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1

Multispectral Imaging At Dixie Meadows Area (Martin, Et Al.,...  

Open Energy Info (EERE)

Martin, Et Al., 2004) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Multispectral Imaging At Dixie Meadows Area (Martin, Et Al., 2004)...

2

Meadow Creek | Open Energy Information  

Open Energy Info (EERE)

Meadow Creek Meadow Creek Jump to: navigation, search Name Meadow Creek Facility Meadow Creek Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Ridgeline Energy Developer Ridgeline Energy Energy Purchaser PacifiCorp (Rocky Mountain Power) Location Idaho Falls ID Coordinates 43.50492362°, -111.8366146° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":43.50492362,"lon":-111.8366146,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

3

Meadow Ridge | Open Energy Information  

Open Energy Info (EERE)

Ridge Ridge Jump to: navigation, search Name Meadow Ridge Facility Meadow Ridge Sector Wind energy Facility Type Community Wind Facility Status In Service Owner Meadow Ridge Wind Energy LLC (community owned) Energy Purchaser Central Iowa Power Cooperative Location Greenfield IA Coordinates 41.39004255°, -94.44637299° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":41.39004255,"lon":-94.44637299,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

4

New Meadows Biomass Facility | Open Energy Information  

Open Energy Info (EERE)

Meadows Biomass Facility Meadows Biomass Facility Jump to: navigation, search Name New Meadows Biomass Facility Facility New Meadows Sector Biomass Owner Tamarack Energy Location New Meadows, Idaho Coordinates 44.9712808°, -116.2840176° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":44.9712808,"lon":-116.2840176,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

5

Grand Meadow Wind Farm | Open Energy Information  

Open Energy Info (EERE)

Grand Meadow Wind Farm Grand Meadow Wind Farm Jump to: navigation, search Name Grand Meadow Wind Farm Facility Grand Meadow Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner EnXco Developer EnXco Energy Purchaser Xcel Energy Location Dexter MN Coordinates 43.707798°, -92.654071° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":43.707798,"lon":-92.654071,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

6

Dixie Meadows Geothermal Area | Open Energy Information  

Open Energy Info (EERE)

Dixie Meadows Geothermal Area Dixie Meadows Geothermal Area (Redirected from Dixie Meadows Area) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Geothermal Resource Area: Dixie Meadows Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8 NEPA-Related Analyses (6) 9 Exploration Activities (2) 10 References Area Overview Geothermal Area Profile Location: Nevada Exploration Region: Central Nevada Seismic Zone GEA Development Phase: None"None" is not in the list of possible values (Phase I - Resource Procurement and Identification, Phase II - Resource Exploration and Confirmation, Phase III - Permitting and Initial Development, Phase IV - Resource Production and Power Plant Construction) for this property.

7

Dixie Meadows Geothermal Area | Open Energy Information  

Open Energy Info (EERE)

Dixie Meadows Geothermal Area Dixie Meadows Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Geothermal Resource Area: Dixie Meadows Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8 NEPA-Related Analyses (6) 9 Exploration Activities (2) 10 References Area Overview Geothermal Area Profile Location: Nevada Exploration Region: Central Nevada Seismic Zone GEA Development Phase: None"None" is not in the list of possible values (Phase I - Resource Procurement and Identification, Phase II - Resource Exploration and Confirmation, Phase III - Permitting and Initial Development, Phase IV - Resource Production and Power Plant Construction) for this property.

8

Lester Meadow Geothermal Area | Open Energy Information  

Open Energy Info (EERE)

Lester Meadow Geothermal Area Lester Meadow Geothermal Area Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Geothermal Resource Area: Lester Meadow Geothermal Area Contents 1 Area Overview 2 History and Infrastructure 3 Regulatory and Environmental Issues 4 Exploration History 5 Well Field Description 6 Geology of the Area 7 Geofluid Geochemistry 8 NEPA-Related Analyses (0) 9 Exploration Activities (3) 10 References Area Overview Geothermal Area Profile Location: Washington Exploration Region: Cascades GEA Development Phase: 2008 USGS Resource Estimate Mean Reservoir Temp: Estimated Reservoir Volume: Mean Capacity: Click "Edit With Form" above to add content History and Infrastructure Operating Power Plants: 0 No geothermal plants listed. Add a new Operating Power Plant Developing Power Projects: 0

9

Lester Meadow, Washington- A Geothermal Anomaly | Open Energy Information  

Open Energy Info (EERE)

Lester Meadow, Washington- A Geothermal Anomaly Lester Meadow, Washington- A Geothermal Anomaly Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Conference Paper: Lester Meadow, Washington- A Geothermal Anomaly Details Activities (2) Areas (1) Regions (0) Abstract: Exploration of the Lester Hot Springs for geothermal potential found that a natural meadow adjacent to the hot springs represents a geothermal anomaly. This conclusion is supported by an anomaly in a thermal infrared survey, high levels of fluorine and boron from a soil survey, and the lack forest cover in the Lester meadow. These vegetation anomalies may be more common in the Cascade Mountains than realized and may be a useful indicator of the extent of geothermal activity at a location. Burlington Northern (BN) started conducting geothermal exploration in 1974 once the

10

Meadow Lake III | Open Energy Information  

Open Energy Info (EERE)

Lake III Lake III Jump to: navigation, search Name Meadow Lake III Facility Meadow Lake III Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Horizon Wind Energy Developer EDP Renewables Location Brookston IN Coordinates 40.601111°, -86.864167° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":40.601111,"lon":-86.864167,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

11

Multispectral Imaging At Dixie Meadows Area (Pickles, Et Al., 2003) | Open  

Open Energy Info (EERE)

Dixie Meadows Area (Pickles, Et Al., 2003) Dixie Meadows Area (Pickles, Et Al., 2003) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Multispectral Imaging At Dixie Meadows Area (Pickles, Et Al., 2003) Exploration Activity Details Location Dixie Meadows Area Exploration Technique Multispectral Imaging Activity Date Usefulness useful DOE-funding Unknown References W. L. Pickles, G. D. Nash, W. M. Calvin, B. A. Martini, P. A. Cocks, T. Kenedy-Bowdoin, R. B. Mac Knight, E. A. Silver, D. C. Potts, W. Foxall, P. Kasamayer, A. F. Waibel (2003) Geobotanical Remote Sensing Applied To Targeting New Geothermal Resource Locations In The Us Basin And Range With A Focus On Dixie Meadows, Nv Retrieved from "http://en.openei.org/w/index.php?title=Multispectral_Imaging_At_Dixie_Meadows_Area_(Pickles,_Et_Al.,_2003)&oldid=511005"

12

Dixie Meadows Geothermal Project | Open Energy Information  

Open Energy Info (EERE)

Geothermal Project Geothermal Project Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Development Project: Dixie Meadows Geothermal Project Project Location Information Coordinates 39.966944444444°, -117.85527777778° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":39.966944444444,"lon":-117.85527777778,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

13

Reds Meadow Hot Springs Pool & Spa Low Temperature Geothermal Facility |  

Open Energy Info (EERE)

Reds Meadow Hot Springs Pool & Spa Low Temperature Geothermal Facility Reds Meadow Hot Springs Pool & Spa Low Temperature Geothermal Facility Jump to: navigation, search Name Reds Meadow Hot Springs Pool & Spa Low Temperature Geothermal Facility Facility Reds Meadow Hot Springs Sector Geothermal energy Type Pool and Spa Location Devils Postpile Nat'l Monument, California Coordinates Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[]}

14

Meadow Town Corporation (Utility Company) | Open Energy Information  

Open Energy Info (EERE)

Town Corporation (Utility Company) Town Corporation (Utility Company) Jump to: navigation, search Name Meadow Town Corporation Place Utah Utility Id 12289 Utility Location Yes Ownership M NERC Location WECC NERC WECC Yes Activity Distribution Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png No rate schedules available. Average Rates Residential: $0.0835/kWh Commercial: $0.0800/kWh Industrial: $0.0823/kWh References ↑ "EIA Form EIA-861 Final Data File for 2010 - File1_a" Retrieved from "http://en.openei.org/w/index.php?title=Meadow_Town_Corporation_(Utility_Company)&oldid=411060"

15

Meadow Lake II (3Q10) | Open Energy Information  

Open Energy Info (EERE)

Q10) Q10) Jump to: navigation, search Name Meadow Lake II (3Q10) Facility Meadow Lake II (3Q10) Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Horizon Wind Energy Developer EDP Renewables Location Brookston IN Coordinates 40.601111°, -86.864167° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":40.601111,"lon":-86.864167,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

16

Thermal And-Or Near Infrared At Lester Meadow Area (Vice, 2010) | Open  

Open Energy Info (EERE)

source source History View New Pages Recent Changes All Special Pages Semantic Search/Querying Get Involved Help Apps Datasets Community Login | Sign Up Search Page Edit History Facebook icon Twitter icon » Thermal And-Or Near Infrared At Lester Meadow Area (Vice, 2010) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Thermal And-Or Near Infrared At Lester Meadow Area (Vice, 2010) Exploration Activity Details Location Lester Meadow Area Exploration Technique Thermal And-Or Near Infrared Activity Date Usefulness useful DOE-funding Unknown Notes The first TIR survey BN conducted was over the Lester Hot Springs area to see if it would help outline the area of geothermal activity. These studies found extensive thermal springs and a grassland area caused by the thermal

17

Meadow Lake IV | Open Energy Information  

Open Energy Info (EERE)

Meadow Lake IV Meadow Lake IV Facility Meadow Lake IV Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Horizon Wind Energy Developer EDP Renewables Location Brookston IN Coordinates 40.601111°, -86.864167° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":40.601111,"lon":-86.864167,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

18

Meadow Lake II | Open Energy Information  

Open Energy Info (EERE)

Meadow Lake II Meadow Lake II Facility Meadow Lake II Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Horizon Wind Energy Developer EDP Renewables Location Brookston IN Coordinates 40.601111°, -86.864167° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":40.601111,"lon":-86.864167,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

19

Restore McComas Meadows; Meadow Creek Watershed, 2005-2006 Annual Report.  

SciTech Connect (OSTI)

The Nez Perce Tribe Department of Fisheries Resource Management, Watershed Division approaches watershed restoration with a ridge-top to ridge-top approach. Watershed restoration projects within the Meadow Creek watershed are coordinated and cost shared with the Nez Perce National Forest. The Nez Perce Tribe began watershed restoration projects within the Meadow Creek watershed of the South Fork Clearwater River in 1996. Progress has been made in restoring the watershed by excluding cattle from critical riparian areas through fencing, planting trees in riparian areas within the meadow and its tributaries, prioritizing culverts for replacement to accommodate fish passage, and decommissioning roads to reduce sediment input. During this contract period work was completed on two culvert replacement projects; Doe Creek and a tributary to Meadow Creek. Additionally construction was also completed for the ditch restoration project within McComas Meadows. Monitoring for project effectiveness and trends in watershed conditions was also completed. Road decommissioning monitoring, as well as stream temperature, sediment, and discharge were completed.

McRoberts, Heidi (Nez Perce Tribe, Department of Fisheries Resource Management, Lapwai, ID)

2006-07-01T23:59:59.000Z

20

Microsoft Word - LuckiamuteMeadows_CX.docx  

Broader source: Energy.gov (indexed) [DOE]

3 3 REPLY TO ATTN OF: KEC-4 SUBJECT: Environmental Clearance Memorandum Dorie Welch Project Manager - KEWM-4 Proposed Action: Luckiamute Meadows property funding. Fish and Wildlife Project No.: 2011-003-00, Contract # BPA-007071 Categorical Exclusion Applied (from Subpart D, 10 C.F.R. Part 1021): B1.25 Real Property transfers for cultural protection, habitat preservation and wildlife management. Location: Kings Valley quadrangle, in Benton County, Oregon (near Kings Valley, Oregon) Proposed by: Bonneville Power Administration (BPA) Description of the Proposed Action: The BPA is proposing to fund the Greenbelt Trust's purchase of the Luckiamute Meadows property (Property), a 73.6-acre parcel of land located just east of Kings Valley

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Truckee Meadows Community College and Colorado School of Mines...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Student Competitions Truckee Meadows Community College and Colorado School of Mines Win Geothermal Student Competitions October 9, 2014 - 9:09am Addthis The Energy Department...

22

Meadow Lake Wind Farm | Open Energy Information  

Open Energy Info (EERE)

Wind Farm Wind Farm Facility Meadow Lake Wind Farm Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Horizon Wind Energy Developer EDP Renewables Location Brookston IN Coordinates 40.601111°, -86.864167° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":40.601111,"lon":-86.864167,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

23

Artificial leaf jumps developmental hurdle  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Bisfuel Picture Gallery Artificial leaf jumps developmental hurdle 18 Feb 2014 by Jenny Green: In a recent early online edition of Nature Chemistry, ASU scientists, along with...

24

Echo Meadows Project Winter Artificial Recharge.  

SciTech Connect (OSTI)

This report discusses the findings of the Echo Meadows Project (BPA Project 2001-015-00). The main purpose of this project is to artificially recharge an alluvial aquifer, WITH water from Umatilla River during the winter high flow period. In turn, this recharged aquifer will discharge an increased flow of cool groundwater back to the river, thereby improving Umatilla River water quality and temperature. A considerable side benefit is that the Umatilla River should improve as a habitat for migration, spanning, and rearing of anadromous and resident fish. The scope of this project is to provide critical baseline information about the Echo Meadows and the associated reach of the Umatilla River. Key elements of information that has been gathered include: (1) Annual and seasonal groundwater levels in the aquifer with an emphasis on the irrigation season, (2) Groundwater hydraulic properties, particularly hydraulic conductivity and specific yield, and (3) Groundwater and Umatilla River water quality including temperature, nutrients and other indicator parameters. One of the major purposes of this data gathering was to develop input to a groundwater model of the area. The purpose of the model is to estimate our ability to recharge this aquifer using water that is only available outside of the irrigation season (December through the end of February) and to estimate the timing of groundwater return flow back to the river. We have found through the data collection and modeling efforts that this reach of the river had historically returned as much as 45 cubic feet per second (cfs) of water to the Umatilla River during the summer and early fall. However, this return flow was reduced to as low as 10 cfs primarily due to reduced quantities of irrigation application, gain in irrigation efficiencies and increased groundwater pumping. Our modeling indicated that it is possible to restore these critical return flows using applied water outside of the irrigation season. We further found that this water can be timed to return to the river during the desired time of the year (summer to early fall). This is because the river stage, which remains relatively high until this time, drops during the irrigation season-thereby releasing the stored groundwater and increasing river flows. A significant side benefit is that these enhanced groundwater return flows will be clean and cold, particularly as compared to the Umatilla River. We also believe that this same type of application of water could be done and the resulting stream flows could be realized in other watersheds throughout the Pacific Northwest. This means that it is critical to compare the results from this baseline report to the full implementation of the project in the next phase. As previously stated, this report only discusses the results of data gathered during the baseline phase of this project. We have attempted to make the data that has been gathered accessible with the enclosed databases and spreadsheets. We provide computer links in this report to the databases so that interested parties can fully evaluate the data that has been gathered. However, we cannot emphasize too strongly that the real value of this project is to implement the phases to come, compare the results of these future phases to this baseline and develop the science and strategies to successfully implement this concept to other rivers in the Pacific Northwest. The results from our verified and calibrated groundwater model matches the observed groundwater data and trends collected during the baseline phase. The modeling results indicate that the return flows may increase to their historic values with the addition of 1 acre-ft/acre of recharge water to the groundwater system (about 9,600 acre-feet total). What this means is that through continued recharge project, you can double to quadruple the annual baseflow of the Umatilla River during the low summer and fall flow periods as compared to the present base-flow. The cool and high quality recharge water is a significant beneficial impact to the river system.

Ziari, Fred

2002-12-19T23:59:59.000Z

25

Microsoft Word - FarmPowerMistyMeadows_CX_2012.docx  

Broader source: Energy.gov (indexed) [DOE]

0, 2012 0, 2012 REPLY TO ATTN OF: KEC-4 SUBJECT: Environmental Clearance Memorandum James Hall Project Manager - TPC-TPP-4 Proposed Action: Integration of the Farm Power Misty Meadows Generating Facility Categorical Exclusion Applied (from Subpart D, 10 C.F.R. Part 1021): B1.7 - Electric equipment Location: Tillamook County, Oregon Proposed by: Bonneville Power Administration (BPA) Description of the Proposed Action: In response to Farm Power Misty Meadow's (Farm Power's) small generator interconnection request, BPA is planning to integrate their 1-MW biomass generation project into its balancing authority (BA). The proposed point of interconnection is Tillamook PUD's Feeder Circuit #63, which is connected to the Tillamook PUD's Wilson River Substation. In order to integrate the

26

Relaxation jumps of strong vibration  

Science Journals Connector (OSTI)

A nonperturbative theory of two-phonon relaxation of a strongly excited local mode is developed, whereby the mode is considered classically and phonons, quantum mechanically. The relaxation mechanism is analogous to that of black hole emission proposed by Hawking: it consists of linear transformation of phonon operators in time, which is induced by the classical subsystem (mode). Due to this transformation the number of phonons increases while the energy of the local mode decreases in time. It is found that there exist some critical energies of the local mode when relaxation rate is strongly enhanced. Thereby relaxation jumps take place, which are accompanied by generation of bursts of phonons. The values of the critical energies do not depend on temperature. The final stage of relaxation is exponential, in agreement with perturbation theory. Numerical calculations of the relaxation jumps are presented.

V. Hizhnyakov

1996-06-01T23:59:59.000Z

27

Close Out Report for the Meadow Marsh Operable Unit I Area of Concern 8  

E-Print Network [OSTI]

, designated as Area of Concern (AOC) 8, also known as the Upland Recharge/Meadow Marsh Area, was the site Treatment Plant (STP) were applied to various study areas within this AOC. Prior to remediation, the area

28

Abies lasiocarpa establishment of subalpine meadows in Glacier National Park, Montana  

E-Print Network [OSTI]

, and forest establishment. Both forest and meadow categories showed significant inverse trends in Pacific Decadal Oscillation and establishment. These data indicate warmer fall temperatures and alteration in snowpack lengthen the growing season and provide...

29

Soil Carbon in Montane Meadows Modulated by Climate and Vegetation along an  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Soil Carbon in Montane Meadows Modulated by Climate and Vegetation along an Soil Carbon in Montane Meadows Modulated by Climate and Vegetation along an Elevation Gradient Speaker(s): Marc Fischer Date: September 25, 1998 - 12:00pm Location: 90-3148 Release or uptake of soil carbon has the potential to affect atmospheric carbon dioxide concentrations and hence feedback to greenhouse gas forced climate change. We conducted extensive observations of soil carbon cycling in three montane meadows spaced at elevation intervals (~300 m) that effect average temperature variations in the range expected under a doubled CO2 climate (~2 C). We find that carbon in the top 10 cm of soil can be explained (R2~0.7) by a simple function of plant productivity, litter quality, and soil microclimate that is derived from a steady-state model of carbon pools and flows. Because the variables used in this

30

Intestinal absorption and secretion of total and lipid phosphorus in adult sheep fed chopped meadow hay  

E-Print Network [OSTI]

Intestinal absorption and secretion of total and lipid phosphorus in adult sheep fed chopped meadow total and lipid P secretion observed between the mouth and the duodenal cannula could be accounted experiment using 144Ce as an unabsorbable marker, we observed considerable total and lipid P secretion

Paris-Sud XI, Université de

31

Jumping-Catalyst Dynamics in Nanowire Growth  

Science Journals Connector (OSTI)

Nanowire growth is generally considered a steady-state process, but oscillatory phenomena are known to often play a fundamental role. Here we identify a natural sequence of distinct growth modes, in two of which the catalyst droplet jumps periodically on and off a crystal facet. The oscillatory modes result from a mismatch between catalyst size and wire diameter; they enable growth of straight smooth-sided wires even when the droplet is too small to span the wire tip. Jumping-catalyst growth modes are seen both in computer simulations of vapor-liquid-solid growth, and in movies of Si nanowire growth obtained by insitu microscopy. Our simulations also provide new insight into nanowire kinking.

K.?W. Schwarz; J. Tersoff; S. Kodambaka; F.?M. Ross

2014-07-30T23:59:59.000Z

32

Homestead Meadows North, Texas: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

North, Texas: Energy Resources North, Texas: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 31.851497°, -106.1716463° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":31.851497,"lon":-106.1716463,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

33

White Meadow Lake, New Jersey: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

Jersey: Energy Resources Jersey: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 40.9237098°, -74.5107121° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":40.9237098,"lon":-74.5107121,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

34

New Meadows, Idaho: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

Idaho: Energy Resources Idaho: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 44.9712808°, -116.2840176° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":44.9712808,"lon":-116.2840176,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

35

Meadow Woods, Florida: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

Woods, Florida: Energy Resources Woods, Florida: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 28.3855632°, -81.366459° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":28.3855632,"lon":-81.366459,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

36

Meadows Place, Texas: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

Texas: Energy Resources Texas: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 29.6513439°, -95.5880005° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":29.6513439,"lon":-95.5880005,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

37

Rolling Meadows, Illinois: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

Illinois: Energy Resources Illinois: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 42.0841936°, -88.0131275° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":42.0841936,"lon":-88.0131275,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

38

Hidden Meadows, California: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

California: Energy Resources California: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 33.2253141°, -117.112532° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":33.2253141,"lon":-117.112532,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

39

Princeton Meadows, New Jersey: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

New Jersey: Energy Resources New Jersey: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 40.3317745°, -74.5637662° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":40.3317745,"lon":-74.5637662,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

40

Productivity, detritus formation and grazing of the seagrass Thalassia testudinum Banks in Caribbean meadows: a simulative numerical model  

E-Print Network [OSTI]

and meadows formed by the sea- grasses Zostera marina L. (eelgrass), Posidonia australis Hooker and the turtlegrass T. testudinum. A~1 al mats A ;ge -e sliced mathematical odel for coastal e o- systems containing seaweeds was developed by Belyaev et al... community in relation to temperature and biotic interactions. A comparison between the predicted and observed temporal patterns of the seagrass biomass was presented. Posi donia meadows . ? Ki rkman 5 Reid ( 1979) studied the role of P. australis...

Victoria-Rueda, Carlos Humberto

1981-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

CAPTURE OF TROJANS BY JUMPING JUPITER  

SciTech Connect (OSTI)

Jupiter Trojans are thought to be survivors of a much larger population of planetesimals that existed in the planetary region when planets formed. They can provide important constraints on the mass and properties of the planetesimal disk, and its dispersal during planet migration. Here, we tested a possibility that the Trojans were captured during the early dynamical instability among the outer planets (aka the Nice model), when the semimajor axis of Jupiter was changing as a result of scattering encounters with an ice giant. The capture occurs in this model when Jupiter's orbit and its Lagrange points become radially displaced in a scattering event and fall into a region populated by planetesimals (that previously evolved from their natal transplanetary disk to {approx}5 AU during the instability). Our numerical simulations of the new capture model, hereafter jump capture, satisfactorily reproduce the orbital distribution of the Trojans and their total mass. The jump capture is potentially capable of explaining the observed asymmetry in the number of leading and trailing Trojans. We find that the capture probability is (6-8) Multiplication-Sign 10{sup -7} for each particle in the original transplanetary disk, implying that the disk contained (3-4) Multiplication-Sign 10{sup 7} planetesimals with absolute magnitude H < 9 (corresponding to diameter D = 80 km for a 7% albedo). The disk mass inferred from this work, M{sub disk} {approx} 14-28 M{sub Earth}, is consistent with the mass deduced from recent dynamical simulations of the planetary instability.

Nesvorny, David [Department of Space Studies, Southwest Research Institute, 1050 Walnut St., Suite 300, Boulder, CO 80302 (United States); Vokrouhlicky, David [Institute of Astronomy, Charles University, V Holesovickach 2, 180 00 Prague 8 (Czech Republic); Morbidelli, Alessandro [Departement Cassiopee, University of Nice, CNRS, Observatoire de la Cote d'Azur, Nice, F-06304 (France)

2013-05-01T23:59:59.000Z

42

Survivorship of meadow voles, Microtus pennsylvanicus, from sewage sludge-treated fields  

SciTech Connect (OSTI)

A long-term field study was begun in 1977 at Miami University to evaluate the effects of land application of sewage sludge on experimental old-field communities. The effects of sludge application on toxic metal concentrations in meadow vole (Microtus pennsylvanicus) organs during the first two years of the study have been reported. During the first two years of sludge application, no detrimental effects were observed in vole survivorship as a result of sludge treatment.

Maly, M.S.

1984-06-01T23:59:59.000Z

43

Electrowetting study of jumping droplets on hydrophobic surfaces  

E-Print Network [OSTI]

Recent studies have shown that jumping-droplet-enhanced condensation has higher heat transfer than state-of-the-art dropwise condensing surfaces by -30-40%. Jumping-droplet condensation occurs due to the conversion of ...

Tio, Evelyn

2014-01-01T23:59:59.000Z

44

Lift-Off Dynamics in a Simple Jumping Robot  

Science Journals Connector (OSTI)

We study vertical jumping in a simple robot comprising an actuated mass-spring arrangement. The actuator frequency and phase are systematically varied to find optimal performance. Optimal jumps occur above and below (but not at) the robots resonant frequency f0. Two distinct jumping modes emerge: a simple jump, which is optimal above f0, is achievable with a squat maneuver, and a peculiar stutter jump, which is optimal below f0, is generated with a countermovement. A simple dynamical model reveals how optimal lift-off results from nonresonant transient dynamics.

Jeffrey Aguilar, Alex Lesov, Kurt Wiesenfeld, and Daniel I. Goldman

2012-10-26T23:59:59.000Z

45

Lift-off dynamics in a simple jumping robot  

E-Print Network [OSTI]

We study vertical jumping in a simple robot comprising an actuated mass-spring arrangement. The actuator frequency and phase are systematically varied to find optimal performance. Optimal jumps occur above and below (but not at) the robot's resonant frequency $f_0$. Two distinct jumping modes emerge: a simple jump which is optimal above $f_0$ is achievable with a squat maneuver, and a peculiar stutter jump which is optimal below $f_0$ is generated with a counter-movement. A simple dynamical model reveals how optimal lift-off results from non-resonant transient dynamics.

Jeffrey Aguilar; Alex Lesov; Kurt Wiesenfeld; Daniel I. Goldman

2012-08-30T23:59:59.000Z

46

Hamilton-Jacobi equations with jumps: asymptotic stability  

E-Print Network [OSTI]

The asymptotic stability of a global solution satisfying Hamilton-Jacobi equations with jumps will be analyzed in dependence on the strong dissipativity of the jump control function and using orbits of the differentiable flows to describe the corresponding characteristic system.

Amir Mahmood; Saima Parveen

2009-09-05T23:59:59.000Z

47

ISSN 1745-9648 Gasoline Prices Jump Up on Mondays  

E-Print Network [OSTI]

ISSN 1745-9648 Gasoline Prices Jump Up on Mondays: an Outcome of Aggressive Competition? by ?ystein Research Council is gratefully acknowledged. #12;Gasoline prices jump up on Mondays: An outcome, 2008 Abstract This paper examines Norwegian gasoline pump prices using daily station

Feigon, Brooke

48

Jump Steady Resort Space Heating Low Temperature Geothermal Facility | Open  

Open Energy Info (EERE)

Jump Steady Resort Space Heating Low Temperature Geothermal Facility Jump Steady Resort Space Heating Low Temperature Geothermal Facility Jump to: navigation, search Name Jump Steady Resort Space Heating Low Temperature Geothermal Facility Facility Jump Steady Resort Sector Geothermal energy Type Space Heating Location Buena Vista, Colorado Coordinates 38.8422178°, -106.1311288° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[]}

49

Microsoft Word - CX_FINAL_FOG_MEMALOOSE_MEADOWS_LAND_ACQUISITION_06-03-13  

Broader source: Energy.gov (indexed) [DOE]

3 3 REPLY TO ATTN OF: KEC-4 SUBJECT: Environmental Clearance Memorandum Emanuel Jaramillo Project Manager - TEP-TPP-1 Proposed Action: Memaloose Meadows Land Acquisition Project Work Order No.: Work Order #327332 Categorical Exclusion Applied (from Subpart D, 10 C.F.R. Part 1021): B1.25 Real property transfers for cultural resources protection, habitat preservation, and wildlife management Location: Township 12 North, Range 12 East, Section 6; Tax Lots 100 and 200, Wasco County, Oregon Proposed by: Bonneville Power Administration (BPA) Description of the Proposed Action: BPA proposes to fund the acquisition of two contiguous parcels consisting of a total of 14.07 acres in Wasco County, Oregon. The funding would be

50

Air Quality Scoping Study for Ash Meadows National Wildlife Refuge, Nevada (EMSI April 2007)  

SciTech Connect (OSTI)

The Desert Research Institute (DRI) is performing a scoping study as part of the U.S.Department of Energys Yucca Mountain Environmental Monitoring Systems Initiative (EMSI). The main objective is to obtain baseline air quality information for Yucca Mountain and an area surrounding the Nevada Test Site (NTS). Air quality and meteorological monitoring and sampling equipment housed in a mobile trailer (shelter) is collecting data at seven sites outside the NTS, including Ash Meadows National Wildlife Refuge, Sarcobatus Flat, Beatty, Rachel, Caliente, Pahranagat National Wildlife Refuge, and Crater Flat, and at four sites on the NTS. The trailer is stationed at any one site for approximately eight weeks at a time. Letter reports provide summaries of air quality and meteorological data, on completion of each sites sampling program.

Johann Engelbrecht, Ilias Kavouras, Dave Campbell, Scott Campbell, Steven Kohl and David Shafer

2007-04-01T23:59:59.000Z

51

Case Study: Mobile Photovoltaic System at Bechler Meadows Ranger Station, Yellowstone National Park (Brochure)  

SciTech Connect (OSTI)

The mobile PV/generator hybrid system deployed at Bechler Meadows provides a number of advantages. It reduces on-site air emissions from the generator. Batteries allow the generator to operate only at its rated power, reducing run-time and fuel consumption. Energy provided by the solar array reduces fuel consumption and run-time of the generator. The generator is off for most hours providing peace and quiet at the site. Maintenance trips from Mammoth Hot Springs to the remote site are reduced. The frequency of intrusive fuel deliveries to the pristine site is reduced. And the system gives rangers a chance to interpret Green Park values to the visiting public. As an added bonus, the system provides all these benefits at a lower cost than the basecase of using only a propane-fueled generator, reducing life cycle cost by about 26%.

Not Available

2014-03-01T23:59:59.000Z

52

Laser Temperature-Jump Spectroscopy of Intrinsically Disordered Proteins  

Science Journals Connector (OSTI)

Laser temperature-jump methods allow an experimenter to study the kinetics and dynamics of very rapid solution-phase processes, including conformational dynamics of biomolecules on time scales of nanoseconds a...

Stephen J. Hagen

2012-01-01T23:59:59.000Z

53

Lower Red River Meadow Restoration Project : Biennial Report 1996-97.  

SciTech Connect (OSTI)

The Red River has been straightened and the riparian vegetation corridor eliminated in several reaches within the watershed. The river responded by incision resulting in over-steepened banks, increased sedimentation, elevated water temperatures, depressed groundwater levels, reduced floodplain function, and degraded fish habitat. The Lower Red River Meadow Restoration Project is a multi-phase ecosystem enhancement effort that restores natural physical and biological processes and functions to stabilize the stream channel and establish high quality habitats for fish and wildlife. A natural channel restoration philosophy guides the design and on the ground activities, allowing the channel to evolve into a state of dynamic equilibrium. Two years of planning, two years of restoration in Phases I and II, and one year post-restoration monitoring are complete. By excavating new bends and reconnecting historic meanders, Phase I and II channel realignment increased channel length by 3,060 feet, decreased channel gradient by 25 percent, and increased sinuosity from 1.7 to 2.3. Cross-sectional shapes and point bars were modified to maintain deep pool habitat at low flow and to reconnect the meadow floodplain. Improved soil moisture conditions will help sustain the 31,500 native riparian plantings reestablished within these two phases. Overall, short-term restoration performance was successful. Analyses of long-term parameters document either post-restoration baseline conditions or early stages of evolution toward desired conditions. An adaptive management strategy has helped to improve restoration designs, methods, and monitoring. Lessons learned are being transferred to a variety of audiences to advance the knowledge of ecological restoration and wise management of watersheds.

LRK Communications; Wildlife Habitat Institute; Pocket Water, Inc.

2003-07-01T23:59:59.000Z

54

Circular hydraulic jump in generalized-Newtonian fluids  

E-Print Network [OSTI]

We carry out an analytical study of laminar circular hydraulic jumps, in generalized-Newtonian fluids obeying the two-parametric power-law model of Ostwald-de Waele. Under the boundary-layer approximation we obtained exact expressions determining the flow, an implicit relation for the jump radius is derived. Corresponding results for Newtonian fluids can be retrieved as a limiting case for the flow behavior index n=1, predictions are made for fluids deviating from Newtonian behavior.

Rai, Ashutosh; Poria, Swarup

2008-01-01T23:59:59.000Z

55

DOE Provides $30 Million to Jump Start Bioenergy Research Centers |  

Broader source: Energy.gov (indexed) [DOE]

30 Million to Jump Start Bioenergy Research Centers 30 Million to Jump Start Bioenergy Research Centers DOE Provides $30 Million to Jump Start Bioenergy Research Centers October 1, 2007 - 2:49pm Addthis DOE Bioenergy Research Center Investment Tops $400 Million WASHINGTON, DC-The U.S. Department of Energy (DOE) today announced it has invested nearly $30 million in end-of-fiscal-year (2007) funds to accelerate the start-up of its three new Bioenergy Research Centers, bringing total DOE Bioenergy Research Center investment to over $400 million. The three DOE Bioenergy Research Centers-located in Oak Ridge, Tennessee; Madison, Wisconsin; and near Berkeley, California-selected by DOE this June, bring together multidisciplinary teams of leading scientists to advance research needed to make cellulosic ethanol and other biofuels

56

Climate, geography, and tree establishment in Subalpine Meadows of the Olympic Mountains, Washington, U.S.A.  

SciTech Connect (OSTI)

Noticeable changes in vegetation distribution have occurred in the Pacific Northwest during the last century as trees have established in some subalpine meadows. To study the relationship of this process to climate, recently established trees were aged in six subalpine meadows in the Olympic Mountains, Washington. The sites represent three points along a steep precipitation gradient. Subalpine fir (Abies lasiocarpa) has been establishing at the dry end of the gradient, mountain hemlock (Tsuga mertensiana) at the wet end, and both species in the center. Establishment patterns were compared with deviations from the century-long average for these weather variables: winter precipitation, Palmer Drought Severity Index, and winter, October and May temperatures. Results show that establishment occurred in dry areas when weather conditions were wetter than average, and in wet areas under drier than average conditions. Establishment at central sites did not show consistent relationships with climate. If future climatic conditions continue to warm, establishment of subalpine fir in subalpine meadows in dry areas may cease and mountain hemlock may resume in wet areas. 34 refs., 5 figs., 3 tabs.

Woodward, A.; Silsbee, D.G. [Univ. of Washington, Seattle, WA (United States); Schreiner, E.G. [National Biological Service, Port Angeles, WA (United States)

1995-08-01T23:59:59.000Z

57

Genomic analysis of mouse tumorigenesis  

E-Print Network [OSTI]

The availability of the human and mouse genome sequences has spurred a growing interest in analyzing mouse models of human cancer using genomic techniques. Comparative genomic studies on mouse and human tumors can be ...

Tam, Mandy Chi-Mun

2006-01-01T23:59:59.000Z

58

Improved approximation algorithm for the jump number of interval orders  

Science Journals Connector (OSTI)

Abstract The jump number problem for posets is to find a linear extension in which the number of incomparable adjacent pairs is minimized. In this paper the class of interval orders is considered. Three 3/2-approximation algorithms for this problem have been known for some time. By a previous work of Mitas, the problem may be reformulated as a subgraph packing task. We prove that the problem reduces also to a set cover task, and we establish an improved bound of 1.484 to the approximation ratio of the jump number on interval orders.

Przemys?aw Krysztowiak

2013-01-01T23:59:59.000Z

59

E-Print Network 3.0 - analyzing quantum jumps Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

spontaneous emission is described in terms of quantum jumps 35. The method has been applied also... ensembles of trajectories with quantum jumps 8. ... Source: van der...

60

HEART RATE VARIABILITY AS DETERMINISM WITH JUMP STOCHASTIC PARAMETERS  

E-Print Network [OSTI]

HEART RATE VARIABILITY AS DETERMINISM WITH JUMP STOCHASTIC PARAMETERS JIONGXUAN ZHENG, JOE SKUFCA, AND ERIK BOLLT§ Abstract. We use measured heart rate information (RR intervals) to develop a one with persistence which causes the heart rate and rhythm system to wander about a bifurcation point. We propose

Bollt, Erik

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

The fluid dynamics of swimming by jumping in copepods  

Science Journals Connector (OSTI)

...the context of animal propulsion Copepod jumps generate...the context of animal propulsion (e.g. [38-40...ecologically important marine organisms, including...Kiorboe In press. Propulsion efficiency and imposed...predation by the carnivorous marine copepod Euchaeta elongata...

2011-01-01T23:59:59.000Z

62

The ecology of the seagrass meadows of the west coast of Florida: A community profile  

SciTech Connect (OSTI)

This report summarizes information on the ecology of seagrass meadows on the west coast of Florida, from south of Tampa Bay to Pensacola. This area contains more than 3500 ha of seagrass beds, dominated by three species, Thalasia testudinum (turtle grass), Syringodium filiforme (manatee grass), and Halodule wrightii (shoal grass). Beds occur both on the shallow, zero-energy Continental Shelf and in inshore bays and estuaries. Species ecology, distribution, biomass, and productivity of these dominant seagrass species are discussed. Seagrass beds support a very diverse and abundant algal flora and fauna, and these organisms, and seagrass detritus form the base of a productive food chain. Seagrass beds are important nursery areas providing both cover and food, for a number of commercial and sports fishery species. Along the west Florida coast, estuarine grass beds are noticeably more stressed and impacted by human activities than the more pristine nearshore beds. Urban development and dredging and filling are the major threates to seagrass beds in this region. 500 refs., 28 figs., 14 tabs.

Zieman, J.C.; Zieman, R.T. (Virginia Univ., Charlottesville, VA (USA). Dept. of Environmental Sciences)

1989-09-01T23:59:59.000Z

63

Jump River Electric Coop Inc | Open Energy Information  

Open Energy Info (EERE)

River Electric Coop Inc River Electric Coop Inc Jump to: navigation, search Name Jump River Electric Coop Inc Place Wisconsin Utility Id 9922 Utility Location Yes Ownership C NERC Location MRO Activity Distribution Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png Dual Fuel Heat Commercial Dusk to Dawn Lighting- Unmetered Member Owned Lighting Dusk to Dawn Lighting- Unmetered Rental Lighting Electric Thermal Storage Heat Commercial Large Power Peak Alert- Single Phase Commercial Large Power Peak Alert- Three Phase Commercial Single Phase Residential Three Phase Small Commercial Three-Season Heat Commercial

64

Side-Jump Effect in Paramagnetic Amorphous Metals  

E-Print Network [OSTI]

(H) that is based on. the side-jump effect. Measurements for chi, R(H), and rho of (Zr0.64Cu0.36)1-xAlx and chi for (Zr0.50Ni0.50)1-xAlx alloys are presented. The odd behavior of the Hall coefficients of these alloys and the anomalous positive Hall coefficients...

RHIE, K.; Naugle, Donald G.; O, BH; MARKERT, JT.

1993-01-01T23:59:59.000Z

65

Measuring the Balmer Jump and Effective Gravity in FGK Stars  

E-Print Network [OSTI]

It is difficult to accurately measure the effective gravity (log g) in late-type stars using broadband (eg. UBV or SDSS) or intermediate-band (uvby) photometric systems, especially when the stars can cover a range of metallicities and reddenings. However, simple spectroscopic observational and data reduction techniques can yield accurate values for log g through comparison of the Balmer jumps of low-resolution spectra with recent grids of synthetic flux spectra.

Bessell, Michael S

2007-01-01T23:59:59.000Z

66

Local Atomic-Jump Process of Iron in ? -Zr  

Science Journals Connector (OSTI)

After recoil implantation of Coulomb-excited Fe57 into ? -Zr at 24 K, 30% of the implanted atoms end up on interstitial positions where they experience large electric field gradients. Between 40 and 100 K the quadrupole splitting shrinks by a factor of 2 accompanied by a sharp decrease of the line intensity. This effect is interpreted as a localized diffusion of the Fe atoms jumping in the octahedral cage of the hcp Zr lattice.

Y. Yoshida; M. Menningen; R. Sielemann; G. Vogl; G. Weyer; K. Schrder

1988-07-11T23:59:59.000Z

67

Orthogonal jumps of wavefunction in white-noise potentials  

E-Print Network [OSTI]

We investigate the evolution of the quantum state for a free particle placed into a random external potential of white-noise type. The master equation for the density matrix is derived by means of path integral method. We propose an equivalent stochastic process where the wavefunction satisfies a nonlinear Schr\\"odinger equation except for random moments at which it shows orthogonal jumps. The relation of our work to the usual theory of quantum noise and damping is briefly discussed.

Lajos Disi

2015-01-01T23:59:59.000Z

68

Ultraviolet and Green Receptors in Principal Eyes of Jumping Spiders  

E-Print Network [OSTI]

ABSTRACT Spectral sensitivities of cells in principal eyes of the jumping spider Phidippus reqius were measured using techniques of intraceUular recording. Three types of cells were found. UV ceils had peak sensitivities at 370 nm and were over 4 log units less sensitive at wavelengths longer than 460 nm. Green-sensitive cells had spectral sensitivities which were well fit by nomogram curves peaking at 532 nm. UV-green ceils had dual peaks of sensitivity at about 370 and 525 nm, but the ratios of UV-to-green sensitivities varied over a 40:1 range from cell to cell. Moreover, responses of UV-green cells to flashes of UV light were slower than to flashes of green light. Segregation of receptor types into the known layers of receptors in these eyes could not be shown. It is concluded that jumping spiders have the potential for dichromatic color vision. The brightly colored, keen-sighted jumping spiders have long been considered the possessers of color vision. Peckham and Peckham (1894) claimed that males of a number of species ( Dendryphantes elegans, Saitis pulex, Phiddipus rufus, and Astia vittata) used color clues to identify females (of the same species)

Robert D. D~. Voe

69

Twelve Months of Air Quality Monitoring at Ash Meadows National Wildlife Refuge, Southwestern Rural Nevada, U.S.A (EMSI April 2007)  

SciTech Connect (OSTI)

The one year of air quality monitoring data collected at the Ash Meadows National Wildlife Refuge (NWR) was the final part of the air quality "Scoping Studies" for the Environmental Monitoring Systems Initiative (EMSI) in southern and central Nevada. The objective of monitoring at Ash Meadows was to examine aerosol and meteorological data, seasonal trends in aerosol and meteorological parameters as well as to examine evidence for long distance transport of some constituents. The 9,307 hectare refuge supports more than 50 springs and 24 endemic species, including the only population of the federally listed endangered Devils Hole pupfish (Cyprinodon diabolis) (U.S. Fish and Wildlife Service, 1990). Ash Meadows NWR is located in a Class II air quality area, and the aerosol measurements collected with this study are compared to those of Interagency Monitoring of Protected Visual Environments (IMPROVE) sites. Measurements taken at Ash Meadows NWR over a period of 12 months provide new baseline air quality and meteorological information for rural southwestern Nevada, specifically Nye County and the Amargosa Valley.

Engelbrecht, Johann P; Shafer, David S; Campbell, Dave; Campbell, Scott; McCurdy, Greg; Kohl, Steven D; Nikolich, George; Sheetz, Larry

2011-08-01T23:59:59.000Z

70

Temperature-jump 2D IR spectroscopy to study protein conformational dynamics  

E-Print Network [OSTI]

Temperature-jump (T-jump) two-dimensional infrared spectroscopy (2D IR) is developed, characterized, and applied to the study of protein folding and association. In solution, protein conformational changes span a wide range ...

Jones, Kevin C. (Kevin Chapman)

2012-01-01T23:59:59.000Z

71

Making Things Clearer: Exaggeration, Jumping the Gun, and The Venus Syndrome  

E-Print Network [OSTI]

1 Making Things Clearer: Exaggeration, Jumping the Gun, and The Venus Syndrome 15 April 2013 James. Jumping the Gun It has been said that I reach conclusions before the evidence warrants them. Two examples

Hansen, James E.

72

Jump-Starting Zero Energy Home Design and Student Careers | Department...  

Office of Environmental Management (EM)

Jump-Starting Zero Energy Home Design and Student Careers Jump-Starting Zero Energy Home Design and Student Careers April 24, 2014 - 9:28am Addthis University of Las Vegas 1 of 5...

73

Lift-Off Dynamics in a Simple Jumping Robot Jeffrey Aguilar  

E-Print Network [OSTI]

, is achievable with a squat maneuver, and a peculiar stutter jump, which is optimal below f0, is generated

Goodisman, Michael

74

Modeling self-potential data in the Abraham and Meadow-Hatton geothermal systems: The search for upflow zones  

SciTech Connect (OSTI)

Computer code SPXCL is a finite difference modeling algorithm that calculates the response of embedded point sources within a rectangular, two-dimensional medium. The code calculates the electrical potential anywhere in the medium from thermal or pressure sources. This code is useful in calculating self-potential measurements that may be used to locate upflow zones in geothermal systems. Beginning in 1991 data on self-potential was collected at Abraham and Meadow-Hatton Hot Springs, two of the largest thermal spring systems in Utah. In this paper, these data were modeled to determine upflow zones and source characteristics using the SPXCL code. The forward solution for fluid and heat flow models and the resulting self-potential anomalies were calculated.

Schima, S.; Wilt, M. [Lawrence Livermore National Lab., CA (United States); Ross, H. [Utah Univ. Research Inst., Salt Lake City, UT (United States)

1995-07-01T23:59:59.000Z

75

E-Print Network 3.0 - alkaline ph jump Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

NEB3 restriction buffer; extra slat prevents sample jumping... -to-anode with peristaltic pump. 14. Blot gel by alkaline transfer overnight. 12; Source: Heyer, Wolf-Dietrich -...

76

Internal geophysics (Physics of Earth's interior) Jump conditions and dynamic surface tension at permeable  

E-Print Network [OSTI]

Internal geophysics (Physics of Earth's interior) Jump conditions and dynamic surface tension of momentum across the interface, a possibly anisotropic surface tension and terms including an inter- face equals the jump of pressure; and in the presence of surface tension defined as a capillary action due

77

Inverting the Turing Jump in Complexity Theory Stephen A. Fenner \\Lambda  

E-Print Network [OSTI]

Inverting the Turing Jump in Complexity Theory Stephen A. Fenner \\Lambda Computer Science Department University of Southern Maine Abstract This paper investigates the invertibility of certain analogs­jump operators are not invertible, i.e., there is a PSPACE­hard (resp. EXP­hard) set that is not p­ time Turing

Fenner, Stephen

78

Vacancy Jumps in PdIn: Reconciling Nuclear Relaxation and Diffusion Measurements  

E-Print Network [OSTI]

Vacancy Jumps in PdIn: Reconciling Nuclear Relaxation and Diffusion Measurements Gary S. Collins Keywords: point defect, vacancy, diffusion, defect interaction, intermetallic compound, perturbed angular correlation, PAC, nuclear relaxation, diffusion mechanisms Abstract. Vacancy jump frequencies in PdIn were

Collins, Gary S.

79

Explaining the convenience yield in the WTI crude oil market using realized volatility and jumps  

Science Journals Connector (OSTI)

Abstract In this paper, we first provide an empirical evidence of the existence of intraday jumps in the crude oil price series. We then show that these jumps, in conjunction with realized volatility measures, are important in modeling the convenience yield over the 20012010 period. Our empirical results indicate that lagged jump mean only explains around 16% of the weekly convenience yield. Our best specification, including variation in inventories, 8-week realized variance and the 250-day jump mean is able to explain around 61% of the weekly convenience yield. Importantly, our results are not driven by the simultaneous determination of the various variables at work as we only use lagged variables in all regressions.

Benot Svi

2015-01-01T23:59:59.000Z

80

Discrete time approximation of decoupled Forward-Backward SDE with jumps  

E-Print Network [OSTI]

+ T n h X ti , ¯Y ti , ¯Z ti where ¯Y tn := g(X tn ) and Wi+1 := Wti+1 - Wti . In the no-jump case

Elie, Romuald

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Sinkpad: A Malleable Mouse Pad Consisted of an Elastic Material  

E-Print Network [OSTI]

the mouse wheel, and moving the mouse. To solve this problem, it is necessary to augment conventional mouse. [9] described a two-ball mouse with an additional ball to capture angular movement to provide 3DOF

Tanaka, Jiro

82

Analysis and improvements of fringe jump corrections by electronics on the JET tokamak far infrared interferometer  

SciTech Connect (OSTI)

For the Tore Supra interferometer phase measurements, an electronics had been developed electronics using field programmable gate array processors. The embedded algorithm can correct the fringe jumps. For comparison, the electronics ran at JET during the 2009 campaign. The first analysis concluded that the electronics was not correcting all the fringe jumps. An analysis of the failures led to improvements in the algorithm, which was tested during the rest of the campaign. In this article, we evaluate the increases in the performance. From the analysis of the remaining faults, further improvements are discussed for designing future boards that are foreseen for JET using the second wavelength and the Cotton-Mouton effect information.

Gil, C.; Barbuti, A.; Spuig, P. [IRFM, CEA, F-13108 Saint-Paul-lez-Durance (France); Boboc, A.; Dorling, S. [Culham Science Centre, EURATOM-CCFE Fusion Association, Abingdon, Oxon OX14 3DB (United Kingdom); Collaboration: JET EFDA Contributors

2010-10-15T23:59:59.000Z

83

Jumps and stochastic volatility in crude oil futures prices using conditional moments of integrated volatility  

Science Journals Connector (OSTI)

Abstract We evaluate alternative models of the volatility of commodity futures prices based on high-frequency intraday data from the crude oil futures markets for the October 2001December 2012 period. These models are implemented with a simple GMM estimator that matches sample moments of the realized volatility to the corresponding population moments of the integrated volatility. Models incorporating both stochastic volatility and jumps in the returns series are compared on the basis of the overall fit of the data over the full sample period and subsamples. We also find that jumps in the returns series add to the accuracy of volatility forecasts.

Christopher F. Baum; Paola Zerilli

2014-01-01T23:59:59.000Z

84

Growth Kinetics in a Lattice-Gas Model with Anisotropic Jump Probabilities  

Science Journals Connector (OSTI)

The growth of the p(22) domains in the lattice-gas model with anisotropic probabilities of atomic jumps has been investigated using the Monte Carlo simulation. The analytical approach as well as the simulation results suggest that this model exhibits the anomalously slow growth of a characteristic domain size R(t)?t15 instead of R(t)?t13 for the jump-isotropic model. The growth rate as a function of the atomic concentration has a pronounced maximum at a concentration well below the stoichiometric concentration of the p(22) phase.

Oleg M. Braun and Maxim V. Paliy

1994-10-10T23:59:59.000Z

85

Administration Marks Meadow  

E-Print Network [OSTI]

MULLINS CENTER FINE ARTS CENTER Boyden Gym Hills Totman Gym Melville Emerson Knowles Leach Forest & Parks Bldg Dwight Clark Thoreau Butterfield Mahar Auditorium AVENUE GOVERNORS DRIVE STO C K B R ID GE ROAD CLARK HILL RD EASTPLEASANTSTREET FEARING STREET

Massachusetts at Amherst, University of

86

Contrib. Plasma Phys. 26 (1986) 1, 1-12 Sudden Jumps, Hysteresis, and Negative Resistance  

E-Print Network [OSTI]

are found in glow discharges, carbon arcs, thermionic converters, fluorescent lamps and four-layer diodes [lContrib. Plasma Phys. 26 (1986) 1, 1-12 Sudden Jumps, Hysteresis, and Negative Resistance in an Argon Plasma Discharge I. Discharges with No Magnetic Field R. A. BOSCHand R. L. MERLINO Department

Merlino, Robert L.

87

Jumping solitary waves in an autonomous reactiondiffusion system with subcritical wave instability  

E-Print Network [OSTI]

Jumping solitary waves in an autonomous reaction­diffusion system with subcritical wave instability as solutions to a reaction­diffusion system with a subcritical short-wavelength instability. We demonstrate systems with a subcritical oscillatory instability.17 Here we present a new type of solitary traveling

Epstein, Irving R.

88

Muscle performance during frog jumping: influence of elasticity on muscle operating lengths  

Science Journals Connector (OSTI)

...BF00711916 ) Askew, G. , and R. Marsh 1998 Optimal shortening velocity...1152/japplphysiol.01045.2004 ) Marsh, R. L. 1994 Jumping ability of anuran...Sci. Comp. Med. 38B, 51-111. Marsh, R. L. , and H. B. John-Alder...

2010-01-01T23:59:59.000Z

89

Evidence for a vertebrate catapult: elastic energy storage in the plantaris tendon during frog jumping  

Science Journals Connector (OSTI)

...8278808 ) 2 Roberts, T. J. , and R. L. Marsh 2003 Probing the limits to muscle-powered...00452 ) 3 Peplowski, M. M. , and R. L. Marsh 1997 Work and power output in the...Exp. Biol. 200, 2861-2870. 4 Marsh, R. L. 1994 Jumping ability of anuran...

2012-01-01T23:59:59.000Z

90

Educated and Equipped: Jump-Start Your Career in the Bioenergy Industry  

Office of Energy Efficiency and Renewable Energy (EERE)

Are you a recent college graduate looking to jump-start your career? Whether you majored in engineering or English, science or political science, business or biology, there are numerous opportunities to use your skills and education in the emerging bioenergy industry.

91

Rank Tests for the Observability of Discrete-Time Jump Linear Systems with Inputs  

E-Print Network [OSTI]

Rank Tests for the Observability of Discrete-Time Jump Linear Systems with Inputs Ehsan Elhamifar of rank tests on the parameters of the JLS when the discrete state sequence is arbitrary. Our key verify observ- ability by checking a number of rank tests that is only quadratic in the number

92

Jump conditions and dynamic surface tension at permeable interfaces such as the inner core boundary  

E-Print Network [OSTI]

Jump conditions and dynamic surface tension at permeable interfaces such as the inner core boundary as the density and viscosity changes. Independently of any intrinsic surface tension, a dynamic surface tension, a possibly anisotropic surface tension and terms including an interface mass density. In pratice

93

May 31, 2007 ON THE TRIPLE JUMP OF THE SET OF ATOMS OF A  

E-Print Network [OSTI]

May 31, 2007 ON THE TRIPLE JUMP OF THE SET OF ATOMS OF A BOOLEAN ALGEBRA. ANTONIO MONTALB´AN Abstract. We prove the following result about the degree spectrum of the atom relation on a computable Boolean algebra. Let C be a computable Boolean algebra with infinitely many atoms and a be the Turing

Montalbán, Antonio

94

Seismic signals are crucial for male mating success in a visual specialist jumping spider (Araneae: Salticidae)  

E-Print Network [OSTI]

Seismic signals are crucial for male mating success in a visual specialist jumping spider (Araneae of multicomponent seismic courtship signals in addition to and produced in concert with its multiple visual ornaments and movement displays. Here, we demonstrate the importance of these seismic signals

Hoy, Ronald R.

95

Jump conditions for unsteady small perturbations at fluid-solid interfaces in the  

E-Print Network [OSTI]

are validated with exact conditions derived from a direct linearization of the standard jump conditions. For a straightforward comparison between both approaches, all conditions are writ- ten in terms of a curvilinear (turbomachinery com- ponents, heat exchangers, jet pumps, nuclear reactors,...) and fluid-filled cav- ities

Paris-Sud XI, Université de

96

Vorticity Generation in the Shallow-Water Equations as Applied to Hydraulic Jumps  

Science Journals Connector (OSTI)

The authors attempt to find a bridge between the vorticity dynamics of a finite cross-stream length hydraulic jump implied by the Navier-Stokes equations and that given by the shallow-water approximation (SWA) with the turbulence of the hydraulic ...

Richard Rotunno; Piotr K. Smolarkiewicz

1995-02-01T23:59:59.000Z

97

Brief paper: Risk-sensitive filtering for jump Markov linear systems  

Science Journals Connector (OSTI)

In this paper, a risk-sensitive multiple-model filtering algorithm is derived using the reference probability methods. First, the approximation of the interacting multiple-model (IMM) algorithm is identified in the reference probability domain. Then, ... Keywords: IMM, Jump Markov linear system, Multiple-model estimation, Risk-sensitive estimation

Umut Orguner; Mbeccel Demirekler

2008-01-01T23:59:59.000Z

98

Enhancing single-molecule photostability by optical feedback from quantum jump detection  

E-Print Network [OSTI]

Enhancing single-molecule photostability by optical feedback from quantum jump detection V. Jacques; published online 20 November 2008 We report an optical technique that yields an enhancement of single-molecule and will allow the investigation of new phenomena at the single-molecule level. © 2008 American Institute

Murray, John D.

99

Kinetics and Mechanisms of Sulfate Adsorption/Desorption on Goethite Using Pressure-Jump Relaxation  

E-Print Network [OSTI]

Kinetics and Mechanisms of Sulfate Adsorption/Desorption on Goethite Using Pressure-Jump Relaxation Peng Chu Zhang* and Donald L. Sparks ABSTRACT Sulfate adsorption/desorption on goethite (Fe indicated that adsorption decreased with increased pH of the goethite suspension. The triple-layer model fit

Sparks, Donald L.

100

Simple Heuristic Derivation of the Universal Jump in the Superfluid Density of 2-Dimensional Superfluids  

E-Print Network [OSTI]

A simple heuristic derivation is given for the universal jump in the superfluid density rho(s) at the transition temperature T(c) of a two-dimensional superfluid. It is based on the mathematical equivalence of the Hamiltonians of two systems: (i) a...

Hu, Chia-Ren.

1992-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

DOE/EIS-0265-SA-167: Supplement Analysis for the Watershed Program EIS - Klickitat Watershed Enhancement Project - Klickitat Meadows Restoration (08/09/04)  

Broader source: Energy.gov (indexed) [DOE]

9, 2004 9, 2004 REPLY TO ATTN OF: KEC-4 SUBJECT: Supplement Analysis for the Watershed Management Program EIS (DOE/EIS-0265/SA-167) David Byrnes Fish and Wildlife Project Manager - KEWL-4 Proposed Action: Klickitat Watershed Enhancement Project - Klickitat Meadows Restoration Project No: 1997-056-00 Watershed Management Techniques or Actions Addressed Under This Supplement Analysis (See App. A of the Watershed Management Program EIS): 1.5 Install Grade Control Structures and Check Dams, 1.6 Install Large Woody Debris Structures, 1.8 Bank Protection through Vegetation Management, 1.9 Structural Bank Protection Using Bioengineering Methods, 1.17 Rearing Habitat Enhancements, 2.1 Maintain Healthy Riparian Plant Communities, 7.18 Road Closures, 8.10 Stream Channel Protection

102

Multistage jet deflection on ski jumps with flow-energy dissipation by compression of the entrained air  

Science Journals Connector (OSTI)

1. As flow is deflected along a ski-jump profile, a hydrodymamic pressure is developed which exceeds that of gra...

P. R. Khlopenkov

1977-07-01T23:59:59.000Z

103

Microsoft Word - S05993_CY2009 Annual Rpt.doc  

Office of Legacy Management (LM)

6 6 and sample points), vegetation community classifications, Preble's meadow jumping mouse habitat, wetland locations, wildfire/prescribed burn locations, Preble's meadow jumping mouse and wetland mitigation work, and rare plant locations. These data are available in various ArcGIS ® compatible formats. In addition to these types of spatial data, orthorectified aerial and satellite imagery is also available for the Site for different time frames, including pre- and post-closure. 3.4 Validation and Data Quality Assessment Data validation and verification (V&V) during CY 2009 was performed by Legacy Management Support contractor personnel at the Grand Junction, Colorado, office. Data quality assessment (DQA) is performed by personnel at the Site. The following section distinguishes DQA from

104

Mouse 2.0: Multi-touch Meets the Mouse Nicolas Villar1  

E-Print Network [OSTI]

by Doug Englebart et al. [9]. Since then, re- peated efforts have been made to augment the basic mouse

Benko, Hrvoje

105

Generation of high charge state ions in vacuum arc ion sources by a ``current jump'' method  

SciTech Connect (OSTI)

In the investigation of ion charge state distributions (CSD) in vacuum arc plasmas, good correlation between increase in arc operating voltage and mean ion charge state has been established. Therefore, to increase the mean charge state of a vacuum arc plasma, it is necessary to find ways to increase the arc operating voltage. The voltage can be increased via transients associated with the arc current by means of which a rather high operation voltage can be established across the discharge gap. Experiments were performed both in Tomsk and Berkeley with the discharge system of a vacuum arc ion source. To effect a step current rise an additional power supply was connected to the usual vacuum arc supply. This power supply made it possible to increase the vacuum arc current up to 1 kA for several {micro}s. As a rule the current jump was produced after 100--200 {micro}s into the main discharge pulse when all principal parameters of the vacuum arc were already established. To measure the CSD a time-of-flight method was used. As followed from experiments, superposition of a short, high current pulse to the vacuum arc current pulse is accompanied by a jump in arc operation voltage. Subsequently during the current step the voltage falls exponentially to one hundred volts after the completion of the current jump, and the arc voltage takes its conventional value (20--40V). Because of this increase in arc operation voltage, an enhancement of high charge station ion fractions was observed. For example, with a Ti-cathode with conventional arc parameters there is only very small value to Ti{sup 4+} ion fraction in the vacuum arc plasma. Applying strong magnetic field increases the fraction of these ions up to 20% of the total beam current. The current jump enhanced this value up to 40%.

Bugaev, A.S.; Oks, E.M.; Yushkov, G.Y.; Brown, I.G.

1999-07-01T23:59:59.000Z

106

The dissipated energy of electrode surfaces: Temperature jumps from coupled transport processes  

SciTech Connect (OSTI)

Nonequilibrium thermodynamics for surfaces has been applied to the electrode surfaces of an electrochemical cell. It is shown that the temperature of the surface differs from that of the adjacent electrolyte and electrode, and that a temperature jump exists across the surface. mathematical expressions are derived for the temperature profiles of two cells at steady-state conditions. Methods for estimating transport coefficients for the coupled transport processes at the electrode surface are discussed. Possible numerical results for the temperature profile, the overpotential, and the dissipated energy are reported. The results reflect the relative importance of heat conductivities, electric conductivities, and the Peltier coefficients for the electrode surface phenomena in combination with bulk properties. Significant temperature jumps may occur at normal electrolysis conditions 10{sup 3} to 10{sup 4} A/m, and for temperature jump coefficients which are smaller than 10{sup 3} J/s K{sup 2} m{sup 2}. The overpotential may have contributions from the Peltier coefficients for the surface larger than the ohmic contribution. The method of analysis gives new information useful for heat control of electrochemical cells, electrode kinetic studies, and interpretation of overpotentials.

Bedeaux, D. [Univ. of Leiden (Netherlands). Dept. of Physical and Macromolecular Chemistry; Ratkje, S.K. [Univ. of Trondheim (Norway)

1996-03-01T23:59:59.000Z

107

Mouse Models of Gynecologic Pathology  

Science Journals Connector (OSTI)

Over the past two decades, the cataloguing of mutated oncogenes and tumor-suppressor genes in various types of human cancers has provided a rich knowledge base for the creation of genetic models. Although powerful in terms of their ability to elucidate gene function in a controlled environment in... Two new mouse models have been devised that shed light on the genesis of endometriosis and endometrioid ovarian cancer, suggest drugs for the treatment of endometrioid ovarian cancer, and provide a means of testing them.

Boyd J.

2005-05-26T23:59:59.000Z

108

Quantum Jump Approach to Switching Process of a Josephson Junction Coupled to a Microscopic Two-Level System  

E-Print Network [OSTI]

With microwave irradiation, the switching current of a Josephson junction coupled to a microscopic two-level system jumps randomly between two discrete states. We modeled the switching process of the coupled system with quantum jump approach that was generally used in quantum optics. The parameters that affect the character of the quantum jumps between macroscopic quantum states are discussed. The results obtained from our theoretical analysis agree well with those of the experiments and provide a clear physical picture for the macroscopic quantum jumps in Josephson junctions coupled with two-level systems. In addition, quantum jumps may serve as a useful tool to investigate the microscopic two-level structures in solid-state systems.

Xueda Wen; Yiwen Wang; Ning Dong; Guozhu Sun; Jian Chen; Lin Kang; Weiwei Xu; Peiheng Wu; Yang Yu

2009-07-14T23:59:59.000Z

109

Characterization of the Mouse Brain Proteome Using Global Proteomic...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the Mouse Brain Proteome Using Global Proteomic Analysis Complemented with Cysteinyl-Peptide Enrichment. Characterization of the Mouse Brain Proteome Using Global Proteomic...

110

A cinematographical analysis of the action of the lead leg in the flop high jump  

E-Print Network [OSTI]

-knee trial 49 52 63 64 67 68 73 75 CHAPTER I INTRODUCTION The gold medal performance at the 1968 Olympic Games by Dick Fosbury of 2. 24 m introduced the flop high jump to the world. Named for it's innovator, the Fosbury flop is characterized by a... high jumpers for the Elite Athlete program co- sponsored by the United States Olympic Committee and The Athletics Congress. Filming took place at the 1983 Houston Invitational and the 1983 Athletics Congress Championships in Indianapolis. Two high...

Smith, Carol J

2012-06-07T23:59:59.000Z

111

Initial sequencing and comparative analysis of the mouse genome  

E-Print Network [OSTI]

Initial sequencing and comparative analysis of the mouse genome Mouse Genome Sequencing Consortium ........................................................................................................................................................................................................................... The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial

Eddy, Sean

112

Effect of wind and altitude on record performance in foot races, pole vault, and long jump  

Science Journals Connector (OSTI)

Using only elementary physics one can estimate the effect of wind and altitude on performance in several track and field events. Experiments have shown that the power lost to aerodynamicdrag forces is about a tenth of the total power expended in running at sprint speeds. From this observation one can calculate the effect of wind or of air density changes on sprinting speed. In pole vaulting the sprinter converts his kinetic energy into potential energy to clear the bar. In long jumping he is a projectile but he is prevented from reaching his optimum distance expected for his initial velocity by the height which he can attain during his jump. For each of these events performance in moderate winds of 2.0 m/s or at altitudes comparable to Mexico City differ by several percent from performances at sea level or in still air. In longer running races and in bicycle races aerodynamic forces play an important role in racing strategy. However since the athletes perform in groups it is difficult to calculate the effect on individual performances.

Cliff Frohlich

1985-01-01T23:59:59.000Z

113

Transit time instabilities in an inverted fireball. II. Mode jumping and nonlinearities  

SciTech Connect (OSTI)

A fireball is formed inside a highly transparent spherical grid immersed in a dc discharge plasma. The ambient plasma acts as a cathode and the positively biased grid as an anode. A strong nearly current-free double layer separates the two plasmas. Electrons are accelerated into the fireball, ionize, and establish a discharge plasma with plasma potential near the grid potential. Ions are ejected from the fireball. Since electrons are lost at the same rate as ions, most electrons accelerated into the fireball just pass through it. Thus, the electron distribution contains radially counterstreaming electrons. High-frequency oscillations are excited with rf period given by the electron transit time through the fireball. Since the frequency is well below the electron plasma frequency, no eigenmodes other than a beam space-charge wave exists. The instability is an inertial transit-time instability similar to the sheath-plasma instability or the reflex vircator instability. In contrast to vircators, there is no electron reflection from a space-charge layer but counterstreaming arises from spherical convergence and divergence of electrons. While the basic instability properties have been presented in a companion paper [R. L. Stenzel et al., Phys. Plasmas 18, 012104 (2011)], the present paper focuses on observed mode jumping and nonlinear effects. The former produce frequency jumps and different potential profiles, the latter produce harmonics associated with electron bunching at large amplitudes. In situ probe measurements are presented and interpreted.

Stenzel, R. L. [Department of Physics and Astronomy, University of California, Los Angeles, California 90095-1547 (United States); Gruenwald, J.; Fonda, B.; Ionita, C.; Schrittwieser, R. [Institute for Ion Physics and Applied Physics, Leopold-Franzens University of Innsbruck, Technikerstr. 25, A-6020 Innsbruck (Austria)

2011-01-15T23:59:59.000Z

114

The jump-off velocity of an impulsively loaded spherical shell  

SciTech Connect (OSTI)

We consider a constant temperature spherical shell of isotropic, homogeneous, linearly elastic material with density {rho} and Lame coefficients {lambda} and {mu}. The inner and outer radii of the shell are r{sub i} and r{sub o}, respectively. We assume that the inside of the shell is a void. On the outside of the shell, we apply a uniform, time-varying pressure p(t). We also assume that the shell is initially at rest. We want to compute the jump-off time and velocity of the pressure wave, which are the first time after t = 0 at which the pressure wave from the outer surface reaches the inner surface. This analysis computes the jump-off velocity and time for both compressible and incompressible materials. This differs substantially from [3], where only incompressible materials are considered. We will consider the behavior of an impulsively loaded, exponentially decaying pressure wave p(t) = P{sub 0{sup e}}{sup -{alpha}t}, where {alpha} {ge} 0. We notice that a constant pressure wave P(t) = P{sub 0} is a special case ({alpha} = 0) of a decaying pressure wave. Both of these boundary conditions are considered in [3].

Chabaud, Brandon M. [Los Alamos National Laboratory; Brock, Jerry S. [Los Alamos National Laboratory

2012-04-13T23:59:59.000Z

115

A Hidden Markov Model of atomic quantum jump dynamics in an optically probed cavity  

E-Print Network [OSTI]

We analyze the quantum jumps of an atom interacting with a cavity field. The strong atom- field interaction makes the cavity transmission depend on the time dependent atomic state, and we present a Hidden Markov Model description of the atomic state dynamics which is conditioned in a Bayesian manner on the detected signal. We suggest that small variations in the observed signal may be due to spatial motion of the atom within the cavity, and we represent the atomic system by a number of hidden states to account for both the small variations and the internal state jump dynamics. In our theory, the atomic state is determined in a Bayesian manner from the measurement data, and we present an iterative protocol, which determines both the atomic state and the model parameters. As a new element in the treatment of observed quantum systems, we employ a Bayesian approach that conditions the atomic state at time t on the data acquired both before and after t and we show that the state assignment by this approach is more decisive than the usual conditional quantum states, based on only earlier measurement data.

S. Gammelmark; W. Alt; T. Kampschulte; D. Meschede; K. Molmer

2014-05-02T23:59:59.000Z

116

X-Ray cavities and temperature jumps in strong cool core cluster Abell 2390  

E-Print Network [OSTI]

We present results based on the systematic analysis of high resolution 95\\,ks \\textit{Chandra} observations of the strong cool core cluster Abell 2390 at the redshift of z = 0.228, which hosts an energetic radio AGN. This analysis has enabled us to investigate five X-ray deficient cavities in the hot atmosphere of Abell 2390 within central 30\\arcsec, three of which are newly detected. Presence of these cavities have been confirmed through a various image processing techniques like, the surface brightness profiles, unsharp masked image, as well as 2D elliptical model subtracted residual map. Temperature profile as well as 2D temperature map revealed structures in the distribution of ICM, in the sense that ICM in NW direction is relatively cooler than that on the SE direction. Two temperature jumps, one from 6\\,keV to 9.25\\,keV at 72 kpc on the north direction, and the other from 6\\,keV to 10.27\\,keV at 108 kpc in the east direction have been observed. These temperature jumps are associated with the shocks with...

Sonkamble, S S; Pawar, P K; Patil, M K

2014-01-01T23:59:59.000Z

117

A parametric study of shock jump chemistry, electron temperature, and radiative heat transfer models in hypersonic flows  

E-Print Network [OSTI]

A PARAMETRIC STUDY OF SHOCK JUMP CHEMISTRY, ELECTRON TEMPERATURE, AND RADIATIVE HEAT TRANSFER MODELS IN HYPERSONIC FLOWS A Thesis by ROBERT BRIAN GREENDYKE Submitted to the Graduate College of Texas A&M University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE August 1988 Major Subject: Aerospace Engineering A PARAMETRIC STUDY OF SHOCK JUMP CHEMISTRY, ELECTRON TEMPERATURE, AND RADIATIVE HEAT TRANSFER MODELS IN HYPERSONIC FLOWS A Thesis by ROBERT BRIAN...

Greendyke, Robert Brian

2012-06-07T23:59:59.000Z

118

Dazl regulates mouse embryonic germ cell development  

E-Print Network [OSTI]

In the mouse, germ cells can undergo differentiation to become either oocytes or spermatozoa in response to sex of their gonadal environment. The nature of the germ cell-intrinsic aspects of this signaling have not been ...

Gill, Mark E

2010-01-01T23:59:59.000Z

119

AN XXY MALE IN THE MOUSE  

Science Journals Connector (OSTI)

...RUSSELL AND ERNEST H. Y. CHU BIOLOGY DIVISION, OAK RIDGE NATIONAL LABORATORY,* OAK RIDGE, TENNESSEE Communicated by Alexander Hollaender...exceptional male is illustrated in Figure 1. Other workers have not definitely identified the Y in the mouse...

Liane Brauch Russell; Ernest H. Y. Chu

1961-01-01T23:59:59.000Z

120

Questions and Answers - If you jumped into a pool of liquid oxygen, would  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Is there anything colderthan liquid nitrogen? Is there anything colder<br>than liquid nitrogen? Previous Question (Is there anything colder than liquid nitrogen?) Questions and Answers Main Index Next Question (What's the melting point of steel?) What's the melting point of steel? If you jumped into a pool of liquid oxygen, would your body instantly crystallize? Nothing happens instantly. The first thing would be frostbite to the skin followed by the onset of hypothermia to the internal organs. No doubt everything would "freeze up" with time. What this really brings up though is safety issues with cryogenic fluids, that is, those substances that are normally gases (like oxygen, nitrogen, carbon dioxide, hydrogen, or helium) at room temperature but can be changed to liquid form through the use of

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Reversible jump Markov chain Monte Carlo computation and Bayesian model determination  

E-Print Network [OSTI]

Markov chain Monte Carlo methods for Bayesian computation have until recently been restricted to problems where the joint distribution of all variables has a density with respect to some xed standard underlying measure. They have therefore not been available for application to Bayesian model determination, where the dimensionality of the parameter vector is typically not xed. This article proposes a new framework for the construction of reversible Markov chain samplers that jump between parameter subspaces of di ering dimensionality, which is exible and entirely constructive. It should therefore have wide applicability in model determination problems. The methodology is illustrated with applications to multiple change-point analysis in one and two dimensions, and toaBayesian comparison of binomial experiments.

Peter J. Green

1995-01-01T23:59:59.000Z

122

Decoherent time-dependent transport beyond Landauer-Bttiker: a Quantum Drift alternative to Quantum Jumps  

E-Print Network [OSTI]

We present a model for decoherence in time-dependent transport. It boils down into a form of wave function that undergoes a smooth stochastic drift of the phase in a local basis, the Quantum Drift (QD) model. This drift is nothing else but a local energy fluctuation. Unlike Quantum Jumps (QJ) models, no jumps are present in the density as the evolution is unitary. As a first application, we address the transport through a resonant state $\\left\\vert 0\\right\\rangle $ that undergoes decoherence. We show the equivalence with the decoherent steady state transport in presence of a B\\"{u}ttiker's voltage probe. In order to test the dynamics, we consider two many-spin systems whith a local energy fluctuation. A two-spin system is reduced to a two level system (TLS) that oscillates among $\\left\\vert 0\\right\\rangle $ $\\equiv $ $ \\left\\vert \\uparrow \\downarrow \\right\\rangle $ and $\\left\\vert 1\\right\\rangle \\equiv $ $\\left\\vert \\downarrow \\uparrow \\right\\rangle $. We show that QD model recovers not only the exponential damping of the oscillations in the low perturbation regime, but also the non-trivial bifurcation of the damping rates at a critical point, i.e. the quantum dynamical phase transition. We also address the spin-wave like dynamics of local polarization in a spin chain. The QD average solution has about half the dispersion respect to the mean dynamics than QJ. By evaluating the Loschmidt Echo (LE), we find that the pure states $\\left\\vert 0\\right\\rangle $ and $\\left\\vert 1\\right \\rangle $ are quite robust against the local decoherence. In contrast, the LE, and hence coherence, decays faster when the system is in a superposition state. Because its simple implementation, the method is well suited to assess decoherent transport problems as well as to include decoherence in both one-body and many-body dynamics.

Lucas J. Fernndez-Alczar; Horacio M. Pastawski

2015-01-26T23:59:59.000Z

123

Surfing the internet with a BCI mouse  

Science Journals Connector (OSTI)

In this paper, we present a new web browser based on a two-dimensional (2D) braincomputer interface (BCI) mouse, where our major concern is the selection of an intended target in a multi-target web page. A real-world web page may contain tens or even hundreds of targets, including hyperlinks, input elements, buttons, etc. In this case, a target filter designed in our system can be used to exclude most of those targets of no interest. Specifically, the user filters the targets of no interest out by inputting keywords with a P300-based speller, while keeps those containing the keywords. Such filtering largely facilitates the target selection task based on our BCI mouse. When there are only several targets in a web page (either an original sparse page or a target-filtered page), the user moves the mouse toward the target of interest using his/her electroencephalographic signal. The horizontal movement and vertical movement are controlled by motor imagery and P300 potential, respectively. If the mouse encounters a target of no interest, the user rejects it and continues to move the mouse. Otherwise the user selects the target and activates it. With the collaboration of the target filtering and a series of mouse movements and target selections/rejections, the user can select an intended target in a web page. Based on our browser system, common navigation functions, including history rolling forward and backward, hyperlink selection, page scrolling, text input, etc, are available. The system has been tested on seven subjects. Experimental results not only validated the efficacy of the proposed method, but also showed that free internet surfing with a BCI mouse is feasible.

Tianyou Yu; Yuanqing Li; Jinyi Long; Zhenghui Gu

2012-01-01T23:59:59.000Z

124

Distributed Bayesian fault diagnosis of jump Markov systems in wireless sensor networks  

Science Journals Connector (OSTI)

A Bayesian distributed online change detection algorithm is proposed for monitoring a dynamical system by a wireless sensor network. The proposed solution relies on modelling the system dynamics by a jump Markov system with a finite set of states, including the abrupt change behaviour. For each discrete state, an observed system is assumed to evolve according to a state-space model. The collaborative strategy ensures the efficiency and the robustness of the data processing, while limiting the required communications bandwith. An efficient Rao-Blackwellised Collaborative Particle Filter (RB-CPF) is proposed to estimate the a posteriori probability of the discrete states of the observed systems. The Rao-Blackwellisation procedure combines a Sequential Monte-Carlo (SMC) filter with a bank of distributed Kalman filters. In order to prolong the sensor network lifetime, only few active (leader) nodes are selected according to a spatio-temporal selection protocol. This protocol is based on a trade-off between error propagation, communications constraints and information content complementarity of distributed data. Only sufficient statistics are communicated between leader nodes and their collaborators.

Hichem Snoussi; Cedric Richard

2007-01-01T23:59:59.000Z

125

Construction of Anatomically Correct Models of Mouse Brain Networks 1  

E-Print Network [OSTI]

Construction of Anatomically Correct Models of Mouse Brain Networks 1 B. H. McCormick a, W. Koh a Y and Public Health, Texas A&M University, 4458 TAMU, College Station, TX 77843-4458 Abstract The Mouse Brain Web, a federated database, provides for the construction of anatomically correct models of mouse brain

Choe, Yoonsuck

126

Where Did All the Money Go? Congress approved the Troubled Asset Relief Program (TARP) to jump start the credit  

E-Print Network [OSTI]

Where Did All the Money Go? Congress approved the Troubled Asset Relief Program (TARP) to jump forward that unfortunately remains vague. Inexplicably, the TARP II money did not come with a mandate to use the money to increase lending. Now, covenants come with the distribution of the remaining TARP

Ahmad, Sajjad

127

Effect of shockwave-induced density jump on laser plasma interactions in low-pressure ambient air  

E-Print Network [OSTI]

and Aerospace Engineering and the Center for Energy Research, University of California San Diego, 9500 Gilman significantly reduce laser energy absorbed in the solid plasma. The ionization of the density jump was confirmed , extreme ultraviolet lithography (EUVL) source 3 , and inertial fusion energy (IFE) 4 . During

Tillack, Mark

128

A Numerical Method for Pricing Electricity Derivatives for Jump-Diffusion Processes Based on Continuous Time Lattices  

E-Print Network [OSTI]

A Numerical Method for Pricing Electricity Derivatives for Jump-Diffusion Processes Based.tompaidis@mccombs.utexas.edu Corresponding author. Tel. 512-4715252, Fax 512-4710587. #12;A Numerical Method for Pricing Electricity method for pricing derivatives on electricity prices. The method is based on approximating the generator

Albanese, Claudio

129

Steel characteristics measurement system using Barkhausen jump sum rate and magnetic field intensity and method of using same  

DOE Patents [OSTI]

A steel hardness measurement system and method of using same are provided for measuring at least one mechanical or magnetic characteristic of a ferromagnetic sample as a function of at least one magnetic characteristic of the sample. A magnetic field generator subjects the sample to a variable external magnetic field. The magnetic field intensity of the magnetic field generated by the magnetic field generating means is measured and a signal sensor is provided for measuring Barkhausen signals from the sample when the sample is subjected to the external magnetic field. A signal processing unit calculates a jump sum rate first moment as a function of the Barkhausen signals measured by the signal sensor and the magnetic field intensity, and for determining the at least one mechanical or magnetic characteristic as a function of the jump sum rate first moment. 7 figs.

Kohn, G.; Hicho, G.; Swartzendruber, L.

1997-04-08T23:59:59.000Z

130

"Granular jets and hydraulic jumps on an inclined plane", C. G. Johnson, J. M. N. T. Gray ( ), J. Fluid Mech., (Submitted)  

E-Print Network [OSTI]

indicates the parameters for which teardrop-shaped shocks (?), blunted shocks (), steady subcritical , with supercritical ow (Fr > 1) marked in red/yellow, and subcritical ow (Fr a discontinuity in ow height and velocity, analogous to a hydraulic jump in shallow-water ow. is steady jump takes

Heil, Matthias

131

Algorithms and hardness results for the jump number problem, the joint replenishment problem, and the optimal clustering of frequency-constrained maintenance jobs  

E-Print Network [OSTI]

In the first part of this thesis we present a new, geometric interpretation of the jump number problem on 2-dimensional 2-colorable (2D2C) partial order. We show that the jump number of a 2D2C poset is equivalent to the ...

Telha Cornejo, Claudio (Claudio A.)

2012-01-01T23:59:59.000Z

132

Vestas USA | Open Energy Information  

Open Energy Info (EERE)

Vestas USA Jump to: navigation, search Name: Vestas USA Place: Rolling Meadows, Illinois Zip: IL 60008-4030 Sector: Wind energy Product: Vestas Wind Systems American arm....

133

Neutron issues in the JANUS mouse program  

SciTech Connect (OSTI)

Over the last 25 years, the JANUS program in the Biological and Medical Research Division at Argonne National Laboratory (ANL) has compiled a database on the response of both sexes of an F{sub 1} hybrid mouse, the B6CF{sub 1} (C57BL/6 x BALB/c), to external whole- body irradiation by {sup 60}Co {gamma}-rays and fission neutrons. Three basic patterns of exposure for both neutrons and {gamma}-rays have been investigated: single exposures, 24 equal once-weekly exposures, and 60 equal once-weekly exposures. All irradiations were terminated at predetermined total doses, with dose calculated in centigrays at the midline of the mouse. Three endpoints will be discussed in this paper: (1) life shortening, (2) a point estimate for cumulative mortality, and (3) the hazard function. Life shortening is used as an analysis endpoint because it summarizes, in a single index, the integrated effect of all injuries accumulated by an organism. Histopathological analyses of the mice used in the ANL studies have indicated that 85% of the deaths were caused by neoplasms. Connective tissue tumors were the dominant tumor in the B6CF{sub 1} mouse, with tumors of lymphoreticular origin accounting for approximately 80% of this class. The latter two endpoints will therefore be used to describe the life table experience of mice dying from the lymphoreticular class of tumors. Dose-response models will be applied to the three endpoints in order to describe the response function for neutron exposures, evaluate the effect of dose range and pattern of exposure on the response function for neutrons, and provide a set of neutron relative biological effectiveness (RBE) values of the ANL database. 25 refs.

Carnes, B.A.; Grahn, D.

1990-01-01T23:59:59.000Z

134

Spatial Mapping of Protein Abundances in the Mouse Brain by Voxelation...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mapping of Protein Abundances in the Mouse Brain by Voxelation Integrated with High-Throughput Liquid Chromatography Spatial Mapping of Protein Abundances in the Mouse Brain by...

135

E-Print Network 3.0 - adult mouse white Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

mouse white Search Powered by Explorit Topic List Advanced Search Sample search results for: adult mouse white Page: << < 1 2 3 4 5 > >> 1 Boston University Computer Science...

136

E-Print Network 3.0 - adult transgenic mouse Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

mouse model engineered to investigate human brain-derived neurotrophic... transgenic lines have been obtained through microinjection of the YAC into fertilized mouse oocytes....

137

HumanMouse Gene Identification by Comparative Evidence Integration and  

E-Print Network [OSTI]

The identification of genes in the human genome remains a challenge, as the actual predictions appear to disagree of genes in the human genome by using a reference, such as mouse genome. However, this comparative genome. In particular, it is not clear whether the mouse is at the correct evolutionary distance from

Pavlovic, Vladimir

138

An Efficient Quantum Jump Method for Coherent Energy Transfer Dynamics in Photosynthetic Systems under the Influence of Laser Fields  

E-Print Network [OSTI]

We present a non-Markovian quantum jump approach for simulating coherent energy transfer dynamics in molecular systems in the presence of laser fields. By combining a coherent modified Redfield theory (CMRT) and a non-Markovian quantum jump (NMQJ) method, this new approach inherits the broad-range validity from the CMRT and highly efficient propagation from the NMQJ. To implement NMQJ propagation of CMRT, we show that the CMRT master equation can be casted into a generalized Lindblad form. Moreover, we extend the NMQJ approach to treat time-dependent Hamiltonian, enabling the description of excitonic systems under coherent laser fields. As a benchmark of the validity of this new method, we show that the CMRT-NMQJ method accurately describes the energy transfer dynamics in a prototypical photosynthetic complex. Finally, we apply this new approach to simulate the quantum dynamics of a dimer system coherently excited to coupled single-excitation states under the influence of laser fields, which allows us to investigate the interplay between the photoexcitation process and ultrafast energy transfer dynamics in the system. We demonstrate that laser-field parameters significantly affect coherence dynamics of photoexcitations in excitonic systems, which indicates that the photoexcitation process must be explicitly considered in order to properly describe photon-induced dynamics in photosynthetic systems. This work should provide a valuable tool for efficient simulations of coherent control of energy flow in photosynthetic systems and artificial optoelectronic materials.

Qing Ai; Yuan-Jia Fan; Bih-Yaw Jin; Yuan-Chung Cheng

2014-04-19T23:59:59.000Z

139

Laser-induced temperature jump/time-resolved infrared study of the fast events in protein folding  

SciTech Connect (OSTI)

Laser-induced temperature jump followed by time-resolved infrared probe of reaction dynamics are used to study the temporal evolution of polypeptide structure during protein folding and unfolding. Reactions are initiated in times of 50 ps or longer by T-jumps of 10`s of degrees, obtained by laser excitation of water overtone absorbances. Observation of the Amide I transient absorbances reveal melting lifetimes of helices unconstrained by tertiary structure to be ca. 160 ns in a model 21-peptide and ca. 30 ns in {open_quotes}molten globule{close_quotes} apomyoglobin. No other processes are observed in these systems over the timescale 50 ps to 2 ms. Equilibrium data suggest the corresponding helix formation lifetimes to be ca. 16 and 1 ns, respectively. In {open_quotes}native{close_quotes} apomyoglobin two helix melting lifetimes are observed and we infer that a third occurs on a timescale inaccessible to our experiment (> 1 ms). The shorter observed lifetime, as in the molten globule, is ca. 30 ns. The longer lifetime is ca. 70 {mu}s. We suggest that the slower process is helix melting that is rate-limited by the unfolding of tertiary structure. Equilibrium data suggest a lifetime of ca. 1 {mu}s for the development of these tertiary folds.

Woodruff, W.H.; Dyer, R.B.; Williams, S. [Los Alamos National Laboratory, NM (United States); Callender, H.; Gilmanshin, R. [CUNY, NY (United States)

1996-10-01T23:59:59.000Z

140

Probing the mechanism of rubredoxin thermal unfolding in the absence of salt bridges by temperature jump experiments  

SciTech Connect (OSTI)

Rubredoxins are the simplest type of iron-sulphur proteins and in recent years they have been used as model systems in protein folding and stability studies, especially the proteins from thermophilic sources. Here, we report our studies on the rubredoxin from the hyperthermophile Methanococcus jannaschii (T {sub opt} = 85 deg C), which was investigated in respect to its thermal unfolding kinetics by temperature jump experiments. Different spectroscopic probes were used to monitor distinct structural protein features during the thermal transition: the integrity of the iron-sulphur centre was monitored by visible absorption spectroscopy, whereas tertiary structure was followed by intrinsic tryptophan fluorescence and exposure of protein hydrophobic patches was sensed by 1-anilinonaphthalene-8-sulphonate fluorescence. The studies were performed at acidic pH conditions in which any stabilising contributions from salt bridges are annulled due to protonation of protein side chain groups. In these conditions, M. jannaschii rubredoxin assumes a native-like, albeit more flexible and open conformation, as indicated by a red shift in the tryptophan emission maximum and 1-anilinonaphthalene-8-sulphonate binding. Temperature jumps were monitored by the three distinct techniques and showed that the protein undergoes thermal denaturation via a simple two step mechanism, as loss of tertiary structure, hydrophobic collapse, and disintegration of the iron-sulphur centre are concomitant processes. The proposed mechanism is framed with the multiphasic one proposed for Pyrococcus furiosus rubredoxin, showing that a common thermal unfolding mechanism is not observed between these two closely related thermophilic rubredoxins.

Henriques, Barbara J. [Instituto Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras (Portugal); Saraiva, Ligia M. [Instituto Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras (Portugal); Gomes, Claudio M. [Instituto Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras (Portugal)]. E-mail: gomes@itqb.unl.pt

2005-08-05T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

COS DCE BOOT FSW v1.09 Component Test Results Requirement 5.2.4.1 Command to Jump Anywhere in Code  

E-Print Network [OSTI]

COS DCE BOOT FSW v1.09 Component Test Results Requirement 5.2.4.1 Command to Jump Anywhere in Code. Brownsberger 2-13-01 The Center for Astrophysics and Space Astronomy Reviewed: Approved: COS DCE BOOT FSW v1 Astronomy Initial Release COS DCE BOOT FSW v1.09 Component Test Results Requirement 5.2.4.1 Command to Jump

Colorado at Boulder, University of

142

COS DCE BOOT FSW v1.13 Component Test Results Requirement 5.2.4.1 Command to Jump Anywhere in Code  

E-Print Network [OSTI]

COS DCE BOOT FSW v1.13 Component Test Results Requirement 5.2.4.1 Command to Jump Anywhere in Code. Brownsberger 2-13-01 The Center for Astrophysics and Space Astronomy Reviewed: Approved: COS DCE BOOT FSW v1 Astronomy Initial Release COS DCE BOOT FSW v1.13 Component Test Results Requirement 5.2.4.1 Command to Jump

Colorado at Boulder, University of

143

Trb2, a mouse homolog of tribbles, is dispensable for kidney and mouse development  

SciTech Connect (OSTI)

Glomeruli comprise an important filtering apparatus in the kidney and are derived from the metanephric mesenchyme. A nuclear protein, Sall1, is expressed in this mesenchyme, and we previously reported that Trb2, a mouse homolog of Drosophila tribbles, is expressed in the mesenchyme-derived tissues of the kidney by microarray analyses using Sall1-GFP knock-in mice. In the present report, we detected Trb2 expression in a variety of organs during gestation, including the kidneys, mesonephros, testes, heart, eyes, thymus, blood vessels, muscle, bones, tongue, spinal cord, and ganglions. In the developing kidney, Trb2 signals were detected in podocytes and the prospective mesangium of the glomeruli, as well as in ureteric bud tips. However, Trb2 mutant mice did not display any apparent phenotypes and no proteinuria was observed, indicating normal glomerular functions. These results suggest that Trb2 plays minimal roles during kidney and mouse development.

Takasato, Minoru [Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811 (Japan); Department of Life Sciences (Biology), Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Kobayashi, Chiyoko [Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811 (Japan); Okabayashi, Koji [Department of Life Sciences (Biology), Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Kiyonari, Hiroshi; Oshima, Naoko [Laboratory for Animal Resources and Genetic Engineering, Center for Developmental Biology (CDB), RIKEN Kobe, 2-2-3 Minatojima Minami, Chuo-ku, Kobe 650-0047 (Japan); Asashima, Makoto [Department of Life Sciences (Biology), Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Nishinakamura, Ryuichi [Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811 (Japan)], E-mail: ryuichi@gpo.kumamoto-u.ac.jp

2008-09-05T23:59:59.000Z

144

Insights from Human/Mouse genome comparisons  

SciTech Connect (OSTI)

Large-scale public genomic sequencing efforts have provided a wealth of vertebrate sequence data poised to provide insights into mammalian biology. These include deep genomic sequence coverage of human, mouse, rat, zebrafish, and two pufferfish (Fugu rubripes and Tetraodon nigroviridis) (Aparicio et al. 2002; Lander et al. 2001; Venter et al. 2001; Waterston et al. 2002). In addition, a high-priority has been placed on determining the genomic sequence of chimpanzee, dog, cow, frog, and chicken (Boguski 2002). While only recently available, whole genome sequence data have provided the unique opportunity to globally compare complete genome contents. Furthermore, the shared evolutionary ancestry of vertebrate species has allowed the development of comparative genomic approaches to identify ancient conserved sequences with functionality. Accordingly, this review focuses on the initial comparison of available mammalian genomes and describes various insights derived from such analysis.

Pennacchio, Len A.

2003-03-30T23:59:59.000Z

145

Proteomic analysis of gliosomes from mouse brain: identification and investigation of glial membrane proteins  

Science Journals Connector (OSTI)

Proteomic analysis of gliosomes from mouse brain: identification and investigation of glial membrane proteins ...

Karen E. Carney; Marco Milanese; Pim van Nierop; Ka Wan Li; Stphane H.R. Oliet; August B. Smit; Giambattista Bonanno; Mark H.G. Verheijen

2014-10-13T23:59:59.000Z

146

Ethanol Promotes Intestinal Tumorigenesis in the MIN Mouse  

Science Journals Connector (OSTI)

...Washington, DC Abstract 2872: Effects of ethanol and folate on peripubertal mouse mammary...consumption. The proposed mechanisms whereby ethanol exerts its effects include decreased folate...proposed mechanisms, we hypothesized that ethanol would have increased deleterious effects...

Hemant K. Roy; James M. Gulizia; William J. Karolski; Anne Ratashak; Michael F. Sorrell; Dean Tuma

2002-11-01T23:59:59.000Z

147

End Sequencing and Finger Printing of Human & Mouse BAC Libraries  

SciTech Connect (OSTI)

This project provided for continued end sequencing of existing and new BAC libraries constructed to support human sequencing as well as to initiate BAC end sequencing from the mouse BAC libraries constructed to support mouse sequencing. The clones, the sequences, and the fingerprints are now an available resource for the community at large. Research and development of new metaodologies for BAC end sequencing have reduced costs and increase throughput.

Fraser, C.

2005-09-27T23:59:59.000Z

148

Low Dose Radiation Research Program: Identification of Mouse Genetic  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mouse Genetic Susceptibility to Radiation Carcinogenesis Mouse Genetic Susceptibility to Radiation Carcinogenesis Allan Balmain University of California, San Francisco San Francisco, CA. (Jointly funded by NASA and DOE) Why this Project? To identify pathways that control genetic susceptibility to radiation-induced DNA damage and tumor development using novel developments in genomics together with mouse genetics. Project Goals To identify genetic loci that trigger rapid tumor development of mice after radiation. To characterize new genes at these loci that act as tumor suppressor genes or oncogenes. Experimental Approach New candidate-radiation susceptibility genes will be identified using a unique haplotyping approach. Using DNA from radiation-induced lymphoma, changes in the gene copy number can be detected using BAC microarrays. The

149

E-Print Network 3.0 - aging mouse brain Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

mouse brain Search Powered by Explorit Topic List Advanced Search Sample search results for: aging mouse brain Page: << < 1 2 3 4 5 > >> 1 www.sciencemag.org SCIENCE VOL 313 29...

150

Tandem Mass Spectrometry identifies many mouse brain O-GlcNAcylated...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Tandem Mass Spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase Tandem Mass Spectrometry identifies many mouse brain...

151

E-Print Network 3.0 - atdc5 mouse progenitor Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

con- firmed for mouse brain glia... astrocytes and the other, oligodendro- cytes. Comparison of O-2A Progenitors from Rat Optic Nerve and Mouse... and co-workers reported that...

152

Model 923-B Mouse Gas Anesthesia Head Holder Adaptor Adjustment Features  

E-Print Network [OSTI]

Model 923-B Mouse Gas Anesthesia Head Holder Adaptor Adjustment Features Dorsal/Ventral dial.352.3139 Toll Free: 1.877.352.3275 ^^ci&ion Q)e&i^n^^^r ^esea/H^/i Model 923-B Mouse Gas Anesthesia Head Holder 923B-1/07 #12;MODEL 923-B MOUSE GAS ANESTHESIA HEAD HOLDER The KOPF Mouse Gas Anesthesia Head Holder

Kleinfeld, David

153

Systematic Enhancement of Polymerization of Recombinant Sickle Hemoglobin Mutants: Implications for Transgenic Mouse Model  

E-Print Network [OSTI]

for Transgenic Mouse Model for Sickle Cell Anemia By Xianfeng Li, Urooj A. Mirza, Brian T. Chait, and James M for sisting of HbS, Hb Antilles, and Hb D-Punjab. Normal mouse sickle cell anemia, we have expressed generation of the transgenic mouse model for sickle cell and polymerized in a linear manner at progressively

Chait, Brian T.

154

Zgoubi-ing AGS : spin motion with snakes and jump-quads,G? = 43.5 through G? = 46.5 and beyond  

SciTech Connect (OSTI)

This Note reports on the first, and successful, simulations of particle and spin dynamics in the AGS in presence of the two helical snakes and of the tune-jump quadrupoles, using the ray-tracing code Zgoubi. It includes DA tracking in the absence or in the presence of the two helical snakes, simulation of particle and spin motion in the snakes using their magnetic field maps, spin flipping at integer resonances in the 36+Qy depolarizing resonance region, with and without tune-jump quadrupole gymnastics. It also includes details on the setting-up of Zgoubi input data files and on the various numerical methods of concern in and available from Zgoubi.

Meot F.; Ahrens& #44; L.; Glenn& #44; J.; Huang& #44; H.; Luccio& #44; A.; MacKay& #44; W.W.; Roser& #44; T.; Tsoupas& #44; N.

2009-10-01T23:59:59.000Z

155

Private and Public Antigens of the Mouse H-2 System  

Science Journals Connector (OSTI)

... of the antisera against public antigens but only very few reacted with antisera against the private antigens4. It could still have been argued that because the sample of wild mice ... which are widely shared by the alleles of the laboratory mouse6. The second group-the private antigens-consists of antigens H-2.2, 4, 9, 17, 19, 23 ...

JAN KLEIN

1971-02-26T23:59:59.000Z

156

Spontaneous Metastasis from Primary C3H Mouse Mammary Tumors  

Science Journals Connector (OSTI)

...2 sublines of the C3H strain, the exogenous (milk transmit ted) mouse mammary tumor virus-infectedC3H/He and the aforemen...140-147, 1983. 20. Cam, Y., Caulet, T., Bellon, G., Poulin, G., Legros, M., and Pytlinska, M. Immunohistochemical...

Jan Vaage and James P. Harlos

1987-01-15T23:59:59.000Z

157

Cytochemical Studies on the Mouse Mammary Tumor Virus  

Science Journals Connector (OSTI)

...Elaboration in C3H Mouse Mammary Car cinoma as Observed by...and Bernhard, W. Water Soluble Embedding Media...Hydroxypropyl Methacrylate, a New Water-miscible Embedding Medium...Bernhard, W. The Use of Water-soluble Glycol Methacrylate...Smith FIG. 5. Low-power micrograph showing the...

Gilbert H. Smith

1967-11-01T23:59:59.000Z

158

Transplantable Mouse Neoplasm Control by Neutron Capture Therapy  

Science Journals Connector (OSTI)

... Elemental boron enriched to 96 per cent of boron-10 was converted to borax, and then to the more soluble sodium pentaborate. For injections ... intravenous injection in the mouse. Drug, sodium pentaborate decahydrate; dose, 35 mg as boron-10/g body weight. Each point represents an average obtained from ten animals. The analyses ...

LEE E. FARR; T. KONIKOWSKI

1967-07-29T23:59:59.000Z

159

Fundamental Ca2 Signaling Mechanisms in Mouse Dendritic  

E-Print Network [OSTI]

Fundamental Ca2 Signaling Mechanisms in Mouse Dendritic Cells: CRAC Is the Major Ca2 Entry Pathway, Meyer B. Jackson, David E. Clapham,* and Gerard P. Ahern2 Although Ca2 -signaling processes are thought to underlie many dendritic cell (DC) functions, the Ca2 entry pathways are unknown. Therefore, we investigated

Clapham, David E.

160

A small Handbook of Quantum Mechanics A. Nony Mous  

E-Print Network [OSTI]

A small Handbook of Quantum Mechanics A. Nony Mous "Seek simplicity and distrust it.". . . Alfred Spaces And All That 1.1 Introduction This handbook is meant to be a short introduction to Quantum of the mathematical formalism in a conceptual way. Among the major "discoveries" of physics in the twentieth century

Hart, Gus

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

A robust automated system elucidates mouse home cage behavioral structure  

E-Print Network [OSTI]

A robust automated system elucidates mouse home cage behavioral structure Evan H. Gouldinga,1 , A of behavior exhibited by mice in their home cages reflect the function and interaction of numerous behavioral of organization across diverse behaviors has been difficult to achieve and automate. Here, we describe

Jiggins, Francis

162

Structure and Emergence of Specific Olfactory Glomeruli in the Mouse  

E-Print Network [OSTI]

in the olfactory bulb. Connecting 1000 populations of OSNs to the 1800 glomeruli of the mouse bulb poses fluorescent protein (GFP) or a fusion of tau with GFP. We visualized OSNs and their axons in whole mounts-expressing OSNs occupies a large surface area of the bulb and coalesces abruptly into a proto- glomerulus

163

Mouse inbred strain differences in ethanol drinking to intoxication  

E-Print Network [OSTI]

Mouse inbred strain differences in ethanol drinking to intoxication J. S. Rhodes*, , M. M. Ford , C described a simple procedure, Drinking in the Dark (DID), in which C57BL/6J mice self-administer ethanol to a blood ethanol concentration (BEC) above 1 mg/ml. The test consists of replacing the water with 20

Garland Jr., Theodore

164

Mechanistic basis of infertility of mouse intersubspecific hybrids  

E-Print Network [OSTI]

Mechanistic basis of infertility of mouse intersubspecific hybrids Tanmoy Bhattacharyyaa , Sona to the Dobzhansky­Muller model, hybrid sterility is a consequence of the independent evolution of related taxa result- ing in incompatible genomic interactions of their hybrids. The model implies

Dean, Matthew D.

165

Microsoft Word - S08568_CY2011 Annual Rpt  

Office of Legacy Management (LM)

383 383 3.2 Ecological Monitoring 3.2.1 Introduction The Ecology group conducts ecological monitoring of the Site's ecological resources to ensure regulatory compliance and to preserve, protect, and manage those resources. Ecological monitoring is an integral aspect of determining whether the management objectives and goals for the natural resources at the Site are being achieved. This report summarizes the results of the ecological monitoring that was conducted at the Site during 2011. It includes a brief summary of the monitoring conducted for Preble's meadow jumping mouse (Zapus hudsonius preblei; Preble's mouse) mitigation and wetland mitigation activities; however, the details of those monitoring efforts are summarized in separate regulatory reports provided to the

166

KIRKWOOD MEADOWS PUBLIC UTILITY DISTRICT AGENDA REPORT  

E-Print Network [OSTI]

energy resources Enforcement Plan and Procurement Plan governing the procurement of a minimum quantity by the KMPUD pursuant to PUC § 399.30 Energy Commission: The State Energy Resources Conservation Discussion and Possible Action Approval of Resolution to Adopt the Renewable Portfolio Standard Enforcement

167

Lester Meadow Geothermal Area | Open Energy Information  

Open Energy Info (EERE)

Date: Well Name: Location: Depth: Initial Flow Rate: "ead" is not declared as a valid unit of measurement for this property. The given value was not understood. Flow Test...

168

Low Dose Radiation Research Program: Adaptive Response of Mouse Skin  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Adaptive Response of Mouse Skin Epithelial Cells to Low Dose Ionizing Radiation: Induction of NF-κB, MnSOD, 14-3-3ζ and Cyclin B1 Authors: Jian Jian Li, Kazi M. Ahmed, Ming Fan, Shaozhong Dong, Douglas R. Spitz, and Cheng-Rong Yu Institutions: Division of Molecular Radiobiology, Purdue University School of Health Sciences, West Lafayette, Indiana; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa; Molecular Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland Gene expression profiles demonstrate that a group of key stress-responsive genes are associated with radiation exposure and may contribute to cellular

169

An Anisotropic Fluid-Solid Model of the Mouse Heart  

SciTech Connect (OSTI)

A critical challenge in biomechanical simulations is the spatial discretization of complex fluid-solid geometries created from imaging. This is especially important when dealing with Lagrangian interfaces, as there must be at a minimum both geometric and topological compatibility between fluid and solid phases, with exact matching of the interfacial nodes being highly desirable. We have developed a solution to this problem and applied the approach to the creation of a 3D fluidsolid mesh of the mouse heart. First, a 50 micron isotropic MRI dataset of a perfusion-fixed mouse heart was segmented into blood, tissue, and background using a customized multimaterial connected fuzzy thresholding algorithm. Then, a multimaterial marching cubes algorithm was applied to produce two compatible isosurfaces, one for the blood-tissue boundary and one for the tissue-background boundary. A multimaterial smoothing algorithm that rigorously conserves volume for each phase simultaneously smoothed the isosurfaces. Next we applied novel automated meshing algorithms to generate anisotropic hybrid meshes with the number of layers and the desired element anisotropy for each material as the only input parameters. As the meshes are scale-invariant within a material and include boundary layer prisms, fluid-structure interaction computations would have a relative error equilibrated over the entire mesh. The resulting model is highly detailed mesh representation of the mouse heart, including features such as chordae and coronary vasculature, that is also maximally efficient to produce the best simulation results for the computational resources available

Carson, James P.; Kuprat, Andrew P.; Jiao, Xiangmin; del Pin, Facundo; Einstein, Daniel R.

2010-01-01T23:59:59.000Z

170

E-Print Network 3.0 - a140v mouse model Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Version 6. Official copy "Mouse" in Berkshire Encyclopedia of Human-Computer Interaction, W.S. Bainbridge (ed). 2004 by Berkshire Publishing Group. http:www.berkshirepublishing.c...

171

A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes  

Science Journals Connector (OSTI)

A mouse embryonic stem cell bank of inducible human chromosome 21 gene expression is shown to be an important resource for investigating trisomy.

Rossella De Cegli; Antonio Romito; Simona Iacobacci; Lei Mao; Mario Lauria; Anthony O Fedele; Joachim Klose; Christelle Borel; Patrick Descombes; Stylianos E Antonarakis; Diego di Bernardo; Sandro Banfi; Andrea Ballabio; Gilda Cobellis

2010-06-22T23:59:59.000Z

172

E-Print Network 3.0 - adult mouse tissues Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Shanghai Institute of Biological Sciences Collection: Biology and Medicine 25 A gene atlas of the mouse and human protein-encoding transcriptomes Summary: information on the...

173

Structure of mouse muskelin discoidin domain and biochemical characterization of its self-association  

Science Journals Connector (OSTI)

The structure of the discoidin domain from mouse muskelin has been determined and analysis of the interdomain interaction suggests a mechanism for self-association.

Kim, K.-H.

2014-10-16T23:59:59.000Z

174

E-Print Network 3.0 - adult mouse pancreas Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

mouse. Since there are human... expressed in the adult pancreas (data not ... Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo...

175

E-Print Network 3.0 - allergy mouse model Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

CBMC proliferation... -cockroach, anti-mouse, and anti-dust mite IgE levels, wheeze, cough, eczema and asthma. Results: ... Source: Columbia University, Department of...

176

Diarrhea as a cause of mortality in a mouse model of infectious colitis  

E-Print Network [OSTI]

Background: Comparative characterization of genome-wide transcriptional changes during infection can help elucidate the mechanisms underlying host susceptibility. In this study, transcriptional profiling of the mouse colon ...

Borenshtein, Diana

177

Development of a Three-Dimensional Ball Rotation Sensing System using Optical Mouse Sensors  

E-Print Network [OSTI]

to the case of a ball wheel. The system measures surface speed by using two or more optical mouse sensorsDevelopment of a Three-Dimensional Ball Rotation Sensing System using Optical Mouse Sensors Masaaki Kumagai and Ralph L. Hollis Abstract-- Robots using ball(s) as spherical wheels have the advantage

178

Prion Infection of Mouse Brain Reveals Multiple New Upregulated Genes Involved in Neuroinflammation or Signal Transduction  

Science Journals Connector (OSTI)

...research-article Prion Infection of Mouse Brain Reveals Multiple New Upregulated Genes Involved...response and signal transduction in mouse brain at various times after scrapie infection. In brains of scrapie-infected mice at pre- and post-clinical...

James A. Carroll; James F. Striebel; Brent Race; Katie Phillips; Bruce Chesebro

2014-12-10T23:59:59.000Z

179

Optical properties of the mouse eye Ying Geng,1,2,*  

E-Print Network [OSTI]

Optical properties of the mouse eye Ying Geng,1,2,* Lee Anne Schery,1 Robin Sharma,1,2 Alfredo, University of Rochester, Rochester, NY, 14627, USA 2 The Institute of Optics, University of Rochester indicate that the optical quality of the mouse eye assessed by measurement of its aberrations is remarkably

180

Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes  

E-Print Network [OSTI]

Review Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 379 7.3. Positive emotionality: food intake and responsivity to psychostimulants: Received 2 May 2009 Received in revised form 12 August 2009 Accepted 13 August 2009 Keywords: Mouse Rat

Kalueff, Allan V.

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Janus Experiments: Data from Mouse Irradiation Experiments 1972 - 1989  

DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

The Janus Experiments, carried out at Argonne National Laboratory from 1972 to 1989 and supported by grants from the US Department of Energy, investigated the effects of neutron and gamma radiation on mouse tissues primarily from B6CF1 mice. 49,000 mice were irradiated: Death records were recorded for 42,000 mice; gross pathologies were recorded for 39,000 mice; and paraffin embedded tissues were preserved for most mice. Mouse record details type and source of radiation [gamma, neutrons]; dose and dose rate [including life span irradiation]; type and presence/absence of radioprotector treatment; tissue/animal morphology and pathology. Protracted low dose rate treatments, short term higher dose rate treatments, variable dose rates with a same total dose, etc. in some cases in conjunction with radioprotectors, were administered. Normal tissues, tumors, metastases were preserved. Standard tissues saved were : lung, liver, spleen, kidney, heart, any with gross lesions (including mammary glands, Harderian gland with eye, adrenal gland, gut, ovaries or testes, brain and pituitary, bone). Data are searchable and specimens can be obtained by request.

182

Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice  

E-Print Network [OSTI]

al. ( 2007) Treatment of sickle cell anemia mouse model withan animal model of sickle cell anemia [36], or engraftment

2011-01-01T23:59:59.000Z

183

A Systematic Analysis of a Deep Mouse Epididymal Sperm Proteome  

SciTech Connect (OSTI)

Spermatozoa are highly specialized cells that, when mature, are capable of navigating the female reproductive tract and fertilizing an oocyte. The sperm cell is thought to be largely quiescent in terms of transcriptional and translational activity. As a result, once it has left the male reproductive tract, the sperm cell is essentially operating with a static population of proteins. It is therefore theoretically possible to understand the protein networks contained in a sperm cell and to deduce its cellular function capabilities. To this end we have performed a proteomic analysis of mouse sperm isolated from the cauda epididymis and have confidently identified 2,850 proteins, which is the most comprehensive sperm proteome for any species reported to date. These proteins comprise many complete cellular pathways, including those for energy production via glycolysis, ?-oxidation and oxidative phosphorylation, protein folding and transport, and cell signaling systems. This proteome should prove a useful tool for assembly and testing of protein networks important for sperm function.

Chauvin, Theodore; Xie, Fang; Liu, Tao; Nicora, Carrie D.; Yang, Feng; Camp, David G.; Smith, Richard D.; Roberts, Kenneth P.

2012-12-21T23:59:59.000Z

184

E-Print Network 3.0 - aged mouse ovaries Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ovaries Search Powered by Explorit Topic List Advanced Search Sample search results for: aged mouse ovaries Page: << < 1 2 3 4 5 > >> 1 Journal of Reproduction and Fertility (1994)...

185

E-Print Network 3.0 - adult mouse offspring Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Our strategy was to employ the A. fumigatus mouse model that induces... allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice Lin Lin1,...

186

The Design and Evaluation of Multi-Finger Mouse Emulation Techniques  

E-Print Network [OSTI]

, Jessica Lo, George Fitzmaurice Autodesk Research 210 King St. East, Toronto, Ontario, Canada, M5A 1J7 {firstname.lastname}@autodesk.com ABSTRACT We explore the use of multi-finger input to emulate full mouse

Toronto, University of

187

Metabolism of Benzo(a)pyrene by Variant Mouse Hepatoma Cells  

Science Journals Connector (OSTI)

...L. S.] and Biology Division, Oak Ridge National Laboratory [J. K. S.], P. 0. Box Y, Oak Ridge, Tennessee 37831 ABSTRACT Four mouse hepato'ma...density agrees with the results of these workers, but the observation of some production...

Eugene L. Schaefer and James K. Selkirk

1985-08-01T23:59:59.000Z

188

Abstract 3714: Trametinib (Mekinist TM) has limited brain distribution in the mouse model  

Science Journals Connector (OSTI)

...Trametinib (Mekinist TM) has limited brain distribution in the mouse model Shruthi...molecularly-targeted agents into the brain. The discovery of focal BRAF mutations...vemurafenib and dabrafenib) have limited brain distribution due to active efflux at the...

Shruthi Vaidhyanathan; Rajendar K. Mittapalli; Daniel J. Ma; Mark A. Schroeder; Jann N. Sarkaria; William F. Elmquist

2014-10-01T23:59:59.000Z

189

E-Print Network 3.0 - adult mouse brain Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

brain Search Powered by Explorit Topic List Advanced Search Sample search results for: adult mouse brain Page: << < 1 2 3 4 5 > >> 1 NMR IN BIOMEDICINE NMR Biomed. 2004;17:613619...

190

E-Print Network 3.0 - adult mouse heart Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

heart Search Powered by Explorit Topic List Advanced Search Sample search results for: adult mouse heart Page: << < 1 2 3 4 5 > >> 1 Seminars in Cell & Developmental Biology 18...

191

E-Print Network 3.0 - ameliorates mouse liver Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Diverse Roles of Invariant Natural Killer T Cells in Liver Injury and Fibrosis Induced by Carbon Tetrachloride Summary: are abundant in iNKT cells.13-17 For example, mouse liver...

192

in vivo Photothermal Optical Coherence Tomography of Targeted Mouse Brain Tumors using Gold Nanostars  

Science Journals Connector (OSTI)

We present structural and molecular-contrast imaging of mouse brain tumors using photo-thermal optical coherence tomography (PT-OCT) in vivo. Based on strong PT response of gold...

Heo, Jung; Jang, Eunji; Haam, Seungjoo; Oh, Seung Jae; Huh, Yong-Min; Suh, Jin-Suck; Chung, Euiheon; Joo, Chulmin

193

Microsoft Word - S05993_CY2009 Annual Rpt.doc  

Office of Legacy Management (LM)

97 97 3.2 Ecological Monitoring 3.2.1 Introduction The Ecology Group conducts ecological monitoring of the Site's ecological resources to ensure regulatory compliance and to preserve, protect, and manage those resources. Ecological monitoring is an integral aspect of determining whether the management objectives and goals for the natural resources at the Site are being achieved. This report summarizes the results of the ecological monitoring that was conducted at the Site during 2009. It does not include monitoring conducted for Preble's meadow jumping mouse mitigation and wetland mitigation activities. Those data are summarized in separate regulatory reports provided to the appropriate agencies. At an elevation of approximately 6,000 feet, the Site contains a unique ecotonal mixture of

194

Abstract A05: The Mouse Tumor Biology (MTB) Database: An electronic tool for identifying and evaluating mouse and PDX models of human cancer  

Science Journals Connector (OSTI)

...human tumors and provides freely available web access to these data. MTB integrates data...cancer research community and has developed a web-based system to facilitate submission...MPD), the Biology of the Mammary Gland Web Site, and the NCI Mouse Repository. MTB...

Dale A. Begley; Debra M. Krupke; Steven B. Neuhauser; Joel E. Richardson; John P. Sundberg; Carol J. Bult; Janan T. Eppig

2014-11-01T23:59:59.000Z

195

Mouse mammary tumor virus uses mouse but not human transferrin receptor 1 to reach a low pH compartment and infect cells  

SciTech Connect (OSTI)

Mouse mammary tumor virus (MMTV) is a pH-dependent virus that uses mouse transferrin receptor 1 (TfR1) for entry into cells. Previous studies demonstrated that MMTV could induce pH 5-dependent fusion-from-with of mouse cells. Here we show that the MMTV envelope-mediated cell-cell fusion requires both the entry receptor and low pH (pH 5). Although expression of the MMTV envelope and TfR1 was sufficient to mediate low pH-dependent syncytia formation, virus infection required trafficking to a low pH compartment; infection was independent of cathepsin-mediated proteolysis. Human TfR1 did not support virus infection, although envelope-mediated syncytia formation occurred with human cells after pH 5 treatment and this fusion depended on TfR1 expression. However, although the MMTV envelope bound human TfR1, virus was only internalized and trafficked to a low pH compartment in cells expressing mouse TfR1. Thus, while human TfR1 supported cell-cell fusion, because it was not internalized when bound to MMTV, it did not function as an entry receptor. Our data suggest that MMTV uses TfR1 for all steps of entry: cell attachment, induction of the conformational changes in Env required for membrane fusion and internalization to an appropriate acidic compartment.

Wang Enxiu; Obeng-Adjei, Nyamekye; Ying Qihua [Department of Microbiology and Abramson Family Cancer Center, University of Pennsylvania, 313BRBII/III, 421 Curie Blvd., Philadelphia, PA 19104 (United States); Meertens, Laurent; Dragic, Tanya [Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY (United States); Davey, Robert A. [Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX (United States); Ross, Susan R. [Department of Microbiology and Abramson Family Cancer Center, University of Pennsylvania, 313BRBII/III, 421 Curie Blvd., Philadelphia, PA 19104 (United States)], E-mail: rosss@mail.med.upenn.edu

2008-11-25T23:59:59.000Z

196

Activation of farnesoid X receptor induces RECK expression in mouse liver  

SciTech Connect (OSTI)

Highlights: RECK is a novel transcriptional target gene of FXR in mouse liver. The FXR response element is located within the intron 1 of RECK gene. FXR agonist reverses the down-regulation of RECK in the liver in mouse NASH model. -- Abstract: Farnesoid X receptor (FXR) belongs to the ligand-activated nuclear receptor superfamily, and functions as a transcription factor regulating the transcription of numerous genes involved in bile acid homeostasis, lipoprotein and glucose metabolism. In the present study, we identified RECK, a membrane-anchored inhibitor of matrix metalloproteinases, as a novel target gene of FXR in mouse liver. We found that FXR agonist substantially augmented hepatic RECK mRNA and protein expression in vivo and in vitro. FXR regulated the transcription of RECK through directly binding to FXR response element located within intron 1 of the mouse RECK gene. Moreover, FXR agonist reversed the down-regulation of RECK in the livers from mice fed a methionine and choline deficient diet. In summary, our data suggest that RECK is a novel transcriptional target of FXR in mouse liver, and provide clues to better understanding the function of FXR in liver.

Peng, Xiaomin [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China)] [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China); Wu, Weibin [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China) [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China); Institutes of Biomedical Sciences, Fudan University, Shanghai 200032 (China); Zhu, Bo; Sun, Zhichao; Ji, Lingling; Ruan, Yuanyuan [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China)] [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China); Zhou, Meiling, E-mail: meilingzhou2012@gmail.com [Department of Radiology, Zhongshan Hospital of Fudan University and Shanghai Institute of Medical Imaging, Shanghai 200032 (China)] [Department of Radiology, Zhongshan Hospital of Fudan University and Shanghai Institute of Medical Imaging, Shanghai 200032 (China); Zhou, Lei, E-mail: yhchloech@gmail.com [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China)] [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China); Gu, Jianxin [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China) [Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032 (China); Institutes of Biomedical Sciences, Fudan University, Shanghai 200032 (China)

2014-01-03T23:59:59.000Z

197

Mouse Strain-Dependent Variations in Sensitivity to Induction of Gamma-H2AX  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mouse Strain-Dependent Variations in Sensitivity to Induction of Gamma-H2AX Mouse Strain-Dependent Variations in Sensitivity to Induction of Gamma-H2AX Foci after Continuous Low Dose-Rate Irradiation: The Atm-/- vs Atm +/+ genotypes on Balb/c, 129S6, C57BL/6J, and A/J inbred strains J.R. Brogan Colorado State University Abstract We have recently developed a ‘low dose rate’ gamma-H2AX assay that is sufficiently sensitive to distinguish differences in response for cells from normal Atm +/+ (mouse) or ATM+/+ (human) and the phenotypes associated with the corresponding heterozygous genotypes(1, 2). The assay is also capable of distinguishing mild hypersensitivities for cells from an appreciable proportion of apparently normal individuals(3). We used this assay to determine whether the genetic background of four commonly used

198

Ultrastructural study of Rift Valley fever virus in the mouse model  

SciTech Connect (OSTI)

Detailed ultrastructural studies of Rift Valley fever virus (RVFV) in the mouse model are needed to develop and characterize a small animal model of RVF for the evaluation of potential vaccines and therapeutics. In this study, the ultrastructural features of RVFV infection in the mouse model were analyzed. The main changes in the liver included the presence of viral particles in hepatocytes and hepatic stem cells accompanied by hepatocyte apoptosis. However, viral particles were observed rarely in the liver; in contrast, particles were extremely abundant in the CNS. Despite extensive lymphocytolysis, direct evidence of viral replication was not observed in the lymphoid tissue. These results correlate with the acute-onset hepatitis and delayed-onset encephalitis that are dominant features of severe human RVF, but suggest that host immune-mediated mechanisms contribute significantly to pathology. The results of this study expand our knowledge of RVFV-host interactions and further characterize the mouse model of RVF.

Reed, Christopher; Steele, Keith E.; Honko, Anna; Shamblin, Joshua; Hensley, Lisa E. [United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, MD (United States)] [United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, MD (United States); Smith, Darci R., E-mail: darci.smith1@us.army.mil [United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, MD (United States)

2012-09-15T23:59:59.000Z

199

Laser-Assisted In Vitro Fertilization Facilitates Fertilization of Vitrified-Warmed C57BL/6 Mouse Oocytes with Fresh and Frozen-Thawed Spermatozoa, Producing Live Pups  

E-Print Network [OSTI]

The utility of cryopreserved mouse gametes for reproduction of transgenic mice depends on development of assisted reproductive technologies, including vitrification of unfertilized mouse oocytes. Due to hardening of the ...

Woods, Stephanie E.

200

Coxiella burnetii Isolates Cause Genogroup-Specific Virulence in Mouse and Guinea Pig Models of Acute Q Fever  

Science Journals Connector (OSTI)

...disease in the SCID mouse model, and genogroup-consistent...immunocompetent-mouse model. Guinea pigs developed...signs of (i) an acute flu-like illness with or...whether these groupings predict virulence potential and...but avirulent in rodent models of disease (47, 48...

K. E. Russell-Lodrigue; M. Andoh; M. W. J. Poels; H. R. Shive; B. R. Weeks; G. Q. Zhang; C. Tersteeg; T. Masegi; A. Hotta; T. Yamaguchi; H. Fukushi; K. Hirai; D. N. McMurray; J. E. Samuel

2009-09-28T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Screening for pain phenotypes: Analysis of three congenic mouse strains on a battery of nine nociceptive assays  

E-Print Network [OSTI]

Screening for pain phenotypes: Analysis of three congenic mouse strains on a battery of nine portion of the genome of the MOLF/Ei strain has been placed on a C57BL/6 genetic background ­ on a battery variability-causing genes), one for thermal nociception on mouse chromosome (Chr) 17 (Chr 17; Tpnr3) and one

Levitin, Daniel

202

Gene Expression Analysis Exposes Mitochondrial Abnormalities in a Mouse Model of Rett Syndrome  

Science Journals Connector (OSTI)

...and 0.4 M NaOH), the solution was overlaid with mineral oil and incubated for 5 h at 55C. Bisulfite-treated DNA was precipitated...Uqcrc1 coding sequence was PCR amplified from cDNA (Clontech MARATHON Ready mouse 11-day embryo cDNA) and cloned into pBABE Puro...

Skirmantas Kriaucionis; Andrew Paterson; John Curtis; Jacky Guy; Nikki MacLeod; Adrian Bird

2006-07-01T23:59:59.000Z

203

Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain  

E-Print Network [OSTI]

Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain Hans entire neuronal networks for analysis in the intact brain has been impossible up to now. Techniques like in micro computer tomogrpahy and mMRI does not resolve individual cells1,2. On a microscopic scale

Cai, Long

204

Triclosan as a Systemic Antibacterial Agent in a Mouse Model of Acute Bacterial Challenge  

Science Journals Connector (OSTI)

...Microbiology ARTICLE EXPERIMENTAL THERAPEUTICS Triclosan as a Systemic Antibacterial Agent in...and/or use of effective antibiotics. Triclosan, though used in cosmetic and dermatological...Here we report the striking efficacy of triclosan in a mouse model of acute systemic bacterial...

Shilpi Sharma; T. N. C. Ramya; Avadhesha Surolia; Namita Surolia

2003-12-01T23:59:59.000Z

205

Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer  

Science Journals Connector (OSTI)

...adenocarcinoma (PDAC). As dual MEK and PI3K inhibition is presently being employed in clinical trials for PDAC patients, we sought to test the efficacy of combined targeting of these pathways in PDAC using both in vitro drug screens and genetically engineered mouse...

Brinda Alagesan; Gianmarco Contino; Alexander R Guimaraes; Ryan B Corcoran; Vikram Desphande; Gregory R Wojtkiewicz; Aram F. Hezel; Kwok-Kin Wong; Massimo Loda; Ralph Weissleder; Cyril H Benes; Jeffrey A Engelman; Nabeel Bardeesy

206

Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution  

Science Journals Connector (OSTI)

...within tissues. For example, the 91,951 shared brain-selective DHSs in turn comprised four subclusters corresponding...versus human regulatory T cell DHSs and for mouse brain versus human fetal brain. In each case a linear relationship is observed...

Jeff Vierstra; Eric Rynes; Richard Sandstrom; Miaohua Zhang; Theresa Canfield; R. Scott Hansen; Sandra Stehling-Sun; Peter J. Sabo; Rachel Byron; Richard Humbert; Robert E. Thurman; Audra K. Johnson; Shinny Vong; Kristen Lee; Daniel Bates; Fidencio Neri; Morgan Diegel; Erika Giste; Eric Haugen; Douglas Dunn; Matthew S. Wilken; Steven Josefowicz; Robert Samstein; Kai-Hsin Chang; Evan E. Eichler; Marella De Bruijn; Thomas A. Reh; Arthur Skoultchi; Alexander Rudensky; Stuart H. Orkin; Thalia Papayannopoulou; Piper M. Treuting; Licia Selleri; Rajinder Kaul; Mark Groudine; M. A. Bender; John A. Stamatoyannopoulos

2014-11-21T23:59:59.000Z

207

Interaction of mouse mammary epithelial cells with collagen substrata: regulation of casein gene expression and secretion  

Science Journals Connector (OSTI)

...polyvinyl pyrrolidone and then hybridized with 32P-labeled, nick-translated mouse caseins or whey acidic protein (WAP) cDNA...matrix of mammary cells (29) to that of casein gene expression merit further investigation. We thank Dr. Jeffrey M. Rosen for...

E Y Lee; W H Lee; C S Kaetzel; G Parry; M J Bissell

1985-01-01T23:59:59.000Z

208

Effect of Sex Hormones on Susceptibility to Viral Transmission of Myeloid Leukemia in the Mouse  

Science Journals Connector (OSTI)

...passages. In every passage, the material from a given donor was injected...myeloid leukemia intheRF mouse. Materials and Methods HANDLING OF MICE. The animals used were...for 20mm. CHART 1. Schematic diagram of procedure for preparing the...

V. K. Jenkins; T. T. Odell, Jr.; and A. C. Upton

1966-03-01T23:59:59.000Z

209

Heart valve cardiomyocytes of mouse embryos express the serotonin transporter SERT  

SciTech Connect (OSTI)

Multiple evidence demonstrate a role for serotonin and its transporter SERT in heart valve development and disease. By utilizing a Cre/loxP system driven by SERT gene expression, we recently demonstrated a regionally restricted distribution of SERT-expressing cells in developing mouse heart. In order to characterize the cell types exhibiting SERT expression within the mouse heart valves at early developmental stages, in this study we performed immunohistochemistry for Islet1 (Isl1) and connexin-43 (Cx-43) on heart sections from SERT{sup Cre/+};ROSA26R embryos previously stained with X-gal. We observed the co-localization of LacZ staining with Isl1 labelling in the outflow tract, the right ventricle and the conal region of E11.5 mouse heart. Cx-43 labelled cells co-localized with LacZ stained cells in the forming atrioventricular valves. These results demonstrate the cardiomyocyte phenotype of SERT-expressing cells in heart valves of the developing mouse heart, thus suggesting an active role of SERT in early heart valve development.

Pavone, Luigi Michele [Department of Biological Structures, Functions and Technologies, University of Naples Federico II, Via F. Delpino 1, 80137 Naples (Italy); Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II, Naples (Italy)], E-mail: pavone@dbbm.unina.it; Spina, Anna; Lo Muto, Roberta; Santoro, Dionea [Department of Biological Structures, Functions and Technologies, University of Naples Federico II, Via F. Delpino 1, 80137 Naples (Italy); Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II, Naples (Italy); Mastellone, Vincenzo [Department of Experimental Medicine 'G. Salvatore', University of Magna Graecia, Catanzaro (Italy); Avallone, Luigi [Department of Biological Structures, Functions and Technologies, University of Naples Federico II, Via F. Delpino 1, 80137 Naples (Italy)

2008-12-12T23:59:59.000Z

210

SkyMouse: A smart interface for astronomical on-line resources and services  

E-Print Network [OSTI]

With the development of network and the World Wide Web (WWW), the Internet has been growing and changing dramatically. More and more on-line database systems and different kinds of services are available for astronomy research. How to help users find their way through the jungle of information services becomes an important challenge. Although astronomers have been aware of the importance of interoperability and introduced the concept of Virtual Observatory as a uniform environment for future astronomical on-line resources and services, transparent access to heterogeneous on-line information is still difficult. SkyMouse is a lightweight interface for distributed astronomical on-line resources and services, which is designed and developed by us, i.e., Chinese Virtual Observatory Project. Taking advantage of screen word-capturing technology, different kinds of information systems can be queried through simple mouse actions, and results are returned in a uniform web page. SkyMouse is an easy to use application, aiming to show basic information or to create a comprehensive overview of a specific astronomical object. In this paper current status of on-line resources and services access is reviewed; system architecture, features and functions of SkyMouse are described; challenges for intelligent interface for on-line astronomical resources and services are discussed.

Chen-Zhou CUI; Hua-Ping SUN; Yong-Heng ZHAO; Yu LUO; Da-Zhi QI

2007-11-27T23:59:59.000Z

211

Lack of T-Cell Immunity in Humans with Preexisting Anti-Mouse Immunoglobulin Reactivity  

Science Journals Connector (OSTI)

...nocarcinomas called TAG-72 (17), was a generous gift from Dr. Jeffery Schlom, NIH. Normal polyclonal mouse IgG and normal polyclonal...coiorectal cancer. J. Nucl. Med., 33: 23-29, 1992. 3. Benjamin, D. C., Berzofsky, J. A., East, I. J., Grud, F...

Robert M. Conry; M. B. Khazaeli; and Albert F. LoBuglio

1992-12-15T23:59:59.000Z

212

Metabolism and pharmacokinetics of the cyclin-dependent kinase inhibitor R-roscovitine in the mouse  

Science Journals Connector (OSTI)

...hepatic microsomes, plasma, and urine. Following...under an argon atmosphere cooled to 0C was...d6-DMSO, 250 MHz): delta 4.62...d6-DMSO, 250 MHz): delta 0.82...25-hour mouse plasma samples from treated...aliquots (33 muL) of plasma from three animals...

Bernard P. Nutley; Florence I. Raynaud; Stuart C. Wilson; Peter M. Fischer; Angela Hayes; Phyllis M. Goddard; Steven J. McClue; Michael Jarman; David P. Lane; and Paul Workman

2005-01-01T23:59:59.000Z

213

Behavior of Three Types of Ribovirus-Like Particles in Segregating Hamster Mouse Somatic Hybrids  

Science Journals Connector (OSTI)

...fortuitous, fluctuations of R particle con- tent may well be correlated...Sci. USA 71 (1974) Virus Particles in Hamster X Mouse Somatic...e Of. z 'to Eli . , r en god ^ t ; I;; i ' ' ;t': U...100 nm. Fig. 2: R-type particles in a hamster melanoma cell...

Y. Yotsuyanagi; Boris Ephrussi

1974-01-01T23:59:59.000Z

214

Automated whole-genome multiple alignment of rat, mouse, and human  

SciTech Connect (OSTI)

We have built a whole genome multiple alignment of the three currently available mammalian genomes using a fully automated pipeline which combines the local/global approach of the Berkeley Genome Pipeline and the LAGAN program. The strategy is based on progressive alignment, and consists of two main steps: (1) alignment of the mouse and rat genomes; and (2) alignment of human to either the mouse-rat alignments from step 1, or the remaining unaligned mouse and rat sequences. The resulting alignments demonstrate high sensitivity, with 87% of all human gene-coding areas aligned in both mouse and rat. The specificity is also high: <7% of the rat contigs are aligned to multiple places in human and 97% of all alignments with human sequence > 100kb agree with a three-way synteny map built independently using predicted exons in the three genomes. At the nucleotide level <1% of the rat nucleotides are mapped to multiple places in the human sequence in the alignment; and 96.5% of human nucleotides within all alignments agree with the synteny map. The alignments are publicly available online, with visualization through the novel Multi-VISTA browser that we also present.

Brudno, Michael; Poliakov, Alexander; Salamov, Asaf; Cooper, Gregory M.; Sidow, Arend; Rubin, Edward M.; Solovyev, Victor; Batzoglou, Serafim; Dubchak, Inna

2004-07-04T23:59:59.000Z

215

Comparative Analysis of the -Like Globin Clusters in Mouse, Rat, and Human Chromosomes Indicates a  

E-Print Network [OSTI]

to GenBank/EMBL under accession no. AY016022.] Genome sequencing projects and comparative genome analysesComparative Analysis of the -Like Globin Clusters in Mouse, Rat, and Human Chromosomes Indicates -globin pseudogene. Comparative sequence analysis with the functional -globin loci at human Chromosome 16p

Miller, Webb

216

In vivo fluorescent imaging of the mouse retina using adaptive optics  

E-Print Network [OSTI]

in the retina of a mouse, using a microelectromechanical system membrane mirror and a Shack­Hartmann wave- front is a powerful tool that allows fol- lowing a single animal over time. A major problem with implementing (Dual Calypso laser, Co- bolt AB, Stockholm, Sweden). An entrance pupil is formed at the source

217

12/4/09 10:18 AMComputer Power User Article -X-ray Vision: Built-In Repair Centers Page 1 of 1http://www.computerpoweruser.com/editorial/article.asp?article=art...B2C52BEC685E6F18&searchtype=0&WordList=JEFFREY+MOORE&bJumpTo=True  

E-Print Network [OSTI]

://www.computerpoweruser.com/editorial/article.asp?article=art...B2C52BEC685E6F18&searchtype=0&WordList=JEFFREY+MOORE&bJumpTo=True Home | Forums | Article Search

Braun, Paul

218

DOI-BLM-NV-C010-2011-0516-EA | Open Energy Information  

Open Energy Info (EERE)

516-EA 516-EA Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home NEPA Document Collection for: DOI-BLM-NV-C010-2011-0516-EA EA at Dixie Meadows Geothermal Area for Geothermal/Exploration, Geothermal/Well Field Dixie Meadows Geothermal Exploration Project General NEPA Document Info Energy Sector Geothermal energy Environmental Analysis Type EA Applicant Ormat Technologies Inc Consultant JBR Environmental Consultants, Inc. Geothermal Area Dixie Meadows Geothermal Area Project Location Nevada Project Phase Geothermal/Exploration, Geothermal/Well Field Techniques Drilling Techniques, Thermal Gradient Holes Time Frame (days) Application Time 308 NEPA Process Time 510 Participating Agencies Lead Agency BLM Funding Agency none provided Managing District Office Carson City

219

In Vivo Three-photon Calcium Imaging of Brain Activity from Layer 6 Neurons in Mouse Brain  

Science Journals Connector (OSTI)

We demonstrate three-photon microscopy (3PM) at 1300-nm excitation for imaging neuronal activity as deep as layer-6 (L6) of adult mouse cortex using genetically-encoded calcium...

Ouzounov, Dimitre G; Horton, Nicholas; Wang, Tianyu; Feng, Danielle; Nishimura, Nozomi; Xu, Chris

220

The mapping of natural boron in histological sections of mouse tissues by the use of neutron-capture radiography  

Science Journals Connector (OSTI)

Neutron-capture radiography has been applied to the mapping of natural boron in mouse histological sections. The method is based on the fact that the stable isotope boron-10 has an extremely large cross-section f...

Maria Laurent-Pettersson; Bertrand Delpech; Michel Thellier

1992-12-01T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Rapid Structural Remodeling of Thalamocortical Synapses Parallels Experience-Dependent Functional Plasticity in Mouse Primary Visual Cortex  

E-Print Network [OSTI]

Monocular lid closure (MC) causes a profound shift in the ocular dominance (OD) of neurons in primary visual cortex (V1). Anatomical studies in both cat and mouse V1 suggest that large-scale structural rearrangements of ...

Coleman, Jason E.

222

The Consensus Coding Sequence (Ccds) Project: Identifying a Common Protein-Coding Gene Set for the Human and Mouse Genomes  

E-Print Network [OSTI]

Effective use of the human and mouse genomes requires reliable identification of genes and their products. Although multiple public resources provide annotation, different methods are used that can result in similar but ...

Kellis, Manolis

223

Low LET Radiation Alters the Fetal Epigenome of the Avy Mouse  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

LET Radiation Alters the Fetal Epigenome of the Avy Mouse LET Radiation Alters the Fetal Epigenome of the Avy Mouse Randy Jirtle Duke University Medical Center Abstract Exposure to high levels of ionizing radiation significantly alters the epigenome in somatic cells and gametes (Filkowski and others, 2009), yet it has not been determined if epigenomic modifications occur below 10 cGy. Epigenetic dysregulation during early development is mechanistically linked to the pathogenesis of adult-onset diseases (Jirtle and Skinner, 2007). Thus, we sought to determine whether low doses of ionizing radiation during early gestation affect susceptibility to adult-onset diseases by deregulating the establishment of DNA methylation patterns. Agouti viable yellow (Avy) mice were used to test this novel postulate because they are

224

The low dose damage response pathways in the mouse mammary glands depends  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

low dose damage response pathways in the mouse mammary glands depends low dose damage response pathways in the mouse mammary glands depends on genotype, tissue compartment, exposure regimen, and sampling times Joe Gray & Andrew Wyrobek Lawrence Berkeley National Laboratory Abstract The objectives of this research are to characterize the early and persistent low-dose and adaptive response (AR) damage surveillance networks in mammary glands of radiation sensitive and resistant strains of mice to identify the molecular signatures/mechanisms associated with nonlinear modifications of risk for mammary gland cancer. Our approach uses low-dose exposure regimens that have been reported to induce mammary gland cancer in sensitive strains to determine whether low-dose induced pathways are differentially expressed in epithelial or stromal cells and to determine

225

Genetic susceptibility to low-dose ionizing radiation in the mouse mammary  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Genetic susceptibility to low-dose ionizing radiation in the mouse mammary Genetic susceptibility to low-dose ionizing radiation in the mouse mammary gland as a means of understanding human risk for breast cancer Antoine M. Snijders Lawrence Berkeley National Laboratory Abstract Goal: Our goal is to develop an in vivo mechanistic model of genetic variation in the low-dose damage responses of mammary glands using inbred mice known to vary in their sensitivity to low-dose induced mammary gland cancer, and to develop molecular predictors for susceptibility or resistance to low-dose induced breast cancer. Background and Significance: It is increasingly believed that individuals differ in their genetic susceptibilities to environmental insults for diseases such as cancer. This concern is especially important for the large numbers of individuals receiving low-dose exposures in the nuclear energy

226

Gene Expression Analysis of Apoptosis and Oxidative Stress in Mouse Brain  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Analysis of Apoptosis and Oxidative Stress in Mouse Brain Analysis of Apoptosis and Oxidative Stress in Mouse Brain After Low-dose and Acute Radiation Exposure Daila Gridley Loma Linda University & Medical Center Abstract Purpose: 1) To examine the induction of oxidative stress and apoptosis-associated gene expression profiles in brain after whole-body irradiation with low-dose/low-dose-rate (LDR) photons and acute exposure to photons 2) to compare these radiation-induced effects with those produced by LDR and acute exposure to protons. Material and Methods: C57BL/6 mice were exposed to 2 Gy of photons or protons at 0.8 Gy/min and 0.9 Gy/min, respectively, both with and without pre-exposure to 0.01 Gy LDR γ-rays (57Co) at 0.03 cGy/h. Brain tissues were harvested and quick-frozen for analyses by quantitative RTPCR at 56

227

Human-mouse comparative genomics: successes and failures to reveal functional regions of the human genome  

SciTech Connect (OSTI)

Deciphering the genetic code embedded within the human genome remains a significant challenge despite the human genome consortium's recent success at defining its linear sequence (Lander et al. 2001; Venter et al. 2001). While useful strategies exist to identify a large percentage of protein encoding regions, efforts to accurately define functional sequences in the remaining {approx}97 percent of the genome lag. Our primary interest has been to utilize the evolutionary relationship and the universal nature of genomic sequence information in vertebrates to reveal functional elements in the human genome. This has been achieved through the combined use of vertebrate comparative genomics to pinpoint highly conserved sequences as candidates for biological activity and transgenic mouse studies to address the functionality of defined human DNA fragments. Accordingly, we describe strategies and insights into functional sequences in the human genome through the use of comparative genomics coupled wit h functional studies in the mouse.

Pennacchio, Len A.; Baroukh, Nadine; Rubin, Edward M.

2003-05-15T23:59:59.000Z

228

Comparative metabolism of phenobarbitone in the rat (CFE) and mouse (CF1)  

Science Journals Connector (OSTI)

The fate of orally administered [14C]phenobarbitone (40 mg/kg) was studied comparatively in CFE rats and CF1 mice. Metabolism and elimination were rapid. Hydroxylation was more complete in rats than in mice but the major metabolite in both species was p-hydroxyphenobarbitone, which was excreted mostly in the urine in both free and conjugated form. Unmetabolized phenobarbitone was excreted in the urine of both rat and mouse. Two minor metabolites appeared to be common to both species. The effect of pretreatment with non-radioactive phenobarbitone on the metabolism of [14C]phenobarbitone was minimal in the rat but afforded a twofold increase in p-hydroxylation in the mouse (in vivo). Despite the good yield of p-hydroxyphenobarbitone in the intact rat, [14C]phenobarbitone was not metabolized by liver-microsomal preparations from either untreated or phenobarbitone-induced rats.

J.V. Crayford; D.H. Hutson

1980-01-01T23:59:59.000Z

229

FUNCTIONAL AND MECHANISTIC STUDY OF DOT1L IN MOUSE EMBRYONIC HEMATOPOIESIS  

E-Print Network [OSTI]

recognized that two distinct populations of red cells circulate in the blood stream of mouse embryos. The first population, the primitive red cells, are extremely large, nucleated red cells, which originate from the yolk sac2. Shortly after that, a second... to our increasing knowledge over time. For example, at first the primitive red cells are thought to be always nucleated and have the same characteristics with the nucleated nonmammalian red cells. Also originally, people believed that definitive...

Feng, Yi

2012-12-31T23:59:59.000Z

230

Genomic Imprinting Variations in the Mouse Type 3 Deiodinase Gene Between Tissues and Brain Regions  

E-Print Network [OSTI]

, tissues were dissected, immediately frozen on dry ice and stored at 70 C until further use. Brain regions were identified and harvested according to the mouse atlas by Paxinos (30). Animal procedures were approved by the Institutional Animal Care and Use... paternal, allele. This suggests that expression and associated alterations in chromatin facil- itate homologous recombination. The result is also con- sistent with observations that suggest the existence of epi- genetic boundaries that are associated with a...

Martinez, M. Elena; Charalambous, Marika; Saferali, Aabida; Fiering, Steven; Naumova, Anna K.; St. Germain, Donald; Ferguson-Smith, Anne C.; Hernandez, Arturo

2014-09-18T23:59:59.000Z

231

Polymictic pool behavior in a montane meadow, Sierra Nevada, CA  

E-Print Network [OSTI]

scale measurements, such as DTS or FLIR, and may help assessForward Looking Infrared ( FLIR) is often used in studiesLoheide and Gorelick, 2006). FLIR only captures the surface

Lucas, Ryan Geoffrey

2013-01-01T23:59:59.000Z

232

Environmental Impact Statement Truckee Meadows Flood Control Project  

E-Print Network [OSTI]

-construction Engineering and Design (PED) phase when changes in real estate costs made the project economically infeasible, and environmentally sustainable design features over an anticipated multi-year construction period. This Draft EIS

US Army Corps of Engineers

233

Saving Money and Fuel with a Click of a Mouse | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Money and Fuel with a Click of a Mouse Money and Fuel with a Click of a Mouse Saving Money and Fuel with a Click of a Mouse January 10, 2012 - 4:19pm Addthis A look at tools that can help consumers save money and fuel, whether you’re in the market for a new vehicle or trying to make the most of your current one. | Photo courtesy of Auto Guide. A look at tools that can help consumers save money and fuel, whether you're in the market for a new vehicle or trying to make the most of your current one. | Photo courtesy of Auto Guide. Patrick B. Davis Patrick B. Davis Vehicle Technologies Program Manager What does this mean for me? Quickly compare cars based on their projected fuel costs, price, safety ratings and MPG. Calculate the long-term costs of your next vehicle. Discover simple tips and tricks that can start saving you fuel and

234

Dynamic changes in the distribution and time course of bloodbrain barrier-permeative nitroxides in the mouse head with EPR imaging: visualization of blood flow in a mouse model of ischemia  

Science Journals Connector (OSTI)

Abstract Electron paramagnetic resonance (EPR) imaging using nitroxides as redox-sensitive probes is a powerful, noninvasive method that can be used under various physiological conditions to visualize changes in redox status that result from oxidative damage. Two bloodbrain barrier-permeative nitroxides, 3-hydroxymethyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (HMP) and 3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-1-yloxy (MCP), have been widely used as redox-sensitive probes in the brains of small animals, but their in vivo distribution and properties have not yet been analyzed in detail. In this study, a custom-made continuous-wave three-dimensional (3D) EPR imager was used to obtain 3D EPR images of mouse heads using MCP or HMP. This EPR imager made it possible to take 3D EPR images reconstructed from data from 181 projections acquired every 60s. Using this improved EPR imager and magnetic resonance imaging, the distribution and reduction time courses of HMP and MCP were examined in mouse heads. EPR images of living mice revealed that HMP and MCP have different distributions and different time courses for entering the brain. Based on the pharmacokinetics of the reduction reactions of HMP and MCP in the mouse head, the half-lives of HMP and MCP were clearly and accurately mapped pixel by pixel. An ischemic mouse model was prepared, and the half-life of MCP was mapped in the mouse head. Compared to the half-life in control mice, the half-life of MCP in the ischemic model mouse brain was significantly increased, suggesting a shift in the redox balance. This in vivo EPR imaging method using BBB-permeative MCP is a useful noninvasive method for assessing changes in the redox status in mouse brains under oxidative stress.

Miho C. Emoto; Hideo Sato-Akaba; Hiroshi Hirata; Hirotada G. Fujii

2014-01-01T23:59:59.000Z

235

Differential effects of triclosan on the activation of mouse and human peroxisome proliferator-activated receptor alpha  

Science Journals Connector (OSTI)

Abstract Triclosan is an anti-bacterial agent used in many personal care products, household items, medical devices, and clinical settings. Liver tumors occur in mice exposed to triclosan, a response attributed to peroxisome proliferator-activated receptor alpha (PPAR?) activation; however, the effects of triclosan on mouse and human PPAR? have not been fully evaluated. We compared the effects of triclosan on mouse and human PPAR? using PPAR? reporter assays and on downstream events of PPAR? activation using mouse hepatoma Hepa1c1c7 cells and human hepatoma HepG2 cells. PPAR? transcriptional activity was increased by triclosan in a mouse PPAR? reporter assay and decreased in a human PPAR? reporter assay. Concentrations of triclosan inhibiting 50% cell growth were similar in both human and mouse hepatoma cells. Western blotting analysis showed that triclosan increased acyl-coenzyme A oxidase (ACOX1), a PPAR? target, in Hepa1c1c7 cells but decreased the level in HepG2 cells. Treatment of Hepa1c1c7 cells with triclosan enhanced DNA synthesis and suppressed transforming growth factor beta-mediated apoptosis. This did not occur in HepG2 cells. These data demonstrate that triclosan had similar cytotoxicity in Hepa1c1c7 and HepG2 cells, but differential effects on the activation of PPAR?, the expression of ACOX1, and downstream events including DNA synthesis and apoptosis.

Yuanfeng Wu; Qiangen Wu; Frederick A. Beland; Peter Ge; Mugimane G. Manjanatha; Jia-Long Fang

2014-01-01T23:59:59.000Z

236

Application of the optically stimulated luminescence (OSL) technique for mouse dosimetry in micro-CT imaging  

SciTech Connect (OSTI)

Purpose: Micro-CT is considered to be a powerful tool to investigate various models of disease on anesthetized animals. In longitudinal studies, the radiation dose delivered by the micro-CT to the same animal is a major concern as it could potentially induce spurious effects in experimental results. Optically stimulated luminescence dosimeters (OSLDs) are a relatively new kind of detector used in radiation dosimetry for medical applications. The aim of this work was to assess the dose delivered by the CT component of a micro-SPECT (single-photon emission computed tomography)/CT camera during a typical whole-body mouse study, using commercially available OSLDs based on Al{sub 2}O{sub 3}:C crystals.Methods: CTDI (computed tomography dose index) was measured in micro-CT with a properly calibrated pencil ionization chamber using a rat-like phantom (60 mm in diameter) and a mouse-like phantom (30 mm in diameter). OSLDs were checked for reproducibility and linearity in the range of doses delivered by the micro-CT. Dose measurements obtained with OSLDs were compared to those of the ionization chamber to correct for the radiation quality dependence of OSLDs in the low-kV range. Doses to tissue were then investigated in phantoms and cadavers. A 30 mm diameter phantom, specifically designed to insert OSLDs, was used to assess radiation dose over a typical whole-body mouse imaging study. Eighteen healthy female BALB/c mice weighing 27.1 0.8 g (1 SD) were euthanized for small animal measurements. OLSDs were placed externally or implanted internally in nine different locations by an experienced animal technician. Five commonly used micro-CT protocols were investigated.Results: CTDI measurements were between 78.0 2.1 and 110.7 3.0 mGy for the rat-like phantom and between 169.3 4.6 and 203.6 5.5 mGy for the mouse-like phantom. On average, the displayed CTDI at the operator console was underestimated by 1.19 for the rat-like phantom and 2.36 for the mouse-like phantom. OSLDs exhibited a reproducibility of 2.4% and good linearity was found between 60 and 450 mGy. The energy scaling factor was calculated to be between 1.80 0.16 and 1.86 0.16, depending on protocol used. In phantoms, mean doses to tissue over a whole-body CT examination were ranging from 186.4 7.6 to 234.9 7.1 mGy. In mice, mean doses to tissue in the mouse trunk (thorax, abdomen, pelvis, and flanks) were between 213.0 17.0 and 251.2 13.4 mGy. Skin doses (3 OSLDs) were much higher with average doses between 350.6 25.3 and 432.5 34.1 mGy. The dose delivered during a topogram was found to be below 10 mGy. Use of the multimouse bed of the system gave a significantly 20%40% lower dose per animal (p < 0.05).Conclusions: Absorbed doses in micro-CT were found to be relatively high. In micro-SPECT/CT imaging, the micro-CT unit is mainly used to produce a localization frame. As a result, users should pay attention to adjustable CT parameters so as to minimize the radiation dose and avoid any adverse radiation effects which may interfere with biological parameters studied.

Vrigneaud, Jean-Marc; Courteau, Alan; Oudot, Alexandra; Collin, Bertrand [Department of Nuclear Medicine, Centre Georges-Franois Leclerc, 1 rue Professeur Marion, Dijon 21079 Cedex (France)] [Department of Nuclear Medicine, Centre Georges-Franois Leclerc, 1 rue Professeur Marion, Dijon 21079 Cedex (France); Ranouil, Julien [Landauer Europe, 33 avenue du Gnral Leclerc, Fontenay-aux-Roses 92266 Cedex (France)] [Landauer Europe, 33 avenue du Gnral Leclerc, Fontenay-aux-Roses 92266 Cedex (France); Morgand, Loc; Raguin, Olivier [Oncodesign, 20 rue Jean Mazen, Dijon 21076 Cedex (France)] [Oncodesign, 20 rue Jean Mazen, Dijon 21076 Cedex (France); Walker, Paul [LE2i CNRS UMR 5158, Faculty of Medicine, BP 87900, 21079 Dijon Cedex (France)] [LE2i CNRS UMR 5158, Faculty of Medicine, BP 87900, 21079 Dijon Cedex (France); Brunotte, Franois [Department of Nuclear Medicine, Centre Georges-Franois Leclerc, 1 rue Professeur Marion, Dijon 21079 Cedex, France and LE2i CNRS UMR 5158, Faculty of Medicine, BP 87900, 21079 Dijon Cedex (France)] [Department of Nuclear Medicine, Centre Georges-Franois Leclerc, 1 rue Professeur Marion, Dijon 21079 Cedex, France and LE2i CNRS UMR 5158, Faculty of Medicine, BP 87900, 21079 Dijon Cedex (France)

2013-12-15T23:59:59.000Z

237

Proteome and Transcriptome Profiles of a Her2/Neu-driven Mouse Model of Breast Cancer  

SciTech Connect (OSTI)

In recent years, mouse models have proven to be invaluable in expanding our understanding of cancer biology. We have amassed a tremendous amount of proteomics and transcriptomics data profiling blood and tissues from a Her2-driven mouse model of breast cancer that closely recapitulates the pathology and natural history of human breast cancer. The purpose of this report is to make all of these data publicly available in raw and processed forms, as a resource to the community. Importantly, high quality biospecimens from this same mouse model are freely available through a sample repository that we established, so researchers can readily obtain samples to test biological hypotheses without the need of breeding animals and collecting biospecimens. Specifically, six proteomics and six transcriptomics datasets are available, with the former encompassing 841 liquid chromatography-tandem mass spectrometry (LC-MS/MS) experiments of both plasma and tissue samples, and the latter including 255 individual microarray analyses of five different tissue types (thymus, spleen, liver, blood cells, and breast laser capture microdissection). A total of 18,880 unique peptides were identified with a PeptideProphet error rate ?1%, with 3884 non-redundant protein groups identified in five plasma datasets, and 1659 non-redundant protein groups in a tissue dataset (4977 non-redundant protein groups in total). We anticipate that these data will be of use to the community for software tool development, investigations of analytical variation in MS/MS data, development of quality control tools (multiple technical replicates are provided for a subset of the data), empirical selection of proteotypic peptides for multiple reaction monitoring mass spectrometry, and for advancing our understanding of cancer biology.

Schoenherr, Regine M.; Kelly-Spratt, Karen S.; Lin, Chen Wei; Whiteaker, Jeffrey R.; Liu, Tao; Holzman, Ted; Coleman, Ilsa; Feng, Li-Chia; Lorentzen, Travis D.; Krasnoselsky, Alexei L.; Wang, Pei; Liu, Yan; Gurley, Kay E.; Amon, Lynn M.; Schepmoes, Athena A.; Moore, Ronald J.; Camp, David G.; Chodosh, Lewis A.; Smith, Richard D.; Nelson, Peter S.; McIntosh, Martin; Kemp, Christopher; Paulovich, Amanda G.

2011-04-01T23:59:59.000Z

238

Sertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic hearts  

SciTech Connect (OSTI)

Highlights: SERTAD1 interacts with SMAD1. Sertad1 is expressed in mouse embryonic hearts. SERTAD1 is localized in both cytoplasm and nucleus of cardiomyocytes. SERTAD1 enhances expression of BMP target cardiogenic genes as a SMAD1 co-activator. -- Abstract: Despite considerable advances in surgical repairing procedures, congenital heart diseases (CHDs) remain the leading noninfectious cause of infant morbidity and mortality. Understanding the molecular/genetic mechanisms underlying normal cardiogenesis will provide essential information for the development of novel diagnostic and therapeutic strategies against CHDs. BMP signaling plays complex roles in multiple cardiogenic processes in mammals. SMAD1 is a canonical nuclear mediator of BMP signaling, the activity of which is critically regulated through its interaction partners. We screened a mouse embryonic heart yeast two-hybrid library using Smad1 as bait and identified SERTAD1 as a novel interaction partner of SMAD1. SERTAD1 contains multiple potential functional domains, including two partially overlapping transactivation domains at the C terminus. The SERTAD1-SMAD1 interaction in vitro and in mammalian cells was further confirmed through biochemical assays. The expression of Sertad1 in developing hearts was demonstrated using RT-PCR, western blotting and in situ hybridization analyses. We also showed that SERTAD1 was localized in both the cytoplasm and nucleus of immortalized cardiomyocytes and primary embryonic cardiomyocyte cultures. The overexpression of SERTAD1 in cardiomyocytes not only enhanced the activity of two BMP reporters in a dose-dependent manner but also increased the expression of several known BMP/SMAD regulatory targets. Therefore, these data suggest that SERTAD1 acts as a SMAD1 transcriptional co-activator to promote the expression of BMP target genes during mouse cardiogenesis.

Peng, Yin [Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294 (United States)] [Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294 (United States); Zhao, Shaomin [Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294 (United States) [Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294 (United States); School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069 (China); Song, Langying [Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294 (United States)] [Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294 (United States); Wang, Manyuan [School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069 (China)] [School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069 (China); Jiao, Kai, E-mail: kjiao@uab.edu [Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294 (United States)] [Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294 (United States)

2013-11-29T23:59:59.000Z

239

Comparative promoter activities of three endogenous copies of mouse mammary tumor virus  

E-Print Network [OSTI]

to 12 CC ~ o c 0 tu x MMTV M13 pLC1 ?(, a~ CAT pBR322 0/ I SV40 Figure 5. Diagram of pLC1. The plasmid pLC1 (Toohey et al. , 1986) contains an Intact LTR obtained from the C3H provirus as a Pst I restriction fragment. The plasmid also...COMPARATIVE PROMOTER ACTIVITIES OF THREE ENDOGENOUS COPIES OF MOUSE MAMMARY TUMOR VIRUS A Thesis by LAURA REID VILANDER Submitted to the Graduate College of Texas A&M University in partial fulfilment of the requirements for the degree...

Vilander, Laura Reid

1987-01-01T23:59:59.000Z

240

The genetic control of avascular area in mouse oxygen-induced retinopathy  

E-Print Network [OSTI]

The genetic control of avascular area in mouse oxygen-induced retinopathy Bliss E. OBryhim,1,2 Jeff Radel,1,2,3 Stuart J. Macdonald,4 R.C. Andrew Symons1,2 1Department of Ophthalmology, University of Kansas Medical Center, Kansas City, KS; 2... exposure to hyperoxia, as well as quantitative trait loci on chromosomes 7 and 9 that modify susceptibility to OIR. Retinopathy of prematurity (ROP) is a leading cause of vision loss in children in both developed and developing countries [13]. ROP is a...

O'Bryhim, Bliss; Radel, Jeff; Macdonald, Stuart J.; Symons, R. C. Andrew

2012-02-08T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Pointright: a system to redirect mouse and keyboard control among multiple machines  

DOE Patents [OSTI]

The present invention provides a software system, PointRight, that allows for smooth and effortless control of pointing and input devices among multiple displays. With PointRight, a single free-floating mouse and keyboard can be used to control multiple screens. When the cursor reaches the edge of a screen it seamlessly moves to the adjacent screen and keyboard control is simultaneously redirected to the appropriate machine. Laptops may also redirect their keyboard and pointing device, and multiple pointers are supported simultaneously. The system automatically reconfigures itself as displays go on, go off, or change the machine they display.

Johanson, Bradley E. (Palo Alto, CA); Winograd, Terry A. (Stanford, CA); Hutchins, Gregory M. (Mountain View, CA)

2008-09-30T23:59:59.000Z

242

Embryotoxic and histopathologic effects of aflatoxin B1 during early pregnancy in the mouse  

E-Print Network [OSTI]

During Early Pregnancy in the Mouse, (August 1990) Ying Jia-Hsu, M. D. , Capital Institute of Medicine Co-chairs of Advisory Committee: Dr. T, Rick Irvin Dr. John E. Martin The in vivo embryotoxicity of aflatoxin Bl (AFB1) on mice..., and with histopathologic changes that occur as a result of exposure to AFB1 at a single maximum tolerate dose on gestation day 2 or gestation day 4 were characterized, and the correlation of the embryotoxic and histopathologic effects of AFB1 on pregnant mice...

Jia-Hsu, Ying

2012-06-07T23:59:59.000Z

243

Vertical Jump: Biomechanical Analysis and Simulation Study  

E-Print Network [OSTI]

movements that do not imitate the human motion. Besides, these slow and statically stable movements of common properties. To achieve a better imitation of the human motion and ability to perform fast of rotational energy are involved, high power is necessary to decelerate the angular motion. Source: Humanoid

Babic, Jan

244

Seismic tomography with the reversible jump algorithm  

Science Journals Connector (OSTI)

......form. In practice, we are at liberty to generate the nuclei using...2-D region. That is, we project the partition models into the...because at each iteration, it projects the full linearized inverse...Government Programme. This project was also supported by a French-Australian......

Thomas Bodin; Malcolm Sambridge

2009-09-01T23:59:59.000Z

245

Off to a flying jump-start  

Science Journals Connector (OSTI)

... take flight. Could this also be how their distant ancestors got off the ground? John Whitfield investigates. start in life, explains David Adam. Once a body is off ...

John Whitfield

2000-03-10T23:59:59.000Z

246

Simulating Temperature Jumps for Protein Folding Studies.  

E-Print Network [OSTI]

??Protein folding is described as a dynamic process of an ensemble of molecules reaching well-defined three dimensional structures to achieve biological activity from linear amino (more)

Kim, Seonah

2007-01-01T23:59:59.000Z

247

Dynamics of Snapping Beams and Jumping Poppers  

E-Print Network [OSTI]

We consider the dynamic snapping instability of elastic beams and shells. Using the Kirchhoff rod and F\\"{o}ppl-von K\\'{a}rm\\'{a}n plate equations, we study the stability, deformation modes, and snap-through dynamics of an elastic arch with clamped boundaries and subject to a concentrated load. For parameters typical of everyday and technological applications of snapping, we show that the stretchability of the arch plays a critical role in determining not only the post-buckling mode of deformation but also the timescale of snapping and the frequency of the arch's vibrations about its final equilibrium state. We show that the growth rate of the snap-through instability and its subsequent ringing frequency can both be interpreted physically as the result of a sound wave in the material propagating over a distance comparable to the length of the arch. Finally, we extend our analysis of the ringing frequency of indented arches to understand the `pop' heard when everted shell structures snap-through to their stable state. Remarkably, we find that not only are the scaling laws for the ringing frequencies in these two scenarios identical but also the respective prefactors are numerically close; this allows us to develop a master curve for the frequency of ringing in snapping beams and shells.

Anupam Pandey; Derek E. Moulton; Dominic Vella; Douglas P. Holmes

2014-02-20T23:59:59.000Z

248

Jump to first page Promoting Health,  

E-Print Network [OSTI]

- sarcopenia Keller, 2003; McGarry, 2002; Ong, 2000; Barker, 1995; Law, 1996; Neel, 1962; Tappy, 2006; Hyponen

249

Stimulative Effects of Estrogens on Tumor Growth and 5?-Steroid Production in a Mouse Leydig Cell Tumor Line (T 124958-R)  

Science Journals Connector (OSTI)

...cells were harvested by a rubber policeman at the indicated...conditions used, the rate of production of 5 -or 17/3-hydroxy...FEBRUARY 1986 574 5 -ANDROGEN PRODUCTION IN MOUSE LEYDIG CELL TUMOR...FEBRUARY 1986 575 5a-ANDROGEN PRODUCTION IN MOUSE LEYDIG CELL TUMOR...

Shinzaburo Noguchi; Yasuko Nishizawa; Daishiro Takatsuka; Bunzo Sato; and Keishi Matsumoto

1986-02-01T23:59:59.000Z

250

Effect of Preirradiation of the Tumor Bed on the Relative Vascular Space of Mouse Gastric Adenocarcinoma 328 and Mammary Adenocarcinoma CA755  

Science Journals Connector (OSTI)

...viable portions of tumors of the MTG-B strain show an accelerating...not reflect the fundamental processes occurring in those areas of...Growth and Cell Loss in the MTG-B Mouse Mammary Carcinoma...of Mouse Mammary Tumor Strain MTG-B. Proc. Soc. Exptl. Biol...

Randy Jirtle and Kelly H. Clifton

1973-04-01T23:59:59.000Z

251

Natural history and karyology of the Yucatn vesper mouse, Otonyctomys hatti  

E-Print Network [OSTI]

Seventeen specimens of the rare Yucatn vesper mouse, Otonyctomys hatti, are now known from Belize, Guatemala, and the Mexican states of Campeche, Quintana Roo, and Yucatn. We herein report a second specimen of O. hatti, from Belize, extending the known geographic range of the species 95 km to the southeast in the country. This is the first location at which O. hatti has been taken sympatrically with the Central American vesper mouse, Nyctomys sumichrasti. We also report data on three additional specimens of O. hatti from Campeche. Nyctomys and Otonyctomys share similar habits and habitat requirements, and might compete where they overlap. However, the distribution of O. hatti corresponds closely to that of other Yucatn endemics, and the distinct distributions of the two genera probably reflects biogeographic history and different habitat requirements, rather than result from direct competition. The karyotype of O. hatti is 2n = 50, FN = 58. Although superficially similar, it differs in important respects with the karyotypes reported for N. sumichrasti....Resumen--Diescisiete especmenes del ratn Otonyctomys hatti, especie rara de Yucatn, son ahora conocidos de Belice, Guatemala y los Estados de Campeche, Quintana Roo y Yucatn. Aqu, informamos de un segundo especmen de O. hatti de Belice...

Genoways, Hugh H.; Timm, Robert M.; Engstrom, Mark D.

2005-01-01T23:59:59.000Z

252

Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse  

Science Journals Connector (OSTI)

HIV-Tat protein has been implicated in the pathogenesis of HIV-1 neurological complications (i.e., neuroAIDS), but direct demonstrations of the effects of Tat on behavior are limited. GT-tg mice with a doxycycline (Dox)-inducible and brain-selective tat gene coding for Tat protein were used to test the hypothesis that the activity of Tat in brain is sufficient to impair learning and memory processes. Western blot analysis of GT-tg mouse brains demonstrated an increase in Tat antibody labeling that seemed to be dependent on the dose and duration of Dox pretreatment. Dox-treated GT-tg mice tested in the Barnes maze demonstrated longer latencies to find an escape hole and displayed deficits in probe trial performance versus uninduced GT-tg littermates, suggesting Tat-induced impairments of spatial learning and memory. Reversal learning was also impaired in Tat-induced mice. Tat-induced mice additionally demonstrated long-lasting (up to one month) deficiencies in novel object recognition learning and memory performance. Furthermore, novel object recognition impairment was dependent on the dose and duration of Dox exposure, suggesting that Tat exposure progressively mediated deficits. These experiments provide evidence that Tat protein expression is sufficient to mediate cognitive abnormalities seen in HIV-infected individuals. Moreover, the genetically engineered GT-tg mouse may be useful for improving our understanding of the neurological underpinnings of neuroAIDS-related behaviors.

Amanda N. Carey; Elizabeth I. Sypek; Harminder D. Singh; Marc J. Kaufman; Jay P. McLaughlin

2012-01-01T23:59:59.000Z

253

Manuscript Version 6. Official copy "Mouse" in Berkshire Encyclopedia of Human-Computer Interaction, W.S. Bainbridge (ed). 2004 by Berkshire Publishing Group. http://www.berkshirepublishing.com/brw/BerkProd.asp?projID=29#  

E-Print Network [OSTI]

interface and many other innovations. There are various possible alternatives to the mouse, including touch is that for interacting with graphical user interfaces (GUI) on desktop computers, the mouse serves most users quite well two orthogonal optical encoders for two dimensional movements. Figure 2 shows the inside of a mouse

Zhai, Shumin

254

15 May 09 52MUniversity College London 4.4.11 rack 1Mouse Health Monitoring Report  

E-Print Network [OSTI]

15 May 09 52MUniversity College London 4.4.11 rack 1Mouse Test Date Health Monitoring ReportServ@harlan.com #12;15 May 09 52MUniversity College London 4.4.11 rack 1BMouse Test Date Health Monitoring Report

Richardson, William D.

255

Sulforaphane induces phase II detoxication enzymes in mouse skin and prevents mutagenesis induced by a mustard gas analog  

SciTech Connect (OSTI)

Mustard gas, used in chemical warfare since 1917, is a mutagenic and carcinogenic agent that produces severe dermal lesions for which there are no effective therapeutics; it is currently seen as a potential terrorist threat to civilian populations. Sulforaphane, found in cruciferous vegetables, is known to induce enzymes that detoxify compounds such as the sulfur mustards that react through electrophilic intermediates. Here, we observe that a single topical treatment with sulforaphane induces mouse epidermal levels of the regulatory subunit of glutamate-cysteine ligase, the rate-limiting enzyme in glutathione biosynthesis, and also increases epidermal levels of reduced glutathione. Furthermore, a glutathione S-transferase, GSTA4, is also induced in mouse skin by sulforaphane. In an in vivo model in which mice are given a single mutagenic application of the sulfur mustard analog 2-(chloroethyl) ethyl sulfide (CEES), we now show that therapeutic treatment with sulforaphane abolishes the CEES-induced increase in mutation frequency in the skin, measured four days after exposure. Sulforaphane, a natural product currently in clinical trials, shows promise as an effective therapeutic against mustard gas. -- Highlights: ? Sulforaphane induces increased levels of glutathione in mouse skin. ? Sulforaphane induces increased levels of GSTA4 in mouse skin. ? Sulforaphane, applied after CEES-treatment, completely abolishes CEES-mutagenesis. ? The therapeutic effect may suggest a long biological half-life for CEES in vivo.

Abel, E.L. [Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957 (United States)] [Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957 (United States); Boulware, S. [Division of Pharmacy and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd., Austin, TX 78723 (United States)] [Division of Pharmacy and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd., Austin, TX 78723 (United States); Fields, T.; McIvor, E.; Powell, K.L. [Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957 (United States)] [Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957 (United States); DiGiovanni, J.; Vasquez, K.M. [Division of Pharmacy and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd., Austin, TX 78723 (United States)] [Division of Pharmacy and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd., Austin, TX 78723 (United States); MacLeod, M.C., E-mail: mcmacleod@mdanderson.org [Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957 (United States)

2013-02-01T23:59:59.000Z

256

Intervening sequences divide the gene for the constant region of mouse immunoglobulin mu chains into segments, each encoding a domain  

Science Journals Connector (OSTI)

...mouse Au constant region (25). We prepared restriction frag- merits of the cloned cDNA as probes for specific portions of the V...provided a 3'-Cg specific probe. Fragments were labeled by nick translation (31). E L H76 NW *0 -12.5 -10 ,W - 7...

N M Gough; D J Kemp; B M Tyler; J M Adams; S Cory

1980-01-01T23:59:59.000Z

257

``In-bone'' Utricle CulturesVA Simplified, Atraumatic Technique for In Situ Cultures of the Adult Mouse  

E-Print Network [OSTI]

effectively in stud- ies of hair cell regeneration and hair cell death, as well as various agents that protect and protection. Background: The current in vitro technique for studying hair cells of the mature mouse utricle to the protective drug tacrine resulted in sig- nificant protection against neomycin (p G 0.05, 3-way analysis

Rubel, Edwin

258

3D segmentation of mouse organs from MR images using deformable simplex mesh models G. Hamarneh1  

E-Print Network [OSTI]

3D segmentation of mouse organs from MR images using deformable simplex mesh models G. Hamarneh1 , H. Delingette2 , M. Henkelman1 1 Hospital for Sick Children, Toronto, ON, Canada, 2 INRIA brains and kidneys from MR images. Algorithmic details and 3D segmentation results are presented

Hamarneh, Ghassan

259

Cell, Vol. 69, 1097-l 106, June 26, 1992, Copyright 0 1992 by Cell Press Gastrulation in the Mouse  

E-Print Network [OSTI]

the three germ layers- ectoderm, mescderm, and endoderm-are generated dur- ing animal development. After that glves rise to the head process. Treatment of early mouse embryos wlth activin results in goosecoid m gastrulation is completed, most vertebrate embryos have a remarkably similar body plan (von Baer, 1828

Blumberg, Bruce

260

High concentrations of morphine sensitize and activate mouse dorsal root ganglia via TRPV1 and TRPA1 receptors  

E-Print Network [OSTI]

and sensitized the release evoked by heat or the TRPA1 agonist acrolein. Morphine activated HEK293t cells transfected with TRPV1 or TRPA1. Activation of C57BL/6 mouse dorsal root ganglion neurons in culture was investigated with calcium imaging. Morphine induced...

Forster, Alexander B; Reeh, Peter; Messlinger, Karl; Fischer, Michael J M

2009-04-16T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Whole Slide Image Analysis Quantification using Aperio Digital Imaging in a Mouse Lung Metastasis Ronne L. Surface2  

E-Print Network [OSTI]

Whole Slide Image Analysis Quantification using Aperio Digital Imaging in a Mouse Lung Metastasis, Indiana University School of Medicine Digital whole slide imaging is the technique of digitizing a microscope slide at the highest resolution to produce a "digital virtual microscope slide". This digital

Zhou, Yaoqi

262

Mislocalization and Degradation of Human P23H-Rhodopsin-GFP in a Knockin Mouse Model of  

E-Print Network [OSTI]

in the inner segments of the frog rod cells, but does not form aggregates.9 Retention of P23HMislocalization and Degradation of Human P23H-Rhodopsin-GFP in a Knockin Mouse Model of Retinitis the effects of treatments on degradation and mislo- calization of proline-to-histidine change at codon 23 (P23

Wensel, Theodore G.

263

Bioactivation of food genotoxicants 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study  

Science Journals Connector (OSTI)

5-Hydroxymethylfurfural (HMF) and furfuryl alcohol (FFA)...k cat/K M) of HMF sulfoconjugation of human SULT1A1 (13.7s?1M?1), mouse Sult1a1 (15.8s?1M?1) and 1d1 (4.8s?1M?1) and r...

Benjamin Sachse; Walter Meinl; Yasmin Sommer; Hansruedi Glatt

2014-11-01T23:59:59.000Z

264

Low-Dose Ionizing Radiation Alters the Epigenome of the Avy Mouse  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Ionizing Radiation Alters the Epigenome of the A Ionizing Radiation Alters the Epigenome of the A vy Mouse Autumn Bernal 1,2,3 , Dale Huang 1 , Yue Li 4 , Dana Dolinoy 5 , and Randy Jirtle 1 Department of Radiation Oncology 1 , University Program in Genetics and Genomic 2 , Integrated Toxicology & Environmental Health Program 3 , Department of Community and Family Medicine 4 , Duke University Medical Center, Durham, NC, USA, Department of Environmental and Health Sciences, University of Michigan, Ann Arbor, MI, USA 4 Background: Humans have evolved and thrived amidst constant low-dose (0-10 cGy) background radiation exposure from natural sources. Currently, however, the frequency of exposures to low doses of radiation is increasing due to man-made sources such as diagnostic imaging and nuclear power. This increased exposure has led to concerns amongst the general public and the government about the

265

A simple, low-cost, data logging pendulum built from a computer mouse  

SciTech Connect (OSTI)

Lessons and homework problems involving a pendulum are often a big part of introductory physics classes and laboratory courses from high school to undergraduate levels. Although laboratory equipment for pendulum experiments is commercially available, it is often expensive and may not be affordable for teachers on fixed budgets, particularly in developing countries. We present a low-cost, easy-to-build rotary sensor pendulum using the existing hardware in a ball-type computer mouse. We demonstrate how this apparatus may be used to measure both the frequency and coefficient of damping of a simple physical pendulum. This easily constructed laboratory equipment makes it possible for all students to have hands-on experience with one of the most important simple physical systems.

Gintautas, Vadas [Los Alamos National Laboratory; Hubler, Alfred [UIUC

2009-01-01T23:59:59.000Z

266

Purification and characterization of mouse DNA polymerase ? devoid of primase activity  

Science Journals Connector (OSTI)

A simple method was developed for the isolation of primase-free DNA polymerase-? from the DNA polymerase-?-primase complex of mouse FM3A cells. The polymerase was separated from primase submits by chromatography on a single-stranded DNA-cellulose column in the presence of 50% etylene glycol. The primase-free DNA polymerase-? contained two polypeptides with molecular masses of 180000 and 68000. Analysis of the DNA products with poly(dA)-oligo(dT)10 as template-primer revealed that both primase-free DNA polymerase-? and the DNA polymerase-?-primase complex predominantly synthesized short DNA with less than 30 nucleotides, but that the DNA polymerase-?-primase complex also synthesized some longer DNA with more than 300400 nucleotides.

Ritsuko Takada-Takayama; Masashi Suzuki; Takemi Enomoto; Fumio Hanaoka; Michio Ui

1990-01-01T23:59:59.000Z

267

Triclosan induces Fas receptor-dependent apoptosis in mouse neocortical neurons in vitro  

Science Journals Connector (OSTI)

Abstract Triclosan (TCS) is a commonly used antimicrobial agent in personal care and sanitizing products, as well as in household items. Numerous studies have demonstrated the presence of TCS in various human tissues. Several studies have reported the accumulation of TCS in fish and human brain tissue. The aim of the present study was to investigate the effect of TCS on apoptosis in mouse neocortical neurons after 7days of culture in vitro following 3, 6 and 24h of exposure. To explore the mechanism underlying the effects of TCS in neurons, we studied the activation and protein expression of the Fas receptor (FasR) and caspase-8, caspase-9 and caspase-3, as well as DNA fragmentation in TCS-treated cells. Cultures of neocortical neurons were prepared from Swiss mouse embryos on day 15/16 of gestation. The cells were cultured in phenol red-free Neurobasal medium with B27 and glutamine. The cultures were treated with concentrations of TCS ranging from 1nM to 100?M for 3, 6 and 24h. The level of lactate dehydrogenase (LDH) was measured in the culture medium to exclude the cytotoxic concentrations. The cytotoxic effects were only observed when the highest concentrations of TCS were used (50 and 100?M). To study apoptosis, the activities of caspase-8, caspase-9 and caspase-3 were measured, and DNA fragmentation was evaluated. Our results are the first time to demonstrate that TCS can induce an apoptotic process in neocortical neurons in vitro. The data demonstrated that TCS caused caspase-3 activation, DNA fragmentation and apoptotic body formation. Non-cytotoxic concentrations of TCS activated the extrinsic apoptotic signaling pathway, which is dependent on FasR and caspase-8 activation. However, it is also possible that TCS may activate the intrinsic apoptotic pathway after long-term exposure. Therefore, further studies on the mechanism underlying the effects of TCS on the nervous system are needed.

K.A. Szychowski; A.M. Sitarz; A.K. Wojtowicz

2015-01-01T23:59:59.000Z

268

A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust  

Science Journals Connector (OSTI)

Background Most asthma begins in the first years of life. This early onset cannot be attributed merely to genetic factors because the prevalence of asthma is increasing. Epidemiologic studies have indicated roles for prenatal and early childhood exposures, including exposure to diesel exhaust. However, little is known about the mechanisms. This is largely due to a paucity of animal models. Objective We aimed to develop a mouse model of asthma susceptibility through prenatal exposure to diesel exhaust. Methods Pregnant C57BL/6 female mice were given repeated intranasal applications of diesel exhaust particles (DEPs) or PBS. Offspring underwent suboptimal immunization and challenge with ovalbumin (OVA) or received PBS. Pups were examined for features of asthma; lung and liver tissues were analyzed for transcription of DEP-regulated genes. Results Offspring of mice exposed to \\{DEPs\\} were hypersensitive to OVA, as indicated by airway inflammation and hyperresponsiveness, increased serum OVA-specific IgE levels, and increased pulmonary and systemic TH2 and TH17 cytokine levels. These cytokines were primarily produced by natural killer (NK) cells. Antibody-mediated depletion of NK cells prevented airway inflammation. Asthma susceptibility was associated with increased transcription of genes known to be specifically regulated by the aryl hydrocarbon receptor and oxidative stress. Features of asthma were either marginal or absent in OVA-treated pups of PBS-exposed mice. Conclusion We created a mouse model that linked maternal exposure to \\{DEPs\\} with asthma susceptibility in offspring. Development of asthma was dependent on NK cells and associated with increased transcription from aryl hydrocarbon receptor and oxidative stressregulated genes.

Sarah Manners; Rafeul Alam; David A. Schwartz; Magdalena M. Gorska

2014-01-01T23:59:59.000Z

269

Visualization of nitric oxide production in the mouse main olfactory bulb by a cell-trappable copper(II) fluorescent probe  

E-Print Network [OSTI]

We report the visualization of NO production using fluorescence in tissue slices of the mouse main olfactory bulb. This discovery was possible through the use of a novel, cell-trappable probe for intracellular nitric oxide ...

McQuade, Lindsey E.

270

Kinematics and Mechanics of Jumping Lizards: the Modulation of Jump Power  

E-Print Network [OSTI]

Physiology 271, C571-C578. Marsh, R. L. and John-Alder, H.Biol. Sci. Roberts, T. J. , Marsh, R. L. , Weyand, P. G. and

Olberding, Jeffrey Paul

2013-01-01T23:59:59.000Z

271

A mutation in the envelope protein fusion loop attenuates mouse neuroinvasiveness of the NY99 strain of West Nile virus  

SciTech Connect (OSTI)

Substitutions were engineered individually and in combinations at the fusion loop, receptor-binding domain and a stem-helix structure of the envelope protein of a West Nile virus strain, NY99, and their effects on mouse virulence and presentation of epitopes recognized by monoclonal antibodies (MAbs) were assessed. A single substitution within the fusion loop (L107F) attenuated mouse neuroinvasiveness of NY99. No substitutions attenuated NY99 neurovirulence. The L107F mutation also abolished binding of a non-neutralizing MAb, 3D9, whose epitope had not been previously identified. MAb 3D9 was subsequently shown to be broadly cross-reactive with other flaviviruses, consistent with binding near the highly conserved fusion loop.

Zhang Shuliu [Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555 (United States); Li Li; Woodson, Sara E. [Department of Pathology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555 (United States); Huang, Claire Y.-H.; Kinney, Richard M. [Arboviral Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Fort Collins, CO (United States); Barrett, Alan D.T. [Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555 (United States)]|[Department of Pathology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555 (United States)]|[Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555 (United States)]|[Sealy Center for Vaccine Development, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555 (United States)]|[Institute for Human Infections and Immunity, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555 (United States); Beasley, David W.C. [Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555 (United States)]|[Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555 (United States)]|[Sealy Center for Vaccine Development, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555 (United States)]|[Institute for Human Infections and Immunity, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555 (United States)]. E-mail: d.beasley@utmb.edu

2006-09-15T23:59:59.000Z

272

Tissue distribution of the dystrophin-related gene product and expression in the mdx and dy mouse  

SciTech Connect (OSTI)

The authors have previously reported a dystrophin-related locus (DMDL for Duchenne muscular dystrophy-like) on human chromosome 6 that maps close to the dy mutation on mouse chromosome 10. Here they show that this gene is expressed in a wide range of tissues at varying levels. The transcript is particularly abundant in several human fetal tissues, including heart, placenta, and intestine. Studies with antisera raised against a DMDL fusion protein identify a 400,000 M{sub r} protein in all mouse tissues tested, including those of mdx and dy mice. Unlike the dystrophin gene, the DMDL gene transcript is not differentially spliced at the 3{prime} end in either fetal muscle or brain.

Love, D.R.; Marsden, R.F.; Bloomfield, J.F.; Davies, K.E. (John Radcliffe Hospital, Oxford (England)); Morris, G.E.; Ellis, J.M. (North East Wales Inst., Deeside, Wales (England)); Fairbrother, U.; Edwards, Y.H. (Univ. College London (England)); Slater, C.P. (Newcastle General Hospital, Newcastle-upon-Tyne (England)); Parry, D.J. (Univ. of Ottawa, Ontario (Canada))

1991-04-15T23:59:59.000Z

273

Proteomic profiling of brain cortex tissues in a Tau transgenic mouse model of Alzheimer's disease  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer A transgenic mouse model expressing NSE-htau23 was used. Black-Right-Pointing-Pointer 2D-gel electrophoresis to analyze the cortex proteins of transgenic mice was used. Black-Right-Pointing-Pointer Differentially expressed spots in different stages of AD were identified. Black-Right-Pointing-Pointer GSTP1 and CAII were downregulated with the progression of AD. Black-Right-Pointing-Pointer SCRN1 and ATP6VE1 were up regulated and down regulated differentially. -- Abstract: Alzheimer's disease (AD) involves regionalized neuronal death, synaptic loss, and an accumulation of intracellular neurofibrillary tangles and extracellular senile plaques. Although there have been numerous studies on tau proteins and AD in various stages of neurodegenerative disease pathology, the relationship between tau and AD is not yet fully understood. A transgenic mouse model expressing neuron-specific enolase (NSE)-controlled human wild-type tau (NSE-htau23), which displays some of the typical Alzheimer-associated pathological features, was used to analyze the brain proteome associated with tau tangle deposition. Two-dimensional electrophoresis was performed to compare the cortex proteins of transgenic mice (6- and 12-month-old) with those of control mice. Differentially expressed spots in different stages of AD were identified with ESI-Q-TOF (electrospray ionization quadruple time-of-flight) mass spectrometry and liquid chromatography/tandem mass spectrometry. Among the identified proteins, glutathione S-transferase P 1 (GSTP1) and carbonic anhydrase II (CAII) were down-regulated with the progression of AD, and secerin-1 (SCRN1) and V-type proton ATPase subunit E 1 (ATP6VE1) were up-regulated only in the early stages, and down-regulated in the later stages of AD. The proteins, which were further confirmed by RT-PCR at the mRNA level and with western blotting at the protein level, are expected to be good candidates as drug targets for AD. The study of up- and down-regulation of proteins during the progression of AD helps to explain the mechanisms associated with neuronal degeneration in AD.

Chang, Seong-Hun; Jung, In-Soo; Han, Gi-Yeon; Kim, Nam-Hee; Kim, Hyun-Jung [School of Life Sciences and Biotechnology, Korea University, Seoul 136-701 (Korea, Republic of)] [School of Life Sciences and Biotechnology, Korea University, Seoul 136-701 (Korea, Republic of); Kim, Chan-Wha, E-mail: cwkim@korea.ac.kr [School of Life Sciences and Biotechnology, Korea University, Seoul 136-701 (Korea, Republic of)] [School of Life Sciences and Biotechnology, Korea University, Seoul 136-701 (Korea, Republic of)

2013-01-11T23:59:59.000Z

274

Induction of chloride secretory currents across mouse ileal tissues by rotavirus enterotoxic peptide in different age mice  

E-Print Network [OSTI]

INDUCTION OF CHLORIDE SECRETORY CURRENTS ACROSS MOUSE ILEAL TISSUES BY A ROTAVIRUS ENTEROTOXIC PEPTIDE IN DIFFERENT AGE MICE A Thesis by VIRGINIA WATERS COX Submitted to the Office of Graduate Studies of Texas Ak M University in partial... by VIRGINIA WATERS COX Submitted to Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved as to style and content by: Judith M. Ball (Chair of Committee) Julian Lei os z (Member) Friedhelm...

Cox, Virginia Waters

2002-01-01T23:59:59.000Z

275

Effects of dietary eicosapentaenoic acid and docosahexaenoic acid on mouse T-lymphocyte function and diglyceride formation  

E-Print Network [OSTI]

. Edwards (Interim Department Head) December 1992 ABSTRACT Effects of Dietary Eicosapentaenoic Acid and Docosahexaenoic Acid on Mouse T-Lymphocyte Function and Diglyceride Formation. (December 1992) Kara Hosack Fowler, B. S. , Texas A&%M University..., coupled to CD3, a mediator which acts in stimulation to bind to phospholipase C (PLC) (10). Mitogens act on the TCR-CD3 complex to stimulate phospholipase C and hydrolysis of phosphatidylinositol (100). This results in diacylglycerol (DAG) and inositol...

Fowler, Kara Hosack

1992-01-01T23:59:59.000Z

276

Multi-walled carbon nanotube-induced gene expression in the mouse lung: Association with lung pathology  

SciTech Connect (OSTI)

Due to the fibrous shape and durability of multi-walled carbon nanotubes (MWCNT), concerns regarding their potential for producing environmental and human health risks, including carcinogenesis, have been raised. This study sought to investigate how previously identified lung cancer prognostic biomarkers and the related cancer signaling pathways are affected in the mouse lung following pharyngeal aspiration of well-dispersed MWCNT. A total of 63 identified lung cancer prognostic biomarker genes and major signaling biomarker genes were analyzed in mouse lungs (n = 80) exposed to 0, 10, 20, 40, or 80 {mu}g of MWCNT by pharyngeal aspiration at 7 and 56 days post-exposure using quantitative PCR assays. At 7 and 56 days post-exposure, a set of 7 genes and a set of 11 genes, respectively, showed differential expression in the lungs of mice exposed to MWCNT vs. the control group. Additionally, these significant genes could separate the control group from the treated group over the time series in a hierarchical gene clustering analysis. Furthermore, 4 genes from these two sets of significant genes, coiled-coil domain containing-99 (Ccdc99), muscle segment homeobox gene-2 (Msx2), nitric oxide synthase-2 (Nos2), and wingless-type inhibitory factor-1 (Wif1), showed significant mRNA expression perturbations at both time points. It was also found that the expression changes of these 4 overlapping genes at 7 days post-exposure were attenuated at 56 days post-exposure. Ingenuity Pathway Analysis (IPA) found that several carcinogenic-related signaling pathways and carcinogenesis itself were associated with both the 7 and 11 gene signatures. Taken together, this study identifies that MWCNT exposure affects a subset of lung cancer biomarkers in mouse lungs. - Research Highlights: > Multi-Walled Carbon Nanotubes affect lung cancer biomarkers in mouse lungs. > The results suggest potentially harmful effects of MWCNT exposure on human lungs. > The results could potentially be used for the medical surveillance of workers.

Pacurari, M. [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Qian, Y., E-mail: yaq2@cdc.gov [Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Porter, D.W.; Wolfarth, M. [Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Wan, Y.; Luo, D. [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Ding, M. [Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Castranova, V. [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Guo, N.L., E-mail: lguo@hsc.wvu.edu [Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506-9300 (United States); Department of Community Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506-9190 (United States)

2011-08-15T23:59:59.000Z

277

A physiologically based pharmacokinetic model for atrazine and its main metabolites in the adult male C57BL/6 mouse  

SciTech Connect (OSTI)

Atrazine (ATR) is a chlorotriazine herbicide that is widely used and relatively persistent in the environment. In laboratory rodents, excessive exposure to ATR is detrimental to the reproductive, immune, and nervous systems. To better understand the toxicokinetics of ATR and to fill the need for a mouse model, a physiologically based pharmacokinetic (PBPK) model for ATR and its main chlorotriazine metabolites (Cl-TRIs) desethyl atrazine (DE), desisopropyl atrazine (DIP), and didealkyl atrazine (DACT) was developed for the adult male C57BL/6 mouse. Taking advantage of all relevant and recently made available mouse-specific data, a flow-limited PBPK model was constructed. The ATR and DACT sub-models included blood, brain, liver, kidney, richly and slowly perfused tissue compartments, as well as plasma protein binding and red blood cell binding, whereas the DE and DIP sub-models were constructed as simple five-compartment models. The model adequately simulated plasma levels of ATR and Cl-TRIs and urinary dosimetry of Cl-TRIs at four single oral dose levels (250, 125, 25, and 5 mg/kg). Additionally, the model adequately described the dose dependency of brain and liver ATR and DACT concentrations. Cumulative urinary DACT amounts were accurately predicted across a wide dose range, suggesting the model's potential use for extrapolation to human exposures by performing reverse dosimetry. The model was validated using previously reported data for plasma ATR and DACT in mice and rats. Overall, besides being the first mouse PBPK model for ATR and its Cl-TRIs, this model, by analogy, provides insights into tissue dosimetry for rats. The model could be used in tissue dosimetry prediction and as an aid in the exposure assessment to this widely used herbicide.

Lin Zhoumeng [Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602 (United States); Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602 (United States); Fisher, Jeffrey W. [Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602 (United States); Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA 30602 (United States); Ross, Matthew K. [Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762 (United States); Filipov, Nikolay M., E-mail: filipov@uga.edu [Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602 (United States); Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602 (United States)

2011-02-15T23:59:59.000Z

278

Effect of mechanical processing and heat treatment of powders on their sinterability characteristics linked with their method of manufacture. IV. The v/v vs tau function in a temperature jump in the sintering of porous bodies from molybdenum and tungsten carbide powders  

SciTech Connect (OSTI)

Use was made of molybdenum and tungsten carbide powders, which exhibit fairly high densification rates. The main object of the sintering of specimens from a molybdenum powder was to find out to what extent the behavior in a temperature jump of a metal differing markedly in physical properties (and electronic shell structure) from the metals investigated earlier resembled or differed from that of those metals. A molybdenum powder produced by the reduction of molybdenum trioxide with hydrogen at 800 C was chosen for investigation and experiments with tungsten carbide were carried out on two batches of powders produced at low and high carbidization temperatures. The study showed that the behavior of a porous specimen from the molybdenum powder did not differ from that of other metal powders. The behavior of tungsten carbide specimens in a temperature jump was similar to that of the metal powders studied in a previous investigation.

Ivensen, V.A.

1986-04-01T23:59:59.000Z

279

A comparison of the metabolism of HEOD (dieldrin) in the CF1 mouse with that in the CFE rat  

Science Journals Connector (OSTI)

HEOD labelled with 14C was administered to CFE rats and CF1 mice and the excreted radioactivity was examined to characterize the various HEOD metabolites. In addition to the pentachloroketone and 9-hydroxy metabolites, the identities of two further metabolites of HEOD in the rat were established. These are a faecal metabolite, 6,7-trans-dihydroaldrindiol, and a urinary metabolite, the hexachlorohexahydromethanoindene-dicarboxylic acid, which may be formed by oxidation of the diol. Three of the rat metabolites, but not the pentachloroketone, were found in the excreta of the CF1 mouse. Where possible the quantity of radio-activity present as any given metabolite was determined. A sample of the new urinary metabolite of the rat was synthesized and shown to have an acute oral toxicity of >850 mg/kg in the CF1 mouse. Prior induction of enzyme activity appeared to affect the production of urinary metabolites of HEOD in the CFE rat but not in the CF1 mouse.

M.K. Baldwin; J. Robinson; D.V. Parke

1972-01-01T23:59:59.000Z

280

Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate  

SciTech Connect (OSTI)

Pretreatment of mice with the peroxisome proliferator clofibrate (CFB) protects against acetaminophen (APAP)-induced hepatotoxicity. Previous studies have shown that activation of the nuclear peroxisome proliferator activated receptor-alpha (PPAR{alpha}) is required for this effect. The present study utilizes gene expression profile analysis to identify potential pathways contributing to PPAR{alpha}-mediated hepatoprotection. Gene expression profiles were compared between wild type and PPAR{alpha}-null mice pretreated with vehicle or CFB (500 mg/kg, i.p., daily for 10 days) and then challenged with APAP (400 mg/kg, p.o.). Total hepatic RNA was isolated 4 h after APAP treatment and hybridized to Affymetrix Mouse Genome MGU74 v2.0 GeneChips. Gene expression analysis was performed utilizing GeneSpring (registered) software. Our analysis identified 53 genes of interest including vanin-1, cell cycle regulators, lipid-metabolizing enzymes, and aldehyde dehydrogenase 2, an acetaminophen binding protein. Vanin-1 could be important for CFB-mediated hepatoprotection because this protein is involved in the synthesis of cysteamine and cystamine. These are potent antioxidants capable of ameliorating APAP toxicity in rodents and humans. HPLC-ESI/MS/MS analysis of liver extracts indicates that enhanced vanin-1 gene expression results in elevated cystamine levels, which could be mechanistically associated with CFB-mediated hepatoprotection.

Moffit, Jeffrey S. [University of Connecticut, Department of Pharmaceutical Sciences, Storrs, CT (United States); Koza-Taylor, Petra H. [Pfizer, Inc., Groton Laboratories, Molecular and Investigative Toxicology, Groton, CT (United States); Holland, Ricky D. [National Center for Toxicological Research, Division of Systems Toxicology, Jefferson, AR (United States); Thibodeau, Michael S. [University of Connecticut, Department of Pharmaceutical Sciences, Storrs, CT (United States); Beger, Richard D. [National Center for Toxicological Research, Division of Systems Toxicology, Jefferson, AR (United States); Lawton, Michael P. [Pfizer, Inc., Groton Laboratories, Molecular and Investigative Toxicology, Groton, CT (United States); Manautou, Jose E. [University of Connecticut, Department of Pharmaceutical Sciences, Storrs, CT (United States)]. E-mail: jose.manautou@uconn.edu

2007-07-15T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
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281

Alteration of mouse oocyte quality after a subchronic exposure to depleted Uranium  

Science Journals Connector (OSTI)

Gametes and embryo tissues are known to represent a sensitive target to environmental toxicants exposure. Oocyte quality can impact subsequent developmental competence, pregnancy course and even adult health. The major health concern from depleted uranium (DU) is mainly centred on its chemotoxic properties as a heavy metal. Little attention was paid to the impact of uranium on female gamete quality. The aim of this research was to evaluate the effect of DU on mouse oocyte quality after 49 days of subchronic contamination in drinking water and to correlate the observed effects with the amount of DU accumulated in organs. Four different DU concentrations were investigated: 0 (control), 10 (DU10), 20 (DU20) and 40mgL?1 (DU40). DU did not influence the intensity of ovulation but affected oocyte quality. The proportion of healthy oocytes was reduced by half (P<0.001) from 20mgL?1 compared with control group (0.537; 0.497; 0.282 and 0.239 in control, DU10, DU20 and DU40 groups respectively) whereas no accumulation of DU was recorded in the ovaries whatever the dose tested. Abnormal perivitelline space (P<0.001) or absence of the 1st polar body (P<0.001) was identified as the main characteristic of DU impact. In the context of this study, the NOAEL for oocyte quality was determined at 10mgL?1 in drinking water (1.9mgkg?1day?1). An increase in the dose of contamination over 20mgL?1 did not amplify the proportion of oocytes contracting a specific alteration but conducted to a diversification in oocytes abnormalities. Further investigations are necessary to correlate morphologic assessment of female gamete with its developmental competence.

Alexandre Feugier; Sandrine Frelon; Patrick Gourmelon; Marie Claraz

2008-01-01T23:59:59.000Z

282

HumanWildlife Conflicts 3(1):89, Spring 2009 The Soap Box  

E-Print Network [OSTI]

of controlling wildlife were (1) the field success of poison against meadow mice during a Nevada mouse plague not be transmissible to other vertebrates. Because this was not successful, it searched for a poison bait or lethal gas that any accurate knowledge of the food habits of such pests and effective means for reducing their numbers

283

Stable yeast transformants that secrete functional. cap alpha. -amylase encoded by cloned mouse pancreatic cDNA  

SciTech Connect (OSTI)

Mouse pancreatic ..cap alpha..-amylase complementary DNA was inserted into a yeast shuttle vector after the Saccharomyces cerevisiae MF..cap alpha..1 promoter and secretion signals coding sequences. When transformed with the recombinant plasmid, S. cerevisiae cells were able to synthesize and secrete functional ..cap alpha..-amylase, efficiently hydrolyzing starch present in the culture medium. Stable amylolytic cells were obtained from different yeast strains. This work represents a significant step towards producing yeast that can convert starchy materials directly to ethanol.

Filho, S.A.; Galembeck, E.V.; Faria, J.B.; Frascino, A.C.S.

1986-04-01T23:59:59.000Z

284

Hyperspectral imaging signatures detect amyloidopathy in Alzheimers mouse retina well before onset of cognitive decline  

Science Journals Connector (OSTI)

The technique was found useful for monitoring retinal and brain amyloidopathy in an ongoing preclinical anti-AD study, attesting to the techniques sensitivity and specificity. ... Interestingly, the technique was found applicable not just to excised brain tissue, but also to isolated mouse retina. ... With the retina being heralded widely as a (diagnostic) extension of the CNS and retinal amyloidopathy occurring well before that in the brain, this development raises a possibility for the first direct retinal imaging diagnosis of early, asymptomatic Alzheimers disease. ...

Swati Sudhakar More; Robert Vince

2014-10-29T23:59:59.000Z

285

Transient inhibition of cell proliferation does not compromise self-renewal of mouse embryonic stem cells  

SciTech Connect (OSTI)

Embryonic stem cells (ESCs) have unlimited capacity for self-renewal and can differentiate into various cell types when induced. They also have an unusual cell cycle control mechanism driven by constitutively active cyclin dependent kinases (Cdks). In mouse ESCs (mESCs). It is proposed that the rapid cell proliferation could be a necessary part of mechanisms that maintain mESC self-renewal and pluripotency, but this hypothesis is not in line with the finding in human ESCs (hESCs) that the length of the cell cycle is similar to differentiated cells. Therefore, whether rapid cell proliferation is essential for the maintenance of mESC state remains unclear. We provide insight into this uncertainty through chemical intervention of mESC cell cycle. We report here that inhibition of Cdks with olomoucine II can dramatically slow down cell proliferation of mESCs with concurrent down-regulation of cyclin A, B and E, and the activation of the Rb pathway. However, mESCs display can recover upon the removal of olomoucine II and are able to resume normal cell proliferation without losing self-renewal and pluripotency, as demonstrated by the expression of ESC markers, colony formation, embryoid body formation, and induced differentiation. We provide a mechanistic explanation for these observations by demonstrating that Oct4 and Nanog, two major transcription factors that play critical roles in the maintenance of ESC properties, are up-regulated via de novo protein synthesis when the cells are exposed to olomoucine II. Together, our data suggest that short-term inhibition of cell proliferation does not compromise the basic properties of mESCs. -- Highlights: Black-Right-Pointing-Pointer Inhibition of Cdks slows down mESCs proliferation. Black-Right-Pointing-Pointer mESCs display remarkable recovery capacity from short-term cell cycle interruption. Black-Right-Pointing-Pointer Short-term cell cycle interruption does not compromise mESC self-renewal. Black-Right-Pointing-Pointer Oct4 and Nanog are up-regulated via de novo synthesis by cell cycle interruption.

Wang, Ruoxing [Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive 5018, Hattiesburg, MS 39406 (United States)] [Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive 5018, Hattiesburg, MS 39406 (United States); Guo, Yan-Lin, E-mail: yanlin.guo@usm.edu [Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive 5018, Hattiesburg, MS 39406 (United States)] [Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive 5018, Hattiesburg, MS 39406 (United States)

2012-10-01T23:59:59.000Z

286

Slow elimination of phosphorylated histone {gamma}-H2AX from DNA of terminally differentiated mouse heart cells in situ  

SciTech Connect (OSTI)

Phosphorylation of replacement histone H2AX occurs in megabase chromatin domains around double-strand DNA breaks (DSBs) and this modification (called {gamma}-H2AX) may serve as a useful marker of genome damage and repair in terminally differentiated cells. Here using immunohistochemistry we studied kinetics of {gamma}-H2AX formation and elimination in the X-irradiated mouse heart and renal epithelial tissues in situ. Unirradiated tissues have 3-5% {gamma}-H2AX-positive cells and in tissues fixed 1 h after X-irradiation {gamma}-H2AX-positive nuclei are induced in a dose-dependent manner approaching 20-30% after 3 Gy of IR. Analysis of mouse tissues at different times after 3 Gy of IR showed that maximal induction of {gamma}-H2AX in heart is observed 20 min after IR and then is decreased slowly with about half remaining 23 h later. In renal epithelium maximum of the {gamma}-H2AX-positive cells is observed 40 min after IR and then decreases to control values in 23 h. This indicates that there are significant variations between non-proliferating mammalian tissues in the initial H2AX phosphorylation rate as well as in the rate of {gamma}-H2AX elimination after X-irradiation, which should be taken into account in the analysis of radiation responses.

Gavrilov, Boris [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation); Vezhenkova, Irina [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation); Firsanov, Denis [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation); Solovjeva, Liudmila [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation); Svetlova, Maria [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation); Mikhailov, Vyacheslav [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation); Tomilin, Nikolai [Institute of Cytology, Russian Academy of Sciences, 194064 St. Petersburg (Russian Federation)]. E-mail: nvtom@hotmail.com

2006-09-08T23:59:59.000Z

287

Susceptibility of Highly Pathogenic H5N1 Influenza Viruses to the Neuraminidase Inhibitor Oseltamivir Differs In Vitro and in a Mouse Model  

Science Journals Connector (OSTI)

...the proportional hazards model. e Loss or gain of weight...R. 1972. Regression models and life-tables. J...Kawaoka. 2005. Avian flu: isolation of drug-resistant...in vitro and in a mouse model. | While the neuraminidase...whether in vitro testing can predict the in vivo effectiveness...

Elena A. Govorkova; Natalia A. Ilyushina; Jennifer L. McClaren; Tri S. P. Naipospos; Bounlom Douangngeun; Robert G. Webster

2009-04-06T23:59:59.000Z

288

Rapid, automated imaging of mouse articular cartilage by microCT for early detection of osteoarthritis and finite element modelling of joint mechanics  

Science Journals Connector (OSTI)

SummaryObjective Mouse articular cartilage (AC) is mostly assessed by histopathology and its mechanics is poorly characterised. In this study: (1) we developed non-destructive imaging for quantitative assessment of AC morphology and (2) evaluated the mechanical implications of AC structural changes. Methods Knee joints obtained from nave mice and from mice with osteoarthritis (OA) induced by destabilization of medial meniscus (DMM) for 4 and 12 weeks, were imaged by phosphotungstic acid (PTA) contrast enhanced micro-computed tomography (PTA-CT) and scored by conventional histopathology. Our software (Matlab) automatically segmented tibial AC, drew two regions centred on each tibial condyle and evaluated the volumes included. A finite element (FE) model of the whole mouse joint was implemented to evaluate AC mechanics. Results Our method achieved rapid, automated analysis of mouse AC (structural parameters in simulations estimated that AC thinning at early-stages in the DMM model (4 weeks) increases contact pressures (+39%) and Tresca stresses (+43%) in AC. Conclusion PTA-CT imaging is a fast and simple method to assess OA in murine models. Once applied more extensively to confirm its robustness, our approach will be useful for rapidly phenotyping genetically modified mice used for OA research and to improve the current understanding of mouse cartilage mechanics.

P. Das Neves Borges; A.E. Forte; T.L. Vincent; D. Dini; M. Marenzana

2014-01-01T23:59:59.000Z

289

Mandibular and Neural Crest Cell Deficits Seen in TsDn65 Down Syndrome Mouse Model Rescued By Green Tea Polyphenol, EGCG  

E-Print Network [OSTI]

to the mandibular deficit seen in E9.5 Ts65Dn embryos. We propose that EGCG, a green tea polyphenol, will inhibitMandibular and Neural Crest Cell Deficits Seen in TsDn65 Down Syndrome Mouse Model Rescued By Green Tea Polyphenol, EGCG Gracelyn C. Bose1 , Rachel A. Novack1 ,Danika M. Tumbleson1 , Alexis N. Chom1

Zhou, Yaoqi

290

Local volume changes of the corpus callosum from 3D MR images of wildtype and knockout mouse brains G. Hamarneh1  

E-Print Network [OSTI]

CC from the MR images (Figure 1a) using Livewire, a semi-automatic segmentation tool provided by AmiraLocal volume changes of the corpus callosum from 3D MR images of wildtype and knockout mouse brains G. Hamarneh1 , J. Chen1 , N. Lifshitz1 , J. Henderson2 , M. Henkelman1 1 Hospital for Sick Children

Hamarneh, Ghassan

291

The Teratogenic Sensitivity to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Is Modified by a Locus on Mouse Chromosome 3  

E-Print Network [OSTI]

- phrosis in developing mice exposed to the pollutant 2,3,7,8- tetrachlorodibenzo-p-dioxin (dioxin) is a prototype for the study of gene-environment interactions. Dioxin is an ubiquitous environmental pollutantThe Teratogenic Sensitivity to 2,3,7,8-Tetrachlorodibenzo-p- dioxin Is Modified by a Locus on Mouse

Bradfield, Christopher A.

292

Direct and indirect impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)1 on adult mouse Leydig cells: an in vitro study.2  

E-Print Network [OSTI]

1 Direct and indirect impact of 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD)1 on adult mouse Leydig,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related substances are ubiquitous22 environmental pollutants that exert words: Dioxin; Leydig cell; in vitro; AhR; chemokine39 40 inserm-00816472,version1-22Apr2013 #12;3 1

Paris-Sud XI, Université de

293

Conversion of the Common Food Constituent 5-Hydroxymethylfurfural into a Mutagenic and Carcinogenic Sulfuric Acid Ester in the Mouse in Vivo  

Science Journals Connector (OSTI)

Conversion of the Common Food Constituent 5-Hydroxymethylfurfural into a Mutagenic and Carcinogenic Sulfuric Acid Ester in the Mouse in Vivo ... 5-Hydroxymethylfurfural (HMF), formed by acid-catalyzed dehydration and in the Maillard reaction from reducing sugars, is found at high levels in numerous foods. ... Hydroxymethylfurfural, A Versatile Platform Chemical Made from Renewable Resources ...

Bernhard H. Monien; Heinz Frank; Albrecht Seidel; Hansruedi Glatt

2009-04-22T23:59:59.000Z

294

DOI-BLM-NV-C010-2010-0008-CX | Open Energy Information  

Open Energy Info (EERE)

0-0008-CX 0-0008-CX Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home NEPA Document Collection for: DOI-BLM-NV-C010-2010-0008-CX CX at Dixie Meadows Geothermal Area for Geothermal/Exploration Dixie Meadows Seismic Survey General NEPA Document Info Energy Sector Geothermal energy Environmental Analysis Type CX Applicant Terra-Gen Power LLC Geothermal Area Dixie Meadows Geothermal Area Project Location Nevada Project Phase Geothermal/Exploration Techniques Electromagnetic Techniques Time Frame (days) Application Time 209 Participating Agencies Lead Agency BLM Funding Agency none provided Managing District Office Carson City Managing Field Office Stillwater Funding Agencies none provided Surface Manager BLM Mineral Manager BLM Selected Dates Application Date 6/30/2009

295

Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord  

E-Print Network [OSTI]

Defaults in vascular (VN) and neuronal networks of spinal cord are responsible for serious neurodegenerative pathologies. Because of inadequate investigation tools, the lacking knowledge of the complete fine structure of VN and neuronal systems is a crucial problem. Conventional 2D imaging yields incomplete spatial coverage leading to possible data misinterpretation, whereas standard 3D computed tomography imaging achieves insufficient resolution and contrast. We show that X-ray high-resolution phase-contrast tomography allows the simultaneous visualization of three-dimensional VN and neuronal systems of mouse spinal cord at scales spanning from millimeters to hundreds of nanometers, with neither contrast agent nor a destructive sample-preparation. We image both the 3D distribution of micro-capillary network and the micrometric nerve fibers, axon-bundles and neuron soma. Our approach is a crucial tool for pre-clinical investigation of neurodegenerative pathologies and spinal-cord-injuries. In particular, it s...

Fratini, Michela; Campi, Gaetano; Brun, Francesco; Tromba, Giuliana; Modregger, Peter; Bucci, Domenico; Battaglia, Giuseppe; Spadon, Raffaele; Mastrogiacomo, Maddalena; Requardt, Herwig; Giove, Federico; Bravin, Alberto; Cedola, Alessia

2014-01-01T23:59:59.000Z

296

Cyclic mechanical strain maintains Nanog expression through PI3K/Akt signaling in mouse embryonic stem cells  

SciTech Connect (OSTI)

Mechanical strain has been reported to affect the proliferation/differentiation of many cell types; however, the effects of mechanotransduction on self-renewal as well as pluripotency of embryonic stem (ES) cells remains unknown. To investigate the effects of mechanical strain on mouse ES cell fate, we examined the expression of Nanog, which is an essential regulator of self-renewal and pluripotency as well as Nanog-associated intracellular signaling during uniaxial cyclic mechanical strain. The mouse ES cell line, CCE was plated onto elastic membranes, and we applied 10% strain at 0.17 Hz. The expression of Nanog was reduced during ES cell differentiation in response to the withdrawal of leukemia inhibitory factor (LIF); however, two days of cyclic mechanical strain attenuated this reduction of Nanog expression. On the other hand, the cyclic mechanical strain promoted PI3K-Akt signaling, which is reported as an upstream of Nanog transcription. The cyclic mechanical strain-induced Akt phosphorylation was blunted by the PI3K inhibitor wortmannin. Furthermore, cytochalasin D, an inhibitor of actin polymerization, also inhibited the mechanical strain-induced increase in phospho-Akt. These findings imply that mechanical force plays a role in regulating Nanog expression in ES cells through the actin cytoskeleton-PI3K-Akt signaling. -- Highlights: Black-Right-Pointing-Pointer The expression of Nanog, which is an essential regulator of 'stemness' was reduced during embryonic stem (ES) cell differentiation. Black-Right-Pointing-Pointer Cyclic mechanical strain attenuated the reduction of Nanog expression. Black-Right-Pointing-Pointer Cyclic mechanical strain promoted PI3K-Akt signaling and mechanical strain-induced Akt phosphorylation was blunted by the PI3K inhibitor and an inhibitor of actin polymerization.

Horiuchi, Rie [Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033 (Japan)] [Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033 (Japan); Akimoto, Takayuki, E-mail: akimoto@m.u-tokyo.ac.jp [Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033 (Japan) [Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033 (Japan); Institute for Biomedical Engineering, Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Waseda-tsurumaki, Shinjuku, Tokyo 162-0041 (Japan); Hong, Zhang [Institute for Biomedical Engineering, Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Waseda-tsurumaki, Shinjuku, Tokyo 162-0041 (Japan)] [Institute for Biomedical Engineering, Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Waseda-tsurumaki, Shinjuku, Tokyo 162-0041 (Japan); Ushida, Takashi [Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033 (Japan)] [Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033 (Japan)

2012-08-15T23:59:59.000Z

297

A Novel mouse model of enhanced proteostasis: Full-length human heat shock factor 1 transgenic mice  

SciTech Connect (OSTI)

Research highlights: {yields} Development of mouse overexpressing native human HSF1 in all tissues including CNS. {yields} HSF1 overexpression enhances heat shock response at whole-animal and cellular level. {yields} HSF1 overexpression protects from polyglutamine toxicity and favors aggresomes. {yields} HSF1 overexpression enhances proteostasis at the whole-animal and cellular level. -- Abstract: The heat shock response (HSR) is controlled by the master transcriptional regulator heat shock factor 1 (HSF1). HSF1 maintains proteostasis and resistance to stress through production of heat shock proteins (HSPs). No transgenic model exists that overexpresses HSF1 in tissues of the central nervous system (CNS). We generated a transgenic mouse overexpressing full-length non-mutant HSF1 and observed a 2-4-fold increase in HSF1 mRNA and protein expression in all tissues studied of HSF1 transgenic (HSF1{sup +/0}) mice compared to wild type (WT) littermates, including several regions of the CNS. Basal expression of HSP70 and 90 showed only mild tissue-specific changes; however, in response to forced exercise, the skeletal muscle HSR was more elevated in HSF1{sup +/0} mice compared to WT littermates and in fibroblasts following heat shock, as indicated by levels of inducible HSP70 mRNA and protein. HSF1{sup +/0} cells elicited a significantly more robust HSR in response to expression of the 82 repeat polyglutamine-YFP fusion construct (Q82YFP) and maintained proteasome-dependent processing of Q82YFP compared to WT fibroblasts. Overexpression of HSF1 was associated with fewer, but larger Q82YFP aggregates resembling aggresomes in HSF1{sup +/0} cells, and increased viability. Therefore, our data demonstrate that tissues and cells from mice overexpressing full-length non-mutant HSF1 exhibit enhanced proteostasis.

Pierce, Anson, E-mail: piercea2@uthscsa.edu [Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States) [Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); The Department of Veteran's Affairs, South Texas Veterans Health Care System, San Antonio, Texas, 78284 (United States); Wei, Rochelle; Halade, Dipti [Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States)] [Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); Yoo, Si-Eun [Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States) [Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); Ran, Qitao; Richardson, Arlan [Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States) [Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 (United States); The Department of Veteran's Affairs, South Texas Veterans Health Care System, San Antonio, Texas, 78284 (United States)

2010-11-05T23:59:59.000Z

298

Functional Analysis of the Mouse Scn8a Sodium Channel Marianne R. Smith,1 Raymond D. Smith,1 Nicholas W. Plummer,2 Miriam H. Meisler,2 and Alan L. Goldin1  

E-Print Network [OSTI]

Functional Analysis of the Mouse Scn8a Sodium Channel Marianne R. Smith,1 Raymond D. Smith,1 modulate the electrophysiological properties of the channels (Isom et al., 1992, 1995; Smith and Goldin

Goldin, Alan L.

299

Genetic susceptibility to low-dose ionizing radiation in the mouse mammary glandas a means of understanding human risk for breast cancer  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

susceptibility to low-dose ionizing radiation in the mouse mammary gland susceptibility to low-dose ionizing radiation in the mouse mammary gland as a means of understanding human risk for breast cancer Antoine M. Snijders 1 , Francesco Marchetti 1 , Ju Han 1 , Sandhya Bhatnagar 1 , Nadire Duru 1 , Zhi Hu 1 , Jian-Hua Mao 1 , Mina Bissell 1 , Joe Gray 1,2 , Gary H. Karpen 1 , Priscilla K. Cooper 1 and Andrew J. Wyrobek 1 1 Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 2 Current affiliation: Biomedical Engineering, Oregon Health Science Univ, Portland, OR Goal: Our goal is to develop an in vivo mechanistic model of genetic variation in the low-dose damage responses of mammary glands using inbred mice known to vary in their sensitivity to low-dose induced mammary gland cancer, and to develop molecular predictors for susceptibility or resistance to low-dose induced breast cancer.

300

The role of renal proximal tubule P450 enzymes in chloroform-induced nephrotoxicity: Utility of renal specific P450 reductase knockout mouse models  

SciTech Connect (OSTI)

The kidney is a primary target for numerous toxic compounds. Cytochrome P450 enzymes (P450) are responsible for the metabolic activation of various chemical compounds, and in the kidney are predominantly expressed in proximal tubules. The aim of this study was to test the hypothesis that renal proximal tubular P450s are critical for nephrotoxicity caused by chemicals such as chloroform. We developed two new mouse models, one having proximal tubule-specific deletion of the cytochrome P450 reductase (Cpr) gene (the enzyme required for all microsomal P450 activities), designated proximal tubule-Cpr-null (PTCN), and the other having proximal tubule-specific rescue of CPR activity with the global suppression of CPR activity in all extra-proximal tubular tissues, designated extra-proximal tubule-Cpr-low (XPT-CL). The PTCN, XPT-CL, Cpr-low (CL), and wild-type (WT) mice were treated with a single oral dose of chloroform at 200 mg/kg. Blood, liver and kidney samples were obtained at 24 h after the treatment. Renal toxicity was assessed by measuring BUN and creatinine levels, and by pathological examination. The blood and tissue levels of chloroform were determined. The severity of toxicity was less in PTCN and CL mice, compared with that of WT and XPT-CL mice. There were no significant differences in chloroform levels in the blood, liver, or kidney, between PTCN and WT mice, or between XPT-CL and CL mice. These findings indicate that local P450-dependent activities play an important role in the nephrotoxicity induced by chloroform. Our results also demonstrate the usefulness of these novel mouse models for studies of chemical-induced kidney toxicity. - Highlights: New mouse models were developed with varying P450 activities in the proximal tubule. These mouse models were treated with chloroform, a nephrotoxicant. Studies showed the importance of local P450s in chloroform-induced nephrotoxicity.

Liu, Senyan [Kidney Institute and Division of Nephrology, Changzheng Hospital, Shanghai 200003 (China); Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York, Albany, NY 12201 (United States); Yao, Yunyi; Lu, Shijun; Aldous, Kenneth; Ding, Xinxin [Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York, Albany, NY 12201 (United States); Mei, Changlin, E-mail: chlmei1954@126.com [Kidney Institute and Division of Nephrology, Changzheng Hospital, Shanghai 200003 (China); Gu, Jun, E-mail: jungu@wadsworth.org [Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York, Albany, NY 12201 (United States)

2013-10-01T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
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they are not comprehensive nor are they the most current set.
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to obtain the most current and comprehensive results.


301

Barbara McClintock, Jumping Genes, and Transposition  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Barbara McClintock and Transposable Genetic Elements McClintock Honored · Woman of Science · Educational Material · Resources with Additional Information Barbara McClintock's remarkable life spanned the history of genetics in the twentieth century. ... [T]he science of genetics, to which McClintock made seminal contributions both experimental and conceptual, has come to dominate all of the biological sciences, from molecular biology, through cell and developmental biology, to medicine and agriculture. ... Barbara McClintock Courtesy of the Cold Spring Harbor Laboratory Archives McClintock made her first significant contribution as a graduate student, developing cytological techniques that allowed her to identify each of the ten maize chromosomes. These early experiments laid the groundwork for a remarkable series of cytogenetic discoveries ... [for which] McClintock was the intellectual driving force ... . These include identification of maize linkage groups with individual chromosomes, the well-known cytological proof of genetic crossing-over, evidence of chromatid crossing-over, cytological determination of the physical location of genes within chromosomes, identification of the genetic consequences of nonhomologous pairing, establishment of the causal relationship between the instability of ring-shaped chromosomes and phenotypic variegation, discovery that the centromere is divisible, and identification of a chromosomal site essential for the formation of the nucleolus. ...

302

The circular jump is a white hole G. Jannes,1  

E-Print Network [OSTI]

on the surface of the fluid (c = gh in the shallow-water gravity wave limit, with h the fluid height and g is such that vs r > c so that surface ripples can only propagate downstream--to a subcritical flow outside, where and subcritical typically refer to the value of the Froude number Fr = vs r/ gh or the related Mach num- ber M

Weeks, Eric R.

303

NUMERICAL SIMULATIONS OF KATABATIC JUMPS IN COATS LAND, ANTARCTICA  

E-Print Network [OSTI]

supercritical to subcritical flow, in a hydraulic sense, i.e., the Froude number (Fr) of the flow changes from-Layer Meteorology (2005) 114: 413­437 ? Springer 2005 #12;taining coastal open water areas (polynyas) (Bromwich, this corresponds to a change from supercritical (Froude number Fr > 1) to subcritical (Fr

Renfrew, Ian

304

Hanford's Recovery Act Payments Jump Past $1 Billion | Department...  

Office of Environmental Management (EM)

Richland Operations Office's (RL) American Recovery and Reinvestment Act payments at Hanford recently surpassed 1 billion. RL was allocated 1.63 billion from the Recovery Act...

305

Optimal Execution Under Jump Models For Uncertain Price Impact  

E-Print Network [OSTI]

Aug 13, 2012 ... A major source of the execution cost comes from price impacts of both the investor's own trades and other concurrent institutional trades.

Somayeh Moazeni

2012-08-13T23:59:59.000Z

306

Range Image Segmentation by an Effective Jump-Diffusion Method  

E-Print Network [OSTI]

associated reflectance image in the Bayesian framework. The algorithm works on complex real-world scenes parameter setting. The results are satisfactory in comparison with manual segmentations. Keywords Energy, Hough Transform, Change Point Detection. Departments of Computer Science and Statistics, University

Zhu, Song Chun

307

Range Image Segmentation by an Effective Jump-Diffusion Method  

E-Print Network [OSTI]

and its associated reflectance image in the Bayesian framework. The algorithm works on complex real-world parameter setting. The results are satisfactory in comparison with manual segmentations. Index Terms--Energy accessible to many users. These scanners can capture accurate 3D range images of real-world scenes at large

Zhu, Song Chun

308

Jump, scrape, break the switches Coast low wit da bitches  

E-Print Network [OSTI]

Psylocibin, peyote Mda and dnt spells ecstasy Güero canelo Coil spring, bounce, crank Pumps, shocks Mda and dnt spells ecstasy Güero canelo Coil spring, bounce, crank Pumps, shocks, struts, tanks

Reiners, Peter W.

309

A jump persistent turning walker to model zebrafish locomotion  

Science Journals Connector (OSTI)

...particle kinematics in statistical physics [37-39], and the dispersal...1992 Stochastic processes in physics and chemistry. Amsterdam...0540 ) 58 Gardiner, C . 1985 Handbook of stochastic methods: for physics, chemistry, and the natural...

2015-01-01T23:59:59.000Z

310

Sharp Jump in Teaching Fellows Draws Fire From Educators  

Science Journals Connector (OSTI)

...them in the schools? asks Michael Lubell of the American Physical Society. Gerald Wheeler...schools and see what happens? asks Lubell. But Colwell...sticking them in the schools? asks Michael Lubell of the American Physical Society...

Jeffrey Mervis

2000-04-21T23:59:59.000Z

311

jump to: current year previous years collapse all expand all  

E-Print Network [OSTI]

dynamical systems, such as predicting the weather or planning the trajectory of a satellite. However a theoretical explanation for the success of algorithms that organize patches according to graph-based metrics

Torquato, Salvatore

312

Hanford's Recovery Act Payments Jump Past $1 Billion  

Broader source: Energy.gov (indexed) [DOE]

WASH. - The Richland Operations Office's WASH. - The Richland Operations Office's (RL) American Recovery and Reinvestment Act payments at Hanford recently surpassed $1 billion. RL was allocated $1.63 billion from the Recovery Act in 2009 in order to create jobs and reduce the footprint of active cleanup at Hanford. In key Recovery Act accomplishments, RL: * Reduced Hanford's cleanup footprint by a total of 143 square miles by re- moving more than 20 facilities and hundreds of debris sites on the Hanford Reach National Monument, a 300-square mile area around Hanford formerly used for military activity and research. * Demolished 56 facilities, which reduces surveillance and maintenance costs. * Completed expansion of Hanford's Environmental Restoration Disposal Facil- ity (ERDF) ahead of schedule and under budget, increasing its capacity to

313

Patterns in fish assemblages and seagrass herbivory in a temperate Australian seagrass meadow.  

E-Print Network [OSTI]

??While eutrophication of coastal waters has long been attributed as a major cause of seagrass decline, there is now emerging evidence from both tropical and (more)

White, Kirrily

2011-01-01T23:59:59.000Z

314

Coupled hydrological and biogeochemical dynamics in high elevation meadows: thresholds, resiliency and change  

E-Print Network [OSTI]

Education, in press Exceedance of historic limit of dryness triggers hydrological tipping point in high elevation peatlands In preparation CONFERENCE POSTER

Arnold, Chelsea Lynn

2014-01-01T23:59:59.000Z

315

Feeding behaviour of wethers fed ad libitum or limited-fed with hay of natural meadows  

E-Print Network [OSTI]

fine wool breed, were consecu-tively fed ad libitum (10 % refusals) FAL, and limited-fed (60 at the end of every 8-day experimental period to determine forage digestibility. The feeding parameters were to commonly observed lower digestibility of forages fed ad libitum. There was no significant difference

Paris-Sud XI, Université de

316

Impact of cutting date on carabids and spiders in a wet meadow Denis Lafagea,b,*  

E-Print Network [OSTI]

.g. Britschgi et al., 2006) and phytophagous arthropods (e.g. Morris and Plant, 1983) has been well studied-Benítez and Méndez, 2011) or leafhoppers (Rothenbücher and Schaefer, 2006) in particular. Arthropods are however in pest control (Symondson et al., 2002). Spiders are sensitive to changes in habitat structure (Duffey

Paris-Sud XI, Université de

317

Truckee Meadows Community College and Colorado School of Mines Win Geothermal Student Competitions  

Broader source: Energy.gov [DOE]

The Energy Department announced the 2014 winners of the National Geothermal Student Competition and the Geothermal Case Study Challenge last week at an industry gathering in Portland, Oregon. These...

318

Impaired Organization and Function of Myofilaments in Single Muscle Fibers from a Mouse Model of Pompe Disease  

SciTech Connect (OSTI)

Pompe disease, a deficiency of lysosomal acid {alpha}-glucosidase, is a disorder of glycogen metabolism that can affect infants, children, or adults. In all forms of the disease, there is progressive muscle pathology leading to premature death. The pathology is characterized by accumulation of glycogen in lysosomes, autophagic buildup, and muscle atrophy. The purpose of the present investigation was to determine if myofibrillar dysfunction in Pompe disease contributes to muscle weakness beyond that attributed to atrophy. The study was performed on isolated myofibers dissected from severely affected fast glycolytic muscle in the {alpha}-glucosidase knockout mouse model. Psoas muscle fibers were first permeabilized, so that the contractile proteins could be directly relaxed or activated by control of the composition of the bathing solution. When normalized by cross-sectional area, single fibers from knockout mice produced 6.3 N/cm{sup 2} of maximum Ca{sup 2+}-activated tension compared with 12.0 N/cm{sup 2} produced by wild-type fibers. The total protein concentration was slightly higher in the knockout mice, but concentrations of the contractile proteins myosin and actin remained unchanged. Structurally, X-ray diffraction showed that the actin and myosin filaments, normally arranged in hexagonal arrays, were disordered in the knockout muscle, and a lower fraction of myosin cross bridges was near the actin filaments in the relaxed muscle. The results are consistent with a disruption of actin and myosin interactions in the knockout muscles, demonstrating that impaired myofibrillar function contributes to weakness in the diseased muscle fibers.

Xu, S.; Galperin, M; Melvin, G; Horowits, R; Raben, N; Plotz, P; Yu, L

2010-01-01T23:59:59.000Z

319

Characterization of the multigene family encoding the mouse S16 ribosomal protein: strategy for distinguishing an expressed gene from its processed pseudogene counterparts by an analysis of total genomic DNA.  

Science Journals Connector (OSTI)

...status of each gene; (ii) thermal stability of genomic DNA-cDNA...we digested mouse DNA with a battery of enzymes and subjected the...pseudogene, respectively. Thermal stability of S16 cDNA-S16...Based on this reasoning, a thermal stability experiment was performed...

M Wagner; R P Perry

1985-12-01T23:59:59.000Z

320

Exploring the in vitro formation of trimethylarsine sulfide from dimethylthioarsinic acid in anaerobic microflora of mouse cecum using HPLC-ICP-MS and HPLC-ESI-MS  

SciTech Connect (OSTI)

Although metabolism of arsenicals to form methylated oxoarsenical species has been extensively studied, less is known about the formation of thiolated arsenical species that have recently been detected as urinary metabolites. Indeed, their presence suggests that the metabolism of ingested arsenic is more complex than previously thought. Recent reports have shown that thiolated arsenicals can be produced by the anaerobic microflora of the mouse cecum, suggesting that metabolism prior to systemic absorption may be a significant determinant of the pattern and extent of exposure to various arsenic-containing species. Here, we examined the metabolism of {sup 34}S labeled dimethylthioarsinic acid ({sup 34}S-DMTA{sup V}) by the anaerobic microflora of the mouse cecum using HPLC-ICP-MS and HPLC-ESI-MS/MS to monitor for the presence of various oxo- and thioarsenicals. The use of isotopically enriched {sup 34}S-DMTA{sup V} made it possible to differentiate among potential metabolic pathways for production of the trimethylarsine sulfide (TMAS{sup V}). Upon in vitro incubation in an assay containing anaerobic microflora of mouse cecum, {sup 34}S-DMTA{sup V} underwent several transformations. Labile {sup 34}S was exchanged with more abundant {sup 32}S to produce {sup 32}S-DMTA{sup V}, a thiol group was added to yield DMDTA{sup V}, and a methyl group was added to yield {sup 34}S-TMAS{sup V}. Because incubation of {sup 34}S-DMTA{sup V} resulted in the formation of {sup 34}S-TMAS{sup V}, the pathway for its formation must preserve the arsenic-sulfur bond. The alternative metabolic pathway postulated for formation of TMAS{sup V} from dimethylarsinic acid (DMA{sup V}) would proceed via a dimethylarsinous acid (DMA{sup III}) intermediate and would necessitate the loss of {sup 34}S label. Structural confirmation of the metabolic product was achieved using HPLC-ESI-MS/MS. The data presented support the direct methylation of DMTA{sup V} to TMAS{sup V}. Additionally, the detection of isotopically pure {sup 34}S-TMAS{sup V} raises questions about the sulfur exchange properties of TMAS{sup V} in the cecum material. Therefore, {sup 34}S-TMAS{sup V} was incubated and the exchange was monitored with respect to time. The data suggest that the As-S bond associated with TMAS{sup V} is less labile than the As-S bond associated with DMTA{sup V}.

Kubachka, Kevin M. [US EPA, ORD, NERL, Microbiological and Chemical Exposure, Assessment Research Division, Cincinnati, OH 45268 (United States); Kohan, Michael C. [US EPA, ORD, NHEERL, Environmental Carcinogenesis Division, Research Triangle Park, NC 27711 (United States); Herbin-Davis, Karen [US EPA, ORD, NHEERL, Experimental Toxicology Division, Research Triangle Park, NC 27711 (United States); Creed, John T. [US EPA, ORD, NERL, Microbiological and Chemical Exposure, Assessment Research Division, Cincinnati, OH 45268 (United States)], E-mail: creed.jack@epa.gov; Thomas, David J. [US EPA, ORD, NHEERL, Experimental Toxicology Division, Research Triangle Park, NC 27711 (United States)

2009-09-01T23:59:59.000Z

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321

Parg deficiency confers radio-sensitization through enhanced cell death in mouse ES cells exposed to various forms of ionizing radiation  

SciTech Connect (OSTI)

Highlights: Parg{sup ?/?} ES cells were more sensitive to ?-irradiation than Parp-1{sup ?/?} ES cells. Parg{sup ?/?} cells were more sensitive to carbon-ion irradiation than Parp-1{sup ?/?} cells. Parg{sup ?/?} cells showed defects in DSB repair after carbon-ion irradiation. PAR accumulation was enhanced after carbon-ion irradiation compared to ?-irradiation. -- Abstract: Poly(ADP-ribose) glycohydrolase (Parg) is the main enzyme involved in poly(ADP-ribose) degradation. Here, the effects of Parg deficiency on sensitivity to low and high linear-energy-transfer (LET) radiation were investigated in mouse embryonic stem (ES) cells. Mouse Parg{sup ?/?} and poly(ADP-ribose) polymerase-1 deficient (Parp-1{sup ?/?}) ES cells were used and responses to low and high LET radiation were assessed by clonogenic survival and biochemical and biological analysis methods. Parg{sup ?/?} cells were more sensitive to ?-irradiation than Parp-1{sup ?/?} cells. Transient accumulation of poly(ADP-ribose) was enhanced in Parg{sup ?/?} cells. Augmented levels of phosphorylated H2AX (?-H2AX) from early phase were observed in Parg{sup ?/?} ES cells. The induction level of p53 phophorylation at ser18 was similar in wild-type and Parp-1{sup ?/?} cells and apoptotic cell death process was mainly observed in the both genotypes. These results suggested that the enhanced sensitivity of Parg{sup ?/?} ES cells to ?-irradiation involved defective repair of DNA double strand breaks. The effects of Parg and Parp-1 deficiency on the ES cell response to carbon-ion irradiation (LET13 and 70 keV/?m) and Fe-ion irradiation (200 keV/?m) were also examined. Parg{sup ?/?} cells were more sensitive to LET 70 keV/?m carbon-ion irradiation than Parp-1{sup ?/?} cells. Enhanced apoptotic cell death also accompanied augmented levels of ?-H2AX in a biphasic manner peaked at 1 and 24 h. The induction level of p53 phophorylation at ser18 was not different between wild-type and Parg{sup ?/?} cells. The augmented level of poly(ADP-ribose) accumulation was noted after carbon-ion irradiation compared to ?-irradiation even in the wild-type cells. An enhanced poly(ADP-ribose) accumulation was further observed in Parg{sup ?/?} cells. Both Parg{sup ?/?} cells and Parp-1{sup ?/?} cells did not show sensitization to Fe-ion irradiation. Parg deficiency sensitizes mouse ES cells to a wide therapeutic range of LET radiation through the effects on DNA double strand break repair responses and enhanced cell death.

Shirai, Hidenori; Fujimori, Hiroaki [Division of Genome Stability Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan)] [Division of Genome Stability Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan); Gunji, Akemi [Biochemistry Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan)] [Biochemistry Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan); Maeda, Daisuke [Biochemistry Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan) [Biochemistry Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan); ADP-Ribosylation in Oncology Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan); Hirai, Takahisa [Division of Genome Stability Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan) [Division of Genome Stability Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan); Department of Radiation Oncology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Poetsch, Anna R. [ADP-Ribosylation in Oncology Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan)] [ADP-Ribosylation in Oncology Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan); Harada, Hiromi [Division of Genome Stability Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan)] [Division of Genome Stability Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan); Yoshida, Tomoko [Biochemistry Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan) [Biochemistry Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan); Kyoritsu College of Pharmacy, 1-5-30 Shibakoen, Minatoku, Tokyo 105-8512 (Japan); Sasai, Keisuke [Department of Radiation Oncology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan)] [Department of Radiation Oncology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Okayasu, Ryuichi [International Open Laboratory, National Institute of Radiological Science, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan)] [International Open Laboratory, National Institute of Radiological Science, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan); Masutani, Mitsuko, E-mail: mmasutan@ncc.go.jp [Division of Genome Stability Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan) [Division of Genome Stability Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan); Biochemistry Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan); ADP-Ribosylation in Oncology Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045 (Japan)

2013-05-24T23:59:59.000Z

322

Attenuation of Mouse Melanoma by A/C Magnetic Field after Delivery of Bi-Magnetic Nanoparticles by Neural Progenitor Cells  

Science Journals Connector (OSTI)

Attenuation of Mouse Melanoma by A/C Magnetic Field after Delivery of Bi-Magnetic Nanoparticles by Neural Progenitor Cells ... 0.5% w/w) and clinically acceptable magnetic fields, intratumoral power absorption is comparable to RF heating with local applicators and superior to regional RF heating (by comparison with clinical SAR measurements from regional and local hyperthermia treatments). ... With the exception of the K562 cell line, all 9 leukemic cell lines tested were resistant to the natural killer activity of freshly isolated peripheral blood lymphocytes (PBL) from healthy donors but were susceptible to the lytic action of PBL cultured for 3 days in the presence of rIL-2. ...

Raja Shekar Rachakatla; Sivasai Balivada; Gwi-Moon Seo; Carl B. Myers; Hongwang Wang; Thilani N. Samarakoon; Raj Dani; Marla Pyle; Franklin O. Kroh; Brandon Walker; Xiaoxuan Leaym; Olga B. Koper; Viktor Chikan; Stefan H. Bossmann; Masaaki Tamura; Deryl L. Troyer

2010-11-08T23:59:59.000Z

323

Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: Potential model for thymic education  

SciTech Connect (OSTI)

Characteristic lesions in mice hemi- or homozygous for the X-linked mutation scurfy (sf) include lymphohistiocytic proliferation in the skin and lymphoid organs, Coombs' test-positive anemia, hypergammaglobulinemia, and death by 24 days of age. The role of the thymus in the development of fatal lymphoreticular disease in the scurfy mouse was investigated. Neonatal thymectomy doubles the life span of scurfy mice, moderates the histologic lesions, and prevents anemia, despite the continued presence of high levels of serum IgG. Animals bred to be nude and scurfy (nu/nu;sf/Y) are viable, fertile, and free of scurfy lesions. Bone marrow from scurfy mice can reconstitute lethally irradiated, H-2-compatible animals but does not transmit scurfy disease. The authors conclude, from these data, that scurfy lesions are mediated by T lymphocytes that mature in an abnormal (sf) thymic environment.

Godfrey, V.L.; Rinchik, E.M.; Russell, L.B. (Oak Ridge National Lab., Oak Ridge, TN (United States)); Wilkinson, J.E. (Univ. of Tennessee, Knoxville (United States))

1991-07-01T23:59:59.000Z

324

DOI-BLM-NV-C010-2012-0057-CX | Open Energy Information  

Open Energy Info (EERE)

CX CX Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home NEPA Document Collection for: DOI-BLM-NV-C010-2012-0057-CX CX at Dixie Meadows Geothermal Area for Geothermal/Exploration {{{NEPA_Name}}} General NEPA Document Info Energy Sector Geothermal energy Environmental Analysis Type CX Applicant Ormat Technologies Inc Geothermal Area Dixie Meadows Geothermal Area Project Location Nevada Project Phase Geothermal/Exploration Techniques Thermal Gradient Holes Time Frame (days) Application Time 25 Participating Agencies Lead Agency BLM Funding Agency none provided Managing District Office Carson City Managing Field Office Stillwater Funding Agencies none provided Surface Manager BLM Mineral Manager BLM Selected Dates Application Date 5/24/2012 Decision Document Date 6/18/2012

325

DOI-BLM-NV-C010-2012-0058-DNA | Open Energy Information  

Open Energy Info (EERE)

form form View source History View New Pages Recent Changes All Special Pages Semantic Search/Querying Get Involved Help Apps Datasets Community Login | Sign Up Search Page Edit with form History Facebook icon Twitter icon » DOI-BLM-NV-C010-2012-0058-DNA Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home NEPA Document Collection for: DOI-BLM-NV-C010-2012-0058-DNA DNA at Dixie Meadows Geothermal Area for Geothermal/Well Field {{{NEPA_Name}}} General NEPA Document Info Energy Sector Geothermal energy Environmental Analysis Type DNA Applicant Ormat Technologies Inc Geothermal Area Dixie Meadows Geothermal Area Project Location Nevada Project Phase Geothermal/Well Field Techniques Observation Wells Time Frame (days) Participating Agencies Lead Agency BLM Funding Agency none provided

326

DOI-BLM-NV-CO1000-2010-0009-CX | Open Energy Information  

Open Energy Info (EERE)

10-0009-CX 10-0009-CX Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home NEPA Document Collection for: DOI-BLM-NV-CO1000-2010-0009-CX CX at Dixie Meadows Geothermal Area for Geothermal/Exploration {{{NEPA_Name}}} General NEPA Document Info Energy Sector Geothermal energy Environmental Analysis Type CX Applicant Terra-Gen Power LLC Geothermal Area Dixie Meadows Geothermal Area Project Location Nevada Project Phase Geothermal/Exploration Techniques Electromagnetic Techniques Time Frame (days) Application Time 209 Participating Agencies Lead Agency BLM Funding Agency none provided Managing District Office Carson City Managing Field Office Stillwater Funding Agencies none provided Surface Manager BLM Mineral Manager BLM Selected Dates Application Date 6/30/2009

327

DOI-BLM-NV-C010-2013-0022-DNA | Open Energy Information  

Open Energy Info (EERE)

22-DNA 22-DNA Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home NEPA Document Collection for: DOI-BLM-NV-C010-2013-0022-DNA DNA at Dixie Meadows Geothermal Area for Geothermal/Exploration {{{NEPA_Name}}} General NEPA Document Info Energy Sector Geothermal energy Environmental Analysis Type DNA Applicant Ormat Technologies Inc Geothermal Area Dixie Meadows Geothermal Area Project Location Nevada Project Phase Geothermal/Exploration Techniques Thermal Gradient Holes Comments Core hole/TGH Time Frame (days) Participating Agencies Lead Agency BLM Funding Agency none provided Managing District Office Carson City Managing Field Office Stillwater Funding Agencies none provided Surface Manager BLM Mineral Manager BLM Selected Dates Application Document Type NOI

328

Geobotanical Remote Sensing Applied To Targeting New Geothermal Resource  

Open Energy Info (EERE)

Geobotanical Remote Sensing Applied To Targeting New Geothermal Resource Geobotanical Remote Sensing Applied To Targeting New Geothermal Resource Locations In The Us Basin And Range With A Focus On Dixie Meadows, Nv Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Journal Article: Geobotanical Remote Sensing Applied To Targeting New Geothermal Resource Locations In The Us Basin And Range With A Focus On Dixie Meadows, Nv Details Activities (1) Areas (1) Regions (0) Abstract: This paper presents an overview of the work our collaboration is doing to increase the detailed mapped resource base for geothermal exploration in the Western US. We are imaging several large areas in the western US with high resolution airborne hyperspectral and satellite multispectral sensors. We have now entered the phase where the remote sensing techniques and tools we are developing are mature enough to be

329

Using ex vivo organ culture models as surrogates to investigate morphological and functional differences of mammary glands derived from mouse strains that differ in cancer susceptibility to understand the underlying mechanisms of radiation sensitivity or resistance  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ex vivo organ culture models as surrogates to investigate morphological and functional ex vivo organ culture models as surrogates to investigate morphological and functional differences of mammary glands derived from mouse strains that differ in cancer susceptibility to understand the underlying mechanisms of radiation sensitivity or resistance Alvin Lo, Joni D. Mott, Jian-Hua Mao, and Mina J. Bissell Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley CA 94720 Goal: Within the Lawrence Berkeley National Laboratory's Low Dose SFA, as part of Project 2, we are using a systems genetics approach to determine the contribution of non-targeted and targeted radiation effects for risk of mammary carcinogenesis. The goal of this work is to characterize the mammary gland of the parental mouse strains, and the F1 and F2 generations used in these studies with respect to tissue

330

Photoaffinity Labeling of Mouse Fibroblast Enzymes by a Base Excision Repair Intermediate: New Evidence on the Role of PARP-1 in DNA Repair  

SciTech Connect (OSTI)

To examine mammalian base excision repair (BER) enzymes interacting with DNA intermediates formed during BER, we used a novel photoaffinity labeling probe and mouse embryonic fibroblast (MEF) crude extract. The probe was formed in situ, using an end-labeled oligonucleotide containing a synthetic abasic site; this site was incised by AP endonuclease creating a nick with 3' hydroxyl and 5' reduced sugar phosphate groups at the margins, and then a dNMP carrying a photoreactive adduct was introduced at the 3' hydroxyl group. With near UV-light exposure (312nm) of the extract-probe mixture, only six proteins were strongly labeled, including poly (ADP-ribose) polymerase (PARP-1) and the well-known BER participants flap endonuclease (FEN-1), DNA polymerase b (b-pol), and AP endonuclease (APE). The amount of probe crosslinked to PARP-1 was greater than that crosslinked to the other proteins. The specificity of PARP-1 labeling was examined by competition experiments involving various oligonucleotide competitors; competition of labeling by the probe was much greater for the BER intermediates tested than for normal double-stranded DNA. The specificity of PARP-1 labeling also was examined using DNA probes with alternate structures; PARP-1 labeling was stronger with a DNA oligomer representing a BER intermediate than with a molecule representing a nick in double-stranded DNA. These results identifying interaction of PARP-1 with a BER intermediate are discussed in light of PARP-1's role in mammalian BER.

Lavrik, Olga I.(National Institute of Environmental Health Sciences) [National Institute of Environmental Health Sciences; Prasad, Rajendra (National Institute of Environmental Health Sciences) [National Institute of Environmental Health Sciences; Sobol, Robert W.(National Institute of Environmental Health Sciences) [National Institute of Environmental Health Sciences; Horton, Julie K.(National Institute of Environmental Health Sciences) [National Institute of Environmental Health Sciences; Ackerman, Eric J.(BATTELLE (PACIFIC NW LAB)) [BATTELLE (PACIFIC NW LAB); Wilson, Samuel H.(National Institute of Environmental Health Sciences) [National Institute of Environmental Health Sciences

2001-07-06T23:59:59.000Z

331

Follicle-Stimulating Hormone Induction of Steel Factor (SLF) mRNA in Mouse Sertoli Cells and Stimulation of DNA Synthesis in Spermatogonia by Soluble SLF  

Science Journals Connector (OSTI)

Follicle-stimulating hormone (FSH) and its intracellular mediator, cAMP, increase the mRNA levels for the Steel factor (SLF, the c-kit ligand) in cultured primary mouse Sertoli cells. The inductive effect of cAMP is more evident in cultures from 13-day-old animals than in cultures from 18-day-old animals. Analysis through the polymerase chain reaction (PCR) indicates that (Bu)2cAMP or FSH treatment increases the levels of the mRNAs for both the potentially soluble form and the transmembrane form of SLF in cultured Sertoli cells. The ratio between mRNAs encoding the potentially soluble form and the transmembrane form of SLF increases during postnatal testis development, and it is higher in cultured Sertoli cells with respect to total testis, suggesting that, under the in vitro conditions, SLF could be produced by Sertoli cells mainly as a soluble factor. Soluble recombinant SLF stimulates, in a dose-dependent fashion, thymidine incorporation in cultures of isolated germ cell populations enriched in the mitotic stages (spermatogonia), independently of the presence of serum, whereas cAMP analogs have no effect. Autoradiographic analysis shows that SLF selectively stimulates DNA synthesis in type A spermatogonia.

Pellegrino Rossi; Susanna Dolci; Cristina Albanesi; Paola Grimaldi; Rossana Ricca; Raffaele Geremia

1993-01-01T23:59:59.000Z

332

Process-level controls on CO2 fluxes from a seasonally snow-covered subalpine meadow soil, Niwot Ridge, Colorado  

E-Print Network [OSTI]

Research, University of Colorado, Boulder, CO, USA e-mail:of Geography, University of Colorado, Boulder, CO, USA B.Sciences, University of Colorado, Boulder, CO, USA G.

2009-01-01T23:59:59.000Z

333

Native Tallgrass Prairie Remnants as "Living Museums": Landscape Context, Metacommunity Dynamics, and Private Management Practices of Native Prairie Hay Meadows  

E-Print Network [OSTI]

In fragmented tallgrass prairie remnants within eastern Kansas, smaller patch area, greater isolation, and poorer matrix quality are predicted to result in (1) decreased species richness, (2) decreased site `quality,' and ...

Kilroy Mollmann, Hayley A.

2010-08-27T23:59:59.000Z

334

Vegetation dynamics of a native haymeadow, a grazed meadow, and an oldfield within the San Antonio Prairie of Texas  

E-Print Network [OSTI]

) and Bifora americana (b) foliar cover acrss 6 sample dates for the non- d f 11 t d aad d f Ifatad a~ps Iithiti Idfi Id, gra d d d h y d iti based on DECORAHA analysis. Open circles represent position of the coavaunity within the ordination. 250 200 44... 'Pl UPlo usia[ Id p ~!I 4 P P P n!I ~ P -uou aq'j Jog sagep a[deus g ssoJoe wahoo Jei(og (q) eSeuioun eLqueJqog pue (e) enJeee enIua[aH 6 aan6ig 250 200 44 x 150 100 50- IDIDIDLD ~ / / / ~ . DDIND IDDDDI ) / / / / I I...

Hightower, Terry Paul

2012-06-07T23:59:59.000Z

335

New Colchicinoids from a Native Jordanian Meadow Saffron, Colchicum brachyphyllum: Isolation of the First Naturally Occurring Dextrorotatory  

E-Print Network [OSTI]

of their toxic nature, and in Arabian writings of the tenth century, they were recommended for use in gout

Falkinham, Joseph

336

Effects of the PPAR{gamma} agonist troglitazone on endothelial cells in vivo and in vitro: Differences between human and mouse  

SciTech Connect (OSTI)

Peroxisome proliferator-activated receptor gamma (PPAR{gamma}) agonists and PPAR{gamma}/{alpha} dual agonists have been or are being developed for clinical use in the treatment of type 2 diabetes mellitus and hyperlipidemias. A common tumor finding in rodent carcinogenicity studies for these agonists is hemangioma/hemangiosarcoma in mice but not in rats. We hypothesized that increased endothelial cell proliferation may be involved in the mechanism of PPAR agonist-induced vascular tumors in mice, and we investigated the effects on endothelial cells utilizing troglitazone, the first clinically used PPAR{gamma} agonist, in vivo and in vitro. Troglitazone (400 and 800 mg/kg/day) induced hemangiosarcomas in mice in a 2-year bioassay. We showed that troglitazone increased endothelial cell proliferation in brown and white adipose tissue and liver in mice at sarcomagenic doses after 4 weeks of treatment. Troglitazone was cytotoxic both to human dermal microvascular endothelial cells (HMEC1) and mouse mammary fat pad microvascular endothelial cells (MFP MVEC) at high concentrations. However, MFP MVEC were more resistant to the cytotoxic effects of troglitazone based on the much lower LC{sub 50} in HMEC1 (17.4 {mu}M) compared to MFP MVEC (92.2 {mu}M). Troglitazone increased the proliferation and survival of MFP MVEC but not HMEC1 in growth factor reduced conditions. Our data demonstrate that troglitazone may induce hemangiosarcomas in mice, at least in part, through enhancement of survival and proliferation of microvascular endothelial cells. Such an effect does not occur with human cells, suggesting that human may react differently to exposure to PPAR agonists compared with mice.

Kakiuchi-Kiyota, Satoko [Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135 (United States); Vetro, Joseph A. [Center for Drug Delivery and Nanomedicine and Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198-6025 (United States); Suzuki, Shugo; Varney, Michelle L. [Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135 (United States); Han, Huai-Yun [Center for Drug Delivery and Nanomedicine and Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198-6025 (United States); Nascimento, Merielen; Pennington, Karen L.; Arnold, Lora L.; Singh, Rakesh K. [Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135 (United States); Cohen, Samuel M. [Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135 (United States)], E-mail: scohen@unmc.edu

2009-05-15T23:59:59.000Z

337

Extracellular ATP-induced nuclear Ca{sup 2+} transient is mediated by inositol 1,4,5-trisphosphate receptors in mouse pancreatic {beta}-cells  

SciTech Connect (OSTI)

Extracellular ATP (eATP) induces an intracellular Ca{sup 2+} transient by activating phospholipase C (PLC)-associated P2X4 purinergic receptors, leading to production of inositol 1,4,5-trisphosphate (IP3) and subsequent Ca{sup 2+} release from intracellular stores in mouse pancreatic {beta}-cells. Using laser scanning confocal microscopy, Ca{sup 2+} indicator fluo-4 AM, and the cell permeable nuclear indicator Hoechst 33342, we examined the properties of eATP-induced Ca{sup 2+} release in pancreatic {beta}-cell nuclei. eATP induced a higher nuclear Ca{sup 2+} transient in pancreatic {beta}-cell nuclei than in the cytosol. After pretreatment with thapsigargin (TG), an inhibitor of sarco-endoplasmic reticulum Ca{sup 2+}-ATPase (SERCA) pumps, the amplitude of eATP-induced Ca{sup 2+} transients in the nucleus was still much higher than those in the cytosol. This effect of eATP was not altered by inhibition of either the plasma membrane Ca{sup 2+}-ATPase (PMCA) or the plasma membrane Na{sup +}/Ca{sup 2+} exchanger (NCX) by LaCl{sub 3} or by replacement of Na{sup +} with N-Methyl-Glucosamine. eATP-induced nuclear Ca{sup 2+} transients were abolished by a cell-permeable IP3R inhibitor, 2-aminoethoxydiphenyl borate (2-APB), but were not blocked by the ryanodine receptor (RyR) antagonist ryanodine. Immunofluorescence studies showed that IP3Rs are expressed on the nuclear envelope of pancreatic {beta}-cells. These results indicate that eATP triggers nuclear Ca{sup 2+} transients by mobilizing a nuclear Ca{sup 2+} store via nuclear IP3Rs.

Chen, Zheng; Li, Zhengzheng; Peng, Gong; Chen, Xiaoli; Yin, Wenxuan [National Laboratory of Biomacromolecules, Institute of Biophysics of Chinese Academy of Sciences, 15 Datun Rd., Beijing 100101 (China)] [National Laboratory of Biomacromolecules, Institute of Biophysics of Chinese Academy of Sciences, 15 Datun Rd., Beijing 100101 (China); Kotlikoff, Michael I. [Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 (United States)] [Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 (United States); Yuan, Zeng-qiang, E-mail: zqyuan@sun5.ibp.ac.cn [National Laboratory of Biomacromolecules, Institute of Biophysics of Chinese Academy of Sciences, 15 Datun Rd., Beijing 100101 (China)] [National Laboratory of Biomacromolecules, Institute of Biophysics of Chinese Academy of Sciences, 15 Datun Rd., Beijing 100101 (China); Ji, Guangju, E-mail: gj28@ibp.ac.cn [National Laboratory of Biomacromolecules, Institute of Biophysics of Chinese Academy of Sciences, 15 Datun Rd., Beijing 100101 (China)] [National Laboratory of Biomacromolecules, Institute of Biophysics of Chinese Academy of Sciences, 15 Datun Rd., Beijing 100101 (China)

2009-05-01T23:59:59.000Z

338

CHIR99021 promotes self-renewal of mouse embryonic stem cells by modulation of protein-encoding gene and long intergenic non-coding RNA expression  

SciTech Connect (OSTI)

Embryonic stem cells (ESCs) can proliferate indefinitely in vitro and differentiate into cells of all three germ layers. These unique properties make them exceptionally valuable for drug discovery and regenerative medicine. However, the practical application of ESCs is limited because it is difficult to derive and culture ESCs. It has been demonstrated that CHIR99021 (CHIR) promotes self-renewal and enhances the derivation efficiency of mouse (m)ESCs. However, the downstream targets of CHIR are not fully understood. In this study, we identified CHIR-regulated genes in mESCs using microarray analysis. Our microarray data demonstrated that CHIR not only influenced the Wnt/?-catenin pathway by stabilizing ?-catenin, but also modulated several other pluripotency-related signaling pathways such as TGF-?, Notch and MAPK signaling pathways. More detailed analysis demonstrated that CHIR inhibited Nodal signaling, while activating bone morphogenetic protein signaling in mESCs. In addition, we found that pluripotency-maintaining transcription factors were up-regulated by CHIR, while several developmental-related genes were down-regulated. Furthermore, we found that CHIR altered the expression of epigenetic regulatory genes and long intergenic non-coding RNAs. Quantitative real-time PCR results were consistent with microarray data, suggesting that CHIR alters the expression pattern of protein-encoding genes (especially transcription factors), epigenetic regulatory genes and non-coding RNAs to establish a relatively stable pluripotency-maintaining network. - Highlights: Combined use of CHIR with LIF promotes self-renewal of J1 mESCs. CHIR-regulated genes are involved in multiple pathways. CHIR inhibits Nodal signaling and promotes Bmp4 expression to activate BMP signaling. Expression of epigenetic regulatory genes and lincRNAs is altered by CHIR.

Wu, Yongyan [College of Veterinary Medicine, Northwest A and F University, Yangling 712100, Shaanxi (China); Key Laboratory of Animal Biotechnology, Ministry of Agriculture, Northwest A and F University, Yangling 712100, Shaanxi (China); Ai, Zhiying [Key Laboratory of Animal Biotechnology, Ministry of Agriculture, Northwest A and F University, Yangling 712100, Shaanxi (China); College of Life Sciences, Northwest A and F University, Yangling 712100, Shaanxi (China); Yao, Kezhen [College of Veterinary Medicine, Northwest A and F University, Yangling 712100, Shaanxi (China); Key Laboratory of Animal Biotechnology, Ministry of Agriculture, Northwest A and F University, Yangling 712100, Shaanxi (China); Cao, Lixia; Du, Juan; Shi, Xiaoyan [Key Laboratory of Animal Biotechnology, Ministry of Agriculture, Northwest A and F University, Yangling 712100, Shaanxi (China); College of Life Sciences, Northwest A and F University, Yangling 712100, Shaanxi (China); Guo, Zekun, E-mail: gzk@nwsuaf.edu.cn [College of Veterinary Medicine, Northwest A and F University, Yangling 712100, Shaanxi (China); Key Laboratory of Animal Biotechnology, Ministry of Agriculture, Northwest A and F University, Yangling 712100, Shaanxi (China); Zhang, Yong, E-mail: zhylab@hotmail.com [College of Veterinary Medicine, Northwest A and F University, Yangling 712100, Shaanxi (China); Key Laboratory of Animal Biotechnology, Ministry of Agriculture, Northwest A and F University, Yangling 712100, Shaanxi (China)

2013-10-15T23:59:59.000Z

339

The diabetogenic mouse MHC class II molecule I-A[subscript g7] is endowed with a switch that modulates TCR affinity  

SciTech Connect (OSTI)

Genetic susceptibility to autoimmunity is frequently associated with specific MHC alleles. Diabetogenic MHC class II molecules, such as human HLA-DQ8 and mouse I-A{sub g7}, typically have a small, uncharged amino acid residue at position 57 of their {beta} chain ({beta}57); this results in the absence of a salt bridge between {beta}57 and Arg{alpha}76, which is adjacent to the P9 pocket of the peptide-binding groove. However, the influence of Arg{alpha}76 on the selection of the TCR repertoire remains unknown, particularly when the MHC molecule binds a peptide with a neutral amino acid residue at position P9. Here, we have shown that diabetogenic MHC class II molecules bound to a peptide with a neutral P9 residue primarily selected and expanded cells expressing TCRs bearing a negatively charged residue in the first segment of their complementarity determining region 3{beta}. The crystal structure of one such TCR in complex with I-A{sub g7} bound to a peptide containing a neutral P9 residue revealed that a network of favorable long-range (greater than 4 {angstrom}) electrostatic interactions existed among Arg{alpha}76, the neutral P9 residue, and TCR, which supported the substantially increased TCR/peptide-MHC affinity. This network could be modulated or switched to a lower affinity interaction by the introduction of a negative charge at position P9 of the peptide. Our results support the existence of a switch at residue {beta}57 of the I-Ag7 and HLA-DQ8 class II molecules and potentially link normal thymic TCR selection with abnormal peripheral behavior.

Yoshida, Kenji; Corper, Adam L.; Herro, Rana; Jabri, Bana; Wilson, Ian A.; Teyton, Luc (Scripps); (UC)

2011-11-16T23:59:59.000Z

340

The diabetogenic mouse MHC class II molecule I-A[superscript g7] is endowed with a switch that modulates TCR affinity  

SciTech Connect (OSTI)

Genetic susceptibility to autoimmunity is frequently associated with specific MHC alleles. Diabetogenic MHC class II molecules, such as human HLA-DQ8 and mouse I-A{sup g7}, typically have a small, uncharged amino acid residue at position 57 of their {beta} chain ({beta}57); this results in the absence of a salt bridge between {beta}57 and Arg{alpha}76, which is adjacent to the P9 pocket of the peptide-binding groove. However, the influence of Arg{alpha}76 on the selection of the TCR repertoire remains unknown, particularly when the MHC molecule binds a peptide with a neutral amino acid residue at position P9. Here, we have shown that diabetogenic MHC class II molecules bound to a peptide with a neutral P9 residue primarily selected and expanded cells expressing TCRs bearing a negatively charged residue in the first segment of their complementarity determining region 3{beta}. The crystal structure of one such TCR in complex with I-Ag7 bound to a peptide containing a neutral P9 residue revealed that a network of favorable long-range (greater than 4 {angstrom}) electrostatic interactions existed among Arg{alpha}76, the neutral P9 residue, and TCR, which supported the substantially increased TCR/peptide-MHC affinity. This network could be modulated or switched to a lower affinity interaction by the introduction of a negative charge at position P9 of the peptide. Our results support the existence of a switch at residue {beta}57 of the I-A{sup g7} and HLA-DQ8 class II molecules and potentially link normal thymic TCR selection with abnormal peripheral behavior.

Yoshida, Kenji; Corper, Adam L.; Herro, Rana; Jabri, Bana; Wilson, Ian A.; Teyton, Luc (Scripps); (UC)

2010-07-22T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

DOI-BLM-NV-C010-2010-0010-EA | Open Energy Information  

Open Energy Info (EERE)

EA EA Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home NEPA Document Collection for: DOI-BLM-NV-C010-2010-0010-EA EA at Dixie Valley Geothermal Area for Geothermal/Exploration Coyote Canyon and Dixie Meadows Geothermal Exploration General NEPA Document Info Energy Sector Geothermal energy Environmental Analysis Type EA Applicant Terra-Gen Power LLC Consultant CH2M Hill Ltd Geothermal Area Dixie Valley Geothermal Area Project Location Nevada Project Phase Geothermal/Exploration Techniques Downhole Techniques, Drilling Techniques, Exploration Drilling, Well Testing Techniques Time Frame (days) Application Time 265 Participating Agencies Lead Agency BLM Funding Agency none provided Managing District Office Carson City Managing Field Office Stillwater

342

Evaluation of a bioluminescent mouse model expressing aromatase PII-promoter-controlled luciferase as a tool for the study of endocrine disrupting chemicals  

SciTech Connect (OSTI)

Dysfunction of the enzyme aromatase (CYP19) is associated with endocrine pathologies such as osteoporosis, impaired fertility and development of hormone-dependent cancers. Certain endocrine disrupting chemicals affect aromatase expression and activity in vitro, but little is known about their ability to do so in vivo. We evaluated a bioluminescent mouse model (LPTA (registered)) CD-1-Tg(Cyp19-luc)-Xen) expressing luciferase under control of the gonadal aromatase pII promoter as an in vivo screening tool for chemicals that may affect aromatase expression. We studied the effects of forskolin, pregnant mare serum gonadotropin and atrazine in this model (atrazine was previously shown to induced pII-promoter-driven aromatase expression in H295R human adrenocortical carcinoma cells). About 2-4 out of every group of 10 male or female Cyp19-luc mice injected i.p. with 10 mg/kg forskolin had increased gonadal bioluminescence after 3-5 days compared to controls; the others appeared non-responsive. Similarly, about 4 per group of 9 individual females injected with pregnant mare serum gonadotropin had increased ovarian bioluminescence after 24 h. There was a statistically significant correlation between ovarian bioluminescence and plasma estradiol concentrations (n = 14; p = 0.022). Males exposed to a single dose of 100 mg/kg or males and females exposed to 5 daily injections of 30 mg/kg atrazine showed no change in gonadal bioluminescence over a 7 day period, but a significant interaction was found between atrazine (100 mg/kg) and time in female mice (p < 0.05; two-way ANOVA). Ex vivo luciferase activity in dissected organs was increased by forskolin in testis, epididymis and ovaries. Atrazine (30 mg/kg/day) increased (30%) luciferase activity significantly in epididymis only. In conclusion, certain individual Cyp19-luc mice are highly responsive to aromatase inducers, suggesting this model, with further optimization, may have potential as an in vivo screening tool for environmental contaminants.

Rivest, Patricia, E-mail: patricia.rivest@iaf.inrs.ca; Devine, Patrick J., E-mail: patrick.devine@iaf.inrs.ca; Sanderson, J. Thomas, E-mail: thomas.sanderson@iaf.inrs.c

2010-11-15T23:59:59.000Z

343

Developmental defects and genomic instability after x-irradiation of wild-type and genetically modified mouse pre-implantation and early post-implantation embryos  

Science Journals Connector (OSTI)

Results obtained from the end of the 1950s suggested that ionizing radiation could induce foetal malformations in some mouse strains when administered during early pre-implantation stages. Starting in 1989, data obtained in Germany also showed that radiation exposure during that period could lead to a genomic instability in the surviving foetuses. Furthermore, the same group reported that both malformations and genomic instability could be transmitted to the next generation foetuses after exposure of zygotes to relatively high doses of radiation. As such results were of concern for radiation protection, we investigated this in more detail during recent years, using mice with varying genetic backgrounds including mice heterozygous for mutations involved in important cellular processes like DNA repair, cell cycle regulation or apoptosis. The main parameters which were investigated included morphological development, genomic instability and gene expression in the irradiated embryos or their own progeny. The aim of this review is to critically reassess the results obtained in that field in the different laboratories and to try to draw general conclusions on the risks of developmental defects and genomic instability from an exposure of early embryos to moderate doses of ionizing radiation. Altogether and in the range of doses normally used in diagnostic radiology, the risk of induction of embryonic death and of congenital malformation following the irradiation of a newly fertilised egg is certainly very low when compared to the 'spontaneous' risks for such effects. Similarly, the risk of radiation induction of a genomic instability under such circumstances seems to be very small. However, this is not a reason to not apply some precaution principles when possible. One way of doing this is to restrict the use of higher dose examinations on all potentially pregnant women to the first ten days of their menstrual cycle when conception is very unlikely to have occurred (the so-called ten-day rule), as already recommended by the Health Protection Agency. Such a precautionary attitude would also be supported by the uncertainties associated with later changes in gene expression which might result from irradiation or early embryos with moderate doses.

P Jacquet

2012-01-01T23:59:59.000Z

344

Integrated Weed Control for Land Stewardship at Legacy Management's Rocky Flats Site in Colorado - 13086  

SciTech Connect (OSTI)

Land stewardship is one of nine sustainability programs in the U.S. Department of Energy's Environmental Management System. Land stewardship includes maintaining and improving ecosystem health. At the Rocky Flats Site near Westminster, Colorado, land stewardship is an integral component of the Office of Legacy Management's post-closure monitoring and management at the site. Nearly 263 hectares (650 acres) were disturbed and re-vegetated during site cleanup and closure operations. Proactive management of revegetation areas is critical to the successful reestablishment of native grasslands, wetlands, and riparian communities. The undisturbed native plant communities that occur at the site also require active management to maintain the high-quality wetlands and other habitats that are home to numerous species of birds and other wildlife such as elk and deer, rare plant communities, and the federally listed threatened Preble's meadow jumping mouse. Over the past several decades, an increase of Noxious weeds has impacted much of Colorado's Front Range. As a result, weed control is a key component of the land stewardship program at Rocky Flats. Thirty-three species of state-listed Noxious weeds are known to occur in the Central and Peripheral Operable Units at Rocky Flats, along with another five species that are considered invasive at the site. Early detection and rapid response to control new invasive species is crucial to the program. An integrated weed control/vegetation management approach is key to maintaining healthy, sustainable plant communities that are able to resist Noxious weed invasions. Weed mapping, field surveys, and field-staff training sessions (to learn how to identify new potential problem species) are conducted to help detect and prevent new weed problems. The integrated approach at Rocky Flats includes administrative and cultural techniques (prevention), mechanical controls, biological controls, and chemical controls. Several species of biocontrol insects have been released to assist with control of different target weed species. Monitoring is conducted to evaluate the effectiveness of control efforts and to provide information for future control efforts. The effective implementation of this integrated approach has reduced the infestation levels of many species and has kept several newly discovered invasive species from spreading and becoming larger problems at the site. (authors)

Nelson, Jody K. [Stoller LMS Team, Contractor to the U.S. Department of Energy Office of Legacy Management, 11025 Dover Street, Suite 1000, Westminster, Colorado 80021 (United States)] [Stoller LMS Team, Contractor to the U.S. Department of Energy Office of Legacy Management, 11025 Dover Street, Suite 1000, Westminster, Colorado 80021 (United States)

2013-07-01T23:59:59.000Z

345

Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740  

Science Journals Connector (OSTI)

Abstract LY379268 and LY354740, two agonists of mGlu2/3 metabotropic glutamate receptors, display different potencies in mouse models of schizophrenia. This differential effect of the two drugs remains unexplained. We performed a proteomic analysis in cultured cortical neurons challenged with either LY379268 or LY354740. Among the few proteins that were differentially influenced by the two drugs, Rab GDP dissociation inhibitor-? (Rab GDI?) was down-regulated by LY379268 and showed a trend to an up-regulation in response to LY354740. In cultured hippocampal neurons, LY379268 selectively down-regulated the ? isoform of Rab GDI. Rab GDI inhibits the activity of the synaptic vesicle-associated protein, Rab3A, and is reduced in the brain of schizophrenic patients. We examined the expression of Rab GDI in mice exposed to prenatal stress (PRS mice), which have been described as a putative model of schizophrenia. Rab GDI? protein levels were increased in the hippocampus of PRS mice at postnatal days (PND)1 and 21, but not at PND60. At PND21, PRS mice also showed a reduced depolarization-evoked [3H]d-aspartate release in hippocampal synaptosomes. The increase in Rab GDI? levels in the hippocampus of PRS mice was reversed by a 7-days treatment with LY379268 (1 or 10mg/kg, i.p.), but not by treatment with equal doses of LY354740. These data strengthen the validity of PRS mice as a model of schizophrenia, and show for the first time a pharmacodynamic difference between LY379268 and LY354740 which might be taken into account in an attempt to explain the differential effect of the two drugs across mouse models.

Rosamaria Orlando; Marina Borro; Marta Motolese; Gemma Molinaro; Sergio Scaccianoce; Alessandra Caruso; Luigi di Nuzzo; Filippo Caraci; Francesco Matrisciano; Anna Pittaluga; Jerome Mairesse; Maurizio Simmaco; Robert Nistic; James A. Monn; Ferdinando Nicoletti

2014-01-01T23:59:59.000Z

346

Controlling the velocity of jumping nanodroplets via their initial shape and temperature  

SciTech Connect (OSTI)

Controlling the movement of nanoscale objects is a significant goal of nanotechnology. Dewetting-induced ejection of nanodroplets could provide another means of achieving that goal. Molecular dynamics simulations were used to investigate the dewetting-induced ejection of nanoscale liquid copper nanostructures that were deposited on a graphitic substrate. Nanostructures in the shape of a circle, square, equilateral, and isosceles triangle dewet and form nanodroplets that are ejected from the substrate with a velocity that depends on the initial shape and temperature. The dependence of the ejected velocity on shape is ascribed to the temporal asymmetry of the mass coalescence during the droplet formation; the dependence on temperature is ascribed to changes in the density and viscosity. The results suggest that dewetting induced by nanosecond laser pulses could be used to control the velocity of ejected nanodroplets.

Fuentes-Cabrera, Miguel A [ORNL; Rhodes, Bradley H [ORNL; Baskes, Mike I. [Los Alamos National Laboratory (LANL); Terrones Maldonado, Humberto [ORNL; Fowlkes, Jason Davidson [ORNL; Simpson, Michael L [ORNL; Rack, Philip D [ORNL

2011-01-01T23:59:59.000Z

347

Vertical jumping in Galago senegalensis: the quest for an obligate mechanical power amplifier  

Science Journals Connector (OSTI)

...of the positive and negative power peaks calculated for the midfoot...factor. However, the positive power deliv- ered by the aponeurosis...to the overall instantaneous power peak (compare gures 5 and 6...fast extension of the distal foot segments is to ensure prolonged...

1998-01-01T23:59:59.000Z

348

Jump-Starting Zero Energy Home Design and Student Careers | Department...  

Broader source: Energy.gov (indexed) [DOE]

The competition provides students with the skills and experience to be leaders in sustainable home design. Students will develop cost-effective zero energy ready home designs...

349

Design and characterization of a compliant-joint robotic jumping leg  

E-Print Network [OSTI]

Biological systems employ compliant joints to allow robust contact with the surroundings and to increase locomotive efficiency. In this experiment, we designed a three-link robotic leg with a compliant calf tendon that was ...

Wang, Albert Duan

2010-01-01T23:59:59.000Z

350

An example of a jump from chaos to integrability for magnetic geodesic flows  

E-Print Network [OSTI]

It is proved that the motion of a charge particle on a hyperbolic oriented two-dimensional surface in a magnetic field given by the volume form of the hyperbolic metric is completely integrable on the energy levels E 1/2 are Anosov flows

I. A. Taimanov

2005-03-01T23:59:59.000Z

351

Evidence for a vertebrate catapult: elastic energy storage in the plantaris tendon during frog jumping  

Science Journals Connector (OSTI)

...Systems Inc., Chelmsford, MA, USA). These bones were registered to the markers using custom scripts [7] for Maya 2009 (Autodesk, Inc., San Rafael, CA, USA). The motion of the fuzed tarsal bones relative to tibiofibula was quantified in all six...

2012-01-01T23:59:59.000Z

352

Airflow elicits a spider's jump towards airborne prey. II. Flow characteristics guiding behaviour  

Science Journals Connector (OSTI)

...airflows imitating the natural flows occuring during phases I and II of the fly-generated...figure 9 a,b. Similar to the sound radiation of the blowfly, the first harmonic contained...nicely resembled that of phase I of the naturally generated fly flow and of the complete...

2013-01-01T23:59:59.000Z

353

Unsteady motion: escape jumps in planktonic copepods, their kinematics and energetics  

Science Journals Connector (OSTI)

...different systems for steady propulsion (feeding appendages) and...number is in the range of peak propulsion efficiency, again suggesting...dominating mesozooplankton group in marine plankton and are maybe the...theory rather predicts that propulsion velocity should scale with...

2010-01-01T23:59:59.000Z

354

Experiments on Hydraulic Jumps in Turbidity Currents Near a Canyon-Fan Transition  

Science Journals Connector (OSTI)

...attention. Recently Parker, Fukushima, and Pantin (11) have...sediment by-passing put forward by Mutti (19). The...11. G. Parker, Y. Fukushima, H. Pantin, ibid. 171, 145 (1986). 12. Y. Fukushima, G. Parker, H. Pantin...

MARCELO GARCIA; GARY PARKER

1989-07-28T23:59:59.000Z

355

e n e r g y When Oil Prices Jump, Is Speculation To Blame?  

E-Print Network [OSTI]

Historically, the long-run primary driver of oil prices has been global demand. 1 An expanding global economy demands more raw inputs, including oil, and that increased demand pushes up their price. However, the past decade (2000-09) saw a rapid proliferation in the financialization of commodities, i.e., the creation and trading of financial instruments indexed to commodity prices. Estimates indicate that assets allocated to commodity index trading rose from $13 billion in 2004 to $260 billion in March 2008. Many people, including policymakers and economists, have posited

Brett Fawley; Luciana Juvenal; Ivan Petrella

356

The Inverting Effect of Curvature in Winter Terrain Park Jump Takeoffs J. A. McNeil  

E-Print Network [OSTI]

Ackery, et al. [6] found evidence of an increasing incidence of traumatic brain injury and spinal cord

357

On the pointwise jump condition at the free boundary in the 1-phase ...  

E-Print Network [OSTI]

O = {x ? Rn : t(x) is continuous at x, and ? lim r?0. ? ... quence in O ?Z such that limk?? xk = x ? O. Because x is a point of .... ties of the free boundary, Calc

2004-02-09T23:59:59.000Z

358

CUNY Unit Project Name Baruch Jump-starting Veterans' Career Success  

E-Print Network [OSTI]

in Leadership in Transportation Industry SPS HIM York Onsite RN-BSN Program at North Shore LIJ Forest Hills Page

Rosen, Jay

359

NOAAINMFS Developments U.S. Commercial Fish Landings Jump in 1976  

E-Print Network [OSTI]

increase in food fish catches and to generally rising prices. The Commerce Department agency says for processing into meal and oil also appear 10 be above the 1975 levels. Increased production of Atlan- Scientists will collect and analyze histori- cal information on harvesting, fishing ef- fort, and natural

360

A SEMI-LAGRANGIAN APPROACH FOR AMERICAN ASIAN OPTIONS UNDER JUMP DIFFUSION  

E-Print Network [OSTI]

oil based on its average price instead of its spot price. For a historical review of Asian options we.A. FORSYTH, AND G. LABAHN§ Abstract. A semi-Lagrangian method is presented to price continuously observed a payoff that depends on the average price of the underlying asset over a speci£ed period of time (12

Labahn, George

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Electrostatic charging of jumping droplets on superhydrophobic nanostructured surfaces : fundamental study and applications  

E-Print Network [OSTI]

Condensation is a ubiquitous process often observed in nature and harnessed in many industrial processes such as power generation, desalination, thermal management, and building environmental control. Recent advancements ...

Preston, Daniel J. (Daniel John)

2014-01-01T23:59:59.000Z

362

Experiments on Hydraulic Jumps in Turbidity Currents Near a Canyon-Fan Transition  

Science Journals Connector (OSTI)

...cathodoluminescence ex-periments. Many useful comments on our manu-script were made by K. Kash, J. M. Worlock, and M. Saifi. We are especially gratefill to D. E. Aspnes for making concrete suggestions for the improvement ofour report. 8 May 1989...

MARCELO GARCIA; GARY PARKER

1989-07-28T23:59:59.000Z

363

Navigate MathSciNet Jump to Search or Browse Screens  

E-Print Network [OSTI]

, 455­467. 58F11 (58F18) References: 0 Reference Citations: 1 Review Citations: 0 For a C1+ -action (0

Hurder, Steven

364

Mouse Strain-Dependent Variations in Sensitivity to Induction of Gamma-H2AX Foci after Continuous Low Dose-Rate Irradiation: The Atm-/- vs Atm +/+ genotypes on Balb/c, 129S6, C57BL/6J, and A/J inbred strains  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Mouse Strain-Dependent Variations in Sensitivity to Induction of Gamma-H2AX Foci Mouse Strain-Dependent Variations in Sensitivity to Induction of Gamma-H2AX Foci after Continuous Low Dose-Rate Irradiation: The Atm-/- vs Atm +/+ genotypes on Balb/c, 129S6, C57BL/6J, and A/J inbred strains. J.R.Brogan 1 , H. Nagasawa 1 , T.A Kato 1 , C.Fallgren 1 , T.Wade 1 . P.Genik 1 , J.B.Little 2 , J.S.Bedford 1 , and M.M.Weil 1 1 Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523; 2 Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston MA 02115 We have recently developed a 'low dose rate' gamma-H2AX assay that is sufficiently sensitive to distinguish differences in response for cells from normal Atm +/+ (mouse) or ATM+/+ (human) and the phenotypes associated with the corresponding

365

Appendix 42 Streams in the Flathead Subbasin that contain brook trout as of  

E-Print Network [OSTI]

Creek Meadow Creek Miller Creek Nelson Creek Paul Creek Plume Creek Potter Creek Reid Creek Robertson

366

UCUT Wildlife Monitoring and Evaluation Project (UWMEP): a Regional Approach  

E-Print Network [OSTI]

- steppe Grassland steppe Conifer Woodland Mixed Conifer Riparian Forest Riparian Shrub Wetland Meadow

367

Winter and summer nitrous oxide and nitrogen oxides fluxes from a seasonally snow-covered subalpine meadow at Niwot Ridge, Colorado  

E-Print Network [OSTI]

of Geography, University of Colorado, Boulder, CO, USA M. W.Alpine Research, University of Colorado, Boulder, CO, USA D.Sciences, University of Colorado, Boulder, CO, USA B. Hall

2009-01-01T23:59:59.000Z

368

PRE-MATING COMMUNICATION AND HYBRIDIZATION BETWEEN TWO MEADOW KATYDIDS, ORCHELIMUM NIGRIPES AND O. PULCHELLUM (ORTHOPTERA: TETTIGONIIDAE): MALE CALLING SONG AND ASYMMETRIC FEMALE PREFERENCE  

E-Print Network [OSTI]

the hybrid zone were characterized in two ways, song (Chapter 1) and mitochondrial DNA (mtDNA, Chapter 2). Songs from hybrid populations collected within the zone differed in temporal patterning from songs of allopatric Orchelimum nigripes and O. pulchellum...

Miller, Ginger

2010-12-06T23:59:59.000Z

369

After a Storm  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

After a Storm After a Storm Nature Bulletin No. 47 January 5, 1946 Forest Preserve District of Cook County Clayton F. Smith, President Roberts Mann, Superintendent of Conservation AFTER A STORM At daybreak on Monday, December 24, a blinding blizzard raged. About eight o'clock the snow ceased. Immediately the woods and meadows became alive with hungry animals and birds. The rabbits came out of their snug hiding places to cruise the thickets, gnawing the bark of young trees and shrubs, or racing about for exercise and play. The squirrels came down from their den trees and zigzagged here and there, digging out acorns from beneath the snow. The killers of the foxes, mink and weasel -- came out hunting for mice and any luckless bird or animal they could surprise. Everywhere in the tall grass and weeds of the meadows, the field mice had made telltale holes from their runways up to the surface, for air. Flocks of song sparrows hopped about, jumping up to seize the choice weed seeds. Pheasants stalked along, eating seeds and hunting patches of burdock or nubbins left in cornfields, where they could get a real meal. The juncoes cleaned up what the pheasants wasted.

370

Gamma irradiation of the prenatal mouse dentition  

E-Print Network [OSTI]

as the dental lamina to the stage of the deposition of enamel and dentin. The purpose of this study was to determine the effect of a continuous stress of gamma irradiation on the structure of the odontogenic cells, the relative size and rate of development... development. In 1927, Leist (9) made a study of the effect of X-rays on teeth, which was brought about by the following rase. A worker in a Roentgen tube factory was exposed daily to a considerable dose of X-irradiation. Sometime later he began to show...

Kerley, Michael Auston

1969-01-01T23:59:59.000Z

371

Cellular fusion in the mouse intestine.  

E-Print Network [OSTI]

??Tissue regeneration after injury poses a major challenge that requires the fine balance between stimulation and dysregulation of cell proliferation in order to facilitate homeostatic (more)

Powell, Anne Elizabeth

2010-01-01T23:59:59.000Z

372

Regression Kinetics of Mouse Skin Papillomas  

Science Journals Connector (OSTI)

...stronger tendency to regress. Roe et al. (8) have published...Skocik. APRIL 1976 1425 F. J. Burns et a!. REFERENCES 1. Berenblum...40: 823-846, 1968. 8. Roe, F. J. C., Carter, R...9. Salaman, M. H., and Roe, R. J. C. Carcinogenesis...

Fredric J. Burns; Martin Vanderlaan; Andrew Sivak; and Roy E. Albert

1976-04-01T23:59:59.000Z

373

Mysteries around the graph Laplacian eigenvalue 4 Yuji Nakatsukasa1  

E-Print Network [OSTI]

from the eigen- value 0 up to 4. Then, at the eigenvalue 4, there is a sudden jump as shown in Figure 1 Laplacian eigen- value distributions. (a) 2D projection of dendrites of an RGC of a mouse; (b to the eigenvalues below 4 are semi-global oscillations (like Fourier modes) over the entire tree or one

Saito, Naoki

374

Salivary Alpha-Amylase as an Indicator of Body Stress Following an Acute Session of Repetitive Jumping.  

E-Print Network [OSTI]

??Determining body stress levels is important when developing training programs for athletes and rehab facilities. Stress levels during exercise are commonly measured using heart rate, (more)

Allen, Shaelee

2014-01-01T23:59:59.000Z

375

Detection of nanosecond time scale side-chain jumps in a protein dissolved in water/glycerol solvent  

E-Print Network [OSTI]

a positive identification of nanosecond dynamics in Val-23 where ns motions were already observed earlier. In several other cases, however, only tentative identification was possible. The lack of definitive results. In particular, it has been found that the overall protein tumbling is controlled by the bulk solvent

Skrynnikov, Nikolai

376

Patterns of spread in biological invasions dominated by long-distance jump dispersal: Insights from Argentine ants  

Science Journals Connector (OSTI)

...1997) 1 3 30 Central-south Portugal Oak plantation 29 Holway (1998)? 20 34 049...demonstrate that queens with as few as 10 workers exhibit high rates of colony growth, suggesting...Zuparko) California State University, North Ridge* (James Hogue) Cincinnati Museum Center...

Andrew V. Suarez; David A. Holway; Ted J. Case

2001-01-01T23:59:59.000Z

377

Biomechanical and Neuromuscular Changes in Jump Landings Due to Short or Long Term Ankle Bracing and Fatigue.  

E-Print Network [OSTI]

??In order to prevent ankle sprain, prophylactic ankle bracing is common practice for many sports. The purpose of this dissertation was to investigate changes in (more)

Stafford, Elizabeth Decatur

2012-01-01T23:59:59.000Z

378

Jump neural network for online short-time prediction of blood glucose from continuous monitoring sensors and meal information  

Science Journals Connector (OSTI)

Several real-time short-term prediction methods, based on time-series modeling of past continuous glucose monitoring (CGM) sensor data have been proposed with the aim of allowing the patient, on the basis of predicted glucose concentration, to anticipate ... Keywords: Continuous glucose monitoring, Diabetes, Forecast, Non-linear modeling, Signal processing, Time series

C. Zecchin; A. Facchinetti; G. Sparacino; C. Cobelli

2014-01-01T23:59:59.000Z

379

Kinetics and Mechanisms of Molybdate Adsorption/Desorption at the Goethite/Water Interface Using Pressure-Jump Relaxation  

E-Print Network [OSTI]

Kinetics and Mechanisms of Molybdate Adsorption/Desorption at the Goethite/Water Interface Using/desorption on goethite. A postulated reaction mechanism consisting of two consecutive elementary steps was examined of ionic species on the goethite surface, in the a and 0 layers, and in the bulk solution at equilibriumand

Sparks, Donald L.

380

Thermal And-Or Near Infrared At Railroad Valley Area (Laney, 2005) | Open  

Open Energy Info (EERE)

Railroad Valley Area (Laney, 2005) Railroad Valley Area (Laney, 2005) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Thermal And-Or Near Infrared At Railroad Valley Area (Laney, 2005) Exploration Activity Details Location Railroad Valley Area Exploration Technique Thermal And-Or Near Infrared Activity Date Usefulness useful DOE-funding Unknown Notes Geology and Geophysics of Geothermal Systems, Gregory Nash, 2005. Objectives for FY 2004 were to map mineralogy in Dixie Meadows, NV and thermal anomalies in Railroad Valley, NV. The first objective relates to the project goal of testing hyperspectral imagery for applications in soil-mineralogy mapping to detect hidden faults and buried geothermal phenomena. The second objective relates to testing satellite thermal

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Zim's Hot Springs Pool & Spa Low Temperature Geothermal Facility | Open  

Open Energy Info (EERE)

& Spa Low Temperature Geothermal Facility & Spa Low Temperature Geothermal Facility Jump to: navigation, search Name Zim's Hot Springs Pool & Spa Low Temperature Geothermal Facility Facility Zim's Hot Springs Sector Geothermal energy Type Pool and Spa Location New Meadows, Idaho Coordinates 44.9712808°, -116.2840176° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[]}

382

Jim's Hot Springs Pool & Spa Low Temperature Geothermal Facility | Open  

Open Energy Info (EERE)

Jim's Hot Springs Pool & Spa Low Temperature Geothermal Facility Jim's Hot Springs Pool & Spa Low Temperature Geothermal Facility Jump to: navigation, search Name Jim's Hot Springs Pool & Spa Low Temperature Geothermal Facility Facility Jim's Hot Springs Sector Geothermal energy Type Pool and Spa Location New Meadows, Idaho Coordinates 44.9712808°, -116.2840176° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[]}

383

Hyperspectral Imaging At Dixie Valley Geothermal Field Area (Laney, 2005) |  

Open Energy Info (EERE)

Imaging At Dixie Valley Geothermal Field Area (Laney, 2005) Imaging At Dixie Valley Geothermal Field Area (Laney, 2005) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Hyperspectral Imaging At Dixie Valley Geothermal Field Area (Laney, 2005) Exploration Activity Details Location Dixie Valley Geothermal Field Area Exploration Technique Hyperspectral Imaging Activity Date Spectral Imaging Sensor AVIRIS Usefulness useful DOE-funding Unknown Notes Geology and Geophysics of Geothermal Systems, Gregory Nash, 2005. Hyperspectral data was also used to successfully map soil-mineral anomalies that are structurally related in Dixie Valley, Nevada. In the area of the power plant, 20 m spatial resolution AVIRIS data were used. For Dixie Meadows, Nevada, 3 m spatial resolution HyVista HyMap hyperspectral data

384

Fact Sheet Fact Sheet Fact Sheet B O N N E V I L L E P O W E  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Red River Meadow conservation easement will protect fish, elk habitat In the heart of the Nez Perce National Forest in north central Idaho, prime meadow habitat serves as early...

385

Spatial patterns of soil salinities in old embanked marshlands in western France  

Science Journals Connector (OSTI)

The spatial pattern of soil salinity was studied in commonly owned grazing meadows, embanked in the distant past (10th century), situated on the Atlantic coast of western France. The meadows were characterized...

Bernard Amiaud; Jan-Bernard Bouzill; Frdric Tournade; Anne Bonis

1998-09-01T23:59:59.000Z

386

Campus Planning Committee February 26, 2013 2:00-4:00 p.m.  

E-Print Network [OSTI]

guestrooms for convenient and affordable accommodation for out-of-town visitors. C. TPL Gift ­ Ocean Meadows

California at Santa Barbara, University of

387

Eleven Tribes Jump START Clean Energy Projects, Summer 2012 (Newsletter), U.S. Department of Energy (DOE) Office of Indian Energy (OIE), Indian Energy Beat  

Broader source: Energy.gov (indexed) [DOE]

BUILDING BUILDING BRIDGES . . . . . . . . . . . . . . . . . . . . . . . 3 SHARING KNOWLEDGE . . . . . . . . . . . . . . . . . . . . . 3 WINNING THE FUTURE . . . . . . . . . . . . . . . . . . . . . . 3 ON THE HORIZON . . . . . . . . . . . . . . . . . . . . . . . . . 4 LEADING THE CHARGE . . . . . . . . . . . . . . . . . . . . . 4 "Tribal communities, entrepreneurs, and small businesses will benefit greatly from the technical resources and expertise provided by DOE. START will help Native American and Alaska Native communities increase local generation capacity, enhance energy efficiency and conservation measures, and create job opportunities in the new clean energy economy." -DOE-IE Director Tracey A. LeBeau The U.S. Department of Energy Office of Indian Energy Policy and Programs (DOE-IE) has selected 11 Tribes-five in Alaska and six in the contiguous United States-to receive on-the-ground technical support for community-based energy efficiency and renewable

388

A model study of the effect of bucket dentations on a ski-jump spillway jet: with a mathematical analysis of critical bucket radius determination.  

E-Print Network [OSTI]

- tute for an energy dissipator. Its primary purpose is merely to throw the water downstream to a place where the scour which is certain to occur will not constitute a danger to the dam (or the bucket itself if it is separate from the dam), the river... to the surface area of the jet and the square of the relative velocity of the jet to the air. ~~ The final product of an efficient dissipation of energy, using a jet trajectory as the xnethod, will be a spray instead of a concentrated jet. This occurence may...

Gladwell, John Stuart

2012-06-07T23:59:59.000Z

389

Expression of esterase-2 in developing mouse embryos and neonates  

E-Print Network [OSTI]

as maternal invironments in which the gene product can be assayed. The esterase-2 gene product (ES-2) was purified by means of isoelectric foc- using and gel filtration of C57BL/6J kidney homogenates. Purified ES-2 was used to elicit antisera from New... in kidney. . Page 28 LIST OF FIGURES Page 1. Heat curves. 14 2. Immunoelectrophoretic rockets of purified ES-2. 15 3. Rocket areas vs. purified ES-2. 16 4. Starch gel of purified ES-2 18 5. Crossed electrophoresis 19 6. Immunoelectrophoretic...

Deal, Frank Hans

1981-01-01T23:59:59.000Z

390

Static and dynamic tactile directional cues experiments with VTPlayer mouse  

E-Print Network [OSTI]

, is a track- ball: the braille cell replaces the scrolling wheel. The second one is called Tacti] added a 2?4 braille cell on three devices to add tactile information. The first one, called TactiBall

Paris-Sud XI, Université de

391

Ethanol Promotes Intestinal Tumorigenesis in the MIN Mouse  

Science Journals Connector (OSTI)

Short Communications Ethanol Promotes Intestinal Tumorigenesis in...Twenty-four MIN mice were randomized to ethanol supplementation in the drinking water...a mutagenic adduct associated with ethanol consumption. Ethanol supplementation...

Hemant K. Roy; James M. Gulizia; William J. Karolski; Anne Ratashak; Michael F. Sorrell; Dean Tuma

2002-11-01T23:59:59.000Z

392

The evaluation of add-on mouse pads using electromyography  

E-Print Network [OSTI]

cori teat e terieott as seen in Table 2, however, this was as a result of the gender by treatment interaction, meaning the genders responded differently to the treatments as seen in Table 3. TABLE 2 Time F value (Hrs'l 0 048 2 182 4 198 6 418... Overall Treatment Effects on the Trapezius Pr & F Significance 0 7077 ns 02441 ni 0 2178 ns 0 0643 ns TABLE 3 Time F value (Hts) 0 93 1 69 762 5 77 Gender by Treatment Effects on the Trapezius Pr & F Significance 0 4812 ns 0 2673 ns 0...

Thomas, Varghese

2012-06-07T23:59:59.000Z

393

Mouse immunoglobulin D: messenger RNA and genomic DNA sequences  

Science Journals Connector (OSTI)

...a-helical or a, 8-pleated sheet conformation. Very similar...0.971.912 0.973, 8-Sheet potential (Ps) 1.045 1...phase; AG is the change in free energy in kilo-calories per mole...will initiate, 8-pleated sheet formations; values > 1.000...

PW Tucker; CP Liu; JF Mushinski; FR Blattner

1980-09-19T23:59:59.000Z

394

RAPID/Best Practices/Memorandums of Understanding (MOUs) for...  

Open Energy Info (EERE)

In some cases, the development of an MOU (particularly negotiation of the MOU terms) has been viewed as a distraction that prevented the project from move forward in a...

395

The development of direction selectivity in the mouse retina  

E-Print Network [OSTI]

firing of starburst amacrine cells and DSGCs, is not necessary to establish the retinal circuitsfiring rate in the null direction is as low as in adult, indicating that the circuits

Elstrott, Justin Blake

2009-01-01T23:59:59.000Z

396

Characterization of Neuropeptide Y Expressing Cells in the Mouse Retina  

E-Print Network [OSTI]

present in two layers, the inner nuclear layer (INL) and the ganglion cell layer (GCL). The cells in both layers were densely distributed, with those in the INL having a mean density of 1452 65 cells/mm2 , and those in the GCL having a mean density of 644 41 cells/mm2 . The cells in the INL extended

Nirenberg, Sheila

397

Control of Adenosine Monophosphate Catabolism in Mouse Ascites Tumor Cells  

Science Journals Connector (OSTI)

...relationship was noted between the energy charge value and the rate of...Animals Deoxyglucose pharmacology Energy Metabolism drug effects Glucose...phosphate and the adenine nucleo- tides were measured at several time...intracellular AMP, decreased the energy charge, and either decreased...

Leonard A. Sauer

1978-04-01T23:59:59.000Z

398

Laminar circuit organization and response modulation in mouse visual cortex  

E-Print Network [OSTI]

1.25 NaH2PO4, 4 MgCl2, 0.5 CaCl2, and 24 NaHCO3). SlicesNaCl, 2.5 KCl, 26 NaHCO3, 2 CaCl2, 2 MgCl2, 1.25 NaH2PO4,

Olivas, Nicholas D; Quintanar-Zilinskas, Victor; Nenadic, Zoran; Xu, Xiangmin

2012-01-01T23:59:59.000Z

399

Observations on feeding behavior in the vesper mouse, Nyctomys sumichrasti  

E-Print Network [OSTI]

47C119C119C119C46C117C114C98C97C110C102C105C115C99C104C101C114C46C100C101C47C106C111C117C114C110C97C108C115C47C109C97C109C109C98C105C111C108 C90C101C105C116C115C99C104C114C105C102C116 C102C117C200C114C83C97C200C117C103C101C116C105C101C114C107C117C110C... C97C115C44 C76C97C119C114C101C110C99C101C44 C75C97C110C115C97C115C59C68C101C112C97C114C116C109C101C110C116 C111C102C70C111C114C101C115C116C114C121C44C77C105C99C104C105C103C97C110C83C116C97C116C101 C85C110C105C118C101C114C115C105C116C121C44C69C97C115C...

Timm, Robert M.; Vriesendorp, Corine

2003-04-01T23:59:59.000Z

400

Morphine sulfate stimulates the adenylate cyclase in mouse caudate nuclei  

Science Journals Connector (OSTI)

...narcotics and the endogenous opioid polypeptides. This work was supported by U.S. National Institutes of Health Grant NS 12776, the late Mrs. Jean Mauze, the Charles E. Merrill Trust, the American Parkinson's Disease Association, and Mrs. Katherine...

L C Tang; G C Cotzias

1978-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Glove Mouse Project The goal of this project  

E-Print Network [OSTI]

that is cost-effective,easy to use, and portable. Hybrid, High-performance Cluster Computer Setup The objective it to create a viable fuel for use in a diesel engine. Multi-Functional Automated Turret Stand alone turret Design and implementation of an unmanned aerial vehicle which is capable of autonomous control via

de Lijser, Peter

402

Substrate reduction therapy in mouse models of the glycosphingolipidoses  

Science Journals Connector (OSTI)

...Neufeld 1991). The substrate for the defective enzyme accumulates in the lysosome and...progressively accumulates, leading to renal and car- diovascular disease in hemizygous males...M1)-ganglioside accumulation in mice defective in lysosomal acid beta- galactosidase...

2003-01-01T23:59:59.000Z

403

Developmental transitions of germ cell lineage of the mouse  

E-Print Network [OSTI]

Mammalian germ cells arise during early embryogenesis and migrate to the developing gonad where, under the direction of the somatic environment, they initiate distinct sex-specific developmental programs resulting in the ...

Baltus, Andrew Edmund

2006-01-01T23:59:59.000Z

404

The organizer factors Chordin and Noggin are required for mouse  

E-Print Network [OSTI]

by distinctly separated cell populations1,2 . The head organizer is located in the anterior visceral endoderm (AVE) and the trunk organizer in the node and anterior primitive streak. In amphibians, Spemann's organi- zer, which is homologous to the node, partially overlaps with anterior endoderm cells expressing

De Robertis, Eddy M.

405

The proteome of mouse brain microvessel membranes and basal lamina  

E-Print Network [OSTI]

IPI00849927 IPI00113377 Gene Vim Mbp Lrp1 Gnaq Ahnak AlcamIPI00319830.7 IPI00115564.5 Aco2 Vim Tubb3 Ncam1 Gnao1 Mdh2

Chun, Hyun Bae

2011-01-01T23:59:59.000Z

406

C3Bio.org - Tags: wireless mouse  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

The Great Pyramid is found in... - Select an answer - Egypt Japan Canada Rocks The North Pole Please leave this field blank. required Problem: required Attach a screenshot:...

407

Interferon-Stimulated Genes in the Pregnant Mouse Uterus  

E-Print Network [OSTI]

on for eac h respe ctive g ene. L E, luminal e pithel ium; G E, glan dula r e pitheli um; D ,d eci du a. D D D D LE LE LE GE D LE 18 FIG. 4. ISH analysis of Isg1 5, Nm i, O as2 , a nd Plsc r1 in e ndom etria an d con ceptuse... GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994, 264(5164):1415- 1421. 27. Ritchie KJ, Hahn CS, Kim KI, Yan M, Rosario D, Li L, de la Torre JC, Zhang DE: Role of ISG...

Tilford, Sarah

2008-08-24T23:59:59.000Z

408

A Systematic Analysis of a Deep Mouse Epididymal Sperm Proteome...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

energy production via glycolysis, ?-oxidation and oxidative phosphorylation, protein folding and transport, and cell signaling systems. This proteome should prove a useful...

409

ISOLATION AND CHARACTERISATION OF SYNAPTIC VESICLES FROM MOUSE BRAIN  

E-Print Network [OSTI]

vesicles 64 3.6.2 Synaptic vesicle fusion 65 3.7 Analysis of subcellular fractions from Rab-GDI 1 KO mice 75 4.4 Effects of Rab-GDI1 deletion o

Jahn, Reinhard

410

Neurogenomics in the mouse model : multivariate statistical methods and analyses  

E-Print Network [OSTI]

Irwin, Inc. , Illinois. Rademakers R, Sleegers K, Theuns J,2001; Melchor et al. 2003; Rademakers et al. 2005; Jacobs et

Zapala, Matthew Alan

2007-01-01T23:59:59.000Z

411

Transgenic mouse models of childhood-onset psychiatric disorders  

E-Print Network [OSTI]

Childhood-onset psychiatric disorders, such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), mood disorders, obsessive compulsive spectrum disorders (OCSD), and schizophrenia (SZ), affect ...

Robertson, Holly Rochelle

412

Chloramphenicol: Effects on Mouse Myeloma Cells in Tissue Culture  

Science Journals Connector (OSTI)

...SUSPENSION CULTURE, EXPERIMENTAL CELL RESEARCH 47 : 608 ( 1967 ). SAIDI, P, EFFECT OF CHLORAMPHENICOL ON ERYTHROPOIESIS, JOURNAL...Medicine, St. Louis, Missouri 63110 References and Notes 1. P. Saidi, R. 0. Wallerstein, P. M. Aggeler, J. Lab. Clin. Med...

Boyd K. Hartman; Olive S. Pettengill; George D. Sorenson

1969-07-18T23:59:59.000Z

413

Nicotinamide and Nicotinamide Analogues as Antitumor Promoters in Mouse Skin  

Science Journals Connector (OSTI)

...1 microg of 1alpha,25(OH)2D3 was applied 30 min before 5 microg of TPA, the times...1alpha,25(OH)2D3 at 1 microg was applied at Stage I + II or Stage II, tumor formation...out by an experiment in which TPA was applied to the 1alpha,25(OH)2D3 alone-treated...

Andreas Ludwig; Manfred Dietel; Gity Schfer; Karin Mller; and Helmuth Hilz

1990-04-15T23:59:59.000Z

414

Sodium Transport in a Mouse Model of Colonic Carcinogenesis  

Science Journals Connector (OSTI)

...transport changes in the colonie mucosa of car cinogen-treated CFi mice after 4 weeks...9 1.0Electric potential in mV. ' Conductance in mS...ratios in human cancer cells as revealed by energy dispersive X-ray microanalysis. J...

Richard J. Davies; Wibo F. Weidema; Geoffrey I. Sandle; Lawrence Palmer; Eleanor E. Deschner; and Jerome J. DeCosse

1987-09-01T23:59:59.000Z

415

Monitoring transient repolarization segment morphology deviations in mouse ECG  

E-Print Network [OSTI]

This thesis details the design, implementation and validation of a system that facilitates partial automation for detection of anomalous repolarization segment morphologies in the ECG of mice. The technology consists of ...

Oefinger, Matthew Blake, 1976-

2006-01-01T23:59:59.000Z

416

Amplification and novel locations of endogenous mouse mammary tumor virus genomes in mouse T-cell lymphomas.  

Science Journals Connector (OSTI)

...except that transfers were hybridized to nick-translated PstI-B env probe. The position...MMTV-a genomes. One hypothesis that merits consideration is that MMTV-a sequences...acid to high specific activity in vitro by nick translation with DNA polymerase I. J...

J Dudley; R Risser

1984-01-01T23:59:59.000Z

417

C  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Creek Green Meadows Hazel Dell Park and Trail Heathergate Ridge Walnut Grove Covington Sifton Park Vancouver Lake Vancouver Lake Green Mountain Fort Vancouver Fort Vancouver Nat'l...

418

E-Print Network 3.0 - area ames iowa Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

29 Barn Swallow Breeding habitat usually contains open areas (fields, meadows, farm ponds, marshes, CRP and Summary: . Roosa. 1984. Iowa birds. Iowa State University...

419

Changes in Prehistoric Land Use in the Alpine Sierra Nevada: A Regional Exploration Using Temperature-Adjusted Obsidian Hydration Rates  

E-Print Network [OSTI]

of the Crane Valley Hydroelectric Project Area, Maderaand Balsam Meadow Hydroelectric Project. Report submitted toCaliforniaBishop Creek Hydroelectric Project (FERC Project

Stevens, Nathan E.

2005-01-01T23:59:59.000Z

420

Infographics from the 2014 National Geothermal Student Competition...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Infographics from the 2014 National Geothermal Student Competition Infographics from the 2014 National Geothermal Student Competition Phil Ulibarri of Truckee Meadows Community...

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

E-Print Network 3.0 - alternata pathogenic fungi Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

soil fungi on seeds of meadow plants Michelle Schafer and Peter M. Kotanen* Summary: ; Gilbert 2002 . The existing evidence tends to suggest that seed pathogens, particularly...

422

NREL: Energy Analysis - Ben Maples  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

G.; Maples, B.; Meadows, B.; Hand, M.; Musial, W.; Elkington, C.; Clayton, J. (2012). Offshore Wind Plant Balance-of-Station Cost Drivers and Sensitivities (Poster). NREL...

423

Download - American Society of Limnology and Oceanography  

Science Journals Connector (OSTI)

floating stems with hanging root clusters dur- ing inundation. The floating meadows are es- timated to occupy lo-30% of the floodplain at high water in the...

1999-12-24T23:59:59.000Z

424

Mr. Norman Drubner  

Office of Legacy Management (LM)

Engineer District andor the Atomic Energy commission (AEC) in the early years of nuclear energy development. The site at 414 Meadows Street, Waterbury, Connecticut, known...

425

Weatherking Heating & Air conditioning | Open Energy Information  

Open Energy Info (EERE)

Page Page Edit with form History Facebook icon Twitter icon » Weatherking Heating & Air conditioning Jump to: navigation, search Name Weatherking Heating & Air conditioning Address 51 Meadow Lane Place Northfield, Ohio Zip 44067 Sector Buildings, Efficiency, Geothermal energy, Renewable Energy, Services Product Business and legal services; Energy audits/weatherization; Energy provider: power production;Energy provider: wholesale;Engineering/architectural/design;Installation;Investment/finances;Maintenance and repair; Retail product sales and distribution Phone number 330-908-0281 Website http://www.weatherking1.com Coordinates 41.3340869°, -81.530299° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":41.3340869,"lon":-81.530299,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

426

Property:NEPA Decision | Open Energy Information  

Open Energy Info (EERE)

Decision Decision Jump to: navigation, search Property Name NEPA Decision Property Type Page Description Files documenting decisions on NEPA Docs This is a property of type Page. Pages using the property "NEPA Decision" Showing 25 pages using this property. (previous 25) (next 25) B BLM-NV-WN-ES-08-01-1310, NV-020-08-01 + BLM-NV-WN-ES-08-01-1310 EA DR and FONSI.pdf + D DOE-EA-1621 + CX-001816.pdf + DOE-EA-1733 + CX-002924.pdf + DOE-EA-1961 + Kalispell-Kerr EA Determination Memo.pdf + DOI-BLM-NV-C010-2010-0006-EA + DOI-BLM-NV-W030-2010-0006-EA DECISION.pdf +, DOI-BLM-NV-W030-2010-0006-EA CONDITIONS.pdf + DOI-BLM-NV-C010-2011-0001-EA + Coyote Canyon Decision Record March 2011.pdf + DOI-BLM-NV-C010-2011-0514-EA + DOI-BLM-C010-2011-0514-EA-DR.pdf + DOI-BLM-NV-C010-2011-0516-EA + DixieMeadows DecisionRecord 01 17 12.pdf +

427

Tracks in the Snow  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Tracks in the Snow Tracks in the Snow Nature Bulletin No. 98 January 11, 1947 Forest Preserve District of Cook County William N. Erickson, President Roberts Mann, Superintendent of Conservation TRACKS IN THE SNOW Tracks in the snow tell fascinating stories of the secret lives of the wild animals that are abroad in wintertime -- stories of their search for food and the never-ending warfare between the hunter and the hunted. Walking through the woods, we came upon the trail of a red fox. The footprints of a fox are more pointed than those of a dog, more nearly in a straight line, and the hind foot is placed exactly on the print of the corresponding front foot. More-over, this fox had walked out across a meadow to a big ant hill on top of which he sat to listen and test the wind for scent. A dog will not do that. Later, back in the woods, he had jumped on a fallen tree and trotted along its length. A dog will not do that, either. The fox was traveling leisurely, pausing here and there to sniff at tufts of grass and other possible hiding places for mice.

428

ERDC/ELSR-00-8EnvironmentalLaboratory Aquatic Plant Control Research Program  

E-Print Network [OSTI]

ERDC/ELSR-00-8EnvironmentalLaboratory Aquatic Plant Control Research Program Sediment Resuspension Sediment Resuspension Dynamics in Canopy- and Meadow-Forming Submersed Macrophyte Communities by William F resuspension dynamics in canopy- and meadow-forming submersed macrophyte communities / by John W. Barko

US Army Corps of Engineers

429

Aspen (Populus tremuloides) stands and their contribution to plant diversity in a semiarid coniferous landscape  

E-Print Network [OSTI]

; conifer forest plots were significantly lower in both measures. Heterogeneity in species composition was higher for aspen forest than for meadows or conifer forest, both within sites and between sites. Plant distinct from adjacent meadows and conifer forest, and thataspenforestsare a majorcontributortoplant

Tate, Kenneth

430

Transmission/Resource Library/MOU | Open Energy Information  

Open Energy Info (EERE)

source source History View New Pages Recent Changes All Special Pages Semantic Search/Querying Get Involved Help Apps Datasets Community Login | Sign Up Search Page Edit History Facebook icon Twitter icon » Transmission/Resource Library/MOU < Transmission‎ | Resource Library Jump to: navigation, search ResourceLibraryHeader.png Public Involvement Resources GIS Tools and Maps Environmental Resources and Mitigation NEPA MOUs General Transmission Documents Transmission Dashboard Permitting Atlas Compare States Arizona California Colorado Idaho Montana Nevada New Mexico Oregon Utah Washington Wyoming Resource Library NEPA Database Memorandums of Understanding (MOUs)for Interstate Transmission Projects Multi-state transmission siting and permitting projects benefit from effective collaboration between government entities, tribes, project

431

A Congenic Line of the BALB/c Mouse Strain with the Endogenous Mouse Mammary Tumor Virus Proviral Gene Mtv-3: Tissue-specific Expression and Correlation with Resistance to Mouse Mammary Tumor Virus Infection and Tumorigenesis  

Science Journals Connector (OSTI)

...N-methyl-N-nitro-N-nitrosoguanidine by three exposure routes at different developmental...12-dimethylbenzanthracene by two exposure routes at different developmental...human rhabdomyosarcoma cell lines and tumour samples. J Pathol...pancreatic origin for the tumor. Transmission electron microscopy revealed...

Pierre Hainaut; Marc Castellazzi; Dominique Gonzales; Nathalie Clausse; Jo Hilgers; and Michel Crpin

1990-06-15T23:59:59.000Z

432

Protocol: Mouse Cardiac CINE Protocol, Page 1 of 2 Author: R.Bussell 8/9/2013 Protocol: Mouse Cardiac CINE Protocol  

E-Print Network [OSTI]

monitor. The leads should be twisted along their entire length and never form a loop. Tape leads securely the respiratory bellows between the animal and a hard surface so the respiratory signal is reliable. Set the bladder below the diaphragm. If the bladder is too high you may observe the heart beat in the respiratory

Squire, Larry R.

433

Inactivation of the Human Fragile Histidine Triad Gene at 3p14.2 in Monochromosomal Human/Mouse Microcell Hybrid-derived Severe Combined Immunodeficient Mouse Tumors  

Science Journals Connector (OSTI)

...782 782 R-ATCTGGAATAAGTACCTAAGGCGC UBE1L L13852 PBE F-TGGTGCTGACTGCTGCAAAG 408 1036 R-CTCTTGACTTCAGTGATAGCC LUCA1 U03056 SHGC-11855 GDB:733936 F-CAGACTGGAATAGTGGCATAAGG 210 210 R-GGAATGAATAAGTCCACATAAAACG PTPRG U46116 WI-11100 GDB:1220992...

Irina D. Kholodnyuk; Anna Szeles; Ying Yang; George Klein; Stefan Imreh

2000-12-15T23:59:59.000Z

434

Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models  

Science Journals Connector (OSTI)

...T A/A A/A yes 3 Olfr1253 MK 0.988 3 19910826 het C/C...T A/A A/T yes 3 Osgin2 MK 0.045 4 140271822 het A/A...Solution hybrid selection with ultra-long oligonucleotides for massively...10)77015-4 ) 12 Boles, MK , 2009 Discovery of candidate...

2012-01-01T23:59:59.000Z

435

I hope everyone enjoyed the Thanksgiving break. We are jumping right back in and continue to work on our Optimization Plan. We have some more progress to report, and I want to be sure  

E-Print Network [OSTI]

, and Construction/Project Support. The Environmental, Waste, and Radiation Protection Department will include Environmental Services, Radiation Protection, and Waste Management. Both Department heads will be reporting Program Manager Environment, Waste, and Radiation Protection Department Head · David Shuh ­ Senior

Knowles, David William

436

A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes  

E-Print Network [OSTI]

Lake City, UT 84112; b Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, University of Utah, Salt Lake City, UT 84112 Edited by Neal G. Copeland, Institute of Molecular and Cell. Jonesa,b,1,2 , Virginia Piomboc,1 , Charles Searbyd , Gail Kurrigerb , Baoli Yange , Florian Grabellusf

Capecchi, Mario R.

437

DNA synthetic phase duration of mouse ileal epithelium in acute renal failure  

Science Journals Connector (OSTI)

The effect of progressive acute renal failure on the DNA synthetic phase duration of ileal epithelium was assessed...3-thymidine approximately 18 hours after urinary outflow obstruction in mice. Controls were sub...

Francis T. McDermott; Melinda K. Dalton

438

The effects of triclosan on pluripotency factors and development of mouse embryonic stem cells and zebrafish  

Science Journals Connector (OSTI)

Triclosan (TCS) poses potential risks to reproduction...Sox2 mRNA were not changed, the mRNA levels of Oct4 and Nanog in TCS-treated groups were significantly decreased compared to controls. In addition, the prot...

Xiaojiao Chen; Bo Xu; Xiumei Han; Zhilei Mao; Minjian Chen

2014-05-01T23:59:59.000Z

439

A Comparison of Glucose Utilization by Mouse Liver and by the Transplantable Hepatocarcinoma C954  

Science Journals Connector (OSTI)

...ways recorded here. In addition, we have investi...Duolite A-3 and C-4 ion-exchange resins, and the water eluates...fully borne out by our demonstration of identical recoveries...can be increased by addition of substrates (glucosone...

S. Abraham; I. L. Chaikoff; and P. Cady

1961-08-01T23:59:59.000Z

440

Progressive Genomic Instability in the FVB/Kras[superscript LA2] Mouse Model of Lung Cancer  

E-Print Network [OSTI]

Alterations in DNA copy number contribute to the development and progression of cancers and are common in epithelial tumors. We have used array Comparative Genomic Hybridization (aCGH) to visualize DNA copy number alterations ...

Jacks, Tyler E.

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Patterning Mouse and Human Embryonic Stem Cells Using Micro-contact Printing  

E-Print Network [OSTI]

fabricated in a cleanroom facility, template moulds can be repeatedly used to cast PDMS stamps. Further- more

Zandstra, Peter W.

442

Spontaneous Fusion with, and Transformation of Mouse Stroma by, Malignant Human Breast Cancer Epithelium  

Science Journals Connector (OSTI)

...reprobed and analyzed by laser scanning confocal...Because spontaneous fusion between cells of...mechanism. In sum, cell fusion can be an engine...1113-4. 5 Dvorak HF. Tumors: wounds...alterations in the laser-capture-microdissected...Lazebnik Y. Cell fusion: a hidden enemy...

Britta M. Jacobsen; J. Chuck Harrell; Paul Jedlicka; Virginia F. Borges; Marileila Varella-Garcia; and Kathryn B. Horwitz

2006-08-15T23:59:59.000Z

443

Glucose, Lactate, and Lactic Dehydrogenase Activity in Normal Interstitial Fluid and That of Solid Mouse Tumors  

Science Journals Connector (OSTI)

...distant from the tumor site. Warburg, Wind, and Xegelein (21) obtained similar...Sugar, Lactic Acid and CO2-combining Power of Blood Passing through a Tumor. J...Suppl. 154, 1957. 21. WABB oeRO,O.; WIND, F.; and NEGELEIN,E. Ueber den Stoffwechsel...

E. Ann Burgess and B. Sylvn

1962-06-01T23:59:59.000Z

444

Anti-VEGF Antibodies Mitigate the Development of Radiation Necrosis in Mouse Brain  

Science Journals Connector (OSTI)

...patients (17-19 , 22), though these studies lacked statistical power. MRI monitoring of the onset and progression of radiation necrosis...Neurol Neurosurg Psychiatry 1984;47:1338-41. 5. Siu A , Wind JJ, Iorgulescu JB, Chan TA, Yamada Y Sherman JH.Radiation...

Xiaoyu Jiang; John A. Engelbach; Liya Yuan; Jeremy Cates; Feng Gao; Robert E. Drzymala; Dennis E. Hallahan; Keith M. Rich; Robert E. Schmidt; Joseph J.H. Ackerman; and Joel R. Garbow

2014-05-15T23:59:59.000Z

445

A Structurally Based Investigation of Abdominal Aortic Aneurysms in Mouse Models  

E-Print Network [OSTI]

distensible and experienced non-uniform, but modest dilatation. The constitutive parameters reflect elastin loss and increased collagen loading. We detailed the loss of smooth muscle cell contractility as found in human lesions that form in the thoracic aorta...

Collins, Melissa

2012-02-14T23:59:59.000Z

446

E-Print Network 3.0 - arsenic mouse micronucleus Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Environmental Sciences and Ecology ; Geosciences ; Multidisciplinary Databases and Resources 8 Chronic Exposure to Arsenic Causes Increased Cell Survival, DNA Damage, and...

447

Optical Histology: A Method to Visualize Microvasculature in Thick Tissue Sections of Mouse Brain  

E-Print Network [OSTI]

Austin J. Moy1,2 , Matthew P. Wiersma1,2 , Bernard Choi1,2,3 * 1 Beckman Laser Institute, University: Moy AJ, Wiersma MP, Choi B (2013) Optical Histology: A Method to Visualize Microvasculature in Thick

Rose, Michael R.

448

Cryo-electron tomography of mouse hepatitis virus: Insights into the structure of the coronavirion  

Science Journals Connector (OSTI)

...envelope, giving the virions a solar image to which coronaviruses...of CoVs has been the main obstacle to clarifying details...with a Gatan post-column energy filter and a 2k 2k CCD camera (Gatan). Zero-energy loss imaging was used to...

Montserrat Brcena; Gert T. Oostergetel; Willem Bartelink; Frank G. A. Faas; Arie Verkleij; Peter J. M. Rottier; Abraham J. Koster; Berend Jan Bosch

2009-01-01T23:59:59.000Z

449

Genome Patterns of Selection and Introgression of Haplotypes in Natural Populations of the House Mouse  

E-Print Network [OSTI]

), homologues of human genes involved in adaptations (e.g. alpha-amylase genes) or in genetic diseases (e

Dean, Matthew D.

450

Effect of Alpha-Amylase on the Ehrlich Mouse Ascites Tumour  

Science Journals Connector (OSTI)

... a water-bath equipped with a shaker following the addition of 25 mgm. of a-amylase (three times recrystallized, Worthington) in 0*5 c.c. water for each 34 ... mortality occurred on about the twelfth day. Mice injected with cell preparations incubated with a-amylase for 3 hr. showed a 40 per cent tumour mortality within 40 days. Increasing ...

F. STECKERL; A. OFODILE; R. R. CAMPBELL; G. H. FRIEDELL

1961-09-09T23:59:59.000Z

451

Establishment and Characterization of a Lethal Mouse Model for the Angola Strain of Marburg Virus  

Science Journals Connector (OSTI)

...tissue in the intestines, kidney, lungs, brain, spleen, and liver. This model provides...including liver, spleen, kidney, lung, brain, and intestine, were also harvested...blood, liver, spleen, kidney, lung, brain, and intestine of each animal. BALB...

Xiangguo Qiu; Gary Wong; Jonathan Audet; Todd Cutts; Yulian Niu; Stephanie Booth; Gary P. Kobinger

2014-08-20T23:59:59.000Z

452

In Vivo Role of Phosphorylation of Cryptochrome 2 in the Mouse Circadian Clock  

Science Journals Connector (OSTI)

...u-tokyo.ac.jp . a Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo...Genetics Research Laboratory, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo...

Arisa Hirano; Nobuhiro Kurabayashi; Tomoki Nakagawa; Go Shioi; Takeshi Todo; Tsuyoshi Hirota; Yoshitaka Fukada

2014-10-06T23:59:59.000Z

453

Metabolism and pharmacokinetics of the cyclin-dependent kinase inhibitor R-roscovitine in the mouse  

Science Journals Connector (OSTI)

...hepatic microsomes, plasma, and urine...under an argon atmosphere cooled to 0C was...d6-DMSO, 250 MHz): delta 4...d6-DMSO, 250 MHz): delta 0...at 0C under an atmosphere of argon. When...d6-DMSO, 250 MHz): delta 0...of each). For plasma pharmacokinetic...

Bernard P. Nutley; Florence I. Raynaud; Stuart C. Wilson; Peter M. Fischer; Angela Hayes; Phyllis M. Goddard; Steven J. McClue; Michael Jarman; David P. Lane; and Paul Workman

2005-01-01T23:59:59.000Z

454

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis  

Science Journals Connector (OSTI)

...top of the front paw print. It is evident in...of ALS. Analysis of Plasma, Brain, and Spinal...1 H NMR (CDCl3, 500 MHz) 8.10 (d, 2H...0.13 M) under a N2 atmosphere was cooled in a dry ice...1 H NMR (CDCl3, 400 MHz) 8.23 (d, 2H...

Rachel Tesla; Hamilton Parker Wolf; Pin Xu; Jordan Drawbridge; Sandi Jo Estill; Paula Huntington; LaTisha McDaniel; Whitney Knobbe; Aaron Burket; Stephanie Tran; Ruth Starwalt; Lorraine Morlock; Jacinth Naidoo; Noelle S. Williams; Joseph M. Ready; Steven L. McKnight; Andrew A. Pieper

2012-01-01T23:59:59.000Z

455

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse  

Science Journals Connector (OSTI)

...reflow) occurs in a large number of...tissue in the infarct area composed of tissue...pretreated with gelatin/plasma human-fibronectin...VisualSonics) and a 30-MHz probe as previously...Sigma-Aldrich). The areas of fibrosis and the whole left...a 5% CO2 95% N2 atmosphere in a gas chamber...

Eleonora Mezzaroma; Stefano Toldo; Daniela Farkas; Ignacio M. Seropian; Benjamin W. Van Tassell; Fadi N. Salloum; Harsha R. Kannan; Angela C. Menna; Norbert F. Voelkel; Antonio Abbate

2011-01-01T23:59:59.000Z

456

Metabolism and pharmacokinetics of the cyclin-dependent kinase inhibitor R-roscovitine in the mouse  

Science Journals Connector (OSTI)

...microsomes, plasma, and urine...development from a large set of 2...under an argon atmosphere cooled to...d6-DMSO, 250 MHz): delta...0C under an atmosphere of argon...d6-DMSO, 250 MHz): delta...each). For plasma pharmacokinetic...detected in both plasma or urine...incubations, peak areas of internal...

Bernard P. Nutley; Florence I. Raynaud; Stuart C. Wilson; Peter M. Fischer; Angela Hayes; Phyllis M. Goddard; Steven J. McClue; Michael Jarman; David P. Lane; and Paul Workman

2005-01-01T23:59:59.000Z

457

Epithelial Anion Transporter Pendrin Contributes to Inflammatory Lung Pathology in Mouse Models of Bordetella pertussis Infection  

Science Journals Connector (OSTI)

...Misiak, EC Lavelle, RM McLoughlin, and KH Mills. 2013. Relative contribution of Th1 and...SC , AG Jarnicki, EC Lavelle, and KH Mills. 2006. TLR4 mediates vaccine-induced...Faisy. 2012. Acetazolamide: a second wind for a respiratory stimulant in the intensive...

Karen M. Scanlon; Yael Gau; Jingsong Zhu; Ciaran Skerry; Susan M. Wall; Manoocher Soleimani; Nicholas H. Carbonetti

2014-07-28T23:59:59.000Z

458

Down-regulation of SNAIL suppresses MIN mouse tumorigenesis: Modulation of apoptosis, proliferation, and fractal dimension  

Science Journals Connector (OSTI)

...Foundation grant BES-0238903, General Motors Cancer Research Foundation, and American...AS-PMO optimization has been conducted, future studies will be better able to address...alteration in early precancer. IEEE J Sel Top Quantum Electron 2003;9:243-57. 27 Gurjar...

Hemant K. Roy; Patrick Iversen; John Hart; Yang Liu; Jennifer L. Koetsier; Young Kim; Dhanajay P. Kunte; Madhavi Madugula; Vadim Backman; and Ramesh K. Wali

2004-09-01T23:59:59.000Z

459

Molecular taxonomy of major neuronal classes in the adult mouse forebrain  

E-Print Network [OSTI]

of specific neuronal circuit elements. The mammalian forebrain is a tissue of stunning complexity comprised to which a single canonical circuit comprised of a set of canonical cell types can be recognized across of characteristics including anatomical location, intrinsic firing properties, synaptic physiology, somatodendritic

Cai, Long

460

Hoplopleura janzeni n. sp. (Phthiraptera: Anoplura), a new sucking louse from a Central American swimming mouse  

E-Print Network [OSTI]

HS), 3 dorsal marginal head setae (DMHS), 1 long dorsal principal head seta (DPTS), 1 short dorsal accessory head seta (DAcHS), and 1 dorsal posterior central head seta (DPoCHS) dorsally on each side; 1 DMHS inserted anteriorly and close to dorsal head... 1 lacking setae; sternite 2 with 6 sternal abdominal setae (StAS) with 2 lateral StAS on each side slightly thickened; sternite 3 with 6 StAS with narrow central setae and stout lateral setae (2 on 1 side, 3 on the other); sternites 410 each with 68...

Durden, Lance A.; Timm, Robert M.

2001-12-01T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Use of Course Woody Debris by Cotton Mouse (Peromyscus gossypinus)in a Southeastern Pine Forest  

SciTech Connect (OSTI)

Course woody debris may be an important resource for many small mammals by providing protection and food sources. The author tracked cotton mice movements via radiotelemetry and powder in managed loblolly pine forests. Most day refuges for mice were associated with debris, including rotting stumps (69%), upturned root boles (14%) and under fallen logs (9%). Stumps used were more larger and more highly decomposed. Night time telemetry indicated that mice movements were more closely associated with the logs. Rooting stumps are an important resource for cotton mice.

T.S. McCay

1999-03-22T23:59:59.000Z

462

Genetic programs in human and mouse early embryos revealed by single-cell RNA?sequencing  

Science Journals Connector (OSTI)

... embryos were obtained from the Center for Clinical Reproductive Medicine at the Jiangsu Peoples Hospital, Nanjing, China, with patients written informed consent and institutional approval. Single-cell isolation ... 26?and?35) at the Center for Clinical Reproductive Medicine at the Jiangsu Peoples Hospital, Nanjing, China, with written informed consent and institutional approval. Sperm was obtained from ...

Zhigang Xue; Kevin Huang; Chaochao Cai; Lingbo Cai; Chun-yan Jiang; Yun Feng; Zhenshan Liu; Qiao Zeng; Liming Cheng; Yi E. Sun; Jia-yin Liu; Steve Horvath; Guoping Fan

2013-07-28T23:59:59.000Z

463

Expression of the Wilms' tumor suppressor gene WT1 during mouse embryogenesis  

Science Journals Connector (OSTI)

...ifferential Regulation of the Wilms' Tumor Gene, WTI, during Differentiation of Embryonal Carcinoma...pattern of the Wilms' tumor suppressor gene, WTI, during embryonal development suggests a role for the WTI proteins in the differentiation of specific...

RR Rackley; AM Flenniken; NP Kuriyan; PM Kessler; MH Stoler; BR Williams

1993-12-01T23:59:59.000Z

464

Identification of cis-regulatory elements in mouse Mab21l2 gene by comparative genomics.  

E-Print Network [OSTI]

??The mab-21 gene was first identified in Caenorhabditis elegans as a critical component required for sensory organ identity determination. Mab21 homologs are highly conserved from (more)

Shek, Kim Fung

2010-01-01T23:59:59.000Z

465

Identification of Distal cis-Regulatory Elements at Mouse Mitoferrin Loci Using Zebrafish Transgenesis  

Science Journals Connector (OSTI)

...immunoprecipitation (ChIP) datasets for the major erythroid transcription...triggers erythroid maturation by nuclear translocation of the fusion...FOG-1, induces an exchange of nuclear factors at both CRMs. GATA-2...immunoprecipitation (ChIP) datasets for the major erythroid transcription...

Julio D. Amigo; Ming Yu; Marie-Berengere Troadec; Babette Gwynn; Jeffrey D. Cooney; Amy J. Lambert; Neil C. Chi; Mitchell J. Weiss; Luanne L. Peters; Jerry Kaplan; Alan B. Cantor; Barry H. Paw

2011-01-19T23:59:59.000Z

466

Analysis of pluripotent mouse stem cell proteomes : insights into post- transcriptional regulation of pluripotency and differentiation  

E-Print Network [OSTI]

nuclear data. False discovery rate is reduced by removing single peptide identifications Measured FDR (%) FDR whole dataset

O'Brien, Robert Norman

2010-01-01T23:59:59.000Z

467

NURBS: a database of experimental and predicted nuclear receptor binding sites of mouse  

Science Journals Connector (OSTI)

......experimental and predicted nuclear receptor binding...experiments. All datasets are processed using...derived from different datasets are comparable...edu 1 INTRODUCTION Nuclear receptors (NRs...experimental and predicted nuclear receptor binding...experiments. All datasets are processed using......

Yaping Fang; Hui-Xin Liu; Ning Zhang; Grace L. Guo; Yu-Jui Yvonne Wan; Jianwen Fang

2013-01-15T23:59:59.000Z

468

E-Print Network 3.0 - accelerated mouse sam Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

decision makers can choose among solar, wind, and Summary: to the National Renewable Energy Laboratory (NREL). NREL has developed a tool--the System Advisor Model (SAM... and...

469

Mitochondrial dysfunction in mouse models of Parkinsons disease revealed by transcriptomics and proteomics  

E-Print Network [OSTI]

J Bioenerg Biomembr (2009) 41:487491 DOI 10.1007/s10863-nitrogen species (RNS). J Bioenerg Biomembr (2009) 41:487MPTP and methamphetamine J Bioenerg Biomembr (2009) 41:487

Smith, Desmond J.

2009-01-01T23:59:59.000Z

470

Did "Minority Report" Get it Wrong? Superiority of the Mouse over 3D Input Devices  

E-Print Network [OSTI]

-specialists (e.g., Google Earth, Sketchup) has focused increased attention on the problem of improved interaction

Cooperstock, Jeremy R.

471

From pluripotency to differentiation: laying foundations for the body pattern in the mouse embryo  

Science Journals Connector (OSTI)

...genes in ESCs. They review the TGFbeta-related...previously expected. The body plan of the developing embryo...gastrulation stages. They review how regulatory networks constructed...systems. In the final review, Hadjantonakis and co-workers...

2014-01-01T23:59:59.000Z

472

Initiating head development in mouse embryos: integrating signalling and transcriptional activity  

Science Journals Connector (OSTI)

March 2012 review-article Perspective 1001...generation of an embryonic body plan is the outcome of inductive...the embryo acquires its body plan, which manifests as differences...their proper place in the body plan establishes the blueprint of...

2012-01-01T23:59:59.000Z

473

Biophysical Probes of Iron Metabolism in Yeast Cells, Mitochondria, and Mouse Brains  

E-Print Network [OSTI]

Iron is essential in nearly all organisms. It is a cofactor in many proteins and enzymes. This transition metal can also be toxic because it participates in reactions which produce reactive oxygen species. To avoid these toxic effects while still...

Holmes-Hampton, Gregory

2012-10-19T23:59:59.000Z

474

Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis  

SciTech Connect (OSTI)

Histone deacetylase (HDAC) inhibitors are promising new compounds for the therapy of fibrotic diseases. In this study we compared the effect of two HDAC inhibitors, trichostatin A and valproic acid, in an experimental model of kidney fibrosis. In mice, doxorubicin (adriamycin) can cause nephropathy characterized by chronic proteinuria, glomerular damage and interstitial inflammation and fibrosis, as seen in human focal segmental glomerulosclerosis. Two treatment regimens were applied, treatment was either started prior to the doxorubicin insult or delayed until a significant degree of proteinuria and fibrosis was present. Pre-treatment of trichostatin A significantly hampered glomerulosclerosis and tubulointerstitial fibrosis, as did the pre-treatment with valproic acid. In contrast, the development of proteinuria was only completely inhibited in the pre-treated valproic acid group, and not in the pre-treated trichostatin A animals. In the postponed treatment with valproic acid, a complete resolution of established doxorubicin-induced proteinuria was achieved within three days, whereas trichostatin A could not correct proteinuria in such a treatment regimen. However, both postponed regimens have comparable efficacy in maintaining the kidney fibrosis to the level reached at the start of the treatments. Moreover, not only the process of fibrosis, but also renal inflammation was attenuated by both HDAC inhibitors. Our data confirm a role for HDACs in renal fibrogenesis and point towards a therapeutic potential for HDAC inhibitors. The effect on renal disease progression and manifestation can however be different for individual HDAC inhibitors. - Highlights: Valproic acid is a potent antiproteinuric drug, whereas trichostatin A is not. Trichostatin A and valproic acid reduce kidney fibrosis in doxorubicin nephropathy. Both valproic acid and trichostatin A attenuate renal inflammation.

Van Beneden, Katrien, E-mail: kvbenede@vub.ac.be [Department of Human Anatomy, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium); Geers, Caroline [Department of Pathology, Universitair Ziekenhuis Brussel, Brussels (Belgium); Pauwels, Marina [Department of Human Anatomy, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium); Mannaerts, Inge [Department of Cell Biology, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium); Wissing, Karl M. [Department of Nephrology, Universitair Ziekenhuis Brussel, Brussels (Belgium); Van den Branden, Christiane [Department of Human Anatomy, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium); Grunsven, Leo A. van, E-mail: lvgrunsv@vub.ac.be [Department of Cell Biology, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium)

2013-09-01T23:59:59.000Z

475

E-Print Network 3.0 - apolipoprotein e-deficient mouse Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

17 Research report Summary: , Grauer E, Sehayek E, Michaelson DM. Biochem- ical and cognitive studies of apolipoprotein-E-deficient... . Memory deficits and cholinergic...

476

A novel sex determination system in a close relative of the house mouse  

Science Journals Connector (OSTI)

...Catzeflis, C. Gilbert, B. D. Hayter, J. A. J. Nel and...University of Stellenbosch to J.B.D. and three collaborative grants: CNRS-NRF (nos. 13293 and 15439), PICS...deletion portant sur le bras court d'un X chez Mus (Leggada) triton...

2010-01-01T23:59:59.000Z

477

E-Print Network 3.0 - adult mouse olfactory Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

olfactory bulb has around 3000glomeruli(Meisami, 1979); a similararrange- ... Source: Vogt, Richard G. - Department of Biological Sciences, University of South Carolina...

478

A Role for Endoglin as a Suppressor of Malignancy during Mouse Skin Carcinogenesis  

Science Journals Connector (OSTI)

...Maria Villa-Morales 2 Javier Santos 2 Jose Fernandez-Piqueras...respectively, and Eva G. Santos for skilful technical assistance...Cano A, Perez-Moreno MA, Rodrigo I, et al. The transcription...537-43. 29 Villa-Morales M, Santos J, Fernandez-Piqueras J...

Eduardo Prez-Gmez; Mara Villa-Morales; Javier Santos; Jos Fernndez-Piqueras; Carlos Gamallo; Javier Dotor; Carmelo Bernabu; and Miguel Quintanilla

2007-11-01T23:59:59.000Z

479

Progesterone receptors in the mouse mammary duct: distribution and developmental regulation  

Science Journals Connector (OSTI)

...expressing the 143Ala p53 temperature-sensitive mutant, we demonstrated...Sensitivity and Specificity Temperature Transfection Transplantation...Wild-Type p53 and a p53 Temperature-sensitive Mutant Suppress...Aiqing Lang, Tong Ge, Dantong Sun, Ming Tan, and Dihua Yu2...

GB Silberstein; K Van Horn; G Shyamala; and CW Daniel

1996-07-01T23:59:59.000Z

480

The effects of adult male mouse urine odor on evoked potentials in adult female mice  

E-Print Network [OSTI]

collected with EEG electrodes placed within a cup of physiological saline solution and SCI-LAB turned on Power spectrum of data collected with EEG electrodes placed within a cup of physiological saline solution and SCI-LAB turned off 56 10. Power... spectrum (test 1) of data collected with EEG electrodes tied together and placed within a cup of physiological saline solution 59 power spectrum (test 2) of data collected with EEG electrodes tied together and placed within a cup of physiological...

Brown, Troy Edwin

2012-06-07T23:59:59.000Z

Note: This page contains sample records for the topic "meadow jumping mouse" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Identification of Neuronal Enhancers of the Proopiomelanocortin Gene by Transgenic Mouse Analysis and Phylogenetic Footprinting  

Science Journals Connector (OSTI)

...1428 Buenos Aires, Argentina. Phone: 5411-47832871...Aires, Buenos Aires, Argentina 2 Vollum Institute 3...role in the control of energy homeostasis, and rare...fellowships from CONICET, Argentina. M.J.L. declares...leptin regulation of energy balance but not reproduction...

Flvio S. J. de Souza; Andrea M. Santangelo; Viviana Bumaschny; Mara Elena Avale; James L. Smart; Malcolm J. Low; Marcelo Rubinstein

2005-04-01T23:59:59.000Z

482

Metabolism of an Antineoplastic Methylhydrazine Derivative in a P815 Mouse Neoplasm  

Science Journals Connector (OSTI)

...be introduced into guanine because the hydrogen in the 2-position would be substituted...Adenine and guanine lost 4 and 5 hydrogen atoms, respectively, but each retained...J., and Chase, M. Nucleic Acid Economy in Bacteria Infected with Bacteriophage...

W. Kreis

1970-01-01T23:59:59.000Z

483

TRP channel gene expression in the mouse retina Jared C. Gilliam, Theodore G. Wensel  

E-Print Network [OSTI]

1 in the photoreceptor inner segment layer, for TRPM1 in the inner nuclear layer (INL), for TRPM3 in the INL, and for TRPML1 in the outer plexiform and nuclear layers. Strong immunofluorescence signal in cone outer segments was observed for TRPM7 and TRPP2. TRPC5 immunostaining was largely confined to INL

Wensel, Theodore G.

484

MouseLight: Bimanual Interactions on Di Using a Pen and a  

E-Print Network [OSTI]

Guimbretiere 1 Autodesk Research 210 King St. East, Toronto, ON, M5A 1J7 Canada {firstname.lastname}@autodesk

Keinan, Alon

485

Interleukin 7 (IL-7) selectively promotes mouse and human IL-17producing ?? cells  

Science Journals Connector (OSTI)

...36 Komschlies KL ( 1994 ) Administration of recombinant human IL-7...Geiselhart LA ( 2001 ) IL-7 administration alters the CD4:CD8 ratio...11 ): 1255 1265 . 45 Bonneville M OBrien RL Born WK...Quantitative PCR was performed with Power SYBR Green PCR Master Mix...

Marie-Laure Michel; Dick J. Pang; Syeda F. Y. Haque; Alexandre J. Potocnik; Daniel J. Pennington; Adrian C. Hayday

2012-01-01T23:59:59.000Z

486

Building a better mousetrap: Compressing mouse cursor activity for web analytics  

Science Journals Connector (OSTI)

Abstract Websites can learn what their users do on their pages to provide better content and services to those users. A website can easily find out where a user has been, but in order to find out what content is consumed and how it was consumed at a sub-page level, prior work has proposed client-side tracking to record cursor activity, which is useful for computing the relevance for search results or determining user attention on a page. While recording cursor interactions can be done without disturbing the user, the overhead of recording the cursor trail and transmitting this data over the network can be substantial. In our work, we investigate methods to compress cursor data, taking advantage of the fact that not every cursor coordinate has equal value to the website developer. We evaluate 5 lossless and 5 lossy compression algorithms over two datasets, reporting results about client-side performance, space savings, and how well a lossy algorithm can replicate the original cursor trail. The results show that different compression techniques may be suitable for different goals: LZW offers reasonable lossless compression, but lossy algorithms such as piecewise linear interpolation and distance-thresholding offer better client-side performance and bandwidth reduction.

Luis A. Leiva; Jeff Huang

2015-01-01T23:59:59.000Z

487

Reflectance and Fluorescence Confocal Microscope for Imaging of the Mouse Colon  

E-Print Network [OSTI]

and fluorescence microscope. 20 3.3 Image Formation To form a 2D image using a point-scanning confocal microscope, the beam must be scanned in two dimensions using scanning mirrors. The PMT records a voltage signal from each point which is assigned... and fluorescence microscope. 20 3.3 Image Formation To form a 2D image using a point-scanning confocal microscope, the beam must be scanned in two dimensions using scanning mirrors. The PMT records a voltage signal from each point which is assigned...

Saldua, Meagan Alyssa

2012-02-14T23:59:59.000Z

488

RESPONSE OF THE SWISS ALBINO MOUSE TO THE VIRUS OF NEWCASTLE DISEASE  

Science Journals Connector (OSTI)

...NEWCASTLE DISEASE Reginald L. Reagan A. L. Brueckner Maryland State Board of Agriculture...DISEASE REGINALD L. REAGAN AND A. L. BRUECKNER Maryland State Board of Agriculture...4-6 453 REGINALD L. REAGAN AND A. L. BRUECKNER used for the initial inoculum. Three-hundredths...

Reginald L. Reagan; A. L. Brueckner

1951-04-01T23:59:59.000Z

489

EFFECT OF WEST NILE VIRUS IN THE SWISS ALBINO MOUSE AND THE CAVE BAT  

Science Journals Connector (OSTI)

...M. Schenck M. P. Harmon A. L. Brueckner Live Stock Sanitary Service Laboratory...SCHENCK, M. P. HARMON, AND A. L. BRUECKNER Live Stock Sanitary Service Laboratory...nervous 79 REAGAN, SCHENCK, HARMON, AND BRUECKNER system involvement while the unized mice...

Reginald L. Reagan; D. M. Schenck; M. P. Harmon; A. L. Brueckner

1952-07-01T23:59:59.000Z

490

Picropodophyllin inhibits tumor growth of human nasopharyngeal carcinoma in a mouse model  

SciTech Connect (OSTI)

Highlights: We identified that PPP inhibits IGF-1R/Akt pathway in NPC cells. PPP dose-dependently inhibits NPC cell proliferation in vitro. PPP suppresses tumor growth of NPC in nude mice. PPP have little effect on microtubule assembly. -- Abstract: Insulin-like growth factor-1 receptor (IGF-1R) is a cell membrane receptor with tyrosine kinase activity and plays important roles in cell transformation, tumor growth, tumor invasion, and metastasis. Picropodophyllin (PPP) is a selective IGF-1R inhibitor and shows promising antitumor effects for several human cancers. However, its antitumor effects in nasopharyngeal carcinoma (NPC) remain unclear. The purpose of this study is to investigate the antitumor activity of PPP in NPC using in vitro cell culture and in vivo animal model. We found that PPP dose-dependently decreased the IGF-induced phosphorylation and activity of IGF-1R and consequently reduced the phosphorylation of Akt, one downstream target of IGF-1R. In addition, PPP inhibited NPC cell proliferation in vitro. The half maximal inhibitory concentration (IC50) of PPP for NPC cell line CNE-2 was ?1 ?M at 24 h after treatment and ?0.5 ?M at 48 h after treatment, respectively. Moreover, administration of PPP by intraperitoneal injection significantly suppressed the tumor growth of xenografted NPC in nude mice. Taken together, these results suggest targeting IGF-1R by PPP may represent a new strategy for treatment of NPCs with positive IGF-1R expression.

Yin, Shu-Cheng [Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan 430060 (China) [Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan 430060 (China); Department of Otolaryngology Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071 (China); Guo, Wei [Department of Otolaryngology Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071 (China)] [Department of Otolaryngology Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071 (China); Tao, Ze-Zhang, E-mail: zezhangtao@gmail.com [Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan 430060 (China)] [Department of Otolaryngology Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan 430060 (China)

2013-09-13T23:59:59.000Z

491

E-Print Network 3.0 - ames dwarf mouse Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

object is a brown dwarf. However, the use of this so-called lithium Source: Stancil, Phillip C. - Department of Physics and Astronomy, University of Georgia Collection: Physics...

492

Mouse model implicates GNB3 duplication in a childhood obesity syndrome  

Science Journals Connector (OSTI)

...Mulle Shikha Dharamrup Madhuri R. Hegde Katherine H. Kim Brad Angle Alison Colley Amy E...Hum Genet 87 ( 5 ): 661 666 . 14 Wheeler E ( 2013 ) Genome-wide SNP and CNV analysis identifies common...Hum Genet 13 ( 3 ): 361 369 . 36 Wheeler PG Weaver DD Palmer CG ( 1995 ) Familial...

Ian S. Goldlust; Karen E. Hermetz; Lisa M. Catalano; Richard T. Barfield; Rebecca Cozad; Grace Wynn; Alev Cagla Ozdemir; Karen N. Conneely; Jennifer G. Mulle; Shikha Dharamrup; Madhuri R. Hegde; Katherine H. Kim; Brad Angle; Alison Colley; Amy E. Webb; Erik C. Thorland; Jay W. Ellison; Jill A. Rosenfeld; Blake C. Ballif; Lisa G. Shaffer; Laurie A. Demmer; Unique Rare Chromosome Disorder Support Group; M. Katharine Rudd

2013-01-01T23:59:59.000Z

493

Requirement of Sur2 for Efficient Replication of Mouse Adenovirus Type 1  

Science Journals Connector (OSTI)

...Type 1 Lei Fang 1 Jennitte L. Stevens 2 Arnold J. Berk 2 Katherine R. Spindler 3 Corresponding author. Mailing address: Department...Acad. Sci. USA 99: 12747-12752. 3 Avvakumov, N., R. Wheeler, J. C. DHalluin, and J. S. Mymryk. 2002. Comparative...

Lei Fang; Jennitte L. Stevens; Arnold J. Berk; Katherine R. Spindler

2004-12-01T23:59:59.000Z

494

The relationship among tumor architecture, pharmacokinetics, pharmacodynamics, and efficacy of bortezomib in mouse xenograft models  

Science Journals Connector (OSTI)

...at 37C, 5% CO2 atmosphere, 97% relative humidity...done on a 7T (300 MHz) 210-mm horizontal...spectral width = 100 kHz. Each image took...similar area under the plasma concentration-time...relationship between plasma and tumor pharmacokinetics...tumor perfusion than plasma drug exposures...

Mark J. Williamson; Matthew D. Silva; Jennifer Terkelsen; Robbie Robertson; Li Yu; Cindy Xia; Panos Hatsis; Bret Bannerman; Trisha Babcock; Yueying Cao; and Erik Kupperman

2009-12-01T23:59:59.000Z

495

The relationship among tumor architecture, pharmacokinetics, pharmacodynamics, and efficacy of bortezomib in mouse xenograft models  

Science Journals Connector (OSTI)

...cultured at 37C, 5% CO2 atmosphere, 97% relative humidity...was done on a 7T (300 MHz) 210-mm horizontal...spectral width = 100 kHz. Each image took 5...similar area under the plasma concentration-time...relationship between plasma and tumor pharmacokinetics...tumor perfusion than plasma drug exposures (57...

Mark J. Williamson; Matthew D. Silva; Jennifer Terkelsen; Robbie Robertson; Li Yu; Cindy Xia; Panos Hatsis; Bret Bannerman; Trisha Babcock; Yueying Cao; and Erik Kupperman

2009-12-01T23:59:59.000Z

496

An extensive list of genes that produce alternative transcripts in the mouse  

Science Journals Connector (OSTI)

......symbol chromosome J numbers symbol a 2 J:12911 ASIP J:18750 J:4186 Abl 2 J:40703 ABL1 Acadl 1 J:28013 ACADL Acads 5 J:12776 ACADS Accn1 UN J:44171 ACCN1 Adss2 UN J:16814 NULL Ags X J:30307 GLA J:33774 Akap UN J:39210 AKAP84-PEN Axin 17......

ME Mangan; KS Frazer

1999-02-01T23:59:59.000Z

497

Intravital imaging of amyloid plaques in a transgenic mouse model using optical-resolution  

E-Print Network [OSTI]

; revised November 10, 2009; accepted November 10, 2009; posted November 12, 2009 (Doc. ID 114001 to play a major role in the pathogen- esis of Alzheimer's disease (AD), but the underlying mechanisms

Wang, Lihong

498

An Extract of Phyllanthus amarus Protects Mouse Chromosomes and Intestine from Radiation Induced Damages  

Science Journals Connector (OSTI)

......using Graphpad Instat 3 Software (San Diego, USA...Effect of P.amarus on radiation induced changes in the...Mr. M. Muthuvel, Radiation safety Officer, Amala Cancer...Withers, H. R. (1999) Radiation biology and treatment......

Kuzhuvelil Bhaskaran Nair Harikumar; Ramadasan Kuttan

2007-11-01T23:59:59.000Z

499

Computer simulations reveal complex distribution of haemodynamic forces in a mouse retina model of angiogenesis  

Science Journals Connector (OSTI)

...UK-Israel Initiative BIRAX; EPSRC grants 2020 Science ( http://www.2020science...www.cresta-project.eu/ , grant no. 287703) and MAPPER ( http://www.mapper-project.eu/ , grant no. 261507). C.A.F. is supported...

2014-01-01T23:59:59.000Z

500

Production and Characterization of Mouse Monoclonal Antibodies to Human Bladder Tumor-associated Antigens  

Science Journals Connector (OSTI)

...This report describes the production of four murine McAbs against...harvested with the aid of a rubber policeman and washed three...enough to screen for antibody production (about 3 weeks). Screening...as feeder cells. Antibody Production and Purification. As a source...

Deborah A. Young; George R. Prout, Jr.; and Chi-Wei Lin

1985-09-01T23:59:59.000Z