Surgery, University of Toronto, Toronto, Ontario (Canada)

    2013-02-15T23:59:59.000Z

    Glioblastoma (GBM) is the most common primary brain tumor in adults. Despite current advances in therapy consisting of surgery followed by chemotherapy and radiation, the overall survival rate still remains poor. Therapeutic failures are partly attributable to the highly infiltrative nature of tumor adjacent to normal brain parenchyma. Recently, evidence is mounting to suggest that actin cytoskeleton dynamics are critical components of the cell invasion process. Drebrin is an actin-binding protein involved in the regulation of actin filament organization, and plays a significant role in cell motility; however, the role of drebrin in glioma cell invasiveness has not yet been fully elucidated. Therefore, this study was aimed to clarify the role of drebrin in glioma cell morphology and cell motility. Here we show that drebrin is expressed in glioma cell lines and in operative specimens of GBM. We demonstrate that stable overexpression of drebrin in U87 cells leads to alterations in cell morphology, and induces increased invasiveness in vitro while knockdown of drebrin in U87 cells by small interfering RNA (siRNA) decreases invasion and migration. In addition, we show that depletion of drebrin by siRNA alters glioma cell morphology in A172 GBM cell line. Our results suggest that drebrin contributes to the maintenance of cell shape, and may play an important role in glioma cell motility. - Highlights: ? Drebrin is an actin-binding protein aberrantly expressed in several cancers. ? Role of drebrin in glioma cell morphology and motility is previously unknown. ? We demonstrate that drebrin is expressed in 40% of glioblastoma specimens. ? Drebrin plays a significant role in modulating glioma cell migration and invasion.

  8. 2D protrusion but not motility predicts growth factor–induced cancer cell migration in 3D collagen

    E-Print Network [OSTI]

    Meyer, Aaron Samuel

    Growth factor–induced migration is a critical step in the dissemination and metastasis of solid tumors. Although differences in properties characterizing cell migration on two-dimensional (2D) substrata versus within ...

  9. Alekwu Poetry as a Source of Historical Reconstruction: The Pursuit of Idoma-Otukpo Origin, Genealogy and Migration

    E-Print Network [OSTI]

    Amali, Idris O.O.

    1997-01-01T23:59:59.000Z

    of Idoma-Otukpo Origin, Genealogy and Migration Idris 0. 0.investigation into the origin, genealogy and migration ofhistory of the land, the genealogies of the lineages and the

  10. From aspirations to “dream-trap”: nurse education in Nepal and Nepali nurse migration to the UK 

    E-Print Network [OSTI]

    Adhikari, Radha

    2011-11-25T23:59:59.000Z

    The migration of nurses is stimulating international debate around globalisation, ethics, and the effects on health systems. This thesis examines this phenomenon through nurses trained in Nepal who migrate to the UK. ...

  11. On the gap-opening criterion of migrating planets in protoplanetary disks

    E-Print Network [OSTI]

    Malik, Matej; Mayer, Lucio; Meyer, Michael R

    2015-01-01T23:59:59.000Z

    We perform two-dimensional hydrodynamical simulations to quantitatively explore the torque balance criterion for gap-opening (as formulated by Crida et al. 2006) in a variety of disks when considering a migrating planet. We find that even when the criterion is satisfied, there are instances when planets still do not open gaps. We stress that gap-opening is not only dependent on whether a planet has the ability to open a gap, but whether it can do so quickly enough. This can be expressed as an additional condition on the gap-opening timescale versus the crossing time, i.e. the time it takes the planet to cross the region which it is carving out. While this point has been briefly made in the previous literature, our results quantify it for a range of protoplanetary disk properties and planetary masses, demonstrating how crucial it is for gap-opening. This additional condition has important implications for the survival of planets formed by core accretion in low mass disks as well as giant planets or brown dwarf...

  12. Electrohydrodynamic migration of a spherical drop in a general quadratic flow

    E-Print Network [OSTI]

    Mandal, Shubhadeep; Chakraborty, Suman

    2015-01-01T23:59:59.000Z

    We investigate the motion of a spherical drop in a general quadratic flow acted upon by an arbitrarily oriented externally applied uniform electric field. The drop and media are considered to be leaky dielectrics. The flow field affects the distribution of charges on the drop surface, which leads to alteration in the electric field, thereby affecting the velocity field through the Maxwell stress on the fluid-fluid interface. The two-way coupled electrohydrodynamics is central towards dictating the motion of the drop in the flow field. We analytically address the electric potential distribution and Stokesian flow field in and around the drop in a general quadratic flow for small electric Reynolds number (which is the ratio of the charge relaxation time scale to the convective time scale). As a special case, we consider a drop in an unbounded cylindrical Poiseuille flow and show that, an otherwise absent, cross-stream drop migration may be obtained in the presence of a uniform electric field. Depending on the d...

  13. Targeting Young Stars with Kepler: Planet Formation, Migration Mechanisms and the Early History of Planetary Systems

    E-Print Network [OSTI]

    Lloyd, James P; Mamajek, Eric; Spiegel, David S; Covey, Kevin R; Shkolnik, Evgenya L; Walkowicz, Lucianne; Chavez, Miguel; Bertone, Emanuele; Aguilar, Jose Manuel Olmedo

    2013-01-01T23:59:59.000Z

    This white paper discusses a repurposed mission for the Kepler spacecraft that focusses on solving outstanding problems in planet formation and evolution by targeting the study of the hot Jupiter population of young stars. This mission can solve the question of the mode of migration of hot Jupiters, address the problem of whether Jupiters form by hot-start (gravitational instability) or cold-start (core accretion) mechanisms, and provide a wealth of data on the early stages of planetary system evolution during the active phases of stars which impact planetary habitability. In one year of observations of three weeks dwell time per field, Kepler would increase by more than an order of magnitude the number of known hot Jupiters, which can be followed up with fast cadence observations to to search for transit timing variations and to perform asteroseismological characterization of the host stars. This mission scenario continues to operate Kepler in the photometric monitoring mode for which it was designed, and is...

  14. Serpentinization reaction pathways: implications for modeling approach

    SciTech Connect (OSTI)

    Janecky, D.R.

    1986-01-01T23:59:59.000Z

    Experimental seawater-peridotite reaction pathways to form serpentinites at 300/sup 0/C, 500 bars, can be accurately modeled using the EQ3/6 codes in conjunction with thermodynamic and kinetic data from the literature and unpublished compilations. These models provide both confirmation of experimental interpretations and more detailed insight into hydrothermal reaction processes within the oceanic crust. The accuracy of these models depends on careful evaluation of the aqueous speciation model, use of mineral compositions that closely reproduce compositions in the experiments, and definition of realistic reactive components in terms of composition, thermodynamic data, and reaction rates.

  15. Pathways for Algal Biofuels | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdfBreaking ofOilNEWResponse(Expired) |CERCLA ProcessDepartmentPast STARTPathwayPathways

  16. Solar Market Pathways | Department of Energy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently AskedEnergyIssues DOE's Nuclear EnergySmart Metersof Energy LEDMarket Pathways

  17. China 2050 Pathways Calculator | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual Siteof EnergyInnovation inOpenadd: ChinaInformationChestnutCountries2050 Pathways

  18. Technology Pathway Selection Effort | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdfBreakingMayDepartment ofEnergyTeamDevelopment Advances EMTechnology Pathway

  19. Hydrogen Pathway Cost Distributions | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e&Funding andMaterialPathway Cost

  20. Preliminary conceptual study on impact of land reclamation on groundwater flow and contaminant migration in Penny's Bay

    E-Print Network [OSTI]

    Jiao, Jiu Jimmy

    but will migrate northeast toward Yam O Wan. FEMWATER, a three-dimensional finite element ground water model

  1. Return Migrations, Assimilation, and Cultural Adaptations among Mexican American Professionals from the Lower Rio Grande Valley of South Texas

    E-Print Network [OSTI]

    Garcia, Jesus Alberto

    2012-07-16T23:59:59.000Z

    RETURN MIGRATIONS, ASSIMILATION, AND CULTURAL ADAPTATIONS AMONG MEXICAN AMERICAN PROFESSIONALS FROM THE LOWER RIO GRANDE VALLEY OF SOUTH TEXAS A Dissertation by JESUS ALBERTO GARCIA Submitted... Migrations, Assimilation, and Cultural Adaptations among Mexican American Professionals from the Lower Rio Grande Valley of South Texas Copyright 2011 Jesus Alberto Garcia RETURN MIGRATIONS, ASSIMILATION, AND CULTURAL ADAPTATIONS AMONG...

  2. Journals migrating platforms in May 2012 Please plan ahead for Annals of Internal Medicine and JAMA & Archives.

    E-Print Network [OSTI]

    Kim, Duck O.

    Journals migrating platforms in May 2012 ­ Please plan ahead for Annals of Internal Medicine and JAMA & Archives. Several ejournals are migrating platforms in May 2012, and as with all platform will migrate away from Highwire Press and move to Silverchair. The new URL to connect to the new platform

  3. Centrifuge modeling of radioactive waste migration through backfill in a near surface disposal facility

    SciTech Connect (OSTI)

    Gurumoorthy, C.; Kusakabe, O. [Geotechnical Engineering Division, Tokyo Institute of Technology, 2-12-1 Ookayama Meguroku, Tokyo 1528552 (Japan)

    2007-07-01T23:59:59.000Z

    Investigations on the performance of backfill barrier in Near Surface Disposal Facility (NSDF) for radioactive wastes are important to ensure the long term safety of such disposal option. Favorable condition to delay migration of radionuclides from disposed waste to far fields is diffusion process. However, advective dispersion/diffusion mechanism plays an important role due to changes in backfill over a period of time. In order to understand these mechanisms, detailed laboratory experiments are usually conducted for developing mathematical models to assess the behaviour of backfill. However, these experiments are time consuming and suffer with the limitations due to material complexity. Also, there are constraints associated with validation of theoretical predictions due to intricacy of boundary conditions as well as the time scale is quite different as compared to the time required for completion of the processes in the field. Keeping in view these aspects, centrifuge modeling technique has been adopted by various researchers to model and understand various geo-environment problems in order to provide a link between the real life situation termed as the 'Prototype' and its model, which is exposed to a higher gravitational field. An attempt has been made in this paper to investigate the feasibility of this technique to model advective dispersion/diffusion mechanism of radionuclides through saturated Bentonite-Sand (B:S) backfill. Various stages of centrifuge modeling are highlighted. Column tests were conducted in the centrifuge to evaluate the hydraulic conductivity of B:S mixture under prototype NSDF stress conditions. Results showed that steady state hydraulic conductivity under saturated conditions was 2.86 10{sup -11} m/sec. Studies indicate the feasibility of centrifuge modeling technique and usefulness to model advective diffusion of radionuclides through B:S backfill. (authors)

  4. miR-196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells

    SciTech Connect (OSTI)

    Zhang, Jie [Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000 (China)] [Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000 (China); Zheng, Fangxia [Department of Radiotherapy, Liaocheng People’s Hospital, Liaocheng 252000 (China)] [Department of Radiotherapy, Liaocheng People’s Hospital, Liaocheng 252000 (China); Yu, Gang [Department for Disease Control, Tumor Hospital of Liaocheng, Liaocheng 252000 (China)] [Department for Disease Control, Tumor Hospital of Liaocheng, Liaocheng 252000 (China); Yin, Yanhua, E-mail: yinyanhuablk@163.com [Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000 (China)] [Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000 (China); Lu, Qingyang [Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000 (China)] [Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000 (China)

    2013-11-01T23:59:59.000Z

    Highlights: •miR-196a was overexpressed in cervical cancer tissue compared to normal tissue. •miR-196a expression elevated proliferation and migration of cervical cancer cells. •miR-196a inhibited NTN4 expression by binding 3?-UTR region of NTN4 mRNA. •NTN4 inversely correlated with miR-196a expression in cervical tissue and cell line. •NTN4 expression was low in cervical cancer tissue compared to normal tissue. -- Abstract: Recent research has uncovered tumor-suppressive and oncogenic potential of miR-196a in various tumors. However, the expression and mechanism of its function in cervical cancer remains unclear. In this study, we assess relative expression of miR-196a in cervical premalignant lesions, cervical cancer tissues, and four cancer cell lines using quantitative real-time PCR. CaSki and HeLa cells were treated with miR-196a inhibitors, mimics, or pCDNA/miR-196a to investigate the role of miR-196a in cancer cell proliferation and migration. We demonstrated that miR-196a was overexpressed in cervical intraepithelial neoplasia 2–3 and cervical cancer tissue. Moreover, its expression contributes to the proliferation and migration of cervical cancer cells, whereas inhibiting its expression led to a reduction in proliferation and migration. Five candidate targets of miR-196a chosen by computational prediction and Cervical Cancer Gene Database search were measured for their mRNA in both miR-196a-overexpressing and -depleted cancer cells. Only netrin 4 (NTN4) expression displayed an inverse association with miR-196a. Fluorescent reporter assays revealed that miR-196a inhibited NTN4 expression by targeting one binding site in the 3?-untranslated region (3?-UTR) of NTN4 mRNA. Furthermore, qPCR and Western blot assays verified NTN4 expression was downregulated in cervical cancer tissues compared to normal controls, and in vivo mRNA level of NTN4 inversely correlated with miR-196a expression. In summary, our findings provide new insights about the functional role of miR-196a in cervical carcinogenesis and suggested a potential use of miR-196a for clinical diagnosis and as a therapeutic target.

  5. Towards accurate kinetic modeling of prompt NO formation in hydrocarbon flames via the NCN pathway

    SciTech Connect (OSTI)

    Sutton, Jeffrey A. [Department of Mechanical Engineering, The Ohio State University, Columbus, OH 43210 (United States); Fleming, James W. [Navy Technology Center for Safety and Survivability, Chemistry Division, Code 6185, Naval Research Laboratory, Washington, DC 20375-5342 (United States)

    2008-08-15T23:59:59.000Z

    A basic kinetic mechanism that can predict the appropriate prompt-NO precursor NCN, as shown by experiment, with relative accuracy while still producing postflame NO results that can be calculated as accurately as or more accurately than through the former HCN pathway is presented for the first time. The basic NCN submechanism should be a starting point for future NCN kinetic and prompt NO formation refinement.

  6. Radionuclide Migration through Sediment and Concrete: 16 Years of Investigations

    SciTech Connect (OSTI)

    Golovich, Elizabeth C.; Mattigod, Shas V.; Snyder, Michelle MV; Powers, Laura; Whyatt, Greg A.; Wellman, Dawn M.

    2014-11-06T23:59:59.000Z

    The Waste Management Project provides safe, compliant, and cost-effective waste management services for the Hanford Site and the U.S. Department of Energy (DOE) complex. Part of these services includes safe disposal of low-level waste and mixed low-level waste at the Hanford Low-Level Waste Burial Grounds in accordance with the requirements of DOE Order 435.1, Radioactive Waste Management. To partially satisfy these requirements, performance assessment analyses were completed and approved. DOE Order 435.1 also requires continuing data collection to increase confidence in the critical assumptions used in these analyses to characterize the operational features of the disposal facility that are relied on to satisfy the performance objectives identified in the order. Cement-based solidification and stabilization is considered for hazardous waste disposal because it is easily done and cost-efficient. One critical assumption is that concrete will be used as a waste form or container material at the Hanford Site to control and minimize the release of radionuclide constituents in waste into the surrounding environment. Concrete encasement would contain and isolate the waste packages from the hydrologic environment and act as an intrusion barrier. Any failure of concrete encasement may result in water intrusion and consequent mobilization of radionuclides from the waste packages. The radionuclides iodine-129, selenium-75, technetium-99, and uranium-238 have been identified as long-term dose contributors (Mann et al. 2001; Wood et al. 1995). Because of their anionic nature in aqueous solutions, these constituents of potential concern may be released from the encased concrete by mass flow and/or diffusion and migrate into the surrounding subsurface environment (Serne et al. 1989; 1992; 1993a, b; 1995). Therefore, it is necessary to assess the performance of the concrete encasement structure and the ability of the surrounding soil to retard radionuclide migration. Each of the test methods performed throughout the lifetime of the project has focused on different aspects of the concrete waste form weathering process. Diffusion of different analytes [technetium-99 (Tc-99), iodine-125 (I-125), stable iodine (I), uranium (U), and rhenium (Re)] has been quantified from experiments under both saturated and unsaturated conditions. The water-saturated conditions provide a conservative estimate of the concrete’s performance in situ, and the unsaturated conditions provide a more accurate estimate of the diffusion of contaminants from the concrete.

  7. Right Ventricular Migration of a Recovery IVC Filter's Fractured Wire with Subsequent Pericardial Tamponade

    SciTech Connect (OSTI)

    Saeed, Imran [Christiana Hospital, MAP 2, Suite 2121 (United States)], E-mail: isaeed@christianacare.org; Garcia, Mark [Christiana Hospital, Department of Radiology (United States); McNicholas, Kathleen [Christiana Hospital, MAP 1, Suite 205 (United States)

    2006-08-15T23:59:59.000Z

    A Recovery filter (C.R. Bard, Tempe, AZ, USA) is a device for pulmonary embolism prophylaxis. There have been few case reports involving the migration of this particular filter or of a broken wire migrating to the heart. We report a case of right ventricular migration of a fractured wire from this filter in a patient who subsequently developed pericardial tamponade and required open heart surgery to extract the fractured wire. We discuss the current US Food and Drug Administration (FDA)-approved nonpermanent inferior vena cava filters and their reported complications. These complications can be life-threatening and may require immediate surgical intervention.

  8. Systems biology of endothelial mechano-activated pathways

    E-Print Network [OSTI]

    Koo, Andrew Jia-An

    2013-01-01T23:59:59.000Z

    Multiple signaling pathways are employed by endothelial cells to differentially respond to distinct hemodynamic environments and acquire functional phenotypes, including regulation of inflammation, angiogenesis, blood ...

  9. Coregulation of terpenoid pathway genes and prediction of isoprene...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    described, there is a paucity of information regarding the system level regulation and control of the pathway. To address this limitation, we examined Bacillus subtilis grown...

  10. alternative pathway turnover: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    23 24 25 Next Page Last Page Topic Index 1 Questioning Inevitability of Energy Pathways: Alternative Energy Scenarios for California Renewable Energy Websites Summary: Questioning...

  11. alternative pathway responsible: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    23 24 25 Next Page Last Page Topic Index 1 Questioning Inevitability of Energy Pathways: Alternative Energy Scenarios for California Renewable Energy Websites Summary: Questioning...

  12. alternative pathway mediates: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    23 24 25 Next Page Last Page Topic Index 1 Questioning Inevitability of Energy Pathways: Alternative Energy Scenarios for California Renewable Energy Websites Summary: Questioning...

  13. Biological Conversion of Sugars to Hydrocarbons Technology Pathway...

    Broader source: Energy.gov (indexed) [DOE]

    for the pathway to become competitive with petroleum-derived gasoline-, diesel-, and jet-range hydrocarbon blendstocks. Biological Conversion of Sugars to Hydrocarbons...

  14. Bioenergy Technologies Office Conversion R&D Pathway: Whole Algae...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Whole Algae Hydrothermal Liquefaction Bioenergy Technologies Office Conversion R&D Pathway: Whole Algae Hydrothermal Liquefaction Whole algae hydrothermal liquefaction is one of...

  15. Bioenergy Technologies Office Conversion R&D Pathway: Syngas...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Syngas Upgrading to Hydrocarbon Fuels Bioenergy Technologies Office Conversion R&D Pathway: Syngas Upgrading to Hydrocarbon Fuels Syngas upgrading to hydrocarbon fuels is one of...

  16. A groundwater flow and transport model of long-term radionuclide migration in central Frenchman flat, Nevada test site

    SciTech Connect (OSTI)

    Kwicklis, Edward Michael [Los Alamos National Laboratory; Becker, Naomi M [Los Alamos National Laboratory; Ruskauff, Gregory [NAVARRO-INTERA, LLC.; De Novio, Nicole [GOLDER AND ASSOC.; Wilborn, Bill [US DOE NNSA NSO

    2010-11-10T23:59:59.000Z

    A set of groundwater flow and transport models were created for the Central Testing Area of Frenchman Flat at the former Nevada Test Site to investigate the long-term consequences of a radionuclide migration experiment that was done between 1975 and 1990. In this experiment, radionuclide migration was induced from a small nuclear test conducted below the water table by pumping a well 91 m away. After radionuclides arrived at the pumping well, the contaminated effluent was discharged to an unlined ditch leading to a playa where it was expected to evaporate. However, recent data from a well near the ditch and results from detailed models of the experiment by LLNL personnel have convincingly demonstrated that radionuclides from the ditch eventually reached the water table some 220 m below land surface. The models presented in this paper combine aspects of these detailed models with concepts of basin-scale flow to estimate the likely extent of contamination resulting from this experiment over the next 1,000 years. The models demonstrate that because regulatory limits for radionuclide concentrations are exceeded only by tritium and the half-life of tritium is relatively short (12.3 years), the maximum extent of contaminated groundwater has or will soon be reached, after which time the contaminated plume will begin to shrink because of radioactive decay. The models also show that past and future groundwater pumping from water supply wells within Frenchman Flat basin will have negligible effects on the extent of the plume.

  17. Cell migration or cytokinesis and proliferation? – Revisiting the “go or grow” hypothesis in cancer cells in vitro

    SciTech Connect (OSTI)

    Garay, Tamás; Juhász, Éva; Molnár, Eszter [2nd Department of Pathology, Semmelweis University, Budapest (Hungary); Eisenbauer, Maria [Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Vienna (Austria); Czirók, András [Department of Biological Physics, Eötvös University, Budapest (Hungary); Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS (United States); Dekan, Barbara; László, Viktória; Hoda, Mir Alireza [Department of Thoracic Surgery, Medical University of Vienna, Vienna (Austria); Döme, Balázs [Department of Thoracic Surgery, Medical University of Vienna, Vienna (Austria); National Korányi Institute of TB and Pulmonology, Budapest (Hungary); Tímár, József [2nd Department of Pathology, Semmelweis University, Budapest (Hungary); MTA-SE Tumor Progression Research Group, Hungarian Academy of Sciences, Budapest (Hungary); Klepetko, Walter [Department of Thoracic Surgery, Medical University of Vienna, Vienna (Austria); Berger, Walter [Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Vienna (Austria); Heged?s, Balázs, E-mail: balazs.hegedus@meduniwien.ac.at [Department of Thoracic Surgery, Medical University of Vienna, Vienna (Austria); MTA-SE Tumor Progression Research Group, Hungarian Academy of Sciences, Budapest (Hungary)

    2013-12-10T23:59:59.000Z

    The mortality of patients with solid tumors is mostly due to metastasis that relies on the interplay between migration and proliferation. The “go or grow” hypothesis postulates that migration and proliferation spatiotemporally excludes each other. We evaluated this hypothesis on 35 cell lines (12 mesothelioma, 13 melanoma and 10 lung cancer) on both the individual cell and population levels. Following three-day-long videomicroscopy, migration, proliferation and cytokinesis-length were quantified. We found a significantly higher migration in mesothelioma cells compared to melanoma and lung cancer while tumor types did not differ in mean proliferation or duration of cytokinesis. Strikingly, we found in melanoma and lung cancer a significant positive correlation between mean proliferation and migration. Furthermore, non-dividing melanoma and lung cancer cells displayed slower migration. In contrast, in mesothelioma there were no such correlations. Interestingly, negative correlation was found between cytokinesis-length and migration in melanoma. FAK activation was higher in melanoma cells with high motility. We demonstrate that the cancer cells studied do not defer proliferation for migration. Of note, tumor cells from various organ systems may differently regulate migration and proliferation. Furthermore, our data is in line with the observation of pathologists that highly proliferative tumors are often highly invasive. - Highlights: • We investigated the “go or grow” hypothesis in human cancer cells in vitro. • Proliferation and migration positively correlate in melanoma and lung cancer cells. • Duration of cytokinesis and migration shows inverse correlation. • Increased FAK activation is present in highly motile melanoma cells.

  18. SU-E-J-115: Using Markov Chain Modeling to Elucidate Patterns in Breast Cancer Metastasis Over Time and Space

    SciTech Connect (OSTI)

    Comen, E; Mason, J; Kuhn, P [The Scripps Research Institute, La Jolla, CA (United States); Nieva, J [Billings Clinic, Billings, Montana (United States); Newton, P [University of Southern California, Los Angeles, CA (United States); Norton, L; Venkatappa, N; Jochelson, M [Memorial Sloan-Kettering Cancer Center, NY, NY (United States)

    2014-06-01T23:59:59.000Z

    Purpose: Traditionally, breast cancer metastasis is described as a process wherein cancer cells spread from the breast to multiple organ systems via hematogenous and lymphatic routes. Mapping organ specific patterns of cancer spread over time is essential to understanding metastatic progression. In order to better predict sites of metastases, here we demonstrate modeling of the patterned migration of metastasis. Methods: We reviewed the clinical history of 453 breast cancer patients from Memorial Sloan Kettering Cancer Center who were non-metastatic at diagnosis but developed metastasis over time. We used the variables of organ site of metastases as well as time to create a Markov chain model of metastasis. We illustrate the probabilities of metastasis occurring at a given anatomic site together with the probability of spread to additional sites. Results: Based on the clinical histories of 453 breast cancer patients who developed metastasis, we have learned (i) how to create the Markov transition matrix governing the probabilities of cancer progression from site to site; (ii) how to create a systemic network diagram governing disease progression modeled as a random walk on a directed graph; (iii) how to classify metastatic sites as ‘sponges’ that tend to only receive cancer cells or ‘spreaders’ that receive and release them; (iv) how to model the time-scales of disease progression as a Weibull probability distribution function; (v) how to perform Monte Carlo simulations of disease progression; and (vi) how to interpret disease progression as an entropy-increasing stochastic process. Conclusion: Based on our modeling, metastatic spread may follow predictable pathways. Mapping metastasis not simply by organ site, but by function as either a ‘spreader’ or ‘sponge’ fundamentally reframes our understanding of metastatic processes. This model serves as a novel platform from which we may integrate the evolving genomic landscape that drives cancer metastasis. PS-OC Trans-Network Project Grant Award for “Data Assimilation and ensemble statistical forecasting methods applied to the MSKCC longitudinal metastatic breast cancer cohort.”.

  19. Survival Estimates for the Passage of Spring-Migrating Juvenile Salmonids through Snake and Columbia River Dams and Reservoirs, 2008.

    SciTech Connect (OSTI)

    Faulkner, James R.; Smith, Steven G.; Muir, William D. [Northwest Fisheries Science Center

    2009-06-23T23:59:59.000Z

    In 2008, the National Marine Fisheries Service completed the sixteenth year of a study to estimate survival and travel time of juvenile salmonids Oncorhynchus spp. passing through dams and reservoirs on the Snake and Columbia Rivers. All estimates were derived from detections of fish tagged with passive integrated transponder (PIT) tags. We PIT tagged and released a total of 18,565 hatchery steelhead O. mykiss, 15,991 wild steelhead, and 9,714 wild yearling Chinook salmon O. tshawytscha at Lower Granite Dam in the Snake River. In addition, we utilized fish PIT tagged by other agencies at traps and hatcheries upstream from the hydropower system and at sites within the hydropower system in both the Snake and Columbia Rivers. These included 122,061 yearling Chinook salmon tagged at Lower Granite Dam for evaluation of latent mortality related to passage through Snake River dams. PIT-tagged smolts were detected at interrogation facilities at Lower Granite, Little Goose, Lower Monumental, Ice Harbor, McNary, John Day, and Bonneville Dams and in the PIT-tag detector trawl operated in the Columbia River estuary. Survival estimates were calculated using a statistical model for tag-recapture data from single release groups (the single-release model). Primary research objectives in 2008 were to: (1) estimate reach survival and travel time in the Snake and Columbia Rivers throughout the migration period of yearling Chinook salmon and steelhead, (2) evaluate relationships between survival estimates and migration conditions, and (3) evaluate the survival estimation models under prevailing conditions. This report provides reach survival and travel time estimates for 2008 for PIT-tagged yearling Chinook salmon (hatchery and wild), hatchery sockeye salmon O. nerka, hatchery coho salmon O. kisutch, and steelhead (hatchery and wild) in the Snake and Columbia Rivers. Additional details on the methodology and statistical models used are provided in previous reports cited here. Survival and detection probabilities were estimated precisely for most of the 2008 yearling Chinook salmon and steelhead migrations. Hatchery and wild fish were combined in some of the analyses. For yearling Chinook salmon, overall percentages for combined release groups used in survival analyses in the Snake River were 80% hatchery-reared and 20% wild. For steelhead, the overall percentages were 65% hatchery-reared and 35% wild. Estimated survival from the tailrace of Lower Granite Dam to the tailrace of Little Goose Dam averaged 0.939 for yearling Chinook salmon and 0.935 for steelhead.

  20. The role of macrophage chemoattractant signaling in cancer cell migration, metastasis and neovascularization

    E-Print Network [OSTI]

    Liu, Tiffany

    2010-01-01T23:59:59.000Z

    2007) Stroma-derived factor (SDF-1/ CXCL12) and human tumorCells..15 3.4 SDF-1?, VEGF andMAB Migration Adhesion Buffer SDF-1? Stromal Derived Factor-

  1. Evolutionary History of Helicobacter pylori Sequences Reflect Past Human Migrations in Southeast Asia

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Evolutionary History of Helicobacter pylori Sequences Reflect Past Human Migrations in Southeast analyse housekeeping gene sequences of the human stomach bacterium Helicobacter pylori from various, Dieye FB, et al. (2011) Evolutionary History of Helicobacter pylori Sequences Reflect Past Human

  2. Survival of Terrestrial Planets in the Presence of Giant Planet Migration

    E-Print Network [OSTI]

    Avi M. Mandell; Steinn Sigurdsson

    2003-11-10T23:59:59.000Z

    The presence of ``Hot Jupiters'', Jovian mass planets with very short orbital periods orbiting nearby main sequence stars, has been proposed to be primarily due to the orbital migration of planets formed in orbits initially much further from the parent star. The migration of giant planets would have profound effects on the evolution of inner terrestrial planets in these systems, and previous analyses have assumed that no terrestrial planets survive after migration has occurred. We present numerical simulations showing that a significant fraction of terrestrial planets could survive the migration process, eventually returning to circular orbits relatively close to their original positions. A fraction of the final orbits are in the Habitable Zone, suggesting that planetary systems with close-in giant planets are viable targets for searches for Earth-like habitable planets around other stars.

  3. Quantitative approaches to understanding signaling regulation of 3D cell migration

    E-Print Network [OSTI]

    Meyer, Aaron Samuel

    2014-01-01T23:59:59.000Z

    For many cancers, dissemination of tumor cells to form metastases is not only a hallmark of the disease but an essential step to mortality. Migration and dissemination are complex, multistep processes, and study of their ...

  4. Oxygen Vacancy Formation and Migration in CexTh_xO Solid Solution...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of magnetic properties by varying the CeO&8322; content. Citation: Xiao HY, and WJ Weber.2011."Oxygen Vacancy Formation and Migration in CexTh?xO? Solid Solution."Journal of...

  5. Migration of the European sea bass Cefas have been collaborating with IFREMER scientists and the Breton

    E-Print Network [OSTI]

    Migration of the European sea bass Cefas have been collaborating with IFREMER scientists bass, Dicentrarchus labrax. Although a popular and important catch for both commercial and recreational fishermen, relatively little is known about the behaviour of this highly migratory fish

  6. A Foraging Cost of Migration for a Partially Migratory Cyprinid Fish

    E-Print Network [OSTI]

    ­70% of their energy reserves during their spawning migration [12], and both sustained flight and also stop, Lund University, Lund, Sweden, 2 National Institute of Aquatic Resources, Technical University

  7. Implementing Incremental Code Migration with XML Wolfgang Emmerich, Cecilia Mascolo \\Lambda and Anthony Finkelstein

    E-Print Network [OSTI]

    Mascolo, Cecilia

    Implementing Incremental Code Migration with XML Wolfgang Emmerich, Cecilia Mascolo \\Lambda fW.Emmerich|C.Mascolo|A.Finkelsteing@cs.ucl.ac.uk ABSTRACT We demonstrate how XML and related

  8. Biased migration of confined neutrophil-like cells in asymmetric hydraulic environments

    E-Print Network [OSTI]

    Mahadevan, L.

    Cells integrate multiple measurement modalities to navigate their environment. Soluble and substrate-bound chemical gradients and physical cues have all been shown to influence cell orientation and migration. Here we ...

  9. Pressure solution and microfracturing in primary oil migration, upper cretaceous Austin Chalk, Texas Gulf Coast 

    E-Print Network [OSTI]

    Chanchani, Jitesh

    1994-01-01T23:59:59.000Z

    The Upper Cretaceous Austin Chalk is a well known source rock and fractured reservoir. Production is mainly from fractures, and the mechanism by which oil migrates from the matrix into the fractures is not well understood. Microfracturing due...

  10. Area 2: Inexpensive Monitoring and Uncertainty Assessment of CO2 Plume Migration using Injection Data

    SciTech Connect (OSTI)

    Srinivasan, Sanjay

    2014-09-30T23:59:59.000Z

    In-depth understanding of the long-term fate of CO2 in the subsurface requires study and analysis of the reservoir formation, the overlaying caprock formation, and adjacent faults. Because there is significant uncertainty in predicting the location and extent of geologic heterogeneity that can impact the future migration of CO2 in the subsurface, there is a need to develop algorithms that can reliably quantify this uncertainty in plume migration. This project is focused on the development of a model selection algorithm that refines an initial suite of subsurface models representing the prior uncertainty to create a posterior set of subsurface models that reflect injection performance consistent with that observed. Such posterior models can be used to represent uncertainty in the future migration of the CO2 plume. Because only injection data is required, the method provides a very inexpensive method to map the migration of the plume and the associated uncertainty in migration paths. The model selection method developed as part of this project mainly consists of assessing the connectivity/dynamic characteristics of a large prior ensemble of models, grouping the models on the basis of their expected dynamic response, selecting the subgroup of models that most closely yield dynamic response closest to the observed dynamic data, and finally quantifying the uncertainty in plume migration using the selected subset of models. The main accomplishment of the project is the development of a software module within the SGEMS earth modeling software package that implements the model selection methodology. This software module was subsequently applied to analyze CO2 plume migration in two field projects – the In Salah CO2 Injection project in Algeria and CO2 injection into the Utsira formation in Norway. These applications of the software revealed that the proxies developed in this project for quickly assessing the dynamic characteristics of the reservoir were highly efficient and yielded accurate grouping of reservoir models. The plume migration paths probabilistically assessed by the method were confirmed by field observations and auxiliary data. The report also documents the application of the software to answer practical questions such as the optimum location of monitoring wells to reliably assess the migration of CO2 plume, the effect of CO2-rock interactions on plume migration and the ability to detect the plume under those conditions and the effect of a slow, unresolved leak on the predictions of plume migration.

  11. Global Migration in Transition: The Americas, Europe, and Italian Diaspora (1946-1960)

    E-Print Network [OSTI]

    Maccari-Clayton, Marina

    2010-12-31T23:59:59.000Z

    of Italian emigration, see Federica Bertagna and Marina Maccari, “Italy,” in The Encyclopedia of European Migrations and Minorities, eds. Klaus Bade, Piter Emmer, Leo Lucassen, and Jochen Oltmer (Cambridge University Press, forthcoming in 2011) 3 For data... and Reappraisal,” Population and Development Review, 19, 3 (1993): 431-466; C. Stahl, “Explaining international migration,” in Global Population Movements and their Implications for Australia, eds. C. Sthal, R. Ball, C, Inglis, and P. Gutman (Canberra...

  12. Migration of the ATLAS Metadata Interface (AMI) to Web 2.0 and cloud

    E-Print Network [OSTI]

    Odier, Jerome; The ATLAS collaboration; Fulachier, Jerome; Lambert, Fabian

    2015-01-01T23:59:59.000Z

    The ATLAS Metadata Interface (AMI), a mature application of more than 10 years of existence, is currently under adaptation to some recently available technologies. The web interfaces, which previously manipulated XML documents using XSL transformations, are being migrated to Asynchronous JavaScript (AJAX). Web development is considerably simplified by the introduction of a framework based on JQuery and Twitter Bootstrap. Finally, the AMI services are being migrated to an OpenStack cloud infrastructure.

  13. An investigation of pneumatic control on immiscible contaminant migration in confined aquifers 

    E-Print Network [OSTI]

    Watts, John David

    1991-01-01T23:59:59.000Z

    AN INVESTIGATION OF PNEUMATIC CONTROL ON IMMISCIBLE CONTAMINANT MIGRATION IN CONFINED AQUIFERS A Thesis by JOHN DAVID WATTS Submitted to the Office of Graduate Studies of Texas AkM University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE May 1991 Major Subject: Civil Engineering AN INVESTIGATION OF PNEUMATIC CONTROL ON IMMISCIBLE CONTAMINANT MIGRATION IN CONFINED AQUIFERS A Thesis by JOHN DAVID %VATTS Approved as to style and content by: W e . mes...

  14. Physics Pathway: A Digital Library Filled with Synthetic Interviews*

    E-Print Network [OSTI]

    Christel, Mike

    Physics Pathway: A Digital Library Filled with Synthetic Interviews* Michael G. Christel-412-268-7796 sms@cs.cmu.edu Dean Zollman Department of Physics Kansas State University Manhattan, KS 66506 1-785-532-1619 dzollman@phys.ksu.edu ABSTRACT Physics Pathway is a digital library available through an Adobe Flash portal

  15. Bioenergy Production Pathways and Value-Chain Components

    E-Print Network [OSTI]

    Bioenergy Production Pathways and Value-Chain Components Prepared for the U.S. Department of Energy on Life Cycle Analyses of Bioenergy Systems Prepared by Hawai`i Natural Energy Institute School of Ocean or reflect those of the United States Government or any agency thereof. #12;Bioenergy Production Pathways

  16. In-Situ Catalytic Fast Pyrolysis Technology Pathway

    SciTech Connect (OSTI)

    Biddy, M.; Dutta, A.; Jones, S.; Meyer, A.

    2013-03-01T23:59:59.000Z

    This technology pathway case investigates converting woody biomass using in-situ catalytic fast pyrolysis followed by upgrading to gasoline-, diesel-, and jet-range hydrocarbon blendstocks. Technical barriers and key research needs that should be pursued for this pathway to be competitive with petroleum-derived blendstocks have been identified.

  17. Ex-Situ Catalytic Fast Pyrolysis Technology Pathway

    SciTech Connect (OSTI)

    Biddy, M.; Dutta, A.; Jones, S.; Meyer, A.

    2013-03-01T23:59:59.000Z

    This technology pathway case investigates converting woody biomass using ex-situ catalytic fast pyrolysis followed by upgrading to gasoline-, diesel-, and jet-range hydrocarbon blendstocks. Technical barriers and key research needs that should be pursued for this pathway to be competitive with petroleum-derived blendstocks have been identified.

  18. Modelling Inhibition in Metabolic Pathways Through Abduction and Induction

    E-Print Network [OSTI]

    Pazos, Florencio

    Modelling Inhibition in Metabolic Pathways Through Abduction and Induction Alireza Tamaddoni abduction and induction can be used to understand the functional class of unknown enzymes or inhibitors. We show how we can model, within Abductive Logic Programming (ALP), inhibition in metabolic pathways

  19. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan, batteries, and ultracapacitors. Andrew #12;316 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS AUTHORS://creativecommons.org/licenses/by-nc-nd/3.0/>. For information on commercial licensing, contact copyright@ucdavis.edu. #12;315 SUSTAINABLE

  20. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan Ogden and Lorraine Anderson #12;Institute of Transportation Studies University of California, Davis One TRANSPORTATION ENERGY PATHWAYS PART 3: SCENARIOS FOR A LOW-CARBON TRANSPORTATION FUTURE PART 3 Part 3: Scenarios

  1. Biological Conversion of Sugars to Hydrocarbons Technology Pathway

    SciTech Connect (OSTI)

    Davis, R.; Biddy, M.; Tan, E.; Tao, L.; Jones, S.

    2013-03-01T23:59:59.000Z

    This technology pathway case investigates the biological conversion of biomass-derived sugars to hydrocarbon biofuels, utilizing data from recent literature references and information consistent with recent pilot-scale demonstrations at NREL. Technical barriers and key research needs have been identified that should be pursued for the pathway to become competitive with petroleum-derived gasoline-, diesel-, and jet-range hydrocarbon blendstocks.

  2. SPIKE: a database of highly curated human signaling pathways

    E-Print Network [OSTI]

    Avraham, Karen

    SPIKE: a database of highly curated human signaling pathways Arnon Paz1 , Zippora Brownstein1 Knowledge Engine; http:// www.cs.tau.ac.il/spike/) is a database for achieving this goal, containing highly on the nature of each interaction. To make database population and pathway comprehension straightforward

  3. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    -duty markets for advanced electric-drive technologies such as plug-in hybrids and hydrogen fuel cell vehicles electric vehicles (PHEVs) play a major role beyond 2025. · FCV success--Hydrogen fuel cell vehicles (FCVs TRANSPORTATION ENERGY PATHWAYS PART 1: INDIVIDUAL FUEL/VEHICLE PATHWAYS PART 3 Chapter 9: Transition Scenarios

  4. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    , analysts, policy makers, and the public began to worry that burning coal, oil, and gas would affectSUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan TRANSPORTATION ENERGY PATHWAYS PART 4 CHAPTER 13: BEYOND LIFE-CYCLE ANALYSIS Chapter 13: Beyond Life

  5. Haloarchaeal Protein Translocation via the Twin Arginine Translocation Pathway

    SciTech Connect (OSTI)

    Pohlschroder Mechthild

    2009-02-03T23:59:59.000Z

    Protein transport across hydrophobic membranes that partition cellular compartments is essential in all cells. The twin arginine translocation (Tat) pathway transports proteins across the prokaryotic cytoplasmic membranes. Distinct from the universally conserved Sec pathway, which secretes unfolded proteins, the Tat machinery is unique in that it secretes proteins in a folded conformation, making it an attractive pathway for the transport and secretion of heterologously expressed proteins that are Sec-incompatible. During the past 7 years, the DOE-supported project has focused on the characterization of the diversity of bacterial and archaeal Tat substrates as well as on the characterization of the Tat pathway of a model archaeon, Haloferax volcanii, a member of the haloarchaea. We have demonstrated that H. volcanii uses this pathway to transport most of its secretome.

  6. Entropic Time

    SciTech Connect (OSTI)

    Caticha, Ariel [Department of Physics, University at Albany-SUNY, Albany, NY 12222 (United States)

    2011-03-14T23:59:59.000Z

    The formulation of quantum mechanics within the framework of entropic dynamics includes several new elements. In this paper we concentrate on one of them: the implications for the theory of time. Entropic time is introduced as a book-keeping device to keep track of the accumulation of changes. One new feature is that, unlike other concepts of time appearing in the so-called fundamental laws of physics, entropic time incorporates a natural distinction between past and future.

  7. Gas pile-up, gap overflow, and Type 1.5 migration in circumbinary disks: application to supermassive black hole binaries

    E-Print Network [OSTI]

    Bence Kocsis; Zoltan Haiman; Abraham Loeb

    2012-09-13T23:59:59.000Z

    We study the interaction of a supermassive black hole (SMBH) binary and a standard radiatively efficient thin accretion disk. We examine steady-state configurations of the disk and migrating SMBH system, self-consistently accounting for tidal and viscous torques and heating, radiative diffusion limited cooling, gas and radiation pressure, and the decay of the binary's orbit. We obtain a "phase diagram" of the system as a function of binary parameters, showing regimes in which both the disk structure and migration have a different character. Although massive binaries can create a central gap in the disk at large radii, the tidal barrier of the secondary causes a significant pile-up of gas outside of its orbit, which can lead to the closing of the gap. We find that this spillover occurs at an orbital separation as large as ~200 M_7^{-1/2} gravitational radii, where M = 10^7 M_7 Msun is the total binary mass. If the secondary is less massive than ~10^6 Msun, then the gap is closed before gravitational waves (GWs) start dominating the orbital decay. In this regime, the disk is still strongly perturbed, but the piled-up gas continuously overflows as in a porous dam, and crosses inside the secondary's orbit. The corresponding migration rate, which we label Type 1.5, is slower than the usual limiting cases known as Type I and II migration. Compared to an unperturbed disk, the steady-state disk in the overflowing regime is up to several hundred times brighter in the optical bands. Surveys such as PanSTARRS or LSST may discover the periodic variability of this population of binaries. Our results imply that the circumbinary disks around SMBHs can extend to small radii during the last stages of their merger, when they are detectable by LISA, and may produce coincident electromagnetic (EM) emission similar to active galactic nuclei (AGN).

  8. A Sea Floor Gravity Survey of the Sleipner Field to Monitor CO2 Migration

    SciTech Connect (OSTI)

    Mark Zumberge

    2011-09-30T23:59:59.000Z

    Carbon dioxide gas (CO{sub 2}) is a byproduct of many wells that produce natural gas. Frequently the CO{sub 2} separated from the valuable fossil fuel gas is released into the atmosphere. This adds to the growing problem of the climatic consequences of greenhouse gas contamination. In the Sleipner North Sea natural gas production facility, the separated CO{sub 2} is injected into an underground saline aquifer to be forever sequestered. Monitoring the fate of such sequestered material is important - and difficult. Local change in Earth's gravity field over the injected gas is one way to detect the CO{sub 2} and track its migration within the reservoir over time. The density of the injected gas is less than that of the brine that becomes displaced from the pore space of the formation, leading to slight but detectable decrease in gravity observed on the seafloor above the reservoir. Using equipment developed at Scripps Institution of Oceanography, we have been monitoring gravity over the Sleipner CO{sub 2} sequestration reservoir since 2002. We surveyed the field in 2009 in a project jointly funded by a consortium of European oil and gas companies and the US Department of Energy. The value of gravity at some 30 benchmarks on the seafloor, emplaced at the beginning of the monitoring project, was observed in a week-long survey with a remotely operated vehicle. Three gravity meters were deployed on the benchmarks multiple times in a campaign-style survey, and the measured gravity values compared to those collected in earlier surveys. A clear signature in the map of gravity differences is well correlated with repeated seismic surveys.

  9. Cloud Migration: A Case Study of Migrating an Enterprise IT System to IaaS Ali Khajeh-Hosseini David Greenwood Ian Sommerville

    E-Print Network [OSTI]

    Sommerville, Ian

    the potential benefits and risks associated with the migration of an IT system in the oil & gas industry from the enterprise, thus transcending the typical, yet narrow, financial and technical analysis offered by providers stakeholder impact analysis revealed that there are significant risks associated with this. Whilst

  10. Cyclone-cyclone Interactions through the Ocean Pathway

    SciTech Connect (OSTI)

    Balaguru, Karthik; Taraphdar, Sourav; Leung, Lai-Yung R.; Foltz, Gregory R.; Knaff, John A.

    2014-10-16T23:59:59.000Z

    The intense SST (Sea Surface Temperature) cooling caused by hurricane-induced mixing is restored at timescales on the order of weeks(1) and thus may persist long enough to influence a later hurricane passing over it. Though many studies have evaluated the effects of SST cool-ing induced by a hurricane on its own intensification(2, 3), none has looked at its effect on later storms. Using an analysis of observations and numerical model simulations, we demonstrate that hurricanes may influence the intensity of later hurricanes that pass over their linger-ing wakes. On average, when hurricanes encounter cold wakes, they experience SSTs that are ~0.4oC lower than when they do not encounter wakes and consequently decay(intensify) at a rate that is nearly three times faster(slower). In the region of warm SSTs (* 26.5oC) where the most intense and damaging hurricanes tend to occur, the percentage of hurricanes that encounter lingering cold wakes increases with hurricane frequency and was found to be as high as 40%. Furthermore, we estimate that the cumulative power dissipated(4) by the most energetic hurricanes has been reduced by as much as ~7% in a season through this effect. As the debate on changes in Atlantic hurricane activity associated with global warming(5) continues, the negative feedback between hurricane frequency and intensity resulting from hurricane-hurricane interactions through the ocean pathway deserves attention.

  11. A 4D synchrotron X-ray tomography study of the formation of hydrocarbon migration pathways in heated organic-rich shale

    E-Print Network [OSTI]

    Boyer, Edmond

    . Institute for Energy Technology, Kjeller, Norway Abstract Recovery of oil from oil shales and the natural

  12. Survival Estimates for the Passage of Spring-Migrating Juvenile Salmonids through Snake and Columbia River Dams and Reservoirs, 2001-2002 Annual Report.

    SciTech Connect (OSTI)

    Zabel, Richard; Williams, John G.; Smith, Steven G. (Northwest and Alaska Fisheries Science Center, Fish Ecology Division, Seattle, WA)

    2002-06-01T23:59:59.000Z

    In 2001, the National Marine Fisheries Service and the University of Washington completed the ninth year of a study to estimate survival and travel time of juvenile salmonids (Oncorhynchus spp.) passing through dams and reservoirs on the Snake and Columbia Rivers. All estimates were derived from passive integrated transponder (PIT)-tagged fish. We PIT tagged and released at Lower Granite Dam a total of 17,028 hatchery and 3,550 wild steelhead. In addition, we utilized fish PIT tagged by other agencies at traps and hatcheries upstream of the hydropower system and sites within the hydropower system. PIT-tagged smolts were detected at interrogation facilities at Lower Granite, Little Goose, Lower Monumental, McNary, John Day, and Bonneville Dams and in the PIT-tag detector trawl operated in the Columbia River estuary. Survival estimates were calculated using the Single-Release Model. Primary research objectives in 2001 were to: (1) estimate reach and project survival and travel time in the Snake and Columbia Rivers throughout the yearling chinook salmon and steelhead migrations; (2) evaluate relationships between survival estimates and migration conditions; and (3) evaluate the survival-estimation models under prevailing conditions. This report provides reach survival and travel time estimates for 2001 for PIT-tagged yearling chinook salmon and steelhead (hatchery and wild) in the Snake and Columbia Rivers. Results are reported primarily in the form of tables and figures with a minimum of text. More details on methodology and statistical models used are provided in previous reports cited in the text. Results for summer-migrating chinook salmon will be reported separately.

  13. E-Print Network 3.0 - accelerating ultimate pathways Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Computer Technologies and Information Sciences 17 A unified mechanism for protein folding: Predetermined pathways with optional errors Summary: ; therefore the off-pathway...

  14. Lifecycle impacts of natural gas to hydrogen pathways on urban air quality

    E-Print Network [OSTI]

    Wang, Guihua; Ogden, Joan M; Nicholas, Michael A

    2007-01-01T23:59:59.000Z

    pathway are due to diesel truck emissions resulting from the20% scenario). For the truck pathway, emissions tend to bePipeline, Onsite, Truck, VOC emission source (%) Pipeline,

  15. Chromatin landscaping in algae reveals novel regulation pathway for biofuels production

    E-Print Network [OSTI]

    Ngan, Chew Yee

    2014-01-01T23:59:59.000Z

    regulation pathway for biofuels production Chew Yee Ngan ,regulation pathway for biofuels production Chew Yee Ngan,for the development of biofuels. Biofuels are produced from

  16. Novel Insights into the Downstream Pathways and Targets Controlled by Transcription Factors CREM in the Testis

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    proteins in spermatids: Downstream targets and implicationsNovel Insights into the Downstream Pathways and TargetsNovel Insights into the Downstream Pathways and Targets

  17. atm-activated chk2-executed pathway: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    below CS111. Website: http:www.cs.bu.edu; Contact: Wayne Snyder, snyder Goldberg, Bennett 8 Biological Pathways A pathway to explore diseases mechanism Biology and Medicine...

  18. SNP-based pathway enrichment analysis for genome-wide association studies

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    SNP: applying gene set enrichment analysis to SNP data fromdetection of pathway enrichment in genome-wide associational. : SNP-based pathway enrichment analysis for genome-wide

  19. Pathway Controlled Penetration (PcP)

    SciTech Connect (OSTI)

    Knight, Earl E. [Los Alamos National Laboratory; Rougier, Esteban [Los Alamos National Laboratory; Zubelewicz, Aleksander [Los Alamos National Laboratory

    2012-08-29T23:59:59.000Z

    The technical approach employs advanced computational simulation tools to demonstrate how current assets can destroy RWK-RFI-12-0001's HDBT, a tunnel complex with two portals built into the base of a granite mountain. The granite over layer is assumed to be 60 meters thick over both portals and 80 meters over the facility's mission space. Key S&T is the completed development of a highly innovative viscoplastic fracture material model, 3D parallel gas-fracture capabilities into FDEM, and a stochastic handling of the material properties. Phase I - Develop and validate code simulation tools: (1) develop, incorporate and validate AZ-Frac material model for granite; and (2) Develop and incorporate gas-driven-fracture modeling into LANL's FDEM MUNROU code; (3) Develop and incorporate stochastic features into FDEM modeling. Phase II - Conduct PcP analysis on above HDBT: (1) Acquire HDBT design data, develop simulation model; and (2) Evaluate and select most promising defeat alternative. Phase III - Deliver code, train Service target analysts, and conduct simulations against real world HDBTs. PcP uses advanced computer simulations to enhance HDBT functional defeat efforts. Newly developed material models that account for fractural energy coupled with the finite discrete element methodology (FDEM) will provide targeting packages that will create penetration avenues for current or future lethality options. This novel computational approach requires full 3D geologic and structure characterization as well as significant high performance computing capabilities. The goal is to distinctively alter the targeting paradigm by leveraging critical DoD assets along with insitu geologic strata. In other words, assets will utilize underground rock structure to their benefit by creating rubbilization zones that will allow pathway controlled penetration.

  20. Monitoring the Migrations of Wild Snake River Spring/Summer Chinook Salmon Juveniles, 2007-2008 Report of Research.

    SciTech Connect (OSTI)

    Achord, Stephen; Sandford, Benjamin P.; Hockersmith, Eric E. [Northwest Fisheries Science Center

    2009-05-26T23:59:59.000Z

    This report provides results from an ongoing project to monitor the migration behavior and survival of wild juvenile spring/summer Chinook salmon in the Snake River Basin. Data reported is from detections of PIT tagged fish during late summer 2007 through mid-2008. Fish were tagged in summer 2007 by the National Marine Fisheries Service (NMFS) in Idaho and by the Oregon Department of Fish and Wildlife (ODFW) in Oregon. Our analyses include migration behavior and estimated survival of fish at instream PIT-tag monitors and arrival timing and estimated survival to Lower Granite Dam. Principal results from tagging and interrogation during 2007-2008 are listed below: (1) In July and August 2007, we PIT tagged and released 7,390 wild Chinook salmon parr in 12 Idaho streams or sample areas. (2) Overall observed mortality from collection, handling, tagging, and after a 24-hour holding period was 1.4%. (3) Of the 2,524 Chinook salmon parr PIT tagged and released in Valley Creek in summer 2007, 218 (8.6%) were detected at two instream PIT-tag monitoring systems in lower Valley Creek from late summer 2007 to the following spring 2008. Of these, 71.6% were detected in late summer/fall, 11.9% in winter, and 16.5% in spring. Estimated parr-to-smolt survival to Lower Granite Dam was 15.5% for the late summer/fall group, 48.0% for the winter group, and 58.5% for the spring group. Based on detections at downstream dams, the overall efficiency of VC1 (upper) or VC2 (lower) Valley Creek monitors for detecting these fish was 21.1%. Using this VC1 or VC2 efficiency, an estimated 40.8% of all summer-tagged parr survived to move out of Valley Creek, and their estimated survival from that point to Lower Granite Dam was 26.5%. Overall estimated parr-to-smolt survival for all summer-tagged parr from this stream at the dam was 12.1%. Development and improvement of instream PIT-tag monitoring systems continued throughout 2007 and 2008. (4) Testing of PIT-tag antennas in lower Big Creek during 2007-2008 showed these antennas (and anchoring method) are not adequate to withstand high spring flows in this drainage. Future plans involve removing these antennas before high spring flows. (5) At Little Goose Dam in 2008, length and/or weight were taken on 505 recaptured fish from 12 Idaho stream populations. Fish had grown an average of 40.1 mm in length and 10.6 g in weight over an average of 288 d. Their mean condition factor declined from 1.25 at release (parr) to 1.05 at recapture (smolt). (6) Mean release lengths for detected fish were significantly larger than for fish not detected the following spring and summer (P < 0.0001). (7) Fish that migrated through Lower Granite Dam in April and May were significantly larger at release than fish that migrated after May (P < 0.0001) (only 12 fish migrated after May). (8) In 2008, peak detections at Lower Granite Dam of parr tagged during summer 2007 (from the 12 stream populations in Idaho and 4 streams in Oregon) occurred during moderate flows of 87.5 kcfs on 7 May and high flows of 197.3 kcfs on 20 May. The 10th, 50th, and 90th percentile passage occurred on 30 April, 11 May, and 23 May, respectively. (9) In 2007-2008, estimated parr-to-smolt survival to Lower Granite Dam for Idaho and Oregon streams (combined) averaged 19.4% (range 6.2-38.4% depending on stream of origin). In Idaho streams the estimated parr-to-smolt survival averaged 21.0%. This survival was the second highest since 1993 for Idaho streams. Relative parr densities were lower in 2007 (2.4 parr/100 m{sup 2}) than in all previous years since 2000. In 2008, we observed low-to-moderate flows prior to mid-May and relatively cold weather conditions throughout the spring migration season. These conditions moved half of the fish through Lower Granite Dam prior to mid-May; then high flows moved 50 to 90% of the fish through the dam in only 12 days. Clearly, complex interrelationships of several factors drive the annual migrational timing of the stocks.

  1. Waltzing of a helium pair in tungsten: Migration barrier and trajectory revealed from first-principles

    SciTech Connect (OSTI)

    Niu, J. G. [School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083 (China); Department of Mechanical Engineering, Hebei University, Baoding 071000 (China); Zhan, Q., E-mail: qzhan@mater.ustb.edu.cn [School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083 (China); Geng, W. T., E-mail: geng@ustb.edu.cn [School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083 (China); Psi Quantum Materials LLC, Laiwu 271100 (China)

    2014-06-15T23:59:59.000Z

    Despite well documented first-principles theoretical determination of the low migration energy (0.06 eV) of a single He in tungsten, fully quantum mechanical calculations on the migration of a He pair still present a challenge due to the complexity of its trajectory. By identifying the six most stable configurations of the He pair in W and decomposing its motion into rotational, translational, and rotational-translational routines, we are able to determine its migration barrier and trajectory. Our density functional theory calculations demonstrate a He pair has three modes of motion: a close or open circular two-dimensional motion in (100) plane with an energy barrier of 0.30 eV, a snaking motion along [001] direction with a barrier of 0.30 eV, and a twisted-ladder motion along [010] direction with the two He swinging in the plane (100) and a barrier of 0.31 eV. The graceful associative movements of a He pair are related to the chemical-bonding-like He-He interaction being much stronger than its migration barrier in W. The excellent agreement with available experimental measurements (0.24–0.32 eV) on He migration makes our first-principles result a solid input to obtain accurate He-W interatomic potentials in molecular dynamics simulations.

  2. Investigation of Tc Migration Mechanism During Bulk Vitrification Process Using Re Surrogate

    SciTech Connect (OSTI)

    Kim, Dong-Sang; Bagaasen, Larry M.; Crum, Jarrod V.; Fluegel, Alex; Gallegos, Autumn B.; Martinez, Baudelio; Matyas, Josef; Meyer, Perry A.; Paulsen, Dan; Riley, Brian J.; Schweiger, Michael J.; Stewart, Charles W.; Swoboda, Robert G.; Yeager, John D.

    2006-12-04T23:59:59.000Z

    As a part of Bulk vitrification (BV) performance enhancement tasks, Laboratory scoping tests were performed in FY 2004-2005 to explore possible ways to reduce the amount of soluble Tc in the BV waste package. Theses scoping tests helped identify which mechanisms play an important role in the migration of Tc in the BV process (Hrma et al. 2005 and Kim et al. 2005). Based on the results from these scoping tests, additional tests were identified that will improve the understanding of Tc migration and to clearly identify the dominant mechanisms. The additional activities identified from previous studies were evaluated and prioritized for planning for Tasks 29 and 30 conducted in FY2006. Task 29 focused on the improved understanding of Tc migration mechanisms, and Task 30 focused on identifying the potential process changes that might reduce Tc/Re migration into the castable refractory block (CRB). This report summarizes the results from the laboratory- and crucible-scale tests in the lab for improved Tc migration mechanism understanding utilizing Re as a surrogate performed in Task 29.

  3. Photovoltaic Lifetime & Degradation Science Statistical Pathway Development: Acrylic Degradation

    E-Print Network [OSTI]

    Rollins, Andrew M.

    Photovoltaic Lifetime & Degradation Science Statistical Pathway Development: Acrylic Degradation, USA ABSTRACT In order to optimize and extend the life of photovoltaics (PV) modules, scientific photovoltaics. The statisti- cally significant relationships were investigated using lifetime and degradation

  4. Degradation Pathway Models for Photovoltaics Module Lifetime Performance

    E-Print Network [OSTI]

    Rollins, Andrew M.

    Degradation Pathway Models for Photovoltaics Module Lifetime Performance Nicholas R. Wheeler, Laura data from Underwriter Labs, featuring measurements taken on 18 identical photovoltaic (PV) modules in modules and their effects on module performance over lifetime. Index Terms--photovoltaics, statistical

  5. Correlation of Pt-Re Surface Properties with Reaction Pathways...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    with Reaction Pathways for the Aqueous-Phase Reforming of Glycerol. Abstract: The surface properties of Pt-Re catalytic nano-particles supported on carbon following exposure to a...

  6. Oscillatory Dynamics of the Extracellular Signal-regulated Kinase Pathway

    SciTech Connect (OSTI)

    Shankaran, Harish; Wiley, H. S.

    2010-12-01T23:59:59.000Z

    The extracellular signal-regulated kinase (ERK) pathway is a central signaling pathway in development and disease and is regulated by multiple negative and positive feedback loops. Recent studies have shown negative feedback from ERK to upstream regulators can give rise to biochemical oscillations with a periodicity of between 15-30 minutes. Feedback due to the stimulated transcription of negative regulators of the ERK pathway can also give rise to transcriptional oscillations with a periodicity of 1-2h. The biological significance of these oscillations is not clear, but recent evidence suggests that transcriptional oscillations participate in developmental processes, such as somite formation. Biochemical oscillations are more enigmatic, but could provide a mechanism for encoding different types of inputs into a common signaling pathway.

  7. Intersecting Fault Trends and Crustal-Scale Fluid Pathways Below...

    Open Energy Info (EERE)

    3d Magnetotelluric Surveying Jump to: navigation, search OpenEI Reference LibraryAdd to library Conference Paper: Intersecting Fault Trends and Crustal-Scale Fluid Pathways Below...

  8. Polyprenyl-dependent glycan assembly pathways in microbial pathogens

    E-Print Network [OSTI]

    Hartley, Meredith Diane

    2011-01-01T23:59:59.000Z

    Polyisoprenyl-dependent glycan assembly pathways form the basis for the biosynthesis of many complex glycoconjugates. This thesis addresses key aspects of undecaprenyl-phosphate related processes; undecaprenol is the linear ...

  9. Monitoring Long-Range Electron Transfer Pathways in Proteins...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    structure and should offer a novel window for long-range ET. Citation: Zhang Y, J Biggs, N Govind, and S Mukamel.2014."Monitoring Long-Range Electron Transfer Pathways in...

  10. Bioenergy Technologies Office R&D Pathways: Fast Pyrolysis and...

    Broader source: Energy.gov (indexed) [DOE]

    in a fluidized bed to create bio-oils, which can then be used to create hydrocarbon biofuel blendstocks. Bioenergy Technologies Office R&D Pathways: Fast Pyrolysis and...

  11. Catalytic Upgrading of Sugars to Hydrocarbons Technology Pathway

    SciTech Connect (OSTI)

    Biddy, M.; Jones, S.

    2013-03-01T23:59:59.000Z

    This technology pathway case investigates the catalytic conversion of solubilized carbohydrate streams to hydrocarbon biofuels, utilizing data from recent efforts within the National Advanced Biofuels Consortium (NABC) in collaboration with Virent, Inc. Technical barriers and key research needs that should be pursued for the catalytic conversion of sugars pathway to be competitive with petroleum-derived gasoline-, diesel-, and jet-range hydrocarbon blendstocks have been identified.

  12. Session: Avian migration and implications for wind power development in the Eastern United States

    SciTech Connect (OSTI)

    Mabey, Sarah; Cooper, Brian

    2004-09-01T23:59:59.000Z

    This session at the Wind Energy and Birds/Bats workshop consisted of two presentations followed by a discussion/question and answer period. The session was arranged to convey what is known about avian migration, particularly in the eastern US. The first presentation ''Migration Ecology: Issues of Scale and Behavior'' by Sarah Mabey frames the issue of migratory bird interactions with wind energy facilities from an ecological perspective: when, where, and why are migrant bird species vulnerable to wind turbine collision. The second presentation ''Radar Studies of Nocturnal Migration at Wind Sites in the Eastern US'' by Brian Cooper reported on radar studies conducted at wind sites in the eastern US, including Mount Storm, Clipper Wind, and others.

  13. Modeling gas and brine migration for assessing compliance of the Waste Isolation Pilot Plant

    SciTech Connect (OSTI)

    Vaughn, P. [Applied Physics, Inc., Albuquerque, NM (United States); Butcher, B. [Sandia National Labs., Albuquerque, NM (United States); Helton, J. [Arizona State Univ., Tempe, AZ (United States); Swift, P. [Tech. Reps., Inc., Albuquerque, NM (United States)

    1993-10-01T23:59:59.000Z

    At the request of the WIPP Project Integration Office (WPIO) of the DOE, the WIPP Performance Assessment (PA) Department of Sandia National Laboratories (SNL) has completed preliminary uncertainty and sensitivity analyses of gas and brine migration away from the undisturbed repository. This paper contains descriptions of the numerical model and simulations, including model geometries and parameter values, and a summary of major conclusions from sensitivity analyses. Because significant transport of contaminants can only occur in a fluid (gas or brine) medium, two-phase flow modeling can provide an estimate of the distance to which contaminants can migrate. Migration of gas or brine beyond the RCRA ``disposal-unit boundary`` or the Standard`s accessible environment constitutes a potential, but not certain, violation and may require additional evaluations of contaminant concentrations.

  14. Lglise I., 2008, Plurilinguisme et migrations en Guyane franaise , Cahiers de l'Observatoire des pratiques linguistiques, 2, Plurilinguisme et migrations, Presses Universitaire d'Orlans.

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    in the overseas Department of French Guiana. L'immigration et les mobilités de population sont constitutives du populations amérindiennes depuis près de 2000 ans, colonisation et esclavage, puis migrations économiques et immigration spontanée essentiellement du Brésil, du Surinam et d'Haïti. Le corollaire en est que cette

  15. The Kazakhs of Western Mongolia: Transnational Migration from 1990-2008

    E-Print Network [OSTI]

    Barcus, Holly; Werner, Cynthia

    2010-01-01T23:59:59.000Z

    Mongolia’; Portische, ‘Kazakh Syrmaq-Production in Western Mongolia’; Post, ‘‘‘I Take My Dombra and Sing to Remember My Homeland’’’. 33Diener, One Homeland or Two?, 184. 34Diener, Ibid., 185. 35Diener, Ibid., 186–190. 36Diener, Ibid., 176–177. 37Diener... of the most striking characteristics of this initial migration phase is the fact that a large proportion of individuals moved as part of a large kin group. In other settings, it is not uncommon for families to migrate together. What is unique about the Kazakh...

  16. Management intensity alters decomposition via biological pathways

    E-Print Network [OSTI]

    Cleveland, Cory

    exhibited strong responses to both litter and management type. Overall, our results indicate than at any time in the past 60 years (USDA 2009), and the continued demand for productive agricultural that enhance ecosystem services including water, nutrient, and organic matter retention (Lal et al. 2004

  17. Hydraulic Characteristics of the Lower Snake River During Periods of Juvenile Fall Chinook Migration

    SciTech Connect (OSTI)

    Cook, Chris B.; Dibrani, Berhon; Richmond, Marshall C.; Bleich, Matthew D.; Titzler, P. Scott; Fu, Tao

    2006-01-30T23:59:59.000Z

    This report documents a four-year study to assess hydraulic conditions in the lower Snake River. The work was conducted for the Bonneville Power Administration, U.S. Department of Energy, by the Pacific Northwest National Laboratory. Cold water released from the Dworshak Reservoir hypolimnion during mid- to late-summer months cools the Clearwater River far below equilibrium temperature. The volume of released cold water augments the Clearwater River, and the combined total discharge is on the order of the Snake River discharge when the two rivers meet at their confluence near the upstream edge of Lower Granite Reservoir. With typical temperature differences between the Clearwater and Snake rivers of 10°C or more during July and August, the density difference between the two rivers during summer flow augmentation periods is sufficient to stratify Lower Granite Reservoir as well as the other three reservoirs downstream. Because cooling of the river is desirable for migrating juvenile fall Chinook salmon (Oncorhynchus tshawytscha) during this same time period, the amount of mixing and cold water entrained into Lower Granite Reservoir’s epilimnion at the Clearwater/Snake River confluence is of key biological importance to juvenile fall Chinook salmon. Data collected during this project indicates the three reservoirs downstream of Lower Granite also stratify as direct result of flow augmentation from Dworshak Reservoir. These four lower Snake reservoirs are also heavily influenced by wind forcing at the water’s surface, and during periods of low river discharge, often behave like a two-layer lake. During these periods of stratification, lower river discharge, and wind forcing, the water in the upper layer of the reservoir is held in place or moves slightly upstream. This upper layer is also exposed to surface heating and may warm up to temperatures close to equilibrium temperature. The depth of this upper warm layer and its direction of travel may also be of key biological importance to juvenile fall Chinook salmon. This report describes field data collection, modeling, and analysis of hydrodynamic and temperature conditions in the Lower Granite Reservoir during the summer flow augmentation periods of 2002, 2003, and 2004 plus a brief one-week period in 2005 of Lower Monumental, Little Goose, and Lower Granite Reservoirs. Circulation patterns in all four lower Snake River reservoirs were numerically simulated for periods of 2002, 2003, 2004, and 2005 using CE-QUAL-W2. Simulation results show that these models are sufficiently capable of matching diurnal and long term temperature and velocity changes in the reservoirs. In addition, the confluence zone of the Clearwater and Snake rivers was modeled using the 3-D model Flow3-D. This model was used to better understand mixing processing and entrainment. Once calibrated and validated, the reservoir models were used to investigate downstream impacts of alternative reservoir operation schemes, such as increasing or decreasing the ratio of Clearwater to Snake discharge. Simulation results were also linked with the particle tracking model FINS to better understand alterations of integrated metrics due to alternative operation schemes. These findings indicate that significant alterations in water temperature throughout the lower Snake River are possible by altering hypolimnetic discharges from Dworshak Reservoir and may have a significant impact on the behavior of migrating juvenile fall Chinook salmon during periods of flow augmentation.

  18. Comparative Survival Study (CSS) of Hatchery PIT-tagged Spring/Summer Chinook; Migration Years 1997-2000 Mark/Recapture Activities, 2001 Annual Report.

    SciTech Connect (OSTI)

    Bouwes, Nick (EcoLogical Research, Providence, UT); Petrosky, Charlie (Idaho Department of Fish and Game, Boise ID); Schaller, Howard (US Fish and Wildlife Service, Columbia River Fisheries Program Office, Vancouver, WA)

    2002-02-01T23:59:59.000Z

    The Comparative Survival Study (CSS) was initiated in 1996 as a multi-year program of the fishery agencies and tribes to estimate survival rates over different life stages for spring and summer chinook (hereafter, chinook) produced in major hatcheries in the Snake River basin and from selected hatcheries in the lower Columbia River. Much of the information evaluated in the CSS is derived from fish tagged with Passive Integrated Transponder (PIT) tags. A comparison of survival rates of chinook marked in two different regions (which differ in the number of dams chinook have to migrate through) provides insight into the effects of the Snake/Columbia hydroelectric system (hydrosystem). The CSS also compares the smolt-to-adult survival rates (SARs) for Snake River chinook that were transported versus those that migrated in-river to below Bonneville Dam. Additional comparisons can be made within in-river experiences as well comparison between the different collector projects from which smolts are transported. CSS also compares these survival rates for wild Snake River spring and summer chinook. These comparisons generate information regarding the relative effects of the current management actions used to recover this listed species.Scientists and managers have recently emphasized the importance of delayed hydrosystem mortality to long-term management decisions. Delayed hydrosystem mortality may be related to the smolts. experience in the Federal Columbia River Power System, and could occur for both smolts that migrate in-river and smolts that are transported. The CSS PIT tag information on in-river survival rates and smolt-to-adult survival rates (SARs) of transported and in-river fish are relevant to estimation of ''D'', which partially describes delayed hydrosystem mortality. ''D'', or differential delayed mortality, is the differential survival rate of transported fish relative to fish that migrate in-river, as measured from below Bonneville Dam to adults returning to Lower Granite Dam. A ''D'' equal to one indicates that there is no difference in survival rate after hydrosystem passage, while a ''D'' less than one indicates that transported smolts die at a greater rate after release, than smolts that have migrated through the hydrosystem. While the relative survival rates of transported and in-river migrants are important, the SARs must be also be sufficient to allow the salmon to persist and recover (Mundy et al. 1994). Decreased SARs could result from delayed hydrosystem mortality for either transported or in-river migrants, or both. Major objectives of CSS include: (1) development of a long-term index of transport SAR to in-river SAR for Snake River hatchery spring and summer chinook smolts measured at Lower Granite Dam; (2) develop a long-term index of survival rates from release of smolts at Snake River hatcheries to return of adults to the hatcheries; (3) compute and compare the overall SARs for selected upriver and downriver spring and summer chinook hatcheries; (4) begin a time series of SARs for use in hypothesis testing and in the regional long-term monitoring and evaluation program; (5) evaluate growth patterns of transported and in-river migrating smolts, and of upriver and downriver stocks. Primary CSS focus in this report for the 1997-1999 migration years included hatchery chinook tasks for objectives 1, 4 and 5.

  19. Transport and transportation pathways of hazardous chemicals from solid waste disposal. Environ. Health Perspect

    E-Print Network [OSTI]

    Robert Van Hook

    1978-01-01T23:59:59.000Z

    To evaluate the impact of hazardous chemicals in solid wastes on man and other organisms, it is necessary to have information about amounts of chemical present, extent of exposure, and chemical toxicity. This paper addresses the question of organism exposure by considering the major physical and biological transport pathways and the physicochemical and biochemical transformations that may occur in sediments, soils, and water. Disposal of solid wastes in both terrestrial and oceank environments is considered. Atmospheric transport is considered for emissions from incineration of solid wastes and for wind resuspension of particulates from surface waste deposits. Solid wastes deposited in terrestrial environments are subject to leaching by surface and ground waters. Leachates may then be transported to other surface waters and drinking water aquifers through hydrologic transport. Leachates also interact with natural organic matter, clays, and microorganisms in soils and sediments. These interactions may render chemical constituents in leachates more or less mobile, possibly change chemical and physical forms, and alter their biological activity. Oceanic waste disposal practices result in migration through diffusion and ocean currents. Surface area-to-volume ratios play a major role in the initial distributions of chemicals in the aquatic environment. Sediments serve as major sources and sinks of chemical contaminants. Food chain transport in both aquatic and terrestrial environments results in the movement of hazardous chemicals from lower to higher positions in the food web. Bioconcentration is observed in both terrestrial and aquatic food chains with certain elements and synthetic organics. Bioconcentration factors tend to be higher for synthetic organics, and higher in aquatic than in terrestrial systems. Biodilution is not atypical in terrestrial environments. Synergistic and antagonistic actions are common occurrences among chemical contaminants and can be particularly important toxicity considerations in aquatic environments receiving runoff from several terrestrial sources.

  20. Polyferrocenylsilanes as Protective Charge Migration Coatings for Dielectrics*

    E-Print Network [OSTI]

    Balmain, Keith G.

    from a concentrated toluene solution coated on Mylar did not experience any arc discharging when exposed to a beam of low energy (20 keV) electrons for a 1 h time period. In order to further investigate beneath a circular mask and exposed to a low energy electron flux (5­25 keV), measurements of the current

  1. Transportation Energy Futures Series: Vehicle Technology Deployment Pathways: An Examination of Timing and Investment Constraints

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron Spin Transition in2, 2003Toolsearch keywordsclearLIGHT-DUTY VEHICLES

  2. Cs deposition and vertical migration in soils from Argentina J. Juri Ayub, M. Rizzotto, J. Toso, H. Velasco

    E-Print Network [OSTI]

    Nacional de San Luis, Universidad

    1 137 Cs deposition and vertical migration in soils from Argentina J. Juri Ayub, M. Rizzotto, J), Universidad Nacional de San Luis. CONICET. Ejército de los Andes 950, 5700 San Luis, Argentina Abstract. Vertical migration of 137 Cs global fallout was studied in soils from Argentina. The sampling area

  3. State of the art: CDF contaminant pathway control

    SciTech Connect (OSTI)

    Richardson, G.N. [G.N. Richardson and Associates, Raleigh, NC (United States); Petrovski, D.M. [Environmental Protection Agency, Chicago, IL (United States). CERCLA Div.; Chaney, R.C. [Humbolt State Univ., Arcata, CA (United States); Demars, K.R. [Univ. of Connecticut, Storrs, CT (United States)

    1995-12-31T23:59:59.000Z

    Within the US, about 400 million cubic yards (520 million cubic meters) of sediments are dredged annually (COE 1987). Sediment is the material that settles to the bottom of a body of water and includes soil particles consisting of clays, silts, and sands; organic matter; shells; and residuals from industrial discharges, which can include organics and heavy metals. Contaminants from sediments contained within a confined disposal facility (CDF) can be discharged to the environment via six potential pathways. These pathways include three waterborne pathways, the direct uptake of the contaminants by plants or animals, and airborne emission of contaminants. Conventional CDF design focuses on retention of sediment particles with perimeter dikes. Depending upon the nature of the site, the contaminants of concern, method of dredging, physical properties of the dredged material, operational aspects, and many other factors, including socio-political factors, supplemental environmental design criteria may be required for the CDF. This paper reviews design alternatives to control contaminant loss from the CDF basin through the six identified contaminant pathways. These alternatives include the use of both additional design components ad operational constraints. The need for a specific pathway control measure is shown to depend on both site and sediment specific evaluation criteria.

  4. Developmental defects in zebrafish for classification of EGF pathway inhibitors

    SciTech Connect (OSTI)

    Pruvot, Benoist; Curé, Yoann; Djiotsa, Joachim; Voncken, Audrey; Muller, Marc, E-mail: m.muller@ulg.ac.be

    2014-01-15T23:59:59.000Z

    One of the major challenges when testing drug candidates targeted at a specific pathway in whole animals is the discrimination between specific effects and unwanted, off-target effects. Here we used the zebrafish to define several developmental defects caused by impairment of Egf signaling, a major pathway of interest in tumor biology. We inactivated Egf signaling by genetically blocking Egf expression or using specific inhibitors of the Egf receptor function. We show that the combined occurrence of defects in cartilage formation, disturbance of blood flow in the trunk and a decrease of myelin basic protein expression represent good indicators for impairment of Egf signaling. Finally, we present a classification of known tyrosine kinase inhibitors according to their specificity for the Egf pathway. In conclusion, we show that developmental indicators can help to discriminate between specific effects on the target pathway from off-target effects in molecularly targeted drug screening experiments in whole animal systems. - Highlights: • We analyze the functions of Egf signaling on zebrafish development. • Genetic blocking of Egf expression causes cartilage, myelin and circulatory defects. • Chemical inhibition of Egf receptor function causes similar defects. • Developmental defects can reveal the specificity of Egf pathway inhibitors.

  5. Charge Migration Efficiency Optimization in Hybrid Electrical Energy Storage (HEES) Systems

    E-Print Network [OSTI]

    Pedram, Massoud

    Charge Migration Efficiency Optimization in Hybrid Electrical Energy Storage (HEES) Systems the excessive electric energy in the electrical energy storage (EES) rather than converting into a different) are typically not balanced with each other. Storage of excessive en- ergy and compensation of the energy

  6. Multiple-Source and Multiple-Destination Charge Migration in Hybrid Electrical Energy Storage Systems*

    E-Print Network [OSTI]

    Pedram, Massoud

    Multiple-Source and Multiple-Destination Charge Migration in Hybrid Electrical Energy Storage massimo.poncino@polito.it Abstract-- Hybrid electrical energy storage (HEES) systems consist of multiple banks of heterogeneous electrical energy storage (EES) elements that are connected to each other through

  7. Efficient Data Migration to Conserve Energy in Streaming Media Storage Systems

    E-Print Network [OSTI]

    Qin, Xiao

    Efficient Data Migration to Conserve Energy in Streaming Media Storage Systems Yunpeng Chai, Zhihui. Existing energy conservation techniques are inadequate to achieve high energy efficiency for streaming in this paper a new energy-efficient method called Explicit Energy Saving Disk Cooling or EESDC. EESDC

  8. Migration of seismicity and earthquake interactions monitored by GPS in SE Asia triple junction: Sulawesi, Indonesia

    E-Print Network [OSTI]

    McCaffrey, Robert

    : Sulawesi, Indonesia Christophe Vigny,1 Hugo Perfettini,1,2 Andrea Walpersdorf,1,2 Anne Lemoine1 Wim Simons] Global Positioning System (GPS) measurements made in Sulawesi, Indonesia, from 1992 to 1999 detected, fault, fluids, seismotectonics, earthquake, Indonesia Citation: Vigny, C., et al., Migration

  9. Hydrogen Bond Migration between Molecular Sites Observed with Ultrafast 2D IR Chemical Exchange Spectroscopy

    E-Print Network [OSTI]

    Fayer, Michael D.

    Hydrogen Bond Migration between Molecular Sites Observed with Ultrafast 2D IR Chemical ExchangeVed: January 12, 2010 Hydrogen-bonded complexes between phenol and phenylacetylene are studied using ultrafast hydrogen bonding acceptor sites (phenyl or acetylene) that compete for hydrogen bond donors in solution

  10. ORBITAL MIGRATION OF INTERACTING LOW-MASS PLANETS IN EVOLUTIONARY RADIATIVE TURBULENT MODELS

    SciTech Connect (OSTI)

    Horn, Brandon; Mac Low, Mordecai-Mark [Department of Astronomy, Columbia University, 550 West 120th St, New York, NY 10027 (United States); Lyra, Wladimir [Department of Astrophysics, American Museum of Natural History, 79th Street at Central Park West, New York, NY 10024 (United States); Sandor, Zsolt, E-mail: bhorn@astro.columbia.edu, E-mail: wlyra@amnh.org, E-mail: mordecai@amnh.org, E-mail: zsolt.sandor@uibk.ac.at [Max-Planck-Institut fuer Astronomie, Koenigstuhl 17, 69117, Heidelberg (Germany)

    2012-05-01T23:59:59.000Z

    The torques exerted by a locally isothermal disk on an embedded planet lead to rapid inward migration. Recent work has shown that modeling the thermodynamics without the assumption of local isothermality reveals regions where the net torque on an embedded planet is positive, leading to outward migration of the planet. When a region with negative torque lies directly exterior to this, planets in the inner region migrate outward and planets in the outer region migrate inward, converging where the torque is zero. We incorporate the torques from an evolving non-isothermal disk into an N-body simulation to examine the behavior of planets or planetary embryos interacting in the convergence zone. We find that mutual interactions do not eject objects from the convergence zone. Small numbers of objects in a laminar disk settle into near resonant orbits that remain stable over the 10 Myr periods that we examine. However, either or both increasing the number of planets or including a correlated, stochastic force to represent turbulence drives orbit crossings and mergers in the convergence zone. These processes can build gas giant cores with masses of order 10 Earth masses from sub-Earth mass embryos in 2-3 Myr.

  11. Migration of Earth-size planets in 3D radiative discs

    E-Print Network [OSTI]

    Lega, E; Bitsch, B; Morbidelli, A

    2014-01-01T23:59:59.000Z

    In this paper, we address the migration of small mass planets in 3D radiative disks. Indeed, migration of small planets is known to be too fast inwards in locally isothermal conditions. However, thermal effects could reverse its direction, potentially saving planets in the inner, optically thick parts of the protoplanetary disc. This effect has been seen for masses larger than 5 Earth masses, but the minimum mass for this to happen has never been probed numerically, although it is of crucial importance for planet formation scenarios. We have extended the hydro-dynamical code FARGO to 3D, with thermal diffusion. With this code, we perform simulations of embedded planets down to 2 Earth masses. For a set of discs parameters for which outward migration has been shown in the range of $[5, 35]$ Earth masses, we find that the transition to inward migration occurs for masses in the range $[3, 5]$ Earth masses. The transition appears to be due to an unexpected phenomenon: the formation of an asymmetric cold and dense...

  12. Thymosin {beta}4 promotes the migration of endothelial cells without intracellular Ca{sup 2+} elevation

    SciTech Connect (OSTI)

    Selmi, Anna [Department of Molecular and Medical Biophysics, Medical University of Lodz, 92-215 Lodz (Poland)] [Department of Molecular and Medical Biophysics, Medical University of Lodz, 92-215 Lodz (Poland); Malinowski, Mariusz [Institute of Medical Biology, Polish Academy of Sciences, Lodz (Poland)] [Institute of Medical Biology, Polish Academy of Sciences, Lodz (Poland); Brutkowski, Wojciech [Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw (Poland)] [Nencki Institute of Experimental Biology, Polish Academy of Sciences, 02-093 Warsaw (Poland); Bednarek, Radoslaw [Department of Molecular and Medical Biophysics, Medical University of Lodz, 92-215 Lodz (Poland)] [Department of Molecular and Medical Biophysics, Medical University of Lodz, 92-215 Lodz (Poland); Cierniewski, Czeslaw S., E-mail: czeslaw.cierniewski@umed.lodz.pl [Department of Molecular and Medical Biophysics, Medical University of Lodz, 92-215 Lodz (Poland); Institute of Medical Biology, Polish Academy of Sciences, Lodz (Poland)

    2012-08-15T23:59:59.000Z

    Numerous studies have demonstrated the effects of T{beta}4 on cell migration, proliferation, apoptosis and inflammation after exogenous treatment, but the mechanism by which T{beta}4 functions is still unclear. Previously, we demonstrated that incubation of endothelial cells with T{beta}4 induced synthesis and secretion of various proteins, including plasminogen activator inhibitor type 1 and matrix metaloproteinases. We also showed that T{beta}4 interacts with Ku80, which may operate as a novel receptor for T{beta}4 and mediates its intracellular activity. In this paper, we provide evidence that T{beta}4 induces cellular processes without changes in the intracellular Ca{sup 2+} concentration. External treatment of HUVECs with T{beta}4 and its mutants deprived of the N-terminal tetrapeptide AcSDKP (T{beta}4{sub AcSDKPT/4A}) or the actin-binding sequence KLKKTET (T{beta}4{sub KLKKTET/7A}) resulted in enhanced cell migration and formation of tubular structures in Matrigel. Surprisingly, the increased cell motility caused by T{beta}4 was not associated with the intracellular Ca{sup 2+} elevation monitored with Fluo-4 NW or Fura-2 AM. Therefore, it is unlikely that externally added T{beta}4 induces HUVEC migration via the surface membrane receptors known to generate Ca{sup 2+} influx. Our data confirm the concept that externally added T{beta}4 must be internalized to induce intracellular mechanisms supporting endothelial cell migration.

  13. Mortality of bats at wind turbines links to nocturnal insect migration?

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    REVIEW Mortality of bats at wind turbines links to nocturnal insect migration? Jens Rydell & Lothar mortality data from wind farms in Europe (published elsewhere). We suggest that mortality of bats at wind. It is supported by the observation that mortality of bats at wind turbines is highly seasonal (August

  14. UserCalc: A Web-based uranium series calculator for magma migration problems

    E-Print Network [OSTI]

    Spiegelman, Marc W.

    UserCalc: A Web-based uranium series calculator for magma migration problems M. Spiegelman Lamont] Abstract: Measured departures from secular equilibrium in the uranium series decay chains provide important U3231 Pa) and allow the user to input their own petrological insight and data to explore

  15. UserCalc: a web-based Uranium Series Calculator for magma migration problems

    E-Print Network [OSTI]

    Spiegelman, Marc W.

    UserCalc: a web-based Uranium Series Calculator for magma migration problems M. Spiegelman Lamont. Measured departures from secular equilibrium in the Uranium-series decay chains provide important to explore the behaviour of this model. The purpose of the site is to provide a tool that can spur additional

  16. Synchronized Co-migration of Virtual Machines for IDS Offloading in Clouds Kenichi Kourai Hisato Utsunomiya

    E-Print Network [OSTI]

    Kourai, Kenichi

    of the users. However, offloaded IDSes cannot continue to monitor their target VM when the VM is migrated that a guard VM always monitors its target VM while the target VM is running. We have implemented VMCoupler offloading with VM introspection [1]. This technique enables IDSes to run in the outside of their target VM

  17. Stability and Migration of Charged Oxygen Interstitials in ThO2...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    oxygen interstitial mobility in ThO2 than in CeO2. Citation: Xiao HY, Y Zhang, and WJ Weber.2013."Stability and Migration of Charged Oxygen Interstitials in ThO2 and CeO2."Acta...

  18. Minimizing the Population Extinction Risk by Migration Michael Khasin,1,2

    E-Print Network [OSTI]

    Meerson, Baruch

    ­3]. Habitat fragmentation is implicated in the decline and extinction of many endangered species [4Minimizing the Population Extinction Risk by Migration Michael Khasin,1,2 Baruch Meerson,3 Evgeniy occupying separate patches. A local population is prone to extinction due to the shot noise of birth

  19. Monitoring the Migrations of Wild Snake River Spring and Summer Chinook Salmon Smolts, 1992 Annual Report.

    SciTech Connect (OSTI)

    Achord, Stephen; Marsh, Douglas M.; Kamikawa, Daniel J. (Northwest and Alaska Fisheries Center, Coastal Zone and Estuarine Division, Seattle, WA)

    1994-09-01T23:59:59.000Z

    We PIT tagged wild spring and summer chinook salmon parr in the Snake River Basin in 1991, and subsequently monitored these fish during their smolt migration through Lower Granite, Little Goose, and McNary Dams during spring and summer 1992. This report details our findings.

  20. Novel methods reveal shifts in migration phenology of barn swallows in South Africa

    E-Print Network [OSTI]

    de Villiers, Marienne

    1 Novel methods reveal shifts in migration phenology of barn swallows in South Africa Res Altwegg National Biodiversity Institute, P/Bag X7, Claremont 7735, South Africa Animal Demography Unit, Department of Zoology and Department of Statistical Sciences, University of Cape Town, Rondebosch 7701, South Africa

  1. A prediction of meander migration based on large-scale flume tests in clay

    E-Print Network [OSTI]

    Park, Namgyu

    2009-05-15T23:59:59.000Z

    great ideas or useful hints for new research concerning the same type of problem. The past research works related to the prediction of meander migration were studied in order to have a better understanding of the existing techniques and an idea of a...

  2. An Empirical Study on the Fault-Proneness of Clone Migration in Clone Genealogies

    E-Print Network [OSTI]

    Zou, Ying

    An Empirical Study on the Fault-Proneness of Clone Migration in Clone Genealogies Shuai Xie1 genealogy. During the evolution of a clone group, developers may change the location of the code fragments the risk for faults in clone segments, clone groups, and clone genealogies from three long-lived software

  3. A Network Model for The Genesis and Migration of Gas Phase

    E-Print Network [OSTI]

    New York at Stoney Brook, State University of

    flow (below local bubble point conditions) as well as the genesis and migration of the gas phase when bubble point conditions are achieved locally. Computational tests with and without gravity were run genesis, carbon dioxide sequestration, compositional flow AMS subject classification: 65C20, 68U20, 76Q05

  4. Distributed Task Migration for Thermal Management in Many-core Systems

    E-Print Network [OSTI]

    Qiu, Qinru

    chip complexity and power envelope elevate peak temperatures of chip and imbalance the thermal gradientDistributed Task Migration for Thermal Management in Many-core Systems Yang Ge, Parth Malani, Qinru York {yge2, pmalani1, qqiu}@binghamton.edu ABSTRACT In the deep submicron era, thermal hot spots

  5. Dynamics of a fishery on two fishing zones with fish stock dependent migrations: aggregation and control

    E-Print Network [OSTI]

    Bravo de la Parra, Rafael

    Dynamics of a fishery on two fishing zones with fish stock dependent migrations: aggregation a specific stock-effort dynamic model. The stock corresponds to two fish populations growing and moving between two fishing zones, on which they are harvested by two different fleets. The effort represents

  6. 1,2-Sulfanyl Group Migration as a Driving Force: New Approach to

    E-Print Network [OSTI]

    Wang, Jianbo

    ) For general reviews on pyrroles, see: (a) Jones, R. A. In Pyrroles, Part II, The Synthesis, Reacti. Chem. 2001, 66, 4058. (4) For reviews on pyrrole synthesis, see: (a) Sundberg, R. J. In Comprehensi1,2-Sulfanyl Group Migration as a Driving Force: New Approach to Pyrroles by Reaction of Allenic

  7. Gender-specific out-migration, deforestation and urbanization in the Ecuadorian Amazon

    E-Print Network [OSTI]

    Lopez-Carr, David

    Gender-specific out-migration, deforestation and urbanization in the Ecuadorian Amazon Alisson F rates of deforestation of any Amazonian nation. Most of this forest elimination has been caused on deforestation, urbanization and regional development, population mobility within the Amazon has hardly been

  8. The notion of social networks in migration by Marie-Antoinette Hily1

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    The notion of « social networks » in migration by Marie-Antoinette Hily1 , William Berthomière2/Poitiers(UMR Miti-CNRS). 3 Associated researcher , Compas (Oxford University). 1 #12;The notion of « social networks", Kapferer, B. (1973) "Social networks and conjugal role" in Jeremy Boissevain and Clyde Mitchell (eds

  9. CONSIDERATION OF THREE PROPOSED MODELS OF THE MIGRATION OF YOUNG SKIPJACK TUNA (KATSUWONUS PELAMIS)

    E-Print Network [OSTI]

    CONSIDERATION OF THREE PROPOSED MODELS OF THE MIGRATION OF YOUNG SKIPJACK TUNA (KATSUWONUS PELAMIS (KatsuUJonus pelamis) in in the eastern Pacific Ocean have a central racific spawning origin. Three (Katsuwonus pelamis) are widely distributed in tropical and subtropical surface waters of world oceans

  10. Oxygen sublattice defect in cobalt oxide : formation, migration, charge localization and thermodynamic processes

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    643 Oxygen sublattice defect in cobalt oxide : formation, migration, charge localization of oxygen defects in CoO using classical simulations. The charge localization in the oxygen vacancy has]. The defect concentration in the oxygen sublattice is several orders of magnitude smaller, but never- theless

  11. The New West: Patterns of Internal Migration at the Beginning of the 21st Century

    E-Print Network [OSTI]

    Meyer, Leslie Denise

    2012-02-14T23:59:59.000Z

    . This dissertation utilized data from the United States Bureau of the Census‘ County and City Data Book: 2007 and other sources to analyze migration patterns at the structural-contextual level and the individual-level in the New West. At the structural...

  12. Gas injection to inhibit migration during an in situ heat treatment process

    DOE Patents [OSTI]

    Kuhlman, Myron Ira (Houston, TX); Vinegar; Harold J. (Bellaire, TX); Baker, Ralph Sterman (Fitchburg, MA); Heron, Goren (Keene, CA)

    2010-11-30T23:59:59.000Z

    Methods of treating a subsurface formation are described herein. Methods for treating a subsurface treatment area in a formation may include introducing a fluid into the formation from a plurality of wells offset from a treatment area of an in situ heat treatment process to inhibit outward migration of formation fluid from the in situ heat treatment process.

  13. Fracturing controlled primary migration of hydrocarbon fluids during1 heating of organic-rich shales2

    E-Print Network [OSTI]

    understand primary migration of16 hydrocarbon fluids in very low permeability source rock. Cracks nucleate.e. the transport of hydrocarbon fluids from extremely low39 permeability source rocks in which they are generated the source rock is42 formed is buried, the organic material is transformed into complex high molecular weight

  14. Fluorine-19 MRI for Visualization and Quantification of Cell Migration in a Diabetes Model

    E-Print Network [OSTI]

    Laidlaw, David

    Fluorine-19 MRI for Visualization and Quantification of Cell Migration in a Diabetes Model Mangala the nonobese dia- betic mouse, an established model of type 1 diabetes, 19F MRI data were acquired showing Med 58: 725­734, 2007. © 2007 Wiley-Liss, Inc. Key words: T cells; diabetes; MRI; cell tracking

  15. EFFECT OF BENTONITE MIGRATION IN GEOSYNTHETIC CLAY LINERS ON CONTAMINANT TRANSPORT

    E-Print Network [OSTI]

    1 EFFECT OF BENTONITE MIGRATION IN GEOSYNTHETIC CLAY LINERS ON CONTAMINANT TRANSPORT T. D. Stark1.ca.gov ABSTRACT: Since the introduction of geosynthetic clay liners (GCLs) to waste containment facilities, one contaminant transport through a GCL. 1 INTRODUCTION In recent years, geosynthetic clay liners (GCLs

  16. Geosynthetics International, 2004, 11, No. 4 Occurrence and effect of bentonite migration in

    E-Print Network [OSTI]

    in geosynthetic clay liners T. D. Stark1 , H. Choi2 and R. Akhtarshad3 1 Professor, Department of Civil the introduction of geosynthetic clay liners (GCLs) to waste containment facilities, one of the major concerns. & Akhtarshad, R. (2004). Occurrence and effect of bentonite migration in geosynthetic clay liners

  17. Geochemical studies of crude oil generation, migration, and destruction in Mississippi salt basin

    SciTech Connect (OSTI)

    Sassen, R.; Moore, C.H.; Nunn, J.A.; Meendsen, F.C.; Heydari, E.

    1987-09-01T23:59:59.000Z

    The main source for crude oil in the Mississippi salt basin is the laminated lime mudstone facies of the lower Smackover. Crude oil generation and migration commenced at a level of thermal maturity equivalent to about 0.55% vitrinite reflectance. Short-range lateral migration of crude oil was focused on upper Smackover and Norphlet reservoirs, but vertical migration also charged some overlying Cotton Valley, Rodessa, lower Tuscaloosa, and Eutaw reservoirs. Following migration from the lower Smackover, thermal maturity history of reservoir rocks controls the preservation of crude oil, gas condensate, and methane. Slow thermal cracking of crude oil occurred in deep upper Smackover reservoirs, resulting in formation of gas condensate and precipitation of solid bitumen. The maximum thermal maturity for preservation of condensate is equivalent to about 1.3% vitrinite reflectance. Only methane, pyrobitumen, and nonhydrocarbon gases, including hydrogen sulfide, persist at higher levels of thermal maturity. Early destruction of methane in deep upper Smackover reservoirs near the Wiggins arch is driven by thermochemical sulfate reduction. Lesser availability of sulfate in Norphlet reservoirs could account for methane preservation at higher levels of thermal maturity. One basic geochemical strategy for further exploration of the Mississippi salt basin is to focus exploration effort on traps with reservoirs in the thermal maturity window for hydrocarbon preservation. Another strategy is to avoid drilling traps with overmature reservoir rocks.

  18. Numerical methods for the simulation of salt migration in regional groundwater

    E-Print Network [OSTI]

    Vuik, Kees

    Numerical methods for the simulation of salt migration in regional groundwater flow E.S. van Baaren #12;Contents 1 Introduction 1 2 Model description 3 2.1 Basic Assumptions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 3.2 Finite Elements . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 3.2.1 Grid

  19. Behaviour and thermal experience of adult sockeye salmon migrating through stratified

    E-Print Network [OSTI]

    Cooke, Steven J.

    entirely by endogenous energy reserves as individuals cease feeding before leaving the ocean en routeBehaviour and thermal experience of adult sockeye salmon migrating through stratified lakes near water temperatures by utilising thermal refugia in cool-water tributaries (Berman & Quinn 1991; Goniea

  20. Functional significance of octameric RuvA for a branch migration complex from Thermus thermophilus

    SciTech Connect (OSTI)

    Fujiwara, Yoshie [Graduate School of Engineering Science, Osaka University, 1-3, Machikaneyama, Toyonaka, Osaka 560-8531 (Japan); Mayanagi, Kouta [Nagahama Institute of Bio-Science and Technology, 1266 Tamura-cho, Nagahama, Shiga 526-0829 (Japan); The Takara-Bio Endowed Division, Institute for Protein Research, Osaka University, 6-2-3, Furuedai, Suita, Osaka 565-0874 (Japan); JST-BIRD, Nagahama 526-0829 (Japan); Morikawa, Kosuke [The Takara-Bio Endowed Division, Institute for Protein Research, Osaka University, 6-2-3, Furuedai, Suita, Osaka 565-0874 (Japan); CREST, JST, Sanban-cho, Chiyoda-ku, Tokyo 102-0075 (Japan)], E-mail: morikako@protein.osaka-u.ac.jp

    2008-02-08T23:59:59.000Z

    The RuvAB complex promotes migration of Holliday junction at the late stage of homologous recombination. The RuvA tetramer specifically recognizes Holliday junction to form two types of complexes. A single tetramer is bound to the open configuration of the junction DNA in complex I, while the octameric RuvA core structure sandwiches the same junction in complex II. The hexameric RuvB rings, symmetrically bound to both sides of RuvA on Holliday junction, pump out DNA duplexes, depending upon ATP hydrolysis. We investigated functional differences between the wild-type RuvA from Thermus thermophilus and mutants impaired the ability of complex II formation. These mutant RuvA, exclusively forming complex I, reduced activities of branch migration and ATP hydrolysis, suggesting that the octameric RuvA is essential for efficient branch migration. Together with our recent electron microscopic analysis, this finding provides important insights into functional roles of complex II in the coordinated branch migration mechanism.

  1. Damage Characterization of the Z24 Bridge by Transfer Function Pole Migration R. Andrew Swartz1

    E-Print Network [OSTI]

    Lynch, Jerome P.

    Damage Characterization of the Z24 Bridge by Transfer Function Pole Migration R. Andrew Swartz1 , Jerome P. Lynch2 1 PhD Candidate, Department of Civil and Environmental Engineering, University of Michigan, Ann Arbor, MI 48109 2 Assistant Professor, Department of Civil and Environmental Engineering

  2. Like all other vertebrates, fish need time to recover after exhaustive activity. Furthermore, a rapid rate of recovery may

    E-Print Network [OSTI]

    Farrell, Anthony P.

    Like all other vertebrates, fish need time to recover after exhaustive activity. Furthermore. For example, a rapid rate of recovery is needed to keep migratory passage timely when adult salmon use of anaerobic swimming because the entire upstream migration is completed using stored energy reserves

  3. Roaming dynamics in ion-molecule reactions: phase space reaction pathways and geometrical interpretation

    E-Print Network [OSTI]

    F. A. L. Mauguière; P. Collins; G. S. Ezra; S. C. Farantos; S. Wiggins

    2014-01-31T23:59:59.000Z

    A model Hamiltonian for the reaction CH$_4^+ \\rightarrow$ CH$_3^+$ + H, parametrized to exhibit either early or late inner transition states, is employed to investigate the dynamical characteristics of the roaming mechanism. Tight/loose transition states and conventional/roaming reaction pathways are identified in terms of time-invariant objects in phase space. These are dividing surfaces associated with normally hyperbolic invariant manifolds (NHIMs). For systems with two degrees of freedom NHIMS are unstable periodic orbits which, in conjunction with their stable and unstable manifolds, unambiguously define the (locally) non-recrossing dividing surfaces assumed in statistical theories of reaction rates. By constructing periodic orbit continuation/bifurcation diagrams for two values of the potential function parameter corresponding to late and early transition states, respectively, and using the total energy as another parameter, we dynamically assign different regions of phase space to reactants and products as well as to conventional and roaming reaction pathways. The classical dynamics of the system are investigated by uniformly sampling trajectory initial conditions on the dividing surfaces. Trajectories are classified into four different categories: direct reactive and non reactive trajectories,which lead to the formation of molecular and radical products respectively, and roaming reactive and non reactive orbiting trajectories, which represent alternative pathways to form molecular and radical products. By analysing gap time distributions at several energies we demonstrate that the phase space structure of the roaming region, which is strongly influenced by non-linear resonances between the two degrees of freedom, results in nonexponential (nonstatistical) decay.

  4. Tritium hazard via the ingestion pathway

    SciTech Connect (OSTI)

    Travis, C.C.

    1985-01-01T23:59:59.000Z

    The classic methodology for estimating dose to man from environmental tritium ignores the fact that organically bound tritium in foodstuffs may be directly assimilated in the bound compartment of tissues without previous oxidation. We propose a four-compartment model that allows for the ability to input organically bound tritium in foodstuffs directly into the organic compartments of the model. We found that organically bound tritium in foodstuffs can increase the total body dose by a factor of 1.7 to 4.5 times the free body water dose alone, depending on the bound to loose ratio of tritium in the diet. 10 refs., 1 fig., 1 tab.

  5. Migration and Directional Change of Interstitial Clusters in ?-Fe: Searching for Transition States by the Dimer Method

    SciTech Connect (OSTI)

    Gao, Fei; Heinisch, Howard L.; Kurtz, Richard J.; Osetsky, Yuri N.; Hoagland, Richard G.

    2005-02-01T23:59:59.000Z

    The interstitial clusters produced by cascades in metals have very high mobility and exhibit thermally activated, one-dimensional glide along the crowdion direction, as revealed by molecular dynamics (MD) simulations. Only small interstitial clusters (<4) are observed to change their glide direction during the period of MD simulations ({approx} 10 ns), but the directional change for larger clusters is inaccessible to MD due to the limited time-scale. In order to overcome the ''time barrier'' in MD simulations, the dimer method is employed to search for possible transition states of interstitials and small interstitial clusters in alpha-Fe. The method uses only the first derivatives of the potential energy to find saddle points without knowledge of the final state of the transition. The possible transition states are studied as a function of interstitial cluster size, and the lowest energy barriers correspond to defect migration along (111) directions, as seen in MD simulations. Small clusters change their direction by a (110) fragment mechanism involving rotation of each crowdion into and out of the (110) dumbbell configuration, whereas the directional change for larger clusters is a two-step process consisting of translation along a <100> direction and rotation into an equivalent (111) direction. The mechanism of changing direction for a tri-interstitial cluster is also investigated using MD simulations.

  6. Study of thermal-gradient-induced migration of brine inclusions in salt. Final report

    SciTech Connect (OSTI)

    Olander, D.R.

    1984-08-01T23:59:59.000Z

    Natural salt deposits, which are being considered for high-level waste disposal, contain a small volume fraction of water in the form of brine inclusions distributed throughout the salt. Radioactive decay heating of the nuclear wastes will impose a temperature gradient on the surrounding salt which mobilizes the brine inclusions. Inclusions filled completely with brine (the all-liquid inclusions) migrate up the temperature gradient and eventually accumulate brine near the buried waste forms. The brine may slowly corrode or degrade the waste forms, which is undesirable. Therefore it is important to consider the migration of brine inclusions in salt under imposed temperature gradients to properly evaluate the performance of a future salt repository for nuclear wastes. The migration velocities of the inclusions were found to be dependent on temperature, temperature gradient, and inclusion shape and size. The velocities were also dictated by the interfacial mass transfer resistance at brine/solid interface. This interfacial resistance depends on the dislocation density in the crystal, which in turn, depends on the axial compressive loading of the crystal. At low axial loads, the dependence between the velocity and temperature gradient is nonlinear. At high axial loads, the interfacial resistance is reduced and the migration velocity depends linearly on the temperature gradient. All-liquid inclusions filled with mixed brines were also studied. For gas-liquid inclusions, helium, air and argon were compared. Migration studies were also conducted on single crystallites of natural salt as well as in polycrystalline natural salt samples. The behavior of the inclusions at large-ange grain boundaries was observed.

  7. Heterologous protein production using the twin arginine translocation pathway

    DOE Patents [OSTI]

    Pohlschroder, Mechtild (Philadelphia, PA); Kissinger, Jessica C (Athens, GA); Rose, R. Wesley (Glenside, PA); Brueser, Thomas (Halle, DE); Dilks, Kieran (Collingswood, NJ)

    2008-11-04T23:59:59.000Z

    Provided are means for evaluating and identifying putative substrates of the twin arginine translocation (Tat) secretory pathway in Streptomyces and other bacterial species. Also provided, therefore, are simple ways to express, secrete and purify correctly folded heterologous proteins on a large scale using host microorganisms, such as, Streptomyces and the Tat pathway therein. Many of the thus-produced proteins are of significant therapeutic value in the pharmaceutical and biochemical industries, particularly when they can be secreted from the host in fully-folded active form. Accordingly, there are further provided the heterologous proteins produced by the Tat secretion pathway using the foregoing methods, and the computer algorithm used to identify the Tat signal sequence and putative substrates.

  8. Visualizing kinetic pathways of homogeneous nucleation in colloidal crystallization

    E-Print Network [OSTI]

    Peng Tan; Ning Xu; Lei Xu

    2014-12-18T23:59:59.000Z

    When a system undergoes a transition from a liquid to a solid phase, it passes through multiple intermediate structures before reaching the final state. However, our knowledge on the exact pathways of this process is limited, mainly due to the difficulty of realizing direct observations. Here, we experimentally study the evolution of symmetry and density for various colloidal systems during liquid-to-solid phase transitions, and visualize kinetic pathways with single-particle resolution. We observe the formation of relatively-ordered precursor structures with different symmetries, which then convert into metastable solids. During this conversion, two major cross-symmetry pathways always occur, regardless of the final state and the interaction potential. In addition, we find a broad decoupling of density variation and symmetry development, and discover that nucleation rarely starts from the densest regions. These findings hold for all our samples, suggesting the possibility of finding a unified picture for the complex crystallization kinetics in colloidal systems.

  9. Low energy pathways for reproducible in vivo protein folding

    E-Print Network [OSTI]

    Leonor Cruzeiro

    2011-01-03T23:59:59.000Z

    Two proteins, one belonging to the mainly alpha class and the other belonging to the alpha/beta class, are selected to test a kinetic mechanism for protein folding. Targeted molecular dynamics is applied to generate folding pathways for those two proteins, starting from two well defined initial conformations: a fully extended and a alpha-helical conformation. The results show that for both proteins the alpha-helical initial conformation provides overall lower energy pathways to the native state. For the alpha/beta protein, 30 % (40%) of the pathways from an initial alpha-helix (fully extended) structure lead to unentangled native folds, a success rate that can be increased to 85 % by the introduction of a well-defined intermediate structure. These results open up a new direction in which to look for a solution to the protein folding problem, as detailed at the end.

  10. Tracking a defined route for O2 migration in a dioxygen-activating diiron enzyme

    E-Print Network [OSTI]

    Song, Woon Ju

    For numerous enzymes reactive toward small gaseous compounds, growing evidence indicates that these substrates diffuse into active site pockets through defined pathways in the protein matrix. Toluene/o-xylene monooxygenase ...

  11. Clean-up standards and pathways analysis methods

    SciTech Connect (OSTI)

    Devgun, J.S. [Argonne National Lab., IL (United States). Office of Waste Management Programs

    1993-12-31T23:59:59.000Z

    Remediation of a radioactively contaminated site requires that certain regulatory criteria be met before the site can be released for unrestricted future use. Since the ultimate objective of remediation is to protect the public health and safety, residual radioactivity levels remaining at a site after cleanup must be below certain preset limits or meet acceptable dose or risk criteria. This paper discusses cleanup standards for radioactively contaminated soils and describes the use of pathways analysis methods for deriving site-specific residual radioactivity guidelines. An example is provided in which a pathways analysis code (RESRAD) was used to establish such guidelines.

  12. Controlled entanglement routing between two virtual pathways

    E-Print Network [OSTI]

    Qiang Zhou; Shuai Dong; Wei Zhang; Lixing You; Yuhao He; Weijun Zhang; Yidong Huang; Jiangde Peng

    2014-07-16T23:59:59.000Z

    We demonstrate controlled entanglement routing between bunching and antibunching path-entangled two-photon states in an unbalanced Mach-Zehnder interferometer (UMZI), in which the routing process is controlled by the relative phase difference in the UMZI. Regarding bunching and antibunching path-entangled two-photon states as two virtual ports, we can consider the UMZI as a controlled entanglement router, which bases on the coherent manipulation of entanglement. Half of the entanglement within the input two-photon state is coherently routed between the two virtual ports, while the other is lost due to the time distinguishability introduced by the UMZI. Pure bunching or antibunching path entangled two-photon states are obtained based on this controlled entanglement router. The results show that we can employ the UMZI as general entanglement router for practical quantum information application.

  13. Developmental time windows for axon growth influence neuronal network topology

    E-Print Network [OSTI]

    Lim, Sol

    2015-01-01T23:59:59.000Z

    Early brain connectivity development consists of multiple stages: birth of neurons, their migration and the subsequent growth of axons and dendrites. Each stage occurs within a certain period of time depending on types of neurons and cortical layers. Forming synapses between neurons either by growing axons starting at similar times for all neurons (much-overlapped time windows) or at different time points (less-overlapped) may affect the topological and spatial properties of neuronal networks. Here, we explore the extreme cases of axon formation especially concerning short-distance connectivity during early development, either starting at the same time for all neurons (parallel, i.e. maximally-overlapped time windows) or occurring for each neuron separately one neuron after another (serial, i.e. no overlaps in time windows). For both cases, the number of potential and established synapses remained comparable. Topological and spatial properties, however, differed: neurons that started axon growth early on in s...

  14. Oxygen migration in TiO{sub 2}-based higher-k gate stacks

    SciTech Connect (OSTI)

    Kim, Sang Bum; Brown, Stephen L.; Rossnagel, Stephen M.; Bruley, John; Copel, Matthew; Hopstaken, Marco J. P.; Narayanan, Vijay; Frank, Martin M. [IBM T.J. Watson Research Center, 1101 Kitchawan Road, Yorktown Heights, New York 10598 (United States)

    2010-03-15T23:59:59.000Z

    We report on the stability of high-permittivity (high-k) TiO{sub 2} films incorporated in metal-oxide-silicon capacitor structures with a TiN metal gate electrode, focusing on oxygen migration. Titanium oxide films are deposited by either Ti sputtering [physical vapor deposition (PVD)] followed by radical shower oxidation or by plasma-enhanced atomic layer deposition (PEALD) from titanium isopropoxide (Ti{l_brace}OCH(CH{sub 3}){sub 2{r_brace}4}) and O{sub 2} plasma. Both PVD and PEALD films result in near-stoichiometric TiO{sub 2} prior to high-temperature annealing. We find that dopant activation anneals of TiO{sub 2}-containing gate stacks at 1000 deg. C cause 5 A or more of additional SiO{sub 2} to be formed at the gate-dielectric/Si-channel interface. Furthermore, we demonstrate for the first time that oxygen released from TiO{sub 2} diffuses through the TiN gate electrode and oxidizes the poly-Si contact. The thickness of this upper SiO{sub 2} layer continues to increase with increasing TiO{sub 2} thickness, while the thickness of the regrown SiO{sub 2} at the gate-dielectric/Si interface saturates. The upper SiO{sub 2} layer degrades gate stack capacitance, and simultaneously the oxygen-deficient TiO{sub x} becomes a poor insulator. In an attempt to mitigate O loss from the TiO{sub 2}, top and bottom Al{sub 2}O{sub 3} layers are added to the TiO{sub 2} gate dielectric as oxygen barriers. However, they are found to be ineffective, due to Al{sub 2}O{sub 3}-TiO{sub 2} interdiffusion during activation annealing. Bottom HfO{sub 2}/Si{sub 3}N{sub 4} interlayers are found to serve as more effective oxygen barriers, reducing, though not preventing, oxygen downdiffusion.

  15. Time Off

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del SolStrengthening a solidSynthesis ofwas publishedThree scientistsDepartmentTime Off

  16. Icariin stimulates angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells

    SciTech Connect (OSTI)

    Chung, Byung-Hee [Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon-do 200-701 (Korea, Republic of); Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chunchon, Kangwon-do (Korea, Republic of); Kim, Jong-Dai [Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chunchon, Kangwon-do (Korea, Republic of); Kim, Chun-Ki; Kim, Jung Huan [Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon-do 200-701 (Korea, Republic of); Won, Moo-Ho [Department of Anatomy, School of Medicine, Hallym University, Chunchon, Kangwon-do (Korea, Republic of); Lee, Han-Soo [Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon-do 200-701 (Korea, Republic of); Dong, Mi-Sook [School of Life Sciences and Biotechnology, Korea University, 1, 5-Ka, Anam-dong, Sungbuk-ku, Seoul 136-701 (Korea, Republic of); Ha, Kwon-Soo [Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon-do 200-701 (Korea, Republic of); Kwon, Young-Geun [Department of Biochemistry, College of Sciences, Yonsei University, Seoul (Korea, Republic of); Kim, Young-Myeong [Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon-do 200-701 (Korea, Republic of)], E-mail: ymkim@kangwon.ac.kr

    2008-11-14T23:59:59.000Z

    We investigated the molecular effect and signal pathway of icariin, a major flavonoid of Epimedium koreanum Nakai, on angiogenesis. Icariin stimulated in vitro endothelial cell proliferation, migration, and tubulogenesis, which are typical phenomena of angiogenesis, as well as increased in vivo angiogenesis. Icariin activated the angiogenic signal modulators, ERK, phosphatidylinositol 3-kinase (PI3K), Akt, and endothelial nitric oxide synthase (eNOS), and increased NO production, without affecting VEGF expression, indicating that icariin may directly stimulate angiogenesis. Icariin-induced ERK activation and angiogenic events were significantly inhibited by the MEK inhibitor PD98059, without affecting Akt and eNOS phosphorylation. The PI3K inhibitor Wortmannin suppressed icariin-mediated angiogenesis and Akt and eNOS activation without affecting ERK phosphorylation. Moreover, the NOS inhibitor NMA partially reduced the angiogenic activity of icariin. These results suggest that icariin stimulated angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways and may be a useful drug for angiogenic therapy.

  17. Nuclear Naval Propulsion: A Feasible Proliferation Pathway?

    SciTech Connect (OSTI)

    Swift, Alicia L.

    2014-01-31T23:59:59.000Z

    There is no better time than now to close the loophole in Article IV of the Nuclear Non-proliferation Treaty (NPT) that excludes military uses of fissile material from nuclear safeguards. Several countries have declared their intention to pursue and develop naval reactor technology, including Argentina, Brazil, Iran, and Pakistan, while other countries such as China, India, Russia, and the United States are expanding their capabilities. With only a minority of countries using low enriched uranium (LEU) fuel in their naval reactors, it is possible that a state could produce highly enriched uranium (HEU) under the guise of a nuclear navy while actually stockpiling the material for a nuclear weapon program. This paper examines the likelihood that non-nuclear weapon states exploit the loophole to break out from the NPT and also the regional ramifications of deterrence and regional stability of expanding naval forces. Possible solutions to close the loophole are discussed, including expanding the scope of the Fissile Material Cut-off Treaty, employing LEU fuel instead of HEU fuel in naval reactors, amending the NPT, creating an export control regime for naval nuclear reactors, and forming individual naval reactor safeguards agreements.

  18. Coupled electron-nuclear dynamics: Charge migration and charge transfer initiated near a conical intersection

    SciTech Connect (OSTI)

    Mendive-Tapia, David; Vacher, Morgane; Bearpark, Michael J.; Robb, Michael A. [Department of Chemistry, Imperial College London, London SW7 2AZ (United Kingdom)] [Department of Chemistry, Imperial College London, London SW7 2AZ (United Kingdom)

    2013-07-28T23:59:59.000Z

    Coupled electron-nuclear dynamics, implemented using the Ehrenfest method, has been used to study charge migration with fixed nuclei, together with charge transfer when nuclei are allowed to move. Simulations were initiated at reference geometries of neutral benzene and 2-phenylethylamine (PEA), and at geometries close to potential energy surface crossings in the cations. Cationic eigenstates, and the so-called sudden approximation, involving removal of an electron from a correlated ground-state wavefunction for the neutral species, were used as initial conditions. Charge migration without coupled nuclear motion could be observed if the Ehrenfest simulation, using the sudden approximation, was started near a conical intersection where the states were both strongly coupled and quasi-degenerate. Further, the main features associated with charge migration were still recognizable when the nuclear motion was allowed to couple. In the benzene radical cation, starting from the reference neutral geometry with the sudden approximation, one could observe sub-femtosecond charge migration with a small amplitude, which results from weak interaction with higher electronic states. However, we were able to engineer large amplitude charge migration, with a period between 10 and 100 fs, corresponding to oscillation of the electronic structure between the quinoid and anti-quinoid cationic electronic configurations, by distorting the geometry along the derivative coupling vector from the D{sub 6h} Jahn-Teller crossing to lower symmetry where the states are not degenerate. When the nuclear motion becomes coupled, the period changes only slightly. In PEA, in an Ehrenfest trajectory starting from the D{sub 2} eigenstate and reference geometry, a partial charge transfer occurs after about 12 fs near the first crossing between D{sub 1}, D{sub 2} (N{sup +}-Phenyl, N-Phenyl{sup +}). If the Ehrenfest propagation is started near this point, using the sudden approximation without coupled nuclear motion, one observes an oscillation of the spin density – charge migration – between the N atom and the phenyl ring with a period of 4 fs. When the nuclear motion becomes coupled, this oscillation persists in a damped form, followed by an effective charge transfer after 30 fs.

  19. A Protein Export Pathway Involving Escherichia coli Porins

    E-Print Network [OSTI]

    McIntosh, Lawrence P.

    Structure Article A Protein Export Pathway Involving Escherichia coli Porins Gerd Prehna,1,2 Guijin@byron.biochem.ubc.ca (N.C.J.S.) DOI 10.1016/j.str.2012.04.014 SUMMARY Escherichia coli export the protein Yeb common to all E. coli strains has been reported, the mechanism of export has remained unclear. Herein, we

  20. Comparing classical pathways and modern networks: towards the

    E-Print Network [OSTI]

    Gerstein, Mark

    the isolation of one pathway from another. Conversely, modern high-throughput (HTP) experiments offer. As more diverse types of HTP data become avail- able, both perspectives can be effectively merged between many proteins. Conver- sely, modern high-throughput (HTP) experiments and large-scale databases

  1. Biogas Production through the Syntrophic Acetate-Oxidising Pathway

    E-Print Network [OSTI]

    Biogas Production through the Syntrophic Acetate-Oxidising Pathway Characterisation and Detection Uppsala 2012 #12;Acta Universitatis agriculturae Sueciae 2012:45 #12;Biogas production through 1.1 Aims of the thesis 12 2 Biogas production 15 2.1 Biogas production in Europe 16 2.2 Substrate

  2. Hydrochemical and isotopic effects associated with petroleum fuel biodegradation pathways

    E-Print Network [OSTI]

    Sheffield, University of

    hydrocarbons and residual electron acceptors have been used to deduce BTEX and MTBE degradation pathways. Benzene and MTBE persist into the denitrification zone, with carbon isotope enrichment of benzene-enrichment of residual benzene gives an apparent e value of Ã?0.66x. MTBE shows no significant isotopic enrichment (d13 C

  3. Signal Transduction Pathways that Regulate CAB Gene Expression

    SciTech Connect (OSTI)

    Chory, Joanne

    2006-01-16T23:59:59.000Z

    The process of chloroplast differentiation, involves the coordinate regulation of many nuclear and chloroplast genes. The cues for the initiation of this developmental program are both extrinsic (e.g., light) and intrinsic (cell-type and plastid signals). During this project period, we utilized a molecular genetic approach to select for Arabidopsis mutants that did not respond properly to environmental light conditions, as well as mutants that were unable to perceive plastid damage. These latter mutants, called gun mutants, define two retrograde signaling pathways that regulate nuclear gene expression in response to chloroplasts. A major finding was to identify a signal from chloroplasts that regulates nuclear gene transcription. This signal is the build-up of Mg-Protoporphyrin IX, a key intermediate of the chlorophyll biosynthetic pathway. The signaling pathways downstream of this signal are currently being studied. Completion of this project has provided an increased understanding of the input signals and retrograde signaling pathways that control nuclear gene expression in response to the functional state of chloroplasts. These studies should ultimately influence our abilities to manipulate plant growth and development, and will aid in the understanding of the developmental control of photosynthesis.

  4. Signal Transduction Pathways that Regulate CAB Gene Expression

    SciTech Connect (OSTI)

    Chory, Joanne

    2004-12-31T23:59:59.000Z

    The process of chloroplast differentiation, involves the coordinate regulation of many nuclear and chloroplast genes. The cues for the initiation of this developmental program are both extrinsic (e.g., light) and intrinsic (cell-type and plastid signals). During this project period, we utilized a molecular genetic approach to select for Arabidopsis mutants that did not respond properly to environmental light conditions, as well as mutants that were unable to perceive plastid damage. These latter mutants, called gun mutants, define two retrograde signaling pathways that regulate nuclear gene expression in response to chloroplasts. A major finding was to identify a signal from chloroplasts that regulates nuclear gene transcription. This signal is the build-up of Mg-Protoporphyrin IX, a key intermediate of the chlorophyll biosynthetic pathway. The signaling pathways downstream of this signal are currently being studied. Completion of this project has provided an increased understanding of the input signals and retrograde signaling pathways that control nuclear gene expression in response to the functional state of chloroplasts. These studies should ultimately influence our abilities to manipulate plant growth and development, and will aid in the understanding of the developmental control of photosynthesis.

  5. A Pathway in Primate Brain for Internal Monitoring of

    E-Print Network [OSTI]

    Crawford, Doug

    - press MD relay neurons without affecting transthalamic fibers passing nearby. We test- ed monkeys circuits in the midbrain and pons (19), and some go upstream to mediodorsal thalamus (MD) relay neurons- ing pathway carries corollary discharges of saccadic commands. To test this hypothesis, first we

  6. Alternative pathways to fusion energy (focus on Department of Energy

    E-Print Network [OSTI]

    Alternative pathways to fusion energy (focus on Department of Energy Innovative Confinement for a restructured fusion energy science program [5] 1996 | FESAC: Opportunities in Alternative Confinement Concepts, suggests program for Innovative Concepts [1] 1995 | OTA TPX and the Alternates [2] 1995 | PCAST (given flat

  7. Questioning Inevitability of Energy Pathways: Alternative Energy Scenarios for California

    E-Print Network [OSTI]

    Kammen, Daniel M.

    Questioning Inevitability of Energy Pathways: Alternative Energy Scenarios for California May 21.6.4 Alternative Scenario 3 ­ Patriotic Energy Independence Section 3: Developing the Scenario Model and Examining, 2002 by Rebecca Ghanadan rebeccag@socrates.berkeley.edu The Energy and Resources Group University

  8. Roaming radical pathways for the decomposition of alkanes.

    SciTech Connect (OSTI)

    Harding, L. B.; Klippenstein, S. J. (Chemical Sciences and Engineering Division)

    2010-01-01T23:59:59.000Z

    CASPT2 calculations predict the existence of roaming radical pathways for the decomposition of propane, n-butane, isobutane and neopentane. The roaming radical paths lead to the formation of an alkane and an alkene instead of the expected radical products. The predicted barriers for the roaming radical paths lie {approx}1 kcal/mol below the corresponding radical asymptotes.

  9. 2002 Fusion Summer Study Development Pathway Subgroup (E 4)

    E-Print Network [OSTI]

    2002 Fusion Summer Study Development Pathway Subgroup (E 4) Final Report July 25, 2002 #12;6. Development Path Scenarios The development path to realize fusion as a practical energy source must include performance, steady-state operation; 4) Development of low-activation materials and fusion technologies

  10. 2002 Fusion Summer Study Subgroup E4 -Development Pathway Subgroup

    E-Print Network [OSTI]

    Najmabadi, Farrokh

    2002 Fusion Summer Study Subgroup E4 - Development Pathway Subgroup Draft by: Farrokh Najmabadi A burning plasma experiment is a key step in developing fusion. The realization of fusion, however, requires and fusion power technologies, etc. An important discriminator among various embodiments of burning plasma

  11. Metabolism and proliferation share common regulatory pathways in cancer

    E-Print Network [OSTI]

    Boyer, Edmond

    Metabolism and proliferation share common regulatory pathways in cancer cells. Vanessa Fritz, proliferation, and cancer inserm-00491405,version1-11Jun2010 Author manuscript, published in "Oncogene 2010;29(31):4369-77" DOI : 10.1038/onc.2010.182 #12;Metabolism, proliferation and cancer Fritz and Fajas 2 Abstract Cancer

  12. Prioritizing Acquisition Pathways in the State Level Concept

    SciTech Connect (OSTI)

    Murphy, Chantell L. [Los Alamos National Laboratory; Budlong-Sylvester, Kory [Los Alamos National Laboratory; Pilat, Joseph F. [Los Alamos National Laboratory

    2012-06-27T23:59:59.000Z

    The International Atomic Energy Agency's (IAEA) Department of Safeguards has launched a project to further develop the State-level concept for the planning, implementation, and evaluation of safeguards activities. In order to further evolve the safeguards system an emphasis is placed on integrating inspection-related activities and the State evaluation process to draw safeguards conclusions in the most efficient way. The credible implementation of acquisition pathway analysis is central to the success of the IAEA's State-level concept. NNSA's Office of Nuclear Safeguards and Security (NA-241) The Next Generation Safeguards Initiative (NGSI) is sponsoring Los Alamos National Laboratory (LANL) to produce a study that will examine the use of acquisition pathway analysis in: (1) Developing a State-specific, State-level approach (SLA) and Annual Implementation Plan (AIP); (2) Maximizing the utility of the physical model; and (3) Supporting resource allocation decisions through a pathway prioritization. To deal with the challenge of developing an effective and efficient SLA, this study looks at: (1) Prioritizing proliferation pathways based on an assessment of a State's capabilities and assumed proliferation strategies; and (2) Relevant State behavior (e.g., transparency, cooperation, etc.) while avoiding subjective judgments about States themselves. The study makes use of case studies and concrete examples in order to illustrate how new concepts and approaches will be implemented, and how they may differ from more traditional safeguards approaches.

  13. A Single Disulfide Bond Differentiates Aggregation Pathways of 2-Microglobulin

    E-Print Network [OSTI]

    Dokholyan, Nikolay V.

    simulation; aggregation; domain swapping*Corresponding author Introduction Amyloid fibrils are insolubleA Single Disulfide Bond Differentiates Aggregation Pathways of ß2-Microglobulin Yiwen Chen1 at Chapel Hill Chapel Hill, NC 27599, USA Deposition of wild-type ß2-microglobulin (ß2m) into amyloid

  14. Hierarchical Protein Folding Pathways: A Computational Study of Protein Fragments

    E-Print Network [OSTI]

    Haspel, Nurit

    Hierarchical Protein Folding Pathways: A Computational Study of Protein Fragments Nurit Haspel,1 folding model. The model postulates that protein folding is a hierarchical top-down pro- cess. The basic words: protein folding; building blocks; pro- tein structure prediction; hierarchical folding; protein

  15. Correct and incorrect nucleotide incorporation pathways in DNA polymerase b

    E-Print Network [OSTI]

    Schlick, Tamar

    Correct and incorrect nucleotide incorporation pathways in DNA polymerase b Ravi Radhakrishnan a nucleotide incorporations in the DNA by using a novel protocol involving energy minimizations, dynamics simu- sive transient intermediates, for nucleotide incorporation at the template/primer DNA junction. A large

  16. Supplementary Information Programming Biomolecular Self-Assembly Pathways

    E-Print Network [OSTI]

    Pierce, Niles A.

    Supplementary Information Programming Biomolecular Self-Assembly Pathways Peng Yin1,2 , Harry M.T. Choi1 , Colby R. Calvert1 & Niles A. Pierce1,3, 1Department of Bioengineering, 2Department of Computer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 S6.7 Statistical analysis

  17. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    example, the electricity system depends on other infrastructures that deliver coal or natural gas and less on the natural gas or electricity infrastructure supplying energy to make hydrogen). TodaySUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan

  18. TECHNICAL REPORTS Understanding nutrient pathways to streams will improve

    E-Print Network [OSTI]

    , in most watersheds terrestrial P exports are greatest where surface waters transport P-rich soils rapTECHNICAL REPORTS 1892 Understanding nutrient pathways to streams will improve nutrient management) concentrations in several environmental compartments were examined in watersheds having a range of base flow

  19. Fate and transport processes controlling the migration of hazardous and radioactive materials from the Area 5 Radioactive Waste Management Site (RWMS)

    SciTech Connect (OSTI)

    Estrella, R.

    1994-10-01T23:59:59.000Z

    Desert vadose zones have been considered as suitable environments for the safe and long-term isolation of hazardous wastes. Low precipitation, high evapotranspiration and thick unsaturated alluvial deposits commonly found in deserts make them attractive as waste disposal sites. The fate and transport of any contaminant in the subsurface is ultimately determined by the operating retention and transformation processes in the system and the end result of the interactions among them. Retention (sorption) and transformation are the two major processes that affect the amount of a contaminant present and available for transport. Retention processes do not affect the total amount of a contaminant in the soil system, but rather decrease or eliminate the amount available for transport at a given point in time. Sorption reactions retard the contaminant migration. Permanent binding of solute by the sorbent is also possible. These processes and their interactions are controlled by the nature of the hazardous waste, the properties of the porous media and the geochemical and environmental conditions (temperature, moisture and vegetation). The present study summarizes the available data and investigates the fate and transport processes that govern the migration of contaminants from the Radioactive Waste Management Site (RWMS) in Area 5 of the Nevada Test Site (NTS). While the site is currently used only for low-level radioactive waste disposal, past practices have included burial of material now considered hazardous. Fundamentals of chemical and biological transformation processes are discussed subsequently, followed by a discussion of relevant results.

  20. Ell3 stimulates proliferation, drug resistance, and cancer stem cell properties of breast cancer cells via a MEK/ERK-dependent signaling pathway

    SciTech Connect (OSTI)

    Ahn, Hee-Jin [Department of Biomedical Science, College of Life Science, CHA University, Seoul (Korea, Republic of)] [Department of Biomedical Science, College of Life Science, CHA University, Seoul (Korea, Republic of); Kim, Gwangil [Department of Pathology, CHA Bundang Medical Center, CHA University, Seoul (Korea, Republic of)] [Department of Pathology, CHA Bundang Medical Center, CHA University, Seoul (Korea, Republic of); Park, Kyung-Soon, E-mail: kspark@cha.ac.kr [Department of Biomedical Science, College of Life Science, CHA University, Seoul (Korea, Republic of)] [Department of Biomedical Science, College of Life Science, CHA University, Seoul (Korea, Republic of)

    2013-08-09T23:59:59.000Z

    Highlights: •Ell3 enhances proliferation and drug resistance of breast cancer cell lines. •Ell3 is related to the cancer stem cell characteristics of breast cancer cell lines. •Ell3 enhances oncogenicity of breast cancer through the ERK1/2 signaling pathway. -- Abstract: Ell3 is a RNA polymerase II transcription elongation factor that is enriched in testis. The C-terminal domain of Ell3 shows strong similarities to that of Ell (eleven?nineteen lysine-rich leukemia gene), which acts as a negative regulator of p53 and regulates cell proliferation and survival. Recent studies in our laboratory showed that Ell3 induces the differentiation of mouse embryonic stem cells by protecting differentiating cells from apoptosis via the promotion of p53 degradation. In this study, we evaluated the function of Ell3 in breast cancer cell lines. MCF-7 cell lines overexpressing Ell3 were used to examine cell proliferation and cancer stem cell properties. Ectopic expression of Ell3 in breast cancer cell lines induces proliferation and 5-FU resistance. In addition, Ell3 expression increases the cancer stem cell population, which is characterized by CD44 (+) or ALDH1 (+) cells. Mammosphere-forming potential and migration ability were also increased upon Ell3 expression in breast cancer cell lines. Through biochemical and molecular biological analyses, we showed that Ell3 regulates proliferation, cancer stem cell properties and drug resistance in breast cancer cell lines partly through the MEK?extracellular signal-regulated kinase signaling pathway. Murine xenograft experiments showed that Ell3 expression promotes tumorigenesis in vivo. These results suggest that Ell3 may play a critical role in promoting oncogenesis in breast cancer by regulating cell proliferation and cancer stem cell properties via the ERK1/2 signaling pathway.

  1. First principles investigation of Ti adsorption and migration on Si(100) surfaces

    SciTech Connect (OSTI)

    Briquet, Ludovic G. V.; Wirtz, Tom; Philipp, Patrick, E-mail: philipp@lippmann.lu [Department of Science and Analysis of Materials (SAM), Centre de Recherche Public - Gabriel Lippmann, 41 rue du Brill, L-4422 Belvaux (Luxembourg)

    2013-12-28T23:59:59.000Z

    The titanium adsorption on Si(100) is investigated using first principles computer modelling methods. Two new subsurface adsorption sites are described. They are located at the edge of the cavity topped by a surface silicon dimer. The migration of the titanium from the surface to the subsurface sites is facilitated when occurring via one of these sites. The ejection of one of the silicon atoms forming the surface dimer is also investigated. The actual step of the ejection requires more energy than previously thought although, when considering the global picture of a titanium atom on the surface leading to the ejection of a silicon atom, the overall rate is compensated by the facilitated migration of the titanium to the subsurface sites. The consecutive adsorption of a second and third titanium atom is also investigated. It is shown that titanium grows evenly on the surface in normal condition, showing no intermixing of the titanium and silicon beyond the silicon layer.

  2. OUTER-DISK POPULATIONS IN NGC 7793: EVIDENCE FOR STELLAR RADIAL MIGRATION

    SciTech Connect (OSTI)

    Radburn-Smith, David J.; Dalcanton, Julianne J. [Department of Astronomy, University of Washington, Seattle, WA 98195 (United States); Roskar, Rok [Institut fuer Theoretische Physik, Universitaet Zuerich (Switzerland); Debattista, Victor P. [Jeremiah Horrocks Institute, University of Central Lancashire, Preston PR1 2HE (United Kingdom); Streich, David; De Jong, Roelof S.; Vlajic, Marija [Leibniz-Institut fuer Astrophysik Potsdam, D-14482 Potsdam (Germany); Holwerda, Benne W. [European Space Agency, ESTEC, 2200 AG Noordwijk (Netherlands); Purcell, Chris W. [Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, PA 15260 (United States); Dolphin, Andrew E. [Raytheon, 1151 E. Hermans Road, Tucson, AZ 85756 (United States); Zucker, Daniel B. [Department of Physics and Astronomy, Macquarie University, NSW 2109 (Australia)

    2012-07-10T23:59:59.000Z

    We analyzed the radial surface brightness profile of the spiral galaxy NGC 7793 using HST/ACS images from the GHOSTS survey and a new HST/WFC3 image across the disk break. We used the photometry of resolved stars to select distinct populations covering a wide range of stellar ages. We found breaks in the radial profiles of all stellar populations at 280'' ({approx}5.1 kpc). Beyond this disk break, the profiles become steeper for younger populations. This same trend is seen in numerical simulations where the outer disk is formed almost entirely by radial migration. We also found that the older stars of NGC 7793 extend significantly farther than the underlying H I disk. They are thus unlikely to have formed entirely at their current radii, unless the gas disk was substantially larger in the past. These observations thus provide evidence for substantial stellar radial migration in late-type disks.

  3. Calculation of the pentose phosphate and Embden-Myerhoff pathways from a single incubation with (U-/sup 14/C)- and (5-/sup 3/H)glucose

    SciTech Connect (OSTI)

    O'Fallon, J.V.; Wright, R.W. Jr.

    1987-04-01T23:59:59.000Z

    A method that simultaneously determines Embden-Myerhoff pathway and pentose phosphate pathway (PPP) activities from an incubation with (U-/sup 14/C)- and (5-/sup 3/H)glucose is presented. The method relies on the use of unlabeled pyruvate and lactate to dilute out radiolabel entering the tricarboxylic acid cycle. Gluconeogenesis from pyruvate is prevented by the use of an incubation chamber that maintains a CO/sub 2/ (and bicarbonate) free environment. The method, which includes the contribution by the recycling steps of the PPP, is especially useful when biological material is limited or developmental timing is critical.

  4. Sphingosine-1-phosphate inhibits vascular smooth muscle cell migration by activating G??? and RhoA

    E-Print Network [OSTI]

    Anthis, Nicholas J

    2013-02-22T23:59:59.000Z

    SPHINGOSINE-I-PHOSPHATE INHIBITS VASCULAR SMOOTH MUSCLE CELL MIGRATION BY ACTIVATING G~tt AND RhoA A Senior Honors Thesis by NICHOLAS J. ANTHIS Submitted to the Office of Honors Programs & Academic Scholarships Texas A&M University... by NICHOLAS J. ANTHIS Submitted to the Office of Honors Programs & Academic Scholarships Texas ARM University In partial fulfillment of the designation of UNIVERSITY UNDERGRADUATE RESEARCH FELLOW Approved as to style and content by: +g...

  5. The Kazakhs of Western Mongolia: Transnational Migration from 1990-2008 

    E-Print Network [OSTI]

    Barcus, Holly; Werner, Cynthia

    2010-01-01T23:59:59.000Z

    dawned, Mongolia and Bayan-Ulgii began a slow emergence. Bayan-Ulgii has the unique distinction in Mongolia as the only province sharing two international borders, one with Russia and one with China. These borders, as they became more open, created... and are affected by national, local, and individual circumstances. Keywords: Kazakhs; migration; diaspora; repatriation; Mongolia; Kazakhstan Introduction and background Through the creation of national borders, individuals identifying strongly with one ethnic...

  6. On the role of Allee effect and mass migration in survival and extinction of a species

    E-Print Network [OSTI]

    Borrello, Davide

    2010-01-01T23:59:59.000Z

    We investigate survival and extinction of a species in metapopulation dynamics models with particular biological phenomena. We prove that the presence of Allee effect may be critical for survival and that the migration of large flocks of individuals is a possible solution to avoid extinction when the Allee effect is strong. We prove the existence of critical parameters for each model and in supercritical case we construct (at least) one non-trivial invariant measure.

  7. An investigation of pneumatic control on immiscible contaminant migration in confined aquifers

    E-Print Network [OSTI]

    Watts, John David

    1991-01-01T23:59:59.000Z

    ? dimensional (vertical and lateral) finite ? element contaminant groundwater simulator to investigate the migration of NAPL's in the unsaturated zone. The physical conception of this model is based upon the salt/fresh water interface problem occurring..., or the use of water-flooding in secondary recovery operations. " Faust[1985] and Faust et uk[1989] attested to the validity of known and accepted petroleum engineering mathematical models used to describe multiphase flow through porous media. Osborne...

  8. IMMIGRATION, MIGRATION ET LIBRE CIRCULATION DANS LA CONSTRUCTION DE L'EUROPE

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    IMMIGRATION, MIGRATION ET LIBRE CIRCULATION DANS LA CONSTRUCTION DE L'EUROPE Adrian Favell L'Harmattan-64. -------------------------------------------------------------------------------------------------------------------- Distribution électronique Cairn.info pour L'Harmattan. © L'Harmattan. Tous droits réservés pour tous pays. La.cairn.info-Institutd'EtudesPolitiquesdeParis--193.54.67.94-15/07/201416h15.©L'Harmattan Documenttéléchargédepuiswww

  9. Rflexions autour des migrations forces en Afrique sub-saharienne1

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    réfugiés climatiques. Enfin, il insiste, à travers des études de cas, sur les territoires générés par ces, 2009). Ainsi, ce rapport remet en cause l'idée reçue concernant l'ampleur des migrations sud-nord alors recherche académique et des pouvoirs politiques au Nord. Ils accaparent l'attention et font l'objet d

  10. Electronic Materials Conference (EMC), 6-25-2009 Improved Migration-Enhanced

    E-Print Network [OSTI]

    Rodwell, Mark J. W.

    Electronic Materials Conference (EMC), 6-25-2009 Improved Migration-Enhanced Epitaxy for Self ·Scalable III-V MOSFETs ·The Shape of Things to Come·The Shape of Things to Come 2Wistey, EMC 2009 #12 · Heteroepitaxy 3Wistey, EMC 2009 W.K. Liu et al., J. Crystal Growth v. 311, p. 1979 (2009)· Selective area growth

  11. Global m=1 modes and migration of protoplanetary cores in eccentric protoplanetary discs

    E-Print Network [OSTI]

    J. C. B. Papaloizou

    2002-04-11T23:59:59.000Z

    We calculate global $m=1$ modes with low pattern speed corresponding to introducing a finite eccentricity into a protoplanetary disc. We consider disc models which are either isolated or contain one or two protoplanets orbiting in an inner cavity. Global modes that are strongly coupled to inner protoplanets are found to have disc orbits which tend to have apsidal lines antialigned with respect to those of the inner protoplanets. Other modes corresponding to free disc modes may be global over a large range of length scales and accordingly be long lived. We consider the motion of a protoplanet in the earth mass range embedded in an eccentric disc and determine the equilibrium orbits which maintain fixed apsidal alignment with respect to the disc gas orbits. Equilibrium eccentricities are found to be comparable or possibly exceed the disc eccentricity. We then approximately calculate the tidal interaction with the disc in order to estimate the orbital migration rate. Results are found to deviate from the case of axisymmetric disc with near circular protoplanet orbit once eccentricities of protoplanet and disc orbits become comparable to the disc aspect ratio in magnitude. Aligned protoplanet orbits with very similar eccentricity to that of the gas disc are found to undergo litle eccentricity change while undergoing inward migration in general. However, for significantly larger orbital eccentricities, migration may be significantly reduced or even reverse from inwards to outwards. Thus the existence of global non circular motions in discs with radial excursions comparable to the semi-thickness may have important consequences for the migration and survival of protoplanetary cores in the earth mass range.

  12. Bulk Migration of Ni/NiO in Ni-YSZ during Reducing Conditions

    SciTech Connect (OSTI)

    Saraf, Laxmikant V.; Baer, Donald R.; Lea, Alan S.; Zhu, Zihua; Strohm, James J.; Sitzman, S. D.; King, David L.

    2010-02-09T23:59:59.000Z

    Understanding the migration of Ni/NiO in Ni-YSZ can potentially help to design a better solid oxide fuel cell (SOFC) anode. We have observed that extensive hydrogen reduction and methane steam reforming of Ni-YSZ caused bulk migration of Ni/NiO to at least ~ 5 µm deeper from the Ni-YSZ surface. No significant bulk migration effects were detected after simple thermal treatments in non-reducing/non-reforming environment. Surface analysis of a single zirconia grain in the first 10-20 nm region from annealed, hydrogen reduced and methane steam reformed Ni-YSZ shows Ni-enriched surface supporting earlier claims of Ni exsolution. 3D-EBSD analysis of thermally treated sample before exposing it to reducing and reforming environment indicated mixed NiO/YSZ phase with some porosity and random grain orientation. The surface analysis and mapping were carried out using ToF-SIMS and AES whereas EDS maps on FIB sliced areas on Ni-YSZ were utilized for the bulk analysis. The results provide additional information related to complex reactions occurring in SOFC during internal reforming conditions.

  13. Summary Results for Brine Migration Modeling Performed by LANL LBNL and SNL for the UFD Program

    SciTech Connect (OSTI)

    Kuhlman, Kristopher L

    2014-09-01T23:59:59.000Z

    This report summarizes laboratory and field observations and numerical modeling related to coupled processes involving brine and vapor migration in geologic salt, focusing on recent developments and studies conducted at Sandia, Los Alamos, and Berkeley National Laboratories. Interest into the disposal of heat-generating waste in salt has led to interest into water distribution and migration in both run-of-mine crushed and intact geologic salt. Ideally a fully coupled thermal-hydraulic-mechanical-chemical simulation is performed using numerical models with validated constitutive models and parameters. When mechanical coupling is not available, mechanical effects are prescribed in hydraulic models as source, boundary, or initial conditions. This report presents material associated with developing appropriate initial conditions for a non-mechanical hydrologic simulation of brine migration in salt. Due to the strong coupling between the mechanical and hydrologic problems, the initial saturation will be low for the excavation disturbed zone surrounding the excavation. Although most of the material in this report is not new, the author hopes it is presented in a format making it useful to other salt researchers.

  14. Syntectonic hydrocarbon migration and accumulation in Miley Reservoir, Rincon field, Ventura County, California

    SciTech Connect (OSTI)

    Nelson, D.E.; Harrison, R.A.

    1987-05-01T23:59:59.000Z

    The Miley reservoir of the Rincon field is located in the Central Transverse Ranges of southern California on a structural high that borders the Santa Barbara Channel. The east-west-trending Rincon and Ventura anticlines are part of a major oil-productive trend containing the Rincon, San Miguelito, and Ventura Avenue fields, which have estimated ultimate recovery of 1.7 billion BOE. Hydrocarbon accumulations in the multiple and stacked reservoirs within these three fields are controlled by the complex interplay of late Pleistocene folding and reverse fault development. The detailed interpretation reported here combines reservoir performance data with subsurface structural geology and sequential tectonic development to provide a new understanding of the relationship of migration barriers to oil accumulation and production. The Miley reservoir is an axial- and fault-controlled accumulation on the eastern terminus of the Rincon anticline. It is located in a structural saddle formed by the doubly plunging Rincon and Ventura anticlinal trend. Three operative trapping mechanisms confine oil pools: (1) axial accumulations associated with reverse fault closures; (2) traps on the hanging wall of dip-slip reverse faults; and (3) a permeability barrier developed in response to flexural slip folding. Oil trapped within the Rincon-Miley reservoir was primarily generated beneath the Santa Barbara Channel and migrated up the south flank of the anticlinal trend. Four stages of structural development and hydrocarbon migration, encompassing the last 700,000 years, have implications for the enhanced development of reservoirs on this anticlinal trend.

  15. Survival Estimates for the Passage of Spring-Migrating Juvenile Salmonids through Snake and Columbia River Dams and Reservoirs, 2005-2006 Annual Report.

    SciTech Connect (OSTI)

    Smith, Steven G.; Muir, William D.; Marsh, Douglas M. (National Marine Fisheries Service, Northwest Fisheries Science Center, Fish Ecology Division, Seattle, WA)

    2006-05-01T23:59:59.000Z

    In 2005, the National Marine Fisheries Service and the University of Washington completed the thirteenth year of a study to estimate survival and travel time of juvenile salmonids Oncorhynchus spp. passing through dams and reservoirs on the Snake and Columbia Rivers. All estimates were derived from detections of fish tagged with passive integrated transponder tags (PIT tags). We PIT tagged and released a total of 18,439 hatchery steelhead, 5,315 wild steelhead, and 6,964 wild yearling Chinook salmon at Lower Granite Dam in the Snake River. In addition, we utilized fish PIT tagged by other agencies at traps and hatcheries upstream from the hydropower system and at sites within the hydropower system in both the Snake and Columbia Rivers. PIT-tagged smolts were detected at interrogation facilities at Lower Granite, Little Goose, Lower Monumental, Ice Harbor, McNary, John Day, and Bonneville Dams and in the PIT-tag detector trawl operated in the Columbia River estuary. Survival estimates were calculated using a statistical model for tag-recapture data from single release groups (the ''single-release model''). Primary research objectives in 2005 were: (1) Estimate reach survival and travel time in the Snake and Columbia Rivers throughout the migration period of yearling Chinook salmon O. tshawytscha and steelhead O. mykiss. (2) Evaluate relationships between survival estimates and migration conditions. (3) Evaluate the survival estimation models under prevailing conditions. This report provides reach survival and travel time estimates for 2005 for PIT-tagged yearling Chinook salmon (hatchery and wild), hatchery sockeye salmon O. nerka, hatchery coho salmon O. kisutch, and steelhead (hatchery and wild) in the Snake and Columbia Rivers. Additional details on the methodology and statistical models used are provided in previous reports cited here.

  16. Study of T cell activation and migration at the single-cell and single-molecule level

    E-Print Network [OSTI]

    Chang, Irene Yin-Ting

    2011-01-01T23:59:59.000Z

    T cells are required by their immunological roles to recirculate in the body and migrate to tissue sites, a journey that exposes them to distorting forces and physical obstacles that hinder their movement. Therefore, they ...

  17. Interfacial oxygen migration and its effect on the magnetic anisotropy in Pt/Co/MgO/Pt films

    SciTech Connect (OSTI)

    Chen, Xi; Feng, Chun, E-mail: fengchun@ustb.edu.cn, E-mail: ghyu@mater.ustb.edu.cn; Liu, Yang; Jiang, Shaolong; Hua Li, Ming; Hua Yu, Guang, E-mail: fengchun@ustb.edu.cn, E-mail: ghyu@mater.ustb.edu.cn [Department of Materials Physics and Chemistry, University of Science and Technology Beijing, Beijing 100083 (China); Long Wu, Zheng [Analytical and Testing Center, Beijing Normal University, Beijing 100875 (China); Yang, Feng [State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Beijing 102249 (China)

    2014-02-03T23:59:59.000Z

    This paper reports the interfacial oxygen migration effect and its induced magnetic anisotropy evolution in Pt/Co/MgO/Pt films. During depositing the MgO layer, oxygen atoms from the MgO combine with the neighboring Co atoms, leading to the formation of CoO at the Co/MgO interface. Meanwhile, the films show in-plane magnetic anisotropy (IMA). After annealing, most of the oxygen atoms in CoO migrate back to the MgO layer, resulting in obvious improvement of Co/MgO interface and the enhancement of effective Co-O orbital hybridization. These favor the evolution of magnetic anisotropy from IMA to perpendicular magnetic anisotropy (PMA). The oxygen migration effect is achieved by the redox reaction at the Co/MgO interface. On the contrary, the transfer from IMA to PMA cannot be observed in Pt/Co/Pt films due to the lack of interfacial oxygen migration.

  18. Diel vertical migration: Ecological controls and impacts on the biological pump in a one-dimensional ocean model

    E-Print Network [OSTI]

    Devernal, Anne

    of nutrients, carbon, and oxygen in the water column. Excretion, fecal pellet production, and mortality and productivity across the biomes, including the biomass of migrating organisms. We estimate that realistic

  19. E-Print Network 3.0 - alternative pathways precedes Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    alternative pathways with many dif... structure formation Figure 2 Pathways of protein folding. In the framework model, precedence is given... 1936-122X080609-048920.00 Key...

  20. Reasoning about the ERK signal transduction pathway using BioSigNet-RR

    E-Print Network [OSTI]

    Baral, Chitta

    Reasoning about the ERK signal transduction pathway using BioSigNet-RR Carron Shanklanda , Nam. In this paper we present a preliminary report on describing a a simple network (the ERK pathway of [4]) using

  1. Reasoning about the ERK signal transduction pathway using BioSigNetRR

    E-Print Network [OSTI]

    Shankland, Carron

    Reasoning about the ERK signal transduction pathway using BioSigNet­RR Carron Shankland a , Nam network (the ERK pathway of [CSK + 03]) using the declarative language of the tool BioSigNet­RR [BCT + 04

  2. Getting from here to there – energy technology transformation pathways in the EMF-27 scenarios

    SciTech Connect (OSTI)

    Krey, Volker; Luderer, Gunnar; Clarke, Leon E.; Kriegler, Elmar

    2014-04-01T23:59:59.000Z

    This apper discusses Getting from here to there – energy technology transformation pathways in the EMF-27 scenarios

  3. Illegal Pathways to Illegal Profits: The Big Cigarette Companies and International Smuggling

    E-Print Network [OSTI]

    Campaign for Tobacco-Free Kids

    2003-01-01T23:59:59.000Z

    Illegal Pathwaysto Illegal Profits The Big Cigarette Companies andfor Tobacco-Free Kids Illegal Pathways to Illegal Profits

  4. Gas pile-up, gap overflow, and Type 1.5 migration in circumbinary disks: general theory

    E-Print Network [OSTI]

    Bence Kocsis; Zoltan Haiman; Abraham Loeb

    2012-09-13T23:59:59.000Z

    Many astrophysical binaries, from planets to black holes, exert strong torques on their circumbinary accretion disks, and are expected to significantly modify the disk structure. Despite the several decade long history of the subject, the joint evolution of the binary + disk system has not been modeled with self-consistent assumptions for arbitrary mass ratios and accretion rates. Here we solve the coupled binary-disk evolution equations analytically in the strongly perturbed limit, treating the azimuthally-averaged angular momentum exchange between the disk and the binary and the modifications to the density, scale-height, and viscosity self-consistently, including viscous and tidal heating, diffusion limited cooling, radiation pressure, and the orbital decay of the binary. We find a solution with a central cavity and a migration rate similar to those previously obtained for Type-II migration, applicable for large masses and binary separations, and near-equal mass ratios. However, we identify a distinct new regime, applicable at smaller separations and masses, and mass ratio in the range 0.001piles up outside the binary's orbit, but rather than creating a cavity, it continuously overflows as in a porous dam. The disk profile is intermediate between a weakly perturbed disk (producing Type-I migration) and a disk with a gap (with Type-II migration). However, the migration rate of the secondary is typically slower than both Type-I and Type-II rates. We term this new regime "Type-1.5" migration.

  5. Export Pathway Selectivity of Escherichia coli Twin Arginine Translocation Signal Peptides*S

    E-Print Network [OSTI]

    Palmer, Tracy

    Export Pathway Selectivity of Escherichia coli Twin Arginine Translocation Signal Peptides exported via the twin arginine translocation (Tat) path- way. Fusions of the putative Tat signal peptides peptides to direct export through the Tat pathway, through the general secretory pathway (Sec), or through

  6. The role of Erk MAPK pathway in CD4 T cell proliferation and differentiation

    E-Print Network [OSTI]

    Chang, Chiung-Fang

    2011-01-01T23:59:59.000Z

    B. (2010). Key role of ERK pathway signaling in lupus.and Hedrick, S.M. The role of Erk MAPK pathway in CD4 T cellTHE DISSERTATION The role of Erk MAPK pathway in CD4 T cell

  7. Polymer Uncrossing and Knotting in Protein Folding, and Their Role in Minimal Folding Pathways

    E-Print Network [OSTI]

    Plotkin, Steven S.

    Polymer Uncrossing and Knotting in Protein Folding, and Their Role in Minimal Folding Pathways Ali induce dominant pathway mechanisms in protein folding. Citation: Mohazab AR, Plotkin SS (2013) Polymer Uncrossing and Knotting in Protein Folding, and Their Role in Minimal Folding Pathways. PLoS ONE 8(1): e53642

  8. Using Bit-Vector Decision Procedures for Analysis of Protein Folding Pathways

    E-Print Network [OSTI]

    Langmead, Christopher James

    Using Bit-Vector Decision Procedures for Analysis of Protein Folding Pathways Christopher James-vector decision procedures for the analysis of protein folding pathways. We argue that the protein fold- ing by the different nature of the protein folding problem, we present a translation of the protein folding pathways

  9. Brian Giebel Subject: FW: Faculty positions in Plant Genomics and Pathway Engineering at the JGI

    E-Print Network [OSTI]

    Borenstein, Elhanan

    1 Brian Giebel Subject: FW: Faculty positions in Plant Genomics and Pathway Engineering at the JGI: Faculty positions in Plant Genomics and Pathway Engineering at the JGI To: Jay Shendure coming out in Science targeted at recruiting individuals in plant genomics and pathway engineering

  10. Managing site remediation using pathway analysis, application to a semi-arid site

    SciTech Connect (OSTI)

    Rutz, E.E.; Ijaz, T.; Wood, R.P.; Eckart, R.E. [Univ. of Cincinnati, OH (United States). Dept. of Mechanical, Industrial and Nuclear Engineering

    1993-12-31T23:59:59.000Z

    This paper discusses the application of pathway analysis methodology to evaluate alternatives associated with remediation of a semi-arid site. Significant aspects of remediation include potential land uses, soil cleaning techniques and restoration alternatives. Important environmental transport pathways and dominant radionuclides are identified using pathway analysis. The remediation strategy is optimized based on results of the analysis.

  11. Development of an Ingestion Pathway Model for AXAIRQ

    SciTech Connect (OSTI)

    Simpkins, A.A.

    1999-01-13T23:59:59.000Z

    AXAIRQ is a dose mode code used for prospective accident assessment at the Savannah River Site and is primarily used to show regulatory compliance. For completeness of pathway analysis, an ingestion model, AXINGST, has been developed for use with, and incorporation in, AXAIRQ. Currently available ingestion models were referenced as a basis for AXINGST. AXINGST calculates a conservative ingestion dose following an atmospheric release of radionuclides and includes site specific variables where applicable.

  12. Cytotoxicological Response to Engineered Nanomaterials: A Pathway-Driven Process

    E-Print Network [OSTI]

    Romoser, Amelia Antonia

    2012-07-16T23:59:59.000Z

    to deal with the ?insult? of the nanoparticle exposure by activating Nrf-2, a key transcription 10 factor involved in upregulating antioxidant genes, or the exposure may trigger more of an inflammatory response, in which NF-?B plays a role. A... disturbance of the cellular redox equilibrium and subsequent oxidative stress has been shown to trigger multiple stress pathways and transcription factors of redox-sensitive nature, such as nuclear factor-erythroid 2-p45?related factor 2 (Nrf2), which...

  13. Commercial Building Design Pathways Using Optimization Analysis: Preprint

    SciTech Connect (OSTI)

    Long, N.; Hirsch, A.; Lobato, C.; Macumber, D.

    2010-08-01T23:59:59.000Z

    Whole-building simulation and analysis has demonstrated a significant energy savings potential in a wide variety of design projects. Commercial building design, however, traditionally integrates simulation and modeling analyses too late in the design process to make a substantial impact on energy use. The National Renewable Energy Laboratory (NREL) commercial building group created an optimization platform called Opt-E-Plus that uses multivariate and multi-objective optimization theory to navigate a large parameter space and find economically valid, energy-saving solutions. The analysis results provide designers and engineers valuable information that influences the design. The pathways are not full 'construction ready' design alternatives; rather, they offer guidance about performance and cost criteria to reach a range of energy and economic goals. Having this knowledge early in the design phase helps designers establish project goals and direct the design pathway before they make important decisions. Opt-E-Plus has been deployed on several projects, including a retrofit mixed-use building, a new NREL office building, and several nationwide design guides. Each of these projects had different design criteria, goals, and audiences. In each case the analysis results provided pathways that helped inform the design process.

  14. Reduction of metastasis, cell invasion, and adhesion in mouse osteosarcoma by YM529/ONO-5920-induced blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathway

    SciTech Connect (OSTI)

    Tsubaki, Masanobu [Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi-Osaka 577-8502 (Japan)] [Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi-Osaka 577-8502 (Japan); Satou, Takao; Itoh, Tatsuki [Department of Pathology, Kinki University School of Medicine, Osakasayama, Osaka 589-8511 (Japan)] [Department of Pathology, Kinki University School of Medicine, Osakasayama, Osaka 589-8511 (Japan); Imano, Motohiro [Department of Surgery, Kinki University School of Medicine, Osakasayama, Osaka 589-8511 (Japan)] [Department of Surgery, Kinki University School of Medicine, Osakasayama, Osaka 589-8511 (Japan); Ogaki, Mitsuhiko [Department of Pharmacy, Higahiosaka City General Hospital, Higashi-osaka, Osaka 578-8588 (Japan)] [Department of Pharmacy, Higahiosaka City General Hospital, Higashi-osaka, Osaka 578-8588 (Japan); Yanae, Masashi [Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi-Osaka 577-8502 (Japan) [Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi-Osaka 577-8502 (Japan); Depeartment of Pharmacy, Sakai Hospital, Kinki University School of Medicine, Sakai, Osaka 590-0132 (Japan); Nishida, Shozo, E-mail: nishida@phar.kindai.ac.jp [Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi-Osaka 577-8502 (Japan)] [Division of Pharmacotherapy, Kinki University School of Pharmacy, Kowakae, Higashi-Osaka 577-8502 (Japan)

    2012-03-15T23:59:59.000Z

    Osteosarcoma is one of the most common primary malignant bone tumors in children and adolescents. Some patients continue to have a poor prognosis, because of the metastatic disease. YM529/ONO-5920 is a nitrogen-containing bisphosphonate that has been used for the treatment of osteoporosis. YM529/ONO-5920 has recently been reported to induce apoptosis in various tumors including osteosarcoma. However, the mode of metastasis suppression in osteosarcoma by YM529/ONO-5920 is unclear. In the present study, we investigated whether YM529/ONO-5920 inhibited tumor cell migration, invasion, adhesion, or metastasis in the LM8 mouse osteosarcoma cell line. We found that YM529/ONO-5920 significantly inhibited metastasis, cell migration, invasion, and adhesion at concentrations that did not have antiproliferative effects on LM8 cells. YM529/ONO-5920 also inhibited the mRNA expression and protein activities of matrix metalloproteinases (MMPs). In addition, YM529/ONO-5920 suppressed phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2) and the serine/threonine protein kinase B (Akt) by the inhibition of Ras prenylation. Moreover, U0126, a mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor, and LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, also inhibited LM8 cell migration, invasion, adhesion, and metastasis, as well as the mRNA expression and protein activities of MMP-1, MMP-2, MMP-9, and MT1-MMP. The results indicated that YM529/ONO-5920 suppressed the Ras/MEK/ERK and Ras/PI3K/Akt pathways, thereby inhibiting LM8 cell migration, invasion, adhesion, and metastasis. These findings suggest that YM529/ONO-5920 has potential clinical applications for the treatment of tumor cell metastasis in osteosarcoma. -- Highlights: ? We investigated whether YM529/ONO-5920 inhibited tumor metastasis in osteosarcoma. ? YM529/ONO-5920 inhibited metastasis, cell migration, invasion, and adhesion. ? YM529/ONO-5920 suppressed Ras signalings. ? YM529/ONO-5920 has potential clinical applications for the treatment in osteosarcoma.

  15. Short- and Long- Time Transport Structures in a Three Dimensional Time Dependent Flow

    E-Print Network [OSTI]

    Rodolphe Chabreyrie; Stefan G. Llewellyn Smith

    2014-05-08T23:59:59.000Z

    Lagrangian transport structures for three-dimensional and time-dependent fluid flows are of great interest in numerous applications, particularly for geophysical or oceanic flows. In such flows, chaotic transport and mixing can play important environmental and ecological roles, for examples in pollution spills or plankton migration. In such flows, where simulations or observations are typically available only over a short time, understanding the difference between short-time and long-time transport structures is critical. In this paper, we use a set of classical (i.e. Poincar\\'e section, Lyapunov exponent) and alternative (i.e. finite time Lyapunov exponent, Lagrangian coherent structures) tools from dynamical systems theory that analyze chaotic transport both qualitatively and quantitatively. With this set of tools we are able to reveal, identify and highlight differences between short- and long-time transport structures inside a flow composed of a primary horizontal contra-rotating vortex chain, small lateral oscillations and a weak Ekman pumping. The difference is mainly the existence of regular or extremely slowly developing chaotic regions that are only present at short time.

  16. Some effects of data base variations on numerical simulations of uranium migration

    SciTech Connect (OSTI)

    Carnahan, C.L.

    1987-12-01T23:59:59.000Z

    Numerical simulations of migration of chemicals in the geosphere depend on knowledge of identities of chemical species and on values of chemical equilibrium constants supplied to the simulators. In this work, some effects of variability in assumed speciation and in equilibrium constants were examined, using migration of uranium as an example. Various simulations were done of uranium migration in systems with varying oxidation potential, pH, and mator component content. A simulation including formation of aqueous species UO/sub 2//sup 2 +/, UO/sub 2/CO/sub 3//sup 0/, UO/sub 2/(CO/sub 3/)/sub 2//sup 2 -/, UO/sub 2/(CO/sub 3/)/sub 3//sup 4 -/, (UO/sub 2/)/sub 2/CO/sub 3/(OH)/sub 3//sup -/, UO/sub 2//sup +/, U(OH)/sub 4//sup 0/, and U(OH)/sub 5//sup -/ is compared to simulation excluding formation of UO/sub 2//sup +/ and U(OH)/sub 5//sup -/. These simulations relied on older data bases, and they are compared to a further simulation using recently published data on formation of U(OH)/sub 4//sup 0/, (UO/sub 2/)/sub 2/CO/sub 3/(OH)/sub 3//sup -/, UO/sub 2/(CO/sub 3/)/sub 5//sup 5 -/, and U(CO/sub 3/)/sub 5//sup 6 -/. Significant differences in dissolved uranium concentrations are noted among the simulations. Differences are noted also in precipitation of two solids, USiO/sub 4/(c) (coffinite) and CaUO/sub 4/(c) (calcium uranate), although the solubility products of the solids were not varied in the simulations. 18 refs., 9 figs., 2 tabs.

  17. Modelling and Numerical Simulation of Gas Migration in a Nuclear Waste Repository

    E-Print Network [OSTI]

    Bourgeat, Alain; Smai, Farid

    2010-01-01T23:59:59.000Z

    We present a compositional compressible two-phase, liquid and gas, flow model for numerical simulations of hydrogen migration in deep geological radioactive waste repository. This model includes capillary effects and the gas diffusivity. The choice of the main variables in this model, Total or Dissolved Hydrogen Mass Concentration and Liquid Pressure, leads to a unique and consistent formulation of the gas phase appearance and disappearance. After introducing this model, we show computational evidences of its adequacy to simulate gas phase appearance and disappearance in different situations typical of underground radioactive waste repository.

  18. Emergence and Persistence of Collective Cell Migration on Small Circular Micropatterns

    E-Print Network [OSTI]

    Segerer, Felix J; Alberola, Alicia Piera; Frey, Erwin; Rädler, Joachim O

    2015-01-01T23:59:59.000Z

    The spontaneous formation of vortices is a hallmark of collective cellular activity. Here, we study the onset and persistence of coherent angular motion (CAMo) as a function of the number of cells $N$ confined in circular micropatterns. We find that the persistence of CAMo increases with $N$ but exhibits a pronounced discontinuity accompanied by a geometric rearrangement of cells to a configuration containing a central cell. Computer simulations based on a generalized Potts model reproduce the emergence of vortex states and show in agreement with experiment that their stability depends on the interplay of spatial arrangement and internal polarization of neighboring cells. Hence, the distinct migrational states in finite size

  19. Migration of the ATLAS Metadata Interface (AMI) to Web 2.0 and cloud

    E-Print Network [OSTI]

    Odier, Jerome; The ATLAS collaboration; Fulachier, Jerome; Lambert, Fabian

    2015-01-01T23:59:59.000Z

    The ATLAS Metadata Interface (AMI) can be considered to be a mature application because it has existed for at least 10 years. Over the last year, we have been adapting the application to some recently available technologies. The web interface, which previously manipulated XML documents using XSL transformations, has been migrated to Asynchronous Java Script (AJAX). Web development has been considerably simplified by the development of a framework for AMI based on JQuery and Twitter Bootstrap. Finally there has been a major upgrade of the python web service client.

  20. A cost-benefit analysis of rural-urban migration decisions in less developed countries

    E-Print Network [OSTI]

    Aste-Salazar, Juan Gerardo

    1973-01-01T23:59:59.000Z

    A COST-Bier'vlT ANAL&&! q O, ' RUR&M -URBAN M1 G -'-', ". ' !ON DECISIONS IN LESS DEUDLOl'ED COUNTRIES A. Thesis By JUAN GERARDO ASTL'-SALAZAR Submitted to the Graduate College of Tezas A&N University in partial fulfillment of the requirement...] suggests a method to obtain information on rural-urban dr:ift which xcay b. . used in government planning. TJ;ia thcois follows the format of Tha Azericen J:conom'~o B 0, '& . '. s;. '. migration has been examined by economists in the past, g and it has...