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Sample records for mi az nm

  1. AZ Biodiesel | Open Energy Information

    Open Energy Info (EERE)

    AZ Biodiesel Jump to: navigation, search Name: AZ Biodiesel Place: Chandler, Arizona Zip: 85225 Product: AZ Biodiesel is a biodiesel producer that announced plans in July 2008 to...

  2. A-Z Link

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Use or Search the A-Z Index (this page) 2. Use search.lbl.gov powered by Google. 3. Use DS The Directory of both People and Organizations Frequently Requested from the A-Z Index...

  3. Category:Tucson, AZ | Open Energy Information

    Open Energy Info (EERE)

    VFullServiceRestaurant Tucson AZ Arizona Public Service Co.png SVFullServiceRestauran... 75 KB SVHospital Tucson AZ Arizona Public Service Co.png SVHospital Tucson AZ A... 88 KB...

  4. BASIN BLAN CO BLAN CO S OT ERO IGNAC IO-BLANCO AZ TEC BALLAR

    U.S. Energy Information Administration (EIA) Indexed Site

    AZ UT NM CO 1 2 Index Map for 2 Paradox-San Juan Panels 2001 Reserve Summary for All ... UPUT (Uinta-Piceance Basin and Utah). Map created June 2005; projection is UTM-13, ...

  5. AZ-101 Gamma Cart Operational Test Report

    SciTech Connect (OSTI)

    MENDOZA, R.E.

    2000-03-30

    Test Report documenting the successful completion of the Operational Test Procedure for the AZ-101 Gamma Carts. Gamma carts are in support of the AZ-101 Mixer Pump Test.

  6. City of Williams - AZ, Arizona (Utility Company) | Open Energy...

    Open Energy Info (EERE)

    Williams - AZ, Arizona (Utility Company) Jump to: navigation, search Name: City of Williams - AZ Place: Arizona Phone Number: 928-635-2667 or 928-635-4451 Website:...

  7. Sasabe, AZ Natural Gas Pipeline Exports to Mexico (Million Cubic...

    U.S. Energy Information Administration (EIA) Indexed Site

    Sasabe, AZ Natural Gas Pipeline Exports to Mexico (Million Cubic Feet) Sasabe, AZ Natural Gas Pipeline Exports to Mexico (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug ...

  8. RAPID/Roadmap/6-AZ-b | Open Energy Information

    Open Energy Info (EERE)

    Permitting Information Desktop Toolkit BETA About Bulk Transmission Geothermal Hydropower Solar Tools Contribute Contact Us Construction Storm Water Permit (6-AZ-b) The Clean Water...

  9. RAPID/Roadmap/8-AZ-a | Open Energy Information

    Open Energy Info (EERE)

    AZ-a < RAPID | Roadmap Jump to: navigation, search RAPID Regulatory and Permitting Information Desktop Toolkit BETA About Bulk Transmission Geothermal Hydropower Solar Tools...

  10. WM'02 Conference, February 24-28, 2002, Tucson, AZ

    Office of Scientific and Technical Information (OSTI)

    WM'02 Conference, February 24-28, 2002, Tucson, AZ 1 COMPOSITION OF INSOLUBLE RESIDUES GENERATED DURING SPENT FUEL DISSOLUTION Y. Pokhitonov, V. Aleksandruk, B. Bibichev, G....

  11. RAPID/Roadmap/8-AZ-c | Open Energy Information

    Open Energy Info (EERE)

    AZ-c < RAPID | Roadmap Jump to: navigation, search RAPID Regulatory and Permitting Information Desktop Toolkit BETA About Bulk Transmission Geothermal Hydropower Solar Tools...

  12. Measurement of the direct <mi>CP> -violating parameter <mi>Ami><mi>CP> in the decay <mi>D>+<mi>Kmi>-<mimi>+<mi>π>+

    SciTech Connect (OSTI)

    Abazov, V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Agnew, J. P.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Askew, A.; Atkins, S.; Augsten, K.; Avila, C.; Badaud, F.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, S.; Barberis, E.; Baringer, P.; Bartlett, J. F.; Bassler, U.; Bazterra, V.; Bean, A.; Begalli, M.; Bellantoni, L.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; Besançon, M.; Beuselinck, R.; Bhat, P. C.; Bhatia, S.; Bhatnagar, V.; Blazey, G.; Blessing, S.; Bloom, K.; Boehnlein, A.; Boline, D.; Boos, E. E.; Borissov, G.; Borysova, M.; Brandt, A.; Brandt, O.; Brock, R.; Bross, A.; Brown, D.; Bu, X. B.; Buehler, M.; Buescher, V.; Bunichev, V.; Burdin, S.; Buszello, C. P.; Camacho-Pérez, E.; Casey, B. C. K.; Castilla-Valdez, H.; Caughron, S.; Chakrabarti, S.; Chan, K. M.; Chandra, A.; Chapon, E.; Chen, G.; Cho, S. W.; Choi, S.; Choudhary, B.; Cihangir, S.; Claes, D.; Clutter, J.; Cooke, M.; Cooper, W. E.; Corcoran, M.; Couderc, F.; Cousinou, M. -C.; Cutts, D.; Das, A.; Davies, G.; de Jong, S. J.; De La Cruz-Burelo, E.; Déliot, F.; Demina, R.; Denisov, D.; Denisov, S. P.; Desai, S.; Deterre, C.; DeVaughan, K.; Diehl, H. T.; Diesburg, M.; Ding, P. F.; Dominguez, A.; Dubey, A.; Dudko, L. V.; Duperrin, A.; Dutt, S.; Eads, M.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Enari, Y.; Evans, H.; Evdokimov, V. N.; Fauré, A.; Feng, L.; Ferbel, T.; Fiedler, F.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Fortner, M.; Fox, H.; Fuess, S.; Garbincius, P. H.; Garcia-Bellido, A.; García-González, J. A.; Gavrilov, V.; Geng, W.; Gerber, C. E.; Gershtein, Y.; Ginther, G.; Gogota, O.; Golovanov, G.; Grannis, P. D.; Greder, S.; Greenlee, H.; Grenier, G.; Gris, Ph.; Grivaz, J. -F.; Grohsjean, A.; Grünendahl, S.; Grünewald, M. W.; Guillemin, T.; Gutierrez, G.; Gutierrez, P.; Haley, J.; Han, L.; Harder, K.; Harel, A.; Hauptman, J. M.; Hays, J.; Head, T.; Hebbeker, T.; Hedin, D.; Hegab, H.; Heinson, A. P.; Heintz, U.; Hensel, C.; Heredia-De La Cruz, I.; Herner, K.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hoang, T.; Hobbs, J. D.; Hoeneisen, B.; Hogan, J.; Hohlfeld, M.; Holzbauer, J. L.; Howley, I.; Hubacek, Z.; Hynek, V.; Iashvili, I.; Ilchenko, Y.; Illingworth, R.; Ito, A. S.; Jabeen, S.; Jaffré, M.; Jayasinghe, A.; Jeong, M. S.; Jesik, R.; Jiang, P.; Johns, K.; Johnson, E.; Johnson, M.; Jonckheere, A.; Jonsson, P.; Joshi, J.; Jung, A. W.; Juste, A.; Kajfasz, E.; Karmanov, D.; Katsanos, I.; Kaur, M.; Kehoe, R.; Kermiche, S.; Khalatyan, N.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. N.; Kiselevich, I.; Kohli, J. M.; Kozelov, A. V.; Kraus, J.; Kumar, A.; Kupco, A.; Kurča, T.; Kuzmin, V. A.; Lammers, S.; Lebrun, P.; Lee, H. S.; Lee, S. W.; Lee, W. M.; Lei, X.; Lellouch, J.; Li, D.; Li, H.; Li, L.; Li, Q. Z.; Lim, J. K.; Lincoln, D.; Linnemann, J.; Lipaev, V. V.; Lipton, R.; Liu, H.; Liu, Y.; Lobodenko, A.; Lokajicek, M.; Lopes de Sa, R.; Luna-Garcia, R.; Lyon, A. L.; Maciel, A. K. A.; Madar, R.; Magaña-Villalba, R.; Malik, S.; Malyshev, V. L.; Mansour, J.; Martínez-Ortega, J.; McCarthy, R.; McGivern, C. L.; Meijer, M. M.; Melnitchouk, A.; Menezes, D.; Mercadante, P. G.; Merkin, M.; Meyer, A.; Meyer, J.; Miconi, F.; Mondal, N. K.; Mulhearn, M.; Nagy, E.; Narain, M.; Nayyar, R.; Neal, H. A.; Negret, J. P.; Neustroev, P.; Nguyen, H. T.; Nunnemann, T.; Orduna, J.; Osman, N.; Osta, J.; Pal, A.; Parashar, N.; Parihar, V.; Park, S. K.; Partridge, R.; Parua, N.; Patwa, A.; Penning, B.; Perfilov, M.; Peters, Y.; Petridis, K.; Petrillo, G.; Pétroff, P.; Pleier, M. -A.; Podstavkov, V. M.; Popov, A. V.; Prewitt, M.; Price, D.; Prokopenko, N.; Qian, J.; Quadt, A.; Quinn, B.; Ratoff, P. N.; Razumov, I.; Ripp-Baudot, I.; Rizatdinova, F.; Rominsky, M.; Ross, A.; Royon, C.; Rubinov, P.; Ruchti, R.; Sajot, G.; Sánchez-Hernández, A.; Sanders, M. P.; Santos, A. S.; Savage, G.; Savitskyi, M.; Sawyer, L.; Scanlon, T.; Schamberger, R. D.; Scheglov, Y.; Schellman, H.; Schwanenberger, C.; Schwienhorst, R.; Sekaric, J.; Severini, H.; Shabalina, E.; Shary, V.; Shaw, S.; Shchukin, A. A.; Simak, V.; Skubic, P.; Slattery, P.; Smirnov, D.; Snow, G. R.; Snow, J.; Snyder, S.; Söldner-Rembold, S.; Sonnenschein, L.; Soustruznik, K.; Stark, J.; Stoyanova, D. A.; Strauss, M.; Suter, L.; Svoisky, P.; Titov, M.; Tokmenin, V. V.; Tsai, Y. -T.; Tsybychev, D.; Tuchming, B.; Tully, C.; Uvarov, L.; Uvarov, S.; Uzunyan, S.; Van Kooten, R.; van Leeuwen, W. M.; Varelas, N.; Varnes, E. W.; Vasilyev, I. A.; Verkheev, A. Y.; Vertogradov, L. S.; Verzocchi, M.; Vesterinen, M.; Vilanova, D.; Vokac, P.; Wahl, H. D.; Wang, M. H. L. S.; Warchol, J.; Watts, G.; Wayne, M.; Weichert, J.; Welty-Rieger, L.; Williams, M. R. J.; Wilson, G. W.; Wobisch, M.; Wood, D. R.; Wyatt, T. R.; Xie, Y.; Yamada, R.; Yang, S.; Yasuda, T.; Yatsunenko, Y. A.; Ye, W.; Ye, Z.; Yin, H.; Yip, K.; Youn, S. W.; Yu, J. M.; Zennamo, J.; Zhao, T. G.; Zhou, B.; Zhu, J.; Zielinski, M.; Zieminska, D.; Zivkovic, L.

    2014-12-01

    We measure the direct mi>Cmi>mi>P>-violating parameter mi>Ami>mi>Cmi>mi>Pmi> for the decay of the charged charm meson, mi>Dmi>+mi>Kmi>-mi>πmi>+mi>πmi>+ (and charge conjugate), using the full 10.4 mi>fbmi>-1 sample of mi>p>mi>p>¯ collisions at mi>smi>=1.96 mi>TeVmi> collected by the D0 detector at the Fermilab Tevatron collider. We extract the raw reconstructed charge asymmetry by fitting the invariant mass distributions for the sum and difference of charge-specific samples. This quantity is then corrected for detector-related asymmetries using data-driven methods and for possible physics asymmetries (from mi>B>mi>D

  13. EA-1797: Agua Caliente Solar Project in Yuma County, AZ | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    7: Agua Caliente Solar Project in Yuma County, AZ EA-1797: Agua Caliente Solar Project in Yuma County, AZ EA-1797: Final Environmental Assessment EA-1797

  14. 241-AZ Farm Annulus Extent of Condition Baseline Inspection

    SciTech Connect (OSTI)

    Engeman, Jason K.; Girardot, Crystal L.; Vazquez, Brandon J.

    2013-05-15

    This report provides the results of the comprehensive annulus visual inspection for tanks 241- AZ-101 and 241-AZ-102 performed in fiscal year 2013. The inspection established a baseline covering about 95 percent of the annulus floor for comparison with future inspections. Any changes in the condition are also included in this document.

  15. ANALYSIS RESULTS FOR BUILDING 241 702-AZ A TRAIN

    SciTech Connect (OSTI)

    DUNCAN JB; FRYE JM; COOKE CA; LI SW; BROCKMAN FJ

    2006-12-13

    This report presents the analyses results for three samples obtained under RPP-PLAN-28509, Sampling and Analysis Plan for Building 241 702-AZ A Train. The sampling and analysis was done in response to problem evaluation request number PER-2004-6139, 702-AZ Filter Rooms Need Radiological Cleanup Efforts.

  16. Nogales, AZ Natural Gas Pipeline Exports to Mexico (Million Cubic...

    U.S. Energy Information Administration (EIA) Indexed Site

    Million Cubic Feet) Nogales, AZ Natural Gas Pipeline Exports to Mexico (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2011 39 24 19 15 18 16 15 16 16 18 ...

  17. 2016 Spring Materials Research Society (Phoenix, AZ) - JCAP

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2016 Spring Materials Research Society (Phoenix, AZ) 2016 Spring Materials Research Society (Phoenix, AZ) Mon, Mar 28, 2016 6:00pm 18:00 Fri, Apr 1, 2016 7:00pm 19:00 Phoenix Convention Center 100 North 3rd Street Phoenix, Arizona 85004 United States Joel Ager, "Experimental Demonstrations of Solar-Driven Photoelectrochemical Water Splitting and Carbon Dioxide Reduction" John Gregoire, "High Throughput Materials Integration: Identifying Optimal Interfaces for Solar Fuels

  18. EA-1796: Sempra Mesquite Solar Energy Facility near Gillespie, AZ |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy 6: Sempra Mesquite Solar Energy Facility near Gillespie, AZ EA-1796: Sempra Mesquite Solar Energy Facility near Gillespie, AZ February 1, 2011 EA-1796: Final Environmental Assessment Loan Guarantee to Sempra Generation for Construction of the Mesquite Solar Energy Project; Maricopa County, Arizona February 22, 2011 EA-1796: Finding of No Significant Impact Loan Guarantee to Sempra Generation for Construction of the Mesquite Solar Energy Project; Maricopa

  19. BASIN BLAN CO BLAN CO S OT ERO IGNAC IO-BLANCO AZ TEC BALLAR

    U.S. Energy Information Administration (EIA) Indexed Site

    BOE Reserve Class No 2001 reserves 0.1 - 10 MBOE 10.1 - 100 MBOE 100.1 - 1,000 MBOE 1,000.1- 10,000 MBOE 10,000.1 - 100,000 MBOE > 100,000 MBOE Basin Outline AZ UT NM CO 1 2 Index Map for 2 Paradox-San Juan Panels 2001 Reserve Summary for All Paradox-San Juan Basin Fields Total Total Total Number Liquid Gas BOE of Reserves Reserves Reserves Fields (Mbbl) (MMcf) (Mbbl) Paradox-San Juan 250 174,193 20,653,622 3,616,464 Basin CO NM IGNAC IO-BLANCO IGNAC IO-BLANCO IGNAC IO-BLANCO IGNAC IO-BLANCO

  20. BASIN BLAN CO BLAN CO S OT ERO IGNAC IO-BLANCO AZ TEC BALLAR

    U.S. Energy Information Administration (EIA) Indexed Site

    Gas Reserve Class No 2001 gas reserves 0.1 - 10 MMCF 10.1 - 100 MMCF 100.1 - 1,000 MMCF 1,000.1- 10,000 MMCF 10,000.1 - 100,000 MMCF > 100,000 MMCF Basin Outline AZ UT NM CO 1 2 Index Map for 2 Paradox-San Juan Panels 2001 Reserve Summary for All Paradox-San Juan Basin Fields Total Total Total Number Liquid Gas BOE of Reserves Reserves Reserves Fields (Mbbl) (MMcf) (Mbbl) Paradox-San Juan 250 174,193 20,653,622 3,616,464 Basin CO NM IGNAC IO-BLANCO IGNAC IO-BLANCO IGNAC IO-BLANCO IGNAC

  1. BASIN BLAN CO BLAN CO S OT ERO IGNAC IO-BLANCO AZ TEC BALLAR

    U.S. Energy Information Administration (EIA) Indexed Site

    Liquids Reserve Class No 2001 liquids reserves 0.1 - 10 Mbbl 10.1 - 100 Mbbl 100.1 - 1,000 Mbbl 1,000.1- 10,000 Mbbl 10,000.1 - 100,000 Mbbl Basin Outline AZ UT NM CO 1 2 Index Map for 2 Paradox-San Juan Panels 2001 Reserve Summary for All Paradox-San Juan Basin Fields Total Total Total Number Liquid Gas BOE of Reserves Reserves Reserves Fields (Mbbl) (MMcf) (Mbbl) Paradox-San Juan 250 174,193 20,653,622 3,616,464 Basin CO NM IGNAC IO-BLANCO IGNAC IO-BLANCO IGNAC IO-BLANCO IGNAC IO-BLANCO IGNAC

  2. Santa Fe, NM 87506

    Office of Environmental Management (EM)

    July 31, 2014 Ms. Kimberly Davis Lebak Manager Los Alamos Field Office 3747 West Jemez Road, MS A316 Los Alamos, NM 87544 Mr. Pete Maggiore Assistant Manager for Environmental Operations 3747 West Jemez Road, MS A316 Los Alamos, NM 87544 Dear Ms. Lebak and Mr. Maggiore, I am pleased to enclose Recommendation 2014-02, unanimously approved by the Northern New Mexico Citizens' Advisory Board at its July 30 th meeting in Santa Fe. Please call Lee Bishop, DDFO or Menice Santistevan, Executive

  3. Mixer pump test plan for double shell tank AZ-101

    SciTech Connect (OSTI)

    STAEHR, T.W.

    1999-05-12

    Mixer pump systems have been chosen as the method for retrieval of tank wastes contained in double shell tanks at Hanford. This document describes the plan for testing and demonstrating the ability of two 300 hp mixer pumps to mobilize waste in tank AZ-101. The mixer pumps, equipment and instrumentation to monitor the test were installed by Project W-151.

  4. Nogales, AZ Liquefied Natural Gas Exports to Mexico (Million...

    U.S. Energy Information Administration (EIA) Indexed Site

    Million Cubic Feet) Nogales, AZ Liquefied Natural Gas Exports to Mexico (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2012 8.938 8.916 5.241 3.570 4.280 ...

  5. Santa Fe, NM 87506

    Office of Environmental Management (EM)

    Large Format Carbon Enhanced VRLA Battery Test Results EESAT 2009 Funded by the Energy Storage Systems Program of the U.S. Department Of Energy (DOE/ESS) through Sandia National Laboratories (SNL) October 4 - 7, 2009 Seattle, Washington Presented by: Tom Hund Sandia National Laboratories Albuquerque, NM (505) 844-8627 tdhund@sandia.gov *Sandia is a multi-program laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear

  6. Santa Fe, NM 87506

    Office of Environmental Management (EM)

    5 Ms. Christine Gelles, Acting Manager EM-LA Field Office 3747 West Jemez Road, MS A316 Los Alamos, NM 87544 Dear Ms. Gelles, I am pleased to enclose Recommendation 2015-03, unanimously approved by the Northern New Mexico Citizens' Advisory Board at its April 8, 2015 Combined Committee meeting in Pojoaque, New Mexico. Please call Lee Bishop, Co-DDFO, Michael Gardipe, Co-DDFO, or Menice Santistevan, Executive Director, if you have questions regarding this recommendation. We look forward to the

  7. 241-AZ Tank Farm Construction Extent of Condition Review for Tank Integrity

    SciTech Connect (OSTI)

    Barnes, Travis J.; Boomer, Kayle D.; Gunter, Jason R.; Venetz, Theodore J.

    2013-07-30

    This report provides the results of an extent of condition construction history review for tanks 241-AZ-101 and 241-AZ-102. The construction history of the 241-AZ tank farm has been reviewed to identify issues similar to those experienced during tank AY-102 construction. Those issues and others impacting integrity are discussed based on information found in available construction records, using tank AY-102 as the comparison benchmark. In the 241-AZ tank farm, the second DST farm constructed, both refractory quality and tank and liner fabrication were improved.

  8. DOE Zero Energy Ready Home Case Study: Mandalay Homes, Prescott Valley, AZ

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    | Department of Energy Mandalay Homes, Prescott Valley, AZ DOE Zero Energy Ready Home Case Study: Mandalay Homes, Prescott Valley, AZ DOE Zero Energy Ready Home Case Study: Mandalay Homes, Prescott Valley, AZ Case study of a DOE Zero Energy Ready home in northern AZ that achieved a HERS score of 48 without PV or 25 if 3.5 kW PV were added. The two-story, 2,469-ft2 production home has 2x4 walls filled with R-13 open-cell spray foam plus 1-in. rigid foam over plywood sheathing, a sealed R-20

  9. Safety analysis for tank 241-AZ-101 mixer pump process test

    SciTech Connect (OSTI)

    Milliken, N.J., Westinghouse Hanford

    1996-08-01

    This document establishes the safety envelope for Project W-151,the process test of two mixer pumps in AWF waste tank 241-AZ-101.

  10. VA VT CT RI MT WY CO ID UT OR NV CA AZ NM WA TN WV NC AR OK

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2 1 Locations of Smart Grid Demonstration and Large-Scale Energy Storage Projects NH 32 Awards Support Projects in 24 States 6 11 MA

  11. VA VT CT RI MT WY CO ID UT OR NV CA AZ NM WA TN WV NC AR OK

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2 1 Smart Grid Demonstration Project Locations NH MA 16 Awards Support Projects in 21 States

  12. VA VT CT RI MT WY CO ID UT OR NV CA AZ NM WA TN WV NC AR OK

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    7 2 1 Energy Storage Demonstration Project Locations NH 16 Awards Support Projects in 9 States MA

  13. VA VT CT RI MT WY CO ID UT OR NV CA AZ NM WA TN WV NC AR OK

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2 1 Locations of Smart Grid Demonstration and Large-Scale Energy Storage Projects NH 32 Awards Support Projects in 24 States 6 11 MA

  14. Nogales, AZ Liquefied Natural Gas Exports (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    (Million Cubic Feet) Nogales, AZ Liquefied Natural Gas Exports (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 12 16 2014 15 12 10 8 6 3 3 2 3 5 12 14 2015 12 9 9 9 8 5 3 2 3 7 15 22 2016 19 13 11 9 8 3 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 08/31/2016 Next Release Date: 09/30/2016 Referring Pages: U.S.

  15. Microsoft Word - Consolidated Final Transcript of CBS Tempe AZ

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    9 CONSENT-BASED SITING PUBLIC MEETING Phoenix Marriott Tempe at the Buttes 2000 W Westcourt Way Tempe, AZ 85282 June 23, 2016 FULL TRANSCRIPT Mr. Jim Hamilton. Good afternoon. And for those joining in a later time zone, good evening. Welcome to Tempe and to the sixth in a series of public meetings the Department is hosting on its Consent-Based Siting Program. Thank you all for being here today. My name is Jim Hamilton - I'm an advisor to the Department as part of their Consent-Based Siting Team

  16. EA-1797: Agua Caliente Solar Project in Yuma County, AZ | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy 7: Agua Caliente Solar Project in Yuma County, AZ EA-1797: Agua Caliente Solar Project in Yuma County, AZ November 1, 2010 EA-1797: Final Environmental Assessment Loan Guarantee for the Agua Caliente Solar Project in Yuma County, Arizona November 24, 2010 EA-1797: Finding of No Significant Impact Agua Caliente Solar Project in Yuma

  17. NM Invest | Open Energy Information

    Open Energy Info (EERE)

    Invest Jump to: navigation, search Name: NM Invest Place: Tyler, Texas Zip: 75703 Sector: Renewable Energy Product: Texas-based mezzanine investor to renewable projects, primarily...

  18. Real-time sub-<mi>>ngstrom...

    Office of Scientific and Technical Information (OSTI)

    Real-time sub-<mi>>ngstrom imaging of reversible and irreversible conformations in rhodium catalysts and graphene Kisielowski, Christian; Wang,...

  19. DOE - Office of Legacy Management -- Bayo Canyon NM Site - NM...

    Office of Legacy Management (LM)

    Land Surveying Preconstruction Meeting. August 13, 1982. NM.01-9 - Letter, R.L. Copper to G. Dawson. September 10, 1982. Required items for Purchase Contract 14501-01...

  20. Mi GmbH | Open Energy Information

    Open Energy Info (EERE)

    Mi GmbH Jump to: navigation, search Name: Mi GmbH Place: Switzerland Zip: CH-6340 Sector: Solar Product: Baar-based manufacturer and distributor of fruit juices. The firm is also...

  1. Influence of Aluminum Content on Grain Refinement and Strength of AZ31 Magnesium GTA Weld Metal

    SciTech Connect (OSTI)

    Babu, N. Kishore; Cross, Carl E.

    2012-06-28

    The goal is to characterize the effect of Al content on AZ31 weld metal, the grain size and strength, and examine role of Al on grain refinement. The approach is to systematically vary the aluminum content of AZ31 weld metal, Measure average grain size in weld metal, and Measure cross-weld tensile properties and hardness. Conclusions are that: (1) increased Al content in AZ31 weld metal results in grain refinement Reason: higher undercooling during solidification; (2) weld metal grain refinement resulted in increased strength & hardness Reason: grain boundary strengthening; and (3) weld metal strength can be raised to wrought base metal levels.

  2. 2015 Electrochemical Energy Summit at the 228th ECS Meeting (Phoenix, AZ)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    - JCAP 2015 Electrochemical Energy Summit at the 228th ECS Meeting (Phoenix, AZ) 2015 Electrochemical Energy Summit at the 228th ECS Meeting (Phoenix, AZ) Sun, Oct 11, 2015 4:30pm 16:30 Fri, Oct 16, 2015 5:30pm 17:30 Phoenix, AZ USA Harry Atwater, "Artificial Photosynthesis: Progress and Prospects" View presentation here Matthew McDowell, "New Advances in Stabilizing High Efficiency Semiconductors for Use in Solar Fuels Applications" View presentation here Ian Sharp,

  3. miRNAs in brain development

    SciTech Connect (OSTI)

    Petri, Rebecca; Malmevik, Josephine; Fasching, Liana; Åkerblom, Malin; Jakobsson, Johan

    2014-02-01

    MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of miRNAs are expressed and there is a growing body of evidence demonstrating that miRNAs are essential for brain development and neuronal function. Conditional knockout studies of the core components in the miRNA biogenesis pathway, such as Dicer and DGCR8, have demonstrated a crucial role for miRNAs during the development of the central nervous system. Furthermore, mice deleted for specific miRNAs and miRNA-clusters demonstrate diverse functional roles for different miRNAs during the development of different brain structures. miRNAs have been proposed to regulate cellular functions such as differentiation, proliferation and fate-determination of neural progenitors. In this review we summarise the findings from recent studies that highlight the importance of miRNAs in brain development with a focus on the mouse model. We also discuss the technical limitations of current miRNA studies that still limit our understanding of this family of non-coding RNAs and propose the use of novel and refined technologies that are needed in order to fully determine the impact of specific miRNAs in brain development. - Highlights: • miRNAs are essential for brain development and neuronal function. • KO of Dicer is embryonically lethal. • Conditional Dicer KO results in defective proliferation or increased apoptosis. • KO of individual miRNAs or miRNA families is necessary to determine function.

  4. Engineering task plan for the 241-AZ-101 waste tank color video camera system

    SciTech Connect (OSTI)

    Robinson, R.S., Westinghouse Hanford

    1996-07-01

    This Engineering Task Plan (ETP) is to be distributed to communicate the design basis of the 241-AZ-101 camera system and to define system requirements and associated responsibilities.

  5. File:USDA-CE-Production-GIFmaps-AZ.pdf | Open Energy Information

    Open Energy Info (EERE)

    AZ.pdf Jump to: navigation, search File File history File usage Arizona Ethanol Plant Locations Size of this preview: 776 600 pixels. Full resolution (1,650 1,275 pixels,...

  6. File:NREL-az-80m.pdf | Open Energy Information

    Open Energy Info (EERE)

    NREL-az-80m.pdf Jump to: navigation, search File File history File usage Arizona Annual Average Wind Speed at 80 Meters Size of this preview: 463 599 pixels. Other resolution:...

  7. DOE - Office of Legacy Management -- Monument Valley Mill Site - AZ 0-01

    Office of Legacy Management (LM)

    Monument Valley Mill Site - AZ 0-01 FUSRAP Considered Sites Site: Monument Valley Mill Site (AZ.0-01) Licensed to DOE for long-term custody and managed by the Office of Legacy Management Designated Name: Monument Valley, Arizona, Processing Site Alternate Name: Monument Valley Mill Site Uranium Mill in Monument Valley Location: Navajo Nation, northeastern Arizona Evaluation Year: Site Operations: Site Disposition: Uranium Mill Tailings Radiation Control Act (UMTRCA) Title I site Radioactive

  8. DOE - Office of Legacy Management -- Tuba City Mill Site - AZ 0-02

    Office of Legacy Management (LM)

    Mill Site - AZ 0-02 Site ID (CSD Index Number): AZ.0-02 Site Name: Tuba City Mill Site Site Summary: Site Link: Tuba City, Arizona, Disposal Site External Site Link: Alternate Name(s): Tuba City Mill Site Uranium Mill in Tuba City Alternate Name Documents: Location: Tuba City, Arizona, Navajo Nation Location Documents: Historical Operations (describe contaminants): Rare Metals Corporation and its successor, El Paso Natural Gas Company, operated a uranium mill at the site between 1956 and 1966.

  9. DOE - Office of Legacy Management -- Michigan Velsicol Chemical Corp - MI

    Office of Legacy Management (LM)

    03 Michigan Velsicol Chemical Corp - MI 03 FUSRAP Considered Sites Site: MICHIGAN [VELSICOL] CHEMICAL CORP. (MI.03 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Velsicol Chemical Corp. MI.03-1 Location: St. Louis , Michigan MI.03-2 Evaluation Year: Circa 1987 MI.03-3 Site Operations: Rare earth processing facility. MI.03-2 Site Disposition: Eliminated - No Authority - NRC survey MI.03-3 Radioactive Materials Handled: Yes Primary Radioactive

  10. DOE - Office of Legacy Management -- Star Cutter Corp - MI 15

    Office of Legacy Management (LM)

    Star Cutter Corp - MI 15 FUSRAP Considered Sites Site: STAR CUTTER CORP. (MI.15) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Farmington , Michigan MI.15-1 Evaluation Year: 1991 MI.15-2 Site Operations: Performed a one time uranium slug drilling operation test in 1956. MI.15-3 MI.15-1 Site Disposition: Eliminated - Potential for contamination considered remote based on limited scope and quantity of materials handled MI.15-2 Radioactive

  11. Oxide Film and Porosity Defects in Magnesium Alloy AZ91

    SciTech Connect (OSTI)

    Wang, Liang [Mississippi State University (MSU); Rhee, Hongjoo [Mississippi State University (MSU); Felicelli, Sergio D. [Mississippi State University (MSU); Sabau, Adrian S [ORNL; Berry, John T. [Mississippi State University (MSU)

    2009-01-01

    Porosity is a major concern in the production of light metal parts. This work aims to identify some of the mechanisms of microporosity formation in magnesium alloy AZ91. Microstructure analysis was performed on several samples obtained from gravity-poured ingots in graphite plate molds. Temperature data during cooling was acquired with type K thermocouples at 60 Hz at three locations of each casting. The microstructure of samples extracted from the regions of measured temperature was then characterized with optical metallography. Tensile tests and conventional four point bend tests were also conducted on specimens cut from the cast plates. Scanning electron microscopy was then used to observe the microstructure on the fracture surface of the specimens. The results of this study revealed the existence of abundant oxide film defects, similar to those observed in aluminum alloys. Remnants of oxide films were detected on some pore surfaces, and folded oxides were observed in fracture surfaces indicating the presence of double oxides entrained during pouring.

  12. Ultrasonic Spot Welding of AZ31B to Galvanized Mild Steel

    SciTech Connect (OSTI)

    Pan, Dr. Tsung-Yu; Franklin, Teresa; Pan, Professor Jwo; Brown, Elliot; Santella, Michael L

    2010-01-01

    Ultrasonic spot welds were made between sheets of 0.8-mm-thick hot-dip-galvanized mild steel and 1.6-mm-thick AZ31B-H24. Lap-shear strengths of 3.0-4.2 kN were achieved with weld times of 0.3-1.2 s. Failure to achieve strong bonding of joints where the Zn coating was removed from the steel surface indicate that Zn is essential to the bonding mechanism. Microstructure characterization and microchemical analysis indicated temperatures at the AZ31-steel interfaces reached at least 344 C in less than 0.3 s. The elevated temperature conditions promoted annealing of the AZ31-H24 metal and chemical reactions between it and the Zn coating.

  13. DOE - Office of Legacy Management -- Wolverine Tube Division - MI 05

    Office of Legacy Management (LM)

    Wolverine Tube Division - MI 05 FUSRAP Considered Sites Site: Wolverine Tube Division (MI.05) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Wolverine Tube Division of Calumet & Hecla Consolidated Copper Co. Star Tool Hermes Automotive Manufacturing Corporation MI.05-1 MI.05-2 Location: 1411 Central Avenue , Detroit , Michigan MI.05-3 Evaluation Year: 1990 MI.05-2 Site Operations: 1943 - Conducted research and development of methods for spinning

  14. DOE - Office of Legacy Management -- Adrian - MI 01

    Office of Legacy Management (LM)

    Adrian - MI 01 FUSRAP Considered Sites Adrian, MI Alternate Name(s): Bridgeport Brass Co. Special Metals Extrusion Plant Bridgeport Brass Company General Motors General Motors Company, Adrian MI.01-1 Location: 1450 East Beecher Street, Adrian, Michigan MI.01-3 Historical Operations: Performed uranium extrusion research and development and metal fabrication work for the AEC using uranium, thorium, and plutonium. MI.01-2 Eligibility Determination: Eligible MI.01-1 Radiological Survey(s):

  15. DOE - Office of Legacy Management -- Carboloy Co - MI 12

    Office of Legacy Management (LM)

    Carboloy Co - MI 12 FUSRAP Considered Sites Site: Carboloy Co. (MI.12 ) Eliminated from further consideration under FUSRAP - AEC licensed facility Designated Name: Not Designated Alternate Name: General Electric MI.12-1 Location: 11177 E. Eight Mile Road , Detroit , Michigan MI.12-1 MI.12-2 Evaluation Year: 1987-1991 MI.12-3 MI.12-4 MI.12-6 Site Operations: Turned-down the outer diameter of uranium metal slugs and conducted pilot plant scale operations for hot pressing uranium dioxide pellets

  16. 248-nm photolysis of tricarbonylnitrosylcobalt

    SciTech Connect (OSTI)

    Rayner, D.M.; Nazran, A.S.; Drouin, M.; Hackett, P.A.

    1986-06-19

    Laser-based time-resolved infrared absorption spectroscopy has been applied to the study of the 248-nm photolysis of the pseudo-nickel carbonyl, tricarbonylnitrosylcobalt, in the gas phase. Co(CO)/sub 3/NO dissociates by a series of sequential ligand eliminations to give predominantly CoCO. This species reacts back with parent Co(CO)/sub 3/NO with a gas kinetic rate constant of (6.4 +/- 0.6) x 10/sup -10/ cm/sup 3/ molecule/sup -1/ s/sup -1/ to form a binuclear species, (Co/sub 2/(CO)/sub 4/NO), of unknown structure. Added CO results in the formation of Co(CO)/sub 3/ and finally Co(CO)/sub 4/. The rate constant for the reactions of CO with Co(CO) is (6.2 +/- 0.6) x 10/sup -11/ cm/sup 3/ molecule/sup -1/ s/sup -1/ which is also a lower limit for the rates of reaction of CO with Co(CO)/sub 2/ and Co(CO)/sub 3/. This behavior shows marked similarity with recent work on the other carbonyls and begins to establish a general pattern for metal carbonyl photolysis.

  17. CESIUM REMOVAL FROM TANKS 241-AN-103 & 241-SX-105 & 241-AZ-101 & 241AZ-102 COMPOSITE FOR TESTING IN BENCH SCALE STEAM REFORMER

    SciTech Connect (OSTI)

    DUNCAN JB; HUBER HJ

    2011-04-21

    This report documents the preparation of three actual Hanford tank waste samples for shipment to the Savannah River National Laboratory (SRNL). Two of the samples were dissolved saltcakes from tank 241-AN-103 (hereafter AN-103) and tank 241-SX-105 (hereafter SX-105); one sample was a supernate composite from tanks 241-AZ-101 and 241-AZ-102 (hereafter AZ-101/102). The preparation of the samples was executed following the test plans LAB-PLAN-10-00006, Test Plan for the Preparation of Samples from Hanford Tanks 241-SX-105, 241-AN-103, 241-AN-107, and LAB-PLN-l0-00014, Test Plan for the Preparation of a Composite Sample from Hanford Tanks 241-AZ-101 and 241-AZ-102 for Steam Reformer Testing at the Savannah River National Laboratory. All procedural steps were recorded in laboratory notebook HNF-N-274 3. Sample breakdown diagrams for AN-103 and SX-105 are presented in Appendix A. The tank samples were prepared in support of a series of treatability studies of the Fluidized Bed Steam Reforming (FBSR) process using a Bench-Scale Reformer (BSR) at SRNL. Tests with simulants have shown that the FBSR mineralized waste form is comparable to low-activity waste glass with respect to environmental durability (WSRC-STI-2008-00268, Mineralization of Radioactive Wastes by Fluidized Bed Steam Reforming (FBSR): Comparisons to Vitreous Waste Forms and Pertinent Durability Testing). However, a rigorous assessment requires long-term performance data from FBSR product formed from actual Hanford tank waste. Washington River Protection Solutions, LLC (WRPS) has initiated a Waste Form Qualification Program (WP-5.2.1-2010-001, Fluidized Bed Steam Reformer Low-level Waste Form Qualification) to gather the data required to demonstrate that an adequate FBSR mineralized waste form can be produced. The documentation of the selection process of the three tank samples has been separately reported in RPP-48824, Sample Selection Process for Bench-Scale Steam Reforming Treatability Studies Using

  18. 241-AZ-101 Waste Tank Color Video Camera System Shop Acceptance Test Report

    SciTech Connect (OSTI)

    WERRY, S.M.

    2000-03-23

    This report includes shop acceptance test results. The test was performed prior to installation at tank AZ-101. Both the camera system and camera purge system were originally sought and procured as a part of initial waste retrieval project W-151.

  19. DOE - Office of Legacy Management -- Oliver Corp - MI 11

    Office of Legacy Management (LM)

    Oliver Corp - MI 11 FUSRAP Considered Sites Site: OLIVER CORP. (MI.11 ) Eliminated from further consideration under FUSRAP - Referred to NRC Designated Name: Not Designated Alternate Name: Behnke Warehousing Incorporated MI.11-1 Location: 433 East Michigan Avenue , Battle Creek , Michigan MI.11-1 Evaluation Year: 1986 MI.11-4 Site Operations: Conducted production scale briquetting of green salt and magnesium blend under AEC license Nos. SNM-591, SUB-579, and C-3725. MI.11-1 MI.11-3 Site

  20. The NuMI Neutrino Beam

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Adamson, P.; Anderson, K.; Andrews, M.; Andrews, R.; Anghel, I.; Augustine, D.; Aurisano, A.; Avvakumov, S.; Ayres, D. S.; Baller, B.; et al

    2015-10-20

    Our paper describes the hardware and operations of the Neutrinos at the Main Injector (NuMI) beam at Fermilab. It elaborates on the design considerations for the beam as a whole and for individual elements. The most important part of our design details pertaining to individual components is described. Beam monitoring systems and procedures, including the tuning and alignment of the beam and NuMI long-term performance, are also discussed.

  1. DOE - Office of Legacy Management -- Detrex Corp - MI 10

    Office of Legacy Management (LM)

    Detrex Corp - MI 10 FUSRAP Considered Sites Site: Detrex Corp. (MI.10 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Detroit , Michigan MI.10-1 Evaluation Year: 1987 MI.10-2 Site Operations: Conducted experimental runs relative to pickling/degreasing of one handful of uranium turnings MI.10-1 Site Disposition: Eliminated - Potential for contamination considered remote due to small quantity of material handled - There is no

  2. DOE Zero Energy Ready Home Case Study: Mandalay Homes, Phoenix, AZ, Affordable

    Broader source: Energy.gov [DOE]

    Case study of a DOE Zero Energy Ready Home in Phoenix, AZ, that scored HERS 58 without PV or HERS 38 with PV. This 1,700-square-foot affordable home has R-21 framed walls, a sealed closed-cell spray foamed attic, an air-source heat pump with forced air, and a solar combo system that provides PV, hot water, and space heating.

  3. Best Practices Case Study: John Wesley Miller Companies - Armory Park Del Sol, Tucson, AZ

    SciTech Connect (OSTI)

    2009-10-01

    Case study of John Wesley Miller Companies, who built two net zero energy homes plus 97 other solar homes in Tucson, AZ. Masonry block walls with rigid foam exterior sheathing, rigid foam over the roof deck plus R-38 in the attic, ducts in conditioned space, 4.2 kW and 5.7 kW photovoltaics and solar water heating yielded HERS scores of 0 on the two homes.

  4. Test plan: Laboratory-scale testing of the first core sample from Tank 102-AZ

    SciTech Connect (OSTI)

    Morrey, E.V.

    1996-03-01

    The overall objectives of the Radioactive Process/Product Laboratory Testing (RPPLT), WBS 1.2.2.05.05, are to confirm that simulated HWVP feed and glass are representative of actual radioactive HWVP feed and glass and to provide radioactive leaching and glass composition data to WFQ. This study will provide data from one additional NCAW core sample (102-AZ Core 1) for these purposes.

  5. DOE Zero Energy Ready Home Case Study 2013: Mandalay Homes, Phoenix, AZ, Affordable, Gordon Estates

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Mandalay Homes Phoenix, AZ BUILDING TECHNOLOGIES OFFICE The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR for Homes Version 3 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies are designed in to give you superior

  6. DOE - Office of Legacy Management -- Naval Ordnance Plant - MI...

    Office of Legacy Management (LM)

    Eliminated from further consideration under FUSRAP - Referred to DoD for action Designated ... MI.0-03-1 Site Disposition: Eliminated - No Authority - Referred to DoD MI.0-03-1 ...

  7. miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor

    SciTech Connect (OSTI)

    Park, Jong-Kook; Henry, Jon C.; Jiang, Jinmai; Esau, Christine; Gusev, Yuriy; Lerner, Megan R.; Postier, Russell G.; Brackett, Daniel J.; Schmittgen, Thomas D.

    2011-03-25

    Research highlights: {yields} The expression of miR-132 and miR-212 are significantly increased in pancreatic cancer. {yields} miR-132 and miR-212 target the tumor suppressor pRb, resulting in enhanced proliferation. {yields} miR-132 and miR-212 expression is increased by a {beta}2 adrenergic receptor agonist, suggesting a novel mechanism for pancreatic cancer progression. -- Abstract: Numerous microRNAs (miRNAs) are reported as differentially expressed in cancer, however the consequence of miRNA deregulation in cancer is unknown for many miRNAs. We report that two miRNAs located on chromosome 17p13, miR-132 and miR-212, are over-expressed in pancreatic adenocarcinoma (PDAC) tissues. Both miRNAs are predicted to target the retinoblastoma tumor suppressor, Rb1. Validation of this interaction was confirmed by luciferase reporter assay and western blot in a pancreatic cancer cell line transfected with pre-miR-212 and pre-miR-132 oligos. Cell proliferation was enhanced in Panc-1 cells transfected with pre-miR-132/-212 oligos. Conversely, antisense oligos to miR-132/-212 reduced cell proliferation and caused a G{sub 2}/M cell cycle arrest. The mRNA of a number of E2F transcriptional targets were increased in cells over expressing miR-132/-212. Exposing Panc-1 cells to the {beta}2 adrenergic receptor agonist, terbutaline, increased the miR-132 and miR-212 expression by 2- to 4-fold. We report that over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells and that the increase in cell proliferation from over-expression of these miRNAs is likely due to increased expression of several E2F target genes. The {beta}2 adrenergic pathway may play an important role in this novel mechanism.

  8. “Nodal Gap” induced by the incommensurate diagonal spin density modulation in underdoped high- <mi>Tmi>c> superconductors

    SciTech Connect (OSTI)

    Zhou, Tao; Gao, Yi; Zhu, Jian -Xin

    2015-03-07

    Recently it was revealed that the whole Fermi surface is fully gapped for several families of underdoped cuprates. The existence of the finite energy gap along the <mi>d>-wave nodal lines (nodal gap) contrasts the common understanding of the <mi>d>-wave pairing symmetry, which challenges the present theories for the high-<mi>Tmi><mi>c>superconductors. Here we propose that the incommensurate diagonal spin-density-wave order can account for the above experimental observation. The Fermi surface and the local density of states are also studied. Our results are in good agreement with many important experiments in high-<mi>Tmi><mi>c>superconductors.

  9. Characterization of function and regulation of miR-24-1 and miR-31

    SciTech Connect (OSTI)

    Sun Fenyong; Wang Jiayi; Pan Qiuhui; Yu Yongchun; Zhang Yue; Wan Yang; Wang Ju; Li Xiaoyan; Hong An

    2009-03-13

    To date, numerous microRNAs (miRNAs) have been discovered. However, the function of these miRNAs is largely unknown. While our knowledge of miRNA post-transcriptional processing has greatly expanded in recent years, we have a limited understanding of the regulation and transcription of miRNA genes. In this study, we characterized two BMP-2 upregulated miRNAs, miR-24-1 and miR-31, in mesenchymal stem cells and showed their opposing function in controlling cellular proliferation, and adipogenesis. Furthermore, we are the first to identify and characterize mouse intronic miR-23b{approx}27b{approx}24-1 and intergenic miR-31 genes. Moreover, we found that pri-miR-23b, pri-miR-27b, and pri-miR-24-1 are transcribed independently and their expression profiles are unique when cells are treated with BMP-2, even though they are located closely together.

  10. FAPAC-NM Executive Board | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Our Locations Albuquerque Complex Federal Asian Pacific American Council - New Mexico Chapter Albuquerque, NM FAPAC-NM Executive Board FAPAC-NM Executive Board "Promoting...

  11. Evaluation of Multiplexed 16S rRNA Microbial Population Surveys Using Illumina MiSeq Platform (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    ScienceCinema (OSTI)

    Tremblay, Julien [DOE JGI

    2013-01-25

    Julien Tremblay from DOE JGI presents "Evaluation of Multiplexed 16S rRNA Microbial Population Surveys Using Illumina MiSeq Platorm" at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.

  12. DOE Zero Ready Home Case Study: Mandalay Homes, Pronghorn Ranch,Prescott Valley, AZ

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Homes Pronghorn Ranch Prescott Valley, AZ DOE ZERO ENERGY READY HOME(tm) The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR Certified Homes Version 3.0 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies are designed in

  13. DOE - Office of Legacy Management -- Dow Chemical Co - Midland - MI 06

    Office of Legacy Management (LM)

    Midland - MI 06 FUSRAP Considered Sites Site: Dow Chemical Co. - Midland (MI.06 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Midland , Michigan MI.06-1 Evaluation Year: Circa 1987 MI.06-2 Site Operations: Conducted development work for production of magnesium-thorium alloys. MI.06-1 Site Disposition: Eliminated - AEC licensed site MI.06-1 MI.06-2 Radioactive Materials Handled: Yes Primary Radioactive Materials Handled:

  14. Project W-151 Tank 101-AZ Waste Retrieval System Year 2000 Compliance Assessment Project Plan

    SciTech Connect (OSTI)

    BUSSELL, J.H.

    1999-08-02

    This assessment describes the potential Year 2000 (Y2K) problems and describes the methods for achieving Y2K compliance for Project W-151, Tank 101-AZ Waste Retrieval System. The purpose of this assessment is to give an overview of the project. This document will not be updated and any dates contained in this document are estimates and may change. Two mixer pumps and instrumentation have been or are planned to be installed in waste tank 101-AZ to demonstrate solids mobilization. The information and experience gained during this process test will provide data for comparison with sludge mobilization prediction models and provide indication of the effects of mixer pump operation on an Aging Waste Facility tank. A limited description of system dates, functions, interfaces, potential Y2K problems, and date resolutions is presented. The project is presently on hold, and definitive design and procurement have been completed. This assessment will describe the methods, protocols, and practices to ensure that equipment and systems do not have Y2K problems.

  15. Characterization of fold defects in AZ91D and AE42 magnesium alloy permanent mold castings

    SciTech Connect (OSTI)

    Bichler, L. [Centre for Near-net-shape Processing of Materials, Ryerson University, 101 Gerrard St. E., Toronto, M5B 2K3 (Canada); Ravindran, C., E-mail: rravindr@ryerson.ca [Centre for Near-net-shape Processing of Materials, Ryerson University, 101 Gerrard St. E., Toronto, M5B 2K3 (Canada)

    2010-03-15

    Casting premium-quality magnesium alloy components for aerospace and automotive applications poses unique challenges. Magnesium alloys are known to freeze rapidly prior to filling a casting cavity, resulting in misruns and cold shuts. In addition, melt oxidation, solute segregation and turbulent metal flow during casting contribute to the formation of fold defects. In this research, formation of fold defects in AZ91D and AE42 magnesium alloys cast via the permanent mold casting process was investigated. Computer simulations of the casting process predicted the development of a turbulent metal flow in a critical casting region with abrupt geometrical transitions. SEM and light optical microscopy examinations revealed the presence of folds in this region for both alloys. However, each alloy exhibited a unique mechanism responsible for fold formation. In the AZ91D alloy, melt oxidation and velocity gradients in the critical casting region prevented fusion of merging metal front streams. In the AE42 alloy, limited solubility of rare-earth intermetallic compounds in the {alpha}-Mg phase resulted in segregation of Al{sub 2}RE particles at the leading edge of a metal front and created microstructural inhomogeneity across the fold.

  16. CHARACTERIZATION AND FORMABILITY OF CONTINUOUS-CAST AZ31B MAGNESIUM ALLOY SHEETS

    SciTech Connect (OSTI)

    Rohatgi, Aashish; Herling, Darrell R.; Nyberg, Eric A.

    2009-09-24

    The goal of this work is to understand the inter-relationship between the initial properties of continuous-cast magnesium alloy (AZ31B) sheets and their subsequent formability and post-formed mechanical performance for use in cost-effective, lightweight, automotive body panels. As-received sheets, provided by the Automotive Metals Division (AMD-602) team, were characterized by surface roughness measurements using mechanical profilometry. The arithmetic mean deviation of profile (Ra) and the maximum two-point height of profile (Ry) of the as-received sheets ranged from ~0.2-2 ?m and ~2-15 ?m, respectively. Several commercial lubricants were evaluated by thermal analysis and the liquid phase of the lubricants was found to evaporate/decompose upon heating leaving behind a solid residue upon heating to temperatures exceeding ~125-150C. Elevated temperature bending-under-tension (BUT) friction tests were conducted at 350C and the coefficient-of-friction values ranged from a minimum of ~0.1 (for tungsten disulfide lubricant) to ~0.7 when no lubricant was used. These results, in conjunction with those from the forming trials conducted by the AMD-602 team, will be eventually used to determine the role of sheet-die friction in determining the formability of AZ31B sheets.

  17. SAFETY ANALYSIS FOR TANK 241-AZ-101 MIXER PUMP PROCESS TEST

    SciTech Connect (OSTI)

    HAMMOND DM; HARRIS JP; MOUETTE P

    1997-06-09

    This document contains the completed safety analysis which establishes the safety envelope for performing the mixer pump process test in Tank 241-AZ-101. This process test is described in TF-210-OTP-001. All equipment necessary for the mixer pump test has been installed by Project W-151. The purpose of this document is to describe and analyze the mixer pump test for Aging Waste Facility (AWF) Tank 241-AZ-101 and to address the 'yes/maybe' responses marked for evaluation questions identified in Unreviewed Safety Question Evaluation (USQE) TF-94-0266. The scope of this document is limited to the performance of the mixer pump test for Tank 241-AZ-101. Unreviewed Safety Question Determination (USQD) TF-96-0018 verified that the installation of two mixer pumps into Tank 241-AZ-101 was within the current Tank Waste Remediation System (TWRS) Authorization Basis. USQDs TF-96-0461, TF-96-0448, and TF-96-0805 verified that the installation of the in-tank video camera, thermocouples, and Ultrasonic Interface Level Analyzer (URSILLA), respectively, were within the current TWRS Authorization Basis. USQD TF-96-1041 verified that the checkout testing of the installed equipment was within the current TWRS Authorization Basis. Installation of the pumps and equipment has been completed. An evaluation of safety considerations associated with operation of the mixer pumps for the mixer pump test is provided in this document. This document augments the existing AWF authorization basis as defined in the Interim Safety Basis (Stahl 1997), and as such, will use the existing Interim Operational Safety Requirements (IOSRs) of Heubach 1996 to adequately control the mixer pump test. The hazard and accident analysis is limited to the scope and impact of the mixer pump test, and therefore does not address hazards already addressed by the current AWF authorization basis. This document does not evaluate removal of the mixer pumps. Safety considerations for removal of the pumps will be addressed by

  18. Radiation Tolerance of 65nm CMOS Transistors

    SciTech Connect (OSTI)

    Krohn, M.; Bentele, B.; Christian, D. C.; Cumalat, J. P.; Deptuch, G.; Fahim, F.; Hoff, J.; Shenai, A.; Wagner, S. R.

    2015-12-11

    We report on the effects of ionizing radiation on 65 nm CMOS transistors held at approximately -20C during irradiation. The pattern of damage observed after a total dose of 1 Grad is similar to damage reported in room temperature exposures, but we observe less damage than was observed at room temperature.

  19. Radiation Tolerance of 65nm CMOS Transistors

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Krohn, M.; Bentele, B.; Christian, D. C.; Cumalat, J. P.; Deptuch, G.; Fahim, F.; Hoff, J.; Shenai, A.; Wagner, S. R.

    2015-12-11

    We report on the effects of ionizing radiation on 65 nm CMOS transistors held at approximately -20°C during irradiation. The pattern of damage observed after a total dose of 1 Grad is similar to damage reported in room temperature exposures, but we observe less damage than was observed at room temperature.

  20. DOE - Office of Legacy Management -- General Motors Co - Flint - MI 07

    Office of Legacy Management (LM)

    Motors Co - Flint - MI 07 FUSRAP Considered Sites Site: GENERAL MOTORS CO. (MI.07 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: A.C. Spark Plug Dort Highway Plant MI.07-1 MI.07-2 Location: Flint , Michigan MI.07-1 Evaluation Year: 1987 MI.07-3 Site Operations: Processed thorium oxide, uranium oxide, and beryllium oxide into crucibles for the Chicago Area. MI.07-3 MI.07-4 MI.07-5 Site Disposition: Eliminated - Potential for contamination

  1. Pump Jet Mixing and Pipeline Transfer Assessment for High-Activity Radioactive Wastes in Hanford Tank 241-AZ-102

    SciTech Connect (OSTI)

    Onishi, Yasuo; Recknagle, Kurtis P.; Wells, Beric E.

    2000-08-09

    This report evaluates how two 300-hp mixer pumps would mix solid and liquid radioactive wastes stored in Hanford double-shell Tank 241-AZ-102. It also assesses and confirms the adequacy of a 3-inch pipeline to transfer the resulting mixed waste slurry to the AP Tank Farm and ultimately to a planned waste treatment/vitrification plant on the Hanford Site.

  2. MINOS Experiment and NuMI Beam Home Page

    Broader source: All U.S. Department of Energy (DOE) Office Webpages

    NuMI-MINOS Neutrino Logo NuMI Beamline and MINOS Experiment Neutrino Logo The MINOS Experiment and NuMI Beamline Fermilab Logo MINOS Experiment Links ◊ MINOS for the Public ◊ Scientific Results ◊ MINOS at Work ◊ NuMI at Work ◊ MINOS+ Experiment Fermilab Neutrino Links ◊ Neutrino FAQ ◊ MINOS Underground Areas at Fermilab ◊ PPD Intensity Frontier Dept Back to - - - ◊ Fermilab at Work ◊ Fermilab Home the MINOS Far Detector in the Soudan Mine MINOS collaborators assembling the

  3. Magnetocrystalline anisotropy in <mi>UMn>2<mi>Ge>2 and related Mn-based actinide ferromagnets

    SciTech Connect (OSTI)

    Parker, David S.; Ghimire, Nirmal; Singleton, John; Thompson, J. D.; Bauer, Eric D.; Baumbach, Ryan; Mandrus, David; Li, Ling; Singh, David J.

    2015-05-04

    We present magnetization isotherms in pulsed magnetic fields up to 62 Tesla, supported by first principles calculations, demonstrating a huge uniaxial magnetocrystalline anisotropy energy - approximately 20 MJ/m3 - in <mi>UMn>2<mi>Ge>2. This large anisotropy results from the extremely strong spin-orbit coupling affecting the uranium 5 f electrons, which in the calculations exhibit a substantial orbital moment exceeding 2 μB. Finally, we also find from theoretical calculations that a number of isostructural Mn-actinide compounds are expected to have similarly large anisotropy.

  4. ,"Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf...

    U.S. Energy Information Administration (EIA) Indexed Site

    ,"Worksheet Name","Description"," Of Series","Frequency","Latest Data for" ,"Data 1","Detroit, MI Natural Gas Pipeline Imports From Canada (MMcf)",1,"Annual",2014 ,"Release...

  5. Laser beam welding of AZ31B-H24 magnesium alloy.

    SciTech Connect (OSTI)

    Leong, K. H.

    1998-09-29

    The laser beam weldability of AZ31B magnesium alloy was examined with high power CW CO{sub 2} and pulsed Nd:YAG lasers. The low viscosity and surface tension of the melt pool make magnesium more difficult to weld than steel. Welding parameters necessary to obtain good welds were determined for both CW CO{sub 2} and pulsed Nd:YAG lasers. The weldability of the magnesium alloy was significantly better with the Nd:YAG laser. The cause of this improvement was attributed to the higher absorption of the Nd:YAG beam. A lower threshold beam irradiance was required for welding, and a more stable weldpool was obtained.

  6. Evaluation of cracking in the 241-AZ tank farm ventilation line at the Hanford Site

    SciTech Connect (OSTI)

    ANANTATMULA, R.P.

    1999-10-20

    In the period from April to October of 1988, a series of welding operations on the outside of the AZ Tank Farm ventilation line piping at the Hanford Site produced unexpected and repeated cracking of the austenitic stainless steel base metal and of a seam weld in the pipe. The ventilation line is fabricated from type 304L stainless steel pipe of 24 inch diameter and 0.25 inch wall thickness. The pipe was wrapped in polyethylene bubble wrap and buried approximately 12 feet below grade. Except for the time period between 1980 and 1987, impressed current cathodic protection has been applied to the pipe since its installation in 1974. The paper describes the history of the cracking of the pipe, the probable cracking mechanisms, and the recommended future action for repair/replacement of the pipe.

  7. Archaeological studies at Drill Hole U20az Pahute Mesa, Nye county, Nevada. [Contains bibliography

    SciTech Connect (OSTI)

    Simmons, A.H.; Hemphill, M.L.; Henton, G.H.; Lockett, C.L.; Nials, F.L.; Pippin, L.C.; Walsh, L.

    1991-07-01

    During the summer of 1987, the Quaternary Sciences Center (formerly Social Science Center) of the Desert Research Institute (DRI), University of Nevada System, conducted data recovery investigations at five archaeological sites located near Drill Hole U20az on the Nevada Test Site in southern Nevada. These sites were among 12 recorded earlier during an archaeological survey of the drill hole conducted as part of the environmental compliance activities of the Department of Energy (DOE). The five sites discussed in this report were considered eligible for the National Register of Historic Places and were in danger of being adversely impacted by construction activities or by effects of the proposed underground nuclear test. Avoidance of these sites was not a feasible alternative; thus DRI undertook a data recovery program to mitigate expected adverse impacts. DRI's research plan included controlled surface collections and excavation of the five sites in question, and had the concurrence of the Nevada Division of Historic Preservation and Archaeology and the Advisory Council of Historic Preservation. Of the five sites investigated, the largest and most complex, 26Ny5207, consists of at least three discrete artifact concentrations. Sites 26Ny5211 and 26Ny5215, both yielded considerable assemblages. Site 26Ny5206 is very small and probably is linked to 26Ny5207. Site 26Ny5205 contained a limited artifact assemblage. All of the sites were open-air occurrences, and, with one exception contained no or limited subsurface cultural deposits. Only two radiocarbon dates were obtained, both from 26Ny5207 and both relatively recent. While the investigations reported in the volume mitigate most of the adverse impacts from DOE activities at Drill Hole U20az, significant archaeological sites may still exist in the general vicinity. Should the DOE conduct further activities in the region, additional cultural resource investigations may be required. 132 refs., 71 figs., 44 tabs.

  8. Photo Album Of FAPAC - NM Activities | National Nuclear Security...

    National Nuclear Security Administration (NNSA)

    Our Locations Albuquerque Complex Federal Asian Pacific American Council - New Mexico Chapter Albuquerque, NM Photo Album Of FAPAC - NM Activities Photo Album Of FAPAC -...

  9. Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells

    SciTech Connect (OSTI)

    Vrba, Lukas; Jensen, Taylor J.; Garbe, James C.; Heimark, Ronald L.; Cress, Anne E.; Dickinson, Sally; Stampfer, Martha R.; Futscher, Bernard W.

    2009-12-23

    BACKGROUND: The microRNA-200 family participates in the maintenance of an epithelial phenotype and loss of its expression can result in epithelial to mesenchymal transition (EMT). Furthermore, the loss of expression of miR-200 family members is linked to an aggressive cancer phenotype. Regulation of the miR-200 family expression in normal and cancer cells is not fully understood. METHODOLOGY/ PRINCIPAL FINDINGS: Epigenetic mechanisms participate in the control of miR-200c and miR-141 expression in both normal and cancer cells. A CpG island near the predicted mir-200c/mir-141 transcription start site shows a striking correlation between miR-200c and miR-141 expression and DNA methylation in both normal and cancer cells, as determined by MassARRAY technology. The CpG island is unmethylated in human miR-200/miR-141 expressing epithelial cells and in miR-200c/miR-141 positive tumor cells. The CpG island is heavily methylated in human miR-200c/miR-141 negative fibroblasts and miR-200c/miR-141 negative tumor cells. Mouse cells show a similar inverse correlation between DNA methylation and miR-200c expression. Enrichment of permissive histone modifications, H3 acetylation and H3K4 trimethylation, is seen in normal miR-200c/miR-141-positive epithelial cells, as determined by chromatin immunoprecipitation coupled to real-time PCR. In contrast, repressive H3K9 dimethylation marks are present in normal miR-200c/miR-141-negative fibroblasts and miR-200c/miR-141 negative cancer cells and the permissive histone modifications are absent. The epigenetic modifier drug, 5-aza-2'-deoxycytidine, reactivates miR-200c/miR-141 expression showing that epigenetic mechanisms play a functional role in their transcriptional control. CONCLUSIONS/ SIGNIFICANCE: We report that DNA methylation plays a role in the normal cell type-specific expression of miR-200c and miR-141 and this role appears evolutionarily conserved, since similar results were obtained in mouse. Aberrant DNA methylation of the

  10. miR-92a family and their target genes in tumorigenesis and metastasis

    SciTech Connect (OSTI)

    Li, Molin; Guan, Xingfang; Sun, Yuqiang; Mi, Jun; Shu, Xiaohong; Liu, Fang; Li, Chuangang

    2014-04-15

    The miR-92a family, including miR-25, miR-92a-1, miR-92a-2 and miR-363, arises from three different paralog clusters miR-17-92, miR-106a-363, and miR-106b-25 that are highly conservative in the process of evolution, and it was thought as a group of microRNAs (miRNAs) correlated with endothelial cells. Aberrant expression of miR-92a family was detected in multiple cancers, and the disturbance of miR-92a family was related with tumorigenesis and tumor development. In this review, the progress on the relationship between miR-92a family and their target genes and malignant tumors will be summarized. - Highlights: Aberrant expression of miR-92a, miR-25 and miR-363 can be observed in many kinds of malignant tumors. The expression of miR-92a family is regulated by LOH, epigenetic alteration, transcriptional factors such as SP1, MYC, E2F, wild-type p53 etc. Roles of miR-92a family in tumorigenesis and development: promoting cell proliferation, invasion and metastasis, inhibiting cell apoptosis.

  11. THE SPECTRUM OF THORIUM FROM 250 nm TO 5500 nm: RITZ WAVELENGTHS AND OPTIMIZED ENERGY LEVELS

    SciTech Connect (OSTI)

    Redman, Stephen L.; Nave, Gillian; Sansonetti, Craig J.

    2014-03-01

    We have made precise observations of a thorium-argon hollow cathode lamp emission spectrum in the region between 350 nm and 1175 nm using a high-resolution Fourier transform spectrometer. Our measurements are combined with results from seven previously published thorium line lists to re-optimize the energy levels of neutral, singly, and doubly ionized thorium (Th I, Th II, and Th III). Using the optimized level values, we calculate accurate Ritz wavelengths for 19, 874 thorium lines between 250 nm and 5500 nm (40, 000 cm{sup –1} to 1800 cm{sup –1}). We have also found 102 new thorium energy levels. A systematic analysis of previous measurements in light of our new results allows us to identify and propose corrections for systematic errors in Palmer and Engleman and typographical errors and incorrect classifications in Kerber et al. We also found a large scatter with respect to the thorium line list of Lovis and Pepe. We anticipate that our Ritz wavelengths will lead to improved measurement accuracy for current and future spectrographs that make use of thorium-argon or thorium-neon lamps as calibration standards.

  12. Texture enhancement during grain growth of magnesium alloy AZ31B

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Bhattacharyya, Jishnu J.; Agnew, S. R.; Muralidharan, G.

    2015-01-03

    In this paper, the microstructure and texture evolution during annealing of rolled Mg alloy AZ31B, at temperatures ranging from 260 to 450°C, is characterized, and a grain growth exponent of n=5, indicating inhibition of grain growth, is observed. Broadening of the normalized grain size distributions, which indicates abnormal grain growth, was observed at all temperatures investigated. It is shown, using a Zener-type analysis for pinning of grain boundaries by particles, that impurity-based particles are responsible for grain growth inhibition and abnormal grain growth. The strong basal texture which develops during rolling of the Mg alloy, resulting in an initial peakmore » intensity in the (0002) pole figure of nine multiples of a random distribution (MRD), increases to ~15 MRD during annealing at 400 and 450°C. Furthermore, a specific texture component {0001}(1120) is observed in the orientation distribution, which increases from 10 to 23 MRD at 400°C. It is hypothesized that the anisotropic grain boundary properties (i.e. low angle boundaries have low energy and mobility) are responsible for the texture strengthening. Additionally, electron backscattered diffraction reveals the recrystallized microstructure to contain a significant number of boundaries with ~30° misorientation about the <0001> direction, and this boundary type persists throughout most annealing treatments explored.« less

  13. DOE - Office of Legacy Management -- Baker-Perkins Co - MI 13

    Office of Legacy Management (LM)

    Baker-Perkins Co - MI 13 FUSRAP Considered Sites Site: Baker-Perkins Co (MI 13) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Saginaw , Michigan MI.13-1 Evaluation Year: 1991 MI.13-1 MI.13-2 Site Operations: Small scale oxide mixing demonstrations and testing in May, 1956. MI.13-2 Site Disposition: Eliminated - Potential for contamination remote based on limited scope of activities at the site MI.13-3 Radioactive Materials Handled: Yes

  14. DOE - Office of Legacy Management -- Revere Copper and Brass Co - MI 04

    Office of Legacy Management (LM)

    Revere Copper and Brass Co - MI 04 FUSRAP Considered Sites Site: REVERE COPPER AND BRASS CO. ( MI.04 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Revere Copper and Brass MI.04-1 Location: 5851 West Jefferson Street , Detroit , Michigan MI.04-1 Evaluation Year: 1990 MI.04-2 Site Operations: Extrusion of tuballoy rods, myrnalloy rods and beryllium shapes in the 1940s. MI.04-3 MI.04-4 Site Disposition: Eliminated - Radiation levels below criteria

  15. DOE - Office of Legacy Management -- Trinity Test Site - NM 17

    Office of Legacy Management (LM)

    Trinity Test Site - NM 17 FUSRAP Considered Sites Site: TRINITY TEST SITE (NM.17 ) Eliminated from consideration under FUSRAP - U.S. Army controls site Designated Name: Not Designated Alternate Name: None Location: missile range - 30 miles west of Carrizozo , White Sands , New Mexico NM.17-1 Evaluation Year: 1985 NM.17-1 Site Operations: Detonation of the first atomic bomb occurred at this site. NM.17-1 Site Disposition: Eliminated NM.17-1 Radioactive Materials Handled: Yes Primary Radioactive

  16. Ion Exclusion by Sub 2-nm Carbon Nanotube Pores (Conference)...

    Office of Scientific and Technical Information (OSTI)

    Conference: Ion Exclusion by Sub 2-nm Carbon Nanotube Pores Citation Details In-Document Search Title: Ion Exclusion by Sub 2-nm Carbon Nanotube Pores Carbon nanotubes offer an ...

  17. RAPID/Roadmap/3-NM-d | Open Energy Information

    Open Energy Info (EERE)

    including an advanced annual rental installment. In addition, the developer must enter into the bid lease within 30 days. 19.2.9.12.A NMAC. 3-NM-d.13 to 3 NM-d.14 - Business...

  18. RAPID/Roadmap/3-NM-f | Open Energy Information

    Open Energy Info (EERE)

    from the NMDOT by contemplating affects the project may have on cultural andor environmental resources. 3-NM-f Public Highway Utility Accommodation Permit.pdf 3-NM-f Public...

  19. New Mexico Non-Taxable Transaction Certificate (NM NTTC) Request

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mexico Non-Taxable Transaction Certificate (NM NTTC) Request This form is for vendors of Los Alamos National Laboratory. To request a NM Non-Taxable Transaction Certificate (NTTC),...

  20. Electron-induced single event upsets in 28 nm and 45 nm bulk SRAMs

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Trippe, J. M.; Reed, R. A.; Austin, R. A.; Sierawski, B. D.; Weller, R. A.; Funkhouser, E. D.; King, M. P.; Narasimham, B.; Bartz, B.; Baumann, R.; et al

    2015-12-01

    In this study, we present experimental evidence of single electron-induced upsets in commercial 28 nm and 45 nm CMOS SRAMs from a monoenergetic electron beam. Upsets were observed in both technology nodes when the SRAM was operated in a low power state. The experimental cross section depends strongly on both bias and technology node feature size, consistent with previous work in which SRAMs were irradiated with low energy muons and protons. Accompanying simulations demonstrate that δ-rays produced by the primary electrons are responsible for the observed upsets. Additional simulations predict the on-orbit event rates for various Earth and Jovian environmentsmore » for a set of sensitive volumes representative of current technology nodes. The electron contribution to the total upset rate for Earth environments is significant for critical charges as high as 0.2 fC. This value is comparable to that of sub-22 nm bulk SRAMs. Similarly, for the Jovian environment, the electron-induced upset rate is larger than the proton-induced upset rate for critical charges as high as 0.3 fC.« less

  1. Electron-induced single event upsets in 28 nm and 45 nm bulk SRAMs

    SciTech Connect (OSTI)

    Trippe, J. M.; Reed, R. A.; Austin, R. A.; Sierawski, B. D.; Weller, R. A.; Funkhouser, E. D.; King, M. P.; Narasimham, B.; Bartz, B.; Baumann, R.; Schrimpf, R. D.; Labello, R.; Nichols, J.; Weeden-Wright, S. L.

    2015-12-01

    In this study, we present experimental evidence of single electron-induced upsets in commercial 28 nm and 45 nm CMOS SRAMs from a monoenergetic electron beam. Upsets were observed in both technology nodes when the SRAM was operated in a low power state. The experimental cross section depends strongly on both bias and technology node feature size, consistent with previous work in which SRAMs were irradiated with low energy muons and protons. Accompanying simulations demonstrate that δ-rays produced by the primary electrons are responsible for the observed upsets. Additional simulations predict the on-orbit event rates for various Earth and Jovian environments for a set of sensitive volumes representative of current technology nodes. The electron contribution to the total upset rate for Earth environments is significant for critical charges as high as 0.2 fC. This value is comparable to that of sub-22 nm bulk SRAMs. Similarly, for the Jovian environment, the electron-induced upset rate is larger than the proton-induced upset rate for critical charges as high as 0.3 fC.

  2. miR-17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression

    SciTech Connect (OSTI)

    Gao, Yong; Luo, Ling-hui; Li, Shuai; Yang, Cao

    2014-02-07

    Highlights: • miR-17 was increased in OS tissues and cell lines. • Inhibition of miR-17 suppressed OS cell proliferation. • Inhibition of miR-17 suppressed OS cell migration and invasion. • PTEN was a target of miR-17. • miR-17 was negatively correlated with PTEN in OS tissues. - Abstract: MicroRNAs (miRNAs) play essential roles in cancer development and progression. Here, we investigated the role of miR-17 in the progression and metastasis of osteosarcoma (OS). miR-17 was frequently increased in OS tissues and cell lines. Inhibition of miR-17 in OS cell lines substantially suppressed cell proliferation, migration, and invasion. Phosphatase and tensin homolog (PTEN) was identified as a target of miR-17, and ectopic expression of miR-17 inhibited PTEN by direct binding to its 3′-untranslated region (3′-UTR). Expression of miR-17 was negatively correlated with PTEN in OS tissues. Together, these findings indicate that miR-17 acts as an oncogenic miRNA and may contribute to the progression and metastasis of OS, suggesting miR-17 as a potential novel diagnostic and therapeutic target of OS.

  3. Paving the Way to Nanoelectronics 16 nm and Smaller

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Paving the Way to Nanoelectronics 16 nm and Smaller Paving the Way to Nanoelectronics 16 nm and Smaller Print Wednesday, 30 March 2011 00:00 As the nanoelectronics industry pushes towards feature sizes of 22 nm and smaller, conventional single-exposure refractive lithography systems used to print circuit patterns onto computer chips will no longer be feasible. Extreme ultraviolet (EUV) lithography, utilizing reflective optics and 13-nm-wavelength light to print chips, is the leading candidate to

  4. MiR-218 Mediates tumorigenesis and metastasis: Perspectives and implications

    SciTech Connect (OSTI)

    Lu, Ying-fei; Zhang, Li; Waye, Mary Miu Yee; Fu, Wei-ming; Zhang, Jin-fang

    2015-05-15

    MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers. - Highlights: • miR-218 is frequently down regulated in multiple cancers. • miR-218 plays pivotal roles in carcinogenesis. • miR-218 mediates proliferation, apoptosis, metastasis, invasion, etc. • miR-218 mediates tumorigenesis and metastasis via multiple pathways.

  5. Advanced characterization study of commercial conversion and electrocoating structures on magnesium alloys AZ31B and ZE10A

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Brady, Michael P.; Leonard, Donovan N.; Meyer, III, Harry M.; Song, Guang -Ling; Kitchen, Kris; Davis, Bruce; Thompson, J. K.; Unocic, K. A.; Elsentriecy, H. H.

    2016-03-31

    The local metal-coating interface microstructure and chemistry formed on commercial magnesium alloys Mg–3Al–1Zn (AZ31B) and Mg–1Zn–0.25Zr–<0.5Nd (ZE10A, ZEK100 type) were analyzed as-chemical conversion coated with a commercial hexafluoro-titanate/zirconate type + organic polymer based treatment (Bonderite® 5200) and a commercial hexafluoro-zirconate type + trivalent chromium Cr3 + type treatment (Surtec® 650), and after the same conversion coatings followed by electrocoating with an epoxy based coating, Cathoguard® 525. Characterization techniques included scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and cross-section scanning transmission electron microscopy (STEM). Corrosion behavior was assessed in room temperature saturated aqueous Mg(OH)2 solution with 1 wt.% NaCl. Themore » goal of the effort was to assess the degree to which substrate alloy additions become enriched in the conversion coating, and how the conversion coating was impacted by subsequent electrocoating. Key findings included the enrichment of Al from AZ31B and Zr from ZE10A, respectively, into the conversion coating, with moderate corrosion resistance benefits for AZ31B when Al was incorporated. Varying degrees of increased porosity and modification of the initial conversion coating chemistry at the metal-coating interface were observed after electrocoating. These changes were postulated to result in degraded electrocoating protectiveness. As a result, these observations highlight the challenges of coating Mg, and the need to tailor electrocoating in light of potential degradation of the initial as-conversion coated Mg alloy surface.« less

  6. HIA 2015 DOE Zero Energy Ready Home Case Study: Mandalay Homes, Vision Hill Lot 1, Glendale, AZ

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Homes Vision Hill Lot 1 Glendale, AZ DOE ZERO ENERGY READY HOME(tm) The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR Certified Homes Version 3.0 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies are designed in to

  7. Estimate of the Distribution of Solids Within Mixed Hanford Double-Shell Tank AZ-101: Implications for AY-102

    SciTech Connect (OSTI)

    Wells, Beric E.; Ressler, Jennifer J.

    2009-04-29

    This paper describes the current level of understanding of the suspension of solids in Hanford double-shell waste tanks while being mixed with the baseline configuration of two 300-horsepower mixer pumps. A mixer pump test conducted in Tank AZ-101 during fiscal year 2000 provided the basis for this understanding. Information gaps must be filled to demonstrate the capability of the baseline feed delivery system to effectively mix, sample, and deliver double-shell tank waste to the Hanford Tank Waste Treatment and Immobilization Plant (WTP) for vitrification.

  8. DOE - Office of Legacy Management -- Dow-Detroit Edison Project - MI 0-02

    Office of Legacy Management (LM)

    Dow-Detroit Edison Project - MI 0-02 FUSRAP Considered Sites Site: Dow-Detroit Edison Project (MI.0-02 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Detroit , Michigan MI.0-02-1 Evaluation Year: 1987 MI.0-02-1 Site Operations: Performed reference design work for a special fast breeder type reactor. MI.0-02-1 Site Disposition: Eliminated - No radioactive material handled at the site MI.0-02-1 Radioactive Materials Handled: No

  9. DOE - Office of Legacy Management -- Mitts-Merrill Co - MI 14

    Office of Legacy Management (LM)

    Mitts-Merrill Co - MI 14 FUSRAP Considered Sites Site: MITTS and MERRILL CO. (MI.14 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Genessee Packing Co. MI.14-1 Location: Saginaw, Michigan MI.14-1 Evaluation Year: 1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces on a small test scale during the mid-1950s. MI.14-1 Site Disposition: Eliminated - Potential for contamination considered remote based on limited quantity

  10. Superconducting and magnetic properties of <mi>Sr>3<mi>Ir>4<mi>Sn>13

    SciTech Connect (OSTI)

    Biswas, P. K.; Amato, A.; Khasanov, R.; Luetkens, H.; Wang, Kefeng; Petrovic, C.; Cook, R. M.; Lees, M. R.; Morenzoni, E.

    2014-10-10

    In this research, magnetization and muon spin relaxation or rotation (SR) measurements have been performed to study the superconducting and magnetic properties of Sr?Ir?Sn??. From magnetization measurements the lower and upper critical fields of Sr?Ir?Sn?? are found to be 81(1) Oe and 14.4(2) kOe, respectively. Zero-field SR data show no sign of any magnetic ordering or weak magnetism in Sr?Ir?Sn??. Transverse-field SR measurements in the vortex state provided the temperature dependence of the magnetic penetration depth ?. The dependence of ?? with temperature is consistent with the existence of single s-wave energy gap in the superconducting state of Sr?Ir?Sn?? with a gap value of 0.82(2) meV at absolute zero temperature. The magnetic penetration depth at zero temperature ?(0) is 291(3) nm. The ratio ?(0)/kBTc = 2.1(1) indicates that Sr?Ir?Sn?? should be considered as a strong-coupling superconductor.

  11. miRNA-205 affects infiltration and metastasis of breast cancer

    SciTech Connect (OSTI)

    Wang, Zhouquan; Department of Tumor, SenGong Hospital of Shaanxi, Xian 710300 ; Liao, Hehe; Deng, Zhiping; Yang, Po; Du, Ning; Zhanng, Yunfeng; Ren, Hong

    2013-11-08

    Highlights: We detected expression of miR-205 in breast cancer cell lines and tissue samples. We suggest miR-205 is downregulated in human breast cancer tissues and MCF7 cells. We suggest the lower expression of miR-205 play a role in breast cancer onset. These data suggest that miR-205 directly targets HER3 in human breast cancer. -- Abstract: Background: An increasing number of studies have shown that miRNAs are commonly deregulated in human malignancies, but little is known about the function of miRNA-205 (miR-205) in human breast cancer. The present study investigated the influence of miR-205 on breast cancer malignancy. Methods: The expression level of miR-205 in the MCF7 breast cancer cell line was determined by quantitative (q)RT-PCR. We then analyzed the expression of miR-205 in breast cancer and paired non-tumor tissues. Finally, the roles of miR-205 in regulating tumor proliferation, apoptosis, migration, and target gene expression were studied by MTT assay, flow cytometry, qRT-PCR, Western blotting and luciferase assay. Results: miR-205 was downregulated in breast cancer cells or tissues compared with normal breast cell lines or non-tumor tissues. Overexpression of miR-205 reduced the growth and colony-formation capacity of MCF7 cells by inducing apoptosis. Overexpression of miR-205 inhibited MCF7 cell migration and invasiveness. By bioinformation analysis, miR-205 was predicted to bind to the 3? untranslated regions of human epidermal growth factor receptor (HER)3 mRNA, and upregulation of miR-205 reduced HER3 protein expression. Conclusion: miR-205 is a tumor suppressor in human breast cancer by post-transcriptional inhibition of HER3 expression.

  12. Paving the Way to Nanoelectronics 16 nm and Smaller

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Paving the Way to Nanoelectronics 16 nm and Smaller Print As the nanoelectronics industry pushes towards feature sizes of 22 nm and smaller, conventional single-exposure refractive lithography systems used to print circuit patterns onto computer chips will no longer be feasible. Extreme ultraviolet (EUV) lithography, utilizing reflective optics and 13-nm-wavelength light to print chips, is the leading candidate to meet the industry's future needs. Despite strong progress in EUV lithography over

  13. Paving the Way to Nanoelectronics 16 nm and Smaller

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Paving the Way to Nanoelectronics 16 nm and Smaller Print As the nanoelectronics industry pushes towards feature sizes of 22 nm and smaller, conventional single-exposure refractive lithography systems used to print circuit patterns onto computer chips will no longer be feasible. Extreme ultraviolet (EUV) lithography, utilizing reflective optics and 13-nm-wavelength light to print chips, is the leading candidate to meet the industry's future needs. Despite strong progress in EUV lithography over

  14. Paving the Way to Nanoelectronics 16 nm and Smaller

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Paving the Way to Nanoelectronics 16 nm and Smaller Print As the nanoelectronics industry pushes towards feature sizes of 22 nm and smaller, conventional single-exposure refractive lithography systems used to print circuit patterns onto computer chips will no longer be feasible. Extreme ultraviolet (EUV) lithography, utilizing reflective optics and 13-nm-wavelength light to print chips, is the leading candidate to meet the industry's future needs. Despite strong progress in EUV lithography over

  15. Paving the Way to Nanoelectronics 16 nm and Smaller

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Paving the Way to Nanoelectronics 16 nm and Smaller Print As the nanoelectronics industry pushes towards feature sizes of 22 nm and smaller, conventional single-exposure refractive lithography systems used to print circuit patterns onto computer chips will no longer be feasible. Extreme ultraviolet (EUV) lithography, utilizing reflective optics and 13-nm-wavelength light to print chips, is the leading candidate to meet the industry's future needs. Despite strong progress in EUV lithography over

  16. Paving the Way to Nanoelectronics 16 nm and Smaller

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Paving the Way to Nanoelectronics 16 nm and Smaller Print As the nanoelectronics industry pushes towards feature sizes of 22 nm and smaller, conventional single-exposure refractive lithography systems used to print circuit patterns onto computer chips will no longer be feasible. Extreme ultraviolet (EUV) lithography, utilizing reflective optics and 13-nm-wavelength light to print chips, is the leading candidate to meet the industry's future needs. Despite strong progress in EUV lithography over

  17. Paving the Way to Nanoelectronics 16 nm and Smaller

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Paving the Way to Nanoelectronics 16 nm and Smaller Print As the nanoelectronics industry pushes towards feature sizes of 22 nm and smaller, conventional single-exposure refractive lithography systems used to print circuit patterns onto computer chips will no longer be feasible. Extreme ultraviolet (EUV) lithography, utilizing reflective optics and 13-nm-wavelength light to print chips, is the leading candidate to meet the industry's future needs. Despite strong progress in EUV lithography over

  18. NuMI Low Energy Flux Prediction Release

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NuMI Low Energy Flux Prediction Release Neutrino Flux Predictions for the NuMI Beam hep-ex/1607.00704 Data Ancillary data files for this result are available on arXiv at http://arxiv.org/src/1607.00704/anc.< /li> Among the available data files are: pdf file describing format of all the available files root file of all the available fluxes python code to read and process MINERvA's flux predictions Text Files of the flux, uncertainties, and covariance matrix, with units of neutrinos/m^2/POT,

  19. Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    (Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 1 2014 1 1 1 1 2 1 1 1 1 1 2015 1 1 1 1 1 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 08/31/2016 Next Release Date: 09/30/2016 Referring Pages: U.S. Liquefied Natural Gas Exports by Point of Exit Port Huron, MI LNG Exports to All Countries

  20. NM (United States)] 72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS...

    Office of Scientific and Technical Information (OSTI)

    Clayton, Steven Los Alamos National Lab. (LANL), Los Alamos, NM (United States) 72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS; 73 NUCLEAR PHYSICS AND RADIATION PHYSICS;...

  1. RAPID/Roadmap/12-NM-a | Open Energy Information

    Open Energy Info (EERE)

    Biological Resource Considerations (12-NM-a) The New Mexico Department of Game and Fish (NMDGF) preserves endangered or threatened wildlife in the state against any direct...

  2. RAPID/Roadmap/11-NM-b | Open Energy Information

    Open Energy Info (EERE)

    Permitting Information Desktop Toolkit BETA About Bulk Transmission Geothermal Hydropower Solar Tools Contribute Contact Us Cultural Resource Investigation Process (11-NM-b) Before...

  3. RAPID/Roadmap/3-NM-c | Open Energy Information

    Open Energy Info (EERE)

    Permitting Information Desktop Toolkit BETA About Bulk Transmission Geothermal Hydropower Solar Tools Contribute Contact Us State Encroachment Process (3-NM-c) The New Mexico...

  4. Structure of a novel 13 nm dodecahedral nanocage assembled from...

    Office of Scientific and Technical Information (OSTI)

    Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein Citation Details In-Document Search Title: Structure of a ...

  5. RAPID/Roadmap/15-NM-a | Open Energy Information

    Open Energy Info (EERE)

    BETA About Bulk Transmission Geothermal Hydropower Solar Tools Contribute Contact Us Air Quality Permit - Construction Permit (15-NM-a) This flowchart illustrates the process...

  6. RAPID/Roadmap/15-NM-c | Open Energy Information

    Open Energy Info (EERE)

    BETA About Bulk Transmission Geothermal Hydropower Solar Tools Contribute Contact Us Air Quality Permit - Operating Permit (15-NM-c) This flowchart illustrates the process for...

  7. RAPID/Roadmap/15-NM-b | Open Energy Information

    Open Energy Info (EERE)

    BETA About Bulk Transmission Geothermal Hydropower Solar Tools Contribute Contact Us Air Quality Permit - Accelerated Construction Permit Review (15-NM-b) The developer may...

  8. Paving the Way to Nanoelectronics 16 nm and Smaller

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    will no longer be feasible. Extreme ultraviolet (EUV) lithography, utilizing reflective optics and 13-nm-wavelength light to print chips, is the leading candidate to meet the...

  9. RAPID/Roadmap/5-NM-a | Open Energy Information

    Open Energy Info (EERE)

    Hydropower Solar Tools Contribute Contact Us Drilling and Well Development (5-NM-a) The Oil Conservation Division of the New Mexico Energy, Minerals and Natural Resources...

  10. RAPID/Roadmap/7-NM-c | Open Energy Information

    Open Energy Info (EERE)

    NM-c < RAPID | Roadmap Jump to: navigation, search RAPID Regulatory and Permitting Information Desktop Toolkit BETA About Bulk Transmission Geothermal Hydropower Solar Tools...

  11. RAPID/Roadmap/14-NM-b | Open Energy Information

    Open Energy Info (EERE)

    Roadmap14-NM-b < RAPID | Roadmap Jump to: navigation, search RAPID Regulatory and Permitting Information Desktop Toolkit BETA About Bulk Transmission Geothermal Hydropower...

  12. RAPID/Roadmap/3-NM-b | Open Energy Information

    Open Energy Info (EERE)

    RAPIDRoadmap3-NM-b < RAPID | Roadmap Jump to: navigation, search RAPID Regulatory and Permitting Information Desktop Toolkit BETA About Bulk Transmission Geothermal Hydropower...

  13. Paving the Way to Nanoelectronics 16 nm and Smaller

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... beyond 22-nm half pitch," Proc. SPIE 7636, 76361J (2010); P. Naulleau, C. ... resist and mask materials learning," Proc. SPIE 7985, 798509 (2011). ALS Science Highlight ...

  14. RAPID/Roadmap/14-NM-c | Open Energy Information

    Open Energy Info (EERE)

    Geothermal Hydropower Solar Tools Contribute Contact Us Underground Injection Control Permit (14-NM-c) The Underground Injection Control (UIC) Permit process in New Mexico...

  15. RAPID/Roadmap/19-NM-a | Open Energy Information

    Open Energy Info (EERE)

    BETA About Bulk Transmission Geothermal Hydropower Solar Tools Contribute Contact Us Water Access and Water Rights Overview (19-NM-a) Similar to many western states, only a...

  16. Sandia, the Atlantic Council, and NM Water Resource Research...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the Atlantic Council, and NM Water Resource Research Institute Sponsor Roundtable on Western Water Scarcity - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us ...

  17. DOE - Office of Legacy Management -- LASL Tract OO - NM 06

    Office of Legacy Management (LM)

    Tract OO - NM 06 FUSRAP Considered Sites Site: LASL TRACT OO (NM.06 ) Eliminated from consideration under FUSRAP - Site was released by the AEC for sale and unrestricted use in 1976 Designated Name: Not Designated Alternate Name: None Location: Los Alamos , New Mexico NM.06-1 Evaluation Year: 1987 NM.06-1 Site Operations: Site consists of an area of 3.85 acres on the Los Alamos Scientific Laboratory compound. This tract of land was a location for a fire alarm equipment building and part of power

  18. RAPID/Roadmap/3-NM-a | Open Energy Information

    Open Energy Info (EERE)

    State Land Office (NMSLO) to develop geothermal resources on state lands under the New Mexico Geothermal Resources Act and regulations promulgated in N.M. Admin. Code part...

  19. RAPID/Roadmap/11-NM-a | Open Energy Information

    Open Energy Info (EERE)

    where cultural resources are discovered during the project. In instances where human burials are discovered, the requirements are more stringent. 11-NM-a State Cultural...

  20. DOE - Office of Legacy Management -- ACF Industries - NM 05

    Office of Legacy Management (LM)

    Eliminated from consideration under FUSRAP - DOD site Designated Name: Not Designated ... from consideration under FUSRAP - DOD site NM.05-3 Also see Documents Related to ...

  1. Generation and use of high power 213 nm and 266 nm laser radiation and tunable 210-400 nm laser radiation with BBO crystal matrix array

    DOE Patents [OSTI]

    Gruen, Dieter M.

    2000-01-01

    A 213 nm laser beam is capable of single photon ablative photodecomposition for the removal of a polymer or biological material substrate. Breaking the molecular bonds and displacing the molecules away from the substrate in a very short time period results in most of the laser photon energy being carried away by the displaced molecules, thus minimizing thermal damage to the substrate. The incident laser beam may be unfocussed and is preferably produced by quintupling the 1064 nm radiation from a Nd:YAG solid state laser, i.e., at 213 nm. In one application, the 213 nm laser beam is expanded in cross section and directed through a plurality of small beta barium borate (BBO) crystals for increasing the energy per photon of the laser radiation directed onto the substrate. The BBO crystals are arranged in a crystal matrix array to provide a large laser beam transmission area capable of accommodating high energy laser radiation without damaging the BBO crystals. The BBO crystal matrix array may also be used with 266 nm laser radiation for carrying out single or multi photon ablative photodecomposition. The BBO crystal matrix array may also be used in an optical parametric oscillator mode to generate high power tunable laser radiation in the range of 210-400 nm.

  2. Ground Motion Studies at NuMI

    SciTech Connect (OSTI)

    Mayda M. Velasco; Michal Szleper

    2012-02-20

    Ground motion can cause significant deterioration in the luminosity of a linear collider. Vibration of numerous focusing magnets causes continuous misalignments, which makes the beam emittance grow. For this reason, understanding the seismic vibration of all potential LC sites is essential and related efforts in many sites are ongoing. In this document we summarize the results from the studies specific to Fermilab grounds as requested by the LC project leader at FNAL, Shekhar Mishra in FY04-FY06. The Northwestern group focused on how the ground motion effects vary with depth. Knowledge of depth dependence of the seismic activity is needed in order to decide how deep the LC tunnel should be at sites like Fermilab. The measurements were made in the NuMI tunnel, see Figure 1. We take advantage of the fact that from the beginning to the end of the tunnel there is a height difference of about 350 ft and that there are about five different types of dolomite layers. The support received allowed to pay for three months of salary of Michal Szleper. During this period he worked a 100% of his time in this project. That include one week of preparation: 2.5 months of data taking and data analysis during the full period of the project in order to guarantee that we were recording high quality data. We extended our previous work and made more systematic measurements, which included detailed studies on stability of the vibration amplitudes at different depths over long periods of time. As a consequence, a better control and more efficient averaging out of the daytime variation effects were possible, and a better study of other time dependences before the actual depth dependence was obtained. Those initial measurements were made at the surface and are summarized in Figure 2. All measurements are made with equipment that we already had (two broadband seismometers KS200 from GEOTECH and DL-24 portable data recorder). The offline data analysis took advantage of the full Fourier spectra

  3. DOE - Office of Legacy Management -- Mitts-Merrel Co - MI 14

    Office of Legacy Management (LM)

    1993 MI.14-2 Site Operations: Reduced thorium metal chunks into particle sized pieces ... Primary Radioactive Materials Handled: Thorium MI.14-1 Radiological Survey(s): Yes - ...

  4. DOE - Office of Legacy Management -- Amex Specialty Metal Corp - MI 0-01

    Office of Legacy Management (LM)

    Amex Specialty Metal Corp - MI 0-01 FUSRAP Considered Sites Site: Amex Specialty Metal Corp (MI.0-01 ) Eliminated from further consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Coldwater , Michigan MI.0-01-1 Evaluation Year: 1987 MI.0-01-1 Site Operations: No indication that AMEX performed work for MED or AEC activities. Originally included on FUSRAP list due to fact that AMEX purchased milling equipment from a company that had done uranium milling.

  5. MiR-125a TNF receptor-associated factor 6 to inhibit osteoclastogenesis

    SciTech Connect (OSTI)

    Guo, Li-Juan; Liao, Lan; Yang, Li; Li, Yu; Jiang, Tie-Jian

    2014-02-15

    MicroRNAs (miRNAs) play important roles in osteoclastogenesis and bone resorption. In the present study, we found that miR-125a was dramatically down-regulated during macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) induced osteoclastogenesis of circulating CD14+ peripheral blood mononuclear cells (PBMCs). Overexpression of miR-125a in CD14+ PBMCs inhibited osteoclastogenesis, while inhibition of miR-125a promoted osteoclastogenesis. TNF receptor-associated factor 6 (TRAF6), a transduction factor for RANKL/RANK/NFATc1 signal, was confirmed to be a target of miR-125a. EMSA and ChIP assays confirmed that NFATc1 bound to the promoter of the miR-125a. Overexpression of NFATc1 inhibited miR-125a transcription, and block of NFATc1 expression attenuated RANKL-regulated miR-125a transcription. Here, we reported that miR-125a played a biological function in osteoclastogenesis through a novel TRAF6/ NFATc1/miR-125a regulatory feedback loop. It suggests that regulation of miR-125a expression may be a potential strategy for ameliorating metabolic disease. - Highlights: • MiR-125a was significantly down-regulated in osteoclastogenesis of CD14+ PBMCs. • MiR-125a inhibited osteoclast differentiation by targeting TRAF6. • NFATc1 inhibited miR-125a transciption by binding to the promoter of miR-125a. • TRAF6/NFATc1 and miR-125a form a regulatory feedback loop in osteoclastogenesis.

  6. MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma

    SciTech Connect (OSTI)

    Xiong, Xinkui; Sun, Daoyi; Chai, Hao; Shan, Wengang; Yu, Yue; Pu, Liyong; Cheng, Feng

    2015-09-18

    The dysregulation of micro (mi)RNAs is associated with cancer development. The miRNA miR-145 is downregulated in intrahepatic cholangiocarcinoma (ICC); however, its precise role in tumor progression has not yet been elucidated. Novel (nua) kinase family (NUAK)1 functions as an oncogene in various cancers and is a putative target of miR-145 regulation. In this study, we investigated the regulation of NUAK1 by miR-145 in ICC. We found that miR-145 level was significantly decreased in ICC tissue and cell lines, which corresponded with an increase in NUAK1 expression. NUAK1 was found to be a direct target of miR-145 regulation. The overexpression of miR-145 in ICC cell lines inhibited proliferation, growth, and invasion by suppressing NUAK1 expression, which was associated with a decrease in Akt signaling and matrix metalloproteinase protein expression. Similar results were observed by inhibiting NUAK1 expression. These results demonstrate that miR-145 can prevent ICC progression by targeting NUAK1 and its downstream effectors, and can therefore be useful for clinical diagnosis and targeted therapy of ICC. - Highlights: • MiR-145 suppresses ICC proliferation and invasion abilities. • We demonstrated that miR-145 directly targets NUAK1 in ICC. • MiR-145 expression in ICC was associated with Akt signaling and MMPs expression.

  7. Neutron scattering study of spin ordering and stripe pinning in superconducting <mi>La>1.93<mi>Sr>0.07<mi>CuO>4

    SciTech Connect (OSTI)

    Jacobsen, H.; Zaliznyak, I. A.; Savici, A. T.; Winn, B. L.; Chang, S.; Hücker, M.; Gu, G. D.; Tranquada, J. M.

    2015-11-20

    The relationships among charge order, spin fluctuations, and superconductivity in underdoped cuprates remain controversial. We use neutron scattering techniques to study these phenomena in <mi>La>1.93<mi>Sr>0.07<mi>CuO>4 a superconductor with a transition temperature of Tc = 20 K. At T<< Tc, we find incommensurate spin fluctuations with a quasielastic energy spectrum and no sign of a gap within the energy range from 0.2 to 15 meV. A weak elastic magnetic component grows below ~ 10 K, consistent with results from local probes. Regarding the atomic lattice, we have discovered unexpectedly strong fluctuations of the CuO6 octahedra about Cu-O bonds, which are associated with inequivalent O sites within the CuO2 planes. Moreover, we observed a weak elastic (3 30) superlattice peak that implies a reduced lattice symmetry. The presence of inequivalent O sites rationalizes various pieces of evidence for charge stripe order in underdoped La2-xSrxCuO4. The coexistence of superconductivity with quasi-static spin-stripe order suggests the presence of intertwined orders; however, the rotation of the stripe orientation away from the Cu-O bonds might be connected with evidence for a finite gap at the nodal points of the superconducting gap function.

  8. Radiosensitizing Effects of Ectopic miR-101 on Non-Small-Cell Lung Cancer Cells Depend on the Endogenous miR-101 Level

    SciTech Connect (OSTI)

    Chen, Susie; Wang Hongyan; Ng, Wooi Loon; Curran, Walter J.; Wang Ya

    2011-12-01

    Purpose: Previously, we showed that ectopic miR-101 could sensitize human tumor cells to radiation by targeting ATM and DNA-PK catalytic subunit (DNA-PKcs) to inhibit DNA repair, as the endogenous miR-101 levels are low in tumors in general. However, the heterogeneity of human cancers may result in an exception. The purpose of this study was to test the hypothesis that a few tumor cell lines with a high level of endogenous miR-101 would prove less response to ectopic miR-101. Methods and Materials: Fourteeen non-small-cell lung cancer (NSCLC) cell lines and one immortalized non-malignant lung epithelial cell line (NL20) were used for comparing endogenous miR-101 levels by real-time reverse transcription-polymerase chain reaction. Based on the different miR-101 levels, four cell lines with different miR-101 levels were chosen for transfection with a green fluorescent protein-lentiviral plasmid encoding miR-101. The target protein levels were measured by using Western blotting. The radiosensitizing effects of ectopic miR-101 on these NSCLC cell lines were determined by a clonogenic assay and xenograft mouse model. Results: The endogenous miR-101 level was similar or lower in 13 NSCLC cell lines but was 11-fold higher in one cell line (H157) than in NL20 cells. Although ectopic miR-101 efficiently decreased the ATM and DNA-PKcs levels and increased the radiosensitization level in H1299, H1975, and A549 cells, it did not change the levels of the miR-101 targets or radiosensitivity in H157 cells. Similar results were observed in xenograft mice. Conclusions: A small number of NSCLC cell lines could have a high level of endogenous miR-101. The ectopic miR-101 was able to radiosensitize most NSCLC cells, except for the NSCLC cell lines that had a much higher endogenous miR-101 level. These results suggest that when we choose one miRNA as a therapeutic tool, the endogenous level of the miRNA in each tumor should be considered.

  9. F-1 U.S. Energy Information Administration | Annual Energy Outlook...

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    Central West North Central East North Central Mountain AK WA MT WY ID NV UT CO AZ NM TX OK IA KS MO IL IN KY TN MS AL FL GA SC NC WV PA NJ MD DE NY CT VT ME RI MA NH VA WI MI OH...

  10. F-5 U.S. Energy Information Administration | Annual Energy Outlook...

    Annual Energy Outlook [U.S. Energy Information Administration (EIA)]

    Figure F4. Oil and Gas Supply Model Regions Atlantic WA MT WY ID NV UT CO AZ NM TX OK IA KS MO IL IN KY TN MS AL FL GA SC NC WV PA NJ MD DE NY CT ME RI MA NH VA WI MI OH NE...

  11. New Mexico Non-Taxable Transaction Certificate (NM NTTC) Request

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mexico Non-Taxable Transaction Certificate (NM NTTC) Request This form is for vendors of Los Alamos National Laboratory. To request a NM Non-Taxable Transaction Certificate (NTTC), please provide the information requested below. Request can be submitted by mail, email or fax to: Los Alamos National Laboratory P.O. Box 1663 Accounts Payable, MS P240 Los Alamos, NM 87545 Fax: (505) 665-8357 processsupport@lanl.gov Company Name (as registered with Tax Authority) NOTE: If registered with the State

  12. Abnormal macropore formation during double-sided gas tungsten arc welding of magnesium AZ91D alloy

    SciTech Connect (OSTI)

    Shen Jun You Guoqiang; Long Siyuan; Pan Fusheng

    2008-08-15

    One of the major concerns during gas tungsten arc (GTA) welding of cast magnesium alloys is the presence of large macroporosity in weldments, normally thought to occur from the presence of gas in the castings. In this study, a double-sided GTA welding process was adopted to join wrought magnesium AZ91D alloy plates. Micropores were formed in the weld zone of the first side that was welded, due to precipitation of H{sub 2} as the mushy zone freezes. When the reverse side was welded, the heat generated caused the mushy zone in the initial weld to reform. The micropores in the initial weld then coalesced and expanded to form macropores by means of gas expansion through small holes that are present at the grain boundaries in the partially melted zone. Macropores in the partially melted zone increase with increased heat input, so that when a filler metal is used the macropores are smaller in number and in size.

  13. RAPID/Roadmap/6-NM-b | Open Energy Information

    Open Energy Info (EERE)

    storm water permit must comply with the process outlined in Green arrow.PNG 6-FD-a: Storm Water Construction General Permit Process Flowchart 6-NM-b Construction Storm...

  14. NM Underground Storage Tank Registration | Open Energy Information

    Open Energy Info (EERE)

    Underground Storage Tank Registration Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- OtherOther: NM Underground Storage Tank RegistrationLegal...

  15. Photoluminescent 1-2 nm sized silicon nanoparticles: A surface...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Photoluminescent 1-2 nm sized silicon nanoparticles: A surface-dependent system Authors: Romero, J.J., Llansola-Portols, M.J., Dell'Arciprete, M.L., Rodrguez, H.B., Moore,...

  16. RAPID/Roadmap/14-NM-e | Open Energy Information

    Open Energy Info (EERE)

    Ground Water Discharge Permit (14-NM-e) The New Mexico Environment Department (NMED) issues Ground Water Discharge Permits in the state of New Mexico. No person may cause or...

  17. RAPID/Roadmap/19-NM-b | Open Energy Information

    Open Energy Info (EERE)

    a new permit and fee will be required for any drilling beyond the permit expiration date. Process Flowchart 19-NM-b - Permit to Drill a Well with No Consumptive Use of Water.pdf...

  18. File:INL-geothermal-nm.pdf | Open Energy Information

    Open Energy Info (EERE)

    nm.pdf Jump to: navigation, search File File history File usage New Mexico Geothermal Resources Size of this preview: 466 599 pixels. Other resolution: 467 600 pixels. Full...

  19. RAPID/Roadmap/11-NM-d | Open Energy Information

    Open Energy Info (EERE)

    discovery process. NMAC 4.10.8.20. 11-NM-d Cultural Resource Discovery Process.pdf Error creating thumbnail: Page number not in range. Error creating thumbnail: Page number...

  20. RAPID/Roadmap/20-NM-a | Open Energy Information

    Open Energy Info (EERE)

    and abandonment are outlined in NMAC 19.14.73.8. 20-NM-a - Well Abandonment Process.pdf Error creating thumbnail: Page number not in range. Error creating thumbnail: Page number...

  1. Paving the Way to Nanoelectronics 16 nm and Smaller

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    at ALS Beamline 12.0.1.3, advanced EUV photoresist research can be performed while high-power stand-alone light sources are still being developed. High-quality 16-nm lines and...

  2. DOE - Office of Legacy Management -- Project Gnome Site - NM 12

    Office of Legacy Management (LM)

    Gnome Site - NM 12 FUSRAP Considered Sites Site: Project Gnome Site (NM.12) Designated Name: Alternate Name: Location: Evaluation Year: Site Operations: Site Disposition: Radioactive Materials Handled: Primary Radioactive Materials Handled: Radiological Survey(s): Site Status: Also see Gnome-Coach, New Mexico, Site Documents Related to Project Gnome Site Conditional Certificate of Completion. Attached letter from New Mexico Environment Department of DOE dated September 25, 2014. Fact Sheet

  3. Origin State>> CA CA ID ID ID IL KY MD MO NM NM NY NY OH SC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MO NM NM NY NY OH SC TN TN TN, WA, CA TN TN TN TN Total Shipments by Route Lawrence Livermore National Laboratory General Atomics Batelle Energy Alliance Idaho National Laboratory Advanced Mixed Waste Treatment Project Argonne National Laboratory Paducah Gaseous Diffusion Plant Aberdeen Proving Grounds National Security Technologies Sandia National Laboratory Los Alamos National Laboratory Brookhaven National Laboratory CH2M Hill B&W West Valley, LLC Portsmouth Gaseous Diffusion Plant

  4. Origin State>> CA CA ID ID ID IL KY MD NM NM NV NY NY OH TN

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NM NM NV NY NY OH TN TN TN, WA, CA TN TN TN TN TX Total Shipments by Route Lawrence Livermore National Laboratory General Atomics Advanced Mixed Waste Treatment Project Batelle Energy Alliance Idaho National Laboratory Argonne National Laboratory Paducah Gaseous Diffusion Plant Aberdeen Proving Ground Los Alamos National Laboratory Sandia National Laboratory National Security Technologies Brookhaven National Laboratory West Valley Environmental Services Portsmouth Gaseous Diffusion Plant

  5. Origin State>> CA ID ID ID IL KY MD NM NM NY NY OH SC TN TN

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MD NM NM NY NY OH SC TN TN TN, WA, CA TN TN TN TN TX Total Shipments by Route Lawrence Livermore National Laboratory Advanced Mixed Waste Treatment Project Batelle Energy Alliance Idaho National Laboratory Argonne National Laboratory Paducah Gaseous Diffusion Plant Aberdeen Proving Ground Los Alamos National Laboratory Sandia National Laboratory Brookhaven National Laboratory West Valley Environmental Services Portsmouth Gaseous Diffusion Plant Savannah River Site Duratek/Energy Solutions Babcox

  6. Origin State>> CA ID ID ID IL NM NM OH TN TN TN, WA, CA TN TN

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NM NM OH TN TN TN, WA, CA TN TN TN TN TX Total Shipments by Route Lawrence Livermore National Laboratory Batelle Energy Alliance Idaho National Laboratory Advanced Mixed Waste Treatment Project Argonne National Laboratory Sandia National Laboratory Los Alamos National Laboratory Portsmouth Gaseous Diffusion Plant Duratek/Energy Solutions Babcox & Wilcox Technical Services Y-12 Plant Materials & Energy Corporation (M&EC) Perma-Fix Nuclear Fuels Services Wastren Advantage, Inc.

  7. Origin State>> CA ID ID IL IL KY NM NM NV NY OH TN TN TN, WA,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    IL IL KY NM NM NV NY OH TN TN TN, WA, CA TN TN TN TN Total Shipments by Route Lawrence Livermore National Laboratory Batelle Energy Alliance Idaho National Laboratory Energx Argonne National Laboratory Argonne National Laboratory Paducah Gaseous Diffusion Plant Sandia National Laboratory Los Alamos National Laboratory National Security Technologies West Valley Environmental Services Portsmouth Gaseous Diffusion Plant Duratek/Energy Solutions Babcox & Wilcox Technical Services Y-12 Plant

  8. Survey of lands held for uranium exploration, development, and production in fourteen western states for the six-month period ending December 31, 1982. [AZ, CA, CO, ID, MT, NV, NM, ND, OR, SD, TX, UT, WA, WY

    SciTech Connect (OSTI)

    Not Available

    1983-04-01

    Tables are presented showing the land held (in thousands of acres) for uranium exploration and development according to: (1) distribution by ownership for 14 western states; (2) distribution by state; distribution by land category. A graph is presented showing land held by uranium industry from January 1966 to January 1983. Land controlled by counties for each of the 14 states are also tabulated according to land category. (ATT)

  9. Survey of lands held for uranium exploration, development, and production in fourteen western states for the six-month period ending June 30, 1982. [AZ, CA, CO, ID, MT, NV, NM, ND, OR, SD, TX, UT, WA, WY

    SciTech Connect (OSTI)

    Not Available

    1982-10-01

    Tables are presented showing the land held (in thousands of acres) for uranium exploration according to: (1) distribution by ownership for 14 western states (state, claim, federally acquired, Indian and fee); (2) distribution by state (1976 to 1982); (3) distribution by land category (1976 to 1982). A graph is presented showing land held by uranium industry from January 1966 to January 1982. Land controlled by counties for each of the 14 states are also tabulated according to land category. (ATT)

  10. NM company wants to turn your windows into solar panels

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NM company wants to turn your windows into solar panels NM company wants to turn your windows into solar panels "There's an opportunity to generate electricity and power buildings with their windows" August 1, 2016 The UbiQD Team The UbiQD team celebrates the opening of its new quantum dot manufacturing facility in Los Alamos July 29. Contact Hunter McDaniel UbiQD Email UbiQD LLC, a quantum dot company, says it can turn windows into solar generators. "There's an opportunity to

  11. La Fonda on the Plaza, Santa Fe, NM: June 1

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sequencing, Finishing, and Analysis in the Future (SFAF) La Fonda on the Plaza, Santa Fe, NM: June 1 st - 3 rd , 2016 Please join us for the 11 th annual "Sequencing, Finishing and Analysis in the Future" Meeting on Wednesday, June 1 st through June 3 rd in beautiful, historic Santa Fe, NM. The three-day SFAF conference will focus on Next Generation Sequencing technologies, applications, and their effect on the rapidly advancing field of Genomics. If you have any questions, or would

  12. Evolution of the microstructure and hardness of a rapidly solidified/melt-spun AZ91 alloy upon aging at different temperatures

    SciTech Connect (OSTI)

    Wang Baishu; Liu Yongbing; An Jian; Li Rongguang; Su Zhenguo; Su Guihua; Lu You; Cao Zhanyi

    2009-04-15

    The effect of aging at different temperatures on a rapidly solidified/melt-spun AZ91 alloy has been investigated in depth. The microstructures of as-spun and aged ribbons with a thickness of approximately 60 {mu}m were characterized using X-ray diffraction, transmission electron microscopy and laser optical microscopy; microhardness measurements were also conducted. It was found that the commercial AZ91 alloy undergoes a cellular/dendritic transition during melt-spinning at a speed of 34 m/s. A strengthening effect due to aging was observed: a maximum hardness of 110 HV/0.05 and an age-hardenability of 50% were obtained when the ribbon was aged at 200 deg. C for 20 min. The {beta}-Mg{sub 17}Al{sub 12} phase exhibits net and dispersion types of distribution during precipitation. The dispersion of precipitates in dendritic grains or cells is the main source of strengthening.

  13. FINAL REPORT DM1200 TESTS WITH AZ 101 HLW SIMULANTS VSL-03R3800-4 REV 0 2/17/04

    SciTech Connect (OSTI)

    KRUGER AA; MATLACK KS; BARDAKCI T; D'ANGELO NA; GONG W; KOT WK; PEGG IL

    2011-12-29

    This report documents melter and off-gas performance results obtained on the DM 1200 HLW Pilot Melter during processing of simulated HLW AZ-101 feed. The principal objectives of the DM1200 melter testing were to determine the achievable glass production rates for simulated HLW AZ-101 feed; determine the effect of bubbling rate and feed solids content on production rate; characterize melter off-gas emissions; characterize the performance of the prototypical off-gas system components as well as their integrated performance; characterize the feed, glass product, and off-gas effluents; and to perform pre- and post-test inspections of system components. The test objectives (including test success criteria), along with how they were met, are outlined in a table.

  14. DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1

    SciTech Connect (OSTI)

    Lerner, Mikael; Harada, Masako; Loven, Jakob; Castro, Juan; Davis, Zadie; Oscier, David; Henriksson, Marie; Sangfelt, Olle; Grander, Dan; Corcoran, Martin M.

    2009-10-15

    The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. Despite their abundance in most cells the transcriptional regulation of miR-15a/16-1 remains unclear. Here we demonstrate that the putative tumor suppressor DLEU2 acts as a host gene of these microRNAs. Mature miR-15a/miR-16-1 are produced in a Drosha-dependent process from DLEU2 and binding of the Myc oncoprotein to two alterative DLEU2 promoters represses both the host gene transcript and levels of mature miR-15a/miR-16-1. In line with a functional role for DLEU2 in the expression of the microRNAs, the miR-15a/miR-16-1 locus is retained in four CLL cases that delete both promoters of this gene and expression analysis indicates that this leads to functional loss of mature miR-15a/16-1. We additionally show that DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. Together the data illuminate how inactivation of DLEU2 promotes cell proliferation and tumor progression through functional loss of miR-15a/miR-16-1.

  15. Genome-Wide Analysis of miRNA targets in Brachypodium and Biomass Energy Crops

    SciTech Connect (OSTI)

    Green, Pamela J.

    2015-08-11

    MicroRNAs (miRNAs) contribute to the control of numerous biological processes through the regulation of specific target mRNAs. Although the identities of these targets are essential to elucidate miRNA function, the targets are much more difficult to identify than the small RNAs themselves. Before this work, we pioneered the genome-wide identification of the targets of Arabidopsis miRNAs using an approach called PARE (German et al., Nature Biotech. 2008; Nature Protocols, 2009). Under this project, we applied PARE to Brachypodium distachyon (Brachypodium), a model plant in the Poaceae family, which includes the major food grain and bioenergy crops. Through in-depth global analysis and examination of specific examples, this research greatly expanded our knowledge of miRNAs and target RNAs of Brachypodium. New regulation in response to environmental stress or tissue type was found, and many new miRNAs were discovered. More than 260 targets of new and known miRNAs with PARE sequences at the precise sites of miRNA-guided cleavage were identified and characterized. Combining PARE data with the small RNA data also identified the miRNAs responsible for initiating approximately 500 phased loci, including one of the novel miRNAs. PARE analysis also revealed that differentially expressed miRNAs in the same family guide specific target RNA cleavage in a correspondingly tissue-preferential manner. The project included generation of small RNA and PARE resources for bioenergy crops, to facilitate ongoing discovery of conserved miRNA-target RNA regulation. By associating specific miRNA-target RNA pairs with known physiological functions, the research provides insights about gene regulation in different tissues and in response to environmental stress. This, and release of new PARE and small RNA data sets should contribute basic knowledge to enhance breeding and may suggest new strategies for improvement of biomass energy crops.

  16. DOE - Office of Legacy Management -- TA-1 Manhattan Laboratory - NM 11

    Office of Legacy Management (LM)

    TA-1 Manhattan Laboratory - NM 11 FUSRAP Considered Sites Site: TA-1 MANHATTAN LABORATORY (NM.11 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: Main Technical Area LASL LANL NM.11-1 NM.11-2 NM.11-3 Location: Los Alamos , New Mexico NM.11-3 Evaluation Year: 1985 NM.11-1 Site Operations: Nuclear weapons research and development. NM.11-1 NM.11-3 Site Disposition: Site Disposition NM.11-1 Radioactive Materials Handled: Yes Primary Radioactive Materials

  17. EUV optical design for 100 nm CD imaging system

    SciTech Connect (OSTI)

    Sweeney, D.W.; Hudyma, R.; Chapman, H.B.; Shafer, D.

    1998-04-09

    The imaging specifications for extreme ultraviolet lithography (EUVL) projection optics parallel those of other optical lithographies. Specifications are scaled to reflect the 100 nm critical dimension for the first generation EUVL systems. The design being fabricated for the Engineering Test Stand, an EUVL alpha tool, consists of a condenser with six channels to provide an effective partial coherence factor of 0.7. The camera contains four mirrors; three of the mirrors are aspheres and the fourth is spherical. The design of the optical package has been constrained so that the angles of incidence and the variations in the angle of incidence of all rays allow for uniform multilayer coatings. The multilayers introduce a slight shift in image position and magnification. We have shown that a system aligned with visible light is also aligned at 13.4 nm. Each mirror must be fabricated with an RMS figure error of less than 0.25 nm and better than 0.2 nm RMS roughness. Optical surfaces that exceed each of these specifications individually have been fabricated. The success of EUVL requires that these specifications be met simultaneously.

  18. miR-4295 promotes cell proliferation and invasion in anaplastic thyroid carcinoma via CDKN1A

    SciTech Connect (OSTI)

    Shao, Mingchen; Geng, Yiwei; Lu, Peng; Xi, Ying; Wei, Sidong; Wang, Liuxing; Fan, Qingxia; Ma, Wang

    2015-09-04

    MicroRNAs (miRNAs) play important roles in the pathogenesis of many types of cancers by negatively regulating gene expression at posttranscriptional level. However, the role of microRNAs in anaplastic thyroid carcinoma (ATC), has remained elusive. Here, we identified that miR-4295 promotes ATC cell proliferation by negatively regulates its target gene CDKN1A. In ATC cell lines, CCK-8 proliferation assay indicated that the cell proliferation was promoted by miR-4295, while miR-4295 inhibitor significantly inhibited the cell proliferation. Transwell assay showed that miR-4295 mimics significantly promoted the migration and invasion of ATC cells, whereas miR-4295 inhibitors significantly reduced cell migration and invasion. luciferase assays confirmed that miR-4295 directly bound to the 3'untranslated region of CDKN1A, and western blotting showed that miR-4295 suppressed the expression of CDKN1A at the protein levels. This study indicated that miR-4295 negatively regulates CDKN1A and promotes proliferation and invasion of ATC cell lines. Thus, miR-4295 may represent a potential therapeutic target for ATC intervention. - Highlights: • miR-4295 mimics promote the proliferation and invasion of ATC cells. • miR-4295 inhibitors inhibit the proliferation and invasion of ATC cells. • miR-4295 targets 3′UTR of CDKN1A in ATC cells. • miR-4295 negatively regulates CDKN1A in ATC cells.

  19. Microfluidic Molecular Assay Platform for the Detection of miRNAs...

    Office of Scientific and Technical Information (OSTI)

    Article: Microfluidic Molecular Assay Platform for the Detection of miRNAs, mRNAs, Proteins, and Post-translational Modifications at Single-cell Resolution. Citation Details...

  20. LBNL: Architecture 2030 District Program and Small Commercial...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Silicon Valley City of San Jose - San Jose, CA - Arizona State University - Phoenix, AZ - Emerging 2030 Districts - Ann Arbor, MI; Detroit, MI; San Antonio, TX; Ithaca, ...

  1. Groundwater protection for the NuMI project

    SciTech Connect (OSTI)

    Wehmann, A.; Smart, W.; Menary, S.; Hylen, J.; Childress, S.

    1997-10-01

    The physics requirements for the long base line neutrino oscillation experiment MINOS dictate that the NuMI beamline be located in the aquifer at Fermilab. A methodology is described for calculating the level of radioactivation of groundwater caused by operation of this beamline. A conceptual shielding design for the 750 meter long decay pipe is investigated which would reduce radioactivation of the groundwater to below government standards. More economical shielding designs to meet these requirements are being explored. Also, information on local geology, hydrogeology, government standards, and a glossary have been included.

  2. Surface composition, microstructure and corrosion resistance of AZ31 magnesium alloy irradiated by high-intensity pulsed ion beam

    SciTech Connect (OSTI)

    Li, P., E-mail: pli@sqnc.edu.cn [Department of Physics and Information Engineering, Shangqiu Normal University, Shangqiu 476000 (China); Surface Engineering Laboratory, School of Materials Science and Engineering, Dalian University of Technology, Dalian 116024 (China); Lei, M.K., E-mail: surfeng@dlut.edu.cn [Surface Engineering Laboratory, School of Materials Science and Engineering, Dalian University of Technology, Dalian 116024 (China); Zhu, X.P. [Surface Engineering Laboratory, School of Materials Science and Engineering, Dalian University of Technology, Dalian 116024 (China)

    2011-06-15

    High-intensity pulsed ion beam (HIPIB) irradiation of AZ31 magnesium alloy is performed and electrochemical corrosion experiment of irradiated samples is carried out by using potentiodynamic polarization technology in order to explore the effect of HIPIB irradiation on corrosion resistance of magnesium alloy. The surface composition, cross-sectional morphology and microstructure are characterized by using electron probe microanalyzer, optical microscope and transmission electron microscope, respectively. The results indicated that HIPIB irradiation leads to a significant improvement in corrosion resistance of magnesium alloy, in terms of the considerable increase in both corrosion potential and pitting breakdown potential. The microstructural refinement and surface purification induced by HIPIB irradiation are responsible for the improved corrosion resistance. - Research Highlights: {yields} A modified layer about 30 {mu}m thick is obtained by HIPIB irradiation. {yields} Selective ablation of element/impurity phase having lower melting point is observed. {yields} More importantly, microstructural refinement occurred on the irradiated surface. {yields} The modified layer exhibited a significantly improved corrosion resistance. {yields} Improved corrosion resistance is ascribed to the combined effect induced by HIPIB.

  3. Microstructure formation in partially melted zone during gas tungsten arc welding of AZ91 Mg cast alloy

    SciTech Connect (OSTI)

    Zhu Tianping Chen, Zhan W.; Gao Wei

    2008-11-15

    During gas tungsten arc (GTA) welding of AZ91 Mg cast alloy, constitutional liquid forms locally in the original interdendritic regions in the partially melted zone (PMZ). The PMZ re-solidification behaviour has not been well understood. In this study, the gradual change of the re-solidification microstructure within PMZ from base metal side to weld metal side was characterised. High cooling rate experiments using Gleeble thermal simulator were also conducted to understand the morphological change of the {alpha}-Mg/{beta}-Mg{sub 17}Al{sub 12} phase interface formed during re-solidification after partial melting. It was found that the original partially divorced eutectic structure has become a more regular eutectic phase in most of the PMZ, although close to the fusion boundary the re-solidified eutectic is again a divorced one. Proceeding the eutectic re-solidification, if the degree of partial melting is sufficiently high, {alpha}-Mg re-solidified with a cellular growth, resulting in a serrated interface between {alpha}-Mg and {alpha}-Mg/{beta}-Mg{sub 17}Al{sub 12} in the weld sample and between {alpha}-Mg and {beta}-Mg{sub 17}Al{sub 12} (fully divorced eutectic) in Gleeble samples. The morphological changes affected by the peak temperature and cooling rate are also explained.

  4. CESIUM REMOVAL FROM TANKS 241-AN-103 & 241-SX-105 & 241-AZ-101/102 COMPOSITE FOR TESTING IN BENCH SCALE STEAM REFORMER

    SciTech Connect (OSTI)

    DUNCAN JB; HUBER HJ

    2011-06-08

    This report documents the preparation of three actual Hanford tank waste samples for shipment to the Savannah River National Laboratory (SRNL). Two of the samples were dissolved saltcakes from tank 241-AN-103 (hereafter AN-103) and tank 241-SX-105 (hereafter SX-105); one sample was a supernate composite from tanks 241-AZ-101 and 241-AZ-102 (hereafter AZ-101/102). The preparation of the samples was executed following the test plans LAB-PLAN-10-00006, Test Plan for the Preparation of Samples from Hanford Tanks 241-SX-105, 241-AN-103, 241-AN-107, and LAB-PLN-10-00014, Test Plan for the Preparation of a Composite Sample from Hanford Tanks 241-AZ-101 and 241-AZ-102 for Steam Reformer Testing at the Savannah River National Laboratory. All procedural steps were recorded in laboratory notebook HNF-N-274 3. Sample breakdown diagrams for AN-103 and SX-105 are presented in Appendix A. The tank samples were prepared in support of a series of treatability studies of the Fluidized Bed Steam Reforming (FBSR) process using a Bench-Scale Reformer (BSR) at SRNL. Tests with simulants have shown that the FBSR mineralized waste form is comparable to low-activity waste glass with respect to environmental durability (WSRC-STI-2008-00268, Mineralization of Radioactive Wastes by Fluidized Bed Steam Reforming (FBSR): Comparisons to Vitreous Waste Forms and Pertinent Durability Testing). However, a rigorous assessment requires long-term performance data from FB SR product formed from actual Hanford tank waste. Washington River Protection Solutions, LLC (WRPS) has initiated a Waste Form Qualification Program (WP-S.2.1-20 1 0-00 1, Fluidized Bed Steam Reformer Low-level Waste Form Qualification) to gather the data required to demonstrate that an adequate FBSR mineralized waste form can be produced. The documentation of the selection process of the three tank samples has been separately reported in RPP-48824, 'Sample Selection Process for Bench-Scale Steam Reforming Treatability Studies Using

  5. Cryogenic Lifetime Studies of 130 nm and 65 nm CMOS Technologies for High-Energy Physics Experiments

    SciTech Connect (OSTI)

    Hoff, James R.; Deptuch, G. W.; Wu, Guoying; Gui, Ping

    2015-03-09

    The Long Baseline Neutrino Facility intends to use unprecedented volumes of liquid argon to fill a time projection chamber in an underground facility. Research is under way to place the electronics inside the cryostat. For reasons of efficiency and economics, the lifetimes of these circuits must be well in excess of 20 years. The principle mechanism for lifetime degradation of MOSFET devices and circuits operating at cryogenic temperatures is hot carrier degradation. Choosing a process technology that is, as much as possible, immune to such degradation and developing design techniques to avoid exposure to such damage are the goals. This, then, requires careful investigation and a basic understanding of the mechanisms that underlie hot carrier degradation and the secondary effects they cause in circuits. In this work, commercially available 130 nm and 65 nm nMOS transistors operating at cryogenic temperatures are investigated. Our results show that both technologies achieve the lifetimes required by the experiment. Minimal design changes are necessary in the case of the 130 nm process and no changes whatsoever are necessary for the 65 nm process.

  6. miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma

    SciTech Connect (OSTI)

    Zhai, Jian; Qu, Shuping; Li, Xiaowei; Zhong, Jiaming; Chen, Xiaoxia; Qu, Zengqiang; Wu, Dong

    2015-08-14

    Emerging evidence suggests that microRNAs (miRNAs) play important roles in regulating HCC development and progression; however, the mechanisms by which their specific functions and mechanisms remained to be further explored. miR-129 has been reported in gastric cancers, lung cancer and colon cancer. In this study, we disclosed a new tumor suppresser function of miR-129 in HCC. We also found the downregulation of miR-129 occurred in nearly 3/4 of the tumors examined (56/76) compared with adjacent nontumorous tissues, which was more importantly, correlated to the advanced stage and vascular invasion. We then demonstrated that miR-129 overexpression attenuated HCC cells proliferation and invasion, inducing apoptosis in vitro. Moreover, we used miR-129 antagonist and found that anti-miR-129 promoted HCC cells malignant phenotypes. Mechanistically, our further investigations revealed that miR-129 suppressed cell proliferation and invasion by targeting the 3’-untranslated region of PAK5, as well as miR-129 silencing up-regulated PAK5 expression. Moreover, miR-129 expression was inversely correlated with PAK5 expression in 76 cases of HCC samples. RNA interference of PAK5 attenuated anti-miR-129 mediated cell proliferation and invasion in HCC cells. Taken together, these results demonstrated that miR-129 suppressed tumorigenesis and progression by directly targeting PAK5, defining miR-129 as a potential treatment target for HCC. - Highlights: • Decreased of miR-129 is found in HCC and associated with advanced stage and metastasis. • miR-129 suppresses proliferation and invasion of HCC cells. • miR-129 directly targets the 3′ UTR of PAK5 and diminishes PAK5 expression. • PAK5 is involved in miR-129 mediated suppression functions.

  7. MiR-153 inhibits migration and invasion of human non-small-cell lung cancer by targeting ADAM19

    SciTech Connect (OSTI)

    Shan, Nianxi; Shen, Liangfang; Wang, Jun; He, Dan; Duan, Chaojun

    2015-01-02

    Highlights: • Decreased miR-153 and up-regulated ADAM19 are correlated with NSCLC pathology. • MiR-153 inhibits the proliferation and migration and invasion of NSCLC cells in vitro. • ADAM19 is a direct target of miR-153. • ADAM19 is involved in miR-153-suppressed migration and invasion of NSCLC cells. - Abstract: MiR-153 was reported to be dysregulated in some human cancers. However, the function and mechanism of miR-153 in lung cancer cells remains unknown. In this study, we investigated the role of miR-153 in human non-small-cell lung cancer (NSCLC). Using qRT-PCR, we demonstrated that miR-153 was significantly decreased in clinical NSCLC tissues and cell lines, and downregulation of miR-153 was significantly correlated with lymph node status. We further found that ectopic expression of miR-153 significantly inhibited the proliferation and migration and invasion of NSCLC cells in vitro, suggesting that miR-153 may be a novel tumor suppressor in NSCLC. Further integrated analysis revealed that ADAM19 is as a direct and functional target of miR-153. Luciferase reporter assay demonstrated that miR-153 directly targeted 3′UTR of ADAM19, and correlation analysis revealed an inverse correlation between miR-153 and ADAM19 mRNA levels in clinical NSCLC tissues. Knockdown of ADAM19 inhibited migration and invasion of NSCLC cells which was similar with effects of overexpression of miR-153, while overexpression of ADAM19 attenuated the function of miR-153 in NSCLC cells. Taken together, our results highlight the significance of miR-153 and ADAM19 in the development and progression of NSCLC.

  8. Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells

    SciTech Connect (OSTI)

    Li, Junxia; Shan, Fabo; Xiong, Gang; Wang, Ju-Ming; Wang, Wen-Lin; Xu, Xueqing; Bai, Yun

    2014-03-28

    Highlights: • MiR-146b promotes esophageal cancer cell proliferation. • MiR-146b inhibits esophageal cancer cell apoptosis. • C/EBPβ directly binds to miR-146b promoter conserved region. • MiR-146b is up-regulated by C/EBPβ LAP2 transcriptional activation. - Abstract: Recent clinical study indicated that up-regulation of miR-146b was associated with poor overall survival of patients in esophageal squamous cell carcinoma. However, the underlying mechanism of miR-146b dysregulation remains to be explored. Here we report that miR-146b promotes cell proliferation and inhibits cell apoptosis in esophageal cancer cell lines. Mechanismly, two C/EBPβ binding motifs are located in the miR-146b promoter conserved region. Among the three isoforms of C/EBPβ, C/EBPβ LAP2 positively regulated miR-146b expression and increases miR-146b levels in a dose-dependent manner through transcription activation of miR-146b gene. Together, these results suggest a miR-146b regulatory mechanism involving C/EBPβ, which may contribute to the up-regulation of miR-146b in esophageal squamous cell carcinoma.

  9. Sandia, the Atlantic Council, and NM Water Resource Research Institute

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sponsor Roundtable on Western Water Scarcity the Atlantic Council, and NM Water Resource Research Institute Sponsor Roundtable on Western Water Scarcity - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy

  10. NNSA administrator shows NM congressional delegation the Albuquerque

    National Nuclear Security Administration (NNSA)

    Complex to make case for new facility | National Nuclear Security Administration | (NNSA) administrator shows NM congressional delegation the Albuquerque Complex to make case for new facility Friday, February 26, 2016 - 1:42pm WASHINGTON, DC - Lt. Gen. Frank Klotz (Ret.), Administrator of the Department of Energy's National Nuclear Security Administration, hosted two members of the New Mexico congressional delegation on Feb. 18 for a tour of the aging facilities occupied by 1,200 NNSA

  11. Photoelectron Emission Studies in CsBr at 257 nm

    SciTech Connect (OSTI)

    Maldonado, Juan R.; Liu, Zhi; Sun, Yun; Pianetta, Piero A.; Pease, Fabian W.; /Stanford U., Elect. Eng. Dept. /SLAC, SSRL

    2006-09-28

    CsBr/Cr photocathodes were found [1,2] to meet the requirements of a multi-electron beam lithography system operating with a light energy of 4.8 eV (257nm). The fact that photoemission was observed with a light energy below the reported 7.3 eV band gap for CsBr was not understood. This paper presents experimental results on the presence of intra-band gap absorption sites (IBAS) in CsBr thin film photo electron emitters, and presents a model based on IBAS to explain the observed photoelectron emission behavior at energies below band gap. A fluorescence band centered at 330 nm with a FWHM of about 0.34 eV was observed in CsBr/Cr samples under 257 nm laser illumination which can be attributed to IBAS and agrees well with previously obtained synchrotron photoelectron spectra[1] from the valence band of CsBr films.

  12. miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2

    SciTech Connect (OSTI)

    Fu, Jing; Xu, Xiaojie; Kang, Lei; Zhou, Liying; Wang, Shibin; Lu, Juming; Cheng, Long; Fan, Zhongyi; Yuan, Bin; Tian, Peirong; Zheng, Xiaofei; Yu, Chengze; Ye, Qinong; Lv, Zhaohui

    2014-03-07

    Highlights: • miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. • The miR-30a/EYA2 axis regulates breast cancer cell proliferation and migration. • The miR-30a/EYA2 axis modulates G1/S cell cycle progression. • The miR-30a/EYA2 axis is dysregulated in breast cancer patients. - Abstract: Eye absent (Eya) proteins are involved in cell fate determination in a broad spectrum of cells and tissues. Aberrant expression of Eya2 has been documented in a variety of cancers and correlates with clinical outcome. However, whether microRNAs (miRNAs) can regulate Eya2 expression remains unknown. Here, we show that miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2. Overexpression of Eya2 in miR-30a-transfected breast cancer cells effectively rescued the inhibition of cell proliferation and migration caused by miR-30a. Knockdown of Eya2 by small-interfering RNA (siRNA) in breast cancer cells mimicked the effect induced by miR-30a and abolished the ability of miR-30a to regulate breast cancer cell proliferation and migration. The miR-30a/Eya2 axis could regulate G1/S cell cycle progression, accompanied by the modulation of expression of cell cycle-related proteins, including cyclin A, cyclin D1, cyclin E, and c-Myc. Moreover, miR-30a expression was downregulated in breast cancer patients, and negatively correlated with Eya2, which was upregulated in breast cancer patients. These data suggest that the miR-30a/Eya2 axis may play an important role in breast cancer development and progression and that miR-30a activation or Eya2 inhibition may be a useful strategy for cancer treatment.

  13. miR-92a is upregulated in cervical cancer and promotes cell proliferation and invasion by targeting FBXW7

    SciTech Connect (OSTI)

    Zhou, Chuanyi; Shen, Liangfang; Mao, Lei; Wang, Bing; Li, Yang; Yu, Huizhi

    2015-02-27

    MicroRNAs (miRNAs) are involved in the cervical carcinogenesis and progression. In this study, we investigated the role of miR-92a in progression and invasion of cervical cancer. MiR-92a was significantly upregulated in cervical cancer tissues and cell lines. Overexpression of miR-92a led to remarkably enhanced proliferation by promoting cell cycle transition from G1 to S phase and significantly enhanced invasion of cervical cancer cells, while its knockdown significantly reversed these cellular events. Bioinformatics analysis suggested F-box and WD repeat domain-containing 7 (FBXW7) as a novel target of miR-92a, and miR-92a suppressed the expression level of FBXW7 mRNA by direct binding to its 3′-untranslated region (3′UTR). Expression of miR-92a was negatively correlated with FBXW7 in cervical cancer tissues. Furthermore, Silencing of FBXW7 counteracted the effects of miR-92a suppression, while its overexpression reversed oncogenic effects of miR-92a. Together, these findings indicate that miR-92a acts as an onco-miRNA and may contribute to the progression and invasion of cervical cancer, suggesting miR-92a as a potential novel diagnostic and therapeutic target of cervical cancer. - Highlights: • miR-92a is elevated in cervical cancer tissues and cell lines. • miR-92a promotes cervical cancer cell proliferation, cell cycle transition from G1 to S phase and invasion. • FBXW7 is a direct target of miR-92a. • FBXW7 counteracts the oncogenic effects of miR-92a on cervical cancer cells.

  14. miR-182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma

    SciTech Connect (OSTI)

    Zhu, Hongling; Fang, Jin; Zhang, Jichen; Zhao, Zefei; Liu, Lianyong; Wang, Jingnan; Xi, Qian; Gu, Mingjun

    2014-07-18

    Highlights: miR-182 and CHL1 expression patterns are negatively correlated. CHL1 is a direct target of miR-182 in PTC cells. miR-182 suppression inhibits PTC cell growth and invasion. CHL1 is involved in miR-182-mediated cell behavior. - Abstract: In this study, we investigated the role and underlying mechanism of action of miR-182 in papillary thyroid carcinoma (PTC). Bioinformatics analysis revealed close homolog of LI (CHL1) as a potential target of miR-182. Upregulation of miR-182 was significantly correlated with CHL1 downregulation in human PTC tissues and cell lines. miR-182 suppressed the expression of CHL1 mRNA through direct targeting of the 3?-untranslated region (3?-UTR). Downregulation of miR-182 suppressed growth and invasion of PTC cells. Silencing of CHL1 counteracted the effects of miR-182 suppression, while its overexpression mimicked these effects. Our data collectively indicate that miR-182 in PTC promotes cell proliferation and invasion through direct suppression of CHL1, supporting the potential utility of miR-182 inhibition as a novel therapeutic strategy against PTC.

  15. Non-canonical microRNAs miR-320 and miR-702 promote proliferation in Dgcr8-deficient embryonic stem cells

    SciTech Connect (OSTI)

    Kim, Byeong-Moo; Choi, Michael Y.

    2012-09-21

    Highlights: Black-Right-Pointing-Pointer Embryonic stem cells (ESCs) lacking non-canonical miRNAs proliferate slower. Black-Right-Pointing-Pointer miR-320 and miR-702 are two non-canonical miRNAs expressed in ESCs. Black-Right-Pointing-Pointer miR-320 and miR-702 promote proliferation of Dgcr8-deficient ESCs. Black-Right-Pointing-Pointer miR-320 targets p57 and helps to release Dgcr8-deficient ESCs from G1 arrest. Black-Right-Pointing-Pointer miR-702 targets p21 and helps to release Dgcr8-deficient ESCs from G1 arrest. -- Abstract: MicroRNAs are known to contribute significantly to stem cell phenotype by post-transcriptionally regulating gene expression. Most of our knowledge of microRNAs comes from the study of canonical microRNAs that require two sequential cleavages by the Drosha/Dgcr8 heterodimer and Dicer to generate mature products. In contrast, non-canonical microRNAs bypass the cleavage by the Drosha/Dgcr8 heterodimer within the nucleus but still require cytoplasmic cleavage by Dicer. The function of non-canonical microRNAs in embryonic stem cells (ESCs) remains obscure. It has been hypothesized that non-canonical microRNAs have important roles in ESCs based upon the phenotypes of ESC lines that lack these specific classes of microRNAs; Dicer-deficient ESCs lacking both canonical and non-canonical microRNAs have much more severe proliferation defect than Dgcr8-deficient ESCs lacking only canonical microRNAs. Using these cell lines, we identified two non-canonical microRNAs, miR-320 and miR-702, that promote proliferation of Dgcr8-deficient ESCs by releasing them from G1 arrest. This is accomplished by targeting the 3 Prime -untranslated regions of the cell cycle inhibitors p57 and p21 and thereby inhibiting their expression. This is the first report of the crucial role of non-canonical microRNAs in ESCs.

  16. NuMI proton kicker extraction magnet termination resistor system

    SciTech Connect (OSTI)

    Reeves, S.R.; Jensen, C.C.; /Fermilab

    2005-05-01

    The temperature stability of the kicker magnet termination resistor assembly directly affects the field flatness and amplitude stability. Comprehensive thermal enhancements were made to the existing Main Injector resistor assembly design to satisfy NuMI performance specifications. Additionally, a fluid-processing system utilizing Fluorinert{reg_sign} FC-77 high-voltage dielectric was built to precisely control the setpoint temperature of the resistor assembly from 70 to 120F, required to maintain constant resistance during changing operational modes. The Fluorinert{reg_sign} must be continually processed to remove hazardous breakdown products caused by radiation exposure to prevent chemical attack of system components. Design details of the termination resistor assembly and Fluorinert{reg_sign} processing system are described. Early performance results will be presented.

  17. Downregulation of miRNA-30c and miR-203a is associated with hepatitis C virus core protein-induced epithelial–mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cells

    SciTech Connect (OSTI)

    Liu, Dongjing; Wu, Jilin; Liu, Meizhou; Yin, Hui; He, Jiantai; Zhang, Bo

    2015-09-04

    Hepatitis C virus (HCV) Core protein has been demonstrated to induce epithelial–mesenchymal transition (EMT) and is associated with cancer progression of hepatocellular carcinoma (HCC). However, how the Core protein regulates EMT is still unclear. In this study, HCV Core protein was overexpressed by an adenovirus. The protein levels of EMT markers were measured by Western blot. The xenograft animal model was established by inoculation of HepG2 cells. Results showed that ectopic expression of HCV core protein induced EMT in L02 hepatocytes and HepG2 tumor cells by upregulating vimentin, Sanl1, and Snal2 expression and downregulating E-cadherin expression. Moreover, Core protein downregulated miR-30c and miR-203a levels in L02 and HepG2 cells, but artificial expression of miR-30c and miR-203a reversed Core protein-induced EMT. Further analysis showed that ectopic expression of HCV core protein stimulated cell proliferation, inhibited apoptosis, and increased cell migration, whereas artificial expression of miR-30c and miR-203a significantly reversed the role of Core protein in these cell functions in L02 and HepG2 cells. In the HepG2 xenograft tumor models, artificial expression of miR-30c and miR-203a inhibited EMT and tumor growth. Moreover, L02 cells overexpressing Core protein can form tumors in nude mice. In HCC patients, HCV infection significantly shortened patients' survival time, and loss of miR-30c and miR-203 expression correlated with poor survival. In conclusion, HCV core protein downregulates miR-30c and miR-203a expression, which results in activation of EMT in normal hepatocytes and HCC tumor cells. The Core protein-activated-EMT is involved in the carcinogenesis and progression of HCC. Loss of miR-30c and miR-203a expression is a marker for the poor prognosis of HCC. - Highlights: • HCV core protein downregulates miR-30c and miR-203a expression. • Downregulation of miR-30c and miR-203a activates EMT. • Activated-EMT is involved in the

  18. miR-128 and its target genes in tumorigenesis and metastasis

    SciTech Connect (OSTI)

    Li, Molin, E-mail: molin_li@hotmail.com [Dalian Medical University, Dalian 116044 (China); Fu, Weiming [Center for Food Safety and Environmental Technology, Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou 511458 (China); Wo, Lulu; Shu, Xiaohong [Dalian Medical University, Dalian 116044 (China); Liu, Fang [The second affiliated hospital of Dalian Medical University, Dalian 116023 (China); Li, Chuangang, E-mail: li_chuangang@sina.com [The second affiliated hospital of Dalian Medical University, Dalian 116023 (China)

    2013-12-10

    MicroRNAs (miRNAs) are a class of endogenous, non-coding, 1824 nucleotide length single-strand RNAs that could modulate gene expression at post-transcriptional level. Previous studies have shown that miR-128 enriched in the brain plays an important role in the development of nervous system and the maintenance of normal physical functions. Aberrant expression of miR-128 has been detected in many types of human tumors and its validated target genes are involved in cancer-related biological processes such as cell proliferation, differentiation and apoptosis. In this review, we will summarize the roles of miR-128 and its target genes in tumorigenesis and metastasis. - Highlights: Aberrant expression of miR-128 can be observed in many kinds of malignant tumors. The molecular mechanisms regulating miR-128 expression are elucidated. Roles of miR-128 and its target genes in tumorigenesis and metastasis are summarized.

  19. miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation

    SciTech Connect (OSTI)

    Mizuno, Yosuke; Yagi, Ken; Tokuzawa, Yoshimi; Kanesaki-Yatsuka, Yukiko; Suda, Tatsuo; Katagiri, Takenobu; Fukuda, Toru; Maruyama, Masayoshi; Okuda, Akihiko; Amemiya, Tomoyuki; Kondoh, Yasumitsu; Tashiro, Hideo; Okazaki, Yasushi

    2008-04-04

    Although various microRNAs regulate cell differentiation and proliferation, no miRNA has been reported so far to play an important role in the regulation of osteoblast differentiation. Here we describe the role of miR-125b in osteoblastic differentiation in mouse mesenchymal stem cells, ST2, by regulating cell proliferation. The expression of miR-125b was time-dependently increased in ST2 cells, and the increase in miR-125b expression was attenuated in osteoblastic-differentiated ST2 cells induced by BMP-4. The transfection of exogenous miR-125b inhibited proliferation of ST2 cells and caused inhibition of osteoblastic differentiation. In contrast, when the endogenous miR-125b was blocked by transfection of its antisense RNA molecule, alkaline phosphatase activity after BMP-4 treatment was elevated. These results strongly suggest that miR-125b is involved in osteoblastic differentiation through the regulation of cell proliferation.

  20. Pollution Prevention Opportunity Assessment for the SNL/NM cafeterias.

    SciTech Connect (OSTI)

    McCord, Samuel Adam

    2005-12-01

    This Pollution Prevention Opportunity Assessment (PPOA) was conducted for the two Sandia National Laboratories/New Mexico cafeteria facilities between May and August 2005. The primary purpose of this PPOA is to assess waste and resource reduction opportunities and issue Pollution Prevention (P2) recommendations for Sandia's food service facilities. This PPOA contains recommendations for energy, water and resource reduction, as well as material substitution based upon environmentally preferable purchasing. Division 3000 has requested the PPOA report as part of the Division's compliance effort to implement the Environmental Management System (EMS) per DOE Order 450.1. This report contains a summary of the information collected and analyses performed with recommended options for implementation. The SNL/NM P2 Group will work with Division 3000 and the respective cafeteria facilities to implement these options.

  1. Nanobumps on silicon created with polystyrene spheres and 248 or 308 nm laser pulses

    SciTech Connect (OSTI)

    Piparia, Reema; Rothe, Erhard W.; Baird, R. J.

    2006-11-27

    Huang et al. [Appl. Phys. Lett. 86, 161911 (2005)] formed arrays of nanobumps on a silicon substrate. They applied a 248 nm laser pulse to a surface monolayer of 1-{mu}m-diameter polystyrene spheres. The authors first replicated their experiment with 248 nm light. But when 308 nm pulses were applied instead, the nanobumps had a different shape and composition. At 248 nm, much of the laser light is absorbed in the polystyrene, which serves to quickly distort, melt, and ablate the sphere. At 308 nm, very little light is absorbed. The nanobumps from 248 nm radiation are organic polymers, while those formed with 308 nm pulses are silicon based.

  2. DOE - Office of Legacy Management -- LASL Tracks Eastern Area No 3 - NM 10

    Office of Legacy Management (LM)

    Tracks Eastern Area No 3 - NM 10 FUSRAP Considered Sites Site: LASL TRACKS EASTERN AREA NO. 3 (NM.10 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: Area No. 3 , Los Alamos County , New Mexico NM.10-1 Evaluation Year: 1987 NM.10-2 Site Operations: These tracts were part of LASL and were subject to contamination from laboratory operations. NM.10-2 Site Disposition: Eliminated - Radiation levels below criteria per environmental radiation

  3. Overexpression of miR-206 suppresses glycolysis, proliferation and migration in breast cancer cells via PFKFB3 targeting

    SciTech Connect (OSTI)

    Ge, Xin; Lyu, Pengwei; Cao, Zhang; Li, Jingruo; Guo, Guangcheng; Xia, Wanjun; Gu, Yuanting

    2015-08-07

    miRNAs, sorting as non-coding RNAs, are differentially expressed in breast tumor and act as tumor promoters or suppressors. miR-206 could suppress the progression of breast cancer, the mechanism of which remains unclear. The study here was aimed to investigate the effect of miR-206 on human breast cancers. We found that miR-206 was down-regulated while one of its predicted targets, 6-Phosphofructo-2-kinase (PFKFB3) was up-regulated in human breast carcinomas. 17β-estradiol dose-dependently decreased miR-206 expression as well as enhanced PFKFB3 mRNA and protein expression in estrogen receptor α (ERα) positive breast cancer cells. Furthermore, we identified that miR-206 directly interacted with 3′-untranslated region (UTR) of PFKFB3 mRNA. miR-206 modulated PFKFB3 expression in MCF-7, T47D and SUM159 cells, which was influenced by 17β-estradiol depending on ERα expression. In addition, miR-206 overexpression impeded fructose-2,6-bisphosphate (F2,6BP) production, diminished lactate generation and reduced cell proliferation and migration in breast cancer cells. In conclusion, our study demonstrated that miR-206 regulated PFKFB3 expression in breast cancer cells, thereby stunting glycolysis, cell proliferation and migration. - Highlights: • miR-206 was down-regulated and PFKFB3 was up-regulated in human breast carcinomas. • 17β-estradiol regulated miR-206 and PFKFB3 expression in ERα+ cancer cells. • miR-206directly interacted with 3′-UTR of PFKFB3 mRNA. • miR-206 fructose-2,6-bisphosphate (F2,6BP) impeded production and lactate generation. • miR-206 reduced cell proliferation and migration in breast cancer cells.

  4. AMENDMENT OF SOLICITATION/MODIFICATlON OF CONTRACT MI54 I See...

    National Nuclear Security Administration (NNSA)

    MI54 I See Block 16C I REQ. NO. Babcock & Wilcox Technical Services Pantex, LLC PO Box 30020 Amarillo, TX 79120 2. AMENDMENTIMODIFICATION NO. 1 3. EFFECTIVE DATE 1 4. ...

  5. File:USDA-CE-Production-GIFmaps-MI.pdf | Open Energy Information

    Open Energy Info (EERE)

    MI.pdf Jump to: navigation, search File File history File usage Michigan Ethanol Plant Locations Size of this preview: 463 599 pixels. Other resolution: 464 600 pixels. Full...

  6. Climate Action Champions: Sault Ste. Marie Tribe of Chippewa Indians, MI |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Sault Ste. Marie Tribe of Chippewa Indians, MI Climate Action Champions: Sault Ste. Marie Tribe of Chippewa Indians, MI The Sault Ste. Marie Tribe of Chippewa Indians is a 44,000-strong federally recognized Indian tribe that is an economic, social and cultural force in its community across the eastern Upper Peninsula counties of Chippewa, Luce, Mackinac, Schoolcraft, Alger, Delta and Marquette, with housing and tribal centers, casinos, and other enterprises that employ

  7. FY09 assessment of mercury reduction at SNL/NM.

    SciTech Connect (OSTI)

    McCord, Samuel Adam

    2010-02-01

    This assessment takes the result of the FY08 performance target baseline of mercury at Sandia National Laboratories/New Mexico, and records the steps taken in FY09 to collect additional data, encourage the voluntary reduction of mercury, and measure success. Elemental (metallic) mercury and all of its compounds are toxic, and exposure to excessive levels can permanently damage or fatally injure the brain and kidneys. Elemental mercury can also be absorbed through the skin and cause allergic reactions. Ingestion of inorganic mercury compounds can cause severe renal and gastrointestinal damage. Organic compounds of mercury such as methyl mercury, created when elemental mercury enters the environment, are considered the most toxic forms of the element. Exposures to very small amounts of these compounds can result in devastating neurological damage and death.1 SNL/NM is required to report annually on the site wide inventory of mercury for the Environmental Protection Agency's (EPA) Toxics Release Inventory (TRI) Program, as the site's inventory is excess of the ten pound reportable threshold quantity. In the fiscal year 2008 (FY08) Pollution Prevention Program Plan, Section 5.3 Reduction of Environmental Releases, a performance target stated was to establish a baseline of mercury, its principle uses, and annual quantity or inventory. This was accomplished on July 29, 2008 by recording the current status of mercury in the Chemical Information System (CIS).

  8. AZ Automotive: Presentation

    Broader source: Energy.gov [DOE]

    The role of midsize automotive module suppliers in meeting the goals of the Energy Independence and Security act of 2007

  9. Ion Exclusion by Sub 2-nm Carbon Nanotube Pores

    SciTech Connect (OSTI)

    Fornasiero, F; Park, H G; Holt, J K; Stadermann, M; Grigoropoulos, C P; Noy, A; Bakajin, O

    2008-04-09

    Carbon nanotubes offer an outstanding platform for studying molecular transport at nanoscale, and have become promising materials for nanofluidics and membrane technology due to their unique combination of physical, chemical, mechanical, and electronic properties. In particular, both simulations and experiments have proved that fluid flow through carbon nanotubes of nanometer size diameter is exceptionally fast compared to what continuum hydrodynamic theories would predict when applied on this length scale, and also, compared to conventional membranes with pores of similar size, such as zeolites. For a variety of applications such as separation technology, molecular sensing, drug delivery, and biomimetics, selectivity is required together with fast flow. In particular, for water desalination, coupling the enhancement of the water flux with selective ion transport could drastically reduce the cost of brackish and seawater desalting. In this work, we study the ion selectivity of membranes made of aligned double-walled carbon nanotubes with sub-2 nm diameter. Negatively charged groups are introduced at the opening of the carbon nanotubes by oxygen plasma treatment. Reverse osmosis experiments coupled with capillary electrophoresis analysis of permeate and feed show significant anion and cation rejection. Ion exclusion declines by increasing ionic strength (concentration) of the feed and by lowering solution pH; also, the highest rejection is observed for the A{sub m}{sup Z{sub A}} C{sub n}{sup Z{sub C}} salts (A=anion, C=cation, z= valence) with the greatest Z{sub A}/Z{sub C} ratio. Our results strongly support a Donnan-type rejection mechanism, dominated by electrostatic interactions between fixed membrane charges and mobile ions, while steric and hydrodynamic effects appear to be less important. Comparison with commercial nanofiltration membranes for water softening reveals that our carbon nanotube membranes provides far superior water fluxes for similar ion

  10. miR-196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells

    SciTech Connect (OSTI)

    Zhang, Jie; Zheng, Fangxia; Yu, Gang; Yin, Yanhua; Lu, Qingyang

    2013-11-01

    Highlights: miR-196a was overexpressed in cervical cancer tissue compared to normal tissue. miR-196a expression elevated proliferation and migration of cervical cancer cells. miR-196a inhibited NTN4 expression by binding 3?-UTR region of NTN4 mRNA. NTN4 inversely correlated with miR-196a expression in cervical tissue and cell line. NTN4 expression was low in cervical cancer tissue compared to normal tissue. -- Abstract: Recent research has uncovered tumor-suppressive and oncogenic potential of miR-196a in various tumors. However, the expression and mechanism of its function in cervical cancer remains unclear. In this study, we assess relative expression of miR-196a in cervical premalignant lesions, cervical cancer tissues, and four cancer cell lines using quantitative real-time PCR. CaSki and HeLa cells were treated with miR-196a inhibitors, mimics, or pCDNA/miR-196a to investigate the role of miR-196a in cancer cell proliferation and migration. We demonstrated that miR-196a was overexpressed in cervical intraepithelial neoplasia 23 and cervical cancer tissue. Moreover, its expression contributes to the proliferation and migration of cervical cancer cells, whereas inhibiting its expression led to a reduction in proliferation and migration. Five candidate targets of miR-196a chosen by computational prediction and Cervical Cancer Gene Database search were measured for their mRNA in both miR-196a-overexpressing and -depleted cancer cells. Only netrin 4 (NTN4) expression displayed an inverse association with miR-196a. Fluorescent reporter assays revealed that miR-196a inhibited NTN4 expression by targeting one binding site in the 3?-untranslated region (3?-UTR) of NTN4 mRNA. Furthermore, qPCR and Western blot assays verified NTN4 expression was downregulated in cervical cancer tissues compared to normal controls, and in vivo mRNA level of NTN4 inversely correlated with miR-196a expression. In summary, our findings provide new insights about the functional role of

  11. Double patterning HSQ processes of zone plates for 10 nm diffraction...

    Office of Scientific and Technical Information (OSTI)

    ... Using the new process, we successfully realized zone plates of 10 nm and 12 nm outermost zones. Fig. 3 shows the SEM micrographs of the zone plates outer regions. The zone plates ...

  12. New Zone Plate for Soft X-Ray Microscopy at 15-nm Spatial Resolution

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    New Zone Plate for Soft X-Ray Microscopy at 15-nm Spatial Resolution New Zone Plate for Soft X-Ray Microscopy at 15-nm Spatial Resolution Print Wednesday, 31 August 2005 00:00 ...

  13. NM Stat. 62-11 - Review of Commission Orders | Open Energy Information

    Open Energy Info (EERE)

    NM Stat. 62-11 - Review of Commission Orders Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- StatuteStatute: NM Stat. 62-11 - Review of...

  14. Transport of triplet excitons along continuous 100 nm polyfluorene chains

    SciTech Connect (OSTI)

    Xi, Liang; Bird, Matthew; Mauro, Gina; Asaoka, Sadayuki; Cook, Andrew R.; Chen, Hung -Cheng; Miller, John R.

    2014-12-03

    Triplet excitons created in poly-2,7-(9,9-dihexyl)fluorene (pF) chains with end trap groups in solution are efficiently transported to and captured by the end groups. The triplets explore the entire lengths of the chains, even for ~100 nm long chains enabling determination of the completeness of end capping. The results show that the chains continuous: they may contain transient barriers or traps, such as those from fluctuations of dihedral angles, but are free of major defects that stop motion of the triplets. Quantitative determinations are aided by the addition of a strong electron donor, TMPD, which removes absorption bands of the end-trapped triplets. For chains having at least one end trap, triplet capture is quantitative on the 1 s timescale imposed by the use of the donor. Fractions of chains having no end traps were 0.15 for pF samples with anthraquinone (AQ) end traps and 0.063 with naphthylimide (NI) end traps. These determinations agreed with measurements by NMR for short (<40 polymer repeat units (PRU)) chains, where NMR determinations are accurate. The results find no evidence for traps or barriers to transport of triplets, and places limits on the possible presence of defects as impenetrable barriers to less than one per 300 PRU. The present results present a paradigm different from the current consensus, derived from observations of singlet excitons, that conjugated chains are divided into segments, perhaps by some kind of defects. For the present pF chains, the segmentation either does not apply to triplet excitons or is transient so that the defects are healed or surmounted in times much shorter than 1 s. Triplets on chains without end trap groups transfer to chains with end traps on a slower time scale. Rate constants for these bimolecular triplet transfer reactions were found to increase with the length of the accepting chain, as did rate constants for triplet transfer to the chains from small molecules like biphenyl. As a result, a second

  15. Transport of triplet excitons along continuous 100 nm polyfluorene chains

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Xi, Liang; Bird, Matthew; Mauro, Gina; Asaoka, Sadayuki; Cook, Andrew R.; Chen, Hung -Cheng; Miller, John R.

    2014-12-03

    Triplet excitons created in poly-2,7-(9,9-dihexyl)fluorene (pF) chains with end trap groups in solution are efficiently transported to and captured by the end groups. The triplets explore the entire lengths of the chains, even for ~100 nm long chains enabling determination of the completeness of end capping. The results show that the chains continuous: they may contain transient barriers or traps, such as those from fluctuations of dihedral angles, but are free of major defects that stop motion of the triplets. Quantitative determinations are aided by the addition of a strong electron donor, TMPD, which removes absorption bands of the end-trappedmore » triplets. For chains having at least one end trap, triplet capture is quantitative on the 1 µs timescale imposed by the use of the donor. Fractions of chains having no end traps were 0.15 for pF samples with anthraquinone (AQ) end traps and 0.063 with naphthylimide (NI) end traps. These determinations agreed with measurements by NMR for short (<40 polymer repeat units (PRU)) chains, where NMR determinations are accurate. The results find no evidence for traps or barriers to transport of triplets, and places limits on the possible presence of defects as impenetrable barriers to less than one per 300 PRU. The present results present a paradigm different from the current consensus, derived from observations of singlet excitons, that conjugated chains are divided into “segments,” perhaps by some kind of defects. For the present pF chains, the segmentation either does not apply to triplet excitons or is transient so that the defects are healed or surmounted in times much shorter than 1 µs. Triplets on chains without end trap groups transfer to chains with end traps on a slower time scale. Rate constants for these bimolecular triplet transfer reactions were found to increase with the length of the accepting chain, as did rate constants for triplet transfer to the chains from small molecules like biphenyl. As a

  16. miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1

    SciTech Connect (OSTI)

    Xu, Zhengyu; Wang, Tao

    2014-06-27

    Highlights: • miR-214 is upregulated in human OS tissues and inversely correlated with LZTS1 expression. • miR-214 directly targets LZTS1 by binding to its 3′-UTR. • miR-214 promotes OS cell proliferation, invasion and tumor growth. • Overexpression of LZTS1 reverses miR-214-induced proliferation and invasion of OS cells. - Abstract: Previous studies have shown that miR-214 functions either as an oncogene or a tumor suppressor in various human cancer types. The role of this microRNA in osteosarcoma (OS) is presently unclear. Here, we demonstrated that miR-214 is frequently upregulated in OS specimens, compared with noncancerous bone tissues. Bioinformatics analysis further revealed leucine zipper, putative tumor suppressor 1 (LZTS1) as a potential target of miR-214. Expression patterns of miR-214 were inversely correlated with those of LZTS1 mRNA and protein in OS tissues. Data from reporter assays showed that miR-214 directly binds to the 3′-untranslated region (3′-UTR) of LZTS1 mRNA and suppresses expression at both transcriptional and translational levels. In functional assays, miR-214 promoted OS cell proliferation, invasion and tumor growth in nude mice, which could be reversed by overexpression of LZTS1. Taken together, our data provide compelling evidence that miR-214 functions as an onco-miRNA in OS, and its oncogenic effects are mediated chiefly through downregulation of LZTS1.

  17. The Role of Friction Stir Welding on the Microstructure and Mechanical Properties of AZ31B-H24 Mg alloy

    SciTech Connect (OSTI)

    Darzi, Kh.; Saeid, T. [Advanced Materials Research Center - Faculty of Materials Engineering, Sahand University of Technology - Tabriz (Iran, Islamic Republic of)

    2011-12-26

    In this study, an attempt was made to join AZ31B magnesium alloy by friction stir welding (FSW) process. A single tool with cylindrical screw threaded pin was used to investigate the effect of welding parameters on microstructure and mechanical properties of stir zone (SZ). Several welds were made at different rotational ({omega}) and traverse ({upsilon}) speeds, while the {omega}/{upsilon} ratios were kept constant. The optical and scanning electron microscopy were used to study the variation of microstructure across the welds. Moreover, micro-hardness and tensile tests were carried out to evaluate the mechanical properties of joints. It was found that {omega} plays more significant role on the resulted grain structure than {upsilon}, and at a constant {omega}/{upsilon} ratio, decreasing rotational speed decreased the size of grains, and hence, improved the hardness value and the tensile strength of the SZ.

  18. miR-421 induces cell proliferation and apoptosis resistance in human nasopharyngeal carcinoma via downregulation of FOXO4

    SciTech Connect (OSTI)

    Chen, Liang; Department of Otolaryngology, Guangzhou General Hospital of PLA Guangzhou Command, Guangzhou 510010 ; Tang, Yanping; Wang, Jian; Yan, Zhongjie; Xu, Ruxiang

    2013-06-14

    Highlights: •miR-421 is upregulated in nasopharyngeal carcinoma. •miR-421 induces cell proliferation and apoptosis resistance. •FOXO4 is a direct and functional target of miR-421. -- Abstract: microRNAs have been demonstrated to play important roles in cancer development and progression. Hence, identifying functional microRNAs and better understanding of the underlying molecular mechanisms would provide new clues for the development of targeted cancer therapies. Herein, we reported that a microRNA, miR-421 played an oncogenic role in nasopharyngeal carcinoma. Upregulation of miR-421 induced, whereas inhibition of miR-421 repressed cell proliferation and apoptosis resistance. Furthermore, we found that upregulation of miR-421 inhibited forkhead box protein O4 (FOXO4) signaling pathway following downregulation of p21, p27, Bim and FASL expression by directly targeting FOXO4 3′UTR. Additionally, we demonstrated that FOXO4 expression is critical for miR-421-induced cell growth and apoptosis resistance. Taken together, our findings not only suggest that miR-421 promotes nasopharyngeal carcinoma cell proliferation and anti-apoptosis, but also uncover a novel regulatory mechanism for inactivation of FOXO4 in nasopharyngeal carcinoma.

  19. Roles of miRNAs in microcystin-LR-induced Sertoli cell toxicity

    SciTech Connect (OSTI)

    Zhou, Yuan; Wang, Hui; Wang, Cong; Qiu, Xuefeng; Benson, Mikael; Yin, Xiaoqin; Xiang, Zou; Li, Dongmei; and others

    2015-08-15

    Microcystin (MC)-LR, a cyclic heptapeptide, is a potent reproductive system toxin. To understand the molecular mechanisms of MC-induced reproductive system cytotoxicity, we evaluated global changes of miRNA and mRNA expression in mouse Sertoli cells following MC-LR treatment. Our results revealed that the exposure to MC-LR resulted in an altered miRNA expression profile that might be responsible for the modulation of mRNA expression. Bio-functional analysis indicated that the altered genes were involved in specific cellular processes, including cell death and proliferation. Target gene analysis suggested that junction injury in Sertoli cells exposed to MC-LR might be mediated by miRNAs through the regulation of the Sertoli cell-Sertoli cell pathway. Collectively, these findings may enhance our understanding on the modes of action of MC-LR on mouse Sertoli cells as well as the molecular mechanisms underlying the toxicity of MC-LR on the male reproductive system. - Highlights: • miRNAs were altered in Sertoli cells exposed to MC-LR. • Alerted genes were involved in different cell functions including the cell morphology. • MC-LR adversely affected Sertoli cell junction formation through the regulating miRNAs.

  20. DOE - Office of Legacy Management -- LASL Land Parcels A B C E K LN PL - NM

    Office of Legacy Management (LM)

    07 Land Parcels A B C E K LN PL - NM 07 Site ID (CSD Index Number): NM.09 Site Name: LOS ALAMOS LAND PARCELS A B C E K L N PIPELINE (NM.07) / LASL PIPELINE FACILITY (NM.08) / LASL TRACTS EASTERN AREA L Site Summary: These land parcels, previously owned by the federal government, were sold in 1972. The pipeline facility and eastern area L were identified separately in some documents and assigned individual numbers by FUSRAP researchers, but these parcels were included in NM.07. Site Link:

  1. Low-noise low-jitter 32-pixels CMOS single-photon avalanche diodes array for single-photon counting from 300 nm to 900 nm

    SciTech Connect (OSTI)

    Scarcella, Carmelo; Tosi, Alberto Villa, Federica; Tisa, Simone; Zappa, Franco

    2013-12-15

    We developed a single-photon counting multichannel detection system, based on a monolithic linear array of 32 CMOS SPADs (Complementary Metal-Oxide-Semiconductor Single-Photon Avalanche Diodes). All channels achieve a timing resolution of 100 ps (full-width at half maximum) and a photon detection efficiency of 50% at 400 nm. Dark count rate is very low even at room temperature, being about 125 counts/s for 50 ?m active area diameter SPADs. Detection performance and microelectronic compactness of this CMOS SPAD array make it the best candidate for ultra-compact time-resolved spectrometers with single-photon sensitivity from 300 nm to 900 nm.

  2. Ionizing Radiation–Inducible miR-27b Suppresses Leukemia Proliferation via Targeting Cyclin A2

    SciTech Connect (OSTI)

    Wang, Bo; Li, Dongping; Kovalchuk, Anna; Litvinov, Dmitry; Kovalchuk, Olga

    2014-09-01

    Purpose: Ionizing radiation is a common carcinogen that is important for the development of leukemia. However, the underlying epigenetic mechanisms remain largely unknown. The goal of the study was to explore microRNAome alterations induced by ionizing radiation (IR) in murine thymus, and to determine the role of IR-inducible microRNA (miRNA/miR) in the development of leukemia. Methods and Materials: We used the well-established C57BL/6 mouse model and miRNA microarray profiling to identify miRNAs that are differentially expressed in murine thymus in response to irradiation. TIB152 human leukemia cell line was used to determine the role of estrogen receptor–α (ERα) in miR-27b transcription. The biological effects of ectopic miR-27b on leukemogenesis were measured by western immunoblotting, cell viability, apoptosis, and cell cycle analyses. Results: Here, we have shown that IR triggers the differential expression of miR-27b in murine thymus tissue in a dose-, time- and sex-dependent manner. miR-27b was significantly down-regulated in leukemia cell lines CCL119 and TIB152. Interestingly, ERα was overexpressed in those 2 cell lines, and it was inversely correlated with miR-27b expression. Therefore, we used TIB152 as a model system to determine the role of ERα in miR-27b expression and the contribution of miR-27b to leukemogenesis. β-Estradiol caused a rapid and transient reduction in miR-27b expression reversed by either ERα-neutralizing antibody or ERK1/2 inhibitor. Ectopic expression of miR-27b remarkably suppressed TIB152 cell proliferation, at least in part, by inducing S-phase arrest. In addition, it attenuated the expression of cyclin A2, although it had no effect on the levels of PCNA, PPARγ, CDK2, p21, p27, p-p53, and cleaved caspase-3. Conclusion: Our data reveal that β-estradiol/ERα signaling may contribute to the down-regulation of miR-27b in acute leukemia cell lines through the ERK1/2 pathway, and that miR-27b may function as a tumor

  3. miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression

    SciTech Connect (OSTI)

    Yu, Peng; Wu, Dingguo; You, Yu; Sun, Jing; Lu, Lele; Tan, Jiaxing; Bie, Ping

    2015-08-15

    MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at post-transcriptional level. miRNA dysregulation plays a causal role in cancer progression. In this study, miR-208-3p was highly expressed and directly repressed ARID2 expression. As a result, ARID2 expression in hepatocellular carcinoma (HCC) was decreased. In vitro, miR-208-3p down-regulation and ARID2 over-expression elicited similar inhibitory effects on HCC cell proliferation and invasion. In vivo test results revealed that miR-208-3p down-regulation inhibited HCC tumorigenesis in Hep3B cells. Moreover, ARID2 was possibly a downstream element of transforming growth factor beta1 (TGFβ1)/miR-208-3p/ARID2 regulatory pathway. These findings suggested that miR-208-3p up-regulation is associated with HCC cell progression and may provide a new target for liver cancer treatment. - Highlights: • miR-208-3p was highly expressed and directly repressed the expression of ARID2 in HCC. • miR-208-3p contributed to HCC cell progression both in vitro and in vivo. • Over-expression of ARID2 inhibited the HCC cell proliferation and invasion. • Restoration of ARID2 partly reversed the the effect of miR-208-3p down-regulation on HCC cells. • Newly regulatory pathway: miR-208-3p mediated the repression of ARID2 by TGFβ1 in HCC cells.

  4. Curcumin inhibits oral squamous cell carcinoma SCC-9 cells proliferation by regulating miR-9 expression

    SciTech Connect (OSTI)

    Xiao, Can; Wang, Lili; Zhu, Lifang; Zhang, Chenping; Zhou, Jianhua

    2014-11-28

    Highlights: • miR-9 expression level was significantly decreased in OSCC tissues. • Curcumin significantly inhibited SCC-9 cells proliferation. • miR-9 mediates the inhibition of SCC-9 proliferation by curcumin. • Curcumin suppresses Wnt/β-catenin signaling in SCC-9 cells. • miR-9 mediates the suppression of Wnt/β-catenin signaling by curcumin. - Abstract: Curcumin, a phytochemical derived from the rhizome of Curcuma longa, has shown anticancer effects against a variety of tumors. In the present study, we investigated the effects of curcumin on the miR-9 expression in oral squamous cell carcinoma (OSCC) and explored the potential relationships between miR-9 and Wnt/β-catenin pathway in curcumin-mediated OSCC inhibition in vitro. As the results shown, the expression levels of miR-9 were significantly lower in clinical OSCC specimens than those in the adjacent non-tumor tissues. Furthermore, our results indicated that curcumin inhibited OSCC cells (SCC-9 cells) proliferation through up-regulating miR-9 expression, and suppressing Wnt/β-catenin signaling by increasing the expression levels of the GSK-3β, phosphorylated GSK-3β and β-catenin, and decreasing the cyclin D1 level. Additionally, the up-regulation of miR-9 by curcumin in SCC-9 cells was significantly inhibited by delivering anti-miR-9 but not control oligonucleotides. Downregulation of miR-9 by anti-miR-9 not only attenuated the growth-suppressive effects of curcumin on SCC-9 cells, but also re-activated Wnt/β-catenin signaling that was inhibited by curcumin. Therefore, our findings would provide a new insight into the use of curcumin against OSCC in future.

  5. miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway

    SciTech Connect (OSTI)

    Zhang, Yu; Wei, Guangkuan; Di, Zhiyong; Zhao, Qingjie

    2014-09-26

    Graphical abstract: - Highlights: • Alcohol upregulates miR-339-5p expression. • miR-339-5p inhibits the NF-kB pathway. • miR-339-5p interacts with and blocks activity of IKK-beat and IKK-epsilon. • miR-339-5p modulates IL-1β, IL-6 and TNF-α. - Abstract: Alcohol-induced neuroinflammation is mediated by the innate immunesystem. Pro-inflammatory responses to alcohol are modulated by miRNAs. The miRNA miR-339-5p has previously been found to be upregulated in alcohol-induced neuroinflammation. However, little has been elucidated on the regulatory functions of this miRNA in alcohol-induced neuroinflammation. We investigated the function of miR-339-5p in alcohol exposed brain tissue and isolated microglial cells using ex vivo and in vitro techniques. Our results show that alcohol induces transcription of miR 339-5p, IL-6, IL-1β and TNF-α in mouse brain tissue and isolated microglial cells by activating NF-κB. Alcohol activation of NF-κB allows for nuclear translocation of the NF-κB subunit p65 and expression of pro-inflammatory mediators. miR-339-5p inhibited expression of these pro-inflammatory factors through the NF-κB pathway by abolishing IKK-β and IKK-ε activity.

  6. Phase transition in bulk single crystals and thin films of <mi mathvariant='normal'>Vmi> mathvariant='normal'>Omi>2 by nanoscale infrared spectroscopy and imaging

    SciTech Connect (OSTI)

    Liu, Mengkun; Sternbach, Aaron J.; Wagner, Martin; Slusar, Tetiana V.; Kong, Tai; Bud'ko, Sergey L.; Kittiwatanakul, Salinporn; Qazilbash, M. M.; McLeod, Alexander; Fei, Zhe; Abreu, Elsa; Zhang, Jingdi; Goldflam, Michael; Dai, Siyuan; Ni, Guang -Xin; Lu, Jiwei; Bechtel, Hans A.; Martin, Michael C.; Raschke, Markus B.; Averitt, Richard D.; Wolf, Stuart A.; Kim, Hyun -Tak; Canfield, Paul C.; Basov, D. N.

    2015-06-29

    We have systematically studied a variety of vanadium dioxide (VO2) crystalline forms, including bulk single crystals and oriented thin films, using infrared (IR) near-field spectroscopic imaging techniques. By measuring the IR spectroscopic responses of electrons and phonons in VO2 with sub-grain-size spatial resolution (~20nm), we show that epitaxial strain in VO2 thin films not only triggers spontaneous local phase separations, but leads to intermediate electronic and lattice states that are intrinsically different from those found in bulk. Generalized rules of strain- and symmetry-dependent mesoscopic phase inhomogeneity are also discussed. Furthermore, these results set the stage for a comprehensive understanding of complex energy landscapes that may not be readily determined by macroscopic approaches.

  7. The SEMATECH Berkeley MET: extending EUV learning to 16-nm half pitch

    SciTech Connect (OSTI)

    Anderson, Christopher N.; Baclea-an, Lorie Mae; Denham, Paul E.; George, Simi; Goldberg, Kenneth A.; Jones, Michael; Smith, Nathan; Wallow, Thomas; Montgomery, Warren; Naulleau, Patrick P.

    2011-03-18

    Several high-performing resists identified in the past two years have been exposed at the 0.3-numerical-aperture (NA) SEMATECH Berkeley Microfield Exposure Tool (BMET) with an engineered dipole illumination optimized for 18-nm half pitch. Five chemically amplified platforms were found to support 20-nm dense patterning at a film thickness of approximately 45 nm. At 19-nm half pitch, however, scattered bridging kept all of these resists from cleanly resolving larger areas of dense features. At 18-nm half pitch, none of the resists were are able to cleanly resolve a single line within a bulk pattern. With this same illumination a directly imageable metal oxide hardmask showed excellent performance from 22-nm half pitch to 17-nm half pitch, and good performance at 16-nm half pitch, closely following the predicted aerial image contrast. This indicates that observed limitations of the chemically amplified resists are indeed coming from the resist and not from a shortcoming of the exposure tool. The imageable hardmask was also exposed using a Pseudo Phase-Shift-Mask technique and achieved clean printing of 15-nm half pitch lines and modulation all the way down to the theoretical 12.5-nm resolution limit of the 0.3-NA SEMATECH BMET.

  8. Post Mortem of 120k mi Light-Duty Urea SCR and DPF System | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Post Mortem of 120k mi Light-Duty Urea SCR and DPF System Post Mortem of 120k mi Light-Duty Urea SCR and DPF System Presentation given at the 2007 Diesel Engine-Efficiency & Emissions Research Conference (DEER 2007). 13-16 August, 2007, Detroit, Michigan. Sponsored by the U.S. Department of Energy's (DOE) Office of FreedomCAR and Vehicle Technologies (OFCVT). deer07_lambert.pdf (649.68 KB) More Documents & Publications Urea SCR and DPF System for Tier 2 Diesel Light-Duty

  9. Port Huron, MI Liquefied Natural Gas Exports to Canada (Million Cubic Feet)

    U.S. Energy Information Administration (EIA) Indexed Site

    to Canada (Million Cubic Feet) Port Huron, MI Liquefied Natural Gas Exports to Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2013 1 2014 1 1 1 1 2 1 1 1 1 1 2015 1 1 1 1 1 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 08/31/2016 Next Release Date: 09/30/2016 Referring Pages: U.S. Liquefied Natural Gas Exports by Point of Exit Port Huron, MI Natural Gas Exports to Canad

  10. MicroRNAs expression in ox-LDL treated HUVECs: MiR-365 modulates apoptosis and Bcl-2 expression

    SciTech Connect (OSTI)

    Qin, Bing; Xiao, Bo; Liang, Desheng; Xia, Jian; Li, Ye; Yang, Huan

    2011-06-24

    Highlights: {yields} We evaluated the role of miRNAs in ox-LDL induced apoptosis in ECs. {yields} We found 4 up-regulated and 11 down-regulated miRNAs in apoptotic ECs. {yields} Target genes of the dysregulated miRNAs regulate ECs apoptosis and atherosclerosis. {yields} MiR-365 promotes ECs apoptosis via suppressing Bcl-2 expression. {yields} MiR-365 inhibitor alleviates ECs apoptosis induced by ox-LDL. -- Abstract: Endothelial cells (ECs) apoptosis induced by oxidized low-density lipoprotein (ox-LDL) is thought to play a critical role in atherosclerosis. MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the expression of genes involved in diverse cell functions, including differentiation, growth, proliferation, and apoptosis. However, whether miRNAs are associated with ox-LDL induced apoptosis and their effect on ECs is still unknown. Therefore, this study evaluated potential miRNAs and their involvement in ECs apoptosis in response to ox-LDL stimulation. Microarray and qRT-PCR analysis performed on human umbilical vein endothelial cells (HUVECs) exposed to ox-LDL identified 15 differentially expressed (4 up- and 11 down-regulated) miRNAs. Web-based query tools were utilized to predict the target genes of the differentially expressed miRNAs, and the potential target genes were classified into different function categories with the gene ontology (GO) term and KEGG pathway annotation. In particular, bioinformatics analysis suggested that anti-apoptotic protein B-cell CLL/lymphoma 2 (Bcl-2) is a target gene of miR-365, an apoptomir up-regulated by ox-LDL stimulation in HUVECs. We further showed that transfection of miR-365 inhibitor partly restored Bcl-2 expression at both mRNA and protein levels, leading to a reduction of ox-LDL-mediated apoptosis in HUVECs. Taken together, our findings indicate that miRNAs participate in ox-LDL-mediated apoptosis in HUVECs. MiR-365 potentiates ox-LDL-induced ECs apoptosis by regulating the

  11. Scaling trends in SET pulse widths in Sub-100 nm bulk CMOS processes.

    SciTech Connect (OSTI)

    Narasimham, Balaji; Ahlbin, Jonathan R.; Schrimpf, Ronald D.; Gadlage, Matthew J.; Massengill, Lloyd W.; Vizkelethy, Gyorgy; Reed, Robert A.; Bhuva, Bharat L.

    2010-07-01

    Digital single-event transient (SET) measurements in a bulk 65-nm process are compared to transients measured in 130-nm and 90-nm processes. The measured SET widths are shorter in a 65-nm test circuit than SETs measured in similar 90-nm and 130-nm circuits, but, when the factors affecting the SET width measurements (in particular pulse broadening and the parasitic bipolar effect) are considered, the actual SET width trends are found to be more complex. The differences in the SET widths between test circuits can be attributed in part to differences in n-well contact area. These results help explain some of the inconsistencies in SET measurements presented by various researchers over the past few years.

  12. MiRNA-125a-5p inhibits glioblastoma cell proliferation and promotes cell differentiation by targeting TAZ

    SciTech Connect (OSTI)

    Yuan, Jian; Xiao, Gelei; Peng, Gang; Liu, Dingyang; Wang, Zeyou; Liao, Yiwei; Liu, Qing; Wu, Minghua; Yuan, Xianrui

    2015-02-06

    Highlights: • Expression of miR-125a-5p is inversely correlated with that of TAZ in glioma cells. • MiR-125a-5p represses TAZ expression in glioma cells. • MiR-125a-5p directly targets the 3′ UTR of TAZ mRNA and promotes its degradation. • MiR-125a-5p represses CTGF and survivin via TAZ, and inhibits glioma cell growth. • MiR-125a-5p inhibits the stem cell features of HFU-251 MG cells. - Abstract: Glioblastoma (GBM) is the most lethal brain tumor due to the resistance to conventional therapies, such as radiotherapy and chemotherapy. TAZ, an important mediator of the Hippo pathway, was found to be up-regulated in diverse cancers, including in GBM, and plays important roles in tumor initiation and progression. However, little is known about the regulation of TAZ expression in tumors. In this study, we found that miR-125a-5p is an important regulator of TAZ in glioma cells by directly targeting the TAZ 3′ UTR. MiR-125a-5p levels are inversely correlated with that of TAZ in normal astrocytes and a panel of glioma cell lines. MiR-125a-5p represses the expression of TAZ target genes, including CTGF and survivin, and inhibits cell proliferation and induces the differentiation of GBM cells; whereas over-expression of TAZ rescues the effects of miR-125a-5p. This study revealed a mechanism for TAZ deregulation in glioma cells, and also demonstrated a tumor suppressor role of miR-125a-5p in glioblastoma cells.

  13. QER Public Meeting in Santa Fe, NM: State, Local and Tribal Issues...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Office Auditorium 2600 Cerrillos Road Santa Fe, NM 87505-3258 Meeting Information Federal ... The entirety of all comments received in response to the Quadrennial Energy Review will ...

  14. Demonstration of 12 nm resolution Fresnel zone plate lens based soft x-ray microscopy

    SciTech Connect (OSTI)

    Chao, W.; Kim, J.; Rekawa, S.; Fischer, P.; Anderson, E. H.

    2009-06-05

    To extend soft x-ray microscopy to a resolution of order 10 nm or better, we developed a new nanofabrication process for Fresnel zone plate lenses. The new process, based on the double patterning technique, has enabled us to fabricate high quality gold zone plates with 12 nm outer zones. Testing of the zone plate with the full-field transmission x-ray microscope, XM-1, in Berkeley, showed that the lens clearly resolved 12 nm lines and spaces. This result represents a significant step towards 10 nm resolution and beyond.

  15. A widely tunable erbium-doped fiber laser pumped at 532 nm

    SciTech Connect (OSTI)

    Chen, C.Y. ); Choy, M.M.; Andrejco, M.J.; Saifi, M.A.; Lin, C. )

    1990-01-01

    In this paper, the authors report a tunable erbium-doped fiber laser with a very wide continuous-tuning range (1522--1567 nm). The wide tuning range was achieved using an aluminum/erbium-doped fiber; the aluminum co-doping is known to broaden the gain spectrum substantially. The tunable fiber laser has a ring laser configuration consisting of an in-line tunable etalon as the tuning element. Continuous tuning over 45 nm in the spectral range of 1522--1567 nm was achieved with 80 mW of pumping at 532 nm, using the second harmonic of a Nd:YAG laser as the pump source.

  16. The SEMATECH Berkeley MET pushing EUV development beyond 22-nm half pitch

    SciTech Connect (OSTI)

    Naulleau, P.; Anderson, C. N.; Backlea-an, L.-M.; Chan, D.; Denham, P.; George, S.; Goldberg, K. A.; Hoef, B.; Jones, G.; Koh, C.; La Fontaine, B.; McClinton, B.; Miyakawa, R.; Montgomery, W.; Rekawa, S.; Wallow, T.

    2010-03-18

    Microfield exposure tools (METs) play a crucial role in the development of extreme ultraviolet (EUV) resists and masks, One of these tools is the SEMATECH Berkeley 0.3 numerical aperture (NA) MET, Using conventional illumination this tool is limited to approximately 22-nm half pitch resolution. However, resolution enhancement techniques have been used to push the patterning capabilities of this tool to half pitches of 18 nm and below, This resolution was achieved in a new imageable hard mask which also supports contact printing down to 22 nm with conventional illumination. Along with resolution, line-edge roughness is another crucial hurdle facing EUV resists, Much of the resist LER, however, can be attributed to the mask. We have shown that intenssionally aggressive mask cleaning on an older generation mask causes correlated LER in photoresist to increase from 3.4 nm to 4,0 nm, We have also shown that new generation EUV masks (100 pm of substrate roughness) can achieve correlated LER values of 1.1 nm, a 3x improvement over the correlated LER of older generation EUV masks (230 pm of substrate roughness), Finally, a 0.5-NA MET has been proposed that will address the needs of EUV development at the 16-nm node and beyond, The tool will support an ultimate resolution of 8 nm half-pitch and generalized printing using conventional illumination down to 12 nm half pitch.

  17. EM, N.M. Officials Celebrate New Emergency Center for Waste Isolation...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    CARLSBAD, N.M. - Principal Deputy Assistant Secretary Mark Whitney joined New Mexico ... Recovery Manager Tammy Reynolds; New Mexico Environment Department Secretary Ryan ...

  18. DOE Zero Energy Ready Home Case Study: Cobblestone Homes, Midland, MI

    Broader source: Energy.gov [DOE]

    Case study of a DOE Zero Energy Ready home in Midland, MI, that scored HERS 49 without PV or HERS 44 with 1.4 kW of PV. The custom home served as a prototype and energy efficiency demonstration...

  19. The NuMI proton beam at Fermilab successes and challenges

    SciTech Connect (OSTI)

    Childress, S.; /Fermilab

    2008-11-01

    The NuMI beam at Fermilab has delivered over 5 x 10{sup 20} 120 GeV protons to the neutrino production target since the start for MINOS [1] neutrino oscillation experiment operation in 2005. We report on proton beam commissioning and operation status, including successes and challenges with this beam.

  20. MiR-18a regulates the proliferation, migration and invasion of human glioblastoma cell by targeting neogenin

    SciTech Connect (OSTI)

    Song, Yichen; Wang, Ping; Zhao, Wei; Yao, Yilong; Liu, Xiaobai; Ma, Jun; Xue, Yixue; Liu, Yunhui

    2014-05-15

    MiR-17-92 cluster has recently been reported as an oncogene in some tumors. However, the association of miR-18a, an important member of this cluster, with glioblastoma remains unknown. Therefore, this study aims to investigate the expression of miR-18a in glioblastoma and its role in biological behavior of U87 and U251 human glioblastoma cell lines. Quantitative RT-PCR results showed that miR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines compared with that in human brain tissues and primary normal human astrocytes, and the expression levels were increased along with the rising pathological grades of glioblastoma. Neogenin was identified as the target gene of miR-18a by dual-luciferase reporter assays. RT-PCR and western blot results showed that its expression levels were decreased along with the rising pathological grades of glioblastoma. Inhibition of miR-18a expression was established by transfecting exogenous miR-18a inhibitor into U87 and U251 cells, and its effects on the biological behavior of glioblastoma cells were studied using CCK-8 assay, transwell assay and flow cytometry. Inhibition of miR-18a expression in U87 and U251 cells significantly up-regulated neogenin, and dramatically suppressed the abilities of cell proliferation, migration and invasion, induced cell cycle arrest and promoted cellular apoptosis. Collectively, these results suggest that miR-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin, and miR-18a can serve as a potential target in the treatment of glioblastoma. - Highlights: • MiR-18a was highly expressed in glioblastoma tissues and U87 and U251 cell lines. • Neogenin was identified as the target gene of miR-18a. • Neogenin expressions were decreased along with the rising pathological grades of glioblastoma. • Inhibition of miR-18a suppressed biological behavior of glioma cells by up-regulating neogenin.

  1. miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer

    SciTech Connect (OSTI)

    Li, Qiaoyan; Zhu, Fufan; Chen, Puxiang

    2012-07-20

    Highlights: Black-Right-Pointing-Pointer Both miR-7 and miR-218 down-regulates HoxB3 expression by targeting the 3 Prime -UTR of HoxB3 mRNA. Black-Right-Pointing-Pointer A reverse correlation between the levels of endogenous miR-7, miR218 and HoxB3 expression. Black-Right-Pointing-Pointer Epigenetic changes involve in the reactivation of HoxB3. Black-Right-Pointing-Pointer Both miRNAs inhibits the cell cycle and clone formation of breast cancer cells. -- Abstract: Many microRNAs have been implicated as key regulators of cellular growth and differentiation and have been found to dysregulate proliferation in human tumors, including breast cancer. Cancer-linked microRNAs also alter the epigenetic landscape by way of DNA methylation and post-translational modifications of histones. Aberrations in Hox gene expression are important for oncogene or tumor suppressor during abnormal development and malignancy. Although recent studies suggest that HoxB3 is critical in breast cancer, the putative role(s) of microRNAs impinging on HoxB3 is not yet fully understood. In this study, we found that the expression levels of miR-7 and miR-218 were strongly and reversely associated with HoxB3 expression. Stable overexpression of miR-7 and miR-218 was accompanied by reactivation of tumor suppressor genes including RASSF1A and Claudin-6 by means of epigenetic switches in DNA methylation and histone modification, giving rise to inhibition of the cell cycle and clone formation of breast cancer cells. The current study provides a novel link between overexpression of collinear Hox genes and multiple microRNAs in human breast malignancy.

  2. Spectroscopic study of carbon plasma produced by the first (1064 nm) and second (532 nm) harmonics of Nd:YAG laser

    SciTech Connect (OSTI)

    Hanif, M.; Salik, M.; Arif, F.

    2015-03-15

    In this research work, spectroscopic studies of carbon (C) plasma by using laser-induced breakdown spectroscopy (LIBS) are presented. The plasma was produced by the first (1064 nm) and second (532 nm) harmonics of a Q-switched Nd:YAG (Quantel Brilliant) pulsed laser having a pulse duration of 5 ns and 10-Hz repetition rate, which is capable of delivering 400 mJ at 1064 nm and 200 mJ at 532 nm. The laser beam was focused on the target material (100% carbon) by placing it in air at atmospheric pressure. The experimentally observed line profiles of five neutral carbon (C I) lines at 247.85, 394.22, 396.14, 588.95, and 591.25 nm were used to extract the electron temperature T{sub e} by using the Boltzmann plot method and determine its value, 9880 and 9400 K, respectively, for the fundamental and second harmonics of the laser, whereas the electron density N{sub e} was determined from the Stark broadening profile of neutral carbon line at 247.85 nm. The values of N{sub e} at a distance of 0.05 mm from the target surface for the fundamental-harmonic laser with a pulse energy of 130 mJ and the second-harmonic laser with a pulse energy of 72 mJ are 4.68 × 10{sup 17} and 5.98 × 10{sup 17} cm{sup −3}, respectively. This extracted information on T{sub e} and N{sub e} is useful for the deposition of carbon thin films by using the pulsed laser deposition technique. Moreover, both plasma parameters (T{sub e} and N{sub e}) were also calculated by varying the distance from the target surface along the line of propagation of the plasma plume and also by varying the laser irradiance.

  3. Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation

    SciTech Connect (OSTI)

    Chen, Chao; Wu, Chao-Qun; Zhang, Zong-Qi; Yao, Ding-Kang; Zhu, Liang

    2011-07-15

    Activation and migration of resident stellate cells (HSCs) within the hepatic space of Disse play an important role in hepatic fibrosis, which accounts for the increased numbers of activated HSCs in areas of inflammation during hepatic fibrosis. Currently, microRNAs have been found to play essential roles in HSC differentiation, proliferation, apoptosis, fat accumulation and collagen production. However, little is known about microRNA mediated HSC activation and migration. In this study, the miRNA expression profiles of quiescent HSCs, partially activated HSCs and fully activated HSCs were compared in pairs. Gene ontology (GO) and GO-Map network analysis indicated that the activation of HSCs was regulated by microRNAs. Among them miR-335 was confirmed to be significantly reduced during HSC activation by qRT-PCR, and restoring expression of miR-335 inhibited HSC migration and reduced {alpha}-SMA and collagen type I. Previous study revealed that tenascin-C (TNC), an extracellular matrix glycoprotein involved in cell migration, might be a target of miR-335. Therefore, we further studied the TNC expression in miR-335 over-expressed HSCs. Our data showed that exogenous TNC could enhance HSC migration in vitro and miR-335 restoration resulted in a significant inhibition of TNC expression. These results demonstrated that miR-335 restoration inhibited HSC migration, at least in part, via downregulating the TNC expression.

  4. PSMB4 promotes multiple myeloma cell growth by activating NF-κB-miR-21 signaling

    SciTech Connect (OSTI)

    Zheng, Peihao; Guo, Honggang; Li, Guangchao; Han, Siqi; Luo, Fei; Liu, Yi

    2015-03-06

    Proteasomal subunit PSMB4, was recently identified as potential cancer driver genes in several tumors. However, the regulatory mechanism of PSMB4 on carcinogenesis process remains unclear. In this study, we investigated the expression and roles of PSMB4 in multiple myeloma (MM). We found a significant up-regulation of PSMB4 in MM plasma and cell lines. Ectopic overexpression of PSMB4 promoted cell growth and colony forming ability of MM cells, whereas inhibition of PSMB4 led to a decrease of such events. Furthermore, our results demonstrated the up-regulation of miR-21 and a positive correlation between the levels of miR-21 and PSMB4 in MM. Re-expression of miR-21 markedly rescued PSMB4 knockdown-mediated suppression of cell proliferation and clone-formation. Additionally, while enforced expression of PSMB4 profoundly increased NF-κB activity and the level of miR-21, PSMB4 knockdown or NF-κB inhibition suppressed miR-21 expression in MM cells. Taken together, our results demonstrated that PSMB4 regulated MM cell growth in part by activating NF-κB-miR-21 signaling, which may represent promising targets for novel specific therapies. - Highlights: • First reported upregulation of PSMB4 in MM plasma and cell lines. • PSMB4 promoted MM cell growth and colony forming ability. • Further found miR-21 was up-regulated by PSMB4 in MM plasma and cell lines. • PSMB4-induced miR-21 expression was modulated by NF-κB. • PSMB4-NF-κB-miR-21 axis may be potential therapeutic targets of MM.

  5. National Environmental Policy Act (NEPA) compliance at Sandia National Laboratories/New Mexico (SNL/NM)

    SciTech Connect (OSTI)

    Wolff, T.A.; Hansen, R.P.

    1998-08-01

    This report on National Environmental Policy Act (NEPA) compliance at Sandia National Laboratories/New Mexico (SNL/NM) chronicles past and current compliance activities and includes a recommended strategy that can be implemented for continued improvement. This report provides a list of important references. Attachment 1 contains the table of contents for SAND95-1648, National Environmental Policy Act (NEPA) Compliance Guide Sandia National Laboratories (Hansen, 1995). Attachment 2 contains a list of published environmental assessments (EAs) and environmental impact statements (EISs) prepared by SNL/NM. Attachment 3 contains abstracts of NEPA compliance papers authored by SNL/NM and its contractors.

  6. Aryl hydrocarbon receptor-dependent regulation of miR-196a expression controls lung fibroblast apoptosis but not proliferation

    SciTech Connect (OSTI)

    Hecht, Emelia; Zago, Michela; Sarill, Miles; Rico de Souza, Angela; Gomez, Alvin; Matthews, Jason; Hamid, Qutayba; Eidelman, David H.; Baglole, Carolyn J.

    2014-11-01

    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor implicated in the regulation of apoptosis and proliferation. Although activation of the AhR by xenobiotics such as dioxin inhibits the cell cycle and control apoptosis, paradoxically, AhR expression also promotes cell proliferation and survival independent of exogenous ligands. The microRNA (miRNA) miR-196a has also emerged as a regulator of proliferation and apoptosis but a relationship between the AhR and miR-196a is not known. Therefore, we hypothesized that AhR-dependent regulation of endogenous miR-196a expression would promote cell survival and proliferation. Utilizing lung fibroblasts from AhR deficient (AhR{sup −/−}) and wild-type (AhR{sup +/+}) mice, we show that there is ligand-independent regulation of miRNA, including low miR-196a in AhR{sup −/−} cells. Validation by qRT-PCR revealed a significant decrease in basal expression of miR-196a in AhR{sup −/−} compared to AhR{sup +/+} cells. Exposure to AhR agonists benzo[a]pyrene (B[a]P) and FICZ as well as AhR antagonist CH-223191 decreased miR-196a expression in AhR{sup +/+} fibroblasts concomitant with decreased AhR protein levels. There was increased proliferation only in AhR{sup +/+} lung fibroblasts in response to serum, corresponding to a decrease in p27{sup KIP1} protein, a cyclin-dependent kinase inhibitor. Increasing the cellular levels of miR-196a had no effect on proliferation or expression of p27{sup KIP1} in AhR{sup −/−} fibroblasts but attenuated cigarette smoke-induced apoptosis. This study provides the first evidence that AhR expression is essential for the physiological regulation of cellular miRNA levels- including miR-196a. Future experiments designed to elucidate the functional relationship between the AhR and miR-196a may delineate additional novel ligand-independent roles for the AhR. - Highlights: • The AhR controls proliferation and apoptosis in lung cells. • The AhR regulates the

  7. RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR...

    Office of Scientific and Technical Information (OSTI)

    in prostate cancer Citation Details In-Document Search Title: RLIP76-dependent suppression of PI3KAKTBcl-2 pathway by miR-101 induces apoptosis in prostate cancer MicroRNA-101 ...

  8. Material Activation Benchmark Experiments at the NuMI Hadron Absorber Hall in Fermilab

    SciTech Connect (OSTI)

    Matsumura, H.; Matsuda, N.; Kasugai, Y.; Toyoda, A.; Yashima, H.; Sekimoto, S.; Iwase, H.; Oishi, K.; Sakamoto, Y.; Nakashima, H.; Leveling, A.; Boehnlein, D.; Lauten, G.; Mokhov, N.; Vaziri, K.

    2014-06-15

    In our previous study, double and mirror symmetric activation peaks found for Al and Au arranged spatially on the back of the Hadron absorber of the NuMI beamline in Fermilab were considerably higher than those expected purely from muon-induced reactions. From material activation bench-mark experiments, we conclude that this activation is due to hadrons with energy greater than 3 GeV that had passed downstream through small gaps in the hadron absorber.

  9. Port Huron, MI Natural Gas Pipeline Imports From Canada (Million Cubic

    U.S. Energy Information Administration (EIA) Indexed Site

    Feet) Million Cubic Feet) Port Huron, MI Natural Gas Pipeline Imports From Canada (Million Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2016 262 278 16 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 08/31/2016 Next Release Date: 09/30/2016 Referring Pages: U.S.

  10. File:USDA-CE-Production-GIFmaps-NM.pdf | Open Energy Information

    Open Energy Info (EERE)

    NM.pdf Jump to: navigation, search File File history File usage New Mexico Ethanol Plant Locations Size of this preview: 776 600 pixels. Full resolution (1,650 1,275...

  11. HSQ double patterning process for 12 nm resolution x-ray zone...

    Office of Scientific and Technical Information (OSTI)

    algorithm, we have successfully fabricated in-house gold zone plates of 12 nm outer zones. ... Publication Date: 2009-06-16 OSTI Identifier: 963539 Report Number(s): LBNL-2100E TRN: ...

  12. NM Stat. 62-9 - The Utility Franchise | Open Energy Information

    Open Energy Info (EERE)

    NM Stat. 62-9 - The Utility FranchiseLegal Abstract This statute governs state law pertaining to utilities. Published NA Year Signed or Took Effect 2013 Legal Citation...

  13. Change LOS ALAMOS, N.M., May 19, 2015-Researchers at Los Alamos...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    tree mortality accelerating in forests May 19, 2015 Los Alamos' paper published in Nature Climate Change LOS ALAMOS, N.M., May 19, 2015-Researchers at Los Alamos National...

  14. DOI-BLM-NM-L000-2012-0020-DNA | Open Energy Information

    Open Energy Info (EERE)

    info. GDP from BLM's Grass Wells Database, LR2000 SRPs, or State Mineral Commissions Databases. Retrieved from "http:en.openei.orgwindex.php?titleDOI-BLM-NM-L000-2012-0020-DN...

  15. DOI-BLM-NM-L000-2012-0218-DNA | Open Energy Information

    Open Energy Info (EERE)

    info. GDP from BLM's Grass Wells Database, LR2000 SRPs, or State Mineral Commissions Databases. Retrieved from "http:en.openei.orgwindex.php?titleDOI-BLM-NM-L000-2012-0218-DN...

  16. Development of bottom-emitting 1300 nm vertical-cavity surface...

    Office of Scientific and Technical Information (OSTI)

    Title: Development of bottom-emitting 1300 nm vertical-cavity surface-emitting lasers. No abstract prepared. Authors: Fish, M. A. 1 ; Serkland, Darwin Keith ; Guilfoyle, Peter S. ...

  17. LOS ALAMOS, N.M., June 4, 2013-Los Alamos National Laboratory...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    laser-driven neutrons to stop nuclear smugglers June 4, 2013 Los Alamos shows first nuclear material detection by single short-pulse-laser-driven neutron source LOS ALAMOS, N.M., ...

  18. DOI-BLM-NM-L000-2012-0200-DNA | Open Energy Information

    Open Energy Info (EERE)

    00-DNA Jump to: navigation, search NEPA Document Collection for: DOI-BLM-NM-L000-2012-0200-DNA DNA at Lightning Dock Geothermal Area for GeothermalWell Field, DNA for Injection...

  19. DOI-BLM-NM-L000-2012-0111-DNA | Open Energy Information

    Open Energy Info (EERE)

    111-DNA Jump to: navigation, search NEPA Document Collection for: DOI-BLM-NM-L000-2012-0111-DNA DNA at Lightning Dock Geothermal Area for GeothermalExploration, DNA for Three...

  20. DOI-BLM-NM-L000-2012-0046-CX | Open Energy Information

    Open Energy Info (EERE)

    6-CX Jump to: navigation, search NEPA Document Collection for: DOI-BLM-NM-L000-2012-0046-CX CX at Lightning Dock Geothermal Area for GeothermalExploration CX at Lightning Dock...

  1. DOI-BLM-NM-L000-2012-0042-DNA | Open Energy Information

    Open Energy Info (EERE)

    2-DNA Jump to: navigation, search NEPA Document Collection for: DOI-BLM-NM-L000-2012-0042-DNA DNA at Lightning Dock Geothermal Area for GeothermalExploration DNA for Well 55-7 at...

  2. miR-21 modulates tumor outgrowth induced by human adipose tissue-derived mesenchymal stem cells in vivo

    SciTech Connect (OSTI)

    Shin, Keun Koo; Lee, Ae Lim; Kim, Jee Young; Medical Research Center for Ischemic Tissue Engineering, Pusan National University, Yangsan, Gyeongnam 626-870; BK21 Medical Science Education Center, School of Medicine, Pusan National University, Yangsan, Gyeongnam 626-870 ; Lee, Sun Young; Medical Research Center for Ischemic Tissue Engineering, Pusan National University, Yangsan, Gyeongnam 626-870 ; Bae, Yong Chan; Jung, Jin Sup

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer miR-21 modulates hADSC-induced increase of tumor growth. Black-Right-Pointing-Pointer The action is mostly mediated by the modulation of TGF-{beta} signaling. Black-Right-Pointing-Pointer Inhibition of miR-21 enhances the blood flow recovery in hindlimb ischemia. -- Abstract: Mesenchymal stem cells (MSCs) have generated a great deal of interest in clinical situations, due principally to their potential use in regenerative medicine and tissue engineering applications. However, the therapeutic application of MSCs remains limited, unless the favorable effects of MSCs on tumor growth in vivo, and the long-term safety of the clinical applications of MSCs, can be more thoroughly understood. In this study, we determined whether microRNAs can modulate MSC-induced tumor outgrowth in BALB/c nude mice. Overexpression of miR-21 in human adipose-derived stem cells (hADSCs) inhibited hADSC-induced tumor growth, and inhibition of miR-21 increased it. Downregulation of transforming growth factor beta receptor II (TGFBR2), but not of signal transducer and activator of transcription 3, in hADSCs showed effects similar to those of miR-21 overexpression. Downregulation of TGFBR2 and overexpression of miR21 decreased tumor vascularity. Inhibition of miR-21 and the addition of TGF-{beta} increased the levels of vascular endothelial growth factor and interleukin-6 in hADSCs. Transplantation of miR-21 inhibitor-transfected hADSCs increased blood flow recovery in a hind limb ischemia model of nude mice, compared with transplantation of control oligo-transfected cells. These findings indicate that MSCs might favor tumor growth in vivo. Thus, it is necessary to study the long-term safety of this technique before MSCs can be used as therapeutic tools in regenerative medicine and tissue engineering.

  3. Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro

    SciTech Connect (OSTI)

    Deng, Jun; Lei, Wan; Fu, Jian-Chun; Zhang, Ling; Li, Jun-He; Xiong, Jian-Ping

    2014-01-17

    Highlight: MiR-21 plays a significant role in 5-FU resistance. This role might be attributed to targeting of hMSH2 as well as TP and DPD via miR-21 targeted hMSH2. Indirectly targeted TP and DPD to influence 5-FU chemotherapy sensitivity. -- Abstract: 5-Fluorouracil (5-FU) is a classic chemotherapeutic drug that has been widely used for colorectal cancer treatment, but colorectal cancer cells are often resistant to primary or acquired 5-FU therapy. Several studies have shown that miR-21 is significantly elevated in colorectal cancer. This suggests that this miRNA might play a role in this resistance. In this study, we investigated this possibility and the possible mechanism underlying this role. We showed that forced expression of miR-21 significantly inhibited apoptosis, enhanced cell proliferation, invasion, and colony formation ability, promoted G1/S cell cycle transition and increased the resistance of tumor cells to 5-FU and X radiation in HT-29 colon cancer cells. Furthermore, knockdown of miR-21 reversed these effects on HT-29 cells and increased the sensitivity of HT-29/5-FU to 5-FU chemotherapy. Finally, we showed that miR-21 targeted the human mutS homolog2 (hMSH2), and indirectly regulated the expression of thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD). These results demonstrate that miR-21 may play an important role in the 5-FU resistance of colon cancer cells.

  4. Laser induced effects on ZnO targets upon ablation at 266 and 308 nm wavelengths

    SciTech Connect (OSTI)

    Jadraque, Maria; Martin, Margarita; Domingo, Concepcion

    2008-07-15

    The development of structural changes in ZnO targets, upon laser irradiation at the wavelengths of 266 and 308 nm, is studied by Raman spectroscopy. At the wavelength of 308 nm, oxygen vacancies are found to develop monotonically with increasing laser intensity. At 266 nm, a structural change in the irradiated ZnO targets, possibly related to nanostructuring, is observed above the laser fluence of 0.45 J cm{sup -2}. The different natures of the laser target interaction processes taking place at both wavelengths are investigated through the characterization of the composition and energy distribution of the species ejected in the ablation. The energy of the neutral Zn and Zn{sub 2} present in the ablation at 308 nm shows a smooth dependence on laser fluence which is consistent with the observed smooth development of oxygen vacancies. At 266 nm, the average kinetic energy of the ejected fragments is higher than at 308 nm and changes abruptly with the ablating laser fluence, consistently with the presence of a fluence threshold above which structural transform is observed at this wavelength. The plume shows the same neutral composition (Zn, ZnO, and Zn{sub 2}) at both wavelengths but the dependence on fluence of the ratio of neutral atomic Zn to the dimer Zn{sub 2} shows significant differences. From the latter, different temperature regimes can be inferred in the plume generated at both wavelengths. At 266 nm the cationic composition of the plume is mainly stoichiometric whereas at 308 nm ZnO{sub 2(3)}H{sub 2(1)}{sup +} cations have the highest intensity.

  5. DOE - Office of Legacy Management -- Ambrosia Lake Mill Site - NM 0-01

    Office of Legacy Management (LM)

    Ambrosia Lake Mill Site - NM 0-01 FUSRAP Considered Sites Site: Ambrosia Lake Mill Site (NM.0-01) Licensed to DOE for long-term custody and managed by the Office of Legacy Management Designated Name: Ambrosia Lake, New Mexico, Disposal Site Alternate Name: Ambrosia Lake Mill Site Uranium Mill in Ambrosia Lake Location: McKinley County, New Mexico Evaluation Year: Site Operations: Site Disposition: Uranium Mill Tailings Radiation Control Act (UMTRCA) Title I site Radioactive Materials Handled:

  6. DOE - Office of Legacy Management -- Blue Water AEC Ore Buying Station - NM

    Office of Legacy Management (LM)

    0-02 Blue Water AEC Ore Buying Station - NM 0-02 FUSRAP Considered Sites Site: Blue Water AEC Ore Buying Station (NM.0-02 ) Designated Name: Alternate Name: Location: Evaluation Year: Site Operations: Site Disposition: Radioactive Materials Handled: Primary Radioactive Materials Handled: Radiological Survey(s): Site Status: The history of domestic uranium procurement under U.S. Atomic Energy Commission (AEC) contracts identifies a number of ore buying stations (sampling and storage sites)

  7. DOE - Office of Legacy Management -- Grants AEC Ore Buying Station - NM 18

    Office of Legacy Management (LM)

    Grants AEC Ore Buying Station - NM 18 FUSRAP Considered Sites Site: Grants AEC Ore Buying Station (NM.18 ) Designated Name: Alternate Name: Location: Evaluation Year: Site Operations: Site Disposition: Radioactive Materials Handled: Primary Radioactive Materials Handled: Radiological Survey(s): Site Status: The history of domestic uranium procurement under U.S. Atomic Energy Commission (AEC) contracts identifies a number of ore buying stations (sampling and storage sites) that were operated

  8. DOE - Office of Legacy Management -- Project Gas Buggy Site - NM 14

    Office of Legacy Management (LM)

    Gas Buggy Site - NM 14 FUSRAP Considered Sites Site: Project Gas Buggy Site (NM.14 ) Designated Name: Alternate Name: Location: Evaluation Year: Site Operations: Site Disposition: Radioactive Materials Handled: Primary Radioactive Materials Handled: Radiological Survey(s): Site Status: Also see Gasbuggy, New Mexico, Site Nevada Test Site History Documents Related to Project Gas Buggy Site Fact Sheet Gasbuggy, New Mexico The Gasbuggy Site is located in northwestern New Mexico in Rio Arriba County

  9. DOE - Office of Legacy Management -- Shiprock Mill Site - NM 0-04

    Office of Legacy Management (LM)

    Shiprock Mill Site - NM 0-04 Site ID (CSD Index Number): NM.0-04 Site Name: Shiprock Mill Site Site Summary: Site Link: Shiprock Disposal, New Mexico, Site External Site Link: Alternate Name(s): Shiprock Mill Site Uranium Mill at Shiprock Alternate Name Documents: Location: Shiprock, New Mexico, Navajo Nation Location Documents: Historical Operations (describe contaminants): Historical Operations Documents: Eligibility Determination: Uranium Mill Tailings Radiation Control Act (UMTRCA) Title I

  10. Measurement of Pi-K Ratios from the NuMI Target

    SciTech Connect (OSTI)

    Seun, Sin Man; /Harvard U.

    2007-07-01

    Interactions of protons (p) with the NuMI (Neutrinos at the Main Injector) target are used to create the neutrino beam for the MINOS (Main Injector Neutrino Oscillation Search) Experiment. Using the MIPP (Main Injector Particle Production) experimental apparatus, the production of charged pions and kaons in p+NuMI interactions is studied. The data come from a sample of 2 x 10{sup 6} events obtained by MIPP using the 120 GeV/c proton beam from the Main Injector at Fermi National Accelerator Laboratory in Illinois, USA. Pions and kaons are identified by measurement in a Ring Imaging Cherenkov detector. Presented are measurements of {pi}{sup -}/{pi}{sup +}, K{sup -}/K{sup +}, {pi}{sup +}/K{sup +} and {pi}{sup -}/K{sup -} production ratios in the momentum range p{sub T} < 2 GeV/c transversely and 20 GeV/c < p{sub z} < 90 GeV/c longitudinally. Also provided are detailed comparisons of the MIPP NuMI data with the MIPP Thin Carbon data, the MIPP Monte Carlo simulation and the current MINOS models in the relevant momentum ranges.

  11. FINAL REPORT TESTS ON THE DURAMELTER 1200 HLW PILOT MELTER SYSTEM USING AZ-101 HLW SIMULANTS VSL-02R0100-2 REV 1 2/17/03

    SciTech Connect (OSTI)

    KRUGER AA; MATLACK KS; KOT WK; BARDAKCI T; GONG W; D'ANGELO NA; SCHATZ TR; PEGG IL

    2011-12-29

    This document provides the final report on data and results obtained from a series of nine tests performed on the one-third scale DuraMelter{trademark} 1200 (DM1200) HLW Pilot Melter system that has been installed at VSL with an integrated prototypical off-gas treatment system. That system has replaced the DM1000 system that was used for HLW throughput testing during Part B1 [1]. Both melters have similar melt surface areas (1.2 m{sup 2}) but the DM1200 is prototypical of the present RPP-WTP HLW melter design whereas the DM1000 was not. These tests were performed under a corresponding RPP-WTP Test Specification and associated Test Plans. The nine tests reported here were preceded by an initial series of short-duration tests conducted to support the start-up and commissioning of this system. This report is a followup to the previously issued Preliminary Data Summary Reports. The DM1200 system was deployed for testing and confirmation of basic design, operability, flow sheet, and process control assumptions as well as for support of waste form qualification and permitting. These tests include data on processing rates, off-gas treatment system performance, recycle stream compositions, as well as process operability and reliability. Consequently, this system is a key component of the overall HLW vitrification development strategy. The primary objective of the present series of tests was to determine the effects of a variety of parameters on the glass production rate in comparison to the RPP-WTP HL W design basis of 400 kg/m{sup 2}/d. Previous testing on the DMIOOO system [1] concluded that achievement of that rate with simulants of projected WTP melter feeds (AZ-101 and C-106/AY-102) was unlikely without the use of bubblers. As part of those tests, the same feed that was used during the cold-commissioning of the West Valley Demonstration Project (WVDP) HLW vitrification system was run on the DM1000 system. The DM1000 tests reproduced the rates that were obtained at the

  12. Imaging magnetic domain structure in sub-500 nm thin film elements

    SciTech Connect (OSTI)

    Kirk, K. J.; McVitie, S.; Chapman, J. N.; Wilkinson, C. D. W.

    2001-06-01

    Magnetic imaging in the transmission electron microscope (TEM) has been used to examine submicron elements with the aim of discovering down to what element size complex domain patterns can form. The elements were squares, circles, triangles, and pentagons in the size range 100{endash}500 nm and were made from 36 nm Co films or 8 nm Ni{sub 80}Fe{sub 20} (NiFe) with in-plane magnetization. The magnetic domain structures in these elements were imaged at high resolution using the differential phase contrast imaging mode in a TEM. Nonuniform magnetization structures were seen in the images. Vortices were present at remanence in all shapes of 36-nm-thick Co elements down to 100 nm size and in circular NiFe elements down to 116 nm diameter. Triangular NiFe elements did not have a vortex state at remanence, instead the magnetization curved round within the element but did not achieve complete flux closure. In simulations of square and circular NiFe elements, it was found that defects at the edges of the elements encouraged reversal by a vortex mechanism, whereas for simulated elements with no defects, reversal was by rotation and occurred at much lower fields. {copyright} 2001 American Institute of Physics.

  13. miR-502 inhibits cell proliferation and tumor growth in hepatocellular carcinoma through suppressing phosphoinositide 3-kinase catalytic subunit gamma

    SciTech Connect (OSTI)

    Chen, Suling; Li, Fang; Chai, Haiyun; Tao, Xin; Wang, Haili; Ji, Aifang

    2015-08-21

    MicroRNAs (miRNAs) play a key role in carcinogenesis and tumor progression in hepatocellular carcinoma (HCC). In the present study, we demonstrated that miR-502 significantly inhibits HCC cell proliferation in vitro and tumor growth in vivo. G1/S cell cycle arrest and apoptosis of HCC cells were induced by miR-502. Phosphoinositide 3-kinase catalytic subunit gamma (PIK3CG) was identified as a direct downstream target of miR-502 in HCC cells. Notably, overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells. Our findings suggest that miR-502 functions as a tumor suppressor in HCC via inhibition of PI3KCG, supporting its utility as a promising therapeutic gene target for this tumor type. - Highlights: • miR-502 suppresses HCC cell proliferation in vitro and tumorigenicity in vivo. • miR-502 regulates cell cycle and apoptosis in HCC cells. • PIK3CG is a direct target of miR-502. • miR-502 and PIK3CG expression patterns are inversely correlated in HCC tissues.

  14. MiR-145 is downregulated in human ovarian cancer and modulates cell growth and invasion by targeting p70S6K1 and MUC1

    SciTech Connect (OSTI)

    Wu, Huijuan; Xiao, ZhengHua; Wang, Ke; Liu, Wenxin; Hao, Quan

    2013-11-29

    Highlights: MiR-145 is downregulated in human ovarian cancer. MiR-145 targets p70S6K1 and MUC1. p70S6K1 and MUC1 are involved in miR-145 mediated tumor cell growth and cell invasion, respectively. -- Abstract: MicroRNAs (miRNAs) are a family of small non-coding RNA molecules that regulate gene expression at post-transcriptional levels. Previous studies have shown that miR-145 is downregulated in human ovarian cancer; however, the roles of miR-145 in ovarian cancer growth and invasion have not been fully demonstrated. In the present study, Northern blot and qRT-PCR analysis indicate that miR-145 is downregulated in ovarian cancer tissues and cell lines, as well as in serum samples of ovarian cancer, compared to healthy ovarian tissues, cell lines and serum samples. Functional studies suggest that miR-145 overexpression leads to the inhibition of colony formation, cell proliferation, cell growth viability and invasion, and the induction of cell apoptosis. In accordance with the effect of miR-145 on cell growth, miR-145 suppresses tumor growth in vivo. MiR-145 is found to negatively regulate P70S6K1 and MUC1 protein levels by directly targeting their 3?UTRs. Importantly, the overexpression of p70S6K1 and MUC1 can restore the cell colony formation and invasion abilities that are reduced by miR-145, respectively. MiR-145 expression is increased after 5-aza-CdR treatment, and 5-aza-CdR treatment results in the same phenotype as the effect of miR-145 overexpression. Our study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1, functioning as a tumor suppressor. Moreover, our data imply that miR-145 has potential as a miRNA-based therapeutic target for ovarian cancer.

  15. A compact ultranarrow high-power laser system for experiments with 578 nm ytterbium clock transition

    SciTech Connect (OSTI)

    Cappellini, G.; Lombardi, P.; Mancini, M.; Pagano, G.; Pizzocaro, M.; Fallani, L.; Catani, J.

    2015-07-15

    In this paper, we present the realization of a compact, high-power laser system able to excite the ytterbium clock transition at 578 nm. Starting from an external-cavity laser based on a quantum dot chip at 1156 nm with an intra-cavity electro-optic modulator, we were able to obtain up to 60 mW of visible light at 578 nm via frequency doubling. The laser is locked with a 500 kHz bandwidth to an ultra-low-expansion glass cavity stabilized at its zero coefficient of thermal expansion temperature through an original thermal insulation and correction system. This laser allowed the observation of the clock transition in fermionic {sup 173}Y b with a <50 Hz linewidth over 5 min, limited only by a residual frequency drift of some 0.1 Hz/s.

  16. Passivation of c-Si surfaces by sub-nm amorphous silicon capped with silicon nitride

    SciTech Connect (OSTI)

    Wan, Yimao Yan, Di; Bullock, James; Zhang, Xinyu; Cuevas, Andres

    2015-12-07

    A sub-nm hydrogenated amorphous silicon (a-Si:H) film capped with silicon nitride (SiN{sub x}) is shown to provide a high level passivation to crystalline silicon (c-Si) surfaces. When passivated by a 0.8 nm a-Si:H/75 nm SiN{sub x} stack, recombination current density J{sub 0} values of 9, 11, 47, and 87 fA/cm{sup 2} are obtained on 10 Ω·cm n-type, 0.8 Ω·cm p-type, 160 Ω/sq phosphorus-diffused, and 120 Ω/sq boron-diffused silicon surfaces, respectively. The J{sub 0} on n-type 10 Ω·cm wafers is further reduced to 2.5 ± 0.5 fA/cm{sup 2} when the a-Si:H film thickness exceeds 2.5 nm. The passivation by the sub-nm a-Si:H/SiN{sub x} stack is thermally stable at 400 °C in N{sub 2} for 60 min on all four c-Si surfaces. Capacitance–voltage measurements reveal a reduction in interface defect density and film charge density with an increase in a-Si:H thickness. The nearly transparent sub-nm a-Si:H/SiN{sub x} stack is thus demonstrated to be a promising surface passivation and antireflection coating suitable for all types of surfaces encountered in high efficiency c-Si solar cells.

  17. A 4 to 0.1 nm FEL Based on the SLAC Linac

    SciTech Connect (OSTI)

    Pellegrini, C.; /UCLA

    2012-06-05

    The author show that using existing electron gun technology and a high energy linac like the one at SLAC, it is possible to build a Free Electron Laser operating around the 4 nm water window. A modest improvement in the gun performance would further allow to extend the FEL to the 0.1 nm region. Such a system would produce radiation with a brightness many order of magnitude above that of any synchrotron radiation source, existing or under construction, with laser power in the multigawatt region and subpicosecond pulse length.

  18. Measurement of the quantum efficiency of TMAE and TEA from threshold to 120 nm

    SciTech Connect (OSTI)

    Holroyd, R.A.; Preses, J.M.; Woody, C.L.; Johnson, R.A.

    1986-01-01

    Several existing and planned high energy physics experiments incorporate detectors which use either TMAE (tetrakis-dimethylaminoethylene) or TEA (triethylamine) as their photosensitive agent. Understanding the operation of these devices requires knowledge of the absolute photoionization quantum efficiencies and absorption lengths of TMAE and TEA. In an experiment performed at the National Synchrotron Light source at Brookhaven National Laboratory, we have measured these parameters from 120 nm to 280 nm. The quantum efficiencies were normalized to the known photoionization yields of benzene and cis-2-butene. The results of these measurements and details of the experiment are presented in this paper.

  19. New Zone Plate for Soft X-Ray Microscopy at 15-nm Spatial Resolution

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    New Zone Plate for Soft X-Ray Microscopy at 15-nm Spatial Resolution New Zone Plate for Soft X-Ray Microscopy at 15-nm Spatial Resolution Print Wednesday, 31 August 2005 00:00 Analytical tools that combine spatial resolution with elemental and chemical identification at the nanometer scale along with large penetration depth are indispensable for the life and physical sciences. The XM-1 soft x-ray microscope at the ALS produces images that not only reveal structures but can identify their

  20. FINAL REPORT INTEGRATED DM1200 MELTER TESTING OF BUBBLER CONFIGURATIONS USING HLW AZ-101 SIMULANTS VSL-04R4800-4 REV 0 10/5/04

    SciTech Connect (OSTI)

    KRUGER AA; MATLACK KS; GONG W; BARDAKCI T; D'ANGELO NA; LUTZE W; CALLOW RA; BRANDYS M; KOT WK; PEGG IL

    2011-12-29

    This report documents melter and off-gas performance results obtained on the DM1200 HLW Pilot Melter during processing of AZ-101 HLW simulants. The tests reported herein are a subset of six tests from a larger series of tests described in the Test Plan for the work; results from the other tests have been reported separately. The solids contents of the melter feeds were based on the WTP baseline value for the solids content of the feeds from pretreatment which changed during these tests from 20% to 15% undissolved solids resulting in tests conducted at two feed solids contents. Based on the results of earlier tests with single outlet 'J' bubblers, initial tests were performed with a total bubbling rate of 651 pm. The first set of tests (Tests 1A-1E) addressed the effects of skewing this total air flow rate back and forth between the two installed bubblers in comparison to a fixed equal division of flow between them. The second set of tests (2A-2D) addressed the effects of bubbler depth. Subsequently, as the location, type and number of bubbling outlets were varied, the optimum bubbling rate for each was determined. A third (3A-3C) and fourth (8A-8C) set of tests evaluated the effects of alternative bubbler designs with two gas outlets per bubbler instead of one by placing four bubblers in positions simulating multiple-outlet bubblers. Data from the simulated multiple outlet bubblers were used to design bubblers with two outlets for an additional set of tests (9A-9C). Test 9 was also used to determine the effect of small sugar additions to the feed on ruthenium volatility. Another set of tests (10A-10D) evaluated the effects on production rate of spiking the feed with chloride and sulfate. Variables held constant to the extent possible included melt temperature, plenum temperature, cold cap coverage, the waste simulant composition, and the target glass composition. The feed rate was increased to the point that a constant, essentially complete, cold cap was achieved

  1. Testing CPT conservation using the NuMI neutrino beam with the MINOS experiment

    SciTech Connect (OSTI)

    Auty, David John

    2010-05-01

    The MINOS experiment was designed to measure neutrino oscillation parameters with muon neutrinos. It achieves this by measuring the neutrino energy spectrum and flavor composition of the man-made NuMI neutrino beam 1km after the beam is formed and again after 735 km. By comparing the two spectra it is possible to measure the oscillation parameters. The NuMI beam is made up of 7.0% {bar {nu}}{sub {mu}}, which can be separated from the {nu}{sub {mu}} because the MINOS detectors are magnetized. This makes it possible to study {bar {nu}}{sub {mu}} oscillations separately from those of muon neutrinos, and thereby test CPT invariance in the neutrino sector by determining the {bar {nu}}{sub {mu}} oscillation parameters and comparing them with those for {nu}{sub {mu}}, although any unknown physics of the antineutrino would appear as a difference in oscillation parameters. Such a test has not been performed with beam {bar {nu}}{sub {mu}} before. It is also possible to produce an almost pure {bar {nu}}{sub {mu}} beam by reversing the current through the magnetic focusing horns of the NuMI beamline, thereby focusing negatively, instead of positively charged particles. This thesis describes the analysis of the 7% {bar {nu}}{sub {mu}} component of the forward horn current NuMI beam. The {bar {nu}}{sub {mu}} of a data sample of 3.2 x 10{sup 20} protons on target analysis found 42 events, compared to a CPT conserving prediction of 58.3{sub -7.6}{sup +7.6}(stat.){sub -3.6}{sup +3.6}(syst.) events. This corresponds to a 1.9 {sigma} deficit, and a best fit value of {Delta}{bar m}{sub 32}{sup 2} = 18 x 10{sup -3} eV{sup 2} and sin{sup 2} 2{bar {theta}}{sub 23} = 0.55. This thesis focuses particularly on the selection of {bar {nu}}{sub {mu}} events, and investigates possible improvements of the selection algorithm. From this a different selector was chosen, which corroborated the findings of the original selector. The thesis also investigates how the systematic errors affect the

  2. DOE Zero Ready Home Case Study: Cobblestone Homes, 2014 Model Home, Midland, MI

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Cobblestone Homes 2014 Model Home Midland, MI DOE ZERO ENERGY READY HOME(tm) The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR Certified Homes Version 3.0 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies are designed

  3. Port Huron, MI Natural Gas Pipeline Imports From Canada (Dollars per

    U.S. Energy Information Administration (EIA) Indexed Site

    Thousand Cubic Feet) Dollars per Thousand Cubic Feet) Port Huron, MI Natural Gas Pipeline Imports From Canada (Dollars per Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2016 2.07 2.06 2.21 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 08/31/2016 Next Release Date: 09/30/2016 Referring Pages: U.S. Price of

  4. Efficient methylammonium lead iodide perovskite solar cells with active layers from 300 to 900 nm

    SciTech Connect (OSTI)

    Momblona, C.; Malinkiewicz, O.; Soriano, A.; Gil-Escrig, L.; Bandiello, E.; Scheepers, M.; Bolink, H. J.; Edri, E.

    2014-08-01

    Efficient methylammonium lead iodide perovskite-based solar cells have been prepared in which the perovskite layer is sandwiched in between two organic charge transporting layers that block holes and electrons, respectively. This configuration leads to stable and reproducible devices that do not suffer from strong hysteresis effects and when optimized lead to efficiencies close to 15%. The perovskite layer is formed by using a dual-source thermal evaporation method, whereas the organic layers are processed from solution. The dual-source thermal evaporation method leads to smooth films and allows for high precision thickness variations. Devices were prepared with perovskite layer thicknesses ranging from 160 to 900 nm. The short-circuit current observed for these devices increased with increasing perovskite layer thickness. The main parameter that decreases with increasing perovskite layer thickness is the fill factor and as a result optimum device performance is obtained for perovskite layer thickness around 300 nm. However, here we demonstrate that with a slightly oxidized electron blocking layer the fill factor for the solar cells with a perovskite layer thickness of 900 nm increases to the same values as for the devices with thin perovskite layers. As a result the power conversion efficiencies for the cells with 300 and 900 nm are very similar, 12.7% and 12%, respectively.

  5. Precursor to equatorial spread-F in OI 630.0 nm dayglow

    SciTech Connect (OSTI)

    Sridharan, R.; Raju, D.P.; Raghavarao, R.; Ramarao, P.V.S.

    1994-12-15

    The authors report a correlation between 630 nm O sdayglow measurements made from India and the occurance of equatorial spread F (ESF). They observe that features of the dayglow can serve as a precursor for the appearance of ESF phenomena, with a lead time of up to 3 hours.

  6. Performance of a High-Concentration Erbium-Doped Fiber Amplifier with 100 nm Amplification Bandwidth

    SciTech Connect (OSTI)

    Hajireza, P.; Shahabuddin, N. S.; Abbasi-Zargaleh, S.; Emami, S. D.; Abdul-Rashid, H. A.; Yusoff, Z.

    2010-07-07

    Increasing demand for higher bandwidth has driven the need for higher Wavelength Division Multiplexing (WDM) channels. One of the requirements to achieve this is a broadband amplifier. This paper reports the performance of a broadband, compact, high-concentration and silica-based erbium-doped fiber amplifier. The amplifier optimized to a 2.15 m long erbium-doped fiber with erbium ion concentration of 2000 ppm. The gain spectrum of the amplifier has a measured amplification bandwidth of 100 nm using a 980 nm laser diode with power of 150 mW. This silica-based EDFA shows lower noise figure, higher gain and wider bandwidth in shorter wavelengths compared to Bismuth-based EDFA with higher erbium ion concentration of 3250 ppm at equivalent EDF length. The silica-based EDF shows peak gain at 22 dB and amplification bandwidth between 1520 nm and 1620 nm. The lowest noise figure is 5 dB. The gain is further improved with the implementation of enhanced EDFA configurations.

  7. Imaging of electrical response of NiOx under controlled environment with sub-25-nm resolution

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Jacobs, Christopher B.; Ievlev, Anton V.; Collins, Liam F.; Muckley, Eric S.; Joshi, Pooran C.; Ivanov, Ilia N.

    2016-07-19

    The spatially resolved electrical response of rf-sputtered polycrystalline NiOx films composed of 40 nm crystallites was investigated under different relative humidity levels (RH). The topological and electrical properties (surface potential and resistance) were characterized using Kelvin probe force microscopy (KPFM) and conductive scanning probe microscopy at 0%, 50%, and 80% relative humidity with sub 25nm resolution. The surface potential of NiOx decreased by about 180 mV and resistance decreased in a nonlinear fashion by about 2 G when relative humidity was increased from 0% to 80%. The dimensionality of surface features obtained through autocorrelation analysis of topological, surface potential andmore » resistance maps increased linearly with increased relative humidity as water was adsorbed onto the film surface. Spatially resolved surface potential and resistance of the NiOx films were found to be heterogeneous, with distinct features that grew in size from about 60 nm to 175 nm between 0% and 80% RH levels, respectively. Here, we find that the changes in the heterogeneous character of the NiO films are consistent through the topological, surface potential, and resistance measurements, suggesting that the nanoscale surface potential and resistance properties converge with the mesoscale properties as water is adsorbed onto the NiOx film.« less

  8. EM, N.M. Officials Celebrate New Emergency Center for Waste Isolation Pilot Plant

    Broader source: Energy.gov [DOE]

    CARLSBAD, N.M. – Principal Deputy Assistant Secretary Mark Whitney joined New Mexico officials and others to mark the completion of a new state-of-the-art Waste Isolation Pilot Plant (WIPP) Emergency Operations Center in a ribbon-cutting ceremony recently.

  9. miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6, cyclin-D1 and cyclin-D2

    SciTech Connect (OSTI)

    Li, Xuesong; Gong, Xuhai; Chen, Jing; Zhang, Jinghui; Sun, Jiahang; Guo, Mian

    2015-05-08

    Glioblastoma development is often associated with alteration in the activity and expression of cell cycle regulators, such as cyclin-dependent kinases (CKDs) and cyclins, resulting in aberrant cell proliferation. Recent studies have highlighted the pivotal roles of miRNAs in controlling the development and growth of glioblastoma. Here, we provide evidence for a function of miR-340 in the inhibition of glioblastoma cell proliferation. We found that miR-340 is downregulated in human glioblastoma tissue samples and several established glioblastoma cell lines. Proliferation and neurosphere formation assays revealed that miR-340 plays an oncosuppressive role in glioblastoma, and that its ectopic expression causes significant defect in glioblastoma cell growth. Further, using bioinformatics, luciferase assay and western blot, we found that miR-340 specifically targets the 3′UTRs of CDK6, cyclin-D1 and cyclin-D2, leading to the arrest of glioblastoma cells in the G0/G1 cell cycle phase. Confirming these results, we found that re-introducing CDK6, cyclin-D1 or cyclin-D2 expression partially, but significantly, rescues cells from the suppression of cell proliferation and cell cycle arrest mediated by miR-340. Collectively, our results demonstrate that miR-340 plays a tumor-suppressive role in glioblastoma and may be useful as a diagnostic biomarker and/or a therapeutic avenue for glioblastoma. - Highlights: • miR-340 is downregulated in glioblastoma samples and cell lines. • miR-340 inhibits glioblastoma cell proliferation. • miR-340 directly targets CDK6, cyclin-D1, and cyclin-D2. • miR-340 regulates glioblastoma cell proliferation via CDK6, cyclin-D1 and cyclin-D2.

  10. Assessment of radiological releases from the NuMI facility during MINOS and NOvA operations

    SciTech Connect (OSTI)

    Martens, Mike; /Fermilab

    2007-04-01

    This report makes projections of the radiological releases from the NuMI facility during operations for the MINOS and NO ?A experiments. It includes an estimate of the radionuclide levels released into the atmosphere and the estimated tritium and sodium-22 concentrations in the NuMI sump water and Fermilab pond system. The analysis was performed for NuMI operations with a beam power on target increased from the present 400 kW design up to a possible 1500 kW with future upgrades. The total number of protons on target was assumed to be 18 x 10{sup 20} after the completion of MINOS and 78 x 10{sup 20} after the completion of NO ?A.

  11. THE INFRARED SPECTRUM OF URANIUM HOLLOW CATHODE LAMPS FROM 850 nm to 4000 nm: WAVENUMBERS AND LINE IDENTIFICATIONS FROM FOURIER TRANSFORM SPECTRA

    SciTech Connect (OSTI)

    Redman, Stephen L.; Ramsey, Lawrence W.; Mahadevan, Suvrath [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States); Lawler, James E. [Department of Physics, University of Wisconsin, 1150 University Avenue, Madison, WI 53706 (United States); Nave, Gillian [National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States)

    2011-08-01

    We provide new measurements of wavenumbers and line identifications of 10, 100 U I and U II near-infrared (NIR) emission lines between 2500 cm{sup -1} and 12, 000 cm{sup -1} (4000-850 nm) using archival Fourier transform spectrometer spectra from the National Solar Observatory. This line list includes isolated uranium lines in the Y, J, H, K, and L bands (0.9-1.1 {mu}m, 1.2-1.35 {mu}m, 1.5-1.65 {mu}m, 2.0-2.4 {mu}m, and 3.0-4.0 {mu}m, respectively), and provides six times as many calibration lines as thorium in the NIR spectral range. The line lists we provide enable inexpensive, commercially available uranium hollow cathode lamps to be used for high-precision wavelength calibration of existing and future high-resolution NIR spectrographs.

  12. MAGNETIC FIELDS OF AN ACTIVE REGION FILAMENT FROM FULL STOKES ANALYSIS OF Si I 1082.7 nm AND He I 1083.0 nm

    SciTech Connect (OSTI)

    Xu, Z.; Liu, Y.

    2012-04-20

    Vector magnetic fields of an active region filament in the photosphere and upper chromosphere are obtained from spectro-polarimetric observations recorded with the Tenerife Infrared Polarimeter (TIP II) at the German Vacuum Tower Telescope. We apply Milne-Eddington inversions on full Stokes vectors of the photospheric Si I 1082.7 nm and the upper chromospheric He I triplet at 1083.0 nm to obtain the magnetic field vector and velocity maps in two atmosphere layers. We find that (1) a complete filament was already present in H{alpha} at the beginning of the TIP II data acquisition. Only a partially formed one, composed of multiple small threads, was present in He I. (2) The AR filament comprises two sections. One shows strong magnetic field intensities, about 600-800 G in the upper chromosphere and 800-1000 G in the photosphere. The other exhibits only comparatively weak magnetic field strengths in both layers. (3) The Stokes V signal is indicative of a dip in the magnetic field strength close to the chromospheric PIL. (4) In the chromosphere, consistent upflows are found along the PIL flanked by downflows. (5) The transversal magnetic field is nearly parallel to the PIL in the photosphere and inclined by 20 Degree-Sign -30 Degree-Sign in the chromosphere. (6) The chromospheric magnetic field around the filament is found to be in normal configuration, while the photospheric field presents a concave magnetic topology. The observations are consistent with the emergence of a flux rope with a subsequent formation of a filament.

  13. Intrinsic Bioprobes, Inc. (Tempe, AZ)

    DOE Patents [OSTI]

    Nelson, Randall W.; Williams, Peter; Krone, Jennifer Reeve

    2008-07-15

    Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration.

  14. MiR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1

    SciTech Connect (OSTI)

    Xu, Juan; Li, Li; Yun, Hui-fang; Han, Ye-shan

    2015-08-07

    Background: Diabetic vascular smooth muscle cells (VSMCs) exhibit significantly increased rates of proliferation and migration, which was the most common pathological change in atherosclerosis. In addition, the study about the role for miRNAs in the regulation of VSMC proliferation is just beginning to emerge and additional miRNAs involved in VSMC proliferation modulation should be identified. Methods: The expression of miR-138 and SIRT1 were examined in SMCs separated from db/db mice and in SMC lines C-12511 exposed to high glucose with qRT-PCR and western blot. The regulation of miR-138 on the expression of SMCs was detected with luciferase report assay. VSMCs proliferation and migration assays were performed to examine the effect of miR-138 inhibitor on VSMCs proliferation and migration. Results: We discovered that higher mRNA level of miR-138 and reduced expression of SIRT1 were observed in SMCs separated from db/db mice and in SMC lines C-12511. Moreover, luciferase report assay showed that the activity of SIRT1 3′-UTR was highly increased by miR-138 inhibitor and reduced by miR-138 mimic. In addition, we examined that the up-regulation of NF-κB induced by high glucose in SMCs was reversed by resveratrol and miR-138 inhibitor. MTT and migration assays showed that miR-138 inhibitor attenuated the proliferation and migration of smooth muscle cells. Conclusion: In this study, we revealed that miR-138 might promote proliferation and migration of SMC in db/db mice through suppressing the expression of SIRT1. - Highlights: • Higher mRNA level of miR-138 was observed in SMCs from db/db mice. • The mRNA and protein level of SIRT1 in SMCs from db/db mice were greatly reduced. • miR-138 could regulate the expression of SIRT1 in SMCs. • SIRT1 overexpression reversed the up-regulation of acetylized p65 and NF-κB induced by high glucose. • MiR-138 inhibitor reversed VSMCs proliferation and migration induced by high glucose.

  15. miR-206 is down-regulated in breast cancer and inhibits cell proliferation through the up-regulation of cyclinD2

    SciTech Connect (OSTI)

    Zhou, Jing; Tian, Ye; Li, Juan; Lu, Binbin; Sun, Ming; Zou, Yanfen; Kong, Rong; Luo, Yanhong; Shi, Yongguo; Wang, Keming; Ji, Guozhong

    2013-04-05

    Highlights: ? miR-206 was downexpressed in tumor samples compared with matched normal samples. ? Enhanced expression of miR-206 could inhibit breast cancer growth in vitro. ? Luciferase confirmed miR-206 functions as an anti-oncogene by targeting cyclinD2. ? A reverse correlation between miR-206 and cyclinD2 in breast cancer was found. -- Abstract: MicroRNAs act as important gene regulators in human genomes, and their aberrant expression is linked to many malignancies. Aberrant expression of miR-206 has been frequently reported in cancer studies; however, the role and mechanism of its function in breast cancer remains unclear. Quantitative real-time PCR was performed to detect the relative expression levels of miR-206 in breast cancer and normal breast tissues. Lower expression of miR-206 in breast cancer tissues was associated with larger tumour size and a more advanced clinical stage. Further in vitro observations showed that the enforced expression of miR-206 in MCF-7 breast cancer cells inhibited cell growth by blocking the G1/S transition and suppressed cell proliferation and colony formation, implying that miR-206 functions as a tumour suppressor in the progression of breast cancer. Interestingly, Luciferase assays first revealed that miR-206 inhibited cyclinD2 expression by targeting two binding sites in the 3?-untranslated region of cyclinD2 mRNA. qRT-PCR and Western blot assays verified that miR-206 reduced cyclinD2 expression at both the mRNA and protein levels. A reverse correlation between miR-206 and cyclinD2 expression was noted in breast cancer tissues. Altogether, our results identify a crucial tumour suppressive role of miR-206 in the progression of breast cancer, at least partly via up-regulation of the expression of cyclinD2, and suggest that miR-206 might be a candidate prognostic predictor or an anticancer therapeutic target for breast cancer patients.

  16. Stable formation of ultrahigh power-density 248 nm channels in Xe cluster targets

    SciTech Connect (OSTI)

    Borisov, Alex B.; Racz, Ervin; Khan, Shahab F.; Poopalasingam, Sankar; McCorkindale, John C.; Boguta, John; Longworth, James W.; Rhodes, Charles K.

    2012-07-11

    The optimization of relativistic and ponderomotive self-channeling of ultra-powerful 248 nm laser pulses launched in underdense plasmas with an appropriate longitudinal gradient in the electron density profile located at the initial stage of the self-channeling leads to (1) stable channel formation and (2) highly efficient power compression producing power densities in the 10{sup 19}-10{sup 20} W/cm{sup 3} range. The comparison of theoretical studies with experimental results involving the correlation of (a) Thomson images of the electron density with (b) x-ray images of the channel morphology demonstrates that more than 90% of the incident 248 nm power can be trapped in stable channels and that this stable propagation can be extended to power levels significantly exceeding the critical power of the self-channeling process.

  17. 32.8-nm X-ray laser produced in a krypton cluster jet

    SciTech Connect (OSTI)

    Ivanova, E P; Vinokhodov, A Yu

    2013-12-31

    We have interpreted the well-known experimental quantum yield data for a 32.8-nm X-ray laser operating at the 3d{sup 9}4d (J = 0) 3d{sup 9}4p (J = 1) transition of Kr{sup 8+} with the use of gaseous krypton or a krypton cluster jet. Proceeding from our model we propose a novel scheme for the 32.8-nm laser produced in a krypton cluster jet. The quantum yield is shown to saturate for a plasma length of ?300 ?m, a krypton ion density n{sub Kr} ? (4 9) 10{sup 19} cm{sup -3}, and an electron temperature Te ? 5000 eV. In this case, the energy conversion coefficient amounts to ?5 10{sup -3} of the pump pulse energy. We propose the experimental setup for producing a highefficiency subpicosecond X-ray laser in a krypton cluster jet. (lasers)

  18. Demonstration of a GaAs-based 1550-nm continuous wave photomixer

    SciTech Connect (OSTI)

    Zhang, W.-D. Brown, E. R.; Middendorf, J. R.

    2015-01-12

    An Er:GaAs-based 1550-nm CW photomixer is demonstrated. The related mechanism is extrinsic photoconductivity with optical absorption between the localized deep levels created by the Er and the extended states above the conduction band edge of GaAs. With the power boost made possible by a fiber-coupled erbium-doped-fiber amplifier, the Er:GaAs photomixers, operating at 1550 nm, radiate THz power levels easily measured by a Golay cell, and display a power spectrum having a −3 dB roll-off frequency of 307 GHz. This corresponds to a photocarrier lifetime of 520 fs, in good agreement with a previous measurement of the bandwidth of the same material in a photoconductive switch.

  19. A InGaN/GaN quantum dot green ({lambda}=524 nm) laser

    SciTech Connect (OSTI)

    Zhang Meng; Banerjee, Animesh; Lee, Chi-Sen; Hinckley, John M.; Bhattacharya, Pallab

    2011-05-30

    The characteristics of self-organized InGaN/GaN quantum dot lasers are reported. The laser heterostructures were grown on c-plane GaN substrates by plasma-assisted molecular beam epitaxy and the laser facets were formed by focused ion beam etching with gallium. Emission above threshold is characterized by a peak at 524 nm (green) and linewidth of 0.7 nm. The lowest measured threshold current density is 1.2 kA/cm{sup 2} at 278 K. The slope and wall plug efficiencies are 0.74 W/A and {approx}1.1%, respectively, at 1.3 kA/cm{sup 2}. The value of T{sub 0}=233 K in the temperature range of 260-300 K.

  20. Museum LOS ALAMOS, N.M., Sept. 5, 2013-Los Alamos National Laboratory Director Charlie

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    lab director to link science education, national security in TEDxABQ talk September 5, 2013 Watch live stream at home or at Bradbury Science Museum LOS ALAMOS, N.M., Sept. 5, 2013-Los Alamos National Laboratory Director Charlie McMillan will discuss the linkage between national security and early education in science, technology, engineering, and mathematics (STEM) during a presentation at the TEDxABQ conference in Albuquerque on Saturday, Sept. 7. Although the event is expected to sell out

  1. New Zone Plate for Soft X-Ray Microscopy at 15-nm Spatial Resolution

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    New Zone Plate for Soft X-Ray Microscopy at 15-nm Spatial Resolution Print Analytical tools that combine spatial resolution with elemental and chemical identification at the nanometer scale along with large penetration depth are indispensable for the life and physical sciences. The XM-1 soft x-ray microscope at the ALS produces images that not only reveal structures but can identify their chemical elements and measure magnetic and other properties as well. Now a new method for creating optical

  2. Michaela G. Farr and Joshua S. Stein Sandia National Laboratory, Albuquerque, NM, 87185, United States

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Spatial Variations in Temperature across a Photovoltaic Array Michaela G. Farr and Joshua S. Stein Sandia National Laboratory, Albuquerque, NM, 87185, United States ABSTRACT - The efficiency of any photovoltaic device is significantly affected by its operating temperature. It is therefore of great interest to the PV industry to have accurate models of module and array temperatures. Existing PV performance models generally assume that module temperature is a function of plane-of-array irradiance,

  3. LOS ALAMOS, N.M., April 2, 2015-Randy Fraser of Los Alamos National Laboratory's

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Randy Fraser receives NNSA 2014 Security Professional of the Year award April 2, 2015 LOS ALAMOS, N.M., April 2, 2015-Randy Fraser of Los Alamos National Laboratory's Security, Safeguards and Emergency Response Directorate received a 2014 National Nuclear Security Administration Security Professional of the Year award. "I am extremely honored to have the privilege of presenting these amazing individuals with the Bradley A. Peterson Federal and Contractor Security Professional of the Year

  4. LOS ALAMOS, N.M., April 7, 2016-Los Alamos and Sandia National Laboratories

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Looking inside plutonium April 7, 2016 New Mexico labs go where no one has gone before LOS ALAMOS, N.M., April 7, 2016-Los Alamos and Sandia National Laboratories have recently conducted plutonium experiments using Sandia's pulsed power Z Machine that have reached regions of pressure, temperature and density in plutonium never before explored in the laboratory. "With Z we have very carefully reached pressure, temperature and density regimes that are relevant to those seen during a nuclear

  5. LOS ALAMOS, N.M., Aug. 24, 2016-Eight Los Alamos National Laboratory innovations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    as R&D 100 Award finalists August 24, 2016 Eight technologies offer breakthroughs in energy, computing, cybersecurity, health, materials and particle accelerators LOS ALAMOS, N.M., Aug. 24, 2016-Eight Los Alamos National Laboratory innovations were selected as finalists for the 2016 R&D 100 Awards, which honor the top 100 proven technological advances of the past year as determined by a panel selected by R&D Magazine. The finalists, with projects covering energy, computing, health

  6. LOS ALAMOS, N.M., Dec. 15, 2014-The Los Alamos National Laboratory Fellows list

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Laboratory Fellows for 2014 December 15, 2014 Honorees span sciences in physics, astrophysics, chemistry LOS ALAMOS, N.M., Dec. 15, 2014-The Los Alamos National Laboratory Fellows list expands by five this week as a new group of high achievers is named. The honorees this year are Christopher L. Fryer, Herbert O. Funsten, John C. Gordon, Jaqueline L. Kiplinger and David S. Moore. "The sustained scientific excellence demonstrated by the work of Chris, Herb, John, Jaqueline and David

  7. LOS ALAMOS, N.M., Dec. 17, 2015-Scientists at Los Alamos National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    more accurately tracks gases for underground nuclear explosion detection December 17, 2015 Model uniquely pairs seismic data with radionuclide fluid-flow models LOS ALAMOS, N.M., Dec. 17, 2015-Scientists at Los Alamos National Laboratory have developed a new, more thorough method for detecting underground nuclear explosions (UNEs) by coupling two fundamental elements-seismic models with gas-flow models-to create a more complete picture of how an explosion's evidence (radionuclide gases) seep to

  8. LOS ALAMOS, N.M., Dec. 22, 2014-Los Alamos National Laboratory today

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    science news of 2014 December 22, 2014 Biosurveillance, secure computing, alternative energy, unique capabilities highlight the year LOS ALAMOS, N.M., Dec. 22, 2014-Los Alamos National Laboratory today announced its annual top science stories of 2014. The 12 stories selected from diverse disciplines supporting Los Alamos's national security mission range from transferring fool-proof computer encryption techniques to market, to using social media for forecasting diseases, creating a virtual human

  9. LOS ALAMOS, N.M., Dec. 3, 2015-Los Alamos National Laboratory molecular

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    explore new strategies to improve photosynthesis, increase energy yields December 6, 2015 First talk is Monday, Dec. 7 in Albuquerque LOS ALAMOS, N.M., Dec. 3, 2015-Los Alamos National Laboratory molecular biologist Richard Sayre discusses how improving photosynthetic efficiency may result in substantial increases in crop yields during two Frontiers in Science lectures titled "Hacking Photosynthesis: Growing Plants to Power Our Engines and Feed the World" beginning Dec. 7 in

  10. LOS ALAMOS, N.M., Feb. 23, 2015-Nine Los Alamos National Laboratory scientists

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    join prestigious ranks of APS fellows February 23, 2015 LOS ALAMOS, N.M., Feb. 23, 2015-Nine Los Alamos National Laboratory scientists are new Fellows of the American Physical Society. Cristian Batista, Malcolm Boshier, Dana Dattelbaum, Stephen Doorn, Michelle Espy, George Rodriguez, Avadh Saxena, Sergei Tretiak and Lin Yin are the new honorees. "Selection as American Physical Society fellows is de facto proof of the vibrant engagement Los Alamos scientists are having with the larger

  11. LOS ALAMOS, N.M., July 1, 2014-Los Alamos National Laboratory employees

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    27,000 pledged by Los Alamos National Laboratory employees in 2014 LAESF scholarship drive July 1, 2014 Investing in success of Northern New Mexico students LOS ALAMOS, N.M., July 1, 2014-Los Alamos National Laboratory employees pledged a record $327,000 during the recently completed 2014 Los Alamos Employees' Scholarship Fund (LAESF) drive. The drive encourages Laboratory employees, retirees, and subcontract personnel to donate to a fund that awards college scholarships to Northern New Mexico

  12. LOS ALAMOS, N.M., July 24, 2014-Dipen Sinha of Los Alamos National Laboratory's

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Acoustics topic of upcoming Frontiers in Science series July 24, 2014 Tapping sound waves to address energy, national security challenges LOS ALAMOS, N.M., July 24, 2014-Dipen Sinha of Los Alamos National Laboratory's Materials Synthesis and Integrated Devices group will discuss acoustics and its applications, including how it is possible to use sound to solve problems in health, national security and for industry, in a series of Frontiers in Science Lectures beginning July 29 at Crossroads

  13. LOS ALAMOS, N.M., June 18, 2014-Los Alamos National Laboratory today

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fukushima with cosmic rays should speed cleanup June 18, 2014 Los Alamos to partner with Toshiba to remotely and safely peer inside nuclear reactors LOS ALAMOS, N.M., June 18, 2014-Los Alamos National Laboratory today announced an impending partnership with Toshiba Corporation to use a Los Alamos technique called muon tomography to safely peer inside the cores of the Fukushima Daiichi reactors and create high-resolution images of the damaged nuclear material inside without ever breaching the

  14. LOS ALAMOS, N.M., June 21, 2016-Two Los Alamos National Laboratory projects

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    energy technology projects from Los Alamos gain DOE funding June 21, 2016 Groundwater restoration and fractured rock insights supported LOS ALAMOS, N.M., June 21, 2016-Two Los Alamos National Laboratory projects are among technologies supported in today's U.S. Department of Energy (DOE) announcement of nearly $16 million in funding to help businesses move promising energy technologies from DOE's National Laboratories to the marketplace. "Los Alamos research expands the options for energy

  15. LOS ALAMOS, N.M., June 24, 2015-Scientists at Los Alamos National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ocean mixing reveals insight on climate June 24, 2015 Eddies pull carbon emissions into deep ocean, new model simulates complex process LOS ALAMOS, N.M., June 24, 2015-Scientists at Los Alamos National Laboratory have developed a computer model that clarifies the complex processes driving ocean mixing in the vast eddies that swirl across hundreds of miles of open ocean. "The model enables us to study the important processes of ocean storms, which move heat and carbon from the atmosphere

  16. LOS ALAMOS, N.M., March 24, 2015-Los Alamos National Laboratory mechanical

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    computer simulation improves offshore drill rig safety March 24, 2015 LOS ALAMOS, N.M., March 24, 2015-Los Alamos National Laboratory mechanical and thermal engineering researchers' efforts to solve the complex problem of how ocean currents affect the infrastructure of floating oilrigs and their computational fluid dynamics (CFD) numerical simulations received recognition from ANSYS Inc., a company that provides computer-based engineering simulation capabilities."Because energy resources

  17. LOS ALAMOS, N.M., May 13, 2013-Today, Los Alamos National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Domestic production of medical isotope Mo-99 moves a step closer May 13, 2013 Los Alamos team produces molybdenum-99 from irradiation of low enriched uranium solution LOS ALAMOS, N.M., May 13, 2013-Today, Los Alamos National Laboratory announced that for the first time, irradiated low-enriched uranium (LEU) fuel has been recycled and reused for molybdenum-99 (Mo-99) production, with virtually no losses in Mo-99 yields or uranium recovery. This demonstrates the viability of the separation

  18. LOS ALAMOS, N.M., May 22, 2013-Los Alamos National Laboratory's Bradbury

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    partnering in national Blue Star Museums program May 22, 2013 Free admission for active duty military, their family members LOS ALAMOS, N.M., May 22, 2013-Los Alamos National Laboratory's Bradbury Science Museum is again partnering with the National Endowment for the Arts, Blue Star Families Foundation and the Department of Defense in the Blue Star Museums program to host active duty military personnel and their families from Memorial Day, May 27, through Labor Day, Sept. 2. "In this the

  19. LOS ALAMOS, N.M., Nov. 10, 2015-Two Los Alamos National Laboratory employees

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Helping New Mexico small businesses earns recognition for Los Alamos National Lab employees November 10, 2015 Program provides access to technical expertise and laboratory capabilities LOS ALAMOS, N.M., Nov. 10, 2015-Two Los Alamos National Laboratory employees were recently recognized in an awards ceremony for providing their technical expertise and access to lab capabilities to help small businesses through the New Mexico Small Business Assistance Program. Don Quintana, a group leader within

  20. LOS ALAMOS, N.M., Nov. 19, 2013-Researchers at Los Alamos National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    virus spread and evolution studied through computer modeling November 19, 2013 LOS ALAMOS, N.M., Nov. 19, 2013-Researchers at Los Alamos National Laboratory are investigating the complex relationships between the spread of the HIV virus in a population (epidemiology) and the actual, rapid evolution of the virus (phylogenetics) within each patient's body. "We have developed novel ways of estimating epidemics dynamics such as who infected whom, and the true population incidence of infection

  1. LOS ALAMOS, N.M., Oct. 26, 2015-Scientists from Los Alamos National Laboratory,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Nanoscale, multidimensional artificial magnet created October 26, 2015 Embargoed for 10 a.m. Mountain, Oct. 26, 2015 Tiny magnets could work in sensors, information encoding LOS ALAMOS, N.M., Oct. 26, 2015-Scientists from Los Alamos National Laboratory, in collaboration with a group at the University of Illinois at Urbana-Champaign, the Lawrence Berkeley National Laboratory's Advanced Light Source and with other researchers nationwide, have realized a nanoscale, artificial magnet by arranging an

  2. LOS ALAMOS, N.M., October 9, 2012-Researchers at Los Alamos National

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    crystallography aids drug design October 9, 2012 Precisely tailored pharmaceuticals could reduce medical side effects LOS ALAMOS, N.M., October 9, 2012-Researchers at Los Alamos National Laboratory have used neutron crystallography for the first time to determine the structure of a clinical drug in complex with its human target enzyme. Seeing the detailed structure of the bonded components provides insights into developing more effective drugs with fewer side effects for patients. The atomic

  3. LOS ALAMOS, N.M., Aug. 24, 2016-Nine Los Alamos National Laboratory innovations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    impact innovations honored as R&D 100 Award finalists August 24, 2016 Nine technologies offer breakthroughs in energy, computing, cybersecurity, health, materials and particle accelerators LOS ALAMOS, N.M., Aug. 24, 2016-Nine Los Alamos National Laboratory innovations were selected as finalists for the 2016 R&D 100 Awards, which honor the top 100 proven technological advances of the past year as determined by a panel selected by R&D Magazine. The finalists, with projects covering

  4. Change LOS ALAMOS, N.M., May 19, 2015-Researchers at Los Alamos National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Drought-induced tree mortality accelerating in forests May 19, 2015 Los Alamos' paper published in Nature Climate Change LOS ALAMOS, N.M., May 19, 2015-Researchers at Los Alamos National Laboratory have found that drought and heat-induced tree mortality is accelerating in many forest biomes as a consequence of a warming climate in their paper "Darcy's law predicts widespread forest mortality under climate warming," published in the journal Nature Climate Change. "The warming

  5. New Zone Plate for Soft X-Ray Microscopy at 15-nm Spatial Resolution

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    New Zone Plate for Soft X-Ray Microscopy at 15-nm Spatial Resolution Print Analytical tools that combine spatial resolution with elemental and chemical identification at the nanometer scale along with large penetration depth are indispensable for the life and physical sciences. The XM-1 soft x-ray microscope at the ALS produces images that not only reveal structures but can identify their chemical elements and measure magnetic and other properties as well. Now a new method for creating optical

  6. New Zone Plate for Soft X-Ray Microscopy at 15-nm Spatial Resolution

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    New Zone Plate for Soft X-Ray Microscopy at 15-nm Spatial Resolution Print Analytical tools that combine spatial resolution with elemental and chemical identification at the nanometer scale along with large penetration depth are indispensable for the life and physical sciences. The XM-1 soft x-ray microscope at the ALS produces images that not only reveal structures but can identify their chemical elements and measure magnetic and other properties as well. Now a new method for creating optical

  7. DOE Zero Energy Ready Home Case Study 2013: Palo Duro Homes, Inc., Albuquerque, NM

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Palo Duro Homes, Inc. Albuquerque, NM BUILDING TECHNOLOGIES OFFICE The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specifi ed in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR for Homes Version 3 for an energy-effi cient home built on a solid foundation of building science research. Advanced technologies are designed in to give you

  8. FINAL REPORT INTEGRATED DM1200 MELTER TESTING OF REDOX EFFECTS USING HLW AZ-101 AND C-106/AY-102 SIMULANTS VSL-04R4800-1 REV 0 5/6/

    SciTech Connect (OSTI)

    KRUGER AA; MATLACK KS; GONG W; BARDAKCI T; D'ANGELO NA; LUTZE W; BIZOT PM; CALLOW RA; BRANDYS M; KOT WK; PEGG IL

    2011-12-29

    This report documents melter and off-gas performance results obtained on the DM1200 HLW Pilot Melter during processing of AZ-101 and C-106/AY-102 HLW simulants. The tests reported herein are a subset of three tests from a larger series of tests described in the Test Plan for the work; results from the remaining tests will be reported separately. Three nine day tests, one with AZ-101 and two with C-106/AY-102 feeds were conducted with variable amounts of added sugar to address the effects of redox. The test with AZ-101 included ruthenium spikes to also address the effects of redox on ruthenium volatility. One of tests addressed the effects of increased flow-sheet nitrate levels using C-106/AY-102 feeds. With high nitrate/nitrite feeds (such as WTP LAW feeds), reductants are required to prevent melt foaming and deleterious effects on glass production rates. Sugar is the baseline WTP reductant for this purpose. WTP HLW feeds typically have relatively low nitrate/nitrite content in comparison to the organic carbon content and, therefore, have typically not required sugar additions. However, HLW feed variability, particularly with respect to nitrate levels, may necessitate the use of sugar in some instances. The tests reported here investigate the effects of variable sugar additions to the melter feed as well as elevated nitrate levels in the waste. Variables held constant to the extent possible included melt temperature, bubbling rate, plenum temperature, cold cap coverage, the waste simulant composition, and the target glass composition. The principal objectives of the DM1200 melter testing were to determine the achievable glass production rates for simulated HLW feeds with variable amounts of added sugar and increased nitrate levels; characterize melter off-gas emissions; characterize the performance of the prototypical off-gas system components as well as their integrated performance; characterize the feed, glass product, and off-gas effluents; and perform pre- and

  9. Effects of amines on formation of sub-3 nm particles and their subsequent growth

    SciTech Connect (OSTI)

    Yu H.; McGraw R.; Lee S.-H.

    2012-01-28

    Field observations and quantum chemical calculations suggest that amines can be important for formation of nanometer size particles. Amines and ammonia often have common atmospheric emission sources and the similar chemical and physical properties. While the effects of ammonia on aerosol nucleation have been previously investigated, laboratory studies of homogeneous nucleation involving amines are lacking. We have made kinetics studies of multicomponent nucleation (MCN) with sulfuric acid, water, ammonia and amines under conditions relevant to the atmosphere. Low concentrations of aerosol precursors were measured with chemical ionization mass spectrometers (CIMS) to provide constrained precursor concentrations needed for nucleation. Particle sizes larger than {approx}2 nm were measured with a nano-differential mobility analyzer (nano-DMA), and number concentrations of particles larger than {approx}1 nm were measured with a particle size magnifier (PSM). Our observations provide the laboratory evidence that amines indeed can participate in aerosol nucleation and growth at the molecular cluster level. The enhancement of particle number concentrations due to several atmospherically relevant amine compounds and ammonia were related to the basicity of these compounds, indicating that acid-base reactions may contribute to the formation of sub-3 nm particles.

  10. Size dependent compressibility of nano-ceria: Minimum near 33 nm

    SciTech Connect (OSTI)

    Rodenbough, Philip P.; Song, Junhua; Chan, Siu-Wai; Walker, David; Clark, Simon M.; Kalkan, Bora

    2015-04-20

    We report the crystallite-size-dependency of the compressibility of nanoceria under hydrostatic pressure for a wide variety of crystallite diameters and comment on the size-based trends indicating an extremum near 33 nm. Uniform nano-crystals of ceria were synthesized by basic precipitation from cerium (III) nitrate. Size-control was achieved by adjusting mixing time and, for larger particles, a subsequent annealing temperature. The nano-crystals were characterized by transmission electron microscopy and standard ambient x-ray diffraction (XRD). Compressibility, or its reciprocal, bulk modulus, was measured with high-pressure XRD at LBL-ALS, using helium, neon, or argon as the pressure-transmitting medium for all samples. As crystallite size decreased below 100 nm, the bulk modulus first increased, and then decreased, achieving a maximum near a crystallite diameter of 33 nm. We review earlier work and examine several possible explanations for the peaking of bulk modulus at an intermediate crystallite size.

  11. Validation of the MCNPX-PoliMi Code to Design a Fast-Neutron Multiplicity Counter

    SciTech Connect (OSTI)

    J. L. Dolan; A. C. Kaplan; M. Flaska; S. A. Pozzi; D. L. Chichester

    2012-07-01

    Many safeguards measurement systems used at nuclear facilities, both domestically and internationally, rely on He-3 detectors and well established mathematical equations to interpret coincidence and multiplicity-type measurements for verifying quantities of special nuclear material. Due to resource shortages alternatives to these existing He-3 based systems are being sought. Work is also underway to broaden the capabilities of these types of measurement systems in order to improve current multiplicity analysis techniques. As a part of a Material Protection, Accounting, and Control Technology (MPACT) project within the U.S. Department of Energy's Fuel Cycle Technology Program we are designing a fast-neutron multiplicity counter with organic liquid scintillators to quantify important quantities such as plutonium mass. We are also examining the potential benefits of using fast-neutron detectors for multiplicity analysis of advanced fuels in comparison with He-3 detectors and testing the performance of such designs. The designs are being developed and optimized using the MCNPX-PoliMi transport code to study detector response. In the full paper, we will discuss validation measurements used to justify the use of the MCNPX-PoliMi code paired with the MPPost multiplicity routine to design a fast neutron multiplicity counter with liquid scintillators. This multiplicity counter will be designed with the end goal of safeguarding advanced nuclear fuels. With improved timing qualities associated with liquid scintillation detectors, we can design a system that is less limited by nuclear materials of high activities. Initial testing of the designed system with nuclear fuels will take place at Idaho National Laboratory in a later stage of this collaboration.

  12. T-1025 IU SciBath-768 detector tests in MI-12

    SciTech Connect (OSTI)

    Tayloe, Rex; Cooper, R.; Garrison, L.; Thornton, T.; Rebenitsch, L.; DeJongh, Fritz; Loer, Benjamin; Ramberg, Erik; Yoo, Jonghee; /Fermilab

    2012-02-11

    This is a memorandum of understanding between the Fermi National Accelerator Laboratory (Fermilab) and the experimenters of Department of Physics and Center for Exploration of Energy and Matter, Indiana University, who have committed to participate in detector tests to be carried out during the 2012 Fermilab Neutrino program. The memorandum is intended solely for the purpose of recording expectations for budget estimates and work allocations for Fermilab, the funding agencies and the participating institutions. it reflects an arrangement that currently is satisfactory to the parties; however, it is recognized and anticipated that changing circumstances of the evolving research program will necessitate revisions. The parties agree to modify this memorandum to reflect such required adjustments. Actual contractual obligations will be set forth in separate documents. The experimenters propsoe to test their prototype 'SciBat-768' detector in the MI-12 building for 3 months (February-April) in Spring 2012. The major goal of this effort is to measure or limit the flux of beam-induced neutrons in a far-off-axis (> 45{sup o}) location of the Booster Neutrino Beamline (BNB). This flux is of interest for a proposed coherent neutral-current neutrino-argon elastic scattering experiment. A second goal is to collect more test data for the SciBath-768 to enable better understanding and calibration of the device. The SciBath-768 detector successfully ran for 3 months in the MINOS Underground Area in Fall 2011 as testbeam experiment T-1014 and is currently running above ground in the MINOS service building. For the run proposed here, the experiments are requesting: space in MI-12 in which to run the SciBath detector during February-April 2012 while the BNB is operating; technical support to help with moving the equipment on site; access to power, internet, and accelerator signals; and a small office space from which to run and monitor the experiment.

  13. Scientists to Meet in Carlsbad, NM for Hard Rock Lab Task Force

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Scientists From Nine Countries to Converge On Carlsbad for Technical Meeting CARLSBAD, N.M., February 7, 2000 - Scientists from nine countries will converge on this southeastern New Mexico city February 7-10 to share their views during the 13 th Äspö Hard Rock Laboratory Task Force Meeting on Modelling of Groundwater Flow and Transport of Solutes. "Carlsbad is quickly becoming recognized as the international center for repository technology," said Dr. Inés Triay, manager of the U.S.

  14. Other Locales W. Clements Los Alamos National Laboratory Los Alamos, NM 87545

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    W. Clements Los Alamos National Laboratory Los Alamos, NM 87545 T. Ackerman Pennsylvania State University University Park, PA 16802 D. Renne National Renewable Energy Laboratory Golden, CO 80401-3393 The Tropical Western Pacific Locale 100 S to 100 N of the equator and from 1300 E to the dateline. Phased implementation is scheduled to begin in late 1993. The main activity of the TWP project in the next year is to define the particular science to be conducted and to select an appropriate site or

  15. LOS ALAMOS, N.M., Aug. 21, 2013-The High-Altitude Water Cherenkov (HAWC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    gamma-ray observatory begins operations at Sierra Negra volcano in the state of Puebla, Mexico August 21, 2013 New site to observe supernovas and supermassive black holes LOS ALAMOS, N.M., Aug. 21, 2013-The High-Altitude Water Cherenkov (HAWC) Gamma Ray Observatory has begun formal operations at its site in Mexico. HAWC is designed to study the origin of very high-energy cosmic rays and observe the most energetic objects in the known universe. This extraordinary observatory, using a unique

  16. LOS ALAMOS, N.M., August 7, 2013-Los Alamos National Laboratory scientist

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lab's Frontiers in Science lectures focus on epigenetics August 7, 2013 Is behavior hardwired by DNA or a product of environment? LOS ALAMOS, N.M., August 7, 2013-Los Alamos National Laboratory scientist Karissa Sanbonmatsu, will discuss epigenetics in a series of Frontiers in Science lectures beginning Tuesday, Aug. 13, at the New Mexico Museum of Natural History and Science in Albuquerque. The 7 p.m. talk, titled "Nature, Nurture or Neither: The New Science of Epigenetics," focuses

  17. LOS ALAMOS, N.M., Dec. 14, 2015-Los Alamos National Laboratory's portable

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    named Top 10 Breakthrough of 2015 by Physics World magazine December 20, 2015 LOS ALAMOS, N.M., Dec. 14, 2015-Los Alamos National Laboratory's portable MRI was named one of the Top 10 Breakthroughs of the Year by Physics World, the member magazine of the Institute of Physics. Portable MRI, also called Battlefield MRI (bMRI), uses ultra-low-field magnetic resonance imaging to create images of injured soft tissues, such as the brain. "Hospital-based MRI devices are big and expensive,"

  18. LOS ALAMOS, N.M., January 15, 2013-Researchers from Los Alamos National

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    follows the 'Yellowknife Road' to Martian wet area January 15, 2013 Instrument confirms presence of gypsum and related minerals LOS ALAMOS, N.M., January 15, 2013-Researchers from Los Alamos National Laboratory and the French Space Agency have tracked a trail of minerals that point to the prior presence of water at the Curiosity rover site on Mars. Researchers from the Mars Science Laboratory's ChemCam team today described how the laser instrument aboard the Curiosity Rover-an SUV-sized vehicle

  19. LOS ALAMOS, N.M., July 12, 2013 - Los Alamos National Laboratory Director

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Importance of science education to national security will be Los Alamos director's topic at TEDxABQ July 12, 2013 Importance of science education to national security will be Los Alamos director's topic at TEDxABQ LOS ALAMOS, N.M., July 12, 2013 - Los Alamos National Laboratory Director Charlie McMillan will be one of 17 speakers at this year's TEDxABQ, event organizers announced this week. TEDxABQ, scheduled for Saturday, September 7 at Popejoy Hall, is an independently organized event in

  20. LOS ALAMOS, N.M., July 27, 2015- Four Los Alamos National Laboratory projects

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Los Alamos projects selected as R&D 100 Award finalists July 27, 2015 LOS ALAMOS, N.M., July 27, 2015- Four Los Alamos National Laboratory projects have been selected as finalists for the 2015 R&D 100 awards, which honor the top 100 proven technological advances of the past year as determined by a panel selected by R&D Magazine. The Los Alamos finalists are: LARS: Lab-scale Asynchronous Radiographic System, PipeLIBS: A Self-Contained Elemental Analysis Tool for the Oil Industry,

  1. LOS ALAMOS, N.M., March 18, 2015-Scientists at Los Alamos National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    creates bioinformatics tool for metagenome analysis March 18, 2015 'GOTTCHA' tool could aid ID of co-infections in medical samples LOS ALAMOS, N.M., March 18, 2015-Scientists at Los Alamos National Laboratory have developed a new method for DNA analysis of microbial communities such as those found in the ocean, the soil, and our own guts. "Metagenomics is the study of entire microbial communities using genomics, such as when you sequence the DNA of a whole community of organisms at

  2. LOS ALAMOS, N.M., March 31, 2014-Los Alamos National Laboratory climate

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Forests and climate change focus of Frontiers in Science lectures March 31, 2014 It's not easy staying green... LOS ALAMOS, N.M., March 31, 2014-Los Alamos National Laboratory climate researcher Nate McDowell will discuss climate change and its effects on forest systems in a series of Frontiers in Science lectures beginning Wednesday, April 2 at the New Mexico Museum of Natural History and Science in Albuquerque. "The data we have suggests that forests of the Southwest and many other areas

  3. LOS ALAMOS, N.M., Nov. 3, 2015-Nina Lanza, of Los Alamos National Laboratory's

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hunting for meteorites in Antarctica November 3, 2015 Los Alamos scientist part of NASA's select few LOS ALAMOS, N.M., Nov. 3, 2015-Nina Lanza, of Los Alamos National Laboratory's Space and Remote Sensing group, was selected as one of eight members for the 2015-2016 field campaign of the Antarctica Search for Meteorites (ANSMET) program, which is supported by NASA. "These meteorites can help us understand the formation and evolution of our solar system," said Lanza. "They come

  4. LOS ALAMOS, N.M., Oct. 22, 2015-Los Alamos National Laboratory explosives

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Rings of Fire: New explosives provide enhanced safety, high energy October 22, 2015 LOS ALAMOS, N.M., Oct. 22, 2015-Los Alamos National Laboratory explosives chemist David Chavez has synthesized a pair of novel molecules, one possessing a unique fused three-ring structure. These materials could usher in a new class of explosives that provide high-energy output with enhanced safety. "There is a general trend that the higher the performance of an energetic material, the more sensitive the

  5. LOS ALAMOS, N.M., Oct. 23, 2014-Los Alamos National Laboratory scientists

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    rocket design flight tested October 23, 2014 New rocket propellant and motor design offers high performance and safety LOS ALAMOS, N.M., Oct. 23, 2014-Los Alamos National Laboratory scientists recently flight tested a new rocket design that includes a high-energy fuel and a motor design that also delivers a high degree of safety. "What we're trying to do is break the performance versus sensitivity curve, and make a rocket that's both very high-energy, as well as very safe," said Bryce

  6. LOS ALAMOS, N.M., Oct. 31, 2013-Los Alamos National Laboratory scientist

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Matter, antimatter and surviving the big bang is topic of Lab's next Frontiers in Science lecture October 31, 2013 Talk begins at 7 p.m. and open to public LOS ALAMOS, N.M., Oct. 31, 2013-Los Alamos National Laboratory scientist Vincenzo Cirigliano asks the question, How did we survive the big bang? in a series of Frontiers in Science lectures beginning Monday, Nov. 4, in the Duane Smith Auditorium at Los Alamos High School. "Particles and antiparticles were produced in equal numbers in the

  7. LOS ALAMOS, N.M., Sept. 17, 2015-Scientists at Los Alamos National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    insights into HIV-1 vaccine design September 17, 2015 Los Alamos researchers model alternate ideas for an HIV vaccine LOS ALAMOS, N.M., Sept. 17, 2015-Scientists at Los Alamos National Laboratory have created a computational model that could change the way that researchers look at possibilities for an HIV-1 vaccine. "An effective HIV-1 vaccine has proven elusive, partly due to the difficulty of causing an immune response that can neutralize the diverse viral strains circulating in the human

  8. Poly(ethylene terephthalate) surface modification by deep UV (172 nm) irradiation

    SciTech Connect (OSTI)

    Zhengmao Zhua; Michael J. Kelley

    2004-09-01

    The prospects of obtaining desired surface-mediated characteristics while retaining bulk-mediated physical properties and avoiding potential environmental issues with wet chemical technology lends considerable appeal to photochemical approaches. We investigated the response of poly(ethylene terephthalate) to 172 nm UV from a xenon excimer lamp in the absence of oxygen, using XPS, ToF/SIMS, and AFM. The main effects are increasing loss of a C=O moiety and carboxylic acid production without effect on topography up to a total fluence of 16 J/cm2. Above this level no further change in surface chemistry was evident, but surfaces became rougher, suggesting the onset of etching.

  9. 1-nm-thick graphene tri-layer as the ultimate copper diffusion barrier

    SciTech Connect (OSTI)

    Nguyen, Ba-Son [Department of Mechanical Engineering, National Cheng Kung University, 1 University Road, Tainan 701, Taiwan (China); Lin, Jen-Fin [Department of Mechanical Engineering, National Cheng Kung University, 1 University Road, Tainan 701, Taiwan (China); Center for Micro/Nano Science and Technology, National Cheng Kung University, 1 University Road, Tainan 701, Taiwan (China); Perng, Dung-Ching, E-mail: dcperng@ee.ncku.edu.tw [Institute of Microelectronics and Electrical Engineering Department, National Cheng Kung University, 1 University Road, Tainan 701, Taiwan (China); Center for Micro/Nano Science and Technology, National Cheng Kung University, 1 University Road, Tainan 701, Taiwan (China)

    2014-02-24

    We demonstrate the thinnest ever reported Cu diffusion barrier, a 1-nm-thick graphene tri-layer. X-ray diffraction patterns and Raman spectra show that the graphene is thermally stable at up to 750?C against Cu diffusion. Transmission electron microscopy images show that there was no inter-diffusion in the Cu/graphene/Si structure. Raman analyses indicate that the graphene may have degraded into a nanocrystalline structure at 750?C. At 800?C, the perfect carbon structure was damaged, and thus the barrier failed. The results of this study suggest that graphene could be the ultimate Cu interconnect diffusion barrier.

  10. Damage thresholds of thin film materials and high reflectors at 248 nm

    SciTech Connect (OSTI)

    Rainer, F.; Lowdermilk, W.H.; Milam, D.; Carniglia, C.K.; Hart, T.T.; Lichtenstein, T.L.

    1982-01-01

    Twenty-ns, 248-nm KrF laser pulses were used to measure laser damage thresholds for halfwave-thick layers of 15 oxide and fluoride coating materials, and for high reflectance coatings made with 13 combinations of these materials. The damage thresholds of the reflectors and single-layer films were compared to measurements of several properties of the halfwave-thick films to determine whether measurements of these properties of single-layer films to determine whether measurements of these properties of single-layer films were useful for identifying materials for fabrication of damage resistant coatings.

  11. Picosecond 14.7 nm interferometry of high intensity laser-produced plasmas

    SciTech Connect (OSTI)

    Dunn, J; Filevich, J; Smith, R F; Moon, S J; Rocca, J J; Keenan, R; Nilsen, J; Shlyaptsev, V N; Hunter, J R; Ng, A; Marconi, M C

    2004-10-14

    We have developed a compact, 14.7 nm, sub-5 ps x-ray laser source at LLNL together with a Mach-Zehnder type Diffraction Grating Interferometer built at Colorado State University for probing dense, high intensity laser-produced plasmas. The short wavelength and pulse length of the probe reduces refraction and absorption effects within the plasma and minimizes plasma motion blurring. This unique diagnostic capability gives precise 2-D density profile snapshots and is generating new data for rapidly evolving laser-heated plasmas. A review of the results from dense, mm-scale line focus plasma experiments will be described with detailed comparisons to hydrodynamic simulations.

  12. CY08 SNL_NM ASER_8_10_09.indb

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    //IA * .~ r'fIA \b1i Sandia Site Office ///IV&.~~~ National Nuclear Security Administration P.o. Box 5400 Albuquerque, New Mexico 87185-5400 AUG 262009 To Distribution: Enclosed is a copy of the Calendar Year (CY) 2008 Annual Site Environmental Report for the U. S. Department of Energy (DOE), National Nuclear Security Administration (NNSA), Sandia National Laboratories/Nev..: rV:iexico (SNL/NM) for your use as appropriate. This report has recently been approved for public distribution. The

  13. Nonlinear bleaching, absorption, and scattering of 532-nm-irradiated plasmonic nanoparticles

    SciTech Connect (OSTI)

    Liberman, V.; Sworin, M.; Kingsborough, R. P.; Geurtsen, G. P.; Rothschild, M.

    2013-02-07

    Single-pulse irradiation of Au and Ag suspensions of nanospheres and nanodisks with 532-nm 4-ns pulses has identified complex optical nonlinearities while minimizing material damage. For all materials tested, we observe competition between saturable absorption (SA) and reverse SA (RSA), with RSA behavior dominating for intensities above {approx}50 MW/cm{sup 2}. Due to reduced laser damage in single-pulse experiments, the observed intrinsic nonlinear absorption coefficients are the highest reported to date for Au nanoparticles. We find size dependence to the nonlinear absorption enhancement for Au nanoparticles, peaking in magnitude for 80-nm nanospheres and falling off at larger sizes. The nonlinear absorption coefficients for Au and Ag spheres are comparable in magnitude. On the other hand, the nonlinear absorption for Ag disks, when corrected for volume fraction, is several times higher. These trends in nonlinear absorption are correlated to local electric field enhancement through quasi-static mean-field theory. Through variable size aperture measurements, we also separate nonlinear scattering from nonlinear absorption. For all materials tested, we find that nonlinear scattering is highly directional and that its magnitude is comparable to that of nonlinear absorption. These results indicate methods to improve the efficacy of plasmonic nanoparticles as optical limiters in pulsed laser systems.

  14. Quantum yield for carbon monoxide production in the 248 nm photodissociation of carbonyl sulfide (OCS)

    SciTech Connect (OSTI)

    Zhao, Z.; Stickel, R.E.; Wine, P.H. [Georgia Institute of Technology, Atlanta, GA (United States)] [Georgia Institute of Technology, Atlanta, GA (United States)

    1995-03-01

    Tunable diode laser absorption spectroscopy has been coupled with excimer laser flash photolysis to measure the quantum yield for CO production from 248 nm photodissociation of carbonyl sulfide (OCS) relative to the well known quantum yield for CO production from 248 nm photolysis of phosgene (Cl{sub 2}CO). The temporal resolution of the experiments was sufficient to distinguish CO formed directly by photodissociation from that formed by subsequent S({sup 3}P{sub j}) reaction with OCS. Under the experimental conditions employed, CO formation via the fast S({sup 1}D{sub 2})+OCS reaction was minimal. Measurements at 297K and total pressures from 4 to 100 Torr N{sub 2}+N{sub 2}O show the CO yield to be greater than 0.95 and most likely unity. This result suggests that the contribution of OCS as a precursor to the lower stratospheric sulfate aerosol layer is somewhat larger than previously thought. 25 refs., 1 fig., 2 tabs.

  15. paper-LSPP16

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    FL PADD 4: Rocky Mountain PADD 5: West Coast PADD 2: Midwest PADD 1: East Coast PADD 3: Gulf Coast PADD1A: New England PADD1B: Central Atlantic PADD1C: Lower Atlantic Petroleum Administration for Defense Districts AK HI WA OR CA NV AZ MT WY CO UT ID ND SD NE KS OK MO MN WI MI IL IN OH KY TN IA NM TX AR LA AL MS WV VA NC SC GA FL ME NH VT NY PA NJ MD DE MA CT RI

    pantex On Womens Equality Day, we celebrate NNSA's talented Women in STEM NNSA's systems administrators keep the computers running

  16. padd map

    U.S. Energy Information Administration (EIA) Indexed Site

    FL PADD 4: Rocky Mountain PADD 5: West Coast PADD 2: Midwest PADD 1: East Coast PADD 3: Gulf Coast PADD1A: New England PADD1B: Central Atlantic PADD1C: Lower Atlantic Petroleum Administration for Defense Districts AK HI WA OR CA NV AZ MT WY CO UT ID ND SD NE KS OK MO MN WI MI IL IN OH KY TN IA NM TX AR LA AL MS WV VA NC SC GA FL ME NH VT NY PA NJ MD DE MA CT RI

  17. printer_friendly_org_chart

    Gasoline and Diesel Fuel Update (EIA)

    FL PADD 4: Rocky Mountain PADD 5: West Coast PADD 2: Midwest PADD 1: East Coast PADD 3: Gulf Coast PADD1A: New England PADD1B: Central Atlantic PADD1C: Lower Atlantic Petroleum Administration for Defense Districts AK HI WA OR CA NV AZ MT WY CO UT ID ND SD NE KS OK MO MN WI MI IL IN OH KY TN IA NM TX AR LA AL MS WV VA NC SC GA FL ME NH VT NY PA NJ MD DE MA CT RI

    Administrator U.S. Energy Information Administration Adam Sieminski Deputy Administrator Howard Gruenspecht Assistant Administrator

  18. Buildings Energy Data Book: 3.9 Educational Facilities

    Buildings Energy Data Book [EERE]

    6 2010 Regional New Construction and Renovations Expenditures for Public K-12 Schools ($Million) Region New Schools Additions Renovation Total Region 1 (CT, MA, ME, NH, RI, VT) Region 2 (NJ, NY, PA) Region 3 (DE, MD, VA, WV) Region 4 (KY, NC, SC, TN) Region 5 (AL, FL, GA, MS) Region 6 (IN, MI, OH) Region 7 (IL, MN, WI) Region 8 (IA, KS, MO, NE) Region 9 (AR, LA, OK, TX) Region 10 (CO, MT, ND, NM, SD, UT, WY) Region 11 (AZ, CA, HI, NV) Region 12 (AK, ID, OR, WA) Total Source(s): School Planning

  19. DOE Hydrogen and Fuel Cell Overview

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    DOE Hydrogen & Fuel Cell Overview Dr. Sunita Satyapal Program Manager U.S. Department of Energy Fuel Cell Technologies Program DOE/CESA/TTC Hydrogen and Fuel Cells Webinar December 14, 2010 2 Examples of DOE-funded Partners and Locations - Fuel Cell Technologies Program TX NM AZ NC AR CA CO HI WA IL KY MA MN MO MS AL NV TN UT WV ID FL MI ND OR OH IN MT WY IO NE KS OK AK LA GA WI SC VA PA DE MD DC NJ NY RI CT VT NH ME SD Source: US DOE 12/2010 2 3 Fuel Cells: Addressing Energy Challenges 4

  20. Print

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    < 5k 0 < 50k < 100k < 250k < 500k < 1M > 1M > 5M > 10M DE MD DC MA RI NJ AZ UT WY ID OR WA CA TX OK KS CO NE SD ND MN WI IL IA MO AR LA MS AL FL GA TN KY IN OH MI ME NH CT VT NY PA WV VA NC SC MT AK HI NV NM Princeton Plasma Physics Laboratory Procured Materials and Services 2015 (> $35M) Small business procurements in US: $14.73M

  1. Department of Energy (DOE) OpenNet documents

    Office of Scientific and Technical Information (OSTI)

    Account Request *First Name: *Last Name: *Organization: *Phone: *Email: Fax: *Address: *City: *State: Select AL AK AZ AR CA CO CT DE DC FL GA HI ID IL IN IA KS KY LA ME MD MA MI MN MS MO MT NE NV NH NJ NM NY NC ND OH OK OR PA RI SC SD TN TX UT VT VA WA WV WI WY Zip Code: *Affiliation: Select Federal Contractor *Access Level: Select View Release Official Releasing Official: release *Site Input Code: Select A2EDAP - Atmosphere to Electrons (A2e) Data Archive and Portal, Pacific Northwest National

  2. Noise behavior of a 180-nm CMOS SOI technology for detector front-end electronics

    SciTech Connect (OSTI)

    Re, Valerio; Gaioni, Luigi; Manghisoni, Massimo; Ratti, Lodovico; Speziali, Valeria; Traversi, Gianluca; Yarema, Ray; /Fermilab

    2008-01-01

    This paper is motivated by the growing interest of the detector and readout electronics community towards silicon-on-insulator CMOS processes. Advanced SOI MOSFETs feature peculiar electrical characteristics impacting their performance with respect to bulk CMOS devices. Here we mainly focus on the study of these effects on the noise parameters of the transistors, using experimental data relevant to 180 nm fully depleted SOI devices as a reference. The comparison in terms of white and 1/f noise components with bulk MOSFETs with the same minimum feature size gives a basis of estimate for the signal-to-noise ratio achievable in detector front-end integrated circuits designed in an SOI technology.

  3. Time and spectrum-resolving multiphoton correlator for 300900 nm

    SciTech Connect (OSTI)

    Johnsen, Kelsey D.; Thibault, Marilyne; Jennewein, Thomas; Kolenderski, Piotr; Scarcella, Carmelo; Tosi, Alberto

    2014-10-14

    We demonstrate a single-photon sensitive spectrometer in the visible range, which allows us to perform time-resolved and multi-photon spectral correlation measurements at room temperature. It is based on a monochromator composed of two gratings, collimation optics, and an array of single photon avalanche diodes. The time resolution can reach 110 ps and the spectral resolution is 2 nm/pixel, limited by the design of the monochromator. This technique can easily be combined with commercial monochromators and can be useful for joint spectrum measurements of two photons emitted in the process of parametric down conversion, as well as time-resolved spectrum measurements in optical coherence tomography or medical physics applications.

  4. 1.5 nm fabrication of test patterns for characterization of metrological systems

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Babin, Sergey; Calafiore, Giuseppe; Peroz, Christophe; Conley, Raymond; Bouet, Nathalie; Cabrini, Stefano; Chan, Elaine; Lacey, Ian; McKinney, Wayne R.; Yashchuk, Valeriy V.; et al

    2015-11-06

    Any metrology tool is only as good as it is calibrated. The characterization of metrology systems requires test patterns at a scale about ten times smaller than the measured features. The fabrication of patterns with linewidths down to 1.5 nm is described. The test sample was designed in such a way that the distribution of linewidths appears to be random at any location. This pseudorandom test pattern is used to characterize dimensional metrology equipment over its entire dynamic range by extracting the modulation transfer function of the system. The test pattern contains alternating lines of silicon and tungsten silicide, eachmore » according to its designed width. As a result, the fabricated test samples were imaged using a transmission electron microscope, a scanning electron microscope, and an atomic force microscope. (C) 2015 American Vacuum Society.« less

  5. 1.5 nm fabrication of test patterns for characterization of metrological systems

    SciTech Connect (OSTI)

    Babin, Sergey; Calafiore, Giuseppe; Peroz, Christophe; Conley, Raymond; Bouet, Nathalie; Cabrini, Stefano; Chan, Elaine; Lacey, Ian; McKinney, Wayne R.; Yashchuk, Valeriy V.; Vladar, Andras E.

    2015-11-06

    Any metrology tool is only as good as it is calibrated. The characterization of metrology systems requires test patterns at a scale about ten times smaller than the measured features. The fabrication of patterns with linewidths down to 1.5 nm is described. The test sample was designed in such a way that the distribution of linewidths appears to be random at any location. This pseudorandom test pattern is used to characterize dimensional metrology equipment over its entire dynamic range by extracting the modulation transfer function of the system. The test pattern contains alternating lines of silicon and tungsten silicide, each according to its designed width. As a result, the fabricated test samples were imaged using a transmission electron microscope, a scanning electron microscope, and an atomic force microscope. (C) 2015 American Vacuum Society.

  6. Ion generation and CPC detection efficiency studies in sub 3-nm size range

    SciTech Connect (OSTI)

    Kangasluoma, J.; Junninen, H.; Sipilae, M.; Kulmala, M.; Petaejae, T.; Lehtipalo, K.; Mikkilae, J.; Vanhanen, J.; Attoui, M.; Worsnop, D.

    2013-05-24

    We studied the chemical composition of commonly used condensation particle counter calibration ions with a mass spectrometer and found that in our calibration setup the negatively charged ammonium sulphate, sodium chloride and tungsten oxide are the least contaminated whereas silver on both positive and negative and the three mentioned earlier in positive mode are contaminated with organics. We report cut-off diameters for Airmodus Particle Size Magnifier (PSM) 1.1, 1.3, 1.4, 1.6 and 1.6-1.8 nm for negative sodium chloride, ammonium sulphate, tungsten oxide, silver and positive organics, respectively. To study the effect of sample relative humidity on detection efficiency of the PSM we used different humidities in the differential mobility analyzer sheath flow and found that with increasing relative humidity also the detection efficiency of the PSM increases.

  7. Wavelength and Intensity Dependence of Short Pulse Laser Xenon Double Ionization between 500 and 2300 nm

    SciTech Connect (OSTI)

    Gingras, G.; Tripathi, A.; Witzel, B.

    2009-10-23

    The wavelength and intensity dependence of xenon ionization with 50 fs laser pulses has been studied using time-of-flight mass spectrometry. We compare the ion yield distribution of singly and doubly charged xenon with the Perelomov-Popov-Terent'ev (PPT) theory, Perelomov, Popov, and Terent'ev, Zh. Eksp. Teor. Fiz. 50, 1393 (1966) [Sov. Phys. JETP 23, 924 (1966)], in the regime between 500 and 2300 nm. The intensity dependence for each wavelength is measured in a range between 1x10{sup 13} and 1x10{sup 15} W/cm{sup 2}. The Xe{sup +}-ion signal is in good agreement with the PPT theory at all used wavelengths. In addition we demonstrate that ionic 5s5p{sup 6} {sup 2}S state is excited by an electron impact excitation process and contributes to the nonsequential double ionization process.

  8. High power terahertz generation using 1550 nm plasmonic photomixers

    SciTech Connect (OSTI)

    Berry, Christopher W.; Hashemi, Mohammad R.; Jarrahi, Mona; Preu, Sascha; Lu, Hong; Gossard, Arthur C.

    2014-07-07

    We present a 1550 nm plasmonic photomixer operating under pumping duty cycles below 10%, which offers significantly higher terahertz radiation power levels compared to previously demonstrated photomixers. The record-high terahertz radiation powers are enabled by enhancing the device quantum efficiency through use of plasmonic contact electrodes, and by mitigating thermal breakdown at high optical pump power levels through use of a low duty cycle optical pump. The repetition rate of the optical pump can be specifically selected at a given pump duty cycle to control the spectral linewidth of the generated terahertz radiation. At an average optical pump power of 150 mW with a pump modulation frequency of 1 MHz and pump duty cycle of 2%, we demonstrate up to 0.8 mW radiation power at 1 THz, within each continuous wave radiation cycle.

  9. Final report on LDRD project : single-photon-sensitive imaging detector arrays at 1600 nm.

    SciTech Connect (OSTI)

    Childs, Kenton David; Serkland, Darwin Keith; Geib, Kent Martin; Hawkins, Samuel D.; Carroll, Malcolm S.; Klem, John Frederick; Sheng, Josephine Juin-Jye; Patel, Rupal K.; Bolles, Desta; Bauer, Tom M.; Koudelka, Robert

    2006-11-01

    The key need that this project has addressed is a short-wave infrared light detector for ranging (LIDAR) imaging at temperatures greater than 100K, as desired by nonproliferation and work for other customers. Several novel device structures to improve avalanche photodiodes (APDs) were fabricated to achieve the desired APD performance. A primary challenge to achieving high sensitivity APDs at 1550 nm is that the small band-gap materials (e.g., InGaAs or Ge) necessary to detect low-energy photons exhibit higher dark counts and higher multiplication noise compared to materials like silicon. To overcome these historical problems APDs were designed and fabricated using separate absorption and multiplication (SAM) regions. The absorption regions used (InGaAs or Ge) to leverage these materials 1550 nm sensitivity. Geiger mode detection was chosen to circumvent gain noise issues in the III-V and Ge multiplication regions, while a novel Ge/Si device was built to examine the utility of transferring photoelectrons in a silicon multiplication region. Silicon is known to have very good analog and GM multiplication properties. The proposed devices represented a high-risk for high-reward approach. Therefore one primary goal of this work was to experimentally resolve uncertainty about the novel APD structures. This work specifically examined three different designs. An InGaAs/InAlAs Geiger mode (GM) structure was proposed for the superior multiplication properties of the InAlAs. The hypothesis to be tested in this structure was whether InAlAs really presented an advantage in GM. A Ge/Si SAM was proposed representing the best possible multiplication material (i.e., silicon), however, significant uncertainty existed about both the Ge material quality and the ability to transfer photoelectrons across the Ge/Si interface. Finally a third pure germanium GM structure was proposed because bulk germanium has been reported to have better dark count properties. However, significant

  10. Structural distortions in 5-10 nm silver nanoparticles under high pressure

    SciTech Connect (OSTI)

    Koski, Kristie J.; Kamp, Noelle M.; Kunz, Martin; Knight, Jason K.; Alivisatos, A.P.; Smith, R.K.

    2008-10-13

    We present experimental evidence that silver nanoparticles in the size range of 5-10 nm undergo a reversible structural transformation under hydrostatic pressures up to 10 GPa. We have used x-ray diffraction with a synchrotron light source to investigate pressure-dependent and size-dependent trends in the crystal structure of silver nanoparticles in a hydrostatic medium compressed in a diamond-anvil cell. Results suggest a reversible linear pressure-dependent rhombohedral distortion which has not been previously observed in bulk silver. We propose a mechanism for this transition that considers the bond-length distribution in idealized multiply twinned icosahedral particles. To further support this hypothesis, we also show that similar measurements of single-crystal platinum nanoparticles reveal no such distortions.

  11. Dense wavelength multiplexing of 1550 nm QKD with strong classical channels in reconfigurable networking environments

    SciTech Connect (OSTI)

    Rosenberg, Danna; Peterson, Charles G; Dallmann, Nicholas; Hughes, Richard J; Mccabe, Kevin P; Nordholt, Jane E; Tyagi, Hush T; Peters, Nicholas A; Toliver, Paul; Chapman, Thomas E; Runser, Robert J; Mcnown, Scott R

    2008-01-01

    To move beyond dedicated links and networks, quantum communications signals must be integrated into networks carrying classical optical channels at power levels many orders of magnitude higher than the quantum signals themselves. We demonstrate transmission of a 1550-nm quantum channel with up to two simultaneous 200-GHz spaced classical telecom channels, using ROADM (reconfigurable optical <1dd drop multiplexer) technology for multiplexing and routing quantum and classical signals. The quantum channel is used to perform quantum key distribution (QKD) in the presence of noise generated as a by-product of the co-propagation of classical channels. We demonstrate that the dominant noise mechanism can arise from either four-wave mixing or spontaneous Raman scattering, depending on the optical path characteristics as well <1S the classical channel parameters. We quantity these impairments and discuss mitigation strategies.

  12. Sub-50 nm metrology on extreme ultra violet chemically amplified resist—A systematic assessment

    SciTech Connect (OSTI)

    Maas, D. J. Herfst, R.; Veldhoven, E. van; Fliervoet, T.; Meessen, J.; Vaenkatesan, V.; Sadeghian, H.

    2015-10-15

    With lithographic patterning dimensions decreasing well below 50 nm, it is of high importance to understand metrology at such small scales. This paper presents results obtained from dense arrays of contact holes (CHs) with various Critical Dimension (CD) between 15 and 50 nm, as patterned in a chemically amplified resist using an ASML EUV scanner and measured at ASML and TNO. To determine the differences between various (local) CD metrology techniques, we conducted an experiment using optical scatterometry, CD-Scanning Electron Microscopy (CD-SEM), Helium ion Microscopy (HIM), and Atomic Force Microscopy (AFM). CD-SEM requires advanced beam scan strategies to mitigate sample charging; the other tools did not need that. We discuss the observed main similarities and differences between the various techniques. To this end, we assessed the spatial frequency content in the raw images for SEM, HIM, and AFM. HIM and AFM resolve the highest spatial frequencies, which are attributed to the more localized probe-sample interaction for these techniques. Furthermore, the SEM, HIM, and AFM waveforms are analyzed in detail. All techniques show good mutual correlation, albeit the reported CD values systematically differ significantly. HIM systematically reports a 25% higher CD uniformity number than CD-SEM for the same arrays of CHs, probably because HIM has a higher resolution than the CD-SEM used in this assessment. A significant speed boost for HIM and AFM is required before these techniques are to serve the demanding industrial metrology applications like optical critical dimension and CD-SEM do nowadays.

  13. The photodissociation of oxetane at 193 nm as the reverse of the Paterno-Buchi reaction

    SciTech Connect (OSTI)

    Lee, Shih-Huang

    2009-12-14

    We investigated the photodissociation of oxetane (1,3-trimethylene oxide) at 193.3 nm in a molecular-beam apparatus using photofragment-translational spectroscopy and selective photoionization. We measured time-of-flight (TOF) spectra and angular anisotropy parameters {beta}(t) as a function of flight time of products at m/z=26-30 u utilizing photoionization energies from 9.8 to 14.8 eV. The TOF distributions of the products alter greatly with the employed photon energy, whereas their {beta}(t) distributions are insensitive to the photon energy. Dissociation to H{sub 2}CO+C{sub 2}H{sub 4} is the major channel in the title reaction. Three distinct dissociation paths with branching ratios 0.923:0.058:0.019 are responsible for the three features observed in the distribution of kinetic energy released in the channel H{sub 2}CO+C{sub 2}H{sub 4}. The observation of H{sub 2} and H atoms, {approx}1% in branching, indicates that products H{sub 2}CO and C{sub 2}H{sub 4} spontaneously decompose to only a small extent. Most HCO, C{sub 2}H{sub 3}, and C{sub 2}H{sub 2} ions originate from dissociative photoionization of products H{sub 2}CO and C{sub 2}H{sub 4}. Except atomic H and H{sub 2}, the photoproducts have large angular anisotropies, {beta}{>=}-0.8, which reflects rapid dissociation of oxetane following optical excitation at 193.3 nm. The mechanisms of dissociation of oxetane are addressed. Our results confirm the quantum-chemical calculations of Palmer et al. and provide profound insight into the Paterno-Buchi reaction.

  14. Ginsenoside-Rg{sub 1} induces angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a

    SciTech Connect (OSTI)

    Kwok, Hoi-Hin; Chan, Lai-Sheung; Poon, Po-Ying; Yue, Patrick Ying-Kit; Wong, Ricky Ngok-Shun

    2015-09-15

    Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. Ginsenoside-Rg{sub 1} (Rg{sub 1}), one of the most abundant active components of ginseng, has been demonstrated as an angiogenesis-stimulating compound in different models. There is increasing evidence implicating microRNAs (miRNAs), a group of non-coding RNAs, as important regulators of angiogenesis, but the role of microRNAs in Rg{sub 1}-induced angiogenesis has not been fully explored. In this report, we found that stimulating endothelial cells with Rg{sub 1} could reduce miR-23a expression. In silico experiments predicted hepatocyte growth factor receptor (MET), a well-established mediator of angiogenesis, as the target of miR-23a. Transfection of the miR-23a precursor or inhibitor oligonucleotides validated the inverse relationship of miR-23a and MET expression. Luciferase reporter assays further confirmed the interaction between miR-23a and the MET mRNA 3′-UTR. Intriguingly, ginsenoside-Rg{sub 1} was found to increase MET protein expression in a time-dependent manner. We further demonstrated that ginsenoside-Rg{sub 1}-induced angiogenic activities were indeed mediated through the down-regulation of miR-23a and subsequent up-regulation of MET protein expression, as confirmed by gain- and loss-of-function angiogenic experiments. In summary, our results demonstrated that ginsenoside-Rg{sub 1} could induce angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a. This study has broadened our understanding of the non-genomic effects of ginsenoside-Rg{sub 1,} and provided molecular evidence that warrant further development of natural compound as novel angiogenesis-promoting therapy. - Highlights: • Therapeutic angiogenesis has been implicated in ischemic diseases and wound healing. • Ginsenoside-Rg{sub 1} (Rg{sub 1}) has been demonstrated as an angiogenesis-stimulating compound. • We found that Rg{sub 1} induces angiogenesis by

  15. Analysis of the hydraulic data from the MI fracture zone at the Grimsel Rock Laboratory, Switzerland

    SciTech Connect (OSTI)

    Davey, A.; Karasaki, K.; Long, J.C.S.; Landsfeld, M.; Mensch, A.; Martel, S.J.

    1989-10-01

    One of the major problems in analyzing flow and transport in fractured rock is that the flow may be largely confined to a poorly connected network of fractures. In order to overcome some of this problem, Lawrence Berkeley Laboratory (LBL) has been developing a new type of fracture hydrology model called an equivalent discontinuum model. In this model the authors represent the discontinuous nature of the problem through flow on a partially filled lattice. A key component in constructing an equivalent discontinuum model from this lattice is removing some of the conductive elements such that the system is partially connected in the same manner as the fracture network. This is done through a statistical inverse technique called simulated annealing. The fracture network model is annealed by continually modifying a base model, or template such that the modified systems behave more and more like the observed system. In order to see how the simulated annealing algorithm works, the authors have developed a series of synthetic real cases. In these cases, the real system is completely known so that the results of annealing to steady state data can be evaluated absolutely. The effect of the starting configuration has been studied by varying the percent of conducting elements in the initial configuration. Results have shown that the final configurations converge to about the same percentage of conducting elements. An example using Nagra field data from the Migration Experiment (MI) at Grimsel Rock Laboratory in Switzerland is also analyzed. 24 refs., 33 figs., 3 tabs.

  16. EA-1906: Operations, Consolidation, and Upgrades at the Office of Secure Transportation Western Command Site, Albuquerque, NM

    Office of Energy Efficiency and Renewable Energy (EERE)

    This EA evaluates environmental impacts associated with the siting and construction of several proposed buildings, including a new vehicle maintenance facility and mobile equipment maintenance building (and their support structures) at the Western Command Site, Albuquerque, NM.

  17. Multilayer X-ray mirrors for the (4.4-5)-nm carbon-window spectral region

    SciTech Connect (OSTI)

    Andreev, S. S.; Barysheva, M. M.; Vainer, Yu. A.; Gaikovich, P. K.; Pariev, D. E. Pestov, A. E.; Salashchenko, N. N.; Chkhalo, N. I.

    2013-05-15

    Cr/C-based multilayer X-ray mirrors intended for the reflection of X-ray radiation in the 'carbon-window' spectral region ({lambda} = 4.4-5 nm) are fabricated and studied. The structures are formed by magnetron sputtering at different deposition parameters. Under normal incidence, record reflection coefficients up to 15% are reached. The structural parameters of the mirrors are investigated by reflectometry at wavelengths of 0.154 and 4.47 nm.

  18. FINAL REPORT INTEGRATED DM1200 MELTER TESTING USING AZ 102 AND C 106/AY-102 HLW SIMULANTS: HLW SIMULANT VERIFICATION VSL-05R5800-1 REV 0 6/27/05

    SciTech Connect (OSTI)

    KRUGER AA; MATLACK KS; GONG W; BARDAKCI T; D'ANGELO NA; BRANDYS M; KOT WK; PEGG IL

    2011-12-29

    The principal objectives of the DM1200 melter tests were to determine the effects of feed rheology, feed solid content, and bubbler configuration on glass production rate and off-gas system performance while processing the HLW AZ-101 and C-106/AY-102 feed compositions; characterize melter off-gas emissions; characterize the performance of the prototypical off-gas system components, as well as their integrated performance; characterize the feed, glass product, and off-gas effluents; and perform pre- and post test inspections of system components. The specific objectives (including test success criteria) of this testing, along with how each objective was met, are outlined in a table. The data provided in this Final Report address the impacts of HLW melter feed rheology on melter throughput and validation of the simulated HLW melter feeds. The primary purpose of this testing is to further validate/verify the HLW melter simulants that have been used for previous melter testing and to support their continued use in developing melter and off-gas related processing information for the Project. The primary simulant property in question is rheology. Simulants and melter feeds used in all previous melter tests were produced by direct addition of chemicals; these feed tend to be less viscous than rheological the upper-bound feeds made from actual wastes. Data provided here compare melter processing for the melter feed used in all previous DM100 and DM1200 tests (nominal melter feed) with feed adjusted by the feed vendor (NOAH Technologies) to be more viscous, thereby simulating more closely the upperbounding feed produced from actual waste. This report provides results of tests that are described in the Test Plan for this work. The Test Plan is responsive to one of several test objectives covered in the WTP Test Specification for this work; consequently, only part of the scope described in the Test Specification was addressed in this particular Test Plan. For the purpose of

  19. Executive summary of major NuMI lessons learned: a review of relevant meetings of Fermilab's DUSEL Beamline Working Group

    SciTech Connect (OSTI)

    Andrews, Mike; Appel, Jeffrey A.; Bogert, Dixon; Childress, Sam; Cossairt, Don; Griffing, William; Grossman, Nancy; Harding, David; Hylen, Jim; Kuchler, Vic; Laughton, Chris; /Fermilab /Argonne /Brookhaven /LBL, Berkeley

    2009-05-01

    We have gained tremendous experience with the NuMI Project on what was a new level of neutrino beams from a high power proton source. We expect to build on that experience for any new long baseline neutrino beam. In particular, we have learned about some things which have worked well and/or where the experience is fairly directly applicable to the next project (e.g., similar civil construction issues including: tunneling, service buildings, outfitting, and potential claims/legal issues). Some things might be done very differently (e.g., decay pipe, windows, target, beam dump, and precision of power supply control/monitoring). The NuMI experience does lead to identification of critical items for any future such project, and what issues it will be important to address. The DUSEL Beamline Working Group established at Fermilab has been meeting weekly to collect and discuss information from that NuMI experience. This document attempts to assemble much of that information in one place. In this Executive Summary, we group relevant discussion of some of the major issues and lessons learned under seven categories: (1) Differences Between the NuMI Project and Any Next Project; (2) The Process of Starting Up the Project; (3) Decision and Review Processes; (4) ES&H: Environment, Safety, and Health; (5) Local Community Buy-In; (6) Transition from Project Status to Operation; and (7) Some Lessons on Technical Elements. We concentrate here on internal project management issues, including technical areas that require special attention. We cannot ignore, however, two major external management problems that plagued the NuMI project. The first problem was the top-down imposition of an unrealistic combination of scope, cost, and schedule. This situation was partially corrected by a rebaselining. However, the full, desirable scope was never achievable. The second problem was a crippling shortage of resources. Critical early design work could not be done in a timely fashion, leading to

  20. Stress-induced piezoelectric field in GaN-based 450-nm light-emitting diodes

    SciTech Connect (OSTI)

    Tawfik, Wael Z.; Hyeon, Gil Yong; Lee, June Key

    2014-10-28

    We investigated the influence of the built-in piezoelectric field induced by compressive stress on the characteristics of GaN-based 450-nm light-emitting diodes (LEDs) prepared on sapphire substrates of different thicknesses. As the sapphire substrate thickness was reduced, the compressive stress in the GaN layer was released, resulting in wafer bowing. The wafer bowing-induced mechanical stress altered the piezoelectric field, which in turn reduced the quantum confined Stark effect in the InGaN/GaN active region of the LED. The flat-band voltage was estimated by measuring the applied bias voltage that induced a 180° phase shift in the electro-reflectance (ER) spectrum. The piezoelectric field estimated by the ER spectra changed by ∼110 kV/cm. The electroluminescence spectral peak wavelength was blue-shifted, and the internal quantum efficiency was improved by about 22% at a high injection current of 100 mA. The LED on the 60-μm-thick sapphire substrate exhibited the highest light output power of ∼59 mW at an injection current of 100 mA, with the operating voltage unchanged.

  1. Multiplexed Oversampling Digitizer in 65 nm CMOS for Column-Parallel CCD Readout

    SciTech Connect (OSTI)

    Grace, Carl; Walder, Jean-Pierre; von der Lippe, Henrik

    2012-04-10

    A digitizer designed to read out column-parallel charge-coupled devices (CCDs) used for high-speed X-ray imaging is presented. The digitizer is included as part of the High-Speed Image Preprocessor with Oversampling (HIPPO) integrated circuit. The digitizer module comprises a multiplexed, oversampling, 12-bit, 80 MS/s pipelined Analog-to-Digital Converter (ADC) and a bank of four fast-settling sample-and-hold amplifiers to instrument four analog channels. The ADC multiplexes and oversamples to reduce its area to allow integration that is pitch-matched to the columns of the CCD. Novel design techniques are used to enable oversampling and multiplexing with a reduced power penalty. The ADC exhibits 188 ?V-rms noise which is less than 1 LSB at a 12-bit level. The prototype is implemented in a commercially available 65 nm CMOS process. The digitizer will lead to a proof-of-principle 2D 10 Gigapixel/s X-ray detector.

  2. Optical emission from a small scale model electric arc furnace in 250-600 nm region

    SciTech Connect (OSTI)

    Maekinen, A.; Tikkala, H.; Aksela, H.; Niskanen, J.

    2013-04-15

    Optical emission spectroscopy has been for long proposed for monitoring and studying industrial steel making processes. Whereas the radiative decay of thermal excitations is always taking place in high temperatures needed in steel production, one of the most promising environment for such studies are electric arc furnaces, creating plasma in excited electronic states that relax with intense characteristic emission in the optical regime. Unfortunately, large industrial scale electric arc furnaces also present a challenging environment for optical emission studies and application of the method is not straightforward. To study the usability of optical emission spectroscopy in real electric arc furnaces, we have developed a laboratory scale DC electric arc furnace presented in this paper. With the setup, optical emission spectra of Fe, Cr, Cr{sub 2}O{sub 3}, Ni, SiO{sub 2}, Al{sub 2}O{sub 3}, CaO, and MgO were recorded in the wavelength range 250-600 nm and the results were analyzed with the help of reference data. The work demonstrates that using characteristic optical emission, obtaining in situ chemical information from oscillating plasma of electric arc furnaces is indeed possible. In spite of complications, the method could possibly be applied to industrial scale steel making process in order to improve its efficiency.

  3. Nonlinear optical properties of bulk cuprous oxide using single beam Z-scan at 790?nm

    SciTech Connect (OSTI)

    Serna, J.; Rueda, E.; Garca, H.

    2014-11-10

    The two-photon absorption (TPA) coefficient ? and the nonlinear index of refraction n{sub 2} for bulk cuprous oxide (Cu{sub 2}O) direct gap semiconductor single crystal have been measured by using a balance-detection Z-scan single beam technique, with an excellent signal to noise ratio. Both coefficients were measured at 790?nm using a 65 fs laser pulse at a repetition rate of 90.9?MHz, generated by a Ti:Sapphire laser oscillator. The experimental values for ? were explained by using a model that includes allowed-allowed, forbidden-allowed, and forbidden-forbidden transitions. It was found that the forbidden-forbidden transition is the dominant mechanism, which is consistent with the band structure of Cu{sub 2}O. The low value for ? found in bulk, as compared with respect to thin film, is explained in terms of the structural change in thin films that result in opposite parities of the conduction and valence band. The n{sub 2} is also theoretically calculated by using the TPA dispersion curve and the Kramers-Kronig relations for nonlinear optics.

  4. Detonation wave profiles measured in plastic bonded explosives using 1550 nm photon doppler velocimetry (PDV)

    SciTech Connect (OSTI)

    Gustavsen, Richard L; Bartram, Brian D; Sanchez, Nathaniel J

    2009-01-01

    We present detonation wave profiles measured in two TATB based explosives and two HMX based explosives. Profiles were measured at the interface of the explosive and a Lithium-Fluoride (LiF) window using 1550 nm Photon Doppler Velocimetry (PDV). Planar detonations were produced by impacting the explosive with a projectile launched in a gas-gun. The impact state was varied to produce varied distance to detonation, and therefore varied support of the Taylor wave following the Chapman-Jouget (CJ) or sonic state. Profiles from experiments with different support should be the same between the Von-Neumann (VN) spike and CJ state and different thereafter. Comparison of profiles with differing support, therefore, allows us to estimate reaction zone lengths. For the TATB based explosive, a reaction zone length of {approx} 3.9 mm, 500 ns was measured in EDC-35, and a reaction zone length of {approx} 6.3 mm, 800 ns was measured in PBX 9502 pre-cooled to -55 C. The respective VN spike state was 2.25 {+-} 0.05 km/s in EDC-35 and 2.4 {+-} 0.1 km/s in the cooled PBX 9502. We do not believe we have resolved either the VN spike state (> 2.6 km/s) nor the reaction zone length (<< 50 ns) in the HMX based explosives.

  5. Spectral irradiance model for tungsten halogen lamps in 340-850 nm wavelength range

    SciTech Connect (OSTI)

    Ojanen, Maija; Kaerhae, Petri; Ikonen, Erkki

    2010-02-10

    We have developed a physical model for the spectral irradiance of 1 kW tungsten halogen incandescent lamps for the wavelength range 340-850 nm. The model consists of the Planck's radiation law, published values for the emissivity of tungsten, and a residual spectral correction function taking into account unknown factors of the lamp. The correction function was determined by measuring the spectra of a 1000 W, quartz-halogen, tungsten coiled filament (FEL) lamp at different temperatures. The new model was tested with lamps of types FEL and 1000 W, 120 V quartz halogen (DXW). Comparisons with measurements of two national standards laboratories indicate that the model can account for the spectral irradiance values of lamps with an agreement better than 1% throughout the spectral region studied. We further demonstrate that the spectral irradiance of a lamp can be predicted with an expanded uncertainty of 2.6% if the color temperature and illuminance values for the lamp are known with expanded uncertainties of 20 K and 2%, respectively. In addition, it is suggested that the spectral irradiance may be derived from resistance measurements of the filament with lamp on and off.

  6. NM WAIDS: A PRODUCED WATER QUALITY AND INFRASTRUCTURE GIS DATABASE FOR NEW MEXICO OIL PRODUCERS

    SciTech Connect (OSTI)

    Martha Cather; Robert Lee; Ibrahim Gundiler; Andrew Sung; Naomi Davidson; Ajeet Kumar Reddy; Mingzhen Wei

    2003-04-01

    The New Mexico Water and Infrastructure Data System (NM WAIDS) seeks to alleviate a number of produced water-related issues in southeast New Mexico. The project calls for the design and implementation of a Geographical Information System (GIS) and integral tools that will provide operators and regulators with necessary data and useful information to help them make management and regulatory decisions. The major components of this system are: (1) databases on produced water quality, cultural and groundwater data, oil pipeline and infrastructure data, and corrosion information, (2) a web site capable of displaying produced water and infrastructure data in a GIS or accessing some of the data by text-based queries, (3) a fuzzy logic-based, site risk assessment tool that can be used to assess the seriousness of a spill of produced water, and (4) a corrosion management toolkit that will provide operators with data and information on produced waters that will aid them in deciding how to address corrosion issues. The various parts of NM WAIDS will be integrated into a website with a user-friendly interface that will provide access to previously difficult-to-obtain data and information. Primary attention during the first six months of this project has been focused on creating the water quality databases for produced water and surface water, along with collection of corrosion information and building parts of the corrosion toolkit. Work on the project to date includes: (1) Creation of a water quality database for produced water analyses. The database was compiled from a variety of sources and currently has over 4000 entries for southeast New Mexico. (2) Creation of a web-based data entry system for the water quality database. This system allows a user to view, enter, or edit data from a web page rather than having to directly access the database. (3) Creation of a semi-automated data capturing system for use with standard water quality analysis forms. This system improves the

  7. NM WAIDS: A PRODUCED WATER QUALITY AND INFRASTRUCTURE GIS DATABASE FOR NEW MEXICO OIL PRODUCERS

    SciTech Connect (OSTI)

    Martha Cather; Robert Lee; Ibrahim Gundiler; Andrew Sung

    2003-09-24

    The New Mexico Water and Infrastructure Data System (NM WAIDS) seeks to alleviate a number of produced water-related issues in southeast New Mexico. The project calls for the design and implementation of a Geographical Information System (GIS) and integral tools that will provide operators and regulators with necessary data and useful information to help them make management and regulatory decisions. The major components of this system are: (1) Databases on produced water quality, cultural and groundwater data, oil pipeline and infrastructure data, and corrosion information. (2) A web site capable of displaying produced water and infrastructure data in a GIS or accessing some of the data by text-based queries. (3) A fuzzy logic-based, site risk assessment tool that can be used to assess the seriousness of a spill of produced water. (4) A corrosion management toolkit that will provide operators with data and information on produced waters that will aid them in deciding how to address corrosion issues. The various parts of NM WAIDS will be integrated into a website with a user-friendly interface that will provide access to previously difficult-to-obtain data and information. Primary attention during the first six months of this project was focused on creating the water quality databases for produced water and surface water, along with collecting of corrosion information and building parts of the corrosion toolkit. Work on the project to date includes: (1) Creation of a water quality database for produced water analyses. The database was compiled from a variety of sources and currently has over 7000 entries for New Mexico. (2) Creation of a web-based data entry system for the water quality database. This system allows a user to view, enter, or edit data from a web page rather than having to directly access the database. (3) Creation of a semi-automated data capturing system for use with standard water quality analysis forms. This system improves the accuracy and speed

  8. Development of process parameters for 22 nm PMOS using 2-D analytical modeling

    SciTech Connect (OSTI)

    Maheran, A. H. Afifah; Menon, P. S.; Shaari, S.; Ahmad, I.; Faizah, Z. A. Noor

    2015-04-24

    The complementary metal-oxide-semiconductor field effect transistor (CMOSFET) has become major challenge to scaling and integration. Innovation in transistor structures and integration of novel materials are necessary to sustain this performance trend. CMOS variability in the scaling technology becoming very important concern due to limitation of process control; over statistically variability related to the fundamental discreteness and materials. Minimizing the transistor variation through technology optimization and ensuring robust product functionality and performance is the major issue.In this article, the continuation study on process parameters variations is extended and delivered thoroughly in order to achieve a minimum leakage current (I{sub LEAK}) on PMOS planar transistor at 22?nm gate length. Several device parameters are varies significantly using Taguchi method to predict the optimum combination of process parameters fabrication. A combination of high permittivity material (high-k) and metal gate are utilized accordingly as gate structure where the materials include titanium dioxide (TiO{sub 2}) and tungsten silicide (WSi{sub x}). Then the L9 of the Taguchi Orthogonal array is used to analyze the device simulation where the results of signal-to-noise ratio (SNR) of Smaller-the-Better (STB) scheme are studied through the percentage influences of the process parameters. This is to achieve a minimum I{sub LEAK} where the maximum predicted I{sub LEAK} value by International Technology Roadmap for Semiconductors (ITRS) 2011 is said to should not above 100 nA/m. Final results shows that the compensation implantation dose acts as the dominant factor with 68.49% contribution in lowering the devices leakage current. The absolute process parameters combination results in I{sub LEAK} mean value of 3.96821 nA/m where is far lower than the predicted value.

  9. Use of a dynamic simulation model to understand nitrogen cycling in the middle Rio Grande, NM.

    SciTech Connect (OSTI)

    Meixner, Tom; Tidwell, Vincent Carroll; Oelsner, Gretchen; Brooks, Paul; Roach, Jesse D.

    2008-08-01

    Water quality often limits the potential uses of scarce water resources in semiarid and arid regions. To best manage water quality one must understand the sources and sinks of both solutes and water to the river system. Nutrient concentration patterns can identify source and sink locations, but cannot always determine biotic processes that affect nutrient concentrations. Modeling tools can provide insight into these large-scale processes. To address questions about large-scale nitrogen removal in the Middle Rio Grande, NM, we created a system dynamics nitrate model using an existing integrated surface water--groundwater model of the region to evaluate our conceptual models of uptake and denitrification as potential nitrate removal mechanisms. We modeled denitrification in groundwater as a first-order process dependent only on concentration and used a 5% denitrification rate. Uptake was assumed to be proportional to transpiration and was modeled as a percentage of the evapotranspiration calculated within the model multiplied by the nitrate concentration in the water being transpired. We modeled riparian uptake as 90% and agricultural uptake as 50% of the respective evapotranspiration rates. Using these removal rates, our model results suggest that riparian uptake, agricultural uptake and denitrification in groundwater are all needed to produce the observed nitrate concentrations in the groundwater, conveyance channels, and river as well as the seasonal concentration patterns. The model results indicate that a total of 497 metric tons of nitrate-N are removed from the Middle Rio Grande annually. Where river nitrate concentrations are low and there are no large nitrate sources, nitrate behaves nearly conservatively and riparian and agricultural uptake are the most important removal mechanisms. Downstream of a large wastewater nitrate source, denitrification and agricultural uptake were responsible for approximately 90% of the nitrogen removal.

  10. Understanding the anomalous dispersion of doubly-ionized carbon plasmas near 47 nm

    SciTech Connect (OSTI)

    Nilsen, J; Castor, J I; Iglesias, C A; Cheng, K T; Dunn, J; Johnson, W R; Filevich, J; Purvis, M A; Grava, J; Rocca, J J

    2008-04-15

    Over the last several years we have predicted and observed plasmas with an index of refraction greater than one in the soft X-ray regime. These plasmas are usually a few times ionized and have ranged from low-Z carbon plasmas to mid-Z tin plasmas. Our main calculational tool has been the average atom code. We have recently observed C{sup 2+} plasmas with an index of refraction greater than one at a wavelength of 46.9 nm (26.44 eV). In this paper we compare the average atom method, AVATOMKG, against two more detailed methods, OPAL and CAK, for calculating the index of refraction for the carbon plasmas and discuss the different approximations used. We present experimental measurements of carbon plasmas that display this anomalous dispersion phenomenon. It is shown that the average atom calculation is a good approximation when the strongest lines dominate the dispersion. However, when weaker lines make a significant contribution, the more detailed calculations such as OPAL and CAK are essential. During the next decade X-ray free electron lasers and other X-ray sources will be available to probe a wider variety of plasmas at higher densities and shorter wavelengths so understanding the index of refraction in plasmas will be even more essential. With the advent of tunable X-ray lasers the frequency dependent interferometer measurements of the index of refraction may enable us to determine the absorption coefficients and line-shapes and make detailed comparisons against our atomic physics codes.

  11. Direct Probes of 4 nm Diameter Gold Nanoparticles Interacting with Supported Lipid Bylayers

    SciTech Connect (OSTI)

    Troiano, Julianne; Olenick, Laura L.; Kuech, Thomas R.; Melby, Eric S.; Hu, Dehong; Lohse, Samuel E.; Mensch, Arielle C.; Dogangun, Merve; Vartanian, Arlane M.; Torelli, Marco; Ehimiaghe, Eseohi; Walter, Stephanie R.; Fu, Li; Anderton, Christopher R.; Zhu, Zihua; Wang, Hongfei; Orr, Galya; Murphy, Catherine; Hamers, Robert J.; Pedersen, Joel A.; Geiger, Franz M.

    2015-01-08

    Interfacial charge densities and potentials are determined for silica-supported phospholipid bilayers formed from lipids having zwitterionic, negatively charged, and positively charged headgroups. Quartz crystal microbalance with dissipation (QCM-D), fluorescence recovery after photobleaching (FRAP), and atomic force microscopy demonstrate the presence of well-formed supported lipid bilayers, which, as probed by vibrational sum frequency generation (SFG), undergo negligible structural changes along their alkyl chains when NaCl concentration is raised from 0.001 to 0.1 M. From second harmonic generation (SHG) measurements we estimate that each zwitterionic headgroup of the bilayer formed from pure DOPC is associated with an apparent charge of -0.028(+0.008/-0.007)×10-¹⁹C, corresponding to 1.8 ± 0.5 % of an elementary negative charge. Moreover, we show that a supported lipid bilayer carrying an apparent negative interfacial potential may interact with not just positively charged 4-nm diameter gold nanoparticles but also negatively charged gold nanoparticles. In this latter case, charge-charge repulsion does not appear to inhibit particle-bilayer interactions and is likely overcome by multivalent interactions that are estimated to involve 3-5 hydrogen-bond equivalents. FRAP, QCM-D, and SFG measurements indicate that the bilayers remain intact under the conditions of the experiments. SHG charge screening experiments are consistent with an apparent zero net charge density associated with the positively charged gold nanoparticles when they are attached to a supported lipid bilayer carrying an apparent negative potential. The results presented here serve to benchmark experimental and computational studies of the nano-bio interface.

  12. Remediation of a Classified Waste Landfill at Sandia National Laboratories, NM

    SciTech Connect (OSTI)

    Ward, D.C.

    1998-10-20

    The Sandia National Laboratory es/New Mexico (SNLiNM) Environmental Restoration Project is currently excavating the Classified Waste Landfill in Technical Area II (TA-H), which consists of disposal pits and trenches with discrete disposal cells. TA-11 is a secure, controlled assess, research facility managed by SNIJNM for the US Department of Energy (DOE). The 45-acre facility was established in 1948 for the assembly and maintenance of nuclear weapons. The assembly of weapons was discontinued in 1954. Since that time, TA-11 has been used primarily for explosive research and testing. Beginning is 1984, the DOE Er,vironmental Restoration Program conducted several environmental investigations across TA-11 and SNMNM. These investigations identified sites requiring firther study and possible corrective action. The majority of these sites were grouped into operable units (OUS). The TA-11 OU included 13 sites, one of which is identified as the Classified Waste Landfill (CWLF). The CWLF covers about 2.5 acres and was operated from approximately 1947 through 1987. It was the site for disposal of classified weapon components, s ome of which are potentially explosive, hazardous, ardor radioactively contarninatod. Until about 1958, no records were maintained for material disposed of in the CWLF. Information on the CWLF has been assembled horn interview notes, delivery to reckmation records and other sources. Items disposed of included security containers, hoppers, skids, missiles, wooden boxes, deactivated heat sources, tntium boosters, scintillation cocktails, weapons cases, shells, lasers, radar equipment and accountable mata-ials. Potential contaminants include tritium, thorium, cesium-137, strontium-90, uraniun, plutonium, beryllium, cadmium, lithium, chloroform, toluene, benzene ad other solvents.

  13. Charge transfer fluorescence and 34 nm exciton diffusion length in polymers with electron acceptor end traps

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Zaikowski, Lori; Mauro, Gina; Bird, Matthew; Karten, Brianne; Asaoka, Sadayuki; Wu, Qin; Cook, Andrew R.; Miller, John R.

    2014-12-22

    Photoexcitation of conjugated poly-2,7-(9,9-dihexylfluorene) polyfluorenes with naphthylimide (NI) and anthraquinone (AQ) electron-acceptor end traps produces excitons that form charge transfer states at the end traps. Intramolecular singlet exciton transport to end traps was examined by steady state fluorescence for polyfluorenes of 17 to 127 repeat units in chloroform, dimethylformamide (DMF), tetrahydrofuran (THF), and p-xylene. End traps capture excitons and form charge transfer (CT) states at all polymer lengths and in all solvents. The CT nature of the end-trapped states is confirmed by their fluorescence spectra, solvent and trap group dependence and DFT descriptions. Quantum yields of CT fluorescence are asmore » large as 46%. This strong CT emission is understood in terms of intensity borrowing. Energies of the CT states from onsets of the fluorescence spectra give the depths of the traps which vary with solvent polarity. For NI end traps the trap depths are 0.06 (p-xylene), 0.13 (THF) and 0.19 eV (CHCl3). For AQ, CT fluorescence could be observed only in p-xylene where the trap depth is 0.27 eV. Quantum yields, emission energies, charge transfer energies, solvent reorganization and vibrational energies were calculated. Fluorescence measurements on chains >100 repeat units indicate that end traps capture ~50% of the excitons, and that the exciton diffusion length LD =34 nm, which is much larger than diffusion lengths reported in polymer films or than previously known for diffusion along isolated chains. As a result, the efficiency of exciton capture depends on chain length, but not on trap depth, solvent polarity or which trap group is present.« less

  14. Charge Transfer Fluorescence and 34 nm Exciton Diffusion Length in Polymers with Electron Acceptor End Traps

    SciTech Connect (OSTI)

    Zaikowski, L.; Mauro, G.; Bird, M.; Karten, B.; Asaoka, S.; Wu, Q.; Cook, A. R.; Miller, J.

    2014-12-22

    Photoexcitation of conjugated poly-2,7-(9,9-dihexylfluorene) polyfluorenes with naphthylimide (NI) and anthraquinone (AQ) electron-acceptor end traps produces excitons that form charge transfer states at the end traps. Intramolecular singlet exciton transport to end traps was examined by steady state fluorescence for polyfluorenes of 17 to 127 repeat units in chloroform, dimethylformamide (DMF), tetrahydrofuran (THF), and p-xylene. End traps capture excitons and form charge transfer (CT) states at all polymer lengths and in all solvents. The CT nature of the end-trapped states is confirmed by their fluorescence spectra, solvent and trap group dependence and DFT descriptions. Quantum yields of CT fluorescence are as large as 46%. This strong CT emission is understood in terms of intensity borrowing. Energies of the CT states from onsets of the fluorescence spectra give the depths of the traps which vary with solvent polarity. For NI end traps the trap depths are 0.06 (p-xylene), 0.13 (THF) and 0.19 eV (CHCl3). For AQ, CT fluorescence could be observed only in p-xylene where the trap depth is 0.27 eV. Quantum yields, emission energies, charge transfer energies, solvent reorganization and vibrational energies were calculated. Fluorescence measurements on chains >100 repeat units indicate that end traps capture ~50% of the excitons, and that the exciton diffusion length LD =34 nm, which is much larger than diffusion lengths reported in polymer films or than previously known for diffusion along isolated chains. The efficiency of exciton capture depends on chain length, but not on trap depth, solvent polarity or which trap group is present.

  15. Broadband superluminescent diodes with bell-shaped spectra emitting in the range from 800 to 900 nm

    SciTech Connect (OSTI)

    Andreeva, E V; Il'ichenko, S N; Kostin, Yu O; Lapin, P I; Ladugin, M A; Marmalyuk, A A; Yakubovich, S D

    2013-08-31

    Quantum-well superluminescent diodes (SLD) with extremely thin active (AlGa)As and (InGa)As layers and centre wavelengths about 810, 840, 860 and 880 nm are experimentally studied. Their emission spectrum possesses the shape close to Gaussian, its FWHM being 30 – 60 nm depending on the length of the active channel and the level of pumping. Under cw injection, the output power of light-emitting modules based on such SLDs can amount to 1.0 – 25 mW at the output of a single-mode fibre. It is demonstrated that the operation lifetime of these devices exceeds 30000 hours. Based on the light-emitting modules the prototypes of combined BroadLighter series light sources are implemented having a bell-shaped spectrum with the width up to 100 nm. (optical radiation sources)

  16. Effects of solar ultraviolet photons on mammalian cell DNA. [UVA (320-400 nm):a2

    SciTech Connect (OSTI)

    Peak, M.J.; Peak, J.G.

    1991-01-01

    This document presents information on the possible mechanisms of carcinogenesis caused by UVA (ultraviolet radiation in the 320--400 nm region). Most studies showing the carcinogenic effects of ultraviolet light have concentrated on UVB (280--320 nm). UVA had been considered harmless even though it penetrates biological tissues better than UVB. Recently, it has become apparent that UVA is also capable of causing damage to cellular DNA. This was unexpected because the DNA UV absorption spectrum indicates a negligible probability that photons of wavelengths longer than 320 nm will be directly absorbed. The most common defects induced in DNA by UVB are pyrimidine photoproducts, such as thymidine dimers. UVA photons produce defects resembling those caused by ionizing radiations: single- and double-strand breaks, and DNA-protein crosslinks. This paper also discusses the role of DNA repair mechanisms in UVA-induced defects and the molecular mechanisms of UVA damage induction. 38 refs. (MHB)

  17. Modification of laminar flow ultrafine condensation particle counters for the enhanced detection of 1 nm condensation nuclei

    SciTech Connect (OSTI)

    Kuang, C.; Chen, M.; McMurry, P. H.; Wang, J.

    2011-10-01

    This paper describes simple modifications to thermally diffusive laminar flow ultrafine condensation particle counters (UCPCs) that allow detection of {approx}1 nm condensation nuclei with much higher efficiencies than have been previously reported. These nondestructive modifications were applied to a commercial butanol based UCPC (TSI 3025A) and to a diethylene glycol-based UCPC (UMN DEG-UCPC). Size and charge dependent detection efficiencies using the modified UCPCs (BNL 3025A and BNL DEGUCPC) were measured with high resolution mobility classified aerosols composed of NaCl, W, molecular ion standards of tetraalkyl ammonium bromide, and neutralizer-generated ions. With negatively charged NaCl aerosol, the BNL 3025A and BNL DEGUCPC achieved detection efficiencies of 37% (90x increase over TSI 3025A) at 1.68 nm mobility diameter (1.39 nm geometric diameter) and 23% (8x increase over UMN DEG-UCPC) at 1.19 nm mobility diameter (0.89 nm geometric diameter), respectively. Operating conditions for both UCPCs were identified that allowed negatively charged NaCl and W particles, but not negative ions of exactly the same mobility size, to be efficiently detected. This serendipitous material dependence, which is not fundamentally understood, suggests that vapor condensation might sometimes allow for the discrimination between air 'ions' and charged 'particles.' As a detector in a scanning mobility particle spectrometer (SMPS), a UCPC with this strong material dependence would allow for more accurate measurements of sub-2 nm aerosol size distributions due to the reduced interference from neutralizer-generated ions and atmospheric ions, and provide increased sensitivity for the determination of nucleation rates and initial particle growth rates.

  18. Mitsubishi iMiEV: An Electric Mini-Car in NREL's Advanced Technology Vehicle Fleet (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2011-10-01

    This fact sheet highlights the Mitsubishi iMiEV, an electric mini-car in the advanced technology vehicle fleet at the National Renewable Energy Laboratory (NREL). In support of the U.S. Department of Energy's fast-charging research efforts, NREL engineers are conducting charge and discharge performance testing on the vehicle. NREL's advanced technology vehicle fleet features promising technologies to increase efficiency and reduce emissions without sacrificing safety or comfort. The fleet serves as a technology showcase, helping visitors learn about innovative vehicles that are available today or are in development. Vehicles in the fleet are representative of current, advanced, prototype, and emerging technologies.

  19. Pulsed-N{sub 2} assisted growth of 5-20 nm thick β-W films

    SciTech Connect (OSTI)

    Narasimham, Avyaya J.; Green, Avery; Matyi, Richard J.; Khare, Prasanna; Vo, Tuan; Diebold, Alain; LaBella, Vincent P.

    2015-11-15

    A technique to deposit 5-20 nm thick β-phase W using a 2-second periodic pulse of 1 sccm-N{sub 2} gas on Si(001) and SiN(5 nm)/Si(001) substrates is reported. Resistivity, X-ray photoelectron spectroscopy and X-ray reflectivity were utilized to determine phase, bonding and thickness, respectively. X-ray diffraction patterns were utilized to determine the crystal structure, lattice constant and crystal size using the LeBail method. The flow rate of Nitrogen gas (continuous vs. pulsing) had significant impact upon the crystallinity and formation of β-phase W.

  20. FINAL REPORT START-UP AND COMMISSIONING TESTS ON THE DURAMELTER 1200 HLW PILOT MELTER SYSTEM USING AZ-101 HLW SIMULANTS VSL-01R0100-2 REV 0 1/20/03

    SciTech Connect (OSTI)

    KRUGER AA; MATLACK KS; KOT WK; BRANDYS M; WILSON CN; SCHATZ TR; GONG W; PEGG IL

    2011-12-29

    This document provides the final report on data and results obtained from commissioning tests performed on the one-third scale DuraMelter{trademark} 1200 (DM 1200) HLW Pilot Melter system that has been installed at VSL with an integrated prototypical off-gas treatment system. That system has replaced the DM1000 system that was used for HLW throughput testing during Part BI [1]. Both melters have similar melt surface areas (1.2 m{sup 2}) but the DM1200 is prototypical of the present RPP-WTP HLW melter design whereas the DM1000 was not. These tests were performed under a corresponding RPP-WTP Test Specification and associated Test Plan. This report is a followup to the previously issued Preliminary Data Summary Report. The DM1200 system will be used for testing and confirmation of basic design, operability, flow sheet, and process control assumptions as well as for support of waste form qualification and permitting. This will include data on processing rates, off-gas treatment system performance, recycle stream compositions, as well as process operability and reliability. Consequently, this system is a key component of the overall HLW vitrification development strategy. The results presented in this report are from the initial series of short-duration tests that were conducted to support the start-up and commissioning of this system prior to conducting the main body of development tests that have been planned for this system. These tests were directed primarily at system 'debugging,' operator training, and procedure refinement. The AZ-101 waste simulant and glass composition that was used for previous testing was selected for these tests.

  1. Bose-Einstein condensate in a light-induced vector gauge potential using 1064-nm optical-dipole-trap lasers

    SciTech Connect (OSTI)

    Fu Zhengkun; Wang Pengjun; Chai Shijie; Huang Lianghui; Zhang Jing

    2011-10-15

    Using two crossed 1064-nm optical-dipole-trap lasers to be the Raman beams, an effective vector gauge potential for Bose-Einstein condensed {sup 87}Rb in the F=2 hyperfine ground state is experimentally created. The moderate strength of the Raman coupling still can be achieved when the detuning from atomic resonance is larger than the excited-state fine structure, since rubidium has 15 nm energy-level spitting. The atoms at the far detuning of the Raman coupling are loaded adiabatically into the dressed states by ramping the homogeneous bias magnetic field with different paths and the dressed states with different energies are studied experimentally. The experimental scheme can be easily extended to produce the synthetic magnetic or electric field by means of a spatial or time dependence of the effective vector potential.

  2. Electrical and chemical properties of XeCl*(308 nm) exciplex lamp created by a dielectric barrier discharge

    SciTech Connect (OSTI)

    Baadj, S.; Harrache, Z. Belasri, A.

    2013-12-15

    The aim of this work is to highlight, through numerical modeling, the chemical and the electrical characteristics of xenon chloride mixture in XeCl* (308 nm) excimer lamp created by a dielectric barrier discharge. A temporal model, based on the Xe/Cl{sub 2} mixture chemistry, the circuit and the Boltzmann equations, is constructed. The effects of operating voltage, Cl{sub 2} percentage in the Xe/Cl{sub 2} gas mixture, dielectric capacitance, as well as gas pressure on the 308-nm photon generation, under typical experimental operating conditions, have been investigated and discussed. The importance of charged and excited species, including the major electronic and ionic processes, is also demonstrated. The present calculations show clearly that the model predicts the optimal operating conditions and describes the electrical and chemical properties of the XeCl* exciplex lamp.

  3. Laser diodes with 353 nm wavelength enabled by reduced-dislocation-density AlGaN templates

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Crawford, Mary H.; Allerman, Andrew A.; Armstrong, Andrew M.; Smith, Michael L.; Cross, Karen C.

    2015-10-30

    We fabricated optically pumped and electrically injected ultraviolet (UV) lasers on reduced-threading-dislocation-density (reduced-TDD) AlGaN templates. The overgrowth of sub-micron-wide mesas in the Al0.32Ga0.68N templates enabled a tenfold reduction in TDD, to (2–3) × 108 cm–2. Optical pumping of AlGaN hetero-structures grown on the reduced-TDD templates yielded a low lasing threshold of 34 kW/cm2 at 346 nm. Room-temperature pulsed operation of laser diodes at 353 nm was demonstrated, with a threshold of 22.5 kA/cm2. Furthermore, reduced-TDD templates have been developed across the entire range of AlGaN compositions, presenting a promising approach for extending laser diodes into the deep UV.

  4. Laser diodes with 353 nm wavelength enabled by reduced-dislocation-density AlGaN templates

    SciTech Connect (OSTI)

    Crawford, Mary H.; Allerman, Andrew A.; Armstrong, Andrew M.; Smith, Michael L.; Cross, Karen C.

    2015-10-30

    We fabricated optically pumped and electrically injected ultraviolet (UV) lasers on reduced-threading-dislocation-density (reduced-TDD) AlGaN templates. The overgrowth of sub-micron-wide mesas in the Al0.32Ga0.68N templates enabled a tenfold reduction in TDD, to (2–3) × 108 cm–2. Optical pumping of AlGaN hetero-structures grown on the reduced-TDD templates yielded a low lasing threshold of 34 kW/cm2 at 346 nm. Room-temperature pulsed operation of laser diodes at 353 nm was demonstrated, with a threshold of 22.5 kA/cm2. Furthermore, reduced-TDD templates have been developed across the entire range of AlGaN compositions, presenting a promising approach for extending laser diodes into the deep UV.

  5. Award for Nuclear Chemistry LOS ALAMOS, N.M., Aug. 22, 2016-Los Alamos National Laboratory chemist David

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    scientist honored by ACS for innovative studies August 22, 2016 David L. Clark selected for 2017 Glenn T. Seaborg Award for Nuclear Chemistry LOS ALAMOS, N.M., Aug. 22, 2016-Los Alamos National Laboratory chemist David L. Clark has been selected as the 2017 recipient of the Glenn T. Seaborg Award for Nuclear Chemistry, sponsored by the American Chemical Society Division of Nuclear Chemistry and Technology. "Dave is well-known for his breadth of accomplishment in actinide synthesis,

  6. Sub-5 nm Domains in Ordered Poly(cyclohexylethylene)-block-poly(methyl methacrylate) Block Polymers for Lithography.

    SciTech Connect (OSTI)

    Kennemur, Justin; Yao, Li; Bates, Frank Stephen; Hillmyer, Marc

    2014-01-01

    A series of poly(cyclohexylethylene)-block-poly- (methyl methacrylate) (PCHE PMMA) diblock copolymers with varying molar mass (4.9 kg/mol Mn 30.6 kg/mol) and narrow molar mass distribution were synthesized through a combination of anionic and atom transfer radical polymerization (ATRP) techniques. Heterogeneous catalytic hydrogenation of -(hydroxy)polystyrene (PS-OH) yielded -(hydroxy)poly(cyclohexylethylene) (PCHEOH) with little loss of hydroxyl functionality. PCHE-OH was reacted with -bromoisobutyryl bromide (BiBB) to produce an ATRP macroinitiator used for the polymerization of methyl methacrylate. PCHE PMMA is a glassy, thermally stable material with a large effective segment segment interaction parameter, eff = (144.4 6.2)/T (0.162 0.013), determined by meanfield analysis of order-to-disorder transition temperatures (TODT) measured by dynamic mechanical analysis and differential scanning calorimetry. Ordered lamellar domain pitches (9 D 33 nm) were identified by small-angle X-ray scattering from neat BCPs containing 43 52 vol % PCHE ( f PCHE). Atomic force microscopy was used to show 7.5 nm lamellar features (D = 14.8 nm) which are some of the smallest observed to date. The lowest molar mass sample (Mn = 4.9 kg/mol, f PCHE = 0.46) is characterized by TODT = 173 3 C and sub-5 nm nanodomains, which together with the sacrificial properties of PMMA and the high overall thermal stability place this material at the forefront of high- systems for advanced nanopatterning applications.

  7. Role of excited state photoionization in the 852.1 nm Cs laser pumped by Cs-Ar photoassociation

    SciTech Connect (OSTI)

    Hewitt, J. D.; Houlahan, T. J. Jr.; Eden, J. G.; Gallagher, J. E.; Perram, G. P.; Carroll, D. L.; Palla, A. D.; Verdeyen, J. T.

    2013-03-18

    Photoionization of Cs (6p {sup 2}P{sub 3/2}) atoms during the operation of a Cs D{sub 2} line (852.1 nm: 6p {sup 2}P{sub 3/2}{yields}6s {sup 2}S{sub 1/2}) laser, pumped by free{yields}free transitions of thermal Cs-Ar ground state pairs, has been investigated experimentally and computationally. Photoexcitation of Cs vapor/Ar mixtures through the blue satellite of the D{sub 2} transition (peaking at 836.7 nm) selectively populates the {sup 2}P{sub 3/2} upper laser level by the dissociation of the CsAr excited complex. Comparison of laser output energy data, for instantaneous pump powers up to 3 MW, with the predictions of a numerical model sets an upper bound of 8 Multiplication-Sign 10{sup -26} cm{sup 4} W{sup -1} on the Cs (6p {sup 2}P{sub 3/2}) two photon ionization cross-section at 836.7 nm which corresponds to a single photon cross-section of 2.4 Multiplication-Sign 10{sup -19} cm{sup 2} for a peak pump intensity of 3 MW cm{sup -2}.

  8. Note: Deep ultraviolet Raman spectrograph with the laser excitation line down to 177.3 nm and its application

    SciTech Connect (OSTI)

    Jin, Shaoqing; Fan, Fengtao; Guo, Meiling; Zhang, Ying; Feng, Zhaochi E-mail: canli@dicp.ac.cn; Li, Can E-mail: canli@dicp.ac.cn

    2014-04-15

    Deep UV Raman spectrograph with the laser excitation line down to 177.3 nm was developed in this laboratory. An ellipsoidal mirror and a dispersed-subtractive triple monochromator were used to collect and disperse Raman light, respectively. The triple monochromator was arranged in a triangular configuration with only six mirrors used. 177.3 nm laser excited Raman spectrum with cut-off wavenumber down to 200 cm{sup −1} and spectral resolution of 8.0 cm{sup −1} can be obtained under the condition of high purity N{sub 2} purging. With the C–C σ bond in Teflon selectively excited by the 177.3 nm laser, resonance Raman spectrum of Teflon with good quality was recorded on the home-built instrument and the σ-σ{sup *} transition of C–C bond was studied. The result demonstrates that deep UV Raman spectrograph is powerful for studying the systems with electronic transition located in the deep UV region.

  9. Thickness effect on laser-induced-damage threshold of indium-tin oxide films at 1064 nm

    SciTech Connect (OSTI)

    Wang Haifeng; Huang Zhimeng; Zhang Dayong; Luo Fei; Huang Lixian; Li Yanglong; Luo Yongquan; Wang Weiping; Zhao Xiangjie

    2011-12-01

    Laser-induced-damage characteristics of commercial indium-tin oxide (ITO) films deposited by DC magnetron sputtering deposition on K9 glass substrates as a function of the film thickness have been studied at 1064 nm with a 10 ns laser pulse in the 1-on-1 mode, and the various mechanisms for thickness effect on laser-induced-damage threshold (LIDT) of the film have been discussed in detail. It is observed that laser-damage-resistance of ITO film shows dramatic thickness effect with the LIDT of the 50-nm ITO film 7.6 times as large as the value of 300 nm film, and the effect of depressed carrier density by decreasing the film thickness is demonstrated to be the primary reason. Our experiment findings indicate that searching transparent conductive oxide (TCO) film with low carrier density and high carrier mobility is an efficient technique to improve the laser-damage-resistance of TCO films based on maintaining their well electric conductivity.

  10. Intense {ital J}=0{endash}1 soft-x-ray lasing at 28.5 nm in neonlike chromium

    SciTech Connect (OSTI)

    Praeg, A.R.; Loewenthal, F.; Balmer, J.E.

    1996-11-01

    Intense 3{ital p}-3{ital s}, {ital J}=0{endash}1 soft-x-ray lasing at 28.5 nm in neonlike chromium has been observed experimentally using a compact Nd:glass laser as the driver. 2.4-cm-long polished chromium slab targets were irradiated with up to 100-J/500-ps pulses at the fundamental wavelength of 1.054 {mu}m. The prepulse technique was applied using a defined prepulse 5 ns before the main pulse and with a prepulse-to-main pulse energy ratio of 0.7{percent}. It is demonstrated that a pump energy of {approximately}80 J, corresponding to a pump irradiance of approximately 9 TW/cm{sup 2} is sufficient to observe soft-x-ray lasing at 28.5 nm. At a drive laser energy of {approximately}90 J a gain coefficient of (2.2{plus_minus}0.5) cm{sup {minus}1} was measured. The one-dimensional space-resolved measurements show that the 28.5-nm laser line is emitted from a 60-{mu}m-wide (full width at half maximum) plasma region. {copyright} {ital 1996 The American Physical Society.}

  11. A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Nagarkar-Jaiswal, Sonal; Lee, Pei-Tseng; Campbell, Megan E.; Chen, Kuchuan; Anguiano-Zarate, Stephanie; Cantu Gutierrez, Manuel; Busby, Theodore; Lin, Wen-Wen; He, Yuchun; Schulze, Karen L.; et al

    2015-03-31

    Here, we document a collection of ~7434 MiMIC (Minos Mediated Integration Cassette) insertions of which 2854 are inserted in coding introns. They allowed us to create a library of 400 GFP-tagged genes. We show that 72% of internally tagged proteins are functional, and that more than 90% can be imaged in unfixed tissues. Moreover, the tagged mRNAs can be knocked down by RNAi against GFP (iGFPi), and the tagged proteins can be efficiently knocked down by deGradFP technology. The phenotypes associated with RNA and protein knockdown typically correspond to severe loss of function or null mutant phenotypes. Finally, we demonstratemore » reversible, spatial, and temporal knockdown of tagged proteins in larvae and adult flies. This new strategy and collection of strains allows unprecedented in vivo manipulations in flies for many genes. These strategies will likely extend to vertebrates.« less

  12. A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila

    SciTech Connect (OSTI)

    Nagarkar-Jaiswal, Sonal; Lee, Pei-Tseng; Campbell, Megan E.; Chen, Kuchuan; Anguiano-Zarate, Stephanie; Cantu Gutierrez, Manuel; Busby, Theodore; Lin, Wen-Wen; He, Yuchun; Schulze, Karen L.; Booth, Benjamin W.; Evans-Holm, Martha; Venken, Koen J.T.; Levis, Robert W.; Spradling, Allan C.; Hoskins, Roger A.; Bellen, Hugo J.

    2015-03-31

    Here, we document a collection of ~7434 MiMIC (Minos Mediated Integration Cassette) insertions of which 2854 are inserted in coding introns. They allowed us to create a library of 400 GFP-tagged genes. We show that 72% of internally tagged proteins are functional, and that more than 90% can be imaged in unfixed tissues. Moreover, the tagged mRNAs can be knocked down by RNAi against GFP (iGFPi), and the tagged proteins can be efficiently knocked down by deGradFP technology. The phenotypes associated with RNA and protein knockdown typically correspond to severe loss of function or null mutant phenotypes. Finally, we demonstrate reversible, spatial, and temporal knockdown of tagged proteins in larvae and adult flies. This new strategy and collection of strains allows unprecedented in vivo manipulations in flies for many genes. These strategies will likely extend to vertebrates.

  13. Environmental Impact Statements (EIS) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Disposition July 24, 2012 EIS-0403: Final Programmatic Environmental Impact Statement Solar Energy Development in Six Southwestern States (AZ, CA, CO, NV, NM, and UT) May 31,...

  14. NETL F 451.1/1-1, Categorical Exclusion Designation Form

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    393 Arizona State Univ. Phoenix, AZ Lawrence Livermore National Lab (support FWP) - Livermore, CA Sandia National Lab (support FWP) - Albuquerque, NM and Livermore, CA FESCC...

  15. FINAL REPORT MELTER TESTS WITH AZ-101 HLW SIMULANT USING A DURAMELTER 100 VITRIFICATION SYSTEM VSL-01R10N0-1 REV 1 2/25/02

    SciTech Connect (OSTI)

    KRUGER AA; MATLACK KS; KOT WK; PEGG IL

    2011-12-29

    This report provides data, analyses, and conclusions from a series of tests that were conducted at the Vitreous State Laboratory of The Catholic of America (VSL) to determine the processing rates that are achievable with AZ-101 HLW simulants and corresponding melter feeds on a DuraMelter 100 (DM100) vitrification system. One of the most critical pieces of information in determining the required size of the RPP-WTP HLW melter is the specific glass production rate in terms of the mass of glass that can be produced per unit area of melt surface per unit time. The specific glass production rate together with the waste loading (essentially, the ratio of waste-in to glass-out, which is determined from glass formulation activities) determines the melt area that is needed to achieve a given waste processing rate with due allowance for system availability. Tests conducted during Part B1 (VSL-00R2590-2) on the DM1000 vitrification system installed at the Vitreous State Laboratory of The Catholic University of America showed that, without the use of bubblers, glass production rates with AZ-101 and C-106/AY-102 simulants were significantly lower than the Project design basis rate of 0.4 MT/m{sup 2}/d. Conversely, three-fold increases over the design basis rate were demonstrated with the use of bubblers. Furthermore, an un-bubbled control test using a replica of the melter feed used in cold commissioning tests at West Valley reproduced the rates that were observed with that feed on the WVDP production melter. More recent tests conducted on the DM1200 system, which more closely represents the present RPP-WTP design, are in general agreement with these earlier results. Screening tests conducted on the DM10 system have provided good indications of the larger-scale processing rates with bubblers (for both HL W and LAW feeds) but significantly overestimated the DM1000 un-bubbled rate observed for C-106/AY-102 melter feeds. This behavior is believed to be a consequence of the role of

  16. HIA 2015 DOE Zero Energy Ready Home Case Study: Palo Duro Homes, Via del Cielo, Santa Fe, NM

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Via del Cielo Santa Fe, NM DOE ZERO ENERGY READY HOME(tm) The U.S. Department of Energy invites home builders across the country to meet the extraordinary levels of excellence and quality specified in DOE's Zero Energy Ready Home program (formerly known as Challenge Home). Every DOE Zero Energy Ready Home starts with ENERGY STAR Certified Homes Version 3.0 for an energy-efficient home built on a solid foundation of building science research. Advanced technologies are designed in to give you

  17. The effect of layout topology on single-event transient pulse quenching in a 65 nm bulk CMOS process.

    SciTech Connect (OSTI)

    Ball, D. R.; Ahlbin, Jonathan R.; Gadlage, Matthew J.; Massengill, Lloyd W.; Witulski, A. W.; Reed, R. A.; Vizkelethy, Gyorgy; Bhuva, Bharat L.

    2010-07-01

    Heavy-ion microbeam and broadbeam data are presented for a 65 nm bulk CMOS process showing the existence of pulse quenching at normal and angular incidence for designs where the pMOS transistors are in common n-wells or isolated in separate n-wells. Experimental data and simulations show that pulse quenching is more prevalent in the common n-well design than the separate n-well design, leading to significantly reduced SET pulsewidths and SET cross-section in the common n-well design.

  18. Absolute frequency measurement of the 674-nm {sup 88}Sr{sup +} clock transition using a femtosecond optical frequency comb

    SciTech Connect (OSTI)

    Margolis, H.S.; Huang, G.; Barwood, G.P.; Lea, S.N.; Klein, H.A.; Rowley, W.R.C.; Gill, P.; Windeler, R.S.

    2003-03-01

    The frequency of the 5s {sup 2}S{sub 1/2}-4d {sup 2}D{sub 5/2} electric quadrupole transition at 674 nm in a single, trapped, laser-cooled {sup 88}Sr{sup +} ion has been measured with respect to the Systeme International (SI) second using a femtosecond laser optical frequency comb. The measured frequency of 444 779 044 095.52 kHz, with an estimated standard uncertainty of 0.10 kHz, is more accurate than, and in agreement with, the value previously measured using a conventional frequency chain.

  19. Repression of miR-17-5p with elevated expression of E2F-1 and c-MYC in non-metastatic hepatocellular carcinoma and enhancement of cell growth upon reversing this expression pattern

    SciTech Connect (OSTI)

    El Tayebi, H.M.; Omar, K.; Hegy, S.; El Maghrabi, M.; El Brolosy, M.; Hosny, K.A.; Esmat, G.; Abdelaziz, A.I.

    2013-05-10

    Highlights: The oncogenic miR-17-5p is downregulated in non-metastatic hepatocellular carcinoma patients. E2F-1 and c-MYC transcripts are upregulated in non-metastatic HCC patients. miR-17-5p forced overexpression inhibited E2F-1 and c-MYC expression in HuH-7 cells. miR-17-5p mimicking increased HuH-7 cell growth, proliferation, migration and colony formation. miR-17-5p is responsible for HCC progression among the c-MYC/E2F-1/miR-17-5p triad members. -- Abstract: E2F-1, c-MYC, and miR-17-5p is a triad of two regulatory loops: a negative and a positive loop, where c-MYC induces the expression of E2F-1 that induces the expression of miR-17-5p which in turn reverses the expression of E2F-1 to close the loop. In this study, we investigated this triad for the first time in hepatocellular carcinoma (HCC), where miR-17-5p showed a significant down-regulation in 23 non-metastatic HCC biopsies compared to 10 healthy tissues; however, E2F-1 and c-MYC transcripts were markedly elevated. Forced over-expression of miR-17-5p in HuH-7 cells resulted in enhanced cell proliferation, growth, migration and clonogenicity with concomitant inhibition of E2F-1 and c-MYC transcripts expressions, while antagomirs of miR-17-5p reversed these events. In conclusion, this study revealed a unique pattern of expression for miR-17-5p in non-metastatic HCC patients in contrast to metastatic HCC patients. In addition we show that miR-17-5p is the key player among the triad that tumor growth and spread.

  20. US Mnt(S) AZ Site Consumption

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    on air conditioning keeps average site electricity consumption in the state high relative to other parts of the U.S. CONSUMPTION BY END USE A quarter of the energy consumed in ...

  1. A-Z Index | Jefferson Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... O (top) Occupational Medicine Office of Performance Assurance On-Target Newsletter Operations, Accelerator Operations Orientation, Accelerator Organizational Charts Oxygen ...

  2. A-Z Index | Jefferson Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Planning Briefs Building Information Business ... Data Acquisition System (CODA) Data Analysis Center (DAC) at GW (SAID) ... Group Directions, Location, & Maps Director's ...

  3. Sasabe, AZ Natural Gas Exports to Mexico

    Gasoline and Diesel Fuel Update (EIA)

    Cubic Feet) Natural Gas Pipeline Imports From Mexico (Dollars per Thousand Cubic Feet) Roma, TX Natural Gas Pipeline Imports From Mexico (Dollars per Thousand Cubic Feet) Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec 2016 2.06 2.61 - = No Data Reported; -- = Not Applicable; NA = Not Available; W = Withheld to avoid disclosure of individual company data. Release Date: 08/31/2016 Next Release Date: 09/30/2016 Referring Pages: U.S. Price of

    Natural Gas Pipeline Imports From Mexico

  4. US Mnt(S) AZ Site Consumption

    U.S. Energy Information Administration (EIA) Indexed Site

    (Mnt(S)) STATES INCLUDED: Arizona, Nevada, New Mexico All data from EIA's 2009 Residential Energy Consumption Survey www.eia.govconsumptionresidential Space heating Water ...

  5. Douglas, AZ Natural Gas Exports to Mexico

    Gasoline and Diesel Fuel Update (EIA)

    470 44,836 46,069 53,679 64,072 67,144 1996-2015 Pipeline Prices 4.57 4.28 3.06 4.16 5.14 3.22

  6. Berkeley Lab A-Z Link

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Weather Conditions at LBNL http:www.lbl.govazlinkweather-conditions-at-lbnl http:www.lbl.govazlinkweather-conditions-at-lbnlrespond Mon, 14 Dec 2015 20:20:05 +0000...

  7. Seedless Polyol Synthesis and CO Oxidation Activity of Monodisperse (111) and (100)-Oriented Rhodium Nanocrystals in Sub-10 nm Sizes

    SciTech Connect (OSTI)

    Zhang, Yawen; Grass, Michael E.; Huang, Wenyu; Somorjai, Gabor A.

    2010-03-15

    Monodisperse sub-10 nm (6.5 nm) sized Rh nanocrystals with (111) and (100) surface structures were synthesized by a seedless polyol reduction in ethylene glycol, with poly(vinylpyrrolidone) as a capping ligand. When using [Rh(Ac){sub 2}]{sub 2} as the metal precursor, (111)-oriented Rh nanopolyhedra containing 76% (111)-twined hexagons (in 2D projection) were obtained; whereas, when employing RhCl{sub 3} as the metal precursor in the presence of alkylammonium bromide, such as tetramethylammonium bromide and trimethyl(tetradecyl)ammonium bromide, (100)-oriented Rh nanocubes were obtained with 85% selectivity. The {l_brace}100{r_brace} faces of the Rh nanocrystals are stabilized by chemically adsorbed Br{sup -} ions from alkylammonium bromides, which led to (100)-oriented nanocubes. Monolayer films of the (111)-oriented Rh nanopolyhedra and (100)-oriented Rh nanocubes were deposited on silicon wafers in a Langmuir-Blodgett trough to make model 2D nanoarray catalysts. These nanocatalysts were active for CO oxidation by O{sub 2}, and the turnover frequency was independent of nanoparticle shape, consistent with that previously observed for Rh(111) and Rh(100) single crystals.

  8. A combined Kirkpatrick-Baez mirror and multilayer lens for sub-10 nm x-ray focusing

    SciTech Connect (OSTI)

    Ruhlandt, A.; Krueger, S. P.; Osterhoff, M.; Giewekemeyer, K.; Salditt, T.; Liese, T.; Radisch, V.; Krebs, H. U.

    2012-03-15

    We have used a combined optical system of a high gain elliptic Kirkpatrick-Baez mirror system (KB) and a multilayer Laue lens (MLL) positioned in the focal plane of the KB for hard x-rays nano-focusing. The two-step focusing scheme is based on a high acceptance and high gain elliptical mirror with moderate focal length and a MLL with ultra-short focal length. Importantly, fabrication constraints, i.e. in mirror polishing and bending, as well as MLL deposition can be significantly relaxed, since (a) the mirror focus in the range of 200-500 nm is sufficient, and (b) the number of layers of the MLL can be correspondingly small. First demonstrations of this setup at the coherence beamline of the PETRA III storage ring yield a highly divergent far-field diffraction pattern, from which the autocorrelation function of the near-field intensity distribution was obtained. The results show that the approach is well suited to reach smallest spot sizes in the sub-10nm range at high flux.

  9. Resonances in Coupled <mimi><mi>Kmi>-<mi>ηK> Scattering from Quantum Chromodynamics

    SciTech Connect (OSTI)

    Dudek, Jozef J.; Edwards, Robert G.; Thomas, Christopher E.; Wilson, David J.

    2014-10-01

    Using first-principles calculation within Quantum Chromodynamics, we are able to reproduce the pattern of experimental strange resonances which appear as complex singularities within coupled πK, ηK scattering amplitudes. We make use of numerical computation within the lattice discretized approach to QCD, extracting the energy dependence of scattering amplitudes through their relation- ship to the discrete spectrum of the theory in a finite-volume, which we map out in unprecedented detail.

  10. ZERH Training: Albuquerque, NM

    Broader source: Energy.gov [DOE]

    The DOE Zero Energy Ready Home is a high performance home which is so energy efficient, that a renewable energy system can offset all or most of its annual energy Consumption.US DOE Zero Energy...

  11. Sandia Corporation (Albuquerque, NM)

    DOE Patents [OSTI]

    Ewsuk, Kevin G.; Arguello, Jr., Jose G.

    2006-01-31

    A method of designing a primary geometry, such as for a forming die, to be used in a powder pressing application by using a combination of axisymmetric geometric shapes, transition radii, and transition spaces to simulate the geometry where the shapes can be selected from a predetermined list or menu of axisymmetric shapes and then developing a finite element mesh to represent the geometry. This mesh, along with material properties of the component to be designed and powder, is input to a standard deformation finite element code to evaluate the deformation characteristics of the component being designed. The user can develop the geometry interactively with a computer interface in minutes and execute a complete analysis of the deformation characteristics of the simulated component geometry.

  12. Sandia Corporation (Albuquerque, NM)

    DOE Patents [OSTI]

    Diver, Richard B.

    2010-02-23

    A Theoretical Overlay Photographic (TOP) alignment method uses the overlay of a theoretical projected image of a perfectly aligned concentrator on a photographic image of the concentrator to align the mirror facets of a parabolic trough solar concentrator. The alignment method is practical and straightforward, and inherently aligns the mirror facets to the receiver. When integrated with clinometer measurements for which gravity and mechanical drag effects have been accounted for and which are made in a manner and location consistent with the alignment method, all of the mirrors on a common drive can be aligned and optimized for any concentrator orientation.

  13. A study of muon neutrino disappearance with the MINOS detectors and the NuMI neutrino beam

    SciTech Connect (OSTI)

    Marshall, John Stuart; /Cambridge U.

    2008-06-01

    This thesis presents the results of an analysis of {nu}{sub {mu}} disappearance with the MINOS experiment, which studies the neutrino beam produced by the NuMI facility at Fermi National Accelerator Laboratory. The rates and energy spectra of charged current {nu}{sub {mu}} interactions are measured in two similar detectors, located at distances of 1 km and 735 km along the NuMI beamline. The Near Detector provides accurate measurements of the initial beam composition and energy, while the Far Detector is sensitive to the effects of neutrino oscillations. The analysis uses data collected between May 2005 and March 2007, corresponding to an exposure of 2.5 x 10{sup 20} protons on target. As part of the analysis, sophisticated software was developed to identify muon tracks in the detectors and to reconstruct muon kinematics. Events with reconstructed tracks were then analyzed using a multivariate technique to efficiently isolate a pure sample of charged current {nu}{sub {mu}} events. An extrapolation method was also developed, which produces accurate predictions of the Far Detector neutrino energy spectrum, based on data collected at the Near Detector. Finally, several techniques to improve the sensitivity of an oscillation measurement were implemented, and a full study of the systematic uncertainties was performed. Extrapolating from observations at the Near Detector, 733 {+-} 29 Far Detector events were expected in the absence of oscillations, but only 563 events were observed. This deficit in event rate corresponds to a significance of 4.3 standard deviations. The deficit is energy dependent and clear distortion of the Far Detector energy spectrum is observed. A maximum likelihood analysis, which fully accounts for systematic uncertainties, is used to determine the allowed regions for the oscillation parameters and identifies the best fit values as {Delta}m{sub 32}{sup 2} = 2.29{sub -0.14}{sup +0.14} x 10{sup -3} eV{sup 2} and sin{sup 2} 2{theta}{sub 23} > 0

  14. MI C H I GA N M E M O R I A L P H O E N I X PROJECT

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    M M P P - N P C - I - 4 MI C H I GA N M E M O R I A L P H O E N I X PROJECT THE U N I V E R S I T Y OF MI CHI GAN Facsimile Price $ Ij) Microfilm Price $ y / Avoiloble from the O ffic e of Technical Services Department o f Commerce Washington 25, D. C. LATTICE W A VES, SPIN W AVES A N D NEUTRON SCATTERING By B. N . BROCKHOUSE CHALK RIVER PROJECT A T O M IC ENERGY O F C A N A D A LIMITED A PAPER BASED O N LECTURES PRESENTED AT THE NEUTRON PHYSICS CONFERENCE M A C K IN A C ISLAND, M IC H IG A N JU

  15. Design concepts of monolithic metamorphic vertical-cavity surface-emitting lasers for the 1300–1550 nm spectral range

    SciTech Connect (OSTI)

    Egorov, A. Yu. Karachinsky, L. Ya.; Novikov, I. I.; Babichev, A. V.; Nevedomskiy, V. N.; Bugrov, V. E.

    2015-11-15

    Possible design concepts for long-wavelength vertical-cavity surface-emitting lasers for the 1300–1550 nm spectral range on GaAs substrates are suggested. It is shown that a metamorphic GaAs–InGaAs heterostructure with a thin buffer layer providing rapid transition from the lattice constant of GaAs to that of In{sub x}Ga{sub 1–x}As with an indium fraction of x < 0.3 can be formed by molecular-beam epitaxy. Analysis by transmission electron microscopy demonstrated the effective localization of mismatch dislocations in the thin buffer layer and full suppression of their penetration into the overlying InGaAs metamorphic layer.

  16. Metamorphic distributed Bragg reflectors for the 1440–1600 nm spectral range: Epitaxy, formation, and regrowth of mesa structures

    SciTech Connect (OSTI)

    Egorov, A. Yu. Karachinsky, L. Ya.; Novikov, I. I.; Babichev, A. V.; Berezovskaya, T. N.; Nevedomskiy, V. N.

    2015-10-15

    It is shown that metamorphic In{sub 0.3}Ga{sub 0.7}As/In{sub 0.3}Al{sub 0.7}As distributed Bragg reflectors (DBRs) with a reflection band at 1440–1600 nm and a reflectance of no less than 0.999 can be fabricated by molecular beam epitaxy (MBE) on a GaAs substrate. It is demonstrated that mesa structures formed from metamorphic DBRs on a GaAs substrate can be regrown by MBE and microcavities can be locally formed in two separate epitaxial processes. The results obtained can find wide application in the fabrication of vertical-cavity surface-emitting lasers (VCSELs) with a buried tunnel junction.

  17. Subkilohertz absolute-frequency measurement of the 467-nm electric octupole transition in {sup 171}Yb{sup +}

    SciTech Connect (OSTI)

    Blythe, P.J.; Gill, P.; Webster, S.A.; Margolis, H.S.; Lea, S.N.; Huang, G.; Choi, S.-K.; Rowley, W.R.C.; Windeler, R.S.

    2003-02-01

    The {sup 2}S{sub 1/2}(F=0){yields}{sup 2}F{sub 7/2}(F=3,m{sub F}=0) transition at 467 nm in a single trapped, laser-cooled ion of {sup 171}Yb{sup +} has been measured to be f{sub Yb{sup +}}=642 121 496 771.26(23) kHz using a femtosecond laser frequency comb generator. The measurement is limited by measurement statistics and by the ac Stark shift, both related to the 4.5 kHz linewidth of the probe laser at the time. The systematic shifts of the transition, including ac Stark, second-order Zeeman, quadrupole, and blackbody shifts, have been evaluated.

  18. Ab initio calculations of external-field shifts of the 661-nm quadrupolar clock transition in neutral Ag atoms

    SciTech Connect (OSTI)

    Topcu, Suat; Nasser, Jamil; Daku, Latevi Max Lawson; Fritzsche, Stephan

    2006-04-15

    Frequency shifts of the Ag I 4d{sup 10}5s {sup 2}S{sub 1/2}(F=0,M{sub F}=0) to 4d{sup 9}5s{sup 2} {sup 2}D{sub 5/2}(F{sup '}=2,M{sub F{sup '}}=0) electric-quadrupole transition at 330.6 nm due to external fields are calculated using multiconfigurational self-consistent field methods. As this forbidden transition is free from first order Doppler and Zeeman effects, it is under investigation for the realization of an atomic optical clock. The calculated perturbations are the light shift, the blackbody frequency shift, and the quadratic Zeeman shift. Results show that a total uncertainty of 10{sup -18} could be reach without confining the atoms in a Lamb-Dicke regime in an optical lattice.

  19. Frequency stabilization of a 1083 nm fiber laser to {sup 4}He transition lines with optical heterodyne saturation spectroscopies

    SciTech Connect (OSTI)

    Gong, W.; Peng, X. Li, W.; Guo, H.

    2014-07-15

    Two kinds of optical heterodyne saturation spectroscopies, namely, frequency modulation spectroscopy (FMS) and modulation transfer spectroscopy (MTS), are demonstrated for locking a fiber laser to the transition lines of metastable {sup 4}He atoms around 1083 nm. The servo-loop error signals of FMS and MTS for stabilizing laser frequency are optimized by studying the dependence of the peak-to-peak amplitude and slope on the optical power of pump and probe beams. A comparison of the stabilization performances of FMS/MTS and polarization spectroscopy (PS) is presented, which shows that MTS exhibits relatively superior performance with the least laser frequency fluctuation due to its flat-background dispersive signal, originated from the four-wave mixing process. The Allan deviation of the stabilized laser frequency is 5.4 10{sup ?12}@100 s with MTS for data acquired in 1000 s, which is sufficiently applicable for fields like laser cooling, optical pumping, and optical magnetometry.

  20. Microfluidic molecular assay platform for the detection of miRNAs, mRNAs, proteins, and post-translational modifications at single-cell resolution

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wu, Meiye; Singh, Anup K.

    2014-07-15

    In this study, cell signaling is a dynamic and complex process. A typical signaling pathway may begin with activation of cell surface receptors, leading to activation kinase cascade that culminates in induction of mRNA and non-coding miRNA production in the nucleus, followed by modulation of mRNA expression by miRNAs in the cytosol, and end with production of proteins in response to the signaling pathway. Signaling pathways involve proteins, miRNA, and mRNAs, along with various forms of transient post-translational modifications, and detecting each type of signaling molecule requires categorically different sample preparation methods such as Western blotting for proteins, PCR formore » nucleic acids, and flow cytometry for post-translational modifications. Since we know that cells in populations behave heterogeneously1, especially in the cases of stem cells, cancer, and hematopoiesis, there is need for a new technology that provides capability to detect and quantify multiple categories of signaling molecules in intact single cells to provide a comprehensive view of the cell’s physiological state. In this technical brief, we describe our microfluidic platform with a portfolio of customized molecular assays that can detect nucleic acids, proteins, and post-translational modifications in single intact cells with >95% reduction in reagent requirement in under 8 hours.« less

  1. Microfluidic molecular assay platform for the detection of miRNAs, mRNAs, proteins, and post-translational modifications at single-cell resolution

    SciTech Connect (OSTI)

    Wu, Meiye; Singh, Anup K.

    2014-07-15

    In this study, cell signaling is a dynamic and complex process. A typical signaling pathway may begin with activation of cell surface receptors, leading to activation kinase cascade that culminates in induction of mRNA and non-coding miRNA production in the nucleus, followed by modulation of mRNA expression by miRNAs in the cytosol, and end with production of proteins in response to the signaling pathway. Signaling pathways involve proteins, miRNA, and mRNAs, along with various forms of transient post-translational modifications, and detecting each type of signaling molecule requires categorically different sample preparation methods such as Western blotting for proteins, PCR for nucleic acids, and flow cytometry for post-translational modifications. Since we know that cells in populations behave heterogeneously1, especially in the cases of stem cells, cancer, and hematopoiesis, there is need for a new technology that provides capability to detect and quantify multiple categories of signaling molecules in intact single cells to provide a comprehensive view of the cell’s physiological state. In this technical brief, we describe our microfluidic platform with a portfolio of customized molecular assays that can detect nucleic acids, proteins, and post-translational modifications in single intact cells with >95% reduction in reagent requirement in under 8 hours.

  2. Microfluidic Molecular Assay Platform for the Detection of miRNAs, mRNAs, Proteins, and Posttranslational Modifications at Single-Cell Resolution

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wu, Meiye; Singh, Anup K.

    2014-07-15

    Cell signaling is a dynamic and complex process. A typical signaling pathway may begin with activation of cell surface receptors, leading to activation kinase cascade that culminates in induction of mRNA and non-coding miRNA production in the nucleus, followed by modulation of mRNA expression by miRNAs in the cytosol, and end with production of proteins in response to the signaling pathway. Signaling pathways involve proteins, miRNA, and mRNAs, along with various forms of transient post-translational modifications, and detecting each type of signaling molecule requires categorically different sample preparation methods such as Western blotting for proteins, PCR for nucleic acids, andmoreflow cytometry for post-translational modifications. Since we know that cells in populations behave heterogeneously1, especially in the cases of stem cells, cancer, and hematopoiesis, there is need for a new technology that provides capability to detect and quantify multiple categories of signaling molecules in intact single cells to provide a comprehensive view of the cells physiological state. In this technical brief, we describe our microfluidic platform with a portfolio of customized molecular assays that can detect nucleic acids, proteins, and post-translational modifications in single intact cells with >95% reduction in reagent requirement in under 8 hours.less

  3. Uniform 2 nm gold nanoparticles supported on iron oxides as active catalysts for CO oxidation reaction: Structure-activity relationship

    SciTech Connect (OSTI)

    Guo, Yu; Senanayake, Sanjaya; Gu, Dong; Jin, Zhao; Du, Pei -Pei; Si, Rui; Xu, Wen -Qian; Huang, Yu -Ying; Tao, Jing; Song, Qi -Sheng; Jia, Chun -Jia; Schueth, Ferdi

    2015-01-12

    Uniform Au nanoparticles (~2 nm) with narrow size-distribution (standard deviation: 0.5–0.6 nm) supported on both hydroxylated (Fe_OH) and dehydrated iron oxide (Fe_O) have been prepared by either deposition-precipitation (DP) or colloidal-deposition (CD) methods. Different structural and textural characterizations were applied to the dried, calcined and used gold-iron oxide samples. The transmission electron microscopy (TEM) and high-resolution TEM (HRTEM) described the high homogeneity in the supported Au nanoparticles. The ex-situ and in-situ X-ray absorption fine structure (XAFS) characterization monitored the electronic and short-range local structure of active gold species. The synchrotron-based in-situ X-ray diffraction (XRD), together with the corresponding temperature-programmed reduction by hydrogen (H₂-TPR), indicated a structural evolution of the iron-oxide supports, correlating to their reducibility. An inverse order of catalytic activity between DP (Au/Fe_OH < Au/Fe_O) and CD (Au/Fe_OH > Au/Fe_O) was observed. Effective gold-support interaction results in a high activity for gold nanoparticles, locally generated by the sintering of dispersed Au atoms on the oxide support in the DP synthesis, while a hydroxylated surface favors the reactivity of externally introduced Au nanoparticles on Fe_OH support for the CD approach. This work reveals why differences in the synthetic protocol translate to differences in the catalytic performance of Au/FeOx catalysts with very similar structural characteristics in CO oxidation.

  4. Uniform 2 nm gold nanoparticles supported on iron oxides as active catalysts for CO oxidation reaction: Structure-activity relationship

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Guo, Yu; Senanayake, Sanjaya; Gu, Dong; Jin, Zhao; Du, Pei -Pei; Si, Rui; Xu, Wen -Qian; Huang, Yu -Ying; Tao, Jing; Song, Qi -Sheng; et al

    2015-01-12

    Uniform Au nanoparticles (~2 nm) with narrow size-distribution (standard deviation: 0.5–0.6 nm) supported on both hydroxylated (Fe_OH) and dehydrated iron oxide (Fe_O) have been prepared by either deposition-precipitation (DP) or colloidal-deposition (CD) methods. Different structural and textural characterizations were applied to the dried, calcined and used gold-iron oxide samples. The transmission electron microscopy (TEM) and high-resolution TEM (HRTEM) described the high homogeneity in the supported Au nanoparticles. The ex-situ and in-situ X-ray absorption fine structure (XAFS) characterization monitored the electronic and short-range local structure of active gold species. The synchrotron-based in-situ X-ray diffraction (XRD), together with the corresponding temperature-programmed reductionmore » by hydrogen (H₂-TPR), indicated a structural evolution of the iron-oxide supports, correlating to their reducibility. An inverse order of catalytic activity between DP (Au/Fe_OH < Au/Fe_O) and CD (Au/Fe_OH > Au/Fe_O) was observed. Effective gold-support interaction results in a high activity for gold nanoparticles, locally generated by the sintering of dispersed Au atoms on the oxide support in the DP synthesis, while a hydroxylated surface favors the reactivity of externally introduced Au nanoparticles on Fe_OH support for the CD approach. This work reveals why differences in the synthetic protocol translate to differences in the catalytic performance of Au/FeOx catalysts with very similar structural characteristics in CO oxidation.« less

  5. Viability of Cladosporium herbarum spores under 157 nm laser and vacuum ultraviolet irradiation, low temperature (10 K) and vacuum

    SciTech Connect (OSTI)

    Sarantopoulou, E. Stefi, A.; Kollia, Z.; Palles, D.; Cefalas, A. C.; Petrou, P. S.; Bourkoula, A.; Koukouvinos, G.; Kakabakos, S.; Velentzas, A. D.

    2014-09-14

    Ultraviolet photons can damage microorganisms, which rarely survive prolonged irradiation. In addition to the need for intact DNA, cell viability is directly linked to the functionality of the cell wall and membrane. In this work, Cladosporium herbarum spore monolayers exhibit high viability (7%) when exposed to 157 nm laser irradiation (412 kJm⁻²) or vacuum-ultraviolet irradiation (110–180 nm) under standard pressure and temperature in a nitrogen atmosphere. Spore viability can be determined by atomic-force microscopy, nano-indentation, mass, μ-Raman and attenuated reflectance Fourier-transform far-infrared spectroscopies and DNA electrophoresis. Vacuum ultraviolet photons cause molecular damage to the cell wall, but radiation resistance in spores arises from the activation of a photon-triggered signaling reaction, expressed via the exudation of intracellular substances, which, in combination with the low penetration depth of vacuum-ultraviolet photons, shields DNA from radiation. Resistance to phototoxicity under standard conditions was assessed, as was resistance to additional environmental stresses, including exposure in a vacuum, under different rates of change of pressure during pumping time and low (10 K) temperatures. Vacuum conditions were far more destructive to spores than vacuum-ultraviolet irradiation, and UV-B photons were two orders of magnitude more damaging than vacuum-ultraviolet photons. The viability of irradiated spores was also enhanced at 10 K. This work, in addition to contributing to the photonic control of the viability of microorganisms exposed under extreme conditions, including decontamination of biological warfare agents, outlines the basis for identifying bio-signaling in vivo using physical methodologies.

  6. Method to grow carbon thin films consisting entirely of diamond grains 3-5 nm in size and high-energy grain boundaries

    DOE Patents [OSTI]

    Carlisle, John A.; Auciello, Orlando; Birrell, James

    2006-10-31

    An ultrananocrystalline diamond (UNCD) having an average grain size between 3 and 5 nanometers (nm) with not more than about 8% by volume diamond having an average grain size larger than 10 nm. A method of manufacturing UNCD film is also disclosed in which a vapor of acetylene and hydrogen in an inert gas other than He wherein the volume ratio of acetylene to hydrogen is greater than 0.35 and less than 0.85, with the balance being an inert gas, is subjected to a suitable amount of energy to fragment at least some of the acetylene to form a UNCD film having an average grain size of 3 to 5 nm with not more than about 8% by volume diamond having an average grain size larger than 10 nm.

  7. Multi-step ion beam etching of sub-30 nm magnetic tunnel junctions for reducing leakage and MgO barrier damage

    SciTech Connect (OSTI)

    Chun, Sung-woo; Kim, Daehong; Kwon, Jihun; Kim, Bongho; Choi, Seonjun; Lee, Seung-Beck

    2012-04-01

    We have demonstrated the fabrication of sub 30 nm magnetic tunnel junctions (MTJs) with perpendicular magnetic anisotropy. The multi-step ion beam etching (IBE) process performed for 18 min between 45 deg. and 30 deg. , at 500 V combined ion supply voltage, resulted in a 55 nm tall MTJ with 28 nm diameter. We used a negative tone electron beam resist as the hard mask, which maintained its lateral dimension during the IBE, allowing almost vertical pillar side profiles. The measurement results showed a tunnel magneto-resistance ratio of 13% at 1 k{Omega} junction resistance. With further optimization in IBE energy and multi-step etching process, it will be possible to fabricate perpendicularly oriented MTJs for future sub 30 nm non-volatile magnetic memory applications.

  8. Observation of Electron Neutrino Appearance in the NuMI Beam with the NOvA Experiment

    SciTech Connect (OSTI)

    Niner, Evan David

    2015-01-01

    NOvA is a long-baseline neutrino oscillation experiment that uses two functionally identical detectors separated by 810 kilometers at locations 14 milliradians off-axis from the NuMI muon neutrino beam at Fermilab. At these locations the beam energy peaks at 2 GeV. This baseline is the longest in the world for an accelerator-based neutrino oscillation experiment, which enhances the sensitivity to the neutrino mass ordering. The experiment studies oscillations of the muon neutrino and anti-neutrino beam that is produced. Both detectors completed commissioning in the summer of 2014 and continue to collect data. One of the primary physics goals of the experiment is the measurement of electron neutrino appearance in the muon neutrino beam which yields measurements of the oscillation parameters sin213, δ , and the neutrino mass ordering within the standard model of neutrino oscillations. This thesis presents the analysis of data collected between February 2014 and May 2015, corresponding to 3.52 X 1020 protons-on-target. In this first analysis NOvA recorded 6 electron neutrino candidates, which is a 3.3σ observation of electron neutrino appearance. The T2K experiment performs the same measurement on a baseline of 295 kilometers and has a 1 σ preference for the normal mass ordering over the inverted ordering over the phase space of the CP violating parameter δ, which is also weakly seen in the NOvA result. By the summer of 2016 NOvA will triple its statistics due to increased beam power and a completed detector. If electron neutrinos continue to be observed at the current rate NOvA will be able to establish a mass ordering preference at a similar confidence level to T2K.

  9. Approach to Recover Hydrocarbons from Currently Off-Limit Areas of the Antrim Formation, MI Using Low-Impact Technologies

    SciTech Connect (OSTI)

    James Wood; William Quinlan

    2008-09-30

    The goal of this project was to develop and execute a novel drilling and completion program in the Antrim Shale near the western shoreline of Northern Michigan. The target was the gas in the Lower Antrim Formation (Upper Devonian). Another goal was to see if drilling permits could be obtained from the Michigan DNR that would allow exploitation of reserves currently off-limits to exploration. This project met both of these goals: the DNR (Michigan Department of Natural Resources) issued permits that allow drilling the shallow subsurface for exploration and production. This project obtained drilling permits for the original demonstration well AG-A-MING 4-12 HD (API: 21-009-58153-0000) and AG-A-MING 4-12 HD1 (API: 21-009-58153-0100) as well as for similar Antrim wells in Benzie County, MI, the Colfax 3-28 HD and nearby Colfax 2-28 HD which were substituted for the AG-A-MING well. This project also developed successful techniques and strategies for producing the shallow gas. In addition to the project demonstration well over 20 wells have been drilled to date into the shallow Antrim as a result of this project's findings. Further, fracture stimulation has proven to be a vital step in improving the deliverability of wells to deem them commercial. Our initial plan was very simple; the 'J-well' design. We proposed to drill a vertical or slant well 30.48 meters (100 feet) below the glacial drift, set required casing, then angle back up to tap the resource lying between the base to the drift and the conventional vertical well. The 'J'-well design was tested at Mancelona Township in Antrim County in February of 2007 with the St. Mancelona 2-12 HD 3.

  10. Phase diagram and transformations of iron pentacarbonyl to nm layered hematite and carbon-oxygen polymer under pressure

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ryu, Young Jay; Kim, Minseob; Yoo, Choong -Shik

    2015-10-12

    In this study, we present the phase diagram of Fe(CO)5, consisting of three molecular polymorphs (phase I, II and III) and an extended polymeric phase that can be recovered at ambient condition. The phase diagram indicates a limited stability of Fe(CO)5 within a pressure-temperature dome formed below the liquid- phase II- polymer triple point at 4.2 GPa and 580 K. The limited stability, in turn, signifies the temperature-induced weakening of Fe-CO back bonds, which eventually leads to the dissociation of Fe-CO at the onset of the polymerization of CO. The recovered polymer is a composite of novel nm-lamellar layers ofmore » crystalline hematite Fe2O3 and amorphous carbon-oxygen polymers. These results, therefore, demonstrate the synthesis of carbon-oxygen polymer by compressing Fe(CO)5, which advocates a novel synthetic route to develop atomistic composite materials by compressing organometallic compounds.« less

  11. Towards Next Generation TATB-based Explosives by Understanding Voids and Microstructure from 10 nm to 1 cm

    SciTech Connect (OSTI)

    Willey, T M; Overturf, G

    2009-03-26

    TATB-based explosives have been investigated on length scales spanning several orders of magnitude, from just under 10 nm to larger than 1 cm. This has been accomplished using a combination of ultra-small angle x-ray scattering (USAXS), ultra-small angle neutron scattering (USANS), and x-ray computed tomography (XRCT). USAXS determines distributions the smallest structures including hot-spot voids from hundreds of nanometers to a few microns, USANS extends this range to about 10 microns, and two variants of XRCT cover sizes from microns to centimeters. Several examples are presented for LX-17, a triaminotrinitrobenzene based plastic bonded explosive using Kel-F 800. As an extension of previous USAXS results, in these proceedings, an alternate binder results in a more uniform microstructure for the PBX, useful towards design of next-generation TATB-based explosives. These data are an important step to understanding microstructural mechanisms that affect the mechanical properties of TATB-based explosives, and provide complete a comprehensive characterization of the structure of LX-17 from nanometers to centimeters that can be used as empirical input to computational models of detonation, and in determining the relationship between voids and microstructure to detonation properties.

  12. O({sup 3}P{sub J}) formation and desorption by 157-nm photoirradiation of amorphous solid water

    SciTech Connect (OSTI)

    DeSimone, Alice J.; Orlando, Thomas M.

    2014-03-07

    Photodissociation of amorphous solid water (ASW) deposited on a thinly oxidized copper substrate at 82 K was studied by measuring O({sup 3}P{sub J=2,1,0}) photoproducts detected with resonance-enhanced multiphoton ionization. For each spin-orbit state, the oxygen atom time-of-flight spectrum was measured as a function of H{sub 2}O exposure, which is related to ice thickness, and 157-nm irradiation time. Four Maxwell-Boltzmann distributions with translational temperatures of 10?000 K, 1800 K, 400 K, and 82 K were found to fit the data. The most likely formation mechanisms are molecular elimination following ionization of water and ion-electron recombination, secondary recombination of hydroxyl radicals, and photodissociation of adsorbed hydroxyl radicals. Evidence for O-atom diffusion through bulk ASW was found for H{sub 2}O exposures of at least 5 Langmuir (1 L = 10{sup ?6} Torr?s). The cross sections for O({sup 3}P{sub 2}) depletion were 1.3 10{sup ?19} and 6.5 10{sup ?20} cm{sup 2} for 1 and 5 L, respectively.

  13. Translational and internal energy distributions of methyl and hydroxyl radicals produced by 157 nm photodissociation of amorphous solid methanol

    SciTech Connect (OSTI)

    Hama, Tetsuya; Yokoyama, Masaaki; Yabushita, Akihiro; Kawasaki, Masahiro; Wickramasinghe, Piyumie; Guo Wei; Loock, Hans-Peter; Ashfold, Michael N. R.; Western, Colin M.

    2009-12-14

    Methanol is typically observed within water-rich interstellar ices and is a source of interstellar organic species. Following the 157 nm photoexcitation of solid methanol at 90 K, desorbed CH{sub 3}(v=0) and OH(v=0,1) radicals have been observed in situ, near the solid surface, using resonance-enhanced multiphoton ionization (REMPI) detection methods. Time-of-flight and rotationally resolved REMPI spectra of the desorbed species were measured, and the respective fragment internal energy and kinetic energy distributions were obtained. Photoproduction mechanisms for CH{sub 3} and OH radicals from solid methanol are discussed. The formation of O({sup 1}D and {sup 3}P) atoms and H{sub 2}O was investigated, but the yield of these species was found to be negligible. CH{sub 3} products arising following the photoexcitation of water-methanol mixed ice showed similar kinetic and internal energy distributions to those from neat methanol ice.

  14. Phase diagram and transformations of iron pentacarbonyl to nm layered hematite and carbon-oxygen polymer under pressure

    SciTech Connect (OSTI)

    Ryu, Young Jay; Kim, Minseob; Yoo, Choong -Shik

    2015-10-12

    In this study, we present the phase diagram of Fe(CO)5, consisting of three molecular polymorphs (phase I, II and III) and an extended polymeric phase that can be recovered at ambient condition. The phase diagram indicates a limited stability of Fe(CO)5 within a pressure-temperature dome formed below the liquid- phase II- polymer triple point at 4.2 GPa and 580 K. The limited stability, in turn, signifies the temperature-induced weakening of Fe-CO back bonds, which eventually leads to the dissociation of Fe-CO at the onset of the polymerization of CO. The recovered polymer is a composite of novel nm-lamellar layers of crystalline hematite Fe2O3 and amorphous carbon-oxygen polymers. These results, therefore, demonstrate the synthesis of carbon-oxygen polymer by compressing Fe(CO)5, which advocates a novel synthetic route to develop atomistic composite materials by compressing organometallic compounds.

  15. Experimental investigation of factors limiting slow axis beam quality in 9xx nm high power broad area diode lasers

    SciTech Connect (OSTI)

    Winterfeldt, M. Crump, P.; Wenzel, H.; Erbert, G.; Trnkle, G.

    2014-08-14

    GaAs-based broad-area diode lasers are needed with improved lateral beam parameter product (BPP{sub lat}) at high power. An experimental study of the factors limiting BPP{sub lat} is therefore presented, using extreme double-asymmetric (EDAS) vertical structures emitting at 910?nm. Continuous wave, pulsed and polarization-resolved measurements are presented and compared to thermal simulation. The importance of thermal and packaging-induced effects is determined by comparing junction -up and -down devices. Process factors are clarified by comparing diodes with and without index-guiding trenches. We show that in all cases studied, BPP{sub lat} is limited by a non-thermal BPP ground-level and a thermal BPP, which depends linearly on self-heating. Measurements as a function of pulse width confirm that self-heating rather than bias-level dominates. Diodes without trenches show low BPP ground-level, and a thermal BPP which depends strongly on mounting, due to changes in the temperature profile. The additional lateral guiding in diodes with trenches strongly increases the BPP ground-level, but optically isolates the stripe from the device edges, suppressing the influence of the thermal profile, leading to a BPP-slope that is low and independent of mounting. Trenches are also shown to initiate strain fields that cause parasitic TM-polarized emission with large BPP{sub lat}, whose influence on total BPP{sub lat} remains small, provided the overall polarization purity is >95%.

  16. Sub-10 nm Platinum Nanocrystals with Size and Shape Control: Catalytic Study for Ethylene and Pyrrole Hydrogenation

    SciTech Connect (OSTI)

    Tsung, Chia-Kuang; Kuhn, John N.; Huang, Wenyu; Aliaga, Cesar; Hung, Ling-I; Somorjai, Gabor A.; Yang, Peidong

    2009-03-02

    Platinum nanocubes and nanopolyhedra with tunable size from 5 to 9 nm were synthesized by controlling the reducing rate of metal precursor ions in a one-pot polyol synthesis. A two-stage process is proposed for the simultaneous control of size and shape. In the first stage, the oxidation state of the metal ion precursors determined the nucleation rate and consequently the number of nuclei. The reaction temperature controlled the shape in the second stage by regulation of the growth kinetics. These well-defined nanocrystals were loaded into MCF-17 mesoporous silica for examination of catalytic properties. Pt loadings and dispersions of the supported catalysts were determined by elemental analysis (ICP-MS) and H2 chemisorption isotherms, respectively. Ethylene hydrogenation rates over the Pt nanocrystals were independent of both size and shape and comparable to Pt single crystals. For pyrrole hydrogenation, the nanocubes enhanced ring-opening ability and thus showed a higher selectivity to n-butylamine as compared to nanopolyhedra.

  17. THE EVOLUTION OF SOLAR FLUX FROM 0.1 nm TO 160 {mu}m: QUANTITATIVE ESTIMATES FOR PLANETARY STUDIES

    SciTech Connect (OSTI)

    Claire, Mark W.; Sheets, John; Meadows, Victoria S.; Cohen, Martin; Ribas, Ignasi; Catling, David C.

    2012-09-20

    Understanding changes in the solar flux over geologic time is vital for understanding the evolution of planetary atmospheres because it affects atmospheric escape and chemistry, as well as climate. We describe a numerical parameterization for wavelength-dependent changes to the non-attenuated solar flux appropriate for most times and places in the solar system. We combine data from the Sun and solar analogs to estimate enhanced UV and X-ray fluxes for the young Sun and use standard solar models to estimate changing visible and infrared fluxes. The parameterization, a series of multipliers relative to the modern top of the atmosphere flux at Earth, is valid from 0.1 nm through the infrared, and from 0.6 Gyr through 6.7 Gyr, and is extended from the solar zero-age main sequence to 8.0 Gyr subject to additional uncertainties. The parameterization is applied to a representative modern day flux, providing quantitative estimates of the wavelength dependence of solar flux for paleodates relevant to the evolution of atmospheres in the solar system (or around other G-type stars). We validate the code by Monte Carlo analysis of uncertainties in stellar age and flux, and with comparisons to the solar proxies {kappa}{sup 1} Cet and EK Dra. The model is applied to the computation of photolysis rates on the Archean Earth.

  18. Ultraviolet relaxation dynamics of aniline, N, N-dimethylaniline and 3,5-dimethylaniline at 250 nm

    SciTech Connect (OSTI)

    Thompson, James O. F.; Saalbach, Lisa; Crane, Stuart W.; Paterson, Martin J.; Townsend, Dave

    2015-03-21

    Time-resolved photoelectron imaging was used to investigate the electronic relaxation dynamics of gas-phase aniline, N, N-dimethylaniline, and 3,5-dimethylaniline following ultraviolet excitation at 250 nm. Our analysis was supported by ab initio coupled-cluster calculations evaluating excited state energies and (in aniline) the evolution of a range of excited state physical properties as a function of N–H bond extension. Due to a lack of consistency between several earlier studies undertaken in aniline, the specific aim of this present work was to gain new insight into the previously proposed non-adiabatic coupling interaction between the two lowest lying singlet excited states S{sub 1}(ππ{sup ∗}) and S{sub 2}(3s/πσ{sup ∗}). The methyl-substituted systems N, N-dimethylaniline and 3,5-dimethylaniline were included in order to obtain more detailed dynamical information about the key internal molecular coordinates that drive the S{sub 1}(ππ{sup ∗})/S{sub 2}(3s/πσ{sup ∗}) coupling mechanism. Our findings suggest that in all three systems, both electronic states are directly populated during the initial excitation, with the S{sub 2}(3s/πσ{sup ∗}) state then potentially decaying via either direct dissociation along the N–X stretching coordinate (X = H or CH{sub 3}) or internal conversion to the S{sub 1}(ππ{sup ∗}) state. In aniline and N, N-dimethylaniline, both pathways most likely compete in the depletion of S{sub 2}(3s/πσ{sup ∗}) state population. However, in 3,5-dimethylaniline, only the direct dissociation mechanism appears to be active. This is rationalized in terms of changes in the relative rates of the two decay pathways upon methylation of the aromatic ring system.

  19. Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells

    SciTech Connect (OSTI)

    Luo, Fei; Xu, Yuan; Ling, Min; Zhao, Yue; Xu, Wenchao; Liang, Xiao; Jiang, Rongrong; Wang, Bairu; Bian, Qian; Liu, Qizhan

    2013-11-15

    Arsenite is an established human carcinogen, and arsenite-induced inflammation contributes to malignant transformation of cells, but the molecular mechanisms by which cancers are produced remain to be established. The present results showed that, evoked by arsenite, secretion of interleukin-6 (IL-6), a pro-inflammatory cytokine, led to the activation of STAT3, a transcription activator, and to increased levels of a microRNA, miR-21. Blocking IL-6 with anti-IL-6 antibody and inhibiting STAT3 activation reduced miR-21 expression. For human bronchial epithelial cells, cultured in the presence of anti-IL-6 antibody for 3 days, the arsenite-induced EMT and malignant transformation were reversed. Thus, IL-6, acting on STAT3 signaling, which up-regulates miR-21in an autocrine manner, contributes to the EMT induced by arsenite. These data define a link from inflammation to EMT in the arsenite-induced malignant transformation of HBE cells. This link, mediated through miRNAs, establishes a mechanism for arsenite-induced lung carcinogenesis. - Highlights: Arsenite evokes IL-6 secretion. IL-6 autocrine mediates STAT3 signaling and up-regulates miR-21expression. Inflammation is involved in arsenite-induced EMT.

  20. Differential cross sections for the reactions <mimi><mi>pmi><mi>pη> and <mimi><mi>pmi><mi>pmi><mi>η>'

    SciTech Connect (OSTI)

    Williams, M.; Krahn, Z.; Applegate, D.; Bellis, M.; Meyer, C. A.; Adhikari, K. P.; Anghinolfi, M.; Baghdasaryan, H.; Ball, J.; Battaglieri, M.; Bedlinskiy, I.; Berman, B. L.; Biselli, A. S.; Bookwalter, C.; Briscoe, W. J.; Brooks, W. K.; Burkert, V. D.; Careccia, S. L.; Carman, D. S.; Cole, P. L.; Collins, P.; Crede, V.; D’Angelo, A.; Daniel, A.; Vita, R. De; Sanctis, E. De; Deur, A.; Dey, B.; Dhamija, S.; Dickson, R.; Djalali, C.; Dodge, G. E.; Doughty, D.; Dugger, M.; Dupre, R.; Alaoui, A. El; Elouadrhiri, L.; Eugenio, P.; Fegan, S.; Fradi, A.; Gabrielyan, M. Y.; Garçon, M.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Gohn, W.; Golovatch, E.; Gothe, R. W.; Griffioen, K. A.; Guidal, M.; Guler, N.; Guo, L.; Hafidi, K.; Hakobyan, H.; Hanretty, C.; Hassall, N.; Hicks, K.; Holtrop, M.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jawalkar, S. S.; Jo, H. S.; Johnstone, J. R.; Joo, K.; Keller, D.; Khandaker, M.; Khetarpal, P.; Kim, W.; Klein, A.; Klein, F. J.; Kubarovsky, V.; Kuleshov, S. V.; Kuznetsov, V.; Livingston, K.; Lu, H. Y.; Mayer, M.; McAndrew, J.; McCracken, M. E.; McKinnon, B.; Mikhailov, K.; Mineeva, T.; Mirazita, M.; Mokeev, V.; Moriya, K.; Morrison, B.; Munevar, E.; Nadel-Turonski, P.; Nepali, C. S.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Niroula, M. R.; Niyazov, R. A.; Osipenko, M.; Ostrovidov, A. I.; Park, K.; Park, S.; Pasyuk, E.; Pereira, S. Anefalos; Perrin, Y.; Pieschacon, D.; Pisano, S.; Pogorelko, O.; Pozdniakov, S.; Price, J. W.; Procureur, S.; Prok, Y.; Protopopescu, D.; Raue, B. A.; Ricco, G.; Ripani, M.; Ritchie, B. G.; Rosner, G.; Rossi, P.; Sabatié, F.; Saini, M. S.; Salamanca, J.; Salgado, C.; Schott, D.; Schumacher, R. A.; Seraydaryan, H.; Sharabian, Y. G.; Smith, E. S.; Sober, D. I.; Sokhan, D.; Stepanyan, S. S.; Stoler, P.; Strakovsky, I. I.; Strauch, S.; Taiuti, M.; Tedeschi, D. J.; Tkachenko, S.; Ungaro, M.; Vineyard, M. F.; Voutier, E.; Watts, D. P.; Weinstein, L. B.; Weygand, D. P.; Wood, M. H.; Zhang, J.; Zhao, B.

    2009-10-29

    In high-statistics differential cross sections for the reactions γ p -> p η and γ p -> p η' the CLAS at Jefferson Lab was used to measure the center-of-mass energies from near threshold up to 2.84 GeV. The eta-prime results are the most precise to date and provide the largest energy and angular coverage. The eta measurements extend the energy range of the world's large-angle results by approximately 300 MeV. These new data, in particular the η' measurements, are likely to help constrain the analyses being performed to search for new baryon resonance states.

  1. Suppression of roll-off characteristics of organic light-emitting diodes by narrowing current injection/transport area to 50?nm

    SciTech Connect (OSTI)

    Hayashi, Kyohei Inoue, Munetomo; Yoshida, Kou; Nakanotani, Hajime; Mikhnenko, Oleksandr; Nguyen, Thuc-Quyen E-mail: adachi@cstf.kyushu-u.ac.jp; Adachi, Chihaya E-mail: adachi@cstf.kyushu-u.ac.jp

    2015-03-02

    Using e-beam nanolithography, the current injection/transport area in organic light-emitting diodes (OLEDs) was confined into a narrow linear structure with a minimum width of 50?nm. This caused suppression of Joule heating and partial separation of polarons and excitons, so the charge density where the electroluminescent efficiency decays to the half of the initial value (J{sub 0}) was significantly improved. A device with a narrow current injection width of 50?nm exhibited a J{sub 0} that was almost two orders of magnitude higher compared with that of the unpatterned OLED.

  2. Mathematical simulation of the amplification of 1790-nm laser radiation in a nuclear-excited He Ar plasma containing nanoclusters of uranium compounds

    SciTech Connect (OSTI)

    Kosarev, V A; Kuznetsova, E E

    2014-02-28

    The possibility of applying dusty active media in nuclearpumped lasers has been considered. The amplification of 1790-nm radiation in a nuclear-excited dusty He Ar plasma is studied by mathematical simulation. The influence of nanoclusters on the component composition of the medium and the kinetics of the processes occurring in it is analysed using a specially developed kinetic model, including 72 components and more than 400 reactions. An analysis of the results indicates that amplification can in principle be implemented in an active laser He Ar medium containing 10-nm nanoclusters of metallic uranium and uranium dioxide. (lasers)

  3. Word Pro - Untitled1

    U.S. Energy Information Administration (EIA) Indexed Site

    State-Level Energy Consumption Estimates and Estimated Consumption per Capita, 2010 Consumption Consumption per Capita 14 U.S. Energy Information Administration / Annual Energy Review 2011 TX CA FL LA IL OH PA NY GA IN MI NC VA NJ TN WA KY AL MO MN WI SC OK CO IA MD AZ MA MS KS AR OR NE UT CT WV NM NV AK WY ID ND ME MT SD NH HI DE RI DC VT 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 0 2 4 6 8 10

  4. Ecloud Build-Up Simulations for the FNAL MI for a Mixed Fill Pattern: Dependence on Peak SEY and Pulse Intensity During the Ramp

    SciTech Connect (OSTI)

    Furman, M. A.

    2010-12-11

    We present simulation results of the build-up of the electron-cloud density n{sub e} in three regions of the FNAL Main Injector (MI) for a beam fill pattern made up of 5 double booster batches followed by a 6th single batch. We vary the pulse intensity in the range N{sub t} = (2-5) x 10{sup 13}, and the beam kinetic energy in the range E{sub k} = 8-120 GeV. We assume a secondary electron emission model qualitatively corresponding to TiN, except that we let the peak value of the secondary electron yield (SEY) {delta}{sub max} vary as a free parameter in a fairly broad range. Our main conclusions are: (1) At fixed N{sub t} there is a clear threshold behavior of n{sub e} as a function of {delta}{sub max} in the range {approx} 1.1-1.3. (2) At fixed {delta}{sub max}, there is a threshold behavior of n{sub e} as a function of N{sub t} provided {delta}{sub max} is sufficiently high; the threshold value of N{sub t} is a function of the characteristics of the region being simulated. (3) The dependence on E{sub k} is weak except possibly at transition energy. Most of these results were informally presented to the relevant MI personnel in April 2010.

  5. The Office of Minority Economic Impact (MI) was established in Fiscal Year 1979 pursuant to Section 641 Title V1, Part 3 of the National Energy Conservation Policy Act (Public Law 95-619), dated November 9, 1978

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Minority Economic Impact (MI) was established in Fiscal Year 1979 pursuant to Section 641 Title V1, Part 3 of the National Energy Conservation Policy Act (Public Law 95- 619), dated November 9, 1978. The following is MI's legislative mandate. PART 3 - - MINORITY ECONOMIC IMPACT SEC. 641. MINORITY ECONOMIC IMPACT. "(a) Establishment of Office of Minority Economic Impact -- Title II of the Department of Energy Organization Act (42 U.S.C. 7131 - - 7139) is amended by adding at the end thereof

  6. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: A combined of experimental and first-principles study

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wu, Qiyuan; Su, Dong; Xiong, Shangmin; Shen, Peichuan; Zhao, Shen; Li, Yan; Orlov, Alexander

    2014-12-24

    In this work we have explored a new concept of substantially increasing photocatalytic activity for H? production of conventional semiconductors by modifying them with sub-nm Pt particles. By combining both experimental and theoretical approaches, we have also developed new mechanistic insights into the 17 times increase in photocatalytic activity of Pt modified CdS catalysts.

  7. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: A combined of experimental and first-principles study

    SciTech Connect (OSTI)

    Wu, Qiyuan; Su, Dong; Xiong, Shangmin; Shen, Peichuan; Zhao, Shen; Li, Yan; Orlov, Alexander

    2014-12-24

    In this work we have explored a new concept of substantially increasing photocatalytic activity for H₂ production of conventional semiconductors by modifying them with sub-nm Pt particles. By combining both experimental and theoretical approaches, we have also developed new mechanistic insights into the 17 times increase in photocatalytic activity of Pt modified CdS catalysts.

  8. Synthesis and characterization of 10?nm thick piezoelectric AlN films with high c-axis orientation for miniaturized nanoelectromechanical devices

    SciTech Connect (OSTI)

    Zaghloul, Usama; Piazza, Gianluca

    2014-06-23

    The scaling of piezoelectric nanoelectromechanical systems (NEMS) is challenged by the synthesis of ultrathin and high quality piezoelectric films on very thin electrodes. We report the synthesis and characterization of the thinnest piezoelectric aluminum nitride (AlN) films (10?nm) ever deposited on ultrathin platinum layers (25?nm) using reactive sputtering. X-ray diffraction, high-resolution transmission electron microscopy, and fast Fourier transform analyses confirmed the proper crystal orientation, fine columnar texture, and the continuous lattice structure within individual grains in the deposited AlN nanometer thick films. The average extracted d{sub 31} piezoelectric coefficient for the synthesized films is ?1.73 pC/N, which is comparable to the reported values for micron thick and highly c-axis oriented AlN films. The 10?nm AlN films were employed to demonstrate two different types of optimized piezoelectric nanoactuators. The unimorph actuators exhibit vertical displacements as large as 1.1??m at 0.7?V for 25??m long and 30?nm thick beams. These results have a great potential to realize miniaturized NEMS relays with extremely low voltage, high frequency resonators, and ultrasensitive sensors.

  9. Near-resonance enhanced O2 detection for dual-broadband pure rotational coherent anti-Stokes Raman scattering with an ultraviolet-visible setup at 266 nm

    SciTech Connect (OSTI)

    Schenk, Martin; Seeger, Thomas; Leipertz, Alfred

    2005-07-01

    Broadband and dual-broadband coherent anti-Stokes Raman scattering (CARS) are widely established tools for nonintrusive gas diagnostics. Up to now the investigations have been mainly performed for electronic nonresonant conditions of the gas species of interest. We report on the enhancement of the O2-N2 detection limit of dual-broadband pure rotational CARS by shifting the wavelength of the narrowband pump laser from the commonly used 532-266 nm. This enhancement is caused when the Schumann-Runge absorption band is approached near 176 nm. The principal concept of this experiment, i.e., covering the Raman resonance with a single- or dual-broadband combination of lasers in the visible range and moving only the narrowband probe laser near or directly into electronic resonant conditions in the UV range, should also be applicable to broadband CARS experiments to directly exploit electronic resonance effects for the purpose of single-shot concentration measurements of minority species. To quantify the enhancement in O2 sensitivity, comparative measurements at both a 266 and a 532 nm narrowband pump laser wavelength are presented, employing a 4-dicyanomethylene-2-methyl-6-(p-dimethylaminostyryl)-4H-pyram (DCM) dye laser as a broadband laser source at 635 nm. An increase of approximately 13% in the ratio of the rotational CARS cross sections of O2 and N2 was obtained. The broad spectral width of the CARS excitation profile was approximately equal for both setups. Further enhancement should be achievable by shifting the narrowband pump laser closer toward 176 nm, for example, with a frequency-doubled optical parametric oscillator or an excimer laser. The principal concept of this experiment should also be applicable to broadband CARS experiments to directly exploit electronic resonance effects of the narrowband pump laser with electronic transitions of minority species for the purpose of single-shot concentration measurements of those species.

  10. Optimized Bose-Einstein-condensate production in a dipole trap based on a 1070-nm multifrequency laser: Influence of enhanced two-body loss on the evaporation process

    SciTech Connect (OSTI)

    Lauber, T.; Kueber, J.; Wille, O.; Birkl, G.

    2011-10-15

    We present an optimized strategy for the production of tightly confined Bose-Einstein condensates (BEC) of {sup 87}Rb in a crossed dipole trap with direct loading from a magneto-optical trap. The dipole trap is created with light of a multifrequency fiber laser with a center wavelength of 1070 nm. Evaporative cooling is performed by ramping down the laser power only. A comparison of the resulting atom number in an almost pure BEC to the initial atom number and the value for the gain in phase space density per atom lost confirm that this straightforward strategy is very efficient. We observe that the temporal characteristics of evaporation sequence are strongly influenced by power-dependent two-body losses resulting from enhanced optical pumping to the higher-energy hyperfine state. We characterize these losses and compare them to results obtained with a single-frequency laser at 1030 nm.

  11. High-Resolution PFPE-based Molding Techniques for Nanofabrication of High-Pattern Density, Sub-20 nm Features: A Fundamental Materials Approach

    SciTech Connect (OSTI)

    Williams, Stuart S.; Retterer, Scott; Lopez, Rene; Ruiz, Ricardo; Samulski, Edward T.; DeSimone, Joseph M.

    2010-04-14

    Several perfluoropolyether (PFPE)-based elastomers for high-resolution replica molding applications are explored. The modulus of the elastomeric materials was increased through synthetic and additive approaches while maintaining relatively low surface tension values (<25 mN/m). Using large area (>4 in.{sup 2}) master templates, we experimentally show the relationship between mold resolution and material properties such as modulus and surface tension for materials used in this study. A composite mold approach was used to form flexible molds out of stiff, high modulus materials that allow for replication of sub-20 nm post structures. Sub-100 nm line grating master templates, formed using e-beam lithography, were used to determine the experimental stability of the molding materials. It was observed that as the feature spacing decreased, high modulus PFPE tetramethacrylate (TMA) composite molds were able to effectively replicate the nanograting structures without cracking or tear-out defects that typically occur with high modulus elastomers.

  12. 1.9 W continuous-wave single transverse mode emission from 1060?nm edge-emitting lasers with vertically extended lasing area

    SciTech Connect (OSTI)

    Miah, M. J. Posilovic, K.; Kalosha, V. P.; Rosales, R.; Bimberg, D.; Kettler, T.; Skoczowsky, D.; Pohl, J.; Weyers, M.

    2014-10-13

    High-brightness edge-emitting semiconductor lasers having a vertically extended waveguide structure emitting in the 1060?nm range are investigated. Ridge waveguide (RW) lasers with 9??m stripe width and 2.64?mm cavity length yield highest to date single transverse mode output power for RW lasers in the 1060?nm range. The lasers provide 1.9 W single transverse mode optical power under continuous-wave (cw) operation with narrow beam divergences of 9 in lateral and 14 (full width at half maximum) in vertical direction. The beam quality factor M{sup 2} is less than 1.9 up to 1.9 W optical power. A maximum brightness of 72 MWcm{sup ?2}sr{sup ?1} is obtained. 100??m wide and 3?mm long unpassivated broad area lasers provide more than 9 W optical power in cw operation.

  13. Strong carrier localization effect in carrier dynamics of 585 nm InGaN amber light-emitting diodes

    SciTech Connect (OSTI)

    Li, Panpan; Li, Hongjian; Li, Zhi; Kang, Junjie; Yi, Xiaoyan; Li, Jinmin; Wang, Guohong

    2015-02-21

    Temperature dependence and time-resolved photoluminescence (TRPL) have been carried out to study carrier dynamics for 585 nm InGaN amber light-emitting diodes (LEDs). It is found that in InGaN amber LEDs, peak emission energy only shows a slight blueshift from 588 to 575 nm, as temperature increased from 10 K to 300 K. Moreover, radiative recombination lifetime has demonstrated independent of temperature based TRPL results. These two features indicate that a strong carrier localization effect plays a dominant role in carrier dynamics for InGaN amber LEDs. Also, activation energy of 40.3 meV is obtained through Arrhenius plot of PL intensity versus temperature.

  14. Simultaneous near-field and far-field imaging of the 11.9-nm Ni-like Sn soft-x-ray laser

    SciTech Connect (OSTI)

    Staub, F.; Braud, M.; Balmer, J.E.; Nilsen, J.; Bajt, S.

    2004-07-01

    We report on two-dimensional near-field imaging experiments of the 11.9-nm Sn x-ray laser that were performed with a set of Mo/Y multilayer mirrors having reflectivities of up to {approx}45% at normal and at 45 deg. incidence. Second-moment analysis of the x-ray laser emission was used to determine values of the x-ray beam propagation factor M{sup 2} for a range of irradiation parameters. The results reveal a reduction of M{sup 2} with increasing prepulse amplitude. The spatial size of the output is a factor of {approx}2 smaller than previously measured for the 14.7-nm Pd x-ray laser, while the distance of the x-ray emission with respect to the target surface remains roughly the same.

  15. Linear and nonlinear transmission of Fe{sup 2+}-doped ZnSe crystals at a wavelength of 2940 nm in the temperature range 20220 C

    SciTech Connect (OSTI)

    Il'ichev, N N; Pashinin, P P; Gulyamova, E S; Bufetova, G A; Shapkin, P V; Nasibov, A S

    2014-03-28

    The linear and nonlinear transmission of Fe{sup 2+}:ZnSe crystals is measured at a wavelength of 2940 nm in the temperature range 20 220 C. It is found that, with increasing temperature from 20 C to 150 220 C, the transmission of Fe{sup 2+}:ZnSe crystals decreases in the case of incident radiation with an intensity of ?5.5 MW cm{sup -2} and increases in the case of radiation with an intensity of 28 kW cm{sup -2}. At a temperature of 220 C, the linear transmission almost coincides with the nonlinear transmission. The transmission spectra of Fe{sup 2+}:ZnSe crystals at temperatures of 22 and 220 C in the wavelength range 500 7000 nm are presented. (active media)

  16. Gas-phase photodissociation of CH{sub 3}COCN at 308 nm by time-resolved Fourier-transform infrared emission spectroscopy

    SciTech Connect (OSTI)

    Yeh, Yu-Ying; Chao, Meng-Hsuan; Tsai, Po-Yu; Chang, Yuan-Bin; Tsai, Ming-Tsang; Lin, King-Chuen

    2012-01-28

    By using time-resolved Fourier-transform infrared emission spectroscopy, the fragments of HCN(v= 1, 2) and CO(v= 1-3) are detected in one-photon dissociation of acetyl cyanide (CH{sub 3}COCN) at 308 nm. The S{sub 1}(A'), {sup 1}(n{sub O}, {pi}*{sub CO}) state at 308 nm has a radiative lifetime of 0.46 {+-} 0.01 {mu}s, long enough to allow for Ar collisions that induce internal conversion and enhance the fragment yields. The rate constant of Ar collision-induced internal conversion is estimated to be (1-7) x 10{sup -12} cm{sup 3} molecule{sup -1} s{sup -1}. The measurements of O{sub 2} dependence exclude the production possibility of these fragments via intersystem crossing. The high-resolution spectra of HCN and CO are analyzed to determine the ro-vibrational energy deposition of 81 {+-} 7 and 32 {+-} 3 kJ/mol, respectively. With the aid of ab initio calculations, a two-body dissociation on the energetic ground state is favored leading to HCN + CH{sub 2}CO, in which the CH{sub 2}CO moiety may further undergo secondary dissociation to release CO. The production of CO{sub 2} in the reaction with O{sub 2} confirms existence of CH{sub 2} and a secondary reaction product of CO. The HNC fragment is identified but cannot be assigned, as restricted to a poor signal-to-noise ratio. Because of insufficient excitation energy at 308 nm, the CN and CH{sub 3} fragments that dominate the dissociation products at 193 nm are not detected.

  17. Low Group Delay Dispersion Optical Coating for Broad Bandwidth High Reflection at 45° Incidence, P Polarization of Femtosecond Pulses with 900 nm Center Wavelength

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Bellum, John C.; Field, Ella S.; Winstone, Trevor B.; Kletecka, Damon E.

    2016-03-01

    We describe an optical coating design suitable for broad bandwidth high reflection (BBHR) at 45° angle of incidence (AOI), P polarization (Ppol) of femtosecond (fs) laser pulses whose wavelengths range from 800 to 1000 nm. The design process is guided by quarter-wave HR coating properties. Our design must afford low group delay dispersion (GDD) for reflected light over the broad, 200 nm bandwidth in order to minimize temporal broadening of the fs pulses due to dispersive alteration of relative phases between their frequency components. The design should also be favorable to high laser-induced damage threshold (LIDT). We base the coatingmore » on TiO2/SiO2 layer pairs produced by means of e-beam evaporation with ion-assisted deposition, and use OptiLayer Thin Film Software to explore designs starting with TiO2/SiO2 layers having thicknesses in a reverse chirped arrangement. This approach led to a design with R > 99% from 800 to 1000 nm and GDD < 20 fs2 from 843 to 949 nm (45° AOI, Ppol). The design’s GDD behaves in a smooth way, suitable for GDD compensation techniques, and its electric field intensities show promise for high LIDTs. Reflectivity and GDD measurements for the initial test coating indicate good performance of the BBHR design. Subsequent coating runs with improved process calibration produced two coatings whose HR bands satisfactorily meet the design goals. Lastly, for the sake of completeness, we summarize our previously reported transmission spectra and LIDT test results with 800 ps, 8 ps and 675 fs pulses for these two coatings, and present a table of the LIDT results we have for all of our TiO2/SiO2 BBHR coatings, showing the trends with test laser pulse duration from the ns to sub-ps regimes.« less

  18. Comparison of 20 nm silver nanoparticles synthesized with and without a gold core. Structure, dissolution in cell culture media, and biological impact on macrophages

    SciTech Connect (OSTI)

    Munusamy, Prabhakaran; Wang, Chongmin; Engelhard, Mark H.; Baer, Donald R.; Smith, Jordan N.; Liu, Chongxuan; Kodali, Vamsi K.; Thrall, Brian D.; Chen, Shu; Porter, Alexandra E.; Ryan, Mary P.

    2015-07-15

    Widespread use of silver nanoparticles raises questions of environmental impact and toxicity. Both silver particles and silver ions formed by particle dissolution may impact biological systems. Therefore it is important to understand the characteristics of silver nanoparticles and their stability in relevant media. The synthesis route can impact physical and chemical characteristics of the particles and we report the characterization and solution stability of three types of silver nanoparticles (20 nm particles with and without gold cores and 110 nm particles with gold cores) in cell culture media with serum proteins: FBS10%/RPMI. These nanoparticles were synthesized in aqueous solution and characterized using both in situ and ex situ analysis methods. Dissolution studies were carried at particle concentrations from 1 µg/ml to 50 µg/ml. Particles with gold cores had smaller crystallite size and higher apparent solubility than pure silver particles. A dissolution model was found to describe the time variation of particle size and amount of dissolved silver for particle loadings above 9 µg/ml. An effective solubility product obtained from fitting the data was higher for the 20 nm gold core particles in comparison to the pure silver or 110 nm particles. Dissolution of the nanoparticles was enhanced by presence of serum proteins contained in fetal bovine serum. In addition, the protocol of the dispersion in the medium was found to influence particle agglomeration and dissolution. Results show that particle structure can impact the concentration of dissolved silver and the dose to which cells would be exposed during in vitro studies.

  19. Comparison of 20 nm silver nanoparticles synthesized with and without a gold core. Structure, dissolution in cell culture media, and biological impact on macrophages

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Munusamy, Prabhakaran; Wang, Chongmin; Engelhard, Mark H.; Baer, Donald R.; Smith, Jordan N.; Liu, Chongxuan; Kodali, Vamsi K.; Thrall, Brian D.; Chen, Shu; Porter, Alexandra E.; et al

    2015-07-15

    Widespread use of silver nanoparticles raises questions of environmental impact and toxicity. Both silver particles and silver ions formed by particle dissolution may impact biological systems. Therefore it is important to understand the characteristics of silver nanoparticles and their stability in relevant media. The synthesis route can impact physical and chemical characteristics of the particles and we report the characterization and solution stability of three types of silver nanoparticles (20 nm particles with and without gold cores and 110 nm particles with gold cores) in cell culture media with serum proteins: FBS10%/RPMI. These nanoparticles were synthesized in aqueous solution andmore » characterized using both in situ and ex situ analysis methods. Dissolution studies were carried at particle concentrations from 1 µg/ml to 50 µg/ml. Particles with gold cores had smaller crystallite size and higher apparent solubility than pure silver particles. A dissolution model was found to describe the time variation of particle size and amount of dissolved silver for particle loadings above 9 µg/ml. An effective solubility product obtained from fitting the data was higher for the 20 nm gold core particles in comparison to the pure silver or 110 nm particles. Dissolution of the nanoparticles was enhanced by presence of serum proteins contained in fetal bovine serum. In addition, the protocol of the dispersion in the medium was found to influence particle agglomeration and dissolution. Results show that particle structure can impact the concentration of dissolved silver and the dose to which cells would be exposed during in vitro studies.« less

  20. MaRIE 1.0: A briefing to Katherine Richardson-McDaniel, Staff Member for U. S. Senator Martin Heinrich (D-NM)

    SciTech Connect (OSTI)

    Barnes, Cris William

    2015-02-24

    At the request of Katherine Richardson-McDaniel, Staff Member to U.S. Senator Martin Heinrich (D-NM), a high-level briefing was requested about MaRIE 1.0, the Matter-Radiation Interactions in Extremes effort at Los Alamos National Laboratory. What it would be, the mission need motivation, the scientific challenge, and the current favorable impact on both programs and people are shown in viewgraph form.

  1. Comprehensive Characterization of Voids and Microstructure in TATB-based Explosives from 10 nm to 1 cm: Effects of Temperature Cycling and Compressive Creep

    SciTech Connect (OSTI)

    Willey, T M; Lauderbach, L; Gagliardi, F; Cunningham, B; Lorenz, K T; Lee, J I; van Buuren, T; Call, R; Landt, L; Overturf, G

    2010-02-26

    This paper outlines the characterization of voids and Microstructure in TATB-based Explosives over several orders of magnitude, from sizes on the order of 10 nm to about 1 cm. This is accomplished using ultra small angle x-ray scattering to investigate voids from a few nm to a few microns, ultra small angle neutron scattering for voids from 100 nm to 10 microns, and x-ray computed microtomography to investigate microstructure from a few microns to a few centimeters. The void distributions of LX-17 are outlined, and the microstructure of LX-17 is presented. Temperature cycling and compressive creep cause drastically different damage to the microstructure. Temperature cycling leads to a volume expansion (ratchet growth) in TATB-based explosives, and x-ray scattering techniques that are sensitive to sizes up to a few microns indicated changes to the void volume distribution that had previously accounted for most, but not all of the change in density. This paper presents the microstructural damage larger than a few microns caused by ratchet growth. Temperature cycling leads to void creation in the binder poor regions associated with the interior portion of formulated prills. Conversely, compressive creep causes characteristically different changes to microstructure; fissures form at binder-rich prill boundaries prior to mechanical failure.

  2. Fabrication of nanoscale patterns in lithium fluoride crystal using a 13.5 nm Schwarzschild objective and a laser produced plasma source

    SciTech Connect (OSTI)

    Wang Xin; Mu Baozhong; Jiang Li; Zhu Jingtao; Yi Shengzhen; Wang Zhanshan; He Pengfei

    2011-12-15

    Lithium fluoride (LiF) crystal is a radiation sensitive material widely used as EUV and soft x-ray detector. The LiF-based detector has high resolution, in principle limited by the point defect size, large field of view, and wide dynamic range. Using LiF crystal as an imaging detector, a resolution of 900 nm was achieved by a projection imaging of test meshes with a Schwarzschild objective operating at 13.5 nm. In addition, by imaging of a pinhole illuminated by the plasma, an EUV spot of 1.5 {mu}m diameter in the image plane of the objective was generated, which accomplished direct writing of color centers with resolution of 800 nm. In order to avoid sample damage and contamination due to the influence of huge debris flux produced by the plasma source, a spherical normal-incidence condenser was used to collect EUV radiation. Together with a description of experimental results, the development of the Schwarzschild objective, the influence of condenser on energy density and the alignment of the imaging system are also reported.

  3. Sub-10 nm lanthanide doped BaLuF{sub 5} nanocrystals: Shape controllable synthesis, tunable multicolor emission and enhanced near-infrared upconversion luminescence

    SciTech Connect (OSTI)

    Rao, Ling; Lu, Wei; Wang, Haibo; Yi, Zhigao; Zeng, Songjun; Li, Zheng

    2015-04-15

    Highlights: • Sub-10 nm cubic phase BaLuF{sub 5} nanocrystals were synthesized by a hydrothermal method for the first time. • Tunable multicolor from yellow to yellow-green was achieved by controlling Gd{sup 3+} content in BaLuF{sub 5}:Yb/Er system. • Intense near-infrared upconversion luminescence in BaLuF{sub 5}:Gd/Yb/Tm nanocrystal. • The enhancement near-infrared luminescence can be realized by adjusting the content of Gd{sup 3+} in BaLuF{sub 5}:Gd/Yb/Tm system. - Abstract: In this study, sub-10 nm BaLuF{sub 5} nanocrystals with cubic phase structure were synthesized by a solvothermal method using oleic acid as the stabilizing agent. The as-prepared BaLuF{sub 5} nanocrystals were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), and analyzed by the upconversion (UC) spectra. The TEM results reveal that these samples present high uniformity. Compared with Gd-free samples, the size of BaLuF{sub 5}:Yb/Er doped with 10% Gd{sup 3+} decreased to 5.6 nm. In addition, BaLuF{sub 5}:Yb/Tm/Gd upconversion nanoparticles (UCNPs) presented efficient near-infrared (NIR)-NIR UC luminescence. Therefore, it is expected that these ultra-small BaLuF{sub 5} nanocrystals with well-controlled shape, size, and UC emission have potential applications in biomedical imaging fields.

  4. 17β-Estradiol regulates cell proliferation, colony formation, migration, invasion and promotes apoptosis by upregulating miR-9 and thus degrades MALAT-1 in osteosarcoma cell MG-63 in an estrogen receptor-independent manner

    SciTech Connect (OSTI)

    Fang, Dengfeng; Yang, Hui; Lin, Jing; Teng, Yi; Jiang, Yingying; Chen, Jiao; Li, Yu

    2015-02-20

    In bone, different concentration of estrogen leads to various of physiological processes in osteoblast, such as the proliferation, migration, and apoptosis in an estrogen receptor-dependent manner. But little was known about the estrogen effects on osteosarcoma (OS). In this study, OS cell MG-63 was treated with low (1 nM) or high (100 nM) dose of 17β-Estradiol (E2) with the presence or absence of estrogen receptor α (ERα), for evaluating the E2 effects on proliferation, migration, invasion, colony formation and apoptosis. Consistent with a previous study, high dose of E2 treatment dramatically downregulated expressing level of long non-coding RNA metastasis associated lung adenocarcinoma transcript 1 (MALAT-1). The observation of upregulation of miR-9 after a high dose of E2 treatment indicated the cause of MALAT-1 reduction. Downregulation of MALAT-1 promoted the combination of SFPQ/PTBP2 complex. It was also observed that the proliferation, migration, invasion, colony formation and apoptosis of OS cells were remarkably affected by high dose of E2 treatment, but not by low dose, in an ERα independent manner. Furthermore, the abolishment of the effects on these physiological processes caused by ectopic expression of miR-9 ASOs suggested the necessity of miR-9 in MALAT-1 regulation. Here we found that the high dose of E2 treatment upregulated miR-9 thus posttranscriptionally regulated MALAT-1 RNA level in OS cells, and then the downregulation of MALAT-1 inhibited cell proliferation, migration, invasion and epithelial–mesenchymal transition (EMT) processes in the E2-dose dependent and ER-independent ways. - Highlights: • E2 affects osteosarcoma cell MG-63 in an Estrogen receptor-independent way. • High dose of E2 treatment upregulates miR-9 which target to MALAT-1 RNA. • Upregulated miR-9 degrades MALAT-1 and thus affects combination of SFPQ/PTBP2. • E2 treatment block cell proliferation, colony formation, mobility, and enhance apoptosis.

  5. Absorption enhancement through Fabry-Prot resonant modes in a 430?nm thick InGaAs/GaAsP multiple quantum wells solar cell

    SciTech Connect (OSTI)

    Behaghel, B.; Tamaki, R.; Watanabe, K.; Sodabanlu, H.; Vandamme, N.; Dupuis, C.; Bardou, N.; Cattoni, A.; Okada, Y.; Sugiyama, M.; Collin, S.; Guillemoles, J.-F.

    2015-02-23

    We study light management in a 430?nm-thick GaAs p-i-n single junction solar cell with 10 pairs of InGaAs/GaAsP multiple quantum wells (MQWs). The epitaxial layer transfer on a gold mirror improves light absorption and increases the external quantum efficiency below GaAs bandgap by a factor of four through the excitation of Fabry-Perot resonances. We show a good agreement with optical simulation and achieve around 10% conversion efficiency. We demonstrate numerically that this promising result can be further improved by anti-reflection layers. This study paves the way to very thin MQWs solar cells.

  6. Hard x-ray contact microscopy with 250 nm spatial resolution using a LiF film detector and a tabletop microsource

    SciTech Connect (OSTI)

    Almaviva, S.; Bonfigli, F.; Franzini, I.; Lai, A.; Montereali, R. M.; Pelliccia, D.; Cedola, A.; Lagomarsino, S.

    2006-07-31

    An innovative route for deep-submicrometer spatial resolution hard x-ray microscopy with tabletop x-ray source is proposed. A film of lithium fluoride (LiF) was used as imaging detector in contact mode. We present here the x-ray images recorded on LiF films of a Fresnel zone plate with submicrometer gold structures and of an onion cataphyll. The images were read with an optical confocal microscope in fluorescence mode. The measured spatial resolution was about 250 nm, i.e., close to the resolution limit of the confocal microscope. The advantages and drawbacks, and the possible improvements, of this route are discussed.

  7. Observation of coupled vortex gyrations by 70-ps-time and 20-nm-space- resolved full-field magnetic transmission soft x-ray microscopy

    SciTech Connect (OSTI)

    Jung, Hyunsung; Yu, Young-Sang; Lee, Ki-Suk; Im, Mi-Young; Fischer, Peter; Bocklage, Lars; Vogel, Andreas; Bolte, Markus; Meier, Guido; Kim, Sang-Koog

    2010-09-01

    We employed time-and space-resolved full-field magnetic transmission soft x-ray microscopy to observe vortex-core gyrations in a pair of dipolar-coupled vortex-state Permalloy (Ni{sub 80}Fe{sub 20}) disks. The 70 ps temporal and 20 nm spatial resolution of the microscope enabled us to simultaneously measure vortex gyrations in both disks and to resolve the phases and amplitudes of both vortex-core positions. We observed their correlation for a specific vortex-state configuration. This work provides a robust and direct method of studying vortex gyrations in dipolar-coupled vortex oscillators.

  8. Uranium Mill Tailings Remedial Action Project Annual Environmental Monitoring Report calendar year 1992: Volume 2

    SciTech Connect (OSTI)

    1993-12-31

    This report contains environmental monitoring information for the following UMTRA sites for the 1992 Calendar Year: Lakeview, OR; Lowman, ID; Mexican Hat, UT; Monument Valley, AZ; Rifle, CO; Riverton, WY; Shiprock, NM; Spook, WY; Tuba City, AZ. Each site report contains a site description, compliance summary, environmental program information, environmental radiological and non-radiological program information, water resources protection, and quality assurance information.

  9. DOE FAIR 2007 (OMB).xls

    Broader source: Energy.gov (indexed) [DOE]

    I Z 1999 40 19-05 AL NNSA NM Albuquerque US 1 P119 I Z 1999 41 19-05 AL NNSA AZ Fort Smith US 1 T999 C B 1999 42 19-05 AL NNSA AZ Fort Smith US 1 T999 I Z 1999 43 19-05 AL NNSA...

  10. Towards sub-200 nm nano-structuring of linear giant magneto-resistive spin valves by a direct focused ion beam milling process

    SciTech Connect (OSTI)

    Riedmüller, Benjamin; Huber, Felix; Herr, Ulrich

    2014-02-14

    In this work, we present a detailed investigation of a focused ion beam (FIB) assisted nano-structuring process for giant magneto-resistive (GMR) spin valve sensors. We have performed a quantitative study of the dependence of the GMR ratio as well as the sensor resistance on the ion dose, which is implanted in the active region of our sensors. These findings are correlated with the decrease of magneto-resistive properties after micro- and nano-structuring by the FIB and reveal the importance of ion damage which limits the applicability of FIB milling to GMR devices in the low μm range. Deposition of a protective layer (50 nm SiO{sub 2}) on top of the sensor structure before milling leads to a preservation of the magneto-resistive properties after the milling procedure down to sensor dimensions of ∼300 nm. The reduction of the sensor dimensions to the nanometer regime is accompanied by a shift of the GMR curves, and a modification of the saturation behavior. Both effects can be explained by a micromagnetic model including the magnetic interaction of free and pinned layer as well as the effect of the demagnetizing field of the free layer on the sensor behavior. The results demonstrate that the FIB technology can be successfully used to prepare spintronic nanostructures.

  11. Direct Aqueous-Phase Synthesis of Sub-10 nm “Luminous Pearls” with Enhanced in Vivo Renewable Near-Infrared Persistent Luminescence

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Li, Zhanjun; Zhang, Yuanwei; Wu, Xiang; Huang, Ling; Li, Dongsheng; Fan, Wei; Han, Gang

    2015-04-02

    Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs), possessing unique NIR PL properties, have recently emerged as important materials for a wide variety of applications in chemistry and biology, for which they must endure high-temperature solid-state annealing reactions and subsequent complicated physical post-treatments. Herein, we report on a first direct aqueous-phase chemical synthesis route to NIR PLNPs and present their enhanced in vivo renewable NIR PL. Our method leads to monodisperse PLNPs as small as ca. 8 nm. Such sub-10 nm nanocrystals are readily dispersed and functionalized, and can form stable colloidal solutions in aqueous solution and cell culture medium for biologicalmore » applications. Under biotissue-penetrable red-light excitation, we found that such nanocrystals possess superior renewable PL photoluminescence in vitro and in vivo compared to their larger counterparts currently made by existing methods. In conclusion, we believe that this solid-state-reaction-free chemical approach overcomes the current key roadblock in regard to PLNP development, and thus will pave the way to broad use of these advanced miniature “luminous pearls” in photonics and biophotonics.« less

  12. Extracting the mass dependence and quantum numbers of short-range correlated pairs from <mi>Ami>(<mi>emi>,<mi>emi>'<mi>p>) and <mi>Ami>(<mi>emi>,<mi>emi>'<mi>pp>) scattering

    SciTech Connect (OSTI)

    Colle, C.; Hen, O.; Cosyn, W.; Korover, I.; Piasetzky, E.; Ryckebusch, J.; Weinstein, L. B.

    2015-08-06

    We present an analysis of electroinduced single-proton and two-proton knockout measurements off 12C, 27Al, 56Fe, and 208Pb in kinematics dominated by scattering off SRC pairs.

  13. NM, East Proved Nonproducing Reserves

    U.S. Energy Information Administration (EIA) Indexed Site

    149 180 185 232 304 460 1996-2014 Lease Condensate (million bbls) 12 16 18 29 25 15 1998-2014 Total Gas (billion cu ft) 1,052 1,216 1,358 1,306 1,447 2,085 1996-2014 Nonassociated Gas (billion cu ft) 649 664 701 660 434 478 1996-2014 Associated Gas (billion cu ft) 403 552 657 646 1,013 1,607

  14. NM, West Proved Nonproducing Reserves

    U.S. Energy Information Administration (EIA) Indexed Site

    0 0 0 0 10 29 1996-2014 Lease Condensate (million bbls) 1 1 4 4 3 5 1998-2014 Total Gas (billion cu ft) 2,732 2,384 2,098 1,349 951 945 1996-2014 Nonassociated Gas (billion cu ft) 2,727 2,379 2,093 1,345 935 899 1996-2014 Associated Gas (billion cu ft) 5 5 5 4 16 46

  15. Photoelectron imaging and theoretical study on the structure and chemical binding of the mixed-ligand M(I) complexes, [HMSH]{sup ?} (M = Cu, Ag, and Au)

    SciTech Connect (OSTI)

    Qin, Zhengbo; Liu, Zhiling; Cong, Ran; Xie, Hua; Tang, Zichao, E-mail: zctang@dicp.ac.cn, E-mail: fanhj@dicp.ac.cn; Fan, Hongjun, E-mail: zctang@dicp.ac.cn, E-mail: fanhj@dicp.ac.cn [State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China)] [State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023 (China)

    2014-03-21

    We have reported a combined photoelectron imaging and theoretical study on gaseous mixed-ligand M(I) complexes of [HMSH]{sup ?} (M = Cu, Ag, and Au). With the aid of Franck-Condon simulations, vibrationally resolved photoelectron spectra yield accurate electron affinities of 3.269(6), 3.669(10), and 3.591(6) eV for [HCuSH], [HAgSH], and [HAuSH], respectively. And low-frequency modes are observed: 368(12) cm{sup ?1} for [HCuSH], 286(12) cm{sup ?1} for [HAgSH], and 327(12) cm{sup ?1} for [HAuSH], respectively. Extensive theoretical calculations are performed to aid in the spectral assignments and the calculated values agree well with the experimental observations. Although the S and H atoms have little discrepancy in electronegativity (2.20 for H and 2.54 for S), distinct bonding properties are demonstrated between HM and MS bond. It is revealed that there exists significant ionic bonding between MS in [HMSH]{sup ?} (M = Cu, Ag, and Au), while a gradual transition from ionic behavior between HCu in [HCuSH]{sup ?} to quite strong covalent bonding between HAu in [HAuSH]{sup ?}, supported by a variety of chemical bonding analyses.

  16. Improved Measurement of the <mi>?>?<mi mathvariant='normal'>emi>?> Branching Ratio

    SciTech Connect (OSTI)

    Aguilar-Arevalo, A.; Aoki, M.; Blecher, M.; Britton, D. I.; Bryman, D. A.; vom Bruch, D.; Chen, S.; Comfort, J.; Ding, M.; Doria, L.; Cuen-Rochin, S.; Gumplinger, P.; Hussein, A.; Igarashi, Y.; Ito, S.; Kettell, S. H.; Kurchaninov, L.; Littenberg, L. S.; Malbrunot, C.; Mischke, R. E.; Numao, T.; Protopopescu, D.; Sher, A.; Sullivan, T.; Vavilov, D.; Yamada, K.

    2015-08-01

    A new measurement of the branching ratio Re/?=?(?+ ? e+? + ?+ ? e+??)/?(?+ ? ?+? + ?+??+??) resulted in Rexpe/?=[1.23440.0023(stat)0.0019(syst)] x 10-4. This is in agreement with the standard model prediction and improves the test of electron-muon universality to the level of 0.1%.

  17. A Pixel Readout Chip in 40 nm CMOS Process for High Count Rate Imaging Systems with Minimization of Charge Sharing Effects

    SciTech Connect (OSTI)

    Maj, Piotr; Grybos, P.; Szczgiel, R.; Kmon, P.; Drozd, A.; Deptuch, G.

    2013-11-07

    We present a prototype chip in 40 nm CMOS technology for readout of hybrid pixel detector. The prototype chip has a matrix of 18x24 pixels with a pixel pitch of 100 ?m. It can operate both in single photon counting (SPC) mode and in C8P1 mode. In SPC the measured ENC is 84 e? rms (for the peaking time of 48 ns), while the effective offset spread is below 2 mV rms. In the C8P1 mode the chip reconstructs full charge deposited in the detector, even in the case of charge sharing, and it identifies a pixel with the largest charge deposition. The chip architecture and preliminary measurements are reported.

  18. Holographic recording and characterization of photorefractive Bi{sub 2}TeO{sub 5} crystals at 633?nm wavelength light

    SciTech Connect (OSTI)

    Oliveira, Ivan de

    2014-04-28

    We report on the holographic recording on photorefractive Bi{sub 2}TeO{sub 5} crystals using ?=633 nm wavelength light. We studied the behavior of this material under the action of this low photonic energy light and found out the presence of a fast and a slow hologram, both of photorefractive nature and exhibiting rather high diffraction efficiencies. The faster and the slower holograms are based on the excitation and diffusion of oppositely charged carriers (likely electrons and holes). Relevant parameters for the photoactive centers responsible for both kind of holograms were characterized using purely holographic techniques. No evidences of non-photosensitive ionic charge carriers being involved in the recording process at room temperature nor self-fixing effects were found.

  19. Low leakage Ru-strontium titanate-Ru metal-insulator-metal capacitors for sub-20 nm technology node in dynamic random access memory

    SciTech Connect (OSTI)

    Popovici, M. Swerts, J.; Redolfi, A.; Kaczer, B.; Aoulaiche, M.; Radu, I.; Clima, S.; Everaert, J.-L.; Van Elshocht, S.; Jurczak, M.

    2014-02-24

    Improved metal-insulator-metal capacitor (MIMCAP) stacks with strontium titanate (STO) as dielectric sandwiched between Ru as top and bottom electrode are shown. The Ru/STO/Ru stack demonstrates clearly its potential to reach sub-20 nm technology nodes for dynamic random access memory. Downscaling of the equivalent oxide thickness, leakage current density (J{sub g}) of the MIMCAPs, and physical thickness of the STO have been realized by control of the Sr/Ti ratio and grain size using a heterogeneous TiO{sub 2}/STO based nanolaminate stack deposition and a two-step crystallization anneal. Replacement of TiN with Ru as both top and bottom electrodes reduces the amount of electrically active defects and is essential to achieve a low leakage current in the MIM capacitor.

  20. Alloy inhomogeneity and carrier localization in AlGaN sections and AlGaN/AlN nanodisks in nanowires with 240350?nm emission

    SciTech Connect (OSTI)

    Himwas, C.; Hertog, M. den; Dang, Le Si; Songmuang, R.; Monroy, E.

    2014-12-15

    We present structural and optical studies of AlGaN sections and AlGaN/AlN nanodisks (NDs) in nanowires grown by plasma-assisted molecular beam epitaxy. The Al-Ga intermixing at Al(Ga)N/GaN interfaces and the chemical inhomogeneity in AlGaN NDs evidenced by scanning transmission electron microscopy are attributed to the strain relaxation process. This interpretation is supported by the three-dimensional strain distribution calculated by minimizing the elastic energy in the structure. The alloy inhomogeneity increases with the Al content, leading to enhanced carrier localization signatures in the luminescence characteristics, i.e., red shift of the emission, s-shaped temperature dependence, and linewidth broadening. Despite these effects, the emission energy of AlGaN/AlN NDs can be tuned in the 240350?nm range with internal quantum efficiencies around 30%.