National Library of Energy BETA

Sample records for mi elevation profile

  1. PROJECT PROFILE: Elevate Energy | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Elevate Energy educates residential real estate agents, appraisers, and appraiser regulatory officials about solar energy systems through web-based, continuing education classes. ...

  2. Repression of miR-17-5p with elevated expression of E2F-1 and c-MYC in non-metastatic hepatocellular carcinoma and enhancement of cell growth upon reversing this expression pattern

    SciTech Connect (OSTI)

    El Tayebi, H.M.; Omar, K.; Hegy, S.; El Maghrabi, M.; El Brolosy, M.; Hosny, K.A.; Esmat, G.; Abdelaziz, A.I.

    2013-05-10

    Highlights: The oncogenic miR-17-5p is downregulated in non-metastatic hepatocellular carcinoma patients. E2F-1 and c-MYC transcripts are upregulated in non-metastatic HCC patients. miR-17-5p forced overexpression inhibited E2F-1 and c-MYC expression in HuH-7 cells. miR-17-5p mimicking increased HuH-7 cell growth, proliferation, migration and colony formation. miR-17-5p is responsible for HCC progression among the c-MYC/E2F-1/miR-17-5p triad members. -- Abstract: E2F-1, c-MYC, and miR-17-5p is a triad of two regulatory loops: a negative and a positive loop, where c-MYC induces the expression of E2F-1 that induces the expression of miR-17-5p which in turn reverses the expression of E2F-1 to close the loop. In this study, we investigated this triad for the first time in hepatocellular carcinoma (HCC), where miR-17-5p showed a significant down-regulation in 23 non-metastatic HCC biopsies compared to 10 healthy tissues; however, E2F-1 and c-MYC transcripts were markedly elevated. Forced over-expression of miR-17-5p in HuH-7 cells resulted in enhanced cell proliferation, growth, migration and clonogenicity with concomitant inhibition of E2F-1 and c-MYC transcripts expressions, while antagomirs of miR-17-5p reversed these events. In conclusion, this study revealed a unique pattern of expression for miR-17-5p in non-metastatic HCC patients in contrast to metastatic HCC patients. In addition we show that miR-17-5p is the key player among the triad that tumor growth and spread.

  3. Profiling

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Profiling your application with Intel VTune at NERSC --- 1 --- VTune background and availability * Focus: O n---node p erformance a nalysis - Sampling a nd t race---based p rofiling - Performance c ounter i ntegra8on - Memory b andwidth a nalysis - On---node p arallelism: vectoriza8on a nd t hreading * Pre---defined a nalysis e xperiments * GUI a nd c ommand---line i nterface ( good f or h eadless collec?on a nd l ater a nalysis) * NERSC a vailability ( as t he vtune m odule) - Edison ( Dual 1

  4. Characterization of function and regulation of miR-24-1 and miR-31

    SciTech Connect (OSTI)

    Sun Fenyong; Wang Jiayi; Pan Qiuhui; Yu Yongchun; Zhang Yue; Wan Yang; Wang Ju; Li Xiaoyan; Hong An

    2009-03-13

    To date, numerous microRNAs (miRNAs) have been discovered. However, the function of these miRNAs is largely unknown. While our knowledge of miRNA post-transcriptional processing has greatly expanded in recent years, we have a limited understanding of the regulation and transcription of miRNA genes. In this study, we characterized two BMP-2 upregulated miRNAs, miR-24-1 and miR-31, in mesenchymal stem cells and showed their opposing function in controlling cellular proliferation, and adipogenesis. Furthermore, we are the first to identify and characterize mouse intronic miR-23b{approx}27b{approx}24-1 and intergenic miR-31 genes. Moreover, we found that pri-miR-23b, pri-miR-27b, and pri-miR-24-1 are transcribed independently and their expression profiles are unique when cells are treated with BMP-2, even though they are located closely together.

  5. Measurement of the direct <mi>CP> -violating parameter <mi>Ami><mi>CP> in the decay <mi>D>+<mi>Kmi>-<mimi>+<mi>π>+

    SciTech Connect (OSTI)

    Abazov, V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Agnew, J. P.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Askew, A.; Atkins, S.; Augsten, K.; Avila, C.; Badaud, F.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, S.; Barberis, E.; Baringer, P.; Bartlett, J. F.; Bassler, U.; Bazterra, V.; Bean, A.; Begalli, M.; Bellantoni, L.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; Besançon, M.; Beuselinck, R.; Bhat, P. C.; Bhatia, S.; Bhatnagar, V.; Blazey, G.; Blessing, S.; Bloom, K.; Boehnlein, A.; Boline, D.; Boos, E. E.; Borissov, G.; Borysova, M.; Brandt, A.; Brandt, O.; Brock, R.; Bross, A.; Brown, D.; Bu, X. B.; Buehler, M.; Buescher, V.; Bunichev, V.; Burdin, S.; Buszello, C. P.; Camacho-Pérez, E.; Casey, B. C. K.; Castilla-Valdez, H.; Caughron, S.; Chakrabarti, S.; Chan, K. M.; Chandra, A.; Chapon, E.; Chen, G.; Cho, S. W.; Choi, S.; Choudhary, B.; Cihangir, S.; Claes, D.; Clutter, J.; Cooke, M.; Cooper, W. E.; Corcoran, M.; Couderc, F.; Cousinou, M. -C.; Cutts, D.; Das, A.; Davies, G.; de Jong, S. J.; De La Cruz-Burelo, E.; Déliot, F.; Demina, R.; Denisov, D.; Denisov, S. P.; Desai, S.; Deterre, C.; DeVaughan, K.; Diehl, H. T.; Diesburg, M.; Ding, P. F.; Dominguez, A.; Dubey, A.; Dudko, L. V.; Duperrin, A.; Dutt, S.; Eads, M.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Enari, Y.; Evans, H.; Evdokimov, V. N.; Fauré, A.; Feng, L.; Ferbel, T.; Fiedler, F.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Fortner, M.; Fox, H.; Fuess, S.; Garbincius, P. H.; Garcia-Bellido, A.; García-González, J. A.; Gavrilov, V.; Geng, W.; Gerber, C. E.; Gershtein, Y.; Ginther, G.; Gogota, O.; Golovanov, G.; Grannis, P. D.; Greder, S.; Greenlee, H.; Grenier, G.; Gris, Ph.; Grivaz, J. -F.; Grohsjean, A.; Grünendahl, S.; Grünewald, M. W.; Guillemin, T.; Gutierrez, G.; Gutierrez, P.; Haley, J.; Han, L.; Harder, K.; Harel, A.; Hauptman, J. M.; Hays, J.; Head, T.; Hebbeker, T.; Hedin, D.; Hegab, H.; Heinson, A. P.; Heintz, U.; Hensel, C.; Heredia-De La Cruz, I.; Herner, K.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hoang, T.; Hobbs, J. D.; Hoeneisen, B.; Hogan, J.; Hohlfeld, M.; Holzbauer, J. L.; Howley, I.; Hubacek, Z.; Hynek, V.; Iashvili, I.; Ilchenko, Y.; Illingworth, R.; Ito, A. S.; Jabeen, S.; Jaffré, M.; Jayasinghe, A.; Jeong, M. S.; Jesik, R.; Jiang, P.; Johns, K.; Johnson, E.; Johnson, M.; Jonckheere, A.; Jonsson, P.; Joshi, J.; Jung, A. W.; Juste, A.; Kajfasz, E.; Karmanov, D.; Katsanos, I.; Kaur, M.; Kehoe, R.; Kermiche, S.; Khalatyan, N.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. N.; Kiselevich, I.; Kohli, J. M.; Kozelov, A. V.; Kraus, J.; Kumar, A.; Kupco, A.; Kurča, T.; Kuzmin, V. A.; Lammers, S.; Lebrun, P.; Lee, H. S.; Lee, S. W.; Lee, W. M.; Lei, X.; Lellouch, J.; Li, D.; Li, H.; Li, L.; Li, Q. Z.; Lim, J. K.; Lincoln, D.; Linnemann, J.; Lipaev, V. V.; Lipton, R.; Liu, H.; Liu, Y.; Lobodenko, A.; Lokajicek, M.; Lopes de Sa, R.; Luna-Garcia, R.; Lyon, A. L.; Maciel, A. K. A.; Madar, R.; Magaña-Villalba, R.; Malik, S.; Malyshev, V. L.; Mansour, J.; Martínez-Ortega, J.; McCarthy, R.; McGivern, C. L.; Meijer, M. M.; Melnitchouk, A.; Menezes, D.; Mercadante, P. G.; Merkin, M.; Meyer, A.; Meyer, J.; Miconi, F.; Mondal, N. K.; Mulhearn, M.; Nagy, E.; Narain, M.; Nayyar, R.; Neal, H. A.; Negret, J. P.; Neustroev, P.; Nguyen, H. T.; Nunnemann, T.; Orduna, J.; Osman, N.; Osta, J.; Pal, A.; Parashar, N.; Parihar, V.; Park, S. K.; Partridge, R.; Parua, N.; Patwa, A.; Penning, B.; Perfilov, M.; Peters, Y.; Petridis, K.; Petrillo, G.; Pétroff, P.; Pleier, M. -A.; Podstavkov, V. M.; Popov, A. V.; Prewitt, M.; Price, D.; Prokopenko, N.; Qian, J.; Quadt, A.; Quinn, B.; Ratoff, P. N.; Razumov, I.; Ripp-Baudot, I.; Rizatdinova, F.; Rominsky, M.; Ross, A.; Royon, C.; Rubinov, P.; Ruchti, R.; Sajot, G.; Sánchez-Hernández, A.; Sanders, M. P.; Santos, A. S.; Savage, G.; Savitskyi, M.; Sawyer, L.; Scanlon, T.; Schamberger, R. D.; Scheglov, Y.; Schellman, H.; Schwanenberger, C.; Schwienhorst, R.; Sekaric, J.; Severini, H.; Shabalina, E.; Shary, V.; Shaw, S.; Shchukin, A. A.; Simak, V.; Skubic, P.; Slattery, P.; Smirnov, D.; Snow, G. R.; Snow, J.; Snyder, S.; Söldner-Rembold, S.; Sonnenschein, L.; Soustruznik, K.; Stark, J.; Stoyanova, D. A.; Strauss, M.; Suter, L.; Svoisky, P.; Titov, M.; Tokmenin, V. V.; Tsai, Y. -T.; Tsybychev, D.; Tuchming, B.; Tully, C.; Uvarov, L.; Uvarov, S.; Uzunyan, S.; Van Kooten, R.; van Leeuwen, W. M.; Varelas, N.; Varnes, E. W.; Vasilyev, I. A.; Verkheev, A. Y.; Vertogradov, L. S.; Verzocchi, M.; Vesterinen, M.; Vilanova, D.; Vokac, P.; Wahl, H. D.; Wang, M. H. L. S.; Warchol, J.; Watts, G.; Wayne, M.; Weichert, J.; Welty-Rieger, L.; Williams, M. R. J.; Wilson, G. W.; Wobisch, M.; Wood, D. R.; Wyatt, T. R.; Xie, Y.; Yamada, R.; Yang, S.; Yasuda, T.; Yatsunenko, Y. A.; Ye, W.; Ye, Z.; Yin, H.; Yip, K.; Youn, S. W.; Yu, J. M.; Zennamo, J.; Zhao, T. G.; Zhou, B.; Zhu, J.; Zielinski, M.; Zieminska, D.; Zivkovic, L.

    2014-12-01

    We measure the direct mi>Cmi>mi>P>-violating parameter mi>Ami>mi>Cmi>mi>Pmi> for the decay of the charged charm meson, mi>Dmi>+mi>Kmi>-mi>πmi>+mi>πmi>+ (and charge conjugate), using the full 10.4 mi>fbmi>-1 sample of mi>p>mi>p>¯ collisions at mi>smi>=1.96 mi>TeVmi> collected by the D0 detector at the Fermilab Tevatron collider. We extract the raw reconstructed charge asymmetry by fitting the invariant mass distributions for the sum and difference of charge-specific samples. This quantity is then corrected for detector-related asymmetries using data-driven methods and for possible physics asymmetries (from mi>B>mi>D

  6. ELEVATING MECHANISM

    DOE Patents [OSTI]

    Frederick, H.S.; Kinsella, M.A.

    1959-02-24

    An elevator is described, which is arranged for movement both in a horizontal and in a vertical direction so that the elevating mechanism may be employed for servicing equipment at separated points in a plant. In accordance with the present invention, the main elevator chassis is suspended from a monorail. The chassis, in turn supports a vertically moveable carriage, a sub- carriage vertically moveable on the carriage, and a turntable carried by the sub- carriage and moveable through an arc of 90 with the equipment attached thereto. In addition, the chassis supports all the means required to elevate or rotate the equipment.

  7. miR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7

    SciTech Connect (OSTI)

    Zhou, Chuanyi; Shen, Liangfang; Mao, Lei; Wang, Bing; Li, Yang; Yu, Huizhi

    2015-02-27

    MicroRNAs (miRNAs) are involved in the cervical carcinogenesis and progression. In this study, we investigated the role of miR-92a in progression and invasion of cervical cancer. MiR-92a was significantly upregulated in cervical cancer tissues and cell lines. Overexpression of miR-92a led to remarkably enhanced proliferation by promoting cell cycle transition from G1 to S phase and significantly enhanced invasion of cervical cancer cells, while its knockdown significantly reversed these cellular events. Bioinformatics analysis suggested F-box and WD repeat domain-containing 7 (FBXW7) as a novel target of miR-92a, and miR-92a suppressed the expression level of FBXW7 mRNA by direct binding to its 3′-untranslated region (3′UTR). Expression of miR-92a was negatively correlated with FBXW7 in cervical cancer tissues. Furthermore, Silencing of FBXW7 counteracted the effects of miR-92a suppression, while its overexpression reversed oncogenic effects of miR-92a. Together, these findings indicate that miR-92a acts as an onco-miRNA and may contribute to the progression and invasion of cervical cancer, suggesting miR-92a as a potential novel diagnostic and therapeutic target of cervical cancer. - Highlights: • miR-92a is elevated in cervical cancer tissues and cell lines. • miR-92a promotes cervical cancer cell proliferation, cell cycle transition from G1 to S phase and invasion. • FBXW7 is a direct target of miR-92a. • FBXW7 counteracts the oncogenic effects of miR-92a on cervical cancer cells.

  8. Real-time sub-<mi>>ngstrom...

    Office of Scientific and Technical Information (OSTI)

    Real-time sub-<mi>>ngstrom imaging of reversible and irreversible conformations in rhodium catalysts and graphene Kisielowski, Christian; Wang,...

  9. miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation

    SciTech Connect (OSTI)

    Mizuno, Yosuke; Yagi, Ken; Tokuzawa, Yoshimi; Kanesaki-Yatsuka, Yukiko; Suda, Tatsuo; Katagiri, Takenobu; Fukuda, Toru; Maruyama, Masayoshi; Okuda, Akihiko; Amemiya, Tomoyuki; Kondoh, Yasumitsu; Tashiro, Hideo; Okazaki, Yasushi

    2008-04-04

    Although various microRNAs regulate cell differentiation and proliferation, no miRNA has been reported so far to play an important role in the regulation of osteoblast differentiation. Here we describe the role of miR-125b in osteoblastic differentiation in mouse mesenchymal stem cells, ST2, by regulating cell proliferation. The expression of miR-125b was time-dependently increased in ST2 cells, and the increase in miR-125b expression was attenuated in osteoblastic-differentiated ST2 cells induced by BMP-4. The transfection of exogenous miR-125b inhibited proliferation of ST2 cells and caused inhibition of osteoblastic differentiation. In contrast, when the endogenous miR-125b was blocked by transfection of its antisense RNA molecule, alkaline phosphatase activity after BMP-4 treatment was elevated. These results strongly suggest that miR-125b is involved in osteoblastic differentiation through the regulation of cell proliferation.

  10. Mi GmbH | Open Energy Information

    Open Energy Info (EERE)

    Mi GmbH Jump to: navigation, search Name: Mi GmbH Place: Switzerland Zip: CH-6340 Sector: Solar Product: Baar-based manufacturer and distributor of fruit juices. The firm is also...

  11. miR-196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells

    SciTech Connect (OSTI)

    Zhang, Jie; Zheng, Fangxia; Yu, Gang; Yin, Yanhua; Lu, Qingyang

    2013-11-01

    Highlights: miR-196a was overexpressed in cervical cancer tissue compared to normal tissue. miR-196a expression elevated proliferation and migration of cervical cancer cells. miR-196a inhibited NTN4 expression by binding 3?-UTR region of NTN4 mRNA. NTN4 inversely correlated with miR-196a expression in cervical tissue and cell line. NTN4 expression was low in cervical cancer tissue compared to normal tissue. -- Abstract: Recent research has uncovered tumor-suppressive and oncogenic potential of miR-196a in various tumors. However, the expression and mechanism of its function in cervical cancer remains unclear. In this study, we assess relative expression of miR-196a in cervical premalignant lesions, cervical cancer tissues, and four cancer cell lines using quantitative real-time PCR. CaSki and HeLa cells were treated with miR-196a inhibitors, mimics, or pCDNA/miR-196a to investigate the role of miR-196a in cancer cell proliferation and migration. We demonstrated that miR-196a was overexpressed in cervical intraepithelial neoplasia 23 and cervical cancer tissue. Moreover, its expression contributes to the proliferation and migration of cervical cancer cells, whereas inhibiting its expression led to a reduction in proliferation and migration. Five candidate targets of miR-196a chosen by computational prediction and Cervical Cancer Gene Database search were measured for their mRNA in both miR-196a-overexpressing and -depleted cancer cells. Only netrin 4 (NTN4) expression displayed an inverse association with miR-196a. Fluorescent reporter assays revealed that miR-196a inhibited NTN4 expression by targeting one binding site in the 3?-untranslated region (3?-UTR) of NTN4 mRNA. Furthermore, qPCR and Western blot assays verified NTN4 expression was downregulated in cervical cancer tissues compared to normal controls, and in vivo mRNA level of NTN4 inversely correlated with miR-196a expression. In summary, our findings provide new insights about the functional role of

  12. miRNAs in brain development

    SciTech Connect (OSTI)

    Petri, Rebecca; Malmevik, Josephine; Fasching, Liana; Åkerblom, Malin; Jakobsson, Johan

    2014-02-01

    MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer and DGCR8, have demonstrated a crucial role for miRNAs during the development of the central nervous system. Furthermore, mice deleted for specific miRNAs and miRNA-clusters demonstrate diverse functional roles for different miRNAs during the development of different brain structures. miRNAs have been proposed to regulate cellular functions such as differentiation, proliferation and fate-determination of neural progenitors. In this review we summarise the findings from recent studies that highlight the importance of miRNAs in brain development with a focus on the mouse model. We also discuss the technical limitations of current miRNA studies that still limit our understanding of this family of non-coding RNAs and propose the use of novel and refined technologies that are needed in order to fully determine the impact of specific miRNAs in brain development. - Highlights: • miRNAs are essential for brain development and neuronal function. • KO of Dicer is embryonically lethal. • Conditional Dicer KO results in defective proliferation or increased apoptosis. • KO of individual miRNAs or miRNA families is necessary to determine function.

  13. Temperature-profile detector

    DOE Patents [OSTI]

    Not Available

    1981-01-29

    Temperature profiles at elevated temperature conditions are monitored by use of an elongated device having two conductors spaced by the minimum distance required to normally maintain an open circuit between them. The melting point of one conductor is selected at the elevated temperature being detected, while the melting point of the other is higher. As the preselected temperature is reached, liquid metal will flow between the conductors creating short circuits which are detectable as to location.

  14. Temperature profile detector

    DOE Patents [OSTI]

    Tokarz, Richard D.

    1983-01-01

    Temperature profiles at elevated temperature conditions are monitored by use of an elongated device having two conductors spaced by the minimum distance required to normally maintain an open circuit between them. The melting point of one conductor is selected at the elevated temperature being detected, while the melting point of the other is higher. As the preselected temperature is reached, liquid metal will flow between the conductors, creating short circuits which are detectable as to location.

  15. DOE - Office of Legacy Management -- Michigan Velsicol Chemical Corp - MI

    Office of Legacy Management (LM)

    03 Michigan Velsicol Chemical Corp - MI 03 FUSRAP Considered Sites Site: MICHIGAN [VELSICOL] CHEMICAL CORP. (MI.03 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Velsicol Chemical Corp. MI.03-1 Location: St. Louis , Michigan MI.03-2 Evaluation Year: Circa 1987 MI.03-3 Site Operations: Rare earth processing facility. MI.03-2 Site Disposition: Eliminated - No Authority - NRC survey MI.03-3 Radioactive Materials Handled: Yes Primary Radioactive

  16. DOE - Office of Legacy Management -- Star Cutter Corp - MI 15

    Office of Legacy Management (LM)

    Star Cutter Corp - MI 15 FUSRAP Considered Sites Site: STAR CUTTER CORP. (MI.15) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Farmington , Michigan MI.15-1 Evaluation Year: 1991 MI.15-2 Site Operations: Performed a one time uranium slug drilling operation test in 1956. MI.15-3 MI.15-1 Site Disposition: Eliminated - Potential for contamination considered remote based on limited scope and quantity of materials handled MI.15-2 Radioactive

  17. Ionizing Radiation–Inducible miR-27b Suppresses Leukemia Proliferation via Targeting Cyclin A2

    SciTech Connect (OSTI)

    Wang, Bo; Li, Dongping; Kovalchuk, Anna; Litvinov, Dmitry; Kovalchuk, Olga

    2014-09-01

    Purpose: Ionizing radiation is a common carcinogen that is important for the development of leukemia. However, the underlying epigenetic mechanisms remain largely unknown. The goal of the study was to explore microRNAome alterations induced by ionizing radiation (IR) in murine thymus, and to determine the role of IR-inducible microRNA (miRNA/miR) in the development of leukemia. Methods and Materials: We used the well-established C57BL/6 mouse model and miRNA microarray profiling to identify miRNAs that are differentially expressed in murine thymus in response to irradiation. TIB152 human leukemia cell line was used to determine the role of estrogen receptor–α (ERα) in miR-27b transcription. The biological effects of ectopic miR-27b on leukemogenesis were measured by western immunoblotting, cell viability, apoptosis, and cell cycle analyses. Results: Here, we have shown that IR triggers the differential expression of miR-27b in murine thymus tissue in a dose-, time- and sex-dependent manner. miR-27b was significantly down-regulated in leukemia cell lines CCL119 and TIB152. Interestingly, ERα was overexpressed in those 2 cell lines, and it was inversely correlated with miR-27b expression. Therefore, we used TIB152 as a model system to determine the role of ERα in miR-27b expression and the contribution of miR-27b to leukemogenesis. β-Estradiol caused a rapid and transient reduction in miR-27b expression reversed by either ERα-neutralizing antibody or ERK1/2 inhibitor. Ectopic expression of miR-27b remarkably suppressed TIB152 cell proliferation, at least in part, by inducing S-phase arrest. In addition, it attenuated the expression of cyclin A2, although it had no effect on the levels of PCNA, PPARγ, CDK2, p21, p27, p-p53, and cleaved caspase-3. Conclusion: Our data reveal that β-estradiol/ERα signaling may contribute to the down-regulation of miR-27b in acute leukemia cell lines through the ERK1/2 pathway, and that miR-27b may function as a tumor

  18. DOE - Office of Legacy Management -- Wolverine Tube Division - MI 05

    Office of Legacy Management (LM)

    Wolverine Tube Division - MI 05 FUSRAP Considered Sites Site: Wolverine Tube Division (MI.05) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Wolverine Tube Division of Calumet & Hecla Consolidated Copper Co. Star Tool Hermes Automotive Manufacturing Corporation MI.05-1 MI.05-2 Location: 1411 Central Avenue , Detroit , Michigan MI.05-3 Evaluation Year: 1990 MI.05-2 Site Operations: 1943 - Conducted research and development of methods for spinning

  19. DOE - Office of Legacy Management -- Adrian - MI 01

    Office of Legacy Management (LM)

    Adrian - MI 01 FUSRAP Considered Sites Adrian, MI Alternate Name(s): Bridgeport Brass Co. Special Metals Extrusion Plant Bridgeport Brass Company General Motors General Motors Company, Adrian MI.01-1 Location: 1450 East Beecher Street, Adrian, Michigan MI.01-3 Historical Operations: Performed uranium extrusion research and development and metal fabrication work for the AEC using uranium, thorium, and plutonium. MI.01-2 Eligibility Determination: Eligible MI.01-1 Radiological Survey(s):

  20. DOE - Office of Legacy Management -- Carboloy Co - MI 12

    Office of Legacy Management (LM)

    Carboloy Co - MI 12 FUSRAP Considered Sites Site: Carboloy Co. (MI.12 ) Eliminated from further consideration under FUSRAP - AEC licensed facility Designated Name: Not Designated Alternate Name: General Electric MI.12-1 Location: 11177 E. Eight Mile Road , Detroit , Michigan MI.12-1 MI.12-2 Evaluation Year: 1987-1991 MI.12-3 MI.12-4 MI.12-6 Site Operations: Turned-down the outer diameter of uranium metal slugs and conducted pilot plant scale operations for hot pressing uranium dioxide pellets

  1. Elevance Pilot-Scale Biorefinery

    Broader source: Energy.gov [DOE]

    The Elevance biorefinery uses catalyst technology to produce fuels and chemicals from renewable, natural oils.

  2. Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation

    SciTech Connect (OSTI)

    Chen, Chao; Wu, Chao-Qun; Zhang, Zong-Qi; Yao, Ding-Kang; Zhu, Liang

    2011-07-15

    Activation and migration of resident stellate cells (HSCs) within the hepatic space of Disse play an important role in hepatic fibrosis, which accounts for the increased numbers of activated HSCs in areas of inflammation during hepatic fibrosis. Currently, microRNAs have been found to play essential roles in HSC differentiation, proliferation, apoptosis, fat accumulation and collagen production. However, little is known about microRNA mediated HSC activation and migration. In this study, the miRNA expression profiles of quiescent HSCs, partially activated HSCs and fully activated HSCs were compared in pairs. Gene ontology (GO) and GO-Map network analysis indicated that the activation of HSCs was regulated by microRNAs. Among them miR-335 was confirmed to be significantly reduced during HSC activation by qRT-PCR, and restoring expression of miR-335 inhibited HSC migration and reduced {alpha}-SMA and collagen type I. Previous study revealed that tenascin-C (TNC), an extracellular matrix glycoprotein involved in cell migration, might be a target of miR-335. Therefore, we further studied the TNC expression in miR-335 over-expressed HSCs. Our data showed that exogenous TNC could enhance HSC migration in vitro and miR-335 restoration resulted in a significant inhibition of TNC expression. These results demonstrated that miR-335 restoration inhibited HSC migration, at least in part, via downregulating the TNC expression.

  3. Roles of miRNAs in microcystin-LR-induced Sertoli cell toxicity

    SciTech Connect (OSTI)

    Zhou, Yuan; Wang, Hui; Wang, Cong; Qiu, Xuefeng; Benson, Mikael; Yin, Xiaoqin; Xiang, Zou; Li, Dongmei; and others

    2015-08-15

    Microcystin (MC)-LR, a cyclic heptapeptide, is a potent reproductive system toxin. To understand the molecular mechanisms of MC-induced reproductive system cytotoxicity, we evaluated global changes of miRNA and mRNA expression in mouse Sertoli cells following MC-LR treatment. Our results revealed that the exposure to MC-LR resulted in an altered miRNA expression profile that might be responsible for the modulation of mRNA expression. Bio-functional analysis indicated that the altered genes were involved in specific cellular processes, including cell death and proliferation. Target gene analysis suggested that junction injury in Sertoli cells exposed to MC-LR might be mediated by miRNAs through the regulation of the Sertoli cell-Sertoli cell pathway. Collectively, these findings may enhance our understanding on the modes of action of MC-LR on mouse Sertoli cells as well as the molecular mechanisms underlying the toxicity of MC-LR on the male reproductive system. - Highlights: • miRNAs were altered in Sertoli cells exposed to MC-LR. • Alerted genes were involved in different cell functions including the cell morphology. • MC-LR adversely affected Sertoli cell junction formation through the regulating miRNAs.

  4. DOE - Office of Legacy Management -- Oliver Corp - MI 11

    Office of Legacy Management (LM)

    Oliver Corp - MI 11 FUSRAP Considered Sites Site: OLIVER CORP. (MI.11 ) Eliminated from further consideration under FUSRAP - Referred to NRC Designated Name: Not Designated Alternate Name: Behnke Warehousing Incorporated MI.11-1 Location: 433 East Michigan Avenue , Battle Creek , Michigan MI.11-1 Evaluation Year: 1986 MI.11-4 Site Operations: Conducted production scale briquetting of green salt and magnesium blend under AEC license Nos. SNM-591, SUB-579, and C-3725. MI.11-1 MI.11-3 Site

  5. The NuMI Neutrino Beam

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Adamson, P.; Anderson, K.; Andrews, M.; Andrews, R.; Anghel, I.; Augustine, D.; Aurisano, A.; Avvakumov, S.; Ayres, D. S.; Baller, B.; et al

    2015-10-20

    Our paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important part of our design details pertaining to individual components is described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.

  6. DOE - Office of Legacy Management -- Detrex Corp - MI 10

    Office of Legacy Management (LM)

    Detrex Corp - MI 10 FUSRAP Considered Sites Site: Detrex Corp. (MI.10 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Detroit , Michigan MI.10-1 Evaluation Year: 1987 MI.10-2 Site Operations: Conducted experimental runs relative to pickling/degreasing of one handful of uranium turnings MI.10-1 Site Disposition: Eliminated - Potential for contamination considered remote due to small quantity of material handled - There is no

  7. Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro

    SciTech Connect (OSTI)

    Deng, Jun; Lei, Wan; Fu, Jian-Chun; Zhang, Ling; Li, Jun-He; Xiong, Jian-Ping

    2014-01-17

    Highlight: MiR-21 plays a significant role in 5-FU resistance. This role might be attributed to targeting of hMSH2 as well as TP and DPD via miR-21 targeted hMSH2. Indirectly targeted TP and DPD to influence 5-FU chemotherapy sensitivity. -- Abstract: 5-Fluorouracil (5-FU) is a classic chemotherapeutic drug that has been widely used for colorectal cancer treatment, but colorectal cancer cells are often resistant to primary or acquired 5-FU therapy. Several studies have shown that miR-21 is significantly elevated in colorectal cancer. This suggests that this miRNA might play a role in this resistance. In this study, we investigated this possibility and the possible mechanism underlying this role. We showed that forced expression of miR-21 significantly inhibited apoptosis, enhanced cell proliferation, invasion, and colony formation ability, promoted G1/S cell cycle transition and increased the resistance of tumor cells to 5-FU and X radiation in HT-29 colon cancer cells. Furthermore, knockdown of miR-21 reversed these effects on HT-29 cells and increased the sensitivity of HT-29/5-FU to 5-FU chemotherapy. Finally, we showed that miR-21 targeted the human mutS homolog2 (hMSH2), and indirectly regulated the expression of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD). These results demonstrate that miR-21 may play an important role in the 5-FU resistance of colon cancer cells.

  8. DOE - Office of Legacy Management -- Naval Ordnance Plant - MI...

    Office of Legacy Management (LM)

    Eliminated from further consideration under FUSRAP - Referred to DoD for action Designated ... MI.0-03-1 Site Disposition: Eliminated - No Authority - Referred to DoD MI.0-03-1 ...

  9. miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor

    SciTech Connect (OSTI)

    Park, Jong-Kook; Henry, Jon C.; Jiang, Jinmai; Esau, Christine; Gusev, Yuriy; Lerner, Megan R.; Postier, Russell G.; Brackett, Daniel J.; Schmittgen, Thomas D.

    2011-03-25

    Research highlights: {yields} The expression of miR-132 and miR-212 are significantly increased in pancreatic cancer. {yields} miR-132 and miR-212 target the tumor suppressor pRb, resulting in enhanced proliferation. {yields} miR-132 and miR-212 expression is increased by a {beta}2 adrenergic receptor agonist, suggesting a novel mechanism for pancreatic cancer progression. -- Abstract: Numerous microRNAs (miRNAs) are reported as differentially expressed in cancer, however the consequence of miRNA deregulation in cancer is unknown for many miRNAs. We report that two miRNAs located on chromosome 17p13, miR-132 and miR-212, are over-expressed in pancreatic adenocarcinoma (PDAC) tissues. Both miRNAs are predicted to target the retinoblastoma tumor suppressor, Rb1. Validation of this interaction was confirmed by luciferase reporter assay and western blot in a pancreatic cancer cell line transfected with pre-miR-212 and pre-miR-132 oligos. Cell proliferation was enhanced in Panc-1 cells transfected with pre-miR-132/-212 oligos. Conversely, antisense oligos to miR-132/-212 reduced cell proliferation and caused a G{sub 2}/M cell cycle arrest. The mRNA of a number of E2F transcriptional targets were increased in cells over expressing miR-132/-212. Exposing Panc-1 cells to the {beta}2 adrenergic receptor agonist, terbutaline, increased the miR-132 and miR-212 expression by 2- to 4-fold. We report that over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells and that the increase in cell proliferation from over-expression of these miRNAs is likely due to increased expression of several E2F target genes. The {beta}2 adrenergic pathway may play an important role in this novel mechanism.

  10. “Nodal Gap” induced by the incommensurate diagonal spin density modulation in underdoped high- <mi>Tmi>c> superconductors

    SciTech Connect (OSTI)

    Zhou, Tao; Gao, Yi; Zhu, Jian -Xin

    2015-03-07

    Recently it was revealed that the whole Fermi surface is fully gapped for several families of underdoped cuprates. The existence of the finite energy gap along the <mi>d>-wave nodal lines (nodal gap) contrasts the common understanding of the <mi>d>-wave pairing symmetry, which challenges the present theories for the high-<mi>Tmi><mi>c>superconductors. Here we propose that the incommensurate diagonal spin-density-wave order can account for the above experimental observation. The Fermi surface and the local density of states are also studied. Our results are in good agreement with many important experiments in high-<mi>Tmi><mi>c>superconductors.

  11. People Profiles

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    people profiles People Profiles Featured Profile Hye-Sook Park Pursuing a challenging-and rewarding-career Read More » Henry Hui Henry Hui Tanza Lewis Tanza Lewis Jamie King Jamie King Lisa Burrows Lisa Burrows Jeremy Huckins Jeremy Huckins Ibo Matthews Ibo Matthews Peter Thelin Peter Thelin Susanna Reyes Susana Reyes Jerry Britten Jerry Britten Reggie Drachenberg Reggie Drachenberg Beth Dzenitis Beth Dzenitis Rebecca Dylla-Spears Rebecca Dylla-Spears John Heebner John Heebner Terry Land Terry

  12. Actinide Thermodynamics at Elevated Temperatures

    SciTech Connect (OSTI)

    Friese, Judah I.; Rao, Linfeng; Xia, Yuanxian; Bachelor, Paula P.; Tian, Guoxin

    2007-11-16

    The postclosure chemical environment in the proposed Yucca Mountain repository is expected to experience elevated temperatures. Predicting migration of actinides is possible if sufficient, reliable thermodynamic data on hydrolysis and complexation are available for these temperatures. Data are scarce and scattered for 25 degrees C, and nonexistent for elevated temperatures. This collaborative project between LBNL and PNNL collects thermodynamic data at elevated temperatures on actinide complexes with inorganic ligands that may be present in Yucca Mountain. The ligands include hydroxide, fluoride, sulfate, phosphate and carbonate. Thermodynamic parameters of complexation, including stability constants, enthalpy, entropy and heat capacity of complexation, are measured with a variety of techniques including solvent extraction, potentiometry, spectrophotometry and calorimetry

  13. DOE - Office of Legacy Management -- Dow Chemical Co - Midland - MI 06

    Office of Legacy Management (LM)

    Midland - MI 06 FUSRAP Considered Sites Site: Dow Chemical Co. - Midland (MI.06 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Midland , Michigan MI.06-1 Evaluation Year: Circa 1987 MI.06-2 Site Operations: Conducted development work for production of magnesium-thorium alloys. MI.06-1 Site Disposition: Eliminated - AEC licensed site MI.06-1 MI.06-2 Radioactive Materials Handled: Yes Primary Radioactive Materials Handled:

  14. Boulder County- Elevations Energy Loans

    Broader source: Energy.gov [DOE]

    Elevations Credit Union has partnered with Boulder County and the City/County of Denver to offer this full-suite of services. Both EnergySmart and the Denver Energy Challenge help residents and b...

  15. DOE - Office of Legacy Management -- General Motors Co - Flint - MI 07

    Office of Legacy Management (LM)

    Motors Co - Flint - MI 07 FUSRAP Considered Sites Site: GENERAL MOTORS CO. (MI.07 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: A.C. Spark Plug Dort Highway Plant MI.07-1 MI.07-2 Location: Flint , Michigan MI.07-1 Evaluation Year: 1987 MI.07-3 Site Operations: Processed thorium oxide, uranium oxide, and beryllium oxide into crucibles for the Chicago Area. MI.07-3 MI.07-4 MI.07-5 Site Disposition: Eliminated - Potential for contamination

  16. MINOS Experiment and NuMI Beam Home Page

    Broader source: All U.S. Department of Energy (DOE) Office Webpages

    NuMI-MINOS Neutrino Logo NuMI Beamline and MINOS Experiment Neutrino Logo The MINOS Experiment and NuMI Beamline Fermilab Logo MINOS Experiment Links ◊ MINOS for the Public ◊ Scientific Results ◊ MINOS at Work ◊ NuMI at Work ◊ MINOS+ Experiment Fermilab Neutrino Links ◊ Neutrino FAQ ◊ MINOS Underground Areas at Fermilab ◊ PPD Intensity Frontier Dept Back to - - - ◊ Fermilab at Work ◊ Fermilab Home the MINOS Far Detector in the Soudan Mine MINOS collaborators assembling the

  17. Magnetocrystalline anisotropy in <mi>UMn>2<mi>Ge>2 and related Mn-based actinide ferromagnets

    SciTech Connect (OSTI)

    Parker, David S.; Ghimire, Nirmal; Singleton, John; Thompson, J. D.; Bauer, Eric D.; Baumbach, Ryan; Mandrus, David; Li, Ling; Singh, David J.

    2015-05-04

    We present magnetization isotherms in pulsed magnetic fields up to 62 Tesla, supported by first principles calculations, demonstrating a huge uniaxial magnetocrystalline anisotropy energy - approximately 20 MJ/m3 - in <mi>UMn>2<mi>Ge>2. This large anisotropy results from the extremely strong spin-orbit coupling affecting the uranium 5 f electrons, which in the calculations exhibit a substantial orbital moment exceeding 2 μB. Finally, we also find from theoretical calculations that a number of isostructural Mn-actinide compounds are expected to have similarly large anisotropy.

  18. ,"Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf...

    U.S. Energy Information Administration (EIA) Indexed Site

    ,"Worksheet Name","Description"," Of Series","Frequency","Latest Data for" ,"Data 1","Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2014 ,"Release...

  19. Elevance Renewable Sciences Inc | Open Energy Information

    Open Energy Info (EERE)

    Elevance Renewable Sciences Inc Jump to: navigation, search Name: Elevance Renewable Sciences Inc Place: Bolingbrook, Illinois Zip: 60440 Sector: Biofuels, Renewable Energy...

  20. Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells

    SciTech Connect (OSTI)

    Vrba, Lukas; Jensen, Taylor J.; Garbe, James C.; Heimark, Ronald L.; Cress, Anne E.; Dickinson, Sally; Stampfer, Martha R.; Futscher, Bernard W.

    2009-12-23

    BACKGROUND: The microRNA-200 family participates in the maintenance of an epithelial phenotype and loss of its expression can result in epithelial to mesenchymal transition (EMT). Furthermore, the loss of expression of miR-200 family members is linked to an aggressive cancer phenotype. Regulation of the miR-200 family expression in normal and cancer cells is not fully understood. METHODOLOGY/ PRINCIPAL FINDINGS: Epigenetic mechanisms participate in the control of miR-200c and miR-141 expression in both normal and cancer cells. A CpG island near the predicted mir-200c/mir-141 transcription start site shows a striking correlation between miR-200c and miR-141 expression and DNA methylation in both normal and cancer cells, as determined by MassARRAY technology. The CpG island is unmethylated in human miR-200/miR-141 expressing epithelial cells and in miR-200c/miR-141 positive tumor cells. The CpG island is heavily methylated in human miR-200c/miR-141 negative fibroblasts and miR-200c/miR-141 negative tumor cells. Mouse cells show a similar inverse correlation between DNA methylation and miR-200c expression. Enrichment of permissive histone modifications, H3 acetylation and H3K4 trimethylation, is seen in normal miR-200c/miR-141-positive epithelial cells, as determined by chromatin immunoprecipitation coupled to real-time PCR. In contrast, repressive H3K9 dimethylation marks are present in normal miR-200c/miR-141-negative fibroblasts and miR-200c/miR-141 negative cancer cells and the permissive histone modifications are absent. The epigenetic modifier drug, 5-aza-2'-deoxycytidine, reactivates miR-200c/miR-141 expression showing that epigenetic mechanisms play a functional role in their transcriptional control. CONCLUSIONS/ SIGNIFICANCE: We report that DNA methylation plays a role in the normal cell type-specific expression of miR-200c and miR-141 and this role appears evolutionarily conserved, since similar results were obtained in mouse. Aberrant DNA methylation of the

  1. miR-92a family and their target genes in tumorigenesis and metastasis

    SciTech Connect (OSTI)

    Li, Molin; Guan, Xingfang; Sun, Yuqiang; Mi, Jun; Shu, Xiaohong; Liu, Fang; Li, Chuangang

    2014-04-15

    The miR-92a family, including miR-25, miR-92a-1, miR-92a-2 and miR-363, arises from three different paralog clusters miR-17-92, miR-106a-363, and miR-106b-25 that are highly conservative in the process of evolution, and it was thought as a group of microRNAs (miRNAs) correlated with endothelial cells. Aberrant expression of miR-92a family was detected in multiple cancers, and the disturbance of miR-92a family was related with tumorigenesis and tumor development. In this review, the progress on the relationship between miR-92a family and their target genes and malignant tumors will be summarized. - Highlights: Aberrant expression of miR-92a, miR-25 and miR-363 can be observed in many kinds of malignant tumors. The expression of miR-92a family is regulated by LOH, epigenetic alteration, transcriptional factors such as SP1, MYC, E2F, wild-type p53 etc. Roles of miR-92a family in tumorigenesis and development: promoting cell proliferation, invasion and metastasis, inhibiting cell apoptosis.

  2. DOE - Office of Legacy Management -- Baker-Perkins Co - MI 13

    Office of Legacy Management (LM)

    Baker-Perkins Co - MI 13 FUSRAP Considered Sites Site: Baker-Perkins Co (MI 13) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Saginaw , Michigan MI.13-1 Evaluation Year: 1991 MI.13-1 MI.13-2 Site Operations: Small scale oxide mixing demonstrations and testing in May, 1956. MI.13-2 Site Disposition: Eliminated - Potential for contamination remote based on limited scope of activities at the site MI.13-3 Radioactive Materials Handled: Yes

  3. DOE - Office of Legacy Management -- Revere Copper and Brass Co - MI 04

    Office of Legacy Management (LM)

    Revere Copper and Brass Co - MI 04 FUSRAP Considered Sites Site: REVERE COPPER AND BRASS CO. ( MI.04 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Revere Copper and Brass MI.04-1 Location: 5851 West Jefferson Street , Detroit , Michigan MI.04-1 Evaluation Year: 1990 MI.04-2 Site Operations: Extrusion of tuballoy rods, myrnalloy rods and beryllium shapes in the 1940s. MI.04-3 MI.04-4 Site Disposition: Eliminated - Radiation levels below criteria

  4. MPI Profiling

    SciTech Connect (OSTI)

    Han, D K; Jones, T R

    2005-02-11

    The Message Passing Interface (MPI) is the de facto message-passing standard for massively parallel programs. It is often the case that application performance is a crucial factor, especially for solving grand challenge problems. While there have been many studies on the scalability of applications, there have not been many focusing on the specific types of MPI calls being made and their impact on application performance. Using a profiling tool called mpiP, a large spectrum of parallel scientific applications were surveyed and their performance results analyzed.

  5. miR-17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression

    SciTech Connect (OSTI)

    Gao, Yong; Luo, Ling-hui; Li, Shuai; Yang, Cao

    2014-02-07

    Highlights: • miR-17 was increased in OS tissues and cell lines. • Inhibition of miR-17 suppressed OS cell proliferation. • Inhibition of miR-17 suppressed OS cell migration and invasion. • PTEN was a target of miR-17. • miR-17 was negatively correlated with PTEN in OS tissues. - Abstract: MicroRNAs (miRNAs) play essential roles in cancer development and progression. Here, we investigated the role of miR-17 in the progression and metastasis of osteosarcoma (OS). miR-17 was frequently increased in OS tissues and cell lines. Inhibition of miR-17 in OS cell lines substantially suppressed cell proliferation, migration, and invasion. Phosphatase and tensin homolog (PTEN) was identified as a target of miR-17, and ectopic expression of miR-17 inhibited PTEN by direct binding to its 3′-untranslated region (3′-UTR). Expression of miR-17 was negatively correlated with PTEN in OS tissues. Together, these findings indicate that miR-17 acts as an oncogenic miRNA and may contribute to the progression and metastasis of OS, suggesting miR-17 as a potential novel diagnostic and therapeutic target of OS.

  6. MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications

    SciTech Connect (OSTI)

    Lu, Ying-fei; Zhang, Li; Waye, Mary Miu Yee; Fu, Wei-ming; Zhang, Jin-fang

    2015-05-15

    MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers. - Highlights: • miR-218 is frequently down regulated in multiple cancers. • miR-218 plays pivotal roles in carcinogenesis. • miR-218 mediates proliferation, apoptosis, metastasis, invasion, etc. • miR-218 mediates tumorigenesis and metastasis via multiple pathways.

  7. DOE - Office of Legacy Management -- Dow-Detroit Edison Project - MI 0-02

    Office of Legacy Management (LM)

    Dow-Detroit Edison Project - MI 0-02 FUSRAP Considered Sites Site: Dow-Detroit Edison Project (MI.0-02 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Detroit , Michigan MI.0-02-1 Evaluation Year: 1987 MI.0-02-1 Site Operations: Performed reference design work for a special fast breeder type reactor. MI.0-02-1 Site Disposition: Eliminated - No radioactive material handled at the site MI.0-02-1 Radioactive Materials Handled: No

  8. DOE - Office of Legacy Management -- Mitts-Merrill Co - MI 14

    Office of Legacy Management (LM)

    Mitts-Merrill Co - MI 14 FUSRAP Considered Sites Site: MITTS and MERRILL CO. (MI.14 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Genessee Packing Co. MI.14-1 Location: Saginaw, Michigan MI.14-1 Evaluation Year: 1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces on a small test scale during the mid-1950s. MI.14-1 Site Disposition: Eliminated - Potential for contamination considered remote based on limited quantity

  9. FEMA - National Flood Insurance Program Elevation Certificate...

    Open Energy Info (EERE)

    and Instructions Jump to: navigation, search OpenEI Reference LibraryAdd to library Web Site: FEMA - National Flood Insurance Program Elevation Certificate and Instructions...

  10. miRNA-205 affects infiltration and metastasis of breast cancer

    SciTech Connect (OSTI)

    Wang, Zhouquan; Department of Tumor, SenGong Hospital of Shaanxi, Xian 710300 ; Liao, Hehe; Deng, Zhiping; Yang, Po; Du, Ning; Zhanng, Yunfeng; Ren, Hong

    2013-11-08

    Highlights: We detected expression of miR-205 in breast cancer cell lines and tissue samples. We suggest miR-205 is downregulated in human breast cancer tissues and MCF7 cells. We suggest the lower expression of miR-205 play a role in breast cancer onset. These data suggest that miR-205 directly targets HER3 in human breast cancer. -- Abstract: Background: An increasing number of studies have shown that miRNAs are commonly deregulated in human malignancies, but little is known about the function of miRNA-205 (miR-205) in human breast cancer. The present study investigated the influence of miR-205 on breast cancer malignancy. Methods: The expression level of miR-205 in the MCF7 breast cancer cell line was determined by quantitative (q)RT-PCR. We then analyzed the expression of miR-205 in breast cancer and paired non-tumor tissues. Finally, the roles of miR-205 in regulating tumor proliferation, apoptosis, migration, and target gene expression were studied by MTT assay, flow cytometry, qRT-PCR, Western blotting and luciferase assay. Results: miR-205 was downregulated in breast cancer cells or tissues compared with normal breast cell lines or non-tumor tissues. Overexpression of miR-205 reduced the growth and colony-formation capacity of MCF7 cells by inducing apoptosis. Overexpression of miR-205 inhibited MCF7 cell migration and invasiveness. By bioinformation analysis, miR-205 was predicted to bind to the 3? untranslated regions of human epidermal growth factor receptor (HER)3 mRNA, and upregulation of miR-205 reduced HER3 protein expression. Conclusion: miR-205 is a tumor suppressor in human breast cancer by post-transcriptional inhibition of HER3 expression.

  11. NuMI Low Energy Flux Prediction Release

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NuMI Low Energy Flux Prediction Release Neutrino Flux Predictions for the NuMI Beam hep-ex/1607.00704 Data Ancillary data files for this result are available on arXiv at http://arxiv.org/src/1607.00704/anc.< /li> Among the available data files are: pdf file describing format of all the available files root file of all the available fluxes python code to read and process MINERvA's flux predictions Text Files of the flux, uncertainties, and covariance matrix, with units of neutrinos/m^2/POT,

  12. Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    (Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 1 2014 1 1 1 1 2 1 1 1 1 1 2015 1 1 1 1 1 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 08/31/2016 Next Release Date: 09/30/2016 Referring Pages: U.S. Liquefied Natural Gas Exports by Point of Exit Port Huron, MI LNG Exports to All Countries

  13. Ground Motion Studies at NuMI

    SciTech Connect (OSTI)

    Mayda M. Velasco; Michal Szleper

    2012-02-20

    Ground motion can cause significant deterioration in the luminosity of a linear collider. Vibration of numerous focusing magnets causes continuous misalignments, which makes the beam emittance grow. For this reason, understanding the seismic vibration of all potential LC sites is essential and related efforts in many sites are ongoing. In this document we summarize the results from the studies specific to Fermilab grounds as requested by the LC project leader at FNAL, Shekhar Mishra in FY04-FY06. The Northwestern group focused on how the ground motion effects vary with depth. Knowledge of depth dependence of the seismic activity is needed in order to decide how deep the LC tunnel should be at sites like Fermilab. The measurements were made in the NuMI tunnel, see Figure 1. We take advantage of the fact that from the beginning to the end of the tunnel there is a height difference of about 350 ft and that there are about five different types of dolomite layers. The support received allowed to pay for three months of salary of Michal Szleper. During this period he worked a 100% of his time in this project. That include one week of preparation: 2.5 months of data taking and data analysis during the full period of the project in order to guarantee that we were recording high quality data. We extended our previous work and made more systematic measurements, which included detailed studies on stability of the vibration amplitudes at different depths over long periods of time. As a consequence, a better control and more efficient averaging out of the daytime variation effects were possible, and a better study of other time dependences before the actual depth dependence was obtained. Those initial measurements were made at the surface and are summarized in Figure 2. All measurements are made with equipment that we already had (two broadband seismometers KS200 from GEOTECH and DL-24 portable data recorder). The offline data analysis took advantage of the full Fourier spectra

  14. DOE - Office of Legacy Management -- Mitts-Merrel Co - MI 14

    Office of Legacy Management (LM)

    1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces ... Primary Radioactive Materials Handled: Thorium MI.14-1 Radiological Survey(s): Yes - ...

  15. MiR-125a TNF receptor-associated factor 6 to inhibit osteoclastogenesis

    SciTech Connect (OSTI)

    Guo, Li-Juan; Liao, Lan; Yang, Li; Li, Yu; Jiang, Tie-Jian

    2014-02-15

    MicroRNAs (miRNAs) play important roles in osteoclastogenesis and bone resorption. In the present study, we found that miR-125a was dramatically down-regulated during macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) induced osteoclastogenesis of circulating CD14+ peripheral blood mononuclear cells (PBMCs). Overexpression of miR-125a in CD14+ PBMCs inhibited osteoclastogenesis, while inhibition of miR-125a promoted osteoclastogenesis. TNF receptor-associated factor 6 (TRAF6), a transduction factor for RANKL/RANK/NFATc1 signal, was confirmed to be a target of miR-125a. EMSA and ChIP assays confirmed that NFATc1 bound to the promoter of the miR-125a. Overexpression of NFATc1 inhibited miR-125a transcription, and block of NFATc1 expression attenuated RANKL-regulated miR-125a transcription. Here, we reported that miR-125a played a biological function in osteoclastogenesis through a novel TRAF6/ NFATc1/miR-125a regulatory feedback loop. It suggests that regulation of miR-125a expression may be a potential strategy for ameliorating metabolic disease. - Highlights: • MiR-125a was significantly down-regulated in osteoclastogenesis of CD14+ PBMCs. • MiR-125a inhibited osteoclast differentiation by targeting TRAF6. • NFATc1 inhibited miR-125a transciption by binding to the promoter of miR-125a. • TRAF6/NFATc1 and miR-125a form a regulatory feedback loop in osteoclastogenesis.

  16. DOE - Office of Legacy Management -- Amex Specialty Metal Corp - MI 0-01

    Office of Legacy Management (LM)

    Amex Specialty Metal Corp - MI 0-01 FUSRAP Considered Sites Site: Amex Specialty Metal Corp (MI.0-01 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Coldwater , Michigan MI.0-01-1 Evaluation Year: 1987 MI.0-01-1 Site Operations: No indication that AMEX performed work for MED or AEC activities. Originally included on FUSRAP list due to fact that AMEX purchased milling equipment from a company that had done uranium milling.

  17. MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma

    SciTech Connect (OSTI)

    Xiong, Xinkui; Sun, Daoyi; Chai, Hao; Shan, Wengang; Yu, Yue; Pu, Liyong; Cheng, Feng

    2015-09-18

    The dysregulation of micro (mi)RNAs is associated with cancer development. The miRNA miR-145 is downregulated in intrahepatic cholangiocarcinoma (ICC); however, its precise role in tumor progression has not yet been elucidated. Novel (nua) kinase family (NUAK)1 functions as an oncogene in various cancers and is a putative target of miR-145 regulation. In this study, we investigated the regulation of NUAK1 by miR-145 in ICC. We found that miR-145 level was significantly decreased in ICC tissue and cell lines, which corresponded with an increase in NUAK1 expression. NUAK1 was found to be a direct target of miR-145 regulation. The overexpression of miR-145 in ICC cell lines inhibited proliferation, growth, and invasion by suppressing NUAK1 expression, which was associated with a decrease in Akt signaling and matrix metalloproteinase protein expression. Similar results were observed by inhibiting NUAK1 expression. These results demonstrate that miR-145 can prevent ICC progression by targeting NUAK1 and its downstream effectors, and can therefore be useful for clinical diagnosis and targeted therapy of ICC. - Highlights: • MiR-145 suppresses ICC proliferation and invasion abilities. • We demonstrated that miR-145 directly targets NUAK1 in ICC. • MiR-145 expression in ICC was associated with Akt signaling and MMPs expression.

  18. Neutron scattering study of spin ordering and stripe pinning in superconducting <mi>La>1.93<mi>Sr>0.07<mi>CuO>4

    SciTech Connect (OSTI)

    Jacobsen, H.; Zaliznyak, I. A.; Savici, A. T.; Winn, B. L.; Chang, S.; Hücker, M.; Gu, G. D.; Tranquada, J. M.

    2015-11-20

    The relationships among charge order, spin fluctuations, and superconductivity in underdoped cuprates remain controversial. We use neutron scattering techniques to study these phenomena in <mi>La>1.93<mi>Sr>0.07<mi>CuO>4 a superconductor with a transition temperature of Tc = 20 K. At T<< Tc, we find incommensurate spin fluctuations with a quasielastic energy spectrum and no sign of a gap within the energy range from 0.2 to 15 meV. A weak elastic magnetic component grows below ~ 10 K, consistent with results from local probes. Regarding the atomic lattice, we have discovered unexpectedly strong fluctuations of the CuO6 octahedra about Cu-O bonds, which are associated with inequivalent O sites within the CuO2 planes. Moreover, we observed a weak elastic (3 30) superlattice peak that implies a reduced lattice symmetry. The presence of inequivalent O sites rationalizes various pieces of evidence for charge stripe order in underdoped La2-xSrxCuO4. The coexistence of superconductivity with quasi-static spin-stripe order suggests the presence of intertwined orders; however, the rotation of the stripe orientation away from the Cu-O bonds might be connected with evidence for a finite gap at the nodal points of the superconducting gap function.

  19. Radiosensitizing Effects of Ectopic miR-101 on Non-Small-Cell Lung Cancer Cells Depend on the Endogenous miR-101 Level

    SciTech Connect (OSTI)

    Chen, Susie; Wang Hongyan; Ng, Wooi Loon; Curran, Walter J.; Wang Ya

    2011-12-01

    Purpose: Previously, we showed that ectopic miR-101 could sensitize human tumor cells to radiation by targeting ATM and DNA-PK catalytic subunit (DNA-PKcs) to inhibit DNA repair, as the endogenous miR-101 levels are low in tumors in general. However, the heterogeneity of human cancers may result in an exception. The purpose of this study was to test the hypothesis that a few tumor cell lines with a high level of endogenous miR-101 would prove less response to ectopic miR-101. Methods and Materials: Fourteeen non-small-cell lung cancer (NSCLC) cell lines and one immortalized non-malignant lung epithelial cell line (NL20) were used for comparing endogenous miR-101 levels by real-time reverse transcription-polymerase chain reaction. Based on the different miR-101 levels, four cell lines with different miR-101 levels were chosen for transfection with a green fluorescent protein-lentiviral plasmid encoding miR-101. The target protein levels were measured by using Western blotting. The radiosensitizing effects of ectopic miR-101 on these NSCLC cell lines were determined by a clonogenic assay and xenograft mouse model. Results: The endogenous miR-101 level was similar or lower in 13 NSCLC cell lines but was 11-fold higher in one cell line (H157) than in NL20 cells. Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299, H1975, and A549 cells, it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells. Similar results were observed in xenograft mice. Conclusions: A small number of NSCLC cell lines could have a high level of endogenous miR-101. The ectopic miR-101 was able to radiosensitize most NSCLC cells, except for the NSCLC cell lines that had a much higher endogenous miR-101 level. These results suggest that when we choose one miRNA as a therapeutic tool, the endogenous level of the miRNA in each tumor should be considered.

  20. ARM - Field Campaign - ARM Support for the Plains Elevated Convection...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    govCampaignsARM Support for the Plains Elevated Convection at Night Experiment: Doppler Lidar Operations Related Campaigns ARM Support for the Plains Elevated Convection at Night...

  1. Forest succession at elevated CO2

    SciTech Connect (OSTI)

    Clark, James S.; Schlesinger, William H.

    2002-02-01

    We tested hypotheses concerning the response of forest succession to elevated CO2 in the FACTS-1 site at the Duke Forest. We quantified growth and survival of naturally recruited seedlings, tree saplings, vines, and shrubs under ambient and elevated CO2. We planted seeds and seedlings to augment sample sites. We augmented CO2 treatments with estimates of shade tolerance and nutrient limitation while controlling for soil and light effects to place CO2 treatments within the context of natural variability at the site. Results are now being analyzed and used to parameterize forest models of CO2 response.

  2. Appending High-Resolution Elevation Data to GPS Speed Traces for Vehicle Energy Modeling and Simulation

    SciTech Connect (OSTI)

    Wood, E.; Burton, E.; Duran, A.; Gonder, J.

    2014-06-01

    Accurate and reliable global positioning system (GPS)-based vehicle use data are highly valuable for many transportation, analysis, and automotive considerations. Model-based design, real-world fuel economy analysis, and the growing field of autonomous and connected technologies (including predictive powertrain control and self-driving cars) all have a vested interest in high-fidelity estimation of powertrain loads and vehicle usage profiles. Unfortunately, road grade can be a difficult property to extract from GPS data with consistency. In this report, we present a methodology for appending high-resolution elevation data to GPS speed traces via a static digital elevation model. Anomalous data points in the digital elevation model are addressed during a filtration/smoothing routine, resulting in an elevation profile that can be used to calculate road grade. This process is evaluated against a large, commercially available height/slope dataset from the Navteq/Nokia/HERE Advanced Driver Assistance Systems product. Results will show good agreement with the Advanced Driver Assistance Systems data in the ability to estimate road grade between any two consecutive points in the contiguous United States.

  3. DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1

    SciTech Connect (OSTI)

    Lerner, Mikael; Harada, Masako; Loven, Jakob; Castro, Juan; Davis, Zadie; Oscier, David; Henriksson, Marie; Sangfelt, Olle; Grander, Dan; Corcoran, Martin M.

    2009-10-15

    The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. Despite their abundance in most cells the transcriptional regulation of miR-15a/16-1 remains unclear. Here we demonstrate that the putative tumor suppressor DLEU2 acts as a host gene of these microRNAs. Mature miR-15a/miR-16-1 are produced in a Drosha-dependent process from DLEU2 and binding of the Myc oncoprotein to two alterative DLEU2 promoters represses both the host gene transcript and levels of mature miR-15a/miR-16-1. In line with a functional role for DLEU2 in the expression of the microRNAs, the miR-15a/miR-16-1 locus is retained in four CLL cases that delete both promoters of this gene and expression analysis indicates that this leads to functional loss of mature miR-15a/16-1. We additionally show that DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. Together the data illuminate how inactivation of DLEU2 promotes cell proliferation and tumor progression through functional loss of miR-15a/miR-16-1.

  4. Genome-Wide Analysis of miRNA targets in Brachypodium and Biomass Energy Crops

    SciTech Connect (OSTI)

    Green, Pamela J.

    2015-08-11

    MicroRNAs (miRNAs) contribute to the control of numerous biological processes through the regulation of specific target mRNAs. Although the identities of these targets are essential to elucidate miRNA function, the targets are much more difficult to identify than the small RNAs themselves. Before this work, we pioneered the genome-wide identification of the targets of Arabidopsis miRNAs using an approach called PARE (German et al., Nature Biotech. 2008; Nature Protocols, 2009). Under this project, we applied PARE to Brachypodium distachyon (Brachypodium), a model plant in the Poaceae family, which includes the major food grain and bioenergy crops. Through in-depth global analysis and examination of specific examples, this research greatly expanded our knowledge of miRNAs and target RNAs of Brachypodium. New regulation in response to environmental stress or tissue type was found, and many new miRNAs were discovered. More than 260 targets of new and known miRNAs with PARE sequences at the precise sites of miRNA-guided cleavage were identified and characterized. Combining PARE data with the small RNA data also identified the miRNAs responsible for initiating approximately 500 phased loci, including one of the novel miRNAs. PARE analysis also revealed that differentially expressed miRNAs in the same family guide specific target RNA cleavage in a correspondingly tissue-preferential manner. The project included generation of small RNA and PARE resources for bioenergy crops, to facilitate ongoing discovery of conserved miRNA-target RNA regulation. By associating specific miRNA-target RNA pairs with known physiological functions, the research provides insights about gene regulation in different tissues and in response to environmental stress. This, and release of new PARE and small RNA data sets should contribute basic knowledge to enhance breeding and may suggest new strategies for improvement of biomass energy crops.

  5. miR-4295 promotes cell proliferation and invasion in anaplastic thyroid carcinoma via CDKN1A

    SciTech Connect (OSTI)

    Shao, Mingchen; Geng, Yiwei; Lu, Peng; Xi, Ying; Wei, Sidong; Wang, Liuxing; Fan, Qingxia; Ma, Wang

    2015-09-04

    MicroRNAs (miRNAs) play important roles in the pathogenesis of many types of cancers by negatively regulating gene expression at posttranscriptional level. However, the role of microRNAs in anaplastic thyroid carcinoma (ATC), has remained elusive. Here, we identified that miR-4295 promotes ATC cell proliferation by negatively regulates its target gene CDKN1A. In ATC cell lines, CCK-8 proliferation assay indicated that the cell proliferation was promoted by miR-4295, while miR-4295 inhibitor significantly inhibited the cell proliferation. Transwell assay showed that miR-4295 mimics significantly promoted the migration and invasion of ATC cells, whereas miR-4295 inhibitors significantly reduced cell migration and invasion. luciferase assays confirmed that miR-4295 directly bound to the 3'untranslated region of CDKN1A, and western blotting showed that miR-4295 suppressed the expression of CDKN1A at the protein levels. This study indicated that miR-4295 negatively regulates CDKN1A and promotes proliferation and invasion of ATC cell lines. Thus, miR-4295 may represent a potential therapeutic target for ATC intervention. - Highlights: • miR-4295 mimics promote the proliferation and invasion of ATC cells. • miR-4295 inhibitors inhibit the proliferation and invasion of ATC cells. • miR-4295 targets 3′UTR of CDKN1A in ATC cells. • miR-4295 negatively regulates CDKN1A in ATC cells.

  6. Microfluidic Molecular Assay Platform for the Detection of miRNAs...

    Office of Scientific and Technical Information (OSTI)

    Article: Microfluidic Molecular Assay Platform for the Detection of miRNAs, mRNAs, Proteins, and Post-translational Modifications at Single-cell Resolution. Citation Details...

  7. Groundwater protection for the NuMI project

    SciTech Connect (OSTI)

    Wehmann, A.; Smart, W.; Menary, S.; Hylen, J.; Childress, S.

    1997-10-01

    The physics requirements for the long base line neutrino oscillation experiment MINOS dictate that the NuMI beamline be located in the aquifer at Fermilab. A methodology is described for calculating the level of radioactivation of groundwater caused by operation of this beamline. A conceptual shielding design for the 750 meter long decay pipe is investigated which would reduce radioactivation of the groundwater to below government standards. More economical shielding designs to meet these requirements are being explored. Also, information on local geology, hydrogeology, government standards, and a glossary have been included.

  8. miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma

    SciTech Connect (OSTI)

    Zhai, Jian; Qu, Shuping; Li, Xiaowei; Zhong, Jiaming; Chen, Xiaoxia; Qu, Zengqiang; Wu, Dong

    2015-08-14

    Emerging evidence suggests that microRNAs (miRNAs) play important roles in regulating HCC development and progression; however, the mechanisms by which their specific functions and mechanisms remained to be further explored. miR-129 has been reported in gastric cancers, lung cancer and colon cancer. In this study, we disclosed a new tumor suppresser function of miR-129 in HCC. We also found the downregulation of miR-129 occurred in nearly 3/4 of the tumors examined (56/76) compared with adjacent nontumorous tissues, which was more importantly, correlated to the advanced stage and vascular invasion. We then demonstrated that miR-129 overexpression attenuated HCC cells proliferation and invasion, inducing apoptosis in vitro. Moreover, we used miR-129 antagonist and found that anti-miR-129 promoted HCC cells malignant phenotypes. Mechanistically, our further investigations revealed that miR-129 suppressed cell proliferation and invasion by targeting the 3’-untranslated region of PAK5, as well as miR-129 silencing up-regulated PAK5 expression. Moreover, miR-129 expression was inversely correlated with PAK5 expression in 76 cases of HCC samples. RNA interference of PAK5 attenuated anti-miR-129 mediated cell proliferation and invasion in HCC cells. Taken together, these results demonstrated that miR-129 suppressed tumorigenesis and progression by directly targeting PAK5, defining miR-129 as a potential treatment target for HCC. - Highlights: • Decreased of miR-129 is found in HCC and associated with advanced stage and metastasis. • miR-129 suppresses proliferation and invasion of HCC cells. • miR-129 directly targets the 3′ UTR of PAK5 and diminishes PAK5 expression. • PAK5 is involved in miR-129 mediated suppression functions.

  9. MiR-153 inhibits migration and invasion of human non-small-cell lung cancer by targeting ADAM19

    SciTech Connect (OSTI)

    Shan, Nianxi; Shen, Liangfang; Wang, Jun; He, Dan; Duan, Chaojun

    2015-01-02

    Highlights: • Decreased miR-153 and up-regulated ADAM19 are correlated with NSCLC pathology. • MiR-153 inhibits the proliferation and migration and invasion of NSCLC cells in vitro. • ADAM19 is a direct target of miR-153. • ADAM19 is involved in miR-153-suppressed migration and invasion of NSCLC cells. - Abstract: MiR-153 was reported to be dysregulated in some human cancers. However, the function and mechanism of miR-153 in lung cancer cells remains unknown. In this study, we investigated the role of miR-153 in human non-small-cell lung cancer (NSCLC). Using qRT-PCR, we demonstrated that miR-153 was significantly decreased in clinical NSCLC tissues and cell lines, and downregulation of miR-153 was significantly correlated with lymph node status. We further found that ectopic expression of miR-153 significantly inhibited the proliferation and migration and invasion of NSCLC cells in vitro, suggesting that miR-153 may be a novel tumor suppressor in NSCLC. Further integrated analysis revealed that ADAM19 is as a direct and functional target of miR-153. Luciferase reporter assay demonstrated that miR-153 directly targeted 3′UTR of ADAM19, and correlation analysis revealed an inverse correlation between miR-153 and ADAM19 mRNA levels in clinical NSCLC tissues. Knockdown of ADAM19 inhibited migration and invasion of NSCLC cells which was similar with effects of overexpression of miR-153, while overexpression of ADAM19 attenuated the function of miR-153 in NSCLC cells. Taken together, our results highlight the significance of miR-153 and ADAM19 in the development and progression of NSCLC.

  10. Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells

    SciTech Connect (OSTI)

    Li, Junxia; Shan, Fabo; Xiong, Gang; Wang, Ju-Ming; Wang, Wen-Lin; Xu, Xueqing; Bai, Yun

    2014-03-28

    Highlights: • MiR-146b promotes esophageal cancer cell proliferation. • MiR-146b inhibits esophageal cancer cell apoptosis. • C/EBPβ directly binds to miR-146b promoter conserved region. • MiR-146b is up-regulated by C/EBPβ LAP2 transcriptional activation. - Abstract: Recent clinical study indicated that up-regulation of miR-146b was associated with poor overall survival of patients in esophageal squamous cell carcinoma. However, the underlying mechanism of miR-146b dysregulation remains to be explored. Here we report that miR-146b promotes cell proliferation and inhibits cell apoptosis in esophageal cancer cell lines. Mechanismly, two C/EBPβ binding motifs are located in the miR-146b promoter conserved region. Among the three isoforms of C/EBPβ, C/EBPβ LAP2 positively regulated miR-146b expression and increases miR-146b levels in a dose-dependent manner through transcription activation of miR-146b gene. Together, these results suggest a miR-146b regulatory mechanism involving C/EBPβ, which may contribute to the up-regulation of miR-146b in esophageal squamous cell carcinoma.

  11. Fermilab Today | University Profiles

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    University Profiles Archive Subscribe | Contact Fermilab Today | Archive | Classifieds Search GO More than 2,000 scientists worldwide work with Fermilab. In the United States,...

  12. Profiling Your Application

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    sure to focus on only the main computation of your application (omitting initialization steps which may otherwise clutter the profiling results). Further, it may be valuable at...

  13. miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2

    SciTech Connect (OSTI)

    Fu, Jing; Xu, Xiaojie; Kang, Lei; Zhou, Liying; Wang, Shibin; Lu, Juming; Cheng, Long; Fan, Zhongyi; Yuan, Bin; Tian, Peirong; Zheng, Xiaofei; Yu, Chengze; Ye, Qinong; Lv, Zhaohui

    2014-03-07

    Highlights: • miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. • The miR-30a/EYA2 axis regulates breast cancer cell proliferation and migration. • The miR-30a/EYA2 axis modulates G1/S cell cycle progression. • The miR-30a/EYA2 axis is dysregulated in breast cancer patients. - Abstract: Eye absent (Eya) proteins are involved in cell fate determination in a broad spectrum of cells and tissues. Aberrant expression of Eya2 has been documented in a variety of cancers and correlates with clinical outcome. However, whether microRNAs (miRNAs) can regulate Eya2 expression remains unknown. Here, we show that miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. Overexpression of Eya2 in miR-30a-transfected breast cancer cells effectively rescued the inhibition of cell proliferation and migration caused by miR-30a. Knockdown of Eya2 by small-interfering RNA (siRNA) in breast cancer cells mimicked the effect induced by miR-30a and abolished the ability of miR-30a to regulate breast cancer cell proliferation and migration. The miR-30a/Eya2 axis could regulate G1/S cell cycle progression, accompanied by the modulation of expression of cell cycle-related proteins, including cyclin A, cyclin D1, cyclin E, and c-Myc. Moreover, miR-30a expression was downregulated in breast cancer patients, and negatively correlated with Eya2, which was upregulated in breast cancer patients. These data suggest that the miR-30a/Eya2 axis may play an important role in breast cancer development and progression and that miR-30a activation or Eya2 inhibition may be a useful strategy for cancer treatment.

  14. Gas-Alloy Interactions at Elevated Temperatures

    SciTech Connect (OSTI)

    Arroyave, Raymundo; Gao, Michael

    2012-11-07

    The understanding of the stability of metals and alloys against oxidation and other detrimental reactions, to the catalysis of important chemical reactions and the minimization of defects associated with processing and synthesis have one thing in common: At the most fundamental level, all these scientific/engineering problems involve interactions between metals and alloys (in the solid or liquid state) and gaseous atmospheres at elevated temperatures. In this special issue, we have collected a series of articles that illustrate the application of different theoretical, computational, and experimental techniques to investigate gas-alloy interactions.

  15. miR-182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma

    SciTech Connect (OSTI)

    Zhu, Hongling; Fang, Jin; Zhang, Jichen; Zhao, Zefei; Liu, Lianyong; Wang, Jingnan; Xi, Qian; Gu, Mingjun

    2014-07-18

    Highlights: miR-182 and CHL1 expression patterns are negatively correlated. CHL1 is a direct target of miR-182 in PTC cells. miR-182 suppression inhibits PTC cell growth and invasion. CHL1 is involved in miR-182-mediated cell behavior. - Abstract: In this study, we investigated the role and underlying mechanism of action of miR-182 in papillary thyroid carcinoma (PTC). Bioinformatics analysis revealed close homolog of LI (CHL1) as a potential target of miR-182. Upregulation of miR-182 was significantly correlated with CHL1 downregulation in human PTC tissues and cell lines. miR-182 suppressed the expression of CHL1 mRNA through direct targeting of the 3?-untranslated region (3?-UTR). Downregulation of miR-182 suppressed growth and invasion of PTC cells. Silencing of CHL1 counteracted the effects of miR-182 suppression, while its overexpression mimicked these effects. Our data collectively indicate that miR-182 in PTC promotes cell proliferation and invasion through direct suppression of CHL1, supporting the potential utility of miR-182 inhibition as a novel therapeutic strategy against PTC.

  16. Non-canonical microRNAs miR-320 and miR-702 promote proliferation in Dgcr8-deficient embryonic stem cells

    SciTech Connect (OSTI)

    Kim, Byeong-Moo; Choi, Michael Y.

    2012-09-21

    Highlights: Black-Right-Pointing-Pointer Embryonic stem cells (ESCs) lacking non-canonical miRNAs proliferate slower. Black-Right-Pointing-Pointer miR-320 and miR-702 are two non-canonical miRNAs expressed in ESCs. Black-Right-Pointing-Pointer miR-320 and miR-702 promote proliferation of Dgcr8-deficient ESCs. Black-Right-Pointing-Pointer miR-320 targets p57 and helps to release Dgcr8-deficient ESCs from G1 arrest. Black-Right-Pointing-Pointer miR-702 targets p21 and helps to release Dgcr8-deficient ESCs from G1 arrest. -- Abstract: MicroRNAs are known to contribute significantly to stem cell phenotype by post-transcriptionally regulating gene expression. Most of our knowledge of microRNAs comes from the study of canonical microRNAs that require two sequential cleavages by the Drosha/Dgcr8 heterodimer and Dicer to generate mature products. In contrast, non-canonical microRNAs bypass the cleavage by the Drosha/Dgcr8 heterodimer within the nucleus but still require cytoplasmic cleavage by Dicer. The function of non-canonical microRNAs in embryonic stem cells (ESCs) remains obscure. It has been hypothesized that non-canonical microRNAs have important roles in ESCs based upon the phenotypes of ESC lines that lack these specific classes of microRNAs; Dicer-deficient ESCs lacking both canonical and non-canonical microRNAs have much more severe proliferation defect than Dgcr8-deficient ESCs lacking only canonical microRNAs. Using these cell lines, we identified two non-canonical microRNAs, miR-320 and miR-702, that promote proliferation of Dgcr8-deficient ESCs by releasing them from G1 arrest. This is accomplished by targeting the 3 Prime -untranslated regions of the cell cycle inhibitors p57 and p21 and thereby inhibiting their expression. This is the first report of the crucial role of non-canonical microRNAs in ESCs.

  17. NuMI proton kicker extraction magnet termination resistor system

    SciTech Connect (OSTI)

    Reeves, S.R.; Jensen, C.C.; /Fermilab

    2005-05-01

    The temperature stability of the kicker magnet termination resistor assembly directly affects the field flatness and amplitude stability. Comprehensive thermal enhancements were made to the existing Main Injector resistor assembly design to satisfy NuMI performance specifications. Additionally, a fluid-processing system utilizing Fluorinert{reg_sign} FC-77 high-voltage dielectric was built to precisely control the setpoint temperature of the resistor assembly from 70 to 120F, required to maintain constant resistance during changing operational modes. The Fluorinert{reg_sign} must be continually processed to remove hazardous breakdown products caused by radiation exposure to prevent chemical attack of system components. Design details of the termination resistor assembly and Fluorinert{reg_sign} processing system are described. Early performance results will be presented.

  18. Downregulation of miRNA-30c and miR-203a is associated with hepatitis C virus core protein-induced epithelial–mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cells

    SciTech Connect (OSTI)

    Liu, Dongjing; Wu, Jilin; Liu, Meizhou; Yin, Hui; He, Jiantai; Zhang, Bo

    2015-09-04

    Hepatitis C virus (HCV) Core protein has been demonstrated to induce epithelial–mesenchymal transition (EMT) and is associated with cancer progression of hepatocellular carcinoma (HCC). However, how the Core protein regulates EMT is still unclear. In this study, HCV Core protein was overexpressed by an adenovirus. The protein levels of EMT markers were measured by Western blot. The xenograft animal model was established by inoculation of HepG2 cells. Results showed that ectopic expression of HCV core protein induced EMT in L02 hepatocytes and HepG2 tumor cells by upregulating vimentin, Sanl1, and Snal2 expression and downregulating E-cadherin expression. Moreover, Core protein downregulated miR-30c and miR-203a levels in L02 and HepG2 cells, but artificial expression of miR-30c and miR-203a reversed Core protein-induced EMT. Further analysis showed that ectopic expression of HCV core protein stimulated cell proliferation, inhibited apoptosis, and increased cell migration, whereas artificial expression of miR-30c and miR-203a significantly reversed the role of Core protein in these cell functions in L02 and HepG2 cells. In the HepG2 xenograft tumor models, artificial expression of miR-30c and miR-203a inhibited EMT and tumor growth. Moreover, L02 cells overexpressing Core protein can form tumors in nude mice. In HCC patients, HCV infection significantly shortened patients' survival time, and loss of miR-30c and miR-203 expression correlated with poor survival. In conclusion, HCV core protein downregulates miR-30c and miR-203a expression, which results in activation of EMT in normal hepatocytes and HCC tumor cells. The Core protein-activated-EMT is involved in the carcinogenesis and progression of HCC. Loss of miR-30c and miR-203a expression is a marker for the poor prognosis of HCC. - Highlights: • HCV core protein downregulates miR-30c and miR-203a expression. • Downregulation of miR-30c and miR-203a activates EMT. • Activated-EMT is involved in the

  19. miR-128 and its target genes in tumorigenesis and metastasis

    SciTech Connect (OSTI)

    Li, Molin, E-mail: molin_li@hotmail.com [Dalian Medical University, Dalian 116044 (China); Fu, Weiming [Center for Food Safety and Environmental Technology, Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou 511458 (China); Wo, Lulu; Shu, Xiaohong [Dalian Medical University, Dalian 116044 (China); Liu, Fang [The second affiliated hospital of Dalian Medical University, Dalian 116023 (China); Li, Chuangang, E-mail: li_chuangang@sina.com [The second affiliated hospital of Dalian Medical University, Dalian 116023 (China)

    2013-12-10

    MicroRNAs (miRNAs) are a class of endogenous, non-coding, 1824 nucleotide length single-strand RNAs that could modulate gene expression at post-transcriptional level. Previous studies have shown that miR-128 enriched in the brain plays an important role in the development of nervous system and the maintenance of normal physical functions. Aberrant expression of miR-128 has been detected in many types of human tumors and its validated target genes are involved in cancer-related biological processes such as cell proliferation, differentiation and apoptosis. In this review, we will summarize the roles of miR-128 and its target genes in tumorigenesis and metastasis. - Highlights: Aberrant expression of miR-128 can be observed in many kinds of malignant tumors. The molecular mechanisms regulating miR-128 expression are elucidated. Roles of miR-128 and its target genes in tumorigenesis and metastasis are summarized.

  20. Elevated temperature forming method and preheater apparatus

    DOE Patents [OSTI]

    Krajewski, Paul E; Hammar, Richard Harry; Singh, Jugraj; Cedar, Dennis; Friedman, Peter A; Luo, Yingbing

    2013-06-11

    An elevated temperature forming system in which a sheet metal workpiece is provided in a first stage position of a multi-stage pre-heater, is heated to a first stage temperature lower than a desired pre-heat temperature, is moved to a final stage position where it is heated to a desired final stage temperature, is transferred to a forming press, and is formed by the forming press. The preheater includes upper and lower platens that transfer heat into workpieces disposed between the platens. A shim spaces the upper platen from the lower platen by a distance greater than a thickness of the workpieces to be heated by the platens and less than a distance at which the upper platen would require an undesirably high input of energy to effectively heat the workpiece without being pressed into contact with the workpiece.

  1. Traction sheave elevator, hoisting unit and machine space

    DOE Patents [OSTI]

    Hakala, Harri; Mustalahti, Jorma; Aulanko, Esko

    2000-01-01

    Traction sheave elevator consisting of an elevator car moving along elevator guide rails, a counterweight moving along counterweight guide rails, a set of hoisting ropes (3) on which the elevator car and counterweight are suspended, and a drive machine unit (6) driving a traction sheave (7) acting on the hoisting ropes (3) and placed in the elevator shaft. The drive machine unit (6) is of a flat construction. A wall of the elevator shaft is provided with a machine space with its open side facing towards the shaft, the essential parts of the drive machine unit (6) being placed in the space. The hoisting unit (9) of the traction sheave elevator consists of a substantially discoidal drive machine unit (6) and an instrument panel (8) mounted on the frame (20) of the hoisting unit.

  2. Overexpression of miR-206 suppresses glycolysis, proliferation and migration in breast cancer cells via PFKFB3 targeting

    SciTech Connect (OSTI)

    Ge, Xin; Lyu, Pengwei; Cao, Zhang; Li, Jingruo; Guo, Guangcheng; Xia, Wanjun; Gu, Yuanting

    2015-08-07

    miRNAs, sorting as non-coding RNAs, are differentially expressed in breast tumor and act as tumor promoters or suppressors. miR-206 could suppress the progression of breast cancer, the mechanism of which remains unclear. The study here was aimed to investigate the effect of miR-206 on human breast cancers. We found that miR-206 was down-regulated while one of its predicted targets, 6-Phosphofructo-2-kinase (PFKFB3) was up-regulated in human breast carcinomas. 17β-estradiol dose-dependently decreased miR-206 expression as well as enhanced PFKFB3 mRNA and protein expression in estrogen receptor α (ERα) positive breast cancer cells. Furthermore, we identified that miR-206 directly interacted with 3′-untranslated region (UTR) of PFKFB3 mRNA. miR-206 modulated PFKFB3 expression in MCF-7, T47D and SUM159 cells, which was influenced by 17β-estradiol depending on ERα expression. In addition, miR-206 overexpression impeded fructose-2,6-bisphosphate (F2,6BP) production, diminished lactate generation and reduced cell proliferation and migration in breast cancer cells. In conclusion, our study demonstrated that miR-206 regulated PFKFB3 expression in breast cancer cells, thereby stunting glycolysis, cell proliferation and migration. - Highlights: • miR-206 was down-regulated and PFKFB3 was up-regulated in human breast carcinomas. • 17β-estradiol regulated miR-206 and PFKFB3 expression in ERα+ cancer cells. • miR-206directly interacted with 3′-UTR of PFKFB3 mRNA. • miR-206 fructose-2,6-bisphosphate (F2,6BP) impeded production and lactate generation. • miR-206 reduced cell proliferation and migration in breast cancer cells.

  3. Project Profile: Novel Thermal Storage Technologies for Concentrating Solar

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Power Generation | Department of Energy Storage Technologies for Concentrating Solar Power Generation Project Profile: Novel Thermal Storage Technologies for Concentrating Solar Power Generation Lehigh logo Lehigh University, under the Thermal Storage FOA, is working to establish the technical feasibility of using phase change materials (PCM) at elevated temperatures and to acquire engineering results that will lead to the demonstration of large-scale thermal storage systems. Approach A

  4. AMENDMENT OF SOLICITATION/MODIFICATlON OF CONTRACT MI54 I See...

    National Nuclear Security Administration (NNSA)

    MI54 I See Block 16C I REQ. NO. Babcock & Wilcox Technical Services Pantex, LLC PO Box 30020 Amarillo, TX 79120 2. AMENDMENTIMODIFICATION NO. 1 3. EFFECTIVE DATE 1 4. ...

  5. File:USDA-CE-Production-GIFmaps-MI.pdf | Open Energy Information

    Open Energy Info (EERE)

    MI.pdf Jump to: navigation, search File File history File usage Michigan Ethanol Plant Locations Size of this preview: 463 599 pixels. Other resolution: 464 600 pixels. Full...

  6. Climate Action Champions: Sault Ste. Marie Tribe of Chippewa Indians, MI |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Sault Ste. Marie Tribe of Chippewa Indians, MI Climate Action Champions: Sault Ste. Marie Tribe of Chippewa Indians, MI The Sault Ste. Marie Tribe of Chippewa Indians is a 44,000-strong federally recognized Indian tribe that is an economic, social and cultural force in its community across the eastern Upper Peninsula counties of Chippewa, Luce, Mackinac, Schoolcraft, Alger, Delta and Marquette, with housing and tribal centers, casinos, and other enterprises that employ

  7. Country profile: Hungary

    SciTech Connect (OSTI)

    Not Available

    1991-09-01

    Country Profile: Hungary has been prepared as a background document for use by US Government agencies and US businesses interested in becoming involved with the new democracies of Eastern Europe as they pursue sustainable economic development. The focus of the Profile is on energy and highlights information on Hungary's energy supply, demand, and utilization. It identifies patterns of energy usage in the important economic sectors, especially industry, and provides a preliminary assessment for opportunities to improve efficiencies in energy production, distribution and use by introducing more efficient technologies. The use of more efficient technologies would have the added benefit of reducing the environmental impact which, although is not the focus of the report, is an issue that effects energy choices. The Profile also presents considerable economic information, primarily in the context of how economic restructuring may affect energy supply, demand, and the introduction of more efficient technologies.

  8. Country profile: Hungary

    SciTech Connect (OSTI)

    Not Available

    1991-09-01

    Country Profile: Hungary has been prepared as a background document for use by US Government agencies and US businesses interested in becoming involved with the new democracies of Eastern Europe as they pursue sustainable economic development. The focus of the Profile is on energy and highlights information on Hungary`s energy supply, demand, and utilization. It identifies patterns of energy usage in the important economic sectors, especially industry, and provides a preliminary assessment for opportunities to improve efficiencies in energy production, distribution and use by introducing more efficient technologies. The use of more efficient technologies would have the added benefit of reducing the environmental impact which, although is not the focus of the report, is an issue that effects energy choices. The Profile also presents considerable economic information, primarily in the context of how economic restructuring may affect energy supply, demand, and the introduction of more efficient technologies.

  9. Detonation Wave Profile

    SciTech Connect (OSTI)

    Menikoff, Ralph

    2015-12-14

    The Zel’dovich-von Neumann-Doering (ZND) profile of a detonation wave is derived. Two basic assumptions are required: i. An equation of state (EOS) for a partly burned explosive; P(V, e, λ). ii. A burn rate for the reaction progress variable; d/dt λ = R(V, e, λ). For a steady planar detonation wave the reactive flow PDEs can be reduced to ODEs. The detonation wave profile can be determined from an ODE plus algebraic equations for points on the partly burned detonation loci with a specified wave speed. Furthermore, for the CJ detonation speed the end of the reaction zone is sonic. A solution to the reactive flow equations can be constructed with a rarefaction wave following the detonation wave profile. This corresponds to an underdriven detonation wave, and the rarefaction is know as a Taylor wave.

  10. Strontium sorption on hematite at elevated temperatures

    SciTech Connect (OSTI)

    Karasyova, O.N.; Ivanova, L.I.; Lakshtanov, L.Z.; Loevgren, L.

    1999-12-15

    Acid-base reactions and surface complexation of Sr(II) at the hematite/water interface have been studied by means of potentiometric titrations at three different temperatures: 25, 50, and 75 C. Equilibrium measurements were performed in 0.1 M NaCl. In the evaluation of equilibrium models for the acid-base reactions and complexation reactions in the three-component system H{sup +} -({triple{underscore}bond}FeOH)-Sr{sup 2+}, the constant capacitance model was applied. During the titrations with Sr, aliquots of the suspension were sampled at in several points. The aqueous concentrations of Sr were analyzed by atomic absorption spectrometry. Treatment of data included tests for formation of both inner-sphere and outer-sphere complexes of different stoichiometric composition. The proposed equilibrium model consists of the following surface complexes of inner sphere type: {triple{underscore}bond}FeOHSr{sup 2+} and {triple{underscore}bond}FeOSrOH. Besides the stability constants for the surface complexes, the thermodynamic parameters {Delta}H and {Delta}S were evaluated. The combined effect of a decrease in pH{sub pzc} with increasing temperature and positive enthalpies of surface complex formation favors adsorption of Sr at elevated temperatures.

  11. Low profile thermite igniter

    DOE Patents [OSTI]

    Halcomb, Danny L.; Mohler, Jonathan H.

    1991-03-05

    A thermite igniter/heat source comprising a housing, high-density thermite, and low-density thermite. The housing has a relatively low profile and can focus energy by means of a torch-like ejection of hot reaction products and is externally ignitable.

  12. Profile for Gautam Gupta

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Gautam Gupta Profile Pages View homepages for scientists and researchers. Explore potential collaborations and project opportunities. Search the extensive range of capabilities by keyword to quickly find who and what you are looking for. submit Gautam Gupta Gautam Gupta Email Phone (505) 606-0852 Capabilities Biosciences Biomaterials Chemical Science Biological chemistry Inorganic chemistry Organic chemistry Physical chemistry Energetic materials Mass spectrometers Materials chemistry

  13. Profile for Hisato Yamaguchi

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hisato Yamaguchi Profile Pages View homepages for scientists and researchers. Explore potential collaborations and project opportunities. Search the extensive range of capabilities by keyword to quickly find who and what you are looking for. submit Hisato Yamaguchi Hisato Yamaguchi Email Phone (505) 664-0382 Capabilities Chemical Science Energetic materials Separation technologies Materials chemistry Carbon nanotubes Nanostructured quantum confined materials Materials Materials by design

  14. Importance of Elevation and Temperature Inversions for the Interpretat...

    Open Energy Info (EERE)

    with elevation, on which temperature inversions appear superimposed as opposite trends. Such inversions are common and they should be taken into account, along with the...

  15. ARM - Field Campaign - ARM Support for the Plains Elevated Convection...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Convection at Night Experiment: Doppler Lidar Operations 2015.06.01, Turner, SGP Comments? ... Lead Scientist : David Turner For data sets, see below. Abstract The Plains Elevated ...

  16. Chemical Impact of Elevated CO2on Geothermal Energy Production...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    analyzing the geochemistry of existing geothermal fields with elevated natural CO2; measuring realistic rock-water rates for geothermal systems using laboratory and field-based ...

  17. Elevated Carbon Dioxide Suppresses Dominant Plant Species in...

    Office of Science (SC) Website

    depend on interannual variation in precipitation and (2) the effects of elevated carbon dioxide are not limited to water saving because they differ from those of irrigation. ...

  18. miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1

    SciTech Connect (OSTI)

    Xu, Zhengyu; Wang, Tao

    2014-06-27

    Highlights: • miR-214 is upregulated in human OS tissues and inversely correlated with LZTS1 expression. • miR-214 directly targets LZTS1 by binding to its 3′-UTR. • miR-214 promotes OS cell proliferation, invasion and tumor growth. • Overexpression of LZTS1 reverses miR-214-induced proliferation and invasion of OS cells. - Abstract: Previous studies have shown that miR-214 functions either as an oncogene or a tumor suppressor in various human cancer types. The role of this microRNA in osteosarcoma (OS) is presently unclear. Here, we demonstrated that miR-214 is frequently upregulated in OS specimens, compared with noncancerous bone tissues. Bioinformatics analysis further revealed leucine zipper, putative tumor suppressor 1 (LZTS1) as a potential target of miR-214. Expression patterns of miR-214 were inversely correlated with those of LZTS1 mRNA and protein in OS tissues. Data from reporter assays showed that miR-214 directly binds to the 3′-untranslated region (3′-UTR) of LZTS1 mRNA and suppresses expression at both transcriptional and translational levels. In functional assays, miR-214 promoted OS cell proliferation, invasion and tumor growth in nude mice, which could be reversed by overexpression of LZTS1. Taken together, our data provide compelling evidence that miR-214 functions as an onco-miRNA in OS, and its oncogenic effects are mediated chiefly through downregulation of LZTS1.

  19. miR-421 induces cell proliferation and apoptosis resistance in human nasopharyngeal carcinoma via downregulation of FOXO4

    SciTech Connect (OSTI)

    Chen, Liang; Department of Otolaryngology, Guangzhou General Hospital of PLA Guangzhou Command, Guangzhou 510010 ; Tang, Yanping; Wang, Jian; Yan, Zhongjie; Xu, Ruxiang

    2013-06-14

    Highlights: •miR-421 is upregulated in nasopharyngeal carcinoma. •miR-421 induces cell proliferation and apoptosis resistance. •FOXO4 is a direct and functional target of miR-421. -- Abstract: microRNAs have been demonstrated to play important roles in cancer development and progression. Hence, identifying functional microRNAs and better understanding of the underlying molecular mechanisms would provide new clues for the development of targeted cancer therapies. Herein, we reported that a microRNA, miR-421 played an oncogenic role in nasopharyngeal carcinoma. Upregulation of miR-421 induced, whereas inhibition of miR-421 repressed cell proliferation and apoptosis resistance. Furthermore, we found that upregulation of miR-421 inhibited forkhead box protein O4 (FOXO4) signaling pathway following downregulation of p21, p27, Bim and FASL expression by directly targeting FOXO4 3′UTR. Additionally, we demonstrated that FOXO4 expression is critical for miR-421-induced cell growth and apoptosis resistance. Taken together, our findings not only suggest that miR-421 promotes nasopharyngeal carcinoma cell proliferation and anti-apoptosis, but also uncover a novel regulatory mechanism for inactivation of FOXO4 in nasopharyngeal carcinoma.

  20. Temperature profile detector

    DOE Patents [OSTI]

    Tokarz, R.D.

    1983-10-11

    Disclosed is a temperature profile detector shown as a tubular enclosure surrounding an elongated electrical conductor having a plurality of meltable conductive segments surrounding it. Duplicative meltable segments are spaced apart from one another along the length of the enclosure. Electrical insulators surround these elements to confine molten material from the segments in bridging contact between the conductor and a second electrical conductor, which might be the confining tube. The location and rate of growth of the resulting short circuits between the two conductors can be monitored by measuring changes in electrical resistance between terminals at both ends of the two conductors. Additional conductors and separate sets of meltable segments operational at differing temperatures can be monitored simultaneously for measuring different temperature profiles. 8 figs.

  1. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Alabama Nuclear Profile 2010 Alabama profile Alabama total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 5,043 15.6 37,941 24.9 Coal 11,441 35.3 63,050 41.4 Hydro and Pumped Storage 3,272 10.1 8,704 5.7 Natural Gas 11,936 36.8 39,235 25.8 Other1 100 0.3 643 0.4 Other Renewable1 583 1.8 2,377 1.6 Petroleum 43 0.1 200

  2. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Arkansas Nuclear Profile 2010 Arkansas profile Arkansas total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State ttal (percent) Nuclear 1,835 11.5 15,023 24.6 Coal 4,535 28.4 28,152 46.2 Hydro and Pumped Storage 1,369 8.6 3,658 6.0 Natural Gas 7,894 49.4 12,469 20.4 Other 1 - - 28 * Other Renewable1 326 2.0 1,624 2.7 Petroleum 22 0.1 45 0.1 Total

  3. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    California Nuclear Profile 2010 California profile California total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 4,390 6.5 32,201 15.8 Coal 374 0.6 2,100 1.0 Hydro and Pumped Storage 13,954 20.7 33,260 16.3 Natural Gas 41,370 61.4 107,522 52.7 Other 1 220 0.3 2,534 1.2 Other Renewable1 6,319 9.4 25,450 12.5 Petroleum

  4. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Florida Nuclear Profile 2010 Florida profile Florida total electric power industry, summer capacity and net generation, by energy source, 2010 Primary Energy Source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 3,924 6.6 23,936 10.4 Coal 9,975 16.9 59,897 26.1 Hydro and Pumped Storage 55 0.1 177 0.1 Natural Gas 31,563 53.4 128,634 56.1 Other1 544 0.9 2,842 1.2 Other Renewable1 1,053 1.8 4,487 2.0 Petroleum 12,033 20.3

  5. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Georgia Nuclear Profile 2010 Georgia profile Georgia total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 4,061 11.1 33,512 24.6 Coal 13,230 36.1 73,298 54.0 Hydro and Pumped Storage 3,851 10.5 3,044 2.7 Natural Gas 12,668 34.6 23,884 15.9 Other 1 - - 18 * Other Renewable1 637 1.7 3,181 2.2 Petroleum 2,189 6.0 641 0.5

  6. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Illinois Nuclear Profile 2010 Illinois profile Illinois total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 11,441 25.9 96,190 47.8 Coal 15,551 35.2 93,611 46.5 Hydro and Pumped Storage 34 0.1 119 0.1 Natural Gas 13,771 31.2 5,724 2.8 Other 1 145 0.3 461 0.2 Other Renewable1 2,078 4.7 5,138 2.6 Petroleum 1,106 2.5 110

  7. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Iowa Nuclear Profile 2010 Iowa profile Iowa total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 601 4.1 4,451 7.7 Coal 6,956 47.7 41,283 71.8 Hydro and Pumped Storage 144 1.0 948 1.6 Natural Gas 2,299 15.8 1,312 2.3 Other Renewable1 3,584 24.6 9,360 16.3 Petroleum 1,007 6.9 154 .0.3 Total 14,592 100.0 57,509 100

  8. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Louisiana Nuclear Profile 2010 Louisiana profile Louisiana total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (nw) Share of State total (percent) Net generation (thousand nwh) Share of State total (percent) Nuclear 2,142 8.0 18,639 18.1 Coal 3,417 12.8 23,924 23.3 Hydro and Pumped Storage 192 0.7 1,109 1.1 Natural Gas 19,574 73.2 51,344 49.9 Other 1 213 0.8 2,120 2.1 Other Renewable1 325 1.2 2,468 2.4 Petroleum 881 3.3

  9. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Maryland Nuclear Profile 2010 Maryland profile Maryland total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (Percent) Nuclear 1,705 13.6 13,994 32.1 Coal 4,886 39.0 23,668 54.3 Hydro and Pumped Storage 590 4.7 1,667 3.8 Natural Gas 2,041 16.3 2,897 6.6 Other 1 152 1.2 485 1.1 Other Renewable1 209 1.7 574 1.3 Petroleum 2,933 23.4 322

  10. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Massachusetts Nuclear Profile 2010 Massachusetts profile Massachusetts total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 685 5.0 5,918 13.8 Coal 1,669 12.2 8,306 19.4 Hydro and Pumped Storage 1,942 14.2 659 1.5 Natural Gas 6,063 44.3 25,582 59.8 Other 1 3 * 771 1.8 Other Renewable1 304 2.2 1,274 3.0 Petroleum 3,031

  11. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Michigan Nuclear Profile 2010 Michigan profile Michigan total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 3,947 13.2 29,625 26.6 Coal 11,531 38.7 65,604 58.8 Hydro and Pumped Storage 2,109 7.1 228 0.2 Natural Gas 11,033 37.0 12,249 11.0 Other 1 - - 631 0.6 Other Renewable1 571 1.9 2,832 2.5 Petroleum 640 2.1 382 0.3

  12. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Minnesota Nuclear Profile 2010 Minnesota profile Minnesota total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 1,549 10.8 13,478 25.1 Coal 4,789 32.5 28,083 52.3 Hydro and Pumped Storage 193 1.3 840 1.6 Natural Gas 4,936 33.5 4,341 8.1 Other 1 13 0.1 258 0.5 Other Renewable1 2,395 16.3 6,640 12.4 Petroleum 795 5.4 31

  13. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Nebraska Nuclear Profile 2010 Nebraska profile Nebraska total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 1,245 15.8 11,054 30.2 Coal 3,932 50.0 23,368 63.8 Hydro and Pumped Storage 278 3.5 1,314 3.6 Natural Gas 1,864 23.5 375 1.0 Other Renewable1 165 2.1 493 1.3 Petroleum 387 4.9 31 0.1 Total 7,857 100.0 36,630

  14. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Hampshire Nuclear Profile 2010 New Hampshire profile New Hampshire total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 1,247 29.8 10,910 49.2 Coal 546 13.1 3,083 13.9 Hydro and Pumped Storage 489 11.7 1,478 6.7 Natural Gas 1,215 29.1 5,365 24.2 Other 1 - - 57 0.3 Other Renewable1 182 4.4 1,232 5.6 Petroleum 501 12.0

  15. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Jersey Nuclear Profile 2010 New Jersey profile New Jersey total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 4,108 22.3 32,771 49.9 Coal 2,036 11.1 6,418 9.8 Hydro and Pumped Storage 404 2.2 -176 -0.3 Natural Gas 10,244 55.6 24,902 37.9 Other 1 56 0.3 682 1.0 Other Renewable1 226 1.2 850 1.3 Petroleum 1,351 7.3 235

  16. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    York Nuclear Profile 2010 New York profile New York total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 5,271 13.4 41,870 30.6 Coal 2,781 7.1 13,583 9.9 Hydro and Pumped Storage 5,714 14.5 24,942 18.2 Natural Gas 17,407 44.2 48,916 35.7 Other 1 45 0.1 832 0.6 Other Renewable1 1,719 4.4 4,815 3.5 Petroleum 6,421 16.3

  17. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    North Carolina Nuclear Profile 2010 North Carolina profile North Carolina total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 4,958 17.9 40,740 31.7 Coal 12,766 46.1 71,951 55.9 Hydro and Pumped Storage 2,042 7.4 4,757 3.7 Natural Gas 6,742 24.4 8,447 6.6 Other 1 50 0.2 407 0.3 Other Renewable1 543 2.0 2,083 1.6

  18. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Ohio Nuclear Profile 2010 Ohio profile Ohio total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 2,134 6.5 15,805 11.0 Coal 21,360 64.6 117,828 82.1 Hydro and Pumped Storage 101 0.3 429 0.3 Natural Gas 8,203 24.8 7,128 5.0 Other 1 123 0.4 266 0.2 Other Renewable1 130 0.4 700 0.5 Petroleum 1,019 3.1 1,442 1.0 Total

  19. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Pennsylvania Nuclear Profile 2010 Pennsylvania profile Pennsylvania total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 9,540 20.9 77,828 33.9 Coal 18,481 40.6 110,369 48.0 Hydro and Pumped Storage 2,268 5.0 1,624 0.7 Natural Gas 9,415 20.7 33,718 14.7 Other 1 100 0.2 1,396 0.6 Other Renewable1 1,237 2.7 4,245 1.8

  20. Aerosol Extinction Profiles

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Thermodynamic Responses to Uncertainty in Aerosol Extinction Profiles For original submission and image(s), see ARM Research Highlights http://www.arm.gov/science/highlights/ Research Highlight Aerosol radiative effects are of great importance for climate simulations over South Asia. For quantifying aerosol direct radiative effect, aerosol optical depth (AOD) and single scattering albedo (SSA) are often compared with observations. These comparisons have revealed large AOD underestimation and

  1. Compare Gene Profiles

    SciTech Connect (OSTI)

    2014-05-31

    Compare Gene Profiles (CGP) performs pairwise gene content comparisons among a relatively large set of related bacterial genomes. CGP performs pairwise BLAST among gene calls from a set of input genome and associated annotation files, and combines the results to generate lists of common genes, unique genes, homologs, and genes from each genome that differ substantially in length from corresponding genes in the other genomes. CGP is implemented in Python and runs in a Linux environment in serial or parallel mode.

  2. State Nuclear Profiles 2010

    U.S. Energy Information Administration (EIA) Indexed Site

    Nuclear Profiles 2010 April 2012 Independent Statistics & Analysis www.eia.gov U.S. Department of Energy Washington, DC 20585 This report was prepared by the U.S. Energy Information Administration (EIA), the statistical and analytical agency within the U.S. Department of Energy. By law, EIA's data, analyses, and forecasts are independent of approval by any other officer or employee of the United States Government. The views in this report therefore should not be construed as representing

  3. LANL Data Profile

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Data Profile 2012-2013 Total: 10,407 Quick Facts FY2013 Operating Budget ..... $1.95 billion Operating costs 54% NNSA Weapons Programs 12% Work for other agencies 10% Nonproliferation programs 9% Environmental management 6% Safeguards and security 5% DOE Office of Science 4% Energy and related programs Workforce Demographics Average Age: 46 67% male, 33% female 45% ethnic minorities 67% university degrees -28% undergraduate degrees -17% graduate degrees -22% PhD degrees Capital/Construction

  4. Surface profiling interferometer

    DOE Patents [OSTI]

    Takacs, Peter Z.; Qian, Shi-Nan

    1989-01-01

    The design of a long-trace surface profiler for the non-contact measurement of surface profile, slope error and curvature on cylindrical synchrotron radiation (SR) mirrors. The optical system is based upon the concept of a pencil-beam interferometer with an inherent large depth-of-field. The key feature of the optical system is the zero-path-difference beam splitter, which separates the laser beam into two colinear, variable-separation probe beams. A linear array detector is used to record the interference fringe in the image, and analysis of the fringe location as a function of scan position allows one to reconstruct the surface profile. The optical head is mounted on an air bearing slide with the capability to measure long aspheric optics, typical of those encountered in SR applications. A novel feature of the optical system is the use of a transverse "outrigger" beam which provides information on the relative alignment of the scan axis to the cylinder optic symmetry axis.

  5. Stoichiometry dependence of potential screening at <mi mathvariant="normal">Lami> ( 1 - <mi>δ> ) <mi mathvariant="normal">Almi> ( 1 + <mi>δ> ) <mi mathvariant="normal">Omi> 3 / <mi mathvariant="normal">SrTiOmi> 3 interfaces

    SciTech Connect (OSTI)

    Weiland, Conan; Sterbinsky, George E.; Rumaiz, Abdul K.; Hellberg, C. Stephen; Woicik, Joseph C.; Zhu, Shaobo; Schlom, Darrell G.

    2015-04-03

    Hard x-ray photoelectron spectroscopy (HAXPES) and variable kinetic energy x-ray photoelectron spectroscopy (VKE-XPS) analyses have been performed on ten-unit-cell-thick La(1-δ)Al(1+δ)O₃ films, with La:Al ratios of 1.1, 1.0, and 0.9, deposited on SrTiO₃. Only Al-rich films are known to have a conductive interface. VKE-XPS, coupled with maximum entropy analysis, shows significant differences in the compositional depth profile among the Al-rich, La-rich, and stoichiometric films: significant La enrichment at the interface is observed in the La-rich and stoichiometric films, while the Al-rich film shows little to no intermixing. Additionally, the La-rich and stoichiometric films show a high concentration of Al at the surface, which is not observed in the Al-rich film. HAXPES valence band (VB) analysis shows a broadening of the VB for the Al-rich sample relative to the stoichiometric and La-rich samples. This broadening is consistent with an electric field across the Al-rich film. These results are consistent with a defect-driven electronic reconstruction.

  6. miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression

    SciTech Connect (OSTI)

    Yu, Peng; Wu, Dingguo; You, Yu; Sun, Jing; Lu, Lele; Tan, Jiaxing; Bie, Ping

    2015-08-15

    MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test results revealed that miR-208-3p down-regulation inhibited HCC tumorigenesis in Hep3B cells. Moreover, ARID2 was possibly a downstream element of transforming growth factor beta1 (TGFβ1)/miR-208-3p/ARID2 regulatory pathway. These findings suggested that miR-208-3p up-regulation is associated with HCC cell progression and may provide a new target for liver cancer treatment. - Highlights: • miR-208-3p was highly expressed and directly repressed the expression of ARID2 in HCC. • miR-208-3p contributed to HCC cell progression both in vitro and in vivo. • Over-expression of ARID2 inhibited the HCC cell proliferation and invasion. • Restoration of ARID2 partly reversed the the effect of miR-208-3p down-regulation on HCC cells. • Newly regulatory pathway: miR-208-3p mediated the repression of ARID2 by TGFβ1 in HCC cells.

  7. Curcumin inhibits oral squamous cell carcinoma SCC-9 cells proliferation by regulating miR-9 expression

    SciTech Connect (OSTI)

    Xiao, Can; Wang, Lili; Zhu, Lifang; Zhang, Chenping; Zhou, Jianhua

    2014-11-28

    Highlights: • miR-9 expression level was significantly decreased in OSCC tissues. • Curcumin significantly inhibited SCC-9 cells proliferation. • miR-9 mediates the inhibition of SCC-9 proliferation by curcumin. • Curcumin suppresses Wnt/β-catenin signaling in SCC-9 cells. • miR-9 mediates the suppression of Wnt/β-catenin signaling by curcumin. - Abstract: Curcumin, a phytochemical derived from the rhizome of Curcuma longa, has shown anticancer effects against a variety of tumors. In the present study, we investigated the effects of curcumin on the miR-9 expression in oral squamous cell carcinoma (OSCC) and explored the potential relationships between miR-9 and Wnt/β-catenin pathway in curcumin-mediated OSCC inhibition in vitro. As the results shown, the expression levels of miR-9 were significantly lower in clinical OSCC specimens than those in the adjacent non-tumor tissues. Furthermore, our results indicated that curcumin inhibited OSCC cells (SCC-9 cells) proliferation through up-regulating miR-9 expression, and suppressing Wnt/β-catenin signaling by increasing the expression levels of the GSK-3β, phosphorylated GSK-3β and β-catenin, and decreasing the cyclin D1 level. Additionally, the up-regulation of miR-9 by curcumin in SCC-9 cells was significantly inhibited by delivering anti-miR-9 but not control oligonucleotides. Downregulation of miR-9 by anti-miR-9 not only attenuated the growth-suppressive effects of curcumin on SCC-9 cells, but also re-activated Wnt/β-catenin signaling that was inhibited by curcumin. Therefore, our findings would provide a new insight into the use of curcumin against OSCC in future.

  8. miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway

    SciTech Connect (OSTI)

    Zhang, Yu; Wei, Guangkuan; Di, Zhiyong; Zhao, Qingjie

    2014-09-26

    Graphical abstract: - Highlights: • Alcohol upregulates miR-339-5p expression. • miR-339-5p inhibits the NF-kB pathway. • miR-339-5p interacts with and blocks activity of IKK-beat and IKK-epsilon. • miR-339-5p modulates IL-1β, IL-6 and TNF-α. - Abstract: Alcohol-induced neuroinflammation is mediated by the innate immunesystem. Pro-inflammatory responses to alcohol are modulated by miRNAs. The miRNA miR-339-5p has previously been found to be upregulated in alcohol-induced neuroinflammation. However, little has been elucidated on the regulatory functions of this miRNA in alcohol-induced neuroinflammation. We investigated the function of miR-339-5p in alcohol exposed brain tissue and isolated microglial cells using ex vivo and in vitro techniques. Our results show that alcohol induces transcription of miR 339-5p, IL-6, IL-1β and TNF-α in mouse brain tissue and isolated microglial cells by activating NF-κB. Alcohol activation of NF-κB allows for nuclear translocation of the NF-κB subunit p65 and expression of pro-inflammatory mediators. miR-339-5p inhibited expression of these pro-inflammatory factors through the NF-κB pathway by abolishing IKK-β and IKK-ε activity.

  9. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Arkansas Electricity Profile 2014 Table 1. 2014 Summary statistics (Arkansas) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 14,754 30 Electric utilities 11,526 23 IPP & CHP 3,227 29 Net generation (megawatthours) 61,592,137 24 Electric utilities 48,752,895 18 IPP & CHP 12,839,241 28 Emissions Sulfur dioxide (short tons) 89,528 15 Nitrogen oxide (short tons) 47,048 20 Carbon dioxide (thousand metric tons) 37,289 23 Sulfur dioxide (lbs/MWh) 2.9 9 Nitrogen oxide

  10. Environmental profile of Paraguay

    SciTech Connect (OSTI)

    Not Available

    1985-12-01

    The social, cultural, physical, and economic dimensions of Paraguay's environment are analyzed to identify main environmental features and problems and to recommend specific actions. The environmental profile presents an overview of Paraguay's ethno-historic and anthropological background, present-day society, and the impact of pollution. Descriptions are presented of: the legal and institutional aspects of environmental policy; the structure and performance of the economy, with focus on the primary and energy sectors; physical resources (climate, geological, mineral, soil, and water resources); and biological resources (vegetation, wild animal life, protected areas, and fish resources).

  11. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Vermont profile Vermont total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 620 55.0 4,782 72.2 Hydro and Pumped Storage 324 28.7 1,347 20.3 Natural Gas - - 4 0.1 Other Renewable1 84 7.5 482 7.3 Petroleum 100 8.9 5 0.1 Total 1,128 100.0 6,620 100.0 1Municipal Solid Waste net generation is allocated according to the

  12. Profile Interface Generator

    Energy Science and Technology Software Center (OSTI)

    2013-11-09

    The Profile Interface Generator (PIG) is a tool for loosely coupling applications and performance tools. It enables applications to write code that looks like standard C and Fortran functions calls, without requiring that applications link to specific implementations of those function calls. Performance tools can register with PIG in order to listen to only the calls that give information they care about. This interface reduces the build and configuration burden on application developers and allowsmore » semantic instrumentation to live in production codes without interfering with production runs.« less

  13. Compare Gene Profiles

    Energy Science and Technology Software Center (OSTI)

    2014-05-31

    Compare Gene Profiles (CGP) performs pairwise gene content comparisons among a relatively large set of related bacterial genomes. CGP performs pairwise BLAST among gene calls from a set of input genome and associated annotation files, and combines the results to generate lists of common genes, unique genes, homologs, and genes from each genome that differ substantially in length from corresponding genes in the other genomes. CGP is implemented in Python and runs in a Linuxmore » environment in serial or parallel mode.« less

  14. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Alaska Electricity Profile 2014 Table 1. 2014 Summary statistics (Alaska) Item Value Rank Primary energy source Natural gas Net summer capacity (megawatts) 2,464 48 Electric utilities 2,313 39 IPP & CHP 151 50 Net generation (megawatthours) 6,042,830 50 Electric utilities 5,509,991 40 IPP & CHP 532,839 50 Emissions Sulfur dioxide (short tons) 4,129 43 Nitrogen oxide (short tons) 19,281 38 Carbon dioxide (thousand metric tons) 3,558 44 Sulfur dioxide (lbs/MWh) 1.4 28 Nitrogen oxide

  15. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Arizona Electricity Profile 2014 Table 1. 2014 Summary statistics (Arizona) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 28,249 13 Electric utilities 21,311 11 IPP & CHP 6,938 17 Net generation (megawatthours) 112,257,187 13 Electric utilities 94,847,135 8 IPP & CHP 17,410,053 19 Emissions Sulfur dioxide (short tons) 22,597 32 Nitrogen oxide (short tons) 56,726 17 Carbon dioxide (thousand metric tons) 53,684 16 Sulfur dioxide (lbs/MWh) 0.4 41 Nitrogen oxide

  16. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    California Electricity Profile 2014 Table 1. 2014 Summary statistics (California) Item Value Rank Primary energy source Natural gas Net summer capacity (megawatts) 74,646 2 Electric utilities 28,201 4 IPP & CHP 46,446 2 Net generation (megawatthours) 198,807,622 5 Electric utilities 71,037,135 14 IPP & CHP 127,770,487 4 Emissions Sulfur dioxide (short tons) 3,102 46 Nitrogen oxide (short tons) 98,348 5 Carbon dioxide (thousand metric tons) 57,223 14 Sulfur dioxide (lbs/MWh) 0.0 49

  17. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Colorado Electricity Profile 2014 Table 1. 2014 Summary statistics (Colorado) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 14,933 29 Electric utilities 10,204 28 IPP & CHP 4,729 18 Net generation (megawatthours) 53,847,386 30 Electric utilities 43,239,615 26 IPP & CHP 10,607,771 30 Emissions Sulfur dioxide (short tons) 28,453 30 Nitrogen oxide (short tons) 44,349 24 Carbon dioxide (thousand metric tons) 38,474 22 Sulfur dioxide (lbs/MWh) 1.1 32 Nitrogen

  18. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Connecticut Electricity Profile 2014 Table 1. 2014 Summary statistics (Connecticut) Item Value Rank Primary energy source Nuclear Net summer capacity (megawatts) 8,832 35 Electric utilities 161 45 IPP & CHP 8,671 12 Net generation (megawatthours) 33,676,980 38 Electric utilities 54,693 45 IPP & CHP 33,622,288 11 Emissions Sulfur dioxide (short tons) 1,897 47 Nitrogen oxide (short tons) 8,910 45 Carbon dioxide (thousand metric tons) 7,959 41 Sulfur dioxide (lbs/MWh) 0.1 46 Nitrogen oxide

  19. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Delaware Electricity Profile 2014 Table 1. 2014 Summary statistics (Delaware) Item Value U.S. rank Primary energy source Natural gas Net summer capacity (megawatts) 3,086 46 Electric utilities 102 46 IPP & CHP 2,984 31 Net generation (megawatthours) 7,703,584 47 Electric utilities 49,050 46 IPP & CHP 7,654,534 35 Emissions Sulfur dioxide (short tons) 824 48 Nitrogen oxide (short tons) 2,836 48 Carbon dioxide (thousand metric tons) 4,276 43 Sulfur dioxide (lbs/MWh) 0.2 45 Nitrogen oxide

  20. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    District of Columbia Electricity Profile 2014 Table 1. 2014 Summary statistics (District of Columbia) Item Value Rank Primary energy source Natural gas Net summer capacity (megawatts) 9 51 Electric utilities IPP & CHP 9 51 Net generation (megawatthours) 67,612 51 Electric utilities IPP & CHP 67,612 51 Emissions Sulfur dioxide (short tons) 0 51 Nitrogen oxide (short tons) 147 51 Carbon dioxide (thousand metric tons) 48 50 Sulfur dioxide (lbs/MWh) 0.0 51 Nitrogen oxide (lbs/MWh) 4.3 3

  1. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Florida Electricity Profile 2014 Table 1. 2014 Summary statistics (Florida) Item Value Rank Primary energy source Natural gas Net summer capacity (megawatts) 59,440 3 Electric utilities 51,775 1 IPP & CHP 7,665 15 Net generation (megawatthours) 230,015,937 2 Electric utilities 211,970,587 1 IPP & CHP 18,045,350 15 Emissions Sulfur dioxide (short tons) 126,600 10 Nitrogen oxide (short tons) 91,356 6 Carbon dioxide (thousand metric tons) 111,549 2 Sulfur dioxide (lbs/MWh) 1.1 30 Nitrogen

  2. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Georgia Electricity Profile 2014 Table 1. 2014 Summary statistics (Georgia) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 38,250 7 Electric utilities 28,873 3 IPP & CHP 9,377 10 Net generation (megawatthours) 125,837,224 10 Electric utilities 109,523,336 4 IPP & CHP 16,313,888 20 Emissions Sulfur dioxide (short tons) 105,998 11 Nitrogen oxide (short tons) 58,144 14 Carbon dioxide (thousand metric tons) 62,516 12 Sulfur dioxide (lbs/MWh) 1.7 24 Nitrogen oxide

  3. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Hawaii Electricity Profile 2014 Table 1. 2014 Summary statistics (Hawaii) Item Value Rank Primary energy source Petroleum Net summer capacity (megawatts) 2,672 47 Electric utilities 1,732 40 IPP & CHP 939 45 Net generation (megawatthours) 10,204,158 46 Electric utilities 5,517,389 39 IPP & CHP 4,686,769 40 Emissions Sulfur dioxide (short tons) 21,670 33 Nitrogen oxide (short tons) 26,928 31 Carbon dioxide (thousand metric tons) 7,313 42 Sulfur dioxide (lbs/MWh) 4.2 4 Nitrogen oxide

  4. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Idaho Electricity Profile 2014 Table 1. 2014 Summary statistics (Idaho) Item Value Rank Primary energy source Hydroelectric Net summer capacity (megawatts) 4,944 42 Electric utilities 3,413 37 IPP & CHP 1,531 39 Net generation (megawatthours) 15,184,417 43 Electric utilities 9,628,016 37 IPP & CHP 5,556,400 39 Emissions Sulfur dioxide (short tons) 5,777 42 Nitrogen oxide (short tons) 20,301 37 Carbon dioxide (thousand metric tons) 1,492 49 Sulfur dioxide (lbs/MWh) 0.8 36 Nitrogen oxide

  5. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Illinois Electricity Profile 2014 Table 1. 2014 Summary statistics (Illinois) Item Value Rank Primary energy source Nuclear Net summer capacity (megawatts) 44,727 4 Electric utilities 5,263 35 IPP & CHP 39,464 4 Net generation (megawatthours) 202,143,878 4 Electric utilities 10,457,398 36 IPP & CHP 191,686,480 3 Emissions Sulfur dioxide (short tons) 187,536 6 Nitrogen oxide (short tons) 58,076 15 Carbon dioxide (thousand metric tons) 96,624 6 Sulfur dioxide (lbs/MWh) 1.9 20 Nitrogen

  6. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Indiana Electricity Profile 2014 Table 1. 2014 Summary statistics (Indiana) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 27,499 14 Electric utilities 23,319 7 IPP & CHP 4,180 23 Net generation (megawatthours) 115,395,392 12 Electric utilities 100,983,285 6 IPP & CHP 14,412,107 22 Emissions Sulfur dioxide (short tons) 332,396 3 Nitrogen oxide (short tons) 133,412 3 Carbon dioxide (thousand metric tons) 103,391 3 Sulfur dioxide (lbs/MWh) 5.8 1 Nitrogen oxide

  7. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Iowa Electricity Profile 2014 Table 1. 2014 Summary statistics (Iowa) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 16,507 24 Electric utilities 12,655 20 IPP & CHP 3,852 25 Net generation (megawatthours) 56,853,282 28 Electric utilities 43,021,954 27 IPP & CHP 13,831,328 25 Emissions Sulfur dioxide (short tons) 74,422 19 Nitrogen oxide (short tons) 41,793 25 Carbon dioxide (thousand metric tons) 39,312 21 Sulfur dioxide (lbs/MWh) 2.6 13 Nitrogen oxide

  8. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Kansas Electricity Profile 2014 Table 1. 2014 Summary statistics (Kansas) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 14,227 31 Electric utilities 11,468 24 IPP & CHP 2,759 33 Net generation (megawatthours) 49,728,363 31 Electric utilities 39,669,629 29 IPP & CHP 10,058,734 31 Emissions Sulfur dioxide (short tons) 31,550 29 Nitrogen oxide (short tons) 29,014 29 Carbon dioxide (thousand metric tons) 31,794 29 Sulfur dioxide (lbs/MWh) 1.3 29 Nitrogen oxide

  9. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Kentucky Electricity Profile 2014 Table 1. 2014 Summary statistics (Kentucky) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 20,878 21 Electric utilities 19,473 15 IPP & CHP 1,405 40 Net generation (megawatthours) 90,896,435 17 Electric utilities 90,133,403 10 IPP & CHP 763,032 49 Emissions Sulfur dioxide (short tons) 204,873 5 Nitrogen oxide (short tons) 89,253 7 Carbon dioxide (thousand metric tons) 85,795 7 Sulfur dioxide (lbs/MWh) 4.5 3 Nitrogen oxide

  10. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Louisiana Electricity Profile 2014 Table 1. 2014 Summary statistics (Louisiana) Item Value Rank Primary energy source Natural gas Net summer capacity (megawatts) 26,657 15 Electric utilities 18,120 16 IPP & CHP 8,537 13 Net generation (megawatthours) 104,229,402 15 Electric utilities 58,518,271 17 IPP & CHP 45,711,131 8 Emissions Sulfur dioxide (short tons) 96,240 14 Nitrogen oxide (short tons) 83,112 8 Carbon dioxide (thousand metric tons) 57,137 15 Sulfur dioxide (lbs/MWh) 1.8 21

  11. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Maine Electricity Profile 2014 Table 1. 2014 Summary statistics (Maine) Item Value Rank Primary energy source Natural gas Net summer capacity (megawatts) 4,470 43 Electric utilities 10 49 IPP & CHP 4,460 20 Net generation (megawatthours) 13,248,710 44 Electric utilities 523 49 IPP & CHP 13,248,187 27 Emissions Sulfur dioxide (short tons) 10,990 38 Nitrogen oxide (short tons) 8,622 46 Carbon dioxide (thousand metric tons) 3,298 46 Sulfur dioxide (lbs/MWh) 1.7 25 Nitrogen oxide (lbs/MWh)

  12. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Maryland Electricity Profile 2014 Table 1. 2014 Summary statistics (Maryland) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 12,264 33 Electric utilities 85 47 IPP & CHP 12,179 8 Net generation (megawatthours) 37,833,652 35 Electric utilities 20,260 47 IPP & CHP 37,813,392 9 Emissions Sulfur dioxide (short tons) 41,370 26 Nitrogen oxide (short tons) 20,626 35 Carbon dioxide (thousand metric tons) 20,414 34 Sulfur dioxide (lbs/MWh) 2.2 18 Nitrogen oxide

  13. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Massachusetts Electricity Profile 2014 Table 1. 2014 Summary statistics (Massachusetts) Item Value Rank Primary energy source Natural gas Net summer capacity (megawatts) 13,128 32 Electric utilities 971 42 IPP & CHP 12,157 9 Net generation (megawatthours) 31,118,591 40 Electric utilities 679,986 43 IPP & CHP 30,438,606 12 Emissions Sulfur dioxide (short tons) 6,748 41 Nitrogen oxide (short tons) 13,831 43 Carbon dioxide (thousand metric tons) 12,231 39 Sulfur dioxide (lbs/MWh) 0.4 40

  14. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Michigan Electricity Profile 2014 Table 1. 2014 Summary statistics (Michigan) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 30,435 12 Electric utilities 22,260 9 IPP & CHP 8,175 14 Net generation (megawatthours) 106,816,991 14 Electric utilities 84,075,322 12 IPP & CHP 22,741,669 13 Emissions Sulfur dioxide (short tons) 173,521 7 Nitrogen oxide (short tons) 77,950 9 Carbon dioxide (thousand metric tons) 64,062 11 Sulfur dioxide (lbs/MWh) 3.2 7 Nitrogen oxide

  15. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Minnesota Electricity Profile 2014 Table 1. 2014 Summary statistics (Minnesota) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 15,621 28 Electric utilities 11,557 22 IPP & CHP 4,064 24 Net generation (megawatthours) 56,998,330 27 Electric utilities 45,963,271 22 IPP & CHP 11,035,059 29 Emissions Sulfur dioxide (short tons) 39,272 27 Nitrogen oxide (short tons) 38,373 28 Carbon dioxide (thousand metric tons) 32,399 28 Sulfur dioxide (lbs/MWh) 1.4 27 Nitrogen

  16. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Mississippi Electricity Profile 2014 Table 1. 2014 Summary statistics (Mississippi) Item Value Rank Primary energy source Natural gas Net summer capacity (megawatts) 16,090 26 Electric utilities 13,494 19 IPP & CHP 2,597 34 Net generation (megawatthours) 55,127,092 29 Electric utilities 47,084,382 21 IPP & CHP 8,042,710 34 Emissions Sulfur dioxide (short tons) 101,093 13 Nitrogen oxide (short tons) 23,993 32 Carbon dioxide (thousand metric tons) 24,037 33 Sulfur dioxide (lbs/MWh) 3.7 5

  17. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Missouri Electricity Profile 2014 Table 1. 2014 Summary statistics (Missouri) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 21,790 19 Electric utilities 20,538 13 IPP & CHP 1,252 42 Net generation (megawatthours) 87,834,468 18 Electric utilities 85,271,253 11 IPP & CHP 2,563,215 46 Emissions Sulfur dioxide (short tons) 149,842 9 Nitrogen oxide (short tons) 77,749 10 Carbon dioxide (thousand metric tons) 75,735 8 Sulfur dioxide (lbs/MWh) 3.4 6 Nitrogen oxide

  18. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Montana Electricity Profile 2014 Table 1. 2014 Summary statistics (Montana) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 6,330 41 Electric utilities 3,209 38 IPP & CHP 3,121 30 Net generation (megawatthours) 30,257,616 41 Electric utilities 12,329,411 35 IPP & CHP 17,928,205 16 Emissions Sulfur dioxide (short tons) 14,426 34 Nitrogen oxide (short tons) 20,538 36 Carbon dioxide (thousand metric tons) 17,678 36 Sulfur dioxide (lbs/MWh) 1.0 34 Nitrogen oxide

  19. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Nebraska Electricity Profile 2014 Table 1. 2014 Summary statistics (Nebraska) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 8,732 36 Electric utilities 7,913 30 IPP & CHP 819 46 Net generation (megawatthours) 39,431,291 34 Electric utilities 36,560,960 30 IPP & CHP 2,870,331 45 Emissions Sulfur dioxide (short tons) 63,994 22 Nitrogen oxide (short tons) 27,045 30 Carbon dioxide (thousand metric tons) 26,348 31 Sulfur dioxide (lbs/MWh) 3.2 8 Nitrogen oxide

  20. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Nevada Electricity Profile 2014 Table 1. 2014 Summary statistics (Nevada) Item Value Rank Primary energy source Natural gas Net summer capacity (megawatts) 10,485 34 Electric utilities 8,480 29 IPP & CHP 2,006 35 Net generation (megawatthours) 36,000,537 37 Electric utilities 27,758,728 33 IPP & CHP 8,241,809 33 Emissions Sulfur dioxide (short tons) 10,229 40 Nitrogen oxide (short tons) 18,606 39 Carbon dioxide (thousand metric tons) 16,222 37 Sulfur dioxide (lbs/MWh) 0.4 38 Nitrogen

  1. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Hampshire Electricity Profile 2013 Table 1. 2013 Summary statistics (New Hampshire) Item Value Rank Primary energy source Nuclear Net summer capacity (megawatts) 4,413 44 Electric utilities 1,121 41 IPP & CHP 3,292 30 Net generation (megawatthours) 19,778,520 42 Electric utilities 2,266,903 41 IPP & CHP 17,511,617 20 Emissions Sulfur dioxide (short tons) 3,733 44 Nitrogen oxide (short tons) 5,057 47 Carbon dioxide (thousand metric tons) 3,447 46 Sulfur dioxide (lbs/MWh) 0.4 45 Nitrogen

  2. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Jersey Electricity Profile 2014 Table 1. 2014 Summary statistics (New Jersey) Item Value Rank Primary energy source Nuclear Net summer capacity (megawatts) 19,399 22 Electric utilities 544 43 IPP & CHP 18,852 7 Net generation (megawatthours) 68,051,086 23 Electric utilities -117,003 50 IPP & CHP 68,168,089 7 Emissions Sulfur dioxide (short tons) 3,369 44 Nitrogen oxide (short tons) 15,615 41 Carbon dioxide (thousand metric tons) 17,905 35 Sulfur dioxide (lbs/MWh) 0.1 47 Nitrogen oxide

  3. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Mexico Electricity Profile 2014 Table 1. 2014 Summary statistics (New Mexico) Item Value U.S. Rank Primary energy source Coal Net summer capacity (megawatts) 8,072 39 Electric utilities 6,094 33 IPP & CHP 1,978 37 Net generation (megawatthours) 32,306,210 39 Electric utilities 26,422,867 34 IPP & CHP 5,883,343 38 Emissions Sulfur dioxide (short tons) 12,064 37 Nitrogen oxide (short tons) 46,192 22 Carbon dioxide (thousand metric tons) 24,712 32 Sulfur dioxide (lbs/MWh) 0.7 37 Nitrogen

  4. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    York Electricity Profile 2014 Table 1. 2014 Summary statistics (New York) Item Value Rank Primary energy source Natural Gas Net summer capacity (megawatts) 40,404 6 Electric utilities 10,989 27 IPP & CHP 29,416 5 Net generation (megawatthours) 137,122,202 7 Electric utilities 34,082 31 IPP & CHP 103,039,347 5 Emissions Sulfur dioxide (short tons) 31,878 28 Nitrogen oxide (short tons) 46,971 21 Carbon dioxide (thousand metric tons) 33,240 26 Sulfur dioxide (lbs/MWh) 0.5 39 Nitrogen oxide

  5. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Carolina Electricity Profile 2013 Table 1. 2013 Summary statistics (North Carolina) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 30,048 12 Electric utilities 26,706 6 IPP & CHP 3,342 29 Net generation (megawatthours) 125,936,293 9 Electric utilities 116,317,050 2 IPP & CHP 9,619,243 31 Emissions Sulfur dioxide (short tons) 71,293 20 Nitrogen oxide (short tons) 62,397 12 Carbon dioxide (thousand metric tons) 56,940 14 Sulfur dioxide (lbs/MWh) 1.1 32 Nitrogen

  6. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Dakota Electricity Profile 2013 Table 1. 2013 Summary statistics (North Dakota) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 6,566 40 Electric utilities 5,292 34 IPP & CHP 1,274 41 Net generation (megawatthours) 35,021,673 39 Electric utilities 31,044,374 32 IPP & CHP 3,977,299 42 Emissions Sulfur dioxide (short tons) 56,854 23 Nitrogen oxide (short tons) 48,454 22 Carbon dioxide (thousand metric tons) 30,274 28 Sulfur dioxide (lbs/MWh) 3.2 11 Nitrogen oxide

  7. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Ohio Electricity Profile 2014 Table 1. 2014 Summary statistics (Ohio) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 31,507 9 Electric utilities 11,134 26 IPP & CHP 20,372 6 Net generation (megawatthours) 134,476,405 8 Electric utilities 43,290,512 25 IPP & CHP 91,185,893 7 Emissions Sulfur dioxide (short tons) 355,108 1 Nitrogen oxide (short tons) 105,688 4 Carbon dioxide (thousand metrictons) 98,650 5 Sulfur dioxide (lbs/MWh) 5.3 2 Nitrogen oxide (lbs/MWh)

  8. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Oklahoma Electricity Profile 2014 Table 1. 2014 Summary statistics (Oklahoma) Item Value Rank Primary energy source Natural gas Net summer capacity (megawatts) 24,048 17 Electric utilities 17,045 17 IPP & CHP 7,003 16 Net generation (megawatthours) 70,155,504 22 Electric utilities 48,096,026 19 IPP & CHP 22,059,478 14 Emissions Sulfur dioxide 78,556 18 Nitrogen oxide 44,874 23 Carbon dioxide (thousand metric tons) 43,994 18 Sulfur dioxide (lbs/MWh) 2.2 17 Nitrogen oxide (lbs/MWh) 1.3 26

  9. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Pennsylvania Electricity Profile 2014 Table 1. 2014 Summary statistics (Pennsylvania) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 42,723 5 Electric utilities 39 48 IPP & CHP 42,685 3 Net generation (megawatthours) 221,058,365 3 Electric utilities 90,994 44 IPP & CHP 220,967,371 2 Emissions Sulfur dioxide (short tons) 297,598 4 Nitrogen oxide (short tons) 141,486 2 Carbon dioxide (thousand metric tons) 101,361 4 Sulfur dioxide (lbs/MWh) 2.7 11 Nitrogen oxide

  10. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Carolina Electricity Profile 2014 Table 1. 2014 Summary statistics (South Carolina) Item Value Rank Primary energy source Nuclear Net summer capacity (megawatts) 22,824 18 Electric utilities 20,836 12 IPP & CHP 1,988 36 Net generation (megawatthours) 97,158,465 16 Electric utilities 93,547,004 9 IPP & CHP 3,611,461 43 Emissions Sulfur dioxide (short tons) 43,659 25 Nitrogen oxide (short tons) 21,592 34 Carbon dioxide (thousand metric tons) 33,083 27 Sulfur dioxide (lbs/MWh) 0.9 35

  11. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Tennessee Electricity Profile 2014 Table 1. 2014 Summary statistics (Tennessee) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 20,998 20 Electric utilities 20,490 14 IPP & CHP 508 47 Net generation (megawatthours) 79,506,886 20 Electric utilities 76,986,629 13 IPP & CHP 2,520,257 47 Emissions Sulfur dioxide (short tons) 89,357 16 Nitrogen oxide (short tons) 23,913 33 Carbon dioxide (thousand metric tons) 41,405 20 Sulfur dioxide (lbs/MWh) 2.2 16 Nitrogen oxide

  12. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Texas Electricity Profile 2014 Table 1. 2014 Summary statistics (Texas) Item Value Rank Primary energy source Natural gas Net summer capacity (megawatts) 112,914 1 Electric utilities 29,113 2 IPP & CHP 83,800 1 Net generation (megawatthours) 437,629,668 1 Electric utilities 94,974,953 7 IPP & CHP 342,654,715 1 Emissions Sulfur Dioxide (short tons) 349,245 2 Nitrogen Oxide short tons) 229,580 1 Carbon Dioxide (thousand metric tons) 254,488 1 Sulfur Dioxide (lbs/MWh) 1.6 26 Nitrogen Oxide

  13. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Utah Electricity Profile 2014 Table 1. 2014 Summary statistics (Utah) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 8,325 38 Electric utilities 7,296 31 IPP & CHP 1,029 44 Net generation (megawatthours) 43,784,526 33 Electric utilities 40,741,425 28 IPP & CHP 3,043,101 44 Emissions Sulfur Dioxide (short tons) 23,646 31 Nitrogen Oxide (short tons) 57,944 16 Carbon Dioxide (thousand metric tons) 35,179 24 Sulfur Dioxide (lbs/MWh) 1.1 31 Nitrogen Oxide (lbs/MWh)

  14. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Vermont Electricity Profile 2014 Table 1. 2014 Summary statistics (Vermont) Item Value Rank Primary energy source Nuclear Net summer capacity (megawatts) 650 50 Electric utilities 337 44 IPP & CHP 313 49 Net generation (megawatthours) 7,031,394 48 Electric utilities 868,079 42 IPP & CHP 6,163,315 37 Emissions Sulfur Dioxide (short tons) 71 50 Nitrogen Oxide (short tons) 737 50 Carbon Dioxide (thousand metric tons) 14 51 Sulfur Dioxide (lbs/MWh) 0.0 50 Nitrogen Oxide (lbs/MWh) 0.2 51

  15. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Virginia Electricity Profile 2014 Table 1. 2014 Summary statistics (Virginia) Item Value Rank Primary energy source Nuclear Net summer capacity (megawatts) 26,292 16 Electric utilities 22,062 10 IPP & CHP 4,231 22 Net generation (megawatthours) 77,137,438 21 Electric utilities 62,966,914 16 IPP & CHP 14,170,524 23 Emissions Sulfur Dioxide (short tons) 68,550 20 Nitrogen Oxide (short tons) 40,656 26 Carbon Dioxide (thousand metric tons) 33,295 25 Sulfur Dioxide (lbs/MWh) 1.8 23 Nitrogen

  16. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Wisconsin Electricity Profile 2014 Table 1. 2014 Summary statistics (Wisconsin) Item Value Rank Primary Energy Source Coal Net summer capacity (megawatts) 17,166 23 Electric utilities 14,377 18 IPP & CHP 2,788 32 Net generation (megawatthours) 61,064,796 25 Electric utilities 47,301,782 20 IPP & CHP 13,763,014 26 Emissions Sulfur Dioxide (short tons) 81,239 17 Nitrogen Oxide (short tons) 39,597 27 Carbon Dioxide (thousand metric tons) 43,750 19 Sulfur Dioxide (lbs/MWh) 2.7 12 Nitrogen

  17. EIA - State Electricity Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Wyoming Electricity Profile 2014 Table 1. 2014 Summary statistics (Wyoming) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 8,458 37 Electric utilities 7,233 32 IPP & CHP 1,225 43 Net generation (megawatthours) 49,696,183 32 Electric utilities 45,068,982 23 IPP & CHP 4,627,201 41 Emissions Sulfur Dioxide (short tons) 45,704 24 Nitrogen Oxide (short tons) 49,638 18 Carbon Dioxide (thousand metric tons) 47,337 17 Sulfur Dioxide (lbs/MWh) 1.8 22 Nitrogen Oxide

  18. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Connecticut Electricity Profile 2014 Table 1. 2014 Summary statistics (Connecticut) Item Value Rank Primary energy source Nuclear Net summer capacity (megawatts) 8,832 35 Electric utilities 161 45 IPP & CHP 8,671 12 Net generation (megawatthours) 33,676,980 38 Electric utilities 54,693 45 IPP & CHP 33,622,288 11 Emissions Sulfur dioxide (short tons) 1,897 47 Nitrogen oxide (short tons) 8,910 45 Carbon dioxide (thousand metric tons) 7,959 41 Sulfur dioxide (lbs/MWh) 0.1 46 Nitrogen oxide

  19. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Delaware Electricity Profile 2014 Table 1. 2014 Summary statistics (Delaware) Item Value U.S. rank Primary energy source Natural gas Net summer capacity (megawatts) 3,086 46 Electric utilities 102 46 IPP & CHP 2,984 31 Net generation (megawatthours) 7,703,584 47 Electric utilities 49,050 46 IPP & CHP 7,654,534 35 Emissions Sulfur dioxide (short tons) 824 48 Nitrogen oxide (short tons) 2,836 48 Carbon dioxide (thousand metric tons) 4,276 43 Sulfur dioxide (lbs/MWh) 0.2 45 Nitrogen oxide

  20. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Idaho Electricity Profile 2014 Table 1. 2014 Summary statistics (Idaho) Item Value Rank Primary energy source Hydroelectric Net summer capacity (megawatts) 4,944 42 Electric utilities 3,413 37 IPP & CHP 1,531 39 Net generation (megawatthours) 15,184,417 43 Electric utilities 9,628,016 37 IPP & CHP 5,556,400 39 Emissions Sulfur dioxide (short tons) 5,777 42 Nitrogen oxide (short tons) 20,301 37 Carbon dioxide (thousand metric tons) 1,492 49 Sulfur dioxide (lbs/MWh) 0.8 36 Nitrogen oxide

  1. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Massachusetts Electricity Profile 2014 Table 1. 2014 Summary statistics (Massachusetts) Item Value Rank Primary energy source Natural gas Net summer capacity (megawatts) 13,128 32 Electric utilities 971 42 IPP & CHP 12,157 9 Net generation (megawatthours) 31,118,591 40 Electric utilities 679,986 43 IPP & CHP 30,438,606 12 Emissions Sulfur dioxide (short tons) 6,748 41 Nitrogen oxide (short tons) 13,831 43 Carbon dioxide (thousand metric tons) 12,231 39 Sulfur dioxide (lbs/MWh) 0.4 40

  2. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Michigan Electricity Profile 2014 Table 1. 2014 Summary statistics (Michigan) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 30,435 12 Electric utilities 22,260 9 IPP & CHP 8,175 14 Net generation (megawatthours) 106,816,991 14 Electric utilities 84,075,322 12 IPP & CHP 22,741,669 13 Emissions Sulfur dioxide (short tons) 173,521 7 Nitrogen oxide (short tons) 77,950 9 Carbon dioxide (thousand metric tons) 64,062 11 Sulfur dioxide (lbs/MWh) 3.2 7 Nitrogen oxide

  3. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Missouri Electricity Profile 2014 Table 1. 2014 Summary statistics (Missouri) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 21,790 19 Electric utilities 20,538 13 IPP & CHP 1,252 42 Net generation (megawatthours) 87,834,468 18 Electric utilities 85,271,253 11 IPP & CHP 2,563,215 46 Emissions Sulfur dioxide (short tons) 149,842 9 Nitrogen oxide (short tons) 77,749 10 Carbon dioxide (thousand metric tons) 75,735 8 Sulfur dioxide (lbs/MWh) 3.4 6 Nitrogen oxide

  4. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Montana Electricity Profile 2014 Table 1. 2014 Summary statistics (Montana) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 6,330 41 Electric utilities 3,209 38 IPP & CHP 3,121 30 Net generation (megawatthours) 30,257,616 41 Electric utilities 12,329,411 35 IPP & CHP 17,928,205 16 Emissions Sulfur dioxide (short tons) 14,426 34 Nitrogen oxide (short tons) 20,538 36 Carbon dioxide (thousand metric tons) 17,678 36 Sulfur dioxide (lbs/MWh) 1.0 34 Nitrogen oxide

  5. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Nebraska Electricity Profile 2014 Table 1. 2014 Summary statistics (Nebraska) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 8,732 36 Electric utilities 7,913 30 IPP & CHP 819 46 Net generation (megawatthours) 39,431,291 34 Electric utilities 36,560,960 30 IPP & CHP 2,870,331 45 Emissions Sulfur dioxide (short tons) 63,994 22 Nitrogen oxide (short tons) 27,045 30 Carbon dioxide (thousand metric tons) 26,348 31 Sulfur dioxide (lbs/MWh) 3.2 8 Nitrogen oxide

  6. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Nevada Electricity Profile 2014 Table 1. 2014 Summary statistics (Nevada) Item Value Rank Primary energy source Natural gas Net summer capacity (megawatts) 10,485 34 Electric utilities 8,480 29 IPP & CHP 2,006 35 Net generation (megawatthours) 36,000,537 37 Electric utilities 27,758,728 33 IPP & CHP 8,241,809 33 Emissions Sulfur dioxide (short tons) 10,229 40 Nitrogen oxide (short tons) 18,606 39 Carbon dioxide (thousand metric tons) 16,222 37 Sulfur dioxide (lbs/MWh) 0.4 38 Nitrogen

  7. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Hampshire Electricity Profile 2013 Table 1. 2013 Summary statistics (New Hampshire) Item Value Rank Primary energy source Nuclear Net summer capacity (megawatts) 4,413 44 Electric utilities 1,121 41 IPP & CHP 3,292 30 Net generation (megawatthours) 19,778,520 42 Electric utilities 2,266,903 41 IPP & CHP 17,511,617 20 Emissions Sulfur dioxide (short tons) 3,733 44 Nitrogen oxide (short tons) 5,057 47 Carbon dioxide (thousand metric tons) 3,447 46 Sulfur dioxide (lbs/MWh) 0.4 45 Nitrogen

  8. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Jersey Electricity Profile 2014 Table 1. 2014 Summary statistics (New Jersey) Item Value Rank Primary energy source Nuclear Net summer capacity (megawatts) 19,399 22 Electric utilities 544 43 IPP & CHP 18,852 7 Net generation (megawatthours) 68,051,086 23 Electric utilities -117,003 50 IPP & CHP 68,168,089 7 Emissions Sulfur dioxide (short tons) 3,369 44 Nitrogen oxide (short tons) 15,615 41 Carbon dioxide (thousand metric tons) 17,905 35 Sulfur dioxide (lbs/MWh) 0.1 47 Nitrogen oxide

  9. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Mexico Electricity Profile 2014 Table 1. 2014 Summary statistics (New Mexico) Item Value U.S. Rank Primary energy source Coal Net summer capacity (megawatts) 8,072 39 Electric utilities 6,094 33 IPP & CHP 1,978 37 Net generation (megawatthours) 32,306,210 39 Electric utilities 26,422,867 34 IPP & CHP 5,883,343 38 Emissions Sulfur dioxide (short tons) 12,064 37 Nitrogen oxide (short tons) 46,192 22 Carbon dioxide (thousand metric tons) 24,712 32 Sulfur dioxide (lbs/MWh) 0.7 37 Nitrogen

  10. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    York Electricity Profile 2014 Table 1. 2014 Summary statistics (New York) Item Value Rank Primary energy source Natural Gas Net summer capacity (megawatts) 40,404 6 Electric utilities 10,989 27 IPP & CHP 29,416 5 Net generation (megawatthours) 137,122,202 7 Electric utilities 34,082 31 IPP & CHP 103,039,347 5 Emissions Sulfur dioxide (short tons) 31,878 28 Nitrogen oxide (short tons) 46,971 21 Carbon dioxide (thousand metric tons) 33,240 26 Sulfur dioxide (lbs/MWh) 0.5 39 Nitrogen oxide

  11. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Carolina Electricity Profile 2013 Table 1. 2013 Summary statistics (North Carolina) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 30,048 12 Electric utilities 26,706 6 IPP & CHP 3,342 29 Net generation (megawatthours) 125,936,293 9 Electric utilities 116,317,050 2 IPP & CHP 9,619,243 31 Emissions Sulfur dioxide (short tons) 71,293 20 Nitrogen oxide (short tons) 62,397 12 Carbon dioxide (thousand metric tons) 56,940 14 Sulfur dioxide (lbs/MWh) 1.1 32 Nitrogen

  12. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Dakota Electricity Profile 2013 Table 1. 2013 Summary statistics (North Dakota) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 6,566 40 Electric utilities 5,292 34 IPP & CHP 1,274 41 Net generation (megawatthours) 35,021,673 39 Electric utilities 31,044,374 32 IPP & CHP 3,977,299 42 Emissions Sulfur dioxide (short tons) 56,854 23 Nitrogen oxide (short tons) 48,454 22 Carbon dioxide (thousand metric tons) 30,274 28 Sulfur dioxide (lbs/MWh) 3.2 11 Nitrogen oxide

  13. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Oregon Electricity Profile 2014 Table 1. 2014 Summary statistics (Oregon) Item Value Rank Primary energy source Hydroelectric Net summer capacity (megawatts) 15,884 27 Electric utilities 11,175 25 IPP & CHP 4,709 19 Net generation (megawatthours) 60,119,907 26 Electric utilities 44,565,239 24 IPP & CHP 15,554,668 21 Emissions Sulfur dioxide (short tons) 10,595 39 Nitrogen oxide (short tons) 14,313 42 Carbon dioxide (thousand metric tons) 8,334 40 Sulfur dioxide (lbs/MWh) 0.4 42 Nitrogen

  14. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Pennsylvania Electricity Profile 2014 Table 1. 2014 Summary statistics (Pennsylvania) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 42,723 5 Electric utilities 39 48 IPP & CHP 42,685 3 Net generation (megawatthours) 221,058,365 3 Electric utilities 90,994 44 IPP & CHP 220,967,371 2 Emissions Sulfur dioxide (short tons) 297,598 4 Nitrogen oxide (short tons) 141,486 2 Carbon dioxide (thousand metric tons) 101,361 4 Sulfur dioxide (lbs/MWh) 2.7 11 Nitrogen oxide

  15. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Rhode Island Electricity Profile 2014 Table 1. 2014 Summary statistics (Rhode Island) Item Value Rank Primary energy source Natural gas Net summer capacity (megawatts) 1,810 49 Electric utilities 8 50 IPP & CHP 1,803 38 Net generation (megawatthours) 6,281,748 49 Electric utilities 10,670 48 IPP & CHP 6,271,078 36 Emissions Sulfur dioxide (short tons) 100 49 Nitrogen oxide (short tons) 1,224 49 Carbon dioxide (thousand metric tons) 2,566 48 Sulfur dioxide (lbs/MWh) 0.0 48 Nitrogen oxide

  16. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Carolina Electricity Profile 2014 Table 1. 2014 Summary statistics (South Carolina) Item Value Rank Primary energy source Nuclear Net summer capacity (megawatts) 22,824 18 Electric utilities 20,836 12 IPP & CHP 1,988 36 Net generation (megawatthours) 97,158,465 16 Electric utilities 93,547,004 9 IPP & CHP 3,611,461 43 Emissions Sulfur dioxide (short tons) 43,659 25 Nitrogen oxide (short tons) 21,592 34 Carbon dioxide (thousand metric tons) 33,083 27 Sulfur dioxide (lbs/MWh) 0.9 35

  17. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    South Dakota Electricity Profile 2014 Table 1. 2014 Summary statistics (South Dakota) Item Value Rank Primary energy source Hydroelectric Net summer capacity (megawatts) 3,948 45 Electric utilities 3,450 36 IPP & CHP 499 48 Net generation (megawatthours) 10,995,240 45 Electric utilities 9,344,872 38 IPP & CHP 1,650,368 48 Emissions Sulfur dioxide (short tons) 13,852 35 Nitrogen oxide (short tons) 10,638 44 Carbon dioxide (thousand metric tons) 3,093 47 Sulfur dioxide (lbs/MWh) 2.5 15

  18. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Washington Electricity Profile 2014 Table 1. 2014 Summary statistics (Washington) Item Value Rank Primary energy source Hydroelectric Net summer capacity (megawatts) 30,949 10 Electric utilities 27,376 5 IPP & CHP 3,573 26 Net generation (megawatthours) 116,334,363 11 Electric utilities 102,294,256 5 IPP & CHP 14,040,107 24 Emissions Sulfur Dioxide (short tons) 13,716 36 Nitrogen Oxide (short tons) 18,316 40 Carbon Dioxide (thousand metric tons) 12,427 398 Sulfur Dioxide (lbs/MWh) 0.2 44

  19. EIA - State Electricity Profiles

    Gasoline and Diesel Fuel Update (EIA)

    West Virginia Electricity Profile 2014 Table 1. 2014 Summary statistics (West Virginia) Item Value Rank Primary energy source Coal Net summer capacity (megawatts) 16,276 25 Electric utilities 11,981 21 IPP & CHP 4,295 21 Net generation (megawatthours) 81,059,577 19 Electric utilities 63,331,833 15 IPP & CHP 17,727,743 17 Emissions Sulfur Dioxide (short tons) 102,406 12 Nitrogen Oxide (short tons) 72,995 11 Carbon Dioxide (thousand metric tons) 73,606 9 Sulfur Dioxide (lbs/MWh) 2.5 14

  20. Project Cost Profile Spreadsheet | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Project Cost Profile Spreadsheet Project Cost Profile Spreadsheet File Project Cost Profile Spreadsheet.xlsx More Documents & Publications Statement of Work (SOW) Template ...

  1. Port Huron, MI Liquefied Natural Gas Exports to Canada (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    to Canada (Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 1 2014 1 1 1 1 2 1 1 1 1 1 2015 1 1 1 1 1 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 08/31/2016 Next Release Date: 09/30/2016 Referring Pages: U.S. Liquefied Natural Gas Exports by Point of Exit Port Huron, MI Natural Gas Exports to Canad

  2. Post Mortem of 120k mi Light-Duty Urea SCR and DPF System | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Post Mortem of 120k mi Light-Duty Urea SCR and DPF System Post Mortem of 120k mi Light-Duty Urea SCR and DPF System Presentation given at the 2007 Diesel Engine-Efficiency & Emissions Research Conference (DEER 2007). 13-16 August, 2007, Detroit, Michigan. Sponsored by the U.S. Department of Energy's (DOE) Office of FreedomCAR and Vehicle Technologies (OFCVT). deer07_lambert.pdf (649.68 KB) More Documents & Publications Urea SCR and DPF System for Tier 2 Diesel Light-Duty

  3. Elevated lactate dehydrogenase activity and increased cardiovascular mortality in the arsenic-endemic areas of southwestern Taiwan

    SciTech Connect (OSTI)

    Liao, Ya-Tang; Chen, Chien-Jen; Li, Wan-Fen; Hsu, Ling-I; Tsai, Li-Yu; Huang, Yeou-Lih; Sun, Chien-Wen; Chen, Wei J.; Wang, Shu-Li

    2012-08-01

    Arsenic ingestion has been linked to increasing global prevalence of and mortality from cardiovascular disease (CVD); arsenic can be removed from drinking water to reduce related health effects. Lactate dehydrogenase (LDH) is used for the evaluation of acute arsenic toxicity in vivo and in vitro, but it is not validated for the evaluation of long-term, chronic arsenic exposure. The present study examined the long-term effect of chronic arsenic exposure on CVD and serum LDH levels, after consideration of arsenic metabolism capacity. A total of 380 subjects from an arseniasis-endemic area and 303 from a non-endemic area of southwestern Taiwan were recruited in 2002. Various urinary arsenic species were analyzed using high-performance liquid chromatography (HPLC) and hydride generation systems. Fasting serum was used for quantitative determination of the total LDH activity. A significant dose–response relationship was observed between arsenic exposure and LDH elevation, independent of urinary arsenic profiles (P < 0.001). Furthermore, abnormal LDH elevation was associated with CVD mortality after adjustment for Framingham risk scores for 10-year CVD and arsenic exposure (hazard ratio, 3.98; 95% confidence interval, 1.07–14.81). LDH was elevated in subjects with arsenic exposure in a dose-dependent manner. LDH is a marker of arsenic toxicity associated with CVD mortality. Results of this study have important implications for use in ascertaining long-term arsenic exposure risk of CVD. -- Highlights: ► We showed that arsenic exposure was correlated with LDH elevation. ► LDH elevation was related to arsenic methylation capacity. ► Abnormal LDH elevation can be a marker of susceptibility to CVD mortality.

  4. Deflagration Wave Profiles

    SciTech Connect (OSTI)

    Menikoff, Ralph

    2012-04-03

    Shock initiation in a plastic-bonded explosives (PBX) is due to hot spots. Current reactive burn models are based, at least heuristically, on the ignition and growth concept. The ignition phase occurs when a small localized region of high temperature (or hot spot) burns on a fast time scale. This is followed by a growth phase in which a reactive front spreads out from the hot spot. Propagating reactive fronts are deflagration waves. A key question is the deflagration speed in a PBX compressed and heated by a shock wave that generated the hot spot. Here, the ODEs for a steady deflagration wave profile in a compressible fluid are derived, along with the needed thermodynamic quantities of realistic equations of state corresponding to the reactants and products of a PBX. The properties of the wave profile equations are analyzed and an algorithm is derived for computing the deflagration speed. As an illustrative example, the algorithm is applied to compute the deflagration speed in shock compressed PBX 9501 as a function of shock pressure. The calculated deflagration speed, even at the CJ pressure, is low compared to the detonation speed. The implication of this are briefly discussed.

  5. MicroRNAs expression in ox-LDL treated HUVECs: MiR-365 modulates apoptosis and Bcl-2 expression

    SciTech Connect (OSTI)

    Qin, Bing; Xiao, Bo; Liang, Desheng; Xia, Jian; Li, Ye; Yang, Huan

    2011-06-24

    Highlights: {yields} We evaluated the role of miRNAs in ox-LDL induced apoptosis in ECs. {yields} We found 4 up-regulated and 11 down-regulated miRNAs in apoptotic ECs. {yields} Target genes of the dysregulated miRNAs regulate ECs apoptosis and atherosclerosis. {yields} MiR-365 promotes ECs apoptosis via suppressing Bcl-2 expression. {yields} MiR-365 inhibitor alleviates ECs apoptosis induced by ox-LDL. -- Abstract: Endothelial cells (ECs) apoptosis induced by oxidized low-density lipoprotein (ox-LDL) is thought to play a critical role in atherosclerosis. MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the expression of genes involved in diverse cell functions, including differentiation, growth, proliferation, and apoptosis. However, whether miRNAs are associated with ox-LDL induced apoptosis and their effect on ECs is still unknown. Therefore, this study evaluated potential miRNAs and their involvement in ECs apoptosis in response to ox-LDL stimulation. Microarray and qRT-PCR analysis performed on human umbilical vein endothelial cells (HUVECs) exposed to ox-LDL identified 15 differentially expressed (4 up- and 11 down-regulated) miRNAs. Web-based query tools were utilized to predict the target genes of the differentially expressed miRNAs, and the potential target genes were classified into different function categories with the gene ontology (GO) term and KEGG pathway annotation. In particular, bioinformatics analysis suggested that anti-apoptotic protein B-cell CLL/lymphoma 2 (Bcl-2) is a target gene of miR-365, an apoptomir up-regulated by ox-LDL stimulation in HUVECs. We further showed that transfection of miR-365 inhibitor partly restored Bcl-2 expression at both mRNA and protein levels, leading to a reduction of ox-LDL-mediated apoptosis in HUVECs. Taken together, our findings indicate that miRNAs participate in ox-LDL-mediated apoptosis in HUVECs. MiR-365 potentiates ox-LDL-induced ECs apoptosis by regulating the

  6. Study of catalysis of coal gasification at elevated pressures...

    Office of Scientific and Technical Information (OSTI)

    Study of catalysis of coal gasification at elevated pressures. Evaluation of 20 compounds at 850sup 0C Citation Details In-Document Search Title: Study of catalysis of coal ...

  7. Property:Building/SPElectrtyUsePercElevators | Open Energy Information

    Open Energy Info (EERE)

    ctrtyUsePercElevators" Showing 25 pages using this property. (previous 25) (next 25) S Sweden Building 05K0001 + 0.0 + Sweden Building 05K0002 + 0.125907012528 + Sweden Building...

  8. City and County of Denver- Elevations Energy Loans

    Broader source: Energy.gov [DOE]

    Elevations Credit Union has partnered with Boulder County and the City/County of Denver to offer this full-suite of services. Both EnergySmart and the Denver Energy Challenge help residents and b...

  9. MiRNA-125a-5p inhibits glioblastoma cell proliferation and promotes cell differentiation by targeting TAZ

    SciTech Connect (OSTI)

    Yuan, Jian; Xiao, Gelei; Peng, Gang; Liu, Dingyang; Wang, Zeyou; Liao, Yiwei; Liu, Qing; Wu, Minghua; Yuan, Xianrui

    2015-02-06

    Highlights: • Expression of miR-125a-5p is inversely correlated with that of TAZ in glioma cells. • MiR-125a-5p represses TAZ expression in glioma cells. • MiR-125a-5p directly targets the 3′ UTR of TAZ mRNA and promotes its degradation. • MiR-125a-5p represses CTGF and survivin via TAZ, and inhibits glioma cell growth. • MiR-125a-5p inhibits the stem cell features of HFU-251 MG cells. - Abstract: Glioblastoma (GBM) is the most lethal brain tumor due to the resistance to conventional therapies, such as radiotherapy and chemotherapy. TAZ, an important mediator of the Hippo pathway, was found to be up-regulated in diverse cancers, including in GBM, and plays important roles in tumor initiation and progression. However, little is known about the regulation of TAZ expression in tumors. In this study, we found that miR-125a-5p is an important regulator of TAZ in glioma cells by directly targeting the TAZ 3′ UTR. MiR-125a-5p levels are inversely correlated with that of TAZ in normal astrocytes and a panel of glioma cell lines. MiR-125a-5p represses the expression of TAZ target genes, including CTGF and survivin, and inhibits cell proliferation and induces the differentiation of GBM cells; whereas over-expression of TAZ rescues the effects of miR-125a-5p. This study revealed a mechanism for TAZ deregulation in glioma cells, and also demonstrated a tumor suppressor role of miR-125a-5p in glioblastoma cells.

  10. Beam Profile Monitor With Accurate Horizontal And Vertical Beam Profiles

    DOE Patents [OSTI]

    Havener, Charles C [Knoxville, TN; Al-Rejoub, Riad [Oak Ridge, TN

    2005-12-26

    A widely used scanner device that rotates a single helically shaped wire probe in and out of a particle beam at different beamline positions to give a pair of mutually perpendicular beam profiles is modified by the addition of a second wire probe. As a result, a pair of mutually perpendicular beam profiles is obtained at a first beamline position, and a second pair of mutually perpendicular beam profiles is obtained at a second beamline position. The simple modification not only provides more accurate beam profiles, but also provides a measurement of the beam divergence and quality in a single compact device.

  11. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    South Carolina profile South Carolina total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 6,486 27.0 51,988 49.9 Coal 7,230 30.1 37,671 36.2 Hydro and Pumped Storage 4,006 16.7 1,442 1.4 Natural Gas 5,308 22.1 10,927 10.5 Other 1 - - 61 0.1 Other Renewable1 284 1.2 1,873 1.8 Petroleum 670 2.8 191 0.2 Total 23,982

  12. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Tennessee profile Tennessee total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 3,401 15.9 27,739 33.7 Coal 8,805 41.1 43,670 53.0 Hydro and Pumped Storage 4,277 20.0 7,416 9.0 Natural Gas 4,655 21.7 2,302 2.8 Other 1 - - 16 * Other Renewable1 222 1.0 988 1.2 Petroleum 58 0.3 217 0.3 Total 21,417 100.0 82,349 100.0

  13. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Texas profile Texas total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 4,966 4.6 41,335 10.0 Coal 22,335 20.6 150,173 36.5 Hydro and Pumped Storage 689 0.6 1,262 0.3 Natural Gas 69,291 64.0 186,882 45.4 Other 1 477 0.4 3,630 0.9 Other Renewable1 10,295 9.5 27,705 6.7 Petroleum 204 0.2 708 0.2 Total 108,258 100.0

  14. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Virginia profile Virginia total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 3,501 14.5 26,572 36.4 Coal 5,868 24.3 25,459 34.9 Hydro and Pumped Storage 4,107 17.0 10 * Natural Gas 7,581 31.4 16,999 23.3 Other 1 - - 414 0.6 Other Renewable1 621 2.6 2,220 3.0 Petroleum 2,432 10.1 1,293 1.8 Total 24,109 100.0 72,966

  15. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Washington profile Washington total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 1,097 3.6 9,241 8.9 Coal 1,340 4.4 8,527 8.2 Hydro and Pumped Storage 21,495 70.5 68,342 66.0 Natural Gas 3,828 12.6 10,359 10.0 Other 1 - - 354 0.3 Other Renewable1 2,703 8.9 6,617 6.4 Petroleum 15 * 32 * Total 30,478 100.0 103,473

  16. EIA - State Nuclear Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Wisconsin profile Wisconsin total electric power industry, summer capacity and net generation, by energy source, 2010 Primary energy source Summer capacity (mw) Share of State total (percent) Net generation (thousand mwh) Share of State total (percent) Nuclear 1,584 8.9 13,281 20.7 Coal 8,063 45.2 40,169 62.5 Hydro and Pumped Storage 492 2.8 2,112 3.3 Natural Gas 6,110 34.3 5,497 8.5 Other 1 21 0.1 63 0.1 Other Renewable1 775 4.3 2,474 3.8 Petroleum 790 4.4 718 1.1 Total 17,836 100.0 64,314

  17. The NuMI proton beam at Fermilab successes and challenges

    SciTech Connect (OSTI)

    Childress, S.; /Fermilab

    2008-11-01

    The NuMI beam at Fermilab has delivered over 5 x 10{sup 20} 120 GeV protons to the neutrino production target since the start for MINOS [1] neutrino oscillation experiment operation in 2005. We report on proton beam commissioning and operation status, including successes and challenges with this beam.

  18. DOE Zero Energy Ready Home Case Study: Cobblestone Homes, Midland, MI

    Broader source: Energy.gov [DOE]

    Case study of a DOE Zero Energy Ready home in Midland, MI, that scored HERS 49 without PV or HERS 44 with 1.4 kW of PV. The custom home served as a prototype and energy efficiency demonstration...

  19. MiR-18a regulates the proliferation, migration and invasion of human glioblastoma cell by targeting neogenin

    SciTech Connect (OSTI)

    Song, Yichen; Wang, Ping; Zhao, Wei; Yao, Yilong; Liu, Xiaobai; Ma, Jun; Xue, Yixue; Liu, Yunhui

    2014-05-15

    MiR-17-92 cluster has recently been reported as an oncogene in some tumors. However, the association of miR-18a, an important member of this cluster, with glioblastoma remains unknown. Therefore, this study aims to investigate the expression of miR-18a in glioblastoma and its role in biological behavior of U87 and U251 human glioblastoma cell lines. Quantitative RT-PCR results showed that miR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines compared with that in human brain tissues and primary normal human astrocytes, and the expression levels were increased along with the rising pathological grades of glioblastoma. Neogenin was identified as the target gene of miR-18a by dual-luciferase reporter assays. RT-PCR and western blot results showed that its expression levels were decreased along with the rising pathological grades of glioblastoma. Inhibition of miR-18a expression was established by transfecting exogenous miR-18a inhibitor into U87 and U251 cells, and its effects on the biological behavior of glioblastoma cells were studied using CCK-8 assay, transwell assay and flow cytometry. Inhibition of miR-18a expression in U87 and U251 cells significantly up-regulated neogenin, and dramatically suppressed the abilities of cell proliferation, migration and invasion, induced cell cycle arrest and promoted cellular apoptosis. Collectively, these results suggest that miR-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin, and miR-18a can serve as a potential target in the treatment of glioblastoma. - Highlights: • MiR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines. • Neogenin was identified as the target gene of miR-18a. • Neogenin expressions were decreased along with the rising pathological grades of glioblastoma. • Inhibition of miR-18a suppressed biological behavior of glioma cells by up-regulating neogenin.

  20. EIA - Renewable Electricity State Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Electricity State Profiles Renewable Electricity State Profiles Data for 2010 | Release Date: January 21, 2012 | Next Release: January 30, 2013 Other Renewable Electricity State Profiles Choose a State: Select a State Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New

  1. EIA - Renewable Electricity State Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Electricity State Profiles Renewable Electricity State Profiles Data for 2010 | Release Date: January 21, 2012 | Next Release: January 30, 2013 Other Renewable Electricity State Profiles Choose a State: Select a State Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New

  2. EIA - Renewable Electricity State Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Electricity State Profiles Renewable Electricity State Profiles Data for 2010 | Release Date: January 21, 2012 | Next Release: January 30, 2013 Other Renewable Electricity State Profiles Choose a State: Select a State Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New

  3. EIA - Renewable Electricity State Profiles

    Gasoline and Diesel Fuel Update (EIA)

    Electricity State Profiles Renewable Electricity State Profiles Data for 2010 | Release Date: January 21, 2012 | Next Release: January 30, 2013 Other Renewable Electricity State Profiles Choose a State: Select a State Alabama Alaska Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New

  4. Impact of elevated nitrate on sulfate-reducing bacteria: A comparative study of Desulfovibrio vulgaris

    SciTech Connect (OSTI)

    He, Q.; He, Z.; Joyner, D.C.; Joachimiak, M.; Price, M.N.; Yang, Z.K.; Yen, H.-C. B.; Hemme, C. L.; Chen, W.; Fields, M.; Stahl, D. A.; Keasling, J. D.; Keller, M.; Arkin, A. P.; Hazen, T. C.; Wall, J. D.; Zhou, J.

    2010-07-15

    Sulfate-reducing bacteria have been extensively studied for their potential in heavy-metal bioremediation. However, the occurrence of elevated nitrate in contaminated environments has been shown to inhibit sulfate reduction activity. Although the inhibition has been suggested to result from the competition with nitrate-reducing bacteria, the possibility of direct inhibition of sulfate reducers by elevated nitrate needs to be explored. Using Desulfovibrio vulgaris as a model sulfate-reducing bacterium, functional genomics analysis reveals that osmotic stress contributed to growth inhibition by nitrate as shown by the upregulation of the glycine/betaine transporter genes and the relief of nitrate inhibition by osmoprotectants. The observation that significant growth inhibition was effected by 70 mM NaNO{sub 3} but not by 70 mM NaCl suggests the presence of inhibitory mechanisms in addition to osmotic stress. The differential expression of genes characteristic of nitrite stress responses, such as the hybrid cluster protein gene, under nitrate stress condition further indicates that nitrate stress response by D. vulgaris was linked to components of both osmotic and nitrite stress responses. The involvement of the oxidative stress response pathway, however, might be the result of a more general stress response. Given the low similarities between the response profiles to nitrate and other stresses, less-defined stress response pathways could also be important in nitrate stress, which might involve the shift in energy metabolism. The involvement of nitrite stress response upon exposure to nitrate may provide detoxification mechanisms for nitrite, which is inhibitory to sulfate-reducing bacteria, produced by microbial nitrate reduction as a metabolic intermediate and may enhance the survival of sulfate-reducing bacteria in environments with elevated nitrate level.

  5. Search Women@Energy Profiles

    Broader source: Energy.gov [DOE]

    Search the Women@Energy profiles to learn more about how to get into STEM, inspired by STEM, or find a STEM career.

  6. miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer

    SciTech Connect (OSTI)

    Li, Qiaoyan; Zhu, Fufan; Chen, Puxiang

    2012-07-20

    Highlights: Black-Right-Pointing-Pointer Both miR-7 and miR-218 down-regulates HoxB3 expression by targeting the 3 Prime -UTR of HoxB3 mRNA. Black-Right-Pointing-Pointer A reverse correlation between the levels of endogenous miR-7, miR218 and HoxB3 expression. Black-Right-Pointing-Pointer Epigenetic changes involve in the reactivation of HoxB3. Black-Right-Pointing-Pointer Both miRNAs inhibits the cell cycle and clone formation of breast cancer cells. -- Abstract: Many microRNAs have been implicated as key regulators of cellular growth and differentiation and have been found to dysregulate proliferation in human tumors, including breast cancer. Cancer-linked microRNAs also alter the epigenetic landscape by way of DNA methylation and post-translational modifications of histones. Aberrations in Hox gene expression are important for oncogene or tumor suppressor during abnormal development and malignancy. Although recent studies suggest that HoxB3 is critical in breast cancer, the putative role(s) of microRNAs impinging on HoxB3 is not yet fully understood. In this study, we found that the expression levels of miR-7 and miR-218 were strongly and reversely associated with HoxB3 expression. Stable overexpression of miR-7 and miR-218 was accompanied by reactivation of tumor suppressor genes including RASSF1A and Claudin-6 by means of epigenetic switches in DNA methylation and histone modification, giving rise to inhibition of the cell cycle and clone formation of breast cancer cells. The current study provides a novel link between overexpression of collinear Hox genes and multiple microRNAs in human breast malignancy.

  7. PSMB4 promotes multiple myeloma cell growth by activating NF-κB-miR-21 signaling

    SciTech Connect (OSTI)

    Zheng, Peihao; Guo, Honggang; Li, Guangchao; Han, Siqi; Luo, Fei; Liu, Yi

    2015-03-06

    Proteasomal subunit PSMB4, was recently identified as potential cancer driver genes in several tumors. However, the regulatory mechanism of PSMB4 on carcinogenesis process remains unclear. In this study, we investigated the expression and roles of PSMB4 in multiple myeloma (MM). We found a significant up-regulation of PSMB4 in MM plasma and cell lines. Ectopic overexpression of PSMB4 promoted cell growth and colony forming ability of MM cells, whereas inhibition of PSMB4 led to a decrease of such events. Furthermore, our results demonstrated the up-regulation of miR-21 and a positive correlation between the levels of miR-21 and PSMB4 in MM. Re-expression of miR-21 markedly rescued PSMB4 knockdown-mediated suppression of cell proliferation and clone-formation. Additionally, while enforced expression of PSMB4 profoundly increased NF-κB activity and the level of miR-21, PSMB4 knockdown or NF-κB inhibition suppressed miR-21 expression in MM cells. Taken together, our results demonstrated that PSMB4 regulated MM cell growth in part by activating NF-κB-miR-21 signaling, which may represent promising targets for novel specific therapies. - Highlights: • First reported upregulation of PSMB4 in MM plasma and cell lines. • PSMB4 promoted MM cell growth and colony forming ability. • Further found miR-21 was up-regulated by PSMB4 in MM plasma and cell lines. • PSMB4-induced miR-21 expression was modulated by NF-κB. • PSMB4-NF-κB-miR-21 axis may be potential therapeutic targets of MM.

  8. Steel Energy and Environmental Profile

    SciTech Connect (OSTI)

    none,

    2000-08-01

    Major steelmaking processes (from ironmaking through fabrication and forming) and their associated energy requirements have been profiled in this 2001 report (PDF 582 KB). This profile by Energetics, Inc. also describes the waste streams generated by each process and estimates annual emissions of CO2 and criteria pollutants.

  9. Laser heterodyne surface profiler

    DOE Patents [OSTI]

    Sommargren, G.E.

    1980-06-16

    A method and apparatus are disclosed for testing the deviation of the face of an object from a flat smooth surface using a beam of coherent light of two plane-polarized components, one of a frequency constantly greater than the other by a fixed amount to produce a difference frequency with a constant phase to be used as a reference, and splitting the beam into its two components. The separate components are directed onto spaced apart points on the face of the object to be tested for smoothness while the face of the object is rotated on an axis normal to one point, thereby passing the other component over a circular track on the face of the object. The two components are recombined after reflection to produce a reflected frequency difference of a phase proportional to the difference in path length of one component reflected from one point to the other component reflected from the other point. The phase of the reflected frequency difference is compared with the reference phase to produce a signal proportional to the deviation of the height of the surface along the circular track with respect to the fixed point at the center, thereby to produce a signal that is plotted as a profile of the surface along the circular track. The phase detector includes a quarter-wave plate to convert the components of the reference beam into circularly polarized components, a half-wave plate to shift the phase of the circularly polarized components, and a polarizer to produce a signal of a shifted phase for comparison with the phase of the frequency difference of the reflected components detected through a second polarizer. Rotation of the half-wave plate can be used for phase adjustment over a full 360/sup 0/ range.

  10. High-<mi>Tmi>c> superconductivity at the interface between the <mi>CaCuO>2 and <mi>SrTiO>3 insulating oxides

    SciTech Connect (OSTI)

    Di Castro, D.; Cantoni, C.; Ridolfi, F.; Aruta, C.; Tebano, A.; Yang, N.; Balestrino, G.

    2015-09-28

    At interfaces between complex oxides it is possible to generate electronic systems with unusual electronic properties, which are not present in the isolated oxides. One important example is the appearance of superconductivity at the interface between insulating oxides, although, until now, with very low Tc. We report the occurrence of high Tc superconductivity in the bilayer CaCuO2/SrTiO3, where both the constituent oxides are insulating. In order to obtain a superconducting state, the CaCuO2/SrTiO3 interface must be realized between the Ca plane of CaCuO2 and the TiO2 plane of SrTiO3. Only in this case can oxygen ions be incorporated in the interface Ca plane, acting as apical oxygen for Cu and providing holes to the CuO2 planes. In addition, a detailed hole doping spatial profile can be obtained by scanning transmission electron microscopy and electron-energy-loss spectroscopy at the O K edge, clearly showing that the (super)conductivity is confined to about 1–2 CaCuO2 unit cells close to the interface with SrTiO3. The results obtained for the CaCuO2/SrTiO3 interface can be extended to multilayered high Tc cuprates, contributing to explaining the dependence of Tc on the number of CuO2 planes in these systems.

  11. Neutron spectroscopic study of crystalline electric field excitations in stoichiometric and lightly stuffed <mi>Yb>2<mi>Ti>2<mi mathvariant='normal'>Omi>7

    SciTech Connect (OSTI)

    Gaudet, J.; Maharaj, D. D.; Sala, G.; Kermarrec, E.; Ross, K. A.; Dabkowska, H. A.; Kolesnikov, A. I.; Granroth, G. E.; Gaulin, B. D.

    2015-10-27

    Time-of-flight neutron spectroscopy has been used to determine the crystalline electric field Hamiltonian, eigenvalues and eigenvectors appropriate to the J=7/2 Yb3+ ion in the candidate quantum spin ice pyrochlore magnet Yb2Ti2O7. The precise ground state of this exotic, geometrically frustrated magnet is known to be sensitive to weak disorder associated with the growth of single crystals from the melt. Such materials display weak “stuffing,” wherein a small proportion, approximately 2%, of the nonmagnetic Ti4+ sites are occupied by excess Yb3+. We have carried out neutron spectroscopic measurements on a stoichiometric powder sample of Yb2Ti2O7, as well as a crushed single crystal with weak stuffing and an approximate composition of Yb2+xTi2–xO7+y with x = 0.046. All samples display three crystalline electric field transitions out of the ground state, and the ground state doublet itself is identified as primarily composed of mJ = ±1/2, as expected. However, stuffing at low temperatures in Yb2+xTi2–xO7+y induces a similar finite crystalline electric field lifetime as is induced in stoichiometric Yb2Ti2O7 by elevated temperature. In conclusion, an extended strain field exists about each local “stuffed” site, which produces a distribution of random crystalline electric field environments in the lightly stuffed Yb2+xTi2–xO7+y, in addition to producing a small fraction of Yb ions in defective environments with grossly different crystalline electric field eigenvalues and eigenvectors.

  12. Aryl hydrocarbon receptor-dependent regulation of miR-196a expression controls lung fibroblast apoptosis but not proliferation

    SciTech Connect (OSTI)

    Hecht, Emelia; Zago, Michela; Sarill, Miles; Rico de Souza, Angela; Gomez, Alvin; Matthews, Jason; Hamid, Qutayba; Eidelman, David H.; Baglole, Carolyn J.

    2014-11-01

    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor implicated in the regulation of apoptosis and proliferation. Although activation of the AhR by xenobiotics such as dioxin inhibits the cell cycle and control apoptosis, paradoxically, AhR expression also promotes cell proliferation and survival independent of exogenous ligands. The microRNA (miRNA) miR-196a has also emerged as a regulator of proliferation and apoptosis but a relationship between the AhR and miR-196a is not known. Therefore, we hypothesized that AhR-dependent regulation of endogenous miR-196a expression would promote cell survival and proliferation. Utilizing lung fibroblasts from AhR deficient (AhR{sup −/−}) and wild-type (AhR{sup +/+}) mice, we show that there is ligand-independent regulation of miRNA, including low miR-196a in AhR{sup −/−} cells. Validation by qRT-PCR revealed a significant decrease in basal expression of miR-196a in AhR{sup −/−} compared to AhR{sup +/+} cells. Exposure to AhR agonists benzo[a]pyrene (B[a]P) and FICZ as well as AhR antagonist CH-223191 decreased miR-196a expression in AhR{sup +/+} fibroblasts concomitant with decreased AhR protein levels. There was increased proliferation only in AhR{sup +/+} lung fibroblasts in response to serum, corresponding to a decrease in p27{sup KIP1} protein, a cyclin-dependent kinase inhibitor. Increasing the cellular levels of miR-196a had no effect on proliferation or expression of p27{sup KIP1} in AhR{sup −/−} fibroblasts but attenuated cigarette smoke-induced apoptosis. This study provides the first evidence that AhR expression is essential for the physiological regulation of cellular miRNA levels- including miR-196a. Future experiments designed to elucidate the functional relationship between the AhR and miR-196a may delineate additional novel ligand-independent roles for the AhR. - Highlights: • The AhR controls proliferation and apoptosis in lung cells. • The AhR regulates the

  13. RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR...

    Office of Scientific and Technical Information (OSTI)

    in prostate cancer Citation Details In-Document Search Title: RLIP76-dependent suppression of PI3KAKTBcl-2 pathway by miR-101 induces apoptosis in prostate cancer MicroRNA-101 ...

  14. Evidence for Stratospheric Downwelling Associated with High-Elevation Topography

    SciTech Connect (OSTI)

    Finkel, R

    2009-01-28

    The continued presence of elevated chlorine-36 in Sierra Nevada streams is commonly interpreted as residual nuclear fallout, but this prolonged storage contradicts accepted hydrologic models, which indicate much less short-term groundwater storage. Our hypothesis is that the chlorine-36 source is stratospheric downwelling during high-intensity storms by measuring beryllium-7 and -10, sodium-22, and chlorium-36 in precipitation, lake, and soil samples. These nuclides are produced in abundance in the stratosphere and, except for chlorine-36, did not occur as nuclear fallout. This project will either substantially change hydrologic models or reveal an unrecognized pathway for stratosphere-troposphere exchange. Either result will have substantial scientific impact. The test of the hypothesis is straightforward. If stratospheric downwelling occurs to the extent indicated by observed Sierran chlorine-36 levels, it should be detectable by elevated levels of beryllium-7 and -10, sodium-22, and chlorine-36 in storm precipitation. Samples will be collected from an established array of sampling locations. If elevated levels of these nuclides are not found, it would cast severe doubt on the hypothesis. In this case, Sierran hydrologic models will have to take into account high levels of long-term groundwater storage. If elevated levels of these nuclides are found in Sierran precipitation, it could only be from stratospheric input, both because nuclear fallout is no longer occurring and because beryllium-7 and -10 and sodium-22 are not produced by atmospheric nuclear tests.

  15. Performance of MOV Stem Lubricants at Elevated Temperatures

    SciTech Connect (OSTI)

    DeWall, Kevin George; Nitzel, Michael Everett; Watkins, John Clifford

    2001-07-01

    This paper documents the results of recent tests sponsored by the U. S. Nuclear Regulatory Commission (NRC) and performed by the Idaho National Engineering and Environmental Laboratory (INEEL). These tests address the effectiveness of the lubricant used on the threaded portion of the valve stem, where the stem nut turns on the stem. Recent testing indicates that an elevated temperature environment can lead to significant increases in the friction coefficient at the stem/stem-nut interface. Most valve actuator qualification tests are performed at room temperature. Similarly, in-service tests are run at ambient plant temperatures, usually 70 to 100°F. Since design conditions can lead to valve operating temperatures in the 200 to 300°F range, it is important to know whether a temperature-induced increase in friction at the stem/stem-nut interface will prevent the required operation of critical valves. Lubricant aging is another phenomenon that might have deleterious effects on the thrust output of a valve actuator. Laboratory experience and field experience both indicate that after long periods in elevated temperature environments, the lubricants may lose their lubrication qualities. The scope of the current test program includes testing of five different lubricants on four different valve stems. Pending completion of the testing, results of the tests conducted using two of the four stems are discussed. The test series included collection of baseline data at room temperature, single step temperature tests where the temperature of the test setup was elevated directly to 250°F, and step testing where the temperature was elevated in steps to 130, 190, and 250°F, then returned to 70°F. All greases tested showed evidence of physical change after elevated temperature tests. Except for one particular lubricant, all of the greases tested showed increased coefficients of friction at elevated temperatures. Numerous other preliminary conclusions are presented

  16. Material Activation Benchmark Experiments at the NuMI Hadron Absorber Hall in Fermilab

    SciTech Connect (OSTI)

    Matsumura, H.; Matsuda, N.; Kasugai, Y.; Toyoda, A.; Yashima, H.; Sekimoto, S.; Iwase, H.; Oishi, K.; Sakamoto, Y.; Nakashima, H.; Leveling, A.; Boehnlein, D.; Lauten, G.; Mokhov, N.; Vaziri, K.

    2014-06-15

    In our previous study, double and mirror symmetric activation peaks found for Al and Au arranged spatially on the back of the Hadron absorber of the NuMI beamline in Fermilab were considerably higher than those expected purely from muon-induced reactions. From material activation bench-mark experiments, we conclude that this activation is due to hadrons with energy greater than 3 GeV that had passed downstream through small gaps in the hadron absorber.

  17. Port Huron, MI Natural Gas Pipeline Imports From Canada (Million Cubic

    U.S. Energy Information Administration (EIA) Indexed Site

    Feet) Million Cubic Feet) Port Huron, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2016 262 278 16 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 08/31/2016 Next Release Date: 09/30/2016 Referring Pages: U.S.

  18. miR-21 modulates tumor outgrowth induced by human adipose tissue-derived mesenchymal stem cells in vivo

    SciTech Connect (OSTI)

    Shin, Keun Koo; Lee, Ae Lim; Kim, Jee Young; Medical Research Center for Ischemic Tissue Engineering, Pusan National University, Yangsan, Gyeongnam 626-870; BK21 Medical Science Education Center, School of Medicine, Pusan National University, Yangsan, Gyeongnam 626-870 ; Lee, Sun Young; Medical Research Center for Ischemic Tissue Engineering, Pusan National University, Yangsan, Gyeongnam 626-870 ; Bae, Yong Chan; Jung, Jin Sup

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer miR-21 modulates hADSC-induced increase of tumor growth. Black-Right-Pointing-Pointer The action is mostly mediated by the modulation of TGF-{beta} signaling. Black-Right-Pointing-Pointer Inhibition of miR-21 enhances the blood flow recovery in hindlimb ischemia. -- Abstract: Mesenchymal stem cells (MSCs) have generated a great deal of interest in clinical situations, due principally to their potential use in regenerative medicine and tissue engineering applications. However, the therapeutic application of MSCs remains limited, unless the favorable effects of MSCs on tumor growth in vivo, and the long-term safety of the clinical applications of MSCs, can be more thoroughly understood. In this study, we determined whether microRNAs can modulate MSC-induced tumor outgrowth in BALB/c nude mice. Overexpression of miR-21 in human adipose-derived stem cells (hADSCs) inhibited hADSC-induced tumor growth, and inhibition of miR-21 increased it. Downregulation of transforming growth factor beta receptor II (TGFBR2), but not of signal transducer and activator of transcription 3, in hADSCs showed effects similar to those of miR-21 overexpression. Downregulation of TGFBR2 and overexpression of miR21 decreased tumor vascularity. Inhibition of miR-21 and the addition of TGF-{beta} increased the levels of vascular endothelial growth factor and interleukin-6 in hADSCs. Transplantation of miR-21 inhibitor-transfected hADSCs increased blood flow recovery in a hind limb ischemia model of nude mice, compared with transplantation of control oligo-transfected cells. These findings indicate that MSCs might favor tumor growth in vivo. Thus, it is necessary to study the long-term safety of this technique before MSCs can be used as therapeutic tools in regenerative medicine and tissue engineering.

  19. Measurement of Pi-K Ratios from the NuMI Target

    SciTech Connect (OSTI)

    Seun, Sin Man; /Harvard U.

    2007-07-01

    Interactions of protons (p) with the NuMI (Neutrinos at the Main Injector) target are used to create the neutrino beam for the MINOS (Main Injector Neutrino Oscillation Search) Experiment. Using the MIPP (Main Injector Particle Production) experimental apparatus, the production of charged pions and kaons in p+NuMI interactions is studied. The data come from a sample of 2 x 10{sup 6} events obtained by MIPP using the 120 GeV/c proton beam from the Main Injector at Fermi National Accelerator Laboratory in Illinois, USA. Pions and kaons are identified by measurement in a Ring Imaging Cherenkov detector. Presented are measurements of {pi}{sup -}/{pi}{sup +}, K{sup -}/K{sup +}, {pi}{sup +}/K{sup +} and {pi}{sup -}/K{sup -} production ratios in the momentum range p{sub T} < 2 GeV/c transversely and 20 GeV/c < p{sub z} < 90 GeV/c longitudinally. Also provided are detailed comparisons of the MIPP NuMI data with the MIPP Thin Carbon data, the MIPP Monte Carlo simulation and the current MINOS models in the relevant momentum ranges.

  20. Tool 0.2: Value Brief Elevator Speech | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2: Value Brief Elevator Speech Tool 0.2: Value Brief Elevator Speech Tool 0.2: Value Brief Elevator Speech from the Introduction to Community Energy Strategic Planning. Tool 0.2: Value Brief Elevator Speech (44.96 KB) More Documents & Publications Guide to Community Energy Strategic Planning: Introduction CESP Tool 2.2: Stakeholder Invite

  1. EIA - Renewable Electricity State Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Alabama Renewable Electricity Profile 2010 Alabama profile Table 1. Summary Renewable Electric Power Industry Statistics (2010) Primary Renewable Energy Capacity Source Hydro Conventional Primary Renewable Energy Generation Source Hydro Conventional Capacity (megawatts) Value Percent of State Total Total Net Summer Electricity Capacity 32,417 100.0 Total Net Summer Renewable Capacity 3,855 11.9 Geothermal - - Hydro Conventional 3,272 10.1 Solar - - Wind - - Wood/Wood Waste 583 1.8 MSW/Landfill

  2. EIA - Renewable Electricity State Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Alaska Renewable Electricity Profile 2010 Alaska profile Table 1. Summary Renewable Electric Power Industry Statistics (2010) Primary Renewable Energy Capacity Source Hydro Conventional Primary Renewable Energy Generation Source Hydro Conventional Capacity (megawatts) Value Percent of State Total Total Net Summer Electricity Capacity 2,067 100.0 Total Net Summer Renewable Capacity 422 20.4 Geothermal - - Hydro Conventional 414 20.1 Solar - - Wind 7 0.4 Wood/Wood Waste - - MSW/Landfill Gas - -

  3. EIA - Renewable Electricity State Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Arizona Renewable Electricity Profile 2010 Arizona profile Table 1. Summary Renewable Electric Power Industry Statistics (2010) Primary Renewable Energy Capacity Source Hydro Conventional Primary Renewable Energy Generation Source Hydro Conventional Capacity (megawatts) Value Percent of State Total Total Net Summer Electricity Capacity 26,392 100.0 Total Net Summer Renewable Capacity 2,901 11.9 Geothermal - - Hydro Conventional 2,720 10.1 Solar 20 - Wind 128 - Wood/Wood Waste 583 1.8

  4. EIA - Renewable Electricity State Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Connecticut Renewable Electricity Profile 2010 Connecticut profile Table 1. Summary Renewable Electric Power Industry Statistics (2010) Primary Renewable Energy Capacity Source Municipal Solid Waste/Landfill Gas Primary Renewable Energy Generation Source Municipal Solid Waste/Landfill Gas Capacity (megawatts) Value Percent of State Total Total Net Summer Electricity Capacity 8,284 100.0 Total Net Summer Renewable Capacity 281 3.4 Geothermal - - Hydro Conventional 122 1.5 Solar - - Wind - -

  5. EIA - Renewable Electricity State Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Delaware Renewable Electricity Profile 2010 Delaware profile Table 1. Summary Renewable Electric Power Industry Statistics (2010) Primary Renewable Energy Capacity Source Municipal Solid Waste/Landfill Gas Primary Renewable Energy Generation Source Municipal Solid Waste/Landfill Gas Capacity (megawatts) Value Percent of State Total Total Net Summer Electricity Capacity 3,389 100.0 Total Net Summer Renewable Capacity 10 0.3 Geothermal - - Hydro Conventional - - Solar - - Wind 2 0.1 Wood/Wood

  6. EIA - Renewable Electricity State Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    District of Columbia Renewable Electricity Profile 2010 District of Columbia profile Table 1. Summary Renewable Electric Power Industry Statistics (2010) Primary Renewable Energy Capacity Source - Primary Renewable Energy Generation Source - Capacity (megawatts) Value Percent of State Total Total Net Summer Electricity Capacity 790 100.0 Total Net Summer Renewable Capacity - - Geothermal - - Hydro Conventional - - Solar - - Wind - - Wood/Wood Waste - - MSW/Landfill Gas - - Other Biomass - -

  7. EIA - Renewable Electricity State Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Georgia Renewable Electricity Profile 2010 Georgia profile Table 1. Summary Renewable Electric Power Industry Statistics (2010) Primary Renewable Energy Capacity Source Hydro Conventional Primary Renewable Energy Generation Source Hydro Conventional Capacity (megawatts) Value Percent of State Total Total Net Summer Electricity Capacity 36,636 100.0 Total Net Summer Renewable Capacity 2,689 7.3 Geothermal - - Hydro Conventional 2,052 5.6 Solar - - Wind - - Wood/Wood Waste 617 1.7 MSW/Landfill Gas

  8. EIA - Renewable Electricity State Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Kansas Renewable Electricity Profile 2010 Kansas profile Table 1. Summary Renewable Electric Power Industry Statistics (2010) Primary Renewable Energy Capacity Source Wind Primary Renewable Energy Generation Source Wind Capacity (megawatts) Value Percent of State Total Total Net Summer Electricity Capacity 12,543 100.0 Total Net Summer Renewable Capacity 1,082 8.6 Geothermal - - Hydro Conventional 3 * Solar - - Wind 1,072 8.5 Wood/Wood Waste - - MSW/Landfill Gas 7 0.1 Other Biomass - -

  9. EIA - Renewable Electricity State Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Louisiana Renewable Electricity Profile 2010 Louisiana profile Table 1. Summary Renewable Electric Power Industry Statistics (2010) Primary Renewable Energy Capacity Source Wood/Wood Waste Primary Renewable Energy Generation Source Wood/Wood Waste Capacity (megawatts) Value Percent of State Total Total Net Summer Electricity Capacity 26,744 100.0 Total Net Summer Renewable Capacity 517 1.9 Geothermal - - Hydro Conventional 192 0.7 Solar - - Wind - - Wood/Wood Waste 311 1.2 MSW/Landfill Gas - -

  10. EIA - Renewable Electricity State Profiles

    U.S. Energy Information Administration (EIA) Indexed Site

    Maryland Renewable Electricity Profile 2010 Maryland profile Table 1. Summary Renewable Electric Power Industry Statistics (2010) Primary Renewable Energy Capacity Source Hydro Conventional Primary Renewable Energy Generation Source Hydro Conventional Capacity (megawatts) Value Percent of State Total Total Net Summer Electricity Capacity 12,516 100.0 Total Net Summer Renewable Capacity 799 6.4 Geothermal - - Hydro Conventional 590 4.7 Solar 1 * Wind 70 0.6 Wood/Wood Waste 3 * MSW/Landfill Gas