National Library of Energy BETA

Sample records for mechanical problems repairs

  1. Mechanism of DNA interstrand cross-link processing by repair...

    Office of Scientific and Technical Information (OSTI)

    SciTech Connect Search Results Journal Article: Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1 Citation Details In-Document Search Title: Mechanism of ...

  2. Effect of multiple repairs in girth welds of pipelines on the mechanical properties

    SciTech Connect (OSTI)

    Vega, O.E.; Hallen, J.M.; Villagomez, A.

    2008-10-15

    This work presents the results of multiple weld repairs in the same area in seamless API X-52 microalloyed steel pipe. Four conditions of shielded metal arc welding repairs and one as-welded specimen of the girth weld were characterized to determine changes in the microstructure, grain size in the heat affected zone, and to evaluate their effect on the mechanical properties of the weld joints. The mechanical properties by means of tension tests, Charpy-V impact resistance and Vickers hardness of the welds were analyzed. The results indicate that significant changes are not generated in the microstructural constituents of the heat affected zone. Grain growth in the heat affected zone at the specimen mid-thickness with the number of repairs was observed. Tensile strength of the weld joints meets the requirement of the API 1104 standard even after the fourth weld repair. Significant reduction in Charpy-V impact resistance with the number of weld repairs was found when the notch location was in the intersection of the fusion line with the specimen mid-thickness. A significant increase in the Vickers hardness of the heat affected zone occurred after the first repair and a gradual decrease in the Vickers hardness occurred as the number of repairs increases.

  3. Quantum mechanics problems in observer's mathematics

    SciTech Connect (OSTI)

    Khots, Boris; Khots, Dmitriy

    2012-11-06

    This work considers the ontology, guiding equation, Schrodinger's equation, relation to the Born Rule, the conditional wave function of a subsystem in a setting of arithmetic, algebra and topology provided by Observer's Mathematics (see www.mathrelativity.com). Observer's Mathematics creates new arithmetic, algebra, geometry, topology, analysis and logic which do not contain the concept of continuum, but locally coincide with the standard fields. Certain results and communications pertaining to solutions of these problems are provided. In particular, we prove the following theorems: Theorem I (Two-slit interference). Let {Psi}{sub 1} be a wave from slit 1, {Psi}{sub 2} - from slit 2, and {Psi} = {Psi}{sub 1}+{Psi}{sub 2}. Then the probability of {Psi} being a wave equals to 0.5. Theorem II (k-bodies solution). For W{sub n} from m-observer point of view with m>log{sub 10}((2 Multiplication-Sign 10{sup 2n}-1){sup 2k}+1), the probability of standard expression of Hamiltonian variation is less than 1 and depends on n,m,k.

  4. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Bill Bruce; Nancy Porter; George Ritter; Matt Boring; Mark Lozev; Ian Harris; Bill Mohr; Dennis Harwig; Robin Gordon; Chris Neary; Mike Sullivan

    2005-07-20

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without

  5. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

    2004-12-31

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without

  6. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

    2004-08-17

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners

  7. Evaluation and Repair of Primary Water Stress Corrosion Cracking in Alloy 600/182 Control Rod Drive Mechanism Nozzles

    SciTech Connect (OSTI)

    Frye, Charles R.; Arey, Melvin L. Jr.; Robinson, Michael R.; Whitaker, David E.

    2002-07-01

    In February 2001, a routine visual inspection of the reactor vessel head of Oconee Nuclear Station Unit 3 identified boric acid crystals at nine of sixty-nine locations where control rod drive mechanism housings (CRDM nozzles) penetrate the head. The boric acid deposits resulted from primary coolant leaking from cracks in the nozzle attachment weld and from through-thickness cracks in the nozzle wall. A general overview of the inspection and repair process is presented and results of the metallurgical analysis are discussed in more detail. The analysis confirmed that primary water stress corrosion cracking (PWSCC) is the mechanism of failure of both the Alloy 182 weld filler material and the alloy 600 wrought base material. (authors)

  8. Repair of hydroprocessing reactors

    SciTech Connect (OSTI)

    Niccolls, E.H.; Imgram, A.G.; Bagdasarian, A.J.

    1995-12-01

    In this paper the authors very briefly review the types of damage observed and repairs performed in hydroprocessing reactors. The authors will summarize the fundamental damage mechanisms, and where in the reactors they have needed to make repairs over the years. The era from the 1960`s through about 1990 will be briefly discussed. They describe in more detail repairs undertaken in the 1990`s. Finally, they will note important technical issues their industry faces regarding repairs, and the long term reliable operation of these vessels.

  9. Low Dose Radiation-Induced Genome and Epigenome Instability Symposium and Epigenetic Mechanisms, DNA Repair, and Chromatin Symposium at the EMS 2008 Annual Meeting - October 2008

    SciTech Connect (OSTI)

    Morgan, William F.; Kovalchuk, Olga; Dolinoy, Dana C.; Dubrova, Yuri E.; Coleman, Matthew A.; Schär, Primo; Pogribny, Igor; Hendzel, Michael

    2010-02-19

    The Low Dose Radiation Symposium thoughtfully addressed ionizing radiation non-mutational but transmissable alterations in surviving cells. Deregulation of epigenetic processes has been strongly implicated in carcinogenesis, and there is increasing realization that a significant fraction of non-targeted and adaptive mechanisms in response to ionizing radiation are likely to be epigenetic in nature. Much remains to be learned about how chromatin and epigenetic regulators affect responses to low doses of radiation, and how low dose radiation impacts other epigenetic processes. The Epigenetic Mechanisms Symposium focused on on epigenetic mechanisms and their interplay with DNA repair and chromatin changes. Addressing the fact that the most well understood mediators of epigenetic regulation are histone modifications and DNA methylation. Low levels of radiation can lead to changes in the methylation status of certain gene promoters and the expression of DNA methyltransferases, However, epigenetic regulation can also involve changes in higher order chromosome structure.

  10. Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 Problem Scarcity of clean water leads to disease, death and often international tension. In many parts of the world, access to potable water is limited. The clean water supply...

  11. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; Nancy Porter; Mike Sullivan; Chris Neary

    2004-04-12

    solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) Pipe diameter sizes range from 50.8 mm (2 in.) through 1,219.2 mm (48 in.). The most common size range for 80% to 90% of operators surveyed is 508 mm to 762 mm (20 in. to 30 in.), with 95% using 558.8 mm (22 in.) pipe. An evaluation of potential repair methods clearly indicates that the project should continue to focus on the development of a repair process involving the use of GMAW welding and on the development of a repair process involving the use of fiber-reinforced composite liners.

  12. Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Tech Transfer Success Stories * 2012 Problem Optical coatings are ubiquitous, appearing on items that range from electronic devices, photographic lenses, and windows to aircraft sensors, photovoltaic cells, and lightweight plastic goggles for troops in the field. The coatings are applied to materials such as glass and ceramics, which protect or alter the way the material reflects and transmits light. However, the two main methods of applying these coatings - sputtering and chemical vapor

  13. Haier Repair Confusion Resolved | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Haier Repair Confusion Resolved Haier Repair Confusion Resolved April 26, 2010 - 12:28pm Addthis On January 7, 2010, DOE entered into a Consent Decree with Haier America regarding a problem with four models of Haier freezers that resulted in those freezers not achieving their advertised energy efficiency. DOE recently became aware that some consumers eligible for repairs were incorrectly told that they were not eligible. Haier has resolved the problem, and consumers are encouraged to contact

  14. Turbine repair process, repaired coating, and repaired turbine component

    SciTech Connect (OSTI)

    Das, Rupak; Delvaux, John McConnell; Garcia-Crespo, Andres Jose

    2015-11-03

    A turbine repair process, a repaired coating, and a repaired turbine component are disclosed. The turbine repair process includes providing a turbine component having a higher-pressure region and a lower-pressure region, introducing particles into the higher-pressure region, and at least partially repairing an opening between the higher-pressure region and the lower-pressure region with at least one of the particles to form a repaired turbine component. The repaired coating includes a silicon material, a ceramic matrix composite material, and a repaired region having the silicon material deposited on and surrounded by the ceramic matrix composite material. The repaired turbine component a ceramic matrix composite layer and a repaired region having silicon material deposited on and surrounded by the ceramic matrix composite material.

  15. Aircraft Propeller Hub Repair

    SciTech Connect (OSTI)

    Muth, Thomas R.; Peter, William H.

    2015-02-13

    The team performed a literature review, conducted residual stress measurements, performed failure analysis, and demonstrated a solid state additive manufacturing repair technique on samples removed from a scrapped propeller hub. The team evaluated multiple options for hub repair that included existing metal buildup technologies that the Federal Aviation Administration (FAA) has already embraced, such as cold spray, high velocity oxy-fuel deposition (HVOF), and plasma spray. In addition the team helped Piedmont Propulsion Systems, LLC (PPS) evaluate three potential solutions that could be deployed at different stages in the life cycle of aluminum alloy hubs, in addition to the conventional spray coating method for repair. For new hubs, a machining practice to prevent fretting with the steel drive shaft was recommended. For hubs that were refurbished with some material remaining above the minimal material condition (MMC), a silver interface applied by an electromagnetic pulse additive manufacturing method was recommended. For hubs that were at or below the MMC, a solid state additive manufacturing technique using ultrasonic welding (UW) of thin layers of 7075 aluminum to the hub interface was recommended. A cladding demonstration using the UW technique achieved mechanical bonding of the layers showing promise as a viable repair method.

  16. Coupled discrete element and finite volume solution of two classical soil mechanics problems

    SciTech Connect (OSTI)

    Chen, Feng; Drumm, Eric; Guiochon, Georges A

    2011-01-01

    One dimensional solutions for the classic critical upward seepage gradient/quick condition and the time rate of consolidation problems are obtained using coupled routines for the finite volume method (FVM) and discrete element method (DEM), and the results compared with the analytical solutions. The two phase flow in a system composed of fluid and solid is simulated with the fluid phase modeled by solving the averaged Navier-Stokes equation using the FVM and the solid phase is modeled using the DEM. A framework is described for the coupling of two open source computer codes: YADE-OpenDEM for the discrete element method and OpenFOAM for the computational fluid dynamics. The particle-fluid interaction is quantified using a semi-empirical relationship proposed by Ergun [12]. The two classical verification problems are used to explore issues encountered when using coupled flow DEM codes, namely, the appropriate time step size for both the fluid and mechanical solution processes, the choice of the viscous damping coefficient, and the number of solid particles per finite fluid volume.

  17. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Nancy Porter; Mike Sullivan; Chris Neary

    2003-05-01

    The two broad categories of deposited weld metal repair and fiber-reinforced composite repair technologies were reviewed for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Preliminary test programs were developed for both deposited weld metal repairs and for fiber-reinforced composite repair. To date, all of the experimental work pertaining to the evaluation of potential repair methods has focused on fiber-reinforced composite repairs. Hydrostatic testing was also conducted on four pipeline sections with simulated corrosion damage: two with composite liners and two without.

  18. Reputation mechanism: From resolution for truthful online auctions to the model of optimal one-gambler problem

    SciTech Connect (OSTI)

    Bradonjic, Milan

    2009-01-01

    In this paper we study reputation mechanisms, and show how the notion of reputation can help us in building truthful online auction mechanisms. From the mechanism design prospective, we derive the conditions on and design a truthful online auction mechanism. Moreover, in the case when some agents may lay or cannot have the real knowledge about the other agents reputations, we derive the resolution of the auction, such that the mechanism is truthful. Consequently, we move forward to the optimal one-gambler/one-seller problem, and explain how that problem is refinement of the previously discussed online auction design in the presence of reputation mechanism. In the setting of the optimal one-gambler problem, we naturally rise and solve the specific question: What is an agent's optimal strategy, in order to maximize his revenue? We would like to stress that our analysis goes beyond the scope, which game theory usually discusses under the notion of reputation. We model one-player games, by introducing a new parameter (reputation), which helps us in predicting the agent's behavior, in real-world situations, such as, behavior of a gambler, real-estate dealer, etc.

  19. Rapid road repair vehicle

    DOE Patents [OSTI]

    Mara, L.M.

    1998-05-05

    Disclosed is a rapid road repair vehicle capable of moving over a surface to be repaired at near normal posted traffic speeds to scan for and find at the high rate of speed, imperfections in the pavement surface, prepare the surface imperfection for repair by air pressure and vacuum cleaning, applying a correct amount of the correct patching material to effect the repair, smooth the resulting repaired surface, and catalog the location and quality of the repairs for maintenance records of the road surface. The rapid road repair vehicle can repair surface imperfections at lower cost, improved quality, at a higher rate of speed than was not heretofor possible, with significantly reduced exposure to safety and health hazards associated with this kind of road repair activities in the past. 2 figs.

  20. Rapid road repair vehicle

    DOE Patents [OSTI]

    Mara, Leo M.

    1998-01-01

    Disclosed is a rapid road repair vehicle capable of moving over a surface to be repaired at near normal posted traffic speeds to scan for and find an the high rate of speed, imperfections in the pavement surface, prepare the surface imperfection for repair by air pressure and vacuum cleaning, applying a correct amount of the correct patching material to effect the repair, smooth the resulting repaired surface, and catalog the location and quality of the repairs for maintenance records of the road surface. The rapid road repair vehicle can repair surface imperfections at lower cost, improved quality, at a higher rate of speed than was was heretofor possible, with significantly reduced exposure to safety and health hazards associated with this kind of road repair activities in the past.

  1. Class of model problems in three-body quantum mechanics that admit exact solutions

    SciTech Connect (OSTI)

    Takibayev, N. Zh.

    2008-03-15

    An approach to solving scattering problems in three-body systems for cases where the mass of one of the particles is extremely small in relation to the masses of the other two particles and where the pair potentials of interaction between the particles involved are separable is developed. Exact analytic solutions to such model problems are found for the scattering of a light particle on two fixed centers and on two interacting heavy particles. It is shown that new resonances and a dynamical resonance enhancement may appear in a three-body system.

  2. Philosophy of Mind and the Problem of FreeWill in the Light of Quantum Mechanics.

    SciTech Connect (OSTI)

    Stapp, Henry; Stapp, Henry P

    2008-04-01

    Arguments pertaining to the mind-brain connection and to the physical effectiveness of our conscious choices have been presented in two recent books, one by John Searle, the other by Jaegwon Kim. These arguments are examined, and it is argued that the difficulties encountered arise from a defective understanding and application of a pertinent part of contemporary science, namely quantum mechanics.

  3. Service and Repair Work

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    service and repair work Service and Repair Work Whenever on-site service or repair work needs to be done, a Procurement Work Sheet (PWS) must be completed, and possibly an IWS, authorized and released. PWS is required for service work even if there are no apparent hazards. PWS is required for work in Jupiter Laser Facility even if you have a PWS for service/repairs in another location. To complete a PWS for service work in Jupiter Laser Facility, please contact Sean Holte (2-3905, pager #05312).

  4. Repairable chip bonding/interconnect process

    DOE Patents [OSTI]

    Bernhardt, A.F.; Contolini, R.J.; Malba, V.; Riddle, R.A.

    1997-08-05

    A repairable, chip-to-board interconnect process which addresses cost and testability issues in the multi-chip modules is disclosed. This process can be carried out using a chip-on-sacrificial-substrate technique, involving laser processing. This process avoids the curing/solvent evolution problems encountered in prior approaches, as well is resolving prior plating problems and the requirements for fillets. For repairable high speed chip-to-board connection, transmission lines can be formed on the sides of the chip from chip bond pads, ending in a gull wing at the bottom of the chip for subsequent solder. 10 figs.

  5. Repairable chip bonding/interconnect process

    DOE Patents [OSTI]

    Bernhardt, Anthony F.; Contolini, Robert J.; Malba, Vincent; Riddle, Robert A.

    1997-01-01

    A repairable, chip-to-board interconnect process which addresses cost and testability issues in the multi-chip modules. This process can be carried out using a chip-on-sacrificial-substrate technique, involving laser processing. This process avoids the curing/solvent evolution problems encountered in prior approaches, as well is resolving prior plating problems and the requirements for fillets. For repairable high speed chip-to-board connection, transmission lines can be formed on the sides of the chip from chip bond pads, ending in a gull wing at the bottom of the chip for subsequent solder.

  6. Development of bonded composite doublers for the repair of oil recovery equipment.

    SciTech Connect (OSTI)

    Roach, David W.; Rackow, Kirk A.

    2005-06-01

    An unavoidable by-product of a metallic structure's use is the appearance of crack and corrosion flaws. Economic barriers to the replacement of these structures have created an aging infrastructure and placed even greater demands on efficient and safe repair methods. In the past decade, an advanced composite repair technology has made great strides in commercial aviation use. Extensive testing and analysis, through joint programs between the Sandia Labs FAA Airworthiness Assurance Center and the aviation industry, have proven that composite materials can be used to repair damaged aluminum structure. Successful pilot programs have produced flight performance history to establish the durability of bonded composite patches as a permanent repair on commercial aircraft structures. With this foundation in place, this effort is adapting bonded composite repair technology to civil structures. The use of bonded composite doublers has the potential to correct the difficulties associated with current repair techniques and the ability to be applied where there are no rehabilitation options. It promises to be cost-effective with minimal disruption to the users of the structure. This report concludes a study into the application of composite patches on thick steel structures typically used in mining operations. Extreme fatigue, temperature, erosive, and corrosive environments induce an array of equipment damage. The current weld repair techniques for these structures provide a fatigue life that is inferior to that of the original plate. Subsequent cracking must be revisited on a regular basis. The use of composite doublers, which do not have brittle fracture problems such as those inherent in welds, can help extend the structure's fatigue life and reduce the equipment downtime. Two of the main issues for adapting aircraft composite repairs to civil applications are developing an installation technique for carbon steel and accommodating large repairs on extremely thick structures

  7. EUVL Mask Blank Repair

    SciTech Connect (OSTI)

    Barty, A; Mirkarimi, P; Stearns, D G; Sweeney, D; Chapman, H N; Clift, M; Hector, S; Yi, M

    2002-05-22

    EUV mask blanks are fabricated by depositing a reflective Mo/Si multilayer film onto super-polished substrates. Small defects in this thin film coating can significantly alter the reflected field and introduce defects in the printed image. Ideally one would want to produce defect-free mask blanks; however, this may be very difficult to achieve in practice. One practical way to increase the yield of mask blanks is to effectively repair multilayer defects, and to this effect they present two complementary defect repair strategies for use on multilayer-coated EUVL mask blanks. A defect is any area on the mask which causes unwanted variations in EUV dose in the aerial image obtained in a printing tool, and defect repair is correspondingly defined as any strategy that renders a defect unprintable during exposure. The term defect mitigation can be adopted to describe any strategy which renders a critical defect non-critical when printed, and in this regard a non-critical defect is one that does not adversely affect device function. Defects in the patterned absorber layer consist of regions where metal, typically chrome, is unintentionally added or removed from the pattern leading to errors in the reflected field. There currently exists a mature technology based on ion beam milling and ion beam assisted deposition for repairing defects in the absorber layer of transmission lithography masks, and it is reasonable to expect that this technology will be extended to the repair of absorber defects in EUVL masks. However, techniques designed for the repair of absorber layers can not be directly applied to the repair of defects in the mask blank, and in particular the multilayer film. In this paper they present for the first time a new technique for the repair of amplitude defects as well as recent results on the repair of phase defects.

  8. Rapid road repair vehicle

    DOE Patents [OSTI]

    Mara, Leo M.

    1999-01-01

    Disclosed are improvments to a rapid road repair vehicle comprising an improved cleaning device arrangement, two dispensing arrays for filling defects more rapidly and efficiently, an array of pre-heaters to heat the road way surface in order to help the repair material better bond to the repaired surface, a means for detecting, measuring, and computing the number, location and volume of each of the detected surface imperfection, and a computer means schema for controlling the operation of the plurality of vehicle subsystems. The improved vehicle is, therefore, better able to perform its intended function of filling surface imperfections while moving over those surfaces at near normal traffic speeds.

  9. Protein Bridges DNA Base and Nucleotide Excision Repair Pathways

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protein Bridges DNA Base and Nucleotide Excision Repair Pathways Protein Bridges DNA Base and Nucleotide Excision Repair Pathways Print Wednesday, 28 October 2009 00:00 Alkyltransferase proteins (AGT) protect cells from the biological effects of DNA damage caused by the addition of alkyl groups (alkylation). Alkyltransferase-like proteins (ATLs) can do the same, but they lack the reactive cysteine residue that allows the alkyltransferase function, and the mechanism for cell protection has

  10. Open Problems, Solved Problems !

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Problems, Solved Problems and Non-Problems in DOE's Big Data Kathy Y elick Professor o f E lectrical E ngineering a nd C omputer S ciences University o f C alifornia a t B...

  11. Inspect and Repair Steam Traps

    SciTech Connect (OSTI)

    Not Available

    2006-01-01

    This revised ITP tip sheet on inspecting and repairing steam traps provide how-to advice for improving industrial steam systems using low-cost, proven practices and technologies.

  12. Motor Repair Tech Brief | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Repair Tech Brief Motor Repair Tech Brief This Tech Brief answers: Why do motors fail? When should you repair instead of replace? And how can reliability and efficiency be assured in a repair? Motor Repair Tech Brief (March 2000) (941.96 KB) More Documents & Publications Extend the Operating Life of Your Motor Service Center Evaluation Guide Premium Efficiency Motor Selection and Application Guide - A Handbook for Industry

  13. Thermosetting Polymer-Matrix Composites for Strucutral Repair Applications

    SciTech Connect (OSTI)

    William Kirby Goertzen

    2007-12-01

    Several classes of thermosetting polymer matrix composites were evaluated for use in structural repair applications. Initial work involved the characterization and evaluation of woven carbon fiber/epoxy matrix composites for structural pipeline repair. Cyanate ester resins were evaluated as a replacement for epoxy in composites for high-temperature pipe repair applications, and as the basis for adhesives for resin infusion repair of high-temperature composite materials. Carbon fiber/cyanate ester matrix composites and fumed silica/cyanate ester nanocomposites were evaluated for their thermal, mechanical, viscoelastic, and rheological properties as they relate to their structure, chemistry, and processing characteristics. The bisphenol E cyanate ester under investigation possesses a high glass transition temperature, excellent mechanical properties, and unique ambient temperature processability. The incorporate of fumed silica served to enhance the mechanical and rheological properties of the polymer and reduce thermal expansion without sacrificing glass transition or drastically altering curing kinetics. Characterization of the composites included dynamic mechanical analysis, thermomechanical analysis, differential scanning calorimetry, thermogravimetric analysis, rheological and rheokinetic evaluation, and transmission electron microscopy.

  14. Selected Bibliography on Electric Motor Repair | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Selected Bibliography on Electric Motor Repair Selected Bibliography on Electric Motor Repair The following series of repair documents related to electric motors were produced by...

  15. Communication: Practical and rigorous reduction of the many-electron quantum mechanical Coulomb problem to O(N{sup 2/3}) storage

    SciTech Connect (OSTI)

    Pederson, Mark R.

    2015-04-14

    It is tacitly accepted that, for practical basis sets consisting of N functions, solution of the two-electron Coulomb problem in quantum mechanics requires storage of O(N{sup 4}) integrals in the small N limit. For localized functions, in the large N limit, or for planewaves, due to closure, the storage can be reduced to O(N{sup 2}) integrals. Here, it is shown that the storage can be further reduced to O(N{sup 2/3}) for separable basis functions. A practical algorithm, that uses standard one-dimensional Gaussian-quadrature sums, is demonstrated. The resulting algorithm allows for the simultaneous storage, or fast reconstruction, of any two-electron Coulomb integral required for a many-electron calculation on processors with limited memory and disk space. For example, for calculations involving a basis of 9171 planewaves, the memory required to effectively store all Coulomb integrals decreases from 2.8 Gbytes to less than 2.4 Mbytes.

  16. Injection repair of carbon fiber/bismaleimide composite panels with bisphenol E cyanate ester resin

    SciTech Connect (OSTI)

    Thunga, Mahendra; Bauer, Amy; Obusek, Kristine; Meilunas, Ray; Akinc, Mufit; Kessler, Michael R

    2014-08-01

    Resin injection of bisphenol E cyanate ester, a low viscosity resin that cures into a high temperature thermoset polymer, is investigated as a reliable repair method to restore strength and stiffness in delaminated carbon fiber/bismaleimide composites used in aircraft panels. The influence of temperature on the viscosity of the uncured resin was measured to optimize the injection conditions for high resin infiltration into the delaminations. The repair efficiency of the resin was evaluated by varying the panel thickness and the method by which the delamination damage was created in the composite specimens. Ultrasonic scanning (C-scan), flash thermography images, and cross-section analysis of repaired panels revealed excellent resin infiltration into the damaged region. Evaluation of mechanical repair efficiency using both bending stiffness and in-plain compressive strength of the composite panels as the repair metrics showed values exceeding 100%.

  17. Fabrication Flaw Density and Distribution In Repairs to Reactor Pressure Vessel and Piping Welds

    SciTech Connect (OSTI)

    GJ Schuster, FA Simonen, SR Doctor

    2008-04-01

    The Pacific Northwest National Laboratory is developing a generalized fabrication flaw distribution for the population of nuclear reactor pressure vessels and for piping welds in U.S. operating reactors. The purpose of the generalized flaw distribution is to predict component-specific flaw densities. The estimates of fabrication flaws are intended for use in fracture mechanics structural integrity assessments. Structural integrity assessments, such as estimating the frequency of loss-of-coolant accidents, are performed by computer codes that require, as input, accurate estimates of flaw densities. Welds from four different reactor pressure vessels and a collection of archived pipes have been studied to develop empirical estimates of fabrication flaw densities. This report describes the fabrication flaw distribution and characterization in the repair weld metal of vessels and piping. This work indicates that large flaws occur in these repairs. These results show that repair flaws are complex in composition and sometimes include cracks on the ends of the repair cavities. Parametric analysis using an exponential fit is performed on the data. The relevance of construction records is established for describing fabrication processes and product forms. An analysis of these records shows there was a significant change in repair frequency over the years when these components were fabricated. A description of repair flaw morphology is provided with a discussion of fracture mechanics significance. Fabrication flaws in repairs are characterized using optimized-access, high-sensitivity nondestructive ultrasonic testing. Flaw characterizations are then validated by other nondestructive evaluation techniques and complemented by destructive testing.

  18. Protein Bridges DNA Base and Nucleotide Excision Repair Pathways

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protein Bridges DNA Base and Nucleotide Excision Repair Pathways Print Alkyltransferase proteins (AGT) protect cells from the biological effects of DNA damage caused by the addition of alkyl groups (alkylation). Alkyltransferase-like proteins (ATLs) can do the same, but they lack the reactive cysteine residue that allows the alkyltransferase function, and the mechanism for cell protection has remained unknown. To address this mystery, a British-American team lead by researchers at the Scripps

  19. Protein Bridges DNA Base and Nucleotide Excision Repair Pathways

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protein Bridges DNA Base and Nucleotide Excision Repair Pathways Print Alkyltransferase proteins (AGT) protect cells from the biological effects of DNA damage caused by the addition of alkyl groups (alkylation). Alkyltransferase-like proteins (ATLs) can do the same, but they lack the reactive cysteine residue that allows the alkyltransferase function, and the mechanism for cell protection has remained unknown. To address this mystery, a British-American team lead by researchers at the Scripps

  20. Protein Bridges DNA Base and Nucleotide Excision Repair Pathways

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protein Bridges DNA Base and Nucleotide Excision Repair Pathways Print Alkyltransferase proteins (AGT) protect cells from the biological effects of DNA damage caused by the addition of alkyl groups (alkylation). Alkyltransferase-like proteins (ATLs) can do the same, but they lack the reactive cysteine residue that allows the alkyltransferase function, and the mechanism for cell protection has remained unknown. To address this mystery, a British-American team lead by researchers at the Scripps

  1. IN OTHER CATEGORIES; MACHINERY; MASS BALANCE; MECHANICAL VIBRATIONS...

    Office of Scientific and Technical Information (OSTI)

    world Bracher, B. 42 ENGINEERING NOT INCLUDED IN OTHER CATEGORIES; MACHINERY; MASS BALANCE; MECHANICAL VIBRATIONS; MAINTENANCE; REPAIR Field balancing can achieve significant...

  2. Distribution System Audits, Leak Detection, and Repair: Kirtland Air Force Base Leak Detection and Repair Program

    SciTech Connect (OSTI)

    2009-01-14

    Water Best Management Practice #3 Fact Seet: Outlines how a leak detection and repair program helped Kirtland Air Force Base perform distribution system audits, leak detection, and repair to conserve water site-wide.

  3. Internal pipe attachment mechanism

    DOE Patents [OSTI]

    Bast, R.M.; Chesnut, D.A.; Henning, C.D.; Lennon, J.P.; Pastrnak, J.W.; Smith, J.A.

    1994-12-13

    An attachment mechanism is described for repairing or extending fluid carrying pipes, casings, conduits, etc. utilizing one-way motion of spring tempered fingers to provide a mechanical connection between the attachment mechanism and the pipe. The spring tempered fingers flex to permit insertion into a pipe to a desired insertion depth. The mechanical connection is accomplished by reversing the insertion motion and the mechanical leverage in the fingers forces them outwardly against the inner wall of the pipe. A seal is generated by crushing a sealing assembly by the action of setting the mechanical connection. 6 figures.

  4. Internal pipe attachment mechanism

    DOE Patents [OSTI]

    Bast, Richard M.; Chesnut, Dwayne A.; Henning, Carl D.; Lennon, Joseph P.; Pastrnak, John W.; Smith, Joseph A.

    1994-01-01

    An attachment mechanism for repairing or extending fluid carrying pipes, casings, conduits, etc. utilizing one-way motion of spring tempered fingers to provide a mechanical connection between the attachment mechanism and the pipe. The spring tempered fingers flex to permit insertion into a pipe to a desired insertion depth. The mechanical connection is accomplished by reversing the insertion motion and the mechanical leverage in the fingers forces them outwardly against the inner wall of the pipe. A seal is generated by crushing a sealing assembly by the action of setting the mechanical connection.

  5. CDK1 enhances mitochondrial bioenergetics for radiation-induced DNA repair

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Qin, Lili; Fan, Ming; Candas, Demet; Jiang, Guochun; Papadopoulos, Stelios; Tian, Lin; Woloschak, Gayle; Grdina, David J.; Li, Jian  Jian

    2015-12-06

    Nuclear DNA repair capacity is a critical determinant of cell fate under genotoxic stress conditions. DNA repair is a well-defined energy-consuming process. However, it is unclear how DNA repair is fueled and whether mitochondrial energy production contributes to nuclear DNA repair. Here, we report a dynamic enhancement of oxygen consumption and mitochondrial ATP generation in irradiated normal cells, paralleled with increased mitochondrial relocation of the cell-cycle kinase CDK1 and nuclear DNA repair. The basal and radiation-induced mitochondrial ATP generation is reduced significantly in cells harboring CDK1 phosphorylation-deficient mutant complex I subunits. Similarly, mitochondrial ATP generation and nuclear DNA repair aremore »also compromised severely in cells harboring mitochondrially targeted, kinase-deficient CDK1. These findings demonstrate a mechanism governing the communication between mitochondria and the nucleus by which CDK1 boosts mitochondrial bioenergetics to meet the increased cellular fuel demand for DNA repair and cell survival under genotoxic stress conditions.« less

  6. Inducible error-prone repair in B. subtilis. Final report, September 1, 1979-June 30, 1981

    SciTech Connect (OSTI)

    Yasbin, R. E.

    1981-06-01

    The research performed under this contract has been concentrated on the relationship between inducible DNA repair systems, mutagenesis and the competent state in the gram positive bacterium Bacillus subtilis. The following results have been obtained from this research: (1) competent Bacillus subtilis cells have been developed into a sensitive tester system for carcinogens; (2) competent B. subtilis cells have an efficient excision-repair system, however, this system will not function on bacteriophage DNA taken into the cell via the process of transfection; (3) DNA polymerase III is essential in the mechanism of the process of W-reactivation; (4) B. subtilis strains cured of their defective prophages have been isolated and are now being developed for gene cloning systems; (5) protoplasts of B. subtilis have been shown capable of acquiring DNA repair enzymes (i.e., enzyme therapy); and (6) a plasmid was characterized which enhanced inducible error-prone repair in a gram positive organism.

  7. Unmanned deepwater-line repair system passes full-scale trials

    SciTech Connect (OSTI)

    Venzi, S.; Vienna, A. )

    1993-09-06

    The first ever full-scale tests of an unmanned, deepwater-pipeline repair system were successfully conducted last year off the coast of Italy. The Italian gas-transmission company SNAM tested a submersible automatic system (SAS) sealine repair system at a depth of 600 m. The modular SAS allows sealines to be repaired by installation of the Nuovo Pignone mechanical connector. The system's trials simulated complete repair intervention on the 20-in. Trans mediterranean pipeline and provided unprecedented experience to SNAM and to the other involved in this project. The paper discusses the origin of the idea for the SAS, the design of the system, construction and testing, the first sea trials, final deep sea trials, and future developments.

  8. Known Problems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Problems Known Problems Viewing entries posted in 2001 There are no blog entries Subscribe via RSS Subscribe Browse by Date January 2016 Last edited: 2016-04-29 11:34:51

  9. Known Problems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Known Problems Known Problems No Open Issues There are currently no open issues with Euclid. Read the full post Subscribe via RSS Subscribe Browse by Date January 2016 Last edited: 2016-04-29 11:34:51

  10. INTERNAL REPAIR OF PIPELINES REVIEW & EVALUATION OF INTERNAL PIPELINE REPAIR TRIALS REPORT

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

    2004-09-01

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is generally ineffective at restoring the pressure containing capabilities of pipelines. Failure pressure for pipe repaired with carbon fiber-reinforced composite liner was greater than that of the un-repaired pipe section with damage, indicating that this type of liner is effective at restoring the pressure containing capability of pipe. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. Development of a comprehensive test plan for this process is recommended for use in the next phase of this project.

  11. Solar Water Heating System Maintenance and Repair | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Water Heating System Maintenance and Repair Solar Water Heating System Maintenance and Repair Rooftop solar water heaters need regular maintenance to operate at peak efficiency. |...

  12. Solar Water Heating System Maintenance and Repair | Department...

    Energy Savers [EERE]

    Water Heating System Maintenance and Repair Solar Water Heating System Maintenance and Repair Rooftop solar water heaters need regular maintenance to operate at peak efficiency. | ...

  13. Leveraging Service Calls and Emergency Repairs for Energy Efficiency...

    Energy Savers [EERE]

    Service Calls and Emergency Repairs for Energy Efficiency Marketing Leveraging Service Calls and Emergency Repairs for Energy Efficiency Marketing Better Buildings Residential ...

  14. Developments advance subsea pipelaying, inspection, repair

    SciTech Connect (OSTI)

    1997-09-15

    Recent advances in laying, inspecting, and repairing pipelines are helping to cut both costs and time. A new dredging system that employs jets to clear a subsea trench for pipelay received trials off Belgium last spring. Also, within the last year, projects in the Middle East and North Sea employed technologies that promise to make inspecting the surface of a subsea pipeline in difficult terrain easier, less time consuming, and therefore less costly. Plus, subsea repair of damaged pipelines may take less time with a new ``stabbable`` pipe connector. The paper describes jet dredging, inspection advance, support software, the North Sea site, and pipeline repair.

  15. Laser engineered net shaping (LENS) for the repair and modification of NWC metal components.

    SciTech Connect (OSTI)

    Atwood, Clinton J.; Smugeresky, John E. (Sandia National Labs, Livermore,CA); Gill, David Dennis

    2006-11-01

    Laser Engineered Net Shaping{trademark} (LENS{reg_sign}) is a layer additive manufacturing process that creates fully dense metal components using a laser, metal powder, and a computer solid model. This process has previously been utilized in research settings to create metal components and new material alloys. The ''Qualification of LENS for the Repair and Modification of Metal NWC Components'' project team has completed a Technology Investment project to investigate the use of LENS for repair of high rigor components. The team submitted components from four NWC sites for repair or modification using the LENS process. These components were then evaluated for their compatibility to high rigor weapons applications. The repairs included hole filling, replacement of weld lips, addition of step joints, and repair of surface flaws and gouges. The parts were evaluated for mechanical properties, corrosion resistance, weldability, and hydrogen compatibility. This document is a record of the LENS processing of each of these component types and includes process parameters, build strategies, and lessons learned. Through this project, the LENS process was shown to successfully repair or modify metal NWC components.

  16. Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hang, Bo

    2010-01-01

    DNA adducts play a central role in chemical carcinogenesis. The analysis of formation and repair of smoking-related DNA adducts remains particularly challenging as both smokers and nonsmokers exposed to smoke are repetitively under attack from complex mixtures of carcinogens such as polycyclic aromatic hydrocarbons and N -nitrosamines. The bulky DNA adducts, which usually have complex structure, are particularly important because of their biological relevance. Several known cellular DNA repair pathways have been known to operate in human cells on specific types of bulky DNA adducts, for example, nucleotide excision repair, base excision repair, and direct reversal involving O 6more » -alkylguanine DNA alkyltransferase or AlkB homologs. Understanding the mechanisms of adduct formation and repair processes is critical for the assessment of cancer risk resulting from exposure to cigarette smoke, and ultimately for developing strategies of cancer prevention. This paper highlights the recent progress made in the areas concerning formation and repair of bulky DNA adducts in the context of tobacco carcinogen-associated genotoxic and carcinogenic effects.« less

  17. A Guide to AC Motor Repair and Replacement

    SciTech Connect (OSTI)

    2004-03-01

    This booklet provides helpful information for making informed repair or replace decisions for electric motors.

  18. Electronic Fabrication & Repair | The Ames Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Electronic Fabrication & Repair The Electronics group provides custom design and fabrication of electronic equipment.. We convert ideas into custom-finished equipment in our shop using ORCAD Schematic Capture and PCB Layout software in conjunction with our PCB machine to make prototype circuit boards in-house. Our technicians also aid in automating and controlling research project instrumentation using Texas Instruments LabView. We repair all kinds of scientific and laboratory electronic and

  19. Fabrication Flaw Density and Distribution in the Repairs of Reactor Pressure Vessels

    SciTech Connect (OSTI)

    Schuster, George J.; Doctor, Steven R.; Simonen, Fredric A.

    2006-02-15

    The Pacific Northwest National Laboratory (PNNL) is developing a generalized flaw size and density distribution for the population of U.S. reactor pressure vessels (RPVs). The purpose of the generalized flaw distribution is to predict vessel specific flaw rates for use in probabilistic fracture mechanics calculations that estimate vessel failure probability. Considerable progress has been made on the construction of an engineering data base of fabrication flaws in U.S. nuclear RPVs. The fabrication processes and product forms used to construct U.S. RPVs are represented in the data base. A validation methodology has been developed for characterizing the flaws for size, shape, orientation, and composition. The relevance of construction records has been established for describing fabrication processes and product forms. The fabrication flaws were detected in material removed from cancelled nuclear power plants using high sensitivity nondestructive ultrasonic testing, and validated by other nondestructive evaluation (NDE) techniques, and complemented by destructive testing. This paper describes research that has generated data on welding flaws, which indicated that the largest flaws occur in weld repairs. Recent research results confirm that repair flaws are complex in composition and may include cracks on the repair ends. Section III of the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code for nuclear power plant components requires radiographic examinations (RT) of welds and requires repairs for RT indications that exceed code acceptable sizes. PNNL has previously obtained the complete construction records for two RPVs. Analysis of these records show a significant change in repair frequency.

  20. Model Repair Specifications for Low Voltage Induction Motors | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy Repair Specifications for Low Voltage Induction Motors Model Repair Specifications for Low Voltage Induction Motors These Model Repair Specifications are intended to cover routine repair and rewind of low-voltage random-wound three-phase AC squirrel cage induction motors. Model Repair Specifications for Low Voltage Induction Motors (November 1999) (1.31 MB) More Documents & Publications DOE Navigant Master Presentation Improving Motor and Drive System Performance - A Sourcebook

  1. DNA repair efficiency in germ cells and early mouse embryos and consequences for radiation-induced transgenerational genomic damage

    SciTech Connect (OSTI)

    Marchetti, Francesco; Wyrobek, Andrew J.

    2009-01-18

    Exposure to ionizing radiation and other environmental agents can affect the genomic integrity of germ cells and induce adverse health effects in the progeny. Efficient DNA repair during gametogenesis and the early embryonic cycles after fertilization is critical for preventing transmission of DNA damage to the progeny and relies on maternal factors stored in the egg before fertilization. The ability of the maternal repair machinery to repair DNA damage in both parental genomes in the fertilizing egg is especially crucial for the fertilizing male genome that has not experienced a DNA repair-competent cellular environment for several weeks prior to fertilization. During the DNA repair-deficient period of spermatogenesis, DNA lesions may accumulate in sperm and be carried into the egg where, if not properly repaired, could result in the formation of heritable chromosomal aberrations or mutations and associated birth defects. Studies with female mice deficient in specific DNA repair genes have shown that: (i) cell cycle checkpoints are activated in the fertilized egg by DNA damage carried by the sperm; and (ii) the maternal genotype plays a major role in determining the efficiency of repairing genomic lesions in the fertilizing sperm and directly affect the risk for abnormal reproductive outcomes. There is also growing evidence that implicates DNA damage carried by the fertilizing gamete as a mediator of postfertilization processes that contribute to genomic instability in subsequent generations. Transgenerational genomic instability most likely involves epigenetic mechanisms or error-prone DNA repair processes in the early embryo. Maternal and embryonic DNA repair processes during the early phases of mammalian embryonic development can have far reaching consequences for the genomic integrity and health of subsequent generations.

  2. Energy and Technology Review: Unlocking the mysteries of DNA repair

    SciTech Connect (OSTI)

    Quirk, W.A.

    1993-04-01

    DNA, the genetic blueprint, has the remarkable property of encoding its own repair following diverse types of structural damage induced by external agents or normal metabolism. We are studying the interplay of DNA damaging agents, repair genes, and their protein products to decipher the complex biochemical pathways that mediate such repair. Our research focuses on repair processes that correct DNA damage produced by chemical mutagens and radiation, both ionizing and ultraviolet. The most important type of DNA repair in human cells is called excision repair. This multistep process removes damaged or inappropriate pieces of DNA -- often as a string of 29 nucleotides containing the damage -- and replaces them with intact ones. We have isolated, cloned, and mapped several human repair genes associated with the nucleotide excision repair pathway and involved in the repair of DNA damage after exposure to ultraviolet light or mutagens in cooked food. We have shown that a defect in one of these repair genes, ERCC2, is responsible for the repair deficiency in one of the groups of patients with the recessive genetic disorder xeroderma pigmentosum (XP group D). We are exploring ways to purify sufficient quantities (milligrams) of the protein products of these and other repair genes so that we can understand their functions. Our long-term goals are to link defective repair proteins to human DNA repair disorders that predispose to cancer, and to produce DNA-repair-deficient mice that can serve as models for the human disorders.

  3. INTERNAL REPAIR OF GAS PIPLINES SURVEY OF OPERATOR EXPERIENCE AND INDUSTRY NEEDS REPORT

    SciTech Connect (OSTI)

    Ian D. Harris

    2003-09-01

    A repair method that can be applied from the inside of a gas transmission pipeline (i.e., a trenchless repair) is an attractive alternative to conventional repair methods since the need to excavate the pipeline is precluded. This is particularly true for pipelines in environmentally sensitive and highly populated areas. The objectives of the project are to evaluate, develop, demonstrate, and validate internal repair methods for pipelines; develop a functional specification for an internal pipeline repair system; and prepare a recommended practice for internal repair of pipelines. The purpose of this survey is to better understand the needs and performance requirements of the natural gas transmission industry regarding internal repair. A total of fifty-six surveys were sent to pipeline operators. A total of twenty completed surveys were returned, representing a 36% response rate, which is considered very good given the fact that tailored surveys are known in the marketing industry to seldom attract more than a 10% response rate. The twenty survey responses produced the following principal conclusions: (1) Use of internal weld repair is most attractive for river crossings, under other bodies of water (e.g., lakes and swamps) in difficult soil conditions, under highways, under congested intersections, and under railway crossings. All these areas tend to be very difficult and very costly if, and where, conventional excavated repairs may be currently used. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling (HDD) when a new bore must be created to solve a leak or other problem in a water/river crossing. (3) The typical travel distances required can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). In concept, these groups require pig-based systems; despooled umbilical systems could be considered for the first two groups

  4. HANFORD SITE LOW EXPOSURE PIPELINE REPAIR USING A NON-METALLIC COMPOSITE SYSTEM

    SciTech Connect (OSTI)

    HUTH RJ

    2009-11-12

    At the Department of Energy, Richland Operations (DOE-RL) Hanford site in eastern Washington, a 350 mm (14 inch) diameter high density polyethylene (HDPE) pump recirculation pipeline failed at a bonded joint adjacent to a radiologically and chemically contaminated groundwater storage basin. The responsible DOE-RL contractor, CH2MHill Plateau Remediation Company, applied a fiberglass reinforced plastic (composite) field repair system to the failed joint. The system was devised specifically for the HDPE pipe repair at the Hanford site, and had not been used on this type of plastic piping previously. This paper introduces the pipe failure scenario, describes the options considered for repair and discusses the ultimate resolution of the problem. The failed pipeline was successfully returned to service with minimal impact on waste water treatment plant operating capacity. Additionally, radiological and chemical exposures to facility personnel were maintained as low as reasonably achievable (ALARA). The repair is considered a success for the near term, and future monitoring will prove whether the repair can be considered for long term service and as a viable alternative for similar piping failures at the Hanford site.

  5. Composite vascular repair grafts via micro-imprinting and electrospinning

    SciTech Connect (OSTI)

    Liu, Yuanyuan Hu, Qingxi; Xiang, Ke Chen, Haiping Li, Yu

    2015-04-15

    Composite vascular grafts formed by micro-imprinting and electrospinning exhibited improved mechanical properties relative to those formed by electrospinning alone. The three-layered composite grafts mimic the three-layered structure of natural blood vessels. The middle layer is made by micro-imprinting poly-p-dioxanone (PPDO), while the inner and outer layers are electrospun mixtures of chitosan and polyvinyl alcohol. The graft morphology is characterized with scanning electron microscopy. For constant graft thicknesses, the PPDO increases the mechanical strength. Cells cultivated on the vascular grafts adhere and proliferate better because of the natural, biological chitosan in the inner and outer layers. Overall, the composite scaffolds could be good candidates for blood vessel repair.

  6. Alkylation damage repair in mammalian genomes

    SciTech Connect (OSTI)

    Mitra, S.; Roy, R.; Kim, N.K. |; Tano, K. |; Ibeanu, G.C. |; Dunn, W.C.; Natarajan, A.T.; Hartenstein, B.; Kaina, B.

    1992-11-01

    The repair of O{sup 6} -alkylguanine in DNA involves only O{sup 6} -methyltransferase (MGMT) while the repair of N-alkylpurines requires multiple proteins including N-methylpurine-DNA glycosylase (MPG). While the biochemical properties human and mouse MGMTs are very similar, the mouse MPG removes 7-methylguanine more efficiently than the human protein. An increased level of MGMT, without a change in the level of MPG associated with gene amplification, was observed in a mouse cell line resistant to 2-chloroethyl-N-nitrosourea. In contrast, no correlation was observed between MPG level and resistance to methyl methanesulfonate in Chinese hamster ovary (CHO) cells. This result suggests a protein other than MPG limits the repair rate of N-alkylpurine in CHO cells.

  7. Alkylation damage repair in mammalian genomes

    SciTech Connect (OSTI)

    Mitra, S.; Roy, R.; Kim, N.K. . Sealy Center for Molecular Science Oak Ridge National Lab., TN ); Tano, K. Oak Ridge National Lab., TN ); Ibeanu, G.C. Oak Ridge National Lab., TN ); Dunn, W.C. (

    1992-01-01

    The repair of O{sup 6} -alkylguanine in DNA involves only O{sup 6} -methyltransferase (MGMT) while the repair of N-alkylpurines requires multiple proteins including N-methylpurine-DNA glycosylase (MPG). While the biochemical properties human and mouse MGMTs are very similar, the mouse MPG removes 7-methylguanine more efficiently than the human protein. An increased level of MGMT, without a change in the level of MPG associated with gene amplification, was observed in a mouse cell line resistant to 2-chloroethyl-N-nitrosourea. In contrast, no correlation was observed between MPG level and resistance to methyl methanesulfonate in Chinese hamster ovary (CHO) cells. This result suggests a protein other than MPG limits the repair rate of N-alkylpurine in CHO cells.

  8. Protein Bridges DNA Base and Nucleotide Excision Repair Pathways

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... It turns out that ATL bridges two DNA repair pathways (base repair and nucleotide excision ... By mapping conservation of amino acid sequences between their ATL and sequences in other ...

  9. Solar Water Heating System Maintenance and Repair | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Water Heating System Maintenance and Repair Solar Water Heating System Maintenance and Repair May 30, 2012 - 2:35pm Addthis Rooftop solar water heaters need regular maintenance to...

  10. Selected Bibliography on Electric Motor Repair

    Office of Energy Efficiency and Renewable Energy (EERE)

    The following series of repair documents related to electric motors were produced by the U.S. Department of Energy's Advanced Manufacturing Office (formerly the Office of Industrial Technologies) with input from trade associations, consulting companies, manufacturers, non-profit operations, and others.

  11. Antibody specific for a DNA repair protein

    DOE Patents [OSTI]

    Petrini, John H.; Morgan, William Francis; Maser, Richard Scott; Carney, James Patrick

    2006-07-11

    An isolated and purified DNA molecule encoding a DNA repair protein, p95, is provided, as is isolated and purified p95. Also provided are methods of detecting p95 and DNA encoding p95. The invention further provides p95 knock-out mice.

  12. DNA encoding a DNA repair protein

    DOE Patents [OSTI]

    Petrini, John H.; Morgan, William Francis; Maser, Richard Scott; Carney, James Patrick

    2006-08-15

    An isolated and purified DNA molecule encoding a DNA repair protein, p95, is provided, as is isolated and purified p95. Also provided are methods of detecting p95 and DNA encoding p95. The invention further provides p95 knock-out mice.

  13. Inspect and Repair Steam Traps | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Inspect and Repair Steam Traps Inspect and Repair Steam Traps This tip sheet on inspecting and repairing steam traps provides how-to advice for improving industrial steam systems using low-cost, proven practices and technologies. STEAM TIP SHEET #1 Inspect and Repair Steam Traps (January 2012) (393.77 KB) More Documents & Publications Flash High-Pressure Condensate to Regenerate Low-Pressure Steam Steam Pressure Reduction: Opportunities and Issues Use Steam Jet Ejectors or Thermocompressors

  14. Component Repair Times Obtained from MSPI Data

    SciTech Connect (OSTI)

    Eide, Steven A.

    2015-05-01

    Information concerning times to repair or restore equipment to service given a failure is valuable to probabilistic risk assessments (PRAs). Examples of such uses in modern PRAs include estimation of the probability of failing to restore a failed component within a specified time period (typically tied to recovering a mitigating system before core damage occurs at nuclear power plants) and the determination of mission times for support system initiating event (SSIE) fault tree models. Information on equipment repair or restoration times applicable to PRA modeling is limited and dated for U.S. commercial nuclear power plants. However, the Mitigating Systems Performance Index (MSPI) program covering all U.S. commercial nuclear power plants provides up-to-date information on restoration times for a limited set of component types. This paper describes the MSPI program data available and analyzes the data to obtain median and mean component restoration times as well as non-restoration cumulative probability curves. The MSPI program provides guidance for monitoring both planned and unplanned outages of trains of selected mitigating systems deemed important to safety. For systems included within the MSPI program, plants monitor both train UA and component unreliability (UR) against baseline values. If the combined system UA and UR increases sufficiently above established baseline results (converted to an estimated change in core damage frequency or CDF), a “white” (or worse) indicator is generated for that system. That in turn results in increased oversight by the US Nuclear Regulatory Commission (NRC) and can impact a plant’s insurance rating. Therefore, there is pressure to return MSPI program components to service as soon as possible after a failure occurs. Three sets of unplanned outages might be used to determine the component repair durations desired in this article: all unplanned outages for the train type that includes the component of interest, only

  15. Emergency pipe line repair connects subsea pipe lines

    SciTech Connect (OSTI)

    Lerique, M.P.; Thiberge, P. ); Wright, N. )

    1990-11-01

    Emergency repair of any subsea line pipe must form a high-integrity, metal-to-metal seal. This paper presents a remote, diverless repair system that utilizes master flanges, a connector and a spool piece to repair line pipe in deep offshore waters.

  16. New Technologies for Repairing Aging Cables in Nuclear Power Plants

    SciTech Connect (OSTI)

    Simmons, Kevin L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Fifield, Leonard S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Westman, Matthew P. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2013-09-11

    The goal of this project is to demonstrate a proof-of-concept for a technique to repair aging cables that have been subjected to degradation associated with long-term thermal and radiation exposure in nuclear power plants. The physical degradation of the aging cables manifests itself primarily as cracking and increased brittleness of the polymeric electrical insulation. Therefore, the proposed cable-repair concept comprises development of techniques to impart a softening agent within the deteriorated polymer insulation jacket so as to regain the ability of the insulation to stretch without failing and possibly to heal existing cracks in the insulation. Our approach is to use commercially available ethylene-propylene rubber (EPR) as the relevant test material, demonstrate the adsorption of chemical treatments in the EPR and quantify changes in resulting physical and mechanical properties. EPR cable samples have been thermally treated in air to produce specimens corresponding to the full range of cable age-performance points from new (>350% elongation at break) to end-of-life (<50% elongation at break). The current focus is on two chemical treatments selected as candidates for restoring age-related cable elasticity loss: a rubber plasticizer and a reactive silane molecule. EPR specimens of 200, 150, 100, and 50% elongation at break have been soaked in the candidate chemical treatments and the kinetics of chemical uptake, measured by change in mass of the samples, has been determined. Mechanical properties as a function of aging and chemical treatment have been measured including ultimate tensile strength, tensile modulus at 50% strain, elongation at break, and storage modulus. Dimensional changes with treatment and changes in glass transition temperature were also investigated. These ongoing experiments are expected to provide insight into the physical-chemical nature of the effect of thermal degradation on EPR rejuvenation limits and to advance novel methods for

  17. Helium bubble distributions in reactor tank repair specimens. Part 1

    SciTech Connect (OSTI)

    Tosten, M.H.; Kestin, P.A.

    1992-03-01

    This report discusses the Reactor Tank Repair (RTR) program was initiated to develop an in-tank repair process capable of repairing stress corrosion cracks within the SRS reactor tank walls, in the event that such a repair is needed. Previous attempts to repair C-reactor tank with a gas tungsten arc (GTA) welding process were unsuccessful due to significant cracking that occurred in the heat-affected-zones adjacent to the repair welds. It was determined that this additional cracking was a result of helium embrittlement caused by the combined effects of helium (existing within the tank walls), the high heat input associated with the GTA process, and weld shrinkage stresses. Based on the results of earlier studies it was suggested that the effects of helium embrittlement could be minimized by using a low heat input GMA process. Metallographic analysis played an important role throughout the investigation of alternative welding methods for the repair of helium-containing materials.

  18. Helium bubble distributions in reactor tank repair specimens

    SciTech Connect (OSTI)

    Tosten, M.H.; Kestin, P.A.

    1992-03-01

    This report discusses the Reactor Tank Repair (RTR) program was initiated to develop an in-tank repair process capable of repairing stress corrosion cracks within the SRS reactor tank walls, in the event that such a repair is needed. Previous attempts to repair C-reactor tank with a gas tungsten arc (GTA) welding process were unsuccessful due to significant cracking that occurred in the heat-affected-zones adjacent to the repair welds. It was determined that this additional cracking was a result of helium embrittlement caused by the combined effects of helium (existing within the tank walls), the high heat input associated with the GTA process, and weld shrinkage stresses. Based on the results of earlier studies it was suggested that the effects of helium embrittlement could be minimized by using a low heat input GMA process. Metallographic analysis played an important role throughout the investigation of alternative welding methods for the repair of helium-containing materials.

  19. Approaching Problems in Particle and Nuclear Physics with Time...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Approaching Problems in Particle and Nuclear Physics with Time-Dependent Quantum Mechanics (Wednesday, Jan 20) Approaching Problems in Particle and Nuclear Physics with...

  20. Restore: Modeling Repair and Restoration Processes | Argonne National

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Laboratory Restore: Modeling Repair and Restoration Processes Restore: Modeling Repair and Restoration Processes Argonne's Restore software models complex sets of steps required to accomplish a goal, such as repairing a ruptured natural gas pipeline, when the time required to complete a step may be uncertain. For example, external conditions (i.e., the time of day, weather, and availability of crew) may affect one or more of the steps required to accomplish a goal. Therefore,

  1. Occupational Radiation Exposure During Endovascular Aortic Repair

    SciTech Connect (OSTI)

    Sailer, Anna M.; Schurink, Geert Willem H.; Bol, Martine E. Haan, Michiel W. de Zwam, Willem H. van Wildberger, Joachim E. Jeukens, Cécile R. L. P. N.

    2015-08-15

    PurposeThe aim of the study was to evaluate the radiation exposure to operating room personnel and to assess determinants for high personal doses during endovascular aortic repair.Materials and MethodsOccupational radiation exposure was prospectively evaluated during 22 infra-renal aortic repair procedures (EVAR), 11 thoracic aortic repair procedures (TEVAR), and 11 fenestrated or branched aortic repair procedures (FEVAR). Real-time over-lead dosimeters attached to the left breast pocket measured personal doses for the first operators (FO) and second operators (SO), radiology technicians (RT), scrub nurses (SN), anesthesiologists (AN), and non-sterile nurses (NSN). Besides protective apron and thyroid collar, no additional radiation shielding was used. Procedural dose area product (DAP), iodinated contrast volume, fluoroscopy time, patient’s body weight, and C-arm angulation were documented.ResultsAverage procedural FO dose was significantly higher during FEVAR (0.34 ± 0.28 mSv) compared to EVAR (0.11 ± 0.21 mSv) and TEVAR (0.06 ± 0.05 mSv; p = 0.003). Average personnel doses were 0.17 ± 0.21 mSv (FO), 0.042 ± 0.045 mSv (SO), 0.019 ± 0.042 mSv (RT), 0.017 ± 0.031 mSv (SN), 0.006 ± 0.007 mSv (AN), and 0.004 ± 0.009 mSv (NSN). SO and AN doses were strongly correlated with FO dose (p = 0.003 and p < 0.001). There was a significant correlation between FO dose and procedural DAP (R = 0.69, p < 0.001), iodinated contrast volume (R = 0.67, p < 0.001) and left-anterior C-arm projections >60° (p = 0.02), and a weak correlation with fluoroscopy time (R = 0.40, p = 0.049).ConclusionAverage FO dose was a factor four higher than SO dose. Predictors for high personal doses are procedural DAP, iodinated contrast volume, and left-anterior C-arm projections greater than 60°.

  2. Federal Facilities Maintenance, Repair Report Calls for Action

    SciTech Connect (OSTI)

    Bartlett, Rosemarie

    2012-10-01

    This article is an overview of a recent report by the Federal Facilities Council on "Predicting Outcomes from Investments in Maintenance and Repair of Federal Facilities."

  3. Advanced maintenance, inspection & repair technology for nuclear power plants

    SciTech Connect (OSTI)

    Hinton, B.M.

    1994-12-31

    Maintenance, inspection, and repair technology for nuclear power plants is outlined. The following topics are discussed: technology for reactor systems, reactor refueling bridge, fuel inspection system, fuel shuffling software, fuel reconstitution, CEA/RCCA/CRA inspection, vessel inspection capabilities, CRDM inspection and repair, reactor internals inspection and repair, stud tensioning system, stud/nut cleaning system, EDM machining technology, MI Cable systems, core exit T/C nozzle assemblies, technology for steam generators, genesis manipulator systems, ECT, UT penetrant inspections, steam generator repair and cleaning systems, technology for balance of plant, heat exchangers, piping and weld inspections, and turbogenerators.

  4. Leveraging Service Calls and Emergency Repairs for Energy Efficiency Marketing

    Broader source: Energy.gov [DOE]

    Better Buildings Residential Network Peer Exchange Call Series: Leveraging Service Calls and Emergency Repairs, Call Slides and Discussion Summary, November 13, 2014.

  5. Window Replacement, Rehabilitation, & Repair Guides- Building America Top Innovation

    Broader source: Energy.gov [DOE]

    Building America team Building Science Corporation guides contractors through several options for repairing or replacing old windows to improve air sealing and thermal performance.

  6. Computational mechanics

    SciTech Connect (OSTI)

    Goudreau, G.L.

    1993-03-01

    The Computational Mechanics thrust area sponsors research into the underlying solid, structural and fluid mechanics and heat transfer necessary for the development of state-of-the-art general purpose computational software. The scale of computational capability spans office workstations, departmental computer servers, and Cray-class supercomputers. The DYNA, NIKE, and TOPAZ codes have achieved world fame through our broad collaborators program, in addition to their strong support of on-going Lawrence Livermore National Laboratory (LLNL) programs. Several technology transfer initiatives have been based on these established codes, teaming LLNL analysts and researchers with counterparts in industry, extending code capability to specific industrial interests of casting, metalforming, and automobile crash dynamics. The next-generation solid/structural mechanics code, ParaDyn, is targeted toward massively parallel computers, which will extend performance from gigaflop to teraflop power. Our work for FY-92 is described in the following eight articles: (1) Solution Strategies: New Approaches for Strongly Nonlinear Quasistatic Problems Using DYNA3D; (2) Enhanced Enforcement of Mechanical Contact: The Method of Augmented Lagrangians; (3) ParaDyn: New Generation Solid/Structural Mechanics Codes for Massively Parallel Processors; (4) Composite Damage Modeling; (5) HYDRA: A Parallel/Vector Flow Solver for Three-Dimensional, Transient, Incompressible Viscous How; (6) Development and Testing of the TRIM3D Radiation Heat Transfer Code; (7) A Methodology for Calculating the Seismic Response of Critical Structures; and (8) Reinforced Concrete Damage Modeling.

  7. Waste minimization in an autobody repair shop

    SciTech Connect (OSTI)

    Baria, D.N.; Dorland, D.; Bergeron, J.T.

    1994-12-31

    This work was done to document the waste minimization incorporated in a new autobody repair facility in Hermantown, Minnesota. Humes Collision Center incorporated new waste reduction techniques when it expanded its old facilities in 1992 and it was able to achieve the benefits of cost reduction and waste reduction. Humes Collision Center repairs an average of 500 cars annually and is a very small quantity generator (VSQG) of hazardous waste, as defined by the Minnesota Pollution Control Agency (MPCA). The hazardous waste consists of antifreeze, batteries, paint sludge, refrigerants, and used oil, while the nonhazardous waste consists of cardboard, glass, paint filters, plastic, sanding dust, scrap metal, and wastewater. The hazardous and nonhazardous waste output were decreased by 72%. In addition, there was a 63% reduction in the operating costs. The waste minimization includes antifreeze recovery and recycling, reduction in unused waste paint, reduction, recovery and recycle of waste lacquer thinner for cleaning spray guns and paint cups, elimination of used plastic car bags, recovery and recycle of refrigerant, reduction in waste sandpaper and elimination of sanding dust, and elimination of waste paint filters. The rate of return on the investment in waste minimization equipment is estimated from 37% per year for the distillation unit, 80% for vacuum sanding, 146% for computerized paint mixing, 211% for the refrigerant recycler, to 588% per year for the gun washer. The corresponding payback time varies from 3 years to 2 months.

  8. Multiphasic survival curves for cells of human tumor cell lines: Induced repair or hypersensitive subpopulation?

    SciTech Connect (OSTI)

    Lambin, P. ||; Fertil, B.; Malaise, E.P.; Joiner, M.C.

    1994-04-01

    Survival of the cells of three human tumor cell lines of differing radiosensitivity was measured after irradiation with single doses of X rays (0.05-5 Gy). At doses below 1 Gy, cells were more radiosensitive than predicted by back-extrapolating the high-dose response. This difference was more marked for cells of the radioresistant cell lines than the radiosensitive cell line so that the {open_quotes}true{close_quotes} initial slopes of the survival curves, at very low doses, were similar for the cells of the three cell lines. This phenomenon could reflect an induced radioresistance so that low doses of X rays are more effective per gray than higher doses, because only at higher doses is there sufficient damage to trigger repair systems or other radioprotective mechanisms which can then act during the time course for repair of DNA injury. 35 refs., 2 figs.

  9. Deep patch technique for landslide repair. Final report

    SciTech Connect (OSTI)

    Helwany, B.M.

    1994-10-01

    The report describes the laboratory testing of the `USFS deep patch` technique and a CTI modification of this technique for repairing landslides with geosynthetic reinforcement. The technique involves replacing sections of roadway lost due to landslides on top of a geosynthetically-reinforced embankment. The CTI modification involves replacing the reinforced slope with a geosynthetically-reinforced retaining wall with a truncated base. Both techniques rely on the cantilevering ability of the reinforced mass to limit the load on the foundation with a high slide potential. The tests with road base showed that (1) both the USFS and CTI repair reduced effectively the adverse effects of local landsliding on the highway pavement by preventing crack propagation; (2) the USFS repair increased the stability of the repaired slope, which was in progressive failure, by reducing the stresses exerted on it; and (3) the CTI repair produced substantially greater stresses on its foundation due to the truncated base of the reinforced mass.

  10. Mechanisms of cellular transformation by carcinogenic agents

    SciTech Connect (OSTI)

    Grunberger, D.; Goff, S.P.

    1987-01-01

    This book contains 14 chapters. Some of the chapter titles are: DNA Modification by Chemical Carcinogens; Role of DNA Lesions and Repair in the Transformation of Human Cells; The Induction and Regulation of Radiogenic Transformation In Vitro: Cellular and Molecular Mechanisms; Cellular Transformation by Adenoviruses; and The fos Gene.

  11. Quantum Computing: Solving Complex Problems

    ScienceCinema (OSTI)

    DiVincenzo, David [IBM Watson Research Center

    2009-09-01

    One of the motivating ideas of quantum computation was that there could be a new kind of machine that would solve hard problems in quantum mechanics. There has been significant progress towards the experimental realization of these machines (which I will review), but there are still many questions about how such a machine could solve computational problems of interest in quantum physics. New categorizations of the complexity of computational problems have now been invented to describe quantum simulation. The bad news is that some of these problems are believed to be intractable even on a quantum computer, falling into a quantum analog of the NP class. The good news is that there are many other new classifications of tractability that may apply to several situations of physical interest.

  12. Fatigue response of repaired thick aluminum panels with bondline flaws

    SciTech Connect (OSTI)

    Conley, D.S.

    1999-03-01

    This research investigated the fatigue response of precracked 558 x 177.8 x 6.35 mm (22.0 x 7.0 x 0.25 in) 2024-T351 aluminum panels repaired with single-sided partially bonded, unidirectional, eighteen ply boron/epoxy reinforcements. Disbonds were introduced into the bondline of each repair during the adhesion process using teflon inserts. Five different disbond configurations, with varying disbond locations and sizes, were tested. Each repaired panel was subjected to constant amplitude cyclic fatigue loading with a maximum stress of 120MPa. Results from the different configurations were compared against one another and against repaired panels with no debonds to assess the effect of disbonds on repair life. Results from the experimentation showed that even in the case of very large disbonds (20% of total bond area), the bonded repairs significantly extended the lives of the cracked panels. Disbond configurations with disbonds located away from the crack in the aluminum panel, performed comparably to the repaired panel with no disbonds. Disbond configurations with disbonds covering the crack in the aluminum panel yielded slightly lower lives than those obtained from repaired panels with no disbonds. Cyclic fatigue loading caused no increase in size of the artificially induced disbonds. Cyclic disbond growth was observed in the immediate vicinity of the crack. Finite element analysis using the Three Layer Technique was performed to assess the ability of current modeling techniques in predicting the life of cracked thick aluminum panels repaired with composite patches. Results from the finite element analysis were shown to very closely match experimental data.

  13. Repairing Roofs and Ceilings: How To's for the Handy Homeowner

    SciTech Connect (OSTI)

    2006-01-01

    This brochure provides handy homeowners with tips on how to properly repair roofs and ceilings in their homes that sustained damage during a hurricane. This publications is a part of the How To's for the Handy Homeowner Series.

  14. Repairing Windows & Doors: How To's for the Handy Homeowner

    SciTech Connect (OSTI)

    2006-01-05

    This brochure contains tips for homeowners to repair windows and doors in their home that sustained hurricane damage. This publication is a part of the How To's for the Handy Homeowner Series.

  15. Repairing Walls & Floors: How To's for the Handy Homeowner

    SciTech Connect (OSTI)

    2006-01-09

    This brochure provides handy homeowners with tips on how to properly repair walls and floors in their homes that sustained damage during a hurricane. This publications is a part of the How To's for the Handy Homeowner Series.

  16. Battery, heal thyself: Inventing self-repairing batteries | Argonne...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Battery, heal thyself: Inventing self-repairing batteries By Louise Lerner * January 11, 2012 Tweet EmailPrint Imagine dropping your phone on the hard concrete sidewalk-but when...

  17. To: Mansueti, Lawrence Subject: RE: Pepco Scheduled Line Repair...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    January 29, 2007 6:28 PM To: Mansueti, Lawrence Subject: RE: Pepco Scheduled Line Repair Dec. 1-20, 2006 Larry, Regarding the planned line outage, scheduled for Feb. 20 through Mar...

  18. Intermediate hearth repair technique at Thyssen Stahl AG

    SciTech Connect (OSTI)

    Kowalski, W.; Bachhofen, H.J.; Ruether, P.; Ballewski, T.

    1996-12-31

    Nowadays various techniques for the fastest possible intermediate repair and/or emplacement of refractory materials above the tuyere level allow a significant extension of furnace campaign life. The latter are hence now exclusively determined by the service life of the hearth. The improvement of hearth monitoring and the estimation of residual brick strength of the refractory lining on the basis of temperature measurements in the hearth enable the location of individual zones of premature wear. These measurement methods, which were developed by Thyssen Stahl AG, aid the decision to undertake selective repair of the hearth. Three areas of repair are differentiated: taphole zone; hearth wall, localized; and hearth wall, extensive. This hearth repair method is described in this report using the example of hearth refurbishing blast furnace 8, Hamborn.

  19. Inspect and Repair Steam Traps - Steam Tip Sheet #1

    SciTech Connect (OSTI)

    2012-01-31

    This revised AMO tip sheet on inspecting and repairing steam traps provides how-to advice for improving industrial steam systems using low-cost, proven practices and technologies.

  20. Bearing repair services offer a cost-effective alternative to expensive replacement

    SciTech Connect (OSTI)

    2009-02-15

    The article, based on a presentation during MINExpo 2008, explains how advancement is bearing design, material, maintenance and repair methods have greatly improved the potential for and popularity of bearing repair as an effective way to extend bearing life. The Trinken Co. offers a variety of service options including repair, recertification, reconditioning and remanufacturing. Benefits of a quality repair program are outlined. 2 photos.

  1. Dofasco`s No. 4 blast furnace hearth breakout, repair and rescue

    SciTech Connect (OSTI)

    Donaldson, R.J.; Fischer, A.J.; Sharp, R.M.; Stothart, D.W.

    1995-12-01

    On May 5, 1994, after producing 9.5 million metric tons of iron, Dofasco`s No. 4 Blast Furnace experienced a hearth breakout 250 millimeters below the west taphole. The hot metal spill caused a fire resulting in severe damage and 33 days of lost production. During a 26-day period, electrical wiring, water drainage systems and both tapholes were repaired. Recovery from an unprepared furnace stop of this length, with the deadman depleted is difficult. To aid with the rescue Hoogovens-designed oxygen/fuel lances were commissioned. The furnace recovery began with a lance in each taphole and all tuyeres plugged. Six days after startup the furnace was casting into torpedo cars, and after nine days operation had returned to normal. This incident prompted Dofasco to expand the hearth monitoring system to detect and prevent similar occurrences. During the repair, 203 new thermocouples were installed in the hearth, concentrating on the tapholes and elephant foot areas. These thermocouples were installed at various depths and locations to allow heat flux calculations. This hearth monitoring system has already identified other problem areas and provided valuable information about hearth drainage patterns. This information has allowed them to develop control strategies to manage localized problem areas.

  2. Meiotic interstrand DNA damage escapes paternal repair and causes chromosomal aberrations in the zygote by maternal misrepair

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Marchetti, Francesco; Bishop, Jack; Gingerich, John; Wyrobek, Andrew J.

    2015-01-08

    De novo point mutations and chromosomal structural aberrations (CSA) detected in offspring of unaffected parents show a preferential paternal origin with higher risk for older fathers. Studies in rodents suggest that heritable mutations transmitted from the father can arise from either paternal or maternal misrepair of damaged paternal DNA, and that the entire spermatogenic cycle can be at risk after mutagenic exposure. Understanding the susceptibility and mechanisms of transmission of paternal mutations is important in family planning after chemotherapy and donor selection for assisted reproduction. We report that treatment of male mice with melphalan (MLP), a bifunctional alkylating agent widelymore » used in chemotherapy, induces DNA lesions during male mouse meiosis that persist unrepaired as germ cells progress through DNA repair-competent phases of spermatogenic development. After fertilization, unrepaired sperm DNA lesions are mis-repaired into CSA by the egg's DNA repair machinery producing chromosomally abnormal offspring. In conclusion, these findings highlight the importance of both pre- and post-fertilization DNA repair in assuring the genomic integrity of the conceptus.« less

  3. Cadmium sulfate and CdTe-quantum dots alter DNA repair in zebrafish (Danio rerio) liver cells

    SciTech Connect (OSTI)

    Tang, Song; Cai, Qingsong; Chibli, Hicham; Allagadda, Vinay; Nadeau, Jay L.; Mayer, Gregory D.

    2013-10-15

    Increasing use of quantum dots (QDs) makes it necessary to evaluate their toxicological impacts on aquatic organisms, since their contamination of surface water is inevitable. This study compares the genotoxic effects of ionic Cd versus CdTe nanocrystals in zebrafish hepatocytes. After 24 h of CdSO{sub 4} or CdTe QD exposure, zebrafish liver (ZFL) cells showed a decreased number of viable cells, an accumulation of Cd, an increased formation of reactive oxygen species (ROS), and an induction of DNA strand breaks. Measured levels of stress defense and DNA repair genes were elevated in both cases. However, removal of bulky DNA adducts by nucleotide excision repair (NER) was inhibited with CdSO{sub 4} but not with CdTe QDs. The adverse effects caused by acute exposure of CdTe QDs might be mediated through differing mechanisms than those resulting from ionic cadmium toxicity, and studying the effects of metallic components may be not enough to explain QD toxicities in aquatic organisms. - Highlights: Both CdSO{sub 4} and CdTe QDs lead to cell death and Cd accumulation. Both CdSO{sub 4} and CdTe QDs induce cellular ROS generation and DNA strand breaks. Both CdSO{sub 4} and CdTe QDs induce the expressions of stress defense and DNA repair genes. NER repair capacity was inhibited with CdSO{sub 4} but not with CdTe QDs.

  4. Exposure Evaluation for Benzene, Lead and Noise in Vehicle and Equipment Repair Shops

    SciTech Connect (OSTI)

    Sweeney, Lynn C.

    2013-04-01

    An exposure assessment was performed at the equipment and vehicle maintenance repair shops operating at the U. S. Department of Energy Hanford site, in Richland, Washington. The maintenance shops repair and maintain vehicles and equipment used in support of the Hanford cleanup mission. There are three general mechanic shops and one auto body repair shop. The mechanics work on heavy equipment used in construction, cranes, commercial motor vehicles, passenger-type vehicles in addition to air compressors, generators, and farm equipment. Services include part fabrication, installation of equipment, repair and maintenance work in the engine compartment, and tire and brake services. Work performed at the auto body shop includes painting and surface preparation which involves applying body filler and sanding. 8-hour time-weighted-average samples were collected for benzene and noise exposure and task-based samples were collected for lead dust work activities involving painted metal surfaces. Benzene samples were obtained using 3M™ 3520 sampling badges and were analyzed for additional volatile organic compounds. These compounds were selected based on material safety data sheet information for the aerosol products used by the mechanics for each day of sampling. The compounds included acetone, ethyl ether, toluene, xylene, VM&P naphtha, methyl ethyl ketone, and trichloroethylene. Laboratory data for benzene, VM&P naphtha, methyl ethyl ketone and trichloroethylene were all below the reporting detection limit. Airborne concentrations for acetone, ethyl ether, toluene and xylene were all less than 10% of their occupational exposure limit. The task-based samples obtained for lead dusts were submitted for a metal scan analysis to identify other metals that might be present. Laboratory results for lead dusts were all below the reporting detection limit and airborne concentration for the other metals observed in the samples were less than 10% of the occupational exposure limit

  5. Microfabricated therapeutic actuator mechanisms

    DOE Patents [OSTI]

    Northrup, M.A.; Ciarlo, D.R.; Lee, A.P.; Krulevitch, P.A.

    1997-07-08

    Electromechanical microstructures (microgrippers), either integrated circuit (IC) silicon-based or precision machined, to extend and improve the application of catheter-based interventional therapies for the repair of aneurysms in the brain or other interventional clinical therapies. These micromechanisms can be specifically applied to release platinum coils or other materials into bulging portions of the blood vessels also known as aneurysms. The ``micro`` size of the release mechanism is necessary since the brain vessels are the smallest in the body. Through a catheter more than one meter long, the micromechanism located at one end of the catheter can be manipulated from the other end thereof. The microgripper (micromechanism) of the invention will also find applications in non-medical areas where a remotely actuated microgripper or similar actuator would be useful or where micro-assembling is needed. 22 figs.

  6. Microfabricated therapeutic actuator mechanisms

    DOE Patents [OSTI]

    Northrup, Milton A.; Ciarlo, Dino R.; Lee, Abraham P.; Krulevitch, Peter A.

    1997-01-01

    Electromechanical microstructures (microgrippers), either integrated circuit (IC) silicon-based or precision machined, to extend and improve the application of catheter-based interventional therapies for the repair of aneurysms in the brain or other interventional clinical therapies. These micromechanisms can be specifically applied to release platinum coils or other materials into bulging portions of the blood vessels also known as aneurysms. The "micro" size of the release mechanism is necessary since the brain vessels are the smallest in the body. Through a catheter more than one meter long, the micromechanism located at one end of the catheter can be manipulated from the other end thereof. The microgripper (micromechanism) of the invention will also find applications in non-medical areas where a remotely actuated microgripper or similar actuator would be useful or where micro-assembling is needed.

  7. LENS repair and modification of metal NW components:materials and applications guide.

    SciTech Connect (OSTI)

    Smugeresky, John E. (Sandia National Laboratories, Livermore, CA); Gill, David Dennis; Oberhaus, Jason (BWXT Y-12); Adams, Thad; VanCamp, Chad

    2006-11-01

    Laser Engineered Net Shaping{trademark} (LENS{reg_sign}) is a unique, layer additive, metal manufacturing technique that offers the ability to create fully dense metal features and components directly from a computer solid model. LENS offers opportunities to repair and modify components by adding features to existing geometry, refilling holes, repairing weld lips, and many other potential applications. The material deposited has good mechanical properties with strengths typically slightly higher that wrought material due to grain refinement from a quickly cooling weld pool. The result is a material with properties similar to cold worked material, but without the loss in ductility traditionally seen with such treatments. Furthermore, 304L LENS material exhibits good corrosion resistance and hydrogen compatibility. This report gives a background of the LENS process including materials analysis addressing the requirements of a number of different applications. Suggestions are given to aid both the product engineer and the process engineer in the successful utilization of LENS for their applications. The results of testing on interface strength, machinability, weldability, corrosion resistance, geometric effects, heat treatment, and repair strategy testing are all included. Finally, the qualification of the LENS process is briefly discussed to give the user confidence in selecting LENS as the process of choice for high rigor applications. The testing showed LENS components to have capability in repair/modification applications requiring complex castings (W80-3 D-Bottle bracket), thin wall parts requiring metal to be rebuilt onto the part (W87 Firing Set Housing and Y-12 Test Rings), the filling of counterbores for use in reservoir reclamation welding (SRNL hydrogen compatibility study) and the repair of surface defects on pressure vessels (SRNL gas bottle repair). The material is machinable, as testing has shown that LENS deposited material machines similar to that of

  8. Chemical repair of base lesions, AP-sites, and strand breaks on plasmid DNA in dilute aqueous solution by ascorbic acid

    SciTech Connect (OSTI)

    Hata, Kuniki; Advanced Science Research Center, Japan Atomic Energy Agency, 2-4 Shirakatashirane, Tokai-mura, Naka-gun, Ibaraki 319-1195 ; Urushibara, Ayumi; Yamashita, Shinichi; Shikazono, Naoya; Yokoya, Akinari; Katsumura, Yosuke; Nuclear Professional School, School of Engineering, The University of Tokyo, 2-22 Shirakatashirane, Tokai-mura, Naka-gun, Ibaraki 319-1188

    2013-05-03

    Highlights: We report a novel mechanism of radiation protection of DNA by chemical activity of ascorbic acid. The chemical repair of DNA damage was revealed using biochemical assay and chemical kinetics analysis. We found that ascorbic acid significantly repairs precursors of nucleobase lesions and abasic sites. However, ascorbic acid seldom repairs precursors of DNA-strand breaks. -- Abstract: We quantified the damage yields produced in plasmid DNA by ?-irradiation in the presence of low concentrations (10100 ?M) of ascorbic acid, which is a major antioxidant in living systems, to clarify whether it chemically repairs radiation damage in DNA. The yield of DNA single strand breaks induced by irradiation was analyzed with agarose gel electrophoresis as conformational changes in closed circular plasmids. Base lesions and abasic sites were also observed as additional conformational changes by treating irradiated samples with glycosylase proteins. By comparing the suppression efficiencies to the induction of each DNA lesion, in addition to scavenging of the OH radicals derived from water radiolysis, it was found that ascorbic acid promotes the chemical repair of precursors of AP-sites and base lesions more effectively than those of single strand breaks. We estimated the efficiency of the chemical repair of each lesion using a kinetic model. Approximately 5060% of base lesions and AP-sites were repaired by 10 ?M ascorbic acid, although strand breaks were largely unrepaired by ascorbic acid at low concentrations. The methods in this study will provide a route to understanding the mechanistic aspects of antioxidant activity in living systems.

  9. Ice plug employed on subsea pipeline bend during repair

    SciTech Connect (OSTI)

    1997-12-22

    The first controlled-temperature ice plug in the bend of an offshore gas trunkline has been carried out for Phillips Petroleum Co. Norway on its Norpipe A.S. platform in the German sector of the North Sea. The procedure was part of a subsea valve repair operation. The ice plug was successfully formed offshore and tested to a differential pressure of 1,450 psi. Repair of two valves required only 5 days during which time gas production was operating at close to 50--60% via the platform bypass, says the service company. The paper discusses the procedure.

  10. Patient Compliance with Surveillance Following Elective Endovascular Aneurysm Repair

    SciTech Connect (OSTI)

    Godfrey, Anthony D. Morbi, Abigail H. M. Nordon, Ian M.

    2015-10-15

    PurposeIntegral to maintaining good outcomes post-endovascular aneurysm repair (EVAR) is a robust surveillance protocol. A significant proportion of patients fail to comply with surveillance, exposing themselves to complications. We examine EVAR surveillance in Wessex (UK), exploring factors that may predict poor compliance.MethodsRetrospective analysis of 179 consecutive elective EVAR cases [2008–2013] was performed. 167 patients were male, with the age range of 50–95. Surveillance was conducted centrally (tertiary referral trauma centre) and at four spoke units. Surveillance compliance and predictors of non-compliance including age, gender, co-morbid status, residential location and socioeconomic status were analysed for univariate significance.ResultsFifty patients (27.9 %) were non-compliant with surveillance; 14 (8.1 %) had no imaging post-EVAR. At 1 year, 56.1 % (of 123 patients) were compliant. At years 2 and 3, 41.5 and 41.2 % (of 65 and 34 patients, respectively) were compliant. Four years post-EVAR, only one of eight attended surveillance (12.5 %). There were no statistically significant differences in age (p = 0.77), co-morbid status or gender (p = 0.64). Distance to central unit (p = 0.67) and surveillance site (p = 0.56) was non-significant. While there was a trend towards compliance in upper-middle-class socioeconomic groups (ABC1 vs. C1C2D), correlating with >50 % of non-compliant patients living within <10 mile radius of the central unit, overall predictive value was not significant (p = 0.82).ConclusionsCompliance with surveillance post-EVAR is poor. No independent predictor of non-compliance has been confirmed, but socioeconomic status appears to be relevant. There is a worrying drop-off in attendance beyond the first year. This study highlights a problem that needs to be addressed urgently, if we are to maintain good outcomes post-EVAR.

  11. Methods to alter levels of a DNA repair protein

    DOE Patents [OSTI]

    Petrini, John H.; Morgan, William Francis; Maser, Richard Scott; Carney, James Patrick

    2006-10-17

    An isolated and purified DNA molecule encoding a DNA repair protein, p95, is provided, as is isolated and purified p95. Also provided are methods of detecting p95 and DNA encoding p95. The invention further provides p95 knock-out mice.

  12. Development of quick repairing technique for ceramic burner in hot stove of blast furnace

    SciTech Connect (OSTI)

    Kondo, Atsushi; Doura, Kouji; Nakamura, Hirofumi

    1997-12-31

    Refractories of ceramic burner in hot stoves at Wakayama No. 4 blast furnace were damaged. There are only three hot stoves, so repairing must be done in a short. Therefore, a quick repairing technique for ceramic burners has been developed, and two ceramic burners were repaired in just 48 hours.

  13. Final Report for DOE Grant DE-FG02-03ER25579; Development of High-Order Accurate Interface Tracking Algorithms and Improved Constitutive Models for Problems in Continuum Mechanics with Applications to Jetting

    SciTech Connect (OSTI)

    Puckett, Elbridge Gerry; Miller, Gregory Hale

    2012-10-14

    Much of the work conducted under the auspices of DE-FG02-03ER25579 was characterized by an exceptionally close collaboration with researchers at the Lawrence Berkeley National Laboratory (LBNL). For example, Andy Nonaka, one of Professor Miller's graduate students in the Department of Applied Science at U. C. Davis (UCD) wrote his PhD thesis in an area of interest to researchers in the Applied Numerical Algorithms Group (ANAG), which is a part of the National Energy Research Supercomputer Center (NERSC) at LBNL. Dr. Nonaka collaborated closely with these researchers and subsequently published the results of this collaboration jointly with them, one article in a peer reviewed journal article and one paper in the proceedings of a conference. Dr. Nonaka is now a research scientist in the Center for Computational Sciences and Engineering (CCSE), which is also part of the National Energy Research Supercomputer Center (NERSC) at LBNL. This collaboration with researchers at LBNL also included having one of Professor Puckett's graduate students in the Graduate Group in Applied Mathematics (GGAM) at UCD, Sarah Williams, spend the summer working with Dr. Ann Almgren, who is a staff scientist in CCSE. As a result of this visit Sarah decided work on a problem suggested by the head of CCSE, Dr. John Bell, for her PhD thesis. Having finished all of the coursework and examinations required for a PhD, Sarah stayed at LBNL to work on her thesis under the guidance of Dr. Bell. Sarah finished her PhD thesis in June of 2007. Writing a PhD thesis while working at one of the University of California (UC) managed DOE laboratories is long established tradition at UC and Professor Puckett has always encouraged his students to consider doing this. Another one of Professor Puckett's graduate students in the GGAM at UCD, Christopher Algieri, was partially supported with funds from DE-FG02-03ER25579 while he wrote his MS thesis in which he analyzed and extended work originally published by Dr

  14. The Guderley problem revisited

    SciTech Connect (OSTI)

    Ramsey, Scott D [Los Alamos National Laboratory; Kamm, James R [Los Alamos National Laboratory; Bolstad, John H [NON LANL

    2009-01-01

    The self-similar converging-diverging shock wave problem introduced by Guderley in 1942 has been the source of numerous investigations since its publication. In this paper, we review the simplifications and group invariance properties that lead to a self-similar formulation of this problem from the compressible flow equations for a polytropic gas. The complete solution to the self-similar problem reduces to two coupled nonlinear eigenvalue problems: the eigenvalue of the first is the so-called similarity exponent for the converging flow, and that of the second is a trajectory multiplier for the diverging regime. We provide a clear exposition concerning the reflected shock configuration. Additionally, we introduce a new approximation for the similarity exponent, which we compare with other estimates and numerically computed values. Lastly, we use the Guderley problem as the basis of a quantitative verification analysis of a cell-centered, finite volume, Eulerian compressible flow algorithm.

  15. Radiation-Induced Upregulation of Gene Expression From Adenoviral Vectors Mediated by DNA Damage Repair and Regulation

    SciTech Connect (OSTI)

    Nokisalmi, Petri; Rajecki, Maria; Pesonen, Sari; Escutenaire, Sophie; Soliymani, Rabah; Tenhunen, Mikko; Ahtiainen, Laura; Hemminki, Akseli

    2012-05-01

    Purpose: In the present study, we evaluated the combination of replication-deficient adenoviruses and radiotherapy in vitro. The purpose of the present study was to analyze the mechanism of radiation-mediated upregulation of adenoviral transgene expression. Methods and Materials: Adenoviral transgene expression (luciferase or green fluorescent protein) was studied with and without radiation in three cell lines: breast cancer M4A4-LM3, prostate cancer PC-3MM2, and lung cancer LNM35/enhanced green fluorescent protein. The effect of the radiation dose, modification of the viral capsid, and five different transgene promoters were studied. The cellular responses were studied using mass spectrometry and immunofluorescence analysis. Double strand break repair was modulated by inhibitors of heat shock protein 90, topoisomerase-I, and DNA protein kinase, and transgene expression was measured. Results: We found that a wide range of radiation doses increased adenoviral transgene expression regardless of the cell line, transgene, promoter, or viral capsid modification. Treatment with adenovirus, radiation, and double strand break repair inhibitors resulted in persistence of double strand breaks and subsequent increases in adenovirus transgene expression. Conclusions: Radiation-induced enhancement of adenoviral transgene expression is linked to DNA damage recognition and repair. Radiation induces a global cellular response that results in increased production of RNA and proteins, including adenoviral transgene products. This study provides a mechanistic rationale for combining radiation with adenoviral gene delivery.

  16. Sandia National Laboratories Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Problem Natural disasters such as Hurricane Katrina in New Orleans and the tsunami in Japan in 2011 create emergency situations that must be dealt with quickly and effectively in...

  17. Cycling with BRCA2 from DNA repair to mitosis

    SciTech Connect (OSTI)

    Lee, Hyunsook

    2014-11-15

    Genetic integrity in proliferating cells is guaranteed by the harmony of DNA replication, appropriate DNA repair, and segregation of the duplicated genome. Breast cancer susceptibility gene BRCA2 is a unique tumor suppressor that is involved in all three processes. Hence, it is critical in genome maintenance. The functions of BRCA2 in DNA repair and homology-directed recombination (HDR) have been reviewed numerous times. Here, I will briefly go through the functions of BRCA2 in HDR and focus on the emerging roles of BRCA2 in telomere homeostasis and mitosis, then discuss how BRCA2 exerts distinct functions in a cell-cycle specific manner in the maintenance of genomic integrity. - Highlights: • BRCA2 is a multifaceted tumor suppressor and is crucial in genetic integrity. • BRCA2 exerts distinct functions in cell cycle-specific manner. • Mitotic kinases regulate diverse functions of BRCA2 in mitosis and cytokinesis.

  18. Thermostatic/orifice trap reduces fuel, repair costs

    SciTech Connect (OSTI)

    Not Available

    1982-11-01

    This article is an evaluation of a steam trap that combines the continuous drain oriface with a thermostatically controlled trap oriface to efficiently remove condensate from virtually any steam system within its operating limits. This trap effectively reduces fuel and repair costs and has a capacity of 6000 il/hr, handles various pressures up to 600 psig, and operates against back pressures up to 90% of inlet pressure.

  19. FABRICATION AND REPAIR OF ION SOURCE COMPONENTS IN THE 80 keV NEUTRAL BEAM LINES FOR DIII-D

    SciTech Connect (OSTI)

    GRUNLOH,H.J; BUSATH,J.L; CALLIS,R.W; CHIU,H.K; DiMARTINO,M; HONG,R; KLASEN,R; MOELLER,C.P; ROBINSON,J.I; STRECKERT,H.H; TAO,R; TRESTER,P.W

    2003-10-01

    OAK-B135 After 8 years of operation, leaks began to develop in critical components of the ion sources of the 80 keV neutral beam lines in DIII-D. Operational adjustments were made that seemed to remedy the problems, but five years later leaks began occurring again, this time with greater frequency. Failures occurred in the stainless steel bellows and molybdenum rails of the grid rail modules as well as in the Langmuir probes. Failure analyses identified several root causes of the leaks and operational adjustments were again made to mitigate the problems, but the rash of failures depleted the program's supply of spare grid rail modules and probes and removed one of the ion sources from regular operation. Fifteen years after their original fabrication, the ion source components were no longer commercially available. In 2001, a program was initiated to fabricate new grid rail modules, including new molybdenum grid rails, bellows, and stainless steel grid rail holders, as well as new Langmuir probes. In parallel, components removed from service due to leaks were to be repaired with new rails and bellows and returned to service. An overview of the root causes of the service failures is offered, details of the repair processes are described, and a summary and evaluation of the fabrication procedures for the new molybdenum rails, grid modules, and Langmuir probes are given.

  20. Statistical mechanics based on fractional classical and quantum mechanics

    SciTech Connect (OSTI)

    Korichi, Z.; Meftah, M. T.

    2014-03-15

    The purpose of this work is to study some problems in statistical mechanics based on the fractional classical and quantum mechanics. At first stage we have presented the thermodynamical properties of the classical ideal gas and the system of N classical oscillators. In both cases, the Hamiltonian contains fractional exponents of the phase space (position and momentum). At the second stage, in the context of the fractional quantum mechanics, we have calculated the thermodynamical properties for the black body radiation, studied the Bose-Einstein statistics with the related problem of the condensation and the Fermi-Dirac statistics.

  1. Bicriteria network design problems

    SciTech Connect (OSTI)

    Marathe, M.V.; Ravi, R.; Sundaram, R.; Ravi, S.S.; Rosenkrantz, D.J.; Hunt, H.B. III

    1997-11-20

    The authors study a general class of bicriteria network design problems. A generic problem in this class is as follows: Given an undirected graph and two minimization objectives (under different cost functions), with a budget specified on the first, find a subgraph from a given subgraph class that minimizes the second objective subject to the budget on the first. They consider three different criteria -- the total edge cost, the diameter and the maximum degree of the network. Here, they present the first polynomial-time approximation algorithms for a large class of bicriteria network design problems for the above mentioned criteria. The following general types of results are presented. First, they develop a framework for bicriteria problems and their approximations. Second, when the two criteria are the same they present a black box parametric search technique. This black box takes in as input an (approximation) algorithm for the criterion situation and generates an approximation algorithm for the bicriteria case with only a constant factor loss in the performance guarantee. Third, when the two criteria are the diameter and the total edge costs they use a cluster based approach to devise approximation algorithms. The solutions violate both the criteria by a logarithmic factor. Finally, for the class of treewidth-bounded graphs, they provide pseudopolynomial-time algorithms for a number of bicriteria problems using dynamic programming. The authors show how these pseudopolynomial-time algorithms can be converted to fully polynomial-time approximation schemes using a scaling technique.

  2. Dynamical impurity problems

    SciTech Connect (OSTI)

    Emery, V.J.; Kivelson, S.A.

    1993-12-31

    In the past few years there has been a resurgence of interest in dynamical impurity problems, as a result of developments in the theory of correlated electron systems. The general dynamical impurity problem is a set of conduction electrons interacting with an impurity which has internal degrees of freedom. The simplest and earliest example, the Kondo problem, has attracted interest since the mid-sixties not only because of its physical importance but also as an example of a model displaying logarithmic divergences order by order in perturbation theory. It provided one of the earliest applications of the renormalization group method, which is designed to deal with just such a situation. As we shall see, the antiferromagnetic Kondo model is controlled by a strong-coupling fixed point, and the essence of the renormalization group solution is to carry out the global renormalization numerically starting from the original (weak-coupling) Hamiltonian. In these lectures, we shall describe an alternative route in which we identify an exactly solvable model which renormalizes to the same fixed point as the original dynamical impurity problem. This approach is akin to determining the critical behavior at a second order phase transition point by solving any model in a given universality class.

  3. Blade reliability collaborative : collection of defect, damage and repair data.

    SciTech Connect (OSTI)

    Ashwill, Thomas D.; Ogilvie, Alistair B.; Paquette, Joshua A.

    2013-04-01

    The Blade Reliability Collaborative (BRC) was started by the Wind Energy Technologies Department of Sandia National Laboratories and DOE in 2010 with the goal of gaining insight into planned and unplanned O&M issues associated with wind turbine blades. A significant part of BRC is the Blade Defect, Damage and Repair Survey task, which will gather data from blade manufacturers, service companies, operators and prior studies to determine details about the largest sources of blade unreliability. This report summarizes the initial findings from this work.

  4. Economic penalties of problems and errors in solar energy systems

    SciTech Connect (OSTI)

    Raman, K.; Sparkes, H.R.

    1983-01-01

    Experience with a large number of installed solar energy systems in the HUD Solar Program has shown that a variety of problems and design/installation errors have occurred in many solar systems, sometimes resulting in substantial additional costs for repair and/or replacement. In this paper, the effect of problems and errors on the economics of solar energy systems is examined. A method is outlined for doing this in terms of selected economic indicators. The method is illustrated by a simple example of a residential solar DHW system. An example of an installed, instrumented solar energy system in the HUD Solar Program is then discussed. Detailed results are given for the effects of the problems and errors on the cash flow, cost of delivered heat, discounted payback period, and life-cycle cost of the solar energy system. Conclusions are drawn regarding the most suitable economic indicators for showing the effects of problems and errors in solar energy systems. A method is outlined for deciding on the maximum justifiable expenditure for maintenance on a solar energy system with problems or errors.

  5. The inhibiting bisection problem.

    SciTech Connect (OSTI)

    Pinar, Ali

    2010-11-01

    Given a graph where each vertex is assigned a generation or consumption volume, we try to bisect the graph so that each part has a significant generation/consumption mismatch, and the cutsize of the bisection is small. Our motivation comes from the vulnerability analysis of distribution systems such as the electric power system. We show that the constrained version of the problem, where we place either the cutsize or the mismatch significance as a constraint and optimize the other, is NP-complete, and provide an integer programming formulation. We also propose an alternative relaxed formulation, which can trade-off between the two objectives and show that the alternative formulation of the problem can be solved in polynomial time by a maximum flow solver. Our experiments with benchmark electric power systems validate the effectiveness of our methods.

  6. Building America Top Innovations 2013 Profile – Window Replacement, Rehabilitation, & Repair Guide

    SciTech Connect (OSTI)

    none,

    2013-09-01

    In this Top Innovation profile, Building Science Corporation guides contractors through several options for repairing or replacing old windows to improve air sealing and thermal performance.

  7. One "Cool Tool" That's Helping Repair Your DNA | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    "Cool Tool" That's Helping Repair Your DNA One "Cool Tool" That's Helping Repair Your DNA April 18, 2011 - 1:20pm Addthis Charles Rousseaux Charles Rousseaux Senior Communications Specialist (detailee) What are the key facts? Berkeley Lab's Advanced Light Source produces x-ray light that shines a billion times bright than the sun. Scientists discovered the motor that drives the actual repair of the DNA repair machine called MRN, which is tethered to the rest of the machine in

  8. adaptation of DNA repair Byrne, Rose T; Klingele, Audrey J; Cabot...

    Office of Scientific and Technical Information (OSTI)

    Evolution of extreme resistance to ionizing radiation via genetic adaptation of DNA repair Byrne, Rose T; Klingele, Audrey J; Cabot, Eric L; Schackwitz, Wendy S; Martin, Jeffrey A;...

  9. WPN 12-9: Weatherization Assistance Program Incidental Repair Measure Guidance

    Broader source: Energy.gov [DOE]

    To provide guidance on incidental repair measures (IRM) allowable under the U.S. Department of Energy Weatherization Assistance Program (WAP).

  10. Brain necrosis after fractionated radiation therapy: Is the halftime for repair longer than we thought?

    SciTech Connect (OSTI)

    Bender, Edward T.

    2012-11-15

    Purpose: To derive a radiobiological model that enables the estimation of brain necrosis and spinal cord myelopathy rates for a variety of fractionation schemes, and to compare repair effects between brain and spinal cord. Methods: Sigmoidal dose response relationships for brain radiation necrosis and spinal cord myelopathy are derived from clinical data using nonlinear regression. Three different repair models are considered and the repair halftimes are included as regression parameters. Results: For radiation necrosis, a repair halftime of 38.1 (range 6.9-76) h is found with monoexponential repair, while for spinal cord myelopathy, a repair halftime of 4.1 (range 0-8) h is found. The best-fit alpha beta ratio is 0.96 (range 0.24-1.73)Conclusions: A radiobiological model that includes repair corrections can describe the clinical data for a variety of fraction sizes, fractionation schedules, and total doses. Modeling suggests a relatively long repair halftime for brain necrosis. This study suggests that the repair halftime for late radiation effects in the brain may be longer than is currently thought. If confirmed in future studies, this may lead to a re-evaluation of radiation fractionation schedules for some CNS diseases, particularly for those diseases where fractionated stereotactic radiation therapy is used.

  11. Best Management Practice #3: Distribution System Audits, Leak Detection, and Repair

    Broader source: Energy.gov [DOE]

    A distribution system audit, or leak detection and repair program, may help federal facilities identify and reduce water losses and be better stewards of water as a resource.

  12. Sandia National Laboratories Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sandia National Laboratories Problem Natural disasters such as Hurricane Katrina in New Orleans and the tsunami in Japan in 2011 create emergency situations that must be dealt with quickly and effectively in order to minimize injury and loss of life. Simulating such events before they occur can help emergency responders fine-tune their preparations. To create the most accurate modeling scenarios, exercise planners need to know critical details of the event, such as infrastructure damage and

  13. GRAND CHALLENGE PROBLEMS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GRAND CHALLENGE PROBLEMS Time is the biggest issue. Materials typically become critical in a matter of months, but solutions take years or decades to develop and implement. Our first two grand challenges address this discrepancy. Anticipating Which Materials May Go Critical In an ideal world, users of materials would anticipate supply-chain disruptions before they occur. They would undertake activities to manage the risks of disruption, including R&D to diversify and increase supplies or to

  14. Mechanical memory

    DOE Patents [OSTI]

    Gilkey, Jeffrey C.; Duesterhaus, Michelle A.; Peter, Frank J.; Renn, Rosemarie A.; Baker, Michael S.

    2006-08-15

    A first-in-first-out (FIFO) microelectromechanical memory apparatus (also termed a mechanical memory) is disclosed. The mechanical memory utilizes a plurality of memory cells, with each memory cell having a beam which can be bowed in either of two directions of curvature to indicate two different logic states for that memory cell. The memory cells can be arranged around a wheel which operates as a clocking actuator to serially shift data from one memory cell to the next. The mechanical memory can be formed using conventional surface micromachining, and can be formed as either a nonvolatile memory or as a volatile memory.

  15. Mechanical memory

    DOE Patents [OSTI]

    Gilkey, Jeffrey C.; Duesterhaus, Michelle A.; Peter, Frank J.; Renn, Rosemarie A.; Baker, Michael S.

    2006-05-16

    A first-in-first-out (FIFO) microelectromechanical memory apparatus (also termed a mechanical memory) is disclosed. The mechanical memory utilizes a plurality of memory cells, with each memory cell having a beam which can be bowed in either of two directions of curvature to indicate two different logic states for that memory cell. The memory cells can be arranged around a wheel which operates as a clocking actuator to serially shift data from one memory cell to the next. The mechanical memory can be formed using conventional surface micromachining, and can be formed as either a nonvolatile memory or as a volatile memory.

  16. Agreement Mechanisms

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Agreement Mechanisms Agreement Mechanisms World-class experts and capabilities countering all aspects of explosive threats, and aiming predominantly at enhanced detection capabilities. CRADA: Cooperative Research and Development Agreement What is it? Work performed in collaboration with a sponsor. What does it do? Enables Los Alamos staff to participate with industry, academia, and nonprofit entities on collaborative R&D activities of mutual benefit. When is it used? An organization's

  17. Analytical solutions to matrix diffusion problems

    SciTech Connect (OSTI)

    Keklinen, Pekka

    2014-10-06

    We report an analytical method to solve in a few cases of practical interest the equations which have traditionally been proposed for the matrix diffusion problem. In matrix diffusion, elements dissolved in ground water can penetrate the porous rock surronuding the advective flow paths. In the context of radioactive waste repositories this phenomenon provides a mechanism by which the area of rock surface in contact with advecting elements is greatly enhanced, and can thus be an important delay mechanism. The cases solved are relevant for laboratory as well for in situ experiments. Solutions are given as integral representations well suited for easy numerical solution.

  18. Computational mechanics

    SciTech Connect (OSTI)

    Raboin, P J

    1998-01-01

    The Computational Mechanics thrust area is a vital and growing facet of the Mechanical Engineering Department at Lawrence Livermore National Laboratory (LLNL). This work supports the development of computational analysis tools in the areas of structural mechanics and heat transfer. Over 75 analysts depend on thrust area-supported software running on a variety of computing platforms to meet the demands of LLNL programs. Interactions with the Department of Defense (DOD) High Performance Computing and Modernization Program and the Defense Special Weapons Agency are of special importance as they support our ParaDyn project in its development of new parallel capabilities for DYNA3D. Working with DOD customers has been invaluable to driving this technology in directions mutually beneficial to the Department of Energy. Other projects associated with the Computational Mechanics thrust area include work with the Partnership for a New Generation Vehicle (PNGV) for ''Springback Predictability'' and with the Federal Aviation Administration (FAA) for the ''Development of Methodologies for Evaluating Containment and Mitigation of Uncontained Engine Debris.'' In this report for FY-97, there are five articles detailing three code development activities and two projects that synthesized new code capabilities with new analytic research in damage/failure and biomechanics. The article this year are: (1) Energy- and Momentum-Conserving Rigid-Body Contact for NIKE3D and DYNA3D; (2) Computational Modeling of Prosthetics: A New Approach to Implant Design; (3) Characterization of Laser-Induced Mechanical Failure Damage of Optical Components; (4) Parallel Algorithm Research for Solid Mechanics Applications Using Finite Element Analysis; and (5) An Accurate One-Step Elasto-Plasticity Algorithm for Shell Elements in DYNA3D.

  19. Evaluating indoor exposure modeling alternatives for LCA: A case study in the vehicle repair industry

    SciTech Connect (OSTI)

    Demou, Evangelia; Hellweg, Stefanie; Wilson, Michael P.; Hammond, S. Katharine; McKone, Thomas E.

    2009-05-01

    We evaluated three exposure models with data obtained from measurements among workers who use"aerosol" solvent products in the vehicle repair industry and with field experiments using these products to simulate the same exposure conditions. The three exposure models were the: 1) homogeneously-mixed-one-box model, 2) multi-zone model, and 3) eddy-diffusion model. Temporally differentiated real-time breathing zone volatile organic compound (VOC) concentration measurements, integrated far-field area samples, and simulated experiments were used in estimating parameters, such as emission rates, diffusivity, and near-field dimensions. We assessed differences in model input requirements and their efficacy for predictive modeling. The One-box model was not able to resemble the temporal profile of exposure concentrations, but it performed well concerning time-weighted exposure over extended time periods. However, this model required an adjustment for spatial concentration gradients. Multi-zone models and diffusion-models may solve this problem. However, we found that the reliable use of both these models requires extensive field data to appropriately define pivotal parameters such as diffusivity or near-field dimensions. We conclude that it is difficult to apply these models for predicting VOC exposures in the workplace. However, for comparative exposure scenarios in life-cycle assessment they may be useful.

  20. The Inhibiting Bisection Problem

    SciTech Connect (OSTI)

    Pinar, Ali; Fogel, Yonatan; Lesieutre, Bernard

    2006-12-18

    Given a graph where each vertex is assigned a generation orconsumption volume, we try to bisect the graph so that each part has asignificant generation/consumption mismatch, and the cutsize of thebisection is small. Our motivation comes from the vulnerability analysisof distribution systems such as the electric power system. We show thatthe constrained version of the problem, where we place either the cutsizeor the mismatch significance as a constraint and optimize the other, isNP-complete, and provide an integer programming formulation. We alsopropose an alternative relaxed formulation, which can trade-off betweenthe two objectives and show that the alternative formulation of theproblem can be solved in polynomial time by a maximum flow solver. Ourexperiments with benchmark electric power systems validate theeffectiveness of our methods.

  1. 21PF overpack problems

    SciTech Connect (OSTI)

    Kovac, F.M.

    1995-12-31

    The 21PF overpack has had severe metal corrosion and stress corrosion cracking (SCC) for many years. The US Department of Transportation (DOT) and the US Nuclear Regulatory Commission (NRC) have disallowed the use of overpacks containing high chloride foam. Corrosion and SCC of 21PF overpacks have been documented and papers have been presented at conferences about these issues. Regulatory agencies have restricted 21PF overpack use and have requested data to determine if phenolic foam overpacks not meeting original design specifications will be authorized for continued use. This paper details some of the problems experienced by users and relates actions of the DOT and NRC concerning these packages. Industry is working to correct deficiencies, but if they are not successful, the entire uranium enrichment industry will be severely impacted.

  2. Method of tissue repair using a composite material

    DOE Patents [OSTI]

    Hutchens, Stacy A.; Woodward, Jonathan; Evans, Barbara R.; O'Neill, Hugh M.

    2016-03-01

    A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.

  3. Method of tissue repair using a composite material

    DOE Patents [OSTI]

    Hutchens, Stacy A; Woodward, Jonathan; Evans, Barbara R; O'Neill, Hugh M

    2014-03-18

    A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.

  4. Fractofusion mechanism

    SciTech Connect (OSTI)

    Yasui, K. . Dept. of Physics)

    1992-11-01

    In this paper, the fractofusion mechanism of cold fusion is investigated theoretically. The conditions necessary for fractofusion during the absorption of deuterium atoms by palladium specimens (the condition of so-called cold fusion experiments) is clarified, including crack generation at grain boundaries, the high orientation angle of grains, rapid crack formation, the increase of electrical resistance around a crack, the large width of cracks, and the generation of many cracks. The origin and quantity of the electrical field inside cracks in the conductor are also clarified. By the fractofusion mechanism, the experimental facts that neutron emissions are observed in bursts, that sometimes they coincide with the deformation of a palladium specimen, and that in many experiments excess neutrons were not observed are qualitatively explained. The upper limit of the total fractofusion yields during the absorption of deuterium atoms by palladium specimens are estimated.

  5. Human HLTF mediates postreplication repair by its HIRAN domain-dependent replication fork remodelling

    SciTech Connect (OSTI)

    Achar, Yathish Jagadheesh; Balogh, David; Neculai, Dante; Juhasz, Szilvia; Morocz, Monika; Gali, Himabindu; Dhe-Paganon, Sirano; Venclovas, Česlovas; Haracska, Lajos

    2015-09-08

    Defects in the ability to respond properly to an unrepaired DNA lesion blocking replication promote genomic instability and cancer. Human HLTF, implicated in error-free replication of damaged DNA and tumour suppression, exhibits a HIRAN domain, a RING domain, and a SWI/SNF domain facilitating DNA-binding, PCNA-polyubiquitin-ligase, and dsDNA-translocase activities, respectively. Here, we investigate the mechanism of HLTF action with emphasis on its HIRAN domain. We found that in cells HLTF promotes the filling-in of gaps left opposite damaged DNA during replication, and this postreplication repair function depends on its HIRAN domain. Our biochemical assays show that HIRAN domain mutant HLTF proteins retain their ubiquitin ligase, ATPase and dsDNA translocase activities but are impaired in binding to a model replication fork. These data and our structural study indicate that the HIRAN domain recruits HLTF to a stalled replication fork, and it also provides the direction for the movement of the dsDNA translocase motor domain for fork reversal. We suggest functional similarities between the HIRAN, the OB, the HARP2, and other domains found in certain motor proteins, which may explain why only a subset of DNA translocases can carry out fork reversal.

  6. Deterioration of Pracana Dam due to ASR. Main features and repair works

    SciTech Connect (OSTI)

    Matos, D.S.; Camelo, S.; Silva, H.S.; Pinho, J.S.

    1995-12-31

    Some of the Portuguese concrete dams show evidences of ASR. In majority the phenomena is still benign. However, in a few cases some significant deterioration of ASR type have malfunctions arose. In such cases deteriorations of ASR type have been detected while in the others the ASSR type prevail, depending on the type of aggregate. The paper reports the most important case of ASR in Portuguese concrete dams. Pracana dam is a buttress structures built in 1948-51, being the aggregates predominantly of quartzitic and metapellitic nature. Subsequently to the intense fracturing due to a quick concrete cooling during the first filling of the reservoir, high levels of expansion rates had been detected by means of monitoring system. After 8 years emptied reservoir, rehabilitation works took place in 1991-92 aiming at the concrete mass regeneration and the installation of an upstream face membrane, the improvement of spillway capacity and of the foundation performances. The behaviour of the dam as well as the performed tests (petrographic, mechanic, ultrasonic and expansibility ones) and repair works are described in the paper.

  7. Human HLTF mediates postreplication repair by its HIRAN domain-dependent replication fork remodelling

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Achar, Yathish Jagadheesh; Balogh, David; Neculai, Dante; Juhasz, Szilvia; Morocz, Monika; Gali, Himabindu; Dhe-Paganon, Sirano; Venclovas, Česlovas; Haracska, Lajos

    2015-09-08

    Defects in the ability to respond properly to an unrepaired DNA lesion blocking replication promote genomic instability and cancer. Human HLTF, implicated in error-free replication of damaged DNA and tumour suppression, exhibits a HIRAN domain, a RING domain, and a SWI/SNF domain facilitating DNA-binding, PCNA-polyubiquitin-ligase, and dsDNA-translocase activities, respectively. Here, we investigate the mechanism of HLTF action with emphasis on its HIRAN domain. We found that in cells HLTF promotes the filling-in of gaps left opposite damaged DNA during replication, and this postreplication repair function depends on its HIRAN domain. Our biochemical assays show that HIRAN domain mutant HLTF proteinsmore » retain their ubiquitin ligase, ATPase and dsDNA translocase activities but are impaired in binding to a model replication fork. These data and our structural study indicate that the HIRAN domain recruits HLTF to a stalled replication fork, and it also provides the direction for the movement of the dsDNA translocase motor domain for fork reversal. We suggest functional similarities between the HIRAN, the OB, the HARP2, and other domains found in certain motor proteins, which may explain why only a subset of DNA translocases can carry out fork reversal.« less

  8. Smoothing of mixed complementarity problems

    SciTech Connect (OSTI)

    Gabriel, S.A.; More, J.J.

    1995-09-01

    The authors introduce a smoothing approach to the mixed complementarity problem, and study the limiting behavior of a path defined by approximate minimizers of a nonlinear least squares problem. The main result guarantees that, under a mild regularity condition, limit points of the iterates are solutions to the mixed complementarity problem. The analysis is applicable to a wide variety of algorithms suitable for large-scale mixed complementarity problems.

  9. Development and validation of bonded composite doubler repairs for commercial aircraft.

    SciTech Connect (OSTI)

    Roach, Dennis Patrick; Rackow, Kirk A.

    2007-07-01

    A typical aircraft can experience over 2,000 fatigue cycles (cabin pressurizations) and even greater flight hours in a single year. An unavoidable by-product of aircraft use is that crack, impact, and corrosion flaws develop throughout the aircraft's skin and substructure elements. Economic barriers to the purchase of new aircraft have placed even greater demands on efficient and safe repair methods. The use of bonded composite doublers offers the airframe manufacturers and aircraft maintenance facilities a cost effective method to safely extend the lives of their aircraft. Instead of riveting multiple steel or aluminum plates to facilitate an aircraft repair, it is now possible to bond a single Boron-Epoxy composite doubler to the damaged structure. The FAA's Airworthiness Assurance Center at Sandia National Labs (AANC), Boeing, and Federal Express completed a pilot program to validate and introduce composite doubler repair technology to the U.S. commercial aircraft industry. This project focused on repair of DC-10 fuselage structure and its primary goal was to demonstrate routine use of this repair technology using niche applications that streamline the design-to-installation process. As composite doubler repairs gradually appear in the commercial aircraft arena, successful flight operation data is being accumulated. These commercial aircraft repairs are not only demonstrating the engineering and economic advantages of composite doubler technology but they are also establishing the ability of commercial maintenance depots to safely adopt this repair technique. This report presents the array of engineering activities that were completed in order to make this technology available for widespread commercial aircraft use. Focused laboratory testing was conducted to compliment the field data and to address specific issues regarding damage tolerance and flaw growth in composite doubler repairs. Fatigue and strength tests were performed on a simulated wing repair using a

  10. DNA repair of a single UV photoproduct in a designed nucleosome

    SciTech Connect (OSTI)

    Kosmoskil, Joseph V.; Ackerman, Eric J. ); Smerdon, Michael J.

    2001-08-28

    Eukaryotic DNA repair enzymes must interact with the architectural hierarchy of chromatin. The challenge of finding damaged DNA complexed with histone proteins in nucleosomes is complicated by the need to maintain local chromatin structures involved in regulating other DNA processing events. The heterogeneity of lesions induced by DNA-damaging agents has led us to design homogeneously damaged substrates to directly compare repair of naked DNA with that of nucleosomes. Here we report that nucleotide excision repair in Xenopus nuclear extracts can effectively repair a single UV radiation photoproduct located 5 bases from the dyad center of a positioned nucleosome, although the nucleosome is repaired at about half the rate at which the naked DNA fragment is. Extract repair within the nucleosome is > 50-fold more rapid than either enzymatic photoreversal or endonuclease cleavage of the lesion in vitro. Furthermore, nucleosome formation occurs (after repair) only on damaged naked DNA ( 165-bp fragments) during a 1-h incubation in these extracts, even in the presence of a large excess of undamaged DNA. This is an example of selective nucleosome assembly by Xenopus nuclear extracts on a short linear DNA fragment containing a DNA lesion.

  11. Metal inhibition of human alkylpurine-DNA-N-glycosylase activityin base excision repair

    SciTech Connect (OSTI)

    Wang, Ping; Guliaev, Anton B.; Hang, Bo

    2006-02-28

    Cadmium (Cd{sup 2+}), nickel (Ni{sup 2+}) and cobalt (Co{sup 2+}) are human and/or animal carcinogens. Zinc (Zn{sup 2+}) is not categorized as a carcinogen, and rather an essential element to humans. Metals were recently shown to inhibit DNA repair proteins that use metals for their function and/or structure. Here we report that the divalent ions Cd{sup 2+}, Ni{sup 2+}, and Zn{sup 2+} can inhibit the activity of a recombinant human N-methylpurine-DNA glycosylase (MPG) toward a deoxyoligonucleotide with ethenoadenine (var epsilonA). MPG removes a variety of toxic/mutagenic alkylated bases and does not require metal for its catalytic activity or structural integrity. At concentrations starting from 50 to 1000 {micro}M, both Cd{sup 2+} and Zn{sup 2+} showed metal-dependent inhibition of the MPG catalytic activity. Ni{sup 2+} also inhibited MPG, but to a lesser extent. Such an effect can be reversed with EDTA addition. In contrast, Co{sup 2+} and Mg{sup 2+} did not inhibit the MPG activity in the same dose range. Experiments using HeLa cell-free extracts demonstrated similar patterns of inactivation of the var epsilonA excision activity by the same metals. Binding of MPG to the substrate was not significantly affected by Cd{sup 2+}, Zn{sup 2+}, and Ni{sup 2+} at concentrations that show strong inhibition of the catalytic function, suggesting that the reduced catalytic activity is not due to altered MPG binding affinity to the substrate. Molecular dynamics (MD) simulations with Zn{sup 2+} showed that the MPG active site has a potential binding site for Zn{sup 2+}, formed by several catalytically important and conserved residues. Metal binding to such a site is expected to interfere with the catalytic mechanism of this protein. These data suggest that inhibition of MPG activity may contribute to metal genotoxicity and depressed repair of alkylation damage by metals in vivo.

  12. ELEVATING MECHANISM

    DOE Patents [OSTI]

    Frederick, H.S.; Kinsella, M.A.

    1959-02-24

    An elevator is described, which is arranged for movement both in a horizontal and in a vertical direction so that the elevating mechanism may be employed for servicing equipment at separated points in a plant. In accordance with the present invention, the main elevator chassis is suspended from a monorail. The chassis, in turn supports a vertically moveable carriage, a sub- carriage vertically moveable on the carriage, and a turntable carried by the sub- carriage and moveable through an arc of 90 with the equipment attached thereto. In addition, the chassis supports all the means required to elevate or rotate the equipment.

  13. Emailed Comments of Elizabeth Chimento RE: Pepco Scheduled Line Repair Dec.

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    1-20, 2006 | Department of Energy Emailed Comments of Elizabeth Chimento RE: Pepco Scheduled Line Repair Dec. 1-20, 2006 Emailed Comments of Elizabeth Chimento RE: Pepco Scheduled Line Repair Dec. 1-20, 2006 Docket No. EO-05-01. Regarding the planned line outage, scheduled for Feb. 20 through Mar. 6, I am requesting that the residents near the plant be moved for the duration of the outage to protect their health. Emailed Comments of Elizabeth Chimento RE: Pepco Scheduled Line Repair Dec.

  14. About an Optimal Visiting Problem

    SciTech Connect (OSTI)

    Bagagiolo, Fabio Benetton, Michela

    2012-02-15

    In this paper we are concerned with the optimal control problem consisting in minimizing the time for reaching (visiting) a fixed number of target sets, in particular more than one target. Such a problem is of course reminiscent of the famous 'Traveling Salesman Problem' and brings all its computational difficulties. Our aim is to apply the dynamic programming technique in order to characterize the value function of the problem as the unique viscosity solution of a suitable Hamilton-Jacobi equation. We introduce some 'external' variables, one per target, which keep in memory whether the corresponding target is already visited or not, and we transform the visiting problem in a suitable Mayer problem. This fact allows us to overcome the lacking of the Dynamic Programming Principle for the originary problem. The external variables evolve with a hysteresis law and the Hamilton-Jacobi equation turns out to be discontinuous.

  15. In situ repair of a failed compression fitting

    DOE Patents [OSTI]

    Wolbert, R.R.; Jandrasits, W.G.

    1985-08-05

    A method and apparatus for the in situ repair of a failed compression fitting is provided. Initially, a portion of a guide tube is inserted coaxially in the bore of the compression fitting and locked therein. A close fit dethreading device is then coaxially mounted on the guide tube to cut the threads from the fitting. Thereafter, the dethreading device and guide tube are removed and a new fitting is inserted onto the dethreaded fitting with the body of the new fitting overlaying the dethreaded portion. Finally, the main body of the new fitting is welded to the main body of the old fitting whereby a new threaded portion of the replacement fitting is precisely coaxial with the old threaded portion. If needed, a bushing is located on the dethreaded portion which is sized to fit snugly between the dethreaded portion and the new fitting. Preferably, the dethreading device includes a cutting tool which is moved incrementally in a radial direction whereby the threads are cut from the threaded portion of the failed fitting in increments.

  16. In situ repair of a failed compression fitting

    DOE Patents [OSTI]

    Wolbert, Ronald R.; Jandrasits, Walter G.

    1986-01-01

    A method and apparatus for the in situ repair of a failed compression fitg is provided. Initially, a portion of a guide tube is inserted coaxially in the bore of the compression fitting and locked therein. A close fit dethreading device is then coaxially mounted on the guide tube to cut the threads from the fitting. Thereafter, the dethreading device and guide tube are removed and a new fitting is inserted onto the dethreaded fitting with the body of the new fitting overlaying the dethreaded portion. Finally, the main body of the new fitting is welded to the main body of the old fitting whereby a new threaded portion of the replacement fitting is precisely coaxial with the old threaded portion. If needed, a bushing is located on the dethreaded portion which is sized to fit snugly between the dethreaded portion and the new fitting. Preferably, the dethreading device includes a cutting tool which is moved incrementally in a radial direction whereby the threads are cut from the threaded portion of the failed fitting in increments.

  17. Review of Maintenance and Repair Times for Components in Technological Facilities

    SciTech Connect (OSTI)

    L. C. Cadwallader

    2012-11-01

    This report is a compilation of some unique component repair time data and it also presents citations of more extensive reports where lists of repair times can be found. This collection of information should support analysts who seek to quantify maintainability and availability of high technology and nuclear energy production systems. While there are newer sources of repair time information, most, if not all, of the newer sources are proprietary and cannot be shared. This report offers data that, while older, is openly accessible and can serve as reasonable estimates of repair times, at least for initial studies. Some times were found for maintenance times in radiation environments, and some guidance for multiplicative factors to use to account for work in contamination areas.

  18. Tiny Terminators: New Micro-Robots Assemble, Repair Themselves and Are Surprisingly Strong

    Broader source: Energy.gov [DOE]

    Tiny robots that can assemble and repair themselves? Watch a video of Argonne National Laboratory's micro-robots that easily perform tasks that can challenge other robots, including moving objects that are larger than themselves.

  19. Community-Minded Interns at Savannah River Site Help Area Residents in Need with Home Repairs

    Broader source: Energy.gov [DOE]

    AIKEN, S.C. – More than two dozen college interns who worked at the Savannah River Site (SRS) this summer joined other volunteers and headed into area neighborhoods to help people in need with home repairs.

  20. Results of fracture mechanics analyses of the ederer cranes in the device assembly

    SciTech Connect (OSTI)

    Dalder, E.

    1996-08-01

    Fracture mechanics analyses were conducted on three critical locations on the lower flange of the load-beam of the Ederer 5 ton and 4 ton cranes in the D.A.F. Facility. Based on these results, it appears that: 1. Propagation of a 5 mm long flaw, previously undetected by non-destructive examination (NDE), to a length sufficient to cause structural failure of either flange, should not occur in at least 100 times the postulated operating scenarios for each crane; 2. Should each crane undergo annual inspection, any surface flaw with a length greater that 20 mm should be removed and repaired by qualified and approved repair procedures.

  1. Method to repair localized amplitude defects in a EUV lithography mask blank

    DOE Patents [OSTI]

    Stearns, Daniel G.; Sweeney, Donald W.; Mirkarimi, Paul B.; Chapman, Henry N.

    2005-11-22

    A method and apparatus are provided for the repair of an amplitude defect in a multilayer coating. A significant number of layers underneath the amplitude defect are undamaged. The repair technique restores the local reflectivity of the coating by physically removing the defect and leaving a wide, shallow crater that exposes the underlying intact layers. The particle, pit or scratch is first removed the remaining damaged region is etched away without disturbing the intact underlying layers.

  2. RESTORING A DAMAGED 16-YEAR -OLD INSULATING POLYMER CONCRETE DIKE OVERLAY: REPAIR MATERIALS AND TECHNOLOGIES.

    SciTech Connect (OSTI)

    SUGAMA,T.

    2007-01-01

    The objective of this program was to design and formulate organic polymer-based material systems suitable for repairing and restoring the overlay panels of insulating lightweight polymer concrete (ILPC) from the concrete floor and slope wall of a dike at KeySpan liquefied natural gas (LNG) facility in Greenpoint, Brooklyn, NY, just over sixteen years ago. It also included undertaking a small-scale field demonstration to ensure that the commercial repairing technologies were applicable to the designed and formulated materials.

  3. Parallel Algebraic Multigrids for Structural mechanics

    SciTech Connect (OSTI)

    Brezina, M; Tong, C; Becker, R

    2004-05-11

    This paper presents the results of a comparison of three parallel algebraic multigrid (AMG) preconditioners for structural mechanics applications. In particular, they are interested in investigating both the scalability and robustness of the preconditioners. Numerical results are given for a range of structural mechanics problems with various degrees of difficulty.

  4. Mechanical Design

    SciTech Connect (OSTI)

    Shook, Richard; /Marquette U. /SLAC

    2010-08-25

    The particle beam of the SXR (soft x-ray) beam line in the LCLS (Linac Coherent Light Source) has a high intensity in order to penetrate through samples at the atomic level. However, the intensity is so high that many experiments fail because of severe damage. To correct this issue, attenuators are put into the beam line to reduce this intensity to a level suitable for experimentation. Attenuation is defined as 'the gradual loss in intensity of any flux through a medium' by [1]. It is found that Beryllium and Boron Carbide can survive the intensity of the beam. At very thin films, both of these materials work very well as filters for reducing the beam intensity. Using a total of 12 filters, the first 9 being made of Beryllium and the rest made of Boron Carbide, the beam's energy range of photons can be attenuated between 800 eV and 9000 eV. The design of the filters allows attenuation for different beam intensities so that experiments can obtain different intensities from the beam if desired. The step of attenuation varies, but is relative to the thickness of the filter as a power function of 2. A relationship for this is f(n) = x{sub 0}2{sup n} where n is the step of attenuation desired and x{sub 0} is the initial thickness of the material. To allow for this desired variation, a mechanism must be designed within the test chamber. This is visualized using a 3D computer aided design modeling tool known as Solid Edge.

  5. Relocation and repair of the National Geotechnical Centrifuge. Final report

    SciTech Connect (OSTI)

    Cheney, J.A.

    1994-10-01

    In January of 1984, the large geotechnical centrifuge located at NASA Ames Research Center, was in the first stages of operational checkout when the main thrust bearing of the large D.C. drive motor failed. After many months of investigation and proposals for repair of the facility, it became evident that it would be far more advantageous to the engineering community to remove those components of the centrifuge that were undamaged to the Davis campus and replace the drive system completely. The large centrifuge had cost over 2 million dollars to build, and it would have been irresponsible to simply scrap it. Recognizing this fact, funds were solicited and received from various sources, and Beam Engineering Inc. was contracted to design and construct the centrifuge at its new location. The University of California contributed a quarter of a million dollars and Tyndall Air Force Base, through Los Alamos National Laboratory, contributed $140,000. There were funds also contributed by LANL, LLNL, US Navy and NSF. The first stage in the phased development of the newly located centrifuge is nearing completion, which prompts the writing of this report. By the time that this report reaches the reader the first runs of the centrifuge will have been completed. The present report describes the present capability of the centrifuge and the plans for upgrading as time goes on. Several pilot studies were carried out. The experiments involved (1) the effects of nearby explosions on buried thin walled containers and (2) the advection and dispersion of toxic waste water through soils.

  6. Further Evolution of Composite Doubler Aircraft Repairs Through a Focus on Niche Applications

    SciTech Connect (OSTI)

    ROACH,DENNIS P.

    2000-07-15

    The number of commercial airframes exceeding twenty years of service continues to grow. A typical aircraft can experience over 2,000 fatigue cycles (cabin pressurizations) and even greater flight hours in a single year. An unavoidable by-product of aircraft use is that crack and corrosion flaws develop throughout the aircraft's skin and substructure elements. Economic barriers to the purchase of new aircraft have created an aging aircraft fleet and placed even greater demands on efficient and safe repair methods. The use of bonded composite doublers offers the airframe manufacturers and aircraft maintenance facilities a cost effective method to safety extend the lives of their aircraft. Instead of riveting multiple steel or aluminum plates to facilitate an aircraft repair, it is now possible to bond a single Boron-Epoxy composite doubler to the damaged structure. The FAA's Airworthiness Assurance Center at Sandia National Labs (AANC) is conducting a program with Boeing and Federal Express to validate and introduce composite doubler repair technology to the US commercial aircraft industry. This project focuses on repair of DC-10 structure and builds on the foundation of the successful L-1011 door corner repair that was completed by the AANC, Lockheed-Martin, and Delta Air Lines. The L-1011 composite doubler repair was installed in 1997 and has not developed any flaws in over three years of service, As a follow-on effort, this DC-1O repair program investigated design, analysis, performance (durability, flaw containment, reliability), installation, and nondestructive inspection issues. Current activities are demonstrating regular use of composite doubler repairs on commercial aircraft. The primary goal of this program is to move the technology into niche applications and to streamline the design-to-installation process. Using the data accumulated to date, the team has designed, analyzed, and developed inspection techniques for an array of composite doubler repairs

  7. DNA repair decline during mouse spermiogenesis results in the accumulation of heritable DNA damage

    SciTech Connect (OSTI)

    Marchetti, Francesco; Marchetti, Francesco; Wryobek, Andrew J

    2008-02-21

    The post-meiotic phase of mouse spermatogenesis (spermiogenesis) is very sensitive to the genomic effects of environmental mutagens because as male germ cells form mature sperm they progressively lose the ability to repair DNA damage. We hypothesized that repeated exposures to mutagens during this repair-deficient phase result in the accumulation of heritable genomic damage in mouse sperm that leads to chromosomal aberrations in zygotes after fertilization. We used a combination of single or fractionated exposures to diepoxybutane (DEB), a component of tobacco smoke, to investigate how differential DNA repair efficiencies during the three weeks of spermiogenesis affected the accumulation of DEB-induced heritable damage in early spermatids (21-15 days before fertilization, dbf), late spermatids (14-8 dbf) and sperm (7- 1 dbf). Analysis of chromosomalaberrations in zygotic metaphases using PAINT/DAPI showed that late spermatids and sperm are unable to repair DEB-induced DNA damage as demonstrated by significant increases (P<0.001) in the frequencies of zygotes with chromosomal aberrations. Comparisons between single and fractionated exposures suggested that the DNA repair-deficient window during late spermiogenesis may be less than two weeks in the mouse and that during this repair-deficient window there is accumulation of DNA damage in sperm. Finally, the dose-response study in sperm indicated a linear response for both single and repeated exposures. These findings show that the differential DNA repair capacity of post-meioitic male germ cells has a major impact on the risk of paternally transmitted heritable damage and suggest that chronic exposures that may occur in the weeks prior to fertilization because of occupational or lifestyle factors (i.e, smoking) can lead to an accumulation of genetic damage in sperm and result in heritable chromosomal aberrations of paternal origin.

  8. DNA Repair Decline During Mouse Spermiogenesis Results in the Accumulation of Heritable DNA Damage

    SciTech Connect (OSTI)

    Marchetti, Francesco; Marchetti, Francesco; Wyrobek, Andrew J.

    2007-12-01

    The post-meiotic phase of mouse spermatogenesis (spermiogenesis) is very sensitive to the genomic effects of environmental mutagens because as male germ cells form mature sperm they progressively lose the ability to repair DNA damage. We hypothesized that repeated exposures to mutagens during this repair-deficient phase result in the accumulation of heritable genomic damage in mouse sperm that leads to chromosomal aberrations in zygotes after fertilization. We used a combination of single or fractionated exposures to diepoxybutane (DEB), a component of tobacco smoke, to investigate how differential DNA repair efficiencies during the three weeks of spermiogenesis affected the accumulation of DEB-induced heritable damage in early spermatids (21-15 days before fertilization, dbf), late spermatids (14-8 dbf) and sperm (7-1 dbf). Analysis of chromosomal aberrations in zygotic metaphases using PAINT/DAPI showed that late spermatids and sperm are unable to repair DEB-induced DNA damage as demonstrated by significant increases (P<0.001) in the frequencies of zygotes with chromosomal aberrations. Comparisons between single and fractionated exposures suggested that the DNA repair-deficient window during late spermiogenesis may be less than two weeks in the mouse and that during this repair-deficient window there is accumulation of DNA damage in sperm. Finally, the dose-response study in sperm indicated a linear response for both single and repeated exposures. These findings show that the differential DNA repair capacity of post-meioitic male germ cells has a major impact on the risk of paternally transmitted heritable damage and suggest that chronic exposures that may occur in the weeks prior to fertilization because of occupational or lifestyle factors (i.e, smoking) can lead to an accumulation of genetic damage in sperm and result in heritable chromosomal aberrations of paternal origin.

  9. Heavy Mobile Equipment Mechanic (One Mechanic Shop)

    Broader source: Energy.gov [DOE]

    Join the Bonneville Power Administration (BPA) for a challenging and rewarding career, while working, living, and playing in the Pacific Northwest. The Heavy Mobile Equipment Mechanic (One Mechanic...

  10. Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    energy solutions, Sandia and Princeton Power Systems have teamed up to develop the Demand Response Inverter (DRI). Innovative Edge The DRI is a power flow control system...

  11. Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    They can reduce the size and weight of existing next-generation smart grid power electronics systems, allowing greater application in such areas as weapons systems and pulsed...

  12. Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    In addition, Sandia's method is compatible with conventional spray processing and, ... process include high-definition flat panel displays, sensor coatings for both ...

  13. Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    But what if the batteries had the ability to recharge themselves? What if they were covered by a thin photovoltaic (PV) film that could harvest energy from the sun? Just as on ...

  14. Surrogate Guderley Test Problem Definition

    SciTech Connect (OSTI)

    Ramsey, Scott D.; Shashkov, Mikhail J.

    2012-07-06

    The surrogate Guderley problem (SGP) is a 'spherical shock tube' (or 'spherical driven implosion') designed to ease the notoriously subtle initialization of the true Guderley problem, while still maintaining a high degree of fidelity. In this problem (similar to the Guderley problem), an infinitely strong shock wave forms and converges in one-dimensional (1D) cylindrical or spherical symmetry through a polytropic gas with arbitrary adiabatic index {gamma}, uniform density {rho}{sub 0}, zero velocity, and negligible pre-shock pressure and specific internal energy (SIE). This shock proceeds to focus on the point or axis of symmetry at r = 0 (resulting in ostensibly infinite pressure, velocity, etc.) and reflect back out into the incoming perturbed gas.

  15. Working report and instruction for repairing of three peaces of wings from a 30 kW Riisagermill

    SciTech Connect (OSTI)

    Ethelfeld, J.; Jensen, F.; Kjoller, J.; Lystrup, A.

    1980-01-01

    This report is made to give the owners of Riisager windmills an instruction to make service and repair of the fiber glass wings.

  16. SEACAS Theory Manuals: Part II. Nonlinear Continuum Mechanics

    SciTech Connect (OSTI)

    Attaway, S.W.; Laursen, T.A.; Zadoks, R.I.

    1998-09-01

    This report summarizes the key continuum mechanics concepts required for the systematic prescription and numerical solution of finite deformation solid mechanics problems. Topics surveyed include measures of deformation appropriate for media undergoing large deformations, stress measures appropriate for such problems, balance laws and their role in nonlinear continuum mechanics, the role of frame indifference in description of large deformation response, and the extension of these theories to encompass two dimensional idealizations, structural idealizations, and rigid body behavior. There are three companion reports that describe the problem formulation, constitutive modeling, and finite element technology for nonlinear continuum mechanics systems.

  17. Alternatives Analysis Amchitka Island Mud Pit Cap Repair, Amchitka, Alaska January 2016

    SciTech Connect (OSTI)

    Darr, Paul S.

    2016-01-01

    The U.S. Department of Energy (DOE) Office of Legacy Management (LM) manages the Nevada Offsites program, which includes a series of reclaimed drilling mud impoundments on Amchitka Island, Alaska (Figure 1). Navarro Research and Engineering, Inc. is the Legacy Management Support contractor (the Contractor) for LM. The Contractor has procured Tetra Tech, Inc. to provide engineering support to the Amchitka mud pit reclamation project. The mud pit caps were damaged during a 7.9-magnitude earthquake that occurred in 2014. The goals of the current project are to investigate conditions at the mud pit impoundments, identify feasible alternatives for repair of the cover systems and the contents, and estimate relative costs of repair alternatives. This report presents descriptions of the sites and past investigations, existing conditions, summaries of various repair/mitigation alternatives, and direct, unburdened, order-of-magnitude (-15% to +50%) associated costs.

  18. A survey of repair practices for nuclear power plant containment metallic pressure boundaries

    SciTech Connect (OSTI)

    Oland, C.B.; Naus, D.J.

    1998-05-01

    The Nuclear Regulatory Commission has initiated a program at the Oak Ridge National Laboratory to provide assistance in their assessment of the effects of potential degradation on the structural integrity and leaktightness of metal containment vessels and steel liners of concrete containments in nuclear power plants. One of the program objectives is to identify repair practices for restoring metallic containment pressure boundary components that have been damaged or degraded in service. This report presents issues associated with inservice condition assessments and continued service evaluations and identifies the rules and requirements for the repair and replacement of nonconforming containment pressure boundary components by welding or metal removal. Discussion topics include base and welding materials, welding procedure and performance qualifications, inspection techniques, testing methods, acceptance criteria, and documentation requirements necessary for making acceptable repairs and replacements so that the plant can be returned to a safe operating condition.

  19. Automatic coke oven heating control system at Burns Harbor for normal and repair operation

    SciTech Connect (OSTI)

    Battle, E.T.; Chen, K.L.

    1997-12-31

    An automatic heating control system for coke oven batteries was developed in 1985 for the Burns Harbor No. 1 battery and reported in the 1989 Ironmaking Conference Proceedings. The original system was designed to maintain a target coke temperature at a given production level under normal operating conditions. Since 1989, enhancements have been made to this control system so that it can also control the battery heating when the battery is under repair. The new control system has improved heating control capability because it adjusts the heat input to the battery in response to anticipated changes in the production schedule. During a recent repair of this 82 oven battery, the pushing schedule changed from 102 ovens/day to 88 ovens/day, then back to 102 ovens/day, then to 107 ovens/day. During this repair, the control system was able to maintain the coke temperature average standard deviation at 44 F, with a maximum 75 F.

  20. Evaluation of bisphenol E cyanate ester for the resin-injection repair of advanced composites

    SciTech Connect (OSTI)

    Wilber Yaote Lio

    2009-12-19

    This thesis is a compilation of a general introduction and literature review that ties together the subsequent chapters which consist of two journal articles that have yet to be submitted for publication. The overall topic relates to the evaluation and application of a new class of cyanate ester resin with unique properties that lend it applicable to use as a resin for injection repair of high glass transition temperature polymer matrix composites. The first article (Chapter 2) details the evaluation and optimization of adhesive properties of this cyanate ester and alumina nanocomposites under different conditions. The second article (Chapter 3) describes the development and evaluation of an injection repair system for repairing delaminations in polymer matrix composites.

  1. Operating experience review of service water system problems

    SciTech Connect (OSTI)

    Lam, P.

    1989-01-01

    In a recent paper, selected results of a comprehensive review and evaluation of service water system problems conducted by the Office for Analysis and Evaluation of Operational Data (AEOD) of the US Nuclear Regulatory Commission (NRC) were presented. The results of this review and evaluation indicated that service water system problems have significant safety implications. These system problems are attributable to a great variety of causes and have adverse impacts on a large number of safety-related systems and components. To provide additional feedback of operating experience, this paper presents an overview of the dominant mechanisms leading to service water system degradations and failures. The failures and degradations of service water systems observed in the 276 operating events are grouped into six general categories. The six general categories are (1) fouling due to various mechanisms, (2) single-failure and other design deficiencies, (3) flooding, (4) equipment failures, (5) personnel and procedural errors, and (6) seismic deficiencies.

  2. Challenge problems for artificial intelligence

    SciTech Connect (OSTI)

    Selman, B.; Brooks, R.A.; Dean, T.

    1996-12-31

    AI textbooks and papers of ten discuss the big questions, such as {open_quotes}how to reason with uncertainty{close_quotes}, {open_quotes}how to reason efficiently{close_quotes}, or {open_quotes}how to improve performance through learning.{close_quotes} It is more difficult, however, to find descriptions of concrete problems or challenges that are still ambitious and interesting, yet not so open-ended. The goal of this panel is to formulate a set of such challenge problems for the field. Each panelist was asked to formulate one or more challenges. The emphasis is on problems for which there is a good chance that they will be resolved within the next five to ten years.

  3. Remote reactor repair: GTA (gas tungsten Arc) weld cracking caused by entrapped helium

    SciTech Connect (OSTI)

    Kanne, W.R. Jr.

    1988-01-01

    A repair patch was welded to the wall of a nuclear reactor tank using remotely controlled thirty-foot long robot arms. Further repair was halted when gas tungsten arc (GTA) welds joining type 304L stainless steel patches to the 304 stainless steel wall developed toe cracks in the heat-affected zone (HAZ). The role of helium in cracking was investigated using material with entrapped helium from tritium decay. As a result of this investigation, and of an extensive array of diagnostic tests performed on reactor tank wall material, helium embrittlement was shown to be the cause of the toe cracks.

  4. Bosh repairs No. 3 blast furnace, Edgar Thomson Plant Mon Valley Works

    SciTech Connect (OSTI)

    Stoupis, M.G.

    1993-01-01

    The paper describes in detail the steps taken from quenching to dry out of the furnace to repair the bosh area of the No.3 blast furnace. Inspection of the area revealed that there was no brick anywhere in the bosh. Brick in the tuyere breast area had been peeled back to reveal the steel plate, and descaling revealed 14 pipes fully exposed. None were leaking, but one seemed badly deteriorated. Conventional repairs could not take place before the scheduled blow-in. Installation of coolers were instead tried.

  5. Current problems in plasma spray processing

    SciTech Connect (OSTI)

    Berndt, C.C.; Brindley, W.; Goland, A.N.; Herman, H.; Houck, D.L.; Jones, K.; Miller, R.A.; Neiser, R.; Riggs, W.; Sampath, S.; Smith, M.; Spanne, P.

    1991-12-31

    This detailed report summarizes 8 contributions from a thermal spray conference that was held in late 1991 at Brookhaven National Laboratory (Upton, Long Island, NY, USA). The subject of ``Plasma Spray Processing`` is presented under subject headings of Plasma-particle interactions, Deposit formation dynamics, Thermal properties of thermal barrier coatings, Mechanical properties of coatings, Feed stock materials, Porosity: An integrated approach, Manufacture of intermetallic coatings, and Synchrotron x-ray microtomographic methods for thermal spray materials. Each section is intended to present a concise statement of a specific practical and/or scientific problem, then describe current work that is being performed to investigate this area, and finally to suggest areas of research that may be fertile for future activity.

  6. Current problems in plasma spray processing

    SciTech Connect (OSTI)

    Berndt, C.C.; Brindley, W.; Goland, A.N.; Herman, H.; Houck, D.L.; Jones, K.; Miller, R.A.; Neiser, R.; Riggs, W.; Sampath, S.; Smith, M.; Spanne, P. . Thermal Spray Lab.)

    1991-01-01

    This detailed report summarizes 8 contributions from a thermal spray conference that was held in late 1991 at Brookhaven National Laboratory (Upton, Long Island, NY, USA). The subject of Plasma Spray Processing'' is presented under subject headings of Plasma-particle interactions, Deposit formation dynamics, Thermal properties of thermal barrier coatings, Mechanical properties of coatings, Feed stock materials, Porosity: An integrated approach, Manufacture of intermetallic coatings, and Synchrotron x-ray microtomographic methods for thermal spray materials. Each section is intended to present a concise statement of a specific practical and/or scientific problem, then describe current work that is being performed to investigate this area, and finally to suggest areas of research that may be fertile for future activity.

  7. Substation automation problems and possibilities

    SciTech Connect (OSTI)

    Smith, H.L.

    1996-10-01

    The evolutionary growth in the use and application of microprocessors in substations has brought the industry to the point of considering integrated substation protection, control, and monitoring systems. An integrated system holds the promise of greatly reducing the design, documentation, and implementation cost for the substation control, protection, and monitoring systems. This article examines the technical development path and the present implementation problems.

  8. Sour landfill gas problem solved

    SciTech Connect (OSTI)

    Nagl, G.; Cantrall, R.

    1996-05-01

    In Broward County, Fla., near Pompano Beach, Waste Management of North America (WMNA, a subsidiary of WMX Technologies, Oak Brook, IL) operates the Central Sanitary Landfill and Recycling Center, which includes the country`s largest landfill gas-to-energy plant. The landfill consists of three collection sites: one site is closed, one is currently receiving garbage, and one will open in the future. Approximately 9 million standard cubic feet (scf) per day of landfill gas is collected from approximately 300 wells spread over the 250-acre landfill. With a dramatic increase of sulfur-containing waste coming to a South Florida landfill following Hurricane Andrew, odors related to hydrogen sulfide became a serious problem. However, in a matter of weeks, an innovative desulfurization unit helped calm the landfill operator`s fears. These very high H{sub 2}S concentrations caused severe odor problems in the surrounding residential area, corrosion problems in the compressors, and sulfur dioxide (SO{sub 2}) emission problems in the exhaust gas from the turbine generators.

  9. Hot repair of ceramic burner on hot blast stoves at USS/Kobe`s {number_sign}3 blast furnace

    SciTech Connect (OSTI)

    Bernarding, T.F.; Chemorov, M.; Shimono, S.; Phillips, G.R.

    1997-12-31

    During the 1992 reline of the No. 3 blast furnace, three new stoves were constructed. The design of the stoves, equipped with internal ceramic burners, was for providing a hot blast temperature of 2,000 F at a wind rate of 140,000 SCFM. After 3 years the performance had deteriorated so the burners were cleaned. When a second cleaning did not improve the performance of No. 3 blast furnace, it was decided to repair the refractory while still hot. The paper describes the hot repair procedures, taking a stove off for repairs, maintenance heat up during repairs, two stove operation, stove commissioning, repair of a ceramic burner, and wet gas prevention.

  10. CrowdPhase: crowdsourcing the phase problem

    SciTech Connect (OSTI)

    Jorda, Julien; Sawaya, Michael R.; Yeates, Todd O.

    2014-06-01

    The idea of attacking the phase problem by crowdsourcing is introduced. Using an interactive, multi-player, web-based system, participants work simultaneously to select phase sets that correspond to better electron-density maps in order to solve low-resolution phasing problems. The human mind innately excels at some complex tasks that are difficult to solve using computers alone. For complex problems amenable to parallelization, strategies can be developed to exploit human intelligence in a collective form: such approaches are sometimes referred to as ‘crowdsourcing’. Here, a first attempt at a crowdsourced approach for low-resolution ab initio phasing in macromolecular crystallography is proposed. A collaborative online game named CrowdPhase was designed, which relies on a human-powered genetic algorithm, where players control the selection mechanism during the evolutionary process. The algorithm starts from a population of ‘individuals’, each with a random genetic makeup, in this case a map prepared from a random set of phases, and tries to cause the population to evolve towards individuals with better phases based on Darwinian survival of the fittest. Players apply their pattern-recognition capabilities to evaluate the electron-density maps generated from these sets of phases and to select the fittest individuals. A user-friendly interface, a training stage and a competitive scoring system foster a network of well trained players who can guide the genetic algorithm towards better solutions from generation to generation via gameplay. CrowdPhase was applied to two synthetic low-resolution phasing puzzles and it was shown that players could successfully obtain phase sets in the 30° phase error range and corresponding molecular envelopes showing agreement with the low-resolution models. The successful preliminary studies suggest that with further development the crowdsourcing approach could fill a gap in current crystallographic methods by making it

  11. Multilayer sulfur-resistant composite metal membranes and methods of making and repairing the same

    DOE Patents [OSTI]

    Way, J. Douglas; Hatlevik, Oyvind

    2014-07-15

    The invention relates to thin, hydrogen-permeable, sulfur-resistant membranes formed from multi-layers of palladium or palladium-alloy coatings on porous, ceramic or metal supports, methods of making these membranes, methods of repairing layers of these membranes and devices that incorporate these membranes.

  12. Retrofitting and the mu Problem

    SciTech Connect (OSTI)

    Green, Daniel; Weigand, Timo; /SLAC /Stanford U., Phys. Dept.

    2010-08-26

    One of the challenges of supersymmetry (SUSY) breaking and mediation is generating a {mu} term consistent with the requirements of electro-weak symmetry breaking. The most common approach to the problem is to generate the {mu} term through a SUSY breaking F-term. Often these models produce unacceptably large B{mu} terms as a result. We will present an alternate approach, where the {mu} term is generated directly by non-perturtative effects. The same non-perturbative effect will also retrofit the model of SUSY breaking in such a way that {mu} is at the same scale as masses of the Standard Model superpartners. Because the {mu} term is not directly generated by SUSY breaking effects, there is no associated B{mu} problem. These results are demonstrated in a toy model where a stringy instanton generates {mu}.

  13. SEACAS Theory Manuals: Part 1. Problem Formulation in Nonlinear Solid Mechancis

    SciTech Connect (OSTI)

    Attaway, S.W.; Laursen, T.A.; Zadoks, R.I.

    1998-08-01

    This report gives an introduction to the basic concepts and principles involved in the formulation of nonlinear problems in solid mechanics. By way of motivation, the discussion begins with a survey of some of the important sources of nonlinearity in solid mechanics applications, using wherever possible simple one dimensional idealizations to demonstrate the physical concepts. This discussion is then generalized by presenting generic statements of initial/boundary value problems in solid mechanics, using linear elasticity as a template and encompassing such ideas as strong and weak forms of boundary value problems, boundary and initial conditions, and dynamic and quasistatic idealizations. The notational framework used for the linearized problem is then extended to account for finite deformation of possibly inelastic solids, providing the context for the descriptions of nonlinear continuum mechanics, constitutive modeling, and finite element technology given in three companion reports.

  14. Solving the Dark Matter Problem

    ScienceCinema (OSTI)

    Baltz, Ted

    2009-09-01

    Cosmological observations have firmly established that the majority of matter in the universe is of an unknown type, called 'dark matter'. A compelling hypothesis is that the dark matter consists of weakly interacting massive particles (WIMPs) in the mass range around 100 GeV. If the WIMP hypothesis is correct, such particles could be created and studied at accelerators. Furthermore they could be directly detected as the primary component of our galaxy. Solving the dark matter problem requires that the connection be made between the two. We describe some theoretical and experimental avenues that might lead to this connection.

  15. Common Air Conditioner Problems | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Common Air Conditioner Problems Common Air Conditioner Problems A refrigerant leak is one common air conditioning problem. | Photo courtesy of ©iStockphoto/BanksPhotos. A refrigerant leak is one common air conditioning problem. | Photo courtesy of ©iStockphoto/BanksPhotos. One of the most common air conditioning problems is improper operation. If your air conditioner is on, be sure to close your home's windows and outside doors. For room air conditioners, isolate the room or a group of

  16. Cosmological moduli problem in large volume scenario and thermal inflation

    SciTech Connect (OSTI)

    Choi, Kiwoon; Park, Wan-Il; Shin, Chang Sub E-mail: wipark@kias.re.kr

    2013-03-01

    We show that in a large volume scenario of type IIB string or F-theory compactifications, single thermal inflation provides only a partial solution to the cosmological problem of the light volume modulus. We then clarify the conditions for double thermal inflation, being a simple extension of the usual single thermal inflation scenario, to solve the cosmological moduli problem in the case of relatively light moduli masses. Using a specific example, we demonstrate that double thermal inflation can be realized in large volume scenario in a natural manner, and the problem of the light volume modulus can be solved for the whole relevant mass range. We also find that right amount of baryon asymmetry and dark matter can be obtained via a late-time Affleck-Dine mechanism and the decays of the visible sector NLSP to flatino LSP.

  17. Tensile strengths of problem shales and clays. Master's thesis

    SciTech Connect (OSTI)

    Rechner, F.J.

    1990-01-01

    The greatest single expense faced by oil companies involved in the exploration for crude oil is that of drilling wells. The most abundant rock drilled is shale. Some of these shales cause wellbore stability problems during the drilling process. These can range from slow rate of penetration and high torque up to stuck pipe and hole abandonment. The mechanical integrity of the shale must be known when the shalers are subjected to drilling fluids to develop an effective drilling plan.

  18. Repair of localized defects in multilayer-coated reticle blanks for extreme ultraviolet lithography

    DOE Patents [OSTI]

    Stearns, Daniel G.; Sweeney, Donald W.; Mirkarimi, Paul B.

    2004-11-23

    A method is provided for repairing defects in a multilayer coating layered onto a reticle blank used in an extreme ultraviolet lithography (EUVL) system. Using high lateral spatial resolution, energy is deposited in the multilayer coating in the vicinity of the defect. This can be accomplished using a focused electron beam, focused ion beam or a focused electromagnetic radiation. The absorbed energy will cause a structural modification of the film, producing a localized change in the film thickness. The change in film thickness can be controlled with sub-nanometer accuracy by adjusting the energy dose. The lateral spatial resolution of the thickness modification is controlled by the localization of the energy deposition. The film thickness is adjusted locally to correct the perturbation of the reflected field. For example, when the structural modification is a localized film contraction, the repair of a defect consists of flattening a mound or spreading out the sides of a depression.

  19. Subterranean barriers, methods, and apparatuses for forming, inspecting, selectively heating, and repairing same

    DOE Patents [OSTI]

    Nickelson, Reva A.; Sloan, Paul A.; Richardson, John G.; Walsh, Stephanie; Kostelnik, Kevin M.

    2009-04-07

    A subterranean barrier and method for forming same are disclosed, the barrier including a plurality of casing strings wherein at least one casing string of the plurality of casing strings may be affixed to at least another adjacent casing string of the plurality of casing strings through at least one weld, at least one adhesive joint, or both. A method and system for nondestructively inspecting a subterranean barrier is disclosed. For instance, a radiographic signal may be emitted from within a casing string toward an adjacent casing string and the radiographic signal may be detected from within the adjacent casing string. A method of repairing a barrier including removing at least a portion of a casing string and welding a repair element within the casing string is disclosed. A method of selectively heating at least one casing string forming at least a portion of a subterranean barrier is disclosed.

  20. Endovascular Repair of a Ruptured Mycotic Aneurysm of the Common Iliac Artery

    SciTech Connect (OSTI)

    Mofidi, R. Bhat, R.; Nagy, J.; Griffiths, G. D.; Chakraverty, S.

    2007-09-15

    This report describes the case of a ruptured mycotic aneurysm of the left common iliac artery, successfully treated with endovascular stent-grafting. A 64-year-old woman underwent diagnostic coronary angiography complicated by an infected hematoma of the left groin. Seven days later, she developed methicillin-resistant Staphylococcus aureus septicemia and CT scan evidence of perivascular inflammation around the left common iliac artery. This was followed by rupture of a mycotic aneurysm of the left common iliac artery. The lesion was successfully treated with a stent-graft and prolonged antibiotic therapy, and the patient remains free of infection 10 months later. Accumulating evidence suggests that endovascular repair can be used safely for the repair of ruptured infected aneurysms.

  1. Weld Repair of a Stamped Pressure Vessel in a Radiologically Controlled Zone

    SciTech Connect (OSTI)

    Cannell, Gary L.; Huth, Ralph J.; Hallum, Randall T.

    2013-08-26

    In September 2012 an ASME B&PVC Section VIII stamped pressure vessel located at the DOE Hanford Site Effluent Treatment Facility (ETF) developed a through-wall leak. The vessel, a steam/brine heat exchanger, operated in a radiologically controlled zone (by the CH2MHill PRC or CHPRC), had been in service for approximately 17 years. The heat exchanger is part of a single train evaporator process and its failure caused the entire system to be shut down, significantly impacting facility operations. This paper describes the activities associated with failure characterization, technical decision making/planning for repair by welding, logistical challenges associated with performing work in a radiologically controlled zone, performing the repair, and administrative considerations related to ASME code requirements.

  2. Quantum simulations of physics problems

    SciTech Connect (OSTI)

    Somma, R. D.; Ortiz, G.; Knill, E. H.; Gubernatis, J. E.

    2003-01-01

    If a large Quantum Computer (QC) existed today, what type of physical problems could we efficiently simulate on it that we could not efficiently simulate on a classical Turing machine? In this paper we argue that a QC could solve some relevant physical 'questions' more efficiently. The existence of one-to-one mappings between different algebras of observables or between different Hilbert spaces allow us to represent and imitate any physical system by any other one (e.g., a bosonic system by a spin-1/2 system). We explain how these mappings can be performed, and we show quantum networks useful for the efficient evaluation of some physical properties, such as correlation functions and energy spectra.

  3. To: Mansueti, Lawrence Subject: RE: Pepco Scheduled Line Repair Dec. 1-20, 2006

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    From: ecchimento@comcast.net [mailto:ecchimento@comcast.net] Sent: Monday, January 29, 2007 6:28 PM To: Mansueti, Lawrence Subject: RE: Pepco Scheduled Line Repair Dec. 1-20, 2006 Larry, Regarding the planned line outage, scheduled for Feb. 20 through Mar. 6, I am requesting that the residents near the plant be moved for the duration of the outage to protect their health. Would you include this comment also in the ongoing recorded discussion? Thank you. Elizabeth -----Original Message-----

  4. Analysis and testing of the DIII-D ohmic heating coil lead repair clamp

    SciTech Connect (OSTI)

    Reis, E.E.; Anderson, P.M.; Chin, E.; Robinson, J.I.

    1997-11-01

    DIII-D has been operating for the last year with limited volt-second capabilities due to structural failure of a conductor lead to one of the ohmic heating (OH) solenoids. The conductor failure was due to poor epoxy impregnation of the overwrap of the lead pack, resulting in copper fatigue and a water leak. A number of structural analyses were performed to assist in determining the failure scenario and to evaluate various repair options. A fatigue stress analysis of the leads with a failed epoxy overwrap indicated crack initiation after 1,000 cycles at the maximum operating conditions. The failure occurred in a very inaccessible area which restricted design repair options to concepts which could be implemented remotely. Several design options were considered for repairing the lead so that it can sustain the loads for 7.5 Vs conditions at full toroidal field. A clamp, along with preloaded banding straps and shim bags, provides a system that guarantees that the stress at the crack location is always compressive and prevents further crack growth in the conductor. Due to the limited space available for the repair, it was necessary to design the clamp system to operate at the material yield stress. The primary components of the clamp system were verified by load tests prior to installation. The main body of the clamp contains a load cell and potentiometer for monitoring the load-deflection characteristics of the clamp and conductors during plasma operation. Strain gages provides redundant instrumentation. If required, the preload on the conductors can be increased remotely by a special wrench attached to the clamp assembly.

  5. Inhibition of Hsp27 Radiosensitizes Head-and-Neck Cancer by Modulating Deoxyribonucleic Acid Repair

    SciTech Connect (OSTI)

    Guttmann, David M.; Hart, Lori; Du, Kevin; Seletsky, Andrew; Koumenis, Constantinos

    2013-09-01

    Purpose: To present a novel method of tumor radiosensitization through Hsp27 knockdown using locked nucleic acid (LNA) and to investigate the role of Hsp27 in DNA double strand break (DSB) repair. Methods and Materials: Clonogenic survival assays, immunoblotting, the proximity ligation assay, and ?H2AX foci analysis were conducted in SQ20B and FaDu human head-and-neck cancer cell lines treated with Hsp27 LNA and Hsp27 short hairpin RNA (shRNA). Additionally, nude mice with FaDu flank tumors were treated with fractionated radiation therapy after pretreatment with Hsp27 LNA and monitored for tumor growth. Results: Hsp27 LNA and Hsp27 shRNA radiosensitized head-and-neck cancer cell lines in an Hsp27-dependent manner. Ataxia-Telangectasia Mutated-mediated DNA repair signaling was impaired in irradiated cells with Hsp27 knockdown. ATM kinase inhibition abrogated the radiosensitizing effect of Hsp27. Furthermore, Hsp27 LNA and shRNA both attenuated DNA repair kinetics after radiation, and Hsp27 was found to colocalize with ATM in both untreated and irradiated cells. Last, combined radiation and Hsp27 LNA treatment in tumor xenografts in nude mice suppressed tumor growth compared with either treatment alone. Conclusions: These results support a radiosensitizing property of Hsp27 LNA in vitro and in vivo, implicate Hsp27 in double strand break repair, and suggest that Hsp27 LNA might eventually serve as an effective clinical agent in the radiotherapy of head-and-neck cancer.

  6. Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency

    SciTech Connect (OSTI)

    Barnhoorn, Sander; Uittenboogaard, Lieneke M.; Jaarsma, Dick; Vermeij, Wilbert P.; Tresini, Maria; Weymaere, Michael; Menoni, Hervé; Brandt, Renata M. C.; de Waard, Monique C.; Botter, Sander M.; Sarker, Altaf H.; Jaspers, Nicolaas G. J.; van der Horst, Gijsbertus T. J.; Cooper, Priscilla K.; Hoeijmakers, Jan H. J.; van der Pluijm, Ingrid; Niedernhofer, Laura J.

    2014-10-09

    As part of the Nucleotide Excision Repair (NER) process, the endonuclease XPG is involved in repair of helix-distorting DNA lesions, but the protein has also been implicated in several other DNA repair systems, complicating genotype-phenotype relationship in XPG patients. Defects in XPG can cause either the cancer-prone condition xeroderma pigmentosum (XP) alone, or XP combined with the severe neurodevelopmental disorder Cockayne Syndrome (CS), or the infantile lethal cerebro-oculo-facio-skeletal (COFS) syndrome, characterized by dramatic growth failure, progressive neurodevelopmental abnormalities and greatly reduced life expectancy. Here, we present a novel (conditional) Xpg-/- mouse model which—in a C57BL6/FVB F1 hybrid genetic background—displays many progeroid features, including cessation of growth, loss of subcutaneous fat, kyphosis, osteoporosis, retinal photoreceptor loss, liver aging, extensive neurodegeneration, and a short lifespan of 4–5 months. We show that deletion of XPG specifically in the liver reproduces the progeroid features in the liver, yet abolishes the effect on growth or lifespan. In addition, specific XPG deletion in neurons and glia of the forebrain creates a progressive neurodegenerative phenotype that shows many characteristics of human XPG deficiency. Our findings therefore exclude that both the liver as well as the neurological phenotype are a secondary consequence of derailment in other cell types, organs or tissues (e.g. vascular abnormalities) and support a cell-autonomous origin caused by the DNA repair defect itself. In addition they allow the dissection of the complex aging process in tissue- and cell-type-specific components. Moreover, our data highlight the critical importance of genetic background in mouse aging studies, establish the Xpg-/- mouse as a valid model for the severe form of human XPG patients and segmental accelerated aging, and strengthen the link between DNA damage and aging.

  7. Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Barnhoorn, Sander; Uittenboogaard, Lieneke M.; Jaarsma, Dick; Vermeij, Wilbert P.; Tresini, Maria; Weymaere, Michael; Menoni, Hervé; Brandt, Renata M. C.; de Waard, Monique C.; Botter, Sander M.; et al

    2014-10-09

    As part of the Nucleotide Excision Repair (NER) process, the endonuclease XPG is involved in repair of helix-distorting DNA lesions, but the protein has also been implicated in several other DNA repair systems, complicating genotype-phenotype relationship in XPG patients. Defects in XPG can cause either the cancer-prone condition xeroderma pigmentosum (XP) alone, or XP combined with the severe neurodevelopmental disorder Cockayne Syndrome (CS), or the infantile lethal cerebro-oculo-facio-skeletal (COFS) syndrome, characterized by dramatic growth failure, progressive neurodevelopmental abnormalities and greatly reduced life expectancy. Here, we present a novel (conditional) Xpg-/- mouse model which—in a C57BL6/FVB F1 hybrid genetic background—displays manymore » progeroid features, including cessation of growth, loss of subcutaneous fat, kyphosis, osteoporosis, retinal photoreceptor loss, liver aging, extensive neurodegeneration, and a short lifespan of 4–5 months. We show that deletion of XPG specifically in the liver reproduces the progeroid features in the liver, yet abolishes the effect on growth or lifespan. In addition, specific XPG deletion in neurons and glia of the forebrain creates a progressive neurodegenerative phenotype that shows many characteristics of human XPG deficiency. Our findings therefore exclude that both the liver as well as the neurological phenotype are a secondary consequence of derailment in other cell types, organs or tissues (e.g. vascular abnormalities) and support a cell-autonomous origin caused by the DNA repair defect itself. In addition they allow the dissection of the complex aging process in tissue- and cell-type-specific components. Moreover, our data highlight the critical importance of genetic background in mouse aging studies, establish the Xpg-/- mouse as a valid model for the severe form of human XPG patients and segmental accelerated aging, and strengthen the link between DNA damage and aging.« less

  8. Quality Improvement Guidelines for Imaging Detection and Treatment of Endoleaks following Endovascular Aneurysm Repair (EVAR)

    SciTech Connect (OSTI)

    Rand, T.; Uberoi, R.; Cil, B.; Munneke, G.; Tsetis, D.

    2013-02-15

    Major concerns after aortic aneurysm repair are caused by the presence of endoleaks, which are defined as persistent perigraft flow within the aortic aneurysm sac. Diagnosis of endoleaks can be performed with various imaging modalities, and indications for treatment are based on further subclassifications. Early detection and correct classification of endoleaks are crucial for planning patient management. The vast majority of endoleaks can be treated successfully by interventional means. Guidelines for Imaging Detection and Treatment of endoleaks are described in this article.

  9. Laser-activated nano-biomaterials for tissue repair and controlled drug release

    SciTech Connect (OSTI)

    Matteini, P; Ratto, F; Rossi, F; Pini, R

    2014-07-31

    We present recent achievements of minimally invasive welding of biological tissue and controlled drug release based on laser-activated nano-biomaterials. In particular, we consider new advancements in the biomedical application of near-IR absorbing gold nano-chromophores as an original solution for the photothermal repair of surgical incisions and as nanotriggers of controlled drug release from hybrid biopolymer scaffolds. (laser biophotonics)

  10. Inconsistent Investment and Consumption Problems

    SciTech Connect (OSTI)

    Kronborg, Morten Tolver; Steffensen, Mogens

    2015-06-15

    In a traditional Black–Scholes market we develop a verification theorem for a general class of investment and consumption problems where the standard dynamic programming principle does not hold. The theorem is an extension of the standard Hamilton–Jacobi–Bellman equation in the form of a system of non-linear differential equations. We derive the optimal investment and consumption strategy for a mean-variance investor without pre-commitment endowed with labor income. In the case of constant risk aversion it turns out that the optimal amount of money to invest in stocks is independent of wealth. The optimal consumption strategy is given as a deterministic bang-bang strategy. In order to have a more realistic model we allow the risk aversion to be time and state dependent. Of special interest is the case were the risk aversion is inversely proportional to present wealth plus the financial value of future labor income net of consumption. Using the verification theorem we give a detailed analysis of this problem. It turns out that the optimal amount of money to invest in stocks is given by a linear function of wealth plus the financial value of future labor income net of consumption. The optimal consumption strategy is again given as a deterministic bang-bang strategy. We also calculate, for a general time and state dependent risk aversion function, the optimal investment and consumption strategy for a mean-standard deviation investor without pre-commitment. In that case, it turns out that it is optimal to take no risk at all.

  11. ASTRID sodium cooled fast reactor: Program for improving in service inspection and repair

    SciTech Connect (OSTI)

    Jadot, F.; De Dinechin, G.; Augem, J. M.; Sibilo, J.

    2011-07-01

    In the frame of the CEA, EDF, AREVA coordinated research program for the development of Generation IV sodium-cooled fast reactors (SFR), the ASTRID project was launched in 2010. For the future prototype, the improvement of in-service inspection and repair (ISI and R) capabilities was identified as a major issue. Following the pluri-annual SFR research program, the ISI and R main R and D axes remain: i) improvement of the primary system conceptual design, ii) development of measurement and inspection techniques (continuous monitoring instrumentation and periodic inspection tools), iii) accessibility and associated robotics, and iv) development and validation of repair processes. Associated ISI and R needs are being defined through an iterative method between designers and instrumentation specialists: adaptation of the Design to ISI and R requirements, fission chamber development, validation of the ultrasonic and chemical transducers, of ultrasonic non destructive simulation, of acoustic surveillance, of laser repair intervention processes, of connected robotic equipment. Moreover, CEA, as leader of the ASTRID Project, is willing to find new contributors, partners or suppliers, in order to get innovative, diversified, exhaustive and efficient solutions. (authors)

  12. ACOUSTICAL IMAGING AND MECHANICAL PROPERTIES OF SOFT ROCK AND MARINE SEDIMENTS

    SciTech Connect (OSTI)

    Thurman E. Scott, Jr., Ph.D.; Musharraf Zaman, Ph.D.; Younane Abousleiman, Ph.D.

    2001-04-01

    The oil and gas industry has encountered significant problems in the production of oil and gas from weak rocks (such as chalks and limestones) and from unconsolidated sand formations. Problems include subsidence, compaction, sand production, and catastrophic shallow water sand flows during deep water drilling. Together these cost the petroleum industry hundreds of millions of dollars annually. The goals of this first quarterly report is to document the progress on the project to provide data on the acoustic imaging and mechanical properties of soft rock and marine sediments. The project is intended to determine the geophysical (acoustic velocities) rock properties of weak, poorly cemented rocks and unconsolidated sands. In some cases these weak formations can create problems for reservoir engineers. For example, it cost Phillips Petroleum 1 billion dollars to repair of offshore production facilities damaged during the unexpected subsidence and compaction of the Ekofisk Field in the North Sea (Sulak 1991). Another example is the problem of shallow water flows (SWF) occurring in sands just below the seafloor encountered during deep water drilling operations. In these cases the unconsolidated sands uncontrollably flow up around the annulus of the borehole resulting in loss of the drill casing. The $150 million dollar loss of the Ursa development project in the U.S. Gulf Coast resulted from an uncontrolled SWF (Furlow 1998a,b; 1999a,b). The first three tasks outlined in the work plan are: (1) obtain rock samples, (2) construct new acoustic platens, (3) calibrate and test the equipment. These have been completed as scheduled. Rock Mechanics Institute researchers at the University of Oklahoma have obtained eight different types of samples for the experimental program. These include: (a) Danian Chalk, (b) Cordoba Cream Limestone, (c) Indiana Limestone, (d) Ekofisk Chalk, (e) Oil Creek Sandstone, (f) unconsolidated Oil Creek sand, and (g) unconsolidated Brazos river sand

  13. Relationship of DNA repair processes to mutagenesis and carcinogenesis in mammalian cells. Progress report, August 1, 1977-October 31, 1980

    SciTech Connect (OSTI)

    Evans, H.H.

    1980-10-01

    The objective of this research is to determine the role of DNA repair in mutagenesis and carcinogenesis in mammalian cells. More specifically, mutant strains will be selected which are deficient in various DNA repair pathways. These strains will be studied with regard to (1) the nature of the defect in repair, and (2) the mutability and transformability of the defective cells by various agents as compared to the wild type parental cells. The results to date include progress in the following areas: (1) determination of optimum conditions for growth and maintenance of cells and for quantitative measurement of various cellular parameters; (2) investigation of the effect of holding mutagenized cells for various periods in a density inhibited state on survival and on mutation and transformation frequencies; (3) examination of the repair capabilities of BHK cells, as compared to repair-proficient and repair-deficient human cells and excision-deficient mouse cells, as measured by the reactivation of Herpes simplex virus (HSV) treated with radiation and ethylmethane sulfonate (EMS); (4) initiation of host cell reactivation viral sucide enrichment and screening of survivors of the enrichment for sensitivity to ionizing radiation; and (5) investigation of the toxicity, mutagenicity, and carcinogenicity of various metabolites of 4-nitroquinoline-1-oxide (4-NQO). (ERB)

  14. Enhancements of branch and bound methods for the maximal constraint satisfaction problem

    SciTech Connect (OSTI)

    Wallace, R.J.

    1996-12-31

    Two methods are described for enhancing performance of branch and bound methods for overconstrained CSPs. These methods improve either the upper or lower bound, respectively, during search, so the two can be combined. Upper bounds are improved by using heuristic repair methods before search to find a good solution quickly, whose cost is used as the initial upper bound. The method for improving lower bounds is an extension of directed arc consistency preprocessing, used in conjunction with forward checking. After computing directed arc consistency counts, inferred counts are computed for all values based on minimum counts for values of adjacent variables that are later in the search order. This inference process can be iterated, so that counts are cascaded from the end to the beginning of the search order, to augment the initial counts. Improvements in time and effort are demonstrated for both techniques using random problems.

  15. HYDRAULIC SERVO CONTROL MECHANISM

    DOE Patents [OSTI]

    Hussey, R.B.; Gottsche, M.J. Jr.

    1963-09-17

    A hydraulic servo control mechanism of compact construction and low fluid requirements is described. The mechanism consists of a main hydraulic piston, comprising the drive output, which is connected mechanically for feedback purposes to a servo control piston. A control sleeve having control slots for the system encloses the servo piston, which acts to cover or uncover the slots as a means of controlling the operation of the system. This operation permits only a small amount of fluid to regulate the operation of the mechanism, which, as a result, is compact and relatively light. This mechanism is particuiarly adaptable to the drive and control of control rods in nuclear reactors. (auth)

  16. Mechanical seal assembly

    DOE Patents [OSTI]

    Kotlyar, Oleg M.

    2001-01-01

    An improved mechanical seal assembly is provided for sealing rotating shafts with respect to their shaft housings, wherein the rotating shafts are subject to substantial axial vibrations. The mechanical seal assembly generally includes a rotating sealing ring fixed to the shaft, a non-rotating sealing ring adjacent to and in close contact with the rotating sealing ring for forming an annular seal about the shaft, and a mechanical diode element that applies a biasing force to the non-rotating sealing ring by means of hemispherical joint. The alignment of the mechanical diode with respect to the sealing rings is maintained by a series of linear bearings positioned axially along a desired length of the mechanical diode. Alternative embodiments include mechanical or hydraulic amplification components for amplifying axial displacement of the non-rotating sealing ring and transferring it to the mechanical diode.

  17. Mechanical seal assembly

    DOE Patents [OSTI]

    Kotlyar, Oleg M.

    2002-01-01

    An improved mechanical seal assembly is provided for sealing rotating shafts with respect to their shaft housings, wherein the rotating shafts are subject to substantial axial vibrations. The mechanical seal assembly generally includes a rotating sealing ring fixed to the shaft, a non-rotating sealing ring adjacent to and in close contact with the rotating sealing ring for forming an annular seal about the shaft, and a mechanical diode element that applies a biasing force to the non-rotating sealing ring by means of hemispherical joint. The alignment of the mechanical diode with respect to the sealing rings is maintained by a series of linear bearings positioned axially along a desired length of the mechanical diode. Alternative embodiments include mechanical or hydraulic amplification components for amplifying axial displacement of the non-rotating sealing ring and transfering it to the mechanical diode.

  18. Fusion, mechanical joining methods pros, cons--Part 2. [Natural gas pipelines use of mechanical and fusion joints

    SciTech Connect (OSTI)

    Gunther, K.M. )

    1993-10-01

    Two basic techniques accepted by gas distribution utility companies for joining polyethylene pipe underground are fusion methods and mechanical joining. Washington Gas Light Co., uses the fusion methods for the most part and uses mechanical joints for repair and final tie-ins where fusion methods are impractical or impossible to use. Fusion methods used by gas industry users of plastic pipe are: butt fusion; socket fusion; saddle fusion; electrofusion. Mechanical pipe joining techniques or procedures include: factory made mechanical joints such as meter risers and transition fittings; hydraulic compression couplings; bolted and screwed compression couplings; stab type compression couplings; interior seal couplings. Every joining method has strengths, weaknesses, pitfalls and ways they can fail in service. The key is making the best selection based on such factors as location, temperature, conditions, available equipment, personnel training level and cost. No one method will do it all or every company would be using that particular method. Part 2 focuses on strengths, weaknesses, pitfalls and failure possibilities of the five mechanical techniques.

  19. Development and validation of nondestructive inspection techniques for composite doubler repairs on commercial aircraft

    SciTech Connect (OSTI)

    Roach, D.; Walkington, P.

    1998-05-01

    Composite doublers, or repair patches, provide an innovative repair technique which can enhance the way aircraft are maintained. Instead of riveting multiple steel or aluminum plates to facilitate an aircraft repair, it is possible to bond a single boron-epoxy composite doubler to the damaged structure. In order for the use of composite doublers to achieve widespread use in the civil aviation industry, it is imperative that methods be developed which can quickly and reliably assess the integrity of the doubler. In this study, a specific composite application was chosen on an L-1011 aircraft in order to focus the tasks on application and operation issues. Primary among inspection requirements for these doublers is the identification of disbonds, between the composite laminate and aluminum parent material, and delaminations in the composite laminate. Surveillance of cracks or corrosion in the parent aluminum material beneath the doubler is also a concern. No single nondestructive inspection (NDI) method can inspect for every flaw type, therefore it is important to be aware of available NDI techniques and to properly address their capabilities and limitations. A series of NDI tests were conducted on laboratory test structures and on full-scale aircraft fuselage sections. Specific challenges, unique to bonded composite doubler applications, were highlighted. An array of conventional and advanced NDI techniques were evaluated. Flaw detection sensitivity studies were conducted on applicable eddy current, ultrasonic, X-ray and thermography based devices. The application of these NDI techniques to composite doublers and the results from test specimens, which were loaded to provide a changing flaw profile, are presented in this report. It was found that a team of these techniques can identify flaws in composite doubler installations well before they reach critical size.

  20. Computational Structural Mechanics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    load-2 TRACC RESEARCH Computational Fluid Dynamics Computational Structural Mechanics Transportation Systems Modeling Computational Structural Mechanics Overview of CSM Computational structural mechanics is a well-established methodology for the design and analysis of many components and structures found in the transportation field. Modern finite-element models (FEMs) play a major role in these evaluations, and sophisticated software, such as the commercially available LS-DYNA® code, is

  1. JAG Tearing Technique with Radiofrequency Guide Wire for Aortic Fenestration in Thoracic Endovascular Aneurysm Repair

    SciTech Connect (OSTI)

    Ricci, Carmelo; Ceccherini, Claudio Leonini, Sara; Cini, Marco; Vigni, Francesco; Neri, Eugenio; Tucci, Enrico; Benvenuti, Antonio; Tommasino, Giulio; Sassi, Carlo

    2012-02-15

    An innovative approach, the JAG tearing technique, was performed during thoracic endovascular aneurysm repair in a patient with previous surgical replacement of the ascending aorta with a residual uncomplicated type B aortic dissection who developed an aneurysm of the descending thoracic aorta with its lumen divided in two parts by an intimal flap. The proximal landing zone was suitable to place a thoracic stent graft. The distal landing zone was created by cutting the intimal flap in the distal third of the descending thoracic aorta with a radiofrequency guide wire and intravascular ultrasound catheter.

  2. Failures and repairs of headers and drums in fossil fired boilers

    SciTech Connect (OSTI)

    Thielsch, H.; Cone, F.

    1995-12-01

    This paper discusses failures which have occurred in a number of thick-walled pressure vessels including superheater and reheat outlet headers, and med and steam drums in fossil fired boilers. It provides details regarding the causes of failure, which range from original manufacturing defects to service-related deterioration such as creep and thermal fatigue. It also provides information regarding inspection techniques which are capable of detecting similar conditions before they have reached dangerous levels of deterioration. Finally, it provides details pertaining to techniques used to successfully repair these pressure vessels when they have failed.

  3. Heavy Mobile Equipment Mechanic

    Broader source: Energy.gov [DOE]

    Join the Bonneville Power Administration (BPA) for a challenging and rewarding career, while working, living, and playing in the Pacific Northwest. The Heavy Mobile Equipment Mechanic (HMEM)...

  4. Determination of Mechanical Properties

    Office of Scientific and Technical Information (OSTI)

    ... Monofilament Laminates," paper 61-AV56 presented at American Society of Mechanical Engineers Aviation Conference, Los Angeles, California (March 1961). 21. G. S. Springer and s. ...

  5. Monroe Thomas, Mechanical Technician

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and endstation moves. Though he's training another mechanical technician to operate the crane, it's Monroe who is called upon for critical moves. He plays a key role in...

  6. Structure of DNA-Bound FEN1 Reveals Mechanism of Action

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    50 million times without introducing any errors. But FEN1 is also important in DNA repair, targeting specific repair pathways, which presents different challenges than...

  7. Plugging mechanisms in a lost circulation model

    SciTech Connect (OSTI)

    Givler, R.C.

    1985-01-01

    The problem of lost circulation during the drilling of geothermal wells is recognized to be a serious impediment to well completion. A viable solution, in terms of an ''engineered'' plugging material, will be enhanced via analytical cognizance of possible down-hole plugging mechanisms. This paper investigates several plugging strategies that result from rudimentary, mathematical models of the mud rheology (with and without dispersed particulate). 10 refs., 7 figs.

  8. Student's algorithm solves real-world problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Student's algorithm solves real-world problem Supercomputing Challenge: student's algorithm solves real-world problem Students learn how to use powerful computers to analyze, model, and solve real-world problems. April 3, 2012 Jordon Medlock of Albuquerque's Manzano High School won the 2012 Lab-sponsored Supercomputing Challenge Jordon Medlock of Albuquerque's Manzano High School won the 2012 Lab-sponsored Supercomputing Challenge by creating a computer algorithm that automates the process of

  9. Approximate resolution of hard numbering problems

    SciTech Connect (OSTI)

    Bailleux, O.; Chabrier, J.J.

    1996-12-31

    We present a new method for estimating the number of solutions of constraint satisfaction problems. We use a stochastic forward checking algorithm for drawing a sample of paths from a search tree. With this sample, we compute two values related to the number of solutions of a CSP instance. First, an unbiased estimate, second, a lower bound with an arbitrary low error probability. We will describe applications to the Boolean Satisfiability problem and the Queens problem. We shall give some experimental results for these problems.

  10. design problem | OpenEI Community

    Open Energy Info (EERE)

    design problem Home Dc's picture Submitted by Dc(266) Contributor 15 November, 2013 - 13:26 Living Walls ancient building system architect biomimicry building technology cooling cu...

  11. PCx: Optimization Problem Solver | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    programming problems. Windows 95 version includes a user-friendly graphical interface Java graphical interface is available for all environments Source code is available and...

  12. Statewide Power Problems May Affect SSRL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Statewide Power Problems May Affect SSRL The power crisis affecting California and the northwestern US may have some implication for SSRL users during the current run. As the...

  13. Engineering report standard hydrogen monitoring system problems

    SciTech Connect (OSTI)

    Golberg, R.L.

    1996-09-25

    Engineering Report to document moisture problems found during the sampling of the vapors in the dome space for hydrogen in the storage tanks and a recommended solution.

  14. Frequency Instability Problems in North American Interconnections

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Instability Problems in North American Interconnections Prepared by: Energy Sector Planning and Analysis (ESPA) ... would make the situation worse during an emergency event. ...

  15. Mechanical code comparator

    DOE Patents [OSTI]

    Peter, Frank J.; Dalton, Larry J.; Plummer, David W.

    2002-01-01

    A new class of mechanical code comparators is described which have broad potential for application in safety, surety, and security applications. These devices can be implemented as micro-scale electromechanical systems that isolate a secure or otherwise controlled device until an access code is entered. This access code is converted into a series of mechanical inputs to the mechanical code comparator, which compares the access code to a pre-input combination, entered previously into the mechanical code comparator by an operator at the system security control point. These devices provide extremely high levels of robust security. Being totally mechanical in operation, an access control system properly based on such devices cannot be circumvented by software attack alone.

  16. Effect of thermo-mechanical treatment on mechanical and elastic...

    Office of Scientific and Technical Information (OSTI)

    Effect of thermo-mechanical treatment on mechanical and elastic properties of Ti-36Nb-5Zr alloy Title: Effect of thermo-mechanical treatment on mechanical and elastic properties of ...

  17. The {open_quotes}first{close_quotes} problem

    SciTech Connect (OSTI)

    Holsinger, R.F.

    1995-02-01

    This paper describes the first magnet design problem that Klaus and the author worked on together. At the time, over 30 years ago, Klaus was working as a plasma physicist in the Controlled Thermonuclear Research (CTR) Group, and the author was assigned from the Mechanical Engineering Department to help with the design of experimental equipment for various research projects. Klaus` primary research program was to develop a {open_quotes}plasma gun{close_quotes} for injecting plasma into {open_quotes}mirror machines.{close_quotes} As described, the magnet design aspect of this plasma gun was a challenging task, and led to some innovations that were quite advanced at that time.

  18. A Branch and Bound Approach for Truss Topology Design Problems with Valid Inequalities

    SciTech Connect (OSTI)

    Cerveira, Adelaide; Agra, Agostinho; Bastos, Fernando; Varum, Humberto

    2010-09-30

    One of the classical problems in the structural optimization field is the Truss Topology Design Problem (TTDP) which deals with the selection of optimal configuration for structural systems for applications in mechanical, civil, aerospace engineering, among others. In this paper we consider a TTDP where the goal is to find the stiffest truss, under a given load and with a bound on the total volume. The design variables are the cross-section areas of the truss bars that must be chosen from a given finite set. This results in a large-scale non-convex problem with discrete variables. This problem can be formulated as a Semidefinite Programming Problem (SDP problem) with binary variables. We propose a branch and bound algorithm to solve this problem. In this paper it is considered a binary formulation of the problem, to take advantage of its structure, which admits a Knapsack problem as subproblem. Thus, trying to improve the performance of the Branch and Bound, at each step, some valid inequalities for the Knapsack problem are included.

  19. Specification of the Advanced Burner Test Reactor Multi-Physics Coupling Demonstration Problem

    SciTech Connect (OSTI)

    Shemon, E. R.; Grudzinski, J. J.; Lee, C. H.; Thomas, J. W.; Yu, Y. Q.

    2015-12-21

    This document specifies the multi-physics nuclear reactor demonstration problem using the SHARP software package developed by NEAMS. The SHARP toolset simulates the key coupled physics phenomena inside a nuclear reactor. The PROTEUS neutronics code models the neutron transport within the system, the Nek5000 computational fluid dynamics code models the fluid flow and heat transfer, and the DIABLO structural mechanics code models structural and mechanical deformation. The three codes are coupled to the MOAB mesh framework which allows feedback from neutronics, fluid mechanics, and mechanical deformation in a compatible format.

  20. Tsirelson's problem and asymptotically commuting unitary matrices...

    Office of Scientific and Technical Information (OSTI)

    Language: English Subject: 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; 97 MATHEMATICAL METHODS AND COMPUTING; ALGEBRA; CORRELATIONS; INTERACTIONS; MATRICES; UNITARY ...

  1. Experimental studies of a quantum-mechanical three-body problem

    Office of Scientific and Technical Information (OSTI)

    ... Harris, H. C. Bryant, A. H. Mohagheghi, R. A. Reeder, H. Sharifian, C. Y. Tang, H. Tootoonchi, J. B. Donahue, C. R. Quick, D. C. Rislove, W. W. Smith, and J. E. Stewart, Phys. Rev. ...

  2. Planning and care mark repair of 14-year old leak in Kuwait Oil Co. LPG tank 95

    SciTech Connect (OSTI)

    Shtayieh, S.

    1983-01-10

    This paper points out that the leak, which had been present for such a long time, completely saturated the perlite insulation with hydrocarbons, thus rendering the entire operation of inspection, repair, and maintenance of the inner tank a hazardous operation. It emphasizes the safety aspects, which were complicated by the saturated perlite as well as by the fact that the tank is situated in the middle of the LPG storage area with LPG tanks on either side. Tank design, making preparations, inspection, and repair are discussed. The fact that the leaking flanges were originally installed damaged, indicated the future need of tighter company quality control of all contractors work.

  3. Operational results of shaft repair by installing stave type cooler at Kimitsu Nos. 3 and 4 blast furnaces

    SciTech Connect (OSTI)

    Oda, Hiroshi; Amano, Shigeru; Sakamoto, Aiichiro; Anzai, Osamu; Nakagome, Michiru; Kuze, Toshisuke; Imuta, Akira

    1997-12-31

    Nos. 3 and 4 blast furnaces in Nippon Steel Corporation Kimitsu Works were both initially fitted with cooling plate systems. With the aging of each furnace, the damage to their respective inner-shaft profiles had become serious. Thus, in order to prevent operational change and prolong the furnace life, the inner-shaft profile of each furnace was repaired by replacing the former cooling plate system with the stave type cooler during the two-week-shutdowns. With this repair, stability of burden descent and gas flow near the wall part of the furnace have been achieved. Thus the prolongation of the furnace life is naturally expected.

  4. AMRH and High Energy Reinicke Problem

    SciTech Connect (OSTI)

    Shestakov, A I; Greenough, J A

    2001-05-14

    The authors describe AMRH results on a version of the Reinicke problem specified by the V and V group of LLNL's A-Div. The simulation models a point explosion with heat conduction. The problem specification requires that the heat conduction be replaced with diffusive radiation transport. The matter and radiation energy densities are tightly coupled.

  5. Integrated network design and scheduling problems :

    SciTech Connect (OSTI)

    Nurre, Sarah G.; Carlson, Jeffrey J.

    2014-01-01

    We consider the class of integrated network design and scheduling problems. These problems focus on selecting and scheduling operations that will change the characteristics of a network, while being speci cally concerned with the performance of the network over time. Motivating applications of INDS problems include infrastructure restoration after extreme events and building humanitarian distribution supply chains. While similar models have been proposed, no one has performed an extensive review of INDS problems from their complexity, network and scheduling characteristics, information, and solution methods. We examine INDS problems under a parallel identical machine scheduling environment where the performance of the network is evaluated by solving classic network optimization problems. We classify that all considered INDS problems as NP-Hard and propose a novel heuristic dispatching rule algorithm that selects and schedules sets of arcs based on their interactions in the network. We present computational analysis based on realistic data sets representing the infrastructures of coastal New Hanover County, North Carolina, lower Manhattan, New York, and a realistic arti cial community CLARC County. These tests demonstrate the importance of a dispatching rule to arrive at near-optimal solutions during real-time decision making activities. We extend INDS problems to incorporate release dates which represent the earliest an operation can be performed and exible release dates through the introduction of specialized machine(s) that can perform work to move the release date earlier in time. An online optimization setting is explored where the release date of a component is not known.

  6. Electronic door locking mechanism

    DOE Patents [OSTI]

    Williams, Gary Lin; Kirby, Patrick Gerald

    1997-01-01

    The invention is a motorized linkage for engaging a thumb piece in a door mechanism. The device has an exterior lock assembly with a small battery cell and combination lock. Proper entry by a user of a security code allows the battery to operate a small motor within the exterior lock assembly. The small motor manipulates a cam-plunger which moves an actuator pin into a thumb piece. The user applies a force on to the thumb piece. This force is transmitted by the thumb piece to a latch engagement mechanism by the actuator pin. The latch engagement mechanism operates the door latch.

  7. Electronic door locking mechanism

    DOE Patents [OSTI]

    Williams, G.L.; Kirby, P.G.

    1997-10-21

    The invention is a motorized linkage for engaging a thumb piece in a door mechanism. The device has an exterior lock assembly with a small battery cell and combination lock. Proper entry by a user of a security code allows the battery to operate a small motor within the exterior lock assembly. The small motor manipulates a cam-plunger which moves an actuator pin into a thumb piece. The user applies a force on to the thumb piece. This force is transmitted by the thumb piece to a latch engagement mechanism by the actuator pin. The latch engagement mechanism operates the door latch. 6 figs.

  8. Rotary mechanical latch

    SciTech Connect (OSTI)

    Spletzer, Barry L.; Martinez, Michael A.; Marron, Lisa C.

    2012-11-13

    A rotary mechanical latch for positive latching and unlatching of a rotary device with a latchable rotating assembly having a latching gear that can be driven to latched and unlatched states by a drive mechanism such as an electric motor. A cam arm affixed to the latching gear interfaces with leading and trailing latch cams affixed to a flange within the drive mechanism. The interaction of the cam arm with leading and trailing latch cams prevents rotation of the rotating assembly by external forces such as those due to vibration or tampering.

  9. Renewable Auction Mechanism (RAM)

    Broader source: Energy.gov [DOE]

    The Renewable Auction Mechanism (RAM) was approved by the California Public Utilities Commission (CPUC) in December 2010 with a goal of installing 1,500 megawatts (MW) of new distributed generation...

  10. Failure mechanisms in MEMS.

    SciTech Connect (OSTI)

    Walraven, Jeremy Allen

    2003-07-01

    MEMS components by their very nature have different and unique failure mechanisms than their macroscopic counterparts. This paper discusses failure mechanisms observed in various MEMS components and technologies. MEMS devices fabricated using bulk and surface micromachining process technologies are emphasized. MEMS devices offer uniqueness in their application, fabrication, and functionality. Their uniqueness creates various failure mechanisms not typically found in their bulk or IC counterparts. In ICs, electrical precautions are taken to mitigate failure. In MEMS, both electrical and mechanical precautions must be enacted to reduce the risk of failure and increased reliability. Unlike ICs, many MEMS components are designed to interact with their environment, making the fabrication, testing, and packaging processes critical for the success of the device.