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We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Development and Application of a Habitat Suitability Ranking Model for the New Mexico Meadow Jumping Mouse (Zapus hudsonius luteus)  

SciTech Connect (OSTI)

The New Mexico meadow jumping mouse (Zapus hudsonius luteus) is currently listed as a state threatened species in New Mexico and has been identified as potentially occurring within the Los Alamos National Laboratory (LANL) boundary. We describe the development of a model to identify and rank habitat at LANL that may be suitable for occupation by this species. The model calculates a habitat suitability ranking (HSR) based on total plant cover, plant species composition, total number of plant species, and plant height. Input data for the model is based on the measurement of these variables at known locations where this species has been found within the Jemez Mountains. Model development included the selection of habitat variables, developing a probability distribution for each variable, and applying weights to each variable based on their overall importance in defining the suitability of the habitat. The habitat variables (HV) include plant cover (HV1), grass/forb cover (HV2), plant height (HV3), number of forbs (HV4), number of grasses (HV5), and sedge/rush cover (HV6). Once the HVs were selected, probability values were calculated for each. Each variable was then assigned a ''weighting factor'' to reflect the variables' importance relative to one another with respect to contribution to quality of habitat. The least important variable, sedge/rush cover, was assigned a weight factor of ''1'' with increasing values assigned to each remaining variable as follows: number of forbs = 3, number of grasses = 3, plant height = 5, grass/forb cover = 6, and total plant cover = 7. Based on the probability values and weighting factors, a HSR is calculated as follows: HSR = (P{sub HV1}(7) + P{sub HV2}(6) + P{sub HV3}(5) + P{sub HV4}(3) + P{sub HV5}(3) + P{sub HV6}(1)). Once calculated, the HSR values are placed into one of four habitat categorical groupings by which management strategies are applied.

James Biggs; Mary Mullen; Kathryn Bennett

1999-11-01T23:59:59.000Z

2

New Meadows Biomass Facility | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy ResourcesLoading map...(Utility Company) Jump to: navigation, searchOhio:MO) Jump to: navigation,Meadows

3

Meadow Creek | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 No revision hasInformation Earth's Heat JumpIncMAKGalwayHydrothermalMcFarland is a cityMcleod 88 GeothermalMeadow

4

Meadow Lake III | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 No revision hasInformation Earth's Heat JumpIncMAKGalwayHydrothermalMcFarland is a cityMcleod 88II Jump to:Meadow

5

Caribbean House Nicole Meadows  

E-Print Network [OSTI]

1 Caribbean House Nicole Meadows OVERVIEW The Caribbean House is a program that will educate UVM students and the community around them on the different cultures within the Caribbean. Throughout that embodies the Caribbean. This program welcomes all individuals of different backgrounds, cultures

Hayden, Nancy J.

6

Dixie Meadows Geothermal Area | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 NoPublic Utilities Address:011-DNA Jump to:52c8ff988c1Dering Harbor,DiscountDiversified EnergyDixie CountyHotMeadows

7

Lester Meadow, Washington- A Geothermal Anomaly | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow, Washington- A Geothermal

8

Greenland Meadows LID Case Study: Water Quality  

E-Print Network [OSTI]

Greenland Meadows LID Case Study: Water Quality Greenland Meadows is a retail shopping center built in 2008 by Newton, Mass.- based New England Development in Greenland, N.H. The development is located Development and Community Decisions can be found at http://www.unh.edu/unhsc/ftl/ Greenland Meadows features

10

Microsoft Word - LuckiamuteMeadows_CX.docx  

Broader source: Energy.gov (indexed) [DOE]

Welch Project Manager - KEWM-4 Proposed Action: Luckiamute Meadows property funding. Fish and Wildlife Project No.: 2011-003-00, Contract BPA-007071 Categorical Exclusion...

11

Meadow Ridge | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 No revision hasInformation Earth's Heat JumpIncMAKGalwayHydrothermalMcFarland is a cityMcleod 88II JumpLake

12

Greenland Meadows LID Case Study: Economics  

E-Print Network [OSTI]

Greenland Meadows LID Case Study: Economics Utilizing an LID approach that featured porous asphalt and a gravel wetland, a cost-competitive drainage system was designed for a large retail development. Greenland in Greenland, N.H. The development is located on a 56-acre parcel and includes three, one-story retail

13

Restore McComas Meadows; Meadow Creek Watershed, 2005-2006 Annual Report.  

SciTech Connect (OSTI)

The Nez Perce Tribe Department of Fisheries Resource Management, Watershed Division approaches watershed restoration with a ridge-top to ridge-top approach. Watershed restoration projects within the Meadow Creek watershed are coordinated and cost shared with the Nez Perce National Forest. The Nez Perce Tribe began watershed restoration projects within the Meadow Creek watershed of the South Fork Clearwater River in 1996. Progress has been made in restoring the watershed by excluding cattle from critical riparian areas through fencing, planting trees in riparian areas within the meadow and its tributaries, prioritizing culverts for replacement to accommodate fish passage, and decommissioning roads to reduce sediment input. During this contract period work was completed on two culvert replacement projects; Doe Creek and a tributary to Meadow Creek. Additionally construction was also completed for the ditch restoration project within McComas Meadows. Monitoring for project effectiveness and trends in watershed conditions was also completed. Road decommissioning monitoring, as well as stream temperature, sediment, and discharge were completed.

McRoberts, Heidi (Nez Perce Tribe, Department of Fisheries Resource Management, Lapwai, ID)

2006-07-01T23:59:59.000Z

14

Truckee Meadows Community College and Colorado School of Mines...  

Broader source: Energy.gov (indexed) [DOE]

student teams-from Truckee Meadows Community College in Reno, Nevada and Colorado School of Mines in Denver, Colorado-demonstrated exceptional rigor in their research and...

15

Endophytic Fungi in Meadow Fescue and Other Forage Grasses  

E-Print Network [OSTI]

Endophytic Fungi in Meadow Fescue and Other Forage Grasses Anja Bylin Faculty of Natural Resources uncinata (photo 3 and 4 from left) (photo: A. Bylin photo 1-3, S. Card photo 4 ) #12;Endophytic Fungi with an endophytic fungus of the genus Epichloë. In Sweden one of the most important forage grasses is meadow fescue

16

Environmental Impact Statement Truckee Meadows Flood Control Project  

E-Print Network [OSTI]

DRAFT Environmental Impact Statement for the Truckee Meadows Flood Control Project Nevada General Reevaluation Report Volume I ­ Draft Environmental Impact Statement prepared by U.S. Army Corps of Engineers Sacramento District May 2013 #12;#12;DRAFT Environmental Impact Statement for the Truckee Meadows Flood

US Army Corps of Engineers

17

Jump Starting GARCH: Pricing Options with Jumps in Returns and  

E-Print Network [OSTI]

Jump Starting GARCH: Pricing Options with Jumps in Returns and Volatilities J. Duan, P. Ritchken and volatilities. Our model nests Duan's GARCH option models where conditional returns are constrained to being normal, as well as extends Merton's jump-diffusion model by allowing return volatility to exhibit GARCH

Chaudhuri, Sanjay

18

Meadow Lake II | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 No revision hasInformation Earth's Heat JumpIncMAKGalwayHydrothermalMcFarland is a cityMcleod 88II Jump to:

19

Meadow Lake IV | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 No revision hasInformation Earth's Heat JumpIncMAKGalwayHydrothermalMcFarland is a cityMcleod 88II Jump

20

Meadow Lake Wind Farm | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 No revision hasInformation Earth's Heat JumpIncMAKGalwayHydrothermalMcFarland is a cityMcleod 88II JumpLake Wind

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Grand Meadow Wind Farm | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 No revision hasInformation Earth's Heat Jump to:Photon Place: Golden, COIndiana Jump to: navigation,Scale

22

Lester Meadow Geothermal Area | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola, Wisconsin:Leonidas,LeslieLessLester

23

Lester Meadow Geothermal Area | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,

24

Dixie Meadows Geothermal Area | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 No revision has beenFfe2fb55-352f-473b-a2dd-50ae8b27f0a6 No revision has TypeGeothermal Area Jump to: navigation,

25

Dixie Meadows Geothermal Project | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 No revision has beenFfe2fb55-352f-473b-a2dd-50ae8b27f0a6 No revision has TypeGeothermal Area Jump to:

26

Echo Meadows Project Winter Artificial Recharge.  

SciTech Connect (OSTI)

This report discusses the findings of the Echo Meadows Project (BPA Project 2001-015-00). The main purpose of this project is to artificially recharge an alluvial aquifer, WITH water from Umatilla River during the winter high flow period. In turn, this recharged aquifer will discharge an increased flow of cool groundwater back to the river, thereby improving Umatilla River water quality and temperature. A considerable side benefit is that the Umatilla River should improve as a habitat for migration, spanning, and rearing of anadromous and resident fish. The scope of this project is to provide critical baseline information about the Echo Meadows and the associated reach of the Umatilla River. Key elements of information that has been gathered include: (1) Annual and seasonal groundwater levels in the aquifer with an emphasis on the irrigation season, (2) Groundwater hydraulic properties, particularly hydraulic conductivity and specific yield, and (3) Groundwater and Umatilla River water quality including temperature, nutrients and other indicator parameters. One of the major purposes of this data gathering was to develop input to a groundwater model of the area. The purpose of the model is to estimate our ability to recharge this aquifer using water that is only available outside of the irrigation season (December through the end of February) and to estimate the timing of groundwater return flow back to the river. We have found through the data collection and modeling efforts that this reach of the river had historically returned as much as 45 cubic feet per second (cfs) of water to the Umatilla River during the summer and early fall. However, this return flow was reduced to as low as 10 cfs primarily due to reduced quantities of irrigation application, gain in irrigation efficiencies and increased groundwater pumping. Our modeling indicated that it is possible to restore these critical return flows using applied water outside of the irrigation season. We further found that this water can be timed to return to the river during the desired time of the year (summer to early fall). This is because the river stage, which remains relatively high until this time, drops during the irrigation season-thereby releasing the stored groundwater and increasing river flows. A significant side benefit is that these enhanced groundwater return flows will be clean and cold, particularly as compared to the Umatilla River. We also believe that this same type of application of water could be done and the resulting stream flows could be realized in other watersheds throughout the Pacific Northwest. This means that it is critical to compare the results from this baseline report to the full implementation of the project in the next phase. As previously stated, this report only discusses the results of data gathered during the baseline phase of this project. We have attempted to make the data that has been gathered accessible with the enclosed databases and spreadsheets. We provide computer links in this report to the databases so that interested parties can fully evaluate the data that has been gathered. However, we cannot emphasize too strongly that the real value of this project is to implement the phases to come, compare the results of these future phases to this baseline and develop the science and strategies to successfully implement this concept to other rivers in the Pacific Northwest. The results from our verified and calibrated groundwater model matches the observed groundwater data and trends collected during the baseline phase. The modeling results indicate that the return flows may increase to their historic values with the addition of 1 acre-ft/acre of recharge water to the groundwater system (about 9,600 acre-feet total). What this means is that through continued recharge project, you can double to quadruple the annual baseflow of the Umatilla River during the low summer and fall flow periods as compared to the present base-flow. The cool and high quality recharge water is a significant beneficial impact to the river system.

Ziari, Fred

2002-12-19T23:59:59.000Z

27

Mediterranean Seagrass Meadows: Resilience and Contribution to Climate Change Mitigation  

E-Print Network [OSTI]

Mediterranean Seagrass Meadows: Resilience and Contribution to Climate Change Mitigation A Short to Climate Change Mitigation, A Short Summary / Les herbiers de Magnoliophytes marines de Méditerranée: 1 Evolution of the average temperature and level of the sea since 1850 (after Climate Change 2007

Boudouresque, Charles F.

28

Hydraulic jumps on an incline  

E-Print Network [OSTI]

When a fluid jet strikes an inclined solid surface at normal incidence, gravity creates a flow pattern with a thick outer rim resembling a parabola and reminiscent of a hydraulic jump. There appears to be little theory or experiments describing simple aspects of this phenomenon, such as the maximum rise height of the fluid above the impact point, and its dependence on jet velocity and inclination angle. We address this with experiments, and present a simple theory based on horizontal hydraulic jumps which accounts for the rise height and its scaling, though without describing the shape of the parabolic envelope.

Jean-Luc Thiffeault; Andrew Belmonte

2010-09-01T23:59:59.000Z

29

Viscous Hydraulic Jumps Submitted by  

E-Print Network [OSTI]

Viscous Hydraulic Jumps Submitted by Jeffrey M. Aristoff, Jeffrey D. Leblanc, Annette E. Hosoi, and John W. M. Bush, Massachusetts Institute of Technology We examine the form of the viscous hydraulic of height 2­10 mm. Elegaard et al.1 first demonstrated that the axial symme- try of the viscous hydraulic

Bush, John W.M.

30

Princeton Meadows, New Jersey: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy ResourcesLoadingPenobscot County, Maine:Plug Power IncPowderClimateMeadows, New Jersey: Energy Resources

31

Numerical Study of a Turbulent Hydraulic Jump  

E-Print Network [OSTI]

Numerical Study of a Turbulent Hydraulic Jump Qun Zhao, Shubhra Misra, Ib. A. Svendsen and James T of a Turbulent Hydraulic Jump ­ p.1/14 #12;Objective Our ultimate goal is to study the breaking waves. Numerical Study of a Turbulent Hydraulic Jump ­ p.2/14 #12;A moving bore Qiantang Bore China (Courtesy of Dr J

Zhao, Qun

32

JLab Meadows Offer Environmental Benefits and Beauty | Jefferson Lab  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfrared LandResponsesIon/SurfacePump-TestingJEDI: Jobs andJGICompletesMeadows

33

Rolling Meadows, Illinois: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating Solar PowerstoriesNrelPartnerType JumpJersey) Jump to:

34

New Meadows, Idaho: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy ResourcesLoading map...(Utility Company) Jump to: navigation, searchOhio:MO) Jump to:

35

Hidden Meadows, California: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to: navigation,Ohio:GreerHi Gtel Jump to: navigation, search Name:HickamHills is

36

Homestead Meadows North, Texas: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to: navigation,Ohio:GreerHi GtelHomer, Alaska: Energy Resources Jump to:North, Texas:

37

Homestead Meadows South, Texas: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to: navigation,Ohio:GreerHi GtelHomer, Alaska: Energy Resources Jump to:North,

38

White Meadow Lake, New Jersey: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia:FAQ < RAPID Jump to:SeadovCooperative Jump to:Westview,

39

Abies lasiocarpa establishment of subalpine meadows in Glacier National Park, Montana  

E-Print Network [OSTI]

, and forest establishment. Both forest and meadow categories showed significant inverse trends in Pacific Decadal Oscillation and establishment. These data indicate warmer fall temperatures and alteration in snowpack lengthen the growing season and provide...

40

Bubble visualization in a simulated hydraulic jump  

E-Print Network [OSTI]

This is a fluid dynamics video of two- and three-dimensional computational fluid dynamics simulations carried out at St. Anthony Falls Laboratory. A transient hydraulic jump is simulated using OpenFOAM, an open source numerical solver. A Volume of Fluid numerical method is employed with a realizable k-epsilon turbulence model. The goal of this research is to model the void fraction and bubble size in a transient hydraulic jump. This fluid dynamics video depicts the air entrainment characteristics and bubble behavior within a hydraulic jump of Froude number 4.82.

Witt, Adam; Shen, Lian

2013-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Meadow Town Corporation (Utility Company) | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating Solar Powerstories on climateJunoMedanosElectric Co Ltd JumpMcKenzie

42

The hydraulic jump as a white hole  

E-Print Network [OSTI]

In the geometry of the circular hydraulic jump, the velocity of the liquid in the interior region exceeds the speed of capillary-gravity waves (ripplons), whose spectrum is `relativistic' in the shallow water limit. The velocity flow is radial and outward, and thus the relativistic ripplons cannot propagating into the interior region. In terms of the effective 2+1 dimensional Painleve-Gullstrand metric appropriate for the propagating ripplons, the interior region imitates the white hole. The hydraulic jump represents the physical singularity at the white-hole horizon. The instability of the vacuum in the ergoregion inside the circular hydraulic jump and its observation in recent experiments on superfluid 4He by E. Rolley, C. Guthmann, M.S. Pettersen and C. Chevallier in physics/0508200 are discussed.

G. E. Volovik

2005-10-21T23:59:59.000Z

43

A Model For Polygonal Hydraulic Jumps  

E-Print Network [OSTI]

We propose a phenomenological model for the polygonal hydraulic jumps discovered by Ellegaard et al., based on the known flow structure for the type II hydraulic jumps with a "roller" (separation eddy) near the free surface in the jump region. The model consists of mass conservation and radial force balance between hydrostatic pressure and viscous stresses on the roller surface. In addition, we consider the azimuthal force balance, primarily between pressure and viscosity, but also including non-hydrostatic pressure contributions from surface tension in light of recent observations by Bush et al. The model can be analyzed by linearization around the circular state, resulting in a parameter relationship for nearly circular polygonal states. A truncated, but fully nonlinear version of the model can be solved analytically. This simpler model gives rise to polygonal shapes that are very similar to those observed in experiments, even though surface tension is neglected, and the condition for the existence of a pol...

Martens, Erik A; Bohr, Tomas

2011-01-01T23:59:59.000Z

44

Jump to first page Promoting Health,  

E-Print Network [OSTI]

Breastfeeding Poor Nutrition - Food Preferences Low physical activity Lack of sleep #12;Jump to first page protein during pregnancy, has strong implications for future metabolic health. Undernourished infant children 3 years later. Data from mother's diet history and umbilical cord blood The increase

45

Jump to first page American Planning Association  

E-Print Network [OSTI]

to first page How Smart is your Community? Small group exercise 5. CENTRAL CITY VITALITY Examples: GradeJump to first page American Planning Association Core Smart Growth Principles 1) INCREASED CITIZEN, adaptive re-use) 5) CENTRAL CITY VITALITY 6) GREATER MIX OF USES AND HOUSING CHOICES FOCUSED AROUND HUMAN

46

Meadow Lake II (3Q10) | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 No revision hasInformation Earth's Heat JumpIncMAKGalwayHydrothermalMcFarland is a cityMcleod 88

47

Meadow Acres, Wyoming: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey,(MonasterLowellisMcDonald is a boroughMcPherson County isMeade

48

Meadow Woods, Florida: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey,(MonasterLowellisMcDonald is a boroughMcPherson County isMeadeWoods,

49

Meadows Place, Texas: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey,(MonasterLowellisMcDonald is a boroughMcPherson County6513439°,

50

Intestinal absorption and secretion of total and lipid phosphorus in adult sheep fed chopped meadow hay  

E-Print Network [OSTI]

Intestinal absorption and secretion of total and lipid phosphorus in adult sheep fed chopped meadow total and lipid P secretion observed between the mouth and the duodenal cannula could be accounted experiment using 144Ce as an unabsorbable marker, we observed considerable total and lipid P secretion

Paris-Sud XI, Université de

51

Hydraulic/Shock-Jumps in Protoplanetary Disks  

E-Print Network [OSTI]

In this paper, we describe the nonlinear outcome of spiral shocks in protoplanetary disks. Spiral shocks, for most protoplanetary disk conditions, create a loss of vertical force balance in the post-shock region and result in rapid expansion of the gas perpendicular to the disk midplane. This expansion has characteristics similar to hydraulic jumps, which occur in incompressible fluids. We present a theory to describe the behavior of these hybrids between shocks and hydraulic jumps (shock bores) and then compare the theory to three-dimensional hydrodynamics simulations. We discuss the fully three-dimensional shock structures that shock bores produce and discuss possible consequences for disk mixing, turbulence, and evolution of solids.

A. C. Boley; R. H. Durisen

2006-03-10T23:59:59.000Z

52

Bell's Jump Process in Discrete Time  

E-Print Network [OSTI]

The jump process introduced by J. S. Bell in 1986, for defining a quantum field theory without observers, presupposes that space is discrete whereas time is continuous. In this letter, our interest is to find an analogous process in discrete time. We argue that a genuine analog does not exist, but provide examples of processes in discrete time that could be used as a replacement.

Jonathan Barrett; Matthew Leifer; Roderich Tumulka

2005-09-27T23:59:59.000Z

53

Electrowetting study of jumping droplets on hydrophobic surfaces  

E-Print Network [OSTI]

Recent studies have shown that jumping-droplet-enhanced condensation has higher heat transfer than state-of-the-art dropwise condensing surfaces by -30-40%. Jumping-droplet condensation occurs due to the conversion of ...

Tio, Evelyn

2014-01-01T23:59:59.000Z

54

Productivity, detritus formation and grazing of the seagrass Thalassia testudinum Banks in Caribbean meadows: a simulative numerical model  

E-Print Network [OSTI]

and meadows formed by the sea- grasses Zostera marina L. (eelgrass), Posidonia australis Hooker and the turtlegrass T. testudinum. A~1 al mats A ;ge -e sliced mathematical odel for coastal e o- systems containing seaweeds was developed by Belyaev et al... community in relation to temperature and biotic interactions. A comparison between the predicted and observed temporal patterns of the seagrass biomass was presented. Posi donia meadows . ? Ki rkman 5 Reid ( 1979) studied the role of P. australis...

Victoria-Rueda, Carlos Humberto

1981-01-01T23:59:59.000Z

55

CAPTURE OF TROJANS BY JUMPING JUPITER  

SciTech Connect (OSTI)

Jupiter Trojans are thought to be survivors of a much larger population of planetesimals that existed in the planetary region when planets formed. They can provide important constraints on the mass and properties of the planetesimal disk, and its dispersal during planet migration. Here, we tested a possibility that the Trojans were captured during the early dynamical instability among the outer planets (aka the Nice model), when the semimajor axis of Jupiter was changing as a result of scattering encounters with an ice giant. The capture occurs in this model when Jupiter's orbit and its Lagrange points become radially displaced in a scattering event and fall into a region populated by planetesimals (that previously evolved from their natal transplanetary disk to {approx}5 AU during the instability). Our numerical simulations of the new capture model, hereafter jump capture, satisfactorily reproduce the orbital distribution of the Trojans and their total mass. The jump capture is potentially capable of explaining the observed asymmetry in the number of leading and trailing Trojans. We find that the capture probability is (6-8) Multiplication-Sign 10{sup -7} for each particle in the original transplanetary disk, implying that the disk contained (3-4) Multiplication-Sign 10{sup 7} planetesimals with absolute magnitude H < 9 (corresponding to diameter D = 80 km for a 7% albedo). The disk mass inferred from this work, M{sub disk} {approx} 14-28 M{sub Earth}, is consistent with the mass deduced from recent dynamical simulations of the planetary instability.

Nesvorny, David [Department of Space Studies, Southwest Research Institute, 1050 Walnut St., Suite 300, Boulder, CO 80302 (United States); Vokrouhlicky, David [Institute of Astronomy, Charles University, V Holesovickach 2, 180 00 Prague 8 (Czech Republic); Morbidelli, Alessandro [Departement Cassiopee, University of Nice, CNRS, Observatoire de la Cote d'Azur, Nice, F-06304 (France)

2013-05-01T23:59:59.000Z

56

Viscous Undular Hydraulic Jumps of Moderate Reynolds number  

E-Print Network [OSTI]

Viscous Undular Hydraulic Jumps of Moderate Reynolds number Ratul Dasgupta I will present some results on undular hydraulic jumps occurring in a two bores (in rivers), where the interface remains horizontal, the moderate Reynolds hydraulic jump shows a linear increase in height due to viscosity

Shyamasundar, R.K.

57

Survivorship of meadow voles, Microtus pennsylvanicus, from sewage sludge-treated fields  

SciTech Connect (OSTI)

A long-term field study was begun in 1977 at Miami University to evaluate the effects of land application of sewage sludge on experimental old-field communities. The effects of sludge application on toxic metal concentrations in meadow vole (Microtus pennsylvanicus) organs during the first two years of the study have been reported. During the first two years of sludge application, no detrimental effects were observed in vole survivorship as a result of sludge treatment.

Maly, M.S.

1984-06-01T23:59:59.000Z

58

Lift-off dynamics in a simple jumping robot  

E-Print Network [OSTI]

We study vertical jumping in a simple robot comprising an actuated mass-spring arrangement. The actuator frequency and phase are systematically varied to find optimal performance. Optimal jumps occur above and below (but not at) the robot's resonant frequency $f_0$. Two distinct jumping modes emerge: a simple jump which is optimal above $f_0$ is achievable with a squat maneuver, and a peculiar stutter jump which is optimal below $f_0$ is generated with a counter-movement. A simple dynamical model reveals how optimal lift-off results from non-resonant transient dynamics.

Jeffrey Aguilar; Alex Lesov; Kurt Wiesenfeld; Daniel I. Goldman

2012-08-30T23:59:59.000Z

59

Swing Options Valuation: a BSDE with Constrained Jumps Approach  

E-Print Network [OSTI]

Swing Options Valuation: a BSDE with Constrained Jumps Approach Marie Bernhart Huy^en Pham Peter Tankov Xavier Warin§ January 7, 2011 Abstract We introduce a new probabilistic method for solving a class (BSDEs for short) with constrained jumps. As an example, our method is used for pricing Swing options. We

60

Hamilton-Jacobi equations with jumps: asymptotic stability  

E-Print Network [OSTI]

The asymptotic stability of a global solution satisfying Hamilton-Jacobi equations with jumps will be analyzed in dependence on the strong dissipativity of the jump control function and using orbits of the differentiable flows to describe the corresponding characteristic system.

Amir Mahmood; Saima Parveen

2009-09-05T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

ISSN 1745-9648 Gasoline Prices Jump Up on Mondays  

E-Print Network [OSTI]

ISSN 1745-9648 Gasoline Prices Jump Up on Mondays: an Outcome of Aggressive Competition? by Ã?ystein Research Council is gratefully acknowledged. #12;Gasoline prices jump up on Mondays: An outcome, 2008 Abstract This paper examines Norwegian gasoline pump prices using daily station

Feigon, Brooke

62

266 CHIL. J. AGRIC. RES. -VOL. 70 -N 2 -2010 VARIABILITY OF SOIL TYPES IN WETLAND MEADOWS IN THE SOUTH  

E-Print Network [OSTI]

IN THE SOUTH OF THE CHILEAN PATAGONIA Ladislava Filipová1* , Radim Hédl2 , and Nilo Covacevich C.3 ABSTRACT Patagonia are productive and intensively exploited ecosystems. However, there is scarce data about and canyons of Patagonia, produced by the fusion of Pleistocene glaciers, there are wetland meadows locally

Hédl, Radim

63

Jumping-Droplet-Enhanced Condensation on Scalable Superhydrophobic Nanostructured Surfaces  

E-Print Network [OSTI]

When droplets coalesce on a superhydrophobic nanostructured surface, the resulting droplet can jump from the surface due to the release of excess surface energy. If designed properly, these superhydrophobic nanostructured ...

Miljkovic, Nenad

64

CONFINEMENT BY BIASED VELOCITY JUMPS: AGGREGATION OF ESCHERICHIA COLI  

E-Print Network [OSTI]

by a jump process or by Brownian motion combined with accel- eration by the force field produced]. In this work a related type of particle dynamics is considered, where confinement is achieved by a biased

Schmeiser, Christian

65

Circular hydraulic jump in generalized-Newtonian fluids  

E-Print Network [OSTI]

We carry out an analytical study of laminar circular hydraulic jumps, in generalized-Newtonian fluids obeying the two-parametric power-law model of Ostwald-de Waele. Under the boundary-layer approximation we obtained exact expressions determining the flow, an implicit relation for the jump radius is derived. Corresponding results for Newtonian fluids can be retrieved as a limiting case for the flow behavior index n=1, predictions are made for fluids deviating from Newtonian behavior.

Rai, Ashutosh; Poria, Swarup

2008-01-01T23:59:59.000Z

66

Gravity-free hydraulic jumps and metal femtocups  

E-Print Network [OSTI]

Hydraulic jumps created by gravity are seen every day in the kitchen sink. We show that at small scales a circular hydraulic jump can be created in the absence of gravity, by surface tension. The theory is motivated by our experimental finding of a height discontinuity in spreading submicron molten metal droplets created by pulsed-laser ablation. By careful control of initial conditions, we show that this leads to solid femtolitre cups of gold, silver, copper, niobium and tin.

Rama Govindarajan; Manikandan Mathur; Ratul DasGupta; N. R. Selvi; Neena Susan John; G. U. Kulkarni

2006-10-03T23:59:59.000Z

67

Chemical Potential Jump during Evaporation of a Quantum Bose Gas  

E-Print Network [OSTI]

The dependence of the chemical potential jump coefficient on the evaporation coefficient is analyzed for the case in which the evaporating component is a Bose gas. The concentration of the evaporating component is assumed to be much lower than the concentration of the carrier gas. The expression for the chemical potential jump is derived from the analytic solution of the problem for the case in which the collision frequency of molecules of the evaporating component is constant.

E. A. Bedrikova; A. V. Latyshev

2013-01-07T23:59:59.000Z

68

Multispectral Imaging At Dixie Meadows Area (Pickles, Et Al., 2003) | Open  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 -Energieprojekte3 ClimateSpurr GeothermalCarmelAlum Area (DOE GTP) Jump

69

Soil Sampling At Lester Meadow Area (Vice, 2008) | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia:FAQ < RAPID Jump to:Seadov Pty Ltd Jump to: navigation,PvtSouthInformationIInformation

70

Air Quality Scoping Study for Ash Meadows National Wildlife Refuge, Nevada (EMSI April 2007)  

SciTech Connect (OSTI)

The Desert Research Institute (DRI) is performing a scoping study as part of the U.S.Department of Energy’s Yucca Mountain Environmental Monitoring Systems Initiative (EMSI). The main objective is to obtain baseline air quality information for Yucca Mountain and an area surrounding the Nevada Test Site (NTS). Air quality and meteorological monitoring and sampling equipment housed in a mobile trailer (shelter) is collecting data at seven sites outside the NTS, including Ash Meadows National Wildlife Refuge, Sarcobatus Flat, Beatty, Rachel, Caliente, Pahranagat National Wildlife Refuge, and Crater Flat, and at four sites on the NTS. The trailer is stationed at any one site for approximately eight weeks at a time. Letter reports provide summaries of air quality and meteorological data, on completion of each site’s sampling program.

Johann Engelbrecht, Ilias Kavouras, Dave Campbell, Scott Campbell, Steven Kohl and David Shafer

2007-04-01T23:59:59.000Z

71

Case Study: Mobile Photovoltaic System at Bechler Meadows Ranger Station, Yellowstone National Park (Brochure)  

SciTech Connect (OSTI)

The mobile PV/generator hybrid system deployed at Bechler Meadows provides a number of advantages. It reduces on-site air emissions from the generator. Batteries allow the generator to operate only at its rated power, reducing run-time and fuel consumption. Energy provided by the solar array reduces fuel consumption and run-time of the generator. The generator is off for most hours providing peace and quiet at the site. Maintenance trips from Mammoth Hot Springs to the remote site are reduced. The frequency of intrusive fuel deliveries to the pristine site is reduced. And the system gives rangers a chance to interpret Green Park values to the visiting public. As an added bonus, the system provides all these benefits at a lower cost than the basecase of using only a propane-fueled generator, reducing life cycle cost by about 26%.

Not Available

2014-03-01T23:59:59.000Z

72

Lower Red River Meadow Restoration Project : Biennial Report 1996-97.  

SciTech Connect (OSTI)

The Red River has been straightened and the riparian vegetation corridor eliminated in several reaches within the watershed. The river responded by incision resulting in over-steepened banks, increased sedimentation, elevated water temperatures, depressed groundwater levels, reduced floodplain function, and degraded fish habitat. The Lower Red River Meadow Restoration Project is a multi-phase ecosystem enhancement effort that restores natural physical and biological processes and functions to stabilize the stream channel and establish high quality habitats for fish and wildlife. A natural channel restoration philosophy guides the design and on the ground activities, allowing the channel to evolve into a state of dynamic equilibrium. Two years of planning, two years of restoration in Phases I and II, and one year post-restoration monitoring are complete. By excavating new bends and reconnecting historic meanders, Phase I and II channel realignment increased channel length by 3,060 feet, decreased channel gradient by 25 percent, and increased sinuosity from 1.7 to 2.3. Cross-sectional shapes and point bars were modified to maintain deep pool habitat at low flow and to reconnect the meadow floodplain. Improved soil moisture conditions will help sustain the 31,500 native riparian plantings reestablished within these two phases. Overall, short-term restoration performance was successful. Analyses of long-term parameters document either post-restoration baseline conditions or early stages of evolution toward desired conditions. An adaptive management strategy has helped to improve restoration designs, methods, and monitoring. Lessons learned are being transferred to a variety of audiences to advance the knowledge of ecological restoration and wise management of watersheds.

LRK Communications; Wildlife Habitat Institute; Pocket Water, Inc.

2003-07-01T23:59:59.000Z

73

Anthropic prediction for a large multi-jump landscape  

E-Print Network [OSTI]

The assumption of a flat prior distribution plays a critical role in the anthropic prediction of the cosmological constant. In a previous paper we analytically calculated the distribution for the cosmological constant, including the prior and anthropic selection effects, in a large toy ``single-jump'' landscape model. We showed that it is possible for the fractal prior distribution we found to behave as an effectively flat distribution in a wide class of landscapes, but only if the single jump size is large enough. We extend this work here by investigating a large ($N \\sim 10^{500}$) toy ``multi-jump'' landscape model. The jump sizes range over three orders of magnitude and an overall free parameter $c$ determines the absolute size of the jumps. We will show that for ``large'' $c$ the distribution of probabilities of vacua in the anthropic range is effectively flat, and thus the successful anthropic prediction is validated. However, we argue that for small $c$, the distribution may not be smooth.

Delia Schwartz-Perlov

2008-09-04T23:59:59.000Z

74

Genomic analysis of mouse tumorigenesis  

E-Print Network [OSTI]

The availability of the human and mouse genome sequences has spurred a growing interest in analyzing mouse models of human cancer using genomic techniques. Comparative genomic studies on mouse and human tumors can be ...

Tam, Mandy Chi-Mun

2006-01-01T23:59:59.000Z

75

Climate, geography, and tree establishment in Subalpine Meadows of the Olympic Mountains, Washington, U.S.A.  

SciTech Connect (OSTI)

Noticeable changes in vegetation distribution have occurred in the Pacific Northwest during the last century as trees have established in some subalpine meadows. To study the relationship of this process to climate, recently established trees were aged in six subalpine meadows in the Olympic Mountains, Washington. The sites represent three points along a steep precipitation gradient. Subalpine fir (Abies lasiocarpa) has been establishing at the dry end of the gradient, mountain hemlock (Tsuga mertensiana) at the wet end, and both species in the center. Establishment patterns were compared with deviations from the century-long average for these weather variables: winter precipitation, Palmer Drought Severity Index, and winter, October and May temperatures. Results show that establishment occurred in dry areas when weather conditions were wetter than average, and in wet areas under drier than average conditions. Establishment at central sites did not show consistent relationships with climate. If future climatic conditions continue to warm, establishment of subalpine fir in subalpine meadows in dry areas may cease and mountain hemlock may resume in wet areas. 34 refs., 5 figs., 3 tabs.

Woodward, A.; Silsbee, D.G. [Univ. of Washington, Seattle, WA (United States); Schreiner, E.G. [National Biological Service, Port Angeles, WA (United States)

1995-08-01T23:59:59.000Z

76

HEART RATE VARIABILITY AS DETERMINISM WITH JUMP STOCHASTIC PARAMETERS  

E-Print Network [OSTI]

HEART RATE VARIABILITY AS DETERMINISM WITH JUMP STOCHASTIC PARAMETERS JIONGXUAN ZHENG, JOE SKUFCA, AND ERIK BOLLT§ Abstract. We use measured heart rate information (RR intervals) to develop a one with persistence which causes the heart rate and rhythm system to wander about a bifurcation point. We propose

Bollt, Erik

77

Delayed Frost Growth on Jumping-Drop Superhydrophobic Surfaces  

SciTech Connect (OSTI)

Self-propelled jumping drops are continuously removed from a condensing superhydrophobic surface to enable a micrometric steady-state drop size. Here, we report that subcooled condensate on a chilled superhydrophobic surface are able to repeatedly jump off the surface before heterogeneous ice nucleation occurs. Frost still forms on the superhydrophobic surface due to ice nucleation at neighboring edge defects, which eventually spreads over the entire surface via an inter-drop frost wave. The growth of this inter-drop frost front is shown to be up to three times slower on the superhydrophobic surface compared to a control hydrophobic surface, due to the jumping-drop effect dynamically minimizing the average drop size and surface coverage of the condensate. A simple scaling model is developed to relate the success and speed of inter-drop ice bridging to the drop size distribution. While other reports of condensation frosting on superhydrophobic surfaces have focused exclusively on liquid-solid ice nucleation for isolated drops, these findings reveal that the growth of frost is an inter-drop phenomenon that is strongly coupled to the wettability and drop size distribution of the surface. A jumping-drop superhydrophobic condenser was found to be superior to a conventional dropwise condenser in two respects: preventing heterogeneous ice nucleation by continuously removing subcooled condensate, and delaying frost growth by minimizing the success of interdrop ice bridge formation.

Boreyko, Jonathan B [ORNL; Collier, Pat [ORNL

2013-01-01T23:59:59.000Z

78

Stabilising entanglement by quantum jump-based feedback  

E-Print Network [OSTI]

We show that direct feedback based on quantum jump detection can be used to generate entangled steady states. We present a strategy that is insensitive to detection inefficiencies and robust against errors in the control Hamiltonian. This feedback procedure is also shown to overcome spontaneous emission effects by stabilising states with high degree of entanglement.

A. R. R. Carvalho; J. J. Hope

2007-05-24T23:59:59.000Z

79

Jump-Di usion Stock Return Models in Finance: Stochastic Process Density with Uniform-Jump Amplitude  

E-Print Network [OSTI]

-time, geometric, jump-di usion stochastic di erential equation (SDE), dS(t) = S(t) ddt + ddZ(t) + J(Q)dP (t)] S(0 and are constants. The di erential di usion process with drift ddt + ddZ(t) is has mean ddt and ddt variance

Hanson, Floyd B.

80

Orthogonal jumps of wavefunction in white-noise potentials  

E-Print Network [OSTI]

We investigate the evolution of the quantum state for a free particle placed into a random external potential of white-noise type. The master equation for the density matrix is derived by means of path integral method. We propose an equivalent stochastic process where the wavefunction satisfies a nonlinear Schr\\"odinger equation except for random moments at which it shows orthogonal jumps. The relation of our work to the usual theory of quantum noise and damping is briefly discussed.

Lajos Diósi

2015-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Measuring the Balmer Jump and Effective Gravity in FGK Stars  

E-Print Network [OSTI]

It is difficult to accurately measure the effective gravity (log g) in late-type stars using broadband (eg. UBV or SDSS) or intermediate-band (uvby) photometric systems, especially when the stars can cover a range of metallicities and reddenings. However, simple spectroscopic observational and data reduction techniques can yield accurate values for log g through comparison of the Balmer jumps of low-resolution spectra with recent grids of synthetic flux spectra.

Bessell, Michael S

2007-01-01T23:59:59.000Z

82

Ultraviolet and Green Receptors in Principal Eyes of Jumping Spiders  

E-Print Network [OSTI]

ABSTRACT Spectral sensitivities of cells in principal eyes of the jumping spider Phidippus reqius were measured using techniques of intraceUular recording. Three types of cells were found. UV ceils had peak sensitivities at 370 nm and were over 4 log units less sensitive at wavelengths longer than 460 nm. Green-sensitive cells had spectral sensitivities which were well fit by nomogram curves peaking at 532 nm. UV-green ceils had dual peaks of sensitivity at about 370 and 525 nm, but the ratios of UV-to-green sensitivities varied over a 40:1 range from cell to cell. Moreover, responses of UV-green cells to flashes of UV light were slower than to flashes of green light. Segregation of receptor types into the known layers of receptors in these eyes could not be shown. It is concluded that jumping spiders have the potential for dichromatic color vision. The brightly colored, keen-sighted jumping spiders have long been considered the possessers of color vision. Peckham and Peckham (1894) claimed that males of a number of species ( Dendryphantes elegans, Saitis pulex, Phiddipus rufus, and Astia vittata) used color clues to identify females (of the same species)

Robert D. D~. Voe

83

Reds Meadow Hot Springs Pool & Spa Low Temperature Geothermal Facility |  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia:FAQ < RAPID Jump to: navigation, search RAPIDColoradosourceRausWyoming: EnergyElec AssnRedmond,Open Energy

84

Jump Steady Resort Space Heating Low Temperature Geothermal Facility | Open  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429 Throttled (botOpen6 Climate ZoneJeromeCounty is aJosephJumao Photonics Co

85

Multispectral Imaging At Dixie Meadows Area (Martin, Et Al., 2004) | Open  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home5b9fcbce19 No revision hasInformation Earth's HeatMexico: EnergyMithun Jump to:MoeInformation MulkCalvin, 2009)Energy

86

Twelve Months of Air Quality Monitoring at Ash Meadows National Wildlife Refuge, Southwestern Rural Nevada, U.S.A (EMSI April 2007)  

SciTech Connect (OSTI)

The one year of air quality monitoring data collected at the Ash Meadows National Wildlife Refuge (NWR) was the final part of the air quality "Scoping Studies" for the Environmental Monitoring Systems Initiative (EMSI) in southern and central Nevada. The objective of monitoring at Ash Meadows was to examine aerosol and meteorological data, seasonal trends in aerosol and meteorological parameters as well as to examine evidence for long distance transport of some constituents. The 9,307 hectare refuge supports more than 50 springs and 24 endemic species, including the only population of the federally listed endangered Devil’s Hole pupfish (Cyprinodon diabolis) (U.S. Fish and Wildlife Service, 1990). Ash Meadows NWR is located in a Class II air quality area, and the aerosol measurements collected with this study are compared to those of Interagency Monitoring of Protected Visual Environments (IMPROVE) sites. Measurements taken at Ash Meadows NWR over a period of 12 months provide new baseline air quality and meteorological information for rural southwestern Nevada, specifically Nye County and the Amargosa Valley.

Engelbrecht, Johann P; Shafer, David S; Campbell, Dave; Campbell, Scott; McCurdy, Greg; Kohl, Steven D; Nikolich, George; Sheetz, Larry

2011-08-01T23:59:59.000Z

87

Markov Jump Processes Approximating a Non-Symmetric Generalized Diffusion  

SciTech Connect (OSTI)

Consider a non-symmetric generalized diffusion X( Dot-Operator ) in Double-Struck-Capital-R {sup d} determined by the differential operator A(x) = -{Sigma}{sub ij} {partial_derivative}{sub i}a{sub ij}(x){partial_derivative}{sub j} + {Sigma}{sub i} b{sub i}(x){partial_derivative}{sub i}. In this paper the diffusion process is approximated by Markov jump processes X{sub n}( Dot-Operator ), in homogeneous and isotropic grids G{sub n} Subset-Of Double-Struck-Capital-R {sup d}, which converge in distribution in the Skorokhod space D([0,{infinity}), Double-Struck-Capital-R {sup d}) to the diffusion X( Dot-Operator ). The generators of X{sub n}( Dot-Operator ) are constructed explicitly. Due to the homogeneity and isotropy of grids, the proposed method for d{>=}3 can be applied to processes for which the diffusion tensor {l_brace}a{sub ij}(x){r_brace}{sub 11}{sup dd} fulfills an additional condition. The proposed construction offers a simple method for simulation of sample paths of non-symmetric generalized diffusion. Simulations are carried out in terms of jump processes X{sub n}( Dot-Operator ). For piece-wise constant functions a{sub ij} on Double-Struck-Capital-R {sup d} and piece-wise continuous functions a{sub ij} on Double-Struck-Capital-R {sup 2} the construction and principal algorithm are described enabling an easy implementation into a computer code.

Limic, Nedzad, E-mail: nlimic@math.hr [University of Zagreb, Dept. of Mathematics (Croatia)

2011-08-15T23:59:59.000Z

88

Internal geophysics (Physics of Earth's interior) Jump conditions and dynamic surface tension at permeable  

E-Print Network [OSTI]

Internal geophysics (Physics of Earth's interior) Jump conditions and dynamic surface tension of momentum across the interface, a possibly anisotropic surface tension and terms including an inter- face equals the jump of pressure; and in the presence of surface tension defined as a capillary action due

89

Inverting the Turing Jump in Complexity Theory Stephen A. Fenner \\Lambda  

E-Print Network [OSTI]

Inverting the Turing Jump in Complexity Theory Stephen A. Fenner \\Lambda Computer Science Department University of Southern Maine Abstract This paper investigates the invertibility of certain analogs­jump operators are not invertible, i.e., there is a PSPACE­hard (resp. EXP­hard) set that is not p­ time Turing

Fenner, Stephen

90

Impact of jumps on returns and realised variances: econometric analysis of time-deformed Levy processes  

E-Print Network [OSTI]

Impact of jumps on returns and realised variances: econometric analysis of time-deformed L In order to assess the effect of jumps on realised variance calculations, we study some of the econometric econometric work on realised variance. Keywords: Kalman filter, L´evy process, Long-memory, Quasi

Wolfe, Patrick J.

91

Vacancy Jumps in PdIn: Reconciling Nuclear Relaxation and Diffusion Measurements  

E-Print Network [OSTI]

Vacancy Jumps in PdIn: Reconciling Nuclear Relaxation and Diffusion Measurements Gary S. Collins Keywords: point defect, vacancy, diffusion, defect interaction, intermetallic compound, perturbed angular correlation, PAC, nuclear relaxation, diffusion mechanisms Abstract. Vacancy jump frequencies in PdIn were

Collins, Gary S.

92

E-Print Network 3.0 - alkaline ph jump Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for Disease Control and Prevention National Center for Environmental Health Summary: total alkalinity, the pH is unstable, and therefore you would have dramatic jumps in pH from...

93

Discrete time approximation of decoupled Forward-Backward SDE with jumps  

E-Print Network [OSTI]

+ T n h X ti , ¯Y ti , ¯Z ti where ¯Y tn := g(X tn ) and Wi+1 := Wti+1 - Wti . In the no-jump case

Elie, Romuald

94

BPA-Solicited Technical Review of "Echo Meadows Project Winter Artificial Recharge: Final Report for 2001 Baseline", Technical Report 2004.  

SciTech Connect (OSTI)

The purpose of this report was to provide, at BPA's request, a technical review of interim products received for Project 2001-015-00 under contract 6925. BPA sometimes solicits technical reviews for Fish and Wildlife products or issues where outside expertise is required. External review of complex project deliverables assures BPA as a funding agency that the contractor is continuing with scientifically-credible experimental techniques envisioned in the original proposal. If the project's methodology proves feasible, there could be potential applications beyond the project area to similar situations in the Columbia Basin. The Experiment involves artificial flooding during high flow periods and a determination of the portion of the return flows that end up in the Umatilla River during low flow months and within acceptable water quality parameters (e.g., low temperature, few contaminants). Flooding could be a critical water source for aquatic organisms at times of the year when flows in the lower reaches of the Umatilla River are low and water is warmer than would be desired. The experiment was proposed to test whether 'this process, recharges the shallow aquifers of the old flood plain, for natural filtration through the alluvial soils as it returns to the Umatilla River, cleaner and cooler (about 50 degree Fahrenheit) five to six month later (about July and August) substantially cooling the river and [making it] more beneficial to anadromous [fish]'. A substantial amount of preliminary data had been collected and preliminary results were submitted in an interim report 'Echo Meadows Project Winter Artificial Recharge: Final Report for 2001 Baseline (December 2002)'. A substantial amount of addition funding was provided for the last cycle of flooding (Phases II) and final analyses of the full compliment of data collected over the life of the contract (Phase III). Third party scientific review may assist the contractor in producing a higher quality Final Report with completion of the final 2 phases of the project.

Morgan, David

2004-02-01T23:59:59.000Z

95

Bow-wave-like hydraulic jump and horseshoe vortex around an obstacle in a supercritical open channel flow  

E-Print Network [OSTI]

Bow-wave-like hydraulic jump and horseshoe vortex around an obstacle in a supercritical open the obstacle, two main flow structures are observed: i a hydraulic jump in the near-surface region and ii turbulent regime , the detachment length of the hydraulic jump exceeds the one of the horseshoe vortex

Boyer, Edmond

96

Effect of shockwave-induced density jump on laser plasma interactions in low-pressure ambient air  

E-Print Network [OSTI]

1 Effect of shockwave-induced density jump on laser plasma interactions in low-pressure ambient air jump were investigated in low- pressure ambient air during the laser pulse using an optical interferometer. A tiny shockwave-induced density jump could be observed clearly in ambient air with pressure

Tillack, Mark

97

Sinkpad: A Malleable Mouse Pad Consisted of an Elastic Material  

E-Print Network [OSTI]

the mouse wheel, and moving the mouse. To solve this problem, it is necessary to augment conventional mouse. [9] described a two-ball mouse with an additional ball to capture angular movement to provide 3DOF

Tanaka, Jiro

98

10. international mouse genome conference  

SciTech Connect (OSTI)

Ten years after hosting the First International Mammalian Genome Conference in Paris in 1986, Dr. Jean-Louis Guenet presided over the Tenth Conference at the Pasteur Institute, October 7--10, 1996. The 1986 conference was a satellite to the Human Gene Mapping Workshop and had approximately 50 attendees. The 1996 meeting was attended by 300 scientists from around the world. In the interim, the number of mapped loci in the mouse increased from 1,000 to over 20,000. This report contains a listing of the program and its participants, and two articles that review the meeting and the role of the laboratory mouse in the Human Genome project. More than 200 papers were presented at the conference covering the following topics: International mouse chromosome committee meetings; Mutant generation and identification; Physical and genetic maps; New technology and resources; Chromatin structure and gene regulation; Rate and hamster genetic maps; Informatics and databases; and Quantitative trait analysis.

Meisler, M.H.

1996-12-31T23:59:59.000Z

99

Dynamics of a drop trapped inside a horizontal circular hydraulic jump  

E-Print Network [OSTI]

A drop of moderate size deposited inside a horizontal circular hydraulic jump of the same liquid remains trapped at the shock front and does not coalesce. In this situation the drop is moving along the jump and one observes two different motions: a periodic one (it orbitates at constant speed) and an irregular one involving reversals of the orbital motion. Modeling the drop as a rigid sphere exchanging friction with liquid across a thin film of air, we recover the orbital motion and the internal rotation of the drop. This internal rotation is experimentally observed.

Duchesne, Alexis; Lebon, Luc; Pirat, Christophe; Limat, Laurent

2013-01-01T23:59:59.000Z

100

Orbits and reversals of a drop rolling inside a horizontal circular hydraulic jump  

E-Print Network [OSTI]

We explore the complex dynamics of a non-coalescing drop of moderate size inside a circular hydraulic jump of the same liquid formed on a horizontal disk. In this situation the drop is moving along the jump and one observes two different motions: a periodic one (it orbitates at constant speed) and an irregular one involving reversals of the orbital motion. Modeling the drop as a rigid sphere exchanging friction with liquid across a thin film of air, we recover the orbital motion and the internal rotation of the drop. This internal rotation is experimentally observed.

Alexis Duchesne; Clément Savaro; Luc Lebon; Christophe Pirat; Laurent Limat

2013-02-14T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Engineering steady states using jump-based feedback for multipartite entanglement generation  

SciTech Connect (OSTI)

We investigate the use of quantum-jump-based feedback to manipulate the stability of multipartite entangled dark states in an open quantum system. Using the model proposed in Phys. Rev. A 76, 010301(R) (2007) for a pair of atoms, we show a general strategy to produce many-body singlet stationary entangled states for larger number of atoms. In the case of four qubits, we propose a simple local feedback control that, although not optimal, is realistic and stabilizes a highly entangled state. We discuss the limitations and analyze alternative strategies within the framework of direct jump feedback schemes.

Stevenson, R. N.; Hope, J. J.; Carvalho, A. R. R. [Department of Quantum Sciences, Research School of Physics and Engineering, Australian National University, Canberra ACT 0200 (Australia)

2011-08-15T23:59:59.000Z

102

Analysis and improvements of fringe jump corrections by electronics on the JET tokamak far infrared interferometer  

SciTech Connect (OSTI)

For the Tore Supra interferometer phase measurements, an electronics had been developed electronics using field programmable gate array processors. The embedded algorithm can correct the fringe jumps. For comparison, the electronics ran at JET during the 2009 campaign. The first analysis concluded that the electronics was not correcting all the fringe jumps. An analysis of the failures led to improvements in the algorithm, which was tested during the rest of the campaign. In this article, we evaluate the increases in the performance. From the analysis of the remaining faults, further improvements are discussed for designing future boards that are foreseen for JET using the second wavelength and the Cotton-Mouton effect information.

Gil, C.; Barbuti, A.; Spuig, P. [IRFM, CEA, F-13108 Saint-Paul-lez-Durance (France); Boboc, A.; Dorling, S. [Culham Science Centre, EURATOM-CCFE Fusion Association, Abingdon, Oxon OX14 3DB (United Kingdom); Collaboration: JET EFDA Contributors

2010-10-15T23:59:59.000Z

103

Administration Marks Meadow  

E-Print Network [OSTI]

MULLINS CENTER FINE ARTS CENTER Boyden Gym Hills Totman Gym Melville Emerson Knowles Leach Forest & Parks Bldg Dwight Clark Thoreau Butterfield Mahar Auditorium AVENUE GOVERNORS DRIVE STO C K B R ID GE ROAD CLARK HILL RD EASTPLEASANTSTREET FEARING STREET

Massachusetts at Amherst, University of

104

Jump conditions and dynamic surface tension at permeable interfaces such as the inner core boundary  

E-Print Network [OSTI]

Jump conditions and dynamic surface tension at permeable interfaces such as the inner core boundary as the density and viscosity changes. Independently of any intrinsic surface tension, a dynamic surface tension, a possibly anisotropic surface tension and terms including an interface mass density. In pratice

105

Stochastic Models of Energy Commodity Prices and Their Applications: Mean-reversion with Jumps and  

E-Print Network [OSTI]

PWP-073 Stochastic Models of Energy Commodity Prices and Their Applications: Mean.ucei.berkeley.edu/ucei #12;Stochastic Models of Energy Commodity Prices and Their Applications: Mean-reversion with Jumps-switching and stochastic volatility into these models in order to capture the salient features of energy commodity prices

California at Berkeley. University of

106

Numerical Solution of Two Asset Jump Diffusion Models for Option Valuation  

E-Print Network [OSTI]

Numerical Solution of Two Asset Jump Diffusion Models for Option Valuation Simon S. Clift and Peter parabolic partial integro-differential equation (PIDE). An implicit, finite difference method is derived with an FFT. The method prices both American and European style contracts indepen- dent (under some simple

Forsyth, Peter A.

107

May 31, 2007 ON THE TRIPLE JUMP OF THE SET OF ATOMS OF A  

E-Print Network [OSTI]

May 31, 2007 ON THE TRIPLE JUMP OF THE SET OF ATOMS OF A BOOLEAN ALGEBRA. ANTONIO MONTALB´AN Abstract. We prove the following result about the degree spectrum of the atom relation on a computable Boolean algebra. Let C be a computable Boolean algebra with infinitely many atoms and a be the Turing

Montalbán, Antonio

108

Rank Tests for the Observability of Discrete-Time Jump Linear Systems with Inputs  

E-Print Network [OSTI]

Rank Tests for the Observability of Discrete-Time Jump Linear Systems with Inputs Ehsan Elhamifar of rank tests on the parameters of the JLS when the discrete state sequence is arbitrary. Our key verify observ- ability by checking a number of rank tests that is only quadratic in the number

109

Variation, jumps, market frictions and high frequency data in financial econometrics  

E-Print Network [OSTI]

Variation, jumps, market frictions and high frequency data in financial econometrics Ole E the econometrics of non-parametric estimation of the components of the variation of asset prices. This very active and order books. In our view the interaction of the new data sources with new econometric methodology

Wolfe, Patrick J.

110

Econometrics of testing for jumps in financial economics using bipower variation  

E-Print Network [OSTI]

Econometrics of testing for jumps in financial economics using bipower variation Ole E. Barndorff management and asset allocation. A stream of recent papers in financial econometrics has addressed this issue of quadratic variation to the increments of the risk premium. The re- cent econometric work on this topic

Wolfe, Patrick J.

111

Jump conditions for unsteady small perturbations at fluid-solid interfaces in the  

E-Print Network [OSTI]

are validated with exact conditions derived from a direct linearization of the standard jump conditions. For a straightforward comparison between both approaches, all conditions are writ- ten in terms of a curvilinear (turbomachinery com- ponents, heat exchangers, jet pumps, nuclear reactors,...) and fluid-filled cav- ities

Paris-Sud XI, Université de

112

Seismic signals are crucial for male mating success in a visual specialist jumping spider (Araneae: Salticidae)  

E-Print Network [OSTI]

Seismic signals are crucial for male mating success in a visual specialist jumping spider (Araneae of multicomponent seismic courtship signals in addition to and produced in concert with its multiple visual ornaments and movement displays. Here, we demonstrate the importance of these seismic signals

Hoy, Ronald R.

113

Simple Heuristic Derivation of the Universal Jump in the Superfluid Density of 2-Dimensional Superfluids  

E-Print Network [OSTI]

A simple heuristic derivation is given for the universal jump in the superfluid density rho(s) at the transition temperature T(c) of a two-dimensional superfluid. It is based on the mathematical equivalence of the Hamiltonians of two systems: (i) a...

Hu, Chia-Ren.

1992-01-01T23:59:59.000Z

114

Contrib. Plasma Phys. 26 (1986) 1, 1-12 Sudden Jumps, Hysteresis, and Negative Resistance  

E-Print Network [OSTI]

are found in glow discharges, carbon arcs, thermionic converters, fluorescent lamps and four-layer diodes [lContrib. Plasma Phys. 26 (1986) 1, 1-12 Sudden Jumps, Hysteresis, and Negative Resistance in an Argon Plasma Discharge I. Discharges with No Magnetic Field R. A. BOSCHand R. L. MERLINO Department

Merlino, Robert L.

115

Jumping solitary waves in an autonomous reactiondiffusion system with subcritical wave instability  

E-Print Network [OSTI]

Jumping solitary waves in an autonomous reaction­diffusion system with subcritical wave instability as solutions to a reaction­diffusion system with a subcritical short-wavelength instability. We demonstrate systems with a subcritical oscillatory instability.17 Here we present a new type of solitary traveling

Epstein, Irving R.

116

Automated high pressure cell for pressure jump x-ray diffraction  

SciTech Connect (OSTI)

A high pressure cell for small and wide-angle x-ray diffraction measurements of soft condensed matter samples has been developed, incorporating a fully automated pressure generating network. The system allows both static and pressure jump measurements in the range of 0.1-500 MPa. Pressure jumps can be performed as quickly as 5 ms, both with increasing and decreasing pressures. Pressure is generated by a motorized high pressure pump, and the system is controlled remotely via a graphical user interface to allow operation by a broad user base, many of whom may have little previous experience of high pressure technology. Samples are loaded through a dedicated port allowing the x-ray windows to remain in place throughout an experiment; this facilitates accurate subtraction of background scattering. The system has been designed specifically for use at beamline I22 at the Diamond Light Source, United Kingdom, and has been fully integrated with the I22 beamline control systems.

Brooks, Nicholas J.; Gauthe, Beatrice L. L. E.; Templer, Richard H.; Ces, Oscar; Seddon, John M. [Department of Chemistry, Imperial College London, South Kensington Campus, London SW7 2AZ (United Kingdom); Terrill, Nick J. [Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE (United Kingdom); Rogers, Sarah E. [ISIS, Rutherford Appleton Laboratory, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0QX (United Kingdom)

2010-06-15T23:59:59.000Z

117

Quantum Jump Approach to Switching Process of a Josephson Junction Coupled to a Microscopic Two-Level System  

E-Print Network [OSTI]

With microwave irradiation, the switching current of a Josephson junction coupled to a microscopic two-level system jumps randomly between two discrete states. We modeled the switching process of the coupled system with quantum jump approach that was generally used in quantum optics. The parameters that affect the character of the quantum jumps between macroscopic quantum states are discussed. The results obtained from our theoretical analysis agree well with those of the experiments and provide a clear physical picture for the macroscopic quantum jumps in Josephson junctions coupled with two-level systems. In addition, quantum jumps may serve as a useful tool to investigate the microscopic two-level structures in solid-state systems.

Xueda Wen; Yiwen Wang; Ning Dong; Guozhu Sun; Jian Chen; Lin Kang; Weiwei Xu; Peiheng Wu; Yang Yu

2009-07-14T23:59:59.000Z

118

Characterization of the Mouse Brain Proteome Using Global Proteomic...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the Mouse Brain Proteome Using Global Proteomic Analysis Complemented with Cysteinyl-Peptide Enrichment. Characterization of the Mouse Brain Proteome Using Global Proteomic...

119

Jump chaotic behaviour of ultra low loss bulk acoustic wave cavities  

SciTech Connect (OSTI)

We demonstrate a previously unobserved nonlinear phenomenon in an ultra-low loss quartz bulk acoustic wave cavity (Q>3>10{sup 9}), which only occurs below 20 mK in temperature and under relatively weak pumping. The phenomenon reveals the emergence of several stable equilibria (at least two foci and two nodes) and jumps between these quasi states at random times. The degree of this randomness as well as separations between levels can be controlled by the frequency of the incident carrier signal. It is demonstrated that the nature of the effect lies beyond the standard Duffing model.

Goryachev, Maxim, E-mail: maxim.goryachev@uwa.edu.au; Farr, Warrick G.; Tobar, Michael E. [ARC Centre of Excellence for Engineered Quantum Systems, University of Western Australia, 35 Stirling Highway, Crawley WA 6009 (Australia); Galliou, Serge [Department of Time and Frequency, FEMTO-ST Institute, ENSMM, 26 Chemin de l'Épitaphe 25000 Besançon (France)

2014-08-11T23:59:59.000Z

120

A cinematographical analysis of the action of the lead leg in the flop high jump  

E-Print Network [OSTI]

-knee trial 49 52 63 64 67 68 73 75 CHAPTER I INTRODUCTION The gold medal performance at the 1968 Olympic Games by Dick Fosbury of 2. 24 m introduced the flop high jump to the world. Named for it's innovator, the Fosbury flop is characterized by a... high jumpers for the Elite Athlete program co- sponsored by the United States Olympic Committee and The Athletics Congress. Filming took place at the 1983 Houston Invitational and the 1983 Athletics Congress Championships in Indianapolis. Two high...

Smith, Carol J

2012-06-07T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Lyme disease in an experimental mouse model  

E-Print Network [OSTI]

Antibody response, using RIA, to Borrelia burgdorferi B31 isolate in sera from C3H/HeJ strain mice, at a 1;10 dilution, following seven different routes of inoculation. . . . . Page 29 2 C3H/HeJ mouse showing arthus type reaction, 24 hours post intra..., 15 days post injection. . . , 5 Antibody Response, using RIA, to homologous Borrelia hurgdorferi isolates in sera from C3H/HeJ mouse strains, at a 1:10 serum dilution of 5 tail bleeds. . . . . . 34 37 6. C3H/HeJ mouse showing granulomatous skin...

Reddy, Sunitha

1993-01-01T23:59:59.000Z

122

A parametric study of shock jump chemistry, electron temperature, and radiative heat transfer models in hypersonic flows  

E-Print Network [OSTI]

A PARAMETRIC STUDY OF SHOCK JUMP CHEMISTRY, ELECTRON TEMPERATURE, AND RADIATIVE HEAT TRANSFER MODELS IN HYPERSONIC FLOWS A Thesis by ROBERT BRIAN GREENDYKE Submitted to the Graduate College of Texas A&M University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE August 1988 Major Subject: Aerospace Engineering A PARAMETRIC STUDY OF SHOCK JUMP CHEMISTRY, ELECTRON TEMPERATURE, AND RADIATIVE HEAT TRANSFER MODELS IN HYPERSONIC FLOWS A Thesis by ROBERT BRIAN...

Greendyke, Robert Brian

2012-06-07T23:59:59.000Z

123

A Hidden Markov Model of atomic quantum jump dynamics in an optically probed cavity  

E-Print Network [OSTI]

We analyze the quantum jumps of an atom interacting with a cavity field. The strong atom- field interaction makes the cavity transmission depend on the time dependent atomic state, and we present a Hidden Markov Model description of the atomic state dynamics which is conditioned in a Bayesian manner on the detected signal. We suggest that small variations in the observed signal may be due to spatial motion of the atom within the cavity, and we represent the atomic system by a number of hidden states to account for both the small variations and the internal state jump dynamics. In our theory, the atomic state is determined in a Bayesian manner from the measurement data, and we present an iterative protocol, which determines both the atomic state and the model parameters. As a new element in the treatment of observed quantum systems, we employ a Bayesian approach that conditions the atomic state at time t on the data acquired both before and after t and we show that the state assignment by this approach is more decisive than the usual conditional quantum states, based on only earlier measurement data.

S. Gammelmark; W. Alt; T. Kampschulte; D. Meschede; K. Molmer

2014-05-02T23:59:59.000Z

124

X-Ray cavities and temperature jumps in strong cool core cluster Abell 2390  

E-Print Network [OSTI]

We present results based on the systematic analysis of high resolution 95\\,ks \\textit{Chandra} observations of the strong cool core cluster Abell 2390 at the redshift of z = 0.228, which hosts an energetic radio AGN. This analysis has enabled us to investigate five X-ray deficient cavities in the hot atmosphere of Abell 2390 within central 30\\arcsec, three of which are newly detected. Presence of these cavities have been confirmed through a various image processing techniques like, the surface brightness profiles, unsharp masked image, as well as 2D elliptical model subtracted residual map. Temperature profile as well as 2D temperature map revealed structures in the distribution of ICM, in the sense that ICM in NW direction is relatively cooler than that on the SE direction. Two temperature jumps, one from 6\\,keV to 9.25\\,keV at 72 kpc on the north direction, and the other from 6\\,keV to 10.27\\,keV at 108 kpc in the east direction have been observed. These temperature jumps are associated with the shocks with...

Sonkamble, S S; Pawar, P K; Patil, M K

2014-01-01T23:59:59.000Z

125

The jump-off velocity of an impulsively loaded spherical shell  

SciTech Connect (OSTI)

We consider a constant temperature spherical shell of isotropic, homogeneous, linearly elastic material with density {rho} and Lame coefficients {lambda} and {mu}. The inner and outer radii of the shell are r{sub i} and r{sub o}, respectively. We assume that the inside of the shell is a void. On the outside of the shell, we apply a uniform, time-varying pressure p(t). We also assume that the shell is initially at rest. We want to compute the jump-off time and velocity of the pressure wave, which are the first time after t = 0 at which the pressure wave from the outer surface reaches the inner surface. This analysis computes the jump-off velocity and time for both compressible and incompressible materials. This differs substantially from [3], where only incompressible materials are considered. We will consider the behavior of an impulsively loaded, exponentially decaying pressure wave p(t) = P{sub 0{sup e}}{sup -{alpha}t}, where {alpha} {ge} 0. We notice that a constant pressure wave P(t) = P{sub 0} is a special case ({alpha} = 0) of a decaying pressure wave. Both of these boundary conditions are considered in [3].

Chabaud, Brandon M. [Los Alamos National Laboratory; Brock, Jerry S. [Los Alamos National Laboratory

2012-04-13T23:59:59.000Z

126

Materials Science and Engineering A 423 (2006) 2427 Experimental and computational study on the load-jump tests of AlMg  

E-Print Network [OSTI]

) comparison of indentation creep curve (ICC) right after load jumping and that for the corresponding constant-load on the load-jump tests of Al­Mg solid­solution alloy using instrumented indentation technique H. Takagia,, M January 2006 Abstract Constant-load tests and load-jump tests were carried out using a microindenter in Al

Dao, Ming

2006-01-01T23:59:59.000Z

127

Dazl regulates mouse embryonic germ cell development  

E-Print Network [OSTI]

In the mouse, germ cells can undergo differentiation to become either oocytes or spermatozoa in response to sex of their gonadal environment. The nature of the germ cell-intrinsic aspects of this signaling have not been ...

Gill, Mark E

2010-01-01T23:59:59.000Z

128

Jump in fluid properties of inflationary universe to reconcile scalar and tensor spectra  

E-Print Network [OSTI]

The recent detection of the primordial gravitational waves from the BICEP2 observation seems to be in tension with the upper bound on the amplitude of tensor perturbations from the PLANCK data. We consider a phenomenological model of inflation in which the microscopical properties of the inflationary fluid such as the equation of state $w$ or the sound speed $c_s$ jump in a sharp manner. We show that the amplitude of the scalar perturbations is controlled by a non-trivial combination of $w$ and $c_s$ before and after the phase transition while the tensor perturbations remains nearly intact. With an appropriate choice of the fluid parameters $w$ and $c_s$ one can suppress the scalar perturbation power spectrum on large scales to accommodate a large tensor amplitude with $r=0.2$ as observed by BICEP2 observation.

Hassan Firouzjahi; Mohammad Hossein Namjoo

2014-04-09T23:59:59.000Z

129

Limiting results for the free energy of directed polymers in random environment with unbounded jumps  

E-Print Network [OSTI]

We study asymptotic behaviors of the free energy for the directed polymer in random environment. The polymer is allowed to make unbounded jumps and the environment is given by the Bernoulli variables. We first establish the existence and continuity including the negative infinity value of the coupling constant $\\beta$. Our proof of existence at $\\beta=-\\infty$ differs from existing ones in that it avoids the direct use of subadditivity. Secondly, we identify the asymptotics of the free energy at $\\beta=-\\infty$ in the limit of the success probability of the Bernoulli variables tending to one. It is described by using the so-called time constant of a certain directed first passage percolation. Our proof relies on a certain continuity property of the time constant, which is of independent interest.

Francis Comets; Ryoki Fukushima; Shuta Nakajima; Nobuo Yoshida

2015-04-17T23:59:59.000Z

130

Reversible jump Markov chain Monte Carlo computation and Bayesian model determination  

E-Print Network [OSTI]

Markov chain Monte Carlo methods for Bayesian computation have until recently been restricted to problems where the joint distribution of all variables has a density with respect to some xed standard underlying measure. They have therefore not been available for application to Bayesian model determination, where the dimensionality of the parameter vector is typically not xed. This article proposes a new framework for the construction of reversible Markov chain samplers that jump between parameter subspaces of di ering dimensionality, which is exible and entirely constructive. It should therefore have wide applicability in model determination problems. The methodology is illustrated with applications to multiple change-point analysis in one and two dimensions, and toaBayesian comparison of binomial experiments.

Peter J. Green

1995-01-01T23:59:59.000Z

131

Decoherent time-dependent transport beyond Landauer-Büttiker: a Quantum Drift alternative to Quantum Jumps  

E-Print Network [OSTI]

We present a model for decoherence in time-dependent transport. It boils down into a form of wave function that undergoes a smooth stochastic drift of the phase in a local basis, the Quantum Drift (QD) model. This drift is nothing else but a local energy fluctuation. Unlike Quantum Jumps (QJ) models, no jumps are present in the density as the evolution is unitary. As a first application, we address the transport through a resonant state $\\left\\vert 0\\right\\rangle $ that undergoes decoherence. We show the equivalence with the decoherent steady state transport in presence of a B\\"{u}ttiker's voltage probe. In order to test the dynamics, we consider two many-spin systems whith a local energy fluctuation. A two-spin system is reduced to a two level system (TLS) that oscillates among $\\left\\vert 0\\right\\rangle $ $\\equiv $ $ \\left\\vert \\uparrow \\downarrow \\right\\rangle $ and $\\left\\vert 1\\right\\rangle \\equiv $ $\\left\\vert \\downarrow \\uparrow \\right\\rangle $. We show that QD model recovers not only the exponential damping of the oscillations in the low perturbation regime, but also the non-trivial bifurcation of the damping rates at a critical point, i.e. the quantum dynamical phase transition. We also address the spin-wave like dynamics of local polarization in a spin chain. The QD average solution has about half the dispersion respect to the mean dynamics than QJ. By evaluating the Loschmidt Echo (LE), we find that the pure states $\\left\\vert 0\\right\\rangle $ and $\\left\\vert 1\\right \\rangle $ are quite robust against the local decoherence. In contrast, the LE, and hence coherence, decays faster when the system is in a superposition state. Because its simple implementation, the method is well suited to assess decoherent transport problems as well as to include decoherence in both one-body and many-body dynamics.

Lucas J. Fernández-Alcázar; Horacio M. Pastawski

2015-01-26T23:59:59.000Z

132

Construction of Anatomically Correct Models of Mouse Brain Networks 1  

E-Print Network [OSTI]

Construction of Anatomically Correct Models of Mouse Brain Networks 1 B. H. McCormick a, W. Koh a Y and Public Health, Texas A&M University, 4458 TAMU, College Station, TX 77843-4458 Abstract The Mouse Brain Web, a federated database, provides for the construction of anatomically correct models of mouse brain

Keyser, John

133

Bayesian analysis of GARCH and stochastic volatility: modeling leverage, jumps and heavy-tails for financial time series  

E-Print Network [OSTI]

Bayesian analysis of GARCH and stochastic volatility: modeling leverage, jumps and heavy for two broad major classes of varying volatility model, GARCH and stochastic volatility (SV) models-t errors yields the best performance among the competing models on the return data. Key words: GARCH, Heavy

Wolpert, Robert L

134

A Numerical Method for Pricing Electricity Derivatives for Jump-Diffusion Processes Based on Continuous Time Lattices  

E-Print Network [OSTI]

A Numerical Method for Pricing Electricity Derivatives for Jump-Diffusion Processes Based.tompaidis@mccombs.utexas.edu Corresponding author. Tel. 512-4715252, Fax 512-4710587. #12;A Numerical Method for Pricing Electricity method for pricing derivatives on electricity prices. The method is based on approximating the generator

Albanese, Claudio

135

Where Did All the Money Go? Congress approved the Troubled Asset Relief Program (TARP) to jump start the credit  

E-Print Network [OSTI]

Where Did All the Money Go? Congress approved the Troubled Asset Relief Program (TARP) to jump forward that unfortunately remains vague. Inexplicably, the TARP II money did not come with a mandate to use the money to increase lending. Now, covenants come with the distribution of the remaining TARP

Ahmad, Sajjad

136

Hydraulic jumps on an incline J E A N L U C T H I F F E A U L T1,2  

E-Print Network [OSTI]

1 Hydraulic jumps on an incline J E A N ­ L U C T H I F F E A U L T1,2 AND A N D R E W B E L M O N rim resembling a parabola and reminiscent of a hydraulic jump. There appears to be little theory, and present a simple theory based on horizontal hydraulic jumps which accounts for the rise height and its

137

Structural Differences Mouse-over highlighting shows  

E-Print Network [OSTI]

regions accordingly · See individual nucleotides in the context· See individual nucleotides in the context· See individual nucleotides in the context· See individual nucleotides in the context of a sequence Finding motifs · Interactive mouse-over highlighting · Search for nucleotide or codon strings · Simple

Munzner, Tamara

138

"Granular jets and hydraulic jumps on an inclined plane", C. G. Johnson, J. M. N. T. Gray ( ), J. Fluid Mech., (Submitted)  

E-Print Network [OSTI]

indicates the parameters for which teardrop-shaped shocks (Ã?), blunted shocks (), steady subcritical , with supercritical ow (Fr > 1) marked in red/yellow, and subcritical ow (Fr a discontinuity in ow height and velocity, analogous to a hydraulic jump in shallow-water ow. is steady jump takes

Heil, Matthias

139

Steel characteristics measurement system using Barkhausen jump sum rate and magnetic field intensity and method of using same  

DOE Patents [OSTI]

A steel hardness measurement system and method of using same are provided for measuring at least one mechanical or magnetic characteristic of a ferromagnetic sample as a function of at least one magnetic characteristic of the sample. A magnetic field generator subjects the sample to a variable external magnetic field. The magnetic field intensity of the magnetic field generated by the magnetic field generating means is measured and a signal sensor is provided for measuring Barkhausen signals from the sample when the sample is subjected to the external magnetic field. A signal processing unit calculates a jump sum rate first moment as a function of the Barkhausen signals measured by the signal sensor and the magnetic field intensity, and for determining the at least one mechanical or magnetic characteristic as a function of the jump sum rate first moment.

Kohn, Gabriel (Omer, IL); Hicho, George (Derwood, MD); Swartzendruber, Lydon (New Carrollton, MD)

1997-01-01T23:59:59.000Z

140

Steel characteristics measurement system using Barkhausen jump sum rate and magnetic field intensity and method of using same  

DOE Patents [OSTI]

A steel hardness measurement system and method of using same are provided for measuring at least one mechanical or magnetic characteristic of a ferromagnetic sample as a function of at least one magnetic characteristic of the sample. A magnetic field generator subjects the sample to a variable external magnetic field. The magnetic field intensity of the magnetic field generated by the magnetic field generating means is measured and a signal sensor is provided for measuring Barkhausen signals from the sample when the sample is subjected to the external magnetic field. A signal processing unit calculates a jump sum rate first moment as a function of the Barkhausen signals measured by the signal sensor and the magnetic field intensity, and for determining the at least one mechanical or magnetic characteristic as a function of the jump sum rate first moment. 7 figs.

Kohn, G.; Hicho, G.; Swartzendruber, L.

1997-04-08T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

alters mouse behavior: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

(such as action-selection processes) provide script languages Ouhyoung, Ming 8 Mouse behavior recognition with the wisdom of crowd MIT - DSpace Summary: In this thesis, we...

142

Neutron issues in the JANUS mouse program  

SciTech Connect (OSTI)

Over the last 25 years, the JANUS program in the Biological and Medical Research Division at Argonne National Laboratory (ANL) has compiled a database on the response of both sexes of an F{sub 1} hybrid mouse, the B6CF{sub 1} (C57BL/6 x BALB/c), to external whole- body irradiation by {sup 60}Co {gamma}-rays and fission neutrons. Three basic patterns of exposure for both neutrons and {gamma}-rays have been investigated: single exposures, 24 equal once-weekly exposures, and 60 equal once-weekly exposures. All irradiations were terminated at predetermined total doses, with dose calculated in centigrays at the midline of the mouse. Three endpoints will be discussed in this paper: (1) life shortening, (2) a point estimate for cumulative mortality, and (3) the hazard function. Life shortening is used as an analysis endpoint because it summarizes, in a single index, the integrated effect of all injuries accumulated by an organism. Histopathological analyses of the mice used in the ANL studies have indicated that 85% of the deaths were caused by neoplasms. Connective tissue tumors were the dominant tumor in the B6CF{sub 1} mouse, with tumors of lymphoreticular origin accounting for approximately 80% of this class. The latter two endpoints will therefore be used to describe the life table experience of mice dying from the lymphoreticular class of tumors. Dose-response models will be applied to the three endpoints in order to describe the response function for neutron exposures, evaluate the effect of dose range and pattern of exposure on the response function for neutrons, and provide a set of neutron relative biological effectiveness (RBE) values of the ANL database. 25 refs.

Carnes, B.A.; Grahn, D.

1990-01-01T23:59:59.000Z

143

E-Print Network 3.0 - adult mouse white Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

mouse white Search Powered by Explorit Topic List Advanced Search Sample search results for: adult mouse white Page: << < 1 2 3 4 5 > >> 1 Boston University Computer Science...

144

Spatial Mapping of Protein Abundances in the Mouse Brain by Voxelation...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mapping of Protein Abundances in the Mouse Brain by Voxelation Integrated with High-Throughput Liquid Chromatography Spatial Mapping of Protein Abundances in the Mouse Brain by...

145

COS DCE BOOT FSW v1.09 Component Test Results Requirement 5.2.4.1 Command to Jump Anywhere in Code  

E-Print Network [OSTI]

COS DCE BOOT FSW v1.09 Component Test Results Requirement 5.2.4.1 Command to Jump Anywhere in Code. Brownsberger 2-13-01 The Center for Astrophysics and Space Astronomy Reviewed: Approved: COS DCE BOOT FSW v1 Astronomy Initial Release COS DCE BOOT FSW v1.09 Component Test Results Requirement 5.2.4.1 Command to Jump

Colorado at Boulder, University of

146

COS DCE BOOT FSW v1.13 Component Test Results Requirement 5.2.4.1 Command to Jump Anywhere in Code  

E-Print Network [OSTI]

COS DCE BOOT FSW v1.13 Component Test Results Requirement 5.2.4.1 Command to Jump Anywhere in Code. Brownsberger 2-13-01 The Center for Astrophysics and Space Astronomy Reviewed: Approved: COS DCE BOOT FSW v1 Astronomy Initial Release COS DCE BOOT FSW v1.13 Component Test Results Requirement 5.2.4.1 Command to Jump

Colorado at Boulder, University of

147

An Efficient Quantum Jump Method for Coherent Energy Transfer Dynamics in Photosynthetic Systems under the Influence of Laser Fields  

E-Print Network [OSTI]

We present a non-Markovian quantum jump approach for simulating coherent energy transfer dynamics in molecular systems in the presence of laser fields. By combining a coherent modified Redfield theory (CMRT) and a non-Markovian quantum jump (NMQJ) method, this new approach inherits the broad-range validity from the CMRT and highly efficient propagation from the NMQJ. To implement NMQJ propagation of CMRT, we show that the CMRT master equation can be casted into a generalized Lindblad form. Moreover, we extend the NMQJ approach to treat time-dependent Hamiltonian, enabling the description of excitonic systems under coherent laser fields. As a benchmark of the validity of this new method, we show that the CMRT-NMQJ method accurately describes the energy transfer dynamics in a prototypical photosynthetic complex. Finally, we apply this new approach to simulate the quantum dynamics of a dimer system coherently excited to coupled single-excitation states under the influence of laser fields, which allows us to investigate the interplay between the photoexcitation process and ultrafast energy transfer dynamics in the system. We demonstrate that laser-field parameters significantly affect coherence dynamics of photoexcitations in excitonic systems, which indicates that the photoexcitation process must be explicitly considered in order to properly describe photon-induced dynamics in photosynthetic systems. This work should provide a valuable tool for efficient simulations of coherent control of energy flow in photosynthetic systems and artificial optoelectronic materials.

Qing Ai; Yuan-Jia Fan; Bih-Yaw Jin; Yuan-Chung Cheng

2014-04-19T23:59:59.000Z

148

Laser-induced temperature jump/time-resolved infrared study of the fast events in protein folding  

SciTech Connect (OSTI)

Laser-induced temperature jump followed by time-resolved infrared probe of reaction dynamics are used to study the temporal evolution of polypeptide structure during protein folding and unfolding. Reactions are initiated in times of 50 ps or longer by T-jumps of 10`s of degrees, obtained by laser excitation of water overtone absorbances. Observation of the Amide I transient absorbances reveal melting lifetimes of helices unconstrained by tertiary structure to be ca. 160 ns in a model 21-peptide and ca. 30 ns in {open_quotes}molten globule{close_quotes} apomyoglobin. No other processes are observed in these systems over the timescale 50 ps to 2 ms. Equilibrium data suggest the corresponding helix formation lifetimes to be ca. 16 and 1 ns, respectively. In {open_quotes}native{close_quotes} apomyoglobin two helix melting lifetimes are observed and we infer that a third occurs on a timescale inaccessible to our experiment (> 1 ms). The shorter observed lifetime, as in the molten globule, is ca. 30 ns. The longer lifetime is ca. 70 {mu}s. We suggest that the slower process is helix melting that is rate-limited by the unfolding of tertiary structure. Equilibrium data suggest a lifetime of ca. 1 {mu}s for the development of these tertiary folds.

Woodruff, W.H.; Dyer, R.B.; Williams, S. [Los Alamos National Laboratory, NM (United States); Callender, H.; Gilmanshin, R. [CUNY, NY (United States)

1996-10-01T23:59:59.000Z

149

Probing the mechanism of rubredoxin thermal unfolding in the absence of salt bridges by temperature jump experiments  

SciTech Connect (OSTI)

Rubredoxins are the simplest type of iron-sulphur proteins and in recent years they have been used as model systems in protein folding and stability studies, especially the proteins from thermophilic sources. Here, we report our studies on the rubredoxin from the hyperthermophile Methanococcus jannaschii (T {sub opt} = 85 deg C), which was investigated in respect to its thermal unfolding kinetics by temperature jump experiments. Different spectroscopic probes were used to monitor distinct structural protein features during the thermal transition: the integrity of the iron-sulphur centre was monitored by visible absorption spectroscopy, whereas tertiary structure was followed by intrinsic tryptophan fluorescence and exposure of protein hydrophobic patches was sensed by 1-anilinonaphthalene-8-sulphonate fluorescence. The studies were performed at acidic pH conditions in which any stabilising contributions from salt bridges are annulled due to protonation of protein side chain groups. In these conditions, M. jannaschii rubredoxin assumes a native-like, albeit more flexible and open conformation, as indicated by a red shift in the tryptophan emission maximum and 1-anilinonaphthalene-8-sulphonate binding. Temperature jumps were monitored by the three distinct techniques and showed that the protein undergoes thermal denaturation via a simple two step mechanism, as loss of tertiary structure, hydrophobic collapse, and disintegration of the iron-sulphur centre are concomitant processes. The proposed mechanism is framed with the multiphasic one proposed for Pyrococcus furiosus rubredoxin, showing that a common thermal unfolding mechanism is not observed between these two closely related thermophilic rubredoxins.

Henriques, Barbara J. [Instituto Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras (Portugal); Saraiva, Ligia M. [Instituto Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras (Portugal); Gomes, Claudio M. [Instituto Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras (Portugal)]. E-mail: gomes@itqb.unl.pt

2005-08-05T23:59:59.000Z

150

Decoherent time-dependent transport beyond the Landauer-Büttiker formulation: a quantum-drift alternative to quantum jumps  

E-Print Network [OSTI]

We present a model for decoherence in time-dependent transport. It boils down into a form of wave function that undergoes a smooth stochastic drift of the phase in a local basis, the Quantum Drift (QD) model. This drift is nothing else but a local energy fluctuation. Unlike Quantum Jumps (QJ) models, no jumps are present in the density as the evolution is unitary. As a first application, we address the transport through a resonant state $\\left\\vert 0\\right\\rangle $ that undergoes decoherence. We show the equivalence with the decoherent steady state transport in presence of a B\\"{u}ttiker's voltage probe. In order to test the dynamics, we consider two many-spin systems whith a local energy fluctuation. A two-spin system is reduced to a two level system (TLS) that oscillates among $\\left\\vert 0\\right\\rangle $ $\\equiv $ $ \\left\\vert \\uparrow \\downarrow \\right\\rangle $ and $\\left\\vert 1\\right\\rangle \\equiv $ $\\left\\vert \\downarrow \\uparrow \\right\\rangle $. We show that QD model recovers not only the exponential damping of the oscillations in the low perturbation regime, but also the non-trivial bifurcation of the damping rates at a critical point, i.e. the quantum dynamical phase transition. We also address the spin-wave like dynamics of local polarization in a spin chain. The QD average solution has about half the dispersion respect to the mean dynamics than QJ. By evaluating the Loschmidt Echo (LE), we find that the pure states $\\left\\vert 0\\right\\rangle $ and $\\left\\vert 1\\right \\rangle $ are quite robust against the local decoherence. In contrast, the LE, and hence coherence, decays faster when the system is in a superposition state. Because its simple implementation, the method is well suited to assess decoherent transport problems as well as to include decoherence in both one-body and many-body dynamics.

Lucas J. Fernández-Alcázar; Horacio M. Pastawski

2015-02-27T23:59:59.000Z

151

Mouse Pointing Endpoint Prediction Using Kinematic Template Matching  

E-Print Network [OSTI]

Mouse Pointing Endpoint Prediction Using Kinematic Template Matching Phillip T. Pasqual and Jacob O and that copies bear this notice and the full citation on the first page. Copyrights for components of this work

Wobbrock, Jacob O.

152

Characterization of the mouse pancreatic islet proteome and comparative analysis with other mouse tissues  

SciTech Connect (OSTI)

The pancreatic islets of Langerhans and insulin-producing beta cells in particular play a central role in the maintenance of glucose homeostasis and the islet dysfunction is associated with the pathogenesis of both type 1 and type 2 diabetes mellitus. To contribute to the understanding of the biology of the pancreatic islets we applied proteomic techniques based on liquid chromatography coupled with mass spectrometry. Here as an initial step we present the first comprehensive proteomic characterization of pancreas islets of the mouse, the commonly used animal model for diabetes research. Two-dimensional SCX LC/RP LC-MS/MS has been applied to characterize of the mouse islet proteome, resulting in the confident identification of 17,350 different tryptic peptides covering 2,612 proteins with at least two unique peptide identifications per protein. The dataset also allowed identification of a number of post-translational modifications including several modifications relevant to oxidative stress and phosphorylation. While many of the identified phosphorylation sites corroborates with previous known sites, the oxidative modifications observed on cysteinyl residues potentially reveal novel information related to the role of oxidation stress in islet functions. Comparative analysis of the islet proteome database with 15 available proteomic datasets from other mouse tissues and cells revealed a set of 68 proteins uniquely detected only in the pancreatic islets. Besides proteins with known functions, like islet secreted peptide hormones, this unique set contains a number of proteins with yet unknown functions. The resulting peptide and protein database will be available at ncrr.pnl.gov web site of the NCRR proteomic center (ncrr.pnl.gov).

Petyuk, Vladislav A.; Qian, Weijun; Hinault, Charlotte; Gritsenko, Marina A.; Singhal, Mudita; Monroe, Matthew E.; Camp, David G.; Kulkarni, Rohit N.; Smith, Richard D.

2008-08-01T23:59:59.000Z

153

Initial sequencing and comparative analysis of the mouse genome  

SciTech Connect (OSTI)

The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.

Waterston, Robert H.; Lindblad-Toh, Kerstin; Birney, Ewan; Rogers, Jane; Abril, Josep F.; Agarwal, Pankaj; Agarwala, Richa; Ainscough, Rachel; Alexandersson, Marina; An, Peter; Antonarakis, Stylianos E.; Attwood, John; Baertsch, Robert; Bailey, Jonathon; Barlow, Karen; Beck, Stephan; Berry, Eric; Birren, Bruce; Bloom, Toby; Bork, Peer; Botcherby, Marc; Bray, Nicolas; Brent, Michael R.; Brown, Daniel G.; Brown, Stephen D.; Bult, Carol; Burton, John; Butler, Jonathan; Campbell, Robert D.; Carninci, Piero; Cawley, Simon; Chiaromonte, Francesca; Chinwalla, Asif T.; Church, Deanna M.; Clamp, Michele; Clee, Christopher; Collins, Francis S.; Cook, Lisa L.; Copley, Richard R.; Coulson, Alan; Couronne, Olivier; Cuff, James; Curwen, Val; Cutts, Tim; Daly, Mark; David, Robert; Davies, Joy; Delehaunty, Kimberly D.; Deri, Justin; Dermitzakis, Emmanouil T.; Dewey, Colin; Dickens, Nicholas J.; Diekhans, Mark; Dodge, Sheila; Dubchak, Inna; Dunn, Diane M.; Eddy, Sean R.; Elnitski, Laura; Emes, Richard D.; Eswara, Pallavi; Eyras, Eduardo; Felsenfeld, Adam; Fewell, Ginger A.; Flicek, Paul; Foley, Karen; Frankel, Wayne N.; Fulton, Lucinda A.; Fulton, Robert S.; Furey, Terrence S.; Gage, Diane; Gibbs, Richard A.; Glusman, Gustavo; Gnerre, Sante; Goldman, Nick; Goodstadt, Leo; Grafham, Darren; Graves, Tina A.; Green, Eric D.; Gregory, Simon; Guigo, Roderic; Guyer, Mark; Hardison, Ross C.; Haussler, David; Hayashizaki, Yoshihide; Hillier, LaDeana W.; Hinrichs, Angela; Hlavina, Wratko; Holzer, Timothy; Hsu, Fan; Hua, Axin; Hubbard, Tim; Hunt, Adrienne; Jackson, Ian; Jaffe, David B.; Johnson, L. Steven; Jones, Matthew; Jones, Thomas A.; Joy, Ann; Kamal, Michael; Karlsson, Elinor K.; Karolchik, Donna; Kasprzyk, Arkadiusz; Kawai, Jun; Keibler, Evan; Kells, Cristyn; Kent, W. James; Kirby, Andrew; Kolbe, Diana L.; Korf, Ian; Kucherlapati, Raju S.; Kulbokas III, Edward J.; Kulp, David; Landers, Tom; Leger, J.P.; Leonard, Steven; Letunic, Ivica; Levine, Rosie; et al.

2002-12-15T23:59:59.000Z

154

Proteome and Transcriptome Profiles of a Her2/Neu-driven Mouse...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Transcriptome Profiles of a Her2Neu-driven Mouse Model of Breast Cancer. Proteome and Transcriptome Profiles of a Her2Neu-driven Mouse Model of Breast Cancer. Abstract: In...

155

Tandem Mass Spectrometry identifies many mouse brain O-GlcNAcylated...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Tandem Mass Spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase Tandem Mass Spectrometry identifies many mouse brain...

156

E-Print Network 3.0 - atdc5 mouse progenitor Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

con- firmed for mouse brain glia... astrocytes and the other, oligodendro- cytes. Comparison of O-2A Progenitors from Rat Optic Nerve and Mouse... and co-workers reported that...

157

Model 923-B Mouse Gas Anesthesia Head Holder Adaptor Adjustment Features  

E-Print Network [OSTI]

Model 923-B Mouse Gas Anesthesia Head Holder Adaptor Adjustment Features Dorsal/Ventral dial.352.3139 Toll Free: 1.877.352.3275 ^^ci&ion Q)e&i^n^^^r ^esea/H^/i Model 923-B Mouse Gas Anesthesia Head Holder 923B-1/07 #12;MODEL 923-B MOUSE GAS ANESTHESIA HEAD HOLDER The KOPF Mouse Gas Anesthesia Head Holder

Kleinfeld, David

158

Systematic Enhancement of Polymerization of Recombinant Sickle Hemoglobin Mutants: Implications for Transgenic Mouse Model  

E-Print Network [OSTI]

for Transgenic Mouse Model for Sickle Cell Anemia By Xianfeng Li, Urooj A. Mirza, Brian T. Chait, and James M for sisting of HbS, Hb Antilles, and Hb D-Punjab. Normal mouse sickle cell anemia, we have expressed generation of the transgenic mouse model for sickle cell and polymerized in a linear manner at progressively

Chait, Brian T.

159

Development/Plasticity/Repair Hair Cell Replacement in Adult Mouse Utricles after  

E-Print Network [OSTI]

Development/Plasticity/Repair Hair Cell Replacement in Adult Mouse Utricles after Targeted Ablation of Hair Cells with Diphtheria Toxin Justin S. Golub,1 Ling Tong,1 Tot B. Ngyuen,1 Cliff R. Hume,1 Richard developed a transgenic mouse to permit conditional and selective ablation of hair cells in the adult mouse

Rubel, Edwin

160

Zgoubi-ing AGS : spin motion with snakes and jump-quads,G? = 43.5 through G? = 46.5 and beyond  

SciTech Connect (OSTI)

This Note reports on the first, and successful, simulations of particle and spin dynamics in the AGS in presence of the two helical snakes and of the tune-jump quadrupoles, using the ray-tracing code Zgoubi. It includes DA tracking in the absence or in the presence of the two helical snakes, simulation of particle and spin motion in the snakes using their magnetic field maps, spin flipping at integer resonances in the 36+Qy depolarizing resonance region, with and without tune-jump quadrupole gymnastics. It also includes details on the setting-up of Zgoubi input data files and on the various numerical methods of concern in and available from Zgoubi.

Meot F.; Ahrens& #44; L.; Glenn& #44; J.; Huang& #44; H.; Luccio& #44; A.; MacKay& #44; W.W.; Roser& #44; T.; Tsoupas& #44; N.

2009-10-01T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Mouse inbred strain differences in ethanol drinking to intoxication  

E-Print Network [OSTI]

Mouse inbred strain differences in ethanol drinking to intoxication J. S. Rhodes*, , M. M. Ford , C described a simple procedure, Drinking in the Dark (DID), in which C57BL/6J mice self-administer ethanol to a blood ethanol concentration (BEC) above 1 mg/ml. The test consists of replacing the water with 20

Garland Jr., Theodore

162

Fundamental Ca2 Signaling Mechanisms in Mouse Dendritic  

E-Print Network [OSTI]

Fundamental Ca2 Signaling Mechanisms in Mouse Dendritic Cells: CRAC Is the Major Ca2 Entry Pathway, Meyer B. Jackson, David E. Clapham,* and Gerard P. Ahern2 Although Ca2 -signaling processes are thought to underlie many dendritic cell (DC) functions, the Ca2 entry pathways are unknown. Therefore, we investigated

Clapham, David E.

163

Structure and Emergence of Specific Olfactory Glomeruli in the Mouse  

E-Print Network [OSTI]

in the olfactory bulb. Connecting 1000 populations of OSNs to the 1800 glomeruli of the mouse bulb poses fluorescent protein (GFP) or a fusion of tau with GFP. We visualized OSNs and their axons in whole mounts-expressing OSNs occupies a large surface area of the bulb and coalesces abruptly into a proto- glomerulus

164

Biophysical Journal Volume 68 May 1995 1787-1795 Molecular Dynamics in Mouse Atrial Tumor Sarcoplasmic Reticulum  

E-Print Network [OSTI]

-mail: ddt@ddt.biochem.umn.edu. Abbreviations used: SR, sarcoplasmic reticulum; MVSR, mouse ventricular SR

Thomas, David D.

165

Metformin prevents methylglyoxal-induced apoptosis of mouse Schwann cells  

SciTech Connect (OSTI)

Methylglyoxal (MG) is involved in the pathogenesis of diabetic complications via the formation of advanced glycation end products (AGEs) and reactive oxygen species (ROS). To clarify whether the antidiabetic drug metformin prevents Schwann cell damage induced by MG, we cultured mouse Schwann cells in the presence of MG and metformin. Cell apoptosis was evaluated using Hoechst 33342 nuclear staining, caspase-3 activity, and c-Jun-N-terminal kinase (JNK) phosphorylation. Intracellular ROS formation was determined by flow cytometry, and AMP-activated kinase (AMPK) phosphorylation was also examined. MG treatment resulted in blunted cell proliferation, an increase in the number of apoptotic cells, and the activation of caspase-3 and JNK along with enhanced intracellular ROS formation. All of these changes were significantly inhibited by metformin. No significant activation of AMPK by MG or metformin was observed. Taken together, metformin likely prevents MG-induced apoptotic signals in mouse Schwann cells by inhibiting the formation of AGEs and ROS.

Ota, Kimiko [Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya (Japan); Nakamura, Jiro [Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya (Japan); Li, Weiguo [Department of Cellular Biology and Anatomy, School Medical College of Georgia, Augusta, GA (United States); Kozakae, Mika [Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya (Japan); Watarai, Atsuko [Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya (Japan); Nakamura, Nobuhisa [Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya (Japan); Yasuda, Yutaka [Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya (Japan); Nakashima, Eirtaro [Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya (Japan); Naruse, Keiko [Department of Internal Medicine, School of Denistry, Aichi Gakuin University, Nagoya (Japan); Watabe, Kazuhiko [Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo (Japan); Kato, Koichi [Division of Endocrinology, Metabolism and Diabetology, Department of Internal Medicine, Aichi Medical University, Aichi (Japan); Oiso, Yutaka [Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya (Japan); Hamada, Yoji [Department of Metabolic Medicine, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550 (Japan)]. E-mail: yhama@med.nagoya-u.ac.jp

2007-05-25T23:59:59.000Z

166

KIRKWOOD MEADOWS PUBLIC UTILITY DISTRICT AGENDA REPORT  

E-Print Network [OSTI]

energy resources Enforcement Plan and Procurement Plan governing the procurement of a minimum quantity by the KMPUD pursuant to PUC § 399.30 Energy Commission: The State Energy Resources Conservation Discussion and Possible Action Approval of Resolution to Adopt the Renewable Portfolio Standard Enforcement

167

Cardwell Hills, Lupine Meadows, Bald Hill and  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed New Substation Sites Proposed RouteNanotube TemplatedStorage Medium toModulatesa

168

An Anisotropic Fluid-Solid Model of the Mouse Heart  

SciTech Connect (OSTI)

A critical challenge in biomechanical simulations is the spatial discretization of complex fluid-solid geometries created from imaging. This is especially important when dealing with Lagrangian interfaces, as there must be at a minimum both geometric and topological compatibility between fluid and solid phases, with exact matching of the interfacial nodes being highly desirable. We have developed a solution to this problem and applied the approach to the creation of a 3D fluidsolid mesh of the mouse heart. First, a 50 micron isotropic MRI dataset of a perfusion-fixed mouse heart was segmented into blood, tissue, and background using a customized multimaterial connected fuzzy thresholding algorithm. Then, a multimaterial marching cubes algorithm was applied to produce two compatible isosurfaces, one for the blood-tissue boundary and one for the tissue-background boundary. A multimaterial smoothing algorithm that rigorously conserves volume for each phase simultaneously smoothed the isosurfaces. Next we applied novel automated meshing algorithms to generate anisotropic hybrid meshes with the number of layers and the desired element anisotropy for each material as the only input parameters. As the meshes are scale-invariant within a material and include boundary layer prisms, fluid-structure interaction computations would have a relative error equilibrated over the entire mesh. The resulting model is highly detailed mesh representation of the mouse heart, including features such as chordae and coronary vasculature, that is also maximally efficient to produce the best simulation results for the computational resources available

Carson, James P.; Kuprat, Andrew P.; Jiao, Xiangmin; del Pin, Facundo; Einstein, Daniel R.

2010-01-01T23:59:59.000Z

169

E-Print Network 3.0 - allergy mouse model Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

CBMC proliferation... -cockroach, anti-mouse, and anti-dust mite IgE levels, wheeze, cough, eczema and asthma. Results: ... Source: Columbia University, Department of...

170

E-Print Network 3.0 - a140v mouse model Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Version 6. Official copy "Mouse" in Berkshire Encyclopedia of Human-Computer Interaction, W.S. Bainbridge (ed). 2004 by Berkshire Publishing Group. http:www.berkshirepublishing.c...

171

E-Print Network 3.0 - adult mouse tissues Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Shanghai Institute of Biological Sciences Collection: Biology and Medicine 25 A gene atlas of the mouse and human protein-encoding transcriptomes Summary: information on the...

172

E-Print Network 3.0 - adult mouse pancreas Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

mouse. Since there are human... expressed in the adult pancreas (data not ... Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo...

173

E-Print Network 3.0 - aging mouse brain Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Vol. 28, No. 19 OPTICS LETTERS 1739 Three-dimensional laser-induced photoacoustic tomography Summary: -induced photoacoustic tomography of mouse brain with the skin and skull...

174

Diarrhea as a cause of mortality in a mouse model of infectious colitis  

E-Print Network [OSTI]

Background: Comparative characterization of genome-wide transcriptional changes during infection can help elucidate the mechanisms underlying host susceptibility. In this study, transcriptional profiling of the mouse colon ...

Borenshtein, Diana

175

Optical properties of the mouse eye Ying Geng,1,2,*  

E-Print Network [OSTI]

Optical properties of the mouse eye Ying Geng,1,2,* Lee Anne Schery,1 Robin Sharma,1,2 Alfredo, University of Rochester, Rochester, NY, 14627, USA 2 The Institute of Optics, University of Rochester indicate that the optical quality of the mouse eye assessed by measurement of its aberrations is remarkably

176

Semi-Automated Reconstruction of Vascular Networks in Knife-Edge Scanning Microscope Mouse Brain Data  

E-Print Network [OSTI]

The KnifeEdge Scanning Microscope (KESM) enables imaging of an entire mouse brain at sub-micrometer resolution. The data from KESM can be used in the reconstruction of neuronal and vascular structures in the mouse brain. Tracing the vascular network...

Dileepkumar, Ananth

2014-08-14T23:59:59.000Z

177

Wild mouse open field behavior is embedded within the multidimensional data space spanned by laboratory  

E-Print Network [OSTI]

Wild mouse open field behavior is embedded within the multidimensional data space spanned- ius), while studies of wild-mouse behavior are relatively rare. An interesting question is the relationship between the phenotypes of M. laboratorius and the phenotypes of their wild ancestors

Golani, Ilan

178

Development of a Three-Dimensional Ball Rotation Sensing System using Optical Mouse Sensors  

E-Print Network [OSTI]

to the case of a ball wheel. The system measures surface speed by using two or more optical mouse sensorsDevelopment of a Three-Dimensional Ball Rotation Sensing System using Optical Mouse Sensors Masaaki Kumagai and Ralph L. Hollis Abstract-- Robots using ball(s) as spherical wheels have the advantage

179

Janus Experiments: Data from Mouse Irradiation Experiments 1972 - 1989  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

The Janus Experiments, carried out at Argonne National Laboratory from 1972 to 1989 and supported by grants from the US Department of Energy, investigated the effects of neutron and gamma radiation on mouse tissues primarily from B6CF1 mice. 49,000 mice were irradiated: Death records were recorded for 42,000 mice; gross pathologies were recorded for 39,000 mice; and paraffin embedded tissues were preserved for most mice. Mouse record details type and source of radiation [gamma, neutrons]; dose and dose rate [including life span irradiation]; type and presence/absence of radioprotector treatment; tissue/animal morphology and pathology. Protracted low dose rate treatments, short term higher dose rate treatments, variable dose rates with a same total dose, etc. in some cases in conjunction with radioprotectors, were administered. Normal tissues, tumors, metastases were preserved. Standard tissues saved were : lung, liver, spleen, kidney, heart, any with gross lesions (including mammary glands, Harderian gland with eye, adrenal gland, gut, ovaries or testes, brain and pituitary, bone). Data are searchable and specimens can be obtained by request.

180

Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice  

E-Print Network [OSTI]

al. ( 2007) Treatment of sickle cell anemia mouse model withan animal model of sickle cell anemia [36], or engraftment

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

A Systematic Analysis of a Deep Mouse Epididymal Sperm Proteome  

SciTech Connect (OSTI)

Spermatozoa are highly specialized cells that, when mature, are capable of navigating the female reproductive tract and fertilizing an oocyte. The sperm cell is thought to be largely quiescent in terms of transcriptional and translational activity. As a result, once it has left the male reproductive tract, the sperm cell is essentially operating with a static population of proteins. It is therefore theoretically possible to understand the protein networks contained in a sperm cell and to deduce its cellular function capabilities. To this end we have performed a proteomic analysis of mouse sperm isolated from the cauda epididymis and have confidently identified 2,850 proteins, which is the most comprehensive sperm proteome for any species reported to date. These proteins comprise many complete cellular pathways, including those for energy production via glycolysis, ?-oxidation and oxidative phosphorylation, protein folding and transport, and cell signaling systems. This proteome should prove a useful tool for assembly and testing of protein networks important for sperm function.

Chauvin, Theodore; Xie, Fang; Liu, Tao; Nicora, Carrie D.; Yang, Feng; Camp, David G.; Smith, Richard D.; Roberts, Kenneth P.

2012-12-21T23:59:59.000Z

182

Artificial leaf jumps developmental hurdle  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series to someone byDear Friend,Arthur J. Nozik - ResearchCenter Objective The

183

Curated Databases in the Life Sciences: The Edinburgh Mouse Atlas Project   

E-Print Network [OSTI]

This case study scopes and assesses the data curation aspects of the Edinburgh Mouse Atlas Project (EMAP), a programme funded by the Medical Research Council (MRC). The principal goal for EMAP is to develop an expression ...

Fairley, Elizabeth; Higgins, Sarah; Whyte, Angus

2009-06-29T23:59:59.000Z

184

Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase  

E-Print Network [OSTI]

The development of animal models of lung cancer is critical to our understanding and treatment of the human disease. Conditional mouse models provide new opportunities for testing novel chemopreventatives, therapeutics and ...

DuPage, Michel

185

E-Print Network 3.0 - adult mouse cord Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

comparison with spinal cord described later in Fig. 8B). In addition to mouse brains... bulb, a small but significant amount of MAb 15G8 binding persisted even in the adult...

186

E-Print Network 3.0 - adult mouse heart Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

heart Search Powered by Explorit Topic List Advanced Search Sample search results for: adult mouse heart Page: << < 1 2 3 4 5 > >> 1 Seminars in Cell & Developmental Biology 18...

187

Effects of Alcohol on the Regulation of Imprinted Genes in Mouse Stem Cells  

E-Print Network [OSTI]

ABSTRACT Effects of Alcohol on the Regulation of Imprinted Genes in Mouse Stem Cells. (December 2013) Alyssa Crocker Department of Animal Science Texas A&M University Research Advisor: Dr. Michael Golding Department of Veterinary Physiology...

Crocker, Alyssa

2013-02-04T23:59:59.000Z

188

Biophysical Probes of Iron Metabolism in Yeast Cells, Mitochondria, and Mouse Brains  

E-Print Network [OSTI]

resonance, electronic absorption spectroscopy, and inductively coupled plasma mass spectrometry. This integrated biophysical approach was applied to yeast cells, isolated yeast mitochondria, and mouse brains. We determined the concentration of Fe...

Holmes-Hampton, Gregory

2012-10-19T23:59:59.000Z

189

E-Print Network 3.0 - ameliorates mouse liver Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Diverse Roles of Invariant Natural Killer T Cells in Liver Injury and Fibrosis Induced by Carbon Tetrachloride Summary: are abundant in iNKT cells.13-17 For example, mouse liver...

190

E-Print Network 3.0 - aged mouse ovaries Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ovaries Search Powered by Explorit Topic List Advanced Search Sample search results for: aged mouse ovaries Page: << < 1 2 3 4 5 > >> 1 Journal of Reproduction and Fertility (1994)...

191

June 2004 283Notes DISTRIBUTION OF THE WHITE-ANKLED MOUSE  

E-Print Network [OSTI]

Nacional de las Cavernas de Carlsbad y localidades adyacentes en el extremo sureste de Nuevo Me). Much of our knowledge about the biology of this mouse in New Mexico comes from Carlsbad Caverns

192

A Novel Sensitive Method of Detecting Mnemonic Decline in Mouse Model of Alzheimer's Disease  

E-Print Network [OSTI]

of the requirements for the designation as UNDERGRADUATE RESEARCH SCHOLAR A Junior Scholars Thesis by REBECCA KAYE SIMMONS A NOVEL SENSITIVE METHOD OF DETECTING MNEMONIC DECLINE IN MOUSE MODEL OF ALZHEIMER?S DISEASE Approved by: Research... as UNDERGRADUATE RESEARCH SCHOLAR A Junior Scholars Thesis by REBECCA KAYE SIMMONS iii ABSTRACT A Novel Sensitive Method of Detecting Mnemonic Decline in Mouse Models of Alzheimer?s Disease. (April 2009) Rebecca Kaye Simmons Department of Psychology...

Simmons, Rebecca

2011-01-11T23:59:59.000Z

193

The Effects of Alcohol on the Regulation of Imprinted Genes in Mouse Embryonic Stem Cells  

E-Print Network [OSTI]

THE EFFECTS OF ALCOHOL ON THE REGULATION OF IMPRINTED GENES IN MOUSE EMBRYONIC STEM CELLS An Undergraduate Research Scholars Thesis by ELIZABETH MARY VILLANUEVA Submitted to Honors and Undergraduate Research Texas A... ................................................................................................... 25 2 ABSTRACT The Effects of Alcohol on the Regulation of Imprinted Genes in Mouse Embryonic Stem Cells. (May 2013) Elizabeth Mary Villanueva Department of Interdisciplinary Studies Texas A&M University Research Advisor: Dr...

Villanueva, Elizabeth Mary

2013-02-04T23:59:59.000Z

194

TLD assessment of mouse dosimetry during microCT imaging  

SciTech Connect (OSTI)

Advances in laboratory animal imaging have provided new resources for noninvasive biomedical research. Among these technologies is microcomputed tomography (microCT) which is widely used to obtain high resolution anatomic images of small animals. Because microCT utilizes ionizing radiation for image formation, radiation exposure during imaging is a concern. The objective of this study was to quantify the radiation dose delivered during a standard microCT scan. Radiation dose was measured using thermoluminescent dosimeters (TLDs), which were irradiated employing an 80 kVp x-ray source, with 0.5 mm Al filtration and a total of 54 mA s for a full 360 deg rotation of the unit. The TLD data were validated using a 3.2 cm{sup 3} CT ion chamber probe. TLD results showed a single microCT scan air kerma of 78.0{+-}5.0 mGy when using a poly(methylmethacrylate) (PMMA) anesthesia support module and an air kerma of 92.0{+-}6.0 mGy without the use of the anesthesia module. The validation CT ion chamber study provided a measured radiation air kerma of 81.0{+-}4.0 mGy and 97.0{+-}5.0 mGy with and without the PMMA anesthesia module, respectively. Internal TLD analysis demonstrated an average mouse organ radiation absorbed dose of 76.0{+-}5.0 mGy. The author's results have defined x-ray exposure for a routine microCT study which must be taken into consideration when performing serial molecular imaging studies involving the microCT imaging modality.

Figueroa, Said Daibes; Winkelmann, Christopher T.; Miller, William H.; Volkert, Wynn A.; Hoffman, Timothy J. [Harry S. Truman Memorial VA Hospital, Columbia, Missouri 65201 (United States) and Department of Radiology, University of Missouri, Columbia, Missouri 65201 (United States); Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri 65201 (United States); Nuclear Science and Engineering Institute, University of Missouri, Columbia, Missouri 65201 (United States); Department of Radiology, University of Missouri, Columbia, Missouri 65201 (United States); Harry S. Truman Memorial VA Hospital, Columbia, Missouri 65201 (United States) and Departments of Internal Medicine, Chemistry, and the Nuclear Science and Engineering Institute, University of Missouri, Columbia, Missouri 65201 (United States)

2008-09-15T23:59:59.000Z

195

Activation of farnesoid X receptor induces RECK expression in mouse liver  

SciTech Connect (OSTI)

Highlights: •RECK is a novel transcriptional target gene of FXR in mouse liver. •The FXR response element is located within the intron 1 of RECK gene. •FXR agonist reverses the down-regulation of RECK in the liver in mouse NASH model. -- Abstract: Farnesoid X receptor (FXR) belongs to the ligand-activated nuclear receptor superfamily, and functions as a transcription factor regulating the transcription of numerous genes involved in bile acid homeostasis, lipoprotein and glucose metabolism. In the present study, we identified RECK, a membrane-anchored inhibitor of matrix metalloproteinases, as a novel target gene of FXR in mouse liver. We found that FXR agonist substantially augmented hepatic RECK mRNA and protein expression in vivo and in vitro. FXR regulated the transcription of RECK through directly binding to FXR response element located within intron 1 of the mouse RECK gene. Moreover, FXR agonist reversed the down-regulation of RECK in the livers from mice fed a methionine and choline deficient diet. In summary, our data suggest that RECK is a novel transcriptional target of FXR in mouse liver, and provide clues to better understanding the function of FXR in liver.

Peng, Xiaomin [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China)] [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China); Wu, Weibin [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China) [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China); Institutes of Biomedical Sciences, Fudan University, Shanghai 200032 (China); Zhu, Bo; Sun, Zhichao; Ji, Lingling; Ruan, Yuanyuan [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China)] [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China); Zhou, Meiling, E-mail: meilingzhou2012@gmail.com [Department of Radiology, Zhongshan Hospital of Fudan University and Shanghai Institute of Medical Imaging, Shanghai 200032 (China)] [Department of Radiology, Zhongshan Hospital of Fudan University and Shanghai Institute of Medical Imaging, Shanghai 200032 (China); Zhou, Lei, E-mail: yhchloech@gmail.com [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China)] [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China); Gu, Jianxin [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China) [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China); Institutes of Biomedical Sciences, Fudan University, Shanghai 200032 (China)

2014-01-03T23:59:59.000Z

196

Ultrastructural study of Rift Valley fever virus in the mouse model  

SciTech Connect (OSTI)

Detailed ultrastructural studies of Rift Valley fever virus (RVFV) in the mouse model are needed to develop and characterize a small animal model of RVF for the evaluation of potential vaccines and therapeutics. In this study, the ultrastructural features of RVFV infection in the mouse model were analyzed. The main changes in the liver included the presence of viral particles in hepatocytes and hepatic stem cells accompanied by hepatocyte apoptosis. However, viral particles were observed rarely in the liver; in contrast, particles were extremely abundant in the CNS. Despite extensive lymphocytolysis, direct evidence of viral replication was not observed in the lymphoid tissue. These results correlate with the acute-onset hepatitis and delayed-onset encephalitis that are dominant features of severe human RVF, but suggest that host immune-mediated mechanisms contribute significantly to pathology. The results of this study expand our knowledge of RVFV-host interactions and further characterize the mouse model of RVF.

Reed, Christopher; Steele, Keith E.; Honko, Anna; Shamblin, Joshua; Hensley, Lisa E. [United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, MD (United States)] [United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, MD (United States); Smith, Darci R., E-mail: darci.smith1@us.army.mil [United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, MD (United States)

2012-09-15T23:59:59.000Z

197

Laser-Assisted In Vitro Fertilization Facilitates Fertilization of Vitrified-Warmed C57BL/6 Mouse Oocytes with Fresh and Frozen-Thawed Spermatozoa, Producing Live Pups  

E-Print Network [OSTI]

The utility of cryopreserved mouse gametes for reproduction of transgenic mice depends on development of assisted reproductive technologies, including vitrification of unfertilized mouse oocytes. Due to hardening of the ...

Woods, Stephanie E.

198

Inherited effects from mouse immature oocytes following low-dose irradiation  

SciTech Connect (OSTI)

Immature oocytes represent the genetic pool in female mice as well as in women and therefore are principal cells of concern for genetic studies. Previous studies have demonstrated that genetic effects in female mice can be masked by the hypersensitive plasma membrane lethality target of immature oocytes. Studies have also shown that genetic effects can be detected when the plasma mambrane is sufficiently spared. Here, new data obtained using the mouse preimplantation embryo chimera assay are presented and discussed in light of previous findings for irradiated mouse oocytes.

Straume, T. [Lawrence Livermore National Lab., CA (United States); Khan, R.; Raabe, O.G.; Walsh, K.J.; Wiley, L.M. [California Univ., Davis, CA (United States). Institute of Toxicology and Environmental Health

1992-07-01T23:59:59.000Z

199

Presentation: Lithium ameliorates behavioral deficits in mouse model of fragile X syndrome-550.12  

E-Print Network [OSTI]

Presentation: Lithium ameliorates behavioral deficits in mouse model of fragile X syndrome-550 deficits. Lithium is used clinically to treat bipolar disorder, and it has been used to treat mood dysregulation in individuals with FrX. Lithium has also been shown to reverse learning deficits and improve

Smith, Carolyn Beebe

200

Heart valve cardiomyocytes of mouse embryos express the serotonin transporter SERT  

SciTech Connect (OSTI)

Multiple evidence demonstrate a role for serotonin and its transporter SERT in heart valve development and disease. By utilizing a Cre/loxP system driven by SERT gene expression, we recently demonstrated a regionally restricted distribution of SERT-expressing cells in developing mouse heart. In order to characterize the cell types exhibiting SERT expression within the mouse heart valves at early developmental stages, in this study we performed immunohistochemistry for Islet1 (Isl1) and connexin-43 (Cx-43) on heart sections from SERT{sup Cre/+};ROSA26R embryos previously stained with X-gal. We observed the co-localization of LacZ staining with Isl1 labelling in the outflow tract, the right ventricle and the conal region of E11.5 mouse heart. Cx-43 labelled cells co-localized with LacZ stained cells in the forming atrioventricular valves. These results demonstrate the cardiomyocyte phenotype of SERT-expressing cells in heart valves of the developing mouse heart, thus suggesting an active role of SERT in early heart valve development.

Pavone, Luigi Michele [Department of Biological Structures, Functions and Technologies, University of Naples Federico II, Via F. Delpino 1, 80137 Naples (Italy); Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II, Naples (Italy)], E-mail: pavone@dbbm.unina.it; Spina, Anna; Lo Muto, Roberta; Santoro, Dionea [Department of Biological Structures, Functions and Technologies, University of Naples Federico II, Via F. Delpino 1, 80137 Naples (Italy); Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II, Naples (Italy); Mastellone, Vincenzo [Department of Experimental Medicine 'G. Salvatore', University of Magna Graecia, Catanzaro (Italy); Avallone, Luigi [Department of Biological Structures, Functions and Technologies, University of Naples Federico II, Via F. Delpino 1, 80137 Naples (Italy)

2008-12-12T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Polyclonality of familial murine adenomas: Analyses of mouse chimeras with low tumor multiplicity  

E-Print Network [OSTI]

Polyclonality of familial murine adenomas: Analyses of mouse chimeras with low tumor multiplicity) and homozygous for the tumor resistance allele of the Mom1 locus were established. These chimeras also display of patches in chimeras or mosaics heterotypic for a clonal lineage marker. The ability to detect

Dove, William

202

In vivo fluorescent imaging of the mouse retina using adaptive optics  

E-Print Network [OSTI]

in the retina of a mouse, using a microelectromechanical system membrane mirror and a Shack­Hartmann wave- front is a powerful tool that allows fol- lowing a single animal over time. A major problem with implementing (Dual Calypso laser, Co- bolt AB, Stockholm, Sweden). An entrance pupil is formed at the source

203

Helicobacter pylori tissue tropism: mouse-colonizing strains can target different  

E-Print Network [OSTI]

Helicobacter pylori tissue tropism: mouse-colonizing strains can target different gastric niches-adapted Helicobacter pylori strain SS1 had supported an idea that infections by this pathogen start in the gastric diversity and genome evolution. INTRODUCTION Helicobacter pylori chronically infects the gastric mucosa

Cheverud, James M.

204

General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex  

E-Print Network [OSTI]

General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex. However, the direct effect of general anesthesia on astrocyte signaling in awake animals has not pre, anesthesia affected calcium transients in both processes and soma and depressed spontaneous signals, as well

Newman, Eric A.

205

Evolutionary Conservation of Expression Profiles Between Human and Mouse Orthologous Genes  

E-Print Network [OSTI]

­array-based observations from many individual genes and imply the uselessness of mouse models for studying human genes­profiling technologies became available (Cavalieri, Townsend, and Hartl 2000; Enard et al. 2002; Oleksiak, Churchill all the technologies for producing transcriptome data, the DNA (oligonucleotide or cDNA) microarray

Zhang, Jianzhi

206

Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain  

E-Print Network [OSTI]

Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain Hans entire neuronal networks for analysis in the intact brain has been impossible up to now. Techniques like in micro computer tomogrpahy and mMRI does not resolve individual cells1,2. On a microscopic scale

Cai, Long

207

SkyMouse: A smart interface for astronomical on-line resources and services  

E-Print Network [OSTI]

With the development of network and the World Wide Web (WWW), the Internet has been growing and changing dramatically. More and more on-line database systems and different kinds of services are available for astronomy research. How to help users find their way through the jungle of information services becomes an important challenge. Although astronomers have been aware of the importance of interoperability and introduced the concept of Virtual Observatory as a uniform environment for future astronomical on-line resources and services, transparent access to heterogeneous on-line information is still difficult. SkyMouse is a lightweight interface for distributed astronomical on-line resources and services, which is designed and developed by us, i.e., Chinese Virtual Observatory Project. Taking advantage of screen word-capturing technology, different kinds of information systems can be queried through simple mouse actions, and results are returned in a uniform web page. SkyMouse is an easy to use application, aiming to show basic information or to create a comprehensive overview of a specific astronomical object. In this paper current status of on-line resources and services access is reviewed; system architecture, features and functions of SkyMouse are described; challenges for intelligent interface for on-line astronomical resources and services are discussed.

Chen-Zhou CUI; Hua-Ping SUN; Yong-Heng ZHAO; Yu LUO; Da-Zhi QI

2007-11-27T23:59:59.000Z

208

Circ Res . Author manuscript Nanobodies targeting mouse/human VCAM1 for the nuclear imaging of  

E-Print Network [OSTI]

Wernery 7 , Vicky Caveliers 3 8 , Serge Muyldermans 4 5 , Tony Lahoutte 3 8 , Daniel Fagret 1 2 on mouse and human recombinant VCAM1 proteins and endothelial cells and inin vitro in vivo ApoE-deficient (ApoE ) mice. A nontargeting control nanobody was used in all experiments to demonstrate specificity

Paris-Sud XI, Université de

209

Caspase Activation in Hair Cells of the Mouse Utricle Exposed to Neomycin  

E-Print Network [OSTI]

Caspase Activation in Hair Cells of the Mouse Utricle Exposed to Neomycin Lisa L. Cunningham, Alan exposure results in the apoptotic destruction of auditory and vestibular hair cells. This ototoxic hair, immunohistochemistry, and specific caspase inhibitors to determine which caspases are activated in the hair cells

Rubel, Edwin

210

12/4/09 10:18 AMComputer Power User Article -X-ray Vision: Built-In Repair Centers Page 1 of 1http://www.computerpoweruser.com/editorial/article.asp?article=art...B2C52BEC685E6F18&searchtype=0&WordList=JEFFREY+MOORE&bJumpTo=True  

E-Print Network [OSTI]

://www.computerpoweruser.com/editorial/article.asp?article=art...B2C52BEC685E6F18&searchtype=0&WordList=JEFFREY+MOORE&bJumpTo=True Home | Forums | Article Search

Braun, Paul

211

Flow cytometry quantitation of dopamine receptor D2 loss as a sensitive measure of Huntington's Disease progression in mouse neurons  

E-Print Network [OSTI]

Mouse models of Huntington's Disease (HD) are often used for testing potential therapeutic compounds. These experiments require substantial investments in time and resources, and have yet to produce any intervention that ...

Crook, Zachary R. (Zachary Ryan)

2013-01-01T23:59:59.000Z

212

Rapid Structural Remodeling of Thalamocortical Synapses Parallels Experience-Dependent Functional Plasticity in Mouse Primary Visual Cortex  

E-Print Network [OSTI]

Monocular lid closure (MC) causes a profound shift in the ocular dominance (OD) of neurons in primary visual cortex (V1). Anatomical studies in both cat and mouse V1 suggest that large-scale structural rearrangements of ...

Coleman, Jason E.

213

The PanK2 Genes of Mouse and Human Specify Proteins with DistinctSubcellular Locations  

SciTech Connect (OSTI)

Coenzyme A (CoA) biosynthesis is initiated by pantothenatekinase (PanK) and CoA levels are controlled through differentialexpression and feedback regulation of PanK isoforms. PanK2 is amitochondrial protein in humans, but comparative genomics revealed thatacquisition of a mitochondrial targeting signal was limited to primates.Human and mouse PanK2 possessed similar biochemical properties, withinhibition by acetylCoA and activation by palmitoylcarnitine. Mouse PanK2localized in the cytosol, and the expression of PanK2 was higher in humanbrain compared to mouse brain. Differences in expression and subcellularlocalization should be considered in developing a mouse model for humanPanK2 deficiency. (c) 2007 Federation of European Biochemical Societies.Published by Elsevier B.V.

Leonardi, Roberta; Zhang, Yong-Mei; Lydikis, Athanasios; Stevens,Robert D.; Ilkayeva, Olga R.; Wenner, Brett R.; Bain, James R.; Newgard,Christopher B.; Rock, Charles O.; Jackowski, Suzanne

2007-05-01T23:59:59.000Z

214

A filtered database search algorithm for endogenous serum protein carbonyl modifications in a mouse model of inflammation  

E-Print Network [OSTI]

During inflammation, the resulting oxidative stress can damage surrounding host tissue, forming protein-carbonyls. The SJL mouse is an experimental animal model used to assess in vivo toxicological responses to reactive ...

Slade, Peter G.

215

The Consensus Coding Sequence (Ccds) Project: Identifying a Common Protein-Coding Gene Set for the Human and Mouse Genomes  

E-Print Network [OSTI]

Effective use of the human and mouse genomes requires reliable identification of genes and their products. Although multiple public resources provide annotation, different methods are used that can result in similar but ...

Kellis, Manolis

216

FUNCTIONAL AND MECHANISTIC STUDY OF DOT1L IN MOUSE EMBRYONIC HEMATOPOIESIS  

E-Print Network [OSTI]

recognized that two distinct populations of red cells circulate in the blood stream of mouse embryos. The first population, the “primitive” red cells, are extremely large, nucleated red cells, which originate from the yolk sac2. Shortly after that, a second... to our increasing knowledge over time. For example, at first the primitive red cells are thought to be always nucleated and have the same characteristics with the nucleated nonmammalian red cells. Also originally, people believed that definitive...

Feng, Yi

2012-12-31T23:59:59.000Z

217

Effect of gamma-linolenic acid on mouse macrophage prostaglandin E1 synthesis and phospholipid metabolism  

E-Print Network [OSTI]

, in this study, the modulatory effect of dietary GLA on mouse peritoneal macrophage PGEI, PGE2 and PGI2 biosynthesis is presented. MATERIALS AND METHODS Materials All tissue culture media were purchased from Whitaker M. A. Bioproducts (Walkersville, MD... in the PGE2 RIA kit (Nuclear Magnetics, Cambridge, MA) was 100% and 50%, respectively, as determined by the manufacturer and confirmed by our preliminary test (Appendix II). Therefore, the apparent concentration of immunoreactive PGEI was multiplied by two...

Fan, Yang-Yi

1992-01-01T23:59:59.000Z

218

Radiation-Induced Alterations in Mouse Brain Development Characterized by Magnetic Resonance Imaging  

SciTech Connect (OSTI)

Purpose: The purpose of this study was to identify regions of altered development in the mouse brain after cranial irradiation using longitudinal magnetic resonance imaging (MRI). Methods and Materials: Female C57Bl/6 mice received a whole-brain radiation dose of 7 Gy at an infant-equivalent age of 2.5 weeks. MRI was performed before irradiation and at 3 time points following irradiation. Deformation-based morphometry was used to quantify volume and growth rate changes following irradiation. Results: Widespread developmental deficits were observed in both white and gray matter regions following irradiation. Most of the affected brain regions suffered an initial volume deficit followed by growth at a normal rate, remaining smaller in irradiated brains compared with controls at all time points examined. The one exception was the olfactory bulb, which in addition to an early volume deficit, grew at a slower rate thereafter, resulting in a progressive volume deficit relative to controls. Immunohistochemical assessment revealed demyelination in white matter and loss of neural progenitor cells in the subgranular zone of the dentate gyrus and subventricular zone. Conclusions: MRI can detect regional differences in neuroanatomy and brain growth after whole-brain irradiation in the developing mouse. Developmental deficits in neuroanatomy persist, or even progress, and may serve as useful markers of late effects in mouse models. The high-throughput evaluation of brain development enabled by these methods may allow testing of strategies to mitigate late effects after pediatric cranial irradiation.

Gazdzinski, Lisa M.; Cormier, Kyle [Mouse Imaging Centre, Hospital for Sick Children, Toronto (Canada)] [Mouse Imaging Centre, Hospital for Sick Children, Toronto (Canada); Lu, Fred G. [Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto (Canada)] [Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto (Canada); Lerch, Jason P. [Mouse Imaging Centre, Hospital for Sick Children, Toronto (Canada) [Mouse Imaging Centre, Hospital for Sick Children, Toronto (Canada); Department of Medical Biophysics, University of Toronto, Toronto (Canada); Wong, C. Shun [Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto (Canada) [Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto (Canada); Department of Medical Biophysics, University of Toronto, Toronto (Canada); Department of Radiation Oncology, University of Toronto, Toronto (Canada); Nieman, Brian J., E-mail: bjnieman@phenogenomics.ca [Mouse Imaging Centre, Hospital for Sick Children, Toronto (Canada); Department of Medical Biophysics, University of Toronto, Toronto (Canada)

2012-12-01T23:59:59.000Z

219

Microsoft Word - FarmPowerMistyMeadows_CX_2012.docx  

Broader source: Energy.gov (indexed) [DOE]

BPA would provide Farm Power with parts for installing a standard BPA JEMSTAR revenue meter, along with example design drawings. BPA would review and approve the drawings prior...

220

Polymictic pool behavior in a montane meadow, Sierra Nevada, CA  

E-Print Network [OSTI]

scale measurements, such as DTS or FLIR, and may help assessForward Looking Infrared ( FLIR) is often used in studiesLoheide and Gorelick, 2006). FLIR only captures the surface

Lucas, Ryan Geoffrey

2013-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Polymictic pool behavior in a montane meadow, Sierra Nevada, CA  

E-Print Network [OSTI]

LP-33 PLOTTED WITH NET SOLAR RADIATION AND AIR TEMPERATURES33 PLOTTED WITH NET SOLAR RADIATION AND AIR TEMPERATURE FORA-2 COMPARISON OF NET SOLAR RADIATION AS CALCULATED FROM THE

Lucas, Ryan Geoffrey

2013-01-01T23:59:59.000Z

222

Truckee Meadows Community College and Colorado School of Mines Win  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: AlternativeEnvironment,Institutes and1Telework TeleworkTime-BasedTopTribal

223

Case Study: Mobile Photovoltaic System at Bechler Meadows Ranger Station,  

Broader source: Energy.gov (indexed) [DOE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarly Career Scientists' ResearchTheMarketing,Energy-ChevronSeveral salesCarolyn L.in a

224

Case Study: Mobile Photovoltaic System at Bechler Meadows Ranger...  

Broader source: Energy.gov (indexed) [DOE]

remote outpost is not served by the electric utility grid and previously relied on a propane generator as the only source of power. 60516.pdf More Documents & Publications...

225

Sertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic hearts  

SciTech Connect (OSTI)

Highlights: •SERTAD1 interacts with SMAD1. •Sertad1 is expressed in mouse embryonic hearts. •SERTAD1 is localized in both cytoplasm and nucleus of cardiomyocytes. •SERTAD1 enhances expression of BMP target cardiogenic genes as a SMAD1 co-activator. -- Abstract: Despite considerable advances in surgical repairing procedures, congenital heart diseases (CHDs) remain the leading noninfectious cause of infant morbidity and mortality. Understanding the molecular/genetic mechanisms underlying normal cardiogenesis will provide essential information for the development of novel diagnostic and therapeutic strategies against CHDs. BMP signaling plays complex roles in multiple cardiogenic processes in mammals. SMAD1 is a canonical nuclear mediator of BMP signaling, the activity of which is critically regulated through its interaction partners. We screened a mouse embryonic heart yeast two-hybrid library using Smad1 as bait and identified SERTAD1 as a novel interaction partner of SMAD1. SERTAD1 contains multiple potential functional domains, including two partially overlapping transactivation domains at the C terminus. The SERTAD1-SMAD1 interaction in vitro and in mammalian cells was further confirmed through biochemical assays. The expression of Sertad1 in developing hearts was demonstrated using RT-PCR, western blotting and in situ hybridization analyses. We also showed that SERTAD1 was localized in both the cytoplasm and nucleus of immortalized cardiomyocytes and primary embryonic cardiomyocyte cultures. The overexpression of SERTAD1 in cardiomyocytes not only enhanced the activity of two BMP reporters in a dose-dependent manner but also increased the expression of several known BMP/SMAD regulatory targets. Therefore, these data suggest that SERTAD1 acts as a SMAD1 transcriptional co-activator to promote the expression of BMP target genes during mouse cardiogenesis.

Peng, Yin [Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294 (United States)] [Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294 (United States); Zhao, Shaomin [Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294 (United States) [Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294 (United States); School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069 (China); Song, Langying [Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294 (United States)] [Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294 (United States); Wang, Manyuan [School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069 (China)] [School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069 (China); Jiao, Kai, E-mail: kjiao@uab.edu [Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294 (United States)] [Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294 (United States)

2013-11-29T23:59:59.000Z

226

Proteome and Transcriptome Profiles of a Her2/Neu-driven Mouse Model of Breast Cancer  

SciTech Connect (OSTI)

In recent years, mouse models have proven to be invaluable in expanding our understanding of cancer biology. We have amassed a tremendous amount of proteomics and transcriptomics data profiling blood and tissues from a Her2-driven mouse model of breast cancer that closely recapitulates the pathology and natural history of human breast cancer. The purpose of this report is to make all of these data publicly available in raw and processed forms, as a resource to the community. Importantly, high quality biospecimens from this same mouse model are freely available through a sample repository that we established, so researchers can readily obtain samples to test biological hypotheses without the need of breeding animals and collecting biospecimens. Specifically, six proteomics and six transcriptomics datasets are available, with the former encompassing 841 liquid chromatography-tandem mass spectrometry (LC-MS/MS) experiments of both plasma and tissue samples, and the latter including 255 individual microarray analyses of five different tissue types (thymus, spleen, liver, blood cells, and breast ± laser capture microdissection). A total of 18,880 unique peptides were identified with a PeptideProphet error rate ?1%, with 3884 non-redundant protein groups identified in five plasma datasets, and 1659 non-redundant protein groups in a tissue dataset (4977 non-redundant protein groups in total). We anticipate that these data will be of use to the community for software tool development, investigations of analytical variation in MS/MS data, development of quality control tools (multiple technical replicates are provided for a subset of the data), empirical selection of proteotypic peptides for multiple reaction monitoring mass spectrometry, and for advancing our understanding of cancer biology.

Schoenherr, Regine M.; Kelly-Spratt, Karen S.; Lin, Chen Wei; Whiteaker, Jeffrey R.; Liu, Tao; Holzman, Ted; Coleman, Ilsa; Feng, Li-Chia; Lorentzen, Travis D.; Krasnoselsky, Alexei L.; Wang, Pei; Liu, Yan; Gurley, Kay E.; Amon, Lynn M.; Schepmoes, Athena A.; Moore, Ronald J.; Camp, David G.; Chodosh, Lewis A.; Smith, Richard D.; Nelson, Peter S.; McIntosh, Martin; Kemp, Christopher; Paulovich, Amanda G.

2011-04-01T23:59:59.000Z

227

Pointright: a system to redirect mouse and keyboard control among multiple machines  

DOE Patents [OSTI]

The present invention provides a software system, PointRight, that allows for smooth and effortless control of pointing and input devices among multiple displays. With PointRight, a single free-floating mouse and keyboard can be used to control multiple screens. When the cursor reaches the edge of a screen it seamlessly moves to the adjacent screen and keyboard control is simultaneously redirected to the appropriate machine. Laptops may also redirect their keyboard and pointing device, and multiple pointers are supported simultaneously. The system automatically reconfigures itself as displays go on, go off, or change the machine they display.

Johanson, Bradley E. (Palo Alto, CA); Winograd, Terry A. (Stanford, CA); Hutchins, Gregory M. (Mountain View, CA)

2008-09-30T23:59:59.000Z

228

Embryotoxic and histopathologic effects of aflatoxin B1 during early pregnancy in the mouse  

E-Print Network [OSTI]

During Early Pregnancy in the Mouse, (August 1990) Ying Jia-Hsu, M. D. , Capital Institute of Medicine Co-chairs of Advisory Committee: Dr. T, Rick Irvin Dr. John E. Martin The in vivo embryotoxicity of aflatoxin Bl (AFB1) on mice..., and with histopathologic changes that occur as a result of exposure to AFB1 at a single maximum tolerate dose on gestation day 2 or gestation day 4 were characterized, and the correlation of the embryotoxic and histopathologic effects of AFB1 on pregnant mice...

Jia-Hsu, Ying

2012-06-07T23:59:59.000Z

229

The genetic control of avascular area in mouse oxygen-induced retinopathy  

E-Print Network [OSTI]

data. Due to inconsistencies in the genotyping results, an albino female mouse from the low avascular area group was excluded from subsequent analysis. The genotype of the tyrosinase locus of the mice not selected for genotyping was inferred from coat... color. In this cross, albinism was conferred by homozygosity for the BALB/c allele of tyrosinase. The genotype of albino mice at the tyrosinase locus was encoded as AB/cAB/c. For all non- albino mice, a code indicating “not-AB/cAB/c” was used. QTL...

O'Bryhim, Bliss; Radel, Jeff; Macdonald, Stuart J.; Symons, R. C. Andrew

2012-02-08T23:59:59.000Z

230

Comparative promoter activities of three endogenous copies of mouse mammary tumor virus  

E-Print Network [OSTI]

to 12 CC ~ o c 0 tu x MMTV M13 pLC1 ?(, a~ CAT pBR322 0/ I SV40 Figure 5. Diagram of pLC1. The plasmid pLC1 (Toohey et al. , 1986) contains an Intact LTR obtained from the C3H provirus as a Pst I restriction fragment. The plasmid also...COMPARATIVE PROMOTER ACTIVITIES OF THREE ENDOGENOUS COPIES OF MOUSE MAMMARY TUMOR VIRUS A Thesis by LAURA REID VILANDER Submitted to the Graduate College of Texas A&M University in partial fulfilment of the requirements for the degree...

Vilander, Laura Reid

1987-01-01T23:59:59.000Z

231

Simulating Temperature Jumps for Protein Folding Studies.  

E-Print Network [OSTI]

??Protein folding is described as a dynamic process of an ensemble of molecules reaching well-defined three dimensional structures to achieve biological activity from linear amino… (more)

Kim, Seonah

2007-01-01T23:59:59.000Z

232

Jumping-Droplet Electrostatic Energy Harvesting  

E-Print Network [OSTI]

Micro- and nanoscale wetting phenomena has been an active area of research due to its potential for improving engineered system performance involving phase change. With the recent advancements in micro/nanofabrication ...

Miljkovic, Nenad

2014-06-19T23:59:59.000Z

233

Dynamics of Snapping Beams and Jumping Poppers  

E-Print Network [OSTI]

We consider the dynamic snapping instability of elastic beams and shells. Using the Kirchhoff rod and F\\"{o}ppl-von K\\'{a}rm\\'{a}n plate equations, we study the stability, deformation modes, and snap-through dynamics of an elastic arch with clamped boundaries and subject to a concentrated load. For parameters typical of everyday and technological applications of snapping, we show that the stretchability of the arch plays a critical role in determining not only the post-buckling mode of deformation but also the timescale of snapping and the frequency of the arch's vibrations about its final equilibrium state. We show that the growth rate of the snap-through instability and its subsequent ringing frequency can both be interpreted physically as the result of a sound wave in the material propagating over a distance comparable to the length of the arch. Finally, we extend our analysis of the ringing frequency of indented arches to understand the `pop' heard when everted shell structures snap-through to their stable state. Remarkably, we find that not only are the scaling laws for the ringing frequencies in these two scenarios identical but also the respective prefactors are numerically close; this allows us to develop a master curve for the frequency of ringing in snapping beams and shells.

Anupam Pandey; Derek E. Moulton; Dominic Vella; Douglas P. Holmes

2014-02-20T23:59:59.000Z

234

Effect of nitroimidazoles on glucose utilization and lactate accumulation in mouse brain  

SciTech Connect (OSTI)

The radiation sensitizers misonidazole (MISO) and desmethylmisonidazole (DMM) can produce central and peripheral neuropathy in patients and laboratory animals. Nitroimidazoles can also interfere with glycolysis in vitro under aerobic and anaerobic conditions. In the present work, the authors studied the effect of MISO or DMM on lactate production and glucose utilization in mouse brain. It is observed that these compounds result in a 25% inhibition of lactate production in brain slices relative to the control at a 10 mM level. Additionally, MISO (1.0 mg/g/day) or DMM (1.4 mg/g/day) were administered daily (oral) for 1, 4, 7, or 14 days to examine the effect of these two drugs on the regional glucose utilization in C3Hf mouse brain. Five microcuries of 2-deoxy(/sup 14/C)glucose was given following the last drug dose and autoradiographs of serial brain sections were made and analyzed by a densitometer. Following a single dose of either MISO or DMM, no significant differences in glucose uptake were observed when compared with controls. However, following 4, 7, and 14 doses the rate of glucose utilization was significantly reduced in the intoxicated animals. Larger reductions were measured in specific regions including the posterior colliculus, cochlear nuclei, vestibular nuclei, and pons with increasing effects observed at later stages. These results share a degree of correspondence with the regional brain pathology produced by these nitroimidazoles.

Chao, C.F. (Roswell Park Memorial Inst., Buffalo, NY); Subjeck, J.R.; Brody, H.; Shen, J.; Johnson, R.J.R.

1984-01-01T23:59:59.000Z

235

Impact of Mouse Model on Pre-Clinical Dosimetry in Targeted Radionuclide Therapy Samir Boutaleb1,2  

E-Print Network [OSTI]

1/1 Impact of Mouse Model on Pre-Clinical Dosimetry in Targeted Radionuclide Therapy Samir Boutaleb animal dosimetry serves as an important link in establishing a relationship between absorbed dose are based on models aiming at representing the animals used during pre-clinical experiments. However

Boyer, Edmond

236

High concentrations of morphine sensitize and activate mouse dorsal root ganglia via TRPV1 and TRPA1 receptors  

E-Print Network [OSTI]

and sensitized the release evoked by heat or the TRPA1 agonist acrolein. Morphine activated HEK293t cells transfected with TRPV1 or TRPA1. Activation of C57BL/6 mouse dorsal root ganglion neurons in culture was investigated with calcium imaging. Morphine induced...

Forster, Alexander B; Reeh, Peter; Messlinger, Karl; Fischer, Michael J M

2009-04-16T23:59:59.000Z

237

Silencing of SPC2 Expression Using an Engineered Ribozyme in the Mouse TC-3 Endocrine Cell Line*  

E-Print Network [OSTI]

Silencing of SPC2 Expression Using an Engineered Ribozyme in the Mouse TC-3 Endocrine Cell Line the distinct roles of a member of this family (SPC2), gene silencing in cultured cells is an ideal approach to establish TC-3 stable cell lines expressing the chimeric tRNAVal - ribozyme transcript targeting SPC2 m

Perreault, Jean-Pierre

238

Slow oscillations of KATP conductance in mouse pancreatic islets provide support for electrical bursting driven by metabolic oscillations  

E-Print Network [OSTI]

of the ramp current-voltage curves, oscillated and was larger during the silent phase than during the activeSlow oscillations of KATP conductance in mouse pancreatic islets provide support for electrical bursting driven by metabolic oscillations Jianhua Ren,1 Arthur Sherman,2 Richard Bertram,3 Paulette B

Bertram, Richard

239

Whole Slide Image Analysis Quantification using Aperio Digital Imaging in a Mouse Lung Metastasis Ronne L. Surface2  

E-Print Network [OSTI]

Whole Slide Image Analysis Quantification using Aperio Digital Imaging in a Mouse Lung Metastasis, Indiana University School of Medicine Digital whole slide imaging is the technique of digitizing a microscope slide at the highest resolution to produce a "digital virtual microscope slide". This digital

Zhou, Yaoqi

240

3D segmentation of mouse organs from MR images using deformable simplex mesh models G. Hamarneh1  

E-Print Network [OSTI]

3D segmentation of mouse organs from MR images using deformable simplex mesh models G. Hamarneh1 , H. Delingette2 , M. Henkelman1 1 Hospital for Sick Children, Toronto, ON, Canada, 2 INRIA brains and kidneys from MR images. Algorithmic details and 3D segmentation results are presented

Hamarneh, Ghassan

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

``In-bone'' Utricle CulturesVA Simplified, Atraumatic Technique for In Situ Cultures of the Adult Mouse  

E-Print Network [OSTI]

effectively in stud- ies of hair cell regeneration and hair cell death, as well as various agents that protect and protection. Background: The current in vitro technique for studying hair cells of the mature mouse utricle to the protective drug tacrine resulted in sig- nificant protection against neomycin (p G 0.05, 3-way analysis

Rubel, Edwin

242

Mechanoelectrical Transduction and Adaptation in Hair Cells of the Mouse Utricle, a Low-Frequency Vestibular Organ  

E-Print Network [OSTI]

Mechanoelectrical Transduction and Adaptation in Hair Cells of the Mouse Utricle, a Low and Communicative Sciences, Baylor College of Medicine, Houston, Texas 77030 Hair cells of inner ear organs sensitive to frequencies above 10 Hz adapt to maintained hair bundle deflections at rates that reduce

Corey, David P.

243

PACAP Interactions in the Mouse Brain: Implications for Behavioral and Other Disorders  

SciTech Connect (OSTI)

As an activator of adenylate cyclase, the neuropeptide Pituitary Adenylate Cyclase Activating Peptide (PACAP) impacts levels of cyclic AMP, a key second messenger available in brain cells. PACAP is involved in certain adult behaviors. To elucidate PACAP interactions, a compendium of microarrays representing mRNA expression in the adult mouse whole brain was pooled from the Phenogen database for analysis. A regulatory network was computed based on mutual information between gene pairs using gene expression data across the compendium. Clusters among genes directly linked to PACAP, and probable interactions between corresponding proteins were computed. Database 'experts' affirmed some of the inferred relationships. The findings suggest ADCY7 is probably the adenylate cyclase isoform most relevant to PACAP's action. They also support intervening roles for kinases including GSK3B, PI 3-kinase, SGK3 and AMPK. Other high-confidence interactions are hypothesized for future testing. This new information has implications for certain behavioral and other disorders.

Acquaah-Mensah, George; Taylor, Ronald C.; Bhave, Sanjiv V.

2012-01-10T23:59:59.000Z

244

A simple, low-cost, data logging pendulum built from a computer mouse  

SciTech Connect (OSTI)

Lessons and homework problems involving a pendulum are often a big part of introductory physics classes and laboratory courses from high school to undergraduate levels. Although laboratory equipment for pendulum experiments is commercially available, it is often expensive and may not be affordable for teachers on fixed budgets, particularly in developing countries. We present a low-cost, easy-to-build rotary sensor pendulum using the existing hardware in a ball-type computer mouse. We demonstrate how this apparatus may be used to measure both the frequency and coefficient of damping of a simple physical pendulum. This easily constructed laboratory equipment makes it possible for all students to have hands-on experience with one of the most important simple physical systems.

Gintautas, Vadas [Los Alamos National Laboratory; Hubler, Alfred [UIUC

2009-01-01T23:59:59.000Z

245

Molecular mapping of the tubby (tub) mutation on mouse chromosome 7  

SciTech Connect (OSTI)

Using 180 F2 progeny of a C57BL6/J x CAST/Ei tub/+F1 intersubspecific intercross, a map of 28 molecular markers (including eight genes) on chromosome 7 surrounding the tub locus was generated. Using 33 obese F2 progeny, tub was localized approximately 50-52 cM distal to the centromere on mouse chromosome 7 in the interval defined proximally by hemoglobin beta (Hbb), D7Mit38, D7Mit217, D7Mit37, D7Mit96, and D7Mit33 and distally by D7Mit 98. Using 39 obese F2 progeny from a similar intersubspecific intercross, a telomeric boundary of the interval defining tub was defined by D7Mit53; the order centromere-Hbb/tub-D7Mit53/D7Mit328/D7Mit220-parathyroid hormone (Pth)-calcitonin (Calc)-zona pellucida 2 (2p2) was established. By combining the data from the two crosses, the most likely gene order on mouse chromosome 7 is centromere-Hbb-tub-Pth-Calc, thus making it likely that the human homolog of tub resides on 11p15, where the gene order HBB-PTH-CALC is conserved. Assignment of the human tubby homolog to 11p15 allows selection and development of polymorphic molecular markers that can be used to examine segregation of a human homolog of tubby in pedigrees segregating for obesity. The gene sulfonylurea receptor was eliminated as a candidate gene for tubby on the basis of its map position, approximately 3.1 {plus_minus} 3.1 cM centromeric of tyrosinase and approximately 14.9 {plus_minus} 4.8 cM centromeric of Hbb. 47 refs., 2 figs., 2 tabs.

Chung, W.K.; Goldberg-Berman, J.; Power-Kehoe, L.; Leibel, R.L. [Rockefeller Univ., New York, NY (United States)] [Rockefeller Univ., New York, NY (United States)

1996-03-01T23:59:59.000Z

246

Characterization of mouse UDP-glucose pyrophosphatase, a Nudix hydrolase encoded by the Nudt14 gene  

SciTech Connect (OSTI)

Recombinant mouse UDP-glucose pyrophosphatase (UGPPase), encoded by the Nudt14 gene, was produced in Escherichia coli and purified close to homogeneity. The enzyme catalyzed the conversion of [{beta}-{sup 32}P]UDP-glucose to [{sup 32}P]glucose-1-P and UMP, confirming that it hydrolyzed the pyrophosphate of the nucleoside diphosphate sugar to generate glucose-1-P and UMP. The enzyme was also active toward ADP-ribose. Activity is dependent on the presence of Mg{sup 2+} and was greatest at alkaline pH above 8. Kinetic analysis indicated a K{sub m} of {approx}4 mM for UDP-glucose and {approx}0.3 mM for ADP-ribose. Based on V{sub max}/K{sub m} values, the enzyme was {approx}20-fold more active toward ADP-ribose. UGPPase behaves as a dimer in solution and can be cross-linked to generate a species of M{sub r} 54,000 from a monomer of 30,000 as judged by SDS-PAGE. The dimerization was not affected by the presence of glucose-1-P or UDP-glucose. Using antibodies raised against the recombinant protein, Western analysis indicated that UGPPase was widely expressed in mouse tissues, including skeletal muscle, liver, kidney, heart, lung, fat, heart and pancreas with a lower level in brain. It was generally present as a doublet when analyzed by SDS-PAGE, suggesting the occurrence of some form of post-translational modification. Efforts to interconvert the species by adding or inhibiting phosphatase activity were unsuccessful, leaving the nature of the modification unknown. Sequence alignments and database searches revealed related proteins in species as distant as Drosophila melanogaster and Caenorhabditis elegans.

Heyen, Candy A.; Tagliabracci, Vincent S.; Zhai, Lanmin [Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 (United States)] [Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 (United States); Roach, Peter J., E-mail: proach@iupui.edu [Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 (United States)

2009-12-25T23:59:59.000Z

247

Effects of the co-carcinogen catechol on benzo(a)pyrene metabolism and DNA adduct formation in mouse skin  

SciTech Connect (OSTI)

We have studied the effects of the co-carcinogen catechol (1,2-dihydroxybenzene) on the metabolic activation of (/sup 3/H) benzo(a)pyrene (BaP) in mouse skin, in vivo and on the binding of BaP metabolites to DNA and protein at intervals from 0.5-24 h. Upon topical application of 0.015 mg (/sup 3/H)BaP and 0.25 or 0.5 mg catechol per mouse, catechol had little effect on the total amount of (/sup 3/H)BaP metabolized in mouse skin, but it affected the relative proportions of (/sup 3/H)BaP metabolites. Catechol (0.5 mg/mouse) decreased the proportion of water-soluble (/sup 3/H)BaP metabolites, ethyl acetate-soluble polar metabolites and quinones, but doubled the levels of unconjugated 3-hydroxy-BaP at all measured intervals after treatment. Catechol also caused a small increase in the levels of trans-7,8-dihydroxy-7,8-dihydroBaP and trans-9,10-dihydroxy-9,10-dihydroBaP 0.5 h after treatment. Two hours after treatment, the levels of these metabolites subsided to those of the controls. Catechol did not affect the levels of glutathione conjugates of BaP. However, it caused a decrease in glucuronide and sulphate conjugate formation from BaP. Catechol caused an approximately 2-fold increase in the formation of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydroBaP (BPDE) DNA adducts and elevated the ratio of anti-syn-BPDE-DNA adducts 1.6 to 2.9-fold. Catechol treatment increased the radioactivity associated with epidermal proteins after (/sup 3/H)BaP application. Because catechol increased levels of 3-hydroxyBaP, we considered the possibility that 3-hydroxyBaP might enhance the tumor initiating activities of BaP or BPDE in mouse skin; a bioassay demonstrated that this was not the case. The results of this study indicate that one important effect of catechol related to its co-carcinogenicity is its ability to enhance formation of anti-BPDE-DNA adducts in mouse skin.

Melikian, A.A.; Leszczynska, J.M.; Hecht, S.S.; Hoffmann, D.

1986-01-01T23:59:59.000Z

248

MicroRNAs in early embryonic development : dissecting the role of miR-290 through miR-295 in the mouse  

E-Print Network [OSTI]

MicroRNAs mediate developmental regulation of gene expression via translational repression of target mRNAs. Targeted deletion of the miRNA biogenesis machinery in the mouse has demonstrated essential roles for miRNAs during ...

Dennis, Lucas M

2008-01-01T23:59:59.000Z

249

A Novel Role of the WNT-Dishevelled-GSK3? Signaling Cascade in the Mouse Nucleus Accumbens in a Social Defeat Model of Depression  

E-Print Network [OSTI]

Based on earlier gene expression and chromatin array data, we identified the protein, dishevelled (DVL)-2, as being regulated in the nucleus accumbens (NAc), a key brain reward region, in the mouse social defeat model of ...

Wilkinson, Matthew B.

250

Visualization of nitric oxide production in the mouse main olfactory bulb by a cell-trappable copper(II) fluorescent probe  

E-Print Network [OSTI]

We report the visualization of NO production using fluorescence in tissue slices of the mouse main olfactory bulb. This discovery was possible through the use of a novel, cell-trappable probe for intracellular nitric oxide ...

McQuade, Lindsey E.

251

Effect of mechanical processing and heat treatment of powders on their sinterability characteristics linked with their method of manufacture. IV. The v/v vs tau function in a temperature jump in the sintering of porous bodies from molybdenum and tungsten carbide powders  

SciTech Connect (OSTI)

Use was made of molybdenum and tungsten carbide powders, which exhibit fairly high densification rates. The main object of the sintering of specimens from a molybdenum powder was to find out to what extent the behavior in a temperature jump of a metal differing markedly in physical properties (and electronic shell structure) from the metals investigated earlier resembled or differed from that of those metals. A molybdenum powder produced by the reduction of molybdenum trioxide with hydrogen at 800 C was chosen for investigation and experiments with tungsten carbide were carried out on two batches of powders produced at low and high carbidization temperatures. The study showed that the behavior of a porous specimen from the molybdenum powder did not differ from that of other metal powders. The behavior of tungsten carbide specimens in a temperature jump was similar to that of the metal powders studied in a previous investigation.

Ivensen, V.A.

1986-04-01T23:59:59.000Z

252

Proteomic profiling of brain cortex tissues in a Tau transgenic mouse model of Alzheimer's disease  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer A transgenic mouse model expressing NSE-htau23 was used. Black-Right-Pointing-Pointer 2D-gel electrophoresis to analyze the cortex proteins of transgenic mice was used. Black-Right-Pointing-Pointer Differentially expressed spots in different stages of AD were identified. Black-Right-Pointing-Pointer GSTP1 and CAII were downregulated with the progression of AD. Black-Right-Pointing-Pointer SCRN1 and ATP6VE1 were up regulated and down regulated differentially. -- Abstract: Alzheimer's disease (AD) involves regionalized neuronal death, synaptic loss, and an accumulation of intracellular neurofibrillary tangles and extracellular senile plaques. Although there have been numerous studies on tau proteins and AD in various stages of neurodegenerative disease pathology, the relationship between tau and AD is not yet fully understood. A transgenic mouse model expressing neuron-specific enolase (NSE)-controlled human wild-type tau (NSE-htau23), which displays some of the typical Alzheimer-associated pathological features, was used to analyze the brain proteome associated with tau tangle deposition. Two-dimensional electrophoresis was performed to compare the cortex proteins of transgenic mice (6- and 12-month-old) with those of control mice. Differentially expressed spots in different stages of AD were identified with ESI-Q-TOF (electrospray ionization quadruple time-of-flight) mass spectrometry and liquid chromatography/tandem mass spectrometry. Among the identified proteins, glutathione S-transferase P 1 (GSTP1) and carbonic anhydrase II (CAII) were down-regulated with the progression of AD, and secerin-1 (SCRN1) and V-type proton ATPase subunit E 1 (ATP6VE1) were up-regulated only in the early stages, and down-regulated in the later stages of AD. The proteins, which were further confirmed by RT-PCR at the mRNA level and with western blotting at the protein level, are expected to be good candidates as drug targets for AD. The study of up- and down-regulation of proteins during the progression of AD helps to explain the mechanisms associated with neuronal degeneration in AD.

Chang, Seong-Hun; Jung, In-Soo; Han, Gi-Yeon; Kim, Nam-Hee; Kim, Hyun-Jung [School of Life Sciences and Biotechnology, Korea University, Seoul 136-701 (Korea, Republic of)] [School of Life Sciences and Biotechnology, Korea University, Seoul 136-701 (Korea, Republic of); Kim, Chan-Wha, E-mail: cwkim@korea.ac.kr [School of Life Sciences and Biotechnology, Korea University, Seoul 136-701 (Korea, Republic of)] [School of Life Sciences and Biotechnology, Korea University, Seoul 136-701 (Korea, Republic of)

2013-01-11T23:59:59.000Z

253

Multi-walled carbon nanotube-induced gene expression in the mouse lung: Association with lung pathology  

SciTech Connect (OSTI)

Due to the fibrous shape and durability of multi-walled carbon nanotubes (MWCNT), concerns regarding their potential for producing environmental and human health risks, including carcinogenesis, have been raised. This study sought to investigate how previously identified lung cancer prognostic biomarkers and the related cancer signaling pathways are affected in the mouse lung following pharyngeal aspiration of well-dispersed MWCNT. A total of 63 identified lung cancer prognostic biomarker genes and major signaling biomarker genes were analyzed in mouse lungs (n = 80) exposed to 0, 10, 20, 40, or 80 {mu}g of MWCNT by pharyngeal aspiration at 7 and 56 days post-exposure using quantitative PCR assays. At 7 and 56 days post-exposure, a set of 7 genes and a set of 11 genes, respectively, showed differential expression in the lungs of mice exposed to MWCNT vs. the control group. Additionally, these significant genes could separate the control group from the treated group over the time series in a hierarchical gene clustering analysis. Furthermore, 4 genes from these two sets of significant genes, coiled-coil domain containing-99 (Ccdc99), muscle segment homeobox gene-2 (Msx2), nitric oxide synthase-2 (Nos2), and wingless-type inhibitory factor-1 (Wif1), showed significant mRNA expression perturbations at both time points. It was also found that the expression changes of these 4 overlapping genes at 7 days post-exposure were attenuated at 56 days post-exposure. Ingenuity Pathway Analysis (IPA) found that several carcinogenic-related signaling pathways and carcinogenesis itself were associated with both the 7 and 11 gene signatures. Taken together, this study identifies that MWCNT exposure affects a subset of lung cancer biomarkers in mouse lungs. - Research Highlights: > Multi-Walled Carbon Nanotubes affect lung cancer biomarkers in mouse lungs. > The results suggest potentially harmful effects of MWCNT exposure on human lungs. > The results could potentially be used for the medical surveillance of workers.

Pacurari, M. [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Qian, Y., E-mail: yaq2@cdc.gov [Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Porter, D.W.; Wolfarth, M. [Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Wan, Y.; Luo, D. [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Ding, M. [Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Castranova, V. [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Guo, N.L., E-mail: lguo@hsc.wvu.edu [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Department of Community Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506-9190 (United States)

2011-08-15T23:59:59.000Z

254

A physiologically based pharmacokinetic model for atrazine and its main metabolites in the adult male C57BL/6 mouse  

SciTech Connect (OSTI)

Atrazine (ATR) is a chlorotriazine herbicide that is widely used and relatively persistent in the environment. In laboratory rodents, excessive exposure to ATR is detrimental to the reproductive, immune, and nervous systems. To better understand the toxicokinetics of ATR and to fill the need for a mouse model, a physiologically based pharmacokinetic (PBPK) model for ATR and its main chlorotriazine metabolites (Cl-TRIs) desethyl atrazine (DE), desisopropyl atrazine (DIP), and didealkyl atrazine (DACT) was developed for the adult male C57BL/6 mouse. Taking advantage of all relevant and recently made available mouse-specific data, a flow-limited PBPK model was constructed. The ATR and DACT sub-models included blood, brain, liver, kidney, richly and slowly perfused tissue compartments, as well as plasma protein binding and red blood cell binding, whereas the DE and DIP sub-models were constructed as simple five-compartment models. The model adequately simulated plasma levels of ATR and Cl-TRIs and urinary dosimetry of Cl-TRIs at four single oral dose levels (250, 125, 25, and 5 mg/kg). Additionally, the model adequately described the dose dependency of brain and liver ATR and DACT concentrations. Cumulative urinary DACT amounts were accurately predicted across a wide dose range, suggesting the model's potential use for extrapolation to human exposures by performing reverse dosimetry. The model was validated using previously reported data for plasma ATR and DACT in mice and rats. Overall, besides being the first mouse PBPK model for ATR and its Cl-TRIs, this model, by analogy, provides insights into tissue dosimetry for rats. The model could be used in tissue dosimetry prediction and as an aid in the exposure assessment to this widely used herbicide.

Lin Zhoumeng [Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602 (United States); Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602 (United States); Fisher, Jeffrey W. [Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602 (United States); Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA 30602 (United States); Ross, Matthew K. [Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762 (United States); Filipov, Nikolay M., E-mail: filipov@uga.edu [Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602 (United States); Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602 (United States)

2011-02-15T23:59:59.000Z

255

Induction of chloride secretory currents across mouse ileal tissues by rotavirus enterotoxic peptide in different age mice  

E-Print Network [OSTI]

INDUCTION OF CHLORIDE SECRETORY CURRENTS ACROSS MOUSE ILEAL TISSUES BY A ROTAVIRUS ENTEROTOXIC PEPTIDE IN DIFFERENT AGE MICE A Thesis by VIRGINIA WATERS COX Submitted to the Office of Graduate Studies of Texas Ak M University in partial... by VIRGINIA WATERS COX Submitted to Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved as to style and content by: Judith M. Ball (Chair of Committee) Julian Lei os z (Member) Friedhelm...

Cox, Virginia Waters

2002-01-01T23:59:59.000Z

256

Effects of dietary eicosapentaenoic acid and docosahexaenoic acid on mouse T-lymphocyte function and diglyceride formation  

E-Print Network [OSTI]

. Edwards (Interim Department Head) December 1992 ABSTRACT Effects of Dietary Eicosapentaenoic Acid and Docosahexaenoic Acid on Mouse T-Lymphocyte Function and Diglyceride Formation. (December 1992) Kara Hosack Fowler, B. S. , Texas A&%M University..., coupled to CD3, a mediator which acts in stimulation to bind to phospholipase C (PLC) (10). Mitogens act on the TCR-CD3 complex to stimulate phospholipase C and hydrolysis of phosphatidylinositol (100). This results in diacylglycerol (DAG) and inositol...

Fowler, Kara Hosack

1992-01-01T23:59:59.000Z

257

Proposed Transmission Towers Proposed New Substation Sites Proposed...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Course East East Minnehaha Minnehaha Park Park Green Green Mountain Mountain Park Park Green Green Meadows Meadows Golf Course Golf Course Camas Camas Meadows Meadows Golf Club...

258

Park Profiler/Jump Analyzer Practical method for determining terrain park jump performance  

E-Print Network [OSTI]

for best practices in terrain park management, design, maintenance, and operations to maximize user. Management II. Planning and Design III. Operations and Maintenance US Terrain Park Council #12;a. start. transition: 1. radial acceleration 1second x v0 above transition d

259

Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate  

SciTech Connect (OSTI)

Pretreatment of mice with the peroxisome proliferator clofibrate (CFB) protects against acetaminophen (APAP)-induced hepatotoxicity. Previous studies have shown that activation of the nuclear peroxisome proliferator activated receptor-alpha (PPAR{alpha}) is required for this effect. The present study utilizes gene expression profile analysis to identify potential pathways contributing to PPAR{alpha}-mediated hepatoprotection. Gene expression profiles were compared between wild type and PPAR{alpha}-null mice pretreated with vehicle or CFB (500 mg/kg, i.p., daily for 10 days) and then challenged with APAP (400 mg/kg, p.o.). Total hepatic RNA was isolated 4 h after APAP treatment and hybridized to Affymetrix Mouse Genome MGU74 v2.0 GeneChips. Gene expression analysis was performed utilizing GeneSpring (registered) software. Our analysis identified 53 genes of interest including vanin-1, cell cycle regulators, lipid-metabolizing enzymes, and aldehyde dehydrogenase 2, an acetaminophen binding protein. Vanin-1 could be important for CFB-mediated hepatoprotection because this protein is involved in the synthesis of cysteamine and cystamine. These are potent antioxidants capable of ameliorating APAP toxicity in rodents and humans. HPLC-ESI/MS/MS analysis of liver extracts indicates that enhanced vanin-1 gene expression results in elevated cystamine levels, which could be mechanistically associated with CFB-mediated hepatoprotection.

Moffit, Jeffrey S. [University of Connecticut, Department of Pharmaceutical Sciences, Storrs, CT (United States); Koza-Taylor, Petra H. [Pfizer, Inc., Groton Laboratories, Molecular and Investigative Toxicology, Groton, CT (United States); Holland, Ricky D. [National Center for Toxicological Research, Division of Systems Toxicology, Jefferson, AR (United States); Thibodeau, Michael S. [University of Connecticut, Department of Pharmaceutical Sciences, Storrs, CT (United States); Beger, Richard D. [National Center for Toxicological Research, Division of Systems Toxicology, Jefferson, AR (United States); Lawton, Michael P. [Pfizer, Inc., Groton Laboratories, Molecular and Investigative Toxicology, Groton, CT (United States); Manautou, Jose E. [University of Connecticut, Department of Pharmaceutical Sciences, Storrs, CT (United States)]. E-mail: jose.manautou@uconn.edu

2007-07-15T23:59:59.000Z

260

Insect GDNF:TTC fusion protein improves delivery of GDNF to mouse CNS  

SciTech Connect (OSTI)

With a view toward improving delivery of exogenous glial cell line-derived neurotrophic factor (GDNF) to CNS motor neurons in vivo, we evaluated the bioavailability and pharmacological activity of a recombinant GDNF:tetanus toxin C-fragment fusion protein in mouse CNS. Following intramuscular injection, GDNF:TTC but not recombinant GDNF (rGDNF) produced strong GDNF immunostaining within ventral horn cells of the spinal cord. Intrathecal infusion of GDNF:TTC resulted in tissue concentrations of GDNF in lumbar spinal cord that were at least 150-fold higher than those in mice treated with rGDNF. While levels of immunoreactive choline acetyltransferase and GFR{alpha}-1 in lumbar cord were not altered significantly by intrathecal infusion of rGNDF, GDNF:TTC, or TTC, only rGDNF and GDNF:TTC caused significant weight loss following intracerebroventricular infusion. These studies indicate that insect cell-derived GDNF:TTC retains its bi-functional activity in mammalian CNS in vivo and improves delivery of GDNF to spinal cord following intramuscular- or intrathecal administration.

Li, Jianhong; Chian, Ru-Ju; Ay, Ilknur; Kashi, Brenda B.; Celia, Samuel A.; Tamrazian, Eric [Cecil B. Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129 (United States)] [Cecil B. Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129 (United States); Pepinsky, R. Blake [BiogenIdec, Inc., 14 Cambridge Center, Cambridge, MA 02142 (United States)] [BiogenIdec, Inc., 14 Cambridge Center, Cambridge, MA 02142 (United States); Fishman, Paul S. [Research Service, Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201 (United States) [Research Service, Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201 (United States); Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201 (United States); Brown, Robert H. [Cecil B. Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129 (United States)] [Cecil B. Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129 (United States); Francis, Jonathan W., E-mail: jwfrancisby@gmail.com [Cecil B. Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129 (United States)

2009-12-18T23:59:59.000Z

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261

MSH regulation of tyrosinase in Cloudman S-91 mouse melanoma cell cultures  

SciTech Connect (OSTI)

Melanocyte Stimulating Hormone (MSH) causes an increase in tyrosinase activity (O-diphenol: O/sub 2/ oxidoreductase) in Cloudman S-91 mouse melanoma cell cultures following a lag period of approximately 9 hours. Treatment of cells with 2 x 10/sup -7/M ..cap alpha..- MSH for 6 days results in a 90 fold increase in the specific activity of the enzyme. The hormone mediated increase in tyrosinase activity is dependent upon continued transcription since the enzyme induction is suppressed by either cordycepin (1..mu..g/ml) or ..cap alpha..-amanitin (10..mu..g/ml). To determine if MSH is increasing the synthesis rate of tyrosinase, cell cultures, either exposed to MSH for various times or left untreated, were pulsed with (/sup 3/H)-leucine for 4 hours and tyrosinase immunoprecipitated with an anti-tyrosinase polyclonal antiserum raised in rabbits. The immunoprecipitates were solubilized and electrophoresed on SDS polyacrylamide gels. The proteins were electroblotted to nitrocellulose and the radioactivity in the tyrosinase bands determined. These studies have shown that while tyrosinase activity in hormone-treated cells may increase 90 fold, the rate of synthesis of the enzyme increases only 3 fold at most. Immunoprecipitation analysis of equivalence points of tyrosinase from control and MSH-treated cultures suggests the presence of inactive forms of the enzyme in melanoma cell cultures. These results suggest that, in addition to stimulating tyrosinase synthesis, MSH may also promote the activation of pre-existing enzyme molecules.

Fuller, B.B.

1986-05-01T23:59:59.000Z

262

Time-course comparison of xenobiotic activators of CAR and PPAR{alpha} in mouse liver  

SciTech Connect (OSTI)

Constitutive androstane receptor (CAR) and peroxisome proliferator activated receptor (PPAR){alpha} are transcription factors known to be primary mediators of liver effects, including carcinogenesis, by phenobarbital-like compounds and peroxisome proliferators, respectively, in rodents. Many similarities exist in the phenotypes elicited by these two classes of agents in rodent liver, and we hypothesized that the initial transcriptional responses to the xenobiotic activators of CAR and PPAR{alpha} will exhibit distinct patterns, but at later time-points these biological pathways will converge. In order to capture the global transcriptional changes that result from activation of these nuclear receptors over a time-course in the mouse liver, microarray technology was used. First, differences in basal expression of liver genes between C57Bl/6J wild-type and Car-null mice were examined and 14 significantly differentially expressed genes were identified. Next, mice were treated with phenobarbital (100 mg/kg by gavage for 24 h, or 0.085% w/w diet for 7 or 28 days), and liver gene expression changes with regards to both time and treatment were identified. While several pathways related to cellular proliferation and metabolism were affected by phenobarbital in wild-type mice, no significant changes in gene expression were found over time in the Car-nulls. Next, we determined commonalities and differences in the temporal response to phenobarbital and WY-14,643, a prototypical activator of PPAR {alpha}. Gene expression signatures from livers of wild-type mice C57Bl6/J mice treated with PB or WY-14,643 were compared. Similar pathways were affected by both compounds; however, considerable time-related differences were present. This study establishes common gene expression fingerprints of exposure to activators of CAR and PPAR{alpha} in rodent liver and demonstrates that despite similar phenotypic changes, molecular pathways differ between classes of chemical carcinogens.

Ross, Pamela K. [Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC (United States); Woods, Courtney G. [Hamner Institutes for Health Sciences, Research Triangle Park, NC (United States); ExxonMobil Biomedical Sciences, Annandale, NJ (United States); Bradford, Blair U.; Kosyk, Oksana; Gatti, Daniel M. [Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC (United States); Cunningham, Michael L. [National Institute for Environmental Health Sciences, Research Triangle Park, NC (United States); Rusyn, Ivan [Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC (United States)], E-mail: iir@unc.edu

2009-03-01T23:59:59.000Z

263

HumanWildlife Conflicts 3(1):89, Spring 2009 The Soap Box  

E-Print Network [OSTI]

of controlling wildlife were (1) the field success of poison against meadow mice during a Nevada mouse plague not be transmissible to other vertebrates. Because this was not successful, it searched for a poison bait or lethal gas that any accurate knowledge of the food habits of such pests and effective means for reducing their numbers

264

Dichlorodiphenyltrichloroethane technical mixture regulates cell cycle and apoptosis genes through the activation of CAR and ER? in mouse livers  

SciTech Connect (OSTI)

Dichlorodiphenyltrichloroethane (DDT) is a widely used organochlorine pesticide and a xenoestrogen that promotes rodent hepatomegaly and tumours. A recent study has shown significant correlation between DDT serum concentration and liver cancer incidence in humans, but the underlying mechanisms remain elusive. We hypothesised that a mixture of DDT isomers could exert effects on the liver through pathways instead of classical ERs. The acute effects of a DDT mixture containing the two major isomers p,p?-DDT (85%) and o,p?-DDT (15%) on CAR and ER? receptors and their cell cycle and apoptosis target genes were studied in mouse livers. ChIP results demonstrated increased CAR and ER? recruitment to their specific target gene binding sites in response to the DDT mixture. The results of real-time RT-PCR were consistent with the ChIP data and demonstrated that the DDT was able to activate both CAR and ER? in mouse livers, leading to target gene transcriptional increases including Cyp2b10, Gadd45?, cMyc, Mdm2, Ccnd1, cFos and E2f1. Western blot analysis demonstrated increases in cell cycle progression proteins cMyc, Cyclin D1, CDK4 and E2f1 and anti-apoptosis proteins Mdm2 and Gadd45?. In addition, DDT exposure led to Rb phosphorylation. Increases in cell cycle progression and anti-apoptosis proteins were accompanied by a decrease in p53 content and its transcriptional activity. However, the DDT was unable to stimulate the ?-catenin signalling pathway, which can play an important role in hepatocyte proliferation. Thus, our results indicate that DDT treatment may result in cell cycle progression and apoptosis inhibition through CAR- and ER?-mediated gene activation in mouse livers. These findings suggest that the proliferative and anti-apoptotic conditions induced by CAR and ER? activation may be important contributors to the early stages of hepatocarcinogenesis as produced by DDT in rodent livers. - Highlights: • DDT activated both CAR and ER? and their cell cycle and apoptosis target genes. • DDT produced increases in cell cycle and anti-apoptosis proteins and decrease in p53. • DDT mixture was unable to stimulate the ?-catenin signalling pathway in mouse livers.

Kazantseva, Yuliya A.; Yarushkin, Andrei A. [Institute of Molecular Biology and Biophysics SB RAMS, Novosibirsk, Timakova str., 2, 630117 (Russian Federation); Pustylnyak, Vladimir O., E-mail: pustylnyak@ngs.ru [Institute of Molecular Biology and Biophysics SB RAMS, Novosibirsk, Timakova str., 2, 630117 (Russian Federation); Novosibirsk State University, Novosibirsk, Pirogova str., 2, 630090 (Russian Federation)

2013-09-01T23:59:59.000Z

265

Automatic Seedpoint Selection and Tracing of Microstructures in the Knife-Edge Scanning Microscope Mouse Brain Data Set  

E-Print Network [OSTI]

in neuronal structures [4]. Research about the neuronal structure can also help understand how the neuronal structure processes information. In order to investigate neuronal structures, researchers at the Brain Network Lab (BNL) at Texas A&M University... by re- searchers at the Brain Network Laboratory (BNL) at Texas A&M University (TAMU) to scan entire mouse brains at a sub-micrometer resolution (down to 300 nm). This instrument consists of a high-precision stage, a diamond knife and an illuminator...

Kim, Dongkun

2011-10-21T23:59:59.000Z

266

Transient inhibition of cell proliferation does not compromise self-renewal of mouse embryonic stem cells  

SciTech Connect (OSTI)

Embryonic stem cells (ESCs) have unlimited capacity for self-renewal and can differentiate into various cell types when induced. They also have an unusual cell cycle control mechanism driven by constitutively active cyclin dependent kinases (Cdks). In mouse ESCs (mESCs). It is proposed that the rapid cell proliferation could be a necessary part of mechanisms that maintain mESC self-renewal and pluripotency, but this hypothesis is not in line with the finding in human ESCs (hESCs) that the length of the cell cycle is similar to differentiated cells. Therefore, whether rapid cell proliferation is essential for the maintenance of mESC state remains unclear. We provide insight into this uncertainty through chemical intervention of mESC cell cycle. We report here that inhibition of Cdks with olomoucine II can dramatically slow down cell proliferation of mESCs with concurrent down-regulation of cyclin A, B and E, and the activation of the Rb pathway. However, mESCs display can recover upon the removal of olomoucine II and are able to resume normal cell proliferation without losing self-renewal and pluripotency, as demonstrated by the expression of ESC markers, colony formation, embryoid body formation, and induced differentiation. We provide a mechanistic explanation for these observations by demonstrating that Oct4 and Nanog, two major transcription factors that play critical roles in the maintenance of ESC properties, are up-regulated via de novo protein synthesis when the cells are exposed to olomoucine II. Together, our data suggest that short-term inhibition of cell proliferation does not compromise the basic properties of mESCs. -- Highlights: Black-Right-Pointing-Pointer Inhibition of Cdks slows down mESCs proliferation. Black-Right-Pointing-Pointer mESCs display remarkable recovery capacity from short-term cell cycle interruption. Black-Right-Pointing-Pointer Short-term cell cycle interruption does not compromise mESC self-renewal. Black-Right-Pointing-Pointer Oct4 and Nanog are up-regulated via de novo synthesis by cell cycle interruption.

Wang, Ruoxing [Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive 5018, Hattiesburg, MS 39406 (United States)] [Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive 5018, Hattiesburg, MS 39406 (United States); Guo, Yan-Lin, E-mail: yanlin.guo@usm.edu [Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive 5018, Hattiesburg, MS 39406 (United States)] [Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive 5018, Hattiesburg, MS 39406 (United States)

2012-10-01T23:59:59.000Z

267

Slow elimination of phosphorylated histone {gamma}-H2AX from DNA of terminally differentiated mouse heart cells in situ  

SciTech Connect (OSTI)

Phosphorylation of replacement histone H2AX occurs in megabase chromatin domains around double-strand DNA breaks (DSBs) and this modification (called {gamma}-H2AX) may serve as a useful marker of genome damage and repair in terminally differentiated cells. Here using immunohistochemistry we studied kinetics of {gamma}-H2AX formation and elimination in the X-irradiated mouse heart and renal epithelial tissues in situ. Unirradiated tissues have 3-5% {gamma}-H2AX-positive cells and in tissues fixed 1 h after X-irradiation {gamma}-H2AX-positive nuclei are induced in a dose-dependent manner approaching 20-30% after 3 Gy of IR. Analysis of mouse tissues at different times after 3 Gy of IR showed that maximal induction of {gamma}-H2AX in heart is observed 20 min after IR and then is decreased slowly with about half remaining 23 h later. In renal epithelium maximum of the {gamma}-H2AX-positive cells is observed 40 min after IR and then decreases to control values in 23 h. This indicates that there are significant variations between non-proliferating mammalian tissues in the initial H2AX phosphorylation rate as well as in the rate of {gamma}-H2AX elimination after X-irradiation, which should be taken into account in the analysis of radiation responses.

Gavrilov, Boris [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation); Vezhenkova, Irina [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation); Firsanov, Denis [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation); Solovjeva, Liudmila [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation); Svetlova, Maria [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation); Mikhailov, Vyacheslav [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation); Tomilin, Nikolai [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation)]. E-mail: nvtom@hotmail.com

2006-09-08T23:59:59.000Z

268

Mandibular and Neural Crest Cell Deficits Seen in TsDn65 Down Syndrome Mouse Model Rescued By Green Tea Polyphenol, EGCG  

E-Print Network [OSTI]

to the mandibular deficit seen in E9.5 Ts65Dn embryos. We propose that EGCG, a green tea polyphenol, will inhibitMandibular and Neural Crest Cell Deficits Seen in TsDn65 Down Syndrome Mouse Model Rescued By Green Tea Polyphenol, EGCG Gracelyn C. Bose1 , Rachel A. Novack1 ,Danika M. Tumbleson1 , Alexis N. Chom1

Zhou, Yaoqi

269

The Teratogenic Sensitivity to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Is Modified by a Locus on Mouse Chromosome 3  

E-Print Network [OSTI]

- phrosis in developing mice exposed to the pollutant 2,3,7,8- tetrachlorodibenzo-p-dioxin (dioxin) is a prototype for the study of gene-environment interactions. Dioxin is an ubiquitous environmental pollutantThe Teratogenic Sensitivity to 2,3,7,8-Tetrachlorodibenzo-p- dioxin Is Modified by a Locus on Mouse

Bradfield, Christopher A.

270

Direct and indirect impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)1 on adult mouse Leydig cells: an in vitro study.2  

E-Print Network [OSTI]

1 Direct and indirect impact of 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD)1 on adult mouse Leydig,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related substances are ubiquitous22 environmental pollutants that exert words: Dioxin; Leydig cell; in vitro; AhR; chemokine39 40 inserm-00816472,version1-22Apr2013 #12;3 1

Paris-Sud XI, Université de

271

Systematic implications of mtDNA sequence variation in a deer mouse species endemic to islands in the Gulf of California  

E-Print Network [OSTI]

validity, systematic relationships and geographic origin of P. sejugis, a species of deer mouse endemic to two islands in the Gulf of California. To determine genetic affinities, sequence variation was analyzed for a 1,439 base pair region (ND3/ND4L/ND4...

Moore, Ashli Francille

2013-02-22T23:59:59.000Z

272

Local volume changes of the corpus callosum from 3D MR images of wildtype and knockout mouse brains G. Hamarneh1  

E-Print Network [OSTI]

CC from the MR images (Figure 1a) using Livewire, a semi-automatic segmentation tool provided by AmiraLocal volume changes of the corpus callosum from 3D MR images of wildtype and knockout mouse brains G. Hamarneh1 , J. Chen1 , N. Lifshitz1 , J. Henderson2 , M. Henkelman1 1 Hospital for Sick Children

Hamarneh, Ghassan

273

Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord  

E-Print Network [OSTI]

Defaults in vascular (VN) and neuronal networks of spinal cord are responsible for serious neurodegenerative pathologies. Because of inadequate investigation tools, the lacking knowledge of the complete fine structure of VN and neuronal systems is a crucial problem. Conventional 2D imaging yields incomplete spatial coverage leading to possible data misinterpretation, whereas standard 3D computed tomography imaging achieves insufficient resolution and contrast. We show that X-ray high-resolution phase-contrast tomography allows the simultaneous visualization of three-dimensional VN and neuronal systems of mouse spinal cord at scales spanning from millimeters to hundreds of nanometers, with neither contrast agent nor a destructive sample-preparation. We image both the 3D distribution of micro-capillary network and the micrometric nerve fibers, axon-bundles and neuron soma. Our approach is a crucial tool for pre-clinical investigation of neurodegenerative pathologies and spinal-cord-injuries. In particular, it s...

Fratini, Michela; Campi, Gaetano; Brun, Francesco; Tromba, Giuliana; Modregger, Peter; Bucci, Domenico; Battaglia, Giuseppe; Spadon, Raffaele; Mastrogiacomo, Maddalena; Requardt, Herwig; Giove, Federico; Bravin, Alberto; Cedola, Alessia

2014-01-01T23:59:59.000Z

274

Differential gene expression profiling of mouse skin after sulfur mustard exposure: Extended time response and inhibitor effect  

SciTech Connect (OSTI)

Sulfur mustard (HD, SM), is a chemical warfare agent that within hours causes extensive blistering at the dermal-epidermal junction of skin. To better understand the progression of SM-induced blistering, gene expression profiling for mouse skin was performed after a single high dose of SM exposure. Punch biopsies of mouse ears were collected at both early and late time periods following SM exposure (previous studies only considered early time periods). The biopsies were examined for pathological disturbances and the samples further assayed for gene expression profiling using the Affymetrix microarray analysis system. Principal component analysis and hierarchical cluster analysis of the differently expressed genes, performed with ArrayTrack showed clear separation of the various groups. Pathway analysis employing the KEGG library and Ingenuity Pathway Analysis (IPA) indicated that cytokine-cytokine receptor interaction, cell adhesion molecules (CAMs), and hematopoietic cell lineage are common pathways affected at different time points. Gene ontology analysis identified the most significantly altered biological processes as the immune response, inflammatory response, and chemotaxis; these findings are consistent with other reported results for shorter time periods. Selected genes were chosen for RT-PCR verification and showed correlations in the general trends for the microarrays. Interleukin 1 beta was checked for biological analysis to confirm the presence of protein correlated to the corresponding microarray data. The impact of a matrix metalloproteinase inhibitor, MMP-2/MMP-9 inhibitor I, against SM exposure was assessed. These results can help in understanding the molecular mechanism of SM-induced blistering, as well as to test the efficacy of different inhibitors.

Gerecke, Donald R. [Environmental and Occupational Health Sciences Institute (EOHSI), a Joint Institute of UMDNJ-RW Johnson Medical School and Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854 (United States)], E-mail: gerecke@eohsi.rutgers.edu; Chen Minjun; Isukapalli, Sastry S.; Gordon, Marion K.; Chang, Y.-C. [Environmental and Occupational Health Sciences Institute (EOHSI), Joint Institute of UMDNJ-RW Johnson Medical School and Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854 (United States); Tong Weida [US FDA, National Center for Toxicological Research, Jefferson, AK (United States); Androulakis, Ioannis P. [Department of Biomedical Engineering, Rutgers, State University of New Jersey, Piscataway, NJ (United States); Georgopoulos, Panos G. [Environmental and Occupational Health Sciences Institute (EOHSI), Joint Institute of UMDNJ-RW Johnson Medical School and Rutgers University, 170 Frelinghuysen Road, Piscataway, NJ 08854 (United States)

2009-01-15T23:59:59.000Z

275

Chondroregulatory action of prolactin on proliferation and differentiation of mouse chondrogenic ATDC5 cells in 3-dimensional micromass cultures  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer Mouse chondrogenic ATDC5 cells expressed PRL receptor mRNAs and proteins. Black-Right-Pointing-Pointer Low PRL concentration (10 ng/mL) increased chondrocyte viability and differentiation. Black-Right-Pointing-Pointer Higher PRL concentrations ( Greater-Than-Or-Slanted-Equal-To 100 ng/mL) decreased viability and increased apoptosis. -- Abstract: A recent investigation in lactating rats has provided evidence that the lactogenic hormone prolactin (PRL) increases endochondral bone growth and bone elongation, presumably by accelerating apoptosis of hypertrophic chondrocytes in the growth plate and/or subsequent chondrogenic matrix mineralization. Herein, we demonstrated the direct chondroregulatory action of PRL on proliferation, differentiation and apoptosis of chondrocytes in 3-dimensional micromass culture of mouse chondrogenic ATDC5 cell line. The results showed that ATDC5 cells expressed PRL receptor (PRLR) transcripts, and responded typically to PRL by downregulating PRLR expression. Exposure to a low PRL concentration of 10 ng/mL, comparable to the normal levels in male and non-pregnant female rats, increased chondrocyte viability, differentiation, proteoglycan accumulation, and mRNA expression of several chondrogenic differentiation markers, such as Sox9, ALP and Hspg2. In contrast, high PRL concentrations of Greater-Than-Or-Slanted-Equal-To 100 ng/mL, comparable to the levels in pregnancy or lactation, decreased chondrocyte viability by inducing apoptosis, with no effect on chondrogenic marker expression. It could be concluded that chondrocytes directly but differentially responded to non-pregnant and pregnant/lactating levels of PRL, thus suggesting the stimulatory effect of PRL on chondrogenesis in young growing individuals, and supporting the hypothesis of hypertrophic chondrocyte apoptosis in the growth plate of lactating rats.

Seriwatanachai, Dutmanee [Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol University, Bangkok (Thailand)] [Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol University, Bangkok (Thailand); Krishnamra, Nateetip [Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol University, Bangkok (Thailand) [Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol University, Bangkok (Thailand); Department of Physiology, Faculty of Science, Mahidol University, Bangkok (Thailand); Charoenphandhu, Narattaphol, E-mail: naratt@narattsys.com [Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol University, Bangkok (Thailand) [Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol University, Bangkok (Thailand); Department of Physiology, Faculty of Science, Mahidol University, Bangkok (Thailand)

2012-03-30T23:59:59.000Z

276

A Novel mouse model of enhanced proteostasis: Full-length human heat shock factor 1 transgenic mice  

SciTech Connect (OSTI)

Research highlights: {yields} Development of mouse overexpressing native human HSF1 in all tissues including CNS. {yields} HSF1 overexpression enhances heat shock response at whole-animal and cellular level. {yields} HSF1 overexpression protects from polyglutamine toxicity and favors aggresomes. {yields} HSF1 overexpression enhances proteostasis at the whole-animal and cellular level. -- Abstract: The heat shock response (HSR) is controlled by the master transcriptional regulator heat shock factor 1 (HSF1). HSF1 maintains proteostasis and resistance to stress through production of heat shock proteins (HSPs). No transgenic model exists that overexpresses HSF1 in tissues of the central nervous system (CNS). We generated a transgenic mouse overexpressing full-length non-mutant HSF1 and observed a 2-4-fold increase in HSF1 mRNA and protein expression in all tissues studied of HSF1 transgenic (HSF1{sup +/0}) mice compared to wild type (WT) littermates, including several regions of the CNS. Basal expression of HSP70 and 90 showed only mild tissue-specific changes; however, in response to forced exercise, the skeletal muscle HSR was more elevated in HSF1{sup +/0} mice compared to WT littermates and in fibroblasts following heat shock, as indicated by levels of inducible HSP70 mRNA and protein. HSF1{sup +/0} cells elicited a significantly more robust HSR in response to expression of the 82 repeat polyglutamine-YFP fusion construct (Q82YFP) and maintained proteasome-dependent processing of Q82YFP compared to WT fibroblasts. Overexpression of HSF1 was associated with fewer, but larger Q82YFP aggregates resembling aggresomes in HSF1{sup +/0} cells, and increased viability. Therefore, our data demonstrate that tissues and cells from mice overexpressing full-length non-mutant HSF1 exhibit enhanced proteostasis.

Pierce, Anson, E-mail: piercea2@uthscsa.edu [Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States) [Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); The Department of Veteran's Affairs, South Texas Veterans Health Care System, San Antonio, Texas, 78284 (United States); Wei, Rochelle; Halade, Dipti [Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States)] [Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); Yoo, Si-Eun [Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States) [Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); Ran, Qitao; Richardson, Arlan [Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States) [Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); The Department of Veteran's Affairs, South Texas Veterans Health Care System, San Antonio, Texas, 78284 (United States)

2010-11-05T23:59:59.000Z

277

Mode of Action and Pharmacokinetic Studies of 2-Butoxyethanol in the Mouse with an Emphasis on Forestomach Dosimetry  

SciTech Connect (OSTI)

Chronic inhalation studies with 2-butoxyethanol conducted by National Toxicology Program identified the forestomach and liver of B6C3F1 mice as target organs for tumorigenicity. Previous studies have sown that liver tumors likely results from chronic hemolysis-induced oxidative stress. For forestomach lesions see in mice, chronic contact irritation (cytotoxicity) and regenerative hyperplasia are hypothesized to result in forestomach tumor development. To test this, experiments were conducted to address the sensitivity of mouse forestomach to BE administered by various routes. Oral administration of undiluted BE was shown to cause irritation and a compensatory proliferative response in mouse forestomach confirming that direct contact between forestomach and BE can cause irritation. However, only small amounts of BE were detected on fur of mice at the end of 6-h, whole-body or nose-only inhalation exposures to highest concentration used in the NTP chromic inhalation studies. Furthermore, no significant differences were detected in end-exposure blood concentrations of BE and butoxyacetic acid between these types of exposures. In addition, parenteral administration of BE also resulted in forestomach lesions, indicating there may be sources other than grooming for BE- or BAA-induced forestomach irritation. In pharmacokinetic study, BE and to a lesser extend BAA were eliminated more slowly from the forestomach tissue of mice than from blood or other tissues, following either oral gavage or ip injection. The forestomach was the only tissue with detectable levels of BE at 24 h. BE and BAA were both excreted in the saliva and were present in stomach contents for a prolong period of time following these routes of exposure which may further contribute to forestomach tissue dosimetry. Thus, there appear to be multiple mechanisms behind the increased levels of BE and BAA in the forestomach tissue of mice, which together can contribute to a prolong contact irritation, compensatory hyperplasia, and tumorigenicity in mice. The relevant of these effects in humans, who lack a forestomach, is questioned.

Poet, Torka S.; Soelberg, Jolen J.; Weitz, Karl K.; Mast, Terryl J.; Miller, Rodney A.; Thrall, Brian D.; Corley, Rick A.

2003-02-01T23:59:59.000Z

278

Functional Analysis of the Mouse Scn8a Sodium Channel Marianne R. Smith,1 Raymond D. Smith,1 Nicholas W. Plummer,2 Miriam H. Meisler,2 and Alan L. Goldin1  

E-Print Network [OSTI]

Functional Analysis of the Mouse Scn8a Sodium Channel Marianne R. Smith,1 Raymond D. Smith,1 modulate the electrophysiological properties of the channels (Isom et al., 1992, 1995; Smith and Goldin

Goldin, Alan L.

279

Ortho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes  

SciTech Connect (OSTI)

2'-3-dimethyl-4-aminoazobenzene (ortho-aminoazotoluene, OAT) is an azo dye and a rodent carcinogen that has been evaluated by the International Agency for Research on Cancer (IARC) as a possible (class 2B) human carcinogen. Its mechanism of action remains unclear. We examined the role of the xenobiotic receptor Constitutive Androstane Receptor (CAR, NR1I3) as a mediator of the effects of OAT. We found that OAT increases mouse CAR (mCAR) transactivation in a dose-dependent manner. This effect is specific because another closely related azo dye, 3'-methyl-4-dimethyl-aminoazobenzene (3'MeDAB), did not activate mCAR. Real-time Q-PCR analysis in wild-type C57BL/6 mice revealed that OAT induces the hepatic mRNA expression of the following CAR target genes: Cyp2b10, Cyp2c29, Cyp3a11, Ugt1a1, Mrp4, Mrp2 and c-Myc. CAR-null (Car{sup -/-}) mice showed no increased expression of these genes following OAT treatment, demonstrating that CAR is required for their OAT dependent induction. The OAT-induced CAR-dependent increase of Cyp2b10 and c-Myc expression was confirmed by Western blotting. Immunohistochemistry analysis of wild-type and Car{sup -/-} livers showed that OAT did not acutely induce hepatocyte proliferation, but at much later time points showed an unexpected CAR-dependent proliferative response. These studies demonstrate that mCAR is an OAT xenosensor, and indicate that at least some of the biological effects of this compound are mediated by this nuclear receptor. - Highlights: > The azo dye and mouse carcinogen OAT is a very effective mCAR activator. > OAT increases mCAR transactivation in a dose-dependent manner. > OAT CAR-dependently increases the expression of a specific subset of CAR target genes. > OAT induces an unexpectedly deferred, but CAR-dependent hepatocyte proliferation.

Smetanina, Mariya A., E-mail: maria.smetanina@gmail.com [Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030 (United States); Laboratory of Gene Expression Control, Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, prospekt Lavrentyeva 10, Novosibirsk 630090 (Russian Federation); Group of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences, prospekt Lavrentyeva 8, Novosibirsk 630090 (Russian Federation); Pakharukova, Mariya Y. [Laboratory of Gene Expression Control, Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, prospekt Lavrentyeva 10, Novosibirsk 630090 (Russian Federation); Kurinna, Svitlana M. [Department of Biochemistry and Molecular Biology, Unit 1000, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030 (United States); Dong, Bingning; Hernandez, Juan P.; Moore, David D. [Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030 (United States); Merkulova, Tatyana I. [Laboratory of Gene Expression Control, Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, prospekt Lavrentyeva 10, Novosibirsk 630090 (Russian Federation)

2011-08-15T23:59:59.000Z

280

Sodium fluoride induces apoptosis in mouse embryonic stem cells through ROS-dependent and caspase- and JNK-mediated pathways  

SciTech Connect (OSTI)

Sodium fluoride (NaF) is used as a source of fluoride ions in diverse applications. Fluoride salt is an effective prophylactic for dental caries and is an essential element required for bone health. However, fluoride is known to cause cytotoxicity in a concentration-dependent manner. Further, no information is available on the effects of NaF on mouse embryonic stem cells (mESCs). We investigated the mode of cell death induced by NaF and the mechanisms involved. NaF treatment greater than 1 mM reduced viability and DNA synthesis in mESCs and induced cell cycle arrest in the G{sub 2}/M phase. The addition of NaF induced cell death mainly by apoptosis rather than necrosis. Catalase (CAT) treatment significantly inhibited the NaF-mediated cell death and also suppressed the NaF-mediated increase in phospho-c-Jun N-terminal kinase (p-JNK) levels. Pre-treatment with SP600125 or z-VAD-fmk significantly attenuated the NaF-mediated reduction in cell viability. In contrast, intracellular free calcium chelator, but not of sodium or calcium ion channel blockers, facilitated NaF-induced toxicity in the cells. A JNK specific inhibitor (SP600125) prevented the NaF-induced increase in growth arrest and the DNA damage-inducible protein 45?. Further, NaF-mediated loss of mitochondrial membrane potential was apparently inhibited by pifithrin-? or CAT inhibitor. These findings suggest that NaF affects viability of mESCs in a concentration-dependent manner, where more than 1 mM NaF causes apoptosis through hydroxyl radical-dependent and caspase- and JNK-mediated pathways. -- Highlights: ? The mode of NaF-induced cell death and the mechanisms involved were examined. ? NaF induced mainly apoptotic death of mouse embryonic stem cells (mESCs). ? NaF induced mitochondrial-mediated and caspase-dependent apoptosis. ? JNK- and p53-mediated pathways are involved in NaF-mediated apoptosis in the cells. ? ROS are the up-stream effector in NaF-mediated activation of JNK and p53 in mESCs.

Nguyen Ngoc, Tam Dan [Institute of Oral Biosciences and School of Dentistry (BK21 Program), Chonbuk National University, Jeonju 561-756 (Korea, Republic of)] [Institute of Oral Biosciences and School of Dentistry (BK21 Program), Chonbuk National University, Jeonju 561-756 (Korea, Republic of); Son, Young-Ok [Graduate Center for Toxicology, School of Medicine, University of Kentucky, Lexington, KY 40536-0305 (United States)] [Graduate Center for Toxicology, School of Medicine, University of Kentucky, Lexington, KY 40536-0305 (United States); Lim, Shin-Saeng [Institute of Oral Biosciences and School of Dentistry (BK21 Program), Chonbuk National University, Jeonju 561-756 (Korea, Republic of) [Institute of Oral Biosciences and School of Dentistry (BK21 Program), Chonbuk National University, Jeonju 561-756 (Korea, Republic of); Department of Bioactive Material Sciences and Research Center of Bioactive Materials, Chonbuk National University, Jeonju 561-756 (Korea, Republic of); Shi, Xianglin [Graduate Center for Toxicology, School of Medicine, University of Kentucky, Lexington, KY 40536-0305 (United States)] [Graduate Center for Toxicology, School of Medicine, University of Kentucky, Lexington, KY 40536-0305 (United States); Kim, Jong-Ghee [Institute of Oral Biosciences and School of Dentistry (BK21 Program), Chonbuk National University, Jeonju 561-756 (Korea, Republic of)] [Institute of Oral Biosciences and School of Dentistry (BK21 Program), Chonbuk National University, Jeonju 561-756 (Korea, Republic of); Heo, Jung Sun [Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701 (Korea, Republic of)] [Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701 (Korea, Republic of); Choe, Youngji [Institute of Oral Biosciences and School of Dentistry (BK21 Program), Chonbuk National University, Jeonju 561-756 (Korea, Republic of)] [Institute of Oral Biosciences and School of Dentistry (BK21 Program), Chonbuk National University, Jeonju 561-756 (Korea, Republic of); Jeon, Young-Mi, E-mail: young@jbnu.ac.kr [Institute of Oral Biosciences and School of Dentistry (BK21 Program), Chonbuk National University, Jeonju 561-756 (Korea, Republic of)] [Institute of Oral Biosciences and School of Dentistry (BK21 Program), Chonbuk National University, Jeonju 561-756 (Korea, Republic of); Lee, Jeong-Chae, E-mail: leejc88@jbnu.ac.kr [Institute of Oral Biosciences and School of Dentistry (BK21 Program), Chonbuk National University, Jeonju 561-756 (Korea, Republic of) [Institute of Oral Biosciences and School of Dentistry (BK21 Program), Chonbuk National University, Jeonju 561-756 (Korea, Republic of); Graduate Center for Toxicology, School of Medicine, University of Kentucky, Lexington, KY 40536-0305 (United States); Department of Bioactive Material Sciences and Research Center of Bioactive Materials, Chonbuk National University, Jeonju 561-756 (Korea, Republic of)

2012-03-15T23:59:59.000Z

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281

2,6-Dithiopurine, a nucleophilic scavenger, protects against mutagenesis in mouse skin treated in vivo with 2-(chloroethyl) ethyl sulfide, a mustard gas analog  

SciTech Connect (OSTI)

Sulfur mustard [bis(2-chloroethyl)sulfide, SM] is a well-known DNA-damaging agent that has been used in chemical warfare since World War I, and is a weapon that could potentially be used in a terrorist attack on a civilian population. Dermal exposure to high concentrations of SM produces severe, long-lasting burns. Topical exposure to high concentrations of 2-(chloroethyl) ethyl sulfide (CEES), a monofunctional analog of SM, also produces severe skin lesions in mice. Utilizing a genetically engineered mouse strain, Big Blue, that allows measurement of mutation frequencies in mouse tissues, we now show that topical treatment with much lower concentrations of CEES induces significant dose- and time-dependent increases in mutation frequency in mouse skin; the mutagenic exposures produce minimal toxicity as determined by standard histopathology and immunohistochemical analysis for cytokeratin 6 and the DNA-damage induced phosphorylation of histone H2AX (?-H2AX). We attempted to develop a therapeutic that would inhibit the CEES-induced increase in mutation frequency in the skin. We observe that multi-dose, topical treatment with 2,6-dithiopurine (DTP), a known chemical scavenger of CEES, beginning 1 h post-exposure to CEES, completely abolishes the CEES-induced increase in mutation frequency. These findings suggest the possibility that DTP, previously shown to be non-toxic in mice, may be useful as a therapeutic agent in accidental or malicious human exposures to SM. -- Highlights: ? 200 mM 2-(chloroethyl) ethyl sulfide (CEES) induces mutations in mouse skin. ? This dose of CEES is not overtly toxic, as assayed by histopathology. ? 2,6-Dithiopurine (DTP), applied after CEES-treatment, abolishes CEES-mutagenesis. ? This supports the idea that sulfur mustards exhibit long biological half-lives.

Boulware, Stephen [Division of Pharmacy and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd., Austin, TX 78723 (United States)] [Division of Pharmacy and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd., Austin, TX 78723 (United States); Fields, Tammy; McIvor, Elizabeth; Powell, K. Leslie; Abel, Erika L. [Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957 (United States)] [Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957 (United States); Vasquez, Karen M. [Division of Pharmacy and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd., Austin, TX 78723 (United States)] [Division of Pharmacy and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd., Austin, TX 78723 (United States); MacLeod, Michael C., E-mail: mcmacleod@mdanderson.org [Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957 (United States)

2012-09-01T23:59:59.000Z

282

A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12  

SciTech Connect (OSTI)

Melanocytes preferentially express an mRNA species, Pmel 17, whose protein product cross-reacts with anti-tyrosinase antibodies and whose expression correlates with the melanin content. The authors have now analyzed the deduced protein structure and mapped its chromosomal location in mouse and human. The amino acid sequence deduced from the nucleotide sequence of the Pmel 17 cDNA showed that the protein is composed of 645 amino acids with a molecular weight of 68,600. The Pmel 17 protein contains a putative leader sequence and a potential membrane anchor segment, which indicates that this may be a membrane-associated protein in melanocytes. The deduced protein contains five potential N-glycosylation sites and relatively high levels of serine and threonine. Three repeats of a 26-amino acid motif appear in the middle of the molecule. The human Pmel 17 gene, designated D12S53E, maps to chromosome 12, region 12pter-q21; and the mouse homologue, designated D12S53Eh, maps to the distal region of mouse chromosome 10, a region also known to carry the coat color locus si (silver).

Kwon, B.S.; Chintamaneni, C.; Kobayashi, Y.; Kim, K.K. (Indiana Univ.-Purdue Univ., Indianapolis (United States)); Kozak, C.A. (National Inst. of Health, Bethesda, MD (United States)); Copeland, N.G.; Gilbert, D.J.; Jenkins, N. (National Cancer Inst., Frederick, MD (United States)); Barton, D.; Francke, U. (Yale Univ., New Haven, CT (United States))

1991-10-15T23:59:59.000Z

283

Metastatic Melanoma Induced Metabolic Changes in C57BL/6J Mouse Stomach Measured by 1H NMR Spectroscopy  

SciTech Connect (OSTI)

Melanoma is a malignant tumor of melanocytes with high capability of invasion and rapid metastasis to other organs. Malignant melanoma is the most common metastatic malignancy found in gastrointestinal tract (GI). To the best of our knowledge, previous studies of melanoma in gastrointestinal tract are all clinical case reports. In this work, 1H NMR-based metabolomics approach is used to investigate the metabolite profiles differences of stomach tissue extracts of metastatic B16-F10 melanoma in C57BL/6J mouse and search for specific metabolite biomarker candidates. Principal Component Analysis (PCA), an unsupervised multivariate data analysis method, is used to detect possible outliers, while Orthogonal Projection to Latent Structure (OPLS), a supervised multivariate data analysis method, is employed to evaluate important metabolites responsible for discriminating the control and the melanoma groups. Both PCA and OPLS results reveal that the melanoma group can be well separated from its control group. Among the 50 identified metabolites, it is found that the concentrations of 19 metabolites are statistically and significantly changed with the levels of O-phosphocholine and hypoxanthine down-regulated while the levels of isoleucine, leucine, valine, isobutyrate, threonine, cadaverine, alanine, glutamate, glutamine, methionine, citrate, asparagine, tryptophan, glycine, serine, uracil, and formate up-regulated in the melanoma group. These significantly changed metabolites are associated with multiple biological pathways and may be potential biomarkers for metastatic melanoma in stomach.

Wang, Xuan; Hu, Mary Y.; Liu, Maili; Hu, Jian Z.

2014-12-05T23:59:59.000Z

284

Interactions between ultraviolet light and interleukin-1 on MSH binding in both mouse melanoma and human squamous carcinoma cells  

SciTech Connect (OSTI)

Interactions between beta-melanotropin (MSH), interleukin 1-a (IL-1), and ultraviolet light (UV) were examined in Cloudman S91 mouse melanoma and RHEK human squamous carcinoma cell lines. The following points were established: (1) both cell lines produced IL-1 and their production was stimulated by exposure of the cells to UV; (2) both cell lines possessed high affinity binding sites for MSH, and their ability to bind MSH was modulated by IL-1; (3) IL-1 exhibited both stimulatory and inhibitory effects on MSH binding to Cloudman cells; and (4) the stimulatory effect of IL-1 on MSH binding to melanoma cells was reflected in enhanced cellular responsiveness to MSH regarding tyrosinase activity (E.C. 1.14.18.1) and melanin content. The findings raise the possibility that interactions between keratinocytes and melanocytes may be regulated by IL-1 and MSH, and suggest a possible mechanism for stimulation of cutaneous melanogenesis by solar radiation: enhancement of MSH receptor activity by induction of IL-1.

Birchall, N.; Orlow, S.J.; Kupper, T.; Pawelek, J. (Univ. of Auckland, (New Zealand))

1991-03-29T23:59:59.000Z

285

Radiosensitivity of mouse lip mucosa: Influence of anesthesia, carbogen, and a new high O/sub 2/ carrying perfluorochemical emulsion  

SciTech Connect (OSTI)

The effect of a new perfluorochemical emulsion based on F-66E (54%, w/v) which carries, in combination with carbogen, twice as much oxygen as Fluosol-DA 20% was tested on the radiation response of the lip mucosa of unanesthetized mice. Mice were pretreated with 0.015 ml/g of the F-66E emulsion in the presence of carbogen for 1 h prior to and during irradiation. There was a significant increase in the mortality rate following the highest radiation dose in mice given F-66E emulsion plus carbogen. The reactions of lip mucosa of mice given F-66E emulsion and/or carbogen were not significantly different from that of the control group using three end points (average score, mean peak, incidence of mucosal desquamation), but the peak mucosal reaction was delayed. The radiosensitivity of the mouse lip mucosa to Ethrane, an anesthetic gas inhaled with carbogen, was also tested. The reaction of lip mucosa in the anesthetized mice was significantly greater than that of the control group. There was also a significant increase in the mortality rate following the two highest radiation doses.

Thomas, C.; de Vathaire, F.; Lartigau, E.; Malaise, E.P.; Guichard, M.

1989-06-01T23:59:59.000Z

286

Tissue distribution of sup 14 C- and sup 3 H-labelled misonidazole in the tumor-bearing mouse  

SciTech Connect (OSTI)

The retention of labelled misonidazole (MISO) was measured in a range of normal tissues in the mouse 24 hr after the intravenous injection of ({sup 14}C)MISO (ring labelled) and ({sup 3}H)-MISO (side-arm labelled). For ({sup 14}C)MISO the 24 hr tissue retention, in order of the highest to the lowest levels (excluding pathways of excretion), was esophageal epithelium, liver, foot pad, eyelid, lung, subcutaneous lung tumor (A110), esophageal wall, uterus, eye ball, blood, salivary gland, spleen, voluntary muscle, pancreas, inguinal fat. It was assumed that the {sup 14}C represented MISO metabolite(s) bound to macromolecules. An approximately similar pattern was observed for ({sup 3}H)MISO, but a higher percentage of the injected activity per gram of tissue was retained, probably due to the presence of tritiated water in the tissues. It has generally been assumed that significant levels of MISO binding are restricted to hypoxic tissues, for example tumors, but the present results show that significant levels of binding can also occur in apparently normoxic tissues. The explanation is put forward that this binding may be due to local high levels of nitroreductase capacity.

Cobb, L.M.; Nolan, J.; Butler, S. (MRC Radiobiology Unit, Didcot, Oxon (England))

1990-02-01T23:59:59.000Z

287

Skp2 promotes adipocyte differentiation via a p27{sup Kip1}-independent mechanism in primary mouse embryonic fibroblasts  

SciTech Connect (OSTI)

Skp2, the substrate-binding subunit of an SCF ubiquitin ligase complex, is a key regulator of cell cycle progression that targets substrates for degradation by the 26S proteasome. We have now shown that ablation of Skp2 in primary mouse embryonic fibroblasts (MEFs) results both in impairment of adipocyte differentiation and in the accumulation of the cyclin-dependent kinase inhibitor p27{sup Kip1}, a principal target of the SCF{sup Skp2} complex. Genetic ablation of p27{sup Kip1} in MEFs promoted both lipid accumulation and adipocyte-specific gene expression. However, depletion of p27{sup Kip1} by adenovirus-mediated RNA interference failed to correct the impairment of adipocyte differentiation in Skp2{sup -/-} MEFs. In contrast, troglitazone, a high-affinity ligand for peroxisome proliferator-activated receptor {gamma} (PPAR{gamma}), largely restored lipid accumulation and PPAR{gamma} gene expression in Skp2{sup -/-} MEFs. Our data suggest that Skp2 plays an essential role in adipogenesis in MEFs in a manner that is at least in part independent of regulation of p27{sup Kip1} expression.

Okada, Mitsuru; Sakai, Tamon; Nakamura, Takehiro [Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Tamamori-Adachi, Mimi; Kitajima, Shigetaka [Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510 (Japan); Matsuki, Yasushi; Watanabe, Eijiro; Hiramatsu, Ryuji [Pharmacology Research Laboratories, Dainippon Sumitomo Pharma Co. Ltd., Takarazuka 665-0051 (Japan); Sakaue, Hiroshi [Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Department of Pharmacology, Kinki University School of Medicine, Osakasayama 589-8511 (Japan)], E-mail: hsakaue@med.kindai.ac.jp; Kasuga, Masato [Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017 (Japan); Research Institute, International Medical Center of Japan, Tokyo 162-8655 (Japan)

2009-02-06T23:59:59.000Z

288

Shock jump relations for multiphase mixtures with stiff mechanical relaxation  

E-Print Network [OSTI]

characteristic velocity is the sound speed, while thermal relaxation is related with diffusive effects whose mixtures, shock propagation in solid alloys, solid and liquid propellants as well as condensed solid

289

Jump, scrape, break the switches Coast low wit da bitches  

E-Print Network [OSTI]

Psylocibin, peyote Mda and dnt spells ecstasy Güero canelo Coil spring, bounce, crank Pumps, shocks Mda and dnt spells ecstasy Güero canelo Coil spring, bounce, crank Pumps, shocks, struts, tanks

Reiners, Peter W.

290

Rice Formula for processes with jumps and applications Federico Dalmao  

E-Print Network [OSTI]

Rep´ublica, Rivera 1350, 50000, Salto, Uruguay. Telephone number: 598 47334816 ext. 105. E Rep´ublica, Igu´a 4225, 11400, Montevideo, Uruguay. Telephone number: 598 2525 2522, E-mail: mordecki

291

Optimal Execution Under Jump Models For Uncertain Price Impact  

E-Print Network [OSTI]

May 12, 2011 ... Indeed price impact of large trades have been considered as one of the ... Investment performance is substantially related to the execution cost ...

2012-08-13T23:59:59.000Z

292

Side-Jump Effect in Paramagnetic Amorphous Metals  

E-Print Network [OSTI]

A systematic study of the resistivity (rho), the Hall coefficients (R(H)), and the magnetic susceptibilities (chi) of the Zr-based paramagnetic amorphous alloys suggests a self-consistent explanation for the frequently observed positive values of R...

RHIE, K.; Naugle, Donald G.; O, BH; MARKERT, JT.

1993-01-01T23:59:59.000Z

293

Optimal Execution Under Jump Models For Uncertain Price Impact  

E-Print Network [OSTI]

Aug 13, 2012 ... A major source of the execution cost comes from price impacts of both the investor's own trades and other concurrent institutional trades.

Somayeh Moazeni

2012-08-13T23:59:59.000Z

294

Eleven Tribes Jump START Clean Energy Projects, Summer 2012 (Newsletter)  

SciTech Connect (OSTI)

This newsletter describes key activities of the DOE Office of Indian Energy Policy and Programs for Summer 2012. The U.S. Department of Energy Office of Indian Energy Policy and Programs (DOE-IE) has selected 11 Tribes - five in Alaska and six in the contiguous United States - to receive on-the-ground technical support for community-based energy efficiency and renewable energy projects as part of DOE-IE's Strategic Technical Assistance Response Team (START) Program. START finalists were selected based on the clarity of their requests for technical assistance and the ability of START to successfully work with their projects or community. Technical experts from DOE and its National Renewable Energy Laboratory (NREL) will work directly with community-based project teams to analyze local energy issues and assist the Tribes in moving their projects forward. In Alaska, the effort will be bolstered by DOE-IE's partnership with the Denali Commission, which will provide additional assistance and expertise, as well as funding to fuel the Alaska START initiative.

Not Available

2012-06-01T23:59:59.000Z

295

The circular jump is a white hole G. Jannes,1  

E-Print Network [OSTI]

on the surface of the fluid (c = gh in the shallow-water gravity wave limit, with h the fluid height and g is such that vs r > c so that surface ripples can only propagate downstream--to a subcritical flow outside, where and subcritical typically refer to the value of the Froude number Fr = vs r/ gh or the related Mach num- ber M

Weeks, Eric R.

296

NUMERICAL SIMULATIONS OF KATABATIC JUMPS IN COATS LAND, ANTARCTICA  

E-Print Network [OSTI]

supercritical to subcritical flow, in a hydraulic sense, i.e., the Froude number (Fr) of the flow changes from-Layer Meteorology (2005) 114: 413­437 � Springer 2005 #12;taining coastal open water areas (polynyas) (Bromwich, this corresponds to a change from supercritical (Froude number Fr > 1) to subcritical (Fr

Renfrew, Ian

297

Hanford's Recovery Act Payments Jump Past $1 Billion  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGY TAX POLICIES7.pdfFuel Celland Contractors |DOCUMENT RELEASE FORM !andDepartment

298

DOE Provides $30 Million to Jump Start Bioenergy Research Centers |  

Broader source: Energy.gov (indexed) [DOE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of EnergyEnergyENERGYWomenthe HouseStudents2.2at MultipleorderNuclearThisProgram to spur clean,

299

Jump River Electric Coop Inc | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Office of InspectorConcentrating Solar Powerstories on climate compatibleInformationNortheastJo-CarrollJordan:Coop

300

Barbara McClintock, Jumping Genes, and Transposition  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series to someone6 M. Babzien, I. Ben-Zvi, P. Study ofJ U LYOffsets Barbara

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
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We encourage you to perform a real-time search of NLEBeta
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301

Letcher County, Kentucky: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow, Washington- A

302

Leupp, Arizona: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow, Washington- ALeupp, Arizona:

303

Levan Town Corporation (Utility Company) | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow, Washington- ALeupp,

304

Levant, Maine: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow, Washington- ALeupp,Levant,

305

Level Plains, Alabama: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow, Washington-

306

Levelland Hockley County Ethanol LLC | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow, Washington-Levelland Hockley

307

Leveraged Green Energy LCC | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow, Washington-Levelland

308

Levis, Wisconsin: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow, Washington-LevellandLevis,

309

Leviton Lighting | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,

310

Levy County, Florida: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,Levy County, Florida: Energy

311

Lewis County, Idaho: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,Levy County, Florida:

312

Lewis County, Kentucky: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,Levy County, Florida:35. It is

313

Lewis County, Missouri: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,Levy County, Florida:35. It

314

Lewis County, New York: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,Levy County, Florida:35.

315

Lewis County, New York: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,Levy County, Florida:35.Lewis

316

Lewis County, Tennessee: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,Levy County,

317

Lewis County, Washington: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,Levy County,41. It is

318

Lewis County, West Virginia: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,Levy County,41. It isLewis

319

Lewis and Clark County, Montana: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

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320

Lewisboro, New York: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,Levy County,41. ItLewisboro,

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Lewisburg, Pennsylvania: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

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322

Lexington County, South Carolina: Energy Resources | Open Energy  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,Levy County,41.Information

323

Lexington County, Virginia: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,Levy

324

Lexington Hills, California: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,LevyLexington Hills,

325

Lexington, Ohio: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,LevyLexington Hills,Lexington

326

Lexington, Oklahoma: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,LevyLexington

327

Leyden, New York: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,LevyLexingtonLeyden, New York:

328

Leyte Geothermal Area | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,LevyLexingtonLeyden, New

329

LiDAR (Laney, 2005) | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,LevyLexingtonLeyden, NewLiDAR

330

LiDAR (Lewicki & Oldenburg) | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,LevyLexingtonLeyden,

331

LiDAR (Lewicki & Oldenburg, 2004) | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to:46 - 429Lacey, Washington:Lakeville,LeightonLeola,Meadow,LevyLexingtonLeyden,Oldenburg,

332

Project Frog | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy ResourcesLoadingPenobscot County, Maine:Plug Power IncPowderClimateMeadows,Progressive LightingFrog Jump

333

Descriptors of Posidonia oceanica meadows: Use and application C. Pergent-Martini a  

E-Print Network [OSTI]

,*, V. Pasqualini a , G.D. Ardizzone b , E. Balestri c , R. Bedini d , A. Belluscio b , T. Belsher e , J

Boudouresque, Charles F.

334

Impact of cutting date on carabids and spiders in a wet meadow Denis Lafagea,b,*  

E-Print Network [OSTI]

.g. Britschgi et al., 2006) and phytophagous arthropods (e.g. Morris and Plant, 1983) has been well studied-Benítez and Méndez, 2011) or leafhoppers (Rothenbücher and Schaefer, 2006) in particular. Arthropods are however in pest control (Symondson et al., 2002). Spiders are sensitive to changes in habitat structure (Duffey

Paris-Sud XI, Université de

335

ariparian fen-meadow ecosystem: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Websites Summary: cycling Production Fire Forest Structure Forest Composition Roads Logging Insects Disease Herbivory(oC) 15 20 25 Clearcut Old growth Year Effect of removal...

336

In the Sierra Nevada of California, subalpine meadows are some of the most scenic and eco-  

E-Print Network [OSTI]

pronostican. Nuestro objetivo fue describir los patrones de biomasa de las plantas vasculares vivas sobre el nivel de la tierra y su variabilidad en relación con los facto- res climáticos. Extrajimos biomasa sobre

337

Patterns in fish assemblages and seagrass herbivory in a temperate Australian seagrass meadow.  

E-Print Network [OSTI]

??While eutrophication of coastal waters has long been attributed as a major cause of seagrass decline, there is now emerging evidence from both tropical and… (more)

White, Kirrily

2011-01-01T23:59:59.000Z

338

Fact Sheet - Purchase of woldlife habitat in Big Meadows - March 2007  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsing ZirconiaPolicy andExsolutionFES6FYRANDOM DRUG TESTING TheMay 2012 B

339

Assay using embryo aggregation chimeras for the detection of nonlethal changes in X-irradiated mouse preimplantation embryos  

SciTech Connect (OSTI)

We have developed a short-term in vitro assay for the detection of sublethal effects produced by very low levels of ionizing radiation. The assay utilizes mouse embryo aggregation chimeras consisting of one irradiated embryo paired with an unirradiated embryo whose blastomeres have been labeled with fluorescein isothiocyanate (FITC). X irradiation (from 0.05 to 2 Gy) and chimera construction were performed with four-cell stage embryos, and the chimeras were cultured for 40 h to the morula stage. The morulae were partially dissociated with calcium-free culture medium and viewed under phase contrast and epifluorescence microscopy to obtain total embryo cell number and the cellular contribution of irradiated (unlabeled) and control (FITC labeled) embryos per chimera. In chimeras where neither embryo was irradiated, the ratio of the unlabeled blastomeres to the total number of blastomeres per chimera embryo was 0.50 (17.8 +/- 5.6 cells per unlabeled embryo and 17.4 +/- 5.5 cells per FITC-labeled partner embryo). However, in chimeras formed after the unlabeled embryos were irradiated with as little as 0.05 Gy, the ratio of unlabeled blastomeres to the total number of blastomeres per chimera embryo was 0.43 (P less than 0.01). The apparent decreases in cell proliferation were not observed in irradiated embryos that were merely cocultured with control embryos, regardless of whether the embryos were zona enclosed or zona free. We conclude that very low levels of radiation induce sublethal changes in cleaving embryos that are expressed as a proliferative disadvantage within two cell cycles when irradiated embryos are in direct cell-to-cell contact with unirradiated embryos.

Obasaju, M.F.; Wiley, L.M.; Oudiz, D.J.; Miller, L.; Samuels, S.J.; Chang, R.J.; Overstreet, J.W.

1988-02-01T23:59:59.000Z

340

Manuscript Version 6. Official copy "Mouse" in Berkshire Encyclopedia of Human-Computer Interaction, W.S. Bainbridge (ed). 2004 by Berkshire Publishing Group. http://www.berkshirepublishing.com/brw/BerkProd.asp?projID=29#  

E-Print Network [OSTI]

input to computer systems is a critical and integral part of any human-computer interaction system of the entire interactive system. The most common input device ­ the computer mouse The most common input device Engelbart and his colleagues who pioneered interactive computing with their online system NLS

Zhai, Shumin

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341

Exploring the in vitro formation of trimethylarsine sulfide from dimethylthioarsinic acid in anaerobic microflora of mouse cecum using HPLC-ICP-MS and HPLC-ESI-MS  

SciTech Connect (OSTI)

Although metabolism of arsenicals to form methylated oxoarsenical species has been extensively studied, less is known about the formation of thiolated arsenical species that have recently been detected as urinary metabolites. Indeed, their presence suggests that the metabolism of ingested arsenic is more complex than previously thought. Recent reports have shown that thiolated arsenicals can be produced by the anaerobic microflora of the mouse cecum, suggesting that metabolism prior to systemic absorption may be a significant determinant of the pattern and extent of exposure to various arsenic-containing species. Here, we examined the metabolism of {sup 34}S labeled dimethylthioarsinic acid ({sup 34}S-DMTA{sup V}) by the anaerobic microflora of the mouse cecum using HPLC-ICP-MS and HPLC-ESI-MS/MS to monitor for the presence of various oxo- and thioarsenicals. The use of isotopically enriched {sup 34}S-DMTA{sup V} made it possible to differentiate among potential metabolic pathways for production of the trimethylarsine sulfide (TMAS{sup V}). Upon in vitro incubation in an assay containing anaerobic microflora of mouse cecum, {sup 34}S-DMTA{sup V} underwent several transformations. Labile {sup 34}S was exchanged with more abundant {sup 32}S to produce {sup 32}S-DMTA{sup V}, a thiol group was added to yield DMDTA{sup V}, and a methyl group was added to yield {sup 34}S-TMAS{sup V}. Because incubation of {sup 34}S-DMTA{sup V} resulted in the formation of {sup 34}S-TMAS{sup V}, the pathway for its formation must preserve the arsenic-sulfur bond. The alternative metabolic pathway postulated for formation of TMAS{sup V} from dimethylarsinic acid (DMA{sup V}) would proceed via a dimethylarsinous acid (DMA{sup III}) intermediate and would necessitate the loss of {sup 34}S label. Structural confirmation of the metabolic product was achieved using HPLC-ESI-MS/MS. The data presented support the direct methylation of DMTA{sup V} to TMAS{sup V}. Additionally, the detection of isotopically pure {sup 34}S-TMAS{sup V} raises questions about the sulfur exchange properties of TMAS{sup V} in the cecum material. Therefore, {sup 34}S-TMAS{sup V} was incubated and the exchange was monitored with respect to time. The data suggest that the As-S bond associated with TMAS{sup V} is less labile than the As-S bond associated with DMTA{sup V}.

Kubachka, Kevin M. [US EPA, ORD, NERL, Microbiological and Chemical Exposure, Assessment Research Division, Cincinnati, OH 45268 (United States); Kohan, Michael C. [US EPA, ORD, NHEERL, Environmental Carcinogenesis Division, Research Triangle Park, NC 27711 (United States); Herbin-Davis, Karen [US EPA, ORD, NHEERL, Experimental Toxicology Division, Research Triangle Park, NC 27711 (United States); Creed, John T. [US EPA, ORD, NERL, Microbiological and Chemical Exposure, Assessment Research Division, Cincinnati, OH 45268 (United States)], E-mail: creed.jack@epa.gov; Thomas, David J. [US EPA, ORD, NHEERL, Experimental Toxicology Division, Research Triangle Park, NC 27711 (United States)

2009-09-01T23:59:59.000Z

342

Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model  

SciTech Connect (OSTI)

Research highlights: {yields} Establish a human immune-mediated type 1 diabetic model in NOD-scid IL2r{gamma}{sup null} mice. {yields} Using the irradiated diabetic NOD mouse spleen mononuclear cells as trigger. {yields} The islet {beta} cells were selectively destroyed by infiltrated human T cells. {yields} The model can facilitate translational research to find a cure for type 1 diabetes. -- Abstract: Type 1 diabetes (T1D) is caused by a T cell-mediated autoimmune response that leads to the loss of insulin-producing {beta} cells. The optimal preclinical testing of promising therapies would be aided by a humanized immune-mediated T1D model. We develop this model in NOD-scid IL2r{gamma}{sup null} mice. The selective destruction of pancreatic islet {beta} cells was mediated by human T lymphocytes after an initial trigger was supplied by the injection of irradiated spleen mononuclear cells (SMC) from diabetic nonobese diabetic (NOD) mice. This resulted in severe insulitis, a marked loss of total {beta}-cell mass, and other related phenotypes of T1D. The migration of human T cells to pancreatic islets was controlled by the {beta} cell-produced highly conserved chemokine stromal cell-derived factor 1 (SDF-1) and its receptor C-X-C chemokine receptor (CXCR) 4, as demonstrated by in vivo blocking experiments using antibody to CXCR4. The specificity of humanized T cell-mediated immune responses against islet {beta} cells was generated by the local inflammatory microenvironment in pancreatic islets including human CD4{sup +} T cell infiltration and clonal expansion, and the mouse islet {beta}-cell-derived CD1d-mediated human iNKT activation. The selective destruction of mouse islet {beta} cells by a human T cell-mediated immune response in this humanized T1D model can mimic those observed in T1D patients. This model can provide a valuable tool for translational research into T1D.

Zhao, Yong, E-mail: yongzhao@uic.edu [Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 (United States)] [Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 (United States); Guo, Chengshan; Hwang, David; Lin, Brian; Dingeldein, Michael; Mihailescu, Dan; Sam, Susan; Sidhwani, Seema [Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 (United States)] [Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 (United States); Zhang, Yongkang [Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612 (United States)] [Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612 (United States); Jain, Sumit [Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 (United States)] [Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 (United States); Skidgel, Randal A. [Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612 (United States)] [Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612 (United States); Prabhakar, Bellur S. [Department of Immunology and Microbiology, University of Illinois at Chicago, Chicago, IL 60612 (United States)] [Department of Immunology and Microbiology, University of Illinois at Chicago, Chicago, IL 60612 (United States); Mazzone, Theodore [Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 (United States)] [Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612 (United States); Holterman, Mark J. [Department of Surgery, University of Illinois at Chicago, Chicago, IL 60612 (United States)] [Department of Surgery, University of Illinois at Chicago, Chicago, IL 60612 (United States)

2010-09-03T23:59:59.000Z

343

Use of a transfected and amplified Drosophila heat shock promoter construction for inducible production of toxic mouse c-myc proteins in CHO cells  

SciTech Connect (OSTI)

After transfection and selection with methotrexate, CHO cell lines were established which contained up to 2000 copies of an expression vector for c-myc protein. The vector contained the Drosophila heat shock protein 70 (hsp70) promoter fused with the coding region of the mouse c-myc gene. Incubation of cells for up to 3 hours at 43/sup 0/C resulted in at least a 100-fold induction of recombinant c-myc mRNA. When cells were shifted back to 37/sup 0/C, within 1 to 4 hours, this RNA was translated into protein to yield about 250 ..mu..g per 10/sup 9/ cells. Cells died a few hours later, suggesting that high concentrations of intracellular c-myc are cytotoxic. 47 refs., 5 figs.

Wurm, F.M.; Gwinn, K.A.; Papoulas, O.; Pallavicini, M.; Kingston, R.E.

1987-07-24T23:59:59.000Z

344

Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: Potential model for thymic education  

SciTech Connect (OSTI)

Characteristic lesions in mice hemi- or homozygous for the X-linked mutation scurfy (sf) include lymphohistiocytic proliferation in the skin and lymphoid organs, Coombs' test-positive anemia, hypergammaglobulinemia, and death by 24 days of age. The role of the thymus in the development of fatal lymphoreticular disease in the scurfy mouse was investigated. Neonatal thymectomy doubles the life span of scurfy mice, moderates the histologic lesions, and prevents anemia, despite the continued presence of high levels of serum IgG. Animals bred to be nude and scurfy (nu/nu;sf/Y) are viable, fertile, and free of scurfy lesions. Bone marrow from scurfy mice can reconstitute lethally irradiated, H-2-compatible animals but does not transmit scurfy disease. The authors conclude, from these data, that scurfy lesions are mediated by T lymphocytes that mature in an abnormal (sf) thymic environment.

Godfrey, V.L.; Rinchik, E.M.; Russell, L.B. (Oak Ridge National Lab., Oak Ridge, TN (United States)); Wilkinson, J.E. (Univ. of Tennessee, Knoxville (United States))

1991-07-01T23:59:59.000Z

345

Structure of the mouse tyrosinase-related protein-2/dopachrome tautomerase (Tyrp2/Dct) gene and sequence of two novel slaty alleles  

SciTech Connect (OSTI)

We have isolated the eight exons and 5{prime} and 3{prime} flanking regions of the mouse tyrosinase-related protein-2 (dopachrome tautomerase) gene (Tyrp2/Dct), which is mutated in slaty mice. The gene has a structure that is considerably different from those of other tyrosinase family members in both the number and the position of introns, consistent with the suggestion that the divergence of the family represents an ancient gene duplication. We also identify in the 5{prime} flanking DNA an 11-bp element, the M-box, conserved in other tyrosinase family genes. We have characterized point mutations in two slaty alleles recently identified at the Jackson Laboratory: slaty-2J (slt{sup 2J}) has a similar phenotype to the original slaty (slt) mutation, and slaty light (Slt{sup lt}), which has a more severe effect and is semidominant. We suggest that the slaty-light phenotype is a result of the failure of the enzyme to be correctly targeted to its normal location on the inner face of the melanosomal membrane. 48 refs., 4 figs., 3 tabs.

Budd, P.S.; Jackson, I.J. [Western General Hospital, Edinburgh (United Kingdom)] [Western General Hospital, Edinburgh (United Kingdom)

1995-09-01T23:59:59.000Z

346

Vegetation dynamics of a native haymeadow, a grazed meadow, and an oldfield within the San Antonio Prairie of Texas  

E-Print Network [OSTI]

successional areas. Few relict prairies areas remain since most land is under cultivation or used for livestock grazing. Secondary succession traditionally has been studied by analyzing sites of different ages with known histories of disturbance. Few studies... for intensive study. A tallgrass prairie remnant encompasses 13. 8 ha and is used for hay and limited winter grazing by cattle and occasionally sheep. It has never been cultivated. Topography of the entire remnant varies from 122. 5 to 112 m in elevation...

Hightower, Terry Paul

1987-01-01T23:59:59.000Z

347

Native Tallgrass Prairie Remnants as "Living Museums": Landscape Context, Metacommunity Dynamics, and Private Management Practices of Native Prairie Hay Meadows  

E-Print Network [OSTI]

In fragmented tallgrass prairie remnants within eastern Kansas, smaller patch area, greater isolation, and poorer matrix quality are predicted to result in (1) decreased species richness, (2) decreased site `quality,' and (3) decreased presence...

Kilroy Mollmann, Hayley A.

2010-08-27T23:59:59.000Z

348

New Colchicinoids from a Native Jordanian Meadow Saffron, Colchicum brachyphyllum: Isolation of the First Naturally Occurring Dextrorotatory  

E-Print Network [OSTI]

of their toxic nature, and in Arabian writings of the tenth century, they were recommended for use in gout

Falkinham, Joseph

349

Process-level controls on CO2 fluxes from a seasonally snow-covered subalpine meadow soil, Niwot Ridge, Colorado  

E-Print Network [OSTI]

Research, University of Colorado, Boulder, CO, USA e-mail:of Geography, University of Colorado, Boulder, CO, USA B.Sciences, University of Colorado, Boulder, CO, USA G.

2009-01-01T23:59:59.000Z

350

Case Study: Mobile Photovoltaic System at Bechler Meadows Ranger Station, Yellowstone National Park (Brochure), Federal Energy Management Program (FEMP)  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-Up fromDepartmentTie Ltd:June 20154:04-21-2014Innovative Energy Efficiency Approaches

351

Quantitative Site-specific Reactivity Profiling of S-Nitrosylation in Mouse Skeletal Muscle Using Cysteinyl Peptide Enrichment Coupled with Mass Spectrometry  

SciTech Connect (OSTI)

S-nitrosylation (SNO) is an important reversible thiol oxidation event that has been increasingly recognized for its role in cell signaling. While many proteins susceptible to S-nitrosylation have been reported, site-specific identification of physiologically relevant SNO modifications remains an analytical challenge due to the low-abundance and labile nature of the modification. Herein we present further improvement and optimization of the recently reported, resin-assisted cysteinyl peptide enrichment protocol for SNO identification and the extension of this application to mouse skeletal muscle to identify specific sites sensitive to S-nitrosylation by quantitative reactivity profiling. The results of our data indicate that the protein- and peptide-level enrichment protocols provide comparable specificity and coverage of SNO-peptide identifications. S-nitrosylation reactivity profiling was performed by quantitatively comparing the site-specific SNO modification levels in samples treated with S-nitrosoglutathione (GSNO), an NO donor, at two different physiologically relevant concentrations (i.e., 10 ?M and 100 ?M). The reactivity profiling experiments overall identified 489 SNO-modified cysteine sites from 197 proteins with the specificity of 95.2% at the unique-peptide-level based on the percentage of Cys-peptides. Among these sites, 260 sites from 135 proteins were observed with relatively high reactivity to S-nitrosylation; such SNO-sensitive sites are more likely to be physiologically relevant. Many of the SNO-sensitive proteins are preferentially localized in mitochondria, contractile fiber and actin cytoskeleton, suggesting the susceptibility of these subcellular compartments to redox regulation. Moreover, the SNO-sensitive proteins seem to be primarily involved in metabolic pathways, including TCA cycle, glycolysis/gluconeogenesis, glutathione metabolism, and fatty acid metabolism, suggesting the importance of redox regulation in muscle metabolism and insulin action.

Su, Dian; Shukla, Anil K.; Chen, Baowei; Kim, Jong Seo; Nakayasu, Ernesto S.; Qu, Yi; Aryal, Uma K.; Weitz, Karl K.; Clauss, Therese RW; Monroe, Matthew E.; Camp, David G.; Bigelow, Diana J.; Smith, Richard D.; Kulkarni, Rohit N.; Qian, Weijun

2013-04-01T23:59:59.000Z

352

Effects of prolactin on lipid biosynthesis and protein kinase C in mouse mammary gland and NB sub 2 node lymphoma cells  

SciTech Connect (OSTI)

In cultured mouse mammary gland explants derived from 12-14 day pregnant mice, prolactin (PRL) stimulates an increased rate of incorporation of ({sup 14}C)acetate and ({sup 3}H)glucose into triglycerides. The effect is significant between 4-6 hours after addition of PRL. Enzymes likely to be rate-limiting to this process include acetyl CoA carboxylase (ACC), fatty acid synthetase, acetyl CoA synthetase, and/or pyruvate dehydrogenase (PDH). It is possible that early perturbations of phospholipid (PL) metabolism may represent the initial cellular effects of PRL. Consequently the effect of PRL on the incorporation of several precursors into PLs was determined. Employing ({sup 14}C)acetate as a substrate, PRL stimulates its incorporation into phosphatidylcholine, as early as 1-2 hours, and phosphatidylinositol, phosphatidylserine and phosphatidylethanolamine by 2-4 hours. ({sup 3}H)Glycerol incorporation into triglycerides was significantly enhanced by PRL between 4-6 hours, but not into PLs until after 16 hours. Similarly, PRL did not enhance incorporation of ({sup 32}P)O{sub 4}, ({sup 3}H)choline, ({sup 3}H)inositol or ({sup 3}H)seine into PLs until 14-16 hours after addition to culture. 12-O-tetradeconyl-phorbol-13-acetate (TPA) was found to increase ({sup 3}H)uridine incorporation into RNA, and ({sup 3}H)leucine incorporation into caseins in a PRL-like manner. In addition, PRL stimulates a transient, time-dependent translocation of PKC to the particulate fraction of mammary gland explants.

Waters, S.B.

1989-01-01T23:59:59.000Z

353

Responses of the L51781Y tk/sup +//tk/sup -/ mouse lymphoma cell forward mutation assay: III. 72 coded chemicals  

SciTech Connect (OSTI)

Seventy-two chemicals were tested for their mutagenic potential in the L51781Y tk/sup +///sup -/ mouse lymphoma cell forward mutation assay, using procedures based upon those described previously. Cultures were exposed to the chemicals for 4 hr, then cultured for 2 days before planting in soft agar with or without trifluorothymidine (TFT), 3 ..mu..g/ml. The chemicals were tested at least twice. Significant responses were obtained with allyl isothiocyanate, p-benzoquinone dioxime, benzyl acetate, 2-biphenylamine HCl, bis(2-chloro-1-methylethyl)ether, cadmium chloride, chlordane, chlorobenzene, chlorobenzilate, 2-chloroethanol, chlorothalonil, cytarabine x HCl, p,p'-DDE, diazinon, 2,6-dichloro-p-phenylenediamine, N,N-diethylthiourea, diglycidylresorcinol ether, 2,4-dimethoxy aniline x HCl, disperse yellow 3, endosulfan, 1,2-epoxyhexadecane, ethyl acrylate, ethyl benzene, ethylene thiourea, F D and C yellow Number 6, furan, heptachlor, isophorone, mercuric chloride, 4,4'-methylenedianiline x 2 HCl, methyl viologen, nickel sulfate x 6H/sub 2/O, 4,4'-oxydianiline, pentachloroethane, piperonyl butoxide, propyl gallate, quinoline, rotenone, 2,4,5,6-tetrachloro-4-nitro-anisole, 1,1,1,2-tetrachloroethane, trichlorfon, 2,4,6-trichlorophenol, 2,4,5-trimethoxybenzaldehyde, 1,1,3-trimethyl-2-thiourea, 1-vinyl-3-cyclopetene dioxide, vinyl toluene, and ziram. The assay was incapable of providing a clear indication of whether some chemicals were mutagens; these benzyl alcohol, 1,4-dichlorobenzene, phenol, succinic acid-2,2-dimethyl hydrazide, and toluene.

McGregor, D.B.; Brown, A.; Cattanach, P.; Edwards, I.; McBride, D.; Riach, C.; Caspary, W.J.

1988-01-01T23:59:59.000Z

354

Examination of the effects of arsenic on glucose homeostasis in cell culture and animal studies: Development of a mouse model for arsenic-induced diabetes  

SciTech Connect (OSTI)

Previous epidemiologic studies found increased prevalences of type 2 diabetes mellitus in populations exposed to high levels of inorganic arsenic (iAs) in drinking water. Although results of epidemiologic studies in low-exposure areas or occupational settings have been inconclusive, laboratory research has shown that exposures to iAs can produce effects that are consistent with type 2 diabetes. The current paper reviews the results of laboratory studies that examined the effects of iAs on glucose metabolism and describes new experiments in which the diabetogenic effects of iAs exposure were reproduced in a mouse model. Here, weanling male C57BL/6 mice drank deionized water with or without the addition of arsenite (25 or 50 ppm As) for 8 weeks. Intraperitoneal glucose tolerance tests revealed impaired glucose tolerance in mice exposed to 50 ppm As, but not to 25 ppm As. Exposure to 25 and 50 ppm As in drinking-water resulted in proportional increases in the concentration of iAs and its metabolites in the liver and in organs targeted by type 2 diabetes, including pancreas, skeletal muscle and adipose tissue. Dimethylarsenic was the predominant form of As in the tissues of mice in both 25 and 50 ppm groups. Notably, the average concentration of total speciated arsenic in livers from mice in the 50 ppm group was comparable to the highest concentration of total arsenic reported in the livers of Bangladeshi residents who had consumed water with an order of magnitude lower level of iAs. These data suggest that mice are less susceptible than humans to the diabetogenic effects of chronic exposure to iAs due to a more efficient clearance of iAs or its metabolites from target tissues.

Paul, David S. [Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (United States); Hernandez-Zavala, Araceli [Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (United States); Walton, Felecia S. [Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (United States); Adair, Blakely M. [Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711 (United States); Dedina, Jiri; Matousek, Tomas [Academy of Sciences of the Czech Republic, Institute of Analytical Chemistry, Laboratory of Trace Element Analysis, Videnska 1083, CZ-142 20 Prague (Czech Republic); Styblo, Miroslav [Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (United States); Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (United States)], E-mail: styblo@med.unc.edu

2007-08-01T23:59:59.000Z

355

Extracellular ATP-induced nuclear Ca{sup 2+} transient is mediated by inositol 1,4,5-trisphosphate receptors in mouse pancreatic {beta}-cells  

SciTech Connect (OSTI)

Extracellular ATP (eATP) induces an intracellular Ca{sup 2+} transient by activating phospholipase C (PLC)-associated P2X4 purinergic receptors, leading to production of inositol 1,4,5-trisphosphate (IP3) and subsequent Ca{sup 2+} release from intracellular stores in mouse pancreatic {beta}-cells. Using laser scanning confocal microscopy, Ca{sup 2+} indicator fluo-4 AM, and the cell permeable nuclear indicator Hoechst 33342, we examined the properties of eATP-induced Ca{sup 2+} release in pancreatic {beta}-cell nuclei. eATP induced a higher nuclear Ca{sup 2+} transient in pancreatic {beta}-cell nuclei than in the cytosol. After pretreatment with thapsigargin (TG), an inhibitor of sarco-endoplasmic reticulum Ca{sup 2+}-ATPase (SERCA) pumps, the amplitude of eATP-induced Ca{sup 2+} transients in the nucleus was still much higher than those in the cytosol. This effect of eATP was not altered by inhibition of either the plasma membrane Ca{sup 2+}-ATPase (PMCA) or the plasma membrane Na{sup +}/Ca{sup 2+} exchanger (NCX) by LaCl{sub 3} or by replacement of Na{sup +} with N-Methyl-Glucosamine. eATP-induced nuclear Ca{sup 2+} transients were abolished by a cell-permeable IP3R inhibitor, 2-aminoethoxydiphenyl borate (2-APB), but were not blocked by the ryanodine receptor (RyR) antagonist ryanodine. Immunofluorescence studies showed that IP3Rs are expressed on the nuclear envelope of pancreatic {beta}-cells. These results indicate that eATP triggers nuclear Ca{sup 2+} transients by mobilizing a nuclear Ca{sup 2+} store via nuclear IP3Rs.

Chen, Zheng; Li, Zhengzheng; Peng, Gong; Chen, Xiaoli; Yin, Wenxuan [National Laboratory of Biomacromolecules, Institute of Biophysics of Chinese Academy of Sciences, 15 Datun Rd., Beijing 100101 (China)] [National Laboratory of Biomacromolecules, Institute of Biophysics of Chinese Academy of Sciences, 15 Datun Rd., Beijing 100101 (China); Kotlikoff, Michael I. [Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 (United States)] [Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 (United States); Yuan, Zeng-qiang, E-mail: zqyuan@sun5.ibp.ac.cn [National Laboratory of Biomacromolecules, Institute of Biophysics of Chinese Academy of Sciences, 15 Datun Rd., Beijing 100101 (China)] [National Laboratory of Biomacromolecules, Institute of Biophysics of Chinese Academy of Sciences, 15 Datun Rd., Beijing 100101 (China); Ji, Guangju, E-mail: gj28@ibp.ac.cn [National Laboratory of Biomacromolecules, Institute of Biophysics of Chinese Academy of Sciences, 15 Datun Rd., Beijing 100101 (China)] [National Laboratory of Biomacromolecules, Institute of Biophysics of Chinese Academy of Sciences, 15 Datun Rd., Beijing 100101 (China)

2009-05-01T23:59:59.000Z

356

Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide  

SciTech Connect (OSTI)

Dermal exposure to the vesicant sulfur mustard causes marked inflammation and tissue damage. Basal keratinocytes appear to be a major target of sulfur mustard. In the present studies, mechanisms mediating skin toxicity were examined using a mouse skin construct model and a full-thickness human skin equivalent (EpiDerm-FT{sup TM}). In both systems, administration of the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide (CEES, 100-1000 {mu}M) at the air surface induced mRNA and protein expression of heat shock proteins 27 and 70 (Hsp27 and Hsp70). CEES treatment also resulted in increased expression of caveolin-1, the major structural component of caveolae. Immunohistochemistry revealed that Hsp27, Hsp70 and caveolin-1 were localized in basal and suprabasal layers of the epidermis. Caveolin-1 was also detected in fibroblasts in the dermal component of the full thickness human skin equivalent. Western blot analysis of caveolar membrane fractions isolated by sucrose density centrifugation demonstrated that Hsp27 and Hsp70 were localized in caveolae. Treatment of mouse keratinocytes with filipin III or methyl-{beta}-cyclodextrin, which disrupt caveolar structure, markedly suppressed CEES-induced Hsp27 and Hsp70 mRNA and protein expression. CEES treatment is known to activate JNK and p38 MAP kinases; in mouse keratinocytes, inhibition of these enzymes suppressed CEES-induced expression of Hsp27 and Hsp70. These data suggest that MAP kinases regulate Hsp 27 and Hsp70; moreover, caveolae-mediated regulation of heat shock protein expression may be important in the pathophysiology of vesicant-induced skin toxicity.

Black, Adrienne T. [Pharmacology and Toxicology, Rutgers University, Piscataway, NJ (United States); Hayden, Patrick J. [MatTek Corporation, Ashland, MA (United States); Casillas, Robert P. [Battelle Memorial Institute, Columbus, OH (United States); Heck, Diane E. [Environmental Health, New York Medical College, Valhalla, NY (United States); Gerecke, Donald R. [Pharmacology and Toxicology, Rutgers University, Piscataway, NJ (United States); Sinko, Patrick J. [Pharmaceutics, Rutgers University, Piscataway, NJ (United States); Laskin, Debra L. [Pharmacology and Toxicology, Rutgers University, Piscataway, NJ (United States); Laskin, Jeffrey D., E-mail: jlaskin@eohsi.rutgers.edu [Environmental and Occupational Medicine, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ (United States)

2011-06-01T23:59:59.000Z

357

Private Sector | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy ResourcesLoadingPenobscot County, Maine:Plug Power IncPowderClimateMeadows, NewPrior Lake,Sector Jump to:

358

Pro Corn LLC | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy ResourcesLoadingPenobscot County, Maine:Plug Power IncPowderClimateMeadows, NewPrior Lake,Sector Jump

359

Pro Integris | Open Energy Information  

Open Energy Info (EERE)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy ResourcesLoadingPenobscot County, Maine:Plug Power IncPowderClimateMeadows, NewPrior Lake,Sector JumpPro

360

Garden illumination for the landscape architect  

E-Print Network [OSTI]

lessly over its centuries-old white'marble statuary. I saw Versail1es by aborning, cool and f'oggy, by Che high noon sun, by the fading red and yel'ow glows of evening skies, by the blue and . grey of dusk, as long shadows crept over the meadows... by nighty Its gardens, alleys, foun- tains, and statuary could be made to live, could be made to Jump and play and run with reds, embers, and yellows, or be made to idle or lie, stilled, with greens, blues, and blacks Ro, this garden of' the kings...

Watson, J. R

1947-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Monitoring Cyp2b10 mRNA expression at cessation of 2-year carcinogenesis bioassay in mouse liver provides evidence for a carcinogenic mechanism devoid of human relevance: The dalcetrapib experience  

SciTech Connect (OSTI)

Introduction: Dalcetrapib is a cholesteryl ester transfer protein (CETP) modulator in clinical assessment for cardiovascular outcome benefits. In compliance with regulatory requirements, dalcetrapib was evaluated in rodent 2-year carcinogenesis bioassays. In the mouse bioassay, male mice demonstrated increased liver weight and statistically increased incidences of hepatocellular adenoma/carcinoma. Hepatic cytochrome p450 (Cyp) 2b10 mRNA induction and increased Cyp2b10 enzyme activity signify activation of hepatic nuclear receptor constitutive androstane receptor (CAR), a widely established promoter of rodent-specific hepatic tumors. We therefore monitored hepatic Cyp2b10 mRNA and its enzyme activity in a subset of dalcetrapib-treated male mice from the bioassay. Methods: Liver samples were obtained from ? 1/3 of male mice from each dose group including vehicle-controls (mean and earliest study day of death 678 and 459 respectively). Quantitative real time PCR (qRT-PCR) was performed to determine Cyp2b10 mRNA expression and Cyp1a-, Cyp2b10- and Cyp3a-selective activities were monitored. Results: Cyp2b10 mRNA was strongly induced by dalcetrapib with an expected wide inter-individual variation (5–1421-fold). Group average fold-induction versus vehicle-controls showed a dose-related increase from 48-fold (250 mg/kg/day) to 160-fold (750 mg/kg/day), which declined slightly at 2000 mg/kg/day (97-fold). Cyp enzyme activities showed approximate doubling of total Cyp P450 content per milligram protein and a 9-fold increase in Cyp2b10-selective pentoxyresorufin O-dealkylase activity (750 mg/kg/day). Discussion: These data from hepatic Cyp2b10 monitoring are strongly suggestive of CAR activation by dalcetrapib, a mechanism devoid of relevance towards hepatocarcinogenesis in humans; results show feasibility of Cyp2b10 as a surrogate marker for this mechanism at cessation of a carcinogenesis bioassay. -- Highlights: ? Liver tumors were induced in male mice by dalcetrapib in a 2-y study (bioassay). ? Cyp2b10 induction typifies activation of nuclear receptor CAR in mouse liver. ? First report of hepatic Cyp2b10 monitoring at the end of a mouse bioassay. ? Cyp2b10 induction supports CAR activation by dalcetrapib in mouse bioassay. ? CAR activation is a mechanism of hepatic tumorigenesis of no relevance to humans.

Hoflack, J-C.; Mueller, L., E-mail: Lutz.Mueller@roche.com; Fowler, S.; Braendli-Baiocco, A.; Flint, N.; Kuhlmann, O.; Singer, T.; Roth, A.

2012-03-15T23:59:59.000Z

362

9. international mouse genome conference  

SciTech Connect (OSTI)

This conference was held November 12--16, 1995 in Ann Arbor, Michigan. The purpose of this conference was to provide a multidisciplinary forum for exchange of state-of-the-art information on genetic mapping in mice. This report contains abstracts of presentations, focusing on the following areas: mutation identification; comparative mapping; informatics and complex traits; mutagenesis; gene identification and new technology; and genetic and physical mapping.

NONE

1995-12-31T23:59:59.000Z

363

On the pointwise jump condition at the free boundary in the 1-phase ...  

E-Print Network [OSTI]

Our paper is close in scope to [We2], where the author studies the structure of the free boundary in the space variables for a.e. level of t. He does this instead by ...

2004-02-09T23:59:59.000Z

364

Jump-Starting Zero Energy Home Design and Student Careers | Department...  

Broader source: Energy.gov (indexed) [DOE]

of Minnesota team created a home design that meets the unique challenges of the state's climate -- extreme winter cold and hot, humid summers -- while minimizing energy use. |...

365

Making Things Clearer: Exaggeration, Jumping the Gun, and The Venus Syndrome  

E-Print Network [OSTI]

the paper is published we will write a summary for a broader audience. Imminence. Recently a smart young not expect sea level rise of meters or "a different planet" in 5 or 10 or 20 years. In 2005 (AGU meeting) I

Hansen, James E.

366

Species of Mycosphaerellaceae and Teratosphaeriaceae on native Myrtaceae in Uruguay: evidence of fungal host jumps  

E-Print Network [OSTI]

Species of Mycosphaerellaceae and Teratosphaeriaceae on native Myrtaceae in Uruguay: evidence Proteccion Vegetal, Facultad de Agronomia, Universidad de la Republica, Uruguay b Forestry and Agricultural Agropecuaria (INIA), Uruguay d Department of Plant Pathology, University of Minnesota, USA a r t i c l e i n f

Blanchette, Robert A.

367

The Decidability of the Existential Theory of the Poset of Recursively Enumerable Degrees with Jump Relations  

E-Print Network [OSTI]

and Slaman [HaSl] (cf. [SlWo]), Jockusch and Soare (unpublished, cf. [Lr1]), Jockusch and Slaman [Jo

Lempp, Steffen

368

Navigate MathSciNet Jump to Search or Browse Screens  

E-Print Network [OSTI]

, CRC Press Series on Discrete Mathematics and its Applications, CRC Press, Boca Raton, 1996, MR1383823 with applications, CRC Press Series on Discrete Mathematics and its Applications, CRC Press, Boca Raton, 1998, Zbl, Some computational results on a problem of Eisenstein, Th´eorie des nombres (Quebec, PQ, 1987) (J-M De

Mollin, R.A.

369

The Inverting Effect of Curvature in Winter Terrain Park Jump Takeoffs J. A. McNeil  

E-Print Network [OSTI]

Ackery, et al. [6] found evidence of an increasing incidence of traumatic brain injury and spinal cord

370

An example of a jump from chaos to integrability for magnetic geodesic flows  

E-Print Network [OSTI]

It is proved that the motion of a charge particle on a hyperbolic oriented two-dimensional surface in a magnetic field given by the volume form of the hyperbolic metric is completely integrable on the energy levels E 1/2 are Anosov flows

I. A. Taimanov

2005-03-01T23:59:59.000Z

371

An Econometric Model of the Yield Curve With Macroeconomic Jump Effects  

E-Print Network [OSTI]

Kenneth Singleton (1997). “An Econometric Model of the TermDiscretely-Sampled Data. ” Econometric Theory 4, pp. 231-An Econometric Model of the Yield Curve with Macroeconomic

Piazzesi, Monika

2001-01-01T23:59:59.000Z

372

Depletion, quantum jumps, and temperature measurements of ??Sr? ions in a linear Paul Trap  

E-Print Network [OSTI]

This thesis describes the design and construction of two laser systems to probe the 674nm transition of ??Sr? ions in a linear Paul trap. The first laser system made use of a molecular transition in Iodine to stabilize the ...

Richerme, Philip J

2006-01-01T23:59:59.000Z

373

Multi-factor jump-diffusion models of electricity Thilo MEYER-BRANDIS  

E-Print Network [OSTI]

features of electricity prices with a particular attention to the European energy ex- changes and develop a statistical procedure for estimat- ing the sum-OU model from data. Key Words: electricity prices is therefore necessary for energy risk management, pricing of electricity-related options and evaluation

374

CUNY Unit Project Name Baruch Jump-starting Veterans' Career Success  

E-Print Network [OSTI]

in Leadership in Transportation Industry SPS HIM York Onsite RN-BSN Program at North Shore LIJ Forest Hills Page

Rosen, Jay

375

NOAAINMFS Developments U.S. Commercial Fish Landings Jump in 1976  

E-Print Network [OSTI]

increase in food fish catches and to generally rising prices. The Commerce Department agency says for processing into meal and oil also appear 10 be above the 1975 levels. Increased production of Atlan- Scientists will collect and analyze histori- cal information on harvesting, fishing ef- fort, and natural

376

A Semi-Lagrangian Approach For American Asian Options Under Jump Diffusion  

E-Print Network [OSTI]

. Finally, companies are often more interested in the average price of oil or foreign exchange rate, than companies are certainly more interested in buying oil based on its average price instead of its spot price to price continuously observed fixed strike Asian options. At each timestep a set of one dimensional

Forsyth, Peter A.

377

A SEMI-LAGRANGIAN APPROACH FOR AMERICAN ASIAN OPTIONS UNDER JUMP DIFFUSION  

E-Print Network [OSTI]

oil based on its average price instead of its spot price. For a historical review of Asian options we.A. FORSYTH, AND G. LABAHN§ Abstract. A semi-Lagrangian method is presented to price continuously observed a payoff that depends on the average price of the underlying asset over a speci£ed period of time (12

Labahn, George

378

Electrostatic charging of jumping droplets on superhydrophobic nanostructured surfaces : fundamental study and applications  

E-Print Network [OSTI]

Condensation is a ubiquitous process often observed in nature and harnessed in many industrial processes such as power generation, desalination, thermal management, and building environmental control. Recent advancements ...

Preston, Daniel J. (Daniel John)

2014-01-01T23:59:59.000Z

379

Educated and Equipped: Jump-Start Your Career in the Bioenergy Industry |  

Energy Savers [EERE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion |Energy UsageAUDITVehiclesTanklessDOJ TitleDr. Steven Chu AboutAboutDepartmentDepartment of

380

Jump-Starting Zero Energy Home Design and Student Careers | Department of  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) " ,"ClickPipelinesProvedDecemberInitiatives Initiatives Through aEnergyLowJoel B.JonathanEnergy

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Hanford's Recovery Act Payments Jump Past $1 Billion | Department of Energy  

Office of Environmental Management (EM)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "of Energy Power.pdf11-161-LNG | Department ofHTS Cable Projects HTS CableMay 2009Hanford's Recovery Act

382

Absorption in quantum electrodynamics cavities in terms of a quantum jump operator  

E-Print Network [OSTI]

We describe the absorption by the walls of a quantum electrodynamics cavity as a process during which the elementary excitations (photons) of an internal mode of the cavity exit by tunneling through the cavity walls. We estimate by classical methods the survival time of a photon inside the cavity and the quality factor of its mirrors.

V. Debierre; G. Demésy; T. Durt; A. Nicolet; B. Vial; F. Zolla

2014-03-17T23:59:59.000Z

383

Navigate MathSciNet Jump to Search or Browse Screens  

E-Print Network [OSTI]

, 455­467. 58F11 (58F18) References: 0 Reference Citations: 1 Review Citations: 0 For a C1+ -action (0

Hurder, Steven

384

In vitro cytotoxicity tests of ZnO?Bi{sub 2}O{sub 3}?Mn{sub 2}O{sub 3}-based varistor fabricated from ZnO micro and nanoparticle powders on L929 mouse cells  

SciTech Connect (OSTI)

The present study investigated the cytotoxicity of ZnO?Bi{sub 2}O{sub 3}?Mn{sub 2}O{sub 3}-varistors. To this effect, ZnO?Bi{sub 2}O{sub 3}?Mn{sub 2}O{sub 3} varistors fabricated from ZnO micro-and nanoparticle powders are prepared via conventional ceramic processing method. The effects of ZnO particle size on the properties of ZnO varistors are also investigated. The strong solid-state reaction during sintering may be attributed to the high surface area of the 20 nm ZnO nanoparticles that promote strong surface reaction. The intensity of XRD peaks reflected the high degree of crystallinity of the ZnO nanoparticles. However, the width of the peaks in case of ZnO nanoparticles has increased due to the quantum size effect. The cytotoxicity evaluation of ZnO varistor was conducted on mouse connective tissue fibroblast cells (L929) using Trypan Blue Exclusion Assay analysis. The results show that the four types of varistor samples lead to cellular mitochondrial dysfunction, morphological modifications and apoptosis at the various concentration range and the toxic effects are obviously displayed in high concentration samples. 20nm-VDR is the most toxic materials followed by 40nm-VDR, P8-VDR, and W4-VDR in a descending order.

Sendi, Rabab Khalid, E-mail: last-name3@hotmail.com, E-mail: shahromx@hotmail.com, E-mail: ameerah7@hotmail.com; Mahmud, Shahrom, E-mail: last-name3@hotmail.com, E-mail: shahromx@hotmail.com, E-mail: ameerah7@hotmail.com; Munshi, Ayman, E-mail: last-name3@hotmail.com, E-mail: shahromx@hotmail.com, E-mail: ameerah7@hotmail.com [Nano-optoelectronics Research and Technology Laboratory (N.O.R.), School of Physics, Universiti Sains Malaysia, 11800, Penang (Malaysia); Seeni, Azman, E-mail: azanseeni@gmail.com [Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, 13200, Bertam, Pulau Pinang (Malaysia)

2014-10-24T23:59:59.000Z

385

w. L. Minckley and James E. Deacon, eds. Battle Against Extinction: Native Fish Management in the American West  

E-Print Network [OSTI]

other place in the continental United States (Beatley 1971, 1977; Schwartz 1984). Ash Meadows is named

Pedersen, Scott C.

386

2,3,7,8-Tetrachlorodibenzo-p-dioxin causes increases in expression of c-erb-A and levels of protein-tyrosine kinases in selected tissues of responsive mouse strains  

SciTech Connect (OSTI)

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) administered in vivo causes drastic reduction in the weight of the mouse thymus at low doses the reduction becoming statistically significant after 2 days. To understand the cause for such thymic involution TCDD-evoked changes in various biochemical parameters in this tissue were examined. The most noticeable change was observed in the increased activity of specific protein-tyrosine kinases and protein kinase C and an increased level of p21{sup ras}-associated binding of ({sup 3}H)GTP. The above changes appear to be a selective effect on these special classes of proteins. It has become apparent that the rise in protein-tyrosine kinase activities becomes significant within 24 hr, whereas the rise in protein kinase C does not become significant until 48 hr. In view of similarities between TCDD and thyroid hormones in causing thymic involution, the levels of c-erb-A expression were assessed in the liver by using avian {sup 32}P-labeled v-erb-A probe and RNA transfer blot hybridization technique. The results clearly indicate that TCDD has the property to elevate levels of mRNA bearing homology to v-erb-A. Based on such observations a hypothesis has been proposed that TCDD owes its potency to its ability to stimulate the expression of one of a family of DNAs bearing homology to v-erb-A and that one of the major consequences of such an action is stimulation of various tyrosine kinases.

Bombick, D.W.; Jankun, J.; Tullis, K.; Matsumura, F. (Michigan State Univ., East Lansing (USA))

1988-06-01T23:59:59.000Z

387

Assignment of the tyrosinase-related protein-2 gene (TYRP2) to human chromosome 13q31-q32 by fluorescence in situ hybridization: Extended synteny with mouse chromosome 14  

SciTech Connect (OSTI)

A recombinant human genomic liver DNA [lambda]-phage library was screened with the insert of the pHuTRP-2 cDNA clone to isolate a series of bacteriophage with inserts spanning the human TYRP2 gene. One of the [lambda]-phage clones ([lambda]HuT-YRP2-7) containing a 2-kb HindIII fragment with the 5[prime] exon sequence of the cDNA as determined by sequence analysis was used for the gene localization study. DNA prepared from the phage by Qiagen chromatography was nick-translated with biotin-14-dATP and hybridized in situ at a final concentration of 5 ng/[mu]l to metaphases from two normal males. The fluorescence in situ hybridization method was modified from that previously described in that chromosomes were stained before analysis with both propidium iodide as counterstain and DAPI for chromosome identification. Twenty metaphases from the first normal male were examined for fluorescent signal. All of these metaphases showed signal on one or both chromatids of chromosome 13 in the region 13q31-q33; 88% of this signal was at the interface of bands 13q31-q32. There was a total of four nonspecific background dots observed in these 20 metaphases. A similar result was obtained from hybridization of the probe to 20 metaphases from the second normal male (data not shown). This region has also been shown to contain the propionyl coenzyme A carboxylase [alpha]-chain gene by in situ hybridization. The localization of the TYRP2 locus to human chromosome 13q31-q32 extends the syntenic region of chromosome 13 with mouse chromosome 14. 15 refs., 1 fig.

Sturm, R.A. (Univ. of Queensland, Brisbane (Australia)); Baker, E.; Sutherland, G.R. (Centre for Medical Genetics, North Adelaide (Australia))

1994-05-01T23:59:59.000Z

388

Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver  

SciTech Connect (OSTI)

The constitutive androstane receptor (CAR) regulates transcription of phenobarbital-inducible genes that encode xenobiotic-metabolizing enzymes in liver. CAR is localized to the hepatocyte cytoplasm but to be functional, it translocates into the nucleus in the presence of phenobarbital-like CAR ligands. We now demonstrate that adenovirally driven EGFP-CAR, as expected, translocates into the nucleus of normal wild-type hepatocytes following phenobarbital treatment under both in vivo and in vitro conditions. Using this approach we investigated the role of transcription coactivators PBP and PRIP in the translocation of EGFP-CAR into the nucleus of PBP and PRIP liver conditional null mouse hepatocytes. We show that coactivator PBP is essential for nuclear translocation of CAR but not PRIP. Adenoviral expression of both PBP and EGFP-CAR restored phenobarbital-mediated nuclear translocation of exogenously expressed CAR in PBP null livers in vivo and in PBP null primary hepatocytes in vitro. CAR translocation into the nucleus of PRIP null livers resulted in the induction of CAR target genes such as CYP2B10, necessary for the conversion of acetaminophen to its hepatotoxic intermediate metabolite, N-acetyl-p-benzoquinone imine. As a consequence, PRIP-deficiency in liver did not protect from acetaminophen-induced hepatic necrosis, unlike that exerted by PBP deficiency. These results establish that transcription coactivator PBP plays a pivotal role in nuclear localization of CAR, that it is likely that PBP either enhances nuclear import or nuclear retention of CAR in hepatocytes, and that PRIP is redundant for CAR function.

Guo Dongsheng [Department of Pathology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611 (United States); Sarkar, Joy [Department of Pathology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611 (United States); Ahmed, Mohamed R. [Department of Pathology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611 (United States); Viswakarma, Navin [Department of Pathology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611 (United States); Jia Yuzhi [Department of Pathology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611 (United States); Yu Songtao [Department of Pathology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611 (United States); Sambasiva Rao, M. [Department of Pathology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611 (United States); Reddy, Janardan K. [Department of Pathology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611 (United States)]. E-mail: jkreddy@northwestern.edu

2006-08-25T23:59:59.000Z

389

Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/?-catenin signaling pathway  

SciTech Connect (OSTI)

Exposure to carcinogenic metals, such as trivalent arsenic [As(III)] and hexavalent chromium [Cr(VI)], through drinking water is a major global public health problem and is associated with various cancers. However, the mechanism of their carcinogenicity remains unclear. In this study, we used azoxymethane/dextran sodium sulfate (AOM/DSS)-induced mouse colitis-associated colorectal cancer model to investigate their tumorigenesis. Our results demonstrate that exposure to As(III) or Cr(VI), alone or in combination, together with AOM/DSS pretreatment has a promotion effect, increasing the colorectal tumor incidence, multiplicity, size, and grade, as well as cell inflammatory response. Two-dimensional differential gel electrophoresis coupled with mass spectrometry revealed that As(III) or Cr(VI) treatment alone significantly changed the density of proteins. The expression of ?-catenin and phospho-GSK was increased by treatment of carcinogenic metals alone. Concomitantly, the expression of NADPH oxidase1 (NOX1) and the level of 8-OHdG were also increased by treatment of carcinogenic metals alone. Antioxidant enzymes, such as superoxide dismutase (SOD) and catalase, were decreased. Similarly, in an in vitro system, exposure of CRL-1807 to carcinogenic metals increased reactive oxygen species (ROS) generation, the expression of ?-catenin, phospho-GSK, and NOX1. Inhibition of ROS generation by addition of SOD or catalase inhibited ?-catenin expression and activity. Our study provides a new animal model to study the carcinogenicity of As(III) and Cr(VI) and suggests that As(III) and Cr(VI) promote colorectal cancer tumorigenesis, at least partly, through ROS-mediated Wnt/?-catenin signaling pathway. -- Highlights: ? Carcinogenic metals in drinking water promote colorectal tumor formation in vivo. ? Carcinogenic metals induce ?-catenin activation in vivo and in vitro. ? ROS generation induced by carcinogenic metals mediated ?-catenin activation.

Wang, Xin; Mandal, Ardhendu K. [Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536 (United States)] [Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536 (United States); Saito, Hiroshi [Department of Surgery and Physiology, Lucille P. Markey Cancer Center, University of Kentucky, Lexington, KY 40536 (United States)] [Department of Surgery and Physiology, Lucille P. Markey Cancer Center, University of Kentucky, Lexington, KY 40536 (United States); Pulliam, Joseph F.; Lee, Eun Y. [Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY 40536 (United States)] [Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY 40536 (United States); Ke, Zun-Ji; Lu, Jian; Ding, Songze [Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536 (United States)] [Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536 (United States); Li, Li [Department of Family Medicine, Case Western Reserve University, Cleveland, OH 44106 (United States)] [Department of Family Medicine, Case Western Reserve University, Cleveland, OH 44106 (United States); Shelton, Brent J.; Tucker, Thomas [Markey Cancer Control Program, University of Kentucky, Lexington, KY 40504 (United States)] [Markey Cancer Control Program, University of Kentucky, Lexington, KY 40504 (United States); Evers, B. Mark [Department of Surgery and Physiology, Lucille P. Markey Cancer Center, University of Kentucky, Lexington, KY 40536 (United States)] [Department of Surgery and Physiology, Lucille P. Markey Cancer Center, University of Kentucky, Lexington, KY 40536 (United States); Zhang, Zhuo [Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536 (United States)] [Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536 (United States); Shi, Xianglin, E-mail: xshi5@uky.edu [Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536 (United States)] [Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536 (United States)

2012-07-01T23:59:59.000Z

390

PRE-MATING COMMUNICATION AND HYBRIDIZATION BETWEEN TWO MEADOW KATYDIDS, ORCHELIMUM NIGRIPES AND O. PULCHELLUM (ORTHOPTERA: TETTIGONIIDAE): MALE CALLING SONG AND ASYMMETRIC FEMALE PREFERENCE  

E-Print Network [OSTI]

, males of both parental species and the hybrids would sing from lower grassy vegetation as well as high in kudzu and trees. They were also observed feeding on seeds and insect prey (which were ubiquitous), so this hybrid zone is not likely an ecotonal...

Miller, Ginger

2010-12-06T23:59:59.000Z

391

Winter and summer nitrous oxide and nitrogen oxides fluxes from a seasonally snow-covered subalpine meadow at Niwot Ridge, Colorado  

E-Print Network [OSTI]

of Geography, University of Colorado, Boulder, CO, USA M. W.Alpine Research, University of Colorado, Boulder, CO, USA D.Sciences, University of Colorado, Boulder, CO, USA B. Hall

2009-01-01T23:59:59.000Z

392

Mysteries around the graph Laplacian eigenvalue 4 Yuji Nakatsukasa1  

E-Print Network [OSTI]

from the eigen- value 0 up to 4. Then, at the eigenvalue 4, there is a sudden jump as shown in Figure 1 Laplacian eigen- value distributions. (a) 2D projection of dendrites of an RGC of a mouse; (b to the eigenvalues below 4 are semi-global oscillations (like Fourier modes) over the entire tree or one

Saito, Naoki

393

Gamma irradiation of the prenatal mouse dentition  

E-Print Network [OSTI]

as the dental lamina to the stage of the deposition of enamel and dentin. The purpose of this study was to determine the effect of a continuous stress of gamma irradiation on the structure of the odontogenic cells, the relative size and rate of development... development. In 1927, Leist (9) made a study of the effect of X-rays on teeth, which was brought about by the following rase. A worker in a Roentgen tube factory was exposed daily to a considerable dose of X-irradiation. Sometime later he began to show...

Kerley, Michael Auston

1969-01-01T23:59:59.000Z

394

Characterization of individual mouse cerebrospinal fluid proteomes...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

128 proteins from three individual CSF samples that have been previously identified in brain tissue. Our methods and analysis provide a mechanism for individual murine CSF...

395

Detection of nanosecond time scale side-chain jumps in a protein dissolved in water/glycerol solvent  

E-Print Network [OSTI]

a positive identification of nanosecond dynamics in Val-23 where ns motions were already observed earlier. In several other cases, however, only tentative identification was possible. The lack of definitive results. In particular, it has been found that the overall protein tumbling is controlled by the bulk solvent

Skrynnikov, Nikolai

396

Biomechanical and Neuromuscular Changes in Jump Landings Due to Short or Long Term Ankle Bracing and Fatigue.  

E-Print Network [OSTI]

??In order to prevent ankle sprain, prophylactic ankle bracing is common practice for many sports. The purpose of this dissertation was to investigate changes in… (more)

Stafford, Elizabeth Decatur

2012-01-01T23:59:59.000Z

397

Quantifying Relationships Between Bird And Butterfly Community Shifts And Environmental Change.  

E-Print Network [OSTI]

in remotely sensed data with analyses of bird and butterfly community changes in montane meadow communities of the Greater Yellowstone Ecosystem. Landsat satellite imagery was used to classify these meadows into six types along a hydrological gradient...

Debinski, Diane M.; VanNimwegen, Ron E.; Jakubauskas, Mark E.

2006-01-01T23:59:59.000Z

398

Fact Sheet Fact Sheet Fact Sheet B O N N E V I L L E P O W E  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Red River Meadow conservation easement will protect fish, elk habitat In the heart of the Nez Perce National Forest in north central Idaho, prime meadow habitat serves as early...

399

Campus Planning Committee February 26, 2013 2:00-4:00 p.m.  

E-Print Network [OSTI]

guestrooms for convenient and affordable accommodation for out-of-town visitors. C. TPL Gift ­ Ocean Meadows

California at Santa Barbara, University of

400

Free to Explore a Museum : : Embodied Inquiry and Multimodal Expression of Meaning  

E-Print Network [OSTI]

U.K. :  Blackwell.   Balcomb,  F. ,  Newcombe,  N.S. ,  Goldin-­?Meadow,  2011;  Balcomb,  Newcombe,  Ferrara,  

Renner, Nancy Owens

2013-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

17. Saleska, S. R., Harte, J. & Torn, M. S. The effect of experimental ecosystem warming on CO2 uxes in a montane meadow. Glob. Change Biol. 5, 125141 (1999).  

E-Print Network [OSTI]

. National Cooperative Soil Survey 1±151 (US Department of Agriculture, Soil Survey of McClain County of ®fteen sites in the tall-grass prairie of Oklahoma. Proc. Oklahoma Acad. Sci. 60, 39±42 (1980). 27, Oklahoma Agricultural Experiment Station, Stillwater, 1963). 28. Shaver, G. R. et al. Global warming

Sullivan, Jack

402

I N T R O D U C T I O N Serendipity is jumping into a haystack to search for a needle, and  

E-Print Network [OSTI]

for coincident gamma-ray detections in multiple satellites. One event, from July 2, 1967, stood out (figure 1-rays, gamma rays (sometimes written as -rays), and neutrons that are produced in copious numbers in the first's atmosphere essentially blocks X-rays, gamma rays, and neutrons from space. While the signatures of nuclear

Landweber, Laura

403

A model study of the effect of bucket dentations on a ski-jump spillway jet: with a mathematical analysis of critical bucket radius determination.  

E-Print Network [OSTI]

investigations have not shown this high a degree of success, however, the reduction is con- siderable in most cases. 10 The problem of cavitation must be dealt with any time there is an abrupt change of direction of flow of a high speed stream. lnas- rnuch... as rounding of sharp corners has a tendency to reduce cavita- tion it can be seen that dentations with rounded crowns have a dual advantage. The problem of cavitation will not become evident in the normal spillway model tests. Relative Velocit of Jet...

Gladwell, John Stuart

1961-01-01T23:59:59.000Z

404

Eleven Tribes Jump START Clean Energy Projects, Summer 2012 (Newsletter), U.S. Department of Energy (DOE) Office of Indian Energy (OIE), Indian Energy Beat  

Broader source: Energy.gov (indexed) [DOE]

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary) "ofEarly Career Scientists'Montana.Program - LibbyofThisStatementNOTElectricity

405

Observations on feeding behavior in the vesper mouse, Nyctomys sumichrasti  

E-Print Network [OSTI]

47C119C119C119C46C117C114C98C97C110C102C105C115C99C104C101C114C46C100C101C47C106C111C117C114C110C97C108C115C47C109C97C109C109C98C105C111C108 C90C101C105C116C115C99C104C114C105C102C116 C102C117C200C114C83C97C200C117C103C101C116C105C101C114C107C117C110C... C97C115C44 C76C97C119C114C101C110C99C101C44 C75C97C110C115C97C115C59C68C101C112C97C114C116C109C101C110C116 C111C102C70C111C114C101C115C116C114C121C44C77C105C99C104C105C103C97C110C83C116C97C116C101 C85C110C105C118C101C114C115C105C116C121C44C69C97C115C...

Timm, Robert M.; Vriesendorp, Corine

2003-04-01T23:59:59.000Z

406

a13 control mouse: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

One of the first indications that mitochondria may play a role in pathogenesis was the report nearly Douglas C. Wallace 1999-01-01 117 Research and Development of a 13-inch...

407

Mammalian genetics pioneer Liane Russell writes Mouse House history...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ResearchReviews in Mutation Research is publicly available at http:www.sciencedirect.comsciencearticlepiiS1383574213000690 . - Bill Cabage, 865.574.4399, December 30...

408

Glove Mouse Project The goal of this project  

E-Print Network [OSTI]

that is cost-effective,easy to use, and portable. Hybrid, High-performance Cluster Computer Setup The objective it to create a viable fuel for use in a diesel engine. Multi-Functional Automated Turret Stand alone turret Design and implementation of an unmanned aerial vehicle which is capable of autonomous control via

de Lijser, Peter

409

The proteome of mouse brain microvessel membranes and basal lamina  

E-Print Network [OSTI]

IPI00849927 IPI00113377 Gene Vim Mbp Lrp1 Gnaq Ahnak AlcamIPI00319830.7 IPI00115564.5 Aco2 Vim Tubb3 Ncam1 Gnao1 Mdh2

Chun, Hyun Bae

2011-01-01T23:59:59.000Z

410

Metabonomic Profiling of TASTPM Transgenic Alzheimer's Disease Mouse Model  

SciTech Connect (OSTI)

Identification of molecular mechanisms underlying early stage Alzheimer’s disease (AD) is important for the development of new therapies against and diagnosis of AD. In this study, non-targeted metabotyping of TASTPM transgenic AD mice was performed. The metabolic profiles of both brain and plasma of TASTPM mice were characterized using gas chromatography-mass spectrometry and compared to those of wild type C57BL/6J mice. TASTPM mice were metabolically distinct compared to wild type mice (Q28 Y = 0.587 and 0.766 for PLS-DA models derived from brain and plasma, respectively). A number of metabolites were found to be perturbed in TASTPM mice in both brain (D11 fructose, L-valine, L-serine, L-threonine, zymosterol) and plasma (D-glucose, D12 galactose, linoleic acid, arachidonic acid, palmitic acid and D-gluconic acid). In addition, enzyme immunoassay confirmed that selected endogenous steroids were significantly perturbed in brain (androstenedione and 17-OH-progesterone) and plasma (cortisol and testosterone) of TASTPM mice. Ingenuity pathway analysis revealed that perturbations related to amino acid metabolism (brain), steroid biosynthesis (brain), linoleic acid metabolism (plasma) and energy metabolism (plasma) accounted for the differentiation of TASTPM and wild-type

Hu, Zeping; Browne, Edward R.; Liu, Tao; Angel, Thomas E.; Ho, Paul C.; Chun Yong Chan, Eric

2012-12-07T23:59:59.000Z

411

Characterization of Neuropeptide Y Expressing Cells in the Mouse Retina  

E-Print Network [OSTI]

present in two layers, the inner nuclear layer (INL) and the ganglion cell layer (GCL). The cells in both layers were densely distributed, with those in the INL having a mean density of 1452 65 cells/mm2 , and those in the GCL having a mean density of 644 41 cells/mm2 . The cells in the INL extended

Nirenberg, Sheila

412

Laminar circuit organization and response modulation in mouse visual cortex  

E-Print Network [OSTI]

1.25 NaH2PO4, 4 MgCl2, 0.5 CaCl2, and 24 NaHCO3). SlicesNaCl, 2.5 KCl, 26 NaHCO3, 2 CaCl2, 2 MgCl2, 1.25 NaH2PO4,

Olivas, Nicholas D; Quintanar-Zilinskas, Victor; Nenadic, Zoran; Xu, Xiangmin

2012-01-01T23:59:59.000Z

413

aux tissus mous: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: Cette note presente un moniteur d'acces aux donnees d'un PLC Schneider ou Siemens, pouvant fonctionner sur n'importe quelle plateforme (Windows, Linux...) equipee...

414

Conservation of exon scrambling in human and mouse  

E-Print Network [OSTI]

Exon scrambling is a phenomenon in which the exons of an mRNA transcript are spliced in an order inconsistent with that of the genome. In this thesis, I present a computational analysis of scrambled exons in human and ...

Hamilton, Monica L. (Monica Lauren)

2012-01-01T23:59:59.000Z

415

RAPID/Best Practices/Memorandums of Understanding (MOUs) for...  

Open Energy Info (EERE)

In some cases, the development of an MOU (particularly negotiation of the MOU terms) has been viewed as a distraction that prevented the project from move forward in a...

416

The development of direction selectivity in the mouse retina  

E-Print Network [OSTI]

firing of starburst amacrine cells and DSGCs, is not necessary to establish the retinal circuitsfiring rate in the null direction is as low as in adult, indicating that the circuits

Elstrott, Justin Blake

2009-01-01T23:59:59.000Z

417

Increased Levels of Inosine in a Mouse Model of Inflammation  

E-Print Network [OSTI]

One possible mechanism linking inflammation with cancer involves the generation of reactive oxygen, nitrogen, and halogen species by activated macrophages and neutrophils infiltrating sites of infection or tissue damage, ...

Prestwich, Erin

418

Comparative analysis of proteome and transcriptome variation in mouse  

E-Print Network [OSTI]

Ghazalpour 1 * . , Brian Bennett 1. , Vladislav A. PetyukNat Genet 41: 166–167. 12. Bennett BJ, Farber CR, Orozco L,Citation: Ghazalpour A, Bennett B, Petyuk VA, Orozco L,

2011-01-01T23:59:59.000Z

419

Effects of Systemic Inflammation on Synaptogenesis in Developing Mouse Hippocampus  

E-Print Network [OSTI]

2(3):284-291. Streit WJ, Graeber MB, Kreutzberg GW. 1988.2(3):284-291. Streit WJ, Graeber MB, Kreutzberg GW. 1988.

Sloniowski, Slawomir

2011-01-01T23:59:59.000Z

420

Acquisition and Mining of the Whole Mouse Brain Microstructure  

E-Print Network [OSTI]

joined the Brain Networks Laboratory (BNL) and his patient and thoughtful advice led me to the point where I am now. I particularly want to thank him for letting me join the laboratory and have this wonderful opportunity. Dr. Ricardo Gutierrez-Osuna has... the pleasure of working. Finally, I would like to thank the late Dr. Bruce H. McCormick whose vision and unstoppable drive for research have been greatly in uential to me. All achievements in BNL would not have been possible without his dream. He...

Kwon, Jae-Rock

2010-10-12T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Interferon-Stimulated Genes in the Pregnant Mouse Uterus  

E-Print Network [OSTI]

on for eac h respe ctive g ene. L E, luminal e pithel ium; G E, glan dula r e pitheli um; D ,d eci du a. D D D D LE LE LE GE D LE 18 FIG. 4. ISH analysis of Isg1 5, Nm i, O as2 , a nd Plsc r1 in e ndom etria an d con ceptuse... GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994, 264(5164):1415- 1421. 27. Ritchie KJ, Hahn CS, Kim KI, Yan M, Rosario D, Li L, de la Torre JC, Zhang DE: Role of ISG...

Tilford, Sarah

2008-08-24T23:59:59.000Z

422

PRIME R NOTES Microsatellite markers in wood mouse  

E-Print Network [OSTI]

, USA Keywords: Apodemus, Chelyabinsk, genetic markers, microsatellites, Murinae Received 13 June 1997 in the vicinity of Chelyabinsk, Russia, one of the Earth's most radioactively and chemically polluted spots. Here of the microsatellite markers is described in animals collected near Chelyabinsk. Mice of the genus Apodemus comprise

Baker, Robert J.

423

antigen mouse monoclonal: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in adulthood of autoreactive T cells specific to that antigen. The renal-specific ... Marshall, Naomi Jane 2009-01-01 45 The Journal of Neuroscience, March 1988, 8(3): 874-882...

424

attenuates mouse neuroinvasiveness: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Kowar; Otmar Scherzer 2010-09-22 7 Atlas-based attenuation correction for small animal PETMRI scanners Abhijit J. Chaudhari, ajchaudhari@ucdavis.edu, Biology and Medicine...

425

Changes in misonidazole binding with hypoxic fraction in mouse tumors  

SciTech Connect (OSTI)

Binding of misonidazole (MISO) or a derivative to hypoxic cells in tumors has been proposed as a method for identifying tumors, and measuring their level of hypoxia. The author has recently shown that the hypoxic fraction of tumor cells can be altered over a wide range in vivo by acutely changing the hematocrit of the host animal by transfusion. The present study is aimed to investigate the changes in binding by /sup 14/C MISO that accompanied this procedure. Tumor bearing mice were injected with /sup 14/C MISO, irradiated with a single dose of X rays (20 Gy) and their tumor excised and bisected. One half of each tumor was used to determine cell survival in vitro, the other was used for /sup 14/C scintillation counting. As previously described, tumor cell survival was dramatically increased in acutely anemic mice and this was accompanied by an increase in /sup 14/C MISO binding to the tumors. The relationship between clonogenic cell survival and binding was found to be linear on a log-log plot for each of the tumor lines studied, but the slopes of the lines were different in different tumor lines and generally steeper than the value of 1.0 expected for a 1:1 correspondence between cells binding radioactivity and radiobiological resistance.

Hirst, D.G.; Hazlehurst, J.L.; Brown, J.M.

1985-07-01T23:59:59.000Z

426

Transgenic mouse models of childhood-onset psychiatric disorders  

E-Print Network [OSTI]

Childhood-onset psychiatric disorders, such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), mood disorders, obsessive compulsive spectrum disorders (OCSD), and schizophrenia (SZ), affect ...

Robertson, Holly Rochelle

427

Expression of esterase-2 in developing mouse embryos and neonates  

E-Print Network [OSTI]

as maternal invironments in which the gene product can be assayed. The esterase-2 gene product (ES-2) was purified by means of isoelectric foc- using and gel filtration of C57BL/6J kidney homogenates. Purified ES-2 was used to elicit antisera from New... in kidney. . Page 28 LIST OF FIGURES Page 1. Heat curves. 14 2. Immunoelectrophoretic rockets of purified ES-2. 15 3. Rocket areas vs. purified ES-2. 16 4. Starch gel of purified ES-2 18 5. Crossed electrophoresis 19 6. Immunoelectrophoretic...

Deal, Frank Hans

1981-01-01T23:59:59.000Z

428

Geometrically Decoupled Phased Array Coils for Mouse Imaging  

E-Print Network [OSTI]

B] measurements with flux probe????...???.. ..... 54 47 Circuit showing position of the tuning and matching capacitors .............. 70 48 Central core and shield of the semi rigid cable??????????. 72 49 Stepwise construction of a balun....16cms) (Figure 9(a)). The protel file for the endrings with 2 sizes of apertures is saved on the d:/Sahil/endringsmall.pcb and d:/Users/Sahil/endringlarge.pcb (Figure 9(b)). Two of these structures were stuck together using plastic epoxy...

Bhatia, Sahil

2010-07-14T23:59:59.000Z

429

A Systematic Analysis of a Deep Mouse Epididymal Sperm Proteome...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

energy production via glycolysis, ?-oxidation and oxidative phosphorylation, protein folding and transport, and cell signaling systems. This proteome should prove a useful...

430

Static and dynamic tactile directional cues experiments with VTPlayer mouse  

E-Print Network [OSTI]

, is a track- ball: the braille cell replaces the scrolling wheel. The second one is called Tacti] added a 2Ã?4 braille cell on three devices to add tactile information. The first one, called TactiBall

Paris-Sud XI, Université de

431

Uterine deletion of Trp53 compromises antioxidant responses in mouse  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched Ferromagnetism inS-4500II Field EmissionFunctional MaterialsRobert

432

Characterization of individual mouse cerebrospinal fluid proteomes. | EMSL  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed New Substation SitesStandingtheir Atmospheric Impacts. |Characterizationindividual

433

Characterization of the Mouse Brain Proteome Using Global Proteomic  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed New Substation SitesStandingtheir AtmosphericAnalysis Complemented with

434

The mouse visually evoked potential : neural correlates and functional applications  

E-Print Network [OSTI]

The visually evoked potential (VEP) is a local field potential (LFP) evoked in visual cortex in response to visual stimuli. Unlike extracellular single unit recordings, which allow us to probe the function of single spiking ...

Muhammad, Rahmat

2009-01-01T23:59:59.000Z

435

Reverse Genetics System for Mouse Hepatitis Virus Strain 1  

E-Print Network [OSTI]

the virus has entered the target cell, it begins to translate viral replication proteins and then to copy the genome in order to access the structural genes needed to make progeny virus. The entire replication cycle takes place in the cytoplasm of the host... to the 3? UTR of MHV, it does not provide access to genes upstream of the S gene, leaving only 1/3 of the genome available for analysis (50). The other two thirds of the genome consists of ORF1a and ORF1b, which contain the replicase genes. These genes...

Carter, Kristen

2011-04-19T23:59:59.000Z

436

Mammalian genetics pioneer Liane Russell writes Mouse House history |  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: VegetationEquipment Surfaces and InterfacesAdministration -Lowellfor 2013Malcolm J. Andrews,

437

Comparative Analysis of Proteome and Transcriptome Variation in Mouse. |  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed New SubstationCleanCommunity Involvement and Making aCompactCompany Template

438

Proteomic Identification and Quantification of S-glutathionylation in Mouse  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 - SeptemberMicroneedlesAdvanced Photon Source Thecharacterization

439

Effects of Systemic Inflammation on Synaptogenesis in Developing Mouse Hippocampus  

E-Print Network [OSTI]

Neurosci 28(3):117-119. Battaglia FP, Benchenane K, SirotaY,Gross CG, Kopil C, Battaglia L, McBreen M, Stranahan AM,Neurosci 28(3):117-119. Battaglia FP, Benchenane K, Sirota

Sloniowski, Slawomir

2011-01-01T23:59:59.000Z

440

Monitoring transient repolarization segment morphology deviations in mouse ECG  

E-Print Network [OSTI]

This thesis details the design, implementation and validation of a system that facilitates partial automation for detection of anomalous repolarization segment morphologies in the ECG of mice. The technology consists of ...

Oefinger, Matthew Blake, 1976-

2006-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Cochlear hair cell regeneration from neonatal mouse supporting cells  

E-Print Network [OSTI]

Unlike lower vertebrates, capable of spontaneous hair cell regeneration, mammals experience permanent sensorineural hearing loss following hair cell damage. Although low levels of hair cell regeneration have been demonstrated ...

Bramhall, Naomi F

2012-01-01T23:59:59.000Z

442

E-Print Network 3.0 - area ames iowa Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

29 Barn Swallow Breeding habitat usually contains open areas (fields, meadows, farm ponds, marshes, CRP and Summary: . Roosa. 1984. Iowa birds. Iowa State University...

443

acute myocardial infarctions: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in ST elevation myocardial infarction (STEMI) patients. Paramedics obtaining a 12 lead electrocardiogram (ECG) in the field (more) Meadows-Pitt, Mary S. 2012-01-01 187...

444

acute myocardial infarction: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in ST elevation myocardial infarction (STEMI) patients. Paramedics obtaining a 12 lead electrocardiogram (ECG) in the field (more) Meadows-Pitt, Mary S. 2012-01-01 187...

445

E-Print Network 3.0 - abutment highway bridge Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the FoundersMeadows bridge abutments, was completed in 1999 near Denver, Colorado, USA... and approaching roadway structures. KEYWORDS: Soil Reinforcement, Bridge ... Source:...

446

Falls Dam on the Pend Oreille River.  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

is dominated by conifer forests, grassland meadows, open water ponds, emergent wetlands and shrub-scrub wetlands. This parcel of land includes about two miles of perennial...

447

www.midlothiansciencefestival.com 5th -20th October 2013  

E-Print Network [OSTI]

Danderhall GeoSciences Day Vogrie Tue 15th Oct Solar Meadows (Tour) Dalkeith Electric Future: Dalkeith Cars Squeeze Bonnyrigg Solar Meadows Dalkeith Electric Future: Dalkeith Cars and Engineering Sweet Perfection) Roslin Behind The Scenes At Roslin Roslin Biocentre Meet The Cows Roslin Langhill Farm Tour Sat 19th Oct

Maizels, Rick

448

Supplementary Information: Estimation of Pfs Specific Activity Materials. Mouse anti-polyhistidine and goat anti-mouse IgG conjugated to alkaline  

E-Print Network [OSTI]

). This was done by connecting the cathode and anode (nickel chromium wire) using alligator clips to a DC power. Estimations of Pfs specific activity. Pfs-chitosan conjugate was prepared and electrodeposited onto different

Rubloff, Gary W.

449

Protocol: Mouse Cardiac CINE Protocol, Page 1 of 2 Author: R.Bussell 8/9/2013 Protocol: Mouse Cardiac CINE Protocol  

E-Print Network [OSTI]

monitor. The leads should be twisted along their entire length and never form a loop. Tape leads securely the respiratory bellows between the animal and a hard surface so the respiratory signal is reliable. Set the bladder below the diaphragm. If the bladder is too high you may observe the heart beat in the respiratory

Squire, Larry R.

450

Reproductive strategies and natural history of the arboreal Neotropical vesper mouse, Nyctomys sumichrasti  

E-Print Network [OSTI]

, based on mass, is variable but most females are parous by 60 g. Litter size is small with a mode of 2 and embryos are not evenly distributed across the uterine horns. Vesper mice exhibit striking morphological differences in terms of tooth-wear...

Romero, Andrea; Timm, Robert M.

2013-10-01T23:59:59.000Z

451

E-Print Network 3.0 - activate mouse dorsal Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Rearrangement during Morphogenesis of the Summary: elegans Dorsal Hypodermis E. M. Williams-Masson,*, P. J. Heid, C. A. Lavin, and J. Hardin *Molecular... in the dorsal...

452

Mouse and human embryonic stem cells: can they improve human health by preventing disease?  

E-Print Network [OSTI]

94 (2), 310-321. George, S. ; Heng, B. C. ; Vinoth, K. J. ;1349. Cao, T. ; Lu, K. ; Fu, X. ; Heng, B. C. Differentiated

Talbot, Prue

2013-01-01T23:59:59.000Z

453

FoxP genes subdivide interneuron subclasses in the developing mouse spinal cord  

E-Print Network [OSTI]

in Biology by Timothy Tin Heng Wong Committee in charge:The Thesis of Timothy Tin Heng Wong is approved and it isSpinal Cord by Timothy Tin Heng Wong Master of Science in

Wong, Timothy Tin Heng

2009-01-01T23:59:59.000Z

454

System for remote multichannel real-time monitoring of mouse ECG via the Internet  

E-Print Network [OSTI]

A hardware/software system was developed to allow real-time monitoring of multiple physiological signals simultaneously via the Internet. The hardware is specifically designed for measuring ECG signals from mice, while the ...

Oefinger, Matthew Blake, 1976-

2003-01-01T23:59:59.000Z

455

E-Print Network 3.0 - ames dwarf mouse Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

object is a brown dwarf. However, the use of this so-called lithium Source: Stancil, Phillip C. - Department of Physics and Astronomy, University of Georgia Collection: Physics...

456

The effects of adult male mouse urine odor on evoked potentials in adult female mice  

E-Print Network [OSTI]

collected with EEG electrodes placed within a cup of physiological saline solution and SCI-LAB turned on Power spectrum of data collected with EEG electrodes placed within a cup of physiological saline solution and SCI-LAB turned off 56 10. Power... spectrum (test 1) of data collected with EEG electrodes tied together and placed within a cup of physiological saline solution 59 power spectrum (test 2) of data collected with EEG electrodes tied together and placed within a cup of physiological...

Brown, Troy Edwin

2012-06-07T23:59:59.000Z

457

Characterization of Urinary Iron Loss in the fsn (flaky skin) Anemia Mouse Mutant  

E-Print Network [OSTI]

., Ashland, OR) gating on live cells and excluding doublets. Gating was based on unstained and isotype controls. Western Blot of kidney samples and Antibodies fsn and WT littermate kidney was dissected after 4 weeks on a high iron diet. Half...

Kress, Robert Lee

2014-08-31T23:59:59.000Z

458

Intravital imaging of amyloid plaques in a transgenic mouse model using optical-resolution  

E-Print Network [OSTI]

; revised November 10, 2009; accepted November 10, 2009; posted November 12, 2009 (Doc. ID 114001 to play a major role in the pathogen- esis of Alzheimer's disease (AD), but the underlying mechanisms

Wang, Lihong

459

Associations Between Paternal Responsiveness and Stress Responsiveness in the Biparental California Mouse, Peromyscus californicus  

E-Print Network [OSTI]

receptor antagonist, s179d-prl, delay the onset of maternalsion of the peptides prolactin (PRL) and oxytocin (OT), andChanges in peripheral PRL levels in fathers of several

Chauke, Miyetani

2012-01-01T23:59:59.000Z

460

Impaired Adult Neurogenesis in the Dentate Gyrus of a Triple Transgenic Mouse Model of Alzheimer's Disease  

E-Print Network [OSTI]

Masashi Tabuchi 1 , Stuart M. Allan 1 , Elysse M. Knight 1 ,JJ, Jones VC, Tabuchi M, Allan SM, Knight EM, et al. (2008)

2008-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Analysis of pluripotent mouse stem cell proteomes : insights into post- transcriptional regulation of pluripotency and differentiation  

E-Print Network [OSTI]

Protein KIAA1967 ho 589.07 Vim Vimentin 273.11 Etfa Electron2610301G19RikIPI00123624 Vim IPI00227299 Etfa IPI00116753375.33 substrate Prkar2b Cfl2 Vim IPI00224570 IPI00266188

O'Brien, Robert Norman

2010-01-01T23:59:59.000Z

462

Investigations into arsenate-induced neural tube defects in a mouse model  

E-Print Network [OSTI]

in drinking water and increased risk of congenital heart malformations in exposed offspring (22; 29) The first study explored the relationship between the population- weighted mean arsenic concentration in public drinking water supplies, and mortality from.../l. In the second study, information concerning 270 cases and 665 control children was used to identify maternal exposures to drinking water contaminants associated with increased 5 risks for congenital heart disease. Arsenic exposure at any detectable level...

Hill, Denise Suzanne

2009-05-15T23:59:59.000Z

463

Phenotypic Evolution of Therapeutic Salmonella enterica Serovar Typhimurium after Invasion of TRAMP Mouse Prostate Tumor  

E-Print Network [OSTI]

Salmonella has been of interest in cancer research due to its intrinsic ability to selectively target and colonize within tumors, leading to tumor cell death. Current research indicates promising use of Salmonella in regular ...

Choe, Elizabeth

464

E-Print Network 3.0 - accelerated mouse sam Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

decision makers can choose among solar, wind, and Summary: to the National Renewable Energy Laboratory (NREL). NREL has developed a tool--the System Advisor Model (SAM... and...

465

Mitochondrial dysfunction in mouse models of Parkinson’s disease revealed by transcriptomics and proteomics  

E-Print Network [OSTI]

J Bioenerg Biomembr (2009) 41:487–491 DOI 10.1007/s10863-nitrogen species (RNS). J Bioenerg Biomembr (2009) 41:487–MPTP and methamphetamine J Bioenerg Biomembr (2009) 41:487–

Smith, Desmond J.

2009-01-01T23:59:59.000Z

466

Did "Minority Report" Get it Wrong? Superiority of the Mouse over 3D Input Devices  

E-Print Network [OSTI]

-specialists (e.g., Google Earth, Sketchup) has focused increased attention on the problem of improved interaction

Cooperstock, Jeremy R.

467

Investigating the consequences of chromosome abnormalities arising during pre-implantation development of the mouse  

E-Print Network [OSTI]

instrumental in making the Institute a first-class environment to work in. For enjoyable and productive collaborations I wish to thank Dr Thierry Voet for the array-based karyotyping experiments and also Aisha Elaimi together with Joyce Harper for FISH... at serine residue 139) hCG – Human Chorionic Gonadotrophin hES cells – Human Embryonic Stem Cells H4K20me2 – Dimethylation of Histone4 At Lysine Residue 20 H2 O 2 – Hydrogen Peroxide ICC - Immunocytochemistry ICM – Inner Cell Mass ICSI – Intra...

Bolton, Helen Louise

2014-02-04T23:59:59.000Z

468

Cell-cell and cell-medium interactions in the growth of mouse embryonic stem cells  

E-Print Network [OSTI]

Embryonic stem cells serve as powerful models for the study of development and disease and hold enormous potential for future therapeutics. Due to the potential for embryonic stem cells (ESCs) to provide a variety of tissues ...

Mittal, Nikhil, 1979-

2010-01-01T23:59:59.000Z

469

Guiding the osteogenic fate of mouse and human mesenchymal stem cells through feedback system control  

E-Print Network [OSTI]

3, S32–38 (2009). 37. Diefenderfer, D. L. , Osyczka, A. M. ,1, 38. Osyczka, A. M. , Diefenderfer, D. L. , Bhargave, G. &

Honda, Y; Ding, X; Mussano, F; Wiberg, A; Ho, C-M; Nishimura, I

2013-01-01T23:59:59.000Z

470

Mechanisms of ocular dominance plasticity in the juvenile and adult mouse visual cortex  

E-Print Network [OSTI]

Ocular dominance (OD) plasticity is a classic example of bidirectional experience-dependent plasticity in the primary visual cortex. This form of plasticity is most robust during early postnatal development (termed the ...

Khibnik, Lena A

2011-01-01T23:59:59.000Z

471

Metabolism of vitamin K in Swiss 3T3 mouse fibroblasts  

E-Print Network [OSTI]

the carboxylation of blood proteins, induce GLU VITAMIN K CYCLE GLA K Carboxylase K Epoxidase HHO I I II -N-C-C- + CO~+ 0~ I H-C-H I H-C-H I COOH H HO I I II -N-CM- I H-C-H I H-C HOOC COOH / X CHs OH K red. K Epoxide Reductase 0 CHs...

Johnson, Terryl Marie

1985-01-01T23:59:59.000Z

472

Genomic Imprinting Variations in the Mouse Type 3 Deiodinase Gene Between Tissues and Brain Regions  

E-Print Network [OSTI]

following the manufacturers di- rections (TKT4 and TKT3 from Siemens, Washington, DC). Serum TSH was determined by RIA as previously described (9). DNA and RNA isolation and Northern and Southern analysis Total RNA and poly (A#3;) RNA were isolated from...

Martinez, M. Elena; Charalambous, Marika; Saferali, Aabida; Fiering, Steven; Naumova, Anna K.; St. Germain, Donald; Ferguson-Smith, Anne C.; Hernandez, Arturo

2014-09-18T23:59:59.000Z

473

Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis  

SciTech Connect (OSTI)

Histone deacetylase (HDAC) inhibitors are promising new compounds for the therapy of fibrotic diseases. In this study we compared the effect of two HDAC inhibitors, trichostatin A and valproic acid, in an experimental model of kidney fibrosis. In mice, doxorubicin (adriamycin) can cause nephropathy characterized by chronic proteinuria, glomerular damage and interstitial inflammation and fibrosis, as seen in human focal segmental glomerulosclerosis. Two treatment regimens were applied, treatment was either started prior to the doxorubicin insult or delayed until a significant degree of proteinuria and fibrosis was present. Pre-treatment of trichostatin A significantly hampered glomerulosclerosis and tubulointerstitial fibrosis, as did the pre-treatment with valproic acid. In contrast, the development of proteinuria was only completely inhibited in the pre-treated valproic acid group, and not in the pre-treated trichostatin A animals. In the postponed treatment with valproic acid, a complete resolution of established doxorubicin-induced proteinuria was achieved within three days, whereas trichostatin A could not correct proteinuria in such a treatment regimen. However, both postponed regimens have comparable efficacy in maintaining the kidney fibrosis to the level reached at the start of the treatments. Moreover, not only the process of fibrosis, but also renal inflammation was attenuated by both HDAC inhibitors. Our data confirm a role for HDACs in renal fibrogenesis and point towards a therapeutic potential for HDAC inhibitors. The effect on renal disease progression and manifestation can however be different for individual HDAC inhibitors. - Highlights: • Valproic acid is a potent antiproteinuric drug, whereas trichostatin A is not. • Trichostatin A and valproic acid reduce kidney fibrosis in doxorubicin nephropathy. • Both valproic acid and trichostatin A attenuate renal inflammation.

Van Beneden, Katrien, E-mail: kvbenede@vub.ac.be [Department of Human Anatomy, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium); Geers, Caroline [Department of Pathology, Universitair Ziekenhuis Brussel, Brussels (Belgium); Pauwels, Marina [Department of Human Anatomy, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium); Mannaerts, Inge [Department of Cell Biology, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium); Wissing, Karl M. [Department of Nephrology, Universitair Ziekenhuis Brussel, Brussels (Belgium); Van den Branden, Christiane [Department of Human Anatomy, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium); Grunsven, Leo A. van, E-mail: lvgrunsv@vub.ac.be [Department of Cell Biology, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium)

2013-09-01T23:59:59.000Z

474

E-Print Network 3.0 - apolipoprotein e-deficient mouse Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

17 Research report Summary: , Grauer E, Sehayek E, Michaelson DM. Biochem- ical and cognitive studies of apolipoprotein-E-deficient... . Memory deficits and cholinergic...

475

E-Print Network 3.0 - adult mouse olfactory Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

olfactory bulb has around 3000glomeruli(Meisami, 1979); a similararrange- ... Source: Vogt, Richard G. - Department of Biological Sciences, University of South Carolina...

476

TRP channel gene expression in the mouse retina Jared C. Gilliam, Theodore G. Wensel  

E-Print Network [OSTI]

1 in the photoreceptor inner segment layer, for TRPM1 in the inner nuclear layer (INL), for TRPM3 in the INL, and for TRPML1 in the outer plexiform and nuclear layers. Strong immunofluorescence signal in cone outer segments was observed for TRPM7 and TRPP2. TRPC5 immunostaining was largely confined to INL

Wensel, Theodore G.

477

Transplacental transfer of immune antibodies in the mouse demonstrated by antibody labeled in vivo with tritium  

E-Print Network [OSTI]

in this manner are valid only for the iso- tope used in their construction and only when the same counting conditions prevail such as machine settings, coctail formula, type of quencher present, and counting temperature. 39 VITA Hubert E. McKinney was born...

McKinney, Hubert Eugene

1971-01-01T23:59:59.000Z

478

Natural history and karyology of the Yucatán vesper mouse, Otonyctomys hatti  

E-Print Network [OSTI]

G41G62G73G74G72G61G63G74 G53G65G76G65G6EG74G65G65G6EG20G73G70G65G63G69G6DG65G6EG73G20G6FG66G20G74G68G65G20G72G61G72G65G20G59G75G63G61G74GE1G6EG20G76G65G73G70G65G72G20G6DG6FG75G73G65G2C G4FG74G6FG6EG79G63G74G6FG6DG79G73G20G68G61G74G74G69G2CG20G61G72G...65G20G6EG6FG77G20G6BG6EG6FG77G6EG20G66G72G6FG6DG20G42G65G6CG69G7AG65G2CG20G47G75G61G74G65G2D G6DG61G6CG61G2CG20G61G6EG64G20G74G68G65G20G4DG65G78G69G63G61G6EG20G73G74G61G74G65G73G20G6FG66G20G43G61G6DG70G65G63G68G65G2CG20G51G75G69G6EG74G61G6EG61 G52G6FG...

Genoways, Hugh H.; Timm, Robert M.; Engstrom, Mark D.

2005-01-01T23:59:59.000Z

479

DCAMKL-1 expression identifies tuft cells rather than stem cells in the adult mouse intestinal epithelium  

E-Print Network [OSTI]

differentiation markers. Tuft cells, also known as brush, caveolated, multivesicular or fibrillovesicular cells, are found in the hollow organs of the GI tract and in respiratory organs 6 . They are reliably distinguished

Boyer, Edmond

480

THE DYNAMIC RELATIONSHIP BETWEEN LANGERHANS CELLS AND INTRAEPIDERMAL NERVE FIBERS IN THE MOUSE AND RAT FOOTPAD  

E-Print Network [OSTI]

Skin disorders are often associated with immune and nervous system dysfunction. Intraepidermal nerve fibers (IENFs) detect mechanical, thermal, and noxious stimuli. Although immune cells such as mast and T cells can alter ...

Doss, Argenia Lanisha Necole

2011-12-31T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Molecular taxonomy of major neuronal classes in the adult mouse forebrain  

E-Print Network [OSTI]

of specific neuronal circuit elements. The mammalian forebrain is a tissue of stunning complexity comprised to which a single canonical circuit comprised of a set of canonical cell types can be recognized across of characteristics including anatomical location, intrinsic firing properties, synaptic physiology, somatodendritic

Cai, Long

482

Geometric representation of neuroanatomical data observed in mouse brain at cellular and gross levels  

E-Print Network [OSTI]

This dissertation studies two problems related to geometric representation of neuroanatomical data: (i) spatial representation and organization of individual neurons, and (ii) reconstruction of three-dimensional neuroanatomical regions from sparse...

Koh, Wonryull

2009-05-15T23:59:59.000Z

483

The Sex Chromosome Trisomy mouse model of XXY and XYY: metabolism and motor performance  

E-Print Network [OSTI]

breast cancer [19,20], osteoporosis [21,22], and autoimmunee.g. , hypogonadism, osteoporosis, and learning and socialDi MA, Vinanzi C, Foresta C: Osteoporosis in Klinefelter's

2013-01-01T23:59:59.000Z

484

Mouse and human embryonic stem cells: can they improve human health by preventing disease?  

E-Print Network [OSTI]

diseases, they also have equally great potential to prevent disease by identifying dangerous environmental chemicals

Talbot, Prue

2013-01-01T23:59:59.000Z

485

UPTAKE OF [3H]-COLCHICINE INTO BRAIN AND LIVER OF MOUSE, RAT, AND CHICK  

E-Print Network [OSTI]

by M.R. Rosenzweig and E.l. Bennett, Cambridge, MA: The MITJ.F. , D.W. landry, E.l. Bennett, and M.E. Jarvik. long-termRAT,AND CHICK Edward L. Bennett, Marie Hebert Alberti, and

Bennett, Edward L.

2010-01-01T23:59:59.000Z

486

The tumor cells were derived from primary mouse medulloblastomas, which are cerebel-  

E-Print Network [OSTI]

the active compound classes, which suggests that common off- target effects are unlikely, and inhibition of the antiproliferative effect of the D2/3 dopa- mine receptor agonist bromocriptine by coad- ministration of the D2 with Parkinson disease10. Finally, the possibility that neu- rotransmitters are involved in cancer stem cell self

Doyle, Patrick S.

487

Identification of a Mouse Thiamine Transporter Gene as a Direct Transcriptional Target for p53*  

E-Print Network [OSTI]

- mine transporter activities were found in cells overex- pressing mTHTR-1 and under conditions of DNA damage or p53 activation. Our findings indicate that p53 may be involved in maintaining thiamine frequent events in human cancers. p53 has been shown to inhibit cell cycle progression, promote apoptosis

Lin, Chi-Hung

488

Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate  

E-Print Network [OSTI]

compensatory responses offering protection against stress, promoting growth of neuronal processes (neurites) and re-establishment of synapses. The transcription of a key gene in the neurite growth network, the kinase Ptk2b, was significantly up-regulated in Tg...

Wang, Xinkun; Bao, Xiaodong; Pal, Ranu; Agbas, Abdulbaki; Michaelis, Elias K.

2010-06-07T23:59:59.000Z

489

Odorant Receptor Expression Defines Functional Units in the Mouse Olfactory System  

E-Print Network [OSTI]

) and influ- ence the guidance of OSN axons to synaptic targets in the olfactory bulb (OB). OSNs expressing of single neurons from gene- targeted mice in which the green fluorescent protein is coex- pressed and arrangement of glomerular functional units. Key words: olfaction; olfactory system; olfactory bulb; glo

Bozza, Thomas

490

E-Print Network 3.0 - adult mouse brain Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

(Brd... U) labelling, that cell proliferation does occur in the Drosophila ... Source: Brand, Andrea - Department of Genetics, University of Cambridge Collection: Biology and...

491

Magnetic Resonance Imaging Indicates Decreased Choroidal and Retinal Blood Flow in the DBA/2J Mouse  

E-Print Network [OSTI]

proteins: tyrosinase-related protein 1 (Tyrp1), which causes iris stromal atrophy,6 and glycoprotein

Duong, Timothy Q.

492

NOTCH2 REGULATES BMP4 AND MORPHOGENESIS IN THE DEVELOPING MOUSE CILIARY BODY  

E-Print Network [OSTI]

= Pituitary tumor-transforming 1 rSMAD = Receptor - mothers against decapentaplegic homolog SMAD = Mothers against decapentaplegic homolog TGF-? = Transforming growth factor-beta Tryp = Tyrosinase-related protein Wnt2b = Wingless-type MMTV integration... of the tyrosinase gene as a phenotype enhancer for both CYP1b1-/- and FOXC1-/- mice. Treatment of subsequent CYP1b1-/- albino mice with L-dopa in utero led to a remarkable rescuing of the phenotype. This provides an outstanding example of the necessity...

Tanzie, Christopher Patrick

2011-08-31T23:59:59.000Z

493

Time course and progression of wild type ¿-Synuclein accumulation in a transgenic mouse model  

E-Print Network [OSTI]

cerebral cortex (RSC, S1, Pir, CA1-3, M2, oCx), subcorticalOlf), piriform cortex (Pir), retrosplenial cortex (RSC),

2013-01-01T23:59:59.000Z

494

Characterisation of microRNA expression in post-natal mouse mammary gland development  

E-Print Network [OSTI]

. For example during puberty and gestation, proliferation and associated processes of cell division and mitosis were highly represented, cal- cium/sodium ion transport, translation and intracellular protein transport were prominent during lactation, apop- tosis... and miR-429. There is increasing evidence that this miRNA family plays a crucial role in the regulation of epithelial to mesenchy- mal transition (EMT). All five members of the miR-200 family were markedly down-regulated in cells that had undergone EMT...

Avril-Sassen, Stefanie; Goldstein, Leonard D; Stingl, John; Blenkiron, Cherie; Le Quesne, John; Spiteri, Inmaculada; Karagavriilidou, Konstantina; Watson, Christine J; Tavare, Simon; Miska, Eric A; Caldas, Carlos

2009-11-20T23:59:59.000Z

495

Phase contrast tomography of the mouse cochlea at microfocus x-ray sources  

SciTech Connect (OSTI)

We present phase contrast x-ray tomography of functional soft tissue within the bony cochlear capsule of mice, carried out at laboratory microfocus sources with well-matched source, detector, geometry, and reconstruction algorithms at spatial resolutions down to 2 ?m. Contrast, data quality and resolution enable the visualization of thin membranes and nerve fibers as well as automated segmentation of surrounding bone. By complementing synchrotron radiation imaging techniques, a broad range of biomedical applications becomes possible as demonstrated for optogenetic cochlear implant research.

Bartels, Matthias; Krenkel, Martin [Institute for X-Ray Physics, University of Göttingen, Göttingen (Germany)] [Institute for X-Ray Physics, University of Göttingen, Göttingen (Germany); Hernandez, Victor H. [InnerEarLab, Department of Otolaryngology, University Medical Center Göttingen, Göttingen (Germany) [InnerEarLab, Department of Otolaryngology, University Medical Center Göttingen, Göttingen (Germany); Bernstein Focus for Neurotechnology, University of Göttingen, Göttingen (Germany); Moser, Tobias [InnerEarLab, Department of Otolaryngology, University Medical Center Göttingen, Göttingen (Germany) [InnerEarLab, Department of Otolaryngology, University Medical Center Göttingen, Göttingen (Germany); Bernstein Focus for Neurotechnology, University of Göttingen, Göttingen (Germany); Center for Nanoscopy and Molecular Physiology of the Brain, Göttingen (Germany); Salditt, Tim [Institute for X-Ray Physics, University of Göttingen, Göttingen (Germany) [Institute for X-Ray Physics, University of Göttingen, Göttingen (Germany); Center for Nanoscopy and Molecular Physiology of the Brain, Göttingen (Germany)

2013-08-19T23:59:59.000Z

496

tion. Human or mouse intestinal epithelial cells that express the poly-Ig receptor were  

E-Print Network [OSTI]

. Antibodies specific for Clostrid- ium difficile toxin A and Helicobacter pylori urease have been generated, Glauser M et al (1995) Oral immunization with Helicobacter pylori urease as a treatment against Helicobacter infection. Gas- troenterology (in press) Haneberg B, Kendall D, Amerongen HM, Apter FM

Boyer, Edmond

497

Automated, all-optical cranial surgery for transcranial imaging of mouse brain  

E-Print Network [OSTI]

E. , Ultrashort Laser Pulses. Ultrafast optics, Trenbio,T. , Chirped Pulse Amplification. Ultrafast optics, Trenbio,ultrafast laser systems [2] which produce laser pulses with

Jeong, Diana

498

Video Article Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung  

E-Print Network [OSTI]

cell culture medium with 3.5% Ficoll using a syringe pump (Cole-Parmer, Vernon Hills, IL) to generate

Chesler, Naomi C.

499

Functional Expression of the CXC-Chemokine Receptor-4/ Fusin on Mouse Microglial Cells and Astrocytes'  

E-Print Network [OSTI]

-1a (SDF-1a). Both astrocytes and microglial cells mobilized calcium following stimulation with chemically synthesized SDF-1a. SDF-la- and carbachol-mediated calcium responses of astrocytes were partially and other G proteins. In contrast, the calcium responses of microglial cells to SDF-la were completely

Springer, Timothy A.

500

anti-mouse muc6 antibody: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

(15-17) and that the interaction between CD2 and LFA-3 can mediate adhesion of J Clark; Debbie A Law; David J Paterson; Michael Puklavec; Alan; F. Williams 1988-01-01 328...