Sample records for mechanical problems repairs

  1. Effect of multiple repairs in girth welds of pipelines on the mechanical properties

    SciTech Connect (OSTI)

    Vega, O.E.; Hallen, J.M. [Departamento de Ingenieria Metalurgica, ESIQIE-IPN, Laboratorios Pesados de Metalurgia, UPALM, Zacatenco, C.P. 07738, Mexico D.F. (Mexico); Villagomez, A. [Construcciones Maritimas Mexicanas, CMM-PROTEXA, Av. Periferica s/n, Fracc. Lomas de Holche, C.P. 24120, Cd. del Carmen, Campeche (Mexico); Contreras, A. [Instituto Mexicano del Petroleo, Investigacion en Ductos, Corrosion y Materiales, Eje Central Lazaro Cardenas Norte 152 Col. San Bartolo Atepehuacan, C.P. 07730, Mexico D.F. (Mexico)], E-mail: acontrer@imp.mx

    2008-10-15T23:59:59.000Z

    This work presents the results of multiple weld repairs in the same area in seamless API X-52 microalloyed steel pipe. Four conditions of shielded metal arc welding repairs and one as-welded specimen of the girth weld were characterized to determine changes in the microstructure, grain size in the heat affected zone, and to evaluate their effect on the mechanical properties of the weld joints. The mechanical properties by means of tension tests, Charpy-V impact resistance and Vickers hardness of the welds were analyzed. The results indicate that significant changes are not generated in the microstructural constituents of the heat affected zone. Grain growth in the heat affected zone at the specimen mid-thickness with the number of repairs was observed. Tensile strength of the weld joints meets the requirement of the API 1104 standard even after the fourth weld repair. Significant reduction in Charpy-V impact resistance with the number of weld repairs was found when the notch location was in the intersection of the fusion line with the specimen mid-thickness. A significant increase in the Vickers hardness of the heat affected zone occurred after the first repair and a gradual decrease in the Vickers hardness occurred as the number of repairs increases.

  2. Mechanical engineering Mechanical engineering is about solving problems, designing processes,

    E-Print Network [OSTI]

    Waikato, University of

    the basic engineering sciences of thermal fluid science, separation processes, chemical reactions, unitMechanical engineering Mechanical engineering is about solving problems, designing processes, and making products to improve the quality of human life and shape the economy. Mechanical engineers apply

  3. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Bill Bruce; Nancy Porter; George Ritter; Matt Boring; Mark Lozev; Ian Harris; Bill Mohr; Dennis Harwig; Robin Gordon; Chris Neary; Mike Sullivan

    2005-07-20T23:59:59.000Z

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is only marginally effective at restoring the pressure containing capabilities of pipelines. Failure pressures for larger diameter pipe repaired with a semi-circular patch of carbon fiber-reinforced composite lines were also marginally greater than that of a pipe section with un-repaired simulated damage without a liner. These results indicate that fiber reinforced composite liners have the potential to increase the burst pressure of pipe sections with external damage Carbon fiber based liners are viewed as more promising than glass fiber based liners because of the potential for more closely matching the mechanical properties of steel. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. In lieu of a field installation on an abandoned pipeline, a preliminary nondestructive testing protocol is being developed to determine the success or failure of the fiber-reinforced liner pipeline repairs. Optimization and validation activities for carbon-fiber repair methods are ongoing.

  4. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

    2004-12-31T23:59:59.000Z

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is only marginally effective at restoring the pressure containing capabilities of pipelines. Failure pressures for larger diameter pipe repaired with a semi-circular patch of carbon fiber-reinforced composite lines were also marginally greater than that of a pipe section with un-repaired simulated damage without a liner. These results indicate that fiber reinforced composite liners have the potential to increase the burst pressure of pipe sections with external damage Carbon fiber based liners are viewed as more promising than glass fiber based liners because of the potential for more closely matching the mechanical properties of steel. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. The first round of optimization and validation activities for carbon-fiber repairs are complete. Development of a comprehensive test plan for this process is recommended for use in the field trial portion of this program.

  5. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

    2004-08-17T23:59:59.000Z

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Principal conclusions from a survey of natural gas transmission industry pipeline operators can be summarized in terms of the following performance requirements for internal repair: (1) Use of internal repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) The most common size range for 80% to 90% of operators surveyed is 508 mm (20 in.) to 762 mm (30 in.), with 95% using 558.8 mm (22 in.) pipe. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is only marginally effective at restoring the pressure containing capabilities of pipelines. Failure pressures for larger diameter pipe repaired with a semi-circular patch of carbon fiber-reinforced composite lines were also marginally greater than that of a pipe section with un-repaired simulated damage without a liner. These results indicate that fiber reinforced composite liners have the potential to increase the burst pressure of pipe sections with external damage Carbon fiber based liners are viewed as more promising than glass fiber based liners because of the potential for more closely matching the mechanical properties of steel. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. Development of a comprehensive test plan for this process is recommended for use in the field trial portion of this program.

  6. Advanced Statistical Mechanics: CHEM 646 Problem Set 1

    E-Print Network [OSTI]

    Ronis, David M.

    is a function of position, show that dI() d = d r I() ( r) ( r). Inverting the question, suppose weAdvanced Statistical Mechanics: CHEM 646 Problem Set 1 1. At low densities, the generic pair distribution function can be approximated as (2) ( r1, r2) = 2 e- u12(r12) , where u12 is the pair potential

  7. By unravelling some of the mechanisms of lung injury, repair and fibrosis, Professor Bruce D Uhal's collaborative research is opening up the potential development of novel pharmaceutics

    E-Print Network [OSTI]

    Liu, Taosheng

    By unravelling some of the mechanisms of lung injury, repair and fibrosis, Professor Bruce D Uhal the biological molecules important to the function of the lungs. I was attracted to physiology because the many in your laboratory? Research in my laboratory has shown that during lung injury, Type II cells begin

  8. Effects of Surgical Repair or Reconstruction on Radiocarpal Mechanics from Wrists with Scapholunate Ligament Injury

    E-Print Network [OSTI]

    Johnson, Joshua

    2013-05-31T23:59:59.000Z

    Osteoarthritis as a result of injury/trauma is a significant problem, and there is still a need to develop tools for evaluating joint injuries and the effectiveness of surgical treatments. For the wrist in particular, ...

  9. Comparison of problem model change mechanisms issued from CSP and TRIZ

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Comparison of problem model change mechanisms issued from CSP and TRIZ RRoollaanndd DDee GGuuiioo satisfaction problem (CSP), on the other hand. Keywords: over-constrained problems, dialectical methods issued from CSP and TRIZ 2 · a set of evaluation parameters, which represent the objective of the problem

  10. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; Nancy Porter; Mike Sullivan; Chris Neary

    2004-04-12T23:59:59.000Z

    The two broad categories of deposited weld metal repair and fiber-reinforced composite liner repair technologies were reviewed for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Preliminary test programs were developed for both deposited weld metal repair and for fiber-reinforced composite liner repair. Evaluation trials have been conducted using a modified fiber-reinforced composite liner provided by RolaTube and pipe sections without liners. All pipe section specimens failed in areas of simulated damage. Pipe sections containing fiber-reinforced composite liners failed at pressures marginally greater than the pipe sections without liners. The next step is to evaluate a liner material with a modulus of elasticity approximately 95% of the modulus of elasticity for steel. Preliminary welding parameters were developed for deposited weld metal repair in preparation of the receipt of Pacific Gas & Electric's internal pipeline welding repair system (that was designed specifically for 559 mm (22 in.) diameter pipe) and the receipt of 559 mm (22 in.) pipe sections from Panhandle Eastern. The next steps are to transfer welding parameters to the PG&E system and to pressure test repaired pipe sections to failure. A survey of pipeline operators was conducted to better understand the needs and performance requirements of the natural gas transmission industry regarding internal repair. Completed surveys contained the following principal conclusions: (1) Use of internal weld repair is most attractive for river crossings, under other bodies of water, in difficult soil conditions, under highways, under congested intersections, and under railway crossings. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling (HDD) when a new bore must be created to solve a leak or other problem. (3) Typical travel distances can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). All three groups require pig-based systems. A despooled umbilical system would suffice for the first two groups which represents 81% of survey respondents. The third group would require an onboard self-contained power unit for propulsion and welding/liner repair energy needs. (4) Pipe diameter sizes range from 50.8 mm (2 in.) through 1,219.2 mm (48 in.). The most common size range for 80% to 90% of operators surveyed is 508 mm to 762 mm (20 in. to 30 in.), with 95% using 558.8 mm (22 in.) pipe. An evaluation of potential repair methods clearly indicates that the project should continue to focus on the development of a repair process involving the use of GMAW welding and on the development of a repair process involving the use of fiber-reinforced composite liners.

  11. Mechanically equivalent elastic-plastic deformations and the problem of plastic spin David J. Steigmann1

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Mechanically equivalent elastic-plastic deformations and the problem of plastic spin David J author to receive correspondence (steigman@me.berkeley.edu) Abstract: The problem of plastic spin is phrased in terms of a notion of mechanical equivalence among local relaxed configurations of an elastic/plastic

  12. Multiscale treatment of mechanical contact problems involving thin polymeric layers

    E-Print Network [OSTI]

    of energy wasted because of friction, which occurs in particular between mechanical components such as gears, such as providing protective or fouling-resistant coatings for manufacturing [5, 7, 8]. Of special interest

  13. Electromagnetism-like Mechanism with Force Decay Rate Great Deluge for the Course Timetabling Problem

    E-Print Network [OSTI]

    McCollum, Barry

    Electromagnetism-like Mechanism with Force Decay Rate Great Deluge for the Course Timetabling called Electromagnetism-like mechanism with force decay rate great deluge algorithm for university course on these benchmark problems. Keywords: Electromagnetism-like mechanism, force decay rate great deluge, course

  14. The Measurement Problem and the Reduction Postulate of Quantum Mechanics

    E-Print Network [OSTI]

    Rodolfo Gambini

    1998-06-18T23:59:59.000Z

    It is well known, that the causal Schr\\"odinger evolution of a quantum state is not compatible with the reduction postulate, even when decoherence is taken into account. The violation of the causal evolution, introduced by the standard reduction postulate distinguishes certain systems (as the measurement devices), whose states are very close to statistical mixtures (as the ones resulting from the process of decoherence). In these systems, this violation has not any observable effect. In arbitrary quantum systems, the transition from the initial density matrix to a diagonal matrix predicted by the standard reduction postulate, would lead to a complete breakdown of the Schr\\"odinger evolution, and consequently would destroy all the predictive power of quantum mechanics. What we show here, is that there is a modified version of the postulate that allows to treat all the quantum mechanical systems on equal footing. The standard reduction postulate may be considered as a good approximation, useful for practical purposes, of this modified version which is consistent with the Schr\\"odinger evolution and via decoherence with the experimental results. Within this approach, the physical role played by the reduction postulate is as a tool for the computation of relative probabilities and consequently for the determination of the probabilities of consistent histories.

  15. Problem Type Problem Type Description Air Conditioning Air conditioner not working, leaking, etc

    E-Print Network [OSTI]

    Tennessee, University of

    Problem Type Problem Type Description Air Conditioning Air conditioner not working, leaking, etc, Microfridges Doors and Hardware Door repair/replace Lock, latch or hinge repair, key stuck; Lost or stolen key, repair or replace Shades/Blinds Window treatment - repair or replace Washer/Dryer Washer/Dryer repair

  16. INTERNAL REPAIR OF PIPELINES

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Nancy Porter; Mike Sullivan; Chris Neary

    2003-05-01T23:59:59.000Z

    The two broad categories of deposited weld metal repair and fiber-reinforced composite repair technologies were reviewed for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Preliminary test programs were developed for both deposited weld metal repairs and for fiber-reinforced composite repair. To date, all of the experimental work pertaining to the evaluation of potential repair methods has focused on fiber-reinforced composite repairs. Hydrostatic testing was also conducted on four pipeline sections with simulated corrosion damage: two with composite liners and two without.

  17. Rapid road repair vehicle

    DOE Patents [OSTI]

    Mara, Leo M. (Livermore, CA)

    1998-01-01T23:59:59.000Z

    Disclosed is a rapid road repair vehicle capable of moving over a surface to be repaired at near normal posted traffic speeds to scan for and find an the high rate of speed, imperfections in the pavement surface, prepare the surface imperfection for repair by air pressure and vacuum cleaning, applying a correct amount of the correct patching material to effect the repair, smooth the resulting repaired surface, and catalog the location and quality of the repairs for maintenance records of the road surface. The rapid road repair vehicle can repair surface imperfections at lower cost, improved quality, at a higher rate of speed than was was heretofor possible, with significantly reduced exposure to safety and health hazards associated with this kind of road repair activities in the past.

  18. Rapid road repair vehicle

    DOE Patents [OSTI]

    Mara, L.M.

    1998-05-05T23:59:59.000Z

    Disclosed is a rapid road repair vehicle capable of moving over a surface to be repaired at near normal posted traffic speeds to scan for and find at the high rate of speed, imperfections in the pavement surface, prepare the surface imperfection for repair by air pressure and vacuum cleaning, applying a correct amount of the correct patching material to effect the repair, smooth the resulting repaired surface, and catalog the location and quality of the repairs for maintenance records of the road surface. The rapid road repair vehicle can repair surface imperfections at lower cost, improved quality, at a higher rate of speed than was not heretofor possible, with significantly reduced exposure to safety and health hazards associated with this kind of road repair activities in the past. 2 figs.

  19. Statistical mechanics problem sheet 7 1. The main component of Venus's atmosphere, carbon dioxide, is a linear molecule

    E-Print Network [OSTI]

    Dettmann, Carl

    Statistical mechanics problem sheet 7 1. The main component of Venus's atmosphere, carbon dioxide and energy. Show that the system is non-extensive, and find the chemical potential at which system properties

  20. PROBLEMS

    E-Print Network [OSTI]

    In each of Problems 1 through 8, ?nd the general solution of the given differentiaI ..... (b) Let yatr) = —282'. yttr) = Mr) '+ 21/20). and no) = 2n (I) * Zyrtf) Are ysU).

  1. An engineering analysis of natural and biomimetic self-repair processes for solar energy harvesting

    E-Print Network [OSTI]

    Boghossian, Ardemis A. (Ardemis Anoush)

    2012-01-01T23:59:59.000Z

    Plants have evolved highly sophisticated mechanisms of self-repair to regenerate proteins that become photo-damaged over time. Key to this self-repair process is the reversible self-assembly of protein complexes, which is ...

  2. Development of bonded composite doublers for the repair of oil recovery equipment.

    SciTech Connect (OSTI)

    Roach, David W.; Rackow, Kirk A.

    2005-06-01T23:59:59.000Z

    An unavoidable by-product of a metallic structure's use is the appearance of crack and corrosion flaws. Economic barriers to the replacement of these structures have created an aging infrastructure and placed even greater demands on efficient and safe repair methods. In the past decade, an advanced composite repair technology has made great strides in commercial aviation use. Extensive testing and analysis, through joint programs between the Sandia Labs FAA Airworthiness Assurance Center and the aviation industry, have proven that composite materials can be used to repair damaged aluminum structure. Successful pilot programs have produced flight performance history to establish the durability of bonded composite patches as a permanent repair on commercial aircraft structures. With this foundation in place, this effort is adapting bonded composite repair technology to civil structures. The use of bonded composite doublers has the potential to correct the difficulties associated with current repair techniques and the ability to be applied where there are no rehabilitation options. It promises to be cost-effective with minimal disruption to the users of the structure. This report concludes a study into the application of composite patches on thick steel structures typically used in mining operations. Extreme fatigue, temperature, erosive, and corrosive environments induce an array of equipment damage. The current weld repair techniques for these structures provide a fatigue life that is inferior to that of the original plate. Subsequent cracking must be revisited on a regular basis. The use of composite doublers, which do not have brittle fracture problems such as those inherent in welds, can help extend the structure's fatigue life and reduce the equipment downtime. Two of the main issues for adapting aircraft composite repairs to civil applications are developing an installation technique for carbon steel and accommodating large repairs on extremely thick structures. This study developed and proved an optimum field installation process using specific mechanical and chemical surface preparation techniques coupled with unique, in-situ heating methods. In addition, a comprehensive performance assessment of composite doubler repairs was completed to establish the viability of this technology for large, steel structures. The factors influencing the durability of composite patches in severe field environments were evaluated along with related laminate design issues.

  3. Repairable chip bonding/interconnect process

    DOE Patents [OSTI]

    Bernhardt, Anthony F. (Berkeley, CA); Contolini, Robert J. (Livermore, CA); Malba, Vincent (Livermore, CA); Riddle, Robert A. (Tracy, CA)

    1997-01-01T23:59:59.000Z

    A repairable, chip-to-board interconnect process which addresses cost and testability issues in the multi-chip modules. This process can be carried out using a chip-on-sacrificial-substrate technique, involving laser processing. This process avoids the curing/solvent evolution problems encountered in prior approaches, as well is resolving prior plating problems and the requirements for fillets. For repairable high speed chip-to-board connection, transmission lines can be formed on the sides of the chip from chip bond pads, ending in a gull wing at the bottom of the chip for subsequent solder.

  4. Repairable chip bonding/interconnect process

    DOE Patents [OSTI]

    Bernhardt, A.F.; Contolini, R.J.; Malba, V.; Riddle, R.A.

    1997-08-05T23:59:59.000Z

    A repairable, chip-to-board interconnect process which addresses cost and testability issues in the multi-chip modules is disclosed. This process can be carried out using a chip-on-sacrificial-substrate technique, involving laser processing. This process avoids the curing/solvent evolution problems encountered in prior approaches, as well is resolving prior plating problems and the requirements for fillets. For repairable high speed chip-to-board connection, transmission lines can be formed on the sides of the chip from chip bond pads, ending in a gull wing at the bottom of the chip for subsequent solder. 10 figs.

  5. Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's Possible forPortsmouth/Paducah47,193.70 Hg Mercury 35 Br BromineProbing the Proton's Weak2 Problem

  6. Hp-spectral Methods for Structural Mechanics and Fluid Dynamics Problems

    E-Print Network [OSTI]

    Ranjan, Rakesh

    2011-08-08T23:59:59.000Z

    based finite element methods with the Penalty finite element method are presented for modelling porous media flow problems. Finally, we explore applications to some CFD problems namely, the flow past a cylinder and forward facing step....

  7. Rapid road repair vehicle

    DOE Patents [OSTI]

    Mara, Leo M. (Livermore, CA)

    1999-01-01T23:59:59.000Z

    Disclosed are improvments to a rapid road repair vehicle comprising an improved cleaning device arrangement, two dispensing arrays for filling defects more rapidly and efficiently, an array of pre-heaters to heat the road way surface in order to help the repair material better bond to the repaired surface, a means for detecting, measuring, and computing the number, location and volume of each of the detected surface imperfection, and a computer means schema for controlling the operation of the plurality of vehicle subsystems. The improved vehicle is, therefore, better able to perform its intended function of filling surface imperfections while moving over those surfaces at near normal traffic speeds.

  8. Incremental temporal reasoning in job shop scheduling repair

    E-Print Network [OSTI]

    Huang, Y.

    A working predictive schedule can be useless because of the various external or internal disruptions in a job shop. Total rescheduling may cause problems such as shop floor nervousness. Thus, the job shop scheduling repair ...

  9. Quantum mechanical aspects of friction and electric resistance in microscopic problems with applications to radiation physics

    E-Print Network [OSTI]

    Ulmer, W

    2015-01-01T23:59:59.000Z

    Friction incorporates the close connection between classical mechanics in irreversible thermodynamics. The translation to a quantum mechanical foundation is not trivial and requires a generalization of the Lagrange function. A change to electromagnetic circuits appears to more adequate, since the electric analogue (Ohms law) is related to scatter of electrons at lattice vibrations.

  10. The Mechanics of Materials in Contact Problems Georges Cailletaud1,a , Stphanie Basseville2,b , Julian Durand1,c ,

    E-Print Network [OSTI]

    Boyer, Edmond

    Georges.Cailletaud@mines-paristech.fr, bStephanie.Basseville@usvq.fr, cJulian.Durand@mines-paristech.fr, dfeyel@onera.fr, eThe Mechanics of Materials in Contact Problems Georges Cailletaud1,a , Stéphanie Basseville2,b , Julian Durand1,c , Frédéric Feyel3,d , Henry Proudhon1,e , Lingtao Sun1,f, Vladislav Yastrebov1,g 1MINES

  11. Window Replacement, Rehabilitation, & Repair Guides - Building...

    Energy Savers [EERE]

    Window Replacement, Rehabilitation, & Repair Guides - Building America Top Innovation Window Replacement, Rehabilitation, & Repair Guides - Building America Top Innovation Effec...

  12. Class of model problems in three-body quantum mechanics that admit exact solutions

    SciTech Connect (OSTI)

    Takibayev, N. Zh., E-mail: teta@nursat.kz [Abay Kazakh National Pedagogical University (Kazakhstan)

    2008-03-15T23:59:59.000Z

    An approach to solving scattering problems in three-body systems for cases where the mass of one of the particles is extremely small in relation to the masses of the other two particles and where the pair potentials of interaction between the particles involved are separable is developed. Exact analytic solutions to such model problems are found for the scattering of a light particle on two fixed centers and on two interacting heavy particles. It is shown that new resonances and a dynamical resonance enhancement may appear in a three-body system.

  13. Philosophy of mind and the problem of free will in the light of quantum mechanics

    E-Print Network [OSTI]

    Henry P. Stapp

    2008-05-01T23:59:59.000Z

    Defects occasioned by the advent of quantum mechanics are described in detail of recent arguments by John Searle and by Jaegwon Kim pertaining to the question of the complete reducibility to the physical of the apparent capacity of a person's conscious thoughts to affect the behaviour of that person's physically described brain.

  14. Philosophy of Mind and the Problem of FreeWill in the Light of Quantum Mechanics.

    SciTech Connect (OSTI)

    Stapp, Henry; Stapp, Henry P

    2008-04-01T23:59:59.000Z

    Arguments pertaining to the mind-brain connection and to the physical effectiveness of our conscious choices have been presented in two recent books, one by John Searle, the other by Jaegwon Kim. These arguments are examined, and it is argued that the difficulties encountered arise from a defective understanding and application of a pertinent part of contemporary science, namely quantum mechanics.

  15. Slowly changing potential problems in Quantum Mechanics: Adiabatic Theorems, Ergodic Theorems, and Scattering

    E-Print Network [OSTI]

    Shmuel Fishman; Avy Soffer

    2015-01-06T23:59:59.000Z

    We employ the recently developed multi-time scale averaging method to study the large time behavior of slowly changing (in time) Hamiltonians. We treat some known cases in a new way, such as the Zener problem, and we give another proof of the Adiabatic Theorem in the gapless case. We prove a new Uniform Ergodic Theorem for slowly changing unitary operators. This theorem is then used to derive the adiabatic theorem, do the scattering theory for such Hamiltonians, and prove some classical propagation estimates and Asymptotic Completeness.

  16. Regulation of DNA repair by parkin

    SciTech Connect (OSTI)

    Kao, Shyan-Yuan, E-mail: shyan-yuan_kao@meei.harvard.edu [Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114 (United States)] [Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114 (United States)

    2009-05-01T23:59:59.000Z

    Mutation of parkin is one of the most prevalent causes of autosomal recessive Parkinson's disease (PD). Parkin is an E3 ubiquitin ligase that acts on a variety of substrates, resulting in polyubiquitination and degradation by the proteasome or monoubiquitination and regulation of biological activity. However, the cellular functions of parkin that relate to its pathological involvement in PD are not well understood. Here we show that parkin is essential for optimal repair of DNA damage. Parkin-deficient cells exhibit reduced DNA excision repair that can be restored by transfection of wild-type parkin, but not by transfection of a pathological parkin mutant. Parkin also protects against DNA damage-induced cell death, an activity that is largely lost in the pathological mutant. Moreover, parkin interacts with the proliferating cell nuclear antigen (PCNA), a protein that coordinates DNA excision repair. These results suggest that parkin promotes DNA repair and protects against genotoxicity, and implicate DNA damage as a potential pathogenic mechanism in PD.

  17. Polymer nanocomposites for high-temperature composite repair

    SciTech Connect (OSTI)

    Sheng, Xia

    2008-12-01T23:59:59.000Z

    A novel repair agent for resin-injection repair of advanced high temperature composites was developed and characterized. The repair agent was based on bisphenol E cyanate ester (BECy) and reinforced with alumina nanoparticles. To ensure good dispersion and compatibility with the BECy matrix in nanocomposites, the alumina nanoparticles were functionalized with silanes. The BECy nanocomposites, containing bare and functionalized alumina nanoparticles, were prepared and evaluated for their thermal, mechanical, rheological, and viscoelastic properties. The monomer of BECy has an extremely low viscosity at ambient temperature, which is good for processability. The cured BECy polymer is a highly cross-linked network with excellent thermal mechanical properties, with a high glass transition temperature (T{sub g}) of 270 C and decomposition temperature above 350 C. The incorporation of alumina nanoparticles enhances the mechanical and rheological properties of the BECy nanocomposites. Additionally, the alumina nanoparticles are shown to catalyze the cure of BECy. Characterization of the nanocomposites included dynamic mechanical analysis, differential scanning calorimetry, thermogravimetric analysis, rheological and rheokinetic evaluation, and transmission electron microscopy. The experimental results show that the BECy nanocomposite is a good candidate as repair agent for resin-injection repair applications.

  18. Industrial motor repair in the United States

    SciTech Connect (OSTI)

    Schueler, V.; Leistner, P.; Douglass, J.

    1994-09-01T23:59:59.000Z

    This report characterizes the motor repair industry in the United States; summarizes current motor repair and testing practice; and identifies barriers to energy motor repair practice and recommends strategies for overcoming those barriers.

  19. Automatic Repair of Buggy If Conditions and Missing Preconditions with SMT

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Automatic Repair of Buggy If Conditions and Missing Preconditions with SMT Favio De into a Satisfiability Modulo Theory (SMT) problem, and translating the SMT result ­ if there exists one ­ into a source, Verification Keywords Automatic repair, test suite, buggy if condition, missing pre- condition, SMT, angelic

  20. Thermosetting Polymer-Matrix Composites for Strucutral Repair Applications

    SciTech Connect (OSTI)

    William Kirby Goertzen

    2007-12-01T23:59:59.000Z

    Several classes of thermosetting polymer matrix composites were evaluated for use in structural repair applications. Initial work involved the characterization and evaluation of woven carbon fiber/epoxy matrix composites for structural pipeline repair. Cyanate ester resins were evaluated as a replacement for epoxy in composites for high-temperature pipe repair applications, and as the basis for adhesives for resin infusion repair of high-temperature composite materials. Carbon fiber/cyanate ester matrix composites and fumed silica/cyanate ester nanocomposites were evaluated for their thermal, mechanical, viscoelastic, and rheological properties as they relate to their structure, chemistry, and processing characteristics. The bisphenol E cyanate ester under investigation possesses a high glass transition temperature, excellent mechanical properties, and unique ambient temperature processability. The incorporate of fumed silica served to enhance the mechanical and rheological properties of the polymer and reduce thermal expansion without sacrificing glass transition or drastically altering curing kinetics. Characterization of the composites included dynamic mechanical analysis, thermomechanical analysis, differential scanning calorimetry, thermogravimetric analysis, rheological and rheokinetic evaluation, and transmission electron microscopy.

  1. Mammalian DNA Repair. Final Report

    SciTech Connect (OSTI)

    None

    2003-01-24T23:59:59.000Z

    The Gordon Research Conference (GRC) on Mammalian DNA Repair was held at Harbortown Resort, Ventura Beach, CA. Emphasis was placed on current unpublished research and discussion of the future target areas in this field.

  2. Inspect and Repair Steam Traps

    SciTech Connect (OSTI)

    Not Available

    2006-01-01T23:59:59.000Z

    This revised ITP tip sheet on inspecting and repairing steam traps provide how-to advice for improving industrial steam systems using low-cost, proven practices and technologies.

  3. Emerging Trends in Heart Valve Engineering: Part III. Novel Technologies for Mitral Valve Repair and Replacement

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    and J. D. Puskas. Mitral-valve repair versus replacement forbioprosthetic heart valves. Ann. Thorac. Surg. 71:S417–mechanics of arti?cial heart valves. Clin. Exp. Pharmacol.

  4. Using instrument scraper surveys for corrosion repair

    SciTech Connect (OSTI)

    Akhnoukh, S.R.; Baghabrah, M.A. (Aramco (SA))

    1990-07-01T23:59:59.000Z

    This paper reports on a program for overall pipe line repair. This program was implemented to maintain pipe line integrity and for identifying problem areas which require reconditioning or replacing by: reviewing pipe line leak history; checking periodically lifetime expectancy and integrity of pipe coatings; using cathodic protection annual survey results to locate low potential areas (close-interval survey is needed to identify the exact location of corrosion); and hydrotesting the pipe line (using leaks or ruptures from the hydrotest to identify problem areas). The pipe line revalidation plan is insufficient for identifying pipe line leaks. Instrumented pig testing provides more accurate and reliable ways of testing the pipe line for internal or external corrosion or defects.

  5. Biomolecular Simulation of Base Excision Repair and Protein Signaling

    SciTech Connect (OSTI)

    Straatsma, TP; McCammon, J. A.; Miller, John H.; Smith, Paul E.; Vorpagel, Erich R.; Wong, Chung F.; Zacharias, Martin W.

    2006-03-03T23:59:59.000Z

    The goal of the Biomolecular Simulation of Base Excision Repair and Protein Signaling project is to enhance our understanding of the mechanism of human polymerase-?, one of the key enzymes in base excision repair (BER) and the cell-signaling enzymes cyclic-AMP-dependent protein kinase. This work used molecular modeling and simulation studies to specifically focus on the • dynamics of DNA and damaged DNA • dynamics and energetics of base flipping in DNA • mechanism and fidelity of nucleotide insertion by BER enzyme human polymerase-? • mechanism and inhibitor design for cyclic-AMP-dependent protein kinase. Molecular dynamics simulations and electronic structure calculations have been performed using the computer resources at the Molecular Science Computing Facility at the Environmental Molecular Sciences Laboratory.

  6. Injection repair of carbon fiber/bismaleimide composite panels with bisphenol E cyanate ester resin

    SciTech Connect (OSTI)

    Thunga, Mahendra [Ames Laboratory; Bauer, Amy [Iowa State University; Obusek, Kristine [Fleet Readiness Center East; Meilunas, Ray [Naval Air Warfare Center Aircraft Division; Akinc, Mufit [Ames Laboratory; Kessler, Michael R [Ames Laboratory

    2014-08-01T23:59:59.000Z

    Resin injection of bisphenol E cyanate ester, a low viscosity resin that cures into a high temperature thermoset polymer, is investigated as a reliable repair method to restore strength and stiffness in delaminated carbon fiber/bismaleimide composites used in aircraft panels. The influence of temperature on the viscosity of the uncured resin was measured to optimize the injection conditions for high resin infiltration into the delaminations. The repair efficiency of the resin was evaluated by varying the panel thickness and the method by which the delamination damage was created in the composite specimens. Ultrasonic scanning (C-scan), flash thermography images, and cross-section analysis of repaired panels revealed excellent resin infiltration into the damaged region. Evaluation of mechanical repair efficiency using both bending stiffness and in-plain compressive strength of the composite panels as the repair metrics showed values exceeding 100%.

  7. Verification of Motor Repair Quality

    E-Print Network [OSTI]

    Butler, K.

    Motor testing at Advanced Energy has shown that a motor that has not suffered irreparable damage as a result of failure can be repaired to perform as well as before the failure. But the only way to achieve the performance level of an energy...

  8. Fabrication Flaw Density and Distribution In Repairs to Reactor Pressure Vessel and Piping Welds

    SciTech Connect (OSTI)

    GJ Schuster, FA Simonen, SR Doctor

    2008-04-01T23:59:59.000Z

    The Pacific Northwest National Laboratory is developing a generalized fabrication flaw distribution for the population of nuclear reactor pressure vessels and for piping welds in U.S. operating reactors. The purpose of the generalized flaw distribution is to predict component-specific flaw densities. The estimates of fabrication flaws are intended for use in fracture mechanics structural integrity assessments. Structural integrity assessments, such as estimating the frequency of loss-of-coolant accidents, are performed by computer codes that require, as input, accurate estimates of flaw densities. Welds from four different reactor pressure vessels and a collection of archived pipes have been studied to develop empirical estimates of fabrication flaw densities. This report describes the fabrication flaw distribution and characterization in the repair weld metal of vessels and piping. This work indicates that large flaws occur in these repairs. These results show that repair flaws are complex in composition and sometimes include cracks on the ends of the repair cavities. Parametric analysis using an exponential fit is performed on the data. The relevance of construction records is established for describing fabrication processes and product forms. An analysis of these records shows there was a significant change in repair frequency over the years when these components were fabricated. A description of repair flaw morphology is provided with a discussion of fracture mechanics significance. Fabrication flaws in repairs are characterized using optimized-access, high-sensitivity nondestructive ultrasonic testing. Flaw characterizations are then validated by other nondestructive evaluation techniques and complemented by destructive testing.

  9. Endovascular Abdominal Aortic Aneurysm Repair in the Presence of a Kidney Transplant: Therapeutic Considerations

    SciTech Connect (OSTI)

    Karkos, Christos D., E-mail: ckarkos@hotmail.com; McMahon, Greg [Leicester Royal Infirmary, Department of Vascular and Endovascular Surgery (United Kingdom); Fishwick, Guy [Leicester Royal Infirmary, Department of Radiology (United Kingdom); Lambert, Kelly; Bagga, Ajay; McCarthy, Mark J. [Leicester Royal Infirmary, Department of Vascular and Endovascular Surgery (United Kingdom)

    2006-04-15T23:59:59.000Z

    Abdominal aortic aneurysm (AAA) repair in the presence of a kidney transplant can be extremely challenging, as it carries significant risks of renal ischemia. Endovascular repair is an attractive option, as it can be performed with little or no impairment of renal arterial flow. We describe the endovascular management of a recurrent AAA in a patient with a functioning renal transplant using a custom-made aorto-uni-iliac device. We discuss the planning and the potential problems of the technique.

  10. Impact of a body against a rigid wall. Problem involving non-smooth and history dependent energy dissipation mechanism

    E-Print Network [OSTI]

    Zorica, Dusan; Grahovac, Nenad

    2013-01-01T23:59:59.000Z

    We study the impact of a body against a rigid wall. The body consists of a rigid block and a viscoelastic rod described by the fractional Zener model. Translatory motion of a body is influenced by the dry friction, described by the set-valued Coulomb friction law. The problem is treated analytically by the use of the Laplace transform method and solutions are obtained in a convolution form. These solutions are compared with the ones obtained by using the numerical method.

  11. The role of vascular endothelial growth factor (VEGF) in repair and recovery from acute respiratory distress syndrome (ARDS) 

    E-Print Network [OSTI]

    Medford, Andrew R.L

    2007-01-01T23:59:59.000Z

    Acute Respiratory Distress Syndrome (ARDS) is the most extreme form of acute lung injury and continues to have a significant morbidity and mortality. Unfortunately, the mechanisms involved in the recovery and repair of ...

  12. GENETIC AND MOLECULAR ANALYSIS OF DNA DAMAGE REPAIR AND TOLERANCE PATHWAYS.

    SciTech Connect (OSTI)

    SUTHERLAND, B.M.

    2001-07-26T23:59:59.000Z

    Radiation can damage cellular components, including DNA. Organisms have developed a panoply of means of dealing with DNA damage. Some repair paths have rather narrow substrate specificity (e.g. photolyases), which act on specific pyrimidine photoproducts in a specific type (e.g., DNA) and conformation (double-stranded B conformation) of nucleic acid. Others, for example, nucleotide excision repair, deal with larger classes of damages, in this case bulky adducts in DNA. A detailed discussion of DNA repair mechanisms is beyond the scope of this article, but one can be found in the excellent book of Friedberg et al. [1] for further detail. However, some DNA damages and paths for repair of those damages important for photobiology will be outlined below as a basis for the specific examples of genetic and molecular analysis that will be presented below.

  13. The Gordon conference on mammalian DNA repair

    SciTech Connect (OSTI)

    Cleaver, J.E.; Smerdon, M.J.

    1993-12-31T23:59:59.000Z

    A brief overview of the Gordon Conference on Mammalian Repair held February 1-5, 1993 in Ventura, California is presented.

  14. Assessment of HYGAS mechanical equipment

    SciTech Connect (OSTI)

    Albrecht, P.R.; Kramberger, F.E.; Recupero, R.M.; Verden, M.L.; Rees, K.

    1980-10-01T23:59:59.000Z

    The HYGAS process, which converts coal to substitute natural gas, is being developed by the Institute of Gas Technology (IGT) using an 80 ton per day pilot plant located in Chicago, Illinois. Plant design started in 1967 and testing began in October 1971. Since then, 18,000 tons of both Eastern and Western coal have been gasified. Assessment of the mechanical equipment was made by Mechanical Technology Incorporated (MTI) in collaboration with a DOE on-site representative and a representative from IGT, the operating contractor. Data for the assessment were obtained by reviewing all available maintenance records, by interviewing key personnel from maintenance and operations, and by observing repairs and maintenance procedures where possible. While operating the plant, a variety of equipment problems were addressed, many of which are generic to HYGAS as well as other coal conversion processes. Some problems were solved completely while others were solved to suit the limited needs of the pilot plant. Accordingly, the emphasis of this study is on the degree of success in dealing with equipment failures, the unresolved problems and the implication to future coal conversion plants.

  15. Role of DNA repair protein ERCC1 in skin cancer 

    E-Print Network [OSTI]

    Song, Liang

    2009-01-01T23:59:59.000Z

    Nucleotide excision repair (NER) is one of the major repair systems for removal of DNA lesions. The NER pathway has evolved mainly to repair UV-induced DNA damage and is also active against a broad range of endogenously ...

  16. The feasibility of electrophoretic repair of impoundment leaks

    E-Print Network [OSTI]

    Han, Ji-Seok

    2002-01-01T23:59:59.000Z

    finding, repairing and testing the leaks, are tedious, expensive, and dangerous to workers. Electrophoretic repair technique is an innovative, economic, and safe method to repair the leakage of impoundments. A suspension of clay particles is induced...

  17. Automotive Repair by Number Theory Bart Snapp and Chris Snapp

    E-Print Network [OSTI]

    Snapp, Bart

    Automotive Repair by Number Theory Bart Snapp and Chris Snapp While repairing the ignition switch on a 1981 Fiat Spider, we discovered the following connection between number theory and automotive repair

  18. Internal pipe attachment mechanism

    DOE Patents [OSTI]

    Bast, R.M.; Chesnut, D.A.; Henning, C.D.; Lennon, J.P.; Pastrnak, J.W.; Smith, J.A.

    1994-12-13T23:59:59.000Z

    An attachment mechanism is described for repairing or extending fluid carrying pipes, casings, conduits, etc. utilizing one-way motion of spring tempered fingers to provide a mechanical connection between the attachment mechanism and the pipe. The spring tempered fingers flex to permit insertion into a pipe to a desired insertion depth. The mechanical connection is accomplished by reversing the insertion motion and the mechanical leverage in the fingers forces them outwardly against the inner wall of the pipe. A seal is generated by crushing a sealing assembly by the action of setting the mechanical connection. 6 figures.

  19. Electric plugs--repair or replace The problem

    E-Print Network [OSTI]

    need s New plug­if your old one cannot be used. (Buy one with a UL label) s A screwdriver s A knife How to 1. Cut the cord off at the damaged part (Fig. 1). 2. Slip the plug back on the cord (Fig. 2). 3

  20. INTERNAL REPAIR OF PIPELINES REVIEW & EVALUATION OF INTERNAL PIPELINE REPAIR TRIALS REPORT

    SciTech Connect (OSTI)

    Robin Gordon; Bill Bruce; Ian Harris; Dennis Harwig; George Ritter; Bill Mohr; Matt Boring; Nancy Porter; Mike Sullivan; Chris Neary

    2004-09-01T23:59:59.000Z

    The two broad categories of fiber-reinforced composite liner repair and deposited weld metal repair technologies were reviewed and evaluated for potential application for internal repair of gas transmission pipelines. Both are used to some extent for other applications and could be further developed for internal, local, structural repair of gas transmission pipelines. Evaluation trials were conducted on pipe sections with simulated corrosion damage repaired with glass fiber-reinforced composite liners, carbon fiber-reinforced composite liners, and weld deposition. Additional un-repaired pipe sections were evaluated in the virgin condition and with simulated damage. Hydrostatic failure pressures for pipe sections repaired with glass fiber-reinforced composite liner were only marginally greater than that of pipe sections without liners, indicating that this type of liner is generally ineffective at restoring the pressure containing capabilities of pipelines. Failure pressure for pipe repaired with carbon fiber-reinforced composite liner was greater than that of the un-repaired pipe section with damage, indicating that this type of liner is effective at restoring the pressure containing capability of pipe. Pipe repaired with weld deposition failed at pressures lower than that of un-repaired pipe in both the virgin and damaged conditions, indicating that this repair technology is less effective at restoring the pressure containing capability of pipe than a carbon fiber-reinforced liner repair. Physical testing indicates that carbon fiber-reinforced liner repair is the most promising technology evaluated to-date. Development of a comprehensive test plan for this process is recommended for use in the next phase of this project.

  1. Fast Interactive Simulations of Mitral Valve Repair Neil A. Tenenholtz, Peter E. Hammer, Robert D. Howe

    E-Print Network [OSTI]

    Fast Interactive Simulations of Mitral Valve Repair Neil A. Tenenholtz, Peter E. Hammer, Robert D. Howe Keywords: Surgical simulation, human-computer interaction, haptics, mitral valve, cardiac surgery. I. Problem Solved A healthy mitral valve ensures the one-way flow of oxygenated blood from the left

  2. Developments advance subsea pipelaying, inspection, repair

    SciTech Connect (OSTI)

    NONE

    1997-09-15T23:59:59.000Z

    Recent advances in laying, inspecting, and repairing pipelines are helping to cut both costs and time. A new dredging system that employs jets to clear a subsea trench for pipelay received trials off Belgium last spring. Also, within the last year, projects in the Middle East and North Sea employed technologies that promise to make inspecting the surface of a subsea pipeline in difficult terrain easier, less time consuming, and therefore less costly. Plus, subsea repair of damaged pipelines may take less time with a new ``stabbable`` pipe connector. The paper describes jet dredging, inspection advance, support software, the North Sea site, and pipeline repair.

  3. The Stumbling Block in Lung Repair of Emphysema: Elastic Fiber Assembly

    E-Print Network [OSTI]

    Mecham, Robert

    The Stumbling Block in Lung Repair of Emphysema: Elastic Fiber Assembly Adrian Shifren and Robert P properties of the lung are largely determined by the connective tissue networks laid down during development. The macromolecules most important for lung mechanics and structural integrity are collagen, elastin

  4. CATASTROPHIC REPAIR REQUEST CHECKLIST Office of Research

    E-Print Network [OSTI]

    Schladow, S. Geoffrey

    Not Meet Policy Not Sure Equipment may not be covered by a service contract that provides for repair Contacted: ______________ Amount of Annual Service Contract: $ ___________ Meets Policy Info Pending Does

  5. Reducing Your Leak Rate Without Repairing Leaks 

    E-Print Network [OSTI]

    Beals, C.

    2005-01-01T23:59:59.000Z

    As plant personnel know, repairing compressed air leaks can be an expensive, labor intensive and never-ending process. This article discusses ways plant personnel can reduce and maintain their leak rate at a lower level ...

  6. Vehicle Repair Policy Outline the policy regarding vehicle repair on University of Michigan (U-M) vehicles.

    E-Print Network [OSTI]

    Kirschner, Denise

    Vehicle Repair Policy Objective Outline the policy regarding vehicle repair on University of Michigan (U-M) vehicles. Policy 1. All vehicle repairs performed on U-M vehicles must be coordinated facility to repair their fleet vehicles. 2. U-M vehicles leased through Fleet Services include routine

  7. Quantum correlation between the selection of the problem and that of the solution sheds light on the mechanism of the quantum speed-up

    SciTech Connect (OSTI)

    Castagnoli, Giuseppe [Via San Bernardo 9/A, I-16030 Pieve Ligure (Genova) (Italy)

    2010-11-15T23:59:59.000Z

    In classical problem solving, there is, of course, correlation between the selection of the problem on the part of Bob (the problem setter) and that of the solution on the part of Alice (the problem solver). In quantum problem solving, this correlation becomes quantum. This means that Alice contributes to selecting 50% of the information that specifies the problem. As the solution is a function of the problem, this gives to Alice advanced knowledge of 50% of the information that specifies the solution. Both the quadratic and exponential speed-ups are explained by the fact that quantum algorithms start from this advanced knowledge.

  8. Energy and Technology Review: Unlocking the mysteries of DNA repair

    SciTech Connect (OSTI)

    Quirk, W.A.

    1993-04-01T23:59:59.000Z

    DNA, the genetic blueprint, has the remarkable property of encoding its own repair following diverse types of structural damage induced by external agents or normal metabolism. We are studying the interplay of DNA damaging agents, repair genes, and their protein products to decipher the complex biochemical pathways that mediate such repair. Our research focuses on repair processes that correct DNA damage produced by chemical mutagens and radiation, both ionizing and ultraviolet. The most important type of DNA repair in human cells is called excision repair. This multistep process removes damaged or inappropriate pieces of DNA -- often as a string of 29 nucleotides containing the damage -- and replaces them with intact ones. We have isolated, cloned, and mapped several human repair genes associated with the nucleotide excision repair pathway and involved in the repair of DNA damage after exposure to ultraviolet light or mutagens in cooked food. We have shown that a defect in one of these repair genes, ERCC2, is responsible for the repair deficiency in one of the groups of patients with the recessive genetic disorder xeroderma pigmentosum (XP group D). We are exploring ways to purify sufficient quantities (milligrams) of the protein products of these and other repair genes so that we can understand their functions. Our long-term goals are to link defective repair proteins to human DNA repair disorders that predispose to cancer, and to produce DNA-repair-deficient mice that can serve as models for the human disorders.

  9. INTERNAL REPAIR OF GAS PIPLINES SURVEY OF OPERATOR EXPERIENCE AND INDUSTRY NEEDS REPORT

    SciTech Connect (OSTI)

    Ian D. Harris

    2003-09-01T23:59:59.000Z

    A repair method that can be applied from the inside of a gas transmission pipeline (i.e., a trenchless repair) is an attractive alternative to conventional repair methods since the need to excavate the pipeline is precluded. This is particularly true for pipelines in environmentally sensitive and highly populated areas. The objectives of the project are to evaluate, develop, demonstrate, and validate internal repair methods for pipelines; develop a functional specification for an internal pipeline repair system; and prepare a recommended practice for internal repair of pipelines. The purpose of this survey is to better understand the needs and performance requirements of the natural gas transmission industry regarding internal repair. A total of fifty-six surveys were sent to pipeline operators. A total of twenty completed surveys were returned, representing a 36% response rate, which is considered very good given the fact that tailored surveys are known in the marketing industry to seldom attract more than a 10% response rate. The twenty survey responses produced the following principal conclusions: (1) Use of internal weld repair is most attractive for river crossings, under other bodies of water (e.g., lakes and swamps) in difficult soil conditions, under highways, under congested intersections, and under railway crossings. All these areas tend to be very difficult and very costly if, and where, conventional excavated repairs may be currently used. (2) Internal pipe repair offers a strong potential advantage to the high cost of horizontal direct drilling (HDD) when a new bore must be created to solve a leak or other problem in a water/river crossing. (3) The typical travel distances required can be divided into three distinct groups: up to 305 m (1,000 ft.); between 305 m and 610 m (1,000 ft. and 2,000 ft.); and beyond 914 m (3,000 ft.). In concept, these groups require pig-based systems; despooled umbilical systems could be considered for the first two groups. For the last group a self-propelled system with an onboard self-contained power and welding system is required. (4) Pipe size range requirements range from 50.8 mm (2 in.) through 1,219.2 mm (48 in.) in diameter. The most common size range for 80% to 90% of operators surveyed is 508 mm to 762 mm (20 in. to 30 in.) diameter, with 95% using 558.8 mm (22 in.) diameter pipe.

  10. Hurricane-damaged Gulf of Mexico pipeline repaired with cold forging

    SciTech Connect (OSTI)

    Lewis, G. (Texaco Pipeline Inc., Houma, LA (United States)); DeGruy, P. (Texaco Inc., New Orleans, LA (United States)); Avery, L. (Big Inch Marine Systems Inc., Lafayette, LA (United States))

    1993-05-03T23:59:59.000Z

    Damage to Texaco Pipeline Inc.'s Eugene Island Pipeline System (EIPS) in last year's Hurricane Andrew prompted a complex repair project unique for the Gulf of Mexico. Damage, suffered when the anchor of a runaway semisubmersible drilling rig crashed into the 20-in. EPIS during the height of the storm, caused the pipeline to fail under pressure within 48 hr. after start-up following the storm. The paper describes the importance of the EIPS; system safety; Andrew's damage; locating the leak; repair options; the chosen system; mechanical bonding; end connectors and ball flanges; and diving operations.

  11. HANFORD SITE LOW EXPOSURE PIPELINE REPAIR USING A NON-METALLIC COMPOSITE SYSTEM

    SciTech Connect (OSTI)

    HUTH RJ

    2009-11-12T23:59:59.000Z

    At the Department of Energy, Richland Operations (DOE-RL) Hanford site in eastern Washington, a 350 mm (14 inch) diameter high density polyethylene (HDPE) pump recirculation pipeline failed at a bonded joint adjacent to a radiologically and chemically contaminated groundwater storage basin. The responsible DOE-RL contractor, CH2MHill Plateau Remediation Company, applied a fiberglass reinforced plastic (composite) field repair system to the failed joint. The system was devised specifically for the HDPE pipe repair at the Hanford site, and had not been used on this type of plastic piping previously. This paper introduces the pipe failure scenario, describes the options considered for repair and discusses the ultimate resolution of the problem. The failed pipeline was successfully returned to service with minimal impact on waste water treatment plant operating capacity. Additionally, radiological and chemical exposures to facility personnel were maintained as low as reasonably achievable (ALARA). The repair is considered a success for the near term, and future monitoring will prove whether the repair can be considered for long term service and as a viable alternative for similar piping failures at the Hanford site.

  12. H A&S 222d/253e: Introduction to Energy and Environment (Life Under the Pale Sun) Problem Set 1: Out: Weds. 11 April 2006 Mechanical and thermal energy

    E-Print Network [OSTI]

    H A&S 222d/253e: Introduction to Energy and Environment (Life Under the Pale Sun) Spring 07 Problem Set 1: Out: Weds. 11 April 2006 Mechanical and thermal energy Back: Weds. 18 April 1. The total `marketable'energy use in the world is estimated as 4 x 1020 Joules/year. In class we converted this to watts

  13. Mechanisms of initiation of DNA mismatch repair in Saccharomyces cerevisiae

    E-Print Network [OSTI]

    Shell, Scarlet Sara

    2008-01-01T23:59:59.000Z

    or the cisplatin-d(GpG) adduct. Proc Natl Acad Sci U S A 93,or the cisplatin-d(GpG) adduct. Proc Natl Acad Sci U S A 93,or the cisplatin-d(GpG) adduct. Proc Natl Acad Sci U S A 93,

  14. A sociotechnical framework for understanding infrastructure breakdown and repair

    SciTech Connect (OSTI)

    Sims, Benjamin H [Los Alamos National Laboratory

    2009-01-01T23:59:59.000Z

    This paper looks at how and why infrastructure is repaired. With a new era of infrastructure spending underway, policymakers need to understand and anticipate the particular technical and political challenges posed by infrastructure repair. In particular, as infrastructure problems are increasingly in the public eye with current economic stimulus efforts, the question has increasingly been asked: why has it been so difficult for the United Statesto devote sustained resources to maintaining and upgrading its national infrastructure? This paper provides a sociotechnical framework for understanding the challenges of infrastructure repair, and demonstrates this framework using a case study of seismic retrofit of freeway bridges in California. The design of infrastructure is quite different from other types of design work even when new infrastructure is being designed. Infrastructure projects are almost always situated within, and must work with, existing infrastructure networks. As a result, compared to design of more discrete technological artifacts, the design of infrastructure systems requires a great deal of attention to interfaces as well as adaptation of design to the constraints imposed by existing systems. Also, because of their scale, infrastructural technologies engage with social life at a level where explicit political agendas may playa central role in the design process. The design and building of infrastructure is therefore often an enormously complex feat of sociotechnical engineering, in which technical and political agendas are negotiated together until an outcome is reached that allows the project to move forward. These sociotechnical settlements often result in a complex balancing of powerful interests around infrastructural artifacts; at the same time, less powerful interests have historically often been excluded or marginalized from such settlements.

  15. HYDROGEN EFFECTS ON LASER ENGINEERED NET SHAPE (LENS) REPAIRED WELDMENTS

    SciTech Connect (OSTI)

    Korinko, P; Thad Adams, T

    2006-10-06T23:59:59.000Z

    New methods of repairing mis-machined components are always of interest. In this study, an innovative method using Laser Engineered Net Shape{trademark} (LENS{reg_sign}) forming was used to repair intentionally mis-machined test articles. The components were repaired and subsequently hydrogen charged and burst tested. The LENS repair did not have an adverse effect on the solid state weld process that was used to repair the components. Hydrogen charged samples failed in a similar manner to the uncharged samples. Overall, the prospects for LENS repairing similar products are favorable and further work is encouraged.

  16. Repair welding of fusion reactor components. Final technical report

    SciTech Connect (OSTI)

    Chin, B.A.; Wang, C.A.

    1997-09-30T23:59:59.000Z

    The exposure of metallic materials, such as structural components of the first wall and blanket of a fusion reactor, to neutron irradiation will induce changes in both the material composition and microstructure. Along with these changes can come a corresponding deterioration in mechanical properties resulting in premature failure. It is, therefore, essential to expect that the repair and replacement of the degraded components will be necessary. Such repairs may require the joining of irradiated materials through the use of fusion welding processes. The present ITER (International Thermonuclear Experimental Reactor) conceptual design is anticipated to have about 5 km of longitudinal welds and ten thousand pipe butt welds in the blanket structure. A recent study by Buende et al. predict that a failure is most likely to occur in a weld. The study is based on data from other large structures, particularly nuclear reactors. The data used also appear to be consistent with the operating experience of the Fast Flux Test Facility (FFTF). This reactor has a fuel pin area comparable with the area of the ITER first wall and has experienced one unanticipated fuel pin failure after two years of operation. The repair of irradiated structures using fusion welding will be difficult due to the entrapped helium. Due to its extremely low solubility in metals, helium will diffuse and agglomerate to form helium bubbles after being trapped at point defects, dislocations, and grain boundaries. Welding of neutron-irradiated type 304 stainless steels has been reported with varying degree of heat-affected zone cracking (HAZ). The objectives of this study were to determine the threshold helium concentrations required to cause HAZ cracking and to investigate techniques that might be used to eliminate the HAZ cracking in welding of helium-containing materials.

  17. SNL Researchers Assess Wind Turbine Blade Inspection and Repair...

    Office of Environmental Management (EM)

    Researchers Assess Wind Turbine Blade Inspection and Repair Methods SNL Researchers Assess Wind Turbine Blade Inspection and Repair Methods May 18, 2015 - 5:32pm Addthis A picture...

  18. Phonemic Categorization and Phonotactic Repair as Parallel Sublexical Processes 

    E-Print Network [OSTI]

    Ishikawa, Kiyoshi

    2014-07-01T23:59:59.000Z

    categorization and phonotactic repair are sublexical and simultaneous; phonotactic repairs themselves depend on coarticulation cues. Such models can be implemented in two different versions: suprasegmental matching, according to which a speech signal is matched...

  19. Development of a composite repair system for reinforcing offshore risers

    E-Print Network [OSTI]

    Alexander, Christopher Richard

    2009-05-15T23:59:59.000Z

    A research program was conducted to investigate the application of composite materials in repairing corroded offshore risers, leading to the development of an optimized repair using a hybrid carbon/E-glass system. The objective of this research...

  20. Repairing Type Errors in Functional Programs 

    E-Print Network [OSTI]

    McAdam, Bruce J

    Type systems for programming languages can be used by compilers to reject programs which are found to be unsound and which may, therefore, fail to execute successfully. When a program is rejected the programmer must repair it so that it can be type...

  1. An emergency response team for membrane repair

    E-Print Network [OSTI]

    Kirchhausen, Tomas

    events, which we focus on here. As discussed later, Ca2+ influx at the site of plasma membrane-fusion events are required to repair a torn plasma membrane, and we propose that this emergency products and the plasma membrane. Reseal or die. Plasma-membrane disruption is a normal event in the life

  2. EPA Lead Safety for Renovation, Repair and

    E-Print Network [OSTI]

    Tennessee, University of

    EPA Lead Safety for Renovation, Repair and Painting (RRP) Course Certified Renovators Class, CSP, CHMM, Certified Lead Paint Inspector.; Certified Renovator; EPA Ac- credited Lead RRP trainer or fax registratio Registration Form Cash Method of Payment Check Name Mailing Address Phone Lead Safety

  3. Visualization of Mismatch Repair in Bacterial Cells

    E-Print Network [OSTI]

    Smith, Bradley T.

    We determined the localizations of mismatch repair proteins in living Bacillus subtilis cells. MutS-GFP colocalized with the chromosome in all cells and formed foci in a subset of cells. MutL-GFP formed foci in a subset ...

  4. Antibody specific for a DNA repair protein

    DOE Patents [OSTI]

    Petrini, John H.; Morgan, William Francis; Maser, Richard Scott; Carney, James Patrick

    2006-07-11T23:59:59.000Z

    An isolated and purified DNA molecule encoding a DNA repair protein, p95, is provided, as is isolated and purified p95. Also provided are methods of detecting p95 and DNA encoding p95. The invention further provides p95 knock-out mice.

  5. DNA encoding a DNA repair protein

    DOE Patents [OSTI]

    Petrini, John H.; Morgan, William Francis; Maser, Richard Scott; Carney, James Patrick

    2006-08-15T23:59:59.000Z

    An isolated and purified DNA molecule encoding a DNA repair protein, p95, is provided, as is isolated and purified p95. Also provided are methods of detecting p95 and DNA encoding p95. The invention further provides p95 knock-out mice.

  6. Method for mask repair using defect compensation

    DOE Patents [OSTI]

    Sweeney, Donald W. (San Ramon, CA); Ray-Chaudhuri, Avijit K. (Livermore, CA)

    2001-01-01T23:59:59.000Z

    A method for repair of amplitude and/or phase defects in lithographic masks. The method involves modifying or altering a portion of the absorber pattern on the surface of the mask blank proximate to the mask defect to compensate for the local disturbance (amplitude or phase) of the optical field due to the defect.

  7. Laboratory testing of closure cap repair techniques

    SciTech Connect (OSTI)

    Persoff, P.; Moridis, G. [Lawrence Berkeley National Lab., CA (United States); Tuck, D.M. [Westinghouse Savannah River Company, Aiken, SC (United States)] [and others

    1996-10-01T23:59:59.000Z

    Landfill design requires a low permeability closure cap as well as a low permeability liner. The Savannah River Site, in South Carolina, has approximately 85 acres of mixed waste landfills covered with compacted kaolin clay. Maintaining low permeability of the clay cap requires both that the permeability of the compacted clay itself remain low and that the integrity of the barrier be maintained. Barrier breaches typically result from penetration by roots or animals, and especially cracks caused by uneven settling or desiccation. In this study, clay layers, 0.81 m in diameter and 7.6 cm thick, were compacted in 7 lysimeters to simulate closure caps. The hydraulic conductivity of each layer was measured, and the compacted clay layers (CCL`s) were cracked by drying. Then various repair techniques were applied and the effectiveness of each repair was assessed by remeasuring the hydraulic conductivity. Finally the repaired CCL was again dried and measured to determine how the repair responded to the conditions that caused the original failure. For a full report of this investigation see Persoff et al. Six repair techniques have been tested, four of which involve the use of injectable barrier liquids colloidal silica (CS) and polysiloxane (PSX) described below: (I) covering the crack with a bentonite geosynthetic clay liner (GCL), (ii) recompaction of new kaolinite at STD+3 moisture content joined to existing kaolinite that had dried and shrunk, (iii) direct injection of colloidal silica to a crack, (iv) injection of colloidal silica (CS) to wells in an overlying sand layer, (v) direct injection of polysiloxane to a crack, and (vi), injection of polysiloxane (PSX) to wells in an overlying soil layer.

  8. Original Full Length Article Inkjet-based biopatterning of SDF-1 augments BMP-2-induced repair of

    E-Print Network [OSTI]

    Weiss, Lee E.

    Original Full Length Article Inkjet-based biopatterning of SDF-1 augments BMP-2-induced repair Biopatterning BMP-2 SDF-1 TGF-1 Background: A major problem in craniofacial surgery is non-healing bone defects-derived factor-1 (SDF-1), transforming growth factor-1 (TGF-1), or co-therapies thereof. We tested the hypothesis

  9. New Technologies for Repairing Aging Cables in Nuclear Power Plants

    SciTech Connect (OSTI)

    Simmons, Kevin L.; Fifield, Leonard S.; Westman, Matthew P.

    2013-09-11T23:59:59.000Z

    The goal of this project is to demonstrate a proof-of-concept for a technique to repair aging cables that have been subjected to degradation associated with long-term thermal and radiation exposure in nuclear power plants. The physical degradation of the aging cables manifests itself primarily as cracking and increased brittleness of the polymeric electrical insulation. Therefore, the proposed cable-repair concept comprises development of techniques to impart a softening agent within the deteriorated polymer insulation jacket so as to regain the ability of the insulation to stretch without failing and possibly to heal existing cracks in the insulation. Our approach is to use commercially available ethylene-propylene rubber (EPR) as the relevant test material, demonstrate the adsorption of chemical treatments in the EPR and quantify changes in resulting physical and mechanical properties. EPR cable samples have been thermally treated in air to produce specimens corresponding to the full range of cable age-performance points from new (>350% elongation at break) to end-of-life (<50% elongation at break). The current focus is on two chemical treatments selected as candidates for restoring age-related cable elasticity loss: a rubber plasticizer and a reactive silane molecule. EPR specimens of 200, 150, 100, and 50% elongation at break have been soaked in the candidate chemical treatments and the kinetics of chemical uptake, measured by change in mass of the samples, has been determined. Mechanical properties as a function of aging and chemical treatment have been measured including ultimate tensile strength, tensile modulus at 50% strain, elongation at break, and storage modulus. Dimensional changes with treatment and changes in glass transition temperature were also investigated. These ongoing experiments are expected to provide insight into the physical-chemical nature of the effect of thermal degradation on EPR rejuvenation limits and to advance novel methods for restoring the ability of degraded EPR to be compliant and resist fracture. The results of this research reveal that absorption of chemical treatments can lower the glass transition temperature and modulus of EPR. Chemical treatments pursued thus far have proven ineffective at restoring EPR strength and elongation at break. Future work will combine the plasticizer modalities found to successfully increase the volume of the EPR, reduce EPR glass transition temperature and reduce EPR modulus with promising chemistries that will repair the damage of the polymer, potentially using the plasticizer as a host for the new chemistry.

  10. Efficacy of Low Level Laser Therapy After Hand Flexor Tendon Repair

    SciTech Connect (OSTI)

    Ayad, K. E.; Abd El Mejeed, S. F. [Faculty of Physical Therapy, Cairo University (Egypt); El Gohary, H. M.; Abd Elrahman, M.; Bekheet, A. B. [Al Sahel Teaching Hospital, Cairo (Egypt)

    2009-09-27T23:59:59.000Z

    Flexor tendon injury is a common problem requiring suturing repair followed by early postoperative mobilization. Muscle atrophy, joint stiffness, osteoarthritis, infection, skin necrosis, ulceration of joint cartilage and tendocutaneous adhesion are familiar complications produced by prolonged immobilization of surgically repaired tendon ruptures. The purpose of this study was to clarify the importance of low level laser therapy after hand flexor tendon repair in zone II. Thirty patients aging between 20 and 40 years were divided into two groups. Patients in group A (n = 15) received a conventional therapeutic exercise program while patients in group B (n = 15) received low level laser therapy combined with the same therapeutic exercise program. The results showed a statistically significant increase in total active motion of the proximal and distal interphalangeal joints as well as maximum hand grip strength at three weeks and three months postoperative, but improvement was more significant in group B. It was concluded that the combination of low level laser therapy and early therapeutic exercises was more effective than therapeutic exercises alone in improving total active motion of proximal and distal interphalangeal joints and hand grip strength after hand flexor tendon repair.

  11. Helium bubble distributions in reactor tank repair specimens

    SciTech Connect (OSTI)

    Tosten, M.H.; Kestin, P.A.

    1992-03-01T23:59:59.000Z

    This report discusses the Reactor Tank Repair (RTR) program was initiated to develop an in-tank repair process capable of repairing stress corrosion cracks within the SRS reactor tank walls, in the event that such a repair is needed. Previous attempts to repair C-reactor tank with a gas tungsten arc (GTA) welding process were unsuccessful due to significant cracking that occurred in the heat-affected-zones adjacent to the repair welds. It was determined that this additional cracking was a result of helium embrittlement caused by the combined effects of helium (existing within the tank walls), the high heat input associated with the GTA process, and weld shrinkage stresses. Based on the results of earlier studies it was suggested that the effects of helium embrittlement could be minimized by using a low heat input GMA process. Metallographic analysis played an important role throughout the investigation of alternative welding methods for the repair of helium-containing materials.

  12. H A&S 222a: Introduction to Energy and Environment (Life Under the Pale Sun) Problem Set 1b: 20 April 2006 More Mechanical Energy problems (if you did not

    E-Print Network [OSTI]

    speed. 6. Hybrid cars use both gasoline engines and electric motors. The gasoline powered engine is used're curious look up the stats on a Smart Car and compare). 4. ·If your SUV climbs a mountain road with slope 1 to charge the batteries and run the electric motor (using an alternator which converts mechanical energy

  13. Surgical technique, using skin, for repair of simultaneously ruptured anterior cruciate and medial collateral ligaments of the canine femorotibial articulation

    E-Print Network [OSTI]

    Chastain, Jamie Neal

    1959-01-01T23:59:59.000Z

    Agricultural and Mechanical College of Texan In Partial Fulfillnent of the !Iequireaents for the Degree Meeter of Science in Veterinary Medicine and Surgery by Janie Neal Chaetain January 1&359 SURGICAL TECHNI((UE ~ USIN'G SKIN ~ FOR REPAIR...

  14. Reprogramming the Mechanism of Action of Chlorambucil by Coupling to a GQuadruplex Ligand

    E-Print Network [OSTI]

    Di Antonio, Marco; McLuckie, Keith I. E.; Balasubramanian, Shankar

    2014-04-03T23:59:59.000Z

    Reprogramming the Mechanism of Action of Chlorambucil by Coupling to a G-quadruplex Ligand Marco Di Antonio,‡,† Keith I. E. McLuckie† and Shankar Balasubramanian ‡,†,§ ‡Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge... excision repair (NER) enzymes to overcome intra-strand crosslinks and repair T-T di- mers. 15 NER recognizes the damaged DNA strand, ex- cises it and replaces it with freshly synthesized DNA. 15 Because of its importance to DNA repair after UV expo...

  15. DNA repair is the target of novel antibiotics

    E-Print Network [OSTI]

    Gunderson, Carl Wayne

    2007-01-01T23:59:59.000Z

    W. & A. M. Segall, (2006) DNA repair, a novel antibacterialjunction-trapping peptides induce DNA damage and chromosomePeptide inhibitors of DNA cleavage by tyrosine recombinases

  16. Motor Repair Tech Brief | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdfBreaking ofOil &315_ArnibanPriorityof EnergyDepartmentRepair Tech Brief Motor

  17. Remarks on an attempted axiomatisation of Quantum Mechanics, due to Lucien Hardy, and Ten Theses on Hilbert's Sixth Problem and Quantum Measurement

    E-Print Network [OSTI]

    Joseph F. Johnson

    2006-06-15T23:59:59.000Z

    From the standpoint of Hilbert's Sixth Problem, which is the axiomatisation of Physics, the famous paper of Lucien Hardy's, Quantum Theory from Five Reasonable Axioms, is not relevant. The present paper argues that Hardy does not give a physical definition of `limit', and if we assume the usual mathematical definition of limit of a sequence, he fails to define a sequence in physical terms to which the usual definition is applicable. We argue that one should not, in fact, try to define probability in terms of the usual notion of limit of a sequence of results of a measurement because of seemingly insurmountable difficulties in axiomatising the notion of function or sequence in this context. Von Plato's and the authour's work (see http:arxiv.org/abs/quant-ph/0502124 and euclid.unh.edu/~jjohnson/axiomatics.html for larger context and further references) on the definition of physical probability needs to be used in this context. We conclude with ten theses on quantum measurement, from the standpoint of the Hilbert problem.

  18. Physical process Mechanical mechanisms

    E-Print Network [OSTI]

    Berlin,Technische Universität

    1 Physical process Generation · Mechanical mechanisms F = m·a · Electric/Magnetic mechanisms F = B·i·l · Fluid dynamic/Hydraulic mechanisms q, p, ij · Thermal/Optical #12;2 Source unit

  19. Coherent testing and simulation of composite blade repair

    E-Print Network [OSTI]

    McNichols, Brian Glenn

    1997-01-01T23:59:59.000Z

    The objective of this research program is to experimentally and computationally determine the static and fatigue response for two methods of repair to an E/Glass-Epoxy sandwich laminate. The proposed methods of repair are a scarf and overlap patch...

  20. Computational model of aortic valve surgical repair using grafted pericardium

    E-Print Network [OSTI]

    1 Computational model of aortic valve surgical repair using grafted pericardium Peter E. Hammer1, aortic valve repair, membrane, surgical planning, leaflet graft, pericardium ABSTRACT Aortic valve leaflets. Difficulty is largely due to the complex geometry and function of the valve and the lower

  1. Quality electric motor repair: A guidebook for electric utilities

    SciTech Connect (OSTI)

    Schueler, V.; Douglass, J.

    1995-08-01T23:59:59.000Z

    This guidebook provides utilities with a resource for better understanding and developing their roles in relation to electric motor repair shops and the industrial and commercial utility customers that use them. The guidebook includes information and tools that utilities can use to raise the quality of electric motor repair practices in their service territories.

  2. Remote Welding, NDE and Repair of DOE Standardized Canisters

    SciTech Connect (OSTI)

    Eric Larsen; Art Watkins; Timothy R. McJunkin; Dave Pace; Rodney Bitsoi

    2006-05-01T23:59:59.000Z

    The U.S. Department of Energy (DOE) created the National Spent Nuclear Fuel Program (NSNFP) to manage DOE’s spent nuclear fuel (SNF). One of the NSNFP’s tasks is to prepare spent nuclear fuel for storage, transportation, and disposal at the national repository. As part of this effort, the NSNFP developed a standardized canister for interim storage and transportation of SNF. These canisters will be built and sealed to American Society of Mechanical Engineers (ASME) Section III, Division 3 requirements. Packaging SNF usually is a three-step process: canister loading, closure welding, and closure weld verification. After loading SNF into the canisters, the canisters must be seal welded and the welds verified using a combination of visual, surface eddy current, and ultrasonic inspection or examination techniques. If unacceptable defects in the weld are detected, the defective sections of weld must be removed, re-welded, and re-inspected. Due to the high contamination and/or radiation fields involved with this process, all of these functions must be performed remotely in a hot cell. The prototype apparatus to perform these functions is a floor-mounted carousel that encircles the loaded canister; three stations perform the functions of welding, inspecting, and repairing the seal welds. A welding operator monitors and controls these functions remotely via a workstation located outside the hot cell. The discussion describes the hardware and software that have been developed and the results of testing that has been done to date.

  3. Effective Metaroutines for Organizational Problem Solving EFFECTIVE METAROUTINES FOR ORGANIZATIONAL PROBLEM SOLVING

    E-Print Network [OSTI]

    Sobek II, Durward K.

    Effective Metaroutines for Organizational Problem Solving 1 EFFECTIVE METAROUTINES FOR ORGANIZATIONAL PROBLEM SOLVING MANIMAY GHOSH and DURWARD K. SOBEK II* Mechanical and Industrial Engineering@ie.montana.edu * Corresponding Author #12;Effective Metaroutines for Organizational Problem Solving 2 Abstract Short

  4. Computational mechanics

    SciTech Connect (OSTI)

    Goudreau, G.L.

    1993-03-01T23:59:59.000Z

    The Computational Mechanics thrust area sponsors research into the underlying solid, structural and fluid mechanics and heat transfer necessary for the development of state-of-the-art general purpose computational software. The scale of computational capability spans office workstations, departmental computer servers, and Cray-class supercomputers. The DYNA, NIKE, and TOPAZ codes have achieved world fame through our broad collaborators program, in addition to their strong support of on-going Lawrence Livermore National Laboratory (LLNL) programs. Several technology transfer initiatives have been based on these established codes, teaming LLNL analysts and researchers with counterparts in industry, extending code capability to specific industrial interests of casting, metalforming, and automobile crash dynamics. The next-generation solid/structural mechanics code, ParaDyn, is targeted toward massively parallel computers, which will extend performance from gigaflop to teraflop power. Our work for FY-92 is described in the following eight articles: (1) Solution Strategies: New Approaches for Strongly Nonlinear Quasistatic Problems Using DYNA3D; (2) Enhanced Enforcement of Mechanical Contact: The Method of Augmented Lagrangians; (3) ParaDyn: New Generation Solid/Structural Mechanics Codes for Massively Parallel Processors; (4) Composite Damage Modeling; (5) HYDRA: A Parallel/Vector Flow Solver for Three-Dimensional, Transient, Incompressible Viscous How; (6) Development and Testing of the TRIM3D Radiation Heat Transfer Code; (7) A Methodology for Calculating the Seismic Response of Critical Structures; and (8) Reinforced Concrete Damage Modeling.

  5. Problem 6

    E-Print Network [OSTI]

    2015-01-07T23:59:59.000Z

    Feb 17, 2015 ... Did the ball spend more time during its flight going up or going down? A panel in the Mathematics Department publishes a challenging problem ...

  6. Problem 3

    E-Print Network [OSTI]

    2014-08-18T23:59:59.000Z

    Sep 9, 2014 ... COPIES ARE AVAILABLE IN THE MATH LIBRARY. PROBLEM OF ... 150 North University St., West Lafayette, IN 47907-2067. Please include ...

  7. Problem 7

    E-Print Network [OSTI]

    2014-09-23T23:59:59.000Z

    Oct 7, 2014 ... COPIES ARE AVAILABLE IN THE MATH LIBRARY. PROBLEM OF ... 150 North University St., West Lafayette, IN 47907-2067. Please include ...

  8. Problem 2

    E-Print Network [OSTI]

    2014-08-18T23:59:59.000Z

    Sep 2, 2014 ... COPIES ARE AVAILABLE IN THE MATH LIBRARY. PROBLEM OF ... 150 North University St., West Lafayette, IN 47907-2067. Please include ...

  9. A tissue engineering strategy for integrative cartilage repair

    E-Print Network [OSTI]

    Mroszczyk, Keri A

    2014-01-01T23:59:59.000Z

    Tissue engineering for cartilage repair is a promising approach for improving the healing of articular defects, as biomaterials and growth factors can be supplied directly to a focal lesion. However, integrating neo-tissue ...

  10. Optimizing chondrogenic factors and protein delivery methods for cartilage repair

    E-Print Network [OSTI]

    Florine, Emily Marie

    2012-01-01T23:59:59.000Z

    Joint injuries are common and often result in damage to cartilage, which has a limited ability to repair itself. Tissue engineering is a promising approach for improving cartilage healing in which biomaterials and chemical ...

  11. Availability Analysis of Repairable Computer Systems and Stationarity Detection

    E-Print Network [OSTI]

    Sericola, Bruno

    Availability Analysis of Repairable Computer Systems and Stationarity Detection Bruno Sericola AbstractĐPoint availability and expected interval availability are dependability measures respectively in this paper a new algorithm to compute these two availability measures. This algorithm is based

  12. Intermediate hearth repair technique at Thyssen Stahl AG

    SciTech Connect (OSTI)

    Kowalski, W.; Bachhofen, H.J.; Ruether, P.; Ballewski, T. [Thyssen Stahl AG, Duisburg (Germany)

    1996-12-31T23:59:59.000Z

    Nowadays various techniques for the fastest possible intermediate repair and/or emplacement of refractory materials above the tuyere level allow a significant extension of furnace campaign life. The latter are hence now exclusively determined by the service life of the hearth. The improvement of hearth monitoring and the estimation of residual brick strength of the refractory lining on the basis of temperature measurements in the hearth enable the location of individual zones of premature wear. These measurement methods, which were developed by Thyssen Stahl AG, aid the decision to undertake selective repair of the hearth. Three areas of repair are differentiated: taphole zone; hearth wall, localized; and hearth wall, extensive. This hearth repair method is described in this report using the example of hearth refurbishing blast furnace 8, Hamborn.

  13. Repair Sequences in American Learners of German Interlanguage

    E-Print Network [OSTI]

    Wisbey, Evelyn

    2010-04-25T23:59:59.000Z

    This study in Conversation Analysis investigates the organization of other-initiated repair sequences in American learners of German, i.e., it examines how learners deal with troubles in hearing or understanding that they ...

  14. To: Mansueti, Lawrence Subject: RE: Pepco Scheduled Line Repair...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Sent: Monday, January 29, 2007 6:28 PM To: Mansueti, Lawrence Subject: RE: Pepco Scheduled Line Repair Dec. 1-20, 2006 Larry, Regarding the planned line outage,...

  15. Providing protection: Agencies receive funding to repair, upgrade dams

    E-Print Network [OSTI]

    Wythe, Kathy

    2009-01-01T23:59:59.000Z

    Story by Kathy Wythe tx H2O | pg. 26 Providing protection Agencies receive funding to repair, upgrade dams along with local partners, can apply for grant funds, he said. Construction of the dams began through four federal authorizations..., called floodwater retarding structures and built mostly in rural areas during the 1950s to 1970s, are aging and need repairing. Others now protect urban areas that have developed downstream and need upgrading to meet more stringent safety standards...

  16. Exposure Evaluation for Benzene, Lead and Noise in Vehicle and Equipment Repair Shops

    SciTech Connect (OSTI)

    Sweeney, Lynn C.

    2013-04-10T23:59:59.000Z

    An exposure assessment was performed at the equipment and vehicle maintenance repair shops operating at the U. S. Department of Energy Hanford site, in Richland, Washington. The maintenance shops repair and maintain vehicles and equipment used in support of the Hanford cleanup mission. There are three general mechanic shops and one auto body repair shop. The mechanics work on heavy equipment used in construction, cranes, commercial motor vehicles, passenger-type vehicles in addition to air compressors, generators, and farm equipment. Services include part fabrication, installation of equipment, repair and maintenance work in the engine compartment, and tire and brake services. Work performed at the auto body shop includes painting and surface preparation which involves applying body filler and sanding. 8-hour time-weighted-average samples were collected for benzene and noise exposure and task-based samples were collected for lead dust work activities involving painted metal surfaces. Benzene samples were obtained using 3M™ 3520 sampling badges and were analyzed for additional volatile organic compounds. These compounds were selected based on material safety data sheet information for the aerosol products used by the mechanics for each day of sampling. The compounds included acetone, ethyl ether, toluene, xylene, VM&P naphtha, methyl ethyl ketone, and trichloroethylene. Laboratory data for benzene, VM&P naphtha, methyl ethyl ketone and trichloroethylene were all below the reporting detection limit. Airborne concentrations for acetone, ethyl ether, toluene and xylene were all less than 10% of their occupational exposure limit. The task-based samples obtained for lead dusts were submitted for a metal scan analysis to identify other metals that might be present. Laboratory results for lead dusts were all below the reporting detection limit and airborne concentration for the other metals observed in the samples were less than 10% of the occupational exposure limit. Noise dosimetry sampling was performed on a random basis and was representative of the different work activities within the four shops. Twenty three percent of the noise samples exceeded the occupational exposure limit of 85 decibels for an 8-hour time-weightedaverage. Work activities where noise levels were higher included use of impact wrenches and grinding wheels.

  17. Dofasco`s No. 4 blast furnace hearth breakout, repair and rescue

    SciTech Connect (OSTI)

    Donaldson, R.J.; Fischer, A.J.; Sharp, R.M.; Stothart, D.W. [Dofasco Inc., Hamilton, Ontario (Canada)

    1995-12-01T23:59:59.000Z

    On May 5, 1994, after producing 9.5 million metric tons of iron, Dofasco`s No. 4 Blast Furnace experienced a hearth breakout 250 millimeters below the west taphole. The hot metal spill caused a fire resulting in severe damage and 33 days of lost production. During a 26-day period, electrical wiring, water drainage systems and both tapholes were repaired. Recovery from an unprepared furnace stop of this length, with the deadman depleted is difficult. To aid with the rescue Hoogovens-designed oxygen/fuel lances were commissioned. The furnace recovery began with a lance in each taphole and all tuyeres plugged. Six days after startup the furnace was casting into torpedo cars, and after nine days operation had returned to normal. This incident prompted Dofasco to expand the hearth monitoring system to detect and prevent similar occurrences. During the repair, 203 new thermocouples were installed in the hearth, concentrating on the tapholes and elephant foot areas. These thermocouples were installed at various depths and locations to allow heat flux calculations. This hearth monitoring system has already identified other problem areas and provided valuable information about hearth drainage patterns. This information has allowed them to develop control strategies to manage localized problem areas.

  18. Assessment of airplane design, fabrication, and repair

    E-Print Network [OSTI]

    Stolar, Lauren (Lauren Elise)

    2009-01-01T23:59:59.000Z

    Engineering programs are most often classes dedicated to how to design things, while the topic of reverse engineering or problem solving is rarely discussed. This unequal presentation of two sides of the same discipline ...

  19. LENS repair and modification of metal NW components:materials and applications guide.

    SciTech Connect (OSTI)

    Smugeresky, John E. (Sandia National Laboratories, Livermore, CA); Gill, David Dennis; Oberhaus, Jason (BWXT Y-12); Adams, Thad (Savannah River National Laboratory); VanCamp, Chad (Kansas City Plant)

    2006-11-01T23:59:59.000Z

    Laser Engineered Net Shaping{trademark} (LENS{reg_sign}) is a unique, layer additive, metal manufacturing technique that offers the ability to create fully dense metal features and components directly from a computer solid model. LENS offers opportunities to repair and modify components by adding features to existing geometry, refilling holes, repairing weld lips, and many other potential applications. The material deposited has good mechanical properties with strengths typically slightly higher that wrought material due to grain refinement from a quickly cooling weld pool. The result is a material with properties similar to cold worked material, but without the loss in ductility traditionally seen with such treatments. Furthermore, 304L LENS material exhibits good corrosion resistance and hydrogen compatibility. This report gives a background of the LENS process including materials analysis addressing the requirements of a number of different applications. Suggestions are given to aid both the product engineer and the process engineer in the successful utilization of LENS for their applications. The results of testing on interface strength, machinability, weldability, corrosion resistance, geometric effects, heat treatment, and repair strategy testing are all included. Finally, the qualification of the LENS process is briefly discussed to give the user confidence in selecting LENS as the process of choice for high rigor applications. The testing showed LENS components to have capability in repair/modification applications requiring complex castings (W80-3 D-Bottle bracket), thin wall parts requiring metal to be rebuilt onto the part (W87 Firing Set Housing and Y-12 Test Rings), the filling of counterbores for use in reservoir reclamation welding (SRNL hydrogen compatibility study) and the repair of surface defects on pressure vessels (SRNL gas bottle repair). The material is machinable, as testing has shown that LENS deposited material machines similar to that of welded metal. Tool wear is slightly higher in LENS material than in wrought material, but not so much that one would be concerned with increased tooling cost. The LENS process achieved process qualification for the AY1E0125 D-Bottle Bracket from the W80-3 LEP program, and in the effort, also underwent testing in weapons environments. These tests included structural dynamic response testing and drop testing. The LENS deposited parts were compared in these tests with conventionally machined parts and showed equivalency to such an extent that the parts were accepted for use in parallel path subsystem-level weapon environment testing. The evaluation of LENS has shown that the process can be a viable option when either complete metal parts are needed or existing metal parts require modification or repair. The LENS Qualification Technology Investment team successfully investigated new applications for the LENS process and showed that it has great applicability across the Nuclear Weapons Complex as well as in other high rigor applications.

  20. Repairs for damaged bolt holes in continuous fiber reinforced plastics 

    E-Print Network [OSTI]

    Copps, Kevin Daniel

    1992-01-01T23:59:59.000Z

    repair method for damaged bolt holes in such composites. Bolt holes in three types of graphite-epoxy were purposely damaged and then repaired. Each was tested to characterize its static and fatigue behavior. The tests used a special fixture to simulate... composite joints . Bearing-bypass ratio can change the failure mode of bolted composite joints 7 Drilling defects in graphite-epoxy coupons 12 26 The exit side of a IM7/8551-7A 18 ply tape coupon showing the damage due to drilling 27 9 Resin filled...

  1. Microfabricated therapeutic actuator mechanisms

    DOE Patents [OSTI]

    Northrup, Milton A. (Berkeley, CA); Ciarlo, Dino R. (Livermore, CA); Lee, Abraham P. (Walnut Creek, CA); Krulevitch, Peter A. (Los Altos, CA)

    1997-01-01T23:59:59.000Z

    Electromechanical microstructures (microgrippers), either integrated circuit (IC) silicon-based or precision machined, to extend and improve the application of catheter-based interventional therapies for the repair of aneurysms in the brain or other interventional clinical therapies. These micromechanisms can be specifically applied to release platinum coils or other materials into bulging portions of the blood vessels also known as aneurysms. The "micro" size of the release mechanism is necessary since the brain vessels are the smallest in the body. Through a catheter more than one meter long, the micromechanism located at one end of the catheter can be manipulated from the other end thereof. The microgripper (micromechanism) of the invention will also find applications in non-medical areas where a remotely actuated microgripper or similar actuator would be useful or where micro-assembling is needed.

  2. Microfabricated therapeutic actuator mechanisms

    DOE Patents [OSTI]

    Northrup, M.A.; Ciarlo, D.R.; Lee, A.P.; Krulevitch, P.A.

    1997-07-08T23:59:59.000Z

    Electromechanical microstructures (microgrippers), either integrated circuit (IC) silicon-based or precision machined, to extend and improve the application of catheter-based interventional therapies for the repair of aneurysms in the brain or other interventional clinical therapies. These micromechanisms can be specifically applied to release platinum coils or other materials into bulging portions of the blood vessels also known as aneurysms. The ``micro`` size of the release mechanism is necessary since the brain vessels are the smallest in the body. Through a catheter more than one meter long, the micromechanism located at one end of the catheter can be manipulated from the other end thereof. The microgripper (micromechanism) of the invention will also find applications in non-medical areas where a remotely actuated microgripper or similar actuator would be useful or where micro-assembling is needed. 22 figs.

  3. Development of criteria for fatigue repairs in bridge girders damaged by out-of-plane distortion

    E-Print Network [OSTI]

    Wilson, Scott David

    1994-01-01T23:59:59.000Z

    repaired and unrepaired cracks along the longitudinal web-to-flange connection of a plate girder subjected to a linear bending stress to determine if repair by drilling holes is really necessary. The results of the finite element analyses...

  4. DNA Repair Decline During Mouse Spermiogenesis Results in the Accumulation of Heritable DNA Damage

    E-Print Network [OSTI]

    Marchetti, Francesco

    2008-01-01T23:59:59.000Z

    van Buul, D.G. de Rooij, DNA double-strand breaks and gamma-for the transition proteins in DNA strand break repair, FEBSBoissonneault, Stimulation of DNA repair by the spermatidal

  5. Characterization of Mg Binding to the DNA Repair ProteinApurinic...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mg Binding to the DNA Repair Protein ApurinicApyrimidic Endonuclease 1 via Solid-State Mg NMR Spectroscopy. Characterization of Mg Binding to the DNA Repair Protein Apurinic...

  6. DNA repair decline during mouse spermiogenesis results in the accumulation of heritable DNA damage

    E-Print Network [OSTI]

    Marchetti, Francesco

    2008-01-01T23:59:59.000Z

    van Buul, D.G. de Rooij, DNA double-strand breaks and gamma-for the transition proteins in DNA strand break repair, FEBSBoissonneault, Stimulation of DNA repair by the spermatidal

  7. The Need for Language Repair The Reformation Algorithm Discussion Reformation: A Domain-Independent Algorithm

    E-Print Network [OSTI]

    St Andrews, University of

    The Need for Language Repair The Reformation Algorithm Discussion Reformation: A Domain of Edinburgh University of St Andrews, 27th November 2013 #12;The Need for Language Repair The Reformation Algorithm Discussion Outline 1 The Need for Language Repair 2 The Reformation Algorithm 3 Discussion #12;The

  8. Development of quick repairing technique for ceramic burner in hot stove of blast furnace

    SciTech Connect (OSTI)

    Kondo, Atsushi; Doura, Kouji; Nakamura, Hirofumi [Sumitomo Metal Industries, Ltd., Wakayama (Japan). Wakayama Steel Works

    1997-12-31T23:59:59.000Z

    Refractories of ceramic burner in hot stoves at Wakayama No. 4 blast furnace were damaged. There are only three hot stoves, so repairing must be done in a short. Therefore, a quick repairing technique for ceramic burners has been developed, and two ceramic burners were repaired in just 48 hours.

  9. HOW TO REPAIR A SECOND-ORDER SURFACE FOR COMPUTER

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 HOW TO REPAIR A SECOND-ORDER SURFACE FOR COMPUTER EXPERIMENTS BY KRIGING Astrid JOURDAN and analysis of computer experiments have been widely investigated in the past decade. Two approaches seem describes and compares them briefly in order to present a methodology for computer experiments based

  10. Development/Plasticity/Repair Identification of Nicotinic Acetylcholine Receptor Recycling

    E-Print Network [OSTI]

    Alford, Simon

    Development/Plasticity/Repair Identification of Nicotinic Acetylcholine Receptor Recycling and Its, University of Michigan, Ann Arbor, Michigan 48109 In the CNS, receptor recycling is critical for synaptic plasticity; however, the recycling of receptors has never been observed at peripheral synapses. Using a novel

  11. Corrosion Repair and Corrosion Protection of Reinforced Concrete Structures in

    E-Print Network [OSTI]

    Das, Suman

    11/14/2014 1 Corrosion Repair and Corrosion Protection of Reinforced Concrete Structures in Pulp and Paper Mills Vector Construction / Vector Corrosion Technologies www.vectorgroup.com www.vector-corrosion.com Presentation Outline · Introduction · Corrosion of Reinforced Concrete Structures · Protection of Chests

  12. Methods to alter levels of a DNA repair protein

    DOE Patents [OSTI]

    Petrini, John H.; Morgan, William Francis; Maser, Richard Scott; Carney, James Patrick

    2006-10-17T23:59:59.000Z

    An isolated and purified DNA molecule encoding a DNA repair protein, p95, is provided, as is isolated and purified p95. Also provided are methods of detecting p95 and DNA encoding p95. The invention further provides p95 knock-out mice.

  13. Breakthrough Technologies In Vivo Observation of Cavitation and Embolism Repair

    E-Print Network [OSTI]

    Holbrook, N. Michele

    Breakthrough Technologies In Vivo Observation of Cavitation and Embolism Repair Using Magnetic that approximately 10 vessels had cavitated during this time. Leaf water potentials decreased from 1.25 to 2.1 MPa cavitation. Refilling of xylem vessels occurred as soon as the lights were switched off, with the majority

  14. Development/Plasticity/Repair Group I Metabotropic Glutamate Receptors Control

    E-Print Network [OSTI]

    Grau, James

    Development/Plasticity/Repair Group I Metabotropic Glutamate Receptors Control Metaplasticity the spinal cord can support several forms of plasticity, including response­outcome (instrumental) learning. This inhibi- tion of plasticity in spinal learning is itself a form of plasticity that requires i

  15. Complications of Endovascular Repair of Abdominal Aortic Aneurysms: A Review

    SciTech Connect (OSTI)

    Katzen, Barry T. [Baptist Cardiac and Vascular Institute, Baptist Health Systems, Department of Interventional Radiology, Florida (United States)], E-mail: barryk@baptisthealth.net; MacLean, Alexandra A. [New York Hospital-Queens, Department of Surgery (United States)

    2006-12-15T23:59:59.000Z

    The endovascular procedure for repair of abdominal aortic aneurysms has had an enormous impact on the treatment of this challenging disease. Complications, however, do occur and it is important to have a thorough understanding of the array of complications and appropriate management strategies. In this review of endovascular complications, we describe early and late complications paying particular attention to preventive, treatment and surveillance strategies.

  16. Combined Haploinsufficiency for ATM and RAD9 as a Factor in Cell Transformation, Apoptosis, and DNA Lesion Repair Dynamics

    E-Print Network [OSTI]

    Lesion Repair Dynamics Lubomir B. Smilenov, Howard B. Lieberman, Stephen A. Mitchell, Ronald A. Baker

  17. UTILITIES PROBLEMS AND FAILURES Electrical or plumbing failure/Flooding/Water leak/Natural gas

    E-Print Network [OSTI]

    Fernandez, Eduardo

    UTILITIES PROBLEMS AND FAILURES Electrical or plumbing failure/Flooding/Water leak/Natural gas for electrical shock. NOTIFY University Police. What should I do if I smell natural or propane gas? LEAVE/Repair line, 7-6333, or CALL the Campus University Police or Security at (561) 297-3500 or 911

  18. Testing and evaluation of grout repaired tubular members 

    E-Print Network [OSTI]

    Nunn, John Mansfield

    1992-01-01T23:59:59.000Z

    of Failed Weld Seam page 64 65 66 69 73 74 80 82 31 Ideahzed Tubular Dented Member for the Taby, Zhou, and the Parsanejad Methods. . . . . . . . . . . . . . , . 92 32 Dent Geometry for the Elhnas Method 96 33 Experimental Ultimate Capamty vs P... commonly used to repiur damaged tubular members. These include 1 ) welding a sleeve around the outside of the member in the location of the damage, 2 ) applying an externally grouted clamp, and 3 ) applying internal grout Ideally, the repair method...

  19. Waste-audit study: Automotive repairs. Final report

    SciTech Connect (OSTI)

    Toy, W.M.

    1987-05-01T23:59:59.000Z

    This document reports on a waste audit study which investigated and analyzed the automotive-repair industry in California. It assessed current waste-management practices and developed specific on-site and off-site waste-treatment recycling alternatives. The conclusions identify and address illegal disposal practices. Recommendations include the segregation of specific wastes for proper disposal and economic analysis of on-site waste-recycling equipment.

  20. The Mechanical Harvesting of Cotton.

    E-Print Network [OSTI]

    Smith, H. P.; Killough, D. T.; Byrom, M. H.; Scoates, D.; Jones, D. L.

    1932-01-01T23:59:59.000Z

    Stripping Rolls 45 Efficiency of the Texas Station Cotton Harvester --_-_.__---.__--___-.------- 47 --loping Varieties of Cotton to Meet the Needs of Mechanical Har- ~esting 54 owledgments 58 nary 58 List of Patents on Cotton Harvesters ' 60 ,ing ant... patent on a mechanical cotton picker, was apparently taken out in the year 1850. The development of a successful mechanical cotton harvester has been slow, due not only to the mechanical problems en- countered in handling the fiber, but also...

  1. Air PSE (Problem Solving Environment)

    E-Print Network [OSTI]

    Nizkorodov, Sergey

    PSE - 1 Air PSE (Problem Solving Environment) MODELLING OF AIR POLLUTION IN THE LOS ANGELES BASIN WITH AIR PSE Developed by Prof. Donald Dabdub Computational Environmental Sciences Laboratory Mechanical COMPUTER MODELS An air pollution model is a computer program that computes how the different chemical

  2. Senior Mechanical Engineer Company Description

    E-Print Network [OSTI]

    Kostic, Milivoje M.

    for manufacturability and familiarity with six-sigma tools preferred. · Strong analytical and problem solving skills-on experience developing and launching electro-mechanical products, preferable in military or automotive

  3. Time Gravity and Quantum Mechanics

    E-Print Network [OSTI]

    W. G. Unruh

    1993-12-17T23:59:59.000Z

    Time plays different roles in quantum mechanics and gravity. These roles are examined and the problems that the conflict in the roles presents for quantum gravity are briefly summarised.

  4. Using 3D Painting to Build and Repair Parts | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    a part or add material to repair an existing part. Cold spray is part of GE's expanded additive manufacturing toolkit. An error occurred. Unable to execute Javascript. nteneh...

  5. Brain necrosis after fractionated radiation therapy: Is the halftime for repair longer than we thought?

    SciTech Connect (OSTI)

    Bender, Edward T. [Department of Human Oncology, University of Wisconsin-Madison, School of Medicine and Public Health, 600 Highland Avenue, Madison, Wisconsin 53792 (United States)

    2012-11-15T23:59:59.000Z

    Purpose: To derive a radiobiological model that enables the estimation of brain necrosis and spinal cord myelopathy rates for a variety of fractionation schemes, and to compare repair effects between brain and spinal cord. Methods: Sigmoidal dose response relationships for brain radiation necrosis and spinal cord myelopathy are derived from clinical data using nonlinear regression. Three different repair models are considered and the repair halftimes are included as regression parameters. Results: For radiation necrosis, a repair halftime of 38.1 (range 6.9-76) h is found with monoexponential repair, while for spinal cord myelopathy, a repair halftime of 4.1 (range 0-8) h is found. The best-fit alpha beta ratio is 0.96 (range 0.24-1.73)Conclusions: A radiobiological model that includes repair corrections can describe the clinical data for a variety of fraction sizes, fractionation schedules, and total doses. Modeling suggests a relatively long repair halftime for brain necrosis. This study suggests that the repair halftime for late radiation effects in the brain may be longer than is currently thought. If confirmed in future studies, this may lead to a re-evaluation of radiation fractionation schedules for some CNS diseases, particularly for those diseases where fractionated stereotactic radiation therapy is used.

  6. Keynote lecture delivered at the Nat. Conf. on Emerging Trends in Mechanical Engineering, SVNIT, Surat, June 4-5, 2007, pp. 1-10 MODELLING AND ANALYSES OF RURAL ENGINEERING PROBLEMS (MAREP)

    E-Print Network [OSTI]

    Saha, Subir Kumar

    technology, which hinders the overall improvement in quality and efficiency of the said industry products, as more and more international companies are starting their design and production centers in India area called Modeling and Analyses of Rural Engineering Problems (MAREP) to improve the design of rural

  7. Introduction The study of DNA repair mechanisms has been aided by the

    E-Print Network [OSTI]

    in the fission yeast Schizosaccharomyces pombe requires microtubule-dependent oscillatory nuclear movements. These events were initially thought to result from gene conversion (GC) accompanied by crossover (Jager and Philippsen, 1989). However, other studies of direct repeat recombination have shown that deletions commonly

  8. Mechanisms of articular cartilage defect repair in vivo after implantation of stratified cartilaginous tissue

    E-Print Network [OSTI]

    Chawla, Kanika

    2006-01-01T23:59:59.000Z

    diacetate, succinimidyl ester (CFDA, SE) which passivelysuccinimidyl ester (CFDA, SE) [33] which passively diffusesdiacetate, succinimidyl ester (CFDA, SE)[43] which passively

  9. Transcription and mismatch repair in the mechanism of action of the anticancer drug cisplatin

    E-Print Network [OSTI]

    Mello, Jill Ann, 1966-

    1997-01-01T23:59:59.000Z

    cis-Diamminedichloroplatinum(II) (cis-DDP or cisplatin) is a powerful cytotoxin and anticancer therapeutic, used most effectively in the treatment of testicular and ovarian cancers. By contrast, the geometric isomer of ...

  10. Orchestration of cooperative events in DNA synthesis and repair mechanism unraveled by transition path

    E-Print Network [OSTI]

    Schlick, Tamar

    of Chemistry and Courant Institute of Mathematical Sciences, 251 Mercer Street, New York University, New York and energetic details of the con- formational change that precedes the chemical reaction of nucle- otide

  11. Blade reliability collaborative : collection of defect, damage and repair data.

    SciTech Connect (OSTI)

    Ashwill, Thomas D.; Ogilvie, Alistair B.; Paquette, Joshua A.

    2013-04-01T23:59:59.000Z

    The Blade Reliability Collaborative (BRC) was started by the Wind Energy Technologies Department of Sandia National Laboratories and DOE in 2010 with the goal of gaining insight into planned and unplanned O&M issues associated with wind turbine blades. A significant part of BRC is the Blade Defect, Damage and Repair Survey task, which will gather data from blade manufacturers, service companies, operators and prior studies to determine details about the largest sources of blade unreliability. This report summarizes the initial findings from this work.

  12. Rebels, Activists, and Repairers: Youth and Social Change in Africa

    E-Print Network [OSTI]

    Pollock, Colleen

    2011-12-31T23:59:59.000Z

    #3;answer#3;questions#3; (Irvine#3;1978)#3;(i.e.#3;?“what#3;does#3;the#3;ducky#3;say??”)#3;because#3;such#3;questioning#3;indicates#3;a#3;riddle#3;with#3; a#3;trick#3;answer#3;or#3;a#3;direct#3;challenge,#3;and#3;it#3;is#3;considered#3;an#3;insult#3... Date Defended: May 17, 2011 #3; #3; #3; #3; #3; #3; ii #3; The Thesis Committee for Colleen Pollock certifies that this is the approved version of the following thesis: REBELS, ACTIVISTS, AND REPAIRERS: THE ROLE OF YOUTH IN SOCIAL CHANGE...

  13. Repairs for damaged bolt holes in continuous fiber reinforced plastics

    E-Print Network [OSTI]

    Copps, Kevin Daniel

    1992-01-01T23:59:59.000Z

    ANALYSIS Model Definition Analysis Results Comparing Lay-ups Pin-conditions vs. clamping pressure Stress interactions Repair material CONCLUSIONS REFERENCES APPENDIX VITA 21 22 23 24 25 25 25 26 27 27 28 29 30 30 31 33 33 34 34... under pin conditions . 35 16 A modification was made to the test fixture to relieve the high cyclic stresses on the bolt 37 vu 17 When clamping pressure is applied, a normally drilled, unrepaired, fastener hole is stronger and tends to fail in net...

  14. Role of Tissue Repair in Survival from S-(1,2-Dichlorovinyl)-L-Cysteine– Induced Acute Renal Tubular Necrosis in the Mouse

    E-Print Network [OSTI]

    unknown authors

    2003-01-01T23:59:59.000Z

    S-(1,2-Dichlorovinyl)-L-cysteine (DCVC), a model nephrotoxi-cant in mice, causes acute tubular necrosis and death at high doses. Our earlier studies revealed that renal tissue repair was critical for survival in mice with DCVC nephrotoxicity. The ob-jective of this study was to investigate if increasing renal tissue repair could protect mice from the lethal outcome of DCVC. Male Swiss Webster (SW) mice were administered a low dose of DCVC (15 mg/kg, ip) 72 h before injection of a normally lethal dose of DCVC (75 mg/kg, ip); this resulted in 100 % protection against the lethal effect of DCVC. Because DCVC caused twofold decrease in cytosolic and mitochondrial -lyase activity, the possibility that DCVC protection may be caused by decreased bioactivation was examined. Mercuric chloride (HgCl2, 6 mg/kg), a nephrotoxicant with no effect on -lyase activity, was administered 96 h before a lethal dose of DCVC. This also resulted in 100 % protection from the lethal effect of DCVC. In both studies total glutathione was unchanged at any time after the lethal dose of DCVC was admin-istered, obviating the role of glutathione in protection. In both cases the augmented and sustained tissue repair induced by prim-ing dose and documented by 3H-thymidine pulse labeling and immunocytochemistry for proliferating cell nuclear antigen re-sulted in 100 % survival in spite of the extensive renal injury. These findings suggest that stimulation of renal tubular repair by the priming dose, through augmented cell division, and the resistance of new cells to mechanisms of progression of injury, underlies auto- and heteroprotection against DCVC. The molecular mech-anisms may have potential application in pharmacotherapeutic intervention for treatment of acute renal failure.

  15. Role of endonucleases XPF and XPG in nucleotide excision repair of platinated DNA and cisplatin/oxaliplatin cytotoxicity

    E-Print Network [OSTI]

    Graf, Nora

    Resistance of tumor cells to platinum anticancer agents poses a major problem in cancer chemotherapy. One of the mechanisms associated with platinum-based drug resistance is the enhanced capacity of the cell to carry out ...

  16. conference on inverse problems in honor of gunther uhlmann

    E-Print Network [OSTI]

    2012-06-20T23:59:59.000Z

    Jun 18, 2012 ... 20 Ting Zhou, Quantitative thermo-acoustics and related problems. 8 ..... acoustics, fluid mechanics or quantum physics, wherever waves obey ...

  17. & Mechanical Engineering

    E-Print Network [OSTI]

    Zhou, Chongwu

    , robotics, and the development of new tools for integrated approaches to concurrent engineeringAME Aerospace & Mechanical Engineering #12;Aerospace and Mechanical Engineers design complex Engineering (AME) students conduct basic and applied research within and across the usual disciplinary

  18. Repairs to silence Tower bells | The Daily Texan http://dailytexanonline.com/news/2012/09/27/repairs-to-silence-tower-bells 2 of 4 10/2/2012 8:55 AM

    E-Print Network [OSTI]

    John, Lizy Kurian

    Repairs to silence Tower bells | The Daily Texan http://dailytexanonline.com/news/2012/09/27/repairs-to-silence-tower-bells 2 of 4 10/2/2012 8:55 AM #12;Repairs to silence Tower bells | The Daily Texan http://dailytexanonline.com/news/2012/09/27/repairs-to-silence-tower-bells 3 of 4 10/2/2012 8

  19. Cooperative Repair with Minimum-Storage Regenerating Codes for Distributed Storage

    E-Print Network [OSTI]

    Li, Baochun

    Cooperative Repair with Minimum-Storage Regenerating Codes for Distributed Storage Jun Li, Baochun--Distributed storage systems store redundant data to tolerate failures of storage nodes and lost data should be repaired when storage nodes fail. A class of MDS codes, called minimum- storage regenerating (MSR) codes

  20. 4 CONCRETE REPAIR BULLETIN MAY/JUNE2001 Laser Profilometry for

    E-Print Network [OSTI]

    Maerz, Norbert H.

    4 CONCRETE REPAIR BULLETIN MAY/JUNE2001 Laser Profilometry for Concrete Substrate Characterization and resins are non- corrosive, they are ideally suited for the repair and retrofitting of concrete bridges highly upon the quality of the bond between the concrete and the laminate. Experience has shown that when

  1. On the Design of an Interactive, Patient-Specific Surgical Simulator for Mitral Valve Repair

    E-Print Network [OSTI]

    On the Design of an Interactive, Patient-Specific Surgical Simulator for Mitral Valve Repair Neil A repair of the mitral valve is a difficult procedure that is often avoided in favor of less effective valve replacement because of the associated technical challenges facing non-expert surgeons

  2. Bridge Damage and Repair Costs from Hurricane Katrina Jamie Padgett1

    E-Print Network [OSTI]

    Padgett, Jamie Ellen

    Bridge Damage and Repair Costs from Hurricane Katrina Jamie Padgett1 ; Reginald DesRoches2 ; Bryant caused significant damage to the transportation system in the Gulf Coast region. The overall cost to repair or replace the bridges damaged during the hurricane is estimated at over $1 billion. This paper

  3. Bone Marrow Stimulation of the Medial Femoral Condyle Produces Inferior Cartilage and Bone Repair Compared to the Trochlea in a

    E-Print Network [OSTI]

    Buschmann, Michael

    Bone Marrow Stimulation of the Medial Femoral Condyle Produces Inferior Cartilage and Bone Repair femoral condylar (MFC) versus femoral trochlear (TR) defects 3 months after bone marrow stimulation: cartilage repair; medial femoral condyle; trochlea; bone marrow stimulation; meniscus degeneration Articular

  4. ITERATIVE REPAIR PLANNING FOR SPACECRAFT OPERATIONS USING THE ASPEN SYSTEM Gregg Rabideau, Russell Knight, Steve Chien, Alex Fukunaga, Anita Govindjee

    E-Print Network [OSTI]

    Schaffer, Steven

    ITERATIVE REPAIR PLANNING FOR SPACECRAFT OPERATIONS USING THE ASPEN SYSTEM Gregg Rabideau, Russell and Planning Environment (ASPEN). ASPEN encodes complex spacecraft knowledge of operability constraints, flight generation of low level spacecraft sequences. Using a technique called iterative repair, ASPEN classifies

  5. Repair of gamma-ray-induced DNA base damage in xeroderma pigmentosum cells

    SciTech Connect (OSTI)

    Fornace, A.J. Jr.; Dobson, P.P.; Kinsella, T.J.

    1986-04-01T23:59:59.000Z

    The repair of DNA damage produced by /sup 137/Cs gamma irradiation was measured with a preparation from Micrococcus luteus containing DNA damage-specific endonucleases in combination with alkaline elution. The frequency of these endonuclease sensitive sites (ESS) was determined after 54 or 110 Gy of oxic irradiation in normal and xeroderma pigmentosum (XP) fibroblasts from complementation groups A, C, D, and G. Repair was rapid in all cell strains with greater than 50% repair after 1.5 h of repair incubation. At later repair times, 12-17 h, more ESS remained in XP than in normal cells. The frequency of excess ESS in XP cells was approximately 0.04 per 10(9) Da of DNA per Gy which was equivalent to 10% of the initial ESS produced. The removal of ESS was comparable in XP cells with normal radiosensitivity and XP3BR cells which have been reported to be moderately radiosensitive.

  6. Mechanical Engineer

    Broader source: Energy.gov [DOE]

    A successful candidate in this position will handle assignments involving multiple simultaneous problems that require extensive and penetrating investigation to explore new technology, and to...

  7. Evaluating indoor exposure modeling alternatives for LCA: A case study in the vehicle repair industry

    SciTech Connect (OSTI)

    Demou, Evangelia; Hellweg, Stefanie; Wilson, Michael P.; Hammond, S. Katharine; McKone, Thomas E.

    2009-05-01T23:59:59.000Z

    We evaluated three exposure models with data obtained from measurements among workers who use"aerosol" solvent products in the vehicle repair industry and with field experiments using these products to simulate the same exposure conditions. The three exposure models were the: 1) homogeneously-mixed-one-box model, 2) multi-zone model, and 3) eddy-diffusion model. Temporally differentiated real-time breathing zone volatile organic compound (VOC) concentration measurements, integrated far-field area samples, and simulated experiments were used in estimating parameters, such as emission rates, diffusivity, and near-field dimensions. We assessed differences in model input requirements and their efficacy for predictive modeling. The One-box model was not able to resemble the temporal profile of exposure concentrations, but it performed well concerning time-weighted exposure over extended time periods. However, this model required an adjustment for spatial concentration gradients. Multi-zone models and diffusion-models may solve this problem. However, we found that the reliable use of both these models requires extensive field data to appropriately define pivotal parameters such as diffusivity or near-field dimensions. We conclude that it is difficult to apply these models for predicting VOC exposures in the workplace. However, for comparative exposure scenarios in life-cycle assessment they may be useful.

  8. Symmetry in Scheduling Problems

    E-Print Network [OSTI]

    2010-11-16T23:59:59.000Z

    Nov 16, 2010 ... Using operating room and power generator scheduling problems ... suggested that a class of highly symmetric covering problems called Steiner Triple Systems ... The structure of symmetry present in these problems allow for.

  9. A physical approach to Tsirelson's problem

    E-Print Network [OSTI]

    Miguel Navascues; Tom Cooney; David Perez-Garcia; Ignacio Villanueva

    2011-05-17T23:59:59.000Z

    Tsirelson's problem deals with how to model separate measurements in quantum mechanics. In addition to its theoretical importance, the resolution of Tsirelson's problem could have great consequences for device independent quantum key distribution and certified randomness. Unfortunately, understanding present literature on the subject requires a heavy mathematical background. In this paper, we introduce quansality, a new theoretical concept that allows to reinterpret Tsirelson's problem from a foundational point of view. Using quansality as a guide, we recover all known results on Tsirelson's problem in a clear and intuitive way.

  10. Method of tissue repair using a composite material

    DOE Patents [OSTI]

    Hutchens, Stacy A; Woodward, Jonathan; Evans, Barbara R; O'Neill, Hugh M

    2014-03-18T23:59:59.000Z

    A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.

  11. Neurological Complications Following Endoluminal Repair of Thoracic Aortic Disease

    SciTech Connect (OSTI)

    Morales, J. P.; Taylor, P. R.; Bell, R. E.; Chan, Y. C. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Vascular Surgery (United Kingdom); Sabharwal, T. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Interventional Radiology (United Kingdom); Carrell, T. W. G. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Vascular Surgery (United Kingdom); Reidy, J. F. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Interventional Radiology (United Kingdom)], E-mail: John.Reidy@gstt.nhs.uk

    2007-09-15T23:59:59.000Z

    Open surgery for thoracic aortic disease is associated with significant morbidity and the reported rates for paraplegia and stroke are 3%-19% and 6%-11%, respectively. Spinal cord ischemia and stroke have also been reported following endoluminal repair. This study reviews the incidence of paraplegia and stroke in a series of 186 patients treated with thoracic stent grafts. From July 1997 to September 2006, 186 patients (125 men) underwent endoluminal repair of thoracic aortic pathology. Mean age was 71 years (range, 17-90 years). One hundred twenty-eight patients were treated electively and 58 patients had urgent procedures. Anesthesia was epidural in 131, general in 50, and local in 5 patients. Seven patients developed paraplegia (3.8%; two urgent and five elective). All occurred in-hospital apart from one associated with severe hypotension after a myocardial infarction at 3 weeks. Four of these recovered with cerebrospinal fluid (CSF) drainage. One patient with paraplegia died and two had permanent neurological deficit. The rate of permanent paraplegia and death was 1.6%. There were seven strokes (3.8%; four urgent and three elective). Three patients made a complete recovery, one had permanent expressive dysphasia, and three died. The rate of permanent stroke and death was 2.1%. Endoluminal treatment of thoracic aortic disease is an attractive alternative to open surgery; however, there is still a risk of paraplegia and stroke. Permanent neurological deficits and death occurred in 3.7% of the patients in this series. We conclude that prompt recognition of paraplegia and immediate insertion of a CSF drain can be an effective way of recovering spinal cord function and improving the prognosis.

  12. Development and validation of bonded composite doubler repairs for commercial aircraft.

    SciTech Connect (OSTI)

    Roach, Dennis Patrick; Rackow, Kirk A.

    2007-07-01T23:59:59.000Z

    A typical aircraft can experience over 2,000 fatigue cycles (cabin pressurizations) and even greater flight hours in a single year. An unavoidable by-product of aircraft use is that crack, impact, and corrosion flaws develop throughout the aircraft's skin and substructure elements. Economic barriers to the purchase of new aircraft have placed even greater demands on efficient and safe repair methods. The use of bonded composite doublers offers the airframe manufacturers and aircraft maintenance facilities a cost effective method to safely extend the lives of their aircraft. Instead of riveting multiple steel or aluminum plates to facilitate an aircraft repair, it is now possible to bond a single Boron-Epoxy composite doubler to the damaged structure. The FAA's Airworthiness Assurance Center at Sandia National Labs (AANC), Boeing, and Federal Express completed a pilot program to validate and introduce composite doubler repair technology to the U.S. commercial aircraft industry. This project focused on repair of DC-10 fuselage structure and its primary goal was to demonstrate routine use of this repair technology using niche applications that streamline the design-to-installation process. As composite doubler repairs gradually appear in the commercial aircraft arena, successful flight operation data is being accumulated. These commercial aircraft repairs are not only demonstrating the engineering and economic advantages of composite doubler technology but they are also establishing the ability of commercial maintenance depots to safely adopt this repair technique. This report presents the array of engineering activities that were completed in order to make this technology available for widespread commercial aircraft use. Focused laboratory testing was conducted to compliment the field data and to address specific issues regarding damage tolerance and flaw growth in composite doubler repairs. Fatigue and strength tests were performed on a simulated wing repair using a substandard design and a flawed installation. In addition, the new Sol-Gel surface preparation technique was evaluated. Fatigue coupon tests produced Sol-Gel results that could be compared with a large performance database from conventional, riveted repairs. It was demonstrated that not only can composite doublers perform well in severe off-design conditions (low doubler stiffness and presence of defects in doubler installation) but that the Sol-Gel surface preparation technique is easier and quicker to carry out while still producing optimum bonding properties. Nondestructive inspection (NDI) methods were developed so that the potential for disbond and delamination growth could be monitored and crack growth mitigation could be quantified. The NDI methods were validated using full-scale test articles and the FedEx aircraft installations. It was demonstrated that specialized NDI techniques can detect flaws in composite doubler installations before they reach critical size. Probability of Detection studies were integrated into the FedEx training in order to quantify the ability of aircraft maintenance depots to properly monitor these repairs. In addition, Boeing Structural Repair and Nondestructive Testing Manuals were modified to include composite doubler repair and inspection procedures. This report presents the results from the FedEx Pilot Program that involved installation and surveillance of numerous repairs on operating aircraft. Results from critical NDI evaluations are reported in light of damage tolerance assessments for bonded composite doublers. This work has produced significant interest from airlines and aircraft manufacturers. The successful Pilot Program produced flight performance history to establish the durability of bonded composite patches as a permanent repair on commercial aircraft structures. This report discusses both the laboratory data and Pilot Program results from repair installations on operating aircraft to introduce composite doubler repairs into mainstream commercial aircraft use.

  13. A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGT

    E-Print Network [OSTI]

    Dinner, Aaron

    A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGT Jie serve as a paradigm for the many nucleotide-flipping proteins that regulate genes and repair DNA in all trajectories of molecu- larly rare events now enable us to elucidate a pathway for nucleotide flipping by AGT

  14. DNA Repair Alterations in Children With Pediatric Malignancies: Novel Opportunities to Identify Patients at Risk for High-Grade Toxicities

    SciTech Connect (OSTI)

    Ruebe, Claudia E., E-mail: claudia.ruebe@uks.e [Department of Radiation Oncology, Saarland University, Homburg/Saar (Germany); Fricke, Andreas; Schneider, Ruth; Simon, Karin; Kuehne, Martin; Fleckenstein, Jochen [Department of Radiation Oncology, Saarland University, Homburg/Saar (Germany); Graeber, Stefan [Institute of Medical Biometrics, Epidemiology and Medical Informatics, Saarland University, Homburg/Saar (Germany); Graf, Norbert [Department of Pediatric Hematology and Oncology, Saarland University, Homburg/Saar (Germany); Ruebe, Christian [Department of Radiation Oncology, Saarland University, Homburg/Saar (Germany)

    2010-10-01T23:59:59.000Z

    Purpose: To evaluate, in a pilot study, the phosphorylated H2AX ({gamma}H2AX) foci approach for identifying patients with double-strand break (DSB) repair deficiencies, who may overreact to DNA-damaging cancer therapy. Methods and Materials: The DSB repair capacity of children with solid cancers was analyzed compared with that of age-matched control children and correlated with treatment-related normal-tissue responses (n = 47). Double-strand break repair was investigated by counting {gamma}H2AX foci in blood lymphocytes at defined time points after irradiation of blood samples. Results: Whereas all healthy control children exhibited proficient DSB repair, 3 children with tumors revealed clearly impaired DSB repair capacities, and 2 of these repair-deficient children developed life-threatening or even lethal normal-tissue toxicities. The underlying mutations affecting regulatory factors involved in DNA repair pathways were identified. Moreover, significant differences in mean DSB repair capacity were observed between children with tumors and control children, suggesting that childhood cancer is based on genetic alterations affecting DSB repair function. Conclusions: Double-strand break repair alteration in children may predispose to cancer formation and may affect children's susceptibility to normal-tissue toxicities. Phosphorylated H2AX analysis of blood samples allows one to detect DSB repair deficiencies and thus enables identification of children at risk for high-grade toxicities.

  15. CtIP tetramer assembly is required for DNA-end resection and repair

    E-Print Network [OSTI]

    Davies, Owen R.; Forment, Josep V.; Sun, Meidai; Belotserkovskaya, Rimma; Coates, Julia; Galanty, Yaron; Demir, Mukerrem; Morton, Christopher; Rzechorzek, Neil; Jackson, Stephen P.; Pellegrini, Luca

    2015-01-05T23:59:59.000Z

    1     CtIP tetramer assembly is required for DNA-end resection and repair Owen R. Davies1,4*, Josep V. Forment1,2,3*, Meidai Sun1, Rimma Belotserkovskaya1,2, Julia Coates1,2, Yaron Galanty1,2, Mukerrem Demir1,2, Christopher Morton1... that a CtIP tetramer architecture is essential for effective DSB repair by homologous recombination. Keywords CtIP/RBBP8, double-strand DNA break repair, DNA-end resection, gene conversion, homologous recombination. 3...

  16. Functional Characterization of Kansl2 and Its Role in Mitochondrial DNA Repair and Maintenance

    E-Print Network [OSTI]

    Liau, Wei-Siang

    2012-01-01T23:59:59.000Z

    understanding of the maintenance and repair of the mtDNA,A is necessary for mtDNA maintenance and embryogenesis in1997). Mitochondrial DNA maintenance in vertebrates. Annu

  17. Plug repairs of marine glass fiber / vinyl ester laminates subjected to uniaxial tension

    E-Print Network [OSTI]

    Michelis, Alexandros

    2009-01-01T23:59:59.000Z

    Glass fiber/vinyl ester composite laminates are currently being used and proposed for the hulls, bulkheads, and superstructures of large ships. This thesis examines the effectiveness of the repair of such laminates using ...

  18. Review of Maintenance and Repair Times for Components in Technological Facilities

    SciTech Connect (OSTI)

    L. C. Cadwallader

    2012-11-01T23:59:59.000Z

    This report is a compilation of some unique component repair time data and it also presents citations of more extensive reports where lists of repair times can be found. This collection of information should support analysts who seek to quantify maintainability and availability of high technology and nuclear energy production systems. While there are newer sources of repair time information, most, if not all, of the newer sources are proprietary and cannot be shared. This report offers data that, while older, is openly accessible and can serve as reasonable estimates of repair times, at least for initial studies. Some times were found for maintenance times in radiation environments, and some guidance for multiplicative factors to use to account for work in contamination areas.

  19. Modeling and centralization of strategic inventory for repairable and long lead-time spare parts

    E-Print Network [OSTI]

    Duncan, Tyeliah Elaine

    2011-01-01T23:59:59.000Z

    This thesis develops an optimal inventory model for repairable and long leadtime spare parts for an Engine overhaul business. In addition, it presents a business case for centralization of inventory. Pratt & Whitney purchased ...

  20. Tiny Terminators: New Micro-Robots Assemble, Repair Themselves and Are Surprisingly Strong

    Broader source: Energy.gov [DOE]

    Tiny robots that can assemble and repair themselves? Watch a video of Argonne National Laboratory's micro-robots that easily perform tasks that can challenge other robots, including moving objects that are larger than themselves.

  1. Consistency Management with Repair Actions Christian Nentwich, Wolfgang Emmerich and Anthony Finkelstein

    E-Print Network [OSTI]

    van der Hoek, André

    Consistency Management with Repair Actions Christian Nentwich, Wolfgang Emmerich and Anthony Finkelstein Department of Computer Science University College London Gower Street, London WC1E 6BT, UK {c.nentwich,w.emmerich

  2. Use of CFRP Overlays to Repair Fatigue Damage in Steel Bridge Girders and Components

    E-Print Network [OSTI]

    Gangel, Regan Elisabeth

    2012-05-31T23:59:59.000Z

    Fatigue damage in steel girder bridges built prior to the mid-1980s is common due to distortion-induced fatigue. Different repair techniques have been developed and implemented to retrofit bridges of this era with existing fatigue damage...

  3. Community-Minded Interns at Savannah River Site Help Area Residents in Need with Home Repairs

    Broader source: Energy.gov [DOE]

    AIKEN, S.C. – More than two dozen college interns who worked at the Savannah River Site (SRS) this summer joined other volunteers and headed into area neighborhoods to help people in need with home repairs.

  4. aneurysm repair experience: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The most basic theoretical challenge for understanding low energy nuclear reaction (LENR) and transmutation reaction (LETR) in condensed matters is to find mechanisms by which...

  5. RESTORING A DAMAGED 16-YEAR -OLD INSULATING POLYMER CONCRETE DIKE OVERLAY: REPAIR MATERIALS AND TECHNOLOGIES.

    SciTech Connect (OSTI)

    SUGAMA,T.

    2007-01-01T23:59:59.000Z

    The objective of this program was to design and formulate organic polymer-based material systems suitable for repairing and restoring the overlay panels of insulating lightweight polymer concrete (ILPC) from the concrete floor and slope wall of a dike at KeySpan liquefied natural gas (LNG) facility in Greenpoint, Brooklyn, NY, just over sixteen years ago. It also included undertaking a small-scale field demonstration to ensure that the commercial repairing technologies were applicable to the designed and formulated materials.

  6. Problems on Integration.

    E-Print Network [OSTI]

    2007-07-02T23:59:59.000Z

    INTEGRATION. V2.0. 1. One-liners. Problem 1. True of false: If f is a non-negative function defined on. R and. ?. R f dx < ?, then lim|x|?? f(x) = 0. Problem 2.

  7. In situ repair of a failed compression fitting

    DOE Patents [OSTI]

    Wolbert, R.R.; Jandrasits, W.G.

    1985-08-05T23:59:59.000Z

    A method and apparatus for the in situ repair of a failed compression fitting is provided. Initially, a portion of a guide tube is inserted coaxially in the bore of the compression fitting and locked therein. A close fit dethreading device is then coaxially mounted on the guide tube to cut the threads from the fitting. Thereafter, the dethreading device and guide tube are removed and a new fitting is inserted onto the dethreaded fitting with the body of the new fitting overlaying the dethreaded portion. Finally, the main body of the new fitting is welded to the main body of the old fitting whereby a new threaded portion of the replacement fitting is precisely coaxial with the old threaded portion. If needed, a bushing is located on the dethreaded portion which is sized to fit snugly between the dethreaded portion and the new fitting. Preferably, the dethreading device includes a cutting tool which is moved incrementally in a radial direction whereby the threads are cut from the threaded portion of the failed fitting in increments.

  8. In situ repair of a failed compression fitting

    DOE Patents [OSTI]

    Wolbert, Ronald R. (McKees Rocks, PA); Jandrasits, Walter G. (Pittsburgh, PA)

    1986-01-01T23:59:59.000Z

    A method and apparatus for the in situ repair of a failed compression fitg is provided. Initially, a portion of a guide tube is inserted coaxially in the bore of the compression fitting and locked therein. A close fit dethreading device is then coaxially mounted on the guide tube to cut the threads from the fitting. Thereafter, the dethreading device and guide tube are removed and a new fitting is inserted onto the dethreaded fitting with the body of the new fitting overlaying the dethreaded portion. Finally, the main body of the new fitting is welded to the main body of the old fitting whereby a new threaded portion of the replacement fitting is precisely coaxial with the old threaded portion. If needed, a bushing is located on the dethreaded portion which is sized to fit snugly between the dethreaded portion and the new fitting. Preferably, the dethreading device includes a cutting tool which is moved incrementally in a radial direction whereby the threads are cut from the threaded portion of the failed fitting in increments.

  9. Final Report for DOE Grant DE-FG02-03ER25579; Development of High-Order Accurate Interface Tracking Algorithms and Improved Constitutive Models for Problems in Continuum Mechanics with Applications to Jetting

    SciTech Connect (OSTI)

    Puckett, Elbridge Gerry [U.C. Davis, Department of Mathematics; Miller, Gregory Hale [.C. Davis, Department of Chemical Engineering

    2012-10-14T23:59:59.000Z

    Much of the work conducted under the auspices of DE-FG02-03ER25579 was characterized by an exceptionally close collaboration with researchers at the Lawrence Berkeley National Laboratory (LBNL). For example, Andy Nonaka, one of Professor Miller's graduate students in the Department of Applied Science at U. C. Davis (UCD) wrote his PhD thesis in an area of interest to researchers in the Applied Numerical Algorithms Group (ANAG), which is a part of the National Energy Research Supercomputer Center (NERSC) at LBNL. Dr. Nonaka collaborated closely with these researchers and subsequently published the results of this collaboration jointly with them, one article in a peer reviewed journal article and one paper in the proceedings of a conference. Dr. Nonaka is now a research scientist in the Center for Computational Sciences and Engineering (CCSE), which is also part of the National Energy Research Supercomputer Center (NERSC) at LBNL. This collaboration with researchers at LBNL also included having one of Professor Puckett's graduate students in the Graduate Group in Applied Mathematics (GGAM) at UCD, Sarah Williams, spend the summer working with Dr. Ann Almgren, who is a staff scientist in CCSE. As a result of this visit Sarah decided work on a problem suggested by the head of CCSE, Dr. John Bell, for her PhD thesis. Having finished all of the coursework and examinations required for a PhD, Sarah stayed at LBNL to work on her thesis under the guidance of Dr. Bell. Sarah finished her PhD thesis in June of 2007. Writing a PhD thesis while working at one of the University of California (UC) managed DOE laboratories is long established tradition at UC and Professor Puckett has always encouraged his students to consider doing this. Another one of Professor Puckett's graduate students in the GGAM at UCD, Christopher Algieri, was partially supported with funds from DE-FG02-03ER25579 while he wrote his MS thesis in which he analyzed and extended work originally published by Dr. Phillip Colella, the head of ANAG, and some of his colleagues. Chris Algieri is now employed as a staff member in Dr. Bill Collins' Climate Science Department in the Earth Sciences Division at LBNL working with computational models of climate change. Finally, it should be noted that the work conducted by Professor Puckett and his students Sarah Williams and Chris Algieri and described in this final report for DOE grant # DE-FC02-03ER25579 is closely related to work performed by Professor Puckett and his students under the auspices of Professor Puckett's DOE SciDAC grant DE-FC02-01ER25473 An Algorithmic and Software Framework for Applied Partial Differential Equations: A DOE SciDAC Integrated Software Infrastructure Center (ISIC). Dr. Colella was the lead PI for this SciDAC grant, which was comprised of several research groups from DOE national laboratories and five university PI's from five different universities. In theory Professor Puckett tried to use funds from the SciDAC grant to support work directly involved in implementing algorithms developed by members of his research group at UCD as software that might be of use to Puckett's SciDAC CoPIs. (For example, see the work reported in Section 2.2.2 of this final report.) However, since there is considerable lead time spent developing such algorithms before they are ready to become `software' and research plans and goals change as the research progresses, Professor Puckett supported each member of his research group partially with funds from the SciDAC APDEC ISIC DE-FC02-01ER25473 and partially with funds from this DOE MICS grant DE-FC02-03ER25579. This has necessarily resulted in a significant overlap of project areas that were funded by both grants. In particular, both Sarah Williams and Chris Algieri were supported partially with funds from grant # DE-FG02-03ER25579, for which this is the final report, and in part with funds from Professor Puckett's DOE SciDAC grant # DE-FC02-01ER25473. For example, Sarah Williams received support from DE-FC02- 01ER25473 and DE-FC02-03ER25579, both while at UCD taking cla

  10. Computational mechanics

    SciTech Connect (OSTI)

    Raboin, P J

    1998-01-01T23:59:59.000Z

    The Computational Mechanics thrust area is a vital and growing facet of the Mechanical Engineering Department at Lawrence Livermore National Laboratory (LLNL). This work supports the development of computational analysis tools in the areas of structural mechanics and heat transfer. Over 75 analysts depend on thrust area-supported software running on a variety of computing platforms to meet the demands of LLNL programs. Interactions with the Department of Defense (DOD) High Performance Computing and Modernization Program and the Defense Special Weapons Agency are of special importance as they support our ParaDyn project in its development of new parallel capabilities for DYNA3D. Working with DOD customers has been invaluable to driving this technology in directions mutually beneficial to the Department of Energy. Other projects associated with the Computational Mechanics thrust area include work with the Partnership for a New Generation Vehicle (PNGV) for ''Springback Predictability'' and with the Federal Aviation Administration (FAA) for the ''Development of Methodologies for Evaluating Containment and Mitigation of Uncontained Engine Debris.'' In this report for FY-97, there are five articles detailing three code development activities and two projects that synthesized new code capabilities with new analytic research in damage/failure and biomechanics. The article this year are: (1) Energy- and Momentum-Conserving Rigid-Body Contact for NIKE3D and DYNA3D; (2) Computational Modeling of Prosthetics: A New Approach to Implant Design; (3) Characterization of Laser-Induced Mechanical Failure Damage of Optical Components; (4) Parallel Algorithm Research for Solid Mechanics Applications Using Finite Element Analysis; and (5) An Accurate One-Step Elasto-Plasticity Algorithm for Shell Elements in DYNA3D.

  11. An internal seal for repairing natural gas mains

    E-Print Network [OSTI]

    Cooper, Samuel A.

    1984-01-01T23:59:59.000Z

    Joint leakage from low pressure natural gas distribution mains (typical value: 0.25 ft[superscript 3] at 6 inwg gas pressure) is a persistent source of maintenance problems for utitlites. External encapsulation is the usual ...

  12. The Repair Paradigm: New Algorithms and Applications to Compressible Flow

    E-Print Network [OSTI]

    , momentum and total energy. In this way, positive density and internal energy are achieved as a side effect, and an interacting 2D blast wave problem. The latter is done with a Lagrangian code for which rezoning, remapping

  13. Relocation and repair of the National Geotechnical Centrifuge. Final report

    SciTech Connect (OSTI)

    Cheney, J.A. [California Univ., Davis, CA (United States). Center for Geotechnical Modeling

    1994-10-01T23:59:59.000Z

    In January of 1984, the large geotechnical centrifuge located at NASA Ames Research Center, was in the first stages of operational checkout when the main thrust bearing of the large D.C. drive motor failed. After many months of investigation and proposals for repair of the facility, it became evident that it would be far more advantageous to the engineering community to remove those components of the centrifuge that were undamaged to the Davis campus and replace the drive system completely. The large centrifuge had cost over 2 million dollars to build, and it would have been irresponsible to simply scrap it. Recognizing this fact, funds were solicited and received from various sources, and Beam Engineering Inc. was contracted to design and construct the centrifuge at its new location. The University of California contributed a quarter of a million dollars and Tyndall Air Force Base, through Los Alamos National Laboratory, contributed $140,000. There were funds also contributed by LANL, LLNL, US Navy and NSF. The first stage in the phased development of the newly located centrifuge is nearing completion, which prompts the writing of this report. By the time that this report reaches the reader the first runs of the centrifuge will have been completed. The present report describes the present capability of the centrifuge and the plans for upgrading as time goes on. Several pilot studies were carried out. The experiments involved (1) the effects of nearby explosions on buried thin walled containers and (2) the advection and dispersion of toxic waste water through soils.

  14. Essays on dynamic games and mechanism design

    E-Print Network [OSTI]

    Lang, Ruitian

    2014-01-01T23:59:59.000Z

    The dissertation considers three topics in dynamic games and mechanism design. In both problems, asymmetric information causes inefficiency in production and allocation. The first chapter considers the inefficiency from ...

  15. Development of a Mechanics Reasoning Inventory

    E-Print Network [OSTI]

    Pawl, Andrew

    2012-01-01T23:59:59.000Z

    Strategic knowledge is required to appropriately organize procedures and concepts to solve problems. We are developing a standardized instrument assessing strategic knowledge in the domain of introductory mechanics. This ...

  16. An examination of the mechanisms of incubation

    E-Print Network [OSTI]

    Kohn, Nicholas William

    2007-04-25T23:59:59.000Z

    Several hypotheses have been offered to explain the mechanisms involved in incubation, the phenomenon in which resolution of a problem benefits more from interruption than continuous solution attempts. The predictions of three hypotheses were tested...

  17. WHERE MULTIFUNCTIONAL DNA REPAIR PROTEINS MEET: MAPPING THE INTERACTION DOMAINS BETWEEN XPG AND WRN

    SciTech Connect (OSTI)

    Rangaraj, K.; Cooper, P.K.; Trego, K.S.

    2009-01-01T23:59:59.000Z

    The rapid recognition and repair of DNA damage is essential for the maintenance of genomic integrity and cellular survival. Multiple complex and interconnected DNA damage responses exist within cells to preserve the human genome, and these repair pathways are carried out by a specifi c interplay of protein-protein interactions. Thus a failure in the coordination of these processes, perhaps brought about by a breakdown in any one multifunctional repair protein, can lead to genomic instability, developmental and immunological abnormalities, cancer and premature aging. This study demonstrates a novel interaction between two such repair proteins, Xeroderma pigmentosum group G protein (XPG) and Werner syndrome helicase (WRN), that are both highly pleiotropic and associated with inherited genetic disorders when mutated. XPG is a structure-specifi c endonuclease required for the repair of UV-damaged DNA by nucleotide excision repair (NER), and mutations in XPG result in the diseases Xeroderma pigmentosum (XP) and Cockayne syndrome (CS). A loss of XPG incision activity results in XP, whereas a loss of non-enzymatic function(s) of XPG causes CS. WRN is a multifunctional protein involved in double-strand break repair (DSBR), and consists of 3’–5’ DNA-dependent helicase, 3’–5’ exonuclease, and single-strand DNA annealing activities. Nonfunctional WRN protein leads to Werner syndrome, a premature aging disorder with increased cancer incidence. Far Western analysis was used to map the interacting domains between XPG and WRN by denaturing gel electrophoresis, which separated purifi ed full length and recombinant XPG and WRN deletion constructs, based primarily upon the length of each polypeptide. Specifi c interacting domains were visualized when probed with the secondary protein of interest which was then detected by traditional Western analysis using the antibody of the secondary protein. The interaction between XPG and WRN was mapped to the C-terminal region of XPG as well as the C-terminal region of WRN. The physical interaction between XPG and WRN links NER, (made evident by the disease XP) with DSBR, which imparts additional knowledge of the overlapping nature of these two proteins and the previously distinct DNA repair pathways they are associated with. Since genomic integrity is constantly threatened by both endogenous and exogenous (internal and external) damage, understanding the roles of these proteins in coordinating DNA repair processes with replication will signifi cantly further understanding how defects instigate physiological consequences in response to various DNA damaging sources. This ultimately contributes to our understanding of cancer and premature aging.

  18. Problem 5 - Purdue University

    E-Print Network [OSTI]

    2011-09-19T23:59:59.000Z

    Sep 20, 2011 ... (Neglect air resistance.) A panel in the Mathematics Department publishes a challenging problem once a week and invites college ...

  19. PROBLEM OF THE WEEK

    E-Print Network [OSTI]

    **This problem is a modi?ed version of one proposed by Michael Roach of New Millemium. Building Systems, who has an engineering application for it.

  20. Drinking Water Problems: Copper 

    E-Print Network [OSTI]

    Dozier, Monty; McFarland, Mark L.; Lesikar, Bruce J.

    2006-01-25T23:59:59.000Z

    High levels of copper in drinking water can cause health problems. This publication explains the effects of copper in water and methods of removing it. 4 pp....

  1. Drinking Water Problems: Copper

    E-Print Network [OSTI]

    Dozier, Monty; McFarland, Mark L.; Lesikar, Bruce J.

    2006-01-25T23:59:59.000Z

    High levels of copper in drinking water can cause health problems. This publication explains the effects of copper in water and methods of removing it. 4 pp....

  2. The role of mismatch repair in mediating cellular sensitivity to cisplatin : the Escherichia coli methyl-directed repair paradigm

    E-Print Network [OSTI]

    Robbins, Jennifer L

    2006-01-01T23:59:59.000Z

    The anticancer drug cisplatin is in widespread use but its mechanism of action is only poorly understood. Moreover, human cancers acquire resistance to the drug, which limits its clinical utility. A paradox in the field ...

  3. Do VFD Energy Savings Outweigh Potential Mechanical Problems?

    E-Print Network [OSTI]

    Martin, V.

    of power electronic components. Commercialization has naturally followed and many motor applications which were traditionally fixed speed are now operating on variable speed. As with any equipment addition or change that has a technical impact on its...

  4. A nonlinear variational problem in relativistic quan-tum mechanics

    E-Print Network [OSTI]

    Boyer, Edmond

    electrodynamics, vacuum polarization Proceedings of the 6th European Congress of Mathematics, Krakow (Poland/anti-particle pair by providing a sufficient amount of energy to the vacuum. From Einstein's famous relation, this energy must be at least 2 × mc2 . Because one can create matter from energy, the vacuum cannot be seen

  5. A novel role for Gadd45? in base excision repair: Modulation of APE1 activity by the direct interaction of Gadd45? with PCNA

    SciTech Connect (OSTI)

    Kim, Hye Lim [Department of Life Science, Dongguk University, 30 Pildong-ro 1-gil, Jung-gu, Seoul 100-715 (Korea, Republic of) [Department of Life Science, Dongguk University, 30 Pildong-ro 1-gil, Jung-gu, Seoul 100-715 (Korea, Republic of); Institute of Environmental Medicine for Green Chemistry, Dongguk University, 30 Pildong-ro 1-gil, Jung-gu, Seoul 100-715 (Korea, Republic of); Department of Pharmacology, Institute for Biomedical Science (IBMS), School of Medicine, Kyung Hee University, Seoul 130-701 (Korea, Republic of); Kim, Sang Uk [School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang 790-784 (Korea, Republic of) [School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang 790-784 (Korea, Republic of); Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang 790-784 (Korea, Republic of); Seo, Young Rok, E-mail: seoyr1@naver.com [Department of Life Science, Dongguk University, 30 Pildong-ro 1-gil, Jung-gu, Seoul 100-715 (Korea, Republic of); Institute of Environmental Medicine for Green Chemistry, Dongguk University, 30 Pildong-ro 1-gil, Jung-gu, Seoul 100-715 (Korea, Republic of); Department of Pharmacology, Institute for Biomedical Science (IBMS), School of Medicine, Kyung Hee University, Seoul 130-701 (Korea, Republic of)

    2013-05-03T23:59:59.000Z

    Highlights: ? Emerging critical role for Gadd45? in modulating BER activity. ? Identifying specific PCNA binding site on Gadd45? protein. ? Regulating APE1 activity through interaction between Gadd45? and PCNA. ? Suggesting potential role of Gadd45?–PCNA binding in pancreatic carcinogenesis. -- Abstract: The growth arrest and DNA damage inducible, alpha (Gadd45?) protein regulates DNA repair by interacting with proliferating cell nuclear antigen (PCNA). Our previous study suggested a potential role for Gadd45? in the base excision repair (BER) pathway by affecting apurinic/apyrimidinic endonuclease 1 (APE1) protein in addition to its accepted role in nucleotide excision repair (NER). Here, we investigated whether the interaction of Gadd45? with PCNA affects APE1 activity. To address this issue, we used a siRNA directed to Gadd45? and a form of Gadd45? with a mutation to the predicted site of PCNA binding. There was a reduction of APE1 activity in cells transfected with the Gadd45? siRNA. Furthermore, the interaction of Gadd45? with PCNA and APE1 was lower in cells transfected with mutant Gadd45? compared with cells transfected with wild-type Gadd45?. Indeed, we observed that the APE1 activity in the Gadd45?-interacting complex was significantly lower in cells that overexpress mutant Gadd45? compared with cells that overexpress wild-type Gadd45?. We conclude that the PCNA binding site on Gadd45? plays a critical role in modulating the interaction with PCNA and APE1, affecting BER activity. These results provide novel insights into the mechanisms by which BER activity is modulated, although the interaction of Gadd45? with APE1 needs to be clarified.

  6. Collector's problem Byron Schmuland

    E-Print Network [OSTI]

    Schmuland, Byron

    Collector's problem Byron Schmuland Department of Mathematical Sciences University of Alberta the mathematics of the collector's problem. For simplicity, let's assume that you buy cards one at a time, average doesn't mean typical. Some hockey card collectors will need to buy 1525 cards or so, but some

  7. A survey of repair practices for nuclear power plant containment metallic pressure boundaries

    SciTech Connect (OSTI)

    Oland, C.B.; Naus, D.J. [Oak Ridge National Lab., TN (United States)

    1998-05-01T23:59:59.000Z

    The Nuclear Regulatory Commission has initiated a program at the Oak Ridge National Laboratory to provide assistance in their assessment of the effects of potential degradation on the structural integrity and leaktightness of metal containment vessels and steel liners of concrete containments in nuclear power plants. One of the program objectives is to identify repair practices for restoring metallic containment pressure boundary components that have been damaged or degraded in service. This report presents issues associated with inservice condition assessments and continued service evaluations and identifies the rules and requirements for the repair and replacement of nonconforming containment pressure boundary components by welding or metal removal. Discussion topics include base and welding materials, welding procedure and performance qualifications, inspection techniques, testing methods, acceptance criteria, and documentation requirements necessary for making acceptable repairs and replacements so that the plant can be returned to a safe operating condition.

  8. Evaluation of bisphenol E cyanate ester for the resin-injection repair of advanced composites

    SciTech Connect (OSTI)

    Wilber Yaote Lio

    2009-12-19T23:59:59.000Z

    This thesis is a compilation of a general introduction and literature review that ties together the subsequent chapters which consist of two journal articles that have yet to be submitted for publication. The overall topic relates to the evaluation and application of a new class of cyanate ester resin with unique properties that lend it applicable to use as a resin for injection repair of high glass transition temperature polymer matrix composites. The first article (Chapter 2) details the evaluation and optimization of adhesive properties of this cyanate ester and alumina nanocomposites under different conditions. The second article (Chapter 3) describes the development and evaluation of an injection repair system for repairing delaminations in polymer matrix composites.

  9. Automatic coke oven heating control system at Burns Harbor for normal and repair operation

    SciTech Connect (OSTI)

    Battle, E.T.; Chen, K.L. [Bethlehem Steel Corp., Burns Harbor, IN (United States); [Bethlehem Steel Corp., PA (United States)

    1997-12-31T23:59:59.000Z

    An automatic heating control system for coke oven batteries was developed in 1985 for the Burns Harbor No. 1 battery and reported in the 1989 Ironmaking Conference Proceedings. The original system was designed to maintain a target coke temperature at a given production level under normal operating conditions. Since 1989, enhancements have been made to this control system so that it can also control the battery heating when the battery is under repair. The new control system has improved heating control capability because it adjusts the heat input to the battery in response to anticipated changes in the production schedule. During a recent repair of this 82 oven battery, the pushing schedule changed from 102 ovens/day to 88 ovens/day, then back to 102 ovens/day, then to 107 ovens/day. During this repair, the control system was able to maintain the coke temperature average standard deviation at 44 F, with a maximum 75 F.

  10. A review on axions and the strong CP problem

    SciTech Connect (OSTI)

    Kim, Jihn E. [Department of Physics and Astronomy, Seoul National University, Seoul 151-747 (Korea, Republic of)

    2010-02-10T23:59:59.000Z

    We review the recent developments on axion physics. Some new comments on the strong CP problem, the axion mass, and the simple energy loss mechanism of white dwarfs and related issues are included.

  11. When students can choose easy, medium, or hard homework problems

    E-Print Network [OSTI]

    Teodorescu, Raluca E.

    2012-01-01T23:59:59.000Z

    We investigate student-chosen, multi-level homework in our Integrated Learning Environment for Mechanics [1] built using the LON-CAPA [2] open-source learning system. Multi-level refers to problems categorized as easy, ...

  12. Faculty of Engineering Mechanical, Automotive and

    E-Print Network [OSTI]

    the aerospace industry. 2) Automotive Option - study topics such as vehicle dynamics, internal combustionFaculty of Engineering Mechanical, Automotive and Materials Engineering The field of Mechanical, Automotive and Materials Engineering offers a multi-faceted program where you tackle real-world problems

  13. The Guderley problem revisited

    SciTech Connect (OSTI)

    Ramsey, Scott D [Los Alamos National Laboratory; Kamm, James R [Los Alamos National Laboratory; Bolstad, John H [NON LANL

    2009-01-01T23:59:59.000Z

    The self-similar converging-diverging shock wave problem introduced by Guderley in 1942 has been the source of numerous investigations since its publication. In this paper, we review the simplifications and group invariance properties that lead to a self-similar formulation of this problem from the compressible flow equations for a polytropic gas. The complete solution to the self-similar problem reduces to two coupled nonlinear eigenvalue problems: the eigenvalue of the first is the so-called similarity exponent for the converging flow, and that of the second is a trajectory multiplier for the diverging regime. We provide a clear exposition concerning the reflected shock configuration. Additionally, we introduce a new approximation for the similarity exponent, which we compare with other estimates and numerically computed values. Lastly, we use the Guderley problem as the basis of a quantitative verification analysis of a cell-centered, finite volume, Eulerian compressible flow algorithm.

  14. Towards the cosmological constant problem

    E-Print Network [OSTI]

    Eun Kyung Park; Pyung Seong Kwon

    2014-12-15T23:59:59.000Z

    We apply a new self-tuning mechanism to the well-known Kachru-Kallosh-Linde-Trivedi (KKLT) model to address the cosmological constant problem. In this mechanism the cosmological constant $\\lambda$ contains a supersymmetry breaking term ${\\mathcal E}_{\\rm SB}$ besides the usual scalar potential ${\\mathcal V}_{\\rm scalar}$ of the $N=1$ supergravity, which is distinguished from the usual theories where $\\lambda$ is directly identified with ${\\mathcal V}_{\\rm scalar}$ alone. Also in this mechanism, whether $\\lambda$ vanishes or not is basically determined by the tensor structure of the scalar potential density, not by the zero or nonzero values of the scalar potential itself. As a result of this application we find that the natural scenario for the vanishing $\\lambda$ of the present universe is to take one of the AdS (rather than dS) vacua of KKLT as the background vacuum of our present universe. This AdS vacuum scenario does not suffer from the problematics of the dS vacua of KKLT. The background vacuum is stable both classically and quantum mechanically (no tunneling instabilities), and the value $\\lambda =0$ is also stable against quantum corrections because in this scenario the perturbative corrections of ${\\mathcal V}_{\\rm scalar}$ and quantum fluctuations $\\delta_Q {\\hat I}_{\\rm brane}^{(NS)} + \\delta_Q {\\hat I}_{\\rm brane}^{(R)}$ on the branes are all gauged away by an automatic cancelation between ${\\mathcal V}_{\\rm scalar} + \\delta_Q {\\hat I}_{\\rm brane}^{(NS)} + \\delta_Q {\\hat I}_{\\rm brane}^{(R)}$ and ${\\mathcal E}_{\\rm SB}$.

  15. Bosh repairs No. 3 blast furnace, Edgar Thomson Plant Mon Valley Works

    SciTech Connect (OSTI)

    Stoupis, M.G.

    1993-01-01T23:59:59.000Z

    The paper describes in detail the steps taken from quenching to dry out of the furnace to repair the bosh area of the No.3 blast furnace. Inspection of the area revealed that there was no brick anywhere in the bosh. Brick in the tuyere breast area had been peeled back to reveal the steel plate, and descaling revealed 14 pipes fully exposed. None were leaking, but one seemed badly deteriorated. Conventional repairs could not take place before the scheduled blow-in. Installation of coolers were instead tried.

  16. Remote reactor repair: GTA (gas tungsten Arc) weld cracking caused by entrapped helium

    SciTech Connect (OSTI)

    Kanne, W.R. Jr.

    1988-01-01T23:59:59.000Z

    A repair patch was welded to the wall of a nuclear reactor tank using remotely controlled thirty-foot long robot arms. Further repair was halted when gas tungsten arc (GTA) welds joining type 304L stainless steel patches to the 304 stainless steel wall developed toe cracks in the heat-affected zone (HAZ). The role of helium in cracking was investigated using material with entrapped helium from tritium decay. As a result of this investigation, and of an extensive array of diagnostic tests performed on reactor tank wall material, helium embrittlement was shown to be the cause of the toe cracks.

  17. Mitral Web -A New Concept for Mitral Valve Repair: Improved Engineering Design and In-Vitro Studies

    E-Print Network [OSTI]

    Pekkan, Kerem

    Mitral Web - A New Concept for Mitral Valve Repair: Improved Engineering Design and In of Biomedical Engineering, Georgia Institute of Technology, GA, USA Myxomatous mitral valve disease is currently reported that mitral valve repair is preferable to valve replace- ment, as it offers certain advantages

  18. Restoration and repair of 30-year old cooling towers at the Paducah Gaseous Diffusion Plant, Phase I. Draft 1

    SciTech Connect (OSTI)

    Shelton, M.F.

    1985-01-01T23:59:59.000Z

    Early in 1980, a comprehensive reliability study was made to ascertain the ability of the present 30-year old recirculating water system to meet the anticipated load demand through the year 2000. The findings and recommendations of this study were used as a guide to schedule uprating and repairs. This paper deals with the underground distribution system and cooling tower repairs.

  19. The Role of Nucleotide Excision Repair in Restoring Replication Following UV-Induced Damage in Escherichia coli

    E-Print Network [OSTI]

    Courcelle, Justin

    The Role of Nucleotide Excision Repair in Restoring Replication Following UV-Induced Damage DNA synthesis in the absence of nucleotide excision repair does not promote cell survivalA mutants....................... 26 Following low doses of UV irradiation cells lacking nucleotide excision

  20. Hot repair of ceramic burner on hot blast stoves at USS/Kobe`s {number_sign}3 blast furnace

    SciTech Connect (OSTI)

    Bernarding, T.F.; Chemorov, M.; Shimono, S.; Phillips, G.R.

    1997-12-31T23:59:59.000Z

    During the 1992 reline of the No. 3 blast furnace, three new stoves were constructed. The design of the stoves, equipped with internal ceramic burners, was for providing a hot blast temperature of 2,000 F at a wind rate of 140,000 SCFM. After 3 years the performance had deteriorated so the burners were cleaned. When a second cleaning did not improve the performance of No. 3 blast furnace, it was decided to repair the refractory while still hot. The paper describes the hot repair procedures, taking a stove off for repairs, maintenance heat up during repairs, two stove operation, stove commissioning, repair of a ceramic burner, and wet gas prevention.

  1. Sandia National Laboratories Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Problem Natural disasters such as Hurricane Katrina in New Orleans and the tsunami in Japan in 2011 create emergency situations that must be dealt with quickly and effectively in...

  2. Drinking Water Problems: Radionuclides 

    E-Print Network [OSTI]

    Lesikar, Bruce J.; Melton, Rebecca; Hare, Michael; Hopkins, Janie; Dozier, Monty

    2006-08-04T23:59:59.000Z

    Radionuclides in drinking water can cause serious health problems for people. This publication explains what the sources of radionuclides in water are, where high levels have been found in Texas, how they affect health and how to treat water...

  3. Avoiding Calving Problems

    E-Print Network [OSTI]

    Sprott, L. R.

    1998-03-12T23:59:59.000Z

    Calving difficulty, or dystocia, is influenced largely by genetics and the age of the dam. The main cause of calving problems is heavy birthweight. Solutions include selecting the right bull and mating it to properly developed heifers....

  4. NP-complete Problems and Physical Reality

    E-Print Network [OSTI]

    Scott Aaronson

    2005-02-21T23:59:59.000Z

    Can NP-complete problems be solved efficiently in the physical universe? I survey proposals including soap bubbles, protein folding, quantum computing, quantum advice, quantum adiabatic algorithms, quantum-mechanical nonlinearities, hidden variables, relativistic time dilation, analog computing, Malament-Hogarth spacetimes, quantum gravity, closed timelike curves, and "anthropic computing." The section on soap bubbles even includes some "experimental" results. While I do not believe that any of the proposals will let us solve NP-complete problems efficiently, I argue that by studying them, we can learn something not only about computation but also about physics.

  5. AKS systems and Lepage equivalent problems

    E-Print Network [OSTI]

    Santiago Capriotti

    2011-01-06T23:59:59.000Z

    The integrable systems known as "AKS systems" admit a natural formulation in terms of a Hamiltonian picture. The Lagrangian side of these systems are far less known; a version in these terms can be found in a work of Feher et al. The purpose of these notes in to provide a novel description of AKS systems in terms of a variational problem different from the usual in mechanics. Additionally, and using techniques borrowed from an article of M. Gotay, it was possible to build the Hamiltonian side of this variational problem, allowing us to establish the equivalence with the usual approach to these integrable systems.

  6. Analytical solutions to matrix diffusion problems

    SciTech Connect (OSTI)

    Kekäläinen, Pekka, E-mail: pekka.kekalainen@helsinki.fi [Laboratory of Radiochemistry, Department of Chemistry, P.O. Box 55, FIN-00014 University of Helsinki (Finland)

    2014-10-06T23:59:59.000Z

    We report an analytical method to solve in a few cases of practical interest the equations which have traditionally been proposed for the matrix diffusion problem. In matrix diffusion, elements dissolved in ground water can penetrate the porous rock surronuding the advective flow paths. In the context of radioactive waste repositories this phenomenon provides a mechanism by which the area of rock surface in contact with advecting elements is greatly enhanced, and can thus be an important delay mechanism. The cases solved are relevant for laboratory as well for in situ experiments. Solutions are given as integral representations well suited for easy numerical solution.

  7. Toward a State of Good Repair for Railroad Bridges through Structural Health Monitoring

    E-Print Network [OSTI]

    Bustamante, Fabián E.

    Toward a State of Good Repair for Railroad Bridges through Structural Health Monitoring NUTC of this research is to add a new tool to the asset management toolbox: structural health monitoring, particularly is Structural Health Monitoring (SHM)? SHM is process of intelligently collecting data from sensors on critical

  8. Multilayer sulfur-resistant composite metal membranes and methods of making and repairing the same

    DOE Patents [OSTI]

    Way, J. Douglas; Hatlevik, Oyvind

    2014-07-15T23:59:59.000Z

    The invention relates to thin, hydrogen-permeable, sulfur-resistant membranes formed from multi-layers of palladium or palladium-alloy coatings on porous, ceramic or metal supports, methods of making these membranes, methods of repairing layers of these membranes and devices that incorporate these membranes.

  9. Development/Plasticity/Repair Deletion of ERK2 Mitogen-Activated Protein Kinase

    E-Print Network [OSTI]

    Development/Plasticity/Repair Deletion of ERK2 Mitogen-Activated Protein Kinase Identifies Its Key University, Piscataway, New Jersey 08855-8082 The mitogen-activated protein (MAP) kinases ERK1 and ERK2-specific functions in vivo. We have examined the role of ERK2 in neural development by conditional inactivation

  10. Development/Plasticity/Repair The ERK2 Mitogen-Activated Protein Kinase Regulates the

    E-Print Network [OSTI]

    Development/Plasticity/Repair The ERK2 Mitogen-Activated Protein Kinase Regulates the Timing Oligodendrocytedevelopmentistightlycontrolledbyavarietyofextracellulargrowthanddifferentiationfactors.Themitogen-activated protein kinases (MAPKs), ERK1 and ERK2, are critical intracellular signaling (ERKs) are ubiquitously expressed, coordinately regulated, and highly similar, but Erk2 deletion in mice

  11. Development/Plasticity/Repair Phosphatidylinositol 3-Kinase Activates ERK in Primary

    E-Print Network [OSTI]

    Clapham, David E.

    Development/Plasticity/Repair Phosphatidylinositol 3-Kinase Activates ERK in Primary Sensory activation to inflammatory pain. We further investigated the correlationbetweenthePI3KandtheERK294002 and wortmannin, indicative of the activation of PI3K by both agents. ERK activation by capsaicin

  12. Development/Plasticity/Repair Disrupted ERK Signaling during Cortical Development Leads

    E-Print Network [OSTI]

    Development/Plasticity/Repair Disrupted ERK Signaling during Cortical Development Leads to Abnormal disorders arising from copy number variations in the ERK (extracellular signal-regulated kinase) MAP that these changes are due to ERK-dependent dysregulation of cyclin D1 and p27Kip1 , resulting in cell cycle

  13. Lazy Means Smart: Reducing Repair Bandwidth Costs in Erasure-coded Distributed Storage

    E-Print Network [OSTI]

    Alvisi, Lorenzo

    ,10)-encoded storage in this system results in hundreds of terabytes of daily recovery traffic through Top- Of an energy-conserving, storage-efficient, hybrid hadoop compute cluster. In Proceedings of the 2010Lazy Means Smart: Reducing Repair Bandwidth Costs in Erasure-coded Distributed Storage Mark

  14. FFaacciilliittiieess MMaannaaggeemmeenntt//EEnnvviirroonnmmeennttaall HHeeaalltthh && SSaaffeettyy Hazardous Work Area/Equipment Repair Form

    E-Print Network [OSTI]

    Mojzsis, Stephen J.

    Hazardous Work Area/Equipment Repair Form Form Instructions: Client is responsible for completing this form to assure that equipment and/or immediate work areas are not contaminated with any hazardous materials, tissue, etc.) Do Safety Hazards exist in the work area? N ___ Y ___ (Electrical, burn, or trip hazards

  15. Repair and Replacement projects help FM to honor its commitment to

    E-Print Network [OSTI]

    Gulliver, Robert

    of the University. Services provided fall into three major categories: preventive maintenance, routine repairs friendly power. Energy Management is continually recognized for the superior maintenance. · Maintenance (www.facm.umn. edu/services/maintenance.html) Maintenance Operations preserves the physical assets

  16. Home Maintenance and Repair Owning a home is a major responsibility.

    E-Print Network [OSTI]

    maintenance is conducted. Regular, preventive maintenance can pay off in peace of mind, utility cost savings, routine maintenance helps to prolong the life of the home and may prevent the need for major repairs of Benjamin Franklin, "An ounce of prevention is worth a pound of cure." Regular, routine maintenance enhances

  17. Investigation of Corrosion Damage and Repair System in a Concrete Jetty Structure

    E-Print Network [OSTI]

    Mobasher, Barzin

    Investigation of Corrosion Damage and Repair System in a Concrete Jetty Structure Farid Moradi of the deterioration was reinforcement corrosion, which initiated within few years after the completion of the jetty structure. The structure underwent major corrosion rehabilitation after 7 years of service. Despite the use

  18. Development/Plasticity/Repair The Bone Morphogenetic Protein Roof Plate Chemorepellent

    E-Print Network [OSTI]

    Butler, Samantha

    Development/Plasticity/Repair The Bone Morphogenetic Protein Roof Plate Chemorepellent Regulates, Toronto, Ontario, Canada M5G 1X8 Commissural spinal axons extend away from the roof plate (RP) in response to the dorsal midline and are generated by the bone morphogenetic proteins (BMPs) in the roof plate (RP) (Liem

  19. Development/Plasticity/Repair A Structural MRI Study of Human Brain Development from

    E-Print Network [OSTI]

    Utah, University of

    Development/Plasticity/Repair A Structural MRI Study of Human Brain Development from Birth to 2 Carolina, Chapel Hill, North Carolina 27599-7510 Brain development in the first 2 years after birth and schizophrenia. Knowledge regarding this period is currently quite limited. We studied structural brain

  20. Provably Repairing the ISO/IEC 9798 Standard for Entity Authentication

    E-Print Network [OSTI]

    Basin, David

    , or authentication of transmitted data [27,33]. The ISO (International Organization for Standardization) and IECProvably Repairing the ISO/IEC 9798 Standard for Entity Authentication David Basin, Cas Cremers the family of entity authentication protocols defined by the ISO/IEC 9798 standard and find numerous

  1. Provably Repairing the ISO/IEC 9798 Standard for Entity Authentication

    E-Print Network [OSTI]

    Basin, David

    (International Organization for Standardization) and IEC (Interna- tional Electrotechnical Commission) jointlyProvably Repairing the ISO/IEC 9798 Standard for Entity Authentication David Basin, Cas Cremers the family of entity authentication proto- cols defined by the ISO/IEC 9798 standard and find numerous

  2. Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction1

    E-Print Network [OSTI]

    Stuart, Jeffrey A.

    Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction1 of Biology, Brock University, St. Catharines, Ontario, Canada; and Gazi University, Faculty of Pharmacy in kidney mitochondria. 4. CR increases nuclear BER activity BER activity and the activities of proteins

  3. Development/Plasticity/Repair Dendritic Spine Dynamics Regulate the Long-Term Stability

    E-Print Network [OSTI]

    van Rossum, Mark

    Development/Plasticity/Repair Dendritic Spine Dynamics Regulate the Long-Term Stability of Synaptic Plasticity Cian O'Donnell,1,2 Matthew F. Nolan,3 and Mark C. W. van Rossum1 1Institute for Adaptive of Edinburgh, Edinburgh EH8 9XD, United Kingdom Long-term synaptic plasticity requires postsynaptic influx

  4. Development/Plasticity/Repair A Refractory Period for Rejuvenating GABAergic Synaptic

    E-Print Network [OSTI]

    Gruner, Daniel S.

    Development/Plasticity/Repair A Refractory Period for Rejuvenating GABAergic Synaptic Transmission and Ocular Dominance Plasticity with Dark Exposure Shiyong Huang,1* Yu Gu,2* Elizabeth M. Quinlan,2 Dark exposure initiated in adulthood reactivates robust ocular dominance plasticity in the visual

  5. Development/Plasticity/Repair Simultaneous NMDA-Dependent Long-Term Potentiation of

    E-Print Network [OSTI]

    Segal, Menahem

    Development/Plasticity/Repair Simultaneous NMDA-Dependent Long-Term Potentiation of EPSCs and Long activity-dependent long-term plasticity of neuronal networks is the interplay between excitatory, whereas a nitric oxide synthase inhibitor was ineffec- tive. Finally, network-induced plasticity

  6. Development/Plasticity/Repair Identification of Modulators of Hair Cell Regeneration in the

    E-Print Network [OSTI]

    Rubel, Edwin

    Development/Plasticity/Repair Identification of Modulators of Hair Cell Regeneration compounds that modulate hair cell regeneration in zebrafish. Of the 1680 compounds evaluated, we identified,aresyntheticglucocorticoidsthatpotentiatedhaircellnumbersduringregenerationandalsoinducedhair cell addition in the absence of damage. BrdU analysis confirmed that the extra hair cells arose from

  7. Development/Plasticity/Repair Hair Cell Replacement in Adult Mouse Utricles after

    E-Print Network [OSTI]

    Rubel, Edwin

    Development/Plasticity/Repair Hair Cell Replacement in Adult Mouse Utricles after Targeted Ablation of Hair Cells with Diphtheria Toxin Justin S. Golub,1 Ling Tong,1 Tot B. Ngyuen,1 Cliff R. Hume,1 Richard developed a transgenic mouse to permit conditional and selective ablation of hair cells in the adult mouse

  8. Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutS[beta

    SciTech Connect (OSTI)

    Tseng, Quincy; Orans, Jillian; Hast, Michael A.; Iyer, Ravi R.; Changela, Anita; Modrich, Paul L.; Beese, Lorena S. (Duke)

    2012-03-16T23:59:59.000Z

    MutS{beta} is a eukaryotic mismatch repair protein that preferentially targets extrahelical unpaired nucleotides and shares partial functional redundancy with MutS{alpha} (MSH2-MSH6). Although mismatch recognition by MutS{alpha} has been shown to involve a conserved Phe-X-Glu motif, little is known about the lesion-binding mechanism of MutS{beta}. Combined MSH3/MSH6 deficiency triggers a strong predisposition to cancer in mice and defects in msh2 and msh6 account for roughly half of hereditary nonpolyposis colorectal cancer mutations. These three MutS homologs are also believed to play a role in trinucleotide repeat instability, which is a hallmark of many neurodegenerative disorders. The baculovirus overexpression and purification of recombinant human MutS{beta} and three truncation mutants are presented here. Binding assays with heteroduplex DNA were carried out for biochemical characterization. Crystallization and preliminary X-ray diffraction analysis of the protein bound to a heteroduplex DNA substrate are also reported.

  9. The Sedov Test Problem

    SciTech Connect (OSTI)

    Fung, Jimmy [Los Alamos National Laboratory; Masser, Thomas [Los Alamos National Laboratory; Morgan, Nathaniel R. [Los Alamos National Laboratory

    2012-06-25T23:59:59.000Z

    The Sedov test is classically defined as a point blast problem. The Sedov problem has led us to advances in algorithms and in their understanding. Vorticity generation can be physical or numerical. Both play a role in Sedov calculations. The RAGE code (Eulerian) resolves the shock well, but produces vorticity. The source definition matters. For the FLAG code (Lagrange), CCH is superior to SGH by avoiding spurious vorticity generation. FLAG SGH currently has a number of options that improve results over traditional settings. Vorticity production, not shock capture, has driven the Sedov work. We are pursuing treatments with respect to the hydro discretization as well as to artificial viscosity.

  10. Repair limits for hot-section components of gas turbines

    SciTech Connect (OSTI)

    Mattheij, J.H.G.

    1998-07-01T23:59:59.000Z

    Gas turbine components are subjected to high mechanical and thermal stresses. In addition, the environment in which they operate is often corrosive. Under these conditions, only one group of materials can be used, i.e., superalloys. Superalloys are alloys of nickel or cobalt that are strengthened by both a large number and volume of alloying elements: tantalum, titanium, tungsten and chromium for carbide precipitation for high temperature strength. Aluminum and titanium form an intermetallic precipitation phase that can highly increase creep resistance. Boron and zirconium increase the grain boundary strength. Characteristic properties of superalloys are: high tensile strength, high creep strength, fair ductility, and good corrosion resistance. This combination of properties, which exists also at high temperature, is unique for superalloys and, in consequence, gas turbine hot-section components are uniquely made of superalloys.

  11. Drinking Water Problems: MTBE

    E-Print Network [OSTI]

    Dozier, Monty; Lesikar, Bruce J.

    2008-08-28T23:59:59.000Z

    Methyl tertiary-butyl ether, a gasoline additive commonly known as MTBE, can contaminate ground water and cause health problems for those exposed to it for a long time. However, filtering devices can remove this and other additives from well water...

  12. Linear Programming brewer's problem

    E-Print Network [OSTI]

    Sedgewick, Robert

    : Brewer's problem Small brewery produces ale and beer. · Production limited by scarce resources: corn, hops, barley malt. · Recipes for ale and beer require different proportions of resources. Brewer 160 1190 ale (1 barrel) 5 4 35 13 beer (1 barrel) 15 4 20 23 all ale (34 barrels) 179 136 1190 442 all

  13. Drinking Water Problems: Corrosion

    E-Print Network [OSTI]

    Drinking Water Problems: Corrosion Mark L. McFarland, Tony L. Provin, and Diane E. Boellstorff and fail. Corrosion can cause three types of damage: · The entire metal surface gradually thins and red (Fig. 1). · Deep pits appear that can penetrate pipe or tank walls. This type of corrosion may not add

  14. Problems in Engineering and

    E-Print Network [OSTI]

    Eagar, Thomas W.

    Problems in Engineering and Science Education Why Do We Have a Weakness in Materials Synthesis, Materials Science and Engineering in the 1990s: Maintaining Competitiveness in the Age of Materials science and engi- neering alone; it is symptomatic of the way we teach all science and engineering. We

  15. Regularizing Inverse Problems

    E-Print Network [OSTI]

    Wang, Fang

    2014-06-26T23:59:59.000Z

    (q) include ?q??(2@L^(2 ) )??q??(2@H^(1) ), |q|BV and |q|TV. However, each of these has its limitations. In this work, we develop a novel H^(s) seminorm regularization method and present numerical results for model problems. This method relies...

  16. Using Differential Adhesion to Control Self-Assembly and Self-Repair of Collections of Modular Mobile Robots 

    E-Print Network [OSTI]

    Ottery, Peter

    This thesis presents a novel distributed control method which allows a collection of independently mobile robotic units, with two or three dimensional movement, to self-assemble into self-repairing hierarchical structures. ...

  17. Simple Models of the Protein Folding Problem

    E-Print Network [OSTI]

    Chao Tang

    1999-12-26T23:59:59.000Z

    The protein folding problem has attracted an increasing attention from physicists. The problem has a flavor of statistical mechanics, but possesses the most common feature of most biological problems -- the profound effects of evolution. I will give an introduction to the problem, and then focus on some recent work concerning the so-called ``designability principle''. The designability of a structure is measured by the number of sequences that have that structure as their unique ground state. Structures differ drastically in terms of their designability; highly designable structures emerge with a number of associated sequences much larger than the average. These highly designable structures 1) possess ``proteinlike'' secondary structures and motifs, 2) are thermodynamically more stable, and 3) fold faster than other structures. These results suggest that protein structures are selected in nature because they are readily designed and stable against mutations, and that such selection simultaneously leads to thermodynamic stability and foldability. According to this picture, a key to the protein folding problem is to understand the emergence and the properties of the highly designable structures.

  18. Repair of localized defects in multilayer-coated reticle blanks for extreme ultraviolet lithography

    DOE Patents [OSTI]

    Stearns, Daniel G. (Los Altos, CA); Sweeney, Donald W. (San Ramon, CA); Mirkarimi, Paul B. (Sunol, CA)

    2004-11-23T23:59:59.000Z

    A method is provided for repairing defects in a multilayer coating layered onto a reticle blank used in an extreme ultraviolet lithography (EUVL) system. Using high lateral spatial resolution, energy is deposited in the multilayer coating in the vicinity of the defect. This can be accomplished using a focused electron beam, focused ion beam or a focused electromagnetic radiation. The absorbed energy will cause a structural modification of the film, producing a localized change in the film thickness. The change in film thickness can be controlled with sub-nanometer accuracy by adjusting the energy dose. The lateral spatial resolution of the thickness modification is controlled by the localization of the energy deposition. The film thickness is adjusted locally to correct the perturbation of the reflected field. For example, when the structural modification is a localized film contraction, the repair of a defect consists of flattening a mound or spreading out the sides of a depression.

  19. Nondestructive evaluation and characterization of damage and repair to continuous-fiber ceramic composite panels.

    SciTech Connect (OSTI)

    Sun, J. G.; Petrak, D. R.; Pillai, T. A. K.; Deemer, C.; Ellingson, W. A.

    1998-04-01T23:59:59.000Z

    Continuous fiber ceramic matrix composites are currently being developed for a variety of high-temperature applications. Because of the high costs of making these components, minor damage incurred during manufacturing or operation must be rewired in order to extend the life of the components. In this study, five ceramic-grade Nicalon{trademark} fiber/SiNC-matrix composite panels were intentionally damaged with a pendulum-type impactor during an impact test. The damaged panels were then repaired at Dow Corning Corporation. Three nondestructive evaluation (NDE) methods were used to study the characteristics of the panels after the damage and again after the panels were repaired. The NDE methods were X-ray radiography, infrared thermal imaging, and air-coupled ultrasound. The results showed that the impact test induced various types of damage in the panels. The NDE data that were obtained by the three NDE methods were correlated with each other.

  20. Weld Repair of a Stamped Pressure Vessel in a Radiologically Controlled Zone

    SciTech Connect (OSTI)

    Cannell, Gary L. [Fluor Enterprises, Inc.; Huth, Ralph J. [CH2MHill Plateau Remediation Company; Hallum, Randall T. [Fluor Government Group

    2013-08-26T23:59:59.000Z

    In September 2012 an ASME B&PVC Section VIII stamped pressure vessel located at the DOE Hanford Site Effluent Treatment Facility (ETF) developed a through-wall leak. The vessel, a steam/brine heat exchanger, operated in a radiologically controlled zone (by the CH2MHill PRC or CHPRC), had been in service for approximately 17 years. The heat exchanger is part of a single train evaporator process and its failure caused the entire system to be shut down, significantly impacting facility operations. This paper describes the activities associated with failure characterization, technical decision making/planning for repair by welding, logistical challenges associated with performing work in a radiologically controlled zone, performing the repair, and administrative considerations related to ASME code requirements.

  1. Subterranean barriers, methods, and apparatuses for forming, inspecting, selectively heating, and repairing same

    DOE Patents [OSTI]

    Nickelson, Reva A. (Shelley, ID); Sloan, Paul A. (Rigby, ID); Richardson, John G. (Idaho Falls, ID); Walsh, Stephanie (Idaho Falls, ID); Kostelnik, Kevin M. (Idaho, ID)

    2009-04-07T23:59:59.000Z

    A subterranean barrier and method for forming same are disclosed, the barrier including a plurality of casing strings wherein at least one casing string of the plurality of casing strings may be affixed to at least another adjacent casing string of the plurality of casing strings through at least one weld, at least one adhesive joint, or both. A method and system for nondestructively inspecting a subterranean barrier is disclosed. For instance, a radiographic signal may be emitted from within a casing string toward an adjacent casing string and the radiographic signal may be detected from within the adjacent casing string. A method of repairing a barrier including removing at least a portion of a casing string and welding a repair element within the casing string is disclosed. A method of selectively heating at least one casing string forming at least a portion of a subterranean barrier is disclosed.

  2. Template strand scrunching during DNA gap repair synthesis by human polymerase [lamda

    SciTech Connect (OSTI)

    Garcia-Diaz, Miguel; Bebenek, Katarzyna; Larrea, Andres A.; Havener, Jody M.; Perera, Lalith; Krahn, Joseph M.; Pedersen, Lars C.; Ramsden, Dale A.; Kunkel, Thomas A.; (NIH); (UNC)

    2009-09-25T23:59:59.000Z

    Family X polymerases such as DNA polymerase {lambda}(Pol {lambda}) are well suited for filling short gaps during DNA repair because they simultaneously bind both the 5{prime} and 3{prime} ends of short gaps. DNA binding and gap filling are well characterized for 1-nucleotide (nt) gaps, but the location of yet-to-be-copied template nucleotides in longer gaps is unknown. Here we present crystal structures revealing that, when bound to a 2-nt gap, Pol {lambda} scrunches the template strand and binds the additional uncopied template base in an extrahelical position within a binding pocket that comprises three conserved amino acids. Replacing these amino acids with alanine results in less processive gap filling and less efficient NHEJ when 2-nt gaps are involved. Thus, akin to scrunching by RNA polymerase during transcription initiation, scrunching occurs during gap filling DNA synthesis associated with DNA repair.

  3. Strange Bedfellows: Quantum Mechanics and Data Mining

    E-Print Network [OSTI]

    Marvin Weinstein

    2009-11-03T23:59:59.000Z

    Last year, in 2008, I gave a talk titled {\\it Quantum Calisthenics}. This year I am going to tell you about how the work I described then has spun off into a most unlikely direction. What I am going to talk about is how one maps the problem of finding clusters in a given data set into a problem in quantum mechanics. I will then use the tricks I described to let quantum evolution lets the clusters come together on their own.

  4. Heavy Mobile Equipment Mechanic (One Mechanic Shop)

    Broader source: Energy.gov [DOE]

    The position is a Heavy Mobile Equipment Mechanic (One Mechanic Shop) located in Kent, Washington, and will be responsible for the safe and efficient operation of a field garage performing...

  5. Declarative Problem Solving through Abduction

    E-Print Network [OSTI]

    Moraitis, Pavlos

    1 Declarative Problem Solving through Abduction Antonis C. Kakas Department of Computer Science PROBLEM SOLVING through Logical Representations (or models) of problems and the use of ABDUCTIVE REASONING · Acquire expertise in Declarative Problem Solving using the representation framework of ABDUCTIVE LOGIC

  6. "You Can Do It" Basic Home Repair Using Hand and Power Tools

    E-Print Network [OSTI]

    1 "You Can Do It" Basic Home Repair Using Hand and Power Tools by Janie L. Harris Extension Housing guard housing. Place the tool rest 1/8 inch from the wheel on bench-mounted units. Before starting://www.cdc.gov/nasd/docs/ University of Denver, Risk Management http://www.du.edu/risk/Tool_Safety.html #12;2 "You Can Do It" Basic

  7. The strengthening and repair of underground structures: A new approach to the management of nuclear waste

    SciTech Connect (OSTI)

    Colgate, S.A.

    1991-01-01T23:59:59.000Z

    This paper presents three closely related ideas and technologies: (1) The secure, repairable, long time confinement of nuclear radioactive waste underground by a large surrounding region of compressive overstress; (2) The inherent tectonic weakness and vulnerability of the normal underground environment and its modification by overstress; (3) The process of creating overstress by the sequential periodic high pressure injection of a finite gel strength rapid setting grout. 12 refs., 6 figs.

  8. Note: A Graph-Theoretical Approach to Level of Repair Analysis

    E-Print Network [OSTI]

    2004-08-29T23:59:59.000Z

    Aug 29, 2004 ... cilities to minimize overall life-cycle costs. ... decisions, LORA seeks to determine an optimal provision of repair and maintenance ... Their heuristic is based on a relaxation of LORA into a pair of ... R2 is a consequence of R1 and a policy of .... from the fact that one can find a minimum cut in N(B) in time O(n2.

  9. Development program to certify composite doubler repair technique for commercial aircraft

    SciTech Connect (OSTI)

    Roach, D.P.

    1997-07-01T23:59:59.000Z

    Commercial airframes exceeding 20 service years often develop crack and corrosion flaws. Bonded composite doublers offer a cost effective method to safely extend aircraft lives. The Federal Aircraft Authority (FAA) has completed a project to introduce composite doubler repair technology to the commercial aircraft industry. Instead of riveting steel or aluminum plates for repair, a single composite doubler may be bonded to the damaged structure. Adhesive bonding eliminates stress concentrations caused by fastener holes. Composites are readily formed into complex shapes for repairing irregular components. Also, composite doublers can be tailored to meet specific anisotropy needs, eliminating structural stiffening in directions other than those required. Other advantages include corrosion resistance, a high strength-to-weight ratio, and potential time savings in installation. One phase of this study developed general methodologies and test programs to ensure proper performance of the technique. A second phase focused on reinforcement of an L-1011 door frame, and encompassed all lifetime tasks such as design, analysis, installation, and nondestructive inspection. This paper overviews the project and details the activities conducted to gain FAA approval for composite doubler use. Structural tests evaluated the damage tolerance and fatigue performance of composite doublers while finite element models were generated to study doubler design issues. Nondestructive inspection procedures were developed and validated using full-scale test articles. Installation dry-runs demonstrated the viability of applying composite doublers in hangar environments. The project`s documentation package was used to support installation of a Boron-Epoxy composite repair on a Delta Air Lines L-1011 aircraft. A second product of the results is a Lockheed Service Bulletin which allows the door corner composite doubler to be installed on all L-1011 aircraft. 9 refs., 10 figs., 2 tabs.

  10. Lethal Hemorrhage Caused by Aortoesophageal Fistula Secondary to Stent-Graft Repair of the Thoracic Aorta

    SciTech Connect (OSTI)

    Sager, Hendrik B., E-mail: hendrik.sager@uk-sh.de [Universitaet zu Luebeck, Medizinische Klinik II (Germany); Wellhoener, Peter [Universitaet zu Luebeck, Medizinische Klinik I (Germany); Wermelt, Johanna A. [Klinikum Neustadt, Klinik fuer Innere Medizin (Germany); Schunkert, Heribert; Kurowski, Volkhard [Universitaet zu Luebeck, Medizinische Klinik II (Germany)

    2011-02-15T23:59:59.000Z

    Aortoesophageal fistula (AEF) is a rare but life-threatening complication after endovascular or surgical aortic repair. Here we report a patient with AEF secondary to aortic stent-placement 2 years earlier who presented with hematemesis and died from hemorrhagic shock. By means of this case and the literature, we highlight potential bleeding sources in such a scenario because this is of crucial importance for the management strategy.

  11. REPAIR OF A DAMAGED PART ON HYDRAULIC TRACT KAPLAN TURBINE WITH "LIQUID METAL"

    E-Print Network [OSTI]

    Fuad ?atovi?; Prof Emeritus; Edin Džiho Msc; Mostar Bih; Mustafa Šehi?; Hydroelectric Power Plant Neretva; Jablanica Bih

    During 2011 on unit no.2 reparation work was carried out aimed at fault removal on Kaplan turbine impeller, while extending the lifespan of the entire installed equipment. The overhaul included all vital parts, replacement of all gasket compresses, machine processing to achieve the required tolerances, NDT equipment control according to "Quality Control Plan", repairing equipment, etc. This paper describes the recovery of defects on the blades of the guide vanes using epoxy masses.

  12. Endovascular Repair of a Pseudoaneurysm of the Abdominal Aorta Secondary to Translumbar Aortography

    SciTech Connect (OSTI)

    Mir, Naheed; Nunzio, Mario De; Pollock, John G [Derbyshire Royal Infirmary, Department of Clinical Radiology (United Kingdom)], E-mail: JG.Pollock@derbyhospitals.nhs.uk

    2006-12-15T23:59:59.000Z

    This report describes an incidental finding of a pseudoaneurysm of the abdominal aorta on a computed tomography (CT) renal angiogram during investigation of chronic renal failure in a 73-year-old man. The patient had undergone a translumbar aortogram 20 years previously. An increase in the size of the aneurysm by 7 mm over 6 months prompted treatment and the aneurysm underwent successful endovascular repair with a custom-made stent-graft.

  13. The DNA Single-Strand Break Repair Machinery Facilitates CAF-1-Mediated Histone Deposition at Oxidative DNA Strand Breaks

    E-Print Network [OSTI]

    Arman Nabatiyan; Zhihong Zeng; Keith W. Caldecott

    2012-02-01T23:59:59.000Z

    Oxidative DNA single strand breaks arise continuously in cells and defects in their repair have been implicated in neurological disease. While much progress has been made in understanding how chromosomal single strand breaks are repaired little is known about the changes chromatin structure that accompany this process. Here, we show that nascent recombinant histone H3.1 protein accumulates and is deposited into chromatin at sites of DNA strand breakage in quiescent human cells following oxidative stress, and that core components of the single-strand break repair machinery are required for this process. We show that the SSBR sensor and scaffold proteins poly (ADP-ribose) polymerase and XRCC1 facilitate accumulation of chromatin assembly factor-1 (CAF-1) at sites of oxidative DNA strand breakage, which in turn mediates the deposition of Histone H3.1. We also demonstrate that depletion of CAF-1 slows global rates of DNA strand break repair in quiescent cells following oxidative stress, demonstrating that single-strand break repair and histone deposition are tightly coordinated processes. These data describe a novel role for the DNA singlestrand break repair machinery and implicate histone turnover as a core component of the cellular response of quiescent cells to oxidative damage.

  14. Plasma transferred arc repair welding of the nickel-base superalloy IN-738LC

    SciTech Connect (OSTI)

    Su, C.Y.; Chou, C.P. [National Chiao Tung Univ., Hsinchu (Taiwan, Province of China). Dept. of Mechanical Engineering; Wu, B.C.; Lih, W.C. [Industrial Technology Research Inst., Hsinchu (Taiwan, Province of China). Materials Research Labs.

    1997-10-01T23:59:59.000Z

    Plasma transferred arc welding (PTA) has been considered a promising process to restore worn areas of land-based gas turbine blades and vanes. The objective of this investigation was to study the effect of PTA welding on the repairing of IN-738LC superalloy components. Tensile tests were conducted on specimens welded with various combinations of parameters. Room temperature, 760 C, and 980 C were selected as tensile test temperatures. High-temperature phase transformed, during solidification, were identified by differential thermal analysis (DTA). The weld-pool shapes and microstructures of welded specimens prepared by various welding parameters were evaluated by optical metallography (OM), a scanning electron microscope (SEM) equipped with energy dispersive x-ray spectrometer (EDS), and microhardness testing. Results of this study showed that PTA welded specimens exhibited 96% nominal tensile strength of IN-738LC base materials. Specimen failure was observed predominantly in the base materials instead of in the heat-affected zone (HAZ) for gas tungsten arc weld (GTAW) repair weldments. IN-738LC is considered susceptible to weld cracking during fusion welding; however, using a low-input repair welding process (PTA), cracking susceptibility could be minimized by the optimized welding parameters.

  15. Quantum mechanism helps agents combat "bad" social choice rules

    E-Print Network [OSTI]

    Haoyang Wu

    2011-04-22T23:59:59.000Z

    Quantum strategies have been successfully applied to game theory for years. However, as a reverse problem of game theory, the theory of mechanism design is ignored by physicists. In this paper, the theory of mechanism design is generalized to a quantum domain. The main result is that by virtue of a quantum mechanism, agents who satisfy a certain condition can combat "bad" social choice rules instead of being restricted by the traditional mechanism design theory.

  16. Mechanical & Industrial Engineering

    E-Print Network [OSTI]

    Mountziaris, T. J.

    Mechanical & Industrial Engineering 1 Welcome MIE Industrial Advisory Board October 15, 2010 #12;Mechanical & Industrial Engineering 2 MIE Dorothy Adams Undergraduate/Graduate Secretary David Schmidt Associate Professor & Graduate Program Director #12;Mechanical & Industrial Engineering 3 MIE James Rinderle

  17. Mechanical Engineering & Thermal Group

    E-Print Network [OSTI]

    Mojzsis, Stephen J.

    Mechanical Engineering & Thermal Group The Mechanical Engineering (ME) & Thermal Group at LASP has · STOP (Structural, Thermal, and Optical Performance) analyses of optical systems Thermal engineers lead evolved with the complexity of instrument design demands, LASP mechanical engineers develop advanced

  18. Mechanical engineering Department Seminar

    E-Print Network [OSTI]

    and the Department of Mechanical Engineering Tufts University Retooling Our Energy Ecosystem: challengesMechanical engineering Department Seminar Robert J. Hannemann The Gordon Institute and Chair of the Tufts Department of Mechanical Engineering. His technical and academic interests

  19. Drinking Water Problems: Lead

    E-Print Network [OSTI]

    Dozier, Monty; McFarland, Mark L.

    2004-02-20T23:59:59.000Z

    A lmost everyone knows that lead-based paint caused serious health problems (especially in children) before it was banned. But not everyone is aware that people can ingest lead from other sources such as contaminat- ed food and drinking water... sources of lead con- tamination. But if your water comes from a private well, it might contain enough lead to warrant action. How does lead affect health? Lead can be absorbed through the digestive tract, the lungs and the skin. It accumulates in the body...

  20. An inexact labeling problem

    E-Print Network [OSTI]

    Murray, Margaret Shuey

    1984-01-01T23:59:59.000Z

    of prototype and candidate objects - . 1'7 3 ~ Tree showing possible unit-label assignments for the example of Figut'e 2 (p. 17) 4. Candidate and prototype objects 5. A 3x3 pixel window . . . ~ 6. S, r parameterization of a line 20 30 36 38 7. A... with the matching problem. Haralick and Shapiro [5] deal with a set of units, (u(, ~ . . . u }, and a set of labels, L (II, . . . , I 1 . For any n units ~ \\ qp (ul, . ~ . , u , n labels from L, 11, . . . , 1 ), can be selected and called a labeling of (ul...

  1. Euclid Known Problems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) Environmental Assessments (EA) /Email Announcements Archive EmailKnown Problems Known

  2. Mechanical & Aerospace Engineering

    E-Print Network [OSTI]

    Mechanical & Aerospace Engineering It is a new beginning for innovative fundamental and applied and consolidation of bulk nanocrystalline materials using mechanical alloying, the alloy development and synthesis

  3. The Primordial Lithium Problem

    E-Print Network [OSTI]

    Brian D. Fields

    2012-03-15T23:59:59.000Z

    Big-bang nucleosynthesis (BBN) theory, together with the precise WMAP cosmic baryon density, makes tight predictions for the abundances of the lightest elements. Deuterium and 4He measurements agree well with expectations, but 7Li observations lie a factor 3-4 below the BBN+WMAP prediction. This 4-5\\sigma\\ mismatch constitutes the cosmic "lithium problem," with disparate solutions possible. (1) Astrophysical systematics in the observations could exist but are increasingly constrained. (2) Nuclear physics experiments provide a wealth of well-measured cross-section data, but 7Be destruction could be enhanced by unknown or poorly-measured resonances, such as 7Be + 3He -> 10C^* -> p + 9B. (3) Physics beyond the Standard Model can alter the 7Li abundance, though D and 4He must remain unperturbed; we discuss such scenarios, highlighting decaying Supersymmetric particles and time-varying fundamental constants. Present and planned experiments could reveal which (if any) of these is the solution to the problem.

  4. Super problems for supercomputers

    SciTech Connect (OSTI)

    Peterson, I.

    1984-01-01T23:59:59.000Z

    This article discusses the ways in which simulations performed on high-speed computers combined with graphics are replacing experiments. Supercomputers ranging from the large, general-purpose Cray-1 and the CYBER 205 to machines designed for a specific type of calculation, are becoming essential research tools in many fields of science and engineering. Topics considered include crystal growth, aerodynamic design, molecular seismology, computer graphics, membrane design, quantum mechanical calculations, Soviet ''nuclear winter'' maps (modeling climate in a post-nuclear-war environment), and estimating nuclear forest fires. It is pointed out that the $15 million required to buy and support one supercomputer has limited its use in industry and universities.

  5. Thermodynamic integration from classical to quantum mechanics

    SciTech Connect (OSTI)

    Habershon, Scott [Centre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS (United Kingdom); Manolopoulos, David E. [Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QZ (United Kingdom)

    2011-12-14T23:59:59.000Z

    We present a new method for calculating quantum mechanical corrections to classical free energies, based on thermodynamic integration from classical to quantum mechanics. In contrast to previous methods, our method is numerically stable even in the presence of strong quantum delocalization. We first illustrate the method and its relationship to a well-established method with an analysis of a one-dimensional harmonic oscillator. We then show that our method can be used to calculate the quantum mechanical contributions to the free energies of ice and water for a flexible water model, a problem for which the established method is unstable.

  6. Improved Student Performance In Electricity And Magnetism Following Prior MAPS Instruction In Mechanics

    E-Print Network [OSTI]

    Rayyan, Saif

    We examine the performance of a group of students in Introductory Electricity and Magnetism following a ReView course in Introductory Mechanics focusing on problem solving employing the Modeling Applied to Problem Solving ...

  7. The continuum and wave mechanics

    E-Print Network [OSTI]

    Collins, Royal Eugene

    1954-01-01T23:59:59.000Z

    in the realm of our actual experience we find it possi? ble to define operational procedures for observing and 4 , and we A find that these procedures always yield values of ?f and "t . Further? more we always find that the observed values of the position... in our analysis of Classical Mechanics, therefore we now consider the following problem. If we consider w quantities iT HE M gnx DHqMyco and p? quantities-[ yO 4. to be defined by operations can we require that a function yA ? t j exists...

  8. Modeling applied to problem solving

    E-Print Network [OSTI]

    Pawl, Andrew

    We describe a modeling approach to help students learn expert problem solving. Models are used to present and hierarchically organize the syllabus content and apply it to problem solving, but students do not develop and ...

  9. The optimization problem Genetic Algorithm

    E-Print Network [OSTI]

    Giménez, Domingo

    The optimization problem Genetic Algorithm Particle Swarm Optimization Experimental results for time-power optimization META, October 27-31, 2014 1 / 25 #12;The optimization problem Genetic Algorithm Particle Swarm Optimization Experimental results Conclusions Time and energy optimization Traditionally

  10. Combined Quantum Mechanical and Molecular Mechanics Studies of...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mechanical and Molecular Mechanics Studies of the Electron-Transfer Reactions Involving Carbon Tetrachloride in Combined Quantum Mechanical and Molecular Mechanics Studies of the...

  11. 2005 Pearson Education South Asia Pte Ltd Applied Fluid Mechanics

    E-Print Network [OSTI]

    Leu, Tzong-Shyng "Jeremy"

    Education South Asia Pte Ltd Applied Fluid Mechanics 17.Drag and Lift 18.Fans, Blowers, Compressors the relationships between specific weight, specific gravity, and density, and solve problems using

  12. 2005 Pearson Education South Asia Pte Ltd Applied Fluid Mechanics

    E-Print Network [OSTI]

    Leu, Tzong-Shyng "Jeremy"

    Education South Asia Pte Ltd Applied Fluid Mechanics 17.Drag and Lift 18.Fans, Blowers, Compressors equation to a variety of practical problems. · Compute the power added to a fluid by pumps. #12;3 7

  13. 2005 Pearson Education South Asia Pte Ltd Applied Fluid Mechanics

    E-Print Network [OSTI]

    Leu, Tzong-Shyng "Jeremy"

    Education South Asia Pte Ltd Applied Fluid Mechanics 17.Drag and Lift 18.Fans, Blowers, Compressors Pearson Education South Asia Pte Ltd Example 9.1 In Example Problem 8.1 we found that the Reynolds number

  14. The mechanical behavior of heavily overconsolidated resedimented Boston Blue Clay

    E-Print Network [OSTI]

    Vargas Bustamante, Albalyra Geraldine

    2013-01-01T23:59:59.000Z

    Geotechnical engineers encounter some of the most challenging problems in heavily overconsolidated soils. Clays under this condition originated in nature or man-made construction. This thesis investigates the mechanical ...

  15. Proposal to negotiate two contracts, without competitive tendering, for the supply and the repair of compressors for the LHC 18 kW helium refrigeration plants

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    Proposal to negotiate two contracts, without competitive tendering, for the supply and the repair of compressors for the LHC 18 kW helium refrigeration plants

  16. Mechanical engineering Department Seminar

    E-Print Network [OSTI]

    Lin, Xi

    Mechanical engineering Department Seminar Ju Li Professor MIT Electrochemical-mechanical actions computational and experimental research on mechanical properties of materials, and energy storage and conversion Refreshments served at 10:45 AM The creation of a nanoscale electrochemical and mechanical testing platform

  17. The prediction problem Empirical studies

    E-Print Network [OSTI]

    McCullagh, Peter

    The prediction problem Empirical studies Details and summary Conditional prediction intervals 2009 Peter McCullagh, V. Vovk, I. Nouretdinov, D. Devetyarov and A. Gammerman #12;The prediction problem Empirical studies Details and summary Outline 1 The prediction problem Linear regression model

  18. DNA Repair Biomarkers Predict Response to Neoadjuvant Chemoradiotherapy in Esophageal Cancer

    SciTech Connect (OSTI)

    Alexander, Brian M., E-mail: bmalexander@lroc.harvard.edu [Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (United States); Wang Xiaozhe [On-Q-ity, Inc., Waltham, Massachusetts (United States); Niemierko, Andrzej [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States); Weaver, David T. [On-Q-ity, Inc., Waltham, Massachusetts (United States); Mak, Raymond H. [Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (United States); Roof, Kevin S. [Southeast Radiation Oncology, Charlotte, North Carolina (United States); Fidias, Panagiotis [Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts (United States); Wain, John [Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts (United States); Choi, Noah C. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts (United States)

    2012-05-01T23:59:59.000Z

    Purpose: The addition of neoadjuvant chemoradiotherapy prior to surgical resection for esophageal cancer has improved clinical outcomes in some trials. Pathologic complete response (pCR) following neoadjuvant therapy is associated with better clinical outcome in these patients, but only 22% to 40% of patients achieve pCR. Because both chemotherapy and radiotherapy act by inducing DNA damage, we analyzed proteins selected from multiple DNA repair pathways, using quantitative immunohistochemistry coupled with a digital pathology platform, as possible biomarkers of treatment response and clinical outcome. Methods and Materials: We identified 79 patients diagnosed with esophageal cancer between October 1994 and September 2002, with biopsy tissue available, who underwent neoadjuvant chemoradiotherapy prior to surgery at the Massachusetts General Hospital and used their archived, formalin-fixed, paraffin-embedded biopsy samples to create tissue microarrays (TMA). TMA sections were stained using antibodies against proteins in various DNA repair pathways including XPF, FANCD2, PAR, MLH1, PARP1, and phosphorylated MAPKAP kinase 2 (pMK2). Stained TMA slides were evaluated using machine-based image analysis, and scoring incorporated both the intensity and the quantity of positive tumor nuclei. Biomarker scores and clinical data were assessed for correlations with clinical outcome. Results: Higher scores for MLH1 (p = 0.018) and lower scores for FANCD2 (p = 0.037) were associated with pathologic response to neoadjuvant chemoradiation on multivariable analysis. Staining of MLH1, PARP1, XPF, and PAR was associated with recurrence-free survival, and staining of PARP1 and FANCD2 was associated with overall survival on multivariable analysis. Conclusions: DNA repair proteins analyzed by immunohistochemistry may be useful as predictive markers for response to neoadjuvant chemoradiotherapy in patients with esophageal cancer. These results are hypothesis generating and need confirmation in an independent data set.

  19. JAG Tearing Technique with Radiofrequency Guide Wire for Aortic Fenestration in Thoracic Endovascular Aneurysm Repair

    SciTech Connect (OSTI)

    Ricci, Carmelo [Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte, Radiologia Interventistica (Italy); Ceccherini, Claudio, E-mail: claudiocec@hotmail.it; Leonini, Sara [Radiologia Universitaria, Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte (Italy); Cini, Marco; Vigni, Francesco [Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte, Radiologia Interventistica (Italy); Neri, Eugenio; Tucci, Enrico; Benvenuti, Antonio; Tommasino, Giulio; Sassi, Carlo [Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte, Chirurgia dell'Aorta Toracica (Italy)

    2012-02-15T23:59:59.000Z

    An innovative approach, the JAG tearing technique, was performed during thoracic endovascular aneurysm repair in a patient with previous surgical replacement of the ascending aorta with a residual uncomplicated type B aortic dissection who developed an aneurysm of the descending thoracic aorta with its lumen divided in two parts by an intimal flap. The proximal landing zone was suitable to place a thoracic stent graft. The distal landing zone was created by cutting the intimal flap in the distal third of the descending thoracic aorta with a radiofrequency guide wire and intravascular ultrasound catheter.

  20. Endovascular Stent-Graft Repair as a Late Secondary Procedure After Previous Aortic Grafts

    SciTech Connect (OSTI)

    Matsagas, Miltiadis I. [School of Medicine, University of Ioannina, Department of Surgery - Vascular Surgery Unit (Greece)], E-mail: mimats@cc.uoi.gr; Anagnostopoulos, Constantine E. [School of Medicine, University of Ioannina, Department of Cardiothoracic Surgery (Greece); Papakostas, John C. [School of Medicine, University of Ioannina, Department of Surgery - Vascular Surgery Unit (Greece); DeRose, Joseph J. [St. Luke's-Roosevelt Hospital, Columbia University, Department of Cardiothoracic Surgery (United States); Siminelakis, Stavros [School of Medicine, University of Ioannina, Department of Cardiothoracic Surgery (Greece); Katsouras, Christos S. [School of Medicine, University of Ioannina, Department of Cardiology (Greece); Toumpoulis, Ioannis K.; Drossos, George E. [School of Medicine, University of Ioannina, Department of Cardiothoracic Surgery (Greece); Michalis, Lampros K. [School of Medicine, University of Ioannina, Department of Cardiology (Greece)

    2006-08-15T23:59:59.000Z

    Thoracic and abdominal aortic endovascular procedures as alternatives to aortic reoperations were studied in three different cases. An anastomotic aneurysm after previous thoracic aortic graft for coarctation, a second-stage elephant trunk repair (descending thoracic aortic aneurysm), and a secondary aneurysm proximal to a previous abdominal aortic graft were successfully treated with endovascular stent-grafts. During the follow-up period no lethal events or major aortic or graft-related complications were observed, except a type II endoleak in the anastomotic aortic aneurysm case. An endovascular stent-graft can be safely deployed into a previously implanted vascular graft, avoiding repeat surgery.

  1. Large Spectral Library Problem

    SciTech Connect (OSTI)

    Chilton, Lawrence K.; Walsh, Stephen J.

    2008-10-03T23:59:59.000Z

    Hyperspectral imaging produces a spectrum or vector at each image pixel. These spectra can be used to identify materials present in the image. In some cases, spectral libraries representing atmospheric chemicals or ground materials are available. The challenge is to determine if any of the library chemicals or materials exist in the hyperspectral image. The number of spectra in these libraries can be very large, far exceeding the number of spectral channels collected in the Żeld. Suppose an image pixel contains a mixture of p spectra from the library. Is it possible to uniquely identify these p spectra? We address this question in this paper and refer to it as the Large Spectral Library (LSL) problem. We show how to determine if unique identiŻcation is possible for any given library. We also show that if p is small compared to the number of spectral channels, it is very likely that unique identiŻcation is possible. We show that unique identiŻcation becomes less likely as p increases.

  2. 2005 Pearson Education South Asia Pte Ltd Applied Fluid Mechanics

    E-Print Network [OSTI]

    Leu, Tzong-Shyng "Jeremy"

    Education South Asia Pte Ltd Applied Fluid Mechanics 17.Drag and Lift 18.Fans, Blowers, Compressors problems. · Define the conditions that must be met for a body to be stable when completely submerged of types of buoyancy problems. #12;4 5. Buoyancy and Stability ©2005 Pearson Education South Asia Pte Ltd 5

  3. 2005 Pearson Education South Asia Pte Ltd Applied Fluid Mechanics

    E-Print Network [OSTI]

    Leu, Tzong-Shyng "Jeremy"

    Education South Asia Pte Ltd Applied Fluid Mechanics 17.Drag and Lift 18.Fans, Blowers, Compressors Chapter Outline 1. Introductory Concepts 2. Class I Systems 3. Spreadsheet Aid for Class I Problems 4 problems can be classified into three classes as follows: Class I The system is completely defined in terms

  4. 2005 Pearson Education South Asia Pte Ltd Applied Fluid Mechanics

    E-Print Network [OSTI]

    Leu, Tzong-Shyng "Jeremy"

    Education South Asia Pte Ltd Applied Fluid Mechanics 17.Drag and Lift 18.Fans, Blowers, Compressors-Momentum Equation 4. Problem-Solving Method Using the Force Equations 5. Forces on Stationary Objects 6. Forces Pearson Education South Asia Pte Ltd 16.2 Force Equation · In fluid flow problems, a continuous flow

  5. Problem solving strategies in an online homework environment

    E-Print Network [OSTI]

    Problem solving strategies in an online homework environment: "Student Choice and Analytics" Daniel.T. Seaton, MIT Online Environment using LON-CAPA · Integrated Learning Environment for Mechanics - Built within LON-CAPA - E-text with instructor videos - Concept questions - Easy, Medium, Hard homework

  6. Percutaneous Stent-Graft Repair of a Mycotic Pulmonary Artery Pseudoaneurysm

    SciTech Connect (OSTI)

    Chou Meichun; Liang Hueilung, E-mail: hlliang@isca.vghks.gov.tw; Pan Huayban; Yang Chienfang [Kaohsiung Veterans General Hospital, Department of Radiology (China)

    2006-10-15T23:59:59.000Z

    Ruptured mycotic pulmonary pseudoaneurysm is a lethal complication. Emergent surgical repair is usually recommended, but still associated with a high mortality rate. We present a patient in whom mycotic pulmonary pseudoaneurysm was a complication after surgical lobectomy 2 weeks earlier. This patient had suffered from repeated massive hemoptysis. After emergent surgical repair of the ruptured pulmonary artery stump, another episode of massive hemorrhage occurred. The pulmonary arteriogram revealed a segmental stenosis and a large, wide-necked, lobulated pseudoaneurysm at the left proximal pulmonary artery. We deployed a balloon-expandable stent-graft (48 mm in length mounted on a 12 mm x 40 mm angioplasty balloon) across the stenotic segment and the neck of the pulmonary pseudoaneurysm. Hemostasis was achieved immediately and, under a 4-week antibiotic treatment, patient was transferred to a local hospital for medical care. This case report demonstrates the benefit of minimally invasive endovascular therapy in a critically ill patient. A literature review of the etiology and management of mycotic pulmonary pseudoaneurysm is included.

  7. Operational results of shaft repair by installing stave type cooler at Kimitsu Nos. 3 and 4 blast furnaces

    SciTech Connect (OSTI)

    Oda, Hiroshi; Amano, Shigeru; Sakamoto, Aiichiro; Anzai, Osamu [Nippon Steel Corp., Kimitsu, Chiba (Japan). Kimitsu Works; Nakagome, Michiru; Kuze, Toshisuke [Nippon Steel Corp., Futtsu, Chiba (Japan); Imuta, Akira [Nippon Steel Corp., Tokyo (Japan). Plant and Machinery Div.

    1997-12-31T23:59:59.000Z

    Nos. 3 and 4 blast furnaces in Nippon Steel Corporation Kimitsu Works were both initially fitted with cooling plate systems. With the aging of each furnace, the damage to their respective inner-shaft profiles had become serious. Thus, in order to prevent operational change and prolong the furnace life, the inner-shaft profile of each furnace was repaired by replacing the former cooling plate system with the stave type cooler during the two-week-shutdowns. With this repair, stability of burden descent and gas flow near the wall part of the furnace have been achieved. Thus the prolongation of the furnace life is naturally expected.

  8. Computationally efficient Bayesian inference for inverse problems.

    SciTech Connect (OSTI)

    Marzouk, Youssef M.; Najm, Habib N.; Rahn, Larry A.

    2007-10-01T23:59:59.000Z

    Bayesian statistics provides a foundation for inference from noisy and incomplete data, a natural mechanism for regularization in the form of prior information, and a quantitative assessment of uncertainty in the inferred results. Inverse problems - representing indirect estimation of model parameters, inputs, or structural components - can be fruitfully cast in this framework. Complex and computationally intensive forward models arising in physical applications, however, can render a Bayesian approach prohibitive. This difficulty is compounded by high-dimensional model spaces, as when the unknown is a spatiotemporal field. We present new algorithmic developments for Bayesian inference in this context, showing strong connections with the forward propagation of uncertainty. In particular, we introduce a stochastic spectral formulation that dramatically accelerates the Bayesian solution of inverse problems via rapid evaluation of a surrogate posterior. We also explore dimensionality reduction for the inference of spatiotemporal fields, using truncated spectral representations of Gaussian process priors. These new approaches are demonstrated on scalar transport problems arising in contaminant source inversion and in the inference of inhomogeneous material or transport properties. We also present a Bayesian framework for parameter estimation in stochastic models, where intrinsic stochasticity may be intermingled with observational noise. Evaluation of a likelihood function may not be analytically tractable in these cases, and thus several alternative Markov chain Monte Carlo (MCMC) schemes, operating on the product space of the observations and the parameters, are introduced.

  9. Inhibition of X-ray-induced potentially lethal damage (PLD) repair in aerobic plateau-phase Chinese hamster cells by misonidazole

    SciTech Connect (OSTI)

    Brown, D.M.

    1984-01-01T23:59:59.000Z

    The effect of the 2-nitroimidazole radiosensitizer misonidazole (MISO) and the hydrophilic analog SR-2508 on the repair of X-ray-induced potentially lethal damage (PLD) was studied in plateau-phase Chinese Hamster ovary (HA-1) cells. It was found that although MISO does not radiosensitize aerobic cells, it inhibits the repair of PLD. However, under hypoxic conditions, MISO has no effect on PLD repair. The major portion of the inhibition of PLD repair in aerobic cells requires the presence of MISO only during irradiation; little or no additional inhibition occurs when MISO is present during the postirradiation repair period. Also, treatment of aerobic cells with 5 mM MISO for either 5 or 30 min prior to irradiation is equally inhibitory. This suggests that the presence of MISO in some way modifies the initial lesion under aerobic conditions since it does not increase cell killing as determined by immediate plating but inhibits subsequent repair. The inhibition is concentration dependent; 0.5 mM MISO inhibits PLD repair by one-half while 5-10 mM totally inhibits the repair measured 6 hr postirradiation. This phenomenon suggests that radiosensitization of tissue in vivo by MISO and other 2-nitroimidazoles may not be unequivocal proof of the presence of hypoxic cells.

  10. Subj: Educational and General (E&G) Facility Support Provide an overview of Facility Operations, Maintenance, Repair and Renovation and Space

    E-Print Network [OSTI]

    support, and, preventive and unscheduled maintenance of all building systems, with the exception of BAS Operations, Maintenance, Repair and Renovation and Space Management Procedures and Practices. KEY DEFINITIONS chambers, fume hoods, fixed seating, etc. are normally considered part of the building. Maintenance, repair

  11. Performance and Impact from Duct Repair and Ventilation Modifications of Two Newly Constructed Manufactured Houses Located in a Hot and Humid Climate

    E-Print Network [OSTI]

    Withers, C.; Moyer, N.; Chasar, D.; Chandra, S.

    2002-01-01T23:59:59.000Z

    airtightness was adjusted until it was the same in each house, and duct leaks were sealed so that the ducts were tight and there was equal tightness in both houses. A ventilation system was also added at the same time of duct repair. Duct repair...

  12. Nonlocal models in continuum mechanics

    SciTech Connect (OSTI)

    Johnson, N.L. [Los Alamos National Lab., NM (United States); Phan-Thien, N. [Sydney Univ., NSW (Australia). Dept. of Mechanical Engineering

    1993-09-01T23:59:59.000Z

    The recent appearance of nonlocal methods is examined in the light of traditional continuum mechanics. A comparison of nonlocal approaches in the fields of solid and fluid mechanics reveals that no consistent definition of a nonlocal theory has been used. We suggest a definition based on the violation of the principle of local action in continuum mechanics. From the consideration of the implications of a nonlocal theory based on this definition, we conclude that constitutive relations with nonlocal terms can confuse the traditional separation of the roles between conservation laws and constitutive relations. The diversity of motivations for the nonlocal approaches are presented, resulting primarily from deficiencies in numerical solutions to practical problems. To illustrate these concepts, the history of nonlocal terms in the field of viscoelastic fluids is reviewed. A specific example of a viscoelastic constitutive relation that contains a stress diffusion term is applied to a simple shear flow and found not to be a physical description of any known fluid. We conclude by listing questions that should be asked of nonlocal approaches.

  13. Scalable Mechanisms for Rational Secret Sharing

    E-Print Network [OSTI]

    Dani, Varsha; Saia, Jared

    2012-01-01T23:59:59.000Z

    We consider the classical secret sharing problem in the case where all agents are selfish but rational. In recent work, Kol and Naor show that, when there are two players, in the non-simultaneous communication model, i.e. when rushing is possible, there is no Nash equilibrium that ensures both players learn the secret. However, they describe a mechanism for this problem, for any number of players, that is an epsilon-Nash equilibrium, in that no player can gain more than epsilon utility by deviating from it. Unfortunately, the Kol and Naor mechanism, and, to the best of our knowledge, all previous mechanisms for this problem require each agent to send O(n) messages in expectation, where n is the number of agents. This may be problematic for some applications of rational secret sharing such as secure multi-party computation and simulation of a mediator. We address this issue by describing mechanisms for rational secret sharing that are designed for large n. Both of our results hold for n > 2, and are Nash equil...

  14. Semidefinite Relaxations of Ordering Problems

    E-Print Network [OSTI]

    2011-01-19T23:59:59.000Z

    Jan 19, 2011 ... from z? only in an additive constant. We are now dropping the ...... Machine Layout Problem in Flexible Manufacturing Systems. Operations.

  15. Pooling problems: relaxations and discretizations

    E-Print Network [OSTI]

    2013-09-02T23:59:59.000Z

    also possible to send flow directly from inputs to the outputs. ... mid-term planning problem that is designed to answer the optimal process control decisions in.

  16. Inverse Problems in Transport Theory

    E-Print Network [OSTI]

    The inverse scattering problem for (2.1) is the following: Does S determine ...... J. Voigt, Spectral properties of the neutron transport equation, J. Math. Anal. Appl.

  17. Graduate School Engineering Mechanics

    E-Print Network [OSTI]

    Franssen, Michael

    Mechanics c/o Eindhoven University of Technology PO Box 513, building W-hoog 2.113 5600 MB Eindhoven NL Tel on Engineering Mechanics, a joint initiative of the Eindhoven and Delft Universities of Technology Mechanics c/o Eindhoven University of Technology PO Box 513, building W-hoog 2.113 5600 MB Eindhoven NL

  18. Mechanical & Industrial Engineering

    E-Print Network [OSTI]

    Mountziaris, T. J.

    Mechanical & Industrial Engineering Mario A. Rotea Professor and Department Head #12;2Mechanical & Industrial Engineering Outline · Undergraduate Degree Programs · Graduate Degree Programs · The Faculty · The Research · Summary #12;3Mechanical & Industrial Engineering Undergraduate Programs ­ BSME & BSIE 0 20 40 60

  19. UNSATURATED SOIL MECHANICS IMPLEMENTATION

    E-Print Network [OSTI]

    Minnesota, University of

    UNSATURATED SOIL MECHANICS IMPLEMENTATION DURING PAVEMENT CONSTRUCTION QUALITY ASSURANCE Mn !! Performance Based Construction QA !! Unsaturated Soil Mechanics !! What We've Learned !! Next Steps #12.6-6.0 5 - 7 19 0.8 5 7 - 9 24 1.1 4 9 - 11 28 1.2 4 #12;Unsaturated Soil Mechanics #12;Fundamentals

  20. Mechanical & Aerospace Engineering

    E-Print Network [OSTI]

    Mechanical & Aerospace Engineering An experimental methodology is presented for mechanism Yang is a second graduate student in the department of mechanical engineering of ASU. He received his Jian Yang School for Engineering of Matter, Transport and Energy Arizona State University October 5

  1. Mechanical engineering Department Seminar

    E-Print Network [OSTI]

    efficient energy systems. Evelyn N. Wang is an Associate Professor in the Mechanical Engineering DepartmentMechanical engineering Department Seminar Evelyn Wang Depaprtment of Mechanical Engineering MIT Nanoengineered Surfaces: Transport Phenomena and Energy Applications 11:00 AM Friday, 5 April 2013 Room 245, 110

  2. Mechanical engineering Department Seminar

    E-Print Network [OSTI]

    Mechanical engineering Department Seminar Domitilla Del Vecchio Department of Mechanical. A near future is envisioned in which re- engineered bacteria will turn waste into energy and kill cancer, she joined the Department of Mechanical Engineering and the Laboratory for Information and Decision

  3. Mechanical & Aerospace Engineering

    E-Print Network [OSTI]

    in Mechanical Engineering at the School for Engineering of Matter, Transport and Energy, working in Dr. MarcusMechanical & Aerospace Engineering The atomization of a liquid jet by a high speed cross.S.E. degree in mechanical engineering from Amirkabir University of Technology in 2006 and M.S. degree

  4. Optimization problems with value function objectives

    E-Print Network [OSTI]

    2011-11-01T23:59:59.000Z

    max programming problem and the bilevel optimization problem. In this paper, we ... 1. Introduction. An optimization problem with value function objective is a.

  5. The Traveling Salesman Problem with Flexible Coloring

    E-Print Network [OSTI]

    Roemer, T. A.; Ahmadi, R.; Dasu, S.

    2011-01-01T23:59:59.000Z

    Salesman Problem with Flexible Coloring Thomas A. Roemer TheSalesman Problem with Flexible Colors (? ?? ?? ). We note,Salesman Problem with Flexible Colors (? ?? ?? ) can

  6. Mechanical seal assembly

    DOE Patents [OSTI]

    Kotlyar, Oleg M. (Salt Lake City, UT)

    2001-01-01T23:59:59.000Z

    An improved mechanical seal assembly is provided for sealing rotating shafts with respect to their shaft housings, wherein the rotating shafts are subject to substantial axial vibrations. The mechanical seal assembly generally includes a rotating sealing ring fixed to the shaft, a non-rotating sealing ring adjacent to and in close contact with the rotating sealing ring for forming an annular seal about the shaft, and a mechanical diode element that applies a biasing force to the non-rotating sealing ring by means of hemispherical joint. The alignment of the mechanical diode with respect to the sealing rings is maintained by a series of linear bearings positioned axially along a desired length of the mechanical diode. Alternative embodiments include mechanical or hydraulic amplification components for amplifying axial displacement of the non-rotating sealing ring and transferring it to the mechanical diode.

  7. Mechanical seal assembly

    DOE Patents [OSTI]

    Kotlyar, Oleg M. (Salt Lake City, UT)

    2002-01-01T23:59:59.000Z

    An improved mechanical seal assembly is provided for sealing rotating shafts with respect to their shaft housings, wherein the rotating shafts are subject to substantial axial vibrations. The mechanical seal assembly generally includes a rotating sealing ring fixed to the shaft, a non-rotating sealing ring adjacent to and in close contact with the rotating sealing ring for forming an annular seal about the shaft, and a mechanical diode element that applies a biasing force to the non-rotating sealing ring by means of hemispherical joint. The alignment of the mechanical diode with respect to the sealing rings is maintained by a series of linear bearings positioned axially along a desired length of the mechanical diode. Alternative embodiments include mechanical or hydraulic amplification components for amplifying axial displacement of the non-rotating sealing ring and transfering it to the mechanical diode.

  8. Declarative Problem Solving through Abduction

    E-Print Network [OSTI]

    Moraitis, Pavlos

    1 Declarative Problem Solving through Abduction Antonis C. Kakas Department of Computer Science, 2007 Paris, France #12;2 Course Breakdown · Introduction · Abduction ­ General Introduction · Modelling Problems for Abduction and DPS · Computational Logic & PROLOG ­ Background · Abductive Logic Programming

  9. MATRIXDEPENDENT MULTIGRIDHOMOGENIZATION FOR DIFFUSION PROBLEMS

    E-Print Network [OSTI]

    Bebendorf, Mario

    , such as matrix­ dependent prolongations and the construction of coarse­grid operators by means of the Galerkin. Introduction. Solutions for problems which model locally strong varying phe­ nomena on a micro­scale level require that all length scales present in the problem are completely resolved. However, due to storage

  10. PROBLEM SETS: Fundamentals of Transportation

    E-Print Network [OSTI]

    Daganzo, Carlos F.

    on the publications section of Carlos Daganzo's world wide web home page at http improved the wording, graphics and notation of many of the problems, and facilitated the internet comments on several problem statements. Thanks also go to Ms. Alison Andreas for her excellent word

  11. Problems associated with the establishment of a whole body counter at a university reactor 

    E-Print Network [OSTI]

    Fairchild, Gregory R

    1999-01-01T23:59:59.000Z

    A widd variety of difficulties can arise in bringing a ics. whole body counting chair into operation for screening radiation workers. Problems can arise in the mechanical operation of the chair, in fabrication of phantom ...

  12. A systematic approach to recurring event/problem determination

    SciTech Connect (OSTI)

    Futrell, R.C.

    1990-06-01T23:59:59.000Z

    This paper describes the basic elements and systematic process developed at Duke Power Company for determining recurring events and recurring problems. The first basic element used to support this process is the problem investigation report (PIR) program. The PIR program serves as the mechanism by which US Nuclear Regulatory Commission (NRC) reportable and nonreportable events and problems are identified, investigated, and resolved. The second basic element used to support this process is the in-house operating experience (OE) computerized data base. This data base contains information specific to each event and designed to facilitate data manipulation and sorting. Finally, the recurring event/problem guideline has been developed to systematically lead the user through the process using the PIR and OE programs. This paper very briefly describes the PIR data-handling process and summarizes the major changes to the process.

  13. The Effect of Debris on Collector Optics, its Mitigation and Repair: Next-Step a Gaseous Sn EUV DPP Source

    E-Print Network [OSTI]

    Spila, Timothy P.

    The Effect of Debris on Collector Optics, its Mitigation and Repair: Next-Step a Gaseous Sn EUV DPP to advanced fuel plasma EUV sources is collector lifetime. The Illinois Debris-mitigation EUV Applications based on this work. Keywords: EUV source, debris, optics, collector lifetime, mitigation, plasma

  14. Image-Guided Techniques Improve the Short-term Outcome of Autologous Osteochondral Cartilage Repair Surgeries -An

    E-Print Network [OSTI]

    Stewart, James

    Image-Guided Techniques Improve the Short-term Outcome of Autologous Osteochondral Cartilage Repair and deliver osteochondral grafts remains problematic. We investigated whether image-guided methods (optically-guided and template-guided) can improve the outcome of mo- saic arthroplasty procedures. Methods: Fifteen sheep were

  15. Diet-dependent survival of protein repair-deficient miceB Christine E. Farrar, Steven ClarkeT

    E-Print Network [OSTI]

    Clarke, Steven

    Diet-dependent survival of protein repair-deficient miceB Christine E. Farrar, Steven Clarke, and mice lacking this enzyme accumulate damaged proteins in multiple tissues, die at an early age from and in vivo [1­7]. Mice lacking the enzyme (Pcmt1Ŕ/Ŕ mice) accu- mulate damaged proteins in multiple tissues

  16. Homologous recombination contributes to the repair of DNA double-strand breaks induced by high-energy iron ions

    SciTech Connect (OSTI)

    Zafar, Faria; Seidler, Sara B.; Kronenberg, Amy; Schild, David; Wiese, Claudia

    2010-06-29T23:59:59.000Z

    To test the contribution of homologous recombinational repair (HRR) in repairing DNA damaged sites induced by high-energy iron ions, we used: (1) HRR-deficient rodent cells carrying a deletion in the RAD51D gene and (2) syngeneic human cells impaired for HRR by RAD51D or RAD51 knockdown using RNA interference. We show that in response to iron ions, HRR contributes to cell survival in rodent cells, and that HRR-deficiency abrogates RAD51 foci formation. Complementation of the HRR defect by human RAD51D rescues both enhanced cytotoxicity and RAD51 foci formation. For human cells irradiated with iron ions, cell survival is decreased, and, in p53 mutant cells, the levels of mutagenesis are increased when HRR is impaired. Human cells synchronized in S phase exhibit more pronounced resistance to iron ions as compared with cells in G1 phase, and this increase in radioresistance is diminished by RAD51 knockdown. These results implicate a role for RAD51-mediated DNA repair (i.e. HRR) in removing a fraction of clustered lesions induced by charged particle irradiation. Our results are the first to directly show the requirement for an intact HRR pathway in human cells in ensuring DNA repair and cell survival in response to high-energy high LET radiation.

  17. A review of "To Repair the Ruins: Reading Milton" edited by Mary C. Fenton and Louis Schwartz

    E-Print Network [OSTI]

    Welch, Anthony

    2013-01-01T23:59:59.000Z

    that deserve the attention he gives them. Mary C. Fenton and Louis Schwartz, eds. To Repair the Ruins: Reading Milton. Pittsburgh: Duquesne University Press, #18;#17;#16;#18;. xii + #1;#30; pp. + #18;#18; illus. $#14;#15;.#17;#17;. Review by #8...

  18. Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair

    SciTech Connect (OSTI)

    Chen, Xi; Ballin, Jeff D.; Della-Maria, Julie; Tsai, Miaw-Sheue; White, Elizabeth J.; Tomkinson, Alan E.; Wilson, Gerald M.

    2009-05-11T23:59:59.000Z

    The three human LIG genes encode polypeptides that catalyze phosphodiester bond formation during DNA replication, recombination and repair. While numerous studies have identified protein partners of the human DNA ligases (hLigs), there has been little characterization of the catalytic properties of these enzymes. In this study, we developed and optimized a fluorescence-based DNA ligation assay to characterize the activities of purified hLigs. Although hLigI joins DNA nicks, it has no detectable activity on linear duplex DNA substrates with short, cohesive single-strand ends. By contrast, hLigIII{beta} and the hLigIII{alpha}/XRCC1 and hLigIV/XRCC4 complexes are active on both nicked and linear duplex DNA substrates. Surprisingly, hLigIV/XRCC4, which is a key component of the major non-homologous end joining (NHEJ) pathway, is significantly less active than hLigIII on a linear duplex DNA substrate. Notably, hLigIV/XRCC4 molecules only catalyze a single ligation event in the absence or presence of ATP. The failure to catalyze subsequent ligation events reflects a defect in the enzyme-adenylation step of the next ligation reaction and suggests that, unless there is an in vivo mechanism to reactivate DNA ligase IV/XRCC4 following phosphodiester bond formation, the cellular NHEJ capacity will be determined by the number of adenylated DNA ligaseIV/XRCC4 molecules.

  19. Design structure for in-system redundant array repair in integrated circuits

    DOE Patents [OSTI]

    Bright, Arthur A.; Crumley, Paul G.; Dombrowa, Marc; Douskey, Steven M.; Haring, Rudolf A.; Oakland, Steven F.; Quellette, Michael R.; Strissel, Scott A.

    2008-11-25T23:59:59.000Z

    A design structure for repairing an integrated circuit during operation of the integrated circuit. The integrated circuit comprising of a multitude of memory arrays and a fuse box holding control data for controlling redundancy logic of the arrays. The design structure provides the integrated circuit with a control data selector for passing the control data from the fuse box to the memory arrays; providing a source of alternate control data, external of the integrated circuit; and connecting the source of alternate control data to the control data selector. The design structure further passes the alternate control data from the source thereof, through the control data selector and to the memory arrays to control the redundancy logic of the memory arrays.

  20. Designer's guidebook for first wall/blanket/shield assembly, maintenance, and repair

    SciTech Connect (OSTI)

    Not Available

    1983-12-30T23:59:59.000Z

    This is the initial issue of the guidebook. Since a guidebook of this type must incorporate information concerning a wide range of subjects, much additional data will eventually be included. The guidebook will document, in summary and easily referenceable form, data, designs, design concepts, design guidelines and background information useful to the FWBS and to the Maintenance System designer. In providing guidelines for the AMR of the FWBS, the guidebook must, of necessity, include guidelines for all aspects of maintenance associated with the FWBS. These include most maintenance operations within the reactor room necessary to gain access, identify faults, and handle equipment related to FWBS maintenance. In addition, the guidelines include those required to define facility requirements for handling and repair of FWBS and related reactor components external to the reactor room. Particular emphasis is given to remote maintenance design and operations.

  1. Quantum Mechanics, Gravity, and the Multiverse

    E-Print Network [OSTI]

    Yasunori Nomura

    2012-07-30T23:59:59.000Z

    The discovery of accelerating expansion of the universe has led us to take the dramatic view that our universe may be one of the many universes in which low energy physical laws take different forms: the multiverse. I explain why/how this view is supported both observationally and theoretically, especially by string theory and eternal inflation. I then describe how quantum mechanics plays a crucial role in understanding the multiverse, even at the largest distance scales. The resulting picture leads to a revolutionary change of our view of spacetime and gravity, and completely unifies the paradigm of the eternally inflating multiverse with the many worlds interpretation of quantum mechanics. The picture also provides a solution to a long-standing problem in eternal inflation, called the measure problem, which I briefly describe.

  2. Mechanical engineering Department Seminar

    E-Print Network [OSTI]

    Lin, Xi

    operating in microfluidic environment, which can dynamically diverge, collimate and focus surface plasmons in 2012, with a joint appointment in the Department of Mechanical & Industrial Engineering

  3. Mechanical engineering Department Seminar

    E-Print Network [OSTI]

    Research Center. Currently he is an Assistant Prof. in the Aerospace and Ocean Engineering DepartmentMechanical engineering Department Seminar Cornel Sultan Virginia Tech Design for Control

  4. The problem of non-renewable energy resources in the production of physical capital

    E-Print Network [OSTI]

    Nesterov, Yurii

    2007/8 The problem of non-renewable energy resources in the production of physical capital Agustin PĂ©rez-Barahona #12;CORE DISCUSSION PAPER 2007/8 The problem of non-renewable energy resources-run growth, although energy is produced by means of non-renewable energy resources. The mechanism behind

  5. Surrogate Guderley Test Problem Definition

    SciTech Connect (OSTI)

    Ramsey, Scott D. [Los Alamos National Laboratory; Shashkov, Mikhail J. [Los Alamos National Laboratory

    2012-07-06T23:59:59.000Z

    The surrogate Guderley problem (SGP) is a 'spherical shock tube' (or 'spherical driven implosion') designed to ease the notoriously subtle initialization of the true Guderley problem, while still maintaining a high degree of fidelity. In this problem (similar to the Guderley problem), an infinitely strong shock wave forms and converges in one-dimensional (1D) cylindrical or spherical symmetry through a polytropic gas with arbitrary adiabatic index {gamma}, uniform density {rho}{sub 0}, zero velocity, and negligible pre-shock pressure and specific internal energy (SIE). This shock proceeds to focus on the point or axis of symmetry at r = 0 (resulting in ostensibly infinite pressure, velocity, etc.) and reflect back out into the incoming perturbed gas.

  6. Mathematical Problems of Thermoacoustic Tomography 

    E-Print Network [OSTI]

    Nguyen, Linh V.

    2010-10-12T23:59:59.000Z

    Thermoacoustic tomography (TAT) is a newly emerging modality in biomedical imaging. It combines the good contrast of electromagnetic and good resolution of ultrasound imaging. The mathematical model of TAT is the observability problem for the wave...

  7. SOME COMPUTATIONAL PROBLEMS IN MICROFLUIDICS.

    E-Print Network [OSTI]

    Colin, Thierry

    SOME COMPUTATIONAL PROBLEMS IN MICROFLUIDICS. S. Tancogne, Ch.-H. Bruneau, Th. Colin Institut de is to present some results of flow simulations in microflu- idics. Microfluidics is characterized

  8. Industrial Mathematics and Inverse Problems

    E-Print Network [OSTI]

    Fulmek, Markus

    #12;The Industrial Mathematics Structure in Linz 5 #12;The Blast Furnace Process 6 #12;Aims": Looking for causes of an observed or desired effect! A.Tikhonov ( 1936), geophysical problems. F

  9. BILEVEL OPTIMIZATION PROBLEMS WITH VECTORVALUED ...

    E-Print Network [OSTI]

    2012-05-21T23:59:59.000Z

    Page 1 ... been topic of a large number of articles, see the bibliography [8], and of at least two monographs [2, 7]. If the optimal solution of the problem (1.1) is not ...

  10. Galois Groups of Schubert Problems

    E-Print Network [OSTI]

    Martin Del Campo Sanchez, Abraham

    2012-10-19T23:59:59.000Z

    GALOIS GROUPS OF SCHUBERT PROBLEMS A Dissertation by ABRAHAM MARTIN DEL CAMPO SANCHEZ Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY... August 2012 Major Subject: Mathematics GALOIS GROUPS OF SCHUBERT PROBLEMS A Dissertation by ABRAHAM MARTIN DEL CAMPO SANCHEZ Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements...

  11. Applied quantum mechanics 1 Applied Quantum Mechanics

    E-Print Network [OSTI]

    Levi, Anthony F. J.

    3D T 0 K( ) 3 5 ---EF= E3D T K( ) 3 2 ---kBT= E2D T 0 K( ) 1 2 ---EF= E2D T K( ) kBT= a x1 x2 . Your answer should include a print out of your computer program and plots. Problem 7.2 (a) Show that (b) A semiconductor consists of a valance band with electron energy dispersion relation and a conduction band

  12. MECHANICAL ENGINEERING Program of Study

    E-Print Network [OSTI]

    Thomas, Andrew

    offers graduate programs in the fields of thermal science and engineering mechanics. Current areasMECHANICAL ENGINEERING Program of Study Correspondence The Department of Mechanical Engineering of research activity include Biomedical Engineering, Biomimetics, Composite Materials, Computational Mechanics

  13. Solar mechanics thermal response capabilities.

    SciTech Connect (OSTI)

    Dobranich, Dean D.

    2009-07-01T23:59:59.000Z

    In many applications, the thermal response of structures exposed to solar heat loads is of interest. Solar mechanics governing equations were developed and integrated with the Calore thermal response code via user subroutines to provide this computational simulation capability. Solar heat loads are estimated based on the latitude and day of the year. Vector algebra is used to determine the solar loading on each face of a finite element model based on its orientation relative to the sun as the earth rotates. Atmospheric attenuation is accounted for as the optical path length varies from sunrise to sunset. Both direct and diffuse components of solar flux are calculated. In addition, shadowing of structures by other structures can be accounted for. User subroutines were also developed to provide convective and radiative boundary conditions for the diurnal variations in air temperature and effective sky temperature. These temperature boundary conditions are based on available local weather data and depend on latitude and day of the year, consistent with the solar mechanics formulation. These user subroutines, coupled with the Calore three-dimensional thermal response code, provide a complete package for addressing complex thermal problems involving solar heating. The governing equations are documented in sufficient detail to facilitate implementation into other heat transfer codes. Suggestions for improvements to the approach are offered.

  14. Probable Inference and Quantum Mechanics

    SciTech Connect (OSTI)

    Grandy, W. T. Jr. [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82070 (United States)

    2009-12-08T23:59:59.000Z

    In its current very successful interpretation the quantum theory is fundamentally statistical in nature. Although commonly viewed as a probability amplitude whose (complex) square is a probability, the wavefunction or state vector continues to defy consensus as to its exact meaning, primarily because it is not a physical observable. Rather than approach this problem directly, it is suggested that it is first necessary to clarify the precise role of probability theory in quantum mechanics, either as applied to, or as an intrinsic part of the quantum theory. When all is said and done the unsurprising conclusion is that quantum mechanics does not constitute a logic and probability unto itself, but adheres to the long-established rules of classical probability theory while providing a means within itself for calculating the relevant probabilities. In addition, the wavefunction is seen to be a description of the quantum state assigned by an observer based on definite information, such that the same state must be assigned by any other observer based on the same information, in much the same way that probabilities are assigned.

  15. Yale University Mechanical Engineering

    E-Print Network [OSTI]

    Dollar, Aaron M.

    ) ­ #92474A029 (4x) #12;OpenHand Yale University Mechanical Engineering 3D Printer Requirements · Current · Majority of parts are designed to not require support material · Authors do not know how well alternate 3D printers will produce adequate components #12;OpenHand Yale University Mechanical Engineering Finger

  16. Respiratory Mechanisms of Support

    E-Print Network [OSTI]

    Kay, Mark A.

    Respiratory Mechanisms of Support Nasal Cannula Hi Flow Nasal Cannula CPAP Continuous positive the respiratory system is working to compensate for a metabolic issue so as to normalize the blood pH. HCO3 - 22 uses PIP Mechanical Ventilation: Volume vs. Pressure: Volume Control Pressure Control Cycle Volume Time

  17. Department of Mechanical Engineering

    E-Print Network [OSTI]

    Srivastava, Kumar Vaibhav

    Explore and understand applicable science Create new materials #12;Indian Railways #12;Wheel Impact Load automated system for On-Line estimation of Wheel Impact Loads and detection of Wheel Flats of running trains Detection System (WILD) #12;Derailment Mechanism Laboratory Tests Lab Brake Mechanism Placement of Sensors

  18. Mechanical engineering Department Seminar

    E-Print Network [OSTI]

    Lin, Xi

    Mechanical engineering Department Seminar Junjie Niu Postdoctoral Associate MIT Engineering Nano nanomaterials in applications of energy storage, biomedicine and chemo-mechanics. In 2007, Dr.Niu received young-structured Materials for Energy Storage 11:00 AM Friday, 14 February 2014 Room 245, 110 Cummington Mall Refreshments

  19. Mechanical and Aerospace Engineering

    E-Print Network [OSTI]

    Mechanical and Aerospace Engineering Abstract Solid materials used in energy conversion and storage Department of Civil & Environmental Engineering, Department of Mechanical Engineering, Northwestern University April 6, 2012 at 2:00pm in SCOB 252 School for Engineering of Matter, Transport & Energy #12;

  20. Mechanical & Aerospace Engineering

    E-Print Network [OSTI]

    Mechanical & Aerospace Engineering The development of high-energy storage devices has been one energy capacity over 500 cycles. Teng Ma received his BS degree in Thermal and Power Engineering from Xi and Technology of China in 2009. He is currently a Ph.D. candidate in Mechanical Engineering at School

  1. periodica polytechnica Mechanical Engineering

    E-Print Network [OSTI]

    Gubicza, Jenő

    structure. Keywords aluminium alloys · nanostructured materials · mechanical characterization · X-thickness texture gradient produced by the different routes of DSR have been studied in Al 1050 aluminium alloy [15 routes on the microstructure and mechanical properties of Al 7075 aluminium alloy. Microstructure

  2. Low-energy Supersymmetry Breaking Without the Gravitino Problem

    E-Print Network [OSTI]

    Hook, Anson

    2015-01-01T23:59:59.000Z

    In models of low-energy gauge mediation, the observed Higgs mass is in tension with the cosmological limit on the gravitino mass $m_{3/2} \\lesssim 16$ eV. We present an alternative mediation mechanism of supersymmetry breaking via a $U(1)$ $D$-term with an $E_6$-inspired particle content, which we call "vector mediation". The gravitino mass can be in the eV range. The sfermion masses are at the 10 TeV scale, while gauginos around a TeV. This mechanism also greatly ameliorates the $\\mu$-problem.

  3. CrowdPhase: crowdsourcing the phase problem

    SciTech Connect (OSTI)

    Jorda, Julien; Sawaya, Michael R. [Institute for Genomics and Proteomics, 611 Charles Young Drive East, Los Angeles, CA 90095 (United States); Yeates, Todd O., E-mail: yeates@mbi.ucla.edu [Institute for Genomics and Proteomics, 611 Charles Young Drive East, Los Angeles, CA 90095 (United States); Molecular Biology Institute, 611 Charles Young Drive East, Los Angeles, CA 90095 (United States); University of California, 611 Charles Young Drive East, Los Angeles, CA 90095 (United States)

    2014-06-01T23:59:59.000Z

    The idea of attacking the phase problem by crowdsourcing is introduced. Using an interactive, multi-player, web-based system, participants work simultaneously to select phase sets that correspond to better electron-density maps in order to solve low-resolution phasing problems. The human mind innately excels at some complex tasks that are difficult to solve using computers alone. For complex problems amenable to parallelization, strategies can be developed to exploit human intelligence in a collective form: such approaches are sometimes referred to as ‘crowdsourcing’. Here, a first attempt at a crowdsourced approach for low-resolution ab initio phasing in macromolecular crystallography is proposed. A collaborative online game named CrowdPhase was designed, which relies on a human-powered genetic algorithm, where players control the selection mechanism during the evolutionary process. The algorithm starts from a population of ‘individuals’, each with a random genetic makeup, in this case a map prepared from a random set of phases, and tries to cause the population to evolve towards individuals with better phases based on Darwinian survival of the fittest. Players apply their pattern-recognition capabilities to evaluate the electron-density maps generated from these sets of phases and to select the fittest individuals. A user-friendly interface, a training stage and a competitive scoring system foster a network of well trained players who can guide the genetic algorithm towards better solutions from generation to generation via gameplay. CrowdPhase was applied to two synthetic low-resolution phasing puzzles and it was shown that players could successfully obtain phase sets in the 30° phase error range and corresponding molecular envelopes showing agreement with the low-resolution models. The successful preliminary studies suggest that with further development the crowdsourcing approach could fill a gap in current crystallographic methods by making it possible to extract meaningful information in cases where limited resolution might otherwise prevent initial phasing.

  4. DNA Twist Elasticity: Mechanics and Thermal Fluctuations

    E-Print Network [OSTI]

    Supurna Sinha; Joseph Samuel

    2010-11-30T23:59:59.000Z

    The elastic properties of semiflexible polymers are of great importance in biology. There are experiments on biopolymers like double stranded DNA, which twist and stretch single molecules to probe their elastic properties. It is known that thermal fluctuations play an important role in determining molecular elastic properties, but a full theoretical treatment of the problem of twist elasticity of fluctuating ribbons using the simplest worm like chain model (WLC) remains elusive. In this paper, we approach this problem by taking first a mechanical approach and then incorporating thermal effects in a quadratic approximation applying the Gelfand-Yaglom (GY) method for computing fluctuation determinants. Our study interpolates between mechanics and statistical mechanics in a controlled way and shows how profoundly thermal fluctuations affect the elasticity of semiflexible polymers. The new results contained here are: 1) a detailed study of the minimum energy configurations with explicit expressions for their energy and writhe and plots of the extension versus Link for these configurations. 2) a study of fluctuations around the local minima of energy and approximate analytical formulae for the free energy of stretched twisted polymers derived by the Gelfand Yaglom method. We use insights derived from our mechanical approach to suggest calculational schemes that lead to an improved treatment of thermal fluctuations. From the derived formulae, predictions of the WLC model for molecular elasticity can be worked out for comparison against numerical simulations and experiments.

  5. Mechanical code comparator

    DOE Patents [OSTI]

    Peter, Frank J. (Albuquerque, NM); Dalton, Larry J. (Bernalillo, NM); Plummer, David W. (Albuquerque, NM)

    2002-01-01T23:59:59.000Z

    A new class of mechanical code comparators is described which have broad potential for application in safety, surety, and security applications. These devices can be implemented as micro-scale electromechanical systems that isolate a secure or otherwise controlled device until an access code is entered. This access code is converted into a series of mechanical inputs to the mechanical code comparator, which compares the access code to a pre-input combination, entered previously into the mechanical code comparator by an operator at the system security control point. These devices provide extremely high levels of robust security. Being totally mechanical in operation, an access control system properly based on such devices cannot be circumvented by software attack alone.

  6. 07SCHOOL OF MECHANICAL ENGINEERING

    E-Print Network [OSTI]

    Dimitrova, Vania

    07SCHOOL OF MECHANICAL ENGINEERING UNDERGRADUATE DEGREES School of Mechanical Engineering FACULTY OF ENGINEERING Undergraduate Degrees 2015 #12;www.engineering.leeds.ac.uk/mechanical UNDERGRADUATE DEGREES SCHOOL OF MECHANICAL ENGINEERING The School of Mechanical Engineering offers both a broad mechanical engineering degree

  7. Erwin Schroedinger and the rise of wave mechanics. III. Early response and applications

    SciTech Connect (OSTI)

    Mehra, J.

    1988-02-01T23:59:59.000Z

    This article (Part III) deals with the early applications of wave mechanics to atomic problems - including the demonstration of the formal mathematical equivalence of wave mechanics with the quantum mechanics of Born, Heisenberg, and Jordan, and that of Dirac - by Schroedinger himself and others. The new theory was immediately accepted by the scientific community.

  8. Integrated design of robotic mechanisms for force balancing and trajectory tracking

    E-Print Network [OSTI]

    Zhang, WJ "Chris"

    . This disturbance causes vibration, noise, wear, and fatigue, as well as large energy consumption problems, mechanisms are driven by constant velocity motors. A real-time controllable (RTC) mechanism refers motors that are not real-time controllable (RTC). Such mechanisms can assure the coordination

  9. Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    more secure electricity for customers and will reduce our nation's dependence on fossil fuels. Many energy technologies, particularly renewables, generate direct current (DC)...

  10. Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    that could benefit from this coating process include high-definition flat panel displays, sensor coatings for both biological and chemical sensors, and low-k materials for next...

  11. Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and offset the benefits. Australia has met its water supply demand with freshwater dams and water catchments in the past, but has been unable to do so in the last decade due...

  12. Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    phosphorus oxynitride (LiPON) electrolyte and is charged by an energy harvesting PV device. Originally funded by Defense Advanced Research Projects Agency, the device...

  13. Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    solutions, Sandia and Princeton Power Systems have teamed up to develop the Demand Response Inverter (DRI). Innovative Edge The DRI is a power flow control system that...

  14. Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)IntegratedSpeedingTechnical News, informationPriority Firm

  15. Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)IntegratedSpeedingTechnical News, informationPriority FirmTech Transfer Success

  16. Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's Possible forPortsmouth/Paducah47,193.70 Hg Mercury 35 Br BromineProbing the Proton's Weak SideTech

  17. Problem

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's Possible forPortsmouth/Paducah47,193.70 Hg Mercury 35 Br BromineProbing the Proton's Weak

  18. Solving the Tulsa ozone problem

    SciTech Connect (OSTI)

    Wagner, K.K. [Atmospheric Information Systems, Norman, OK (United States); Wilson, J.D. [Wilson Consulting Group, Tulsa, OK (United States); Gibeau, E. [Aeromet Inc., Tulsa, OK (United States)

    1998-12-31T23:59:59.000Z

    Local governments and interested parties in Tulsa, Oklahoma are planning actions to keep Tulsa in compliance with the ozone ambient air quality standard. Based on recent data Tulsa exceeds the new eight hour average national ambient air quality standard for ozone and occasionally exceeds the previous one hour standard. Currently, Tulsa is in attainment of the former one-hour ozone standard. The first planning step is to integrate the existing information about Tulsa`s ozone problem. Prior studies of Tulsa ozone are reviewed. Tulsa`s recent air quality and meteorological monitoring are evaluated. Emission inventory estimates are assessed. Factors identified with Tulsa`s ozone problem are the transport of ozone and precursor gases, a possible role for biogenic emissions, and a simplistic ozone forecasting method. The integration of information found that current air quality and meteorological monitoring is meager. Observations of volatile organic compounds and NO{sub y} are absent. Prior intensive studies in 1977 and 1985 are more than ten years old and lack relevance to today`s problem. Emission inventory estimates are scarce and uncertain. The current knowledge base was judged inadequate to properly characterize the present ozone problem. Actions are recommended to enlarge the information base to address Tulsa`s ozone problem.

  19. Mechanics of dexterous manipulation

    E-Print Network [OSTI]

    Zeng, Chang

    1991-01-01T23:59:59.000Z

    Work . 1. Quasi-Statics ? Classical Analysis Approach 2. Quasi-Statics Variational Approach 3. Dynamics ? Inconsistency and Ambiguity C. Preview 2 4 4 6 8 9 II PROBLEM FORMULATION A. Fundamental Assumptions B. Mathematics . 1. Force... Equilibrium 2. Kinematic Constraints 3. Coulomb Model C, Problem Statement 11 11 12 13 14 14 III SOLUTION APPROACHES AND TIME COMPLEXITIES A. Classical Analysis Approach 1. One Linearly Independent Kinematic Equality 2. Two Linearly Independent...

  20. MOLECULAR MECHANISM OF SUPPRESSION OF NEOPLASTIC TRANSFORMATION BY LOW DOSES OF LOW LET RADIATION

    SciTech Connect (OSTI)

    J.LESIE REDPATH, PH.D.

    2011-03-29T23:59:59.000Z

    We are currently funded (9/01-8/04) by the DOE Low Dose Radiation Research Program to examine mechanisms underlying the suppression of neoplastic transformation in vitro by low doses of low LET radiation. For the new studies proposed under Notice 04-21, we intend to follow up on our observation that upregulation of DNA repair may be an important factor and that its importance is dose-dependent. The experimental system will be the human hybrid cell neoplastic transformation assay that we are currently using. We propose to test the following hypothesis: Down-regulation of DNA dsb repair will abrogate the low dose suppression of neoplastic transformation. Using the technique of RNA silencing, it is proposed to test the effect of down-regulation of the two major DNA dsb repair pathways, homologous recombination (HR) and non-homologous end-joining (NHEJ), on the dose response relationship for neoplastic transformation. Based on prior studies, we predict that this will result in abrogation of the suppressive effect at doses in the range 1 to 10 cGy, but not at lower doses. The proposed experiments will also help address the question as to which of the two DNA repair pathways may be the most important in causing suppression of transformation. HR is a pathway that is predominant in S and G2 phase cells and is known to be less error-prone than the NHEJ pathway that is predominant in G1 phase. We hypothesize that down-regulation of HR will result in the most effective abrogation of suppression. An important component of this study will be the determination of the how abrogation of DNA dsb repair impacts the spontaneous transformation frequency, presumably a consequence of endogeneous DNA damage. Experiments will be carried out using partially synchronized populations of cells enriched for G1 and S/G2 respectively. In addition to the endpoint of neoplastic transformation the impact of down-regulation of HR and NHEJ on the formation and disappearance of the DNA dsb marker, gamma-H2AX, will be studied.

  1. Statistical mechanics problem sheet 1 Unstarred problems follow quickly from definitions and equations in the lectures; single

    E-Print Network [OSTI]

    Dettmann, Carl

    as isolated, closed or open, and give a brief expla- nation of your answer: (a) The solar system (b) A tin but not in thermal equilibrium (d) A system not in equilibrium that absorbs heat from a cold system and imparts heat by an isochoric process. (b) An isochoric followed by an isobaric process. (c) An isothermal process. Explain what

  2. Electronic door locking mechanism

    DOE Patents [OSTI]

    Williams, G.L.; Kirby, P.G.

    1997-10-21T23:59:59.000Z

    The invention is a motorized linkage for engaging a thumb piece in a door mechanism. The device has an exterior lock assembly with a small battery cell and combination lock. Proper entry by a user of a security code allows the battery to operate a small motor within the exterior lock assembly. The small motor manipulates a cam-plunger which moves an actuator pin into a thumb piece. The user applies a force on to the thumb piece. This force is transmitted by the thumb piece to a latch engagement mechanism by the actuator pin. The latch engagement mechanism operates the door latch. 6 figs.

  3. Mechanism of Gravity Impulse

    E-Print Network [OSTI]

    Ning Wu

    2005-10-01T23:59:59.000Z

    It is well-known that energy-momentum is the source of gravitational field. For a long time, it is generally believed that only stars with huge masses can generate strong gravitational field. Based on the unified theory of gravitational interactions and electromagnetic interactions, a new mechanism of the generation of gravitational field is studied. According to this mechanism, in some special conditions, electromagnetic energy can be directly converted into gravitational energy, and strong gravitational field can be generated without massive stars. Gravity impulse found in experiments is generated by this mechanism.

  4. Rotary mechanical latch

    DOE Patents [OSTI]

    Spletzer, Barry L.; Martinez, Michael A.; Marron, Lisa C.

    2012-11-13T23:59:59.000Z

    A rotary mechanical latch for positive latching and unlatching of a rotary device with a latchable rotating assembly having a latching gear that can be driven to latched and unlatched states by a drive mechanism such as an electric motor. A cam arm affixed to the latching gear interfaces with leading and trailing latch cams affixed to a flange within the drive mechanism. The interaction of the cam arm with leading and trailing latch cams prevents rotation of the rotating assembly by external forces such as those due to vibration or tampering.

  5. Engineering Endostatin-Producing Cartilaginous Constructs for Cartilage Repair Using Nonviral Transfection of Chondrocyte-Seeded and Mesenchymal-Stem-Cell-Seeded Collagen Scaffolds

    E-Print Network [OSTI]

    Jeng, Lily

    Although there is widespread recognition of the importance of angiogenesis in tissue repair, there is little work on the inhibition of angiogenesis in the context of tissue engineering of naturally avascular tissues, like ...

  6. The dynamic sphere test problem

    SciTech Connect (OSTI)

    Chabaud, Brandon M. [Los Alamos National Laboratory; Brock, Jerry S. [Los Alamos National Laboratory; Smith, Brandon M. [Los Alamos National Laboratory

    2012-05-16T23:59:59.000Z

    In this manuscript we define the dynamic sphere problem as a spherical shell composed of a homogeneous, linearly elastic material. The material exhibits either isotropic or transverse isotropic symmetry. When the problem is formulated in material coordinates, the balance of mass equation is satisfied automatically. Also, the material is assumed to be kept at constant temperature, so the only relevant equation is the equation of motion. The shell has inner radius r{sub i} and outer radius r{sub o}. Initially, the shell is at rest. We assume that the interior of the shell is a void and we apply a time-varying radial stress on the outer surface.

  7. Emerging Trends in Heart Valve Engineering: Part III. Novel Technologies for Mitral Valve Repair and Replacement.

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    of different mechanical prostheses suitable for replacementmechanical cardiac valve prosthesis. Ann. Thorac. Surg. 75:and clinical impact of prosthesis–patient mismatch in the

  8. Disrupted G{sub 1} to S phase clearance via cyclin signaling impairs liver tissue repair in thioacetamide-treated type 1 diabetic rats

    SciTech Connect (OSTI)

    Devi, Sachin S. [Department of Toxicology, School of Pharmacy, College of Health Sciences, University of Louisiana at Monroe, 700 University Avenue, Sugar Hall no. 306, Monroe, LA 71209-0470 (United States); Mehendale, Harihara M. [Department of Toxicology, School of Pharmacy, College of Health Sciences, University of Louisiana at Monroe, 700 University Avenue, Sugar Hall no. 306, Monroe, LA 71209-0470 (United States)]. E-mail: mehendale@ulm.edu

    2005-09-01T23:59:59.000Z

    Previously we reported that a nonlethal dose of thioacetamide (TA, 300 mg/kg) causes 90% mortality in type 1 diabetic (DB) rats because of irreversible acute liver injury owing to inhibited hepatic tissue repair, primarily due to blockage of G{sub 0} to S phase progression of cell division cycle. On the other hand, DB rats receiving 30 mg TA/kg exhibited equal initial liver injury and delayed tissue repair compared to nondiabetic (NDB) rats receiving 300 mg TA/kg, resulting in a delay in recovery from liver injury and survival. The objective of the present study was to test the hypothesis that impaired cyclin-regulated progression of G{sub 1} to S phase of the cell cycle may explain inhibited liver tissue repair, hepatic failure, and death, contrasted with delayed liver tissue repair but survival observed in the DB rats receiving 300 in contrast to 30 mg TA/kg. In the TA-treated NDB rats sustained MAPKs and cyclin expression resulted in higher phosphorylation of retinoblastoma (pRb), explaining prompt tissue repair and survival. In contrast, DB rats receiving the same dose of TA (300 mg/kg) exhibited suppressed MAPKs and cyclin expression that led to inhibition of pRb, inhibited tissue repair, and death. On the other hand, DB rats receiving 30 mg TA/kg exhibited delayed up regulation of MAPK signaling that delayed the expression of CD1 and pRb, explaining delayed stimulation of tissue repair observed in this group. In conclusion, the hepatotoxicant TA has a dose-dependent adverse effect on cyclin-regulated pRb signaling: the lower dose causes a recoverable delay, whereas the higher dose inhibits it with corresponding effect on the ultimate outcomes on hepatic tissue repair; this dose-dependent adverse effect is substantially shifted to the left of the dose response curve in diabetes.

  9. Ultralight, ultrastiff mechanical metamaterials

    E-Print Network [OSTI]

    Zheng, Xiaoyu

    The mechanical properties of ordinary materials degrade substantially with reduced density because their structural elements bend under applied load. We report a class of microarchitected materials that maintain a nearly ...

  10. Mechanical Compression Heat Pumps 

    E-Print Network [OSTI]

    Apaloo, T. L.; Kawamura, K.; Matsuda, J.

    1986-01-01T23:59:59.000Z

    to develop, design and test compressors built to meet the needs of the mechanically demanding industrial heat pump applications which often require high compression ratios and temperatures in excess of 200 degrees F. This paper will review the theoretical...

  11. Renewable Auction Mechanism (RAM)

    Broader source: Energy.gov [DOE]

    The Renewable Auction Mechanism (RAM), approved by the California Public Utilities Commission (CPUC) in December 2010, is expected to result in 1,299 megawatts (MW) of new distributed generation ...

  12. ITERATIVE METHODS FOR NEUTRON TRANSPORT EIGENVALUE PROBLEMS

    E-Print Network [OSTI]

    Graham, Ivan

    Abstract. We discuss iterative methods for computing criticality in nuclear reactors. In general as the inner solver. Key words. neutron transport, criticality, generalised eigenvalue problem, symmetry. Reactor criticality problems. Climate change is a challenging problem of great contemporary interest

  13. Problem Set 3 Let's Simplex

    E-Print Network [OSTI]

    Chen, Yiling

    Problem Set 3 Let's Simplex Applied Mathematics 121 -- Spring 2011 Due 5:00 PM, Friday, February 18 linear programs using the Simplex method. Second, you will get a better understanding of linear programming through a better understanding of the Simplex method. Contents 1 Making it rain 2 2 Simplex

  14. Problem Set 3 Let's Simplex

    E-Print Network [OSTI]

    Chen, Yiling

    Problem Set 3 Let's Simplex AM121/ES121 -- Fall 2014 Due 5:00 PM, Tuesday, September 30, 2014 linear programs using the Simplex method. Second, you will get a better understanding of linear programming through a better understanding of the Simplex method. Contents 1 Making it rain 3 2 Simplex

  15. Problem Set 3 Let's Simplex

    E-Print Network [OSTI]

    Chen, Yiling

    Problem Set 3 Let's Simplex Applied Mathematics 121 -- Spring 2014 Due 5:00 PM, Friday, February 21 practice solving linear programs using the Simplex method. Second, you will get a better understanding of linear programming through a better understanding of the Simplex method. Contents 1 Making it rain 3 2

  16. Problems in unification and supergravity

    SciTech Connect (OSTI)

    Farrar, G.; Henyey, F. (eds.)

    1984-01-01T23:59:59.000Z

    Problems in unification of the various gauge groups, quantum gravity, supersymmetry and supergravity, compact dimensions of space-time, and conditions at the beginning of the universe are discussed. Separate entries were prepared for the data base for the 15 papers presented. (WHK)

  17. Sour landfill gas problem solved

    SciTech Connect (OSTI)

    Nagl, G.; Cantrall, R. [Wheelabrator Clean Air Systems, Inc., Schaumburg, IL (United States)

    1996-05-01T23:59:59.000Z

    In Broward County, Fla., near Pompano Beach, Waste Management of North America (WMNA, a subsidiary of WMX Technologies, Oak Brook, IL) operates the Central Sanitary Landfill and Recycling Center, which includes the country`s largest landfill gas-to-energy plant. The landfill consists of three collection sites: one site is closed, one is currently receiving garbage, and one will open in the future. Approximately 9 million standard cubic feet (scf) per day of landfill gas is collected from approximately 300 wells spread over the 250-acre landfill. With a dramatic increase of sulfur-containing waste coming to a South Florida landfill following Hurricane Andrew, odors related to hydrogen sulfide became a serious problem. However, in a matter of weeks, an innovative desulfurization unit helped calm the landfill operator`s fears. These very high H{sub 2}S concentrations caused severe odor problems in the surrounding residential area, corrosion problems in the compressors, and sulfur dioxide (SO{sub 2}) emission problems in the exhaust gas from the turbine generators.

  18. MATRIXDEPENDENT MULTIGRIDHOMOGENIZATION FOR DIFFUSION PROBLEMS

    E-Print Network [OSTI]

    ­dependent prolongations and the construction of coarse grid operators by means of the Galerkin approximation. In numerical on a micro­scale level, require that all length scales appearing in the problem are completely resolved. In numerical simulation however, due to reasons of storage requirements and numerical complexity

  19. Monte Carlo photon benchmark problems

    SciTech Connect (OSTI)

    Whalen, D.J.; Hollowell, D.E.; Hendricks, J.S.

    1991-01-01T23:59:59.000Z

    Photon benchmark calculations have been performed to validate the MCNP Monte Carlo computer code. These are compared to both the COG Monte Carlo computer code and either experimental or analytic results. The calculated solutions indicate that the Monte Carlo method, and MCNP and COG in particular, can accurately model a wide range of physical problems.

  20. Substation automation problems and possibilities

    SciTech Connect (OSTI)

    Smith, H.L.

    1996-10-01T23:59:59.000Z

    The evolutionary growth in the use and application of microprocessors in substations has brought the industry to the point of considering integrated substation protection, control, and monitoring systems. An integrated system holds the promise of greatly reducing the design, documentation, and implementation cost for the substation control, protection, and monitoring systems. This article examines the technical development path and the present implementation problems.

  1. The Preclose Technique in Percutaneous Endovascular Aortic Repair: A Systematic Literature Review and Meta-analysis

    SciTech Connect (OSTI)

    Jaffan, Abdel Aziz A., E-mail: aajaffan@gmail.com [Emory University School of Medicine, Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology (United States); Prince, Ethan A., E-mail: eprince@lifespan.org [Warren Alpert Medical School of Brown University, Rhode Island Hospital, Section of Vascular and Interventional Radiology, Department of Diagnostic Imaging (United States); Hampson, Christopher O., E-mail: christopherohampson@gmail.com [Mercy Hospital (United States); Murphy, Timothy P., E-mail: tmurphy@lifespan.org [Warren Alpert Medical School of Brown University, Rhode Island Hospital, Section of Vascular and Interventional Radiology, Department of Diagnostic Imaging (United States)

    2013-06-15T23:59:59.000Z

    Purpose. To establish the efficacy and safety of the preclose technique in total percutaneous endovascular aortic repair (PEVAR).MethodsA systematic literature search of Medline database was conducted for series on PEVAR published between January 1999 and January 2012.ResultsThirty-six articles comprising 2,257 patients and 3,606 arterial accesses were included. Anatomical criteria used to exclude patients from undergoing PEVAR were not uniform across all series. The technical success rate was 94 % per arterial access. Failure was unilateral in the majority (93 %) of the 133 failed PEVAR cases. The groin complication rate in PEVAR was 3.6 %; a minority (1.6 %) of these groin complications required open surgery. The groin complication rate in failed PEVAR cases converted to groin cutdown was 6.1 %. A significantly higher technical success rate was achieved when arterial access was performed via ultrasound guidance. Technical failure rate was significantly higher with larger sheath size ({>=}20F). Conclusion. The preclose technique in PEVAR has a high technical success rate and a low groin complication rate. Technical success tends to increase with ultrasound-guided arterial access and decrease with larger access. When failure occurs, it is unilateral in the majority of cases, and conversion to surgical cutdown does not appear to increase the operative risk.

  2. Moment problems and boundaries of number triangles

    E-Print Network [OSTI]

    Gnedin, Alexander

    2008-01-01T23:59:59.000Z

    The boundary problem for graphs like Pascal's but with general multiplicities of edges is related to a `backward' problem of moments of the Hausdorff type.

  3. Relaxations and discretizations for the pooling problem

    E-Print Network [OSTI]

    Akshay Gupte

    2015-04-28T23:59:59.000Z

    Apr 28, 2015 ... Abstract: The pooling problem is a folklore NP-hard global optimization problem that finds appli- cations in industries such as petrochemical ...

  4. photo copy of assignment 1 problems

    E-Print Network [OSTI]

    The problems listed below, and in Exercise 9, are from a Russian Grade 3 textbook.6 Solve the problems and compare their conditions and solutions. a.

  5. Test instances for the traffic assignment problem

    E-Print Network [OSTI]

    2008-01-08T23:59:59.000Z

    Jan 8, 2008 ... mation on test problems previously used in the literature to facilitate benchmarking. Keywords. Traffic assignment problem, BPR function, ...

  6. Asymptotic analysis of an optimal location problem

    E-Print Network [OSTI]

    2003-05-13T23:59:59.000Z

    Asymptotic analysis of an optimal location problem. One considers the problem of optimal location of masses(say production centers) in order to approximate a ...

  7. Jar mechanism accelerator

    SciTech Connect (OSTI)

    Anderson, E.A.; Webb, D.D.

    1989-07-11T23:59:59.000Z

    This patent describes an accelerator for use with a jar mechanism in a well pipe string to enhance the jarring impact delivered to a stuck object wherein the jar mechanism includes inner and outer members for connection, respectively, between the well pipe string the stuck object. The jar mechanism members are constructed to (1) restrict relative longitudinal movement therebetween to build up energy in the well pipe string and accelerator and then (2) to release the jar mechanism members for unrestrained, free relative longitudinal movement therebetween to engage jarring surfaces on the jar mechanism members for delivering a jarring impact to the stuck object. The accelerator includes: inner and outer telescopically connected members relatively movable longitudinally to accumulate energy in the accelerator; the inner and outer accelerator members each having means for connecting the accelerator in the well pipe string; means associated with the inner and outer members for initially accomodating a predetermined minimum length of unrestrained, free relative longitudinal movement between the inner and outer accelerator members.

  8. Urban agriculture as a tool for neighborhood fabric repair in post-industrial Detroit

    E-Print Network [OSTI]

    Fairbank, Sandra Trubow

    2011-01-01T23:59:59.000Z

    This thesis focuses on Detroit as a post-industrial city that suffers from abandonment, vacancy, and food security issues. I address this problem through the lens of agriculture, asking how urban farming can be used to ...

  9. A Computer Generated Reduced Iso-Octane Chemical Kinetic Mechanism Applied to Simulation of HCCI Combustion

    SciTech Connect (OSTI)

    Aceves, S M; Martinez-Frias, J; Flowers, D; Smith, J R; Dibble, R; Chen, J Y

    2002-08-12T23:59:59.000Z

    This paper shows how a computer can systematically remove non-essential chemical reactions from a large chemical kinetic mechanism. The computer removes the reactions based upon a single solution using a detailed mechanism. The resulting reduced chemical mechanism produces similar numerical predictions significantly faster than predictions that use the detailed mechanism. Specifically, a reduced chemical kinetics mechanism for iso-octane has been derived from a detailed mechanism by eliminating unimportant reaction steps and species. The reduced mechanism has been developed for the specific purpose of fast and accurate prediction of ignition timing in an HCCI engine. The reduced mechanism contains 199 species and 383 reactions, while the detailed mechanism contains 859 species and 3606 reactions. Both mechanisms have been used in numerical simulation of HCCI combustion. The simulations show that the reduced mechanism predicts pressure traces and heat release with good accuracy, similar to the accuracy obtained with the detailed mechanism. As may be expected, emissions of hydrocarbon and carbon monoxide are not as well predicted with the reduced mechanism as with the detailed mechanism, since the reduced mechanism was targeted for predicting HCCI ignition and not HC and CO emissions. Considering that the reduced mechanism requires about 25 times less computational time than the detailed mechanism (2 hours vs. 2 days), the ability to automatically generate a problem specific reduced mechanism is an important new tool for combustion research in general.

  10. Liquid measurement - Techniques and problems

    SciTech Connect (OSTI)

    Caffey, B.R.

    1984-04-01T23:59:59.000Z

    This paper reviews a few liquid measurement techniques and their associated problems. In measuring liquid petroleum gas, the first obstacle to overcome is accomodating some form of volumetric measurement. This is usually accomplished by orifice, positive displacement, or turbine meters. Each of the three established methods is covered extensively by industry standards in the API Manual of Petroleum Standards. If the operator follows these standards, very accurate results can be achieved.

  11. Diagnostics for multiple regression problems

    SciTech Connect (OSTI)

    Daly, J.C.

    1982-03-01T23:59:59.000Z

    In the last 10 to 15 years there has been much work done in trying to improve linear regression results. Individuals have analyzed the susceptibility of least-squares results to values far removed from the center of the independent variable observations. They have studied the problem of heavy-tailed residuals, and they have studied the problem of collinearity. From these studies have come ridge regression techniques, robust regression techniques, regression on principal components, etc. However, many practitioners view these methods with suspicion (and ignorance), and prefer to continue using the usual least-squares procedures to fit their models, even though their results might not be answering the question they think. In reaction to this, statisticians are spending more time analyzing how the individual observations affect the least squares results. In the last few years approximately 10 papers and one text have appeared that address the problem of how to study the influence of the individual observations. This report is a study of the recent work done in linear regression diagnostics. It is concerned with analyzing the effect of one case at a time, since the methods to analyze this situation are relatively straight-forward and are not prohibitive computationally.

  12. Beamer graphics problem solved Abhijit Champanerkar

    E-Print Network [OSTI]

    Champanerkar, Abhijit

    Beamer graphics problem solved Abhijit Champanerkar College of Staten Island, CUNY January 15, 2009 Abhijit Champanerkar (CSI, CUNY) Beamer graphics problem solved #12;I wanted to get the following and not on a Mac :( Abhijit Champanerkar (CSI, CUNY) Beamer graphics problem solved #12;Graphics Problem: Figure

  13. Theoretical Modeling of Mechanical-Electrical Coupling of Carbon Nanotubes

    SciTech Connect (OSTI)

    Lu, Jun-Qiang [ORNL; Jiang, Hanqiang [Arizona State University

    2008-01-01T23:59:59.000Z

    Carbon nanotubes have been studied extensively due to their unique properties, ranging from electrical, mechanical, optical, to thermal properties. The coupling between the electrical and mechanical properties of carbon nanotubes has emerged as a new field, which raises both interesting fundamental problems and huge application potentials. In this article, we will review our recently work on the theoretical modeling on mechanical-electrical coupling of carbon nanotubes subject to various loading conditions, including tension/compression, torsion, and squashing. Some related work by other groups will be also mentioned.

  14. The Impact of Individual In Vivo Repair of DNA Double-Strand Breaks on Oral Mucositis in Adjuvant Radiotherapy of Head-and-Neck Cancer

    SciTech Connect (OSTI)

    Fleckenstein, Jochen, E-mail: rajfle@uks.eu [Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg (Germany); Kuehne, Martin; Seegmueller, Katharina; Derschang, Sarah; Melchior, Patrick [Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg (Germany); Graeber, Stefan [Institute for Medical Biometry, Epidemiology und Medical Informatics (IMBEI), Saarland University Medical School, Homburg (Germany); Fricke, Andreas; Ruebe, Claudia E.; Ruebe, Christian [Department of Radiotherapy and Radiation Oncology, Saarland University Medical School, Homburg (Germany)

    2011-12-01T23:59:59.000Z

    Purpose: To evaluate the impact of individual in vivo DNA double-strand break (DSB) repair capacity on the incidence of severe oral mucositis in patients with head-and-neck cancer undergoing adjuvant radiotherapy (RT) or radiochemotherapy (RCT). Patients and Methods: Thirty-one patients with resected head-and-neck cancer undergoing adjuvant RT or RCT were examined. Patients underwent RT of the primary tumor site and locoregional lymph nodes with a total dose of 60-66 Gy (single dose 2 Gy, five fractions per week). Chemotherapy consisted of two cycles of cisplatin and 5-fluorouracil. To assess DSB repair, {gamma}-H2AX foci in blood lymphocytes were quantified before and 0.5 h, 2.5 h, 5 h, and 24 h after in vivo radiation exposure (the first fraction of RT). World Health Organization scores for oral mucositis were documented weekly and correlated with DSB repair. Results: Sixteen patients received RT alone; 15 patients received RCT. In patients who developed Grade {>=} 3 mucositis (n = 18) the amount of unrepaired DSBs 24 h after radiation exposure and DSB repair half-times did not differ significantly from patients with Grade {<=}2 mucositis (n = 13). Patients with a proportion of unrepaired DSBs after 24 h higher than the mean value + one standard deviation had an increased incidence of severe oral mucositis. Conclusions: Evaluation of in vivo DSB repair by determination of {gamma}-H2AX foci loss is feasible in clinical practice and allows identification of patients with impaired DSB repair. The incidence of oral mucositis is not closely correlated with DSB repair under the evaluated conditions.

  15. Identification of Intrinsic Order and Disorder in the DNA Repair Protein XPA

    SciTech Connect (OSTI)

    Iakoucheva, Lilia M.; Kimzey, Amy L.; Masselon, Christophe D.; Bruce, James E.; Garner, Ethan C.; Brown, Celeste J.; Dunker, A. K.; Smith, Richard D.; Ackerman, Eric J.

    2001-03-01T23:59:59.000Z

    The damage recognition protein XPA is required to recognize a wide variety of bulky lesions during nucleotide excision repair (NER). Independent NMR solution structures of a human XPA protein (hXPA) fragment comprising approximately one-third of the full-length protein, the minimal DNA-binding domain (MBD), revealed that ~30% of the molecule was structurally disordered. To better characterize structural features of XPA, we performed time-resolved trypsin proteolysis on active, full-length recombinant Xenopus XPA protein (xXPA). The resulting proteolytic fragments were analyzed by electrospray ionization interface coupled to a Fourier transform ion cyclotron resonance (ESI-FTICR) mass spectrometry, SDS-polyacrylamide gel electrophoresis (PAGE), and selected N-terminal sequence determinations. The mass spectrum of the full-length xXPA was consistent with the predicted sequence, 30922.02 vs. 30922.45 Da; respectively. Moreover, the mass spectrometric data allowed the assignment of multiple xXPA fragments not resolvable by SDS PAGE. Full-length xXPA exhibited aberrant mobility on SDS-PAGE with an apparent MW of ~40 kDa. To test predictions that a Glu-rich region (E70-E76) or other local regions of high charge were responsible for this ~40% aberrant SDS-PAGE mobility, the MW's of partial proteolytic fragments from ~5 to 25 kDa precisely determined by ESI-FTICR MS were correlated with their gel positions. Surprisingly, all tested partial tryptic fragments within this size-range exhibited 10-42% divergence between calculated MW and that estimated by SDS-PAGE, thus indicating the origin of anomalous migration of XPA is not localized. The computer program Predictor of Natural Disordered Regions (PONDR) correctly identified several regions of xXPA either sensitive or resistant to partial proteolysis, thereby indicating that disorder in XPA shares sequence features with other well-characterized intrinsically unstructured proteins.

  16. Program Transformation Mechanics A Classification of Mechanisms for Program Transformation

    E-Print Network [OSTI]

    Utrecht, Universiteit

    Program Transformation Mechanics A Classification of Mechanisms for Program Transformation with a Survey of Existing Transformation Systems Jonne van Wijngaarden Eelco Visser UU-CS-2003-048 Institute Transformation Mechanics A Classification of Mechanisms for Program Transformation with a Survey of Existing

  17. Emerging Trends in Heart Valve Engineering: Part III. Novel Technologies for Mitral Valve Repair and Replacement.

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    of commercial bioprosthetic heart valves. Ann. Thorac. Surg.mechanics of arti?cial heart valves. Clin. Exp. Pharmacol.with the ATS bilea?et valve. J. Heart Valve Dis. 18:445–452,

  18. DNA repair modulates the vulnerability of the developing brain to alkylating agents

    E-Print Network [OSTI]

    Samson, Leona D.

    Neurons of the developing brain are especially vulnerable to environmental agents that damage DNA (i.e., genotoxicants), but the mechanism is poorly understood. The focus of the present study is to demonstrate that DNA ...

  19. Mechanical & Industrial Engineering

    E-Print Network [OSTI]

    Mountziaris, T. J.

    on the PI's current research on energy harvesting nanowires, Li-ion batteries, and PEM fuel cells. In energy nanowires from both modeling and in-situ quantitative microscopy perspectives. In Li-ion battery work, we-ion intercalation into nanowires. The last, electro-mechanical characterization of degraded and fresh electrode

  20. Mechanical engineering Department Seminar

    E-Print Network [OSTI]

    Mechanical engineering Department Seminar Wynter J. Duncanson Department of Aerospace and Ocean Engineering Virginia Tech Smart' Bubbles for Acoustic Contrast in Oil Reservoirs 11:00 AM Friday, 19 April engineering from Boston University. Her doctoral research was devoted to designing surface architectures

  1. Mechanical engineering Department Seminar

    E-Print Network [OSTI]

    Lin, Xi

    -electronics, soft robotics, and bio-integrated systems. Host: Basu #12;, Urbana-Champaign Mechanical Design and Fabrication Techniques for Bio-Electronic Systems 11:00 AM Friday, 7 February 2014 Room 245, 110 Cummington Mall Refreshments served at 10:45 AM Biological systems

  2. Mechanical & Biomedical Engineering

    E-Print Network [OSTI]

    Barrash, Warren

    * Engineering Statistics or Probability and Statistics* 3 ME 380 Kinematics & Machine Dynamics 4 ME, CE, or ENGRMechanical & Biomedical Engineering Department BACHELOR OF SCIENCE IN MECHANICAL ENGINEERING COURSE Differential Equations and Matrix Theory 4 ENGR 245 Introduction to Materials Science & Engineering 3 ENGR 210

  3. Imaging the Antikythera Mechanism

    SciTech Connect (OSTI)

    Malzbender, Tom (Hewlett Packard Laboratories) [Hewlett Packard Laboratories

    2011-01-12T23:59:59.000Z

    In 1900, a party of sponge divers chanced on the wreck of a Roman merchant vessel between Crete and mainland Greece. It was found to contain numerous ancient Greek treasures, among them a mysterious lump of clay that split open to reveal 'mathematical gears' as it dried out. This object is now known as the Antikythera Mechanism, one of the most enlightening artifacts in terms of revealing the advanced nature of ancient Greek science and technology. In 2005 we travelled to the National Archeological Museum in Athens to apply our Reflectance Imaging methods to the mechanism in the hopes of revealing ancient writing on the device. We were successful, and along with the results of Microfocus CT imaging, we are able to decipher 3000 characters compared with the original 800 known. This lead to an understanding that the device was a mechanical, astronomical computer from 150 B.C.E. capable of predicting solar and lunar eclipses along with other celestial events. This talk will overview both the imaging methods as well as what they reveal about the Antikythera Mechanism.

  4. STUDENT HANDBOOK MECHANICAL ENGINEERING

    E-Print Network [OSTI]

    Krstic, Miroslav

    accredited programs) Aerospace and Mechanical Engineering: · An ability to apply knowledge of mathematics-long learning. · A knowledge of contemporary issues. · An ability to use modern engineering techniques, skills, and computing tools necessary for engineering practice. Additionally: Aerospace Engineering · Knowledge of key

  5. Mechanical & Aerospace Engineering

    E-Print Network [OSTI]

    implementation of predictive methods in commercial, numerical codes. Finally, opportunities for students University in 2007. During this time, he has been elected to several leadership positions within the ASME, including as the secretary of the ASME Research Committee on the Mechanics of Jointed Structures, he has

  6. ################### g VM Production Mechanisms

    E-Print Network [OSTI]

    Kai­C. Voss, Bonn University 1 Vector meson production at HERA ############################### ################# ############### ############ #################################### ######################################### ############################ #12; Kai­C. Voss, Bonn University 2 Vector meson production at HERA # ################################################## ############################## ## ####################################### # # ## # ######## ### #### # # #12; Kai­C. Voss, Bonn University 3 Vector meson production at HERA VM Production Mechanisms soft

  7. Department of Mechanical Engineering

    E-Print Network [OSTI]

    Li, Teng

    Department of Mechanical Engineering 2014 Fast Facts Faculty Based on 2013 statistics from Master's Degrees Awarded 45 Doctorate Degrees Awarded Funding Fiscal Year 2013 $20M Total Research for Energetic Concepts Development Center for Environmental Energy Engineering Center for Risk and Reliability

  8. MECHANICAL TEST LAB CAPABILITIES

    E-Print Network [OSTI]

    MECHANICAL TEST LAB CAPABILITIES · Static and cyclic testing (ASTM and non-standard) · Impact drop testing · Slow-cycle fatigue testing · High temperature testing to 2500°F · ASTM/ Boeing/ SACMA standard testing · Ability to design and fabricate non-standard test fixtures and perform non-standard tests

  9. Mechanical & Aerospace Engineering

    E-Print Network [OSTI]

    Reisslein, Martin

    conductivity. Coupled with its low thermal conductivity, polymer thermoelectric composites are attractive and thermoelectric applications. I will show that the thermal conductivity of ultra-thin polymer films can both conductivity and phonon transport mechanisms over the past 2 decades, owing much to the challenging needs

  10. Mechanical and Aerospace Engineering

    E-Print Network [OSTI]

    Integration Specialist in the Smart Grid Technologies and Strategy Division of the California IndependentMechanical and Aerospace Engineering seminar The Challenges of Renewable Energy Integration into the CAISO Grid Abstract I will be presenting who the CAISO is and what we do. We will also discuss where we

  11. Residential Mechanical Precooling

    SciTech Connect (OSTI)

    German, A.; Hoeschele, M.

    2014-12-01T23:59:59.000Z

    This research conducted by the Alliance for Residential Building Innovation team evaluated mechanical air conditioner pre-cooling strategies in homes throughout the United States. EnergyPlus modeling evaluated two homes with different performance characteristics in seven climates. Results are applicable to new construction homes and most existing homes built in the last 10 years, as well as fairly efficient retrofitted homes.

  12. Professor C. N. Yang and Statistical Mechanics

    E-Print Network [OSTI]

    F. Y. Wu

    2010-10-09T23:59:59.000Z

    Professor Chen Ning Yang has made seminal and influential contributions in many different areas in theoretical physics. This talk focuses on his contributions in statistical mechanics, a field in which Professor Yang has held a continual interest for over sixty years. His Master's thesis was on a theory of binary alloys with multi-site interactions, some 30 years before others studied the problem. Likewise, his other works opened the door and led to subsequent developments in many areas of modern day statistical mechanics and mathematical physics. He made seminal contributions in a wide array of topics, ranging from the fundamental theory of phase transitions, the Ising model, Heisenberg spin chains, lattice models, and the Yang-Baxter equation, to the emergence of Yangian in quantum groups. These topics and their ramifications will be discussed in this talk.

  13. Quasivelocities and Optimal Control for Underactuated Mechanical Systems

    E-Print Network [OSTI]

    L. Colombo; D. Martin de Diego

    2010-03-04T23:59:59.000Z

    This paper is concerned with the application of the theory of quasivelocities for optimal control for underactuated mechanical systems. Using this theory, we convert the original problem in a variational second-order lagrangian system subjected to constraints. The equations of motion are geometrically derived using an adaptation of the classical Skinner and Rusk formalism.

  14. Combinatorial Design of Key Distribution Mechanisms for Wireless Sensor Networks

    E-Print Network [OSTI]

    Bystroff, Chris

    Combinatorial Design of Key Distribution Mechanisms for Wireless Sensor Networks Seyit A. C¸amtepe1 of the most challenging security issues in wireless sensor networks where sensor nodes are randomly scattered-chain sizes. 1 Introduction and Problem Definition In this work, we consider a sensor network in which sensor

  15. Combinatorial Design of Key Distribution Mechanisms for Wireless Sensor Networks

    E-Print Network [OSTI]

    Bystroff, Chris

    Combinatorial Design of Key Distribution Mechanisms for Wireless Sensor Networks Seyit A. C� amtepe of the most challenging security issues in wireless sensor networks where sensor nodes are randomly scattered­chain sizes. 1 Introduction and Problem Definition In this work, we consider a sensor network in which sensor

  16. Mechanical and Aerospace Engineering Tempe, Arizona 85287-6106

    E-Print Network [OSTI]

    . The material focuses on the crossflow instability that leads to transition on swept wings and rotating disks. Following a brief overview of instability mechanisms and the crossflow problem, a summary of the important geometries are covered. This historical account and literature survey of the crossflow instability are used

  17. FINITE ELEMENT METHOD IN FLUID MECHANICS & HEAT TRANSFER

    E-Print Network [OSTI]

    Camci, Cengiz

    completed this course should be able to perform quick analysis of small problems using the finite element of Fluid Mechanics and Heat Transfer An Introduction to Finite Element Analysis Using "Galerkin Weak of Euler's Equation in Finite Element Analysis Generalized Form of Euler's Equation in Three Dimensional

  18. Unstable trajectories and the quantum mechanical uncertainty

    SciTech Connect (OSTI)

    Moser, Hans R. [Physics Institute, University of Zuerich, Winterthurerstrasse 190, CH-8057 Zuerich (Switzerland)], E-mail: moser@physik.uzh.ch

    2008-08-15T23:59:59.000Z

    There is still an ongoing discussion about various seemingly contradictory aspects of classical particle motion and its quantum mechanical counterpart. One of the best accepted viewpoints that intend to bridge the gap is the so-called Copenhagen Interpretation. A major issue there is to regard wave functions as probability amplitudes (usually for the position of a particle). However, the literature also reports on approaches that claim a trajectory for any quantum mechanical particle, Bohmian mechanics probably being the most prominent one among these ideas. We introduce a way to calculate trajectories as well, but our crucial ingredient is their well controlled local (thus also momentaneous) degree of instability. By construction, at every moment their unpredictability, i.e., their local separation rates of neighboring trajectories, is governed by the local value of the given modulus square of a wave function. We present extensive numerical simulations of the H and He atom, and for some velocity-related quantities, namely angular momentum and total energy, we inspect their agreement with the values appearing in wave mechanics. Further, we interpret the archetypal double slit interference experiment in the spirit of our findings. We also discuss many-particle problems far beyond He, which guides us to a variety of possible applications.

  19. Application of quantum theory of electrons to the mechanical and thermal properties of metals 

    E-Print Network [OSTI]

    Peng, Hwan-Wu

    The first successful application of quantum mechanics to the problem of metallic cohesion was made by Wigner and Seitz (1938) They appoximated sodium metal by a number of isolated spheres of equal atomic volume and integrated, ...

  20. Fast Communication Mechanisms in Coarse-grained Dynamically Reconfigurable Array Architectures

    E-Print Network [OSTI]

    Starzyk, Janusz A.

    vari- ous problems that stem from access mechanisms, energy conservation, error rate, transmission**, Janusz Starzyk** **Ohio University Electrical and Computer Engineering Athens, OH 45701 USA e perfor- mance and flexibility for different challenging appli- cation areas, e. g. future broadband

  1. A Generalized Coupon Collector Problem

    E-Print Network [OSTI]

    Xu, Weiyu

    2010-01-01T23:59:59.000Z

    This paper provides analysis to a generalized version of the coupon collector problem, in which the collector gets $d$ distinct coupons each run and she chooses the one that she has the least so far. On the asymptotic case when the number of coupons $n$ goes to infinity, we show that on average $\\frac{n\\log n}{d} + \\frac{n}{d}(m-1)\\log\\log{n}+O(mn)$ runs are needed to collect $m$ sets of coupons. An efficient exact algorithm is also developed for any finite case to compute the average needed runs exactly. Numerical examples are provided to verify our theoretical predictions.

  2. Pattern Alteration: Prominent Posture Problems

    E-Print Network [OSTI]

    2006-05-05T23:59:59.000Z

    if the problem is severe. These two techniques can help: you can compare the upper back width and the center back length, lines 5 and 9 of your Personal Measurement Chart, with the corresponding measurements on the pattern; or you can check garments you... to the point where you need the altera- tion (generally approximately 5 inches, or 12.7 cm). Draw a horizontal line across the pattern at a right angle to the lengthwise grainline or the center back. (Note: When measuring, allow for a lowered neckline...

  3. First Passage Problems in Biology

    E-Print Network [OSTI]

    Tom Chou; Maria R. D'Orsogna

    2014-08-20T23:59:59.000Z

    Applications of first passage times in stochastic processes arise across a wide range of length and time scales in biological settings. After an initial technical overview, we survey representative applications and their corresponding models. Within models that are effectively Markovian, we discuss canonical examples of first passage problems spanning applications to molecular dissociation and self-assembly, molecular search, transcription and translation, neuronal spiking, cellular mutation and disease, and organismic evolution and population dynamics. In this last application, a simple model for stem-cell ageing is presented and some results derived. Various approximation methods and the physical and mathematical subtleties that arise in the chosen applications are also discussed.

  4. Mosquito Problems after a Storm

    E-Print Network [OSTI]

    Johnsen, Mark

    2008-08-05T23:59:59.000Z

    ER-042 8-08 Mark M. Johnsen, Texas AgriLife Extension Service, The Texas A&M System After a severe storm, mosquito populations can explode, and the diseases they carry can be a danger to humans. Mosquito problems occur in two distinct waves after.... Louis encephalitis. This mosquito species lays eggs in roadside ditches, storm sew- ers, birdbaths, or any container or depression that holds water. Eggs hatch in 7 days. West Nile virus (WNV) has two distinct clini- cal forms known as West Nile Fever...

  5. Mathematical Problems of Thermoacoustic Tomography

    E-Print Network [OSTI]

    Nguyen, Linh V.

    2010-10-12T23:59:59.000Z

    (y,s) = ?integraldisplay 0 ?R(s,?) ?integraldisplay 0 g(y,r)I(r,?)drd?. The key ingredient in the proof of Theorem A.1 is the following identity, which is equivalent to a range description of operator T (see Remark D.3): Theorem A.4 Suppose that ? is a ball, f ? C?0... . . . . . . . . . . . . . . . . . . . 6 C. Publications and presentations of the results . . . . . . . . 7 II INVERSION FORMULAS . . . . . . . . . . . . . . . . . . . . . 9 A. Introduction to the problem and main results . . . . . . . 9 B. Derivation of Theorem A.1 from Theorem A.4...

  6. Sierra/solid mechanics 4.22 user's guide.

    SciTech Connect (OSTI)

    Thomas, Jesse David

    2011-10-01T23:59:59.000Z

    Sierra/SolidMechanics (Sierra/SM) is a Lagrangian, three-dimensional code for the analysis of solids and structures. It provides capabilities for explicit dynamic and implicit quasistatic and dynamic analyses. The explicit dynamics capabilities allow for the efficient and robust solution of models subjected to large, suddenly applied loads. For implicit problems, Sierra/SM uses a multi-level iterative solver, which enables it to effectively solve problems with large deformations, nonlinear material behavior, and contact. Sierra/SM has a versatile library of continuum and structural elements, and an extensive library of material models. The code is written for parallel computing environments, and it allows for scalable solutions of very large problems for both implicit and explicit analyses. It is built on the SIERRA Framework, which allows for coupling with other SIERRA mechanics codes. This document describes the functionality and input structure for Sierra/SM.

  7. Environmental Assessment and Finding of No Significant Impact: Pond B Dam Repair Project at the Savannah River Site

    SciTech Connect (OSTI)

    N /A

    1999-09-27T23:59:59.000Z

    The Department of Energy (DOE) has prepared an environmental assessment (EA) (DOE/EA-1285) for the proposed repair of the Pond B dam at the Savannah River Site (SRS), located near Aiken, South Carolina. Based on the analyses in the EA, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 (NEPA). Therefore, the preparation of an environmental impact statement (EIS) is not required, and DOE is issuing this Finding of No Significant Impact (FONSI) and Floodplain Statement of Findings.

  8. Metric problems in sub-Riemannian geometry Gromov's dimension approach to the Holder equivalence problem

    E-Print Network [OSTI]

    Pansu, Pierre

    Metric problems in sub-Riemannian geometry Gromov's dimension approach to the H¨older equivalence problem Gromov's cochain approach to the H¨older equivalence problem Rumin's complex Quasisymmetric H¨older-Lipschitz equivalence problem Differential forms and the H¨older equivalence problem P. Pansu September 1st, 2014 P

  9. Mechanical Harvesting of Corn.

    E-Print Network [OSTI]

    Sorenson, J. W. (Jerome Wallace); Smith, H. P. (Harris Pearson)

    1948-01-01T23:59:59.000Z

    - - TEXAS AGRICULTURAL EXPERIMENT STATION R. D. LEWIS, Director ' College Station, Texas BULLETIN 706 OCTOBER 1948 Mechanical Harvesting of Corn H. P. SMITH and J. W. SORENSON, JR. Department of Agricultural Engineering LlBRARY Atricaltr... of corn, from which they harvest about 77 million bushels valued at about 584 million. Most of the corn produced in Texas is harvested by hand. There were approximately 800 corn-picking machines of all types used in Texas in 1947. Texas farmers grow...

  10. WINTERTemplate Geochemical mechanisms of

    E-Print Network [OSTI]

    Borissova, Daniela

    WINTERTemplate 01 Geochemical mechanisms of carbonate equilibria in the system CO2 -H2O-CaCO3 #12 dissolved in soil · Dissolution of CaCO3 · Precipitation of CaCO3 · Physicochemical precipitation (prevention of the CO2 outgassing) #12;07Dissolution of CaCO3 H2CO3 HCO3 - CO3 2- H+ CO3 2- + H+ HCO3 - HCO3

  11. Mechanics of collective unfolding

    E-Print Network [OSTI]

    M Caruel; J. -M Allain; L Truskinovsky

    2015-01-07T23:59:59.000Z

    Mechanically induced unfolding of passive crosslinkers is a fundamental biological phenomenon encountered across the scales from individual macro-molecules to cytoskeletal actin networks. In this paper we study a conceptual model of athermal load-induced unfolding and use a minimalistic setting allowing one to emphasize the role of long-range interactions while maintaining full analytical transparency. Our model can be viewed as a description of a parallel bundle of N bistable units confined between two shared rigid backbones that are loaded through a series spring. We show that the ground states in this model correspond to synchronized, single phase configurations where all individual units are either folded or unfolded. We then study the fine structure of the wiggly energy landscape along the reaction coordinate linking the two coherent states and describing the optimal mechanism of cooperative unfolding. Quite remarkably, our study shows the fundamental difference in the size and structure of the folding-unfolding energy barriers in the hard (fixed displacements) and soft (fixed forces) loading devices which persists in the continuum limit. We argue that both, the synchronization and the non-equivalence of the mechanical responses in hard and soft devices, have their origin in the dominance of long-range interactions. We then apply our minimal model to skeletal muscles where the power-stroke in acto-myosin crossbridges can be interpreted as passive folding. A quantitative analysis of the muscle model shows that the relative rigidity of myosin backbone provides the long-range interaction mechanism allowing the system to effectively synchronize the power-stroke in individual crossbridges even in the presence of thermal fluctuations. In view of the prototypical nature of the proposed model, our general conclusions pertain to a variety of other biological systems where elastic interactions are mediated by effective backbones.

  12. Bile Duct Disruption Following Radiofrequency Ablation: Successful Repair Using a Covered Stent

    SciTech Connect (OSTI)

    Thompson, Philip M.; Hare, Christopher M.B., E-mail: christopher.hare@uclh.org; Lees, William R. [Middlesex Hospital, Department of Radiology (United Kingdom)

    2004-08-15T23:59:59.000Z

    Persistent biliary leaks, whether iatrogenic or secondary to malignancy, often present a difficult management problem. Recent reports have suggested a role for covered metallic stents in this context. We describe the successful use of a covered stent to seal a persistent biliary leak following radiofrequency ablation of colorectal liver metastases.

  13. 16.513 Midterm Exam (Spring 2005) There are 5 problems and one bonus problem.

    E-Print Network [OSTI]

    Hu, Tingshu

    16.513 Midterm Exam (Spring 2005) There are 5 problems and one bonus problem. 1. (15) For eachSSS -= - -= 100 110 110 , 31 20 21 AA #12;6. Bonus problem (20) : Given a state equation Bu

  14. Multiple Vehicle Routing Problem with Fuel Constraints

    E-Print Network [OSTI]

    Levy, David

    2013-06-26T23:59:59.000Z

    In this paper, a Multiple Vehicle Routing Problem with Fuel Constraints (MVRPFC) is considered. This problem consists of a field of targets to be visited, and a collection of vehicles with fuel tanks that may visit the targets. Consideration...

  15. Characteristics of problem solving success in physics 

    E-Print Network [OSTI]

    Wallace, Marsali Beth

    2014-06-28T23:59:59.000Z

    Skills in problem solving, including finding and applying the appropriate knowledge to a problem, are important learning outcomes from the completion of a Physics degree at University. This thesis investigates the ...

  16. Computational evaluation of two reactor benchmark problems

    E-Print Network [OSTI]

    Cowan, James Anthony

    1998-01-01T23:59:59.000Z

    macroscopic cross sections for various pincell models in each benchmark problem. DEF3D, a multigroup multidimensional diffusion code, was used to evaluate the uranium-fueled lattice benchmark problem of the American Nuclear Society. TWODANT, a multigroup, two...

  17. Multiple Vehicle Routing Problem with Fuel Constraints 

    E-Print Network [OSTI]

    Levy, David

    2013-06-26T23:59:59.000Z

    In this paper, a Multiple Vehicle Routing Problem with Fuel Constraints (MVRPFC) is considered. This problem consists of a field of targets to be visited, and a collection of vehicles with fuel tanks that may visit the targets. Consideration...

  18. A system analysis of the spam problem

    E-Print Network [OSTI]

    Weinberg, Gabriel R. (Gabriel Reiter)

    2005-01-01T23:59:59.000Z

    This thesis considers the problem of the large amount of unwanted email that is being sent and received, which lowers the aggregate value of email as a communication medium from what it would otherwise be. This problem is ...

  19. The Multi-Network Design Problem

    E-Print Network [OSTI]

    Balakrishnan, Anantaram

    This paper studies a new multi-facility network synthesis problem, called the Multi-level Network Design (MLND) problem, that arises in the topological design of hierarchical communication, transportation, and electric ...

  20. Some Problems in Stochastic Portfolio Theory

    E-Print Network [OSTI]

    Liu, Xiaobo

    2007-12-11T23:59:59.000Z

    We consider some problems in the stochastic portfolio theory of equity markets. In the first part, we maximize the expected terminal value of a portfolio of equities. The optimal investment problem is then solved by the stochastic control approach...

  1. Nonparametric Bayesian analysis of some clustering problems

    E-Print Network [OSTI]

    Ray, Shubhankar

    2006-10-30T23:59:59.000Z

    it useful for clustering problems where the number of clusters is unknown. We develop nonparametric Bayesian models for two different clustering problems, namely functional and graphical clustering. We propose a nonparametric Bayes wavelet model...

  2. The 3He Supply Problem

    SciTech Connect (OSTI)

    Kouzes, Richard T.

    2009-05-01T23:59:59.000Z

    One of the main uses for 3He is in gas proportional counters for neutron detection. Radiation portal monitors deployed for homeland security and non-proliferation use such detectors. Other uses of 3He are for research detectors, commercial instruments, well logging detectors, dilution refrigerators, for targets or cooling in nuclear research, and for basic research in condensed matter physics. The US supply of 3He comes almost entirely from the decay of tritium used in nuclear weapons by the US and Russia. A few other countries contribute a small amount to the world’s 3He supply. Due to the large increase in use of 3He for homeland security, the supply has dwindled, and can no longer meet the demand. This white paper reviews the problems of supply, utilization, and alternatives.

  3. Quantum simulations of physics problems

    SciTech Connect (OSTI)

    Somma, R. D. (Rolando D.); Ortiz, G. (Gerardo); Knill, E. H. (Emanuel H.); Gubernatis, J. E.

    2003-01-01T23:59:59.000Z

    If a large Quantum Computer (QC) existed today, what type of physical problems could we efficiently simulate on it that we could not efficiently simulate on a classical Turing machine? In this paper we argue that a QC could solve some relevant physical 'questions' more efficiently. The existence of one-to-one mappings between different algebras of observables or between different Hilbert spaces allow us to represent and imitate any physical system by any other one (e.g., a bosonic system by a spin-1/2 system). We explain how these mappings can be performed, and we show quantum networks useful for the efficient evaluation of some physical properties, such as correlation functions and energy spectra.

  4. Quantum geometrodynamics creates new problems

    E-Print Network [OSTI]

    T. P. Shestakova

    2008-10-22T23:59:59.000Z

    The development of last years in quantum geometrodynamics highlights new problems which were not obvious in its first formulation proposed by Wheeler and DeWitt. At the first stage the main task was to apply known quantization schemes to gravitational field or a certain cosmological model. This way has led to the realization of the fact that a quantum description of the Universe is impossible without implicit or explicit indication to a reference frame presented by some medium, filling the whole Universe, with its own equation of state and thermodynamical properties. Thus the questions arise, should one seek for a "privileged" reference frame or consider all the variety of gauge conditions and appropriate solutions for the wave function? It is worth noting that thermodynamical properties of such a quantum Universe would also depend on a chosen reference frame to some extent. So, we need a self-consistent quantum theoretical and thermodynamical description of the Universe.

  5. Oxygen Tension Modulates Neurite Outgrowth in PC12 Cells Through A Mechanism Involving HIF and VEGF

    E-Print Network [OSTI]

    Genetos, Damian C.; Cheung, Whitney K.; Decaris, Martin L.; Leach, J. Kent

    2010-01-01T23:59:59.000Z

    neural repair. Keywords Oxygen tension . Neurite extension .respective physiological oxygen microenvironments (Chen etet al. 2008). For example, oxygen tension differentially

  6. ENGINEERING MECHANICS SEMINARSENGINEERING MECHANICS SEMINARS BIO COMPOSITES FOR AVIATION

    E-Print Network [OSTI]

    Ponce, V. Miguel

    carbon composite general aviation aircraft); and Manager of Materials and Structures Research at Sikorsky temperature and bio material composite programs. In bio composite material programs Ron frequently worksENGINEERING MECHANICS SEMINARSENGINEERING MECHANICS SEMINARS BIO COMPOSITES FOR AVIATION Ron

  7. MECHANICAL ENGINEERING Both faculty and students in mechanical engineering at

    E-Print Network [OSTI]

    Gelfond, Michael

    MECHANICAL ENGINEERING RESEARCH Both faculty and students in mechanical engineering at Texas Tech work on a variety of research projects including heat transfer, combustion, and energetic materials analysis; human- centric design research; control science and engineering; computational fluid dynamics

  8. Optimization Online - Equivalence of Convex Problem Geometry ...

    E-Print Network [OSTI]

    Robert Freund

    2009-02-07T23:59:59.000Z

    Feb 7, 2009 ... Equivalence of Convex Problem Geometry and Computational Complexity in the Separation Oracle Model. Robert Freund (rfreund ***at*** ...

  9. The Monty Hall Problem Richard D. Gill

    E-Print Network [OSTI]

    Gill, Richard D.

    the Monty Hall problem is often called the Monty Hall para- dox. The key to accepting and understanding

  10. RADIATION SENSITIVITY & PROCESSING OF DNA DAMAGE FOLLOWING LOW DOSES OF GAMMA-RAY ALPHA PARTICLES & HZE IRRADIATION OF NORMAL DSB REPAIR DEFICIENT CELLS

    SciTech Connect (OSTI)

    O'Neil, Peter

    2009-05-15T23:59:59.000Z

    Non-homologous end joining (NHEJ) predominates in the repair of DNA double strand breaks (DSB) over homologous recombination (HR). NHEJ occurs throughout the cell cycle whereas HR occurs in late S/G2 due to the requirement of a sister chromatid (Rothkamm et al, Mol Cell Biol 23 5706-15 [2003]). To date evidence obtained with DSB repair deficient cells using pulsed-field gel electrophoresis has revealed the major pathway throughout all phases of the cell cycle for processing high dose induced DSBs is NHEJ (Wang et al, Oncogene 20 2212-24 (2001); Pluth et al, Cancer Res. 61 2649-55 [2001]). These findings however were obtained at high doses when on average >> 20-30 DSBs are formed per cell. The contribution of the repair pathways (NHEJ and HR) induced in response to DNA damage during the various phases of the cell cycle may depend upon the dose (the level of initial DSBs) especially since low levels of DSBs are induced at low dose. To date, low dose studies using NHEJ and HR deficient mutants have not been carried out to address this important question with radiations of different quality. The work presented here leads us to suggest that HR plays a relatively minor role in the repair of radiation-induced prompt DSBs. SSBs lead to the induction of DSBs which are associated specifically with S-phase cells consistent with the idea that they are formed at stalled replication forks in which HR plays a major role in repair. That DNA-PKcs is in some way involved in the repair of the precursors to replication-induced DSB remains an open question. Persistent non-DSB oxidative damage also leads to an increase in RAD51 positive DSBs. Both simple and complex non-DSB DNA damage may therefore contribute to indirect DSBs induced by ionising radiation at replication forks.

  11. Einfuhrung Matroid-Probleme in Graphen

    E-Print Network [OSTI]

    Baumann, Tobias

    Einf¨uhrung Matroid-Probleme in Graphen Graphen-Algorithmen Matroide und Greedy-Algorithmen Dr. Tobias Baumann 14. Juni 2011 Dr. Tobias Baumann Matroide #12;Einf¨uhrung Matroid-Probleme in Graphen MST. Tobias Baumann Matroide #12;Einf¨uhrung Matroid-Probleme in Graphen MST Matroide Greedy-Algorithmen Wir

  12. COSMOLOGICAL LITHIUM PROBLEM: A DIFFERENT APPROACH

    E-Print Network [OSTI]

    ?umer, Slobodan

    LITHIUM 7Li sources BBN cosmic-ray interactions (ingredients: shock waves, magnetic field, chargedCOSMOLOGICAL LITHIUM PROBLEM: A DIFFERENT APPROACH Tijana Prodanovi, University of Novi Sad Tamara Observations - boxes 4He ­ OK D ­ right on! 7Li ­ problem! Factor of 3-4 discrepancy! LITHIUM PROBLEM

  13. The Polymatroid Steiner Problems G. Calinescu1

    E-Print Network [OSTI]

    Zelikovsky, Alexander

    sensors capable of monitoring all targets and t is time during which T is used. A simple energy model. #12;2 G. Calinescu and A. Zelikovsky Target-monitoring sensor network lifetime problem. Find problem which is dual to the target-monitoring sensor network lifetime problem. Target-monitoring sensor

  14. Secret Santa, Generalized (and Some Enumerative Problems)

    E-Print Network [OSTI]

    Donnelly, Rob

    Secret Santa, Generalized (and Some Enumerative Problems) Rob Donnelly May 17, 2006 #12;Secret Santa, Generalized May 17, 2006 The Original Secret Santa Problem The Original Secret Santa Problem/she takes A mathematical interpretation of Secret Santa The question essentially asks for the pro- portion

  15. Genome-Wide Identification and 3D Modeling of Proteins involved in DNA Damage Recognition and Repair (Final Report)

    SciTech Connect (OSTI)

    Ruben A. Abagyan, PhD

    2004-04-15T23:59:59.000Z

    OAK-B135 DNA Damage Recognition and Repair (DDR and R) proteins play a critical role in cellular responses to low-dose radiation and are associated with cancer. the authors have performed a systematic, genome-wide computational analysis of genomic data for human genes involved in the DDR and R process. The significant achievements of this project include: (1) Construction of the computational pipeline for searching DDR and R genes, building and validation of 3D models of proteins involved in DDR and R; (2) Functional and structural annotation of the 3D models and generation of comprehensive lists of suggested knock-out mutations; (3) Important improvement of macromolecular docking technology and its application to predict the DNA-Protein complex conformation; (4) Development of a new algorithm for improved analysis of high-density oligonucleotide arrays for gene expression profiling; (5) Construction and maintenance of the DNA Damage Recognition and Repair Database; and (6) Producing 14 research papers (10 published and 4 in preparation).

  16. Treating Time Travel Quantum Mechanically

    E-Print Network [OSTI]

    John-Mark A. Allen

    2014-10-10T23:59:59.000Z

    The fact that closed timelike curves (CTCs) are permitted by general relativity raises the question as to how quantum systems behave when time travel to the past occurs. Research into answering this question by utilising the quantum circuit formalism has given rise to two theories: Deutschian-CTCs (D-CTCs) and "postselected" CTCs (P-CTCs). In this paper the quantum circuit approach is thoroughly reviewed, and the strengths and shortcomings of D-CTCs and P-CTCs are presented in view of their non-linearity and time travel paradoxes. In particular, the "equivalent circuit model"---which aims to make equivalent predictions to D-CTCs, while avoiding some of the difficulties of the original theory---is shown to contain errors. The discussion of D-CTCs and P-CTCs is used to motivate an analysis of the features one might require of a theory of quantum time travel, following which two overlapping classes of new theories are identified. One such theory, the theory of "transition probability" CTCs (T-CTCs), is fully developed. The theory of T-CTCs is shown not to have certain undesirable features---such as time travel paradoxes, the ability to distinguish non-orthogonal states with certainty, and the ability to clone or delete arbitrary pure states---that are present with D-CTCs and P-CTCs. The problems with non-linear extensions to quantum mechanics are discussed in relation to the interpretation of these theories, and the physical motivations of all three theories are discussed and compared.

  17. Quantum mechanical Carnot engine

    E-Print Network [OSTI]

    Bender, C M; Meister, B K

    2000-01-01T23:59:59.000Z

    A cyclic thermodynamic heat engine runs most efficiently if it is reversible. Carnot constructed such a reversible heat engine by combining adiabatic and isothermal processes for a system containing an ideal gas. Here, we present an example of a cyclic engine based on a single quantum-mechanical particle confined to a potential well. The efficiency of this engine is shown to equal the Carnot efficiency because quantum dynamics is reversible. The quantum heat engine has a cycle consisting of adiabatic and isothermal quantum processes that are close analogues of the corresponding classical processes.

  18. Quantum mechanical Carnot engine

    E-Print Network [OSTI]

    C. M. Bender; D. C. Brody; B. K. Meister

    2000-07-03T23:59:59.000Z

    A cyclic thermodynamic heat engine runs most efficiently if it is reversible. Carnot constructed such a reversible heat engine by combining adiabatic and isothermal processes for a system containing an ideal gas. Here, we present an example of a cyclic engine based on a single quantum-mechanical particle confined to a potential well. The efficiency of this engine is shown to equal the Carnot efficiency because quantum dynamics is reversible. The quantum heat engine has a cycle consisting of adiabatic and isothermal quantum processes that are close analogues of the corresponding classical processes.

  19. Efficiency of stripping mechanisms

    E-Print Network [OSTI]

    F. Combes

    2003-08-18T23:59:59.000Z

    There are several physical processes to remove gas from galaxies in clusters, with subsequent starvation and star formation quenching: tidal interactions between galaxies, or tidal stripping from the cluster potential itself, interactions with the hot intra-cluster medium (ICM) through ram pressure, turbulent or viscous stripping, or also outflows from star formation of nuclear activity, We review the observational evidence for all processes, and numerical simulations of galaxies in clusters which support the respective mechanisms. This allows to compare their relative efficiencies, all along cluster formation.

  20. WELL-POSEDNESS OF A THERMO-MECHANICAL MODEL FOR SHAPE MEMORY ALLOYS UNDER TENSION

    E-Print Network [OSTI]

    Stefanelli, Ulisse

    WELL-POSEDNESS OF A THERMO-MECHANICAL MODEL FOR SHAPE MEMORY ALLOYS UNDER TENSION PAVEL KREJC´I AND ULISSE STEFANELLI Abstract. We present a model of the full thermo-mechanical evolution of a shape memory on a time-discretization of the problem are provided. 1. Introduction Shape memory alloys (SMAs) belong

  1. The Importance of the Entropy Inequality on Numerical Simulations Using Reduced Methane-air Reaction Mechanisms

    E-Print Network [OSTI]

    Jones, Nathan

    2012-10-19T23:59:59.000Z

    mechanisms is to reduce the computational time needed to simulate a problem. The focus of this work is on the validity of reduced methane-air combustion mechanisms, particularly pertaining to satisfying the entropy inequality. While much of this work involves...

  2. An application of Laplace transforms to a machine maintenance problem 

    E-Print Network [OSTI]

    Boone, James Robert

    1962-01-01T23:59:59.000Z

    (h) = 0. Considering m independently operating machines in the system, it is convenient to associate with this system m+ 1 states: 0, 0, 0 0 0 . The system is considered to be state 0 if n machines are not operative, m' n hence m-n machines... are operative. This is a system of. independently operating machines which are repaired without queueing, then, the system may be in state 0 at time n t + h in the following four mutually exclusive ways: (1) The state 0 can exist at time t with no repair...

  3. Many Californians with Asthma Have Problems Understanding Their Doctor

    E-Print Network [OSTI]

    Babey, Susan H.; Meng, Ying-Ying; Jones, Malia

    2009-01-01T23:59:59.000Z

    Management Plan Problems Understanding Doctor No Problems Source: 2005 California Health Interview Survey

  4. Problem of Time: Facets and Machian Strategy

    E-Print Network [OSTI]

    Edward Anderson

    2014-07-15T23:59:59.000Z

    The Problem of Time is that `time' in each of ordinary quantum theory and general relativity are mutually incompatible notions. This causes difficulties in trying to put these two theories together to form a theory of Quantum Gravity. The Problem of Time has 8 facets in canonical approaches. I clarify that all but one of these facets already occur at the classical level, and reconceptualize and re-name some of these facets as follows.The Frozen Formalism Problem becomes Temporal Relationalism, the Thin Sandwich Problem becomes Configurational Relationalism, via the notion of Best Matching. The Problem of Observables becomes the Problem of Beables, and the Functional Evolution Problem becomes the Constraint Closure Problem. I also outline how each of the Global and Multiple-Choice Problems of Time have their own plurality of facets. This article additionally contains a local resolution to the Problem of Time at the conceptual level and which is actually realizable for the relational triangle and minisuperspace models. This resolution is, moreover, Machian, and has three levels: classical, semiclassical and a combined semiclassical-histories-timeless records scheme. I end by delineating the current frontiers of this program toward resolution of the Problem of Time in the cases of full GR and of slightly inhomogeneous cosmology.

  5. International Journal of Mechanical Sciences 44 (2002) 451464 Transient solution of a thermoelastic instability problem

    E-Print Network [OSTI]

    Barber, James R.

    several terms requires that the transient behaviour be generated by a sequence of operations in which, these solutions all assume that the sliding speed is constant, whereas actual brakes and clutches operate at variable sliding speed. The speed may be above critical at initial engagement, but dangerously high

  6. Statistical mechanics problem sheet 2 1. Sketch a Carnot cycle in (S, T) space.

    E-Print Network [OSTI]

    Dettmann, Carl

    of volume and heat capacity of liquid water with temperature. 13. Write down the Maxwell relation obtained. In this question, assume that water has constant heat capacity Cp/M = 4.184kJK-1 kg-1 and zero thermal expansion) + S(E2) 2 4. A star is said to have negative heat capacity, that is, increasing the energy (eg

  7. An efficient evolutionary algorithm for solving incrementally structured problems

    E-Print Network [OSTI]

    Ansel, Jason Andrew

    Many real world problems have a structure where small problem instances are embedded within large problem instances, or where solution quality for large problem instances is loosely correlated to that of small problem ...

  8. Exploiting mechanical biomarkers in microfluidics

    E-Print Network [OSTI]

    Exploiting mechanical biomarkers in microfluidics Xiaole Maoa and Tony Jun Huang*b DOI: 10.1039/c2 mechanical biomarkers in microfluidic devices. This trend makes sense because microfluidic devices often of mechanical biomarker- based microfluidic applications. We believe that these examples are just the tip

  9. Mechanical engineering COLLEGE of ENGINEERING

    E-Print Network [OSTI]

    Berdichevsky, Victor

    . Mechanical engineering is a broad, versatile and creative discipline concerned with conversion of energyMechanical engineering COLLEGE of ENGINEERING DepartmentofMechanicalEngineering CollegeofEngineering t Home to nation's first electric-drive vehicle engineering program and alternative energy technology

  10. Mechanical Engineering "The Lindbergh Lectures"

    E-Print Network [OSTI]

    Wisconsin at Madison, University of

    Mechanical Engineering Department "The Lindbergh Lectures" Thursday, November 20, 2014 12:00 ­ 12:50 PM Room 1106 Mechanical Engineering Building "Good Enough" Rapid Compression Machine Experiments Presented by: Dr. Casey Allen Assistant Professor at Mechanical Engineering, Marquette University Abstract

  11. Repair and retrofit of a modern high-rise curtain wall

    SciTech Connect (OSTI)

    Weinstein, J.S.; Del Rosso, A.L.

    1999-07-01T23:59:59.000Z

    Study has revealed that metal and glass exterior curtain walls constructed between the late 1960's and early 1980's can perform poorly and become very ineffective in preventing water infiltration. One such high-rise commercial office building demonstrates that wall performance against water infiltration is compromised due to cyclic wind loads, poor performance of gaskets and sealed joints and poor performance of fasteners and welds used to connect aluminum wall components. Failures and restoration methods at sealant joints and mechanical connections of the curtain wall are illustrated at eight major joint conditions. Methods and approaches used to restore weather resistance and structural integrity are discussed. Use of structural and non-structural silicone sealants as well as unique methods of mechanical anchorage are highlighted. Criteria driving the restoration design are presented, including: minimal disturbance to tenants, no disturbance of asbestos materials, a pleasing visual solution and providing for future long-term wall performance.

  12. PEBBLES Mechanics Simulation Speedup

    SciTech Connect (OSTI)

    Joshua J. Cogliati; Abderrafi M. Ougouag

    2010-05-01T23:59:59.000Z

    Pebble bed reactors contain large numbers of spherical fuel elements arranged randomly. Determining the motion and location of these fuel elements is required for calculating certain parameters of pebble bed reactor operation. These simulations involve hundreds of thousands of pebbles and involve determining the entire core motion as pebbles are recirculated. Single processor algorithms for this are insufficient since they would take decades to centuries of wall-clock time. This paper describes the process of parallelizing and speeding up the PEBBLES pebble mechanics simulation code. Both shared memory programming with the Open Multi-Processing API and distributed memory programming with the Message Passing Interface API are used in simultaneously in this process. A new shared memory lock-less linear time collision detection algorithm is described. This method allows faster detection of pebbles in contact than generic methods. These combine to make full recirculations on AVR sized reactors possible in months of wall clock time.

  13. Mechanics of Isolated Horizons

    E-Print Network [OSTI]

    Abhay Ashtekar; Christopher Beetle; Stephen Fairhurst

    1999-11-04T23:59:59.000Z

    A set of boundary conditions defining an undistorted, non-rotating isolated horizon are specified in general relativity. A space-time representing a black hole which is itself in equilibrium but whose exterior contains radiation admits such a horizon. However, the definition is applicable in a more general context, such as cosmological horizons. Physically motivated, (quasi-)local definitions of the mass and surface gravity of an isolated horizon are introduced and their properties analyzed. Although their definitions do not refer to infinity, these quantities assume their standard values in the static black hole solutions. Finally, using these definitions, the zeroth and first laws of black hole mechanics are established for isolated horizons.

  14. Mechanisms of chemical phototoxicity

    SciTech Connect (OSTI)

    Yurkow, E.J.

    1989-01-01T23:59:59.000Z

    Psoralens in combination with ultraviolet light (PUVA) are phototoxic and potent modulators of epidermal cell growth and differentiation. Using an in vitro cell culture model, the effects of psoralens and UVA light on the growth of epidermal cells were investigated. It was found that psoralen and UVA light interact synergistically to inhibit the growth of cells in culture. This synergism was also observed in the ability of PUVA to inhibit DNA synthesis, decrease cell survival, cause mutations and form psoralen-DNA adducts. Using a cell culture model for the differentiation of melanocytes, PUVA was also found to be a potent inducer of melanogenesis as evidenced by its ability to increase cellular tyrosinase, the enzyme responsible for melanin biosynthesis. Results from these studies indicate that PUVA can induce dramatic alterations in the growth rate and differentiation state of cells at dosage levels which are associated with minimal DNA damage. These findings are in conflict with the general assumption that the biological effects of psoralens and UVA light are associated with their ability to bind covalently to and cross-link DNA. Therefore, the author investigated the possibility that sites of action, other than DNA, are involved in the mechanism(s) by which photoactivated psoralens modulate epidermal cell growth and differentiation. The author's laboratory has found that mammalian epidermal cells contain specific, saturable, high-affinity binding sites for the psoralens that are distinct from DNA. This receptor for the psoralens, photolabeled with ({sup 3}H)-8-methoxysporalen, was visualized following sodium dodecyl sulfatepolyacrylamide gel electrophoresis. The psoralen receptor is shown to be a 22,000 dalton protein located in nonnuclear fractions of cell extracts.

  15. Mechanical contact by constraints and split-based preconditioning

    SciTech Connect (OSTI)

    Dmitry Karpeyev; Derek Gaston; Jason Hales; Steven Novascone

    2014-03-01T23:59:59.000Z

    An accurate implementation of glued mechanical contact was developed in MOOSE based on its Constraint system. This approach results in a superior convergence of elastic structure problems, in particular in BISON. Adaptation of this technique to frictionless and frictional contact models is under way. Additionally, the improved convergence of elastic problems results from the application of the split-based preconditioners to constraint-based systems. This yields a substantial increase in the robustness of elastic solvers when the number of nodes in contact is increased and/or the mesh is refined.

  16. Constrained Graph Optimization: Interdiction and Preservation Problems

    SciTech Connect (OSTI)

    Schild, Aaron V [Los Alamos National Laboratory

    2012-07-30T23:59:59.000Z

    The maximum flow, shortest path, and maximum matching problems are a set of basic graph problems that are critical in theoretical computer science and applications. Constrained graph optimization, a variation of these basic graph problems involving modification of the underlying graph, is equally important but sometimes significantly harder. In particular, one can explore these optimization problems with additional cost constraints. In the preservation case, the optimizer has a budget to preserve vertices or edges of a graph, preventing them from being deleted. The optimizer wants to find the best set of preserved edges/vertices in which the cost constraints are satisfied and the basic graph problems are optimized. For example, in shortest path preservation, the optimizer wants to find a set of edges/vertices within which the shortest path between two predetermined points is smallest. In interdiction problems, one deletes vertices or edges from the graph with a particular cost in order to impede the basic graph problems as much as possible (for example, delete edges/vertices to maximize the shortest path between two predetermined vertices). Applications of preservation problems include optimal road maintenance, power grid maintenance, and job scheduling, while interdiction problems are related to drug trafficking prevention, network stability assessment, and counterterrorism. Computational hardness results are presented, along with heuristic methods for approximating solutions to the matching interdiction problem. Also, efficient algorithms are presented for special cases of graphs, including on planar graphs. The graphs in many of the listed applications are planar, so these algorithms have important practical implications.

  17. Grid Cells: The Position Code, Neural Network Models of Activity, and the Problem of Learning

    E-Print Network [OSTI]

    Fiete, Ila

    COMMENTARY Grid Cells: The Position Code, Neural Network Models of Activity, and the Problem on the modeling and theoretical fronts in the quest to unravel the computational properties of the grid cell code and to explain the mechanisms underlying grid cell dynamics. The goals of the review are to outline a coherent

  18. An approach to the problem of network synthesis utilizing normal coordinates

    E-Print Network [OSTI]

    Baird, Jack Anthony

    1952-01-01T23:59:59.000Z

    AN APPROACH TO THE PROBLEM OF NETWORK SYNTHESIS UTILIZING NORMAL COORDINATES A NPRROCHTHPEB LM FTWK ABHSEBM LTPCY Approved as to style and content by: A N P u __________IUSTPCZBTB of Commit teNETWORK SYNTHESIS UTILIZING NORMAL COORDINATES LM Jack Anthony Baird u * A Dissertation Submitted to the Graduate School of the Agricultural and Mechanical College of Texas In partial fulfillment...

  19. Exemption from Application of the Service Contract Act -Certification UT-B Contracts Div Maintenance, Calibration, or Repair of Certain Equipment

    E-Print Network [OSTI]

    Pennycook, Steve

    Exemption from Application of the Service Contract Act - Certification UT-B Contracts Div-sca-equip-certification-ext-venx-mar09.doc EXEMPTION FROM APPLICATION OF THE SERVICE CONTRACT ACT ­ MAINTENANCE, CALIBRATION, OR REPAIR to the conditions in paragraph (a) of this provision, and the Company determines that the Service Contract Act ­ (1

  20. Exemption from Application of the Service Contract Act -Requirements UT-B Contracts Div Maintenance, Calibration, or Repair of Certain Equipment

    E-Print Network [OSTI]

    Pennycook, Steve

    Exemption from Application of the Service Contract Act - Requirements UT-B Contracts Div-sca-equip-requirement-ext-jan08.doc EXEMPTION FROM APPLICATION OF THE SERVICE CONTRACT ACT ­ MAINTENANCE, CALIBRATION, OR REPAIR inapplicable, and the Agreement shall become subject to the Service Contract Act. In such case, the procedures